TY - JOUR T1 - Directed discovery of agents targeting the Met tyrosine kinase domain by virtual screening. AN - 67390238; 19199650 AB - Hepatocyte growth factor (HGF) is an important regulator of normal development and homeostasis, and dysregulated signaling through the HGF receptor, Met, contributes to tumorigenesis, tumor progression, and metastasis in numerous human malignancies. The development of selective small-molecule inhibitors of oncogenic tyrosine kinases (TK) has led to well-tolerated, targeted therapies for a growing number of cancer types. To identify selective Met TK inhibitors, we used a high-throughput virtual screen of the 13.5 million compound ChemNavigator database to find compounds most likely to bind to the Met ATP binding site and to form several critical interactions with binding site residues predicted to stabilize the kinase domain in its inactive conformation. Subsequent biological screening of 70 in silico hit structures using cell-free and intact cell assays identified three active compounds with micromolar IC(50) values. The predicted binding modes and target selectivity of these compounds are discussed and compared to other known Met TK inhibitors. JF - Journal of medicinal chemistry AU - Peach, Megan L AU - Tan, Nelly AU - Choyke, Sarah J AU - Giubellino, Alessio AU - Athauda, Gagani AU - Burke, Terrence R AU - Nicklaus, Marc C AU - Bottaro, Donald P AD - Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. Y1 - 2009/02/26/ PY - 2009 DA - 2009 Feb 26 SP - 943 EP - 951 VL - 52 IS - 4 KW - Antineoplastic Agents KW - 0 KW - Protein Kinase Inhibitors KW - Proto-Oncogene Proteins KW - Receptors, Growth Factor KW - MET protein, human KW - EC 2.7.10.1 KW - Proto-Oncogene Proteins c-met KW - Index Medicus KW - Humans KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Protein Binding KW - Binding Sites KW - Proto-Oncogene Proteins -- antagonists & inhibitors KW - Computer Simulation KW - Protein Kinase Inhibitors -- pharmacology KW - Protein Kinase Inhibitors -- chemistry KW - Receptors, Growth Factor -- antagonists & inhibitors KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Drug Discovery -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67390238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Directed+discovery+of+agents+targeting+the+Met+tyrosine+kinase+domain+by+virtual+screening.&rft.au=Peach%2C+Megan+L%3BTan%2C+Nelly%3BChoyke%2C+Sarah+J%3BGiubellino%2C+Alessio%3BAthauda%2C+Gagani%3BBurke%2C+Terrence+R%3BNicklaus%2C+Marc+C%3BBottaro%2C+Donald+P&rft.aulast=Peach&rft.aufirst=Megan&rft.date=2009-02-26&rft.volume=52&rft.issue=4&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm800791f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-09 N1 - Date created - 2009-06-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Med Res Rev. 2000 Jan;20(1):28-57 [10608920] J Med Chem. 2008 May 22;51(10):2879-82 [18426196] Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26 [11259830] Structure. 2001 Oct;9(10):955-65 [11591350] J Med Chem. 2002 Jun 6;45(12):2615-23 [12036371] Oncogene. 2002 Jul 25;21(32):4885-93 [12118367] Pharmacol Ther. 2002 Feb-Mar;93(2-3):169-78 [12191609] Cancer Metastasis Rev. 2003 Dec;22(4):309-25 [12884908] Cancer Res. 2003 Sep 1;63(17):5462-9 [14500382] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9 [14559966] Cancer Res. 2003 Nov 1;63(21):7345-55 [14612533] Mol Cancer Ther. 2003 Nov;2(11):1085-92 [14617781] Science. 2004 Mar 19;303(5665):1800-5 [15031492] Oncogene. 2004 Jul 8;23(31):5387-93 [15064724] J Mol Biol. 1997 Apr 4;267(3):727-48 [9126849] EMBO J. 1998 Oct 15;17(20):5896-904 [9774334] Curr Mol Med. 2004 Dec;4(8):855-68 [15579033] Nature. 2004 Dec 16;432(7019):862-5 [15602552] Cancer Res. 2005 Feb 15;65(4):1479-88 [15735036] Clin Cancer Res. 2005 Mar 15;11(6):2312-9 [15788682] J Biomol Screen. 2005 Oct;10(7):682-6 [16170046] Drug Discov Today. 2006 Jul;11(13-14):580-94 [16793526] J Med Chem. 2006 Oct 5;49(20):5912-31 [17004707] Nucleic Acids Res. 2007 Jan;35(Database issue):D198-201 [17145705] Cancer Res. 2007 Mar 15;67(6):2712-9 [17363592] Cancer Res. 2007 May 1;67(9):4408-17 [17483355] Breast Cancer Res. 2007;9(2):R23 [17397528] Cancer Res. 2007 Jun 1;67(11):5461-70 [17545628] Cancer Res. 2007 Jul 15;67(14):6899-906 [17638901] J Pathol. 2007 Sep;213(1):82-90 [17607666] Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20932-7 [18093943] J Biol Chem. 2008 Feb 1;283(5):2675-83 [18055465] J Comput Aided Mol Des. 2000 May;14(4):383-401 [10815774] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800791f ER - TY - JOUR T1 - Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. AN - 66966428; 19066394 AB - Organochlorine exposure was linked to non-Hodgkin lymphoma (NHL) risk. To determine whether this relation is modified by immune gene variation, we genotyped 61 polymorphisms in 36 immune genes in 1172 NHL cases and 982 controls from the National Cancer Institute-Surveillance, Epidemiology, and End Results (NCI-SEER) study. We examined 3 exposures with elevated risk in this study: PCB180 (plasma, dust measurements), the toxic equivalency quotient (an integrated functional measure of several organochlorines) in plasma, and alpha-chlordane (dust measurements, self-reported termiticide use). Plasma (100 cases, 100 controls) and dust (682 cases, 513 controls) levels were treated as natural log-transformed continuous variables. Unconditional logistic regression was used to calculate beta coefficients and odds ratios, stratified by genotype. Associations between all 3 exposures and NHL risk were limited to the same genotypes for IFNG (C-1615T) TT and IL4 (5'-UTR, Ex1-168C>T) CC. Associations between PCB180 in plasma and dust and NHL risk were limited to the same genotypes for IL16 (3'-UTR, Ex22+871A>G) AA, IL8 (T-251A) TT, and IL10 (A-1082G) AG/GG. This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL. JF - Blood AU - Colt, Joanne S AU - Rothman, Nathaniel AU - Severson, Richard K AU - Hartge, Patricia AU - Cerhan, James R AU - Chatterjee, Nilanjan AU - Cozen, Wendy AU - Morton, Lindsay M AU - De Roos, Anneclaire J AU - Davis, Scott AU - Chanock, Stephen AU - Wang, Sophia S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7240, USA. coltj@mail.nih.gov Y1 - 2009/02/26/ PY - 2009 DA - 2009 Feb 26 SP - 1899 EP - 1905 VL - 113 IS - 9 KW - Hydrocarbons, Chlorinated KW - 0 KW - Interleukins KW - PCB 180 KW - 35065-29-3 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Abridged Index Medicus KW - Index Medicus KW - Genotype KW - Young Adult KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Polychlorinated Biphenyls -- toxicity KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Interleukins -- genetics KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Hydrocarbons, Chlorinated -- toxicity KW - Lymphoma, Non-Hodgkin -- etiology KW - Immunity, Innate -- genetics KW - Lymphoma, Non-Hodgkin -- immunology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66966428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Organochlorine+exposure%2C+immune+gene+variation%2C+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Colt%2C+Joanne+S%3BRothman%2C+Nathaniel%3BSeverson%2C+Richard+K%3BHartge%2C+Patricia%3BCerhan%2C+James+R%3BChatterjee%2C+Nilanjan%3BCozen%2C+Wendy%3BMorton%2C+Lindsay+M%3BDe+Roos%2C+Anneclaire+J%3BDavis%2C+Scott%3BChanock%2C+Stephen%3BWang%2C+Sophia+S&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2009-02-26&rft.volume=113&rft.issue=9&rft.spage=1899&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-04-153858 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-10 N1 - Date created - 2009-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2007 Jun 1;67(11):5545-52 [17545638] Lancet. 1997 Jul 26;350(9073):240-4 [9242800] Cancer Causes Control. 2007 Oct;18(8):821-31 [17588155] Blood. 2007 Dec 15;110(13):4455-63 [17827388] Am J Epidemiol. 1997 Jun 15;145(12):1061-75 [9199536] Environ Health Perspect. 2000 Dec;108(12):1203-7 [11133402] Leuk Lymphoma. 2001 Aug;42(4):619-29 [11697490] Environ Health Perspect. 2002 Jun;110(6):595-600 [12055051] Leuk Lymphoma. 2002 Jun;43(6):1203-10 [12152987] Food Chem Toxicol. 2003 Jan;41(1):107-18 [12453735] Am J Hum Genet. 2003 Jun;72(6):1505-14 [12748907] Clin Immunol. 2003 Nov;109(2):119-29 [14597210] IARC Monogr Eval Carcinog Risks Hum. 1997;69:1-631 [9379504] Environ Health Perspect. 1998 Dec;106(12):775-92 [9831538] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] Epidemiology. 2005 Jul;16(4):516-25 [15951670] Cancer Res. 2005 Dec 1;65(23):11214-26 [16322272] Lancet Oncol. 2006 Jan;7(1):27-38 [16389181] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):251-7 [16492912] Blood. 2006 May 15;107(10):4101-8 [16449530] Cancer Res. 2006 Oct 1;66(19):9771-80 [17018637] Mol Hum Reprod. 2007 Feb;13(2):135-40 [17178764] Chemosphere. 2007 Apr;67(9):S393-8 [17222440] Carcinogenesis. 2007 Mar;28(3):704-12 [17056605] Cancer Res. 2007 May 15;67(10):5042-54 [17510437] J Expo Anal Environ Epidemiol. 2004 Jan;14(1):74-83 [14726946] Environ Health Perspect. 2004 Jun;112(8):854-61 [15175172] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] Am J Ind Med. 1990;18(6):665-73 [2264565] Arch Environ Health. 1992 Jul-Aug;47(4):295-301 [1497384] Epidemiology. 1993 Sep;4(5):398-406 [8399687] Blood. 1994 Sep 1;84(5):1361-92 [8068936] Exp Clin Immunogenet. 1994;11(2-3):149-62 [7826664] Environ Health Perspect. 1995 Mar;103 Suppl 2:135-42 [7614935] Pediatr Res. 1995 Sep;38(3):404-10 [7494667] Am J Ophthalmol. 1995 Nov;120(5):671-3 [7485372] Eur J Immunogenet. 1997 Feb;24(1):1-8 [9043871] Haematologica. 2007 Jul;92(7):960-9 [17606447] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-04-153858 ER - TY - CPAPER T1 - Chromatin Boundaries T2 - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AN - 41901150; 5113938 JF - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AU - Felsenfeld, Gary Y1 - 2009/02/25/ PY - 2009 DA - 2009 Feb 25 KW - Chromatin KW - Boundaries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41901150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.atitle=Chromatin+Boundaries&rft.au=Felsenfeld%2C+Gary&rft.aulast=Felsenfeld&rft.aufirst=Gary&rft.date=2009-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 00 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - p300 Facilitates the Formation of Pre-Positioned RNA Polymerase T2 - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AN - 41901112; 5113952 JF - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AU - Byun, Jung Y1 - 2009/02/25/ PY - 2009 DA - 2009 Feb 25 KW - DNA-directed RNA polymerase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41901112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.atitle=p300+Facilitates+the+Formation+of+Pre-Positioned+RNA+Polymerase&rft.au=Byun%2C+Jung&rft.aulast=Byun&rft.aufirst=Jung&rft.date=2009-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 00 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-Wide Interaction of Nuclear Receptors with Chromatin T2 - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AN - 41900556; 5113942 JF - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AU - Hager, Gordon Y1 - 2009/02/25/ PY - 2009 DA - 2009 Feb 25 KW - Nuclear receptors KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.atitle=Genome-Wide+Interaction+of+Nuclear+Receptors+with+Chromatin&rft.au=Hager%2C+Gordon&rft.aulast=Hager&rft.aufirst=Gordon&rft.date=2009-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 00 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Change of Histone Modifications during Differentiation T2 - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AN - 41899913; 5113951 JF - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AU - Zhao, Keji Y1 - 2009/02/25/ PY - 2009 DA - 2009 Feb 25 KW - Histones KW - Differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.atitle=Dynamic+Change+of+Histone+Modifications+during+Differentiation&rft.au=Zhao%2C+Keji&rft.aulast=Zhao&rft.aufirst=Keji&rft.date=2009-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 00 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histone Deacetylation and Dicer-Dependent Small RNAs Control Chromatin Condensation within Vertebrate Constitutive Heterochromatin T2 - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AN - 41888720; 5113947 JF - 2009 Keystone Symposia on Chromatin Dynamics and Higher Order Organization (C4) AU - Giles, Keith Y1 - 2009/02/25/ PY - 2009 DA - 2009 Feb 25 KW - Histones KW - Heterochromatin KW - Condensation KW - Chromatin KW - Deacetylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.atitle=Histone+Deacetylation+and+Dicer-Dependent+Small+RNAs+Control+Chromatin+Condensation+within+Vertebrate+Constitutive+Heterochromatin&rft.au=Giles%2C+Keith&rft.aulast=Giles&rft.aufirst=Keith&rft.date=2009-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Chromatin+Dynamics+and+Higher+Order+Organization+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 00 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - B Lymphocytes Exit Lymph Nodes through Cortical Lymphatic Sinusoids Near to Lymph Node Follicles by a Mechanism Independent of S1P-Mediated Chemotaxis T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41955100; 5114405 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Park, Chung Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Lymph nodes KW - Lymphocytes KW - Lymphocytes B KW - Cortex KW - Chemotaxis KW - Follicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41955100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=B+Lymphocytes+Exit+Lymph+Nodes+through+Cortical+Lymphatic+Sinusoids+Near+to+Lymph+Node+Follicles+by+a+Mechanism+Independent+of+S1P-Mediated+Chemotaxis&rft.au=Park%2C+Chung&rft.aulast=Park&rft.aufirst=Chung&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - AID tumorigenic activity T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41930368; 5114414 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Casellas, Rafael Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Activation-induced cytidine deaminase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41930368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=AID+tumorigenic+activity&rft.au=Casellas%2C+Rafael&rft.aulast=Casellas&rft.aufirst=Rafael&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A "conformation-induced oligomerization" Model for the Initiation of B cell receptor signaling T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41930057; 5114347 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Pierce, Susan Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Signal transduction KW - Lymphocytes B KW - Oligomerization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41930057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=A+%22conformation-induced+oligomerization%22+Model+for+the+Initiation+of+B+cell+receptor+signaling&rft.au=Pierce%2C+Susan&rft.aulast=Pierce&rft.aufirst=Susan&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction: From Cells to Humans T2 - 2009 Keystone Symposia on Complications of Diabetes and Obesity (J7) AN - 41913918; 5113423 JF - 2009 Keystone Symposia on Complications of Diabetes and Obesity (J7) AU - Quon, Michael Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Insulin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Complications+of+Diabetes+and+Obesity+%28J7%29&rft.atitle=Reciprocal+Relationships+Between+Insulin+Resistance+and+Endothelial+Dysfunction%3A+From+Cells+to+Humans&rft.au=Quon%2C+Michael&rft.aulast=Quon&rft.aufirst=Michael&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Complications+of+Diabetes+and+Obesity+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toll-Like Receptor 4 Signaling Augments B lymphocyte Migratory and Proliferative Programs, and Overcomes the Restriction that Limits Access to the Dark Zones of Germinal Centers T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41908710; 5114337 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Kehrl, John Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Lymphocytes KW - Signal transduction KW - Lymphocytes B KW - TLR4 protein KW - Germinal centers KW - Cell migration KW - Toll-like receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41908710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=Toll-Like+Receptor+4+Signaling+Augments+B+lymphocyte+Migratory+and+Proliferative+Programs%2C+and+Overcomes+the+Restriction+that+Limits+Access+to+the+Dark+Zones+of+Germinal+Centers&rft.au=Kehrl%2C+John&rft.aulast=Kehrl&rft.aufirst=John&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rearrangement Associated Epigenetic Changes Distinguish DJH Junctions for VH Recombination T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41906295; 5114376 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Subrahmanyam, Ramesh Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Recombination KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41906295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=Rearrangement+Associated+Epigenetic+Changes+Distinguish+DJH+Junctions+for+VH+Recombination&rft.au=Subrahmanyam%2C+Ramesh&rft.aulast=Subrahmanyam&rft.aufirst=Ramesh&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Consequences of Single Round Antigen Receptor Signaling in Naive B Cells T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41904903; 5114371 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Damdinsuren, Bazarragchaa Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Signal transduction KW - Lymphocytes B KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=Functional+Consequences+of+Single+Round+Antigen+Receptor+Signaling+in+Naive+B+Cells&rft.au=Damdinsuren%2C+Bazarragchaa&rft.aulast=Damdinsuren&rft.aufirst=Bazarragchaa&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Systems Approach Using Genome-Wide Small RNA Profiling for Studying B Cell Development, Activation, and Differentiation T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41902568; 5114373 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Kuchen, Stefan Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Lymphocytes B KW - Differentiation KW - RNA KW - Cell activation KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=A+Systems+Approach+Using+Genome-Wide+Small+RNA+Profiling+for+Studying+B+Cell+Development%2C+Activation%2C+and+Differentiation&rft.au=Kuchen%2C+Stefan&rft.aulast=Kuchen&rft.aufirst=Stefan&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualizing the Cell-Cell Interactions Underlying Humoral Immune Responses T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41902389; 5114382 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Germain, Ronald Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Cell interactions KW - Immune response (humoral) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=Visualizing+the+Cell-Cell+Interactions+Underlying+Humoral+Immune+Responses&rft.au=Germain%2C+Ronald&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interferon Regulatory Factor 6 (IRF6) Influences Late B Cell Differentiation T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41902385; 5114331 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Shin, Dong-Mi Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Cell differentiation KW - Lymphocytes B KW - Interferon regulatory factor KW - Differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=Interferon+Regulatory+Factor+6+%28IRF6%29+Influences+Late+B+Cell+Differentiation&rft.au=Shin%2C+Dong-Mi&rft.aulast=Shin&rft.aufirst=Dong-Mi&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Cis-Regulatory Elements Targeting AID-Mediated Sequence Diversification to the Chicken Immunoglobulin Light Chain Gene T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41899185; 5114288 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Fugmann, Sebastian Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Light chains KW - Immunoglobulins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=Identification+of+Cis-Regulatory+Elements+Targeting+AID-Mediated+Sequence+Diversification+to+the+Chicken+Immunoglobulin+Light+Chain+Gene&rft.au=Fugmann%2C+Sebastian&rft.aulast=Fugmann&rft.aufirst=Sebastian&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Update on NIAID Funding Opportunities T2 - 2009 Keystone Symposia on B Cells in Context (C3) AN - 41891131; 5114390 JF - 2009 Keystone Symposia on B Cells in Context (C3) AU - Bansal, Geetha Y1 - 2009/02/24/ PY - 2009 DA - 2009 Feb 24 KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41891131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.atitle=Update+on+NIAID+Funding+Opportunities&rft.au=Bansal%2C+Geetha&rft.aulast=Bansal&rft.aufirst=Geetha&rft.date=2009-02-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+B+Cells+in+Context+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profiling Environmental Chemicals in the Cellular Stress Pathway using Quantitative High-Throughput Screening T2 - Sixth Conference on Screening, Fifth Conference on MedChem and Second Conference on ADMET Europe AN - 41704992; 5024617 JF - Sixth Conference on Screening, Fifth Conference on MedChem and Second Conference on ADMET Europe AU - Shukla, Sunita Y1 - 2009/02/23/ PY - 2009 DA - 2009 Feb 23 KW - Stress KW - Chemicals KW - High-throughput screening KW - Screening KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41704992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Conference+on+Screening%2C+Fifth+Conference+on+MedChem+and+Second+Conference+on+ADMET+Europe&rft.atitle=Profiling+Environmental+Chemicals+in+the+Cellular+Stress+Pathway+using+Quantitative+High-Throughput+Screening&rft.au=Shukla%2C+Sunita&rft.aulast=Shukla&rft.aufirst=Sunita&rft.date=2009-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Conference+on+Screening%2C+Fifth+Conference+on+MedChem+and+Second+Conference+on+ADMET+Europe&rft.issn=&rft_id=info:doi/ L2 - http://www.selectbiosciences.com/conferences/SE_MED_AD09/Agenda.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A central role for the cilium in congenital heart disease T2 - 2009 Gordon Research Conference on Cilia, Mucus and Mucociliary Interactions AN - 41944871; 5116190 JF - 2009 Gordon Research Conference on Cilia, Mucus and Mucociliary Interactions AU - Lo, Cecilia Y1 - 2009/02/22/ PY - 2009 DA - 2009 Feb 22 KW - Heart diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41944871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Cilia%2C+Mucus+and+Mucociliary+Interactions&rft.atitle=A+central+role+for+the+cilium+in+congenital+heart+disease&rft.au=Lo%2C+Cecilia&rft.aulast=Lo&rft.aufirst=Cecilia&rft.date=2009-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Cilia%2C+Mucus+and+Mucociliary+Interactions&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=cilia LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biomarker Qualification and Validation as a Surrogate in Lymphoma and Lung Cancer - Current Progress and Future Challenges for Use in Drug Development T2 - 2009 Keystone Symposia on Imaging and Drug Development (C1) AN - 41937187; 5113783 JF - 2009 Keystone Symposia on Imaging and Drug Development (C1) AU - Kelloff, Gary Y1 - 2009/02/22/ PY - 2009 DA - 2009 Feb 22 KW - Lymphoma KW - Bioindicators KW - Lung cancer KW - Drug development KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41937187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Imaging+and+Drug+Development+%28C1%29&rft.atitle=Biomarker+Qualification+and+Validation+as+a+Surrogate+in+Lymphoma+and+Lung+Cancer+-+Current+Progress+and+Future+Challenges+for+Use+in+Drug+Development&rft.au=Kelloff%2C+Gary&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2009-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Imaging+and+Drug+Development+%28C1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PET Radiotracers: Facing the Biological Reality - BBB and Metabolic Enzymes T2 - 2009 Keystone Symposia on Imaging and Drug Development (C1) AN - 41927970; 5113770 JF - 2009 Keystone Symposia on Imaging and Drug Development (C1) AU - Pike, Victor Y1 - 2009/02/22/ PY - 2009 DA - 2009 Feb 22 KW - Enzymes KW - Blood-brain barrier KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41927970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Imaging+and+Drug+Development+%28C1%29&rft.atitle=PET+Radiotracers%3A+Facing+the+Biological+Reality+-+BBB+and+Metabolic+Enzymes&rft.au=Pike%2C+Victor&rft.aulast=Pike&rft.aufirst=Victor&rft.date=2009-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Imaging+and+Drug+Development+%28C1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Molecular Imaging to Identify Phenotypic Differences between Mood Disorder Subtypes T2 - 2009 Keystone Symposia on Imaging and Drug Development (C1) AN - 41897025; 5113785 JF - 2009 Keystone Symposia on Imaging and Drug Development (C1) AU - Drevets, Wayne Y1 - 2009/02/22/ PY - 2009 DA - 2009 Feb 22 KW - Imaging techniques KW - Mood KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Imaging+and+Drug+Development+%28C1%29&rft.atitle=Using+Molecular+Imaging+to+Identify+Phenotypic+Differences+between+Mood+Disorder+Subtypes&rft.au=Drevets%2C+Wayne&rft.aulast=Drevets&rft.aufirst=Wayne&rft.date=2009-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Imaging+and+Drug+Development+%28C1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Regulatory RNAs in Bacteria AN - 20360084; 9038628 AB - Bacteria possess numerous and diverse means of gene regulation using RNA molecules, including mRNA leaders that affect expression in cis, small RNAs that bind to proteins or base pair with target RNAs, and CRISPR RNAs that inhibit the uptake of foreign DNA. Although examples of RNA regulators have been known for decades in bacteria, we are only now coming to a full appreciation of their importance and prevalence. Here, we review the known mechanisms and roles of regulatory RNAs, highlight emerging themes, and discuss remaining questions. JF - Cell AU - Waters, L S AU - Storz, G AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA, storz@helix.nih.gov Y1 - 2009/02/20/ PY - 2009 DA - 2009 Feb 20 SP - 615 EP - 628 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 136 IS - 4 SN - 0092-8674, 0092-8674 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids KW - Reviews KW - Gene regulation KW - DNA KW - Base pairs KW - mRNA KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20360084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Regulatory+RNAs+in+Bacteria&rft.au=Waters%2C+L+S%3BStorz%2C+G&rft.aulast=Waters&rft.aufirst=L&rft.date=2009-02-20&rft.volume=136&rft.issue=4&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/10.1016%2Fj.cell.2009.01.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene regulation; Reviews; DNA; mRNA; Base pairs DO - http://dx.doi.org/10.1016/j.cell.2009.01.043 ER - TY - JOUR T1 - Exposure to cerebrospinal fluid of sporadic amyotrophic lateral sclerosis patients alters Nav1.6 and Kv1.6 channel expression in rat spinal motor neurons. AN - 66882294; 19109933 AB - Cerebro Spinal Fluid (CSF) from patients with ALS has been documented to have a toxic effect on motor neurons both in vivo and in vitro. Here we show that the CSF from Amyotrophic Lateral Sclerosis (ALS) patients (ALS-CSF) has the potential to perturb ion channel expression, specifically the Na(v)1.6, and K(v)1.6 channels in newborn rat spinal motor neurons both in vivo and in vitro. ALS-CSF and CSF from nonALS patients (nonALS-CSF) were intrathecally injected into 3-day-old rat pups at the rate of 1 microl/2.5 min using a microinjector. In addition, embryonic rat spinal cord cultures were also exposed to 10% ALS or nonALS-CSF on the 9th day in vitro (9DIV) in serum free DMEM medium. After 48 h of CSF exposure, the cultures and the spinal cord sections were processed for immunostaining of the above mentioned ion channels. We observed a decrease in the expression of Na(v)1.6 and K(v)1.6 channels in motor neurons in ALS-CSF treated group, and the presence of trophic factors like Brain Derived Neurotrophic Factor (BDNF) and Ciliary Neurotrophic Factor CNTF partially reversed the effects produced by ALS-CSF. Altered expression of these voltage-gated channels may interfere with the electrical activity of motor neurons, and thereby lead to the degeneration of neurons. JF - Brain research AU - Gunasekaran, R AU - Narayani, R Sankara AU - Vijayalakshmi, K AU - Alladi, Phalguni Anand AU - Shobha, K AU - Nalini, A AU - Sathyaprabha, T N AU - Raju, T R AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Post Box no: 2900, Hosur Road, Bangalore-560 029, India. Y1 - 2009/02/19/ PY - 2009 DA - 2009 Feb 19 SP - 170 EP - 179 VL - 1255 KW - Biological Factors KW - 0 KW - Kv1.6 Potassium Channel KW - Sodium Channels KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Spinal Cord -- metabolism KW - Cells, Cultured KW - Injections, Spinal KW - Humans KW - Spinal Cord -- drug effects KW - Rats, Wistar KW - Gene Expression Regulation KW - Microinjections KW - Spinal Cord -- cytology KW - Motor Neurons -- metabolism KW - Cerebrospinal Fluid KW - Biological Factors -- cerebrospinal fluid KW - Amyotrophic Lateral Sclerosis -- metabolism KW - Biological Factors -- toxicity KW - Sodium Channels -- metabolism KW - Motor Neurons -- drug effects KW - Kv1.6 Potassium Channel -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66882294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Exposure+to+cerebrospinal+fluid+of+sporadic+amyotrophic+lateral+sclerosis+patients+alters+Nav1.6+and+Kv1.6+channel+expression+in+rat+spinal+motor+neurons.&rft.au=Gunasekaran%2C+R%3BNarayani%2C+R+Sankara%3BVijayalakshmi%2C+K%3BAlladi%2C+Phalguni+Anand%3BShobha%2C+K%3BNalini%2C+A%3BSathyaprabha%2C+T+N%3BRaju%2C+T+R&rft.aulast=Gunasekaran&rft.aufirst=R&rft.date=2009-02-19&rft.volume=1255&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2008.11.099 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-18 N1 - Date created - 2009-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2008.11.099 ER - TY - JOUR T1 - Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. AN - 66943149; 19196967 AB - Many studies have implicated the cAMP Response Element Binding (CREB) protein signaling pathway in long-term memory. To identify small molecule enhancers of CREB activation of gene expression, we screened approximately 73,000 compounds, each at 7-15 concentrations in a quantitative high-throughput screening (qHTS) format, for activity in cells by assaying CREB mediated beta-lactamase reporter gene expression. We identified 1,800 compounds that potentiated CREB mediated gene expression, with potencies as low as 16 nM, comprising 96 structural series. Mechanisms of action were systematically determined, and compounds that affect phosphodiesterase 4, protein kinase A, and cAMP production were identified, as well as compounds that affect CREB signaling via apparently unidentified mechanisms. qHTS followed by interrogation of pathway targets is an efficient paradigm for lead generation for chemical genomics and drug development. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Xia, Menghang AU - Huang, Ruili AU - Guo, Vicky AU - Southall, Noel AU - Cho, Ming-Hsuang AU - Inglese, James AU - Austin, Christopher P AU - Nirenberg, Marshall AD - NIH Chemical Genomics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/02/17/ PY - 2009 DA - 2009 Feb 17 SP - 2412 EP - 2417 VL - 106 IS - 7 KW - Cyclic AMP Response Element-Binding Protein KW - 0 KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Animals KW - Cricetulus KW - Humans KW - Gene Expression KW - Gene Expression Profiling KW - Phosphorylation KW - CHO Cells KW - Inhibitory Concentration 50 KW - beta-Lactamases -- metabolism KW - Cell Line KW - Signal Transduction KW - Cricetinae KW - Memory KW - Cyclic AMP Response Element-Binding Protein -- metabolism KW - Gene Expression Regulation, Enzymologic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66943149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Identification+of+compounds+that+potentiate+CREB+signaling+as+possible+enhancers+of+long-term+memory.&rft.au=Xia%2C+Menghang%3BHuang%2C+Ruili%3BGuo%2C+Vicky%3BSouthall%2C+Noel%3BCho%2C+Ming-Hsuang%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BNirenberg%2C+Marshall&rft.aulast=Xia&rft.aufirst=Menghang&rft.date=2009-02-17&rft.volume=106&rft.issue=7&rft.spage=2412&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0813020106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-27 N1 - Date created - 2009-02-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Biochem. 1999;68:821-61 [10872467] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Biochem Pharmacol. 2000 Nov 1;60(9):1333-41 [11008127] J Biol Chem. 2001 Jan 19;276(3):1735-41 [11013247] J Neurosci. 2001 Aug 15;21(16):6000-7 [11487623] Biol Pharm Bull. 2002 Nov;25(11):1422-6 [12419952] J Biol Chem. 2003 Feb 21;278(8):5493-6 [12493749] Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10518-22 [12930888] Neuron. 2004 Jun 24;42(6):947-59 [15207239] J Neurosci. 2004 Oct 6;24(40):8823-8 [15470148] Neuroscience. 2004;129(1):101-7 [15489033] Biochem Pharmacol. 1972 Sep 15;21(18):2443-50 [4345859] Nature. 1988 Aug 11;334(6182):494-8 [2900470] Cell. 1989 Nov 17;59(4):675-80 [2573431] Cell. 1992 Jul 10;70(1):105-13 [1352481] Neuron. 1993 Mar;10(3):427-35 [8384857] Mol Cell Biol. 1993 May;13(5):2822-34 [8386317] Nature. 1993 Oct 28;365(6449):855-9 [8413673] Biochem Pharmacol. 1993 Oct 19;46(8):1435-43 [8240393] Drug Discov Today. 2007 Feb;12(3-4):156-60 [17275736] Circ Res. 2007 Feb 16;100(3):309-27 [17307970] Nat Chem Biol. 2007 Aug;3(8):466-79 [17637779] Br J Pharmacol. 2007 Sep;152(1):53-61 [17603542] Bioorg Med Chem Lett. 2008 Feb 15;18(4):1297-303 [18243697] Mol Cell Biol. 1994 Sep;14(9):6107-16 [8065343] Cell. 1994 Oct 7;79(1):49-58 [7923376] Cell. 1994 Oct 7;79(1):59-68 [7923378] Nature. 1995 Jul 27;376(6538):348-51 [7630403] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8991-6 [9671792] Cell Signal. 1998 Jun;10(6):427-40 [9720765] Biochem Pharmacol. 1999 Jun 15;57(12):1375-82 [10353258] Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16058-63 [15522971] J Clin Invest. 2004 Dec;114(11):1624-34 [15578094] Trends Neurosci. 2005 Aug;28(8):436-45 [15982754] Pharmacol Ther. 2006 Mar;109(3):366-98 [16102838] Neuroreport. 2000 Aug 3;11(11):2577-80 [10943725] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0813020106 ER - TY - JOUR T1 - Adipokine genes and prostate cancer risk. AN - 66746238; 19035456 AB - Adiposity and adipocyte-derived cytokines have been implicated in prostate carcinogenesis. However, the relationship of adipokine gene variants with prostate cancer risk has not been thoroughly investigated. We therefore examined common variants of the IL6, LEP, LEPR, TNF and ADIPOQ genes in relation to prostate cancer in a case-control study nested within a large cohort of Finnish men. The study sample consisted of 1,053 cases of prostate cancer, diagnosed over an average 11 years of follow up, and 1,053 controls matched to the cases on age, intervention group and date of baseline blood draw. Logistic regression was used to model the relative odds of prostate cancer. We also examined genotypes in relation to serum insulin, IGF-1 and IGF-1:IGFBP-3 among 196 controls. Variant alleles at three loci (-14858A>G, -13973A>C, -13736C>A) in a potential regulatory region of the LEP gene conferred a statistically significant 20% reduced risk of prostate cancer. For example, at the -14858A>G locus, heterozygotes and homozygotes for the A allele had an odds ratio (OR) of prostate cancer of 0.76 [95% confidence interval (CI) 0.62, 0.93] and 0.79 (95% CI 0.60, 1.04), respectively. At 13288G>A, relative to the GG genotype, the AA genotype was associated with a suggestive increased risk of prostate cancer (OR = 1.29; 95% CI 0.99,1.67; p(trend) = 0.05). Polymorphisms in the IL6, LEPR, TNF and ADIPOQ genes were not associated with prostate cancer. Allelic variants in the LEP gene are related to prostate cancer risk, supporting a role for leptin in prostate carcinogenesis. JF - International journal of cancer AU - Moore, Steven C AU - Leitzmann, Michael F AU - Albanes, Demetrius AU - Weinstein, Stephanie J AU - Snyder, Kirk AU - Virtamo, Jarmo AU - Ahn, Jiyoung AU - Mayne, Susan T AU - Yu, Herbert AU - Peters, Ulrike AU - Gunter, Marc J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. moorest@mail.nih.gov Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 869 EP - 876 VL - 124 IS - 4 KW - Adipokines KW - 0 KW - Adiponectin KW - Cytokines KW - Insulin KW - Interleukin-6 KW - Leptin KW - Receptors, Leptin KW - Tumor Necrosis Factor-alpha KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Index Medicus KW - Risk KW - Finland KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Insulin-Like Growth Factor I -- metabolism KW - Insulin -- metabolism KW - Aged KW - Middle Aged KW - Cytokines -- metabolism KW - Linkage Disequilibrium KW - Male KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- pathology KW - Prostatic Neoplasms -- epidemiology KW - Adiponectin -- metabolism KW - Interleukin-6 -- metabolism KW - Receptors, Leptin -- metabolism KW - Adipokines -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Leptin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66746238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Adipokine+genes+and+prostate+cancer+risk.&rft.au=Moore%2C+Steven+C%3BLeitzmann%2C+Michael+F%3BAlbanes%2C+Demetrius%3BWeinstein%2C+Stephanie+J%3BSnyder%2C+Kirk%3BVirtamo%2C+Jarmo%3BAhn%2C+Jiyoung%3BMayne%2C+Susan+T%3BYu%2C+Herbert%3BPeters%2C+Ulrike%3BGunter%2C+Marc+J&rft.aulast=Moore&rft.aufirst=Steven&rft.date=2009-02-15&rft.volume=124&rft.issue=4&rft.spage=869&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.24043 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-14 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1998 Mar 26;392(6674):398-401 [9537324] Ann Hum Genet. 1999 May;63(Pt 3):227-34 [10738535] Science. 1998 Sep 11;281(5383):1683-6 [9733517] Comp Biochem Physiol A Mol Integr Physiol. 2000 Mar;125(3):285-98 [10794958] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] Prostate. 2001 Jan 1;46(1):62-7 [11170133] J Clin Endocrinol Metab. 2001 Mar;86(3):1341-5 [11238530] Ann Hum Genet. 2000 Sep;64(Pt 5):391-4 [11281277] J Natl Cancer Inst. 2001 May 16;93(10):783-9 [11353789] Atherosclerosis. 2001 Aug;157(2):495-503 [11472752] Cancer Res. 2002 Jun 15;62(12):3369-72 [12067976] Science. 2002 Jun 21;296(5576):2225-9 [12029063] Horm Metab Res. 2002 Jul;34(7):355-9 [12189581] Acta Oncol. 2002;41(4):381-8 [12234031] Int J Cancer. 2003 Jan 10;103(2):241-5 [12455039] Annu Rev Med. 2003;54:131-52 [12525670] Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):474-5 [12750247] BJU Int. 2003 Jul;92(1):109-12 [12823393] Cancer Res. 2003 Jul 15;63(14):3991-4 [12873996] Eur J Cancer Prev. 2003 Aug;12(4):309-15 [12883384] Endocrinology. 2003 Sep;144(9):3765-73 [12933646] Med Sci Sports Exerc. 2003 Oct;35(10):1662-9 [14523302] Prostate. 2004 May 15;59(3):268-74 [15042602] Urol Int. 2004;73(1):41-6 [15263792] Am J Hum Genet. 2004 Aug;75(2):220-30 [15197684] Eur J Cancer Prev. 2004 Oct;13(5):359-68 [15452447] Eur J Cancer Prev. 1992 Apr;1(3):239-45 [1467769] Nature. 1994 Dec 1;372(6505):425-32 [7984236] J Natl Cancer Inst. 1996 Nov 6;88(21):1560-70 [8901854] J Clin Endocrinol Metab. 1997 Apr;82(4):1066-70 [9100574] FASEB J. 1998 Jan;12(1):57-65 [9438411] Diabetes. 1998 Mar;47(3):487-9 [9519759] Circ Res. 1998 Nov 16;83(10):1059-66 [9815153] J Clin Endocrinol Metab. 1998 Dec;83(12):4382-5 [9851781] J Androl. 1999 Jul-Aug;20(4):487-91 [10452592] Urology. 2005 Jun;65(6):1168-72 [15922427] Vitam Horm. 2005;71:373-404 [16112275] Prostate Cancer Prostatic Dis. 2006;9(1):19-24 [16344847] Obesity (Silver Spring). 2006 Feb;14(2):183-7 [16571841] Cancer Res. 2006 Apr 15;66(8):4525-30 [16618781] Cancer J. 2006 May-Jun;12(3):201-6 [16803678] Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1331-5 [16835332] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):308-13 [17301264] Nat Genet. 2007 May;39(5):645-9 [17401363] Front Biosci. 2007;12:3436-60 [17485312] Eur Urol. 2007 Jul;52(1):46-53 [17399889] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1291-3 [17548700] Nature. 2007 Oct 18;449(7164):851-61 [17943122] PLoS Med. 2007 Dec;4(12):e352 [18076282] Nat Genet. 2008 Mar;40(3):310-5 [18264096] Int J Obes Relat Metab Disord. 1998 Mar;22(3):200-5 [9539186] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.24043 ER - TY - CPAPER T1 - Solid State NMR of Amyloid Fibrils and Freeze-Trapped Protein Folding Intermediates T2 - 2009 Keystone Symposia on Frontiers of NMR in Biology (B8) AN - 41935575; 5115199 JF - 2009 Keystone Symposia on Frontiers of NMR in Biology (B8) AU - Tycko, Robert Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 KW - N.M.R. KW - Protein folding KW - Amyloid KW - Fibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41935575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Frontiers+of+NMR+in+Biology+%28B8%29&rft.atitle=Solid+State+NMR+of+Amyloid+Fibrils+and+Freeze-Trapped+Protein+Folding+Intermediates&rft.au=Tycko%2C+Robert&rft.aulast=Tycko&rft.aufirst=Robert&rft.date=2009-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Frontiers+of+NMR+in+Biology+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualizing Lowly-Populated Regions of the Free Energy Landscape of Macromolecular Complexes by Paramagnetic Relaxation Enhancement T2 - 2009 Keystone Symposia on Frontiers of NMR in Biology (B8) AN - 41911937; 5115210 JF - 2009 Keystone Symposia on Frontiers of NMR in Biology (B8) AU - Clore, Marius Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 KW - Landscape KW - Macromolecules KW - Free energy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Frontiers+of+NMR+in+Biology+%28B8%29&rft.atitle=Visualizing+Lowly-Populated+Regions+of+the+Free+Energy+Landscape+of+Macromolecular+Complexes+by+Paramagnetic+Relaxation+Enhancement&rft.au=Clore%2C+Marius&rft.aulast=Clore&rft.aufirst=Marius&rft.date=2009-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Frontiers+of+NMR+in+Biology+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combining RDC and Scattering Data for Structure Determination T2 - 2009 Keystone Symposia on Frontiers of NMR in Biology (B8) AN - 41910187; 5115206 JF - 2009 Keystone Symposia on Frontiers of NMR in Biology (B8) AU - Grishaev, Alexander Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41910187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Frontiers+of+NMR+in+Biology+%28B8%29&rft.atitle=Combining+RDC+and+Scattering+Data+for+Structure+Determination&rft.au=Grishaev%2C+Alexander&rft.aulast=Grishaev&rft.aufirst=Alexander&rft.date=2009-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Frontiers+of+NMR+in+Biology+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteins, Membranes, and their Interaction Viewed by NMR T2 - 2009 Keystone Symposia on Frontiers of NMR in Biology (B8) AN - 41908538; 5115188 JF - 2009 Keystone Symposia on Frontiers of NMR in Biology (B8) AU - Bax, Ad Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 KW - N.M.R. KW - Membranes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41908538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Frontiers+of+NMR+in+Biology+%28B8%29&rft.atitle=Proteins%2C+Membranes%2C+and+their+Interaction+Viewed+by+NMR&rft.au=Bax%2C+Ad&rft.aulast=Bax&rft.aufirst=Ad&rft.date=2009-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Frontiers+of+NMR+in+Biology+%28B8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=10 12 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - On the Role of RNA in retrovirus particle structure T2 - 2009 Gordon Research Conference on Physical Virology AN - 41905107; 5115455 JF - 2009 Gordon Research Conference on Physical Virology AU - Rein, Alan Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 KW - Particulates KW - Retrovirus KW - RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41905107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Physical+Virology&rft.atitle=On+the+Role+of+RNA+in+retrovirus+particle+structure&rft.au=Rein%2C+Alan&rft.aulast=Rein&rft.aufirst=Alan&rft.date=2009-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Physical+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=physviro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Charting the Structure and Energetics of Packaged DNA in Bacteriophages T2 - 2009 Gordon Research Conference on Physical Virology AN - 41900122; 5115460 JF - 2009 Gordon Research Conference on Physical Virology AU - Qiu, Xiangyun Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 KW - Phages KW - Bacteriophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Physical+Virology&rft.atitle=Charting+the+Structure+and+Energetics+of+Packaged+DNA+in+Bacteriophages&rft.au=Qiu%2C+Xiangyun&rft.aulast=Qiu&rft.aufirst=Xiangyun&rft.date=2009-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Physical+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=physviro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Dietary Glycemic Index, Glycemic Load, and Risk of Cancer: A Prospective Cohort Study AN - 20746023; 9145112 AB - Previous studies have provided limited evidence for a harmful effect of high glycemic index and dietary glycemic load on cancer. The authors analyzed associations among glycemic index, glycemic load, and risk of cancer in women and men in the National Institutes of Health-AARP Diet and Health Study. Published glycemic index values were assigned to 225 foods/food groups. Glycemic load was calculated by multiplying the glycemic index, carbohydrate content, and intake frequency of individual foods reported on a food frequency questionnaire. From 1995 through 2003, the authors identified 15,215 and 33,203 cancer cases in women and men, respectively. Cox proportional hazards models were used to estimate multivariate relative risks and 95% confidence intervals. For women and men, respectively, the relative risks for total cancer for high versus low glycemic index were 1.03 (Ptrend=0.217) and 1.04 (Ptrend=0.012) and, for glycemic load, were 0.90 (Ptrend=0.024) and 0.93 (Ptrend = 0.01). Associations with total cancer held only among the overweight for glycemic index and among those of healthy weight for glycemic load. These findings suggest that glycemic index and glycemic load are not strong predictors of cancer incidence. The direction and small magnitude of associations might be explained by the manner in which high glycemic index and glycemic load track with overall diet and lifestyle patterns. JF - American Journal of Epidemiology AU - George, Stephanie Materese AU - Mayne, Susan T AU - Leitzmann, Michael F AU - Park, Yikyung AU - Schatzkin, Arthur AU - Flood, Andrew AU - Hollenbeck, Albert AU - Subar, Amy F Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 462 EP - 472 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street VL - 169 IS - 4 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - diet KW - glycemic index KW - neoplasms KW - prospective studies KW - Diets KW - obesity KW - Carbohydrates KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20746023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Dietary+Glycemic+Index%2C+Glycemic+Load%2C+and+Risk+of+Cancer%3A+A+Prospective+Cohort+Study&rft.au=George%2C+Stephanie+Materese%3BMayne%2C+Susan+T%3BLeitzmann%2C+Michael+F%3BPark%2C+Yikyung%3BSchatzkin%2C+Arthur%3BFlood%2C+Andrew%3BHollenbeck%2C+Albert%3BSubar%2C+Amy+F&rft.aulast=George&rft.aufirst=Stephanie&rft.date=2009-02-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+Annual+Meeting+of+the+American+Society+of+Human+Genetics+%28ASHG+2008%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; obesity; Carbohydrates; Cancer DO - http://dx.doi.org/10.1093/aje/kwn347 ER - TY - JOUR T1 - bioDBnet: the biological database network AN - 20454020; 9145335 AB - Summary: bioDBnet is an online web resource that provides interconnected access to many types of biological databases. It has integrated many of the most commonly used biological databases and in its current state has 153 database identifiers (nodes) covering all aspects of biology including genes, proteins, pathways and other biological concepts. bioDBnet offers various ways to work with these databases including conversions, extensive database reports, custom navigation and has various tools to enhance the quality of the results. Importantly, the access to bioDBnet is updated regularly, providing access to the most recent releases of each individual database.Availability: http://biodbnet.abcc.ncifcrf.govContact: stephensratmail.nih.govSupplementary information: Supplementary data are available at Bioinformatics online JF - Bioinformatics AU - Mudunuri, Uma AU - Che, Anney AU - Yi, Ming AU - Stephens, Robert M AD - Advanced Biomedical Computing Center, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD 21702, USA Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 555 EP - 556 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 4 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Computer programs KW - Data processing KW - Bioinformatics KW - Nodes KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20454020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=bioDBnet%3A+the+biological+database+network&rft.au=Mudunuri%2C+Uma%3BChe%2C+Anney%3BYi%2C+Ming%3BStephens%2C+Robert+M&rft.aulast=Mudunuri&rft.aufirst=Uma&rft.date=2009-02-15&rft.volume=25&rft.issue=4&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn654 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; Data processing; Bioinformatics; Nodes; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btn654 ER - TY - JOUR T1 - Differential dependency network analysis to identify condition-specific topological changes in biological networks AN - 20453924; 9145315 AB - Motivation: Significant efforts have been made to acquire data under different conditions and to construct static networks that can explain various gene regulation mechanisms. However, gene regulatory networks are dynamic and condition-specific; under different conditions, networks exhibit different regulation patterns accompanied by different transcriptional network topologies. Thus, an investigation on the topological changes in transcriptional networks can facilitate the understanding of cell development or provide novel insights into the pathophysiology of certain diseases, and help identify the key genetic players that could serve as biomarkers or drug targets.Results: Here, we report a differential dependency network (DDN) analysis to detect statistically significant topological changes in the transcriptional networks between two biological conditions. We propose a local dependency model to represent the local structures of a network by a set of conditional probabilities. We develop an efficient learning algorithm to learn the local dependency model using the Lasso technique. A permutation test is subsequently performed to estimate the statistical significance of each learned local structure. In testing on a simulation dataset, the proposed algorithm accurately detected all the genes with network topological changes. The method was then applied to the estrogen-dependent T-47D estrogen receptor-positive (ER+) breast cancer cell line datasets and human and mouse embryonic stem cell datasets. In both experiments using real microarray datasets, the proposed method produced biologically meaningful results. We expect DDN to emerge as an important bioinformatics tool in transcriptional network analyses. While we focus specifically on transcriptional networks, the DDN method we introduce here is generally applicable to other biological networks with similar characteristics.Availability: The DDN MATLAB toolbox and experiment data are available at http://www.cbil.ece.vt.edu/software.htm.Contact: yuewangatvt.eduSupplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Zhang, Bai AU - Li, Huai AU - Riggins, Rebecca B AU - Zhan, Ming AU - Xuan, Jianhua AU - Zhang, Zhen AU - Hoffman, Eric P AU - Clarke, Robert AU - Wang, Yue AD - 1 Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, 2 Bioinformatics Unit, RRB, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, 3 Lombardi Comprehensive Cancer Center and Department of Oncology, Physiology and Biophysics, Georgetown University, Washington, DC 20057, 4 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231 and 5 Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 526 EP - 532 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 4 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Estrogens KW - Statistics KW - Data processing KW - Statistical analysis KW - Algorithms KW - Animal models KW - Transcription KW - Drug development KW - biomarkers KW - DNA microarrays KW - Computer programs KW - Tumor cell lines KW - Stem cells KW - Embryo cells KW - Gene regulation KW - Breast cancer KW - Learning algorithms KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20453924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Differential+dependency+network+analysis+to+identify+condition-specific+topological+changes+in+biological+networks&rft.au=Zhang%2C+Bai%3BLi%2C+Huai%3BRiggins%2C+Rebecca+B%3BZhan%2C+Ming%3BXuan%2C+Jianhua%3BZhang%2C+Zhen%3BHoffman%2C+Eric+P%3BClarke%2C+Robert%3BWang%2C+Yue&rft.aulast=Zhang&rft.aufirst=Bai&rft.date=2009-02-15&rft.volume=25&rft.issue=4&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn660 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Estrogens; Data processing; Statistics; Animal models; Algorithms; Statistical analysis; Transcription; Drug development; DNA microarrays; biomarkers; Computer programs; Stem cells; Tumor cell lines; Embryo cells; Gene regulation; Breast cancer; Bioinformatics; Learning algorithms DO - http://dx.doi.org/10.1093/bioinformatics/btn660 ER - TY - JOUR T1 - Non-negative matrix factorization of gene expression profiles: a plug-in for BRB-ArrayTools AN - 20449231; 9145314 AB - Summary: Non-negative matrix factorization (NMF) is an increasingly used algorithm for the analysis of complex high-dimensional data. BRB-ArrayTools is a widely used software system for the analysis of gene expression data with almost 9000 registered users in over 65 countries. We have developed a NMF analysis plug-in in BRB-ArrayTools for unsupervised sample clustering of microarray gene expression data. Our analysis tool also incorporates an algorithm for Semi-NMF which can handle both positive and negative elements for log-ratio data. Output includes a heat map of sample clusters and differentially expressed genes with extensive biological annotation. For comparison, output also includes the results of K-means clustering.Availability: The NMF analysis plug-in is freely available in BRB-ArrayTools for non-commercial users. BRB-ArrayTools can be downloaded at http://linus.nci.nih.gov/BRB-ArrayTools.html. The algorithms used for NMF and Semi-NMF are available at ftp://linus.nci.nih.gov/pub/NMF. JF - Bioinformatics AU - Qi, Qihao AU - Zhao, Yingdong AU - Li, MingChung AU - Simon, Richard AD - 1 Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, 3900 Reservoir Rd. NW, Washington, DC 20057-1455, 2 Biometric Research Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-7434 and 3 The EMMES Corporation, Rockville, MD 20850, USA, rsimon@mail.nih.gov Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 545 EP - 547 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 4 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - software KW - Data processing KW - Heat KW - Algorithms KW - Bioinformatics KW - DNA microarrays KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20449231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Non-negative+matrix+factorization+of+gene+expression+profiles%3A+a+plug-in+for+BRB-ArrayTools&rft.au=Qi%2C+Qihao%3BZhao%2C+Yingdong%3BLi%2C+MingChung%3BSimon%2C+Richard&rft.aulast=Qi&rft.aufirst=Qihao&rft.date=2009-02-15&rft.volume=25&rft.issue=4&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtp009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; software; Data processing; Heat; Algorithms; Bioinformatics; DNA microarrays DO - http://dx.doi.org/10.1093/bioinformatics/btp009 ER - TY - JOUR T1 - Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice AN - 20372068; 9045676 AB - Post-translational modification of proteins due to exposure to radicals and other reactive species are markers of metabolic and inflammatory oxidative stress such as sepsis. This study uses the nitrone spin-trap DMPO and a combination of immuno-spin trapping and mass spectrometry to identify in vivo products of radical reactions in mice. We report the detection of dose-dependent production of DMPO-carboxypeptidase B1 (CPB1) adducts in the spleens of mice treated with lipopolysaccharide (LPS). Additionally, we report significant detection of DMPO-CPB1 adducts in mice experiencing normal physiological conditions. Treatments with inhibitors and experiments with knock-out mice indicate that xanthine oxidase and endothelial nitric oxide synthase are important sources of the reactive species that lead to CPB1 adduct formation. We also report a significant loss of CPB1 activity following LPS challenge in conjunction with an increase in CPB1 protein accumulation. This suggests the presence of a possible mechanism for CPB1 activity loss with compensatory protein production. JF - Free Radical Biology and Medicine AU - Chatterjee, Saurabh AU - Ehrenshaft, Marilyn AU - Bhattacharjee, Suchandra AU - Deterding, Leesa J AU - Bonini, Marcelo G AU - Corbett, Jean AU - Kadiiska, Maria B AU - Tomer, Kenneth B AU - Mason, Ronald P AD - Free Radical Metabolites Group, Laboratory of Pharmacology, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., Research Triangle Park, North Carolina 27709, USA, chatterjees2@niehs.nih.gov Y1 - 2009/02/15/ PY - 2009 DA - 2009 Feb 15 SP - 454 EP - 461 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 46 IS - 4 SN - 0891-5849, 0891-5849 KW - Microbiology Abstracts B: Bacteriology KW - Oxidative stress KW - Immuno-spin trapping KW - Inflammation KW - Nitrone adduct KW - Carboxypeptidase A KW - Adducts KW - Spleen KW - Trapping KW - Mass spectroscopy KW - Nitric-oxide synthase KW - Sepsis KW - Post-translation KW - Xanthine oxidase KW - Lipopolysaccharides KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20372068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=Immuno-spin+trapping+of+a+post-translational+carboxypeptidase+B1+radical+formed+by+a+dual+role+of+xanthine+oxidase+and+endothelial+nitric+oxide+synthase+in+acute+septic+mice&rft.au=Chatterjee%2C+Saurabh%3BEhrenshaft%2C+Marilyn%3BBhattacharjee%2C+Suchandra%3BDeterding%2C+Leesa+J%3BBonini%2C+Marcelo+G%3BCorbett%2C+Jean%3BKadiiska%2C+Maria+B%3BTomer%2C+Kenneth+B%3BMason%2C+Ronald+P&rft.aulast=Chatterjee&rft.aufirst=Saurabh&rft.date=2009-02-15&rft.volume=46&rft.issue=4&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.10.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nitric-oxide synthase; Carboxypeptidase A; Sepsis; Post-translation; Oxidative stress; Adducts; Xanthine oxidase; Spleen; Lipopolysaccharides; Trapping; Mass spectroscopy; Inflammation DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.10.046 ER - TY - CPAPER T1 - Role of Brain Areas in the Development of PTSD T2 - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AN - 41940055; 5107928 JF - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AU - Grafman, Jordan Y1 - 2009/02/12/ PY - 2009 DA - 2009 Feb 12 KW - Brain KW - Post-traumatic stress disorder KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41940055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.atitle=Role+of+Brain+Areas+in+the+Development+of+PTSD&rft.au=Grafman%2C+Jordan&rft.aulast=Grafman&rft.aufirst=Jordan&rft.date=2009-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=8AA65090- 37AD-4C29-9CF1-9BCD6EFA2210&AKey=82DF1193-261B-4248-AC6B-CACD0186BD6 B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanomaterials in Human and Ecosystem Health T2 - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AN - 41897506; 5108269 JF - 2009 Annual Meeting of the American Association for the Advancement of Science (AAAS 2009) AU - Tinkle, Sally Y1 - 2009/02/12/ PY - 2009 DA - 2009 Feb 12 KW - Nanotechnology KW - Public health KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.atitle=Nanomaterials+in+Human+and+Ecosystem+Health&rft.au=Tinkle%2C+Sally&rft.aulast=Tinkle&rft.aufirst=Sally&rft.date=2009-02-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=8AA65090- 37AD-4C29-9CF1-9BCD6EFA2210&AKey=82DF1193-261B-4248-AC6B-CACD0186BD6 B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen. AN - 66884638; 19110021 AB - Tumor-associated antigens are weakly immunogenic. Human carcinoembryonic antigen (CEA) is overexpressed on a wide range of human carcinomas and represents an attractive target for cancer immunotherapy. This study analyzes the ability of a Saccharomyces cerevisiae vector containing the transgene encoding CEA (yeast-CEA) to activate human dendritic cells (DCs) and stimulate CEA-specific T-cell responses. We demonstrate for the first time that treatment with yeast-CEA can activate human DCs, resulting in increases in surface expression of CD80, CD83, CD54, CD58, and MHC class II, and increased production by DCs of IL-12p70, TNF-alpha, IFN-gamma, IL-8, IL-2, IL-13, IL-10, and IL-1beta. We also show that human DCs treated with yeast-CEA can activate CEA-specific T-cell lines and can act as antigen-presenting cells (APCs) to generate CEA-specific T-cell lines capable of lysing CEA(+) human tumor cells. Gene expression profiles of human DCs treated with yeast-CEA show increased expression of numerous genes involved in the production of chemokines and cytokines and their receptors, and genes related to antigen uptake, antigen presentation, and signal transduction. JF - Vaccine AU - Remondo, Cinzia AU - Cereda, Vittore AU - Mostböck, Sven AU - Sabzevari, Helen AU - Franzusoff, Alex AU - Schlom, Jeffrey AU - Tsang, Kwong-Y AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/02/11/ PY - 2009 DA - 2009 Feb 11 SP - 987 EP - 994 VL - 27 IS - 7 SN - 0264-410X, 0264-410X KW - Antigens, CD KW - 0 KW - Carcinoembryonic Antigen KW - Cytokines KW - Index Medicus KW - Lymphocyte Activation KW - Gene Expression Profiling KW - Antigens, CD -- analysis KW - Humans KW - Cytokines -- biosynthesis KW - Cytotoxicity Tests, Immunologic KW - T-Lymphocytes, Cytotoxic -- immunology KW - Cell Line, Tumor KW - Saccharomyces cerevisiae -- immunology KW - Saccharomyces cerevisiae -- genetics KW - Dendritic Cells -- chemistry KW - Dendritic Cells -- immunology KW - Carcinoembryonic Antigen -- biosynthesis KW - Carcinoembryonic Antigen -- immunology KW - Carcinoembryonic Antigen -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66884638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Human+dendritic+cell+maturation+and+activation+by+a+heat-killed+recombinant+yeast+%28Saccharomyces+cerevisiae%29+vector+encoding+carcinoembryonic+antigen.&rft.au=Remondo%2C+Cinzia%3BCereda%2C+Vittore%3BMostb%C3%B6ck%2C+Sven%3BSabzevari%2C+Helen%3BFranzusoff%2C+Alex%3BSchlom%2C+Jeffrey%3BTsang%2C+Kwong-Y&rft.aulast=Remondo&rft.aufirst=Cinzia&rft.date=2009-02-11&rft.volume=27&rft.issue=7&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-16 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2005 Aug 1;11(15):5603-15 [16061879] Clin Cancer Res. 2005 Feb 15;11(4):1597-607 [15746065] Cell Microbiol. 2006 Apr;8(4):602-12 [16548886] Nature. 2006 Apr 6;440(7085):808-12 [16489357] J Clin Immunol. 2006 May;26(3):251-64 [16783464] Vaccine. 2006 Sep 11;24(37-39):6272-81 [16860448] Vaccine. 2007 Feb 9;25(8):1452-63 [17098335] Hum Immunol. 2007 May;68(5):324-33 [17462499] Clin Cancer Res. 2007 Aug 15;13(16):4677-85 [17699845] Vaccine. 2008 Jan 24;26(4):509-21 [18155327] Cancer Res. 1999 Nov 15;59(22):5800-7 [10582702] Int J Cancer. 2000 Mar 15;85(6):829-38 [10709104] J Biol Chem. 2000 Jul 7;275(27):20861-6 [10877845] J Immunol. 2000 Oct 1;165(7):3804-10 [11034386] J Immunol. 2001 Jan 1;166(1):249-55 [11123299] Springer Semin Immunopathol. 2000;22(4):345-69 [11155441] Cancer Res. 2001 May 1;61(9):3725-34 [11325845] Nat Med. 2001 May;7(5):625-9 [11329066] Cancer Res. 2001 Oct 15;61(20):7568-76 [11606396] Clin Exp Allergy. 2001 Oct;31(10):1583-93 [11678859] Science. 2001 Oct 26;294(5543):870-5 [11679675] Microbiol Immunol. 2002;46(7):503-12 [12222939] Clin Cancer Res. 2003 May;9(5):1616-27 [12738714] APMIS. 2003 Jul-Aug;111(7-8):789-96 [12974780] Cytokine. 2003 Nov 21;24(4):128-42 [14572791] Trends Microbiol. 2004 Jan;12(1):44-9 [14700551] Annu Rev Immunol. 1989;7:445-80 [2653373] J Immunol. 1990 Jun 15;144(12):4579-86 [1972160] Clin Microbiol Rev. 1991 Jan;4(1):1-19 [2004345] J Exp Med. 1994 Apr 1;179(4):1109-18 [8145033] J Natl Cancer Inst. 1995 Jul 5;87(13):982-90 [7629885] Blood. 1996 Aug 15;88(4):1147-55 [8695831] Curr Opin Immunol. 1996 Aug;8(4):531-6 [8794021] Res Immunol. 1995 Sep-Oct;146(7-8):423-31 [8839141] Cancer Gene Ther. 1997 Jan-Feb;4(1):17-25 [9012447] Blood. 1997 Sep 15;90(6):2160-7 [9310466] Hum Gene Ther. 1997 Sep 20;8(14):1651-8 [9322867] Cancer Res. 1997 Oct 15;57(20):4570-7 [9377571] Nature. 1998 Mar 19;392(6673):245-52 [9521319] J Exp Med. 1998 Jun 15;187(12):2097-101 [9625770] Cancer Gene Ther. 1998 Jul-Aug;5(4):236-46 [9694075] Clin Cancer Res. 1997 Dec;3(12 Pt 1):2439-49 [9815645] Cancer Gene Ther. 1998 Nov-Dec;5(6):350-6 [9917089] Blood. 1999 Jun 1;93(11):3610-6 [10339465] J Leukoc Biol. 1999 Aug;66(2):252-62 [10449163] BMC Immunol. 2005;6:17 [16026627] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2008.12.002 ER - TY - JOUR T1 - Colorectal cancer risk prediction tool for white men and women without known susceptibility. AN - 66898160; 19114701 AB - Given the high incidence of colorectal cancer (CRC), and the availability of procedures that can detect disease and remove precancerous lesions, there is a need for a model that estimates the probability of developing CRC across various age intervals and risk factor profiles. The development of separate CRC absolute risk models for men and women included estimating relative risks and attributable risk parameters from population-based case-control data separately for proximal, distal, and rectal cancer and combining these estimates with baseline age-specific cancer hazard rates based on Surveillance, Epidemiology, and End Results (SEER) incidence rates and competing mortality risks. For men, the model included a cancer-negative sigmoidoscopy/colonoscopy in the last 10 years, polyp history in the last 10 years, history of CRC in first-degree relatives, aspirin and nonsteroidal anti-inflammatory drug (NSAID) use, cigarette smoking, body mass index (BMI), current leisure-time vigorous activity, and vegetable consumption. For women, the model included sigmoidoscopy/colonoscopy, polyp history, history of CRC in first-degree relatives, aspirin and NSAID use, BMI, leisure-time vigorous activity, vegetable consumption, hormone-replacement therapy (HRT), and estrogen exposure on the basis of menopausal status. For men and women, relative risks differed slightly by tumor site. A validation study in independent data indicates that the models for men and women are well calibrated. We developed absolute risk prediction models for CRC from population-based data, and a simple questionnaire suitable for self-administration. This model is potentially useful for counseling, for designing research intervention studies, and for other applications. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Freedman, Andrew N AU - Slattery, Martha L AU - Ballard-Barbash, Rachel AU - Willis, Gordon AU - Cann, Bette J AU - Pee, David AU - Gail, Mitchell H AU - Pfeiffer, Ruth M AD - Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, EPN 4005 MSC 7344, Bethesda, MD 20892-7344, USA. Andrew_Freedman@nih.gov Y1 - 2009/02/10/ PY - 2009 DA - 2009 Feb 10 SP - 686 EP - 693 VL - 27 IS - 5 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Index Medicus KW - Humans KW - Aged KW - Body Mass Index KW - Sigmoidoscopy KW - Colonoscopy KW - Leisure Activities KW - Intestinal Polyps KW - Risk Factors KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - European Continental Ancestry Group KW - Middle Aged KW - Diet KW - Female KW - Male KW - Proportional Hazards Models KW - Models, Theoretical KW - Colorectal Neoplasms -- etiology KW - Colorectal Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66898160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Colorectal+cancer+risk+prediction+tool+for+white+men+and+women+without+known+susceptibility.&rft.au=Freedman%2C+Andrew+N%3BSlattery%2C+Martha+L%3BBallard-Barbash%2C+Rachel%3BWillis%2C+Gordon%3BCann%2C+Bette+J%3BPee%2C+David%3BGail%2C+Mitchell+H%3BPfeiffer%2C+Ruth+M&rft.aulast=Freedman&rft.aufirst=Andrew&rft.date=2009-02-10&rft.volume=27&rft.issue=5&rft.spage=686&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.17.4797 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-26 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1999 Jun 2;91(11):916-32 [10359544] Ann Epidemiol. 1997 Feb;7(2):137-45 [9099401] J Natl Cancer Inst. 2005 May 18;97(10):715-23 [15900041] Biometrics. 2005 Sep;61(3):847-55 [16135037] Gastroenterology. 2006 May;130(6):1872-85 [16697750] J Clin Oncol. 2006 Aug 1;24(22):3590-6 [16728488] Am J Med. 2007 Mar;120(3):257-63 [17349449] J Natl Cancer Inst. 2007 May 2;99(9):715-26 [17470739] Am J Epidemiol. 2007 Oct 1;166(7):832-40 [17670910] J Clin Oncol. 2007 Nov 1;25(31):4974-81 [17971596] J Natl Cancer Inst. 2007 Dec 5;99(23):1782-92 [18042936] CA Cancer J Clin. 2008 May-Jun;58(3):130-60 [18322143] J Clin Oncol. 2009 Feb 10;27(5):694-8 [19114700] Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1117-21 [10613347] Cancer Causes Control. 2000 Jul;11(6):477-88 [10880030] Cancer Causes Control. 2000 Jul;11(6):555-63 [10880038] Gastroenterology. 2001 Apr;120(5):1077-83 [11266371] Lancet. 2002 Jul 27;360(9329):278-83 [12147370] Gastroenterol Clin North Am. 2002 Dec;31(4):925-43 [12489270] Nutr Cancer. 2002;43(2):121-6 [12588690] J Natl Cancer Inst. 2003 Mar 19;95(6):470-8 [12644540] Cancer Causes Control. 2003 Feb;14(1):75-84 [12708728] Ann Intern Med. 2003 Dec 16;139(12):959-65 [14678915] Nutr Cancer. 2003;46(2):166-71 [14690792] Am J Epidemiol. 2004 Jan 1;159(1):32-41 [14693657] Am J Clin Nutr. 2004 Feb;79(2):274-81 [14749234] J Natl Cancer Inst. 2004 Feb 4;96(3):218-28 [14759989] Dis Colon Rectum. 2004 Mar;47(3):323-33 [14991494] Sports Med. 2004;34(4):239-52 [15049716] Am J Epidemiol. 1989 Sep;130(3):522-9 [2763997] J Natl Cancer Inst. 1989 Dec 20;81(24):1879-86 [2593165] J Natl Cancer Inst. 1991 Sep 18;83(18):1324-9 [1886158] Ann Intern Med. 1993 May 15;118(10):785-90 [8470852] Breast Cancer Res Treat. 1993 Nov;28(2):115-20 [8173064] N Engl J Med. 1994 Dec 22;331(25):1669-74 [7969357] J Natl Cancer Inst. 1996 Dec 4;88(23):1717-30 [8944002] Int J Cancer. 1997 Jan 27;70(3):259-64 [9033624] Cancer Causes Control. 1999 Jun;10(3):167-80 [10454062] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2008.17.4797 ER - TY - JOUR T1 - Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. AN - 66896838; 19114704 AB - To evaluate single-agent activity of bevacizumab in patients with recurrent glioblastoma. Patients with recurrent glioblastoma were treated with bevacizumab 10 mg/kg every 2 weeks. After tumor progression, patients were immediately treated with bevacizumab in combination with irinotecan 340 mg/m(2) or 125 mg/m(2) every 2 weeks, depending on use of enzyme-inducing antiepileptic drugs. Complete patient evaluations were repeated every 4 weeks. Forty-eight heavily pretreated patients were accrued to this study. Thromboembolic events (12.5%), hypertension (12.5%), hypophosphatemia (6%), and thrombocytopenia (6%) were the most common drug-associated adverse events. Six patients (12.5%) were removed from study for drug-associated toxicity (five thromboembolic events, one bowel perforation). Thirty-four patients (71%) and 17 patients (35%) achieved radiographic response based on Levin and Macdonald criteria, respectively. Median progression-free survival (PFS) was 16 weeks (95% CI, 12 to 26 weeks). The 6-month PFS was 29% (95% CI, 18% to 48%). The 6-month overall survival was 57% (95% CI, 44% to 75%). Median overall survival was 31 weeks (95% CI, 21 to 54 weeks). Early magnetic resonance imaging response (first 96 hours and 4 weeks) was predictive of long-term PFS, with the Levin criteria being more predictive than Macdonald criteria. Of 19 patients treated with bevacizumab plus irinotecan at progression, there were no objective radiographic responses. Eighteen patients (95%) experienced disease progression by the second cycle, and the median PFS was 30 days. We conclude that single-agent bevacizumab has significant biologic and antiglioma activity in patients with recurrent glioblastoma. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Kreisl, Teri N AU - Kim, Lyndon AU - Moore, Kraig AU - Duic, Paul AU - Royce, Cheryl AU - Stroud, Irene AU - Garren, Nancy AU - Mackey, Megan AU - Butman, John A AU - Camphausen, Kevin AU - Park, John AU - Albert, Paul S AU - Fine, Howard A AD - Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-8200, USA. Y1 - 2009/02/10/ PY - 2009 DA - 2009 Feb 10 SP - 740 EP - 745 VL - 27 IS - 5 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Antineoplastic Agents, Phytogenic KW - irinotecan KW - 0H43101T0J KW - Bevacizumab KW - 2S9ZZM9Q9V KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Disease-Free Survival KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Glioblastoma -- mortality KW - Antineoplastic Agents -- administration & dosage KW - Brain Neoplasms -- mortality KW - Glioblastoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antibodies, Monoclonal -- administration & dosage KW - Camptothecin -- administration & dosage KW - Antibodies, Monoclonal -- therapeutic use KW - Brain Neoplasms -- drug therapy KW - Antibodies, Monoclonal -- toxicity KW - Camptothecin -- analogs & derivatives KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antineoplastic Agents, Phytogenic -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66896838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+II+trial+of+single-agent+bevacizumab+followed+by+bevacizumab+plus+irinotecan+at+tumor+progression+in+recurrent+glioblastoma.&rft.au=Kreisl%2C+Teri+N%3BKim%2C+Lyndon%3BMoore%2C+Kraig%3BDuic%2C+Paul%3BRoyce%2C+Cheryl%3BStroud%2C+Irene%3BGarren%2C+Nancy%3BMackey%2C+Megan%3BButman%2C+John+A%3BCamphausen%2C+Kevin%3BPark%2C+John%3BAlbert%2C+Paul+S%3BFine%2C+Howard+A&rft.aulast=Kreisl&rft.aufirst=Teri&rft.date=2009-02-10&rft.volume=27&rft.issue=5&rft.spage=740&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.16.3055 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-26 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1999 Aug;17(8):2572-8 [10561324] J Neurooncol. 2001 Nov;55(2):91-100 [11817706] Jpn J Clin Oncol. 2003 Oct;33(10):533-7 [14623923] Semin Oncol. 2003 Dec;30(6 Suppl 19):10-4 [14765378] Neuro Oncol. 2004 Jan;6(1):21-7 [14769136] Neuro Oncol. 2004 Jul;6(3):227-35 [15279715] J Neurosurg. 1977 Sep;47(3):329-35 [894339] J Clin Oncol. 1990 Jul;8(7):1277-80 [2358840] Cancer Res. 1991 Feb 15;51(4):1345-51 [1705174] J Neurosurg. 1992 May;76(5):792-8 [1564542] N Engl J Med. 2005 Mar 10;352(10):987-96 [15758009] Lancet Oncol. 2005 May;6(5):266 [15889502] J Clin Oncol. 2005 May 20;23(15):3502-8 [15908660] Eur J Cancer. 2005 Jul;41(10):1426-30 [15919202] Neuro Oncol. 2006 Apr;8(2):189-93 [16533878] Curr Opin Oncol. 2006 Nov;18(6):644-7 [16988588] Neuro Oncol. 2007 Jan;9(1):29-38 [17108063] Clin Cancer Res. 2007 Feb 15;13(4):1253-9 [17317837] J Clin Oncol. 2007 Oct 20;25(30):4722-9 [17947719] Neuro Oncol. 2008 Apr;10(2):162-70 [18356283] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2008.16.3055 ER - TY - JOUR T1 - Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis AN - 20433597; 9118327 AB - Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N = 182), gastric cardia (N = 178), and oesophageal adenocarcinomas (N = 228) in a prospective cohort (N = 311 115) followed for 7 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) come from Cox models adjusted for potential confounders. Use of any aspirin (HR, 95% CI: 0.64, 0.47-0.86) or other NSAIDs (0.68, 0.51-0.92) was associated with a significantly lower risk of gastric non-cardia adenocarcinoma Neither aspirin (0.86, 0.61-1.20) nor other NSAIDs (0.91, 0.67-1.22) had a significant association with gastric cardia cancer. We found no significant association between using aspirin (1.00, 0.73-1.37) or other NSAIDs (0.90, 69-1.17) and oesophageal adenocarcinoma. We also performed a meta-analysis of the association between the use of NSAIDs and risk of gastric and oesophageal adenocarcinoma. In this analysis, aspirin use was inversely associated with both gastric and oesophageal adenocarcinomas, with summary odds ratios (95% CI) for non-cardia, cardia, and oesophageal adenocarcinomas of 0.64 (0.52-0.80), 0.82 (0.65-1.04), and 0.64 (0.52-0.79), respectively. The corresponding numbers for other NSAIDs were 0.68 (0.57-0.81), 0.80 (0.67-0.95), and 0.65 (0.50-0.85), respectively. JF - British Journal of Cancer AU - Abnet, C C AU - Freedman, N D AU - Kamangar, F AU - Leitzmann, M F AU - Hollenbeck, A R AU - Schatzkin, A AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 320, 6120 Executive Blvd, MSC 7232, Rockville, MD 20852, USA, abnetc@mail.nih.gov Y1 - 2009/02/10/ PY - 2009 DA - 2009 Feb 10 SP - 551 EP - 557 VL - 100 IS - 3 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - aspirin KW - risk reduction KW - antiinflammatory agents KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20433597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Non-steroidal+anti-inflammatory+drugs+and+risk+of+gastric+and+oesophageal+adenocarcinomas%3A+results+from+a+cohort+study+and+a+meta-analysis&rft.au=Abnet%2C+C+C%3BFreedman%2C+N+D%3BKamangar%2C+F%3BLeitzmann%2C+M+F%3BHollenbeck%2C+A+R%3BSchatzkin%2C+A&rft.aulast=Abnet&rft.aufirst=C&rft.date=2009-02-10&rft.volume=100&rft.issue=3&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604880 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - risk reduction; aspirin; antiinflammatory agents; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6604880 ER - TY - JOUR T1 - Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r AN - 20241171; 10314237 AB - The melanocortin-1 receptor (MC1R) is a key regulator of pigmentation in mammals and is tightly linked to an increased risk of skin cancers, including melanoma, in humans. Physiologically activated by alpha -melanocyte stimulating hormone ( alpha MSH), MC1R function can be antagonized by a secreted factor, agouti signal protein (ASP), which is responsible for the lighter phenotypes in mammals (including humans), and is also associated with increased risk of skin cancer. It is therefore of great interest to characterize the molecular effects elicited by those MC1R ligands. In this study, we determined the gene expression profiles of murine melan-a melanocytes treated with ASP or alpha MSH over a 4-day time course using genome-wide oligonucleotide microarrays. As expected, there were significant reductions in expression of numerous melanogenic proteins elicited by ASP, which correlates with its inhibition of pigmentation. ASP also unexpectedly modulated the expression of genes involved in various other cellular pathways, including glutathione synthesis and redox metabolism. Many genes up-regulated by ASP are involved in morphogenesis (especially in nervous system development), cell adhesion, and extracellular matrix-receptor interactions. Concomitantly, ASP enhanced the migratory potential and the invasiveness of melanocytic cells in vitro. These results demonstrate the role of ASP in the dedifferentiation of melanocytes, identify pigment-related genes targeted by ASP and by alpha MSH, and provide insights into the pleiotropic molecular effects of MC1R signaling that may function during development and may affect skin cancer risk. JF - Proceedings of the National Academy of Sciences, USA AU - Le Pape, Elodie AU - Passeron, Thierry AU - Giubellino, Alessio AU - Valencia, Julio C AU - Wolber, Rainer AU - Hearing, Vincent J Y1 - 2009/02/10/ PY - 2009 DA - 2009 Feb 10 SP - 1802 EP - 1807 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 6 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts KW - pigmentation KW - skin cancer KW - Pigmentation KW - Invasiveness KW - Glutathione KW - Morphogenesis KW - Skin cancer KW - Melanocytes KW - Development KW - Hormones KW - Oligonucleotides KW - alpha -Melanocyte-stimulating hormone KW - Cell adhesion KW - Melanoma KW - Gene expression KW - Nervous system KW - Cell migration KW - Metabolism KW - Signal transduction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20241171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Microarray+analysis+sheds+light+on+the+dedifferentiating+role+of+agouti+signal+protein+in+murine+melanocytes+via+the+Mc1r&rft.au=Le+Pape%2C+Elodie%3BPasseron%2C+Thierry%3BGiubellino%2C+Alessio%3BValencia%2C+Julio+C%3BWolber%2C+Rainer%3BHearing%2C+Vincent+J&rft.aulast=Le+Pape&rft.aufirst=Elodie&rft.date=2009-02-10&rft.volume=106&rft.issue=6&rft.spage=1802&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0806753106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Pigmentation; Invasiveness; Glutathione; Morphogenesis; Skin cancer; Development; Melanocytes; alpha -Melanocyte-stimulating hormone; Oligonucleotides; Hormones; Melanoma; Cell adhesion; Gene expression; Nervous system; Cell migration; Metabolism; Signal transduction DO - http://dx.doi.org/10.1073/pnas.0806753106 ER - TY - CPAPER T1 - T Cell Control of Cancer T2 - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AN - 41930654; 5114468 JF - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AU - Restifo, Nicholas Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Cancer KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41930654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.atitle=T+Cell+Control+of+Cancer&rft.au=Restifo%2C+Nicholas&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recognition of Damaged DNA Bases T2 - 2009 Gordon Research Conference on Mammalian DNA Repair AN - 41914919; 5115655 JF - 2009 Gordon Research Conference on Mammalian DNA Repair AU - Yang, Wei Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - DNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41914919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mammalian+DNA+Repair&rft.atitle=Recognition+of+Damaged+DNA+Bases&rft.au=Yang%2C+Wei&rft.aulast=Yang&rft.aufirst=Wei&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mammalian+DNA+Repair&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mammdna LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Approaches to Prevent and Recover Salivary Glands from Irradiation Damage T2 - 7th Gordon Research Conference on Salivary Glands and Exocrine Secretion AN - 41911801; 5115307 JF - 7th Gordon Research Conference on Salivary Glands and Exocrine Secretion AU - Cotrim, Ana Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Irradiation KW - Radiation KW - Salivary gland KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Gordon+Research+Conference+on+Salivary+Glands+and+Exocrine+Secretion&rft.atitle=Approaches+to+Prevent+and+Recover+Salivary+Glands+from+Irradiation+Damage&rft.au=Cotrim%2C+Ana&rft.aulast=Cotrim&rft.aufirst=Ana&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Gordon+Research+Conference+on+Salivary+Glands+and+Exocrine+Secretion&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=salivary LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Approaches to Study the Dynamics of Endocytosis and Exocytosis in the Salivary Glands of Live Rodents by Using Intravital Two-Photon Microscopy T2 - 7th Gordon Research Conference on Salivary Glands and Exocrine Secretion AN - 41911766; 5115294 JF - 7th Gordon Research Conference on Salivary Glands and Exocrine Secretion AU - Weigert, Roberto Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Microscopy KW - Rodents KW - Salivary gland KW - Exocytosis KW - Endocytosis KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+Gordon+Research+Conference+on+Salivary+Glands+and+Exocrine+Secretion&rft.atitle=Novel+Approaches+to+Study+the+Dynamics+of+Endocytosis+and+Exocytosis+in+the+Salivary+Glands+of+Live+Rodents+by+Using+Intravital+Two-Photon+Microscopy&rft.au=Weigert%2C+Roberto&rft.aulast=Weigert&rft.aufirst=Roberto&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+Gordon+Research+Conference+on+Salivary+Glands+and+Exocrine+Secretion&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=salivary LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of 53BP1 in long range end joining T2 - 2009 Gordon Research Conference on Mammalian DNA Repair AN - 41908332; 5115633 JF - 2009 Gordon Research Conference on Mammalian DNA Repair AU - Nussenzweig, Andre Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41908332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mammalian+DNA+Repair&rft.atitle=Role+of+53BP1+in+long+range+end+joining&rft.au=Nussenzweig%2C+Andre&rft.aulast=Nussenzweig&rft.aufirst=Andre&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mammalian+DNA+Repair&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mammdna LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Unique Immunogenicity Profile of Aerosol Vaccination in Nonhuman Primates T2 - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AN - 41906413; 5114438 JF - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AU - Roederer, Mario Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Immunogenicity KW - Aerosols KW - Primates KW - Vaccination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41906413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.atitle=The+Unique+Immunogenicity+Profile+of+Aerosol+Vaccination+in+Nonhuman+Primates&rft.au=Roederer%2C+Mario&rft.aulast=Roederer&rft.aufirst=Mario&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Active and Passive Immunization Against Avian Influenza Viruses T2 - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AN - 41906179; 5114470 JF - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AU - Subbarao, Kanta Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Immunization KW - Influenza KW - Viruses KW - Immunization (passive) KW - Fowl plague KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41906179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.atitle=Active+and+Passive+Immunization+Against+Avian+Influenza+Viruses&rft.au=Subbarao%2C+Kanta&rft.aulast=Subbarao&rft.aufirst=Kanta&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of PCNA ubiquitination T2 - 2009 Gordon Research Conference on Mammalian DNA Repair AN - 41905224; 5115641 JF - 2009 Gordon Research Conference on Mammalian DNA Repair AU - Myung, K Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Proliferating cell nuclear antigen KW - Ubiquitination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41905224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Mammalian+DNA+Repair&rft.atitle=Regulation+of+PCNA+ubiquitination&rft.au=Myung%2C+K&rft.aulast=Myung&rft.aufirst=K&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Mammalian+DNA+Repair&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=mammdna LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue-Specific Differences and T Cell Loss in HIV Infection T2 - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AN - 41904480; 5114446 JF - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AU - Douek, Daniel Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Human immunodeficiency virus KW - Infection KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.atitle=Tissue-Specific+Differences+and+T+Cell+Loss+in+HIV+Infection&rft.au=Douek%2C+Daniel&rft.aulast=Douek&rft.aufirst=Daniel&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Priming of CD4+ T Cells with Protein and Poly I:C Increases Subsequent Boosting of CD8+ but not CD4+ T Cell Responses T2 - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AN - 41902670; 5114441 JF - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AU - Quinn, Kylie Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Lymphocytes T KW - CD4 antigen KW - CD8 antigen KW - Poly (I:C) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.atitle=Priming+of+CD4%2B+T+Cells+with+Protein+and+Poly+I%3AC+Increases+Subsequent+Boosting+of+CD8%2B+but+not+CD4%2B+T+Cell+Responses&rft.au=Quinn%2C+Kylie&rft.aulast=Quinn&rft.aufirst=Kylie&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deconvoluting Adaptive T Cell Immunity: Clonotype Selection and Biological Outcome T2 - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AN - 41900525; 5114462 JF - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AU - Price, David Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Lymphocytes T KW - Immunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.atitle=Deconvoluting+Adaptive+T+Cell+Immunity%3A+Clonotype+Selection+and+Biological+Outcome&rft.au=Price%2C+David&rft.aulast=Price&rft.aufirst=David&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Innate Influence on the Quality of T Cell Responses T2 - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AN - 41891177; 5114417 JF - 2009 Keystone Symposia on Immunologic Memory and Host Defense (B6) AU - Seder, Robert Y1 - 2009/02/08/ PY - 2009 DA - 2009 Feb 08 KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41891177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.atitle=Innate+Influence+on+the+Quality+of+T+Cell+Responses&rft.au=Seder%2C+Robert&rft.aulast=Seder&rft.aufirst=Robert&rft.date=2009-02-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Immunologic+Memory+and+Host+Defense+%28B6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-performance computer aided detection system for polyp detection in CT colonography with fl uid and fecal tagging T2 - 2009 Conference on Computer-Aided Diagnosis (MI103) AN - 41746237; 5011032 JF - 2009 Conference on Computer-Aided Diagnosis (MI103) AU - Liu, Jiamin AU - Wang, Shijun AU - Kabadi, Suraj AU - Summers, Ronald Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Fecal coliforms KW - Polyps KW - Computers KW - Tagging KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41746237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.atitle=High-performance+computer+aided+detection+system+for+polyp+detection+in+CT+colonography+with+fl+uid+and+fecal+tagging&rft.au=Liu%2C+Jiamin%3BWang%2C+Shijun%3BKabadi%2C+Suraj%3BSummers%2C+Ronald&rft.aulast=Liu&rft.aufirst=Jiamin&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x12534&ID=x12171&redir=x12171.xml&conference_id=863802&event_ id=861972&jsenabled=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Segmentation propagation for the automated quantifi cation of ventricle volume from serial MRI T2 - 2009 Conference on Computer-Aided Diagnosis (MI103) AN - 41744445; 5010937 JF - 2009 Conference on Computer-Aided Diagnosis (MI103) AU - Linguraru, Marius AU - Butman, John Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Cations KW - Ventricle KW - Magnetic resonance imaging KW - Segmentation KW - Image processing KW - Automation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41744445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.atitle=Segmentation+propagation+for+the+automated+quantifi+cation+of+ventricle+volume+from+serial+MRI&rft.au=Linguraru%2C+Marius%3BButman%2C+John&rft.aulast=Linguraru&rft.aufirst=Marius&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x12534&ID=x12171&redir=x12171.xml&conference_id=863802&event_ id=861972&jsenabled=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two methods of Haustral fold detection from computed tomographic virtual colonoscopy images T2 - 2009 Conference on Computer-Aided Diagnosis (MI103) AN - 41733248; 5010969 JF - 2009 Conference on Computer-Aided Diagnosis (MI103) AU - Chowdhury, Ananda AU - Tan, Sovira AU - Yao, Jianhua AU - Linguraru, Marius AU - Summers, Ronald Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Colon KW - Computed tomography KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41733248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.atitle=Two+methods+of+Haustral+fold+detection+from+computed+tomographic+virtual+colonoscopy+images&rft.au=Chowdhury%2C+Ananda%3BTan%2C+Sovira%3BYao%2C+Jianhua%3BLinguraru%2C+Marius%3BSummers%2C+Ronald&rft.aulast=Chowdhury&rft.aufirst=Ananda&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x12534&ID=x12171&redir=x12171.xml&conference_id=863802&event_ id=861972&jsenabled=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical image processing engine T2 - 2009 Conference on Advanced PACS-based Imaging Informatics and Image-Guided Therapy (MI107) AN - 41732463; 5011677 JF - 2009 Conference on Advanced PACS-based Imaging Informatics and Image-Guided Therapy (MI107) AU - Han, Wei AU - Yao, Jianhua AU - Chen, Jeremy AU - Summers, Ronald Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Image processing KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41732463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Advanced+PACS-based+Imaging+Informatics+and+Image-Guided+Therapy+%28MI107%29&rft.atitle=Clinical+image+processing+engine&rft.au=Han%2C+Wei%3BYao%2C+Jianhua%3BChen%2C+Jeremy%3BSummers%2C+Ronald&rft.aulast=Han&rft.aufirst=Wei&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Advanced+PACS-based+Imaging+Informatics+and+Image-Guided+Therapy+%28MI107%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging2009-F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combining heterogeneous features for colonic polyp detection in CTC based on semi-defi nite programming T2 - 2009 Conference on Computer-Aided Diagnosis (MI103) AN - 41732043; 5010966 JF - 2009 Conference on Computer-Aided Diagnosis (MI103) AU - Wang, Shijun AU - Yao, Jianhua AU - Summers, Ronald AU - . Petrick, Nicholas Y1 - 2009/02/07/ PY - 2009 DA - 2009 Feb 07 KW - Polyps KW - Planning KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41732043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.atitle=Combining+heterogeneous+features+for+colonic+polyp+detection+in+CTC+based+on+semi-defi+nite+programming&rft.au=Wang%2C+Shijun%3BYao%2C+Jianhua%3BSummers%2C+Ronald%3B.+Petrick%2C+Nicholas&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2009-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Computer-Aided+Diagnosis+%28MI103%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org//app/program/index.cfm?fuseaction=conferencedetail&exp ort_id=x12534&ID=x12171&redir=x12171.xml&conference_id=863802&event_ id=861972&jsenabled=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A binding domain on mesothelin for CA125/MUC16. AN - 66871558; 19075018 AB - Ovarian cancer and malignant mesothelioma frequently express both mesothelin and CA125 (also known as MUC16) at high levels on the cell surface. The interaction between mesothelin and CA125 may facilitate the implantation and peritoneal spread of tumors by cell adhesion, whereas the detailed nature of this interaction is still unknown. Here, we used truncated mutagenesis and alanine replacement techniques to identify a binding site on mesothelin for CA125. We examined the molecular interaction by Western blot overlay assays and further quantitatively analyzed by enzyme-linked immunosorbent assay. We also evaluated the binding on cancer cells by flow cytometry. We identified the region (296-359) consisting of 64 amino acids at the N-terminal of cell surface mesothelin as the minimum fragment for complete binding activity to CA125. We found that substitution of tyrosine 318 with an alanine abolished CA125 binding. Replacement of tryptophan 321 and glutamic acid 324 with alanine could partially decrease binding to CA125, whereas mutation of histidine 354 had no effect. These results indicate that a conformation-sensitive structure of the region (296-359) is required and sufficient for the binding of mesothelin to CA125. In addition, we have shown that a single chain monoclonal antibody (SS1) recognizes this CA125-binding domain and blocks the mesothelin-CA125 interaction on cancer cells. The identified CA125-binding domain significantly inhibits cancer cell adhesion and merits evaluation as a new therapeutic agent for preventing or treating peritoneal malignant tumors. JF - The Journal of biological chemistry AU - Kaneko, Osamu AU - Gong, Lucy AU - Zhang, Jingli AU - Hansen, Johanna K AU - Hassan, Raffit AU - Lee, Byungkook AU - Ho, Mitchell AD - Laboratory of Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/02/06/ PY - 2009 DA - 2009 Feb 06 SP - 3739 EP - 3749 VL - 284 IS - 6 SN - 0021-9258, 0021-9258 KW - Antibodies, Monoclonal KW - 0 KW - CA-125 Antigen KW - GPI-Linked Proteins KW - MUC16 protein, human KW - Membrane Glycoproteins KW - Membrane Proteins KW - Neoplasm Proteins KW - mesothelin KW - Index Medicus KW - Peptide Mapping -- methods KW - Humans KW - Cell Adhesion -- genetics KW - Cell Line, Tumor KW - Antibodies, Monoclonal -- pharmacology KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Mutagenesis KW - Protein Structure, Tertiary -- genetics KW - Protein Binding -- drug effects KW - Protein Binding -- genetics KW - Binding Sites -- genetics KW - Cell Adhesion -- drug effects KW - Amino Acid Substitution KW - Female KW - Gene Expression Regulation, Neoplastic -- genetics KW - Ovarian Neoplasms -- metabolism KW - Ovarian Neoplasms -- genetics KW - Mesothelioma -- metabolism KW - Membrane Proteins -- metabolism KW - CA-125 Antigen -- metabolism KW - Neoplasm Proteins -- genetics KW - CA-125 Antigen -- genetics KW - Mesothelioma -- genetics KW - Membrane Proteins -- genetics KW - Neoplasm Proteins -- metabolism KW - Membrane Glycoproteins -- metabolism KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66871558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Protein+kinase+PKR+mutants+resistant+to+the+poxvirus+pseudosubstrate+K3L+protein.&rft.au=Seo%2C+Eun+Joo%3BLiu%2C+Furong%3BKawagishi-Kobayashi%2C+Makiko%3BUng%2C+Tekly+L%3BCao%2C+Chune%3BDar%2C+Arvin+C%3BSicheri%2C+Frank%3BDever%2C+Thomas+E&rft.aulast=Seo&rft.aufirst=Eun&rft.date=2008-11-04&rft.volume=105&rft.issue=44&rft.spage=16894&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0805524105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-06 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Jul 20;276(29):27371-5 [11369781] Tumour Biol. 2001 Nov-Dec;22(6):348-66 [11786729] Histopathology. 2002 Mar;40(3):237-44 [11895489] Tumour Biol. 2002 May-Jun;23(3):154-69 [12218296] Am J Surg Pathol. 2003 Feb;27(2):150-8 [12548160] Am J Surg Pathol. 2003 Nov;27(11):1418-28 [14576474] J Biol Chem. 2004 Mar 5;279(10):9190-8 [14676194] J Biol Chem. 2004 Mar 26;279(13):13174-82 [14764598] J Clin Invest. 1981 Nov;68(5):1331-7 [7028788] N Engl J Med. 1983 Oct 13;309(15):883-7 [6310399] Int J Cancer. 1992 Feb 1;50(3):373-81 [1735605] J Biol Chem. 1995 Sep 15;270(37):21984-90 [7665620] Protein Sci. 1995 Jul;4(7):1421-5 [7670383] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):136-40 [8552591] Histopathology. 1997 Jan;30(1):49-56 [9023557] J Biol Chem. 2005 Jan 7;280(1):607-17 [15491997] Clin Cancer Res. 2005 May 15;11(10):3814-20 [15897581] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):1014-20 [16702385] Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9637-42 [16763048] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1751 [16985043] Mol Cancer. 2006;5(1):50 [17067392] Cancer Lett. 2007 Mar 8;247(1):130-6 [16677756] Clin Cancer Res. 2007 Mar 1;13(5):1571-5 [17332303] Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4456-66 [17671130] Cancer Immun. 2007;7:20 [18088084] Eur J Cancer. 2008 Jan;44(1):46-53 [17945478] Gene. 2008 Mar 15;410(2):215-22 [18242885] Cancer J. 2008 Jan-Feb;14(1):7-9 [18303475] Curr Med Chem. 2008;15(9):855-67 [18473795] Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1520-6 [18559570] Curr Opin Pharmacol. 2008 Oct;8(5):616-9 [18602024] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M806776200 ER - TY - JOUR T1 - Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation. AN - 66871289; 19068482 AB - Activation of a number of class A G protein-coupled receptors (GPCRs) is thought to involve two molecular switches, a rotamer toggle switch within the transmembrane domain and an ionic lock at the cytoplasmic surface of the receptor; however, the mechanism by which agonist binding changes these molecular interactions is not understood. Importantly, 80% of GPCRs including free fatty acid receptor 1 (FFAR1) lack the complement of amino acid residues implicated in either or both of these two switches; the mechanism of activation of these GPCRs is therefore less clear. By homology modeling, we identified two Glu residues (Glu-145 and Glu-172) in the second extracellular loop of FFAR1 that form putative interactions individually with two transmembrane Arg residues (Arg-183(5.39) and Arg-258(7.35)) to create two ionic locks. Molecular dynamics simulations showed that binding of agonists to FFAR1 leads to breakage of these Glu-Arg interactions. In mutagenesis experiments, breakage of these two putative interactions by substituting Ala for Glu-145 and Glu-172 caused constitutive receptor activation. Our results therefore reveal a molecular switch for receptor activation present on the extracellular surface of FFAR1 that is broken by agonist binding. Similar ionic locks between the transmembrane domains and the extracellular loops may constitute a mechanism common to other class A GPCRs also. JF - The Journal of biological chemistry AU - Sum, Chi Shing AU - Tikhonova, Irina G AU - Costanzi, Stefano AU - Gershengorn, Marvin C AD - Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/02/06/ PY - 2009 DA - 2009 Feb 06 SP - 3529 EP - 3536 VL - 284 IS - 6 SN - 0021-9258, 0021-9258 KW - FFAR1 protein, human KW - 0 KW - Receptors, G-Protein-Coupled KW - Glutamic Acid KW - 3KX376GY7L KW - Arginine KW - 94ZLA3W45F KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Cricetulus KW - Humans KW - Protein Structure, Tertiary -- physiology KW - CHO Cells KW - Protein Structure, Secondary -- physiology KW - Cricetinae KW - Glutamic Acid -- metabolism KW - Arginine -- metabolism KW - Models, Molecular KW - Arginine -- genetics KW - Receptors, G-Protein-Coupled -- metabolism KW - Receptors, G-Protein-Coupled -- genetics KW - Glutamic Acid -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66871289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=A+SARS+DNA+vaccine+induces+neutralizing+antibody+and+cellular+immune+responses+in+healthy+adults+in+a+Phase+I+clinical+trial&rft.au=Martin%2C+Julie+E%3BLouder%2C+Mark+K%3BHolman%2C+LaSonji+A%3BGordon%2C+Ingelise+J%3BEnama%2C+Mary+E%3BLarkin%2C+Brenda+D%3BAndrews%2C+Charla+A%3BVogel%2C+Leatrice%3BKoup%2C+Richard+A%3BRoederer%2C+Mario%3BBailer%2C+Robert+T%3BGomez%2C+Phillip+L%3BNason%2C+Martha%3BMascola%2C+John+R%3BNabel%2C+Gary+J%3BGraham%2C+Barney+S&rft.aulast=Martin&rft.aufirst=Julie&rft.date=2008-11-01&rft.volume=26&rft.issue=50&rft.spage=6338&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.09.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-06 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 2008 Feb 14;51(3):625-33 [18193825] Pharmacol Ther. 2007 Dec;116(3):437-48 [17900700] Chem Biol. 2008 Apr;15(4):343-53 [18420141] J Med Chem. 2008 May 22;51(10):2907-14 [18442228] Curr Pharm Des. 2008;14(15):1525-52 [18537675] J Biol Chem. 2008 Jun 13;283(24):16269-73 [18385136] Diabetes. 2008 Aug;57(8):2211-9 [18477808] Science. 2000 Aug 4;289(5480):739-45 [10926528] J Biol Chem. 2001 Aug 3;276(31):29171-7 [11375997] J Biol Chem. 2002 Mar 29;277(13):11441-9 [11801601] Mol Pharmacol. 2002 May;61(5):1025-32 [11961120] J Biol Chem. 2002 Oct 25;277(43):40989-96 [12167654] J Comput Chem. 2003 Nov 15;24(14):1691-702 [12964188] Biophys J. 2003 Nov;85(5):2900-18 [14581194] J Med Chem. 2004 Oct 21;47(22):5393-404 [15481977] J Mol Biol. 1993 Dec 5;234(3):779-815 [8254673] J Biol Chem. 1994 Oct 7;269(40):24692-8 [7929142] Mol Pharmacol. 1996 Apr;49(4):683-91 [8609897] Biochemistry. 1997 Dec 16;36(50):15670-6 [9398295] Biophys J. 1998 Mar;74(3):1087-100 [9512011] Biotechniques. 1998 Aug;25(2):240-4 [9714883] Biochemistry. 1999 Mar 23;38(12):3498-507 [10090736] DNA Cell Biol. 2005 Jan;24(1):54-61 [15684720] Biochemistry. 2005 Feb 22;44(7):2419-31 [15709754] Nat Struct Mol Biol. 2005 Apr;12(4):320-6 [15768031] J Biol Chem. 2005 May 27;280(21):20253-60 [15774473] J Med Chem. 2005 Dec 29;48(26):8108-11 [16366591] Proteins. 2006 Feb 1;62(2):509-38 [16294340] Mol Pharmacol. 2006 Mar;69(3):680-90 [16293711] Bioorg Med Chem Lett. 2006 Apr 1;16(7):1840-5 [16439116] Br J Pharmacol. 2006 Jul;148(5):619-28 [16702987] J Biol Chem. 2007 Mar 9;282(10):7385-96 [17213190] Mol Pharmacol. 2007 Apr;71(4):959-64 [17192495] Mol Pharmacol. 2007 Apr;71(4):994-1005 [17200419] J Med Chem. 2007 Jun 14;50(12):2807-17 [17500511] J Biol Chem. 2007 Jun 15;282(24):17405-12 [17403667] J Med Chem. 2007 Jun 28;50(13):2981-9 [17552505] J Biol Chem. 2007 Aug 31;282(35):25677-86 [17591774] J Biol Chem. 2007 Oct 5;282(40):29248-55 [17699519] Science. 2007 Nov 23;318(5854):1266-73 [17962519] Science. 2007 Nov 23;318(5854):1258-65 [17962520] Nat Rev Drug Discov. 2008 Apr;7(4):339-57 [18382464] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M806987200 ER - TY - JOUR T1 - Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25. AN - 66889431; 18948574 AB - Adult T-cell leukemia (ATL) is caused by human T-cell lymphotropic virus I (HTLV-1) and is an aggressive malignancy of CD4, CD25-expressing leukemia, and lymphoma cells. There is no accepted curative therapy for ATL. Depsipeptide, a histone deacetylase inhibitor, has demonstrated major antitumor effects in leukemias and lymphomas. In this study, we investigated the therapeutic efficacy of depsipeptide alone and in combination with daclizumab (humanized anti-Tac) in a murine model of human ATL. The Met-1 ATL model was established by intraperitoneal injection of ex vivo leukemic cells into nonobese diabetic/severe combined immunodeficiency mice. Either depsipeptide, given at 0.5 mg/kg every other day for 2 weeks, or daclizumab, given at 100 microg weekly for 4 weeks, inhibited tumor growth as monitored by serum levels of soluble IL-2R-alpha (sIL-2R-alpha) and soluble beta2-microglobulin (beta2mu) (P < .001), and prolonged survival of the leukemia-bearing mice (P < .001) compared with the control group. Combination of depsipeptide with daclizumab enhanced the antitumor effect, as shown by both sIL-2R-alpha and beta2mu levels and survival of the leukemia-bearing mice, compared with those in the depsipeptide or daclizumab alone groups (P < .001). The significantly improved therapeutic efficacy by combining depsipeptide with daclizumab supports a clinical trial of this combination in the treatment of ATL. JF - Blood AU - Chen, Jing AU - Zhang, Meili AU - Ju, Wei AU - Waldmann, Thomas A AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2009/02/05/ PY - 2009 DA - 2009 Feb 05 SP - 1287 EP - 1293 VL - 113 IS - 6 KW - Annexin A5 KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Depsipeptides KW - Histones KW - Il2ra protein, mouse KW - Immunoglobulin G KW - Immunosuppressive Agents KW - Interleukin-2 Receptor alpha Subunit KW - Receptors, Interleukin-2 KW - daclizumab KW - CUJ2MVI71Y KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 9 KW - Abridged Index Medicus KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Mice, Inbred NOD KW - Mice KW - Annexin A5 -- metabolism KW - Receptors, Interleukin-2 -- immunology KW - Drug Therapy, Combination KW - Acetylation KW - Blotting, Western KW - Survival Rate KW - Caspase 9 -- metabolism KW - Histones -- metabolism KW - Apoptosis -- drug effects KW - Mice, SCID KW - Maximum Tolerated Dose KW - Drug Evaluation, Preclinical KW - Caspase 3 -- metabolism KW - Interleukin-2 Receptor alpha Subunit -- metabolism KW - Leukemia-Lymphoma, Adult T-Cell -- pathology KW - Leukemia-Lymphoma, Adult T-Cell -- immunology KW - Disease Models, Animal KW - Interleukin-2 Receptor alpha Subunit -- immunology KW - Depsipeptides -- therapeutic use KW - Leukemia-Lymphoma, Adult T-Cell -- drug therapy KW - Immunosuppressive Agents -- therapeutic use KW - Immunoglobulin G -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66889431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Enhancement+of+immunostimulatory+properties+of+exosomal+vaccines+by+incorporation+of+fusion-competent+G+protein+of+vesicular+stomatitis+virus&rft.au=Temchura%2C+Vladimir+V%3BTenbusch%2C+Matthias%3BNchinda%2C+Godwin%3BNabi%2C+Ghulam%3BTippler%2C+Bettina%3BZelenyuk%2C+Maryna%3BWildner%2C+Oliver%3BUberla%2C+Klaus%3BKuate%2C+Seraphin&rft.aulast=Temchura&rft.aufirst=Vladimir&rft.date=2008-11-01&rft.volume=26&rft.issue=48&rft.spage=3662&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.04.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-26 N1 - Date created - 2009-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Aug 2;92(15):1210-6 [10922406] Mol Cancer Res. 2007 Oct;5(10):981-9 [17951399] Jpn J Cancer Res. 2000 Nov;91(11):1154-60 [11092981] Cancer Res. 2000 Dec 15;60(24):6977-84 [11156399] Jpn J Cancer Res. 2001 May;92(5):529-36 [11376562] Leuk Lymphoma. 2001 Jan;40(3-4):287-94 [11426550] Blood. 2001 Nov 1;98(9):2865-8 [11675364] Cancer Res. 2002 Feb 15;62(4):1083-6 [11861386] Clin Cancer Res. 2002 Mar;8(3):718-28 [11895901] Blood. 2002 Jul 1;100(1):208-16 [12070029] Oncogene. 2002 Oct 17;21(47):7241-6 [12370815] J Exp Ther Oncol. 2002 Nov-Dec;2(6):325-32 [12440223] J Thorac Cardiovasc Surg. 2003 May;125(5):1132-42 [12771887] J Virol. 2004 May;78(9):4582-90 [15078940] Blood. 2004 Jun 15;103(12):4636-43 [14996704] J Virol. 2004 Jul;78(13):6735-43 [15194748] Cancer Res. 2004 Aug 15;64(16):5825-9 [15313926] Adv Cancer Res. 2004;91:137-68 [15327890] J Immunol. 1981 Apr;126(4):1393-7 [6970774] Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9 [6261256] Proc Natl Acad Sci U S A. 1981 Oct;78(10):6476-80 [7031654] Proc Natl Acad Sci U S A. 1982 Mar;79(6):2031-5 [6979048] J Clin Invest. 1984 Jun;73(6):1711-8 [6327770] J Clin Invest. 1985 Aug;76(2):446-53 [2993359] Proc Natl Acad Sci U S A. 1989 Dec;86(24):10029-33 [2513570] Br J Haematol. 1991 Nov;79(3):428-37 [1751370] Blood. 1993 Sep 15;82(6):1701-12 [8400227] Blood. 1994 Sep 1;84(5):1415-20 [8068938] N Engl J Med. 1995 Jun 29;332(26):1744-8 [7760890] N Engl J Med. 1995 Jun 29;332(26):1749-51 [7760891] J Exp Med. 1995 Nov 1;182(5):1545-56 [7595224] Invest New Drugs. 1997;15(3):195-206 [9387042] Oncogene. 1998 Sep 24;17(12):1503-8 [9794227] J Chromatogr B Biomed Sci Appl. 1998 Nov 20;719(1-2):169-76 [9869377] Blood. 1999 Aug 15;94(4):1401-8 [10438728] Blood. 2005 Feb 1;105(3):1231-6 [15383455] J Immunol. 2005 May 1;174(9):5187-91 [15843513] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5941-6 [16585503] Clin Cancer Res. 2006 Jun 15;12(12):3762-73 [16778104] Blood. 2006 Aug 1;108(3):1021-9 [16569765] Cancer J. 2007 Mar-Apr;13(2):80-3 [17476134] Br J Cancer. 2000 Sep;83(6):817-25 [10952788] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-04-149658 ER - TY - JOUR T1 - alpha-Synuclein and neuronal cell death. AN - 733919675; 19193223 AB - alpha-Synuclein is a small protein that has special relevance for understanding Parkinson disease and related disorders. Not only is alpha-synuclein found in Lewy bodies characteristic of Parkinson disease, but also mutations in the gene for alpha-synuclein can cause an inherited form of Parkinson disease and expression of normal alpha-synuclein can increase the risk of developing Parkinson disease in sporadic, or non-familial, cases. Both sporadic and familial Parkinson disease are characterized by substantial loss of several groups of neurons, including the dopaminergic cells of the substantia nigra that are the target of most current symptomatic therapies. Therefore, it is predicted that alpha-synuclein, especially in its mutant forms or under conditions where its expression levels are increased, is a toxic protein in the sense that it is associated with an increased rate of neuronal cell death. This review will discuss the experimental contexts in which alpha-synuclein has been demonstrated to be toxic. I will also outline what is known about the mechanisms by which alpha-synuclein triggers neuronal damage, and identify some of the current gaps in our knowledge about this subject. Finally, the therapeutic implications of toxicity of alpha-synuclein will be discussed. JF - Molecular neurodegeneration AU - Cookson, Mark R AD - Laboratory of Neurogenetics, National Institute on Aging, NIH, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20982-3707, USA. cookson@mail.nih.gov. Y1 - 2009/02/04/ PY - 2009 DA - 2009 Feb 04 SP - 9 VL - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733919675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+neurodegeneration&rft.atitle=alpha-Synuclein+and+neuronal+cell+death.&rft.au=Cookson%2C+Mark+R&rft.aulast=Cookson&rft.aufirst=Mark&rft.date=2009-02-04&rft.volume=4&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Molecular+neurodegeneration&rft.issn=1750-1326&rft_id=info:doi/10.1186%2F1750-1326-4-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-10-02 N1 - Date created - 2009-02-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 2004 Mar 16;43(10):2871-8 [15005622] Ann Neurol. 2004 Feb;55(2):164-73 [14755719] Science. 2003 Dec 5;302(5651):1772-5 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J Neurosci Res. 2001 Sep 1;65(5):432-8 [11536327] Neurobiol Dis. 2001 Jun;8(3):535-9 [11442360] Hum Mol Genet. 2001 Apr 15;10(9):919-26 [11309365] Exp Neurol. 2000 Dec;166(2):324-33 [11085897] J Biol Chem. 2000 Nov 3;275(44):34328-34 [10915790] Science. 2000 Nov 3;290(5493):985-9 [11062131] Neurosci Lett. 2000 Oct 6;292(2):128-30 [10998565] Eur J Neurosci. 2000 Aug;12(8):3073-7 [10971650] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1750-1326-4-9 ER - TY - JOUR T1 - Reaction mechanism of the epsilon subunit of E. coli DNA polymerase III: insights into active site metal coordination and catalytically significant residues. AN - 66857135; 19119875 AB - The 28 kDa epsilon subunit of Escherichia coli DNA polymerase III is the exonucleotidic proofreader responsible for editing polymerase insertion errors. Here, we study the mechanism by which epsilon carries out the exonuclease activity. We performed quantum mechanics/molecular mechanics calculations on the N-terminal domain containing the exonuclease activity. Both the free-epsilon and a complex epsilon bound to a theta homologue (HOT) were studied. For the epsilon-HOT complex Mg(2+) or Mn(2+) were investigated as the essential divalent metal cofactors, while only Mg(2+) was used for free-epsilon. In all calculations a water molecule bound to the catalytic metal acts as the nucleophile for hydrolysis of the phosphate bond. Initially, a direct proton transfer to H162 is observed. Subsequently, the nucleophilic attack takes place followed by a second proton transfer to E14. Our results show that the reaction catalyzed with Mn(2+) is faster than that with Mg(2+), in agreement with experiment. In addition, the epsilon-HOT complex shows a slightly lower energy barrier compared to free-epsilon. In all cases the catalytic metal is observed to be pentacoordinated. Charge and frontier orbital analyses suggest that charge transfer may stabilize the pentacoordination. Energy decomposition analysis to study the contribution of each residue to catalysis suggests that there are several important residues. Among these, H98, D103, D129, and D146 have been implicated in catalysis by mutagenesis studies. Some of these residues were found to be structurally conserved on human TREX1, the exonuclease domains from E. coli DNA-Pol I, and the DNA polymerase of bacteriophage RB69. JF - Journal of the American Chemical Society AU - Cisneros, G Andrés AU - Perera, Lalith AU - Schaaper, Roel M AU - Pedersen, Lars C AU - London, Robert E AU - Pedersen, Lee G AU - Darden, Thomas A AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. cisnero1@niehs.nih.gov Y1 - 2009/02/04/ PY - 2009 DA - 2009 Feb 04 SP - 1550 EP - 1556 VL - 131 IS - 4 KW - Metals KW - 0 KW - Protein Subunits KW - DNA Polymerase III KW - EC 2.7.7.- KW - Index Medicus KW - Protein Subunits -- genetics KW - Computer Simulation KW - Models, Molecular KW - Catalytic Domain KW - Crystallography, X-Ray KW - Protein Subunits -- metabolism KW - Protein Structure, Tertiary KW - Protein Subunits -- chemistry KW - DNA Polymerase III -- chemistry KW - DNA Polymerase III -- genetics KW - Metals -- chemistry KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - Metals -- metabolism KW - DNA Polymerase III -- metabolism KW - Biocatalysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66857135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Reaction+mechanism+of+the+epsilon+subunit+of+E.+coli+DNA+polymerase+III%3A+insights+into+active+site+metal+coordination+and+catalytically+significant+residues.&rft.au=Cisneros%2C+G+Andr%C3%A9s%3BPerera%2C+Lalith%3BSchaaper%2C+Roel+M%3BPedersen%2C+Lars+C%3BLondon%2C+Robert+E%3BPedersen%2C+Lee+G%3BDarden%2C+Thomas+A&rft.aulast=Cisneros&rft.aufirst=G&rft.date=2009-02-04&rft.volume=131&rft.issue=4&rft.spage=1550&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=1520-5126&rft_id=info:doi/10.1021%2Fja8082818 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-30 N1 - Date created - 2009-01-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 1999 Oct 15;99(2):155-66 [10535734] Biochemistry. 1999 Nov 30;38(48):16001-9 [10625468] Acc Chem Res. 2001 Jan;34(1):72-9 [11170358] Nucleic Acids Res. 2001 Mar 1;29(5):1017-26 [11222749] Biochemistry. 2002 Jan 8;41(1):94-110 [11772007] Structure. 2002 Apr;10(4):535-46 [11937058] Biochemistry. 2002 Apr 23;41(16):5266-75 [11955076] Biometals. 2002 Sep;15(3):225-35 [12206389] Chembiochem. 2002 Dec 2;3(12):1242-50 [12465033] J Comput Chem. 2003 Sep;24(12):1514-27 [12868114] J Am Chem Soc. 2003 Aug 27;125(34):10384-93 [12926963] Proteins. 2004 Feb 1;54(2):222-30 [14696184] J Bacteriol. 2004 May;186(9):2774-80 [15090519] J Biol Chem. 2004 Apr 23;279(17):16895-8 [14988392] J Chem Phys. 2004 Jul 8;121(2):697-706 [15260596] J Chem Phys. 2004 May 1;120(17):8039-52 [15267723] J Mol Biol. 1976 May 15;103(2):227-49 [985660] Nature. 1977 Jun 16;267(5612):585-90 [301613] Cell. 1989 Oct 6;59(1):219-28 [2790959] EMBO J. 1991 Jan;10(1):25-33 [1989886] J Biol Chem. 1991 Apr 25;266(12):7888-92 [1850425] J Biol Chem. 1991 Oct 15;266(29):19127-30 [1918028] J Biol Chem. 1993 Nov 15;268(32):23762-5 [8226906] Methods Enzymol. 1995;262:363-85 [8594362] Biochemistry. 1996 Oct 1;35(39):12919-25 [8841137] Nucleic Acids Res. 1997 Dec 15;25(24):5110-8 [9396823] Nucleic Acids Res. 1998 Sep 1;26(17):4005-11 [9705512] J Bacteriol. 1998 Nov;180(21):5712-7 [9791123] Biochemistry. 1999 Jan 12;38(2):696-704 [9888810] Biochem J. 2004 Dec 1;384(Pt 2):337-48 [15352874] J Am Chem Soc. 2005 Mar 23;127(11):4010-20 [15771538] J Chem Phys. 2005 Mar 15;122(11):114502 [15836224] J Bacteriol. 2005 Aug;187(16):5528-36 [16077097] J Comput Chem. 2005 Dec;26(16):1668-88 [16200636] J Chem Phys. 2006 Feb 7;124(5):054109 [16468853] Mol Cell. 2006 Apr 7;22(1):5-13 [16600865] EMBO J. 2006 May 3;25(9):1924-33 [16601679] Nucleic Acids Res. 2006;34(9):2528-35 [16687658] J Bacteriol. 2006 Aug;188(16):5831-8 [16885451] Chem Rev. 2006 Aug;106(8):3210-35 [16895325] J Mol Biol. 2006 Oct 6;362(5):1159-80 [16949606] J Mol Biol. 2006 Oct 20;363(2):506-19 [16963082] J Biol Chem. 2006 Dec 15;281(50):38466-71 [16973612] Am J Hum Genet. 2007 Apr;80(4):811-5 [17357087] Mol Cell. 2007 Mar 23;25(6):851-62 [17386262] J Biol Chem. 2007 Apr 6;282(14):10537-43 [17293595] J Am Chem Soc. 2007 Apr 18;129(15):4731-7 [17375926] J Mol Med (Berl). 2007 May;85(5):531-7 [17440703] Structure. 2007 Oct;15(10):1272-84 [17937916] Annu Rev Phys Chem. 2008;59:573-601 [18393679] J Am Chem Soc. 2008 Aug 20;130(33):10955-62 [18662000] DNA Repair (Amst). 2008 Nov 1;7(11):1824-34 [18692600] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ja8082818 ER - TY - JOUR T1 - Human Papillomavirus Type 18 DNA Load and 2-Year Cumulative Diagnoses of Cervical Intraepithelial Neoplasia Grades 2-3 AN - 20457090; 9146003 AB - Background The clinical relevance of the amount of human papillomavirus type 18 (HPV18) DNA in cervical tissue (ie, HPV18 DNA load) is unknown.Methods Study subjects were 303 women who were HPV18 positive at enrollment into the Atypical Squamous Cells of Undetermined Significance (ASC-US) and Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study. HPV18 DNA load, expressed as copies of HPV18 per nanogram of cellular DNA, at enrollment was quantitatively measured. Subjects were followed up semiannually for a period of 2 years for detection of cervical intraepithelial neoplasia 2-3 (CIN2-3). A linear regression model was used to examine associations of CIN2-3 with HPV18 DNA load. All statistical tests were two-sided.Results CIN2-3 was confirmed in 92 of 303 (30.4%) HPV18-positive women. Among women without CIN2-3, HPV18 DNA load was positively associated with increasing severity of cervical cytology at enrollment (Ptrend < .001). However, among those with CIN2-3, HPV18 DNA load was not associated with severity of cervical cytology at enrollment (Ptrend = .33). The ratios of geometric means of HPV18 DNA load at enrollment among women with CIN2-3, relative to those without, were 6.06 (95% confidence interval [CI] = 0.31 to 117.92) for those with normal cytology at enrollment, 0.50 (95% CI = 0.10 to 2.44) for those with ASC-US, 0.11 (95% CI = 0.03 to 0.46) for those with LSIL, and 0.07 (95% CI = 0.01 to 0.80) for those with high-grade squamous intraepithelial lesion (HSIL). After adjusting for age and coinfection with other high-risk HPVs, a statistically significant association of lower HPV18 DNA load with CIN2-3 was observed among women with LSIL or HSIL at enrollment (P = .02). Within the 2-year period, HPV18 DNA load was unrelated to the timing of CIN2-3 diagnosis. Overall results were similar when the outcome was CIN3.Conclusions HPV18 DNA load was higher for women with LSIL or HSIL at enrollment with no evidence of CIN2-3 during the 2-year follow-up period than it was for women with CIN2-3. Thus, testing for high levels of HPV18 DNA does not appear to be clinically useful. JF - Journal of the National Cancer Institute AU - Xi, Long Fu AU - Koutsky, Laura A AU - Castle, Philip E AU - Wheeler, Cosette M AU - Galloway, Denise A AU - Mao, Constance AU - Ho, Jesse AU - Kiviat, Nancy B AD - Affiliations of authors: Department of Pathology (LFX, JH, NBK) and Department of Obstetrics and Gynecology (CM), School of Medicine, Department of Epidemiology (LFX, LAK), School of Public Health and Community Medicine, University of Washington, Seattle, WA; Division of Cancer Epidemiology and Genetics (PEC), National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Microbiology and Department of Molecular Genetics, School of Medicine, University of New Mexico, Albuquerque, NM (CMW); Fred Hutchinson Cancer Research Center, Seattle, WA (DAG), longfu@u.washington.edu Y1 - 2009/02/04/ PY - 2009 DA - 2009 Feb 04 SP - 153 EP - 161 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 3 SN - 0027-8874, 0027-8874 KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Risk Abstracts KW - Age KW - Squamous cells KW - Statistical analysis KW - Human papillomavirus 18 KW - Cancer KW - Neoplasia KW - DNA KW - Regression analysis KW - Lesions KW - Risk groups KW - Cervix KW - Human papillomavirus KW - N 14845:Miscellaneous KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20457090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Human+Papillomavirus+Type+18+DNA+Load+and+2-Year+Cumulative+Diagnoses+of+Cervical+Intraepithelial+Neoplasia+Grades+2-3&rft.au=Xi%2C+Long+Fu%3BKoutsky%2C+Laura+A%3BCastle%2C+Philip+E%3BWheeler%2C+Cosette+M%3BGalloway%2C+Denise+A%3BMao%2C+Constance%3BHo%2C+Jesse%3BKiviat%2C+Nancy+B&rft.aulast=Xi&rft.aufirst=Long&rft.date=2009-02-04&rft.volume=101&rft.issue=3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn461 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Squamous cells; Regression analysis; Statistical analysis; DNA; Risk groups; Cervix; Neoplasia; Lesions; Cancer; Human papillomavirus 18; Human papillomavirus DO - http://dx.doi.org/10.1093/jnci/djn461 ER - TY - JOUR T1 - Estimated Risk of Radiation-Induced Breast Cancer From Mammographic Screening for Young BRCA Mutation Carriers AN - 20455443; 9146008 AB - BRCA mutation carriers are recommended to start mammographic screening for breast cancer as early as age 25-30 years. We used an excess relative risk model (based on a pooled analysis of three cohorts with 7600 subjects who received radiation exposure) to estimate the lifetime risk of radiation-induced breast cancer from five annual mammographic screenings in young (<40 years) BRCA mutation carriers. We then estimated the reduction in breast cancer mortality required to outweigh the radiation risk. Breast cancer rates for mutation carriers were based on a pooled analysis of 22 pedigree studies with 8139 subjects. For BRCA1 mutation carriers, the estimated lifetime risk of radiation-induced breast cancer mortality per 10000 women resulting from annual mammography was 26 (95% confidence interval [CI] = 14 to 49) for screening at age 25-29 years, 20 (95% CI = 11 to 39) for screening at age 30-34 years, and 13 (95% CI = 7 to 23) for screening at age 35-39 years. To outweigh these risks, screening would have to reduce breast cancer mortality by 51% (95% CI = 27% to 96%) at age 25-29 years, by 12% (95% CI = 6% to 23%) at age 30-34 years, and by 4% (95% CI = 2% to 7%) at age 35-39 years; estimates were similar for BRCA2 mutation carriers. If we assume that the mortality reduction from mammography is 15%-25% or less for young women, these results suggest that there would be no net benefit from annual mammographic screening of BRCA mutation carriers at age 25-29 years; the net benefit would be zero or small at age 30-34 years, but there should be some net benefit at age 35 or older. These results depend on a number of assumptions due to the absence of empiric data. The impact of varying these assumptions was therefore examined. JF - Journal of the National Cancer Institute AU - Berrington de Gonzalez, Amy AU - Berg, Christine D AU - Visvanathan, Kala AU - Robson, Mark AD - Affiliations of authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (ABdG, KV); Early Detection Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD (CDB); Clinical Genetics and Breast Cancer Medicine Services, Memorial Sloan-Kettering Cancer Center, New York, NY (MR), aberring@jhsph.edu Y1 - 2009/02/04/ PY - 2009 DA - 2009 Feb 04 SP - 205 EP - 209 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 101 IS - 3 SN - 0027-8874, 0027-8874 KW - Genetics Abstracts; Risk Abstracts KW - Pedigree KW - Risk assessment KW - Mortality KW - Age KW - Data processing KW - Mammography KW - BRCA2 protein KW - Cancer KW - Models KW - Radiation KW - Geriatrics KW - BRCA1 protein KW - Breast cancer KW - Mutation KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20455443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Estimated+Risk+of+Radiation-Induced+Breast+Cancer+From+Mammographic+Screening+for+Young+BRCA+Mutation+Carriers&rft.au=Berrington+de+Gonzalez%2C+Amy%3BBerg%2C+Christine+D%3BVisvanathan%2C+Kala%3BRobson%2C+Mark&rft.aulast=Berrington+de+Gonzalez&rft.aufirst=Amy&rft.date=2009-02-04&rft.volume=101&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn440 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Pedigree; Mortality; Age; Mammography; Data processing; BRCA2 protein; Models; Radiation; Geriatrics; Breast cancer; BRCA1 protein; Mutation; Cancer DO - http://dx.doi.org/10.1093/jnci/djn440 ER - TY - JOUR T1 - Disparities in Reported Reasons for Not Initiating or Stopping Antiretroviral Treatment Among a Diverse Sample of Persons Living with HIV AN - 875688046; 19015925 AB - Disparities in the use of antiretroviral therapy (ART) for HIV disease have been documented across race, gender, and substance use groups. The current analysis compares self-reported reasons for never taking or stopping ART among a diverse sample of men and women living with HIV. Cross-sectional interview. HIV + (N=3,818) adults, 968 of whom reported discontinuing or never using ART. Computerized self-administered and interviewer-administered self-reported demographic and treatment variables, including gender, race, ethnicity, CD4 count, detectable viral load, and reported reasons for not taking antiretroviral therapy. Despite equivalent use of ART in the current sample, African-American respondents were 1.7 times more likely to report wanting to hide their HIV status and 1.7 times more likely to report a change in doctors/clinics as reasons for stopping ART (p=.049, and p=.042) and had odds 4.5 times those of non-African Americans of reporting waiting for viral marker counts to worsen (p=< .0001). There was a lower tendency (OR=0.4) for women to endorse concerns of keeping their HIV status hidden as a reason for stopping ART compared to men (p=.003). Although those with an IDU history were less likely to be on ART, no differences in reasons for stopping or never initiating ART were found between those with and without an IDU history. A desire to conceal HIV status as well as a change in doctors/clinics as reasons for discontinuing ART were considerably more common among African Americans, suggesting that perceived HIV/AIDS stigma is an obstacle to maintenance of treatment. Findings also indicate differences in reasons for stopping ART by gender and a perceived desire to wait for counts to worsen as a reason for not taking ART by African Americans, regardless of detectable viral load, CD4 count, age, education, employment, sexual orientation, and site.[PUBLICATION ABSTRACT] JF - Journal of General Internal Medicine AU - Johnson, Mallory O AU - Chesney, Margaret A AU - Neilands, Torsten B AU - Dilworth, Samantha E AU - Remien, Robert H AU - Weinhardt, Lance S AU - Wong, F Lennie AU - Morin, Stephen F Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 247 EP - 51 CY - New York PB - Springer Science & Business Media VL - 24 IS - 2 SN - 08848734 KW - Medical Sciences KW - Anti-Retroviral Agents KW - Antiretroviral drugs KW - Drug therapy KW - Acquired immune deficiency syndrome--AIDS KW - Human immunodeficiency virus--HIV KW - Health behavior KW - Socioeconomic Factors KW - Cross-Sectional Studies KW - Sex Factors KW - Interviews as Topic -- methods KW - Viral Load -- methods KW - Humans KW - Adult KW - Middle Aged KW - HIV Infections -- epidemiology KW - Male KW - Female KW - Healthcare Disparities -- methods KW - Patient Compliance -- psychology KW - HIV Infections -- drug therapy KW - Patient Acceptance of Health Care -- psychology KW - HIV Infections -- psychology KW - Anti-Retroviral Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875688046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+General+Internal+Medicine&rft.atitle=Disparities+in+Reported+Reasons+for+Not+Initiating+or+Stopping+Antiretroviral+Treatment+Among+a+Diverse+Sample+of+Persons+Living+with+HIV&rft.au=Johnson%2C+Mallory+O%3BChesney%2C+Margaret+A%3BNeilands%2C+Torsten+B%3BDilworth%2C+Samantha+E%3BRemien%2C+Robert+H%3BWeinhardt%2C+Lance+S%3BWong%2C+F+Lennie%3BMorin%2C+Stephen+F&rft.aulast=Johnson&rft.aufirst=Mallory&rft.date=2009-02-01&rft.volume=24&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Journal+of+General+Internal+Medicine&rft.issn=08848734&rft_id=info:doi/10.1007%2Fs11606-008-0854-z LA - English DB - ProQuest Central N1 - Copyright - Society of General Internal Medicine 2009 N1 - Document feature - References N1 - Last updated - 2014-08-30 DO - http://dx.doi.org/10.1007/s11606-008-0854-z ER - TY - JOUR T1 - Why should addiction medicine be an attractive field for young physicians? AN - 839136514; 3828637 AB - The clinical practice and science of addiction are increasingly active fields, which are attracting professionals from diverse disciplines such as psychology and neurobiology. Our scientific knowledge of the pathophysiology of addiction is rapidly growing, along with the variety of effective treatments available to clinicians. Yet, we believe that the medical specialties of addiction medicine/psychiatry are not attracting the interest and enthusiasm of young physicians. What can be done? Methods We offer the opinions of two experience addiction psychiatrists. Results In the US, there has been a decline in the number of psychiatrists seeking training or board certification in addiction psychiatry; about one-third of graduates with such training are not practicing in an addiction psychiatry setting. There is wide-spread neglect of addiction medicine/psychiatry among the medical profession, academia and national health authorities. This neglect is unfortunate, given the enormous societal costs of addiction (3-5% of the gross domestic product in some developed countries), the substantial unmet need for addiction treatment, and the highly favourable benefit to cost yield (at least 7:1) from treatment. Conclusions We believe that addiction medicine/psychiatry can be made more attractive for young physicians. Helpful steps include widening acceptance as a medical specialty or subspecialty reducing the social stigma against people with substance use disorders, expanding insurance coverage and increasing the low rates of reimbursement for physicians. These steps would be easier to take with broader societal (and political) recognition of substance use disorders as a major cause of premature death, morbidity and economic burden. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Soyka, Michael AU - Gorelick, David A AD - Ludwig-Maximilians-Universität München ; National Institute on Drug Abuse Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 169 EP - 172 VL - 104 IS - 2 SN - 0965-2140, 0965-2140 KW - Sociology KW - Training KW - Psychology KW - Social problems KW - Medicine KW - Medical treatment KW - Health KW - Gross domestic product KW - Addiction KW - Stigma KW - Life styles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839136514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Why+should+addiction+medicine+be+an+attractive+field+for+young+physicians%3F&rft.au=Soyka%2C+Michael%3BGorelick%2C+David+A&rft.aulast=Soyka&rft.aufirst=Michael&rft.date=2009-02-01&rft.volume=104&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2008.02330.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5772; 561 6220; 7890 5792 10484; 12258 11762 11859 11856; 10404; 12894; 7894; 5627 8503 10242 3872 554 971; 7404; 11893 11979 DO - http://dx.doi.org/10.1111/j.1360-0443.2008.02330.x ER - TY - JOUR T1 - Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula AN - 754884430; 13443682 AB - In the United States, about 25% of infant formula sold is based on soy protein, which is an important source of estrogenic isoflavones in the human food supply. Nevertheless, few studies report isoflavone levels in infants. We did a partly cross-sectional and partly longitudinal pilot study to examine children's exposure to isoflavones from different feeding methods. A total of 166 full-term infants between birth and 1 year of age were recruited into soy formula, cow milk formula, or breast milk regimens according to their feeding histories. A total of 381 urine, 361 saliva, and 88 blood samples were collected at 382 visits. We used automated online solid-phase extraction coupled to high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for measuring three isoflavones (daidzein, genistein, and equol) in urine, and used similar LC/MS/MS techniques for saliva and blood spots. Concentrations of daidzein and genistein were undetectable in most blood or saliva samples from children fed breast milk or cow milk formula. The proportion of non-detectable values was somewhat lower in urine than in the other matrices. Concentrations of equol were detectable only in a few urine samples. For both daidzein and genistein, urine contained the highest median concentrations, followed by blood and then saliva. Urinary concentrations of genistein and daidzein were about 500 times higher in the soy formula-fed infants than in the cow milk formula-fed infants. The correlations between matrices for either analyte were strikingly lower than the correlation between the two analytes in any single matrix. We did not find significant correlations between isoflavone concentrations and the levels of certain hormones in children fed soy formula. Our results, based on much larger numbers of infants, strongly confirm previous reports, but whether phytoestrogens in soy formula are biologically active in infants is still an open question. We plan further longitudinal studies focusing on physical and developmental findings reflecting the effects of estrogen exposure.Journal of Exposure Science and Environmental Epidemiology (2009) 19, 223-234; doi:10.1038/jes.2008.44; published online 30 July 2008 JF - Journal of Exposure Science and Environmental Epidemiology AU - Cao, Yang AU - Calafat, Antonia M AU - Doerge, Daniel R AU - Umbach, David M AU - Bernbaum, Judy C AU - Twaddle, Nathan C AU - Ye, Xiaoyun AU - Rogan, Walter J AD - aEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 223 EP - 234 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 19 IS - 2 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts KW - infant formulas KW - Infant formulas KW - Age KW - Food KW - feeding KW - Breast milk KW - Hormones KW - Isoflavones KW - Mass spectroscopy KW - Cow's milk KW - Phytoestrogens KW - Feeding KW - Estrogens KW - Milk KW - Food supply KW - Data processing KW - Children KW - estrogenic activity KW - breast milk KW - daidzein KW - Soybeans KW - Birth KW - USA KW - Epidemiology KW - Urine KW - Saliva KW - Internet KW - Genistein KW - estrogens KW - Infants KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754884430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Isoflavones+in+urine%2C+saliva%2C+and+blood+of+infants%3A+data+from+a+pilot+study+on+the+estrogenic+activity+of+soy+formula&rft.au=Cao%2C+Yang%3BCalafat%2C+Antonia+M%3BDoerge%2C+Daniel+R%3BUmbach%2C+David+M%3BBernbaum%2C+Judy+C%3BTwaddle%2C+Nathan+C%3BYe%2C+Xiaoyun%3BRogan%2C+Walter+J&rft.aulast=Cao&rft.aufirst=Yang&rft.date=2009-02-01&rft.volume=19&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2008.44 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Feeding; Age; Estrogens; Infant formulas; Data processing; Food; Breast milk; Children; estrogenic activity; Hormones; Mass spectroscopy; Isoflavones; Soybeans; daidzein; Birth; Cow's milk; Epidemiology; Urine; Phytoestrogens; Saliva; Genistein; Internet; Infants; infant formulas; Food supply; Milk; feeding; breast milk; estrogens; USA DO - http://dx.doi.org/10.1038/jes.2008.44 ER - TY - JOUR T1 - Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human oral fluid AN - 753634046; 13324251 AB - Abstract not available. JF - Analytical and Bioanalytical Chemistry AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard Suite 200, Room 05A-721, Baltimore, MD 21224, USA, shakleyad@intra.nida.nih.gov PY - 2009 SP - 2349 EP - 2357 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 395 IS - 7 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Mass Spectrometry KW - Optimization KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753634046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Optimization+and+validation+of+a+liquid+chromatography-tandem+mass+spectrometry+method+for+the+simultaneous+quantification+of+nicotine%2C+cotinine%2C+trans-3%27-hydroxycotinine+and+norcotinine+in+human+oral+fluid&rft.au=Shakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Shakleya&rft.aufirst=Diaa&rft.date=2009-02-01&rft.volume=395&rft.issue=7&rft.spage=2349&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-009-3157-2 L2 - http://www.springerlink.com/content/y7un7r0400213623/?p=c638ad68437b42059aeb8b9973d64af4&pi=44 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Mass Spectrometry; Optimization DO - http://dx.doi.org/10.1007/s00216-009-3157-2 ER - TY - JOUR T1 - Widespread auditory deficits in tune deafness. AN - 742778922; pmid-19125028 AB - OBJECTIVE: The goal of this study was to investigate auditory function in individuals with deficits in musical pitch perception. We hypothesized that such individuals have deficits in nonspeech areas of auditory processing. DESIGN: We screened 865 randomly selected individuals to identify those who scored poorly on the Distorted Tunes test (DTT), a measure of musical pitch recognition ability. Those who scored poorly were given a comprehensive audiologic examination, and those with hearing loss or other confounding audiologic factors were excluded from further testing. Thirty-five individuals with tune deafness constituted the experimental group. Thirty-four individuals with normal hearing and normal DTT scores, matched for age, gender, handedness, and education, and without overt or reported psychiatric disorders made up the normal control group. Individual and group performance for pure-tone frequency discrimination at 1000 Hz was determined by measuring the difference limen for frequency (DLF). Auditory processing abilities were assessed using tests of pitch pattern recognition, duration pattern recognition, and auditory gap detection. In addition, we evaluated both attention and short- and long-term memory as variables that might influence performance on our experimental measures. Differences between groups were evaluated statistically using Wilcoxon nonparametric tests and t-tests as appropriate. RESULTS: The DLF at 1000 Hz in the group with tune deafness was significantly larger than that of the normal control group. However, approximately one-third of participants with tune deafness had DLFs within the range of performance observed in the control group. Many individuals with tune deafness also displayed a high degree of variability in their intertrial frequency discrimination performance that could not be explained by deficits in memory or attention. Pitch and duration pattern discrimination and auditory gap-detection ability were significantly poorer in the group with tune deafness than the normal control group. Approximately one-third of our participants with tune deafness displayed evidence of attention deficit with hyperactivity disorder on the Test of Variables of Attention. Test of Variables of Attention scores were significantly correlated with gap-detection scores, but not significantly correlated with any of the other experimental measures, including the DTT, DLF, and auditory pattern discrimination tests. Short- and long-term memory was not significantly related to any of the experimental measures. CONCLUSIONS: Individuals with tune deafness identified by the DTT have poor performance on many tests of auditory function. These include pure-tone frequency discrimination, pitch and duration pattern discrimination, and temporal resolution. Overall, reduction in performance does not seem to derive from deficits in memory or attention. However, because of the prevalence of attention deficit with hyperactivity disorder in those with tune deafness, this variable should be considered as a potentially confounding factor in future studies of tune deafness and its characteristics. Pure-tone frequency discrimination varied widely in individuals with tune deafness, and the high degree of intertrial variability suggests that frequency discrimination may be unstable in tune-deaf individuals. JF - Ear and hearing AU - Jones, Jennifer L AU - Zalewski, Christopher AU - Brewer, Carmen AU - Lucker, Jay AU - Drayna, Dennis AD - National Institute on Deafness and Other Communication Disorders/NIH, Bethesda, Maryland, USA. Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 63 EP - 72 VL - 30 IS - 1 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Memory, Short-Term KW - Humans KW - Adult KW - Pitch Discrimination KW - Time Perception KW - Attention KW - Male KW - Female KW - Psychological Tests KW - Pattern Recognition, Physiological KW - Auditory Perception KW - Auditory Perceptual Disorders -- physiopathology KW - Discrimination (Psychology) KW - Music KW - Hearing KW - Auditory Perceptual Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742778922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=Widespread+auditory+deficits+in+tune+deafness.&rft.au=Jones%2C+Jennifer+L%3BZalewski%2C+Christopher%3BBrewer%2C+Carmen%3BLucker%2C+Jay%3BDrayna%2C+Dennis&rft.aulast=Jones&rft.aufirst=Jennifer&rft.date=2009-02-01&rft.volume=30&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Event-related potentials of self-face recognition in children with pervasive developmental disorders. AN - 742775309; pmid-18590948 AB - Patients with pervasive developmental disorders (PDD) often have difficulty reading facial expressions and deciphering their implied meaning. We focused on semantic encoding related to face cognition to investigate event-related potentials (ERPs) to the subject's own face and familiar faces in children with and without PDD. Eight children with PDD (seven boys and one girl; aged 10.8+/-2.9 years; one left-handed) and nine age-matched typically developing children (four boys and five girls; aged 11.3+/-2.3 years; one left-handed) participated in this study. The stimuli consisted of three face images (self, familiar, and unfamiliar faces), one scrambled face image, and one object image (e.g., cup) with gray scale. We confirmed three major components: N170 and early posterior negativity (EPN) in the occipito-temporal regions (T5 and T6) and P300 in the parietal region (Pz). An enhanced N170 was observed as a face-specific response in all subjects. However, semantic encoding of each face might be unrelated to N170 because the amplitude and latency were not significantly different among the face conditions. On the other hand, an additional component after N170, EPN which was calculated in each subtracted waveform (self vs. familiar and familiar vs. unfamiliar), indicated self-awareness and familiarity with respect to face cognition in the control adults and children. Furthermore, the P300 amplitude in the control adults was significantly greater in the self-face condition than in the familiar-face condition. However, no significant differences in the EPN and P300 components were observed among the self-, familiar-, and unfamiliar-face conditions in the PDD children. The results suggest a deficit of semantic encoding of faces in children with PDD, which may be implicated in their delay in social communication. JF - Brain & development AU - Gunji, Atsuko AU - Inagaki, Masumi AU - Inoue, Yuki AU - Takeshima, Yasuyuki AU - Kaga, Makiko AD - Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8553, Japan. agunji@ncnp.go.jp Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 139 EP - 147 VL - 31 IS - 2 SN - 0387-7604, 0387-7604 KW - Index Medicus KW - National Library of Medicine KW - Humans KW - Electroencephalography KW - Child KW - Event-Related Potentials, P300 KW - Prosopagnosia -- physiopathology KW - Brain Mapping KW - Electrooculography KW - Evoked Potentials KW - Body Image KW - Adolescent KW - Face KW - Female KW - Male KW - Recognition (Psychology) -- physiology KW - Brain -- physiopathology KW - Asperger Syndrome -- physiopathology KW - Self Concept KW - Pattern Recognition, Visual -- physiology KW - Autistic Disorder -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742775309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%26+development&rft.atitle=Event-related+potentials+of+self-face+recognition+in+children+with+pervasive+developmental+disorders.&rft.au=Gunji%2C+Atsuko%3BInagaki%2C+Masumi%3BInoue%2C+Yuki%3BTakeshima%2C+Yasuyuki%3BKaga%2C+Makiko&rft.aulast=Gunji&rft.aufirst=Atsuko&rft.date=2009-02-01&rft.volume=31&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Brain+%26+development&rft.issn=03877604&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-13 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Increase in tiagabine serum concentration with coadministration of gemfibrozil. AN - 67204433; 19193595 AB - To report a case of possible acute tiagabine toxicity secondary to administration of gemfibrozil. A 39-year-old male was taking tiagabine 16 mg orally 3 times per day and carbamazepine 500 mg orally twice per day for complex partial seizures secondary to mesial temporal sclerosis. He was found to have type IV hypertriglyceridemia and was prescribed gemfibrozil. Because he reported severe confusion and altered consciousness shortly after a single 600-mg dose of gemfibrozil, he was admitted for controlled challenge with that drug. A single 300-mg dose of gemfibrozil resulted in lightheadedness and led to a 59% and 75% increase in total tiagabine serum concentrations at 2 and 5 hours, respectively, without significant change in baseline carbamazepine concentrations. This is the first report of an interaction between the widely used antihyperlipidemic drug gemfibrozil and tiagabine. Since tiagabine, which was originally developed as an antiepileptic medication, is now being used widely for a variety of other indications such as anxiety and depression, there is an increased risk for clinically significant interactions with gemfibrozil. Increased total and unbound tiagabine concentrations following a single 300-mg dose of gemfibrozil and reproduction of clinical symptoms with gemfibrozil rechallenge suggests the toxicity our patient experienced was due to a pharmacokinetic drug interaction. Use of the Horn Drug Interaction Probability Scale showed a probable interaction between gemfibrozil and tiagabine. JF - The Annals of pharmacotherapy AU - Burstein, Aaron H AU - Boudreau, Eilis A AU - Theodore, William H AD - Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 379 EP - 382 VL - 43 IS - 2 KW - Anticonvulsants KW - 0 KW - Hypolipidemic Agents KW - Nipecotic Acids KW - Gemfibrozil KW - Q8X02027X3 KW - tiagabine KW - Z80I64HMNP KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Interactions KW - Humans KW - Adult KW - Male KW - Anticonvulsants -- pharmacokinetics KW - Gemfibrozil -- administration & dosage KW - Nipecotic Acids -- blood KW - Nipecotic Acids -- adverse effects KW - Anticonvulsants -- adverse effects KW - Nipecotic Acids -- administration & dosage KW - Hypolipidemic Agents -- administration & dosage KW - Anticonvulsants -- administration & dosage KW - Hypolipidemic Agents -- adverse effects KW - Gemfibrozil -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67204433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Humanized+mouse+lines+and+their+application+for+prediction+of+human+drug+metabolism+and+toxicological+risk+assessment.&rft.au=Cheung%2C+Connie%3BGonzalez%2C+Frank+J&rft.aulast=Cheung&rft.aufirst=Connie&rft.date=2008-11-01&rft.volume=327&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.141242 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-07 N1 - Date created - 2009-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1345/aph.1L080 ER - TY - JOUR T1 - Spontaneous fracture: multiple causes. AN - 67015455; 19275452 AB - Spontaneous fractures occur in seemingly normal bone with no apparent blunt-force trauma. Spontaneous fracture occurs primarily in two distinct groups of patients: the very active young and the elderly. Researchers and clinicians have used several terms interchangeably for spontaneous fracture, including pathologic fracture, fragility fracture, compression fracture, or fatigue or insufficiency fracture. Among the most common causes of spontaneous fracture are osteoporosis (calcium deficiency and corticosteroid-induced), malignancy, overexposure to vitamin A, periprosthetic weakening, Brucellosis, cerebral palsy (especially in children), and osteodystrophy because of chronic renal failure. Preliminary research observations indicate that spontaneous fracture may be a rare adverse outcome associated with bisphosphonates. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Wick, Jeannette Y AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 100 EP - 2, 105-8, 110-2 VL - 24 IS - 2 SN - 0888-5109, 0888-5109 KW - Diphosphonates KW - 0 KW - Index Medicus KW - Prosthesis Failure KW - Neoplasms -- complications KW - Diphosphonates -- adverse effects KW - Risk Factors KW - Hypervitaminosis A -- complications KW - Humans KW - Cerebral Palsy -- complications KW - Brucellosis -- complications KW - Chronic Kidney Disease-Mineral and Bone Disorder -- complications KW - Osteoporosis -- complications KW - Kidney Failure, Chronic -- complications KW - Fractures, Spontaneous -- etiology KW - Fractures, Spontaneous -- microbiology KW - Fractures, Spontaneous -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67015455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Spontaneous+fracture%3A+multiple+causes.&rft.au=Wick%2C+Jeannette+Y&rft.aulast=Wick&rft.aufirst=Jeannette&rft.date=2009-02-01&rft.volume=24&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-01 N1 - Date created - 2009-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Coal use, stove improvement, and adult pneumonia mortality in Xuanwei, China: a retrospective cohort study. AN - 66999221; 19270797 AB - In Xuanwei County, China, unvented indoor coal burning is strongly associated with increased risk of lung cancer and chronic obstructive pulmonary disease. However, the impact of coal burning and stove improvement on risk of pneumonia is not clear. We conducted a retrospective cohort study among all farmers born 1917 through 1951 and living in Xuanwei as of 1 January 1976. The analysis included a total of 42,422 cohort members. Follow-up identified all deaths in the cohort from 1976 through 1996. Ages at entry into and at exit from follow-up ranged from 24 to 59 years and from 25 to 80 years, respectively. The record search detected 225 deaths from pneumonia, and 32,332 (76%) were alive as of 31 December 1996. We constructed multivariable Cox models (time variable = age) to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Use of coal, especially smokeless coal, was positively associated with pneumonia mortality. Annual tonnage and lifetime duration of smoky and smokeless coal use were positively associated with pneumonia mortality. Stove improvement was associated with a 50% reduction in pneumonia deaths (smoky coal users: HR, 0.521; 95% CI, 0.340-0.798; smokeless coal users: HR, 0.449; 95% CI, 0.215-0.937). Our analysis is the first to suggest that indoor air pollution from unvented coal burning is an important risk factor for pneumonia death in adults and that improving ventilation by installing a chimney is an effective measure to decrease it. JF - Environmental health perspectives AU - Shen, Min AU - Chapman, Robert S AU - Vermeulen, Roel AU - Tian, Linwei AU - Zheng, Tongzhang AU - Chen, Bingshu E AU - Engels, Eric A AU - He, Xingzhou AU - Blair, Aaron AU - Lan, Qing AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892-7240 , USA. shenmi@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 261 EP - 266 VL - 117 IS - 2 SN - 0091-6765, 0091-6765 KW - Coal KW - 0 KW - Index Medicus KW - coal KW - indoor air pollution KW - pneumonia KW - cohort study KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - China -- epidemiology KW - Cohort Studies KW - Adult KW - Retrospective Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Pneumonia -- chemically induced KW - Coal -- adverse effects KW - Pneumonia -- mortality KW - Pneumonia -- epidemiology KW - Household Articles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66999221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+physiology&rft.atitle=The+P2X7+receptor+channel+pore+dilates+under+physiological+ion+conditions.&rft.au=Yan%2C+Zonghe%3BLi%2C+Shuo%3BLiang%2C+Zhaodong%3BTomi%C4%87%2C+Melanija%3BStojilkovic%2C+Stanko+S&rft.aulast=Yan&rft.aufirst=Zonghe&rft.date=2008-11-01&rft.volume=132&rft.issue=5&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+physiology&rft.issn=1540-7748&rft_id=info:doi/10.1085%2Fjgp.200810059 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2009-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Occup Environ Med. 1999 Oct;56(10):679-83 [10658547] Bull World Health Organ. 2008 May;86(5):390-398C [18545742] Scand J Work Environ Health. 2000;26 Suppl 1:49-89 [11256831] Eur Respir J. 2001 Jun;17(6):1143-50 [11491157] Lancet. 2001 Aug 25;358(9282):619-24 [11530148] Natl Fam Health Surv Bull. 1997 Sep;(8):1-4 [12293014] J Natl Cancer Inst. 2002 Jun 5;94(11):826-35 [12048270] Epidemiol Infect. 2002 Aug;129(1):65-71 [12211598] Soz Praventivmed. 2004;49(4):247-53 [15357526] Science. 1987 Jan 9;235(4785):217-20 [3798109] World Health Stat Q. 1990;43(3):127-38 [2238693] Zhonghua Yu Fang Yi Xue Za Zhi. 1995 Jan;29(1):38-40 [7600888] Am J Respir Crit Care Med. 1996 Jan;153(1):3-50 [8542133] Vet Hum Toxicol. 1996 Oct;38(5):371-7 [8888547] Environ Health Perspect. 1998 May;106(5):291-7 [9560355] Epidemiology. 2005 Mar;16(2):164-74 [15703530] BMJ. 2005 Nov 5;331(7524):1050 [16234255] Int J Hyg Environ Health. 2006 Sep;209(5):445-50 [16765087] Environ Monit Assess. 2006 Nov;122(1-3):203-19 [16738762] Int J Environ Res Public Health. 2007 Mar;4(1):39-44 [17431314] Thorax. 2000 Jun;55(6):518-32 [10817802] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.11521 ER - TY - JOUR T1 - Higher incidence of Osteonecrosis of the Jaw (ONJ) in patients with metastatic castration resistant prostate cancer treated with anti-angiogenic agents. AN - 66953769; 19235596 AB - ONJ is an important toxicity in cancer patients receiving bisphosphonate therapy. Here we report a higher than usual incidence of ONJ, 11 of 60 (18.3%, 95% Confidence Interval, CI: 9%-28%) patients enrolled in a phase II clinical trial combining bevacizumab, docetaxel, thalidomide, and prednisone (ATTP) in chemotherapy-naive men with metastatic castration resistant prostate cancer (mCRPC). The use of bisphosphonates was allowed at study entry. Our study suggests that anti-angiogenic and chemotherapy agents can predispose to the development of ONJ in men with mCRPC on zoledronic acid. Imaging modalities, such as bone scans, may be useful in following the clinical course of patients who develop ONJ. JF - Cancer investigation AU - Aragon-Ching, Jeanny B AU - Ning, Yang-Min AU - Chen, Clara C AU - Latham, Lea AU - Guadagnini, Jean-Pierre AU - Gulley, James L AU - Arlen, Philip M AU - Wright, John J AU - Parnes, Howard AU - Figg, William D AU - Dahut, William L AD - Medical Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. chingj@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 221 EP - 226 VL - 27 IS - 2 KW - Angiogenesis Inhibitors KW - 0 KW - Diphosphonates KW - ibandronic acid KW - UMD7G2653W KW - Alendronate KW - X1J18R4W8P KW - Index Medicus KW - Humans KW - Adult KW - Neoplasm Metastasis KW - Incidence KW - Aged KW - Middle Aged KW - Alendronate -- adverse effects KW - Male KW - Angiogenesis Inhibitors -- therapeutic use KW - Prostatic Neoplasms -- pathology KW - Osteonecrosis -- chemically induced KW - Diphosphonates -- adverse effects KW - Osteonecrosis -- epidemiology KW - Prostatic Neoplasms -- complications KW - Jaw Diseases -- chemically induced KW - Jaw Diseases -- epidemiology KW - Prostatic Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66953769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+investigation&rft.atitle=Higher+incidence+of+Osteonecrosis+of+the+Jaw+%28ONJ%29+in+patients+with+metastatic+castration+resistant+prostate+cancer+treated+with+anti-angiogenic+agents.&rft.au=Aragon-Ching%2C+Jeanny+B%3BNing%2C+Yang-Min%3BChen%2C+Clara+C%3BLatham%2C+Lea%3BGuadagnini%2C+Jean-Pierre%3BGulley%2C+James+L%3BArlen%2C+Philip+M%3BWright%2C+John+J%3BParnes%2C+Howard%3BFigg%2C+William+D%3BDahut%2C+William+L&rft.aulast=Aragon-Ching&rft.aufirst=Jeanny&rft.date=2009-02-01&rft.volume=27&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Cancer+investigation&rft.issn=1532-4192&rft_id=info:doi/10.1080%2F07357900802208608 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-11 N1 - Date created - 2009-02-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2002 Sep;302(3):1055-61 [12183663] Ann Oncol. 2008 Mar;19(3):420-32 [17906299] Cancer Res. 2002 Nov 15;62(22):6538-44 [12438248] J Oral Maxillofac Surg. 2003 Sep;61(9):1104-7 [12966490] J Oral Maxillofac Surg. 2003 Sep;61(9):1115-7 [12966493] J Oral Maxillofac Surg. 2004 May;62(5):527-34 [15122554] Lancet. 1978 Jun 17;1(8077):1316 [78083] Head Neck Surg. 1982 Jan-Feb;4(3):251-3 [6896046] Clin Orthop Relat Res. 1986 Mar;(204):150-3 [3006960] J Bone Miner Res. 1997 Oct;12(10):1700-7 [9333131] J Bone Miner Metab. 2005;23 Suppl:36-42 [15984412] N Engl J Med. 2005 Jul 7;353(1):99-102; discussion 99-102 [16000365] N Engl J Med. 2005 Jul 7;353(1):99-102; discussion 99-102 [16003837] J Oral Maxillofac Surg. 2005 Nov;63(11):1567-75 [16243172] J Clin Oncol. 2005 Dec 1;23(34):8580-7 [16314620] Acta Oncol. 2006;45(2):216-7 [16546871] Ann Intern Med. 2006 May 16;144(10):753-61 [16702591] Nat Clin Pract Oncol. 2006 Jun;3(6):325-38 [16757970] Dentomaxillofac Radiol. 2006 Jul;35(4):236-43 [16798918] Br J Haematol. 2006 Sep;134(6):620-3 [16889620] Crit Rev Oncol Hematol. 2007 May;62(2):148-52 [17336086] Acta Oncol. 2007;46(5):664-8 [17562443] J Oral Maxillofac Surg. 2007 Jul;65(7):1328-31 [17577497] Med Oral Patol Oral Cir Bucal. 2007 Aug;12(4):E336-40 [17664922] Med Oral Patol Oral Cir Bucal. 2007 Sep;12(5):E351-6 [17767097] Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6850; author reply 6850-1 [18006788] Hell J Nucl Med. 2007 Sep-Dec;10(3):177-80 [18084661] Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3256-62 [18089719] J Musculoskelet Neuronal Interact. 2007 Oct-Dec;7(4):354-5 [18094510] J Natl Cancer Inst. 2002 Oct 2;94(19):1458-68 [12359855] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/07357900802208608 ER - TY - JOUR T1 - Application of a flow cytometric cytotoxicity assay for monitoring cancer vaccine trials. AN - 66953183; 19238018 AB - In this study, we evaluated the applicability of a flow cytometry-based cytotoxicity (FC) assay previously developed by our laboratory, for monitoring cancer vaccine trials. The assay simultaneously measures effector cell degranulation and target cell death. Clinically relevant samples consisted of frozen peripheral blood mononuclear cells (PBMC) from vaccinated melanoma patients with known response to the melanoma peptide g209. Both PBMC and 7 day in vitro-stimulated lymphocyte from patient samples were used as effector cells in the FC assay. Activity against the relevant g209 and the control g280 peptide measured in the FC assay was directly compared with results obtained from the Granzyme B enzyme-linked immunosorbent spot assay and the standard 51Cr-release assay run in tandem. The FC assay detected low or no activity when PBMC were used as effector cells. Using cytotoxic T lymphocytes as effector cells, little or no effector cell degranulation or cytotoxicity was measured in the FC assay in prevaccination samples. After vaccination, an increase in both degranulation and target cell death could be determined when target cells were pulsed with g209. No or low reactivity was found against g280 at any time point. Our findings exhibited excellent correlation between CD107a expression and GrB secretion and also Annexin V binding to target cells and specific lysis measured in the 51Cr-release assay. Results obtained from the FC assay were highly reproducible. Therefore, the FC assay may be applied to vaccine trial monitoring and allows the measurement of effector cell degranulation and target cell death simultaneously in a single sample. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Zaritskaya, Liubov AU - Shafer-Weaver, Kimberly A AU - Gregory, Melissa K AU - Strobl, Susan L AU - Baseler, Michael AU - Malyguine, Anatoli AD - Laboratory of Cell Mediated Immunity, Applied and Developmental Research Support Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA. PY - 2009 SP - 186 EP - 194 VL - 32 IS - 2 KW - Cancer Vaccines KW - 0 KW - Granzymes KW - EC 3.4.21.- KW - Index Medicus KW - Sensitivity and Specificity KW - Cytotoxicity, Immunologic KW - Reproducibility of Results KW - Humans KW - Granzymes -- immunology KW - Clinical Trials as Topic KW - Enzyme-Linked Immunosorbent Assay KW - T-Lymphocytes, Cytotoxic -- immunology KW - Cell Degranulation -- immunology KW - Cancer Vaccines -- immunology KW - Skin Neoplasms -- immunology KW - Monitoring, Immunologic -- methods KW - Cancer Vaccines -- therapeutic use KW - Skin Neoplasms -- therapy KW - Cytotoxicity Tests, Immunologic KW - Melanoma -- therapy KW - Melanoma -- immunology KW - Flow Cytometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66953183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Application+of+a+flow+cytometric+cytotoxicity+assay+for+monitoring+cancer+vaccine+trials.&rft.au=Zaritskaya%2C+Liubov%3BShafer-Weaver%2C+Kimberly+A%3BGregory%2C+Melissa+K%3BStrobl%2C+Susan+L%3BBaseler%2C+Michael%3BMalyguine%2C+Anatoli&rft.aulast=Zaritskaya&rft.aufirst=Liubov&rft.date=2009-02-01&rft.volume=32&rft.issue=2&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=1537-4513&rft_id=info:doi/10.1097%2FCJI.0b013e318197b1b2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-06 N1 - Date created - 2009-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CJI.0b013e318197b1b2 ER - TY - JOUR T1 - COMT Val158Met and cognition: main effects and interaction with educational attainment. AN - 66932778; 19076243 AB - Studies in children have shown that the genetic influence on cognition is positively correlated with socioeconomic status. Catechol-O-methyltransferase (COMT) Val158Met, a common, functional polymorphism, has been implicated in executive cognition and working memory. Imaging studies have shown that the variant Met allele is associated with more efficient prefrontal cortical processing and better attention but also emotional vulnerability to stress. We hypothesized that COMT Val158Met genotype would interact with years of education (yrs ed), one indicator of socioeconomic adversity, to predict cognitive task performance. We therefore administered the Wechsler Adult Intelligence Scale-Revised (WAIS-R) to 328 community-derived, genotyped, Plains American Indians (mean yrs ed = 12; range = 5-18). We found significant genotypic effects on WAIS-R measures of long-term memory, working memory and attention. The Met allele was associated with improved performance in the Information and Picture Completion subscales; Met/Met homozygotes performed the best. COMT genotype interacted with yrs ed to influence Information and Block Design scores: Met allele carriers' scores improved markedly with increasing yrs ed, whereas the scores of Val/Val individuals were only marginally influenced by yrs ed. There was a crossover of effects at 11-12 yrs ed: in the less educated group, Met allele carriers actually performed worse than Val/Val individuals perhaps because of emotional vulnerability to educational adversity, but in the better educated group, Met allele carriers excelled. Our study in Plains American Indians has shown that COMT Val158Met influences several aspects of cognition and some of its effects are moderated by educational adversity. JF - Genes, brain, and behavior AU - Enoch, M-A AU - Waheed, J F AU - Harris, C R AU - Albaugh, B AU - Goldman, D AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892-9412, USA. maenoch@niaaa.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 36 EP - 42 VL - 8 IS - 1 KW - DNA KW - 9007-49-2 KW - Catechol O-Methyltransferase KW - EC 2.1.1.6 KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Rural Population KW - Polymorphism, Genetic -- genetics KW - Humans KW - Alcoholism -- psychology KW - Wechsler Scales KW - Genotype KW - Oklahoma KW - Indians, North American KW - Alcoholism -- epidemiology KW - Cultural Deprivation KW - Social Class KW - Adult KW - DNA -- genetics KW - Middle Aged KW - Neuropsychological Tests KW - Female KW - Male KW - Cognition -- physiology KW - Catechol O-Methyltransferase -- genetics KW - Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66932778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+brain%2C+and+behavior&rft.atitle=COMT+Val158Met+and+cognition%3A+main+effects+and+interaction+with+educational+attainment.&rft.au=Enoch%2C+M-A%3BWaheed%2C+J+F%3BHarris%2C+C+R%3BAlbaugh%2C+B%3BGoldman%2C+D&rft.aulast=Enoch&rft.aufirst=M-A&rft.date=2009-02-01&rft.volume=8&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Genes%2C+brain%2C+and+behavior&rft.issn=1601-183X&rft_id=info:doi/10.1111%2Fj.1601-183X.2008.00441.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-11 N1 - Date created - 2009-02-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Child Dev. 1999 Sep-Oct;70(5):1151-62 [10546338] Neuropsychopharmacology. 2008 Dec;33(13):3037-45 [17805313] Annu Rev Psychol. 2002;53:463-90 [11752493] Am J Psychiatry. 2002 Apr;159(4):652-4 [11925305] Psychiatr Genet. 2003 Mar;13(1):33-41 [12605099] Br Med Bull. 2003;65:259-70 [12697630] J Stud Alcohol. 2003 Jul;64(4):458-66 [12921187] Psychol Sci. 2003 Nov;14(6):623-8 [14629696] J Neurosci. 2004 Jun 9;24(23):5331-5 [15190105] Behav Genet. 2004 Sep;34(5):533-9 [15319576] Am J Hum Genet. 2004 Nov;75(5):807-21 [15457404] Hippocampus. 1999;9(1):7-24 [10088896] Annu Rev Pharmacol Toxicol. 1999;39:19-52 [10331075] Biol Psychiatry. 1999 Aug 15;46(4):557-67 [10459407] J Neurosci. 2005 Jan 26;25(4):836-42 [15673663] Psychiatr Genet. 2005 Jun;15(2):109-15 [15900225] J Neurosci. 2005 May 18;25(20):5038-45 [15901785] Alcohol Clin Exp Res. 2006 Mar;30(3):399-406 [16499480] Biol Psychiatry. 2006 Jul 15;60(2):141-51 [16476412] Psychiatr Genet. 2006 Oct;16(5):213-6 [16969277] Biol Psychiatry. 2006 Dec 1;60(11):1250-8 [16950222] Arch Gen Psychiatry. 2006 Dec;63(12):1396-406 [17146014] Behav Genet. 2007 Mar;37(2):273-83 [16977503] Neuropsychopharmacology. 2007 May;32(5):1011-20 [17063156] Mol Psychiatry. 2007 May;12(5):502-9 [17325717] Neurosci Lett. 2007 Jun 21;421(1):57-61 [17548151] J Neurosci. 2007 Sep 19;27(38):10196-209 [17881525] Neurosci Lett. 2008 May 9;436(2):193-5 [18387741] Biol Psychiatry. 2008 Aug 15;64(4):302-10 [18436194] Alcohol Alcohol. 2008 Sep-Oct;43(5):505-15 [18477577] Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6917-22 [11381111] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1601-183X.2008.00441.x ER - TY - JOUR T1 - Assessment of lifetime cumulative sun exposure using a self-administered questionnaire: reliability of two approaches. AN - 66911334; 19190171 AB - Few studies have evaluated the reliability of lifetime sun exposure estimated from inquiring about the number of hours people spent outdoors in a given period on a typical weekday or weekend day (the time-based approach). Some investigations have suggested that women have a particularly difficult task in estimating time outdoors in adulthood due to their family and occupational roles. We hypothesized that people might gain additional memory cues and estimate lifetime hours spent outdoors more reliably if asked about time spent outdoors according to specific activities (an activity-based approach). Using self-administered, mailed questionnaires, test-retest responses to time-based and to activity-based approaches were evaluated in 124 volunteer radiologic technologist participants from the United States: 64 females and 60 males 48 to 80 years of age. Intraclass correlation coefficients (ICC) were used to evaluate the test-retest reliability of average number of hours spent outdoors in the summer estimated for each approach. We tested the differences between the two ICCs, corresponding to each approach, using a t test with the variance of the difference estimated by the jackknife method. During childhood and adolescence, the two approaches gave similar ICCs for average numbers of hours spent outdoors in the summer. By contrast, compared with the time-based approach, the activity-based approach showed significantly higher ICCs during adult ages (0.69 versus 0.43, P = 0.003) and over the lifetime (0.69 versus 0.52, P = 0.05); the higher ICCs for the activity-based questionnaire were primarily derived from the results for females. Research is needed to further improve the activity-based questionnaire approach for long-term sun exposure assessment. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Yu, Chu-Ling AU - Li, Yan AU - Freedman, D Michal AU - Fears, Thomas R AU - Kwok, Richard AU - Chodick, Gabriel AU - Alexander, Bruce AU - Kimlin, Michael G AU - Kricker, Anne AU - Armstrong, Bruce K AU - Linet, Martha S AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD 20892-7238, USA. yuchu@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 464 EP - 471 VL - 18 IS - 2 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - United States KW - Self Disclosure KW - Leisure Activities KW - Analysis of Variance KW - Reproducibility of Results KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Mental Recall KW - Male KW - Female KW - Surveys and Questionnaires KW - Environmental Exposure KW - Sunlight UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66911334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Assessment+of+lifetime+cumulative+sun+exposure+using+a+self-administered+questionnaire%3A+reliability+of+two+approaches.&rft.au=Yu%2C+Chu-Ling%3BLi%2C+Yan%3BFreedman%2C+D+Michal%3BFears%2C+Thomas+R%3BKwok%2C+Richard%3BChodick%2C+Gabriel%3BAlexander%2C+Bruce%3BKimlin%2C+Michael+G%3BKricker%2C+Anne%3BArmstrong%2C+Bruce+K%3BLinet%2C+Martha+S&rft.aulast=Yu&rft.aufirst=Chu-Ling&rft.date=2009-02-01&rft.volume=18&rft.issue=2&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0894 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-16 N1 - Date created - 2009-02-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):231-52 [11477521] J Photochem Photobiol B. 2001 Oct;63(1-3):8-18 [11684447] Occup Environ Med. 2002 Apr;59(4):257-62 [11934953] Int J Epidemiol. 2002 Apr;31(2):439-46 [11980813] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] BMJ. 2003 Aug 9;327(7410):316 [12907484] Biometrics. 1977 Mar;33(1):159-74 [843571] Phys Med Biol. 1991 Mar;36(3):299-328 [1645473] Cancer. 1992 Jan 15;69(2):586-98 [1728391] Int J Cancer. 1995 Feb 8;60(4):482-8 [7829261] Prev Med. 1997 Jul-Aug;26(4):401-7 [9245656] Cancer Epidemiol Biomarkers Prev. 1998 Oct;7(10):857-63 [9796629] Cancer Epidemiol Biomarkers Prev. 1999 May;8(5):399-406 [10350434] Cutis. 1999 Jul;64(1):37-42 [10431670] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2427-32 [16214927] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1538-44 [16896046] Cancer Causes Control. 2006 Oct;17(8):1045-52 [16933055] Ann Epidemiol. 2007 Feb;17(2):106-11 [16882464] Am J Epidemiol. 2007 Mar 15;165(6):719-26 [17204514] Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):396-400 [17337644] Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1283-6 [17548698] Int J Cancer. 2008 Jan 1;122(1):144-54 [17708556] J Natl Cancer Inst. 2007 Nov 7;99(21):1594-602 [17971526] Photochem Photobiol. 2008 May-Jun;84(3):713-8 [18435619] Photochem Photobiol. 2009 Jan-Feb;85(1):45-9 [18643910] Lancet. 2001 Aug 25;358(9282):641-2 [11530156] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0894 ER - TY - JOUR T1 - Trastuzumab plus weekly epirubicin and paclitaxel for locally advanced and metastatic breast cancer: preliminary results of a feasibility-phase II study aimed at cardiotoxicity. AN - 66909911; 19209027 AB - A feasibility-phase II study was conducted to assess the cardiotoxicity of weekly trastuzumab, epirubicin, and paclitaxel in patients with human epidermal growth factor receptor-2-positive metastatic breast cancer. Untreated patients with human epidermal growth factor receptor-2-positive advanced breast cancer received trastuzumab (day 1), and epirubicin (25 mg/m2) and paclitaxel (80 mg/m2) (day 2) on a weekly basis. The rate of patients with left-ventricular ejection fraction (L-VEF) reduction greater than 10% after 12 weeks was the primary end point. According to a two-stage model, an initial step with 15 patients was required; after 11 patients without toxicity, a second step with 21 patients was planned. After 255 courses in 15 patients (median treatment weeks: 18), the relative dose intensity was 94.7%. At 12 weeks, three patients (20%) displayed a L-VEF reduction greater than 10%, six and six (40%) patients showed a L-VEF reduction < or =10% or no change, respectively. Baseline, -12 weeks, and -24 weeks median L-VEF was 69% (range 61-77), 65% (range 60-76), and 65% (range 55-73), respectively. No EKG/cardiac signs were present. Thirteen patients had grade 3 alopecia and two patients had grade 3 asthenia, in the absence of severe hematological toxicity. Objective responses were observed in 11 patients (73.3%, 95% confidence interval 51.0-95.7), with 10 partial. The weekly administration of trastuzumab-epirubicin-paclitaxel is extremely tolerable, also with regard to L-VEF reduction. These results allowed entrance to the second step of the study. JF - Anti-cancer drugs AU - Nisticò, Cecilia AU - Bria, Emilio AU - Vaccaro, Vanja AU - Cuppone, Federica AU - Fornier, Monica AU - Sperduti, Isabella AU - Carpino, Armando AU - Izzo, Fiorentino AU - Tropea, Francesco AU - Cognetti, Francesco AU - Terzoli, Edmondo AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, Rome, Italy. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 109 EP - 114 VL - 20 IS - 2 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Epirubicin KW - 3Z8479ZZ5X KW - Trastuzumab KW - P188ANX8CK KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Ventricular Function, Left -- drug effects KW - Disease-Free Survival KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - Aged KW - Antineoplastic Agents -- adverse effects KW - Feasibility Studies KW - Survival Rate KW - Neoplasm Metastasis -- drug therapy KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Stroke Volume -- drug effects KW - Antineoplastic Agents -- therapeutic use KW - Female KW - Breast Neoplasms -- drug therapy KW - Paclitaxel -- administration & dosage KW - Heart -- drug effects KW - Paclitaxel -- therapeutic use KW - Epirubicin -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antibodies, Monoclonal -- administration & dosage KW - Antibodies, Monoclonal -- therapeutic use KW - Paclitaxel -- adverse effects KW - Breast Neoplasms -- pathology KW - Epirubicin -- therapeutic use KW - Antibodies, Monoclonal -- adverse effects KW - Epirubicin -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66909911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Trastuzumab+plus+weekly+epirubicin+and+paclitaxel+for+locally+advanced+and+metastatic+breast+cancer%3A+preliminary+results+of+a+feasibility-phase+II+study+aimed+at+cardiotoxicity.&rft.au=Nistic%C3%B2%2C+Cecilia%3BBria%2C+Emilio%3BVaccaro%2C+Vanja%3BCuppone%2C+Federica%3BFornier%2C+Monica%3BSperduti%2C+Isabella%3BCarpino%2C+Armando%3BIzzo%2C+Fiorentino%3BTropea%2C+Francesco%3BCognetti%2C+Francesco%3BTerzoli%2C+Edmondo&rft.aulast=Nistic%C3%B2&rft.aufirst=Cecilia&rft.date=2009-02-01&rft.volume=20&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=1473-5741&rft_id=info:doi/10.1097%2FCAD.0b013e32831bc09b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2009-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CAD.0b013e32831bc09b ER - TY - JOUR T1 - DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway. AN - 66908569; 18923442 AB - DLC1 (deleted in liver cancer 1), a tumor suppressor gene that encodes a RhoGTPase-activating protein, is recurrently downregulated or silenced in various solid tumors and hematological malignancies because of epigenetic modifications or genomic deletion. Here, we identified DLC1 promoter hypermethylation in 43 out of 44 multiple myeloma (MM) cell lines, which resulted in downregulation or silencing of DLC1 in 41 samples. High frequency of tumor-specific methylation and attenuation or silencing of DLC1 expression could serve as an independent diagnostic marker for MM. Combined treatment with demethylating and acetylating agents significantly elevated the expression of DLC1 and suppressed MM cell proliferation. Two cell lines exhibiting complete promoter methylation and the absence of DLC1 expression were transduced by an adenoviral vector containing DLC1 cDNA. In both cell lines, the reexpression of DLC1 inhibited myeloma cell invasion and migration, reduced RhoA activity and resulted in the reorganization of actin cytoskeleton. These results provide the first evidence for the antiproliferative effect of DLC1 in a hematological cancer and implicate RhoA pathway in suppression of MM migration and invasion. Given the myeloma cells sensitivity to the reactivation of DLC1 function, the potential for molecular targeted therapy of DLC1-mediated pathways as well as epigenetic therapies hold prospects. JF - Leukemia AU - Ullmannova-Benson, V AU - Guan, M AU - Zhou, X AU - Tripathi, V AU - Yang, X-Y AU - Zimonjic, D B AU - Popescu, N C AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-4262, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 383 EP - 390 VL - 23 IS - 2 KW - DLC1 protein, human KW - 0 KW - GTPase-Activating Proteins KW - Tumor Suppressor Proteins KW - rhoA GTP-Binding Protein KW - EC 3.6.5.2 KW - Index Medicus KW - Young Adult KW - Promoter Regions, Genetic KW - DNA Methylation KW - Gene Silencing KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Cell Line, Tumor KW - Male KW - Female KW - Cell Movement KW - rhoA GTP-Binding Protein -- metabolism KW - Neoplasm Invasiveness KW - Tumor Suppressor Proteins -- physiology KW - Multiple Myeloma -- pathology KW - Tumor Suppressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66908569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=DLC1+tumor+suppressor+gene+inhibits+migration+and+invasion+of+multiple+myeloma+cells+through+RhoA+GTPase+pathway.&rft.au=Ullmannova-Benson%2C+V%3BGuan%2C+M%3BZhou%2C+X%3BTripathi%2C+V%3BYang%2C+X-Y%3BZimonjic%2C+D+B%3BPopescu%2C+N+C&rft.aulast=Ullmannova-Benson&rft.aufirst=V&rft.date=2009-02-01&rft.volume=23&rft.issue=2&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=1476-5551&rft_id=info:doi/10.1038%2Fleu.2008.285 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-02 N1 - Date created - 2009-02-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Cancer. 2002 Mar;2(3):175-87 [11990854] PLoS One. 2008;3(7):e2779 [18648664] Ann N Y Acad Sci. 2002 Nov;973:124-36 [12485848] Oncogene. 2003 Mar 13;22(10):1536-45 [12629517] Nat Rev Cancer. 2002 Feb;2(2):133-42 [12635176] N Engl J Med. 2003 Nov 20;349(21):2042-54 [14627790] Cancer Res. 2003 Nov 15;63(22):7646-51 [14633684] Blood. 2004 Jan 1;103(1):301-8 [14504085] Cancer Cell. 2004 Aug;6(2):151-8 [15324698] Leukemia. 2004 Oct;18(10):1687-92 [15318245] Exp Cell Res. 2004 Nov 15;301(1):43-9 [15501444] Nature. 1982 Jul 22;298(5872):343-7 [6283384] Nature. 1997 May 15;387(6630):292-5 [9153394] Science. 1998 Jan 23;279(5350):509-14 [9438836] Cancer Res. 1998 May 15;58(10):2196-9 [9605766] Mol Cell. 2005 Jan 21;17(2):205-14 [15664190] FEBS Lett. 2005 Feb 14;579(5):1191-6 [15710412] Bioessays. 2005 Jun;27(6):602-13 [15892119] Cancer Res. 2005 Jul 15;65(14):6042-53 [16024604] Blood. 2005 Sep 1;106(5):1786-93 [15886323] J Clin Oncol. 2005 Sep 10;23(26):6333-8 [16155016] Annu Rev Cell Dev Biol. 2005;21:247-69 [16212495] Clin Cancer Res. 2006 Mar 1;12(5):1412-9 [16533763] Cancer Cell. 2006 Apr;9(4):313-25 [16616336] Cancer Res. 2006 Jun 15;66(12):6361-9 [16778214] J Clin Pathol. 2006 Sep;59(9):947-51 [16489177] Carcinogenesis. 2007 Jan;28(1):60-70 [16774933] Cancer Lett. 2007 Feb 8;246(1-2):92-9 [16540234] Cancer Res. 2007 Mar 15;67(6):2617-25 [17363581] Hepatology. 2007 May;45(5):1298-305 [17464972] Proc Natl Acad Sci U S A. 2007 May 22;104(21):9012-7 [17517630] J Immunol. 2007 Aug 1;179(3):1634-47 [17641030] Nat Rev Cancer. 2007 Aug;7(8):585-98 [17646864] Exp Cell Res. 2007 Nov 1;313(18):3868-80 [17888903] Epigenetics. 2007 Jan-Mar;2(1):15-21 [17965626] J Cell Mol Med. 2007 Sep-Oct;11(5):1185-207 [17979893] Blood. 2008 Feb 1;111(3):1060-6 [17962510] Int J Biochem Cell Biol. 2008;40(5):874-91 [18280770] Blood. 2008 Mar 15;111(6):2962-72 [18332230] Mol Carcinog. 2008 May;47(5):326-37 [17932950] Genes Chromosomes Cancer. 2008 Jul;47(7):573-90 [18381641] Cancer Gene Ther. 2008 Jun;15(6):371-81 [18369381] Leukemia. 2008 May;22(5):1035-43 [18288132] Int J Oncol. 2008 Jun;32(6):1285-91 [18497990] Genes Dev. 2008 Jun 1;22(11):1439-44 [18519636] Genes Dev. 2008 Jul 1;22(13):1724-30 [18593873] Nat Rev Genet. 2002 Jun;3(6):415-28 [12042769] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/leu.2008.285 ER - TY - JOUR T1 - Telomere length, current perceived stress, and urinary stress hormones in women. AN - 66906015; 19190150 AB - Telomeres are repetitive DNA sequences that cap and protect the ends of chromosomes; critically short telomeres may lead to cellular senescence or carcinogenic transformation. Previous findings suggest a link between psychosocial stress, shorter telomeres, and chronic disease risk. This cross-sectional study examined relative telomere length in relation to perceived stress and urinary stress hormones in a sample of participants (n = 647) in the National Institute of Environmental Health Sciences Sister Study, a cohort of women ages 35 to 74 years who have a sister with breast cancer. Average leukocyte telomere length was determined by quantitative PCR. Current stress was assessed using the Perceived Stress Scale and creatinine-adjusted neuroendocrine hormones in first morning urines. Linear regression models estimated differences in telomere length base pairs (bp) associated with stress measures adjusted for age, race, smoking, and obesity. Women with higher perceived stress had somewhat shorter telomeres [adjusted difference of -129bp for being at or above moderate stress levels; 95% confidence interval (CI), -292 to 33], but telomere length did not decrease monotonically with higher stress levels. Shorter telomeres were independently associated with increasing age (-27bp/year), obesity, and current smoking. Significant stress-related differences in telomere length were seen in women ages 55 years and older (-289bp; 95% CI, -519 to -59), those with recent major losses (-420bp; 95% CI, -814 to -27), and those with above-average urinary catecholamines (e.g., epinephrine: -484bp; 95% CI, -709 to -259). Although current perceived stress was only modestly associated with shorter telomeres in this broad sample of women, our findings suggest the effect of stress on telomere length may vary depending on neuroendocrine responsiveness, external stressors, and age. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Parks, Christine G AU - Miller, Diane B AU - McCanlies, Erin C AU - Cawthon, Richard M AU - Andrew, Michael E AU - DeRoo, Lisa A AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27599, USA. Parks1@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 551 EP - 560 VL - 18 IS - 2 SN - 1055-9965, 1055-9965 KW - Catecholamines KW - 0 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Cross-Sectional Studies KW - Age Factors KW - Prospective Studies KW - Risk Factors KW - Humans KW - Linear Models KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Telomere -- ultrastructure KW - Catecholamines -- urine KW - Hydrocortisone -- urine KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66906015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Telomere+length%2C+current+perceived+stress%2C+and+urinary+stress+hormones+in+women.&rft.au=Parks%2C+Christine+G%3BMiller%2C+Diane+B%3BMcCanlies%2C+Erin+C%3BCawthon%2C+Richard+M%3BAndrew%2C+Michael+E%3BDeRoo%2C+Lisa+A%3BSandler%2C+Dale+P&rft.aulast=Parks&rft.aufirst=Christine&rft.date=2009-02-01&rft.volume=18&rft.issue=2&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0614 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-16 N1 - Date created - 2009-02-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychoneuroendocrinology. 2006 Apr;31(3):277-87 [16298085] Psychoneuroendocrinology. 2005 Nov;30(10):1010-6 [15950390] Metabolism. 2006 Oct;55(10 Suppl 2):S20-3 [16979422] Aging Cell. 2006 Oct;5(5):361-5 [16856882] Lancet. 2007 Jan 13;369(9556):107-14 [17223473] Int J Epidemiol. 2006 Dec;35(6):1424-9 [16997848] Cancer Res. 2007 Feb 15;67(4):1415-8 [17308077] J Clin Endocrinol Metab. 2007 Mar;92(3):819-24 [17179195] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9 [17416776] Psychiatr Genet. 2007 Jun;17(3):195-9 [17417064] Chest. 2007 May;131(5):1557-66 [17494805] Physiol Behav. 2007 Jun 8;91(2-3):208-11 [17433386] Am J Epidemiol. 2007 Aug 15;166(4):447-55 [17556763] J Immunol. 2007 Sep 15;179(6):4249-54 [17785865] J Trauma Stress. 2007 Aug;20(4):611-7 [17721974] Lab Invest. 2007 Nov;87(11):1071-6 [17767195] Diabetes Care. 2007 Nov;30(11):2909-15 [17666463] Stress. 2007 Nov;10(4):351-61 [17853062] J Neuroimmunol. 2000 Jan 24;102(2):113-24 [10636479] Neuroendocrinology. 1999 Dec;70(6):422-30 [10657735] J Gerontol A Biol Sci Med Sci. 2000 Oct;55(10):M618-24 [11034236] Mech Ageing Dev. 2000 Nov 15;119(3):89-99 [11080530] Nucleic Acids Res. 2002 May 15;30(10):e47 [12000852] Lancet. 2003 Feb 1;361(9355):393-5 [12573379] Horm Res. 2003;59(4):161-79 [12649570] Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9090-5 [12840146] Brain Behav Immun. 2003 Oct;17(5):350-64 [12946657] Clin Cancer Res. 2004 May 15;10(10):3317-26 [15161685] J Health Soc Behav. 1983 Dec;24(4):385-96 [6668417] Neurosci Biobehav Rev. 1984 Winter;8(4):523-30 [6514254] Pharmacol Biochem Behav. 1989 Dec;34(4):747-51 [2623029] Psychosom Med. 1999 Mar-Apr;61(2):197-204 [10204973] J Mammary Gland Biol Neoplasia. 2004 Jul;9(3):285-96 [15557801] Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17312-5 [15574496] Lancet. 2005 Aug 20-26;366(9486):662-4 [16112303] Ann N Y Acad Sci. 2004 Dec;1032:141-53 [15677401] Nat Rev Immunol. 2005 Mar;5(3):243-51 [15738954] Immunology. 2005 Jul;115(3):289-95 [15946246] Int J Psychophysiol. 2006 Mar;59(3):236-43 [16325948] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0614 ER - TY - JOUR T1 - Resurrecting clinical pharmacology as a context for Alzheimer disease drug development. AN - 66901054; 19199879 AB - Commercial priorities have been identified as negative factors in drug development. We trace the problem to inattention to sound clinical pharmacology practices. When properly applied, clinical pharmacology and associated drug development sciences can, hand in hand, facilitate success in commercial drug development. JF - Current Alzheimer research AU - Becker, Robert E AU - Unni, Latha K AU - Greig, Nigel H AD - Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. rebecker2008@comcast.net Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 79 EP - 81 VL - 6 IS - 1 KW - Cholinesterase Inhibitors KW - 0 KW - Trichlorfon KW - DBF2DG4G2K KW - Acetylcholinesterase KW - EC 3.1.1.7 KW - Index Medicus KW - Cholinesterase Inhibitors -- pharmacology KW - Cholinesterase Inhibitors -- administration & dosage KW - Animals KW - Trichlorfon -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Acetylcholinesterase -- metabolism KW - Trichlorfon -- administration & dosage KW - Drug Industry -- standards KW - Pharmacology, Clinical -- standards KW - Alzheimer Disease -- physiopathology KW - Alzheimer Disease -- drug therapy KW - Pharmacology, Clinical -- methods KW - Clinical Trials as Topic -- standards KW - Alzheimer Disease -- metabolism KW - Drug Industry -- methods KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66901054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=Resurrecting+clinical+pharmacology+as+a+context+for+Alzheimer+disease+drug+development.&rft.au=Becker%2C+Robert+E%3BUnni%2C+Latha+K%3BGreig%2C+Nigel+H&rft.aulast=Becker&rft.aufirst=Robert&rft.date=2009-02-01&rft.volume=6&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=1875-5828&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-08 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment On: Curr Alzheimer Res. 2009 Feb;6(1):77-8 [19199878] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Recent advances in prion chemotherapeutics. AN - 66897609; 19200018 AB - The transmissible spongiform encephalopathies are rapidly progressive and invariably fatal neurodegenerative diseases for which there are no proven efficacious treatments. Many approaches have been undertaken to find ways to prevent, halt, or reverse these prion diseases, with limited success to date. However, as both our understanding of pathogenesis and our ability to detect early disease increases, so do our potential therapeutic targets and our chances of finding effective drugs. There is increasing pressure to find effective decontaminants for blood supplies, as variant Creutzfeldt Jakob Disease (vCJD) has been shown to be transmissible by blood, and to find non-toxic preventative therapies, with ongoing cases of Bovine Spongiform Encephalopathy (BSE) and the spread of Chronic Wasting Disease (CWD). Within the realm of chemotherapeutic approaches, much research has focussed on blocking the conversion of the normal form of prion protein (PrP(c)) to its abnormal counterpart (PrP(res)). Structurally, these chemotherapeutic agents are often polyanionic or polycyclic and may directly bind PrP(c) or PrP(res), or act by redistributing, sequestering, or down-regulating PrP(c), thus preventing its conversion. There are also some polycationic compounds which proport to enhance the clearance of PrP(res). Other targets include accessory molecules such as the laminin receptor precursor which influences conversion, or cell signalling molecules which may be required for pathogenesis. Of recent interest are the possible neuroprotective effects of some drugs. Importantly, there is evidence that combining compounds may provide synergistic responses. This review provides an update on current testing methods, therapeutic targets, and promising candidates for chemical-based therapy. JF - Infectious disorders drug targets AU - Sim, Valerie L AU - Caughey, Byron AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. simv@niaid.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 81 EP - 91 VL - 9 IS - 1 KW - Anti-Infective Agents KW - 0 KW - PrPSc Proteins KW - Prions KW - Index Medicus KW - Prions -- chemistry KW - PrPSc Proteins -- antagonists & inhibitors KW - Animals KW - Prions -- drug effects KW - Humans KW - PrPSc Proteins -- metabolism KW - Disease Models, Animal KW - Models, Biological KW - Prions -- pathogenicity KW - Prion Diseases -- epidemiology KW - Anti-Infective Agents -- therapeutic use KW - Prion Diseases -- metabolism KW - Anti-Infective Agents -- pharmacology KW - Prion Diseases -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66897609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+disorders+drug+targets&rft.atitle=Recent+advances+in+prion+chemotherapeutics.&rft.au=Sim%2C+Valerie+L%3BCaughey%2C+Byron&rft.aulast=Sim&rft.aufirst=Valerie&rft.date=2009-02-01&rft.volume=9&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Infectious+disorders+drug+targets&rft.issn=2212-3989&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-07 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 2007 Nov;51(11):4141-7 [17709472] J Virol. 2007 Dec;81(23):12889-98 [17881452] J Biol Chem. 2007 Dec 14;282(50):36525-33 [17925394] J Gen Virol. 2008 Feb;89(Pt 2):594-7 [18198391] Eur J Med Chem. 2008 Jan;43(1):93-106 [17475368] J Neurochem. 2008 Mar;104(6):1553-64 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carcinogenesis. AN - 66888779; 19196723 AB - The statins are highly effective in lowering cholesterol by inhibiting 3-hydroxy-3-methylglutaryl CoA reductase. Recently, there has been conflicting epidemiologic data indicating that statins decrease the incidence of certain types of cancer, including breast cancer. Atorvastatin and lovastatin, statins with different lipophicilities, were administered in diet either as single agents or in combination with suboptimal doses of tamoxifen or the retinoid X receptor agonist bexarotene were evaluated for prevention of estrogen receptor-positive mammary cancers induced in the rat with methylnitrosourea. Atorvastatin (125 or 500 mg/kg diet) alone did not significantly alter cancer incidence or multiplicity. Suboptimal doses of tamoxifen (0.4 mg/kg diet) or bexarotene (80 mg/kg diet) reduced cancer multiplicity from 3.8 (control) to 2.9 and 0.9, respectively. Combining atorvastatin (500 mg/kg diet) with either of these effective agents minimally altered their efficacy. Although this dose of atorvastatin did not decrease serum triglyceride levels in control rats, it significantly decreased triglyceride levels that had been increased in bexarotene-treated rats. Experiments done with a second statin, lovastatin (100 and 400 mg/kg diet), yielded similar results: (a) limited activity when administered alone, (b) no obvious synergy with bexarotene, and (c) an ability to decrease bexarotene-induced increases in serum triglycerides. Thus, the statins had minimal activity in this model of mammary cancer in which approximately half of the cancers are mutated in the Ha Ras oncogene. Similarly, atorvastatin failed to alter the development of estrogen receptor-negative mammary carcinomas in a new animal model using bitransgenic mice (MMTV-Neu(+/-)/p53KO(+/-)), whereas bexarotene (250 mg/kg diet) was effective. JF - Cancer prevention research (Philadelphia, Pa.) AU - Lubet, Ronald A AU - Boring, Daniel AU - Steele, Vernon E AU - Ruppert, J Michael AU - Juliana, M Margaret AU - Grubbs, Clinton J AD - Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA. lubetr@nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 161 EP - 167 VL - 2 IS - 2 KW - Alkylating Agents KW - 0 KW - Anticarcinogenic Agents KW - Anticholesteremic Agents KW - Antineoplastic Agents, Hormonal KW - Heptanoic Acids KW - Pyrroles KW - Receptors, Estrogen KW - Retinoid X Receptors KW - Tetrahydronaphthalenes KW - Tumor Suppressor Protein p53 KW - Tamoxifen KW - 094ZI81Y45 KW - Atorvastatin Calcium KW - 48A5M73Z4Q KW - Methylnitrosourea KW - 684-93-5 KW - Lovastatin KW - 9LHU78OQFD KW - bexarotene KW - A61RXM4375 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Tamoxifen -- pharmacology KW - Animals KW - Tumor Suppressor Protein p53 -- physiology KW - Antineoplastic Agents, Hormonal -- pharmacology KW - Methylnitrosourea -- toxicity KW - Mice KW - Receptors, Estrogen -- metabolism KW - Mice, Transgenic KW - Genes, erbB-2 -- physiology KW - Mice, Knockout KW - Rats KW - Rats, Sprague-Dawley KW - Tetrahydronaphthalenes -- pharmacology KW - Anticarcinogenic Agents -- pharmacology KW - Apoptosis -- drug effects KW - Treatment Outcome KW - Alkylating Agents -- toxicity KW - Diet KW - Female KW - Retinoid X Receptors -- metabolism KW - Mammary Neoplasms, Experimental -- chemically induced KW - Lovastatin -- therapeutic use KW - Mammary Neoplasms, Experimental -- drug therapy KW - Disease Models, Animal KW - Heptanoic Acids -- therapeutic use KW - Anticholesteremic Agents -- therapeutic use KW - Pyrroles -- therapeutic use KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66888779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Genetics&rft.atitle=Genetic+Control+of+Variegated+KIR+Gene+Expression%3A+Polymorphisms+of+the+Bi-Directional+KIR3DL1+Promoter+Are+Associated+with+Distinct+Frequencies+of+Gene+Expression&rft.au=Li%2C+Hongchuan%3BPascal%2C+Veronique%3BMartin%2C+Maureen+P%3BCarrington%2C+Mary%3BAnderson%2C+Stephen+K%3BRoopenian%2C+Derry+C&rft.aulast=Li&rft.aufirst=Hongchuan&rft.date=2008-11-01&rft.volume=4&rft.issue=11&rft.spage=e1000254&rft.isbn=&rft.btitle=&rft.title=PLoS+Genetics&rft.issn=15537390&rft_id=info:doi/10.1371%2Fjournal.pgen.1000254 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2009-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-08-0134 ER - TY - JOUR T1 - A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma. AN - 66885546; 19029192 AB - Toll-like receptors (TLRs) may influence the development of non-Hodgkin lymphoma (NHL) given their important roles in recognizing microbial pathogens and stimulating multiple immune pathways. We conducted an investigation of TLR gene variants in a pooled analysis including three population-based case-control studies of NHL (1946 cases and 1808 controls). Thirty-six tag single-nucleotide polymorphisms (SNPs) in TLR2, TLR4 and the TLR10-TLR1-TLR6 gene cluster were genotyped. Two TLR10-TLR1-TLR6 variants in moderate linkage disequilibrium were significantly associated with NHL: rs10008492 [odds ratio for CT genotype (OR(CT)) 1.12, 95% confidence interval (CI) 0.97-1.30; OR(TT) 1.40, 95% CI 1.15-1.71; P(trend) = 0.001] and rs4833103 (OR(AC) 0.75, 95% CI 0.64-0.88; OR(AA) 0.74, 95% CI 0.62-0.90; P(trend) = 0.002; P(dominant) = 0.0002). Associations with these SNPs were consistent across all the three studies and did not appreciably differ by histologic subtype. We found little evidence of association between TLR2 variation and all NHL, although the rare variant rs3804100 was significantly associated with marginal zone lymphoma (MZL), both overall (OR(CT/CC) 1.89, 95% CI 1.27-2.81; P(dominant) = 0.002) and in two of the three studies. No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL. JF - Carcinogenesis AU - Purdue, Mark P AU - Lan, Qing AU - Wang, Sophia S AU - Kricker, Anne AU - Menashe, Idan AU - Zheng, Tong-Zhang AU - Hartge, Patricia AU - Grulich, Andrew E AU - Zhang, Yawei AU - Morton, Lindsay M AU - Vajdic, Claire M AU - Holford, Theodore R AU - Severson, Richard K AU - Leaderer, Brian P AU - Cerhan, James R AU - Yeager, Meredith AU - Cozen, Wendy AU - Jacobs, Kevin AU - Davis, Scott AU - Rothman, Nathaniel AU - Chanock, Stephen J AU - Chatterjee, Nilanjan AU - Armstrong, Bruce K AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA. purduem@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 275 EP - 281 VL - 30 IS - 2 KW - Toll-Like Receptors KW - 0 KW - Index Medicus KW - Risk KW - Polymorphism, Single Nucleotide KW - Aged, 80 and over KW - Multigene Family KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Linkage Disequilibrium KW - Male KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Toll-Like Receptors -- genetics KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66885546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=A+pooled+investigation+of+Toll-like+receptor+gene+variants+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Purdue%2C+Mark+P%3BLan%2C+Qing%3BWang%2C+Sophia+S%3BKricker%2C+Anne%3BMenashe%2C+Idan%3BZheng%2C+Tong-Zhang%3BHartge%2C+Patricia%3BGrulich%2C+Andrew+E%3BZhang%2C+Yawei%3BMorton%2C+Lindsay+M%3BVajdic%2C+Claire+M%3BHolford%2C+Theodore+R%3BSeverson%2C+Richard+K%3BLeaderer%2C+Brian+P%3BCerhan%2C+James+R%3BYeager%2C+Meredith%3BCozen%2C+Wendy%3BJacobs%2C+Kevin%3BDavis%2C+Scott%3BRothman%2C+Nathaniel%3BChanock%2C+Stephen+J%3BChatterjee%2C+Nilanjan%3BArmstrong%2C+Bruce+K&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2009-02-01&rft.volume=30&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn262 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-26 N1 - Date created - 2009-02-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] J Immunol. 2005 Aug 15;175(4):2534-40 [16081826] Ann N Y Acad Sci. 2005 Dec;1062:95-103 [16461792] Blood. 2006 May 15;107(10):4101-8 [16449530] Br J Haematol. 2006 Jul;134(2):180-3 [16740140] Genet Epidemiol. 2006 Sep;30(6):495-507 [16755536] Cancer Res. 2006 Oct 1;66(19):9771-80 [17018637] Genes Immun. 2006 Dec;7(8):615-24 [16971956] Rev Med Virol. 2007 Jan-Feb;17(1):35-43 [17146842] Arthritis Rheum. 2007 Feb 15;57(1):161-70 [17266090] Carcinogenesis. 2007 Mar;28(3):704-12 [17056605] J Immunol. 2007 May 15;178(10):6387-94 [17475868] Hum Mol Genet. 2007 May 15;16(10):1225-32 [17409197] J Immunol. 2007 Jun 15;178(12):7520-4 [17548585] Blood. 2007 Jul 15;110(2):695-708 [17389762] Eur J Immunol. 2007 Aug;37(8):2280-9 [17595679] Int Immunopharmacol. 2007 Oct;7(10):1271-85 [17673142] Crit Rev Oncol Hematol. 2007 Sep;63(3):245-56 [17583528] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):1982-9 [17932345] J Infect Dis. 2008 Jan 15;197(2):253-61 [18177245] J Allergy Clin Immunol. 2008 Apr;121(4):1013-9 [18234309] Blood. 2007 Dec 15;110(13):4455-63 [17827388] Hum Pathol. 2000 Feb;31(2):263-8 [10685647] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Methods Mol Biol. 2002;184:143-68 [11889711] Nat Med. 2002 Aug;8(8):878-84 [12091878] Blood. 2003 Aug 1;102(3):956-63 [12689944] J Biol Chem. 2003 Aug 29;278(35):32552-60 [12807870] Hum Hered. 2003;56(1-3):18-31 [14614235] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Am J Epidemiol. 2004 Jan 15;159(2):148-54 [14718216] N Engl J Med. 2004 Jan 15;350(3):239-48 [14724303] Ann Oncol. 2004 Apr;15(4):631-7 [15033672] Int J Cancer. 2004 Jun 20;110(3):429-34 [15095310] Genes Immun. 2004 Aug;5(5):343-6 [15266299] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] Am J Respir Crit Care Med. 2004 Sep 15;170(6):594-600 [15201134] J Am Acad Dermatol. 1991 Apr;24(4):584-90 [2033136] Lancet. 1993 Sep 4;342(8871):571-4 [8102718] Yale J Biol Med. 1996 Jan-Feb;69(1):61-8 [9041690] Gastroenterology. 2004 Nov;127(5):1513-24 [15521019] Eur J Gastroenterol Hepatol. 2004 Nov;16(12):1361-5 [15618846] Ann N Y Acad Sci. 2004 Dec;1037:170-4 [15699513] Infect Immun. 2005 Mar;73(3):1523-31 [15731050] Immunol Rev. 2005 Apr;204:27-42 [15790348] J Natl Cancer Inst. 2005 Apr 6;97(7):525-32 [15812078] Leuk Lymphoma. 2005 Jun;46(6):869-72 [16019531] J Clin Oncol. 2005 Aug 1;23(22):5067-73 [15968003] Lancet Oncol. 2006 Jan;7(1):27-38 [16389181] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn262 ER - TY - JOUR T1 - Monitoring for lack of benefit: a critical component of a randomized clinical trial. AN - 66881126; 19064977 AB - To balance patient interests against the need for acquiring evidence, ongoing randomized clinical trials are formally monitored for early convincing indication of benefit or lack of benefit. In lethal diseases like cancer, where new therapies are often toxic and may have limited preliminary efficacy data, monitoring for lack of benefit is particularly important. We review the complex nature of stopping a randomized trial for lack of benefit and argue that many cancer trials could be improved by a more aggressive approach to monitoring. On the other hand, we caution that some commonly used monitoring guidelines may result in stopping for lack of benefit even when a nontrivial beneficial effect is observed. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Freidlin, Boris AU - Korn, Edward L AD - Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA. freidlinb@ctep.nci.nih.gov Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 SP - 629 EP - 633 VL - 27 IS - 4 KW - Index Medicus KW - Humans KW - Guidelines as Topic KW - Research Design KW - Models, Theoretical KW - Monitoring, Physiologic -- standards KW - Randomized Controlled Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66881126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Monitoring+for+lack+of+benefit%3A+a+critical+component+of+a+randomized+clinical+trial.&rft.au=Freidlin%2C+Boris%3BKorn%2C+Edward+L&rft.aulast=Freidlin&rft.aufirst=Boris&rft.date=2009-02-01&rft.volume=27&rft.issue=4&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.17.8905 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMJ. 1992 Jul 25;305(6847):235-40 [1392832] J Clin Oncol. 2008 Mar 10;26(8):1371-8 [18227527] J Natl Cancer Inst. 1996 Dec 18;88(24):1791-3 [8961965] J Clin Oncol. 1997 Jul;15(7):2736-43 [9215848] Control Clin Trials. 1998 Dec;19(6):575-88 [9875837] Control Clin Trials. 1999 Oct;20(5):395-407 [10503800] J Clin Oncol. 2005 May 20;23(15):3509-16 [15908661] Ann Oncol. 2005 Oct;16(10):1639-45 [16087696] Ann Oncol. 2005;16 Suppl 8:viii20-viii29 [16239233] Clin Trials. 2005;2(6):519-28 [16422312] J Clin Oncol. 2006 Aug 20;24(24):3946-52 [16921047] J Clin Oncol. 2006 Sep 20;24(27):4441-7 [16983112] Clin Trials. 2006;3(6):513-21 [17170035] Clin Trials. 2006;3(6):522-9 [17170036] J Clin Oncol. 2007 May 20;25(15):1960-6 [17452677] J Clin Oncol. 2007 Jun 1;25(16):2212-7 [17538165] Lancet. 1999 Dec 4;354(9194):1983-8 [10622312] J Natl Cancer Inst. 2001 May 2;93(9):684-90 [11333290] Br J Cancer. 2002 Jul 15;87(2):161-7 [12107836] J Clin Oncol. 2002 Aug 1;20(15):3270-5 [12149301] Control Clin Trials. 2002 Aug;23(4):355-66 [12161079] Ann Oncol. 2002;13 Suppl 4:131-8 [12401679] J Clin Oncol. 2003 Sep 1;21(17):3296-302 [12947065] Lancet. 2003 Oct 18;362(9392):1255-60 [14575968] N Engl J Med. 2004 Mar 11;350(11):1143-7 [15014189] J Clin Oncol. 2004 Apr 15;22(8):1430-8 [15084616] Biometrics. 1983 Mar;39(1):227-36 [6871351] Control Clin Trials. 1984 Dec;5(4):348-61 [6518769] Cancer Treat Rep. 1985 Oct;69(10):1147-54 [4042093] J Natl Cancer Inst. 1989 Feb 1;81(3):188-93 [2642969] Oncology (Williston Park). 1990 Mar;4(3):126-33; discussion 134, 136 [2144441] Lancet. 1992 Jan 4;339(8784):1-15 [1345950] Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1008-17 [17716826] J Clin Oncol. 2007 Nov 1;25(31):5019-23 [17971602] Clin Trials. 2008;5(1):14-22 [18283075] Stat Med. 1994 Jul 15-30;13(13-14):1453-8 [7973224] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2008.17.8905 ER - TY - JOUR T1 - Phase I trial and pharmacokinetic study of ixabepilone administered daily for 5 days in children and adolescents with refractory solid tumors. AN - 66880295; 19075272 AB - The objectives of this phase I trial were to determine the maximum-tolerated dose (MTD), toxicity profile, dose-limiting toxicities (DLTs), pharmacokinetics, and preliminary response rate for ixabepilone, a microtubule-stabilizing agent, administered intravenously daily for 5 days in children and adolescents. Patients >or= 2 and 5 days and grade 3 fatigue) were observed in two of three patients receiving 10 mg/m(2)/d. The MTD of ixabepilone administered daily for 5 days every 21 days was 8 mg/m(2)/d. Myelosuppression, GI, and hepatic toxicities were common non-DLTs. Peripheral neuropathy was uncommon. Ixabepilone clearance was 475 +/- 247 mL/min/m(2), volume of distribution at steady-state was 12.2 +/- 5.4 L/kg, and half-life was 14 hours. The recommended dose of ixabepilone for phase II trials in solid tumors is 8 mg/m(2)/d daily for 5 days every 21 days. This dose is 33% higher than the MTD in adults receiving the same dosing schedule. Pharmacokinetic parameters in children and adolescents were highly variable but similar to adults. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Widemann, Brigitte C AU - Goodspeed, Wendy AU - Goodwin, Anne AU - Fojo, Tito AU - Balis, Frank M AU - Fox, Elizabeth AD - Pediatric and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. widemanb@mail.nih.gov Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 SP - 550 EP - 556 VL - 27 IS - 4 KW - Epothilones KW - 0 KW - ixabepilone KW - K27005NP0A KW - Index Medicus KW - Kidney Neoplasms -- drug therapy KW - Maximum Allowable Concentration KW - Wilms Tumor -- drug therapy KW - Liver Neoplasms -- drug therapy KW - Humans KW - Hepatoblastoma -- drug therapy KW - Child KW - Adolescent KW - Neuroblastoma KW - Male KW - Female KW - Child, Preschool KW - Epothilones -- toxicity KW - Epothilones -- pharmacokinetics KW - Sarcoma -- drug therapy KW - Epothilones -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66880295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+trial+and+pharmacokinetic+study+of+ixabepilone+administered+daily+for+5+days+in+children+and+adolescents+with+refractory+solid+tumors.&rft.au=Widemann%2C+Brigitte+C%3BGoodspeed%2C+Wendy%3BGoodwin%2C+Anne%3BFojo%2C+Tito%3BBalis%2C+Frank+M%3BFox%2C+Elizabeth&rft.aulast=Widemann&rft.aufirst=Brigitte&rft.date=2009-02-01&rft.volume=27&rft.issue=4&rft.spage=550&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/10.1200%2FJCO.2008.17.6644 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 2005 Mar 1;23(7):1439-46 [15735119] Clin Cancer Res. 1999 Apr;5(4):733-7 [10213206] Cancer. 2005 May 1;103(9):1932-8 [15800893] Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6950-8 [16203787] J Clin Oncol. 2005 Dec 1;23(34):8724-9 [16314632] J Clin Oncol. 2005 Dec 20;23(36):9048-50 [16301592] Invest New Drugs. 2006 Sep;24(5):441-6 [16586011] Clin Cancer Res. 2006 Aug 15;12(16):4882-7 [16914576] J Clin Oncol. 2007 Mar 20;25(9):1082-8 [17261851] J Clin Oncol. 2007 Aug 10;25(23):3421-7 [17606971] J Clin Oncol. 2007 Aug 10;25(23):3415-20 [17606972] J Clin Oncol. 2007 Aug 10;25(23):3448-55 [17606973] J Clin Oncol. 2007 Aug 10;25(23):3407-14 [17606974] J Clin Oncol. 2007 Aug 10;25(23):3399-406 [17606975] Cancer Chemother Pharmacol. 2008 Apr;61(5):751-8 [17594093] J Clin Oncol. 2003 May 1;21(9):1866-73 [12721265] Clin Cancer Res. 2004 Feb 15;10(4):1289-98 [14977827] J Clin Oncol. 2004 May 15;22(10):2015-25 [15143095] Cancer Res. 1995 Jun 1;55(11):2325-33 [7757983] J Antibiot (Tokyo). 1996 Jun;49(6):560-3 [8698639] J Clin Oncol. 1997 Apr;15(4):1538-43 [9193350] J Natl Cancer Inst. 1997 Aug 6;89(15):1138-47 [9262252] J Clin Oncol. 2005 Apr 20;23(12):2726-34 [15837987] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1200/JCO.2008.17.6644 ER - TY - JOUR T1 - Alterations in phosphorylated cyclic adenosine monophosphate response element of binding protein activity: a pathway for fetal alcohol syndrome-related neurotoxicity. AN - 66872157; 19110231 AB - Fetal alcohol syndrome (FAS) is the leading cause of a spectrum of preventable nongenetic learning and behavioral disorders. In adult (FAS) mice, we measured phosphorylated cyclic adenosine monophosphate response element of binding protein (pCREB) staining in hippocampal subregions to evaluate a possible mechanism underlying FAS learning deficits. Pregnant C57BL6/J mice were treated on gestational day 8 with alcohol or control (saline). After learning assessment, the offspring were perfused for immunohistochemistry and brain sections probed using SER 133 pCREB antibody. Relative staining density was assessed using National Institutes of Health Image software. Statistical analysis included analysis of variance with P < .05 considered significant. In all hippocampal subregions, pCREB staining was greater in the control animals than in the alcohol-treated group (P < or = .0001). In utero alcohol exposure decreased pCREB activity in hippocampal subregions of adult mice. The dentate gyrus had the most robust cumulative decrease in pCREB staining, suggesting FAS adult learning deficits may correlate to enhanced dentate gyrus neurodegeneration. JF - American journal of obstetrics and gynecology AU - Roberson, Robin AU - Cameroni, Irene AU - Toso, Laura AU - Abebe, Daniel AU - Bissel, Stephanie AU - Spong, Catherine Y AD - Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20895, USA. robersor@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 193.e1 EP - 5 VL - 200 IS - 2 KW - Carrier Proteins KW - 0 KW - Cyclic AMP KW - E0399OZS9N KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Dentate Gyrus -- metabolism KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Neurotoxicity Syndromes -- metabolism KW - Immunohistochemistry KW - Female KW - Pregnancy KW - Carrier Proteins -- metabolism KW - Fetal Alcohol Spectrum Disorders -- metabolism KW - Hippocampus -- metabolism KW - Cyclic AMP -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66872157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Alterations+in+phosphorylated+cyclic+adenosine+monophosphate+response+element+of+binding+protein+activity%3A+a+pathway+for+fetal+alcohol+syndrome-related+neurotoxicity.&rft.au=Roberson%2C+Robin%3BCameroni%2C+Irene%3BToso%2C+Laura%3BAbebe%2C+Daniel%3BBissel%2C+Stephanie%3BSpong%2C+Catherine+Y&rft.aulast=Roberson&rft.aufirst=Robin&rft.date=2009-02-01&rft.volume=200&rft.issue=2&rft.spage=193.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/10.1016%2Fj.ajog.2008.08.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2004 Jan 14;24(2):319-28 [14724230] Biosci Rep. 2001 Oct;21(5):565-611 [12168768] Neuron. 2002 Apr 25;34(3):371-85 [11988169] Nat Genet. 2002 May;31(1):47-54 [11967539] J Neurosci. 2002 May 1;22(9):3673-82 [11978843] J Neurosci. 2002 Feb 1;22(3):619-23 [11826089] Semin Clin Neuropsychiatry. 2000 Jul;5(3):177-90 [11291013] Semin Neonatol. 2000 Aug;5(3):243-54 [10956449] Nat Neurosci. 2000 Jun;3(6):545-50 [10816309] Nature. 1999 Nov 25;402(6760):421-5 [10586883] J Neurochem. 1999 Nov;73(5):1836-42 [10537041] Front Biosci. 1997 Jun 15;2:d309-16 [9206984] Alcohol. 2001 Jan;23(1):49-57 [11282452] Lancet. 1973 Nov 3;302(7836):999-1001 [4127281] Nature. 1982 Jun 24;297(5868):681-3 [7088155] Behav Neurosci. 1983 Dec;97(6):873-89 [6651962] Brain Res. 1984 Aug 13;308(2):325-32 [6541071] Brain Res. 1988 Jun 14;452(1-2):57-65 [3401749] Am J Med Genet. 1988 Nov;31(3):505-12 [3067574] Science. 1989 Mar 31;243(4899):1721-4 [2467382] J Neurosci Methods. 1989 Sep;29(3):251-9 [2477650] Behav Neural Biol. 1993 Jul;60(1):9-26 [8216164] Annu Rev Neurosci. 1994;17:341-71 [8210179] Neuron. 1996 May;16(5):973-82 [8630255] Alcohol Clin Exp Res. 1996 Sep;20(6):1088-93 [8892532] Cell. 1996 Dec 27;87(7):1203-14 [8980227] Epidemiology. 1997 Sep;8(5):509-14 [9270952] Teratology. 1997 Nov;56(5):317-26 [9451756] Am J Psychiatry. 1998 Apr;155(4):552-4 [9546004] Learn Mem. 1998 Jul-Aug;5(3):220-30 [10454366] Alcohol Clin Exp Res. 2005 Apr;29(4):672-82 [15834234] Am J Obstet Gynecol. 2005 Sep;193(3 Pt 1):825-9 [16150281] Am J Obstet Gynecol. 2005 Oct;193(4):1534-9 [16202752] Alcohol Clin Exp Res. 2005 Nov;29(11):2053-62 [16340464] Hippocampus. 2006;16(3):305-11 [16425237] J Pediatr. 2007 Feb;150(2):175-9, 179.e1 [17236896] Exp Neurol. 2007 Mar;204(1):400-10 [17270176] Learn Mem. 2007 Mar;14(3):195-9 [17351144] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ajog.2008.08.054 ER - TY - JOUR T1 - Intakes of red meat, processed meat, and meat mutagens increase lung cancer risk. AN - 66864946; 19141639 AB - Red and processed meat intake may increase lung cancer risk. However, the epidemiologic evidence is inconsistent and few studies have evaluated the role of meat mutagens formed during high cooking temperatures. We investigated the association of red meat, processed meat, and meat mutagen intake with lung cancer risk in Environment And Genetics in Lung cancer Etiology, a population-based case-control study. Primary lung cancer cases (n = 2,101) were recruited from 13 hospitals within the Lombardy region of Italy examining approximately 80% of the cases from the area. Noncancer population controls (n = 2,120), matched to cases on gender, residence, and age, were randomly selected from the same catchment area. Diet was assessed in 1,903 cases and 2,073 controls and used in conjunction with a meat mutagen database to estimate intake of heterocyclic amines (HCA) and benzo(a)pyrene (BaP). Multivariable odds ratios (OR) and 95% confidence intervals (95% CI) for sex-specific tertiles of intake were calculated using unconditional logistic regression. Red and processed meat were positively associated with lung cancer risk (highest-versus-lowest tertile: OR, 1.8; 95% CI, 1.5-2.2; P trend < 0.001 and OR, 1.7; 95% CI, 1.4-2.1; P trend < 0.001, respectively); the risks were strongest among never smokers (OR, 2.4; 95% CI, 1.4-4.0; P trend = 0.001 and OR, 2.5; 95% CI, 1.5-4.2; P trend = 0.001, respectively). HCAs and BaP were significantly associated with increased risk of lung cancer. When separated by histology, significant positive associations for both meat groups were restricted to adenocarcinoma and squamous cell carcinoma but not small cell carcinoma of the lung. In summary, red meat, processed meat, and meat mutagens were independently associated with increased risk of lung cancer. JF - Cancer research AU - Lam, Tram Kim AU - Cross, Amanda J AU - Consonni, Dario AU - Randi, Giorgia AU - Bagnardi, Vincenzo AU - Bertazzi, Pier Alberto AU - Caporaso, Neil E AU - Sinha, Rashmi AU - Subar, Amy F AU - Landi, Maria Teresa AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, NIH, Department of Health and Human Services, [corrected] Bethesda, Maryland 20892-7236, USA. Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 SP - 932 EP - 939 VL - 69 IS - 3 KW - Imidazoles KW - 0 KW - Mutagens KW - Quinoxalines KW - 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline KW - 77500-04-0 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - 3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine KW - YRA7G7WU6P KW - Index Medicus KW - Animals KW - Chickens KW - Cattle KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Italy -- epidemiology KW - Male KW - Female KW - Meat KW - Lung Neoplasms -- epidemiology KW - Meat Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66864946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Intakes+of+red+meat%2C+processed+meat%2C+and+meat+mutagens+increase+lung+cancer+risk.&rft.au=Lam%2C+Tram+Kim%3BCross%2C+Amanda+J%3BConsonni%2C+Dario%3BRandi%2C+Giorgia%3BBagnardi%2C+Vincenzo%3BBertazzi%2C+Pier+Alberto%3BCaporaso%2C+Neil+E%3BSinha%2C+Rashmi%3BSubar%2C+Amy+F%3BLandi%2C+Maria+Teresa&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2009-02-01&rft.volume=69&rft.issue=3&rft.spage=932&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-3162 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Causes Control. 2000 May;11(5):419-31 [10877335] BMC Public Health. 2008;8:203 [18538025] Cancer Res. 2000 Jul 15;60(14):3753-6 [10919646] Lung Cancer. 2001 Oct;34(1):37-46 [11557111] Jpn J Cancer Res. 2001 Dec;92(12):1259-69 [11749690] Lung Cancer. 2002 Jan;35(1):43-51 [11750712] Cancer Detect Prev. 2002;26(2):129-38 [12102147] Int J Cancer. 2002 Aug 20;100(6):706-13 [12209611] Drug Metab Rev. 2002 Aug;34(3):667-76 [12214673] Toxicology. 2002 Nov 15;180(2):121-37 [12324189] Lung Cancer. 2002 Oct;38(1):1-7 [12367786] Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):987-92 [12376497] Public Health Nutr. 2002 Dec;5(6B):1243-58 [12639230] Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6 [12835281] Environ Mol Mutagen. 2004;44(1):44-55 [15199546] Semin Cancer Biol. 2004 Dec;14(6):473-86 [15489140] Mutat Res. 1975 Dec;31(6):347-64 [768755] Int J Cancer. 1981;27(4):471-4 [7275353] Cancer Res. 1982 Dec;42(12):4875-917 [6814745] Am J Epidemiol. 1991 Apr 1;133(7):683-93 [2018023] Epidemiology. 1992 Jul;3(4):288-99 [1637893] Chem Res Toxicol. 1992 Sep-Oct;5(5):691-7 [1446011] Cancer Causes Control. 1994 Sep;5(5):395-400 [7999960] Carcinogenesis. 1994 Dec;15(12):2757-61 [8001231] Food Chem Toxicol. 1995 Jul;33(7):545-51 [7628789] Int J Epidemiol. 1996 Feb;25(1):32-9 [8666501] Lung Cancer. 1996 Jun;14(2-3):195-205 [8794403] Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):679-82 [8877057] Eur J Cancer Prev. 1996 Sep;5 Suppl 1:109-14 [8972304] Cancer Detect Prev. 1997;21(5):391-405 [9307842] Cancer Causes Control. 1997 Nov;8(6):913-21 [9427434] Nutr Rev. 1998 Apr;56(4 Pt 1):95-105 [9584494] Cancer Causes Control. 1998 Dec;9(6):621-30 [10189048] Carcinogenesis. 1999 Mar;20(3):353-68 [10190547] Mutat Res. 1999 Jul 15;443(1-2):129-38 [10415436] Cancer Lett. 1999 Sep 1;143(2):189-94 [10503902] Int J Epidemiol. 2004 Dec;33(6):1382-6 [15333618] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Chem Res Toxicol. 2005 Sep;18(9):1471-8 [16167840] Epidemiology. 2005 Nov;16(6):772-9 [16222167] Br J Nutr. 2006 Aug;96 Suppl 1:S42-5 [16923250] Am J Clin Nutr. 2006 Nov;84(5):1177-83 [17093172] Carcinogenesis. 2007 Mar;28(3):732-7 [17052995] PLoS Med. 2007 Dec;4(12):e325 [18076279] PLoS Med. 2007 Dec;4(12):e345 [18076281] Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):80-7 [18199713] Cancer Causes Control. 2008 Aug;19(6):649-56 [18264785] Erratum In: Cancer Res. 2009 Apr 1;69(7):3240 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-3162 ER - TY - JOUR T1 - Tamoxifen induces expression of immune response-related genes in cultured normal human mammary epithelial cells. AN - 66864022; 19155303 AB - Use of tamoxifen is associated with a 50% reduction in breast cancer incidence and an increase in endometrial cancer incidence. Here, we documented tamoxifen-induced gene expression changes in cultured normal human mammary epithelial cells (strains 5, 16, and 40), established from tissue taken at reduction mammoplasty from three individuals. Cells exposed to 0, 10, or 50 micromol/L of tamoxifen for 48 hours were evaluated for (E)-alpha-(deoxyguanosine-N(2)-yl)-tamoxifen (dG-N(2)-TAM) adduct formation using TAM-DNA (DNA modified with dG-N(2)-TAM) chemiluminescence immunoassay, gene expression changes using National Cancer Institute DNA-oligonucleotide microarray, and real-time PCR. At 48 hours, cells exposed to 10 and 50 micromol/L of tamoxifen were 85.6% and 48.4% viable, respectively, and there were no measurable dG-N(2)-TAM adducts. For microarrays, cells were exposed to 10 micromol/L of tamoxifen and genes with expression changes of >3-fold were as follows: 13 genes up-regulated and 1 down-regulated for strain 16; 17 genes up-regulated for strain 5, and 11 genes up-regulated for strain 40. Interferon-inducible genes (IFITM1, IFIT1, MXI, and GIP3), and a potassium ion channel (KCNJ1) were up-regulated in all three strains. No significant expression changes were found for genes related to estrogen or xenobiotic metabolism. Real-time PCR revealed the up-regulation of IFNA1 and confirmed the tamoxifen-induced up-regulation of the five other genes identified by microarray, with the exception of GIP3 and MX1, which were not up-regulated in strain 40. Induction of IFN-related genes in the three normal human mammary epithelial cell strains suggests that, in addition to hormonal effects, tamoxifen exposure may enhance immune response in normal breast tissue. JF - Cancer research AU - Schild-Hay, Laura J AU - Leil, Tarek A AU - Divi, Rao L AU - Olivero, Ofelia A AU - Weston, Ainsley AU - Poirier, Miriam C AD - Carcinogen-DNA Interactions Section, LCBG, CCR, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 SP - 1150 EP - 1155 VL - 69 IS - 3 KW - DNA Adducts KW - 0 KW - Receptors, Estrogen KW - Tamoxifen KW - 094ZI81Y45 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - DNA Adducts -- biosynthesis KW - Epithelial Cells -- drug effects KW - Receptors, Estrogen -- biosynthesis KW - Cells, Cultured KW - Humans KW - DNA -- metabolism KW - Epithelial Cells -- immunology KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - Female KW - DNA -- drug effects KW - Tamoxifen -- pharmacology KW - Mammary Glands, Human -- cytology KW - Up-Regulation -- drug effects KW - Mammary Glands, Human -- metabolism KW - Up-Regulation -- immunology KW - Mammary Glands, Human -- drug effects KW - Mammary Glands, Human -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66864022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Tamoxifen+induces+expression+of+immune+response-related+genes+in+cultured+normal+human+mammary+epithelial+cells.&rft.au=Schild-Hay%2C+Laura+J%3BLeil%2C+Tarek+A%3BDivi%2C+Rao+L%3BOlivero%2C+Ofelia+A%3BWeston%2C+Ainsley%3BPoirier%2C+Miriam+C&rft.aulast=Schild-Hay&rft.aufirst=Laura&rft.date=2009-02-01&rft.volume=69&rft.issue=3&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-2806 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 2000 Apr 17;1496(2-3):196-206 [10771088] J Biol Chem. 2007 Jul 13;282(28):20059-63 [17502367] Nature. 2000 Aug 17;406(6797):747-52 [10963602] Cancer Res. 2001 May 15;61(10):3925-31 [11358807] Carcinogenesis. 2001 Jun;22(6):839-49 [11375888] Int J Cancer. 2002 Jul 20;100(3):337-41 [12115550] Cancer Treat Rev. 2002 Aug;28(4):165-80 [12363457] Int J Gynecol Cancer. 2002 Sep-Oct;12(5):496-500 [12366669] Lancet. 2003 Jan 25;361(9354):296-300 [12559863] Mol Cancer Res. 2003 Feb;1(4):300-11 [12612058] Curr Drug Metab. 2003 Jun;4(3):223-39 [12769667] Mutagenesis. 2003 Jul;18(4):395-9 [12840114] Expert Opin Drug Saf. 2002 Sep;1(3):253-67 [12904141] Endocr Relat Cancer. 2003 Sep;10(3):347-57 [14503912] Cancer Res. 2003 Dec 1;63(23):8461-5 [14679010] J Natl Cancer Inst. 2004 Jan 7;96(1):70-4 [14709741] J Natl Cancer Inst. 2004 Jul 21;96(14):1099-104 [15265972] Lancet. 1992 Jan 4;339(8784):1-15 [1345950] Cancer Res. 1993 Sep 1;53(17):3919-24 [8358718] Cancer Res. 1996 Oct 1;56(19):4374-7 [8813128] Mol Cell Biochem. 1997 Feb;167(1-2):169-77 [9059994] Int J Cancer. 1997 Jun 11;71(6):1103-8 [9185717] J Interferon Cytokine Res. 1997 Nov;17(11):681-93 [9402106] Carcinogenesis. 1999 Feb;20(2):339-42 [10069474] Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9212-7 [10430922] Oncogene. 2004 Nov 18;23(54):8743-55 [15467738] Chem Res Toxicol. 2004 Dec;17(12):1577-83 [15606132] Mol Cancer Ther. 2005 Jan;4(1):151-68 [15657362] J Mol Endocrinol. 2005 Feb;34(1):61-75 [15691878] Cancer Chemother Pharmacol. 2005 Apr;55(4):343-6 [15592834] Cancer Lett. 2005 Apr 28;221(2):213-24 [15808407] Mol Cancer Res. 2005 Apr;3(4):203-18 [15831674] Mutagenesis. 2005 Mar;20(2):115-24 [15755801] Mutagenesis. 2005 Jul;20(4):297-303 [15928012] Eur J Gynaecol Oncol. 2005;26(5):501-4 [16285565] Cancer Res. 2006 Jul 15;66(14):7334-40 [16849584] Crit Rev Oncol Hematol. 2007 Mar;61(3):187-94 [17088071] Expert Rev Anticancer Ther. 2007 May;7(5):627-34 [17492927] Biochimie. 2007 Jun-Jul;89(6-7):723-8 [17451861] Biochimie. 2007 Jun-Jul;89(6-7):713-8 [17544197] Carcinogenesis. 2000 Aug;21(8):1461-7 [10910945] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-2806 ER - TY - JOUR T1 - Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. AN - 66858074; 18984744 AB - The aim of this study was to find an effective treatment for the genetic form of diabetes that is present in some Huntington's disease patients and in Huntington's disease mouse models. Huntington's disease is a neurodegenerative disorder caused by a polyglutamine expansion within the huntingtin protein. Huntington's disease patients exhibit neuronal dysfunction/degeneration, chorea, and progressive weight loss. Additionally, they suffer from abnormalities in energy metabolism affecting both the brain and periphery. Similarly to Huntington's disease patients, mice expressing the mutated human huntingtin protein also exhibit neurodegenerative changes, motor dysfunction, perturbed energy metabolism, and elevated blood glucose levels. Huntington's disease mice were treated with an FDA-approved antidiabetic glucagon-like peptide 1 receptor agonist, exendin-4 (Ex-4), to test whether euglycemia could be achieved, whether pancreatic dysfunction could be alleviated, and whether the mice showed any neurological benefit. Blood glucose and insulin levels and various appetite hormone concentrations were measured during the study. Additionally, motor performance and life span were quantified and mutant huntingtin (mhtt) aggregates were measured in both the pancreas and brain. Ex-4 treatment ameliorated abnormalities in peripheral glucose regulation and suppressed cellular pathology in both brain and pancreas in a mouse model of Huntington's disease. The treatment also improved motor function and extended the survival time of the Huntington's disease mice. These clinical improvements were correlated with reduced accumulation of mhtt protein aggregates in both islet and brain cells. Targeting both peripheral and neuronal deficits, Ex-4 is an attractive agent for therapeutic intervention in Huntington's disease patients suffering from diabetes. JF - Diabetes AU - Martin, Bronwen AU - Golden, Erin AU - Carlson, Olga D AU - Pistell, Paul AU - Zhou, Jie AU - Kim, Wook AU - Frank, Brittany P AU - Thomas, Sam AU - Chadwick, Wayne A AU - Greig, Nigel H AU - Bates, Gillian P AU - Sathasivam, Kirupa AU - Bernier, Michel AU - Maudsley, Stuart AU - Mattson, Mark P AU - Egan, Josephine M AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 318 EP - 328 VL - 58 IS - 2 KW - Adipokines KW - 0 KW - Blood Glucose KW - Ghrelin KW - Insulin KW - Peptides KW - Venoms KW - exenatide KW - 9P1872D4OL KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Blotting, Western KW - Survival Rate KW - Ghrelin -- blood KW - Insulin -- blood KW - Adipokines -- blood KW - Enzyme-Linked Immunosorbent Assay KW - Disease Models, Animal KW - Mice KW - Radioimmunoassay KW - Immunohistochemistry KW - Male KW - Pancreas -- pathology KW - Huntington Disease -- blood KW - Venoms -- therapeutic use KW - Brain -- pathology KW - Brain -- drug effects KW - Blood Glucose -- drug effects KW - Huntington Disease -- drug therapy KW - Pancreas -- drug effects KW - Huntington Disease -- mortality KW - Peptides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66858074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Exendin-4+improves+glycemic+control%2C+ameliorates+brain+and+pancreatic+pathologies%2C+and+extends+survival+in+a+mouse+model+of+Huntington%27s+disease.&rft.au=Martin%2C+Bronwen%3BGolden%2C+Erin%3BCarlson%2C+Olga+D%3BPistell%2C+Paul%3BZhou%2C+Jie%3BKim%2C+Wook%3BFrank%2C+Brittany+P%3BThomas%2C+Sam%3BChadwick%2C+Wayne+A%3BGreig%2C+Nigel+H%3BBates%2C+Gillian+P%3BSathasivam%2C+Kirupa%3BBernier%2C+Michel%3BMaudsley%2C+Stuart%3BMattson%2C+Mark+P%3BEgan%2C+Josephine+M&rft.aulast=Martin&rft.aufirst=Bronwen&rft.date=2009-02-01&rft.volume=58&rft.issue=2&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=1939-327X&rft_id=info:doi/10.2337%2Fdb08-0799 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2009-01-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocrine. 2005 Jun;27(1):1-9 [16077164] Cell Metab. 2005 Jan;1(1):53-61 [16054044] Hepatology. 2006 Jan;43(1):173-81 [16374859] Eur J Neurosci. 2006 Aug;24(4):961-7 [16925587] Cell. 2006 Oct 6;127(1):59-69 [17018277] Neurosci Lett. 2007 Jan 10;411(2):98-103 [17110029] Diabetes. 2007 Jan;56(1):143-51 [17192476] Exp Neurol. 2007 Feb;203(2):293-301 [17125767] Pharmacol Ther. 2007 Mar;113(3):546-93 [17306374] Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2945-9 [17299049] Endocr J. 2007 Apr;54(2):221-6 [17264468] PLoS Genet. 2007 Aug;3(8):e135 [17708681] Histol Histopathol. 2008 Feb;23(2):237-50 [17999380] Rev Neurosci. 2007;18(3-4):223-51 [18019608] J Neurosci Res. 2008 Feb 1;86(2):326-38 [17803225] Diabet Med. 2008 Feb;25(2):152-6 [18201212] Int J Obes Relat Metab Disord. 2003 Mar;27(3):313-8 [12629557] J Biol Chem. 2000 Mar 31;275(13):9572-80 [10734107] Ann Neurol. 2000 Jul;48(1):72-6 [10894218] Trends Neurosci. 2000 Sep;23(9):387-92 [10941183] Recent Prog Horm Res. 2001;56:377-99 [11237222] J Neurosci. 2001 May 15;21(10):3639-45 [11331393] Neurobiol Dis. 2001 Jun;8(3):479-91 [11447996] Nature. 2001 Oct 25;413(6858):794-5 [11677594] Neurobiol Dis. 2001 Dec;8(6):1017-26 [11741397] J Clin Endocrinol Metab. 2002 Mar;87(3):1282-90 [11889200] Nat Neurosci. 2002 Jun;5(6):566-72 [12021765] Nat Med. 2002 Dec;8(12):1376-82 [12426561] Am J Physiol Endocrinol Metab. 2003 Jun;284(6):E1072-9 [12475750] Lancet. 2003 May 10;361(9369):1642-4 [12747895] Nat Med. 2003 Sep;9(9):1173-9 [12925848] Diabetes Care. 2003 Oct;26(10):2835-41 [14514588] Science. 2003 Dec 5;302(5651):1710-1 [14657487] EMBO Rep. 2004 Oct;5(10):958-63 [15459747] Eur J Endocrinol. 2004 Oct;151(4):451-5 [15476444] Clin Genet. 1985 Jan;27(1):62-7 [3156696] Nature. 1986 May 8-14;321(6066):168-71 [2422561] Ann Neurol. 1986 Sep;20(3):296-303 [2945510] Nat Genet. 1993 Aug;4(4):398-403 [8401589] J Neurol. 1993 Nov;241(1):31-6 [8138819] Ann Neurol. 1996 Mar;39(3):385-9 [8602759] Neuroscience. 1997 Feb;76(3):749-61 [9135048] Mol Cell Endocrinol. 1998 Jun 25;141(1-2):179-86 [9723898] Hum Mol Genet. 1999 Mar;8(3):397-407 [9949199] Diabetes. 1999 Mar;48(3):649-51 [10078572] Hum Mol Genet. 1999 May;8(5):813-22 [10196370] Diabetes. 1999 May;48(5):1045-53 [10331409] Hum Mol Genet. 2005 Mar 1;14(5):565-74 [15649949] Am J Clin Nutr. 2005 Jun;81(6):1335-41 [15941884] Exp Brain Res. 2005 Oct;166(2):220-9 [16034568] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2337/db08-0799 ER - TY - JOUR T1 - 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. AN - 66853399; 18936140 AB - 7-Ketocholesterol is a highly toxic oxysterol found in abundance in atherosclerotic plaques and is believed to play a critical role in atherosclerosis. The purpose of this study was to identify and localize 7-ketocholesterol (7kCh) in the primate retina and to examine the potential consequences of its presence in oxidized lipid deposits in the retina. Unsterified 7kCh was identified and quantified by high-performance liquid chromatography-mass spectrometry. Localization of 7kCh was performed by immunohistochemistry. VEGF induction was determined by qRT-PCR. Cell viability was determined by measuring cellular dehydrogenase activity. Analyses were performed using ARPE19 and human vascular endothelial cells (HMVECs). 7-Ketocholesterol is localized mainly to deposits in the choriocapillaris and Bruch's membrane and on the surfaces of vascular endothelial cells of the neural retina. RPE/choriocapillaris regions contained approximately four times more 7kCh than the neural retina. In ARPE19 cells and HMVECs, oxidized LDL and 7kCh induced VEGF 8- to 10-fold above controls. Hypoxia inducible factor (HIF)-1alpha levels did not increase as a result of 7kCh treatment, suggesting an HIF-independent induction pathway. Cholesterol sulfate, a liver X receptor (LXR) antagonist, had marked attenuation of the 7kCh-mediated VEGF induction. LXR-specific siRNAs also reduced VEGF induction. Inhibition of NF-kappaB with BAY 11-7082 reduced IL-8 but not VEGF induction. The location of 7-kCh in the retina and its induction of VEGF in cultured RPE cells and HMVECs suggest it may play a critical role in choroidal neovascularization. The pathway for VEGF induction seems to be independent of HIF-1alpha and NF-kappaB but seems to be partially regulated by LXRs. JF - Investigative ophthalmology & visual science AU - Moreira, Ernesto F AU - Larrayoz, Ignacio M AU - Lee, Jung Wha AU - Rodríguez, Ignacio R AD - Section on Mechanisms of Retinal Diseases, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 523 EP - 532 VL - 50 IS - 2 KW - Cholesterol Esters KW - 0 KW - DNA-Binding Proteins KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Ketocholesterols KW - Lipoproteins, LDL KW - Liver X Receptors KW - NF-kappa B KW - Orphan Nuclear Receptors KW - RNA, Messenger KW - RNA, Small Interfering KW - Receptors, Cytoplasmic and Nuclear KW - VEGFA protein, human KW - Vascular Endothelial Growth Factor A KW - oxidized low density lipoprotein KW - cholesteryl sulfate KW - KU576NT9O9 KW - 7-ketocholesterol KW - O7676FE78M KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Endothelium, Vascular -- metabolism KW - Humans KW - DNA-Binding Proteins -- genetics KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Chromatography, High Pressure Liquid KW - Cell Survival KW - Receptors, Cytoplasmic and Nuclear -- antagonists & inhibitors KW - Endothelium, Vascular -- drug effects KW - RNA, Messenger -- metabolism KW - Cholesterol Esters -- metabolism KW - RNA, Small Interfering -- pharmacology KW - Enzyme-Linked Immunosorbent Assay KW - Macaca mulatta KW - DNA-Binding Proteins -- antagonists & inhibitors KW - Lipoproteins, LDL -- pharmacology KW - Immunoenzyme Techniques KW - Cell Line KW - NF-kappa B -- metabolism KW - Retina -- metabolism KW - Vascular Endothelial Growth Factor A -- biosynthesis KW - Ketocholesterols -- pharmacology KW - Choroidal Neovascularization -- metabolism KW - Retinal Pigment Epithelium -- metabolism KW - Retinal Pigment Epithelium -- drug effects KW - Retina -- pathology KW - Ketocholesterols -- metabolism KW - Bruch Membrane -- metabolism KW - Vascular Endothelial Growth Factor A -- genetics KW - Lipid Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66853399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=7-Ketocholesterol+is+present+in+lipid+deposits+in+the+primate+retina%3A+potential+implication+in+the+induction+of+VEGF+and+CNV+formation.&rft.au=Moreira%2C+Ernesto+F%3BLarrayoz%2C+Ignacio+M%3BLee%2C+Jung+Wha%3BRodr%C3%ADguez%2C+Ignacio+R&rft.aulast=Moreira&rft.aufirst=Ernesto&rft.date=2009-02-01&rft.volume=50&rft.issue=2&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=1552-5783&rft_id=info:doi/10.1167%2Fiovs.08-2373 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2009-01-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2001 Oct 5;107(1):43-54 [11595184] Steroids. 2001 Jun;66(6):473-9 [11182136] Jpn J Pharmacol. 2002 May;89(1):81-4 [12083747] Vascul Pharmacol. 2002 Apr;38(4):239-48 [12449020] J Cell Sci. 2003 Feb 15;116(Pt 4):665-74 [12538767] Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1753-9 [12657618] J Biol Chem. 2004 Mar 12;279(11):9905-11 [14699103] Arterioscler Thromb Vasc Biol. 2004 May;24(5):949-54 [15001454] Biotechniques. 2004 Jun;36(6):952-4, 956, 958 [15211745] Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2822-9 [15277509] Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2830-7 [15277510] Endocr Rev. 2004 Aug;25(4):581-611 [15294883] Biochem Biophys Res Commun. 2004 Sep 3;321(4):788-94 [15358096] Steroids. 1985 Mar-Apr;45(3-4):317-23 [3834655] J Photochem Photobiol B. 1992 Apr 30;13(2):105-18 [1506985] Photochem Photobiol. 1992 Jul;56(1):1-8 [1508976] Circ Res. 1995 Sep;77(3):638-43 [7641334] Chem Phys Lipids. 1995 Nov 17;78(2):119-28 [8565112] J Lipid Res. 1996 Feb;37(2):320-35 [9026530] Nature. 1996 Oct 24;383(6602):728-31 [8878485] J Biol Chem. 1996 Nov 1;271(44):27450-5 [8910326] Arterioscler Thromb Vasc Biol. 1998 Jul;18(7):1188-96 [9672081] Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):266-71 [9874807] Int J Biochem Cell Biol. 1999 Mar-Apr;31(3-4):369-75 [10224662] J Clin Invest. 1955 Sep;34(9):1345-53 [13252080] Can J Biochem Physiol. 1959 Aug;37(8):911-7 [13671378] Cardiovasc Res. 2005 Feb 15;65(3):564-73 [15664382] Vasc Med. 2005 May;10(2):109-19 [16013195] Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):375-80 [16677084] Mol Vis. 2006;12:1306-18 [17110914] Free Radic Res. 2007 Mar;41(3):260-6 [17364953] Curr Eye Res. 2007 Mar;32(3):271-80 [17453947] Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11026-31 [17578916] Circulation. 2007 Sep 11;116(11):1226-33 [17709641] Clin Cancer Res. 2007 Oct 1;13(19):5670-4 [17908955] Sci STKE. 2007 Oct 9;2007(407):cm8 [17925579] Cancer Res. 2007 Nov 15;67(22):10823-30 [18006827] Biochem J. 2008 Jan 1;409(1):19-26 [18062771] Mol Immunol. 2008 May;45(9):2446-54 [18258304] J Atheroscler Thromb. 1998;5(2):66-75 [10855560] J Immunol. 2000 Jul 15;165(2):1013-21 [10878378] Methods Enzymol. 2000;319:85-100 [10907502] Cancer Res. 2000 Aug 1;60(15):4010-5 [10945599] Invest Ophthalmol Vis Sci. 2001 Jan;42(1):265-74 [11133878] Atherosclerosis. 2001 Dec;159(2):325-32 [11730812] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1167/iovs.08-2373 ER - TY - JOUR T1 - Medical response to a radiologic/nuclear event: integrated plan from the Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services. AN - 66849472; 18387707 AB - The end of the Cold War led to a reduced concern for a major nuclear event. However, the current threats from terrorism make a radiologic (dispersal or use of radioactive material) or nuclear (improvised nuclear device) event a possibility. The specter and enormousness of the catastrophe resulting from a state-sponsored nuclear attack and a sense of nihilism about the effectiveness of a response were such that there had been limited civilian medical response planning. Although the consequences of a radiologic dispersal device are substantial, and the detonation of a modest-sized (10 kiloton) improvised nuclear device is catastrophic, it is both possible and imperative that a medical response be planned. To meet this need, the Office of the Assistant Secretary for Preparedness and Response in the Department of Health and Human Services, in collaboration within government and with nongovernment partners, has developed a scientifically based comprehensive planning framework and Web-based "just-in-time" medical response information called Radiation Event Medical Management (available at http://www.remm.nlm.gov). The response plan includes (1) underpinnings from basic radiation biology, (2) tailored medical responses, (3) delivery of medical countermeasures for postevent mitigation and treatment, (4) referral to expert centers for acute treatment, and (5) long-term follow-up. Although continuing to evolve and increase in scope and capacity, current response planning is sufficiently mature that planners and responders should be aware of the basic premises, tools, and resources available. An effective response will require coordination, communication, and cooperation at an unprecedented level. The logic behind and components of this response are presented to allow for active collaboration among emergency planners and responders and federal, state, local, and tribal governments. JF - Annals of emergency medicine AU - Coleman, C Norman AU - Hrdina, Chad AU - Bader, Judith L AU - Norwood, Ann AU - Hayhurst, Robert AU - Forsha, Joseph AU - Yeskey, Kevin AU - Knebel, Ann AD - Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA. ccoleman@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 213 EP - 222 VL - 53 IS - 2 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Acute Radiation Syndrome KW - Transportation KW - Triage KW - Humans KW - Government Agencies KW - Mass Casualty Incidents KW - Algorithms KW - United States Dept. of Health and Human Services KW - Disaster Planning -- organization & administration KW - Terrorism KW - Civil Defense -- organization & administration KW - Radioactive Hazard Release KW - Nuclear Warfare KW - Disasters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66849472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+emergency+medicine&rft.atitle=Medical+response+to+a+radiologic%2Fnuclear+event%3A+integrated+plan+from+the+Office+of+the+Assistant+Secretary+for+Preparedness+and+Response%2C+Department+of+Health+and+Human+Services.&rft.au=Coleman%2C+C+Norman%3BHrdina%2C+Chad%3BBader%2C+Judith+L%3BNorwood%2C+Ann%3BHayhurst%2C+Robert%3BForsha%2C+Joseph%3BYeskey%2C+Kevin%3BKnebel%2C+Ann&rft.aulast=Coleman&rft.aufirst=C&rft.date=2009-02-01&rft.volume=53&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Annals+of+emergency+medicine&rft.issn=1097-6760&rft_id=info:doi/10.1016%2Fj.annemergmed.2007.12.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Ann Emerg Med. 2009 Feb;53(2):223-5 [18387705] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.annemergmed.2007.12.021 ER - TY - JOUR T1 - Effect of dose volume on the toxicokinetics of acrylamide and its metabolites and 2-deoxy-D-glucose. AN - 66841736; 19022940 AB - Acrylamide (AA) is a known mutagen and animal carcinogen. Comparison of recent studies revealed significant quantitative differences in AA-induced germ cell mutagenicity. It was hypothesized that despite the administration of AA at similar doses, the discrepancy in the observed effects was most likely due to varying AA concentrations in the administered dosing solution. To test this hypothesis, AA was administered i.p. to mice at 50 mg/kg in a dose volume of 5 or 50 ml/kg, blood was collected at various time points, and AA and its metabolites were quantitated. Changes in dose volume resulted in significant differences in the toxicokinetics of AA and its metabolites and suggested that increased C(max) of AA led to increased metabolism. This theory, in conjunction with the fact that higher levels of AA-derived radioactivity were detected in the testes, may explain the greater toxicity of a 50 mg/kg dose when administered in 5 versus 50 ml/kg. The impact of dose volume on the toxicokinetics of 2-deoxy-d-glucose (DG), a nonreactive, nonmetabolizable substance, was also investigated. The areas under the curve for DG were not different for the two dose volumes; however, C(max) for the more concentrated dose was significantly higher. In conclusion, current studies show that the toxicokinetics of an administered xenobiotic and its metabolites is influenced by the concentration of the parent chemical in the dosing solution. Therefore, it is important to consider the concentration of an administered xenobiotic in the dosing solution because it may affect its toxicokinetics and metabolism and subsequently affect the biological effects of the administered chemical. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Ghanayem, Burhan I AU - Bai, Re AU - Burka, Leo T AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Ghanayem@niehs.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 259 EP - 263 VL - 37 IS - 2 KW - Carcinogens KW - 0 KW - Epoxy Compounds KW - Mutagens KW - Acrylamide KW - 20R035KLCI KW - Deoxyglucose KW - 9G2MP84A8W KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Administration, Oral KW - Spectrometry, Mass, Electrospray Ionization KW - Animals KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - Mutagens -- pharmacokinetics KW - Mice KW - Glucose -- pharmacokinetics KW - Male KW - Carcinogens -- metabolism KW - Carcinogens -- pharmacokinetics KW - Carcinogens -- toxicity KW - Acrylamide -- metabolism KW - Deoxyglucose -- pharmacokinetics KW - Deoxyglucose -- toxicity KW - Acrylamide -- pharmacokinetics KW - Acrylamide -- toxicity KW - Deoxyglucose -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66841736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Effect+of+dose+volume+on+the+toxicokinetics+of+acrylamide+and+its+metabolites+and+2-deoxy-D-glucose.&rft.au=Ghanayem%2C+Burhan+I%3BBai%2C+Re%3BBurka%2C+Leo+T&rft.aulast=Ghanayem&rft.aufirst=Burhan&rft.date=2009-02-01&rft.volume=37&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.108.024265 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-14 N1 - Date created - 2009-01-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Chem Res Toxicol. 2003 Oct;16(10):1328-37 [14565774] Toxicol Appl Pharmacol. 2003 May 1;188(3):135-53 [12729714] Cytogenet Genome Res. 2004;104(1-4):271-6 [15162050] J Natl Cancer Inst. 2004 Jul 7;96(13):1023-9 [15240786] Chem Res Toxicol. 1992 Jan-Feb;5(1):81-9 [1581543] IARC Monogr Eval Carcinog Risks Hum. 1994;60:389-433 [7869577] Chem Biol Interact. 1999 Jul 1;121(2):199-207 [10418964] Biol Reprod. 2005 Jan;72(1):157-63 [15355880] Mutat Res. 2005 Oct 15;578(1-2):284-97 [15982677] Toxicol Sci. 2005 Dec;88(2):311-8 [16141435] Environ Mol Mutagen. 2006 Jan;47(1):6-17 [15957192] Toxicol Sci. 2006 Oct;93(2):256-67 [16870689] Carcinogenesis. 2007 Mar;28(3):519-28 [17234719] Chem Res Toxicol. 1999 Nov;12(11):1110-6 [10563837] Mutagenesis. 2000 Mar;15(2):133-6 [10719038] J Agric Food Chem. 2002 Aug 14;50(17):4998-5006 [12166997] J Agric Food Chem. 2003 Jul 30;51(16):4504-26 [14705871] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/dmd.108.024265 ER - TY - JOUR T1 - Novel biomarkers of prenatal methamphetamine exposure in human meconium. AN - 66839228; 19125148 AB - Meconium analysis can detect fetal exposure to drugs taken by the mother during pregnancy. Methamphetamine (MAMP) and amphetamine (AMP) have previously been observed in meconium of MAMP-exposed neonates; the presence of other metabolites has not been investigated. Detection of such analytes may lead to more sensitive identification and thus improved medical treatment of affected infants. Forty-three MAMP-positive meconium specimens were analyzed for newly identified MAMP biomarkers, p-hydroxymethamphetamine, p-hydroxyamphetamine, and norephedrine. Due to MAMP adulteration in illicit ecstasy and to simultaneously monitor 3,4-methylenedioxymethamphetamine and MAMP prenatal exposure, 3,4-methylenedioxymethamphetamine, its metabolites, and related sympathomimetic amines were assayed. MAMP, AMP, and unconjugated p-hydroxymethamphetamine were the most prevalent and abundant analytes present in meconium; however, unconjugated p-hydroxyamphetamine and norephedrine also were identified. It is possible that one of these additional analytes could be important for predicting toxicity or maternal or neonatal outcome measures in fetuses exposed to MAMP at specific gestational ages or with different metabolic capabilities. Although these new biomarkers were present in lower concentrations than MAMP and AMP in the meconium of previously confirmed specimens, additional research will determine if inclusion of these analytes can increase identification of MAMP-exposed neonates. Novel methamphetamine biomarker concentrations were characterized in meconium of infants exposed in utero to MAMP. JF - Therapeutic drug monitoring AU - Gray, Teresa R AU - Kelly, Tamsin AU - LaGasse, Linda L AU - Smith, Lynne M AU - Derauf, Chris AU - Haning, William AU - Grant, Penny AU - Shah, Rizwan AU - Arria, Amelia AU - Strauss, Arthur AU - Lester, Barry M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 70 EP - 75 VL - 31 IS - 1 KW - Biomarkers KW - 0 KW - Central Nervous System Stimulants KW - Sympathomimetics KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Young Adult KW - Mass Spectrometry KW - Humans KW - Gestational Age KW - Infant, Newborn KW - Sympathomimetics -- analysis KW - Chromatography, High Pressure Liquid KW - Pregnancy KW - Biotransformation KW - Adult KW - Female KW - Pregnancy Outcome KW - Methamphetamine -- pharmacokinetics KW - Meconium -- chemistry KW - Central Nervous System Stimulants -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66839228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+drug+monitoring&rft.atitle=Novel+biomarkers+of+prenatal+methamphetamine+exposure+in+human+meconium.&rft.au=Gray%2C+Teresa+R%3BKelly%2C+Tamsin%3BLaGasse%2C+Linda+L%3BSmith%2C+Lynne+M%3BDerauf%2C+Chris%3BHaning%2C+William%3BGrant%2C+Penny%3BShah%2C+Rizwan%3BArria%2C+Amelia%3BStrauss%2C+Arthur%3BLester%2C+Barry+M%3BHuestis%2C+Marilyn+A&rft.aulast=Gray&rft.aufirst=Teresa&rft.date=2009-02-01&rft.volume=31&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Therapeutic+drug+monitoring&rft.issn=1536-3694&rft_id=info:doi/10.1097%2FFTD.0b013e318195d7cb LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-12 N1 - Date created - 2009-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chromatogr. 1986 Apr 25;377:279-86 [3711218] Arch Toxicol. 1986 Oct;59(3):135-40 [3813878] Am J Obstet Gynecol. 1990 Nov;163(5 Pt 1):1535-42 [2240103] Drug Metab Dispos. 1993 Jul-Aug;21(4):717-23 [8104133] Biol Pharm Bull. 1993 Sep;16(9):817-21 [7903574] J Anal Toxicol. 1993 Oct;17(6):348-52 [8271781] Clin Chem. 1995 Nov;41(11):1614-6 [7586551] Biochem Pharmacol. 1996 Feb 23;51(4):403-11 [8619884] J Anal Toxicol. 1996 Oct;20(6):453-62 [8889682] Drug Metab Dispos. 1997 Sep;25(9):1059-64 [9311621] J Anal Toxicol. 1998 Jul-Aug;22(4):329-35 [9681337] J Chromatogr B Biomed Sci Appl. 1998 Aug 21;713(1):163-87 [9700558] J Anal Toxicol. 1999 Oct;23(6):436-45 [10517548] J Anal Toxicol. 1999 Oct;23(6):446-51 [10517549] Early Hum Dev. 2005 Jul;81(7):573-81 [16009282] Forensic Sci Int. 2005 Oct 4;153(1):29-37 [15922530] Forensic Sci Int. 2005 Oct 4;153(1):59-65 [15923097] Clin Pharmacokinet. 2005;44(10):989-1008 [16176115] Xenobiotica. 2006 Feb-Mar;36(2-3):259-67 [16702115] Matern Child Health J. 2006 May;10(3):293-302 [16395620] Pediatrics. 2006 Sep;118(3):1149-56 [16951010] Am J Drug Alcohol Abuse. 2007;33(2):281-9 [17497551] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 15;867(2):194-204 [18424195] Drug Metab Dispos. 2008 Aug;36(8):1587-93 [18474679] Biochem J. 1972 Aug;129(1):11-22 [4646771] J Anal Toxicol. 2003 Oct;27(7):471-8 [14607002] J Anal Toxicol. 2003 Jul-Aug;27(5):265-9 [12908938] Forensic Sci Int. 2003 Apr 23;133(1-2):101-6 [12742695] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jun 5;789(1):27-41 [12726841] Arch Dis Child Fetal Neonatal Ed. 2003 Mar;88(2):F98-F100 [12598495] J Dev Behav Pediatr. 2003 Feb;24(1):17-23 [12584481] Clin Chem. 2002 Oct;48(10):1703-14 [12324487] J Anal Toxicol. 2002 Jul-Aug;26(5):267-73 [12166813] J Pediatr. 2001 Mar;138(3):344-8 [11241040] Pediatrics. 2001 Feb;107(2):309-17 [11158464] Biochem J. 1972 Aug;129(1):25-9 [4646778] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/FTD.0b013e318195d7cb ER - TY - JOUR T1 - Limbal stem cell deficiency arising from systemic chemotherapy with hydroxycarbamide. AN - 66837379; 19158571 AB - The purpose of this study was to report a case of limbal stem cell deficiency (LSCD) after systemic chemotherapy with hydroxycarbamide. Clinical manifestations and pathology are detailed. We describe the case of a woman with sickle cell disease, who developed bilateral LSCD after treatment with hydroxycarbamide. Histologic examination confirmed the diagnosis of LSCD, revealing goblet cells, inflammatory cells, deposits of new collagen components, and neovascularization in the peripheral cornea. Matrix metalloproteinase-3, fibronectin, and collagen III were also detected in the lesions. The systemic use of the antineoplastic drug, hydroxycarbamide, may cause severe LSCD. We recommend that a medication history, including that of cytotoxic drugs, be considered in evaluating LSCD. JF - Cornea AU - Ding, Xiaoyan AU - Bishop, Rachel J AU - Herzlich, Alexandra A AU - Patel, Mrinali AU - Chan, Chi-Chao AD - Section of Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1857, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 221 EP - 223 VL - 28 IS - 2 KW - Antisickling Agents KW - 0 KW - Hydroxyurea KW - X6Q56QN5QC KW - Index Medicus KW - Conjunctival Diseases -- pathology KW - Pterygium -- pathology KW - Conjunctival Diseases -- chemically induced KW - Humans KW - Neovascularization, Pathologic -- metabolism KW - Neovascularization, Pathologic -- chemically induced KW - Middle Aged KW - Cornea -- metabolism KW - Anemia, Sickle Cell -- drug therapy KW - Immunohistochemistry KW - Neovascularization, Pathologic -- pathology KW - Female KW - Stem Cells -- drug effects KW - Limbus Corneae -- blood supply KW - Antisickling Agents -- adverse effects KW - Antisickling Agents -- therapeutic use KW - Limbus Corneae -- metabolism KW - Stem Cells -- pathology KW - Hydroxyurea -- therapeutic use KW - Hydroxyurea -- adverse effects KW - Limbus Corneae -- drug effects KW - Limbus Corneae -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66837379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cornea&rft.atitle=Limbal+stem+cell+deficiency+arising+from+systemic+chemotherapy+with+hydroxycarbamide.&rft.au=Ding%2C+Xiaoyan%3BBishop%2C+Rachel+J%3BHerzlich%2C+Alexandra+A%3BPatel%2C+Mrinali%3BChan%2C+Chi-Chao&rft.aulast=Ding&rft.aufirst=Xiaoyan&rft.date=2009-02-01&rft.volume=28&rft.issue=2&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Cornea&rft.issn=1536-4798&rft_id=info:doi/10.1097%2FICO.0b013e318183a3bd LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-01-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Surv Ophthalmol. 2000 Mar-Apr;44(5):415-25 [10734241] Cornea. 2000 May;19(3):284-7 [10832684] Br J Ophthalmol. 2001 Mar;85(3):373-4 [11277104] Ann Acad Med Singapore. 2004 Sep;33(5):576-80 [15531952] N Engl J Med. 1995 May 18;332(20):1372-4 [7536300] J Cell Biol. 1999 May 17;145(4):769-82 [10330405] Am J Ophthalmol. 2004 May;137(5):950-1 [15126170] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/ICO.0b013e318183a3bd ER - TY - JOUR T1 - Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. AN - 66835129; 19074761 AB - The exposure of cells to several metal ions stabilizes HIF-1 alpha protein. However, the molecular mechanisms are not completely understood. They may involve inhibition of hydroxylation by either substitution of iron by metal ions or by iron oxidation in the hydroxylases. Here we provide evidence supporting the latter mechanism. We show that HIF-1 alpha stabilization in human lung epithelial cells occurred following exposure to various metal and metalloid ions, including those that cannot substitute for iron in the hydroxylases. In each case addition of the reducing agent ascorbic acid (AA)* abolished HIF-1 alpha protein stabilization. To better understand the role of iron oxidation in hydroxylase inhibition and to define the role of AA in the enzyme recovery we applied molecular modeling techniques. Our results indicate that the energy required for iron substitution by Ni(II) in the enzyme is high and unlikely to be achieved in a biological system. Additionally, computer modeling allowed us to identify a tridentate coordination of AA with the enzyme-bound iron, which explains the specific demand for AA as the iron reductant. Thus, the stabilization of HIF-1 alpha by numerous metal ions that cannot substitute for iron in the enzyme, the alleviation of this effect by AA, and our computer modeling data support the hypothesis of iron oxidation in the hydroxylases following exposure to metal ions. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Kaczmarek, Monika AU - Cachau, Raul E AU - Topol, Igor A AU - Kasprzak, Kazimierz S AU - Ghio, Andy AU - Salnikow, Konstantin AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 394 EP - 403 VL - 107 IS - 2 KW - Antioxidants KW - 0 KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Indicators and Reagents KW - Metals KW - Iron KW - E1UOL152H7 KW - Mixed Function Oxygenases KW - EC 1.- KW - Luciferases KW - EC 1.13.12.- KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Models, Molecular KW - Humans KW - Genes, Reporter -- drug effects KW - Ascorbic Acid -- pharmacology KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Stimulation, Chemical KW - Oxidation-Reduction KW - Blotting, Western KW - Antioxidants -- pharmacology KW - Kinetics KW - Molecular Conformation KW - Luciferases -- genetics KW - Cell Line KW - Mixed Function Oxygenases -- metabolism KW - Hypoxia-Inducible Factor 1, alpha Subunit -- chemistry KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Iron -- metabolism KW - Metals -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66835129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Metal+ions-stimulated+iron+oxidation+in+hydroxylases+facilitates+stabilization+of+HIF-1+alpha+protein.&rft.au=Kaczmarek%2C+Monika%3BCachau%2C+Raul+E%3BTopol%2C+Igor+A%3BKasprzak%2C+Kazimierz+S%3BGhio%2C+Andy%3BSalnikow%2C+Konstantin&rft.aulast=Kaczmarek&rft.aufirst=Monika&rft.date=2009-02-01&rft.volume=107&rft.issue=2&rft.spage=394&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfn251 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-11 N1 - Date created - 2009-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2000 Feb 15;14(4):391-6 [10691731] Free Radic Biol Med. 2007 Apr 15;42(8):1246-57 [17382205] Science. 2001 Apr 20;292(5516):464-8 [11292862] Science. 2001 Apr 20;292(5516):468-72 [11292861] Cell Growth Differ. 2001 Jul;12(7):363-9 [11457733] Biosci Biotechnol Biochem. 2001 Aug;65(8):1707-12 [11577707] Environ Health Perspect. 2002 Feb;110 Suppl 1:89-94 [11834466] Curr Opin Chem Biol. 2002 Apr;6(2):193-201 [12039004] J Biol Chem. 2002 Aug 30;277(35):31963-71 [12070140] J Biol Chem. 2003 Feb 28;278(9):6885-95 [12482858] Cancer Res. 2003 Apr 15;63(8):1764-8 [12702559] Mutat Res. 2003 Dec 10;533(1-2):183-200 [14643420] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83 [15070760] Cancer Biol Ther. 2004 Jan;3(1):29-35 [14726713] Nat Rev Mol Cell Biol. 2004 May;5(5):343-54 [15122348] J Biol Chem. 2004 Sep 24;279(39):40337-44 [15271983] Biochim Biophys Acta. 1981 Jan 15;657(1):159-67 [6260196] Biochim Biophys Acta. 1982 Jun 4;704(2):326-32 [6285984] Science. 1988 Dec 9;242(4884):1412-5 [2849206] Free Radic Res Commun. 1990;10(1-2):37-45 [2165984] Free Radic Res Commun. 1992;17(6):369-76 [1337535] Protein Eng. 1994 Jul;7(7):831-9 [7971945] J Biol Chem. 1995 Jan 20;270(3):1230-7 [7836384] Am J Physiol. 1995 Mar;268(3 Pt 1):L347-60 [7900815] J Toxicol Environ Health. 1997 Feb 21;50(3):285-305 [9055877] Anticancer Res. 1997 Mar-Apr;17(2A):1125-9 [9137459] Eur J Biochem. 1997 Dec 15;250(3):625-9 [9461283] Carcinogenesis. 1999 Sep;20(9):1819-23 [10469629] Carcinogenesis. 2004 Dec;25(12):2497-507 [15297373] Am J Respir Cell Mol Biol. 2005 May;32(5):395-403 [15695738] Blood. 2005 Jun 15;105(12):4613-9 [15741220] Toxicol Sci. 2005 Aug;86(2):248-57 [15888669] Toxicol Lett. 2005 Aug 14;158(2):152-7 [16039403] Mol Cell Biochem. 2005 Nov;279(1-2):157-62 [16283525] J Phys Chem A. 2006 Mar 30;110(12):4223-8 [16553373] J Cell Biochem. 2006 Apr 1;97(5):1025-35 [16288478] Toxicol Appl Pharmacol. 2006 Jun 15;213(3):245-55 [16386771] Mol Carcinog. 2006 Jul;45(7):479-89 [16649251] Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9814-9 [16782814] Mutat Res. 2006 Nov 7;610(1-2):48-55 [16877034] J Immunol. 2006 Nov 15;177(10):7211-24 [17082639] FEBS J. 2007 Jan;274(1):1-22 [17222174] Biochem J. 2007 Mar 1;402(2):261-9 [17078813] Biosci Biotechnol Biochem. 2000 Mar;64(3):476-83 [10803943] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfn251 ER - TY - JOUR T1 - Utility of methylation markers in cervical cancer early detection: appraisal of the state-of-the-science. AN - 66830292; 19054549 AB - We wanted to identify the most promising methylation marker candidates for cervical cancer early detection. A systematic literature review was performed in Medline and weighted average frequencies for methylated genes stratified by tissue source and methods used were computed. 51 studies were identified analyzing 68 different genes for methylation in 4376 specimens across all stages of cervical carcinogenesis. 15 genes, DAPK1, RASSF1, CDH1, CDKN2A, MGMT, RARB, APC, FHIT, MLH1, TIMP3, GSTP1, CADM1, CDH13, HIC1, and TERT have been analyzed in 5 or more studies. The published data on these genes is highly heterogeneous; 7 genes (CDH1, FHIT, TERT, CDH13, MGMT, TIMP3, and HIC1) had a reported range of methylation frequencies in cervical cancers of greater than 60% between studies. Stratification by analysis method did not resolve the heterogeneity. Three markers, DAPK1, CADM1, and RARB, showed elevated methylation in cervical cancers consistently across studies. There is currently no methylation marker that can be readily translated for use in cervical cancer screening or triage settings. Large, well-conducted methylation profiling studies of cervical carcinogenesis could yield new candidates that are more specific for HPV-related carcinogenesis. New candidate markers need to be thoroughly validated in highly standardized assays. JF - Gynecologic oncology AU - Wentzensen, Nicolas AU - Sherman, Mark E AU - Schiffman, Mark AU - Wang, Sophia S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5012, Rockville, MD 20854-7234, USA. wentzenn@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 293 EP - 299 VL - 112 IS - 2 KW - Genetic Markers KW - 0 KW - Index Medicus KW - Carcinoma, Squamous Cell -- diagnosis KW - Humans KW - Papillomavirus Infections -- complications KW - Papillomavirus Infections -- virology KW - Adenocarcinoma -- genetics KW - Papillomavirus Infections -- genetics KW - Carcinoma, Squamous Cell -- virology KW - Adenocarcinoma -- diagnosis KW - Carcinoma, Squamous Cell -- genetics KW - Early Detection of Cancer KW - Adenocarcinoma -- virology KW - Female KW - DNA Methylation KW - Cervical Intraepithelial Neoplasia -- genetics KW - Uterine Cervical Neoplasms -- diagnosis KW - Uterine Cervical Neoplasms -- genetics KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66830292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gynecologic+oncology&rft.atitle=Utility+of+methylation+markers+in+cervical+cancer+early+detection%3A+appraisal+of+the+state-of-the-science.&rft.au=Wentzensen%2C+Nicolas%3BSherman%2C+Mark+E%3BSchiffman%2C+Mark%3BWang%2C+Sophia+S&rft.aulast=Wentzensen&rft.aufirst=Nicolas&rft.date=2009-02-01&rft.volume=112&rft.issue=2&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Gynecologic+oncology&rft.issn=1095-6859&rft_id=info:doi/10.1016%2Fj.ygyno.2008.10.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-26 N1 - Date created - 2009-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1178-84 [17548682] Gynecol Oncol. 2007 Jun;105(3):662-6 [17360030] Exp Biol Med (Maywood). 2007 Jul;232(7):881-6 [17609503] Hum Genet. 2007 Aug;122(1):71-81 [17609981] Dis Markers. 2007;23(4):315-30 [17627065] Cancer Lett. 2007 Sep 18;255(1):26-33 [17467893] Lancet. 2007 Sep 8;370(9590):890-907 [17826171] N Engl J Med. 2007 Oct 18;357(16):1579-88 [17942871] N Engl J Med. 2007 Oct 18;357(16):1589-97 [17942872] Br J Cancer. 2007 Nov 19;97(10):1457-64 [17971771] Lancet. 2007 Nov 24;370(9601):1764-72 [17919718] Gynecol Oncol. 2007 Dec;107(3):549-53 [17894941] Cancer. 2008 Feb 25;114(1):57-64 [18181097] N Engl J Med. 2008 Mar 13;358(11):1148-59 [18337604] IARC Monogr Eval Carcinog Risks Hum. 2007;90:1-636 [18354839] Cancer Res. 2008 Apr 1;68(7):2489-97 [18381458] Int J Cancer. 2008 Jul 1;123(1):161-7 [18398837] Vaccine. 2008 Mar 14;26 Suppl 1:A16-23 [18642468] Arch Gynecol Obstet. 2008 Jun;277(6):505-9 [18026971] Eur J Cancer. 2008 Nov;44(16):2496-505 [18722107] J Obstet Gynaecol Res. 2007 Jun;33(3):236-41 [17578348] Clin Cancer Res. 2001 Mar;7(3):584-9 [11297252] Clin Cancer Res. 2001 Jul;7(7):1982-6 [11448914] JAMA. 2002 Apr 24;287(16):2114-9 [11966386] BMC Cancer. 2002 Mar 21;2:4 [11945179] Int J Cancer. 2003 Jun 10;105(2):204-9 [12673680] Cancer Res. 2003 Apr 15;63(8):1888-93 [12702579] Eur J Cancer. 2003 Mar;39(4):517-23 [12751384] Int J Oncol. 2003 Sep;23(3):599-604 [12888893] Clin Cancer Res. 2003 Aug 1;9(8):2981-4 [12912945] Ultrastruct Pathol. 2003 Nov-Dec;27(6):417-22 [14660280] Int J Cancer. 2004 Mar 1;108(6):882-6 [14712492] Clin Cancer Res. 2004 Jan 15;10(2):565-71 [14760078] J Natl Cancer Inst. 2004 Feb 18;96(4):294-305 [14970278] Int J Cancer. 2004 May 1;109(5):786-92 [14999791] Lab Invest. 2004 Apr;84(4):479-84 [14968123] Am J Obstet Gynecol. 2004 Mar;190(3):674-9 [15041998] Gynecol Oncol. 2004 May;93(2):407-16 [15099954] Gynecol Oncol. 2004 May;93(2):435-40 [15099958] Cancer Res. 2004 May 1;64(9):2994-7 [15126331] Clin Cancer Res. 2004 May 15;10(10):3396-400 [15161694] Mol Cancer Res. 2004 May;2(5):289-95 [15192122] Gynecol Oncol. 2004 Jun;93(3):621-7 [15196854] Mol Cancer. 2003 May 13;2:24 [12773202] Cancer. 2004 Aug 25;102(4):259-68 [15368319] Cancer Lett. 1999 Mar 1;136(2):231-5 [10355753] Int J Cancer. 2005 Feb 10;113(4):600-4 [15472908] Gynecol Oncol. 2005 Jan;96(1):150-8 [15589594] Gynecol Oncol. 2005 Jan;96(1):173-80 [15589597] J Natl Cancer Inst. 2005 Feb 16;97(4):273-82 [15713962] Int J Cancer. 2005 Jul 1;115(4):503-10 [15700311] Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):114-23 [16434596] Int J Cancer. 2006 May 1;118(9):2168-71 [16331610] BMC Cancer. 2006;6:55 [16524460] Mol Cancer. 2006;5:16 [16700909] Int J Gynecol Cancer. 2006 May-Jun;16(3):1234-40 [16803511] Int J Cancer. 2006 Oct 15;119(8):1908-14 [16736496] Oncogene. 2006 Aug 31;25(39):5436-45 [16607278] Int J Gynecol Cancer. 2006 Sep-Oct;16(5):1862-7 [17009983] Oncogene. 2007 Feb 8;26(6):934-44 [16862168] Gynecol Oncol. 2007 Mar;104(3):629-35 [17097722] Comment In: Gynecol Oncol. 2009 Feb;112(2):291-2 [19150524] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ygyno.2008.10.012 ER - TY - JOUR T1 - Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. AN - 66829381; 18841445 AB - To evaluate the in vivo efficacy of curcumin as an inhibitor of the multidrug-resistance-linked ATP Binding Cassette (ABC) drug transporter, ABCG2. Photoaffinity labeling with [125I]-iodoarylazidoprazosin was used to characterize the interaction of sulfasalazine, a substrate of the mouse ABCG2, with human ABCG2. In addition, the inhibitory effect of curcumin on ABCG2 was evaluated in brain capillaries from rats. Furthermore, the effect of curcumin on absorption of orally administered sulfasalazine in wild-type and abcg2-/- mice was also determined. Sulfasalazine interacted at the drug-substrate site(s) of human ABCG2. Curcumin inhibited ABCG2 activity at nanomolar concentrations at the rat blood-brain barrier in the ex vivo assay. Based on studies in wild type and abcg2-/- mice, we observed that oral curcumin increased Cmax and relative bioavailability of sulfasalazine by selectively inhibiting ABCG2 function. This study validates our previous in vitro results with human ABCG2 (Chearwae et al., Mol. Cancer Ther. 5:1995-2006, 2006) and provides the first in vivo evidence for the inhibition by curcumin of ABCG2-mediated efflux of sulfasalazine in mice. Based on these studies, we propose that non-toxic concentrations of curcumin may be used to enhance drug exposure when the rate-limiting step of drug absorption and/or tissue distribution is impacted by ABCG2. JF - Pharmaceutical research AU - Shukla, Suneet AU - Zaher, Hani AU - Hartz, Anika AU - Bauer, Björn AU - Ware, Joseph A AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, 20892-4256, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 480 EP - 487 VL - 26 IS - 2 SN - 0724-8741, 0724-8741 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Abcg2 protein, mouse KW - Abcg2 protein, rat KW - Antineoplastic Agents, Phytogenic KW - Azides KW - BODIPY-FL prazosin KW - Boron Compounds KW - Neoplasm Proteins KW - P-Glycoproteins KW - multidrug resistance protein 3 KW - Sulfasalazine KW - 3XC8GUZ6CB KW - azidoprazosin KW - 90990-97-9 KW - Curcumin KW - IT942ZTH98 KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Administration, Oral KW - Prazosin -- metabolism KW - Animals KW - Drug Interactions KW - Neoplasm Proteins -- antagonists & inhibitors KW - Prazosin -- analogs & derivatives KW - Dose-Response Relationship, Drug KW - Humans KW - Sulfasalazine -- blood KW - Cell Line, Tumor KW - Mice KW - Mice, Knockout KW - Biological Availability KW - Rats KW - Boron Compounds -- metabolism KW - Azides -- metabolism KW - Rats, Sprague-Dawley KW - P-Glycoproteins -- genetics KW - Sulfasalazine -- pharmacokinetics KW - Sulfasalazine -- administration & dosage KW - P-Glycoproteins -- deficiency KW - Drug Resistance, Neoplasm -- drug effects KW - Blood-Brain Barrier -- drug effects KW - ATP-Binding Cassette Transporters -- metabolism KW - Blood-Brain Barrier -- metabolism KW - Antineoplastic Agents, Phytogenic -- pharmacology KW - ATP-Binding Cassette Transporters -- genetics KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors KW - Curcumin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66829381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+research&rft.atitle=Curcumin+inhibits+the+activity+of+ABCG2%2FBCRP1%2C+a+multidrug+resistance-linked+ABC+drug+transporter+in+mice.&rft.au=Shukla%2C+Suneet%3BZaher%2C+Hani%3BHartz%2C+Anika%3BBauer%2C+Bj%C3%B6rn%3BWare%2C+Joseph+A%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2009-02-01&rft.volume=26&rft.issue=2&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+research&rft.issn=07248741&rft_id=info:doi/10.1007%2Fs11095-008-9735-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-23 N1 - Date created - 2009-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2003 Oct 20;22(47):7468-85 [14576852] Anticancer Res. 2003 Jan-Feb;23(1A):363-98 [12680238] Eur J Pharm Sci. 2004 Jan;21(1):25-51 [14706810] Mol Pharmacol. 2004 Mar;65(3):675-84 [14978246] Mol Pharmacol. 2004 Sep;66(3):413-9 [15322232] Biochem Pharmacol. 2004 Nov 15;68(10):2043-52 [15476675] Toxicol Appl Pharmacol. 1997 Sep;146(1):88-94 [9299600] Methods Enzymol. 1998;292:504-14 [9711578] Cancer Lett. 2005 Jun 8;223(2):181-90 [15896452] Eur J Cancer. 2005 Sep;41(13):1955-68 [16081279] Clin Cancer Res. 2005 Oct 15;11(20):7490-8 [16243823] Cancer Chemother Pharmacol. 2006 Feb;57(3):376-88 [16021489] Mol Pharmacol. 2006 Jan;69(1):195-206 [16219905] Mol Pharmacol. 2006 Feb;69(2):462-70 [16278373] Nat Rev Drug Discov. 2006 Mar;5(3):219-34 [16518375] Biochem Pharmacol. 2006 May 14;71(10):1397-421 [16563357] Mol Pharm. 2006 Jan-Feb;3(1):55-61 [16686369] Biochemistry. 2006 Jul 25;45(29):8940-51 [16846237] Mol Cancer Ther. 2006 Aug;5(8):1995-2006 [16928820] Mol Pharmacol. 2006 Oct;70(4):1212-9 [16837625] Mol Pharmacol. 2006 Nov;70(5):1664-71 [16880289] Mol Pharmacol. 2007 Mar;71(3):667-75 [17132686] Mol Cell Biochem. 2007 Feb;296(1-2):85-95 [16960658] Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7 [17051370] Curr Probl Cancer. 2007 Jul-Aug;31(4):243-305 [17645940] Mol Pharm. 2007 Nov-Dec;4(6):807-18 [17999464] J Bioenerg Biomembr. 2007 Dec;39(5-6):465-71 [17990087] Expert Opin Drug Metab Toxicol. 2008 Feb;4(2):205-23 [18248313] Pharmacogenet Genomics. 2008 May;18(5):439-48 [18408567] Mol Pharmacol. 2008 May;73(5):1444-53 [18094072] Clin Pharmacol Ther. 2008 Jul;84(1):95-103 [18167504] Pharmacol Rev. 2008 Jun;60(2):196-209 [18560012] Clin Cancer Res. 2008 Jul 15;14(14):4491-9 [18628464] FASEB J. 2008 Aug;22(8):2723-33 [18474546] J Natl Cancer Inst. 2000 Oct 18;92(20):1651-6 [11036110] Clin Cancer Res. 2001 Jan;7(1):145-52 [11205902] Biochim Biophys Acta. 2001 Jun 6;1512(2):171-82 [11406094] Biochem Biophys Res Commun. 2002 May 17;293(4):1273-8 [12054514] J Clin Oncol. 2002 Jul 1;20(13):2943-50 [12089223] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15649-54 [12429862] Mol Cancer Ther. 2002 Apr;1(6):417-25 [12477054] Oncologist. 2002;7(6):516-30 [12490739] FASEB J. 2003 Nov;17(14):2085-7 [12958161] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11095-008-9735-8 ER - TY - JOUR T1 - 9-Cis-retinoic acid reduces ischemic brain injury in rodents via bone morphogenetic protein. AN - 66828964; 18803283 AB - Retinoic acid (RA), a biologically active derivative of vitamin A, has protective effects against damage caused by H(2)O(2) or oxygen-glucose deprivation in mesangial and PC12 cells. In cultured human osteosarcoma cells, RA enhances the expression of bone morphogenetic protein-7 (BMP7), a trophic factor that reduces ischemia- or neurotoxin-mediated neurodegeneration in vivo. The purpose of this study is to examine whether RA reduces ischemic brain injury through a BMP7 mechanism. We found that intracerebroventricular administration of 9-cis-retinoic acid (9cRA) enhanced BMP7 mRNA expression, detected by RT-PCR, in rat cerebral cortex at 24 hr after injection. Rats were also subjected to transient focal ischemia induced by ligation of the middle cerebral artery (MCA) at 1 day after 9cRA injection. Pretreatment with 9cRA increased locomotor activity and attenuated neurological deficits 2 days after MCA ligation. 9cRA also reduced cerebral infarction and TUNEL labeling. These protective responses were antagonized by the BMP antagonist noggin given 1 day after 9cRA injection. Taken together, our data suggest that 9cRA has protective effects against ischemia-induced injury, and these effects involve BMPs. 2008 Wiley-Liss, Inc. JF - Journal of neuroscience research AU - Shen, Hui AU - Luo, Yu AU - Kuo, Chi-Chung AU - Deng, Xiaolin AU - Chang, Chen-Fu AU - Harvey, Brandon K AU - Hoffer, Barry J AU - Wang, Yun AD - National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland 21224, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 545 EP - 555 VL - 87 IS - 2 KW - Bone Morphogenetic Protein 7 KW - 0 KW - Carrier Proteins KW - Neuroprotective Agents KW - RNA, Messenger KW - noggin protein KW - 148294-77-3 KW - alitretinoin KW - 1UA8E65KDZ KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Animals KW - Carrier Proteins -- pharmacology KW - Gene Expression KW - RNA, Messenger -- analysis KW - Recovery of Function -- drug effects KW - Reverse Transcriptase Polymerase Chain Reaction KW - Injections, Intraventricular KW - Rats KW - In Situ Nick-End Labeling KW - Rats, Sprague-Dawley KW - Infarction, Middle Cerebral Artery -- pathology KW - Motor Activity -- drug effects KW - Infarction, Middle Cerebral Artery -- drug therapy KW - Infarction, Middle Cerebral Artery -- etiology KW - Male KW - Bone Morphogenetic Protein 7 -- biosynthesis KW - Brain Ischemia -- drug therapy KW - Brain Ischemia -- pathology KW - Brain Ischemia -- complications KW - Neuroprotective Agents -- administration & dosage KW - Bone Morphogenetic Protein 7 -- drug effects KW - Tretinoin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66828964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+psychiatry&rft.atitle=One+SNP+linked+to+two+diseases-addiction+and+cancer%3A+a+double+whammy%3F+Nicotine+addiction+and+lung+cancer+susceptibility.&rft.au=Volkow%2C+N%3BRutter%2C+J%3BPollock%2C+J+D%3BShurtleff%2C+D%3BBaler%2C+R&rft.aulast=Volkow&rft.aufirst=N&rft.date=2008-11-01&rft.volume=13&rft.issue=11&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=Molecular+psychiatry&rft.issn=1476-5578&rft_id=info:doi/10.1038%2Fmp.2008.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2009-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Dev Dyn. 2001 Nov;222(3):341-53 [11747070] Arch Biochem Biophys. 2001 Sep 15;393(2):262-70 [11556813] J Cell Physiol. 2002 Feb;190(2):207-17 [11807825] Neuropharmacology. 2002 Sep;43(3):418-26 [12243771] Nephrol Dial Transplant. 2002;17 Suppl 9:84-7 [12386300] J Neurochem. 2002 Dec;83(5):1072-86 [12437578] Dev Dyn. 2003 Feb;226(2):237-44 [12557202] Stroke. 2003 Feb;34(2):558-64 [12574575] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7135-40 [12782789] Eur J Neurosci. 2003 Aug;18(3):457-72 [12911743] J Neurosci. 2003 Aug 27;23(21):7958-65 [12944527] Eur J Neurosci. 2003 Sep;18(5):1033-40 [12956703] Arch Biochem Biophys. 2003 Dec 1;420(1):185-93 [14622989] Brain Res. 2004 Jun 4;1010(1-2):55-61 [15126117] Brain Res. 2004 Oct 1;1022(1-2):88-95 [15353217] Neurosci Lett. 2004 Oct 14;369(2):138-41 [15450683] Stroke. 1986 Jul-Aug;17(4):738-43 [2943059] Nature. 1990 May 17;345(6272):224-9 [2159111] Nature. 1992 Jan 23;355(6358):359-61 [1309942] Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3067-71 [8159708] J Biol Chem. 1994 Jun 17;269(24):16689-95 [8206989] J Neurosci Res. 1995 Jan 1;40(1):1-9 [7714916] Dev Dyn. 1995 Mar;202(3):312-23 [7780180] Neurosci Lett. 1995 Feb 24;187(1):21-4 [7617293] Thromb Res. 1995 Jun 1;78(5):379-87 [7660354] J Neurochem. 1998 Jan;70(1):47-58 [9422346] J Neurochem. 1998 Jun;70(6):2484-91 [9603213] Neuroreport. 1998 Nov 16;9(16):3615-21 [9858369] Stroke. 1999 Jan;30(1):126-33 [9880400] Dev Biol. 1999 Apr 1;208(1):30-43 [10075839] Neuroscience. 2006;137(1):241-51 [16289892] Neuroscience. 2007 Jun 15;147(1):153-63 [17521827] J Neurosci Res. 2007 Oct;85(13):2950-9 [17628501] Neuroscience. 2008 Jan 2;151(1):92-103 [18082966] Acta Neurochir Suppl. 2008;101:93-8 [18642641] J Neurosci. 1999 Nov 15;19(22):10107-15 [10559418] J Neurosci Res. 2000 Jun 15;60(6):767-78 [10861789] Science. 2000 Dec 15;290(5499):2140-4 [11118147] Free Radic Biol Med. 2001 May 15;30(10):1067-77 [11369496] Stroke. 2001 Sep;32(9):2170-8 [11546913] Neuroscience. 2002;109(2):231-41 [11801360] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jnr.21865 ER - TY - JOUR T1 - rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit. AN - 66827567; 19029250 AB - The translational GTPases promote initiation, elongation, and termination of protein synthesis by interacting with the ribosome. Mutations that impair GTP hydrolysis by eukaryotic translation initiation factor 5B/initiation factor 2 (eIF5B/IF2) impair yeast cell growth due to failure to dissociate from the ribosome following subunit joining. A mutation in helix h5 of the 18S rRNA in the 40S ribosomal subunit and intragenic mutations in domain II of eIF5B suppress the toxic effects associated with expression of the eIF5B-H480I GTPase-deficient mutant in yeast by lowering the ribosome binding affinity of eIF5B. Hydroxyl radical mapping experiments reveal that the domain II suppressors interface with the body of the 40S subunit in the vicinity of helix h5. As the helix h5 mutation also impairs elongation factor function, the rRNA and eIF5B suppressor mutations provide in vivo evidence supporting a functionally important docking of domain II of the translational GTPases on the body of the small ribosomal subunit. JF - Molecular and cellular biology AU - Shin, Byung-Sik AU - Kim, Joo-Ran AU - Acker, Michael G AU - Maher, Kathryn N AU - Lorsch, Jon R AU - Dever, Thomas E AD - Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2427, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 808 EP - 821 VL - 29 IS - 3 KW - Eukaryotic Initiation Factor-2 KW - 0 KW - FUN12 protein, S cerevisiae KW - Peptide Elongation Factor 1 KW - RNA, Ribosomal, 18S KW - Saccharomyces cerevisiae Proteins KW - Hydroxyl Radical KW - 3352-57-6 KW - Histidine KW - 4QD397987E KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - Index Medicus KW - Base Sequence KW - Conserved Sequence KW - Amino Acid Motifs KW - Peptide Elongation Factor 1 -- metabolism KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Genes, Suppressor KW - Amino Acid Substitution KW - Binding Sites KW - Protein Biosynthesis KW - GTP Phosphohydrolases -- chemistry KW - Saccharomyces cerevisiae Proteins -- genetics KW - Suppression, Genetic -- genetics KW - Saccharomyces cerevisiae -- growth & development KW - Ribosome Subunits, Small -- genetics KW - Eukaryotic Initiation Factor-2 -- genetics KW - RNA, Ribosomal, 18S -- chemistry KW - Saccharomyces cerevisiae -- enzymology KW - Saccharomyces cerevisiae -- genetics KW - GTP Phosphohydrolases -- metabolism KW - Ribosome Subunits, Small -- enzymology KW - RNA, Ribosomal, 18S -- genetics KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Eukaryotic Initiation Factor-2 -- chemistry KW - Saccharomyces cerevisiae -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66827567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=rRNA+suppressor+of+a+eukaryotic+translation+initiation+factor+5B%2Finitiation+factor+2+mutant+reveals+a+binding+site+for+translational+GTPases+on+the+small+ribosomal+subunit.&rft.au=Shin%2C+Byung-Sik%3BKim%2C+Joo-Ran%3BAcker%2C+Michael+G%3BMaher%2C+Kathryn+N%3BLorsch%2C+Jon+R%3BDever%2C+Thomas+E&rft.aulast=Shin&rft.aufirst=Byung-Sik&rft.date=2009-02-01&rft.volume=29&rft.issue=3&rft.spage=808&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.00896-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2009-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Jan 20;403(6767):332-5 [10659855] Methods Enzymol. 2007;429:185-201 [17913624] Mol Cell Biol. 2000 Oct;20(19):7183-91 [10982835] Nucleic Acids Res. 2000 Sep 15;28(18):3524-34 [10982872] Genes Dev. 2000 Oct 1;14(19):2534-46 [11018020] Cell. 2000 Nov 22;103(5):781-92 [11114334] RNA. 2001 Aug;7(8):1173-9 [11497435] Cell. 2001 Nov 2;107(3):361-72 [11701126] Cell. 2001 Nov 2;107(3):373-86 [11701127] Trends Biochem Sci. 2001 Dec;26(12):705-9 [11738593] Annu Rev Biochem. 2001;70:415-35 [11395413] Cell. 2002 Feb 22;108(4):557-72 [11909526] Biochemistry. 2002 Oct 22;41(42):12806-12 [12379123] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16689-94 [12471154] Cell. 2002 Dec 27;111(7):1015-25 [12507428] EMBO J. 2003 Jan 15;22(2):175-82 [12514123] Nat Struct Biol. 2003 May;10(5):379-85 [12692531] Cold Spring Harb Symp Quant Biol. 2001;66:425-37 [12762045] RNA. 2003 Aug;9(8):958-69 [12869707] RNA. 2003 Aug;9(8):1019-24 [12869712] EMBO J. 2003 Oct 15;22(20):5593-601 [14532131] Nat Struct Biol. 2003 Nov;10(11):899-906 [14566331] Nature. 2004 Feb 26;427(6977):862-5 [14985767] EMBO J. 2004 Mar 10;23(5):1008-19 [14976550] Mol Cell. 2004 Apr 23;14(2):233-45 [15099522] J Cell Physiol. 1980 Sep;104(3):269-81 [7419605] Arch Microbiol. 1983 Aug;135(1):63-7 [6354131] EMBO J. 1984 Jan;3(1):113-20 [6323160] Biochemistry. 1987 Apr 7;26(7):2047-54 [3297141] Methods Enzymol. 1988;164:481-9 [2468070] Nature. 1991 Jan 10;349(6305):117-27 [1898771] Nature. 1993 Sep 9;365(6442):126-32 [8371755] Structure. 1993 Sep 15;1(1):35-50 [8069622] Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1113-6 [7862644] Structure. 1996 Mar 15;4(3):229-38 [8805530] EMBO J. 1996 Dec 2;15(23):6766-74 [8978702] Annu Rev Biochem. 1997;66:639-78 [9242920] RNA. 1997 Aug;3(8):870-81 [9257646] Nature. 1997 Sep 25;389(6649):403-6 [9311785] Proc Natl Acad Sci U S A. 1998 May 26;95(11):6134-8 [9600930] Science. 1999 Sep 24;285(5436):2095-104 [10497122] Cell. 2005 Jun 3;121(5):703-12 [15935757] Cell. 2005 Jul 1;121(7):991-1004 [15989950] Nat Struct Mol Biol. 2005 Dec;12(12):1145-9 [16284619] Eukaryot Cell. 2006 Apr;5(4):762-70 [16607023] J Biol Chem. 2006 Sep 29;281(39):29011-21 [16849329] J Biol Chem. 2006 Oct 27;281(43):32639-48 [16950777] Mol Cell Biol. 2007 Mar;27(5):1677-85 [17189426] Mol Cell Biol. 2007 Mar;27(6):2384-97 [17242201] Mol Cell. 2007 Mar 9;25(5):751-64 [17349960] EMBO J. 2007 May 2;26(9):2421-31 [17446867] Cell. 2007 Jun 1;129(5):929-41 [17540173] EMBO J. 2007 Jul 11;26(13):3109-23 [17568775] Nature. 2008 Sep 18;455(7211):416-20 [18758445] Science. 2000 Aug 11;289(5481):905-20 [10937989] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.00896-08 ER - TY - JOUR T1 - Vitamin E intake, alpha-tocopherol status, and pancreatic cancer in a cohort of male smokers. AN - 66824525; 19116326 AB - Evidence indicates that vitamin E has anticarcinogenic properties for gastrointestinal cancers; however, few studies have examined this with respect to exocrine pancreatic cancer. The objective was to examine whether vitamin E intake and serum alpha-tocopherol concentrations were prospectively associated with exocrine pancreatic cancer. We conducted a cohort analysis of prediagnostic vitamin E intake (4 tocopherols, 4 tocotrienols), serum alpha-tocopherol concentrations, and pancreatic cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of male Finnish smokers aged 50-69 y at baseline. During follow-up from 1985 to 2004 (maximum: 19.4 y; median: 16 y), 318 incident cases were diagnosed among cohort participants with complete serum samples (n = 29,092); 306 cases had complete dietary data (n = 27,111). Cox proportional hazards models adjusted for age, smoking history, history of diabetes mellitus, and/or serum cholesterol were used to calculate hazard ratios (HRs) and 95% CIs. Higher alpha-tocopherol concentrations were associated with lower pancreatic cancer risk (highest compared with lowest quintile, HR: 0.52; 95% CI: 0.34, 0.80; P for trend = 0.03; continuous HR: 0.91; 95% CI: 0.84, 0.99). Polyunsaturated fat, a putative prooxidant nutrient, modified the association such that the inverse alpha-tocopherol association was most pronounced in subjects with a high polyunsaturated fat intake (ie, >9.9 g/d; highest compared with lowest quintile, HR: 0.38; 95% CI: 0.20, 0.70; P for trend = 0.03; continuous HR: 0.86; 95% CI: 0.75, 0.97; P for interaction = 0.05 and 0.02, respectively). No associations were observed for dietary tocopherols and tocotrienols. Our results support the hypothesis that higher alpha-tocopherol concentrations may play a protective role in pancreatic carcinogenesis in male smokers. JF - The American journal of clinical nutrition AU - Stolzenberg-Solomon, Rachael Z AU - Sheffler-Collins, Seth AU - Weinstein, Stephanie AU - Garabrant, David H AU - Mannisto, Satu AU - Taylor, Philip AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health Human Services, Rockville, MD, USA. rs221z@nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 584 EP - 591 VL - 89 IS - 2 KW - Antioxidants KW - 0 KW - Dietary Fats KW - Dietary Fats, Unsaturated KW - Vitamin E KW - 1406-18-4 KW - alpha-Tocopherol KW - H4N855PNZ1 KW - Abridged Index Medicus KW - Index Medicus KW - Odds Ratio KW - Humans KW - Aged KW - Dietary Fats -- administration & dosage KW - Antioxidants -- metabolism KW - Prospective Studies KW - Risk Factors KW - Cohort Studies KW - Confidence Intervals KW - Middle Aged KW - Finland -- epidemiology KW - Male KW - Antioxidants -- administration & dosage KW - Proportional Hazards Models KW - Dietary Fats, Unsaturated -- administration & dosage KW - Smoking -- blood KW - alpha-Tocopherol -- blood KW - Pancreatic Neoplasms -- prevention & control KW - Pancreatic Neoplasms -- blood KW - Smoking -- adverse effects KW - Pancreatic Neoplasms -- epidemiology KW - Vitamin E -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66824525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Vitamin+E+intake%2C+alpha-tocopherol+status%2C+and+pancreatic+cancer+in+a+cohort+of+male+smokers.&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BSheffler-Collins%2C+Seth%3BWeinstein%2C+Stephanie%3BGarabrant%2C+David+H%3BMannisto%2C+Satu%3BTaylor%2C+Philip%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2009-02-01&rft.volume=89&rft.issue=2&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=1938-3207&rft_id=info:doi/10.3945%2Fajcn.2008.26423 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-11 N1 - Date created - 2009-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1981 Dec;67(6):1327-32 [6273636] Cancer Res. 1981 Mar;41(3):888-93 [7459874] Am J Epidemiol. 1986 Jul;124(1):17-27 [3521261] J Natl Cancer Inst. 1987 Feb;78(2):289-93 [3468292] Am J Epidemiol. 1988 Jan;127(1):28-41 [3276161] Cancer Lett. 1988 Aug 15;41(2):179-89 [3401841] Am J Epidemiol. 1988 Sep;128(3):655-66 [2458036] Prev Med. 1989 Jan;18(1):11-9 [2785267] Am J Clin Nutr. 1989 May;49(5):895-900 [2718925] Am J Clin Nutr. 1991 Jan;53(1 Suppl):260S-264S [1985396] Am J Clin Nutr. 1991 Jan;53(1 Suppl):283S-286S [1985399] Am J Public Health. 1991 Apr;81(4):466-70 [2003626] IARC Sci Publ. 1991;(105):54-61 [1855913] Int J Vitam Nutr Res. 1991;61(1):27-32 [1856041] Ann N Y Acad Sci. 1992 Sep 30;669:269-79 [1444032] Ann Epidemiol. 1994 Jan;4(1):1-10 [8205268] Am J Clin Nutr. 1996 Apr;63(4):559-65 [8599320] Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):885-93 [8634662] J Clin Epidemiol. 1996 May;49(5):511-7 [8636724] IARC Sci Publ. 1996;(139):189-201 [8923031] Cancer. 1999 Jul 1;86(1):37-42 [10391561] Am J Clin Nutr. 2005 Jan;81(1):95-103 [15640466] Pancreatology. 2005;5(4-5):403-9 [15985764] Nutr Cancer. 2005;52(2):225-33 [16201853] Free Radic Biol Med. 2007 Jul 1;43(1):4-15 [17561088] Cochrane Database Syst Rev. 2008;(3):CD004183 [18677777] Aliment Pharmacol Ther. 2008 Sep 15;28(6):689-703 [19145725] Food Chem Toxicol. 1999 Sep-Oct;37(9-10):981-4 [10541454] J Surg Res. 2000 Jan;88(1):23-5 [10644462] Prostaglandins Leukot Essent Fatty Acids. 2001 Sep;65(3):165-71 [11728167] J Clin Lab Anal. 2001;15(6):324-30 [11793433] Am J Epidemiol. 2002 May 1;155(9):783-92 [11978580] Cancer Causes Control. 2002 Jun;13(5):417-26 [12146846] Acta Oncol. 2002;41(4):381-8 [12234031] JAMA. 2003 Jul 23;290(4):476-85 [12876090] Arterioscler Thromb Vasc Biol. 2004 May;24(5):816-23 [14976002] Cochrane Database Syst Rev. 2004;(4):CD004183 [15495084] Scand J Gastroenterol. 2004 Sep;39(9):882-5 [15513387] J Natl Cancer Inst. 1983 Aug;71(2):355-60 [6308322] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3945/ajcn.2008.26423 ER - TY - JOUR T1 - Comparative pharmacodynamic interaction analysis between ciprofloxacin, moxifloxacin and levofloxacin and antifungal agents against Candida albicans and Aspergillus fumigatus. AN - 66814606; 19109335 AB - Patients suffering from invasive mycoses often receive concomitant antifungal therapy and antibacterial agents. Ciprofloxacin, a carboxyfluoroquinolone, was previously observed to demonstrate the pharmacodynamic interactions with antifungal agents by altering their growth inhibitory activity against Candida albicans and Aspergillus fumigatus. However, little is known about the interaction between other extended-spectrum fluoroquinolones, such as levofloxacin and moxifloxacin, and antifungal agents against C. albicans and A. fumigatus. Using a microdilution chequerboard technique, we employed isobolographic analysis adapted to incorporate a non-active agent in order to analyse the potential in vitro interaction between ciprofloxacin, levofloxacin or moxifloxacin and the following representative antifungal agents: amphotericin B, fluconazole or voriconazole and caspofungin. Synergistic interactions [interaction indices (Iis) 0.69-0.83, P < 0.05] were observed between amphotericin B (0.07-0.31 mg/L) and either ciprofloxacin (0.19-7.65 mg/L) or levofloxacin (0.41-32.88 mg/L) against C. albicans and A. fumigatus. Synergy (Iis 0.56-0.87, P < 0.05) also was found between voriconazole (0.09-0.14 mg/L) and ciprofloxacin (0.22-11.41 mg/L) as well as between caspofungin (8.94-22.07 mg/L) and levofloxacin (0.14-5.17 mg/L) against A. fumigatus. Some antagonistic (Iis 1.16-1.29, P < 0.05) interactions were observed between fluoroquinolones and fluconazole against C. albicans. In general, ciprofloxacin enhanced the activity of antifungal agents more than moxifloxacin and levofloxacin against both C. albicans and A. fumigatus. The knowledge of the pharmacodynamic interactions between fluoroquinolones and antifungal agents may guide selection and potentially improve the outcome of immunosuppressed patients with concurrent bacterial and fungal infections. JF - The Journal of antimicrobial chemotherapy AU - Stergiopoulou, Theodouli AU - Meletiadis, Joseph AU - Sein, Tin AU - Papaioannidou, Paraskevi AU - Tsiouris, Ioannis AU - Roilides, Emmanuel AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, Clinical Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 343 EP - 348 VL - 63 IS - 2 KW - Anti-Bacterial Agents KW - 0 KW - Antifungal Agents KW - Aza Compounds KW - Fluoroquinolones KW - Quinolines KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Levofloxacin KW - 6GNT3Y5LMF KW - Ofloxacin KW - A4P49JAZ9H KW - moxifloxacin KW - U188XYD42P KW - Index Medicus KW - Humans KW - Drug Synergism KW - Drug Antagonism KW - Microbial Sensitivity Tests KW - Ciprofloxacin -- pharmacology KW - Quinolines -- pharmacology KW - Antifungal Agents -- pharmacology KW - Ofloxacin -- pharmacology KW - Aza Compounds -- pharmacology KW - Anti-Bacterial Agents -- pharmacology KW - Aspergillus fumigatus -- drug effects KW - Candida albicans -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66814606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Comparative+pharmacodynamic+interaction+analysis+between+ciprofloxacin%2C+moxifloxacin+and+levofloxacin+and+antifungal+agents+against+Candida+albicans+and+Aspergillus+fumigatus.&rft.au=Stergiopoulou%2C+Theodouli%3BMeletiadis%2C+Joseph%3BSein%2C+Tin%3BPapaioannidou%2C+Paraskevi%3BTsiouris%2C+Ioannis%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Stergiopoulou&rft.aufirst=Theodouli&rft.date=2009-02-01&rft.volume=63&rft.issue=2&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=1460-2091&rft_id=info:doi/10.1093%2Fjac%2Fdkn473 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-16 N1 - Date created - 2009-01-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Antimicrob Chemother. 2006 Feb;57(2):230-5 [16352735] Int J Antimicrob Agents. 2008 Jan;31(1):21-6 [18054465] Antimicrob Agents Chemother. 2008 Jun;52(6):2196-204 [18299413] Surv Ophthalmol. 2005 Nov;50 Suppl 1:S32-45 [16257309] Microb Drug Resist. 2005 Fall;11(3):232-8 [16201925] Antimicrob Agents Chemother. 2005 Jun;49(6):2429-37 [15917543] Clin Microbiol Infect. 2005 Apr;11(4):256-80 [15760423] Antimicrob Agents Chemother. 1997 Nov;41(11):2518-21 [9371359] Antimicrob Agents Chemother. 1996 Dec;40(12):2859-64 [9124855] Antimicrob Agents Chemother. 1995 Jul;39(7):1517-21 [7492096] Antimicrob Agents Chemother. 1992 Dec;36(12):2778-84 [1336349] Drugs Exp Clin Res. 1988;14(1):9-18 [3292181] Antimicrob Agents Chemother. 2004 Jul;48(7):2673-82 [15215125] J Mol Model. 2004 Jun;10(3):223-32 [15118877] Infect Dis Clin North Am. 2003 Dec;17(4):785-800 [15008599] Antimicrob Agents Chemother. 2002 Aug;46(8):2442-9 [12121916] J Infect Chemother. 2000 Sep;6(3):151-4 [11810556] Curr Opin Oncol. 2006 Jul;18(4):325-9 [16721125] Int J Antimicrob Agents. 2006 Dec;28(6):551-9 [17101261] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/jac/dkn473 ER - TY - JOUR T1 - Endothelial effects of emission source particles: acute toxic response gene expression profiles. AN - 66813807; 19000753 AB - Air pollution epidemiology has established a strong association between exposure to ambient particulate matter (PM) and cardiovascular outcomes. Experimental studies in both humans and laboratory animals support varied biological mechanisms including endothelial dysfunction as potentially a central step to the elicitation of cardiovascular events. We therefore hypothesized that relevant early molecular alterations on endothelial cells should be assessable in vitro upon acute exposure to PM components previously shown to be involved in health outcomes. Using a model emission PM, residual oil fly ash and one of its predominant constituents (vanadium-V), we focused on the development of gene expression profiles to fingerprint that particle and its constituents to explore potential biomarkers for PM-induced endothelial dysfunction. Here we present differential gene expression and transcription factor activation profiles in human vascular endothelial cells exposed to a non-cytotoxic dose of fly ash or V following semi-global gene expression profiling of approximately 8000 genes. Both fly ash and it's prime constituent, V, induced alterations in genes involved in passive and active transport of solutes across the membrane; voltage-dependent ion pumps; induction of extracellular matrix proteins and adhesion molecules; and activation of numerous kinases involved in signal transduction pathways. These preliminary data suggest that cardiovascular effects associated with exposure to PM may be mediated by perturbations in endothelial cell permeability, membrane integrity; and ultimately endothelial dysfunction. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Nadadur, Srikanth S AU - Haykal-Coates, Najwa AU - Mudipalli, Anuradha AU - Costa, Daniel L AD - Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health Environmental Effects Research Laboratory, ORD, US EPA, Research Triangle Park, NC 27711, USA. Nadadurs@niehs.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 67 EP - 77 VL - 23 IS - 1 SN - 0887-2333, 0887-2333 KW - Air Pollutants KW - 0 KW - Coal Ash KW - Particulate Matter KW - Vanadium KW - 00J9J9XKDE KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Vanadium -- toxicity KW - Toxicity Tests, Acute KW - Cell Line KW - Umbilical Veins -- metabolism KW - Particulate Matter -- toxicity KW - Gene Expression -- drug effects KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- drug effects KW - Umbilical Veins -- pathology KW - Endothelium, Vascular -- pathology KW - Umbilical Veins -- drug effects KW - Air Pollutants -- toxicity KW - Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66813807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Endothelial+effects+of+emission+source+particles%3A+acute+toxic+response+gene+expression+profiles.&rft.au=Nadadur%2C+Srikanth+S%3BHaykal-Coates%2C+Najwa%3BMudipalli%2C+Anuradha%3BCosta%2C+Daniel+L&rft.aulast=Nadadur&rft.aufirst=Srikanth&rft.date=2009-02-01&rft.volume=23&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2008.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Occup Environ Med. 1999 Nov;41(11):973-80 [10570503] Environ Health Perspect. 2007 Dec;115(12):1701-3 [18087586] Circ Res. 2001 Feb 2;88(2):210-6 [11157674] Toxicol Sci. 2001 Jun;61(2):356-67 [11353144] Hum Exp Toxicol. 2001 May;20(5):259-65 [11476159] J Appl Physiol (1985). 2001 Oct;91(4):1487-500 [11568129] Toxicol Sci. 2001 Dec;64(2):243-52 [11719707] Exp Lung Res. 2002 Jan-Feb;28(1):19-38 [11792073] Circulation. 2002 Apr 2;105(13):1534-6 [11927516] Environ Health Perspect. 2002 Aug;110(8):A440-1 [12153769] J Toxicol Environ Health A. 2002 Sep 27;65(18):1333-50 [12227955] J Toxicol Environ Health A. 2002 Oct 25;65(20):1513-30 [12396866] J Toxicol Environ Health A. 2002 Oct 25;65(20):1531-43 [12396867] Environ Health Perspect. 2002 Dec;110(12):1191-7 [12460797] Toxicology. 2003 May 3;187(2-3):161-70 [12699905] Vascul Pharmacol. 2002 Nov;39(4-5):173-85 [12747958] Hypertens Res. 2003 Sep;26(9):685-9 [14620922] Circulation. 2004 Jan 6;109(1):71-7 [14676145] Pflugers Arch. 2004 Feb;447(5):465-8 [14624363] Circulation. 2004 Jun 1;109(21):2655-71 [15173049] Inhal Toxicol. 2004 Jun;16(6-7):437-45 [15204759] Q Rev Biophys. 2003 Nov;36(4):373-427 [15267168] Environ Health Perspect. 2004 Sep;112(13):1299-306 [15345343] J Occup Med. 1984 Aug;26(8):567-70 [6332888] Am J Physiol. 1994 Sep;267(3 Pt 1):L223-41 [7943249] Am J Physiol. 1995 Jul;269(1 Pt 1):C103-9 [7631735] Jpn J Pharmacol. 1995 Jun;68(2):183-9 [7563975] Can J Physiol Pharmacol. 1996 Jul;74(7):787-800 [8946065] J Toxicol Environ Health. 1997 Feb 21;50(3):285-305 [9055877] Environ Res. 1997 Feb;72(2):162-72 [9177658] Environ Health Perspect. 1997 Sep;105 Suppl 5:1053-60 [9400700] Toxicol Sci. 1998 Feb;41(2):209-16 [9520357] Can J Physiol Pharmacol. 2004 Oct;82(10):833-9 [15573143] Environ Health Perspect. 2005 Feb;113(2):201-6 [15687058] Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L460-7 [15908475] Proc Am Thorac Soc. 2005;2(1):61-7 [16113470] Circ Res. 2005 Oct 28;97(9):853-63 [16254217] Environ Health Perspect. 2005 Nov;113(11):1575-9 [16263514] J Cell Biochem. 2005 Dec 15;96(6):1110-26 [16167340] Curr Hypertens Rep. 2005 Dec;7(6):427-34 [16386198] Toxicol Sci. 2006 Apr;90(2):385-91 [16407093] J Air Waste Manag Assoc. 2006 Jun;56(6):709-42 [16805397] Clin Occup Environ Med. 2006;5(4):797-815 [17110293] Front Biosci. 2007;12:1238-46 [17127377] Inhal Toxicol. 2007 Feb;19(2):133-40 [17169860] Pharmacol Ther. 2007 Jan;113(1):16-29 [16920197] Arch Biochem Biophys. 2007 Jun 15;462(2):176-88 [17321483] Toxicol Sci. 2007 Jul;98(1):231-9 [17434951] Inhal Toxicol. 2007;19 Suppl 1:67-73 [17886053] J Toxicol Environ Health A. 2007 Nov;70(21):1824-37 [17934955] Am J Ind Med. 2000 Apr;37(4):353-63 [10706747] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tiv.2008.10.004 ER - TY - JOUR T1 - Pharmacologically induced hypogonadism and sexual function in healthy young women and men. AN - 66811691; 18354393 AB - Studies fail to find uniform effects of age-related or induced hypogonadism on human sexual function. We examined the effects of induced hypogonadism on sexual function in healthy men and women and attempted to identify predictors of the sexual response to induced hypogonadism or hormone addback. The study design used was a double-blind, controlled, crossover (self-as-own control). The study setting was an ambulatory care clinic in a research hospital, and the participants were 20 men (average+/-SD age=28.5+/-6.2 years) and 20 women (average+/-SD age=33.5+/-8.7 years), all healthy and with no history of psychiatric illness. A multidimensional scale assessing several domains of sexual function was the main outcome measure. Participants of the study received depot leuprolide acetate (Lupron) every 4 weeks for 3 months (men) or 5 months (women). After the first month of Lupron alone, men received (in addition to Lupron) testosterone enanthate (200 mg intramuscularly) or placebo every 2 weeks for 1 month each. Women received Lupron alone for 2 months, and then, in addition to Lupron, they received estradiol and progesterone for 5 weeks each. The results of the study: in women, hypogonadism resulted in a significant decrease in global measures of sexual functioning, principally reflecting a significant decrease in the reported quality of orgasm. In men, hypogonadism resulted in significant reductions in all measured domains of sexual function. Testosterone restored sexual functioning scores in men to those seen at baseline, whereas neither estradiol nor progesterone significantly improved the reduced sexual functioning associated with hypogonadism in women. Induced hypogonadism decreased sexual function in a similar number of men and women. No predictors of response were identified except for levels of sexual function at baseline. In conclusion, our data do not support a simple deficiency model for the role of gonadal steroids in human sexual function; moreover, while variable, the role of testosterone in sexual function in men is more apparent than that of estradiol or progesterone in women. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Schmidt, Peter J AU - Steinberg, Emma M AU - Negro, Paula Palladino AU - Haq, Nazli AU - Gibson, Carolyn AU - Rubinow, David R AD - Behavioral Endocrinology Branch, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892-1276, USA. peterschmidt@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 565 EP - 576 VL - 34 IS - 3 KW - Dihydrotestosterone KW - 08J2K08A3Y KW - Testosterone KW - 3XMK78S47O KW - Progesterone KW - 4G7DS2Q64Y KW - Estradiol KW - 4TI98Z838E KW - Leuprolide KW - EFY6W0M8TG KW - Index Medicus KW - Orgasm -- drug effects KW - Sex Characteristics KW - Humans KW - Adult KW - Middle Aged KW - Dihydrotestosterone -- blood KW - Affect KW - Sexual Dysfunction, Physiological -- drug therapy KW - Male KW - Female KW - Testosterone -- therapeutic use KW - Progesterone -- therapeutic use KW - Estradiol -- physiology KW - Testosterone -- physiology KW - Hypogonadism -- physiopathology KW - Hypogonadism -- chemically induced KW - Leuprolide -- pharmacology KW - Progesterone -- physiology KW - Estradiol -- blood KW - Sexual Behavior -- physiology KW - Testosterone -- blood KW - Estradiol -- therapeutic use KW - Hypogonadism -- drug therapy KW - Progesterone -- blood KW - Sexual Behavior -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66811691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+%26+Adolescent+Psychiatric+Nursing&rft.atitle=Sex+Partner+Type+and+Condom+Use+in+African+American+Adolescent+Mothers%3A+A+Literature+Review&rft.au=Nelson%2C+LaRon+E%3BMorrison-Beedy%2C+Dianne&rft.aulast=Nelson&rft.aufirst=LaRon&rft.date=2008-11-01&rft.volume=21&rft.issue=4&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+%26+Adolescent+Psychiatric+Nursing&rft.issn=10736077&rft_id=info:doi/10.1111%2Fj.1744-6171.2008.00140.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-30 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychosom Med. 1991 Jul-Aug;53(4):363-74 [1924649] Arch Sex Behav. 1992 Apr;21(2):101-19 [1580784] Maturitas. 1993 Jan;16(1):49-60 [8429803] Am J Obstet Gynecol. 1993 Mar;168(3 Pt 1):824-30 [8456888] Acta Obstet Gynecol Scand. 1993 Nov;72(8):656-60 [8259754] J Clin Endocrinol Metab. 1994 Mar;78(3):711-6 [8126146] J Psychosom Obstet Gynaecol. 1993 Dec;14(4):283-93 [8142982] J Sex Marital Ther. 1994 Spring;20(1):3-13 [8169964] Psychoneuroendocrinology. 1994;19(3):293-304 [8202577] J Intern Med. 1995 May;237(5):479-86 [7738488] J Clin Endocrinol Metab. 1995 Dec;80(12):3537-45 [8530596] J Clin Endocrinol Metab. 1995 Dec;80(12):3546-52 [8530597] J Clin Endocrinol Metab. 1996 Apr;81(4):1495-501 [8636357] Psychol Med. 1996 Sep;26(5):925-36 [8878326] Psychoneuroendocrinology. 1996 Aug;21(6):545-58 [8983090] Hum Reprod. 1997 Feb;12(2):209-13 [9070697] J Sex Marital Ther. 1997 Winter;23(4):291-304 [9427208] Horm Behav. 1998 Apr;33(2):95-103 [9647935] Int J Impot Res. 1998 May;10 Suppl 2:S91-3; discussion S98-101 [9647968] J Clin Endocrinol Metab. 1998 Jul;83(7):2281-5 [9661595] Am J Psychiatry. 1998 Oct;155(10):1310-8 [9766760] J Reprod Med. 1998 Oct;43(10):847-56 [9800666] N Engl J Med. 1999 Sep 30;341(14):1013-20 [10502590] J Clin Endocrinol Metab. 1999 Oct;84(10):3556-62 [10522995] Endocrinology. 1952 Sep;51(3):237-48 [12989118] J Comp Physiol Psychol. 1953 Apr;46(2):138-44 [13044875] J Clin Endocrinol Metab. 1999 Nov;84(11):4025-30 [10566644] J Clin Endocrinol Metab. 2000 Jan;85(1):60-5 [10634364] Psychoneuroendocrinology. 2000 Jan;25(1):53-68 [10633535] J Clin Endocrinol Metab. 2000 Aug;85(8):2670-7 [10946864] J Clin Endocrinol Metab. 2000 Aug;85(8):2832-8 [10946891] J Clin Endocrinol Metab. 2000 Aug;85(8):2839-53 [10946892] Arch Gen Psychiatry. 1961 Jun;4:561-71 [13688369] Menopause. 2004 Nov-Dec;11(6 Pt 2):749-65 [15543027] Aging Male. 2004 Sep;7(3):188-96 [15669537] Psychoneuroendocrinology. 2005 Jun;30(5):413-7 [15721053] J Sex Marital Ther. 2005 Jan-Feb;31(1):73-80 [15841707] Eur Urol. 2005 Jun;47(6):749-55 [15925068] J Clin Endocrinol Metab. 2005 Jul;90(7):3838-46 [15827094] Arch Intern Med. 2005 Jul 25;165(14):1582-9 [16043675] J Clin Endocrinol Metab. 2005 Aug;90(8):4836-45 [15840738] Urology. 2005 Sep;66(3):597-601 [16140085] J Clin Endocrinol Metab. 2005 Sep;90(9):5226-33 [16014407] Clin Endocrinol (Oxf). 2005 Oct;63(4):381-94 [16181230] J Clin Oncol. 2005 Oct 1;23(28):6890-8 [16129845] Neurology. 2005 Oct 11;65(7):1016-20 [16217052] Maturitas. 2006 Jan 10;53(1):11-8 [16183220] Am J Psychiatry. 2006 Jan;163(1):59-66 [16390890] Neuropsychopharmacology. 2006 Mar;31(3):659-74 [16160708] Arch Gen Psychiatry. 2006 Apr;63(4):450-6 [16585475] J Clin Endocrinol Metab. 2006 Apr;91(4):1323-8 [16434455] Menopause. 2006 Jan-Feb;13(1):37-45 [16607097] Menopause. 2006 Jan-Feb;13(1):46-56 [16607098] J Clin Endocrinol Metab. 2006 Jul;91(7):2509-13 [16670164] J Clin Endocrinol Metab. 2007 Feb;92(2):405-13 [17090633] Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2465-70 [17267613] Pharmacol Biochem Behav. 2007 Feb;86(2):209-19 [16979750] Mayo Clin Proc. 2000 Jan;75 Suppl:S70-5; discussion S75-6 [10959221] N Engl J Med. 2000 Sep 7;343(10):682-8 [10974131] J Clin Endocrinol Metab. 2001 Jun;86(6):2380-90 [11397827] Horm Behav. 2001 Sep;40(2):339-57 [11534996] J Clin Endocrinol Metab. 2002 May;87(5):2046-52 [11994339] Fertil Steril. 2002 Apr;77 Suppl 4:S42-8 [12007901] Clin Endocrinol (Oxf). 2002 Jun;56(6):779-86 [12072048] Climacteric. 2002 Dec;5(4):357-65 [12626215] J Clin Endocrinol Metab. 2003 Jun;88(6):2673-81 [12788872] Fertil Steril. 2003 Jun;79(6):1341-52 [12798881] Fam Cancer. 2001;1(3-4):149-56 [14574171] Arch Gen Psychiatry. 2004 Oct;61(10):997-1004 [15466673] Maturitas. 2004 Oct 15;49(2):124-33 [15474756] J Androl. 2004 Nov-Dec;25(6):963-72 [15477371] Mayo Clin Proc. 1969 Jul;44(7):461-5 [5788255] J Clin Endocrinol Metab. 1970 Oct;31(4):362-8 [5453328] Steroids. 1970 Oct;16(4):415-28 [5533947] Steroids. 1971 Jul;18(1):91-111 [5107186] J Clin Endocrinol Metab. 1971 Nov;33(5):759-67 [5125384] Obstet Gynecol. 1977 Jan;49(1):92-6 [831167] J Sex Marital Ther. 1976 Fall;2(3):214-28 [1034710] Br J Obstet Gynaecol. 1977 Oct;84(10):769-75 [921914] N Engl J Med. 1978 Nov 23;299(21):1145-50 [703805] J Clin Endocrinol Metab. 1979 Jun;48(6):955-8 [447801] Clin Endocrinol (Oxf). 1980 Apr;12(4):327-40 [6991164] Obstet Gynecol. 1980 Sep;56(3):316-22 [7422170] Am J Obstet Gynecol. 1981 Aug 1;140(7):725-9 [7196155] J Clin Endocrinol Metab. 1983 Jul;57(1):71-7 [6602143] J Clin Endocrinol Metab. 1983 Sep;57(3):557-62 [6874890] Psychosom Med. 1985 Jul-Aug;47(4):339-51 [4023162] Maturitas. 1985 Sep;7(3):211-6 [3935901] Maturitas. 1985 Sep;7(3):225-33 [4079822] Clin Endocrinol (Oxf). 1985 Nov;23(5):527-38 [3910302] Psychosom Med. 1987 Jul-Aug;49(4):397-409 [3615768] Obstet Gynecol. 1990 Apr;75(4 Suppl):26S-30S; discussion 31S-35S [2179787] J Clin Endocrinol Metab. 1990 Apr;70(4):1124-31 [1690746] Neurosci Biobehav Rev. 1990 Summer;14(2):233-41 [2190122] J Clin Endocrinol Metab. 1991 Feb;72(2):336-43 [1846872] Erratum In: Neuropsychopharmacology. 2009 Feb;34(3):816 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.24 ER - TY - JOUR T1 - Pentoxifylline inhibits replication of Japanese encephalitis virus: a comparative study with ribavirin. AN - 66804929; 18804347 AB - Several investigations have shown that pentoxifylline possesses broad-spectrum antiviral activity against a range of RNA and DNA viruses. However, its ability to inhibit Japanese encephalitis virus (JEV) replication has not yet been studied. The present study was designed to investigate the antiviral activity of pentoxifylline against JEV in vitro and in vivo. The activity of pentoxifylline against JEV was evaluated in vitro using cytopathic effect inhibition and plaque reduction assays. Pentoxifylline was able to inhibit JEV replication in a dose-dependent manner at a 50% inhibitory concentration (IC(50)) of 50.3microg/mL (0.00018microM) and a therapeutic index (TI) of 10. Experiments to study the mechanism of antiviral action of pentoxifylline using in vitro translation of viral mRNA suggested that the drug did not interfere either with early or late protein synthesis but most likely exerted its action on virus assembly and/or release. Furthermore, the in vivo study showed that pentoxifylline at a concentration of 100mg/kg and 200mg/kg body weight was able to protect completely mice challenged with 50 x 50% lethal dose (LD(50)) of JEV. JF - International journal of antimicrobial agents AU - Sebastian, Liba AU - Desai, Anita AU - Madhusudana, Shampur Narayan AU - Ravi, Vasanthapuram AD - Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 168 EP - 173 VL - 33 IS - 2 SN - 0924-8579, 0924-8579 KW - Antiviral Agents KW - 0 KW - Ribavirin KW - 49717AWG6K KW - Pentoxifylline KW - SD6QCT3TSU KW - Index Medicus KW - Animals KW - Viral Plaque Assay KW - Mice KW - Encephalitis, Japanese -- drug therapy KW - Inhibitory Concentration 50 KW - Microbial Sensitivity Tests KW - Cytopathogenic Effect, Viral -- drug effects KW - Survival Analysis KW - Antiviral Agents -- therapeutic use KW - Ribavirin -- therapeutic use KW - Pentoxifylline -- pharmacology KW - Pentoxifylline -- therapeutic use KW - Virus Replication -- drug effects KW - Ribavirin -- pharmacology KW - Antiviral Agents -- pharmacology KW - Encephalitis Virus, Japanese -- physiology KW - Encephalitis Virus, Japanese -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66804929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+antimicrobial+agents&rft.atitle=Pentoxifylline+inhibits+replication+of+Japanese+encephalitis+virus%3A+a+comparative+study+with+ribavirin.&rft.au=Sebastian%2C+Liba%3BDesai%2C+Anita%3BMadhusudana%2C+Shampur+Narayan%3BRavi%2C+Vasanthapuram&rft.aulast=Sebastian&rft.aufirst=Liba&rft.date=2009-02-01&rft.volume=33&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=International+journal+of+antimicrobial+agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2008.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-10 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijantimicag.2008.07.013 ER - TY - JOUR T1 - Radiation-sensitive genetically susceptible pediatric sub-populations. AN - 66802605; 19083227 AB - Major advances in pediatric cancer treatment have resulted in substantial improvements in survival. However, concern has emerged about the late effects of cancer therapy, especially radiation-related second cancers. Studies of childhood cancer patients with inherited cancer syndromes can provide insights into the interaction between radiation and genetic susceptibility to multiple cancers. Children with retinoblastoma (Rb), neurofibromatosis type 1 (NF1), Li-Fraumeni syndrome (LFS), and nevoid basal cell carcinoma syndrome (NBCCS) are at substantial risk of developing radiation-related second and third cancers. A radiation dose-response for bone and soft-tissue sarcomas has been observed in hereditary Rb patients, with many of these cancers occurring in the radiation field. Studies of NF1 patients irradiated for optic pathway gliomas have reported increased risks of developing another cancer associated with radiotherapy. High relative risks for second and third cancers were observed for a cohort of 200 LFS family members, especially children, possibly related to radiotherapy. Children with NBCCS are very sensitive to radiation and develop multiple basal cell cancers in irradiated areas. Clinicians following these patients should be aware of their increased genetic susceptibility to multiple primary malignancies enhanced by sensitivity to ionizing radiation. JF - Pediatric radiology AU - Kleinerman, Ruth A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA. kleinerr@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - S27 EP - S31 VL - 39 Suppl 1 SN - 0301-0449, 0301-0449 KW - Index Medicus KW - Basal Cell Nevus Syndrome -- radiotherapy KW - Radiation Dosage KW - Neurofibromatosis 1 -- radiotherapy KW - Retinal Neoplasms -- genetics KW - Humans KW - Retinoblastoma -- genetics KW - Retinal Neoplasms -- radiotherapy KW - Retinoblastoma -- radiotherapy KW - Li-Fraumeni Syndrome KW - Child KW - Basal Cell Nevus Syndrome -- genetics KW - Neurofibromatosis 1 -- genetics KW - Neoplastic Syndromes, Hereditary -- genetics KW - Neoplastic Syndromes, Hereditary -- radiotherapy KW - Neoplasms, Second Primary -- genetics KW - Neoplasms, Radiation-Induced -- genetics KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66802605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+radiology&rft.atitle=Radiation-sensitive+genetically+susceptible+pediatric+sub-populations.&rft.au=Kleinerman%2C+Ruth+A&rft.aulast=Kleinerman&rft.aufirst=Ruth&rft.date=2009-02-01&rft.volume=39+Suppl+1&rft.issue=&rft.spage=S27&rft.isbn=&rft.btitle=&rft.title=Pediatric+radiology&rft.issn=03010449&rft_id=info:doi/10.1007%2Fs00247-008-1015-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2009-01-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 1969 Oct;71(4):747-52 [5360287] Health Phys. 2003 Jul;85(1):47-59 [12852471] Cancer. 1986 May 15;57(10):2006-21 [3082508] Br J Cancer. 1986 May;53(5):661-71 [3718823] Medicine (Baltimore). 1987 Mar;66(2):98-113 [3547011] Cancer Res. 1988 Sep 15;48(18):5358-62 [3409256] N Engl J Med. 1988 Oct 20;319(16):1033-9 [3173432] Science. 1990 Nov 30;250(4985):1233-8 [1978757] Br J Cancer. 1991 Nov;64(5):959-61 [1931625] N Engl J Med. 1992 May 14;326(20):1309-15 [1565144] Radiat Res. 1995 Mar;141(3):259-77 [7871153] Radiat Res. 1996 May;145(5):595-601 [8619025] Int J Cancer. 1996 Aug 7;67(4):515-9 [8759610] JAMA. 1997 Oct 15;278(15):1262-7 [9333268] Cancer Causes Control. 1997 Nov;8(6):865-71 [9427429] J Natl Cancer Inst. 1998 Apr 15;90(8):606-11 [9554443] Int J Radiat Oncol Biol Phys. 2005 Feb 1;61(2):583-93 [15667981] J Clin Oncol. 2005 Apr 1;23(10):2272-9 [15800318] Cancer Cell. 2005 Oct;8(4):271-3 [16226702] J Med Genet. 2006 Apr;43(4):289-94 [16155191] J Clin Oncol. 2006 Jun 1;24(16):2570-5 [16735710] Pediatr Radiol. 2006 Sep;36 Suppl 2:121-5 [16862418] Int J Cancer. 2006 Nov 1;119(9):2001-6 [16642469] J Natl Cancer Inst. 2007 Jan 3;99(1):24-31 [17202110] J Med Genet. 2007 Feb;44(2):81-8 [17105749] Ann Neurol. 2007 Mar;61(3):189-98 [17387725] Int J Cancer. 2007 Nov 15;121(10):2233-40 [17557301] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] J Natl Cancer Inst. 2008 Mar 19;100(6):428-36 [18334707] JAMA. 2008 Mar 19;299(11):1315-9 [18349092] Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):228-35 [18571337] Otolaryngol Head Neck Surg. 2000 May;122(5):667-72 [10793343] J Pediatr Hematol Oncol. 2001 Oct;23(7):431-6 [11878577] J Med Genet. 2002 May;39(5):311-4 [12011145] Nat Rev Cancer. 2002 Feb;2(2):124-32 [12635175] Proc Natl Acad Sci U S A. 1971 Apr;68(4):820-3 [5279523] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00247-008-1015-6 ER - TY - JOUR T1 - Children's exposure to diagnostic medical radiation and cancer risk: epidemiologic and dosimetric considerations. AN - 66799744; 19083224 AB - While the etiology of most childhood cancers is largely unknown, epidemiologic studies have consistently found an association between exposure to medical radiation during pregnancy and risk of childhood cancer in offspring. The relation between early life diagnostic radiation exposure and occurrence of pediatric cancer risks is less clear. This review summarizes current and historical estimated doses for common diagnostic radiologic procedures as well as the epidemiologic literature on the role of maternal prenatal, children's postnatal and parental preconception diagnostic radiologic procedures on subsequent risk of childhood malignancies. Risk estimates are presented according to factors such as the year of birth of the child, trimester and medical indication for the procedure, and the number of films taken. The paper also discusses limitations of the methods employed in epidemiologic studies to assess pediatric cancer risks, the effects on clinical practice of the results reported from the epidemiologic studies, and clinical and public health policy implications of the findings. Gaps in understanding and additional research needs are identified. Important research priorities include nationwide surveys to estimate fetal and childhood radiation doses from common diagnostic procedures, and epidemiologic studies to quantify pediatric and lifetime cancer risks from prenatal and early childhood exposures to diagnostic radiography, CT, and fluoroscopically guided procedures. JF - Pediatric radiology AU - Linet, Martha S AU - Kim, Kwang Pyo AU - Rajaraman, Preetha AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7238, USA. linetm@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - S4 EP - 26 VL - 39 Suppl 1 SN - 0301-0449, 0301-0449 KW - Index Medicus KW - Risk KW - Radiation Dosage KW - Tomography, X-Ray Computed -- adverse effects KW - Humans KW - Child KW - Radionuclide Imaging -- adverse effects KW - Female KW - Pregnancy KW - Fetus -- radiation effects KW - Neoplasms, Radiation-Induced -- etiology KW - Radiography -- adverse effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66799744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+radiology&rft.atitle=Children%27s+exposure+to+diagnostic+medical+radiation+and+cancer+risk%3A+epidemiologic+and+dosimetric+considerations.&rft.au=Linet%2C+Martha+S%3BKim%2C+Kwang+Pyo%3BRajaraman%2C+Preetha&rft.aulast=Linet&rft.aufirst=Martha&rft.date=2009-02-01&rft.volume=39+Suppl+1&rft.issue=&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=Pediatric+radiology&rft.issn=03010449&rft_id=info:doi/10.1007%2Fs00247-008-1026-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2009-01-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1990 Sep 15;46(3):362-5 [2394502] Tumori. 1990 Oct 31;76(5):413-9 [2256184] Eur J Nucl Med. 1990;17(3-4):127-9 [2279492] BMJ. 1993 Mar 6;306(6878):615-21 [8461811] Bol Med Hosp Infant Mex. 1993 Apr;50(4):248-57 [8471171] Cancer Epidemiol Biomarkers Prev. 1992 Nov-Dec;1(7):525-32 [1302564] Am J Epidemiol. 1993 May 15;137(10):1068-80 [8317436] Cancer. 1993 Aug 1;72(3):938-44 [8392906] Radiat Res. 1994 Feb;137(2 Suppl):S68-97 [8127953] Cancer Epidemiol Biomarkers Prev. 1994 Apr-May;3(3):197-204 [8019366] Br J Cancer. 1994 Sep;70(3):531-6 [8080742] Cancer Epidemiol Biomarkers Prev. 1994 Sep;3(6):457-60 [8000294] JAMA. 1995 Aug 2;274(5):402-7 [7616636] Br J Obstet Gynaecol. 1995 Oct;102(10):831-2 [7547742] N Engl J Med. 1996 Mar 21;334(12):745-51 [8592547] Environ Health Perspect. 1995 Nov;103(11):1018-25 [8605850] Br Med Bull. 1996 Oct;52(4):682-703 [9039726] Br J Radiol. 1997 Feb;70:130-9 [9135438] Ultrasound Med Biol. 1997;23(4):481-552 [9232763] Health Phys. 1997 Nov;73(5):756-69 [9378651] Toxicol Lett. 1998 Dec 28;102-103:227-34 [10022258] Teratology. 1999 Apr;59(4):227-33 [10331524] Br Dent J. 1999 Apr 24;186(8):392-6 [10365461] Nucl Med Commun. 1999 Jun;20(6):569-73 [10451870] Lancet. 1956 Sep 1;271(6940):447 [13358242] Br J Radiol. 1957 Jun;30(354):286-90 [13426514] Br J Radiol. 1957 Jun;30(354):291-4 [13426515] Br Med J. 1958 Jun 28;1(5086):1495-508 [13546604] Am J Roentgenol Radium Ther Nucl Med. 1958 Oct;80(4):696-706 [13583304] J Chronic Dis. 1965 Feb;18:113-32 [14258467] J Natl Cancer Inst. 1962 May;28:1173-91 [14468031] Cancer. 2005 Apr 1;103(7):1457-67 [15712273] J Natl Cancer Inst. 2005 May 18;97(10):724-32 [15900042] Lancet. 2005 Jun 11-17;365(9476):2014-23 [15950715] Emerg Med J. 2005 Aug;22(8):541-3 [16046751] AJR Am J Roentgenol. 2006 Mar;186(3):871-6 [16498123] Pediatr Radiol. 2006 Jun;36(6):485-90 [16552588] Radiat Med. 2006 Oct;24(8):560-7 [17041792] J Natl Cancer Inst. 2006 Nov 1;98(21):1528-37 [17077355] J Clin Endocrinol Metab. 2006 Nov;91(11):4344-51 [16912122] Br J Radiol. 2007 Mar;80(951):177-85 [16916806] Emerg Radiol. 2007 Sep;14(4):227-32 [17505849] Radiat Res. 2007 Jul;168(1):1-64 [17722996] N Engl J Med. 2007 Nov 29;357(22):2277-84 [18046031] Health Phys. 2008 Mar;94(3):211-27 [18301095] Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):605-13 [18349278] J Natl Cancer Inst. 2008 Mar 19;100(6):428-36 [18334707] Radiat Environ Biophys. 2008 Jul;47(3):301-12 [18528700] Br J Radiol. 1999 Aug;72(860):773-80 [10624343] Environ Health Perspect. 2000 Jun;108(6):495-8 [10856021] J Radiol Prot. 2000 Dec;20(4):353-9 [11140709] Med Pediatr Oncol. 2001 Feb;36(2):274-82 [11452935] Radiat Res. 2001 Dec;156(6):718-23 [11741495] Cancer Epidemiol Biomarkers Prev. 2002 Feb;11(2):177-85 [11867505] Am J Epidemiol. 2003 Apr 1;157(7):652-63 [12672685] Acad Radiol. 2003 Apr;10(4):379-85 [12678177] Epidemiology. 2003 Jul;14(4):437-41 [12843769] AJR Am J Roentgenol. 2003 Aug;181(2):321-9 [12876005] Eur Radiol. 2003 Aug;13(8):1979-91 [12687286] Ann ICRP. 2003;33(1-2):5-206 [12963090] Natl Cancer Inst Monogr. 1966 Jan;19:347-71 [5905674] Br J Radiol. 1969 Nov;42(503):814-7 [5377677] Lancet. 1971 Jan 2;1(7688):42-3 [4099349] Int J Cancer. 1975 Jun 15;15(6):941-6 [1150348] Br J Cancer. 1975 Mar;31(3):271-87 [1156514] Lancet. 1976 Feb 14;1(7955):351-2 [54754] Lancet. 1978 Dec 16;2(8103):1293-6 [82793] Am J Epidemiol. 1979 Mar;109(3):309-19 [453168] Br J Cancer. 1980 Feb;41(2):222-6 [7370161] J Natl Cancer Inst. 1980 Jul;65(1):67-73 [6930521] J Natl Cancer Inst. 1980 Oct;65(4):681-6 [6932521] Radiology. 1980 Oct;137(1 Pt 1):258-9 [7422856] Health Phys. 1981 Apr;40(4):511-24 [7228702] Br J Cancer. 1982 Apr;45(4):543-51 [6951601] Cancer Res. 1982 Dec;42(12):5240-5 [7139628] Lancet. 1984 Nov 3;2(8410):997-9 [6149439] Lancet. 1984 Nov 3;2(8410):999-1000 [6149440] N Engl J Med. 1985 Feb 28;312(9):541-5 [3969117] Int J Epidemiol. 1985 Dec;14(4):555-9 [3866751] Acta Pathol Microbiol Immunol Scand Suppl. 1986;288:1-151 [3465196] Cancer Res. 1987 Jun 1;47(11):2972-7 [3032418] J Natl Cancer Inst. 1987 May;78(5):797-804 [3471992] Cancer. 1988 Aug 1;62(3):635-44 [3164642] Stat Med. 1988 Aug;7(8):857-64 [3413365] N Engl J Med. 1988 Oct 20;319(16):1033-9 [3173432] J Epidemiol Community Health. 1988 Sep;42(3):235-42 [3251004] Cancer Res. 1989 Jul 15;49(14):4030-7 [2736544] Cancer Res. 1989 Aug 1;49(15):4349-52 [2743324] J Natl Cancer Inst. 1989 Sep 6;81(17):1307-12 [2769783] Tumori. 1989 Aug 31;75(4):396-400 [2815346] Br J Cancer. 1990 Jul;62(1):152-68 [2202420] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00247-008-1026-3 ER - TY - JOUR T1 - Raft aggregation with specific receptor recruitment is required for microglial phagocytosis of Abeta42. AN - 66741201; 18756527 AB - Microglial phagocytosis contributes to the maintenance of brain homeostasis. Mechanisms involved, however, remain unclear. Using Abeta(42) solely as a stimulant, we provide novel insight into regulation of microglial phagocytosis by rafts. We demonstrate the existence of an Abeta(42) threshold level of 250 pg/mL, above which microglial phagocytic function is impaired. Low levels of Abeta(42) facilitate fluorescent bead uptake, whereas phagocytosis is inhibited when Abeta(42) accumulates. We also show that region-specific raft clustering occurs before microglial phagocytosis. Low Abeta(42) levels stimulated this type of raft aggregation, but high Abeta(42) levels inhibited it. Additionally, treatment with high Abeta(42) concentrations caused a redistribution of the raft structural protein flotillin1 from low to higher density fractions along a sucrose gradient. This suggests a loss of raft structural integrity. Certain non-steroidal anti-inflammatory drugs, e.g., the cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs, celecoxib, raise Abeta(42) levels. We demonstrated that prolonged celecoxib exposure can disrupt rafts in a manner similar to that seen in an elevated Abeta(42) environment: abnormal raft aggregation and Flot1 distribution. This resulted in aberrant receptor recruitment to rafts and impaired receptor-mediated phagocytosis by microglial cells. Specifically, recruitment of the scavenger receptor CD36 to rafts during active phagocytosis was affected. Thus, we propose that maintaining raft integrity is crucial for determining microglial phagocytic outcomes and disease progression. JF - Glia AU - Persaud-Sawin, Dixie-Ann AU - Banach, Lynna AU - Harry, Gaylia Jean AD - Laboratory of Neurobiology, Neurotoxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. sawind@niehs.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 320 EP - 335 VL - 57 IS - 3 KW - Amyloid beta-Peptides KW - 0 KW - Antigens, CD36 KW - Antigens, CD47 KW - Cyclooxygenase Inhibitors KW - Membrane Proteins KW - Peptide Fragments KW - Pyrazoles KW - Sulfonamides KW - amyloid beta-protein (1-42) KW - flotillins KW - Amyloid Precursor Protein Secretases KW - EC 3.4.- KW - Celecoxib KW - JCX84Q7J1L KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Analysis of Variance KW - Rats, Long-Evans KW - Dose-Response Relationship, Drug KW - Protein Transport -- drug effects KW - Membrane Proteins -- metabolism KW - Mice KW - Amyloid Precursor Protein Secretases -- metabolism KW - Cyclooxygenase Inhibitors -- pharmacology KW - Rats KW - Pyrazoles -- pharmacology KW - Phagocytosis -- physiology KW - Animals, Newborn KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Sulfonamides -- pharmacology KW - Cells, Cultured KW - Antigens, CD47 -- genetics KW - Antigens, CD47 -- metabolism KW - Peptide Fragments -- metabolism KW - Antigens, CD36 -- metabolism KW - Membrane Microdomains -- metabolism KW - Amyloid beta-Peptides -- metabolism KW - Antigens, CD36 -- genetics KW - Peptide Fragments -- pharmacology KW - Microglia -- cytology KW - Amyloid beta-Peptides -- pharmacology KW - Membrane Microdomains -- drug effects KW - Microglia -- drug effects KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66741201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=Raft+aggregation+with+specific+receptor+recruitment+is+required+for+microglial+phagocytosis+of+Abeta42.&rft.au=Persaud-Sawin%2C+Dixie-Ann%3BBanach%2C+Lynna%3BHarry%2C+Gaylia+Jean&rft.aulast=Persaud-Sawin&rft.aufirst=Dixie-Ann&rft.date=2009-02-01&rft.volume=57&rft.issue=3&rft.spage=320&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=1098-1136&rft_id=info:doi/10.1002%2Fglia.20759 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-28 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Discov Today. 2006 Oct;11(19-20):931-8 [16997144] J Biol Chem. 2006 Oct 13;281(41):31002-11 [16880211] Brain. 2006 Nov;129(Pt 11):3006-19 [16984903] J Surg Res. 2006 Nov;136(1):58-69 [16979664] Biochem Biophys Res Commun. 2006 Dec 8;351(1):51-6 [17052693] Biochem Biophys Res Commun. 2006 Dec 8;351(1):246-52 [17056010] Curr Pharm Des. 2006;12(33):4337-55 [17105431] Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18787-92 [17116874] Glia. 2007 Mar;55(4):412-24 [17203473] Brain Res Rev. 2007 Feb;53(2):344-54 [17188751] J Immunol. 2007 May 1;178(9):5635-42 [17442946] Cell Biol Int. 2007 May;31(5):508-15 [17196403] FEBS Lett. 2007 May 1;581(9):1783-7 [17428477] Nature. 2007 Apr 26;446(7139):1091-5 [17410128] Mol Cancer Ther. 2007 Jun;6(6):1745-54 [17541035] Glia. 2007 Aug 1;55(10):1023-33 [17549683] Mol Pharmacol. 2007 Jul;72(1):141-51 [17395689] Nat Cell Biol. 2007 Aug;9(8):905-14 [17618274] Eur J Cell Biol. 2007 Sep;86(9):525-32 [17482313] J Biol Chem. 2007 Sep 14;282(37):27392-401 [17623670] Nat Protoc. 2007;2(9):2159-65 [17853872] J Cell Sci. 2007 Dec 1;120(Pt 23):4081-91 [18032783] Dev Neurobiol. 2008 Feb 1;68(2):195-208 [18000830] Neurobiol Aging. 2008 Jun;29(6):795-811 [17313996] Glia. 2008 Aug 15;56(11):1215-23 [18449945] Nat Med. 2001 May;7(5):612-8 [11329064] J Biol Chem. 1999 Nov 5;274(45):32301-8 [10542270] Mol Cell Neurosci. 2005 Jul;29(3):381-93 [15890528] J Alzheimers Dis. 2005 Jun;7(3):221-32; 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quiz 988 [16675322] Nat Rev Mol Cell Biol. 2006 Jun;7(6):456-62 [16625153] IUBMB Life. 2006 May-Jun;58(5-6):304-8 [16754322] Curr Med Chem. 2006;13(16):1903-13 [16842201] Trends Neurosci. 2006 Sep;29(9):506-10 [16859761] J Immunol. 2006 Sep 15;177(6):4047-54 [16951368] Apoptosis. 2006 Oct;11(10):1709-26 [16951923] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/glia.20759 ER - TY - JOUR T1 - Do Men and Women with HIV Differ in Their Quality of Life? A Study from South India AN - 61419104; 200901650 AB - This paper examined gender differences in Quality of Life (QOL) among people living with HIV/AIDS in South India using the locally validated version of the WHO Quality of Life Instrument for HIV (WHOQOL-HIV 120). Participants (N = 109) were men and women with HIV1 Clade C infection participating in a cohort study. There was no gender difference in CD4 counts or use of antiretroviral therapy. Of the 29 facets of QOL, men reported significantly higher QOL in the following facets-positive feeling, sexual activity, financial resources and transport, while women reported significantly higher QOL on the forgiveness and blame facet. Of the six domains of QOL, men reported better quality of life in the environmental domain while women had higher scores on the spirituality/religion and personal beliefs domain. Understanding these gender differences may provide potentially useful information for tailoring interventions to enhance QOL among people infected with HIV/AIDS. Adapted from the source document. JF - AIDS and Behavior AU - Chandra, Prabha S AU - Satyanarayana, Veena A AU - Satishchandra, P AU - Satish, K S AU - Kumar, Mahendra AD - Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, 560029, India chandra@nimhans.kar.nic.in Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 110 EP - 117 PB - Springer, Dordrecht, The Netherlands VL - 13 IS - 1 SN - 1090-7165, 1090-7165 KW - Acquired Immune Deficiency Syndrome KW - Medications KW - Sex Differences KW - Quality of Life KW - India KW - Sex KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61419104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Do+Men+and+Women+with+HIV+Differ+in+Their+Quality+of+Life%3F+A+Study+from+South+India&rft.au=Chandra%2C+Prabha+S%3BSatyanarayana%2C+Veena+A%3BSatishchandra%2C+P%3BSatish%2C+K+S%3BKumar%2C+Mahendra&rft.aulast=Chandra&rft.aufirst=Prabha&rft.date=2009-02-01&rft.volume=13&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-008-9434-9 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 39 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Quality of Life; Sex; Sex Differences; India; Medications DO - http://dx.doi.org/10.1007/s10461-008-9434-9 ER - TY - JOUR T1 - How to Interpret PubMed Queries and Why it Matters AN - 57739051; 200903881 AB - A significant fraction of queries in PubMed are multiterm queries without parsing instructions. Generally, search engines interpret such queries as collections of terms, and handle them as a Boolean conjunction of these terms. However, analysis of queries in PubMed indicates that many such queries are meaningful phrases, rather than simple collections of terms. In this study, we examine whether or not it makes a difference, in terms of retrieval quality, if such queries are interpreted as a phrase or as a conjunction of query terms. And, if it does, what is the optimal way of searching with such queries. To address the question, we developed an automated retrieval evaluation method, based on machine learning techniques, that enables us to evaluate and compare various retrieval outcomes. We show that the class of records that contain all the search terms, but not the phrase, qualitatively differs from the class of records containing the phrase. We also show that the difference is systematic, depending on the proximity of query terms to each other within the record. Based on these results, one can establish the best retrieval order for the records. Our findings are consistent with studies in proximity searching. [Copyright 2009 Wiley Periodicals Inc.] JF - Journal of the American Society for Information Science and Technology AU - Yeganova, Lana AU - Comeau, Donald C AU - Kim, Won AU - Wilbur, W John AD - Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38A, 8600 Rockville Pike, Bethesda, MD 20894 yeganova@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - 264 EP - 274 PB - Wiley Subscription Services, Hoboken NJ VL - 60 IS - 2 SN - 1532-2882, 1532-2882 KW - Online data bases KW - Online information retrieval KW - article KW - 13.14: INFORMATION STORAGE AND RETRIEVAL - SEARCHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57739051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Relationship+of+p53+Overexpression+on+Cancers+and+Recognition+by+Anti-p53+T+Cell+Receptor-Transduced+T+Cells&rft.au=Theoret%2C+M+R%3BCohen%2C+C+J%3BNahvi%2C+A+V%3BNgo%2C+L+T%3BSuri%2C+K+B%3BPowell%2C+DJ+Jr%3BDudley%2C+ME%3BMorgan%2C+R+A%3BRosenberg%2C+SA&rft.aulast=Theoret&rft.aufirst=M&rft.date=2008-11-01&rft.volume=19&rft.issue=11&rft.spage=1219&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.083 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Online information retrieval; Online data bases ER - TY - JOUR T1 - Solution-Oriented Research: Converging Efforts of Promoting Environmental Sustainability and Obesity Prevention AN - 57281898; 200906394 AB - Given trends from the last 30 years, the most recent projection estimates that the U.S. prevalence of obesity, not counting the rate of overweight, will reach 51% among adults and 30% among youth by 2030. Total healthcare costs attributable to overweight and obesity will double every decade reaching 861-957 billion dollars a year, or 16-18 percent of the total U.S. healthcare expenditure. In light of these dire predictions, a new multilevel research paradigm has recently been proposed to transform efforts to produce effective and sustainable solutions in the long term. [Copyright 2009 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Huang, Terry T-K AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland huangter@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - February 2009 SP - S60 EP - S62 PB - Elsevier Science, New York NY VL - 36 IS - 2S1 SN - 0749-3797, 0749-3797 KW - Health costs KW - Obesity KW - Physical activity KW - Preventive programmes KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Solution-Oriented+Research%3A+Converging+Efforts+of+Promoting+Environmental+Sustainability+and+Obesity+Prevention&rft.au=Huang%2C+Terry+T-K&rft.aulast=Huang&rft.aufirst=Terry&rft.date=2009-02-01&rft.volume=36&rft.issue=2S1&rft.spage=S60&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2008.11.002 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Obesity; Health promotion; Health costs; Preventive programmes; Physical activity DO - http://dx.doi.org/10.1016/j.amepre.2008.11.002 ER - TY - CPAPER T1 - Short Talk: Neonatal Genistein Exposure Disrupts Adult Female Reproductive Tract Support of Preimplantation Embryo Development and Implantation T2 - 2009 Keystone Symposia on Frontiers in Reproductive Biology and Regulation of Fertility (B5) AN - 41952626; 5113747 JF - 2009 Keystone Symposia on Frontiers in Reproductive Biology and Regulation of Fertility (B5) AU - Williams, Carmen Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 KW - Embryonic development KW - Neonates KW - Reproductive system KW - Genistein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41952626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Frontiers+in+Reproductive+Biology+and+Regulation+of+Fertility+%28B5%29&rft.atitle=Short+Talk%3A+Neonatal+Genistein+Exposure+Disrupts+Adult+Female+Reproductive+Tract+Support+of+Preimplantation+Embryo+Development+and+Implantation&rft.au=Williams%2C+Carmen&rft.aulast=Williams&rft.aufirst=Carmen&rft.date=2009-02-01&rft.volume=27&rft.issue=6&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2F0278-6133.27.6.703 L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=97 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinically Inapparent but Immunologically Measurable Bystander Effects of Tissue-Invasive Helminth Infections on other Infectious Diseases of Humans T2 - 2009 Keystone Symposia on Pathogenesis and Immune Regulation in Helminth Infections (B4) AN - 41912148; 5114738 JF - 2009 Keystone Symposia on Pathogenesis and Immune Regulation in Helminth Infections (B4) AU - Nutman, Thomas Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 KW - Infectious diseases KW - Helminths KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41912148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Pathogenesis+and+Immune+Regulation+in+Helminth+Infections+%28B4%29&rft.atitle=Clinically+Inapparent+but+Immunologically+Measurable+Bystander+Effects+of+Tissue-Invasive+Helminth+Infections+on+other+Infectious+Diseases+of+Humans&rft.au=Nutman%2C+Thomas&rft.aulast=Nutman&rft.aufirst=Thomas&rft.date=2009-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Pathogenesis+and+Immune+Regulation+in+Helminth+Infections+%28B4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissecting "Alternative" Activation: The Role of Macrophages and Other Targets of IL-4/IL-13 Signaling T2 - 2009 Keystone Symposia on Pathogenesis and Immune Regulation in Helminth Infections (B4) AN - 41906361; 5114761 JF - 2009 Keystone Symposia on Pathogenesis and Immune Regulation in Helminth Infections (B4) AU - Wynn, Thomas Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 KW - Signal transduction KW - Macrophages KW - Interleukin 13 KW - Cell activation KW - Interleukin 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41906361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Pathogenesis+and+Immune+Regulation+in+Helminth+Infections+%28B4%29&rft.atitle=Dissecting+%22Alternative%22+Activation%3A+The+Role+of+Macrophages+and+Other+Targets+of+IL-4%2FIL-13+Signaling&rft.au=Wynn%2C+Thomas&rft.aulast=Wynn&rft.aufirst=Thomas&rft.date=2009-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Pathogenesis+and+Immune+Regulation+in+Helminth+Infections+%28B4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evolving Paradigms of Sperm-Egg Recognition in Mouse Fertilization T2 - 2009 Keystone Symposia on Frontiers in Reproductive Biology and Regulation of Fertility (B5) AN - 41901428; 5113733 JF - 2009 Keystone Symposia on Frontiers in Reproductive Biology and Regulation of Fertility (B5) AU - Dean, Jurrien Y1 - 2009/02/01/ PY - 2009 DA - 2009 Feb 01 KW - Fertilization KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41901428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Frontiers+in+Reproductive+Biology+and+Regulation+of+Fertility+%28B5%29&rft.atitle=Evolving+Paradigms+of+Sperm-Egg+Recognition+in+Mouse+Fertilization&rft.au=Dean%2C+Jurrien&rft.aulast=Dean&rft.aufirst=Jurrien&rft.date=2009-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Frontiers+in+Reproductive+Biology+and+Regulation+of+Fertility+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=97 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Distinct Domains within APOBEC3G and APOBEC3F Interact with Separate Regions of Human Immunodeficiency Virus Type 1 Vif AN - 21490286; 12493891 AB - Human APOBEC3G (A3G) and APOBEC3F (A3F) inhibit the replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host restriction factors by binding to them and inducing their degradation. Thus, the Vif-A3G and Vif-A3F interactions are attractive targets for antiviral drug development, as inhibiting these interactions could allow the host defense mechanism to control HIV-1 replication. Recently, it has been reported that amino acids 105 to 156 of A3G are involved in the interaction with Vif; however, to date, the region of A3F involved in Vif binding has not been identified. Using our previously reported Vif mutants that are capable of binding to only A3G (3G binder) or only A3F (3F binder), in conjunction with a series of A3G-A3F chimeras, we have now mapped the APOBEC3-Vif interaction domains. We found that the A3G domain that interacts with the Vif YRHHY region is located between amino acids 126 and 132 of A3G, which is consistent with the conclusions reported in previous studies. The A3F domain that interacts with the Vif DRMR region did not occur in the homologous domain but instead was located between amino acids 283 and 300 of A3F. These studies are the first to identify the A3F domain that interacts with the Vif DRMR region and show that distinct domains of A3G and A3F interact with different Vif regions. Pharmacological inhibition of either or both of these Vif-A3 interactions should prevent the degradation of the APOBEC3 proteins and could be used as a therapy against HIV-1. JF - Journal of Virology AU - Russell, Rebecca A AU - Smith, Jessica AU - Barr, Rebekah AU - Bhattacharyya, Darshana AU - Pathak, Vinay K AD - Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, vpathak@ncifcrf.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1992 EP - 2003 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 4 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Chimeras KW - Amino acids KW - Replication KW - Human immunodeficiency virus 1 KW - Drug development KW - Defense mechanisms KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21490286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Distinct+Domains+within+APOBEC3G+and+APOBEC3F+Interact+with+Separate+Regions+of+Human+Immunodeficiency+Virus+Type+1+Vif&rft.au=Russell%2C+Rebecca+A%3BSmith%2C+Jessica%3BBarr%2C+Rebekah%3BBhattacharyya%2C+Darshana%3BPathak%2C+Vinay+K&rft.aulast=Russell&rft.aufirst=Rebecca&rft.date=2009-02-01&rft.volume=83&rft.issue=4&rft.spage=1992&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01621-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Chimeras; Amino acids; Replication; Drug development; Defense mechanisms; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.01621-08 ER - TY - JOUR T1 - Comparative Genomics Reveal Extensive Transposon-Mediated Genomic Plasticity and Diversity among Potential Effector Proteins within the Genus Coxiella , AN - 21293382; 12511065 AB - Genetically distinct isolates of Coxiella burnetii, the cause of human Q fever, display different phenotypes with respect to in vitro infectivity/cytopathology and pathogenicity for laboratory animals. Moreover, correlations between C. burnetii genomic groups and human disease presentation (acute versus chronic) have been described, suggesting that isolates have distinct virulence characteristics. To provide a more-complete understanding of C. burnetii's genetic diversity, evolution, and pathogenic potential, we deciphered the whole-genome sequences of the K (Q154) and G (Q212) human chronic endocarditis isolates and the naturally attenuated Dugway (5J108-111) rodent isolate. Cross-genome comparisons that included the previously sequenced Nine Mile (NM) reference isolate (RSA493) revealed both novel gene content and disparate collections of pseudogenes that may contribute to isolate virulence and other phenotypes. While C. burnetii genomes are highly syntenous, recombination between abundant insertion sequence (IS) elements has resulted in genome plasticity manifested as chromosomal rearrangement of syntenic blocks and DNA insertions/deletions. The numerous IS elements, genomic rearrangements, and pseudogenes of C. burnetii isolates are consistent with genome structures of other bacterial pathogens that have recently emerged from nonpathogens with expanded niches. The observation that the attenuated Dugway isolate has the largest genome with the fewest pseudogenes and IS elements suggests that this isolate's lineage is at an earlier stage of pathoadaptation than the NM, K, and G lineages. JF - Infection and Immunity AU - Beare, Paul A AU - Unsworth, Nathan AU - Andoh, Masako AU - Voth, Daniel E AU - Omsland, Anders AU - Gilk, Stacey D AU - Williams, Kelly P AU - Sobral, Bruno W AU - Kupko III, John J AU - Porcella, Stephen F AU - Samuel, James E AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, rheinzen@niaid.nih.gov rheinzen@niaid.nih.gov rheinzen@niaid.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 642 EP - 656 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 2 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Chromosome deletion KW - Chromosome rearrangements KW - DNA KW - Endocarditis KW - Evolution KW - Genetic diversity KW - Infectivity KW - Insertion KW - Insertion sequences KW - Laboratory animals KW - Niches KW - Nucleotide sequence KW - Pathogenicity KW - Pathogens KW - Pseudogenes KW - Q fever KW - Recombination KW - Synteny KW - Virulence KW - genomics KW - Coxiella burnetii KW - J 02350:Immunology KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21293382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Comparative+Genomics+Reveal+Extensive+Transposon-Mediated+Genomic+Plasticity+and+Diversity+among+Potential+Effector+Proteins+within+the+Genus+Coxiella+%2C&rft.au=Beare%2C+Paul+A%3BUnsworth%2C+Nathan%3BAndoh%2C+Masako%3BVoth%2C+Daniel+E%3BOmsland%2C+Anders%3BGilk%2C+Stacey+D%3BWilliams%2C+Kelly+P%3BSobral%2C+Bruno+W%3BKupko+III%2C+John+J%3BPorcella%2C+Stephen+F%3BSamuel%2C+James+E%3BHeinzen%2C+Robert+A&rft.aulast=Beare&rft.aufirst=Paul&rft.date=2009-02-01&rft.volume=77&rft.issue=2&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01141-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Pseudogenes; Synteny; Nucleotide sequence; Niches; Laboratory animals; Genetic diversity; Pathogens; Insertion sequences; Endocarditis; Virulence; Recombination; Infectivity; Pathogenicity; Insertion; Chromosome rearrangements; Chromosome deletion; DNA; genomics; Q fever; Evolution; Coxiella burnetii DO - http://dx.doi.org/10.1128/IAI.01141-08 ER - TY - JOUR T1 - Multiple ways of targeting APOBEC3-virion infectivity factor interactions for anti-HIV-1 drug development AN - 21049123; 11314646 AB - HIV-1 infections and the resulting AIDS pandemic remain a global challenge in the absence of a protective vaccine and because of rapid selection of drug-resistant viral variants in response to all currently available antiviral therapies. The development of new and highly active antiviral agents would greatly facilitate effective clinical management of HIV-1 infections and delay the onset of AIDS. Recent advances in our understanding of intracellular immunity conferred by host cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) and the mechanism by which the virally encoded virion infectivity factor (Vif) protein induces their proteasomal degradation provide fresh opportunities for the development of novel antiviral treatments. Interestingly, the Vif-A3G and Vif-A3F interactions that overcome this host defense mechanism are structurally distinct and provide two potential targets for antiviral drug development. This review provides an overview of current knowledge of APOBEC3-Vif interactions and recent efforts to target these interactions for antiviral drug development. JF - Trends in Pharmacological Sciences AU - Smith, Jessica L AU - Bu, Wei AU - Burdick, Ryan C AU - Pathak, Vinay K AD - Viral Mutation Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA, vinay.pathak@nih.gov PY - 2009 SP - 638 EP - 646 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 30 IS - 12 SN - 0165-6147, 0165-6147 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Virions KW - Acquired immune deficiency syndrome KW - Drug resistance KW - proteasomes KW - Drug development KW - Immunity KW - Infection KW - pandemics KW - Infectivity KW - Antiviral agents KW - Reviews KW - Human immunodeficiency virus 1 KW - Vif protein KW - Defense mechanisms KW - Vaccines KW - Cytidine deaminase KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21049123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Development+of+optimal+bicistronic+lentiviral+vectors+facilitates+high-+level+TCR+gene+expression+and+robust+tumor+cell+recognition&rft.au=Yang%2C+S%3BCohen%2C+C+J%3BPeng%2C+P+D%3BZhao%2C+Y%3BCassard%2C+L%3BYu%2C+Z%3BZheng%2C+Z%3BJones%2C+S%3BRestifo%2C+N+P%3BRosenberg%2C+S+A%3BMorgan%2C+R+A&rft.aulast=Yang&rft.aufirst=S&rft.date=2008-11-01&rft.volume=15&rft.issue=21&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2008.90 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Virions; Acquired immune deficiency syndrome; Drug resistance; proteasomes; Drug development; Immunity; Infection; Infectivity; pandemics; Antiviral agents; Reviews; Vif protein; Vaccines; Defense mechanisms; Cytidine deaminase; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.tips.2009.09.006 ER - TY - JOUR T1 - Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma AN - 20626428; 9356131 AB - Diagnosis and treatment of cervical cancer precursors rely on colposcopic biopsy, which is sometimes hampered by incorrect biopsy placement and the unclear prognostic value of poorly reproducible diagnoses such as cervical intraepithelial neoplasia (CIN) Grade 1 and 2. Searching for discrete disease categories that incorporate the value of cytology and that reflect the causal role of particular HPV types, we analyzed histology, cytology and HPV genotype distributions in the Study to Understand Cervical Cancer Endpoints and Early Determinants (SUCCEED). This cross-sectional study comprises 1,700 women referred to colposcopy or treatment for the spectrum of cervical disease, including 439 women with 13 million nucleotides with run times of 5 to 96 h. GADEM can be viewed as an extension of the well-known MEME algorithm and is an efficient tool for de novo motif discovery in large-scale genome-wide data. JF - Journal of Computational Biology AU - Li, L AD - Biostatistics Branch National Institute of Environmental Health Sciences NIH Research Triangle Park, NC 27709, li3@niehs.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 317 EP - 329 VL - 16 IS - 2 SN - 1066-5277, 1066-5277 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Nucleotide sequence KW - Algorithms KW - Statistical analysis KW - Computer applications KW - Entropy KW - Nucleotides KW - Evolution KW - p53 protein KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20399469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=GADEM%3A+A+Genetic+Algorithm+Guided+Formation+of+Spaced+Dyads+Coupled+with+an+EM+Algorithm+for+Motif+Discovery&rft.au=Li%2C+L&rft.aulast=Li&rft.aufirst=L&rft.date=2009-02-01&rft.volume=16&rft.issue=2&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=10665277&rft_id=info:doi/10.1089%2Fcmb.2008.16TT LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Nucleotide sequence; Statistical analysis; Algorithms; Computer applications; Evolution; Nucleotides; Entropy; p53 protein DO - http://dx.doi.org/10.1089/cmb.2008.16TT ER - TY - JOUR T1 - Defining Developmental Potency and Cell Lineage Trajectories by Expression Profiling of Differentiating Mouse Embryonic Stem Cells AN - 20397985; 9069683 AB - Biologists rely on morphology, function and specific markers to define the differentiation status of cells. Transcript profiling has expanded the repertoire of these markers by providing the snapshot of cellular status that reflects the activity of all genes. However, such data have been used only to assess relative similarities and differences of these cells. Here we show that principal component analysis of global gene expression profiles map cells in multidimensional transcript profile space and the positions of differentiating cells progress in a stepwise manner along trajectories starting from undifferentiated embryonic stem (ES) cells located in the apex. We present three 'cell lineage trajectories', which represent the differentiation of ES cells into the first three lineages in mammalian development: primitive endoderm, trophoblast and primitive ectoderm/neural ectoderm. The positions of the cells along these trajectories seem to reflect the developmental potency of cells and can be used as a scale for the potential of cells. Indeed, we show that embryonic germ cells and induced pluripotent cells are mapped near the origin of the trajectories, whereas mouse embryo fibroblast and fibroblast cell lines are mapped near the far end of the trajectories. We suggest that this method can be used as the non-operational semi-quantitative definition of cell differentiation status and developmental potency. Furthermore, the global expression profiles of cell lineages provide a framework for the future study of in vitro and in vivo cell differentiation. JF - DNA Research AU - Aiba, K AU - Nedorezov, T AU - Piao, Y AU - Nishiyama, A AU - Matoba, R AU - Sharova, LV AU - Sharov, A A AU - Yamanaka, S AU - Niwa, H AU - Ko, MSH AD - Developmental Genomes and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, Baltimore, MD 21224, USA, kom@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 VL - 16 IS - 1 SN - 1340-2838, 1340-2838 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Cell lineage KW - Data processing KW - Ectoderm KW - Germ cells KW - Trophoblasts KW - Transcription KW - Gene expression KW - Differentiation KW - Stem cells KW - Embryo cells KW - Principal components analysis KW - Embryo fibroblasts KW - Endoderm KW - W 30940:Products KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Research&rft.atitle=Defining+Developmental+Potency+and+Cell+Lineage+Trajectories+by+Expression+Profiling+of+Differentiating+Mouse+Embryonic+Stem+Cells&rft.au=Aiba%2C+K%3BNedorezov%2C+T%3BPiao%2C+Y%3BNishiyama%2C+A%3BMatoba%2C+R%3BSharova%2C+LV%3BSharov%2C+A+A%3BYamanaka%2C+S%3BNiwa%2C+H%3BKo%2C+MSH&rft.aulast=Aiba&rft.aufirst=K&rft.date=2009-02-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=DNA+Research&rft.issn=13402838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell lineage; Data processing; Ectoderm; Germ cells; Transcription; Trophoblasts; Gene expression; Differentiation; Stem cells; Embryo cells; Principal components analysis; Embryo fibroblasts; Endoderm ER - TY - JOUR T1 - Endocrine Pharmacology: Co-existence of muscarinic and nicotinic receptors and their functional interaction in mouse Beta-TC6 cells AN - 20397693; 9063311 AB - Mouse Beta-TC6 insulinoma cells possessing nicotinic receptor [Ohtani, M., Oka, T., Badyuk, M., Xiao, Y., Kellar, KJ., Daly, JW., 2006. Mouse b-TC6 insulinoma cells: high expression of functional a3b4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release. Mol. Pharmacol. 69, 899 -907.] also expressed M3 and M4 muscarinic receptors. Carbamylcholine, a mixed muscarinic/nicotinic receptor agonist, or oxotremorine M, a selective muscarinic agonist, elicited an elevation of cytoplasmic Ca2+ concentration ([Ca2+]i) and release of insulin. The maximal [Ca2+]i response induced by carbamylcholine was larger than that of oxotremorine M or that of nicotine, suggesting that carbamylcholine enhanced the [Ca2+]i response by stimulating two types of receptor. M3 and M4 muscarinic receptor antagonists inhibited the [Ca2+]i responses to carbamylcholine and oxotremorine M, suggesting the involvement of these muscarinic receptors in the regulation of [Ca2+]i. In addition, pretreatment with carbamylcholine inhibited the [Ca2+]i responses to oxotremorine M or nicotine, indicating that the effect of carbamylcholine on [Ca2+]i was mediated by both muscarinic and nicotinic receptors. A phospholipase C (PLC) inhibitor U73122, a protein kinase C (PKC) inhibitor chelerythrine and a phospholipase A2 (PLA2) inhibitor AACOCF3 inhibited the [Ca2+]i response to carbamylcholine or oxotremorine M, while these inhibitors did not block the effect of nicotine. Carbamylcholine induced a smaller extent of insulin secretion than oxotremorine M, suggesting that concomitant stimulation of muscarinic and nicotinic receptors by carbamylcholine resulted in the negative type of the receptor interaction. JF - European Journal of Pharmacology AU - Ohtani, Masahiro AU - Daly, John W AU - Oka, Takami AD - Chemical Biology, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, toka@musashino-u.ac.jp Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 150 EP - 157 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 604 SN - 0014-2999, 0014-2999 KW - Toxicology Abstracts; Calcium & Calcified Tissue Abstracts KW - Calcium KW - Carbamylcholine KW - Muscarinic receptor KW - Insulin secretion KW - Oxotremorine M KW - Nicotine KW - Protein kinase C KW - Pharmacology KW - Phospholipase A2 KW - Phospholipase C KW - Secretion KW - Acetylcholine receptors (muscarinic) KW - Insulinoma KW - chelerythrine KW - Antagonists KW - Insulin KW - Acetylcholine receptors (nicotinic) KW - Calcium (intracellular) KW - oxotremorine KW - Carbachol KW - Membrane potential KW - X 24310:Pharmaceuticals KW - T 2000:Cellular Calcium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Pharmacology&rft.atitle=Endocrine+Pharmacology%3A+Co-existence+of+muscarinic+and+nicotinic+receptors+and+their+functional+interaction+in+mouse+Beta-TC6+cells&rft.au=Ohtani%2C+Masahiro%3BDaly%2C+John+W%3BOka%2C+Takami&rft.aulast=Ohtani&rft.aufirst=Masahiro&rft.date=2009-02-01&rft.volume=604&rft.issue=&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Pharmacology&rft.issn=00142999&rft_id=info:doi/10.1016%2Fj.ejphar.2008.12.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Phospholipase A2; Pharmacology; Secretion; Phospholipase C; Acetylcholine receptors (muscarinic); chelerythrine; Insulinoma; Acetylcholine receptors (nicotinic); Insulin; Antagonists; Calcium (intracellular); oxotremorine; Nicotine; Carbachol; Membrane potential DO - http://dx.doi.org/10.1016/j.ejphar.2008.12.018 ER - TY - JOUR T1 - Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells AN - 20397488; 9069681 AB - Degradation of mRNA is one of the key processes that control the steady-state level of gene expression. However, the rate of mRNA decay for the majority of genes is not known. We successfully obtained the rate of mRNA decay for 19 977 non-redundant genes by microarray analysis of RNA samples obtained from mouse embryonic stem (ES) cells. Median estimated half-life was 7.1 h and only <100 genes, including Prdml, Myc, Gadd45 g, Foxa2, Hes5 and Tribl, showed half-life less than 1 h. In general, mRNA species with short half-life were enriched among genes with regulatory functions (transcription factors), whereas mRNA species with long half-life were enriched among genes related to metabolism and structure (extracellular matrix, cytoskeleton). The stability of mRNAs correlated more significantly with the structural features of genes than the function of genes: mRNA stability showed the most significant positive correlation with the number of exon junctions per open reading frame length, and negative correlation with the presence of PUF-binding motifs and AU-rich elements in 3'-untranslated region (UTR) and CpG di-nucleotides in the 5'-UTR. The mRNA decay rates presented in this report are the largest data set for mammals and the first for ES cells. JF - DNA Research AU - Sharova, LV AU - Sharov, A A AU - Nedorezov, T AU - Piao, Y AU - Shaik, N AU - Ko, MSH AD - Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, NIH, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA, KoM@grc.nia.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 VL - 16 IS - 1 SN - 1340-2838, 1340-2838 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - mRNA stability KW - mRNA turnover KW - Data processing KW - 3' Untranslated regions KW - GADD45 protein KW - Exons KW - CpG islands KW - DNA microarrays KW - Cytoskeleton KW - Myc protein KW - Databases KW - Stem cells KW - Embryo cells KW - Transcription factors KW - Extracellular matrix KW - Metabolism KW - Open reading frames KW - W 30910:Imaging KW - G 07870:Mammals KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Research&rft.atitle=Database+for+mRNA+Half-Life+of+19+977+Genes+Obtained+by+DNA+Microarray+Analysis+of+Pluripotent+and+Differentiating+Mouse+Embryonic+Stem+Cells&rft.au=Sharova%2C+LV%3BSharov%2C+A+A%3BNedorezov%2C+T%3BPiao%2C+Y%3BShaik%2C+N%3BKo%2C+MSH&rft.aulast=Sharova&rft.aufirst=LV&rft.date=2009-02-01&rft.volume=16&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=DNA+Research&rft.issn=13402838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - mRNA turnover; mRNA stability; Data processing; GADD45 protein; 3' Untranslated regions; Exons; CpG islands; DNA microarrays; Myc protein; Cytoskeleton; Databases; Stem cells; Embryo cells; Extracellular matrix; Transcription factors; Open reading frames; Metabolism ER - TY - JOUR T1 - A new method for improving functional-to-structural MRI alignment using local Pearson correlation AN - 20394441; 9066141 AB - Accurate registration of Functional Magnetic Resonance Imaging (FMRI) T2-weighted volumes to same-subject high-resolution T1-weighted structural volumes is important for Blood Oxygenation Level Dependent (BOLD) FMRI and crucial for applications such as cortical surface-based analyses and pre-surgical planning. Such registration is generally implemented by minimizing a cost functional, which measures the mismatch between two image volumes over the group of proper affine transformations. Widely used cost functionals, such as mutual information (MI) and correlation ratio (CR), appear to yield decent alignments when visually judged by matching outer brain contours. However, close inspection reveals that internal brain structures are often significantly misaligned. Poor registration is most evident in the ventricles and sulcal folds, where CSF is concentrated. This observation motivated our development of an improved modality-specific cost functional which uses a weighted local Pearson coefficient (LPC) to align T2- and T1-weighted images. In the absence of an alignment gold standard, we used three human observers blinded to registration method to provide an independent assessment of the quality of the registration for each cost functional. We found that LPC performed significantly better (p < 0.001) than generic cost functionals including MI and CR. Generic cost functionals were very often not minimal near the best alignment, thereby suggesting that optimization is not the cause of their failure. Lastly, we emphasize the importance of precise visual inspection of alignment quality and present an automated method for generating composite images that help capture errors of misalignment. JF - NeuroImage AU - Saad, Ziad S AU - Glen, Daniel R AU - Chen, Gang AU - Beauchamp, Michael S AU - Desai, Rutvik AU - Cox, Robert W AD - Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Dr. Room 1D80 Bethesda, MD 20892-1148 USA, rwcox@nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 839 EP - 848 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Transformation KW - Brain mapping KW - Cerebrospinal fluid KW - Functional magnetic resonance imaging KW - Automation KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20394441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=A+new+method+for+improving+functional-to-structural+MRI+alignment+using+local+Pearson+correlation&rft.au=Saad%2C+Ziad+S%3BGlen%2C+Daniel+R%3BChen%2C+Gang%3BBeauchamp%2C+Michael+S%3BDesai%2C+Rutvik%3BCox%2C+Robert+W&rft.aulast=Saad&rft.aufirst=Ziad&rft.date=2009-02-01&rft.volume=44&rft.issue=3&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.09.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Transformation; Brain mapping; Cerebrospinal fluid; Functional magnetic resonance imaging; Automation DO - http://dx.doi.org/10.1016/j.neuroimage.2008.09.037 ER - TY - JOUR T1 - In vivo labeling of adult neural progenitors for MRI with micron sized particles of iron oxide: Quantification of labeled cell phenotype AN - 20393815; 9066125 AB - The subventricular zone (SVZ) is a continual source of neural progenitors throughout adulthood. Many of the animal models designed to study the migration of these cells from the ventricle to places of interest like the olfactory bulb or an injury site require histology to localize precursor cells. Here, it is demonstrated that up to 30% of the neural progenitors that migrate along the rostral migratory stream (RMS) in an adult rodent can be labeled for MRI via intraventricular injection of micron sized particles of iron oxide (MPIOs). The precursors migrating from the SVZ along the RMS were found to populate the olfactory bulb with all three types of neural cells; neurons, oligodendrocytes, and astrocytes. In all cases 10-30% of these cells were labeled in the RMS en route to the olfactory bulb. Ara-C, an anti-mitotic agent, eliminated precursor cells at the SVZ, RMS, and olfactory bulb and also eliminated the MRI detection of the precursors. This indicates that the MRI signal detected is due to progenitor cells that leave the SVZ and is not due to non-specific diffusion of MPIOs. Using MRI to visualize neural progenitor cell behavior in individual animals during plasticity or disease models should be a useful tool, especially in combination with other information that MRI can supply. JF - NeuroImage AU - Sumner, James P AU - Shapiro, Erik M AU - Maric, Dragan AU - Conroy, Richard AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, NINDS, NIH, Building 10, Rm B1D728, 10 Center Drive, MSC 1065 Bethesda, MD 20892, USA, koretskya@ninds.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 671 EP - 678 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Ventricles (cerebral) KW - Astrocytes KW - Oligodendrocytes KW - iron oxides KW - Injuries KW - subventricular zone KW - Plasticity (neural) KW - Magnetic resonance imaging KW - Animal models KW - Olfactory bulb KW - Neurons KW - Diffusion KW - Cell migration KW - Neural stem cells KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20393815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Catalytic+mechanism+of+human+DNA+polymerase+lambda+with+Mg2%2B+and+Mn2%2B+from+ab+initio+quantum+mechanical%2Fmolecular+mechanical+studies.&rft.au=Cisneros%2C+G+Andr%C3%A9s%3BPerera%2C+Lalith%3BGarc%C3%ADa-D%C3%ADaz%2C+Miguel%3BBebenek%2C+Katarzyna%3BKunkel%2C+Thomas+A%3BPedersen%2C+Lee+G&rft.aulast=Cisneros&rft.aufirst=G&rft.date=2008-11-01&rft.volume=7&rft.issue=11&rft.spage=1824&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2008.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ventricles (cerebral); Injuries; iron oxides; Oligodendrocytes; Astrocytes; subventricular zone; Magnetic resonance imaging; Plasticity (neural); Animal models; Olfactory bulb; Neurons; Diffusion; Cell migration; Neural stem cells DO - http://dx.doi.org/10.1016/j.neuroimage.2008.07.050 ER - TY - JOUR T1 - Layer specific tracing of corticocortical and thalamocortical connectivity in the rodent using manganese enhanced MRI AN - 20393367; 9066149 AB - Information about layer specific connections in the brain comes mainly from classical neuronal tracers that rely on histology. Manganese Enhanced MRI (MEMRI) has mapped connectivity along a number of brain pathways in several animal models. It is not clear at what level of specificity neuronal connectivity measured using MEMRI tracing can resolve. The goal of this work was to determine if neural tracing using MEMRI could distinguish layer inputs of major pathways of the cortex. To accomplish this, tracing was performed between hemispheres of the somatosensory (S1) cortex and between the thalamus and S1 cortex. T1 mapping and T1 weighted pulse sequences detected layer specific tracing after local injection of MnCl2. Approximately 12 h following injections into S1 cortex, maximal T1 reductions were observed at 0.6 ± 0.07 and 1.1 ± 0.12 mm from the brain surface in the contralateral S1. These distances correspond to the positions of layer 3 and 5 consistent with the known callosal inputs along this pathway. Four to six hours following injection of MnCl2 into the thalamus there were maximal T1 reductions between 0.7 ± 0.08 and 0.8 ± 0.08 mm from the surface of the brain, which corresponds to layer 4. This is consistent with terminations of the known thalamocortical projections. In order to observe the first synapse projection, it was critical to perform MRI at the right time after injections to detect layer specificity with MEMRI. At later time points, tracing through the cortical network led to more uniform contrast throughout the cortex due to its complex neuronal connections. These results are consistent with well established neuronal pathways within the somatosensory cortex and demonstrate that layer specific somatosensory connections can be detected in vivo using MEMRI. JF - NeuroImage AU - Tucciarone, Jason AU - Chuang, Kai-Hsiang AU - Dodd, Steven J AU - Silva, Afonso AU - Pelled, Galit AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, B1D728, Bethesda, MD 20892-1065, USA, koretskya@ninds.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 923 EP - 931 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Tracers KW - Synapses KW - Cortex KW - Neural networks KW - Magnetic resonance imaging KW - Brain KW - Animal models KW - Manganese KW - Cortex (somatosensory) KW - Thalamus KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20393367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Layer+specific+tracing+of+corticocortical+and+thalamocortical+connectivity+in+the+rodent+using+manganese+enhanced+MRI&rft.au=Tucciarone%2C+Jason%3BChuang%2C+Kai-Hsiang%3BDodd%2C+Steven+J%3BSilva%2C+Afonso%3BPelled%2C+Galit%3BKoretsky%2C+Alan+P&rft.aulast=Tucciarone&rft.aufirst=Jason&rft.date=2009-02-01&rft.volume=44&rft.issue=3&rft.spage=923&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.07.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Tracers; Synapses; Cortex; Neural networks; Magnetic resonance imaging; Animal models; Brain; Manganese; Thalamus; Cortex (somatosensory) DO - http://dx.doi.org/10.1016/j.neuroimage.2008.07.036 ER - TY - JOUR T1 - Expansion of haematopoietic stem cells from normal donors and bone marrow failure patients by recombinant hoxb4 AN - 20392956; 9073587 AB - SummaryIn this study six versions of recombinant human hoxb4 proteins were produced and their effectiveness evaluated in expanding human haematopoietic stem and progenitor cells in vitro and in vivo. An N-terminal-tat and C-terminal histidine-tagged version of hoxb4 (T-hoxb4-H) showed the highest activity in expanding colony forming cells (CFCs) and long-term culture-initiating cells (LTC-ICs) when used at 50nmol/l concentration in cell culture. Human cord blood CD34+ cells cultured with 50nmol/l T-hoxb4-H showed a significant increase in severe-combined immunodeficient mouse-repopulating cells (SRCs). In a mouse model of immune-mediated bone marrow (BM) failure, T-hoxb4-H showed an additive effect with cyclosporine in alleviating pancytopenia. In addition, T-hoxb4-H expanded CFC and LTC-IC on BM samples from patients with refractory severe aplastic anaemia and myelodysplastic syndromes: after culturing with 50nmol/l T-hoxb4-H for 4d, BM cells from 10 of the 11 patients showed increases in CFC and LTC-IC, and the increase in LTC-IC was statistically significant in samples from four patients. Recombinant human hoxb4 could be a promising therapeutic agent for BM failure. JF - British Journal of Haematology AU - Tang, Yong AU - Chen, Jichun AU - Young, Neal S AD - Hematology Branch, National Heart, Lung, and Blood Institute, NIH Bethesda, MD, USA, youngn@nhlbi.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 603 EP - 612 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 144 IS - 4 SN - 0007-1048, 0007-1048 KW - Biotechnology and Bioengineering Abstracts KW - recombinant homobox b4 KW - haematopoietic stem and progenitor cells KW - CD34 KW - bone marrow failure KW - mouse models KW - HOXB4 protein KW - Statistical analysis KW - Animal models KW - Immunodeficiency KW - Bone marrow KW - Anemia KW - Pancytopenia KW - Cell culture KW - CD34 antigen KW - Cyclosporins KW - Cord blood KW - Myelodysplastic syndrome KW - Colonies KW - Stem cells KW - Src protein KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20392956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=Expansion+of+haematopoietic+stem+cells+from+normal+donors+and+bone+marrow+failure+patients+by+recombinant+hoxb4&rft.au=Tang%2C+Yong%3BChen%2C+Jichun%3BYoung%2C+Neal+S&rft.aulast=Tang&rft.aufirst=Yong&rft.date=2009-02-01&rft.volume=144&rft.issue=4&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Haematology&rft.issn=00071048&rft_id=info:doi/10.1111%2Fj.1365-2141.2008.07509.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - HOXB4 protein; Anemia; Bone marrow; Immunodeficiency; Animal models; Statistical analysis; CD34 antigen; Cell culture; Pancytopenia; Cyclosporins; Cord blood; Myelodysplastic syndrome; Stem cells; Colonies; Src protein DO - http://dx.doi.org/10.1111/j.1365-2141.2008.07509.x ER - TY - JOUR T1 - Susceptibility contrast in high field MRI of human brain as a function of tissue iron content AN - 20392081; 9066181 AB - Magnetic susceptibility provides an important contrast mechanism for MRI. Increasingly, susceptibility-based contrast is being exploited to investigate brain tissue microstructure and to detect abnormal levels of brain iron as these have been implicated in a variety of neuro-degenerative diseases. However, it remains unclear to what extent magnetic susceptibility-related contrast at high field relates to actual brain iron concentrations. In this study, we performed susceptibility weighted imaging as a function of field strength on healthy brains in vivo and post-mortem brain tissues at 1.5 T, 3 T and 7 T. Iron histology was performed on the tissue samples for comparison. The calculated susceptibility-related parameters R2 and signal frequency shift in four iron-rich regions (putamen, globus pallidus, caudate, and thalamus) showed an almost linear dependence (r >= 0.90 for R2; r >= 0.83 for phase, p < 0.01) on field strength, suggesting that potential ferritin saturation effects are not relevant to susceptibility-weighted contrast for field strengths up to 7 T. The R2 dependence on the putative (literature-based) iron concentration was 0.048 Hz/T/ppm. The histological data from brain samples confirmed the linear dependence of R2 on field strength and showed a slope against iron concentration of 0.0099 Hz/T/ppm dry-weight, which is equivalent to 0.05 Hz/T/ppm wet-weight and closely matched the calculated value in vivo. These results confirm the validity of using susceptibility-weighted contrast as an indicator of iron content in iron-rich brain regions. The absence of saturation effects opens the way to exploit the benefits of MRI at high field strengths for the detection of iron distributions with high sensitivity and resolution. JF - NeuroImage AU - Yao, Bing AU - Li, Tie-Qiang AU - van Gelderen, Peter AU - Shmueli, Karin AU - de Zwart, Jacco A AU - Duyn, Jeff H AD - Advanced MRI section, Laboratory of Functional Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bldg. 10, Room B1D728, Bethesda, MD 20892-1065, USA, yaob@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1259 EP - 1266 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Phase KW - Ferritin KW - Relaxation KW - Susceptibility KW - Brain KW - Iron KW - Neuroimaging KW - Data processing KW - Magnetic resonance imaging KW - Globus pallidus KW - Magnetic susceptibility KW - Thalamus KW - Putamen KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20392081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Susceptibility+contrast+in+high+field+MRI+of+human+brain+as+a+function+of+tissue+iron+content&rft.au=Yao%2C+Bing%3BLi%2C+Tie-Qiang%3Bvan+Gelderen%2C+Peter%3BShmueli%2C+Karin%3Bde+Zwart%2C+Jacco+A%3BDuyn%2C+Jeff+H&rft.aulast=Yao&rft.aufirst=Bing&rft.date=2009-02-01&rft.volume=44&rft.issue=4&rft.spage=1259&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.10.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Data processing; Globus pallidus; Magnetic resonance imaging; Brain; Magnetic susceptibility; Ferritin; Iron; Putamen; Thalamus DO - http://dx.doi.org/10.1016/j.neuroimage.2008.10.029 ER - TY - JOUR T1 - The impact of global signal regression on resting state correlations: Are anti-correlated networks introduced? AN - 20391893; 9066146 AB - Low-frequency fluctuations in fMRI signal have been used to map several consistent resting state networks in the brain. Using the posterior cingulate cortex as a seed region, functional connectivity analyses have found not only positive correlations in the default mode network but negative correlations in another resting state network related to attentional processes. The interpretation is that the human brain is intrinsically organized into dynamic, anti-correlated functional networks. Global variations of the BOLD signal are often considered nuisance effects and are commonly removed using a general linear model (GLM) technique. This global signal regression method has been shown to introduce negative activation measures in standard fMRI analyses. The topic of this paper is whether such a correction technique could be the cause of anti-correlated resting state networks in functional connectivity analyses. Here we show that, after global signal regression, correlation values to a seed voxel must sum to a negative value. Simulations also show that small phase differences between regions can lead to spurious negative correlation values. A combination breath holding and visual task demonstrates that the relative phase of global and local signals can affect connectivity measures and that, experimentally, global signal regression leads to bell-shaped correlation value distributions, centred on zero. Finally, analyses of negatively correlated networks in resting state data show that global signal regression is most likely the cause of anti-correlations. These results call into question the interpretation of negatively correlated regions in the brain when using global signal regression as an initial processing step. JF - NeuroImage AU - Murphy, Kevin AU - Birn, Rasmus M AU - Handwerker, Daniel A AU - Jones, Tyler B AU - Bandettini, Peter A AD - Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, USA, bandettini@nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 893 EP - 905 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Seeds KW - Data processing KW - Neural networks KW - Functional magnetic resonance imaging KW - Attention KW - Cortex (cingulate) KW - W 30910:Imaging KW - N3 11002:Computational & theoretical neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20391893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=The+impact+of+global+signal+regression+on+resting+state+correlations%3A+Are+anti-correlated+networks+introduced%3F&rft.au=Murphy%2C+Kevin%3BBirn%2C+Rasmus+M%3BHandwerker%2C+Daniel+A%3BJones%2C+Tyler+B%3BBandettini%2C+Peter+A&rft.aulast=Murphy&rft.aufirst=Kevin&rft.date=2009-02-01&rft.volume=44&rft.issue=3&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.09.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Seeds; Data processing; Neural networks; Functional magnetic resonance imaging; Attention; Cortex (cingulate) DO - http://dx.doi.org/10.1016/j.neuroimage.2008.09.036 ER - TY - JOUR T1 - Ceramides: Branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency AN - 20383884; 9065467 AB - The synthesis of a small number of ceramide analogues containing a combination of linear and highly branched alkyl chains on either the d-sphingosine or the N-acyl core of the molecule is reported. Regardless of location, the presence of the branched chain improves potency relative to the positive control, C2 ceramide; however, the most potent compound (4) has the branched side chain as part of the d-sphingosine core. The induction of apoptosis by 4 in terms of Annexin V binding and DiOC6 labeling was superior to that achieved with C2 ceramide. JF - Bioorganic and Medicinal Chemistry AU - Kang, Ji-Hye AU - Garg, Himanshu AU - Sigano, Dina M AU - Francella, Nicholas AU - Blumenthal, Robert AU - Marquez, Victor E AD - Laboratory of Medicinal Chemistry, National Cancer Institute, National Institutes of Health, Bldg 376/104, Frederick, MD 21702, United States, blumen@helix.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1498 EP - 1505 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 4 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Alkyl branched ceramides KW - d-Sphingosine KW - Apoptosis KW - SupT1 cells KW - Annexin V KW - DiOC6 KW - Ceramide KW - Sphingolipids KW - Siblings KW - Diacylglycerol KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20383884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Genetics&rft.atitle=Drug+resistance+and+genetic+mapping+in+Plasmodiumfalciparum&rft.au=Hayton%2C+Karen%3BSu%2C+Xin-zhuan&rft.aulast=Hayton&rft.aufirst=Karen&rft.date=2008-11-01&rft.volume=54&rft.issue=5&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Current+Genetics&rft.issn=01728083&rft_id=info:doi/10.1007%2Fs00294-008-0214-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; Ceramide; Sphingolipids; Siblings; Diacylglycerol; Annexin V DO - http://dx.doi.org/10.1016/j.bmc.2009.01.005 ER - TY - JOUR T1 - Cu-AMD3100-A novel imaging agent for targeting chemokine receptor CXCR4 AN - 20382875; 9065465 AB - CXCR4 is a chemokine receptor which has been shown to be exploited by various tumors for increased survival, invasion, and homing to target organs. We developed a one step radiosynthesis for labeling the CXCR4-specific antagonist AMD3100 with Cu-64 to produce 64Cu-AMD3100 with a specific activity of 11.28 Ci/ is a subset of mol (417 GBq/ is a subset of mol) at the end of radiosynthesis. Incorporation of Cu(II) ion into AMD3100 did not change its ability to inhibit cellular migration in response to the (only) CXCR4 ligand, SDF-1/CXCL12. 64Cu-AMD3100 binding affinity to CXCR4 was found to be 62.7 is a subset of M. Biodistribution of 64Cu-AMD3100 showed accumulation in CXCR4-expressing organs and tissues, a renal clearance pathway, and an anomalous specific accumulation in the liver. We conclude that 64Cu-AMD3100 exhibits promise as a potential PET imaging agent for visualization of CXCR4-positive tumors and metastases and might be used to guide and monitor anti-CXCR4 tumor therapy. JF - Bioorganic and Medicinal Chemistry AU - Jacobson, Orit AU - Weiss, Ido D AU - Szajek, Lawrence AU - Farber, Joshua M AU - Kiesewetter, Dale O AD - Positron Emission Tomography Radiochemistry Group, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD 20892, USA, dk7k@nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 1486 EP - 1493 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 4 SN - 0968-0896, 0968-0896 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - AMD3100 KW - CXCR4 KW - PET KW - Copper-64 KW - Metastases KW - SDF-1 protein KW - CXCR4 protein KW - Homing behavior KW - Kidney KW - Liver KW - Chemokine receptors KW - Survival KW - Tumors KW - Cell migration KW - CXCL12 protein KW - W 30910:Imaging KW - F 06955:Immunomodulation & Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20382875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Cu-AMD3100-A+novel+imaging+agent+for+targeting+chemokine+receptor+CXCR4&rft.au=Jacobson%2C+Orit%3BWeiss%2C+Ido+D%3BSzajek%2C+Lawrence%3BFarber%2C+Joshua+M%3BKiesewetter%2C+Dale+O&rft.aulast=Jacobson&rft.aufirst=Orit&rft.date=2009-02-01&rft.volume=17&rft.issue=4&rft.spage=1486&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2009.01.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Metastases; SDF-1 protein; CXCR4 protein; Homing behavior; Liver; Kidney; Survival; Chemokine receptors; Cell migration; Tumors; CXCL12 protein DO - http://dx.doi.org/10.1016/j.bmc.2009.01.014 ER - TY - JOUR T1 - Recombineering: a homologous recombination-based method of genetic engineering AN - 20349582; 9024169 AB - Recombineering is an efficient method of in vivo genetic engineering applicable to chromosomal as well as episomal replicons in Escherichia coli. This method circumvents the need for most standard in vitro cloning techniques. Recombineering allows construction of DNA molecules with precise junctions without constraints being imposed by restriction enzyme site location. Bacteriophage homologous recombination proteins catalyze these recombineering reactions using double- and single-stranded linear DNA substrates, so-called targeting constructs, introduced by electroporation. Gene knockouts, deletions and point mutations are readily made, gene tags can be inserted and regions of bacterial artificial chromosomes or the E. coli genome can be subcloned by gene retrieval using recombineering. Most of these constructs can be made within about 1 week's time. JF - Nature Protocols AU - Sharan, Shyam K AU - Thomason, Lynn C AU - Kuznetsov, Sergey G AU - Court, Donald L Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 206 EP - 223 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 4 IS - 2 SN - 1754-2189, 1754-2189 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genetic modification KW - Genomes KW - Phages KW - Electroporation KW - Point mutation KW - Enzymes KW - Site location KW - Bacterial artificial chromosomes KW - Gene deletion KW - Genetic engineering KW - Chromosome deletion KW - Escherichia coli KW - DNA KW - homologous recombination KW - J 02410:Animal Diseases KW - V 22410:Animal Diseases KW - W 30900:Methods KW - G 07760:Viruses & Phages KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20349582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Recombineering%3A+a+homologous+recombination-based+method+of+genetic+engineering&rft.au=Sharan%2C+Shyam+K%3BThomason%2C+Lynn+C%3BKuznetsov%2C+Sergey+G%3BCourt%2C+Donald+L&rft.aulast=Sharan&rft.aufirst=Shyam&rft.date=2009-02-01&rft.volume=4&rft.issue=2&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.227 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phages; Bacterial artificial chromosomes; Genomes; Gene deletion; Electroporation; Genetic engineering; Point mutation; Chromosome deletion; DNA; Enzymes; Site location; homologous recombination; Escherichia coli DO - http://dx.doi.org/10.1038/nprot.2008.227 ER - TY - JOUR T1 - Monte Carlo electron-trajectory simulations in bright-field and dark-field STEM: Implications for tomography of thick biological sections AN - 20346910; 9022044 AB - A Monte Carlo electron-trajectory calculation has been implemented to assess the optimal detector configuration for scanning transmission electron microscopy (STEM) tomography of thick biological sections. By modeling specimens containing 2 and 3at% osmium in a carbon matrix, it was found that for 1- mu m-thick samples the bright-field (BF) and annular dark-field (ADF) signals give similar contrast and signal-to-noise ratio provided the ADF inner angle and BF outer angle are chosen optimally. Spatial resolution in STEM imaging of thick sections is compromised by multiple elastic scattering which results in a spread of scattering angles and thus a spread in lateral distances of the electrons leaving the bottom surface. However, the simulations reveal that a large fraction of these multiply scattered electrons are excluded from the BF detector, which results in higher spatial resolution in BF than in high-angle ADF images for objects situated towards the bottom of the sample. The calculations imply that STEM electron tomography of thick sections should be performed using a BF rather than an ADF detector. This advantage was verified by recording simultaneous BF and high-angle ADF STEM tomographic tilt series from a stained 600-nm-thick section of C. elegans. It was found that loss of spatial resolution occurred markedly at the bottom surface of the specimen in the ADF STEM but significantly less in the BF STEM tomographic reconstruction. Our results indicate that it might be feasible to use BF STEM tomography to determine the 3D structure of whole eukaryotic microorganisms prepared by freeze-substitution, embedding, and sectioning. JF - Ultramicroscopy AU - Sousa, A A AU - Hohmann-Marriott, M F AU - Zhang, G AU - Leapman, R D AD - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bldg. 13, Rm. 3N17, 13 South Drive, Bethesda, MD 20892-5766, USA, leapmanr@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 213 EP - 221 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 109 IS - 3 SN - 0304-3991, 0304-3991 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Carbon KW - Transmission electron microscopy KW - Sectioning KW - Microorganisms KW - Tomography KW - spatial discrimination KW - osmium KW - imaging KW - Embedding KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultramicroscopy&rft.atitle=Monte+Carlo+electron-trajectory+simulations+in+bright-field+and+dark-field+STEM%3A+Implications+for+tomography+of+thick+biological+sections&rft.au=Sousa%2C+A+A%3BHohmann-Marriott%2C+M+F%3BZhang%2C+G%3BLeapman%2C+R+D&rft.aulast=Sousa&rft.aufirst=A&rft.date=2009-02-01&rft.volume=109&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Ultramicroscopy&rft.issn=03043991&rft_id=info:doi/10.1016%2Fj.ultramic.2008.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Carbon; Transmission electron microscopy; Sectioning; Microorganisms; Tomography; osmium; spatial discrimination; Embedding; imaging DO - http://dx.doi.org/10.1016/j.ultramic.2008.10.005 ER - TY - JOUR T1 - Use of human tissue explants to study human infectious agents AN - 20346788; 9024175 AB - The study of human cell-cell and cell-pathogen interactions that occur in the context of complex tissue cytoarchitecture is critical for deciphering the mechanisms of many normal and pathogenic processes. This protocol describes methods for culturing and infecting explants of human tissues to study the pathogenesis of human infectious agents and their local interactions. The protocol relies on the use of fresh human tissues dissected into small blocks or biopsies that are cultured at the liquid-air interface on collagen rafts. These tissue blocks retain their cytoarchitecture and support productive infection of various pathogens without exogenous stimulation. Experimental details for setting up cultures of human tonsils, lymph nodes and cervicovaginal and rectosigmoid tissues, including protocols for their infection with HIV-1 and other pathogens, are described here. Using this protocol, culture and infections can be set up in 3-6 h and be maintained for 2-3 weeks, depending on the tissue used. JF - Nature Protocols AU - Grivel, Jean-Charles AU - Margolis, Leonid Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 256 EP - 269 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 4 IS - 2 SN - 1754-2189, 1754-2189 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Cell and tissue culture KW - Isolation purification and separation KW - Tonsil KW - Human immunodeficiency virus 1 KW - Cell culture KW - Biopsy KW - Pathogens KW - Infection KW - Explants KW - Lymph nodes KW - Collagen KW - A 01340:Antibiotics & Antimicrobials KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Use+of+human+tissue+explants+to+study+human+infectious+agents&rft.au=Grivel%2C+Jean-Charles%3BMargolis%2C+Leonid&rft.aulast=Grivel&rft.aufirst=Jean-Charles&rft.date=2009-02-01&rft.volume=4&rft.issue=2&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Tonsil; Biopsy; Cell culture; Pathogens; Infection; Explants; Lymph nodes; Collagen; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1038/nprot.2008.245 ER - TY - JOUR T1 - Physical Activity and Esophageal and Gastric Carcinoma in a Large Prospective Study AN - 20337105; 9010987 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Leitzmann, Michael F AU - Koebnick, Corinna AU - Freedman, Neal D AU - Park, Yikyung AU - Ballard-Barbash, Rachel AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Abnet, Christian C AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 112 EP - 119 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 36 IS - 2 SN - 0749-3797, 0749-3797 KW - Physical Education Index KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20337105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+abuse+reviews&rft.atitle=Hypothesis-driven+medication+discovery+for+the+treatment+of+psychostimulant+addiction.&rft.au=Xi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2008-11-01&rft.volume=1&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Current+drug+abuse+reviews&rft.issn=1874-4745&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Exercise DO - http://dx.doi.org/10.1016/j.amepre.2008.09.033 ER - TY - JOUR T1 - Polychlorinated biphenyl serum concentrations, lifestyle and time-to-pregnancy AN - 20325116; 9014509 AB - BACKGROUND Consumption of fish contaminated with polychlorinated biphenyls (PCBs) and prenatal PCB serum concentrations have been associated with a longer time-to-pregnancy (TTP). However, the relationship between preconception serum PCBs concentrations and TTP has not been previously studied.METHODS Eighty-three women (contributing 442 menstrual cycles) planning pregnancies completed daily diaries regarding menstruation, intercourse, home pregnancy test results, and reported use of alcohol and cigarettes. TTP denoted the number of observed menstrual cycles required for pregnancy. Preconception blood specimens underwent toxicologic analysis for 76 PCB congeners via gas chromatography with electron capture; serum lipids were quantified with enzymatic methods. A priori, PCB congeners were summed into a total and three groupings-estrogenic, anti-estrogenic and other-and entered into discrete analogs of Cox models with time-varying covariates to estimate fecundability odds ratios (FOR) and corresponding 95% confidence intervals (CIs).RESULTS Estrogenic and anti-estrogenic PCB concentrations (ng/g serum) conferred reduced FORs in fully adjusted models (0.32; 95% CI 0.03, 3.90 and 0.01: 95% CI [Lt] 0.00, 1.99, respectively). Reduced FORs (0.96) were observed for alcohol consumption standardized to a 28-day menstrual cycle in the same adjusted model (FOR = 0.96; 95% CI 0.93, 1.00).CONCLUSIONS These data suggest that environmental exposures including those amenable to change, such as alcohol consumption, may impact female fecundity. The findings are sensitive to model specification and PCB groupings, underscoring the need to further assess the impact of chemical mixtures on sensitive reproductive outcomes, such as TTP, especially in the context of lifestyle factors which are amenable to change, thereby improving reproductive health. JF - Human Reproduction AU - Buck Louis, GM AU - Dmochowski, J AU - Lynch, C AU - Kostyniak, P AU - McGuinness, B M AU - Vena, JE AD - 1 Epidemiology Branch , Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development , 6100 Executive Blvd, Rm. 7B03, Rockville, MD 20852, louisg@mail.nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 451 EP - 458 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 24 IS - 2 SN - 0268-1161, 0268-1161 KW - Sustainability Science Abstracts; Risk Abstracts KW - time-to-pregnancy KW - polychlorinated biphenyls KW - fecundity KW - lifestyle KW - environment KW - Alcohol KW - Estrogens KW - Cigarettes KW - Lipids KW - Pregnancy KW - Fecundity KW - Bioaccumulation KW - Gas chromatography KW - Reproduction KW - Standards KW - PCB compounds KW - estrogens KW - M3 1010:Issues in Sustainable Development KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20325116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Polychlorinated+biphenyl+serum+concentrations%2C+lifestyle+and+time-to-pregnancy&rft.au=Buck+Louis%2C+GM%3BDmochowski%2C+J%3BLynch%2C+C%3BKostyniak%2C+P%3BMcGuinness%2C+B+M%3BVena%2C+JE&rft.aulast=Buck+Louis&rft.aufirst=GM&rft.date=2009-02-01&rft.volume=24&rft.issue=2&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/10.1093%2Fhumrep%2Fden373 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Alcohol; Estrogens; Cigarettes; Lipids; Pregnancy; fecundity; Bioaccumulation; Fecundity; Gas chromatography; Standards; Reproduction; PCB compounds; estrogens DO - http://dx.doi.org/10.1093/humrep/den373 ER - TY - JOUR T1 - Production, purification, and characterization of human a1 proteinase inhibitor from Aspergillus niger AN - 20171918; 10248100 AB - Human alpha one proteinase inhibitor (1-PI) was cloned and expressed in Aspergillus niger, filamentious fungus that can grow in defined media and can perform glycosylation. Submerged culture conditions were established using starch as carbon source, 30% dissolved oxygen concentration, pH 7.0 and 28°C. Eight milligrams per liter of active 1-PI were secreted to the growth media in about 40 h. Controlling the protein proteolysis was found to be an important factor in the production. The effects of various carbon sources, pH and temperature on the production and stability of the protein were tested and the product was purified and characterized. Two molecular weights variants of the recombinant 1-PI were produced by the fungus; the difference is attributed to the glycosylated part of the molecule. The two glycoproteins were treated with PNGAse F and the released glycans were analyzed by HPAEC, MALDI/TOF-MS, NSI-MSn, and GC-MS. The MALDI and NSI- full MS spectra of permethylated N-glycans revealed that the N-glycans of both variants contain a series of high-mannose type glycans with 5-20 hexose units. Monosaccharide analysis showed that these were composed of N-acetylglucos-amine, mannose, and galactose. Linkage analysis revealed that the galactosyl component was in the furanoic conformation, which was attaching in a terminal non-reducing position. The Galactofuranose-containing high-mannnose type N-glycans are typical structures, which recently have been found as part of several glycoproteins produced by Aspergillus niger. Biotechnol. Bioeng. 2009; 102: 828-844. JF - Biotechnology and Bioengineering AU - Chill, Liat AU - Trinh, Loc AU - Azadi, Parastoo AU - Ishihara, Mayumi AU - Sonon, Roberto AU - Karnaukhova, Elena AU - Ophir, Yakir AU - Golding, Basil AU - Shiloach, Joseph AD - Biotechnology Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 14A Room 170, 9000 Rockville Pike, Bethesda, Maryland 20892; , yossi@nih.gov Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 828 EP - 844 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 102 IS - 3 SN - 0006-3592, 0006-3592 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Proteolysis KW - Galactose KW - Mannose KW - Proteinase inhibitors KW - protein purification KW - Carbon sources KW - Glycosylation KW - monosaccharides KW - Polysaccharides KW - Starch KW - Dissolved oxygen KW - Linkage analysis KW - Hexose KW - N-glycans KW - Molecular weight KW - Glycoproteins KW - pH effects KW - Aspergillus niger KW - Media (culture) KW - W 30935:Food Biotechnology KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20171918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Production%2C+purification%2C+and+characterization+of+human+a1+proteinase+inhibitor+from+Aspergillus+niger&rft.au=Chill%2C+Liat%3BTrinh%2C+Loc%3BAzadi%2C+Parastoo%3BIshihara%2C+Mayumi%3BSonon%2C+Roberto%3BKarnaukhova%2C+Elena%3BOphir%2C+Yakir%3BGolding%2C+Basil%3BShiloach%2C+Joseph&rft.aulast=Chill&rft.aufirst=Liat&rft.date=2009-02-01&rft.volume=102&rft.issue=3&rft.spage=828&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/10.1002%2Fbit.22099 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Galactose; Proteolysis; Temperature effects; Mannose; Proteinase inhibitors; monosaccharides; Glycosylation; Carbon sources; protein purification; Starch; Polysaccharides; Dissolved oxygen; Linkage analysis; Hexose; Molecular weight; N-glycans; Glycoproteins; pH effects; Media (culture); Aspergillus niger DO - http://dx.doi.org/10.1002/bit.22099 ER - TY - JOUR T1 - Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees AN - 195066803; 19137238 AB - We sought to determine whether premenstrual mood symptoms exhibit familial aggregation in bipolar disorder or major depression pedigrees. Two thousand eight hundred seventy-six women were interviewed with the Diagnostic Interview for Genetic Studies as part of either the NIMH Genetics Initiative Bipolar Disorder Collaborative study or the Genetics of Early Onset Major Depression (GenRED) study and asked whether they had experienced severe mood symptoms premenstrually. In families with two or more female siblings with bipolar disorder (BP) or major depressive disorder (MDD), we examined the odds of having premenstrual mood symptoms given one or more siblings with these symptoms. For the GenRED MDD sample we also assessed the impact of personality as measured by the NEO-FFI. Premenstrual mood symptoms did not exhibit familial aggregation in families with BP or MDD. We unexpectedly found an association between high NEO openness scores and premenstrual mood symptoms, but neither this factor, nor NEO neuroticism influenced evidence for familial aggregation of symptoms. Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use. [PUBLICATION ABSTRACT] JF - Archives of Women's Mental Health AU - Payne, Jennifer L AU - Klein, Sarah R AU - Zamoiski, Rachel B AU - Zandi, Peter P AU - Bienvenu, Oscar J AU - Mackinnon, Dean F AU - Mondimore, Francis M AU - Schweizer, Barbara AU - Swartz, Karen L AU - Crowe, Raymond P AU - Scheftner, William A AU - Weissman, Myrna M AU - Levinson, Douglas F AU - Depaulo, J Raymond AU - Potash, James B Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 27 EP - 34 CY - New York PB - Springer Science & Business Media VL - 12 IS - 1 SN - 14341816 KW - Psychology KW - Premenstrual syndrome--PMS KW - Mental depression KW - Bipolar disorder KW - Genetics KW - United States KW - Pedigree KW - Odds Ratio KW - Premenstrual Syndrome -- psychology KW - Bipolar Disorder KW - Humans KW - Depressive Disorder, Major -- psychology KW - Adult KW - Interviews as Topic KW - Depressive Disorder, Major -- genetics KW - Female KW - Personality KW - Premenstrual Syndrome -- genetics KW - Mood Disorders -- physiopathology KW - Mood Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/195066803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Women%27s+Mental+Health&rft.atitle=Premenstrual+mood+symptoms%3A+study+of+familiality+and+personality+correlates+in+mood+disorder+pedigrees&rft.au=Payne%2C+Jennifer+L%3BKlein%2C+Sarah+R%3BZamoiski%2C+Rachel+B%3BZandi%2C+Peter+P%3BBienvenu%2C+Oscar+J%3BMackinnon%2C+Dean+F%3BMondimore%2C+Francis+M%3BSchweizer%2C+Barbara%3BSwartz%2C+Karen+L%3BCrowe%2C+Raymond+P%3BScheftner%2C+William+A%3BWeissman%2C+Myrna+M%3BLevinson%2C+Douglas+F%3BDepaulo%2C+J+Raymond%3BPotash%2C+James+B&rft.aulast=Payne&rft.aufirst=Jennifer&rft.date=2009-02-01&rft.volume=12&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Archives+of+Women%27s+Mental+Health&rft.issn=14341816&rft_id=info:doi/10.1007%2Fs00737-008-0043-4 LA - English DB - ProQuest Central N1 - Copyright - Springer-Verlag 2009 N1 - Last updated - 2014-09-10 DO - http://dx.doi.org/10.1007/s00737-008-0043-4 ER - TY - JOUR T1 - Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury AN - 1328997050 AB - To determine if levels of soluble intercellular adhesion molecule-1 (sICAM-1), a marker of alveolar epithelial and endothelial injury, differ in patients with hydrostatic pulmonary edema and acute lung injury (ALI) and are associated with clinical outcomes in patients with ALI. Measurement of sICAM-1 levels in (1) plasma and edema fluid from 67 patients with either hydrostatic pulmonary edema or ALI enrolled in an observational, prospective single center study, and (2) in plasma from 778 patients with ALI enrolled in a large multi-center randomized controlled trial of ventilator strategy. In the single-center study, levels of sICAM-1 were significantly higher in both edema fluid and plasma (median 938 and 545Â ng/ml, respectively) from ALI patients compared to hydrostatic edema patients (median 384 and 177Â ng/ml, PÂ <Â 0.03 for both comparisons). In the multi-center study, higher plasma sICAM-1 levels were associated with poor clinical outcomes in both unadjusted and multivariable models. Subjects with ALI whose plasma sICAM-1 levels increased over the first 3Â days of the study had a higher risk of death, after adjusting for other important predictors of outcome (odds ratio 1.48; 95% CI 1.03â[euro]"2.12, PÂ =Â 0.03). Both plasma and edema fluid levels of sICAM-1 are higher in patients with ALI than in patients with hydrostatic pulmonary edema. Higher plasma sICAM-1 levels and increasing sICAM-1 levels over time are associated with poor clinical outcomes in ALI. Measurement of sICAM-1 levels may be useful for identifying patients at highest risk of poor outcomes from ALI.[PUBLICATION ABSTRACT] JF - Intensive Care Medicine AU - Calfee, Carolyn S AU - Eisner, Mark D AU - Parsons, Polly E AU - Thompson, B Taylor AU - Conner, Edward R, Jr AU - Matthay, Michael A AU - Ware, Lorraine B Y1 - 2009/02// PY - 2009 DA - Feb 2009 SP - 248 EP - 257 CY - Heidelberg PB - Springer Science & Business Media VL - 35 IS - 2 SN - 03424642 KW - Medical Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1328997050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Soluble+intercellular+adhesion+molecule-1+and+clinical+outcomes+in+patients+with+acute+lung+injury%3A+%5B1%5D&rft.au=Calfee%2C+Carolyn+S%3BEisner%2C+Mark+D%3BParsons%2C+Polly+E%3BThompson%2C+B+Taylor%3BConner%2C+Edward+R%2C+Jr%3BMatthay%2C+Michael+A%3BWare%2C+Lorraine+B&rft.aulast=Calfee&rft.aufirst=Carolyn&rft.date=2009-02-01&rft.volume=374&rft.issue=2&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=1089-8638&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Springer-Verlag 2009 N1 - Last updated - 2014-08-02 DO - http://dx.doi.org/10.1007/s00134-008-1235-0 ER - TY - JOUR T1 - ABCG2: a perspective. AN - 66891645; 19135109 AB - ABCG2, or breast cancer resistance protein (BCRP), is an ABC transporter that has been the subject of intense study since its discovery a decade ago. With high normal tissue expression in the brain endothelium, gastrointestinal tract, and placenta, ABCG2 is believed to be important in the protection from xenobiotics, regulating oral bioavailability, forming part of the blood-brain barrier, the blood-testis barrier, and the maternal-fetal barrier. Notably, ABCG2 is often expressed in stem cell populations, where it likely plays a role in xenobiotic protection. However, clues to its epigenetic regulation in various cell populations are only beginning to emerge. While ABCG2 overexpression has been demonstrated in cancer cells after in vitro drug treatment, endogenous ABCG2 expression in certain cancers is likely a reflection of the differentiated phenotype of the cell of origin and likely contributes to intrinsic drug resistance. Notably, research into the transporter's role in cancer drug resistance and its development as a therapeutic target in cancer has lagged. Substrates and inhibitors of the transporter have been described, among them chemotherapy drugs, tyrosine kinase inhibitors, antivirals, HMG-CoA reductase inhibitors, carcinogens, and flavonoids. This broad range of substrates complements the efficiency of ABCG2 as a transporter in laboratory studies and suggests that, while there are redundant mechanisms of xenobiotic protection, the protein is important in normal physiology. Indeed, emerging studies in pharmacology and toxicology assessing polymorphic variants in man, in combination with murine knockout models have confirmed its dynamic role. Work in pharmacology may eventually lead us to a greater understanding of the physiologic role of ABCG2. JF - Advanced drug delivery reviews AU - Robey, Robert W AU - To, Kenneth K K AU - Polgar, Orsolya AU - Dohse, Marius AU - Fetsch, Patricia AU - Dean, Michael AU - Bates, Susan E AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/01/31/ PY - 2009 DA - 2009 Jan 31 SP - 3 EP - 13 VL - 61 IS - 1 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Antineoplastic Agents KW - Neoplasm Proteins KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- pharmacokinetics KW - Humans KW - Biological Transport KW - Organ Specificity KW - Tissue Distribution KW - Substrate Specificity KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Neoplasms -- metabolism KW - Neoplasm Proteins -- physiology KW - ATP-Binding Cassette Transporters -- physiology KW - ATP-Binding Cassette Transporters -- metabolism KW - Neoplasm Proteins -- genetics KW - ATP-Binding Cassette Transporters -- genetics KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66891645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+drug+delivery+reviews&rft.atitle=ABCG2%3A+a+perspective.&rft.au=Robey%2C+Robert+W%3BTo%2C+Kenneth+K+K%3BPolgar%2C+Orsolya%3BDohse%2C+Marius%3BFetsch%2C+Patricia%3BDean%2C+Michael%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2009-01-31&rft.volume=61&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Advanced+drug+delivery+reviews&rft.issn=1872-8294&rft_id=info:doi/10.1016%2Fj.addr.2008.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-17 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 2006 Dec;70(6):2127-33 [16959944] Blood. 2006 Dec 1;108(12):3881-9 [16917002] J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42 [17148776] Drug Metab Dispos. 2007 Feb;35(2):209-14 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J Dairy Sci. 2006 Dec;89(12):4921-3 [17106124] Genes Chromosomes Cancer. 2000 Jan;27(1):110-6 [10564593] Cancer Res. 2000 Jan 1;60(1):47-50 [10646850] Cancer Lett. 1999 Nov 15;146(2):117-26 [10656616] J Mol Biol. 2000 Feb 25;296(3):911-9 [10677291] Blood. 2000 Jul 1;96(1):365-8 [10891476] J Natl Cancer Inst. 2000 Oct 18;92(20):1651-6 [11036110] Mamm Genome. 2001 Jan;12(1):86-8 [11178751] Cancer Res. 2001 Apr 15;61(8):3458-64 [11309308] Clin Pharmacokinet. 2001;40(3):159-68 [11327196] Genome Res. 2001 Jul;11(7):1156-66 [11435397] Biochem Biophys Res Commun. 2001 Jul 6;285(1):111-7 [11437380] Nat Med. 2001 Sep;7(9):1028-34 [11533706] Toxicology. 2001 Oct 5;167(1):3-23 [11557126] Cancer Res. 2001 Sep 15;61(18):6635-9 [11559526] Biochim Biophys Acta. 2001 Sep 21;1520(3):234-41 [11566359] Blood. 2002 Jan 15;99(2):507-12 [11781231] Int J Cancer. 2002 Feb 10;97(5):626-30 [11807788] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] J Clin Invest. 2002 Sep;110(5):659-69 [12208867] J Pathol. 2002 Oct;198(2):213-9 [12237881] Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12339-44 [12218177] Neuroreport. 2002 Nov 15;13(16):2059-63 [12438926] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15649-54 [12429862] Curr Opin Investig Drugs. 2002 Nov;3(11):1652-9 [12476969] Mol Cancer Ther. 2002 Jun;1(8):611-6 [12479221] Blood. 2003 Mar 15;101(6):2368-73 [12609962] Int J Oncol. 2003 May;22(5):1117-21 [12684679] Brain Res. 2003 May 9;971(2):221-31 [12706238] Cancer Sci. 2003 Jun;94(6):557-63 [12824882] J Biol Chem. 2003 Oct 3;278(40):39068-75 [12851395] Cancer Res. 2003 Oct 1;63(19):6447-52 [14559835] Int J Cancer. 2003 Dec 10;107(5):757-63 [14566825] FASEB J. 2003 Nov;17(14):2085-7 [12958161] Br J Cancer. 2003 Nov 17;89(10):1971-8 [14612912] Blood. 2003 Dec 15;102(13):4499-503 [12881321] Int J Cancer. 2004 Mar 20;109(2):238-46 [14750175] Cancer Res. 2004 Feb 15;64(4):1242-6 [14973080] Cancer Res. 2004 Feb 15;64(4):1247-51 [14973083] Clin Cancer Res. 2004 Mar 1;10(5):1826-34 [15014037] Cancer Res. 2004 Apr 1;64(7):2333-7 [15059881] Eur J Haematol. 2004 May;72(5):314-21 [15059065] Cancer Res. 2004 May 1;64(9):3296-301 [15126373] Mol Pharmacol. 2004 Jun;65(6):1485-95 [15155841] J Biol Chem. 2004 Jun 4;279(23):24218-25 [15044468] Annu Rev Biochem. 2004;73:241-68 [15189142] Clin Pharmacol Ther. 2004 Jul;76(1):38-44 [15229462] J Neurochem. 2004 Aug;90(3):526-36 [15255930] Biochemistry. 2004 Jul 27;43(29):9448-56 [15260487] Lab Invest. 2004 Aug;84(8):1024-36 [15146167] Drug Metab Dispos. 2004 Sep;32(9):898-901 [15319327] Eur J Cancer. 2004 Sep;40(14):2064-70 [15341980] Cancer Res. 1970 Apr;30(4):1174-84 [5533992] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addr.2008.11.003 ER - TY - CPAPER T1 - The Need to Collect Individual Exposure-Related Data Following Radiation Accidents and Events T2 - 42nd Annual Midyear Meeting of the Health Physics Society AN - 41753927; 5025142 JF - 42nd Annual Midyear Meeting of the Health Physics Society AU - Simon, S AU - Bouville, A Y1 - 2009/01/31/ PY - 2009 DA - 2009 Jan 31 KW - Accidents KW - Radiation KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41753927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+Annual+Midyear+Meeting+of+the+Health+Physics+Society&rft.atitle=The+Need+to+Collect+Individual+Exposure-Related+Data+Following+Radiation+Accidents+and+Events&rft.au=Simon%2C+S%3BBouville%2C+A&rft.aulast=Simon&rft.aufirst=S&rft.date=2009-01-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+Annual+Midyear+Meeting+of+the+Health+Physics+Society&rft.issn=&rft_id=info:doi/ L2 - http://hps.org/documents/2009_midyear_program_preliminary.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Proteasomal Protein Degradation in Mycobacteria Is Dependent upon a Prokaryotic Ubiquitin-like Protein AN - 21081515; 11080011 AB - The striking identification of an apparent proteasome core in Mycobacteria and allied actinomycetes suggested that additional elements of this otherwise strictly eukaryotic system for regulated protein degradation might be conserved. The genes encoding this prokaryotic proteasome are clustered in an operon with a short open reading frame that encodes a small protein of 64 amino acids resembling ubiquitin with a carboxyl-terminal di-glycine-glutamine motif (herein called Pup for prokaryotic ubiquitin-like protein). Expression of a polyhistidine-tagged Pup followed by pulldown revealed that a broad spectrum of proteins were post-translationally modified by Pup. Two-dimensional gel electrophoresis allowed us to conclusively identify two targets of this modification as myoinositol-1-phosphate synthase and superoxide dismutase. Deletion of the penultimate di-glycine motif or the terminal glutamine completely abrogated modification of cellular proteins with Pup. Further mass spectral analysis demonstrated that Pup was attached to a lysine residue on its target protein via the carboxyl-terminal glutamine with deamidation of this residue. Finally, we showed that cell lysates of wild type (but not a proteasome mutant) efficiently degraded Pup-modified proteins. These data therefore establish that, despite differences in both sequence and target linkage, Pup plays an analogous role to ubiquitin in targeting proteins to the proteasome for degradation. JF - Journal of Biological Chemistry AU - Burns, Kristin E AU - Liu, Wei-Ting AU - Boshoff, Helena IM AU - Dorrestein, Pieter C AU - Barry, Clifton E, III AD - Tuberculosis Research Section, NIAID, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2009/01/30/ PY - 2009 DA - 2009 Jan 30 SP - 3069 EP - 3075 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 284 IS - 5 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Glutamine KW - Amino acids KW - Data processing KW - proteasomes KW - Lysine KW - Gel electrophoresis KW - Post-translation KW - Superoxide dismutase KW - Operons KW - Actinomycetes KW - Open reading frames KW - Ubiquitin KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21081515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Correlations+of+maternal+buprenorphine+dose%2C+buprenorphine%2C+and+metabolite+concentrations+in+meconium+with+neonatal+outcomes.&rft.au=Kacinko%2C+S+L%3BJones%2C+H+E%3BJohnson%2C+R+E%3BChoo%2C+R+E%3BHuestis%2C+M+A&rft.aulast=Kacinko&rft.aufirst=S&rft.date=2008-11-01&rft.volume=84&rft.issue=5&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.156 L2 - http://www.jbc.org/cgi/reprint/284/5/3069.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Glutamine; Data processing; Amino acids; Post-translation; Superoxide dismutase; proteasomes; Lysine; Operons; Open reading frames; Gel electrophoresis; Actinomycetes; Ubiquitin DO - http://dx.doi.org/10.1074/jbc.M808032200 ER - TY - JOUR T1 - PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer. AN - 66865037; 18997818 AB - Inactivation and silencing of PTEN have been observed in multiple cancers, including follicular thyroid carcinoma. PTEN (phosphatase and tensin homologue deleted from chromosome 10) functions as a tumour suppressor by opposing the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signalling pathway. Despite correlative data, how deregulated PTEN signalling leads to thyroid carcinogenesis is not known. Mice harbouring a dominant-negative mutant thyroid hormone receptor beta (TRbeta(PV/PV) mice) spontaneously develop follicular thyroid carcinoma and distant metastases similar to human cancer. To elucidate the role of PTEN in thyroid carcinogenesis, we generated TRbeta(PV/PV) mice haploinsufficient for Pten (TRbeta(PV/PV)Pten(+/-) mouse). PTEN deficiency accelerated the progression of thyroid tumour and increased the occurrence of metastasis spread to the lung in TRbeta(PV/PV)Pten(+/-) mice, thereby significantly reducing their survival as compared with TRbeta(PV/PV)Pten(+/+) mice. AKT activation was further increased by two-fold in TRbeta(PV/PV)Pten(+/-) mice thyroids, leading to increased activity of the downstream mammalian target of rapamycin (mTOR)-p70S6K signalling and decreased activity of the forkhead family member FOXO3a. Consistently, cyclin D1 expression was increased. Apoptosis was decreased as indicated by increased expression of nuclear factor-kappaB (NF-kappaB) and decreased caspase-3 activity in the thyroids of TRbeta(PV/PV)Pten(+/-) mice. Our results indicate that PTEN deficiency resulted in increased cell proliferation and survival in the thyroids of TRbeta(PV/PV)Pten(+/-) mice. Altogether, our study provides direct evidence to indicate that in vivo, PTEN is a critical regulator in the follicular thyroid cancer progression and invasiveness. JF - Oncogene AU - Guigon, C J AU - Zhao, L AU - Willingham, M C AU - Cheng, S-Y AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. Y1 - 2009/01/29/ PY - 2009 DA - 2009 Jan 29 SP - 509 EP - 517 VL - 28 IS - 4 KW - Carrier Proteins KW - 0 KW - Ccnd1 protein, mouse KW - Forkhead Box Protein O3 KW - Forkhead Transcription Factors KW - FoxO3 protein, mouse KW - NF-kappa B KW - Thyroid Hormone Receptors beta KW - Cyclin D1 KW - 136601-57-5 KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Phosphotransferases (Alcohol Group Acceptor) KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - mTOR protein, mouse KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Ribosomal Protein S6 Kinases, 70-kDa KW - PTEN Phosphohydrolase KW - EC 3.1.3.67 KW - Pten protein, mouse KW - Casp3 protein, mouse KW - EC 3.4.22.- KW - Caspase 3 KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- genetics KW - Phosphatidylinositol 3-Kinases -- genetics KW - Animals KW - Carrier Proteins -- genetics KW - Disease Models, Animal KW - Cyclin D1 -- genetics KW - Cell Proliferation KW - Mice, Transgenic KW - Thyroid Hormone Receptors beta -- metabolism KW - Caspase 3 -- genetics KW - Apoptosis -- genetics KW - Forkhead Transcription Factors -- genetics KW - Cyclin D1 -- metabolism KW - Chromosomes, Mammalian -- genetics KW - Neoplasm Metastasis KW - Thyroid Hormone Receptors beta -- genetics KW - Phosphotransferases (Alcohol Group Acceptor) -- genetics KW - Caspase 3 -- metabolism KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Neoplasm Invasiveness KW - Carrier Proteins -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Cell Survival -- genetics KW - Mice KW - Ribosomal Protein S6 Kinases, 70-kDa -- metabolism KW - Chromosomes, Mammalian -- metabolism KW - Ribosomal Protein S6 Kinases, 70-kDa -- genetics KW - NF-kappa B -- genetics KW - Enzyme Activation -- genetics KW - Mice, Mutant Strains KW - Phosphotransferases (Alcohol Group Acceptor) -- metabolism KW - Forkhead Transcription Factors -- metabolism KW - NF-kappa B -- metabolism KW - Thyroid Neoplasms -- genetics KW - Thyroid Neoplasms -- metabolism KW - Lung Neoplasms -- secondary KW - Signal Transduction -- genetics KW - Lung Neoplasms -- genetics KW - Thyroid Neoplasms -- pathology KW - PTEN Phosphohydrolase -- metabolism KW - PTEN Phosphohydrolase -- genetics KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66865037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=PTEN+deficiency+accelerates+tumour+progression+in+a+mouse+model+of+thyroid+cancer.&rft.au=Guigon%2C+C+J%3BZhao%2C+L%3BWillingham%2C+M+C%3BCheng%2C+S-Y&rft.aulast=Guigon&rft.aufirst=C&rft.date=2009-01-29&rft.volume=28&rft.issue=4&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2008.407 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-17 N1 - Date created - 2009-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] J Surg Res. 2009 May 1;153(1):172-80 [18533190] Ann N Y Acad Sci. 2002 Jun;968:213-21 [12119278] Cancer Cell. 2002 Jul;2(1):81-91 [12150827] Biochim Biophys Acta. 2002 Oct 10;1584(2-3):73-80 [12385889] Mol Cell Biol. 2002 Nov;22(22):7842-52 [12391153] Thyroid. 2002 Nov;12(11):963-9 [12490073] Trends Endocrinol Metab. 2003 Sep;14(7):327-33 [12946875] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Mol Cell Endocrinol. 2003 Dec 31;213(1):31-45 [15062572] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Mol Endocrinol. 1992 Feb;6(2):248-58 [1569968] Science. 1997 Mar 28;275(5308):1943-7 [9072974] Nat Genet. 1997 Apr;15(4):356-62 [9090379] Nat Genet. 1997 May;16(1):64-7 [9140396] Nat Genet. 1997 Aug;16(4):333-4 [9241266] Hum Mol Genet. 1997 Aug;6(8):1383-7 [9259288] Diabetologia. 1997 Oct;40(10):1172-7 [9349598] Nat Genet. 1998 Aug;19(4):348-55 [9697695] Cancer. 1998 Sep 1;83(5):1012-21 [9731906] Presse Med. 1998 Oct 3;27(29):1479-81 [9798467] Curr Biol. 1998 Oct 22;8(21):1169-78 [9799734] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1563-8 [9990064] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Curr Opin Cell Biol. 2005 Apr;17(2):141-9 [15780590] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Oncogene. 2005 Nov 14;24(50):7410-25 [16288288] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] Oncogene. 2006 May 4;25(19):2736-47 [16314832] Cancer Res. 2007 Feb 1;67(3):959-66 [17283127] Int J Clin Pract. 2007 Apr;61(4):645-52 [17394437] Cancer Cell. 2007 Jul;12(1):9-22 [17613433] Carcinogenesis. 2007 Jul;28(7):1379-86 [17341655] PLoS One. 2007;2(11):e1237 [18043744] Carcinogenesis. 2007 Dec;28(12):2451-8 [17660507] Biochim Biophys Acta. 2008 Jan;1784(1):150-8 [17964232] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3583-8 [11248121] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/onc.2008.407 ER - TY - JOUR T1 - GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. AN - 66860437; 19164583 AB - Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the gastrointestinal tract in response to food intake. It enhances pancreatic islet beta-cell proliferation and glucose-dependent insulin secretion, and lowers blood glucose and food intake in patients with type 2 diabetes mellitus (T2DM). A long-acting GLP-1 receptor (GLP-1R) agonist, exendin-4 (Ex-4), is the first of this new class of antihyperglycemia drugs approved to treat T2DM. GLP-1Rs are coupled to the cAMP second messenger pathway and, along with pancreatic cells, are expressed within the nervous system of rodents and humans, where receptor activation elicits neurotrophic actions. We detected GLP-1R mRNA expression in both cultured embryonic primary cerebral cortical and ventral mesencephalic (dopaminergic) neurons. These cells are vulnerable to hypoxia- and 6-hydroxydopamine-induced cell death, respectively. We found that GLP-1 and Ex-4 conferred protection in these cells, but not in cells from Glp1r knockout (-/-) mice. Administration of Ex-4 reduced brain damage and improved functional outcome in a transient middle cerebral artery occlusion stroke model. Ex-4 treatment also protected dopaminergic neurons against degeneration, preserved dopamine levels, and improved motor function in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD). Our findings demonstrate that Ex-4 can protect neurons against metabolic and oxidative insults, and they provide preclinical support for the therapeutic potential for Ex-4 in the treatment of stroke and PD. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Li, Yazhou AU - Perry, TracyAnn AU - Kindy, Mark S AU - Harvey, Brandon K AU - Tweedie, David AU - Holloway, Harold W AU - Powers, Kathleen AU - Shen, Hui AU - Egan, Josephine M AU - Sambamurti, Kumar AU - Brossi, Arnold AU - Lahiri, Debomoy K AU - Mattson, Mark P AU - Hoffer, Barry J AU - Wang, Yun AU - Greig, Nigel H AD - Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA. Y1 - 2009/01/27/ PY - 2009 DA - 2009 Jan 27 SP - 1285 EP - 1290 VL - 106 IS - 4 KW - GLP1R protein, human KW - 0 KW - Glp1r protein, mouse KW - Glp1r protein, rat KW - Glucagon-Like Peptide-1 Receptor KW - Peptides KW - Receptors, Glucagon KW - Venoms KW - exenatide KW - 9P1872D4OL KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Humans KW - Cell Hypoxia -- drug effects KW - Disease Models, Animal KW - Mice KW - Peptides -- pharmacology KW - Mesencephalon -- cytology KW - Cell Death -- drug effects KW - Peptides -- therapeutic use KW - Brain Infarction -- pathology KW - Rats KW - Brain Infarction -- drug therapy KW - Venoms -- therapeutic use KW - Cells, Cultured KW - Embryo, Mammalian -- cytology KW - Treatment Outcome KW - Gene Expression Regulation -- drug effects KW - Venoms -- pharmacology KW - Stroke -- drug therapy KW - Stroke -- pathology KW - Neurons -- drug effects KW - Parkinson Disease -- metabolism KW - Stroke -- metabolism KW - Receptors, Glucagon -- genetics KW - Dopamine -- metabolism KW - Cytoprotection -- drug effects KW - Receptors, Glucagon -- metabolism KW - Parkinson Disease -- pathology KW - Parkinson Disease -- drug therapy KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66860437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=GLP-1+receptor+stimulation+preserves+primary+cortical+and+dopaminergic+neurons+in+cellular+and+rodent+models+of+stroke+and+Parkinsonism.&rft.au=Li%2C+Yazhou%3BPerry%2C+TracyAnn%3BKindy%2C+Mark+S%3BHarvey%2C+Brandon+K%3BTweedie%2C+David%3BHolloway%2C+Harold+W%3BPowers%2C+Kathleen%3BShen%2C+Hui%3BEgan%2C+Josephine+M%3BSambamurti%2C+Kumar%3BBrossi%2C+Arnold%3BLahiri%2C+Debomoy+K%3BMattson%2C+Mark+P%3BHoffer%2C+Barry+J%3BWang%2C+Yun%3BGreig%2C+Nigel+H&rft.aulast=Li&rft.aufirst=Yazhou&rft.date=2009-01-27&rft.volume=106&rft.issue=4&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0806720106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-13 N1 - Date created - 2009-01-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurology. 1999 Dec 10;53(9):1937-42 [10599761] J Neuroinflammation. 2008;5:19 [18492290] Exp Neurol. 2000 Nov;166(1):29-43 [11031081] J Pharmacol Exp Ther. 2002 Mar;300(3):958-66 [11861804] Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9521-6 [12093930] J Pharmacol Exp Ther. 2002 Sep;302(3):881-8 [12183643] Neuroscience. 2002;114(4):1005-17 [12379255] Ann Neurol. 2002 Nov;52(5):597-606 [12402257] J Biol Chem. 2003 Jan 3;278(1):471-8 [12409292] J Neurol Neurosurg Psychiatry. 2003 Mar;74(3):317-21 [12588915] J Neurosci. 2003 Apr 1;23(7):2939-46 [12684481] J Neurosci Res. 2003 Jun 1;72(5):603-12 [12749025] Trends Pharmacol Sci. 2003 Jul;24(7):377-83 [12871671] Nat Med. 2003 Sep;9(9):1173-9 [12925848] Lancet Neurol. 2004 Mar;3(3):169-78 [14980532] J Pharmacol Exp Ther. 2004 May;309(2):469-75 [14724226] Exp Neurol. 2004 Jun;187(2):478-86 [15144874] Arch Neurol. 2004 May;61(5):661-6 [15148141] Proc Natl Acad Sci U S A. 1985 Apr;82(7):2173-7 [3872460] Proc Natl Acad Sci U S A. 1988 Feb;85(4):1257-61 [2829221] Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10989-93 [8248201] Int J Neurosci. 1993 Mar-Apr;69(1-4):125-30 [8082998] J Biol Chem. 1995 Sep 15;270(37):21579-89 [7665571] J Neurochem. 1995 Dec;65(6):2612-20 [7595558] Nature. 1996 Jan 4;379(6560):69-72 [8538742] Eur J Neurosci. 1995 Nov 1;7(11):2294-300 [8563978] Neuroscience. 1996 Jan;70(2):329-39 [8848143] J Neurosci. 1997 Jan 1;17(1):83-90 [8987738] J Neurosci Methods. 1997 Apr 25;73(1):45-8 [9130677] Brain Res. 1997 Aug 15;765(2):301-12 [9313903] J Neurosci. 1998 Sep 15;18(18):7361-71 [9736656] Endocrinology. 1999 Mar;140(3):1132-40 [10067836] Clin Ther. 2005 Feb;27(2):210-5 [15811484] Curr Alzheimer Res. 2005 Jul;2(3):377-85 [15974903] Nature. 2006 Oct 19;443(7113):796-802 [17051206] Int J Biochem Cell Biol. 2007;39(3):497-504 [17074529] Exp Neurol. 2007 Feb;203(2):293-301 [17125767] J Neurosci Res. 2007 Mar;85(4):805-15 [17243171] Diabetes Care. 2007 Apr;30(4):842-7 [17251276] Gastroenterology. 2007 May;132(6):2131-57 [17498508] Aging Cell. 2007 Jun;6(3):337-50 [17328689] Stroke. 2007 Jun;38(6):1739-43 [17478738] J Neurosci Res. 2008 Feb 1;86(2):326-38 [17803225] Endocrinology. 2000 Apr;141(4):1301-9 [10746632] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0806720106 ER - TY - JOUR T1 - Long-term low level glucocorticoid exposure induces persistent repression in chromatin. AN - 66779564; 19007849 AB - Environmental exposure to low concentration hormones can have permanent epigenetic effects in animals and humans. The consequence of long-term low concentration glucocorticoid exposure was investigated in cell culture using glucocorticoid responsive genes organized in alternative chromatin structures. The MMTV promoter is induced by short-term glucocorticoid exposure on either an integrated (normal chromatin) or transient (unstructured chromatin) promoter. Longer hormone treatment causes a transient refractory repression of only the integrated promoter. Exposure to low concentrations of hormone for several passages persistently represses the integrated MMTV and endogenous glucocorticoid responsive promoters. The glucocorticoid receptor cannot bind to persistently repressed promoters. Induction by androgens is also inhibited on the repressed MMTV promoter. Similarly, osmotic stress induction of the endogenous Sgk gene is repressed. Persistent repression by glucocorticoids targets glucocorticoid responsive genes using a chromatin-dependent mechanism that disrupts binding of both GR-dependent and GR-independent transcription complexes. JF - Molecular and cellular endocrinology AU - Burkhart, Barbara A AU - Ivey, Melissa L AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2009/01/27/ PY - 2009 DA - 2009 Jan 27 SP - 66 EP - 75 VL - 298 IS - 1-2 SN - 0303-7207, 0303-7207 KW - Chromatin KW - 0 KW - Glucocorticoids KW - Multiprotein Complexes KW - Receptors, Glucocorticoid KW - Index Medicus KW - Gene Expression Profiling KW - Transcription, Genetic -- drug effects KW - Tumor Cells, Cultured KW - Promoter Regions, Genetic -- drug effects KW - Transfection KW - Humans KW - Down-Regulation -- drug effects KW - Time Factors KW - Receptors, Glucocorticoid -- physiology KW - Receptors, Glucocorticoid -- metabolism KW - Multiprotein Complexes -- metabolism KW - Mammary Tumor Virus, Mouse -- genetics KW - Glucocorticoids -- metabolism KW - Chromatin -- metabolism KW - Chromatin -- drug effects KW - Glucocorticoids -- pharmacology KW - Gene Silencing -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66779564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Long-term+low+level+glucocorticoid+exposure+induces+persistent+repression+in+chromatin.&rft.au=Burkhart%2C+Barbara+A%3BIvey%2C+Melissa+L%3BArcher%2C+Trevor+K&rft.aulast=Burkhart&rft.aufirst=Barbara&rft.date=2009-01-27&rft.volume=298&rft.issue=1-2&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=03037207&rft_id=info:doi/10.1016%2Fj.mce.2008.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-02 N1 - Date created - 2008-12-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 1998 Jan;12(1):45-56 [9440809] Int J Biochem Cell Biol. 2007;39(7-8):1500-9 [17499001] Am J Physiol Regul Integr Comp Physiol. 2005 Jan;288(1):R34-8 [15178540] Arch Immunol Ther Exp (Warsz). 2000;48(1):43-6 [10722231] Gynecol Oncol. 2000 Apr;77(1):177-82 [10739708] J Biol Chem. 2000 Jun 9;275(23):17771-7 [10748103] J Biol Chem. 2000 Aug 18;275(33):25262-72 [10842172] J Neuroendocrinol. 2001 Feb;13(2):113-28 [11168837] J Biol Chem. 2001 Mar 23;276(12):9273-8 [11108719] Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6865-70 [11381138] Mol Cell Biol. 2001 Aug;21(16):5417-25 [11463824] Neuropsychopharmacology. 2002 Aug;27(2):309-18 [12093605] Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E971-9 [12376324] Leukemia. 2003 Jan;17(1):17-25 [12529655] Mol Cell Biol. 2003 Feb;23(3):887-98 [12529394] Chromosoma. 2003 May;111(8):495-504 [12743713] Biochem Cell Biol. 2003 Jun;81(3):221-7 [12897856] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):30-45 [15020043] Mol Cell Biol. 2004 Apr;24(8):3347-58 [15060156] Ann N Y Acad Sci. 2004 Jun;1024:182-212 [15265782] Proc Natl Acad Sci U S A. 1986 May;83(10):3111-5 [3085084] Somat Cell Mol Genet. 1987 May;13(3):253-65 [2440117] Steroids. 1994 Jul;59(7):436-42 [7974528] Mol Endocrinol. 1994 Dec;8(12):1764-73 [7708063] J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):421-9 [7626491] Mol Cell Biol. 1997 Jun;17(6):3181-93 [9154817] Curr Opin Allergy Clin Immunol. 2005 Feb;5(1):23-9 [15643340] Annu Rev Physiol. 2005;67:259-84 [15709959] J Biol Chem. 2005 Feb 25;280(8):6349-58 [15556937] Mol Cell. 2005 Mar 18;17(6):805-15 [15780937] Curr Opin Allergy Clin Immunol. 2005 Jun;5(3):229-33 [15864080] Mol Cell Biol. 2005 May;25(10):3923-33 [15870267] Brain Behav Immun. 2005 Jul;19(4):296-308 [15944068] Proc Nutr Soc. 2005 May;64(2):143-51 [15960859] Anal Biochem. 2005 Dec 15;347(2):213-20 [16269125] Cell Tissue Res. 2005 Oct;322(1):81-8 [15846507] Mol Endocrinol. 2006 Jan;20(1):1-13 [16002433] J Steroid Biochem Mol Biol. 2006 Jul;100(1-3):34-41 [16723223] Ann N Y Acad Sci. 2006 Jul;1071:351-78 [16891583] Cancer Cell. 2006 Oct;10(4):331-42 [17010674] Exp Hematol. 2006 Nov;34(11):1542-52 [17046574] J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):222-31 [17045799] Biochemistry (Mosc). 2006 Oct;71(10):1073-81 [17125454] Brain Behav Immun. 2007 Jan;21(1):9-19 [17070667] J Nutr. 2007 Jan;137(1 Suppl):216S-222S [17182829] Mol Carcinog. 2007 Mar;46(3):187-97 [17219426] J Biol Chem. 2007 Mar 16;282(11):8284-91 [17186943] Mol Endocrinol. 2007 Apr;21(4):843-56 [17227884] EMBO J. 1998 Mar 2;17(5):1454-66 [9482742] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mce.2008.10.011 ER - TY - CPAPER T1 - Nitroimidazoles for TB: Mechanism of Killing T2 - 2009 Keystone Symposia on Tuberculosis: Biology, Pathology and Therapy (B3) AN - 41957048; 5114812 JF - 2009 Keystone Symposia on Tuberculosis: Biology, Pathology and Therapy (B3) AU - Boshoff, Helena Y1 - 2009/01/25/ PY - 2009 DA - 2009 Jan 25 KW - Nitroimidazoles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41957048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Tuberculosis%3A+Biology%2C+Pathology+and+Therapy+%28B3%29&rft.atitle=Nitroimidazoles+for+TB%3A+Mechanism+of+Killing&rft.au=Boshoff%2C+Helena&rft.aulast=Boshoff&rft.aufirst=Helena&rft.date=2009-01-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Tuberculosis%3A+Biology%2C+Pathology+and+Therapy+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rethinking the Concept of a Good TB Drug "Target" T2 - 2009 Keystone Symposia on Tuberculosis: Biology, Pathology and Therapy (B3) AN - 41941150; 5114820 JF - 2009 Keystone Symposia on Tuberculosis: Biology, Pathology and Therapy (B3) AU - Barry III, Clifton Y1 - 2009/01/25/ PY - 2009 DA - 2009 Jan 25 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41941150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Tuberculosis%3A+Biology%2C+Pathology+and+Therapy+%28B3%29&rft.atitle=Rethinking+the+Concept+of+a+Good+TB+Drug+%22Target%22&rft.au=Barry+III%2C+Clifton&rft.aulast=Barry+III&rft.aufirst=Clifton&rft.date=2009-01-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Tuberculosis%3A+Biology%2C+Pathology+and+Therapy+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=99 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RH5 determinant of P. falciparum virulence in Aotus T2 - 2009 Gordon Research Conference on Molecular Approaches for Emergent / Re-Emergent Tropical Diseases AN - 41924910; 5115608 JF - 2009 Gordon Research Conference on Molecular Approaches for Emergent / Re-Emergent Tropical Diseases AU - Wellems, Thomas Y1 - 2009/01/25/ PY - 2009 DA - 2009 Jan 25 KW - Virulence KW - Aotus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41924910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Molecular+Approaches+for+Emergent+%2F+Re-Emergent+Tropical+Diseases&rft.atitle=RH5+determinant+of+P.+falciparum+virulence+in+Aotus&rft.au=Wellems%2C+Thomas&rft.aulast=Wellems&rft.aufirst=Thomas&rft.date=2009-01-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Molecular+Approaches+for+Emergent+%2F+Re-Emergent+Tropical+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=molectrop LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Host - parasite interactions following transmission of Leishmania by sand fly bite T2 - 2009 Gordon Research Conference on Molecular Approaches for Emergent / Re-Emergent Tropical Diseases AN - 41924107; 5115610 JF - 2009 Gordon Research Conference on Molecular Approaches for Emergent / Re-Emergent Tropical Diseases AU - Sacks, David Y1 - 2009/01/25/ PY - 2009 DA - 2009 Jan 25 KW - Parasites KW - Bites KW - Sand KW - Hosts KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41924107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Molecular+Approaches+for+Emergent+%2F+Re-Emergent+Tropical+Diseases&rft.atitle=Host+-+parasite+interactions+following+transmission+of+Leishmania+by+sand+fly+bite&rft.au=Sacks%2C+David&rft.aulast=Sacks&rft.aufirst=David&rft.date=2009-01-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Molecular+Approaches+for+Emergent+%2F+Re-Emergent+Tropical+Diseases&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=molectrop LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How does Plasmodium evade the mosquito's immune system? T2 - 2009 Gordon Research Conference on Molecular Approaches for Emergent / Re-Emergent Tropical Diseases AN - 41917787; 5115612 JF - 2009 Gordon Research Conference on Molecular Approaches for Emergent / Re-Emergent Tropical Diseases AU - Barillas-Mury, Carolina Y1 - 2009/01/25/ PY - 2009 DA - 2009 Jan 25 KW - Immune system KW - Aquatic insects KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41917787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harvard+business+review&rft.atitle=The+path+to+corporate+responsibility.&rft.au=Zadek%2C+Simon&rft.aulast=Zadek&rft.aufirst=Simon&rft.date=2004-12-01&rft.volume=82&rft.issue=12&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Harvard+business+review&rft.issn=00178012&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=molectrop LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of multiple cellular targets in formalin-fi xed paraffi n embedded human tissue using streptavidin-conjugated quantum dots T2 - IV Conference on Colloidal Quantum Dots for Biomedical Applications (BO208) AN - 41741081; 5014102 JF - IV Conference on Colloidal Quantum Dots for Biomedical Applications (BO208) AU - Pittaluga, S AU - Wincovitch, Stephen Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Quantum dots KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41741081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=IV+Conference+on+Colloidal+Quantum+Dots+for+Biomedical+Applications+%28BO208%29&rft.atitle=Identification+of+multiple+cellular+targets+in+formalin-fi+xed+paraffi+n+embedded+human+tissue+using+streptavidin-conjugated+quantum+dots&rft.au=Pittaluga%2C+S%3BWincovitch%2C+Stephen&rft.aulast=Pittaluga&rft.aufirst=S&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=IV+Conference+on+Colloidal+Quantum+Dots+for+Biomedical+Applications+%28BO208%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A novel fast imaging modality for free radicals in vivo: continuous wave (CW) EPR imaging with direct detection and rapid fi eld scan in the presence of rotating gradients T2 - II Conference on Design and Quality for Biomedical Technologies (BO114) AN - 41733927; 5013167 JF - II Conference on Design and Quality for Biomedical Technologies (BO114) AU - Subramanian, Sankaran AU - Koscielniak, Janusz AU - Devasahayam, Nallathamby AU - Pursley, Randall AU - Pohida, Thomas AU - Krishna, Murali Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Imaging techniques KW - Free radicals KW - Waves KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41733927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Routine+diagnostic+X-ray+examinations+and+increased+frequency+of+chromosome+translocations+among+U.S.+radiologic+technologists.&rft.au=Sigurdson%2C+Alice+J%3BBhatti%2C+Parveen%3BPreston%2C+Dale+L%3BDoody%2C+Michele+Morin%3BKampa%2C+Diane%3BAlexander%2C+Bruce+H%3BPetibone%2C+Dayton%3BYong%2C+Lee+C%3BEdwards%2C+Alan+A%3BRon%2C+Elaine%3BTucker%2C+James+D&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2008-11-01&rft.volume=68&rft.issue=21&rft.spage=8825&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1691 L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activatable antibody-based NIR fl uorescence molecular imaging using various NIR fl uorophores T2 - 2009 Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (BO209) AN - 41731845; 5014122 JF - 2009 Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (BO209) AU - Kobayashi, Hisataka Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41731845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Environmental+politics&rft.atitle=The+civil+corporation%3A+the+new+economy+of+corporate+citizenship&rft.au=Zadek%2C+Simon%3BMorrison%2C+Mary&rft.aulast=Zadek&rft.aufirst=Simon&rft.date=2004-10-01&rft.volume=13&rft.issue=3&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Environmental+politics&rft.issn=09644016&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activatable optical imaging probes with various fl uorophorequencher combinations T2 - 2009 Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (BO209) AN - 41714266; 5014148 JF - 2009 Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (BO209) AU - Ogawa, Mikako AU - Kosaka, Nobuyuki AU - Urano, Yasuteru AU - Choyke, Peter AU - Kobayashi, Hisataka Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Probes KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41714266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Reporters%2C+Markers%2C+Dyes%2C+Nanoparticles%2C+and+Molecular+Probes+for+Biomedical+Applications+%28BO209%29&rft.atitle=Activatable+optical+imaging+probes+with+various+fl+uorophorequencher+combinations&rft.au=Ogawa%2C+Mikako%3BKosaka%2C+Nobuyuki%3BUrano%2C+Yasuteru%3BChoyke%2C+Peter%3BKobayashi%2C+Hisataka&rft.aulast=Ogawa&rft.aufirst=Mikako&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Reporters%2C+Markers%2C+Dyes%2C+Nanoparticles%2C+and+Molecular+Probes+for+Biomedical+Applications+%28BO209%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Assessment of Hand Vasculature Using Infrared and Laser Speckle Imaging T2 - VII Conference on Advanced Biomedical and Clinical Diagnostic Systems (BO113) AN - 41704418; 5013075 JF - VII Conference on Advanced Biomedical and Clinical Diagnostic Systems (BO113) AU - Gorbach, Alexander AU - Wang, Hengliang Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Lasers KW - Imaging techniques KW - Hand KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41704418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=VII+Conference+on+Advanced+Biomedical+and+Clinical+Diagnostic+Systems+%28BO113%29&rft.atitle=Functional+Assessment+of+Hand+Vasculature+Using+Infrared+and+Laser+Speckle+Imaging&rft.au=Gorbach%2C+Alexander%3BWang%2C+Hengliang&rft.aulast=Gorbach&rft.aufirst=Alexander&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=VII+Conference+on+Advanced+Biomedical+and+Clinical+Diagnostic+Systems+%28BO113%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Meeting current public health needs: optical biosensors for pathogen detection and analysis T2 - 2009 Conference on Frontiers in Pathogen Detection: From Nanosensors to Systems (BO111) AN - 41704135; 5012857 JF - 2009 Conference on Frontiers in Pathogen Detection: From Nanosensors to Systems (BO111) AU - Rasooly, Avraham Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Public health KW - Pathogens KW - Biosensors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41704135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Frontiers+in+Pathogen+Detection%3A+From+Nanosensors+to+Systems+%28BO111%29&rft.atitle=Meeting+current+public+health+needs%3A+optical+biosensors+for+pathogen+detection+and+analysis&rft.au=Rasooly%2C+Avraham&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Frontiers+in+Pathogen+Detection%3A+From+Nanosensors+to+Systems+%28BO111%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative analysis of HER2 expression in vivo by near-infrared optical imaging T2 - 2009 Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (BO209) AN - 41693884; 5014121 JF - 2009 Conference on Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications (BO209) AU - Chernomordik, Victor AU - Hassan, Moinuddin AU - Lee, Sang-Bong AU - Capala, Jacek AU - Gandjbakhche, Amir Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Quantitative analysis KW - I.R. radiation KW - Imaging techniques KW - ErbB-2 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41693884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Conference+on+Reporters%2C+Markers%2C+Dyes%2C+Nanoparticles%2C+and+Molecular+Probes+for+Biomedical+Applications+%28BO209%29&rft.atitle=Quantitative+analysis+of+HER2+expression+in+vivo+by+near-infrared+optical+imaging&rft.au=Chernomordik%2C+Victor%3BHassan%2C+Moinuddin%3BLee%2C+Sang-Bong%3BCapala%2C+Jacek%3BGandjbakhche%2C+Amir&rft.aulast=Chernomordik&rft.aufirst=Victor&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Conference+on+Reporters%2C+Markers%2C+Dyes%2C+Nanoparticles%2C+and+Molecular+Probes+for+Biomedical+Applications+%28BO209%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Towards Quantitative Bedside Kaposi'S Sarcoma Imaging T2 - VIII Conference on Optical Tomography and Spectroscopy of Tissues (BO118) AN - 41690091; 5013342 JF - VIII Conference on Optical Tomography and Spectroscopy of Tissues (BO118) AU - Kainerstorfer, Jana AU - Amyot, Franck AU - Riley, Jason AU - Hassan, Moinuddin AU - Chernomordik, Victor AU - Yarchoan, Robert AU - Hitzenberger, Christoph AU - Gandjbakhche, Amir Y1 - 2009/01/24/ PY - 2009 DA - 2009 Jan 24 KW - Imaging techniques KW - Kaposi's sarcoma KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41690091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=VIII+Conference+on+Optical+Tomography+and+Spectroscopy+of+Tissues+%28BO118%29&rft.atitle=Towards+Quantitative+Bedside+Kaposi%27S+Sarcoma+Imaging&rft.au=Kainerstorfer%2C+Jana%3BAmyot%2C+Franck%3BRiley%2C+Jason%3BHassan%2C+Moinuddin%3BChernomordik%2C+Victor%3BYarchoan%2C+Robert%3BHitzenberger%2C+Christoph%3BGandjbakhche%2C+Amir&rft.aulast=Kainerstorfer&rft.aufirst=Jana&rft.date=2009-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=VIII+Conference+on+Optical+Tomography+and+Spectroscopy+of+Tissues+%28BO118%29&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2009-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - How close is the bench to the bedside? Metabolic profiling in cancer research. AN - 734236532; 19348692 AB - Metabolic profiling using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) is integral to the rapidly expanding field of metabolomics, which is making progress in toxicology, plant science and various diseases, including cancer. In the area of oncology and metabolic phenotyping, researchers have probed the known changes in malignant cellular pathways using new experimental techniques to gain more insights, and others are exploiting these same cellular pathways for therapeutic drug targets and for novel cancer biomarkers, with the ultimate goal of translation to the clinic. Here, we discuss the challenges and opportunities in metabolic phenotyping for discovering novel cancer biomarkers, and we assess the clinical applicability of MS and NMR. JF - Genome medicine AU - Van, Que N AU - Veenstra, Timothy D AD - Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 SP - 5 VL - 1 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734236532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+medicine&rft.atitle=How+close+is+the+bench+to+the+bedside%3F+Metabolic+profiling+in+cancer+research.&rft.au=Van%2C+Que+N%3BVeenstra%2C+Timothy+D&rft.aulast=Van&rft.aufirst=Que&rft.date=2009-01-20&rft.volume=1&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Genome+medicine&rft.issn=1756-994X&rft_id=info:doi/10.1186%2Fgm5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2010-01-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Rev Cancer. 2004 Jul;4(7):551-61 [15229480] Proc Natl Acad Sci U S A. 1986 May;83(10):3166-70 [2422647] Oncology. 2000 Nov;59(4):269-82 [11096338] J Magn Reson. 2000 Jun;144(2):357-66 [10828203] Nat Med. 2008 Aug;14(8):869-74 [18607350] Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1653-7 [18628416] Cancer Cell. 2008 Jun;13(6):472-82 [18538731] Int J Gynecol Cancer. 2008 May-Jun;18(3):465-9 [17868343] Clin Biochem. 2008 Jun;41(9):649-62 [18374660] Prostate. 2008 May 1;68(6):620-8 [18213632] Radiat Res. 2008 Feb;169(2):170-80 [18220461] Anal Chem. 2008 Feb 1;80(3):665-74 [18173289] Curr Oncol Rep. 2007 Nov;9(6):485-93 [17991357] Expert Opin Ther Targets. 2007 Aug;11(8):1055-69 [17665978] Expert Rev Proteomics. 2007 Jun;4(3):389-400 [17552923] J Am Chem Soc. 2007 Apr 25;129(16):5108-16 [17388596] Radiol Clin North Am. 2007 Jan;45(1):149-66 [17157627] Cancer Res. 2006 Nov 15;66(22):10795-804 [17108116] J Urol. 2006 Nov;176(5):2274-9 [17070311] Clin Biochem. 2006 Apr;39(4):315-32 [16563365] Anal Chem. 2006 Apr 1;78(7):2199-208 [16579598] J Exp Biol. 2005 Dec;208(Pt 24):4561-75 [16326938] Anal Chem. 2005 Oct 15;77(20):6646-54 [16223252] J Biomol NMR. 2005 Jun;32(2):141-50 [16034665] Clin Chem. 1997 Sep;43(9):1588-94 [9299938] Chem Res Toxicol. 2002 Nov;15(11):1380-6 [12437328] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/gm5 ER - TY - CPAPER T1 - Targets of IL-13 Signaling in Inflammation and Fibrosis T2 - 2009 Keystone Symposia on Fibrosis (J2) AN - 41912307; 5113611 JF - 2009 Keystone Symposia on Fibrosis (J2) AU - Wynn, Thomas Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 KW - Signal transduction KW - Fibrosis KW - Inflammation KW - Interleukin 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41912307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Fibrosis+%28J2%29&rft.atitle=Targets+of+IL-13+Signaling+in+Inflammation+and+Fibrosis&rft.au=Wynn%2C+Thomas&rft.aulast=Wynn&rft.aufirst=Thomas&rft.date=2009-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Fibrosis+%28J2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Glucocorticoid Receptor: One Gene, Many Proteins - New Mechanisms for Tissue Specific Anti-Inflammatory Actions of Glucocorticoids in Health and Disease T2 - 2009 Keystone Symposia on Allergy and Asthma (J1) AN - 41906780; 5114537 JF - 2009 Keystone Symposia on Allergy and Asthma (J1) AU - Cidlowski, John Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 KW - Glucocorticoids KW - Inflammation KW - Glucocorticoid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41906780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Allergy+and+Asthma+%28J1%29&rft.atitle=The+Glucocorticoid+Receptor%3A+One+Gene%2C+Many+Proteins+-+New+Mechanisms+for+Tissue+Specific+Anti-Inflammatory+Actions+of+Glucocorticoids+in+Health+and+Disease&rft.au=Cidlowski%2C+John&rft.aulast=Cidlowski&rft.aufirst=John&rft.date=2009-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Allergy+and+Asthma+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sphingosine-1-Phosphate in Allergy and Asthma T2 - 2009 Keystone Symposia on Allergy and Asthma (J1) AN - 41906426; 5114534 JF - 2009 Keystone Symposia on Allergy and Asthma (J1) AU - Rivera, Juan Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 KW - Respiratory diseases KW - Asthma KW - Sphingosine 1-phosphate KW - Hypersensitivity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41906426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Allergy+and+Asthma+%28J1%29&rft.atitle=Sphingosine-1-Phosphate+in+Allergy+and+Asthma&rft.au=Rivera%2C+Juan&rft.aulast=Rivera&rft.aufirst=Juan&rft.date=2009-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Allergy+and+Asthma+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGF-beta in the Development of CD4+ Foxp3+ Regulatory T Cells and the Regulation of House Dust Mite Induced Asthma T2 - 2009 Keystone Symposia on Allergy and Asthma (J1) AN - 41905140; 5114527 JF - 2009 Keystone Symposia on Allergy and Asthma (J1) AU - Chen, Wanjun Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 KW - Mites KW - Respiratory diseases KW - Asthma KW - House dust KW - Lymphocytes T KW - Immunoregulation KW - Foxp3 protein KW - CD4 antigen KW - Transforming growth factor-b KW - Dust KW - Dermatophagoides pteronyssinus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41905140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Allergy+and+Asthma+%28J1%29&rft.atitle=TGF-beta+in+the+Development+of+CD4%2B+Foxp3%2B+Regulatory+T+Cells+and+the+Regulation+of+House+Dust+Mite+Induced+Asthma&rft.au=Chen%2C+Wanjun&rft.aulast=Chen&rft.aufirst=Wanjun&rft.date=2009-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Allergy+and+Asthma+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Homeostatic Control of Basophil GATA-3 Expression and TH2 Differentiation by Lyn Kinase T2 - 2009 Keystone Symposia on Allergy and Asthma (J1) AN - 41904822; 5114526 JF - 2009 Keystone Symposia on Allergy and Asthma (J1) AU - Charles, Nicolas Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 KW - Differentiation KW - Lymphocytes T KW - GATA-3 protein KW - Leukocytes (basophilic) KW - Lyn protein KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41904822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Allergy+and+Asthma+%28J1%29&rft.atitle=Homeostatic+Control+of+Basophil+GATA-3+Expression+and+TH2+Differentiation+by+Lyn+Kinase&rft.au=Charles%2C+Nicolas&rft.aulast=Charles&rft.aufirst=Nicolas&rft.date=2009-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Allergy+and+Asthma+%28J1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accelerated Liver Fibrosis in the Combined Absence of Interleukin-13 Regulatory Molecules: IL-13 Receptor Alpha 2, IL-10 and IL-12 T2 - 2009 Keystone Symposia on Fibrosis (J2) AN - 41898275; 5113609 JF - 2009 Keystone Symposia on Fibrosis (J2) AU - Mentink-Kane, Margaret Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 KW - Liver KW - Interleukin 13 KW - Interleukin 10 KW - Fibrosis KW - Interleukin 12 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Fibrosis+%28J2%29&rft.atitle=Accelerated+Liver+Fibrosis+in+the+Combined+Absence+of+Interleukin-13+Regulatory+Molecules%3A+IL-13+Receptor+Alpha+2%2C+IL-10+and+IL-12&rft.au=Mentink-Kane%2C+Margaret&rft.aulast=Mentink-Kane&rft.aufirst=Margaret&rft.date=2009-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Fibrosis+%28J2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Renal Fibrosis T2 - 2009 Keystone Symposia on Fibrosis (J2) AN - 41893253; 5113623 JF - 2009 Keystone Symposia on Fibrosis (J2) AU - Kopp, Jeffrey Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 KW - Reviews KW - Fibrosis KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41893253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Fibrosis+%28J2%29&rft.atitle=Overview+of+Renal+Fibrosis&rft.au=Kopp%2C+Jeffrey&rft.aulast=Kopp&rft.aufirst=Jeffrey&rft.date=2009-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Fibrosis+%28J2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The promoter spacer influences transcription initiation via Ie super(70) region 1.1 of Escherichia coli RNA polymerase AN - 20237173; 10313241 AB - Transcription initiation is a dynamic process in which RNA polymerase (RNAP) and promoter DNA act as partners, changing in response to one another, to produce a polymerase/promoter open complex (RPo) competent for transcription. In Escherichia coli RNAP, region 1.1, the N-terminal 100 residues of Ie super(70), is thought to occupy the channel that will hold the DNA downstream of the transcription start site; thus, region 1.1 must move from this channel as RPo is formed. Previous work has also shown that region 1.1 can modulate RPo formation depending on the promoter. For some promoters region 1.1 stimulates the formation of open complexes; at the P sub(minor) promoter, region 1.1 inhibits this formation. We demonstrate here that the AT-rich P sub(minor) spacer sequence, rather than promoter recognition elements or downstream DNA, determines the effect of region 1.1 on promoter activity. Using a P sub(minor) derivative that contains good Ie super(70)-dependent DNA elements, we find that the presence of a more GC-rich spacer or a spacer with the complement of the P sub(minor) sequence results in a promoter that is no longer inhibited by region 1.1. Furthermore, the presence of the P sub(minor) spacer, the GC-rich spacer, or the complement spacer results in different mobilities of promoter DNA during gel electrophoresis, suggesting that the spacer regions impart differing conformations or curvatures to the DNA. We speculate that the spacer can influence the trajectory or flexibility of DNA as it enters the RNAP channel and that region 1.1 acts as a 'oegatekeeper' to monitor channel entry. JF - Proceedings of the National Academy of Sciences, USA AU - Hook-Barnard, India G AU - Hinton, Deborah M AD - Gene Expression and Regulation Section, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, dhinton@helix.nih.gov Y1 - 2009/01/20/ PY - 2009 DA - 2009 Jan 20 SP - 737 EP - 742 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 3 SN - 0027-8424, 0027-8424 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Promoters KW - DNA-directed RNA polymerase KW - Spacer region KW - Nucleotide sequence KW - Escherichia coli KW - DNA KW - Electrophoretic mobility KW - Gel electrophoresis KW - Transcription initiation KW - Conformation KW - J 02320:Cell Biology KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20237173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=The+promoter+spacer+influences+transcription+initiation+via+Ie+super%2870%29+region+1.1+of+Escherichia+coli+RNA+polymerase&rft.au=Hook-Barnard%2C+India+G%3BHinton%2C+Deborah+M&rft.aulast=Hook-Barnard&rft.aufirst=India&rft.date=2009-01-20&rft.volume=106&rft.issue=3&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0808133106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Promoters; Spacer region; DNA-directed RNA polymerase; Nucleotide sequence; DNA; Electrophoretic mobility; Gel electrophoresis; Conformation; Transcription initiation; Escherichia coli DO - http://dx.doi.org/10.1073/pnas.0808133106 ER - TY - CPAPER T1 - Altered O-GlcNAc cycling impacts nucleotide sugar metabolism, macronutrient storage and expression of C-type lectins T2 - 2009 Gordon Research Conference on Glycobiology AN - 41947551; 5116440 JF - 2009 Gordon Research Conference on Glycobiology AU - Ghosh, Salil Y1 - 2009/01/18/ PY - 2009 DA - 2009 Jan 18 KW - Metabolism KW - Storage KW - Lectins KW - Sugar KW - Nucleotides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41947551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Gordon+Research+Conference+on+Glycobiology&rft.atitle=Altered+O-GlcNAc+cycling+impacts+nucleotide+sugar+metabolism%2C+macronutrient+storage+and+expression+of+C-type+lectins&rft.au=Ghosh%2C+Salil&rft.aulast=Ghosh&rft.aufirst=Salil&rft.date=2009-01-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Gordon+Research+Conference+on+Glycobiology&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2009&program=glycobio LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016. AN - 66826733; 19147766 AB - Poly (ADP-ribose) polymerase (PARP) inhibitors are undergoing clinical evaluation for cancer therapy. Because PARP inhibition has been shown to enhance tumor cell sensitivity to radiation, we investigated the in vitro and in vivo effects of the novel PARP inhibitor E7016. The effect of E7016 on the in vitro radiosensitivity of tumor cell lines was evaluated using clonogenic survival. DNA damage and repair were measured using gammaH2AX foci and neutral comet assay. Mitotic catastrophe was determined by immunostaining. Tumor growth delay was evaluated in mice for the effect of E7016 on in vivo (U251) tumor radiosensitivity. Cell lines exposed to E7016 preirradiation yielded an increase in radiosensitivity with dose enhancement factors at a surviving fraction of 0.1 from 1.4 to 1.7. To assess DNA double-strand breaks repair, gammaH2AX measured at 24 hours postirradiation had significantly more foci per cell in the E7016/irradiation group versus irradiation alone. Neutral comet assay further suggested unrepaired double-strand breaks with significantly greater DNA damage at 6 hours postirradiation in the combination group versus irradiation alone. Mitotic catastrophe staining revealed a significantly greater number of cells staining positive at 24 hours postirradiation in the combination group. In vivo, mice treated with E7016/irradiation/temozolomide had an additional growth delay of six days compared with the combination of temozolomide and irradiation. These results indicate that E7016 can enhance tumor cell radiosensitivity in vitro and in vivo through the inhibition of DNA repair. Moreover, enhanced growth delay with the addition of E7016 to temozolomide and radiotherapy in a glioma mouse model suggests a potential role for this drug in the treatment of glioblastoma multiforme. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Russo, Andrea L AU - Kwon, Hyuk-Chan AU - Burgan, William E AU - Carter, Donna AU - Beam, Katie AU - Weizheng, Xu AU - Zhang, Jie AU - Slusher, Barbara S AU - Chakravarti, Arnab AU - Tofilon, Philip J AU - Camphausen, Kevin AD - Radiation Oncology Branch, National Cancer Institute, 10 Center Drive 3B42, Bethesda, MD, USA. Y1 - 2009/01/15/ PY - 2009 DA - 2009 Jan 15 SP - 607 EP - 612 VL - 15 IS - 2 SN - 1078-0432, 1078-0432 KW - Enzyme Inhibitors KW - 0 KW - Poly(ADP-ribose) Polymerase Inhibitors KW - Dacarbazine KW - 7GR28W0FJI KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - temozolomide KW - YF1K15M17Y KW - Index Medicus KW - Animals KW - Comet Assay KW - Apoptosis KW - DNA Repair KW - Humans KW - Cell Line, Tumor KW - Mice KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Dacarbazine -- analogs & derivatives KW - Dacarbazine -- pharmacology KW - Mitosis KW - In Vitro Techniques KW - Radiotherapy -- methods KW - Brain Neoplasms -- drug therapy KW - Enzyme Inhibitors -- pharmacology KW - Glioblastoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66826733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=In+vitro+and+in+vivo+radiosensitization+of+glioblastoma+cells+by+the+poly+%28ADP-ribose%29+polymerase+inhibitor+E7016.&rft.au=Russo%2C+Andrea+L%3BKwon%2C+Hyuk-Chan%3BBurgan%2C+William+E%3BCarter%2C+Donna%3BBeam%2C+Katie%3BWeizheng%2C+Xu%3BZhang%2C+Jie%3BSlusher%2C+Barbara+S%3BChakravarti%2C+Arnab%3BTofilon%2C+Philip+J%3BCamphausen%2C+Kevin&rft.aulast=Russo&rft.aufirst=Andrea&rft.date=2009-01-15&rft.volume=15&rft.issue=2&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-08-2079 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-20 N1 - Date created - 2009-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-08-2079 ER - TY - JOUR T1 - Type of alcoholic beverage and risk of head and neck cancer--a pooled analysis within the INHANCE Consortium. AN - 66811676; 19064644 AB - The authors pooled data from 15 case-control studies of head and neck cancer (9,107 cases, 14,219 controls) to investigate the independent associations with consumption of beer, wine, and liquor. In particular, they calculated associations with different measures of beverage consumption separately for subjects who drank beer only (858 cases, 986 controls), for liquor-only drinkers (499 cases, 527 controls), and for wine-only drinkers (1,021 cases, 2,460 controls), with alcohol never drinkers (1,124 cases, 3,487 controls) used as a common reference group. The authors observed similar associations with ethanol-standardized consumption frequency for beer-only drinkers (odds ratios (ORs) = 1.6, 1.9, 2.2, and 5.4 for 30 drinks per week, respectively; P(trend) < 0.0001) and liquor-only drinkers (ORs = 1.6, 1.5, 2.3, and 3.6; P < 0.0001). Among wine-only drinkers, the odds ratios for moderate levels of consumption frequency approached the null, whereas those for higher consumption levels were comparable to those of drinkers of other beverage types (ORs = 1.1, 1.2, 1.9, and 6.3; P < 0.0001). Study findings suggest that the relative risks of head and neck cancer for beer and liquor are comparable. The authors observed weaker associations with moderate wine consumption, although they cannot rule out confounding from diet and other lifestyle factors as an explanation for this finding. Given the presence of heterogeneity in study-specific results, their findings should be interpreted with caution. JF - American journal of epidemiology AU - Purdue, Mark P AU - Hashibe, Mia AU - Berthiller, Julien AU - La Vecchia, Carlo AU - Dal Maso, Luigino AU - Herrero, Rolando AU - Franceschi, Silvia AU - Castellsague, Xavier AU - Wei, Qingyi AU - Sturgis, Erich M AU - Morgenstern, Hal AU - Zhang, Zuo-Feng AU - Levi, Fabio AU - Talamini, Renato AU - Smith, Elaine AU - Muscat, Joshua AU - Lazarus, Philip AU - Schwartz, Stephen M AU - Chen, Chu AU - Neto, Jose Eluf AU - Wünsch-Filho, Victor AU - Zaridze, David AU - Koifman, Sergio AU - Curado, Maria Paula AU - Benhamou, Simone AU - Matos, Elena AU - Szeszenia-Dabrowska, Neonilia AU - Olshan, Andrew F AU - Lence, Juan AU - Menezes, Ana AU - Daudt, Alexander W AU - Mates, Ioan Nicolae AU - Pilarska, Agnieszka AU - Fabianova, Eleonora AU - Rudnai, Peter AU - Winn, Debbie AU - Ferro, Gilles AU - Brennan, Paul AU - Boffetta, Paolo AU - Hayes, Richard B AD - National Cancer Institute, Bethesda, Maryland, USA. purduem@mail.nih.gov Y1 - 2009/01/15/ PY - 2009 DA - 2009 Jan 15 SP - 132 EP - 142 VL - 169 IS - 2 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Odds Ratio KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Beer -- adverse effects KW - Wine -- adverse effects KW - Risk Assessment KW - Ethanol -- adverse effects KW - Head and Neck Neoplasms -- etiology KW - Alcohol Drinking -- adverse effects KW - Head and Neck Neoplasms -- chemically induced KW - Alcoholic Beverages -- adverse effects KW - Head and Neck Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66811676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Type+of+alcoholic+beverage+and+risk+of+head+and+neck+cancer--a+pooled+analysis+within+the+INHANCE+Consortium.&rft.au=Purdue%2C+Mark+P%3BHashibe%2C+Mia%3BBerthiller%2C+Julien%3BLa+Vecchia%2C+Carlo%3BDal+Maso%2C+Luigino%3BHerrero%2C+Rolando%3BFranceschi%2C+Silvia%3BCastellsague%2C+Xavier%3BWei%2C+Qingyi%3BSturgis%2C+Erich+M%3BMorgenstern%2C+Hal%3BZhang%2C+Zuo-Feng%3BLevi%2C+Fabio%3BTalamini%2C+Renato%3BSmith%2C+Elaine%3BMuscat%2C+Joshua%3BLazarus%2C+Philip%3BSchwartz%2C+Stephen+M%3BChen%2C+Chu%3BNeto%2C+Jose+Eluf%3BW%C3%BCnsch-Filho%2C+Victor%3BZaridze%2C+David%3BKoifman%2C+Sergio%3BCurado%2C+Maria+Paula%3BBenhamou%2C+Simone%3BMatos%2C+Elena%3BSzeszenia-Dabrowska%2C+Neonilia%3BOlshan%2C+Andrew+F%3BLence%2C+Juan%3BMenezes%2C+Ana%3BDaudt%2C+Alexander+W%3BMates%2C+Ioan+Nicolae%3BPilarska%2C+Agnieszka%3BFabianova%2C+Eleonora%3BRudnai%2C+Peter%3BWinn%2C+Debbie%3BFerro%2C+Gilles%3BBrennan%2C+Paul%3BBoffetta%2C+Paolo%3BHayes%2C+Richard+B&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2009-01-15&rft.volume=169&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn306 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-09 N1 - Date created - 2009-01-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1999 Dec 1;150(11):1129-37 [10588073] J Natl Cancer Inst. 2007 May 16;99(10):777-89 [17505073] Cancer Epidemiol Biomarkers Prev. 2000 Feb;9(2):185-91 [10698480] J Oral Pathol Med. 2000 Feb;29(2):80-5 [10718403] Int J Cancer. 2000 Apr 1;86(1):144-9 [10728609] Br J Cancer. 2001 Jul 6;85(1):46-54 [11437401] Stat Med. 2001 Jul 30;20(14):2115-30 [11439425] Cancer Causes Control. 2001 Sep;12(7):579-87 [11552705] Carcinogenesis. 2002 Jul;23(7):1229-34 [12117782] Int J Cancer. 2002 Dec 1;102(4):435-7 [12402316] Am J Epidemiol. 2003 May 15;157(10):881-7 [12746240] J Natl Cancer Inst. 2003 Dec 3;95(23):1772-83 [14652239] Int J Cancer. 2004 Feb 20;108(5):741-9 [14696101] Cancer Res. 2004 Jun 1;64(11):4049-54 [15173020] IARC Monogr Eval Carcinog Risks Hum. 2004;83:1-1438 [15285078] Oral Oncol. 2004 Oct;40(9):904-9 [15380168] Int J Cancer. 2004 Dec 10;112(5):901-4 [15386379] J Oral Pathol. 1986 May;15(5):276-9 [3091795] Cancer Res. 1988 Jun 1;48(11):3282-7 [3365707] Int J Cancer. 1989 Feb 15;43(2):190-4 [2917798] IARC Monogr Eval Carcinog Risks Hum. 1988;44:1-378 [3236394] Cancer Res. 1989 Sep 1;49(17):4919-24 [2758421] Cancer Res. 1990 Oct 15;50(20):6502-7 [2208109] Int J Cancer. 1990 Dec 15;46(6):1017-20 [2249890] Br J Addict. 1990 Oct;85(10):1279-89 [2265288] Cancer. 1993 Aug 15;72(4):1369-75 [8339227] Addiction. 1993 Oct;88(10):1391-404 [8251877] Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec;2(6):519-23 [8268767] Cancer Causes Control. 1995 Jan;6(1):57-67 [7718736] Am J Epidemiol. 1995 Dec 15;142(12):1255-64 [7503045] Int J Epidemiol. 1996 Aug;25(4):775-82 [8921456] Cancer Causes Control. 1998 Jan;9(1):99-108 [9486469] Int J Cancer. 1998 Aug 31;77(5):705-9 [9688303] BMJ. 1998 Sep 26;317(7162):844-7 [9748175] Br J Oral Maxillofac Surg. 1998 Aug;36(4):247-51 [9762451] Am J Clin Nutr. 1999 Jan;69(1):49-54 [9925122] Cancer Causes Control. 1999 Feb;10(1):27-33 [10334639] Anticancer Res. 2004 Sep-Oct;24(5A):2783-840 [15517885] Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):626-32 [15767341] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1188-93 [15894670] Int J Cancer. 2006 Feb 1;118(3):714-20 [16094634] BMJ. 2006 Mar 4;332(7540):519-22 [16428251] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):696-703 [16614111] Am J Epidemiol. 1999 Dec 1;150(11):1138-40; discussion 1141 [10588074] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn306 ER - TY - JOUR T1 - Delta-opioid receptor antagonists prevent sensitization to the conditioned rewarding effects of morphine. AN - 66779332; 18950747 AB - Functional interactions between mu- and delta-opioid receptors (MOPr and DOPr, respectively) are implicated in morphine tolerance and dependence. The contribution of DOPr to the conditioned rewarding effects of morphine and the enhanced conditioned response that occurs after repeated morphine administration is unknown. This issue was addressed with the conditioned place preference procedure (CPP). Rats received home cage injections of saline or morphine (5.0 mg/kg/day x 5 days) before conditioning. For sensitization studies, DOPr antagonists (DOPr1/2: naltrindole, DOPr2: naltriben, DOPr1: 7-benzylidenenaltrexone) were administered before morphine injections. Conditioning sessions (2 morphine; 2 saline) commenced 3 days later. To assess the influence of acute DOPr blockade on the conditioning of morphine reward in naïve animals, 3 morphine and 3 saline conditioning sessions were employed. Antagonists were administered before morphine conditioning sessions. Morphine was ineffective as a conditioning stimulus after two conditioning sessions in naïve rats. However, doses > or = 3.0 mg/kg produced significant CPP in morphine pre-exposed rats, confirming that sensitization develops to the conditioned rewarding effects of morphine. In animals that received morphine pre-exposure with naltrindole or naltriben but not 7-benzylidenenaltrexone, sensitization was prevented. No attenuation of morphine CPP was observed in animals that received DOPr antagonists acutely, before conditioning sessions. These data indicate a critical role of DOPr systems in mediating sensitization to the conditioned rewarding effects of morphine. The efficacy of naltrindole and naltriben in preventing the enhanced response to morphine suggest the specific involvement of DOPr2 in the sensitization process. JF - Biological psychiatry AU - Shippenberg, Toni S AU - Chefer, Vladimir I AU - Thompson, Alexis C AD - Integrative Neuroscience Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/US DHHS, 333 Cassell Dr., Baltimore, MD 21224, USA. tshippen@intra.nida.nih.gov Y1 - 2009/01/15/ PY - 2009 DA - 2009 Jan 15 SP - 169 EP - 174 VL - 65 IS - 2 KW - Benzylidene Compounds KW - 0 KW - Narcotic Antagonists KW - Receptors, Opioid, delta KW - Receptors, Opioid, mu KW - naltrindole benzofuran KW - 111555-58-9 KW - 7-benzylidenenaltrexone KW - 129468-28-6 KW - Naltrexone KW - 5S6W795CQM KW - naltrindole KW - G167Z38QA4 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Receptors, Opioid, delta -- antagonists & inhibitors KW - Naltrexone -- analogs & derivatives KW - Disease Models, Animal KW - Benzylidene Compounds -- pharmacology KW - Receptor Cross-Talk -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Naltrexone -- pharmacology KW - Receptors, Opioid, mu -- drug effects KW - Statistics, Nonparametric KW - Male KW - Behavior, Animal -- drug effects KW - Morphine Dependence -- physiopathology KW - Association Learning -- drug effects KW - Reinforcement (Psychology) KW - Conditioning, Classical -- drug effects KW - Narcotic Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66779332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Zadek%2C+Simon%3BHojensgard%2C+Niels%3BRaynard%2C+Peter&rft.aulast=Zadek&rft.aufirst=Simon&rft.date=2001-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=8798816101&rft.btitle=Perspectives+on+the+new+economy+of+corporate+citizenship&rft.title=Perspectives+on+the+new+economy+of+corporate+citizenship&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2008-12-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 1985;86(3):274-80 [2994144] J Med Chem. 2004 Jun 3;47(12):2969-72 [15163177] Psychopharmacology (Berl). 1989;98(3):357-62 [2546170] Psychopharmacology (Berl). 1991;103(2):183-6 [2027919] J Pharmacol Exp Ther. 1991 May;257(2):676-80 [1851833] J Pharmacol Exp Ther. 1991 Jul 1;258(1):299-303 [1649297] Life Sci. 1992;50(20):1491-5 [1315896] Ann N Y Acad Sci. 1992 Jun 28;654:400-15 [1632593] Eur J Pharmacol. 1992 Apr 22;214(2-3):273-6 [1325358] Eur J Pharmacol. 1992 Jun 5;216(2):157-66 [1327810] Eur J Pharmacol. 1992 Jul 21;218(1):195-6 [1327826] J Pharmacol Exp Ther. 1992 Oct;263(1):147-52 [1328602] Br J Pharmacol. 1992 Oct;107(2):573-6 [1330187] Neurosci Lett. 1993 Apr 30;153(2):232-6 [8392157] Peptides. 1993 Sep-Oct;14(5):893-907 [8284266] NIDA Res Monogr. 1993;135:71-91 [8289905] Jpn J Pharmacol. 1994 Sep;66(1):131-7 [7861658] Eur J Pharmacol. 1995 Jun 23;280(1):55-61 [7498254] Annu Rev Pharmacol Toxicol. 1996;36:379-401 [8725395] Brain Res Bull. 1996;39(3):185-8 [8866695] Eur J Pharmacol. 1996 Mar 28;299(1-3):33-9 [8901005] Brain Res. 1997 Jan 9;744(2):327-34 [9027392] J Pharmacol Exp Ther. 1997 Mar;280(3):1423-31 [9067332] Eur J Pharmacol. 1998 Mar 12;345(1):27-34 [9593590] Prog Neurobiol. 1998 Dec;56(6):613-72 [9871940] Nature. 1999 Jun 17;399(6737):697-700 [10385123] Pharmacol Biochem Behav. 2005 Mar;80(3):471-9 [15740790] J Biol Chem. 2005 Mar 25;280(12):11152-64 [15657030] Mol Pharmacol. 2005 Oct;68(4):1079-86 [16006595] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19208-13 [16365317] Mol Pharmacol. 2006 Apr;69(4):1137-45 [16399848] Trends Pharmacol Sci. 2007 Jan;28(1):23-31 [17150262] Eur J Pharmacol. 2007 Jul 2;566(1-3):75-82 [17383633] Neuropsychopharmacology. 2009 Mar;34(4):887-98 [18704097] Neuron. 1999 Sep;24(1):243-52 [10677041] J Biol Chem. 2000 Aug 25;275(34):26128-35 [10842167] J Neurosci. 2000 Nov 15;20(22):RC110 [11069979] Psychopharmacology (Berl). 2000 Dec;153(1):31-43 [11255927] J Pharmacol Exp Ther. 2001 Sep;298(3):1193-8 [11504820] J Neurosci. 2001 Oct 1;21(19):7598-607 [11567050] J Pharmacol Exp Ther. 2002 Nov;303(2):723-9 [12388657] Eur J Pharmacol. 2003 Apr 25;467(1-3):233-4 [12706480] Eur J Neurosci. 2003 Oct;18(7):1915-22 [14622224] Eur J Pharmacol. 1988 Jan 27;146(1):185-6 [2832195] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biopsych.2008.09.009 ER - TY - JOUR T1 - Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist. AN - 66777120; 18996507 AB - A high rate of comorbidity exists between mood disorders and alcohol dependence. Furthermore, both ketamine, a dissociative anesthetic with a recently described rapid-onset antidepressant effect, and ethanol are N-methyl-D-aspartate (NMDA) receptor antagonists. Previous investigations of healthy individuals with a family history of alcohol dependence have found that these individuals have an attenuated response to ketamine's perceptual disturbance and dysphoric effects similar to that found in individuals with a self-reported history of alcohol dependence. This study investigated whether a family history of alcohol dependence influences ketamine's initial antidepressant effect. Twenty-six subjects with DSM-IV treatment-resistant major depression were given an open-label intravenous infusion of ketamine hydrochloride (.5 mg/kg) and rated using various depression scales at baseline, 40, 80, 120, and 230 min postinfusion. The primary outcome measure was Montgomery-Asberg Depression Rating Scale (MADRS) scores. Subjects with a family history of alcohol dependence showed significantly greater improvement in MADRS scores compared with subjects who had no family history of alcohol dependence. A family history of alcohol dependence appears to predict a rapid initial antidepressant response to an NMDA receptor antagonist. JF - Biological psychiatry AU - Phelps, Laura E AU - Brutsche, Nancy AU - Moral, Jazmin R AU - Luckenbaugh, David A AU - Manji, Husseini K AU - Zarate, Carlos A AD - Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health/DHHS, 10 Center Drive, Bethesda, MD 20892-1282, USA. Y1 - 2009/01/15/ PY - 2009 DA - 2009 Jan 15 SP - 181 EP - 184 VL - 65 IS - 2 KW - Antidepressive Agents KW - 0 KW - Excitatory Amino Acid Antagonists KW - Receptors, N-Methyl-D-Aspartate KW - Ketamine KW - 690G0D6V8H KW - Index Medicus KW - Pedigree KW - Young Adult KW - Humans KW - Linear Models KW - Aged KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Psychiatric Status Rating Scales KW - Adult KW - Treatment Outcome KW - Family KW - Middle Aged KW - Genetic Predisposition to Disease KW - Adolescent KW - Time Factors KW - Family Health KW - Female KW - Male KW - Depressive Disorder, Major -- drug therapy KW - Antidepressive Agents -- pharmacology KW - Depressive Disorder, Major -- metabolism KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Alcoholism -- genetics KW - Receptors, N-Methyl-D-Aspartate -- genetics KW - Depressive Disorder, Major -- genetics KW - Ketamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66777120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Family+history+of+alcohol+dependence+and+initial+antidepressant+response+to+an+N-methyl-D-aspartate+antagonist.&rft.au=Phelps%2C+Laura+E%3BBrutsche%2C+Nancy%3BMoral%2C+Jazmin+R%3BLuckenbaugh%2C+David+A%3BManji%2C+Husseini+K%3BZarate%2C+Carlos+A&rft.aulast=Phelps&rft.aufirst=Laura&rft.date=2009-01-15&rft.volume=65&rft.issue=2&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/10.1016%2Fj.biopsych.2008.09.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2008-12-30 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00088699; ClinicalTrials.gov N1 - SuppNotes - Cited By: Biol Psychiatry. 2000 Feb 15;47(4):351-4 [10686270] Arch Gen Psychiatry. 2008 Jul;65(7):826-38 [18606955] Ann Intern Med. 2002 Oct 15;137(8):693-5 [12379071] Ann N Y Acad Sci. 2003 Nov;1003:176-84 [14684445] Ann N Y Acad Sci. 2003 Nov;1003:292-308 [14684453] Anesth Analg. 2004 Oct;99(4):1136-40, table of contents [15385364] Am J Psychiatry. 2004 Oct;161(10):1776-82 [15465973] Mod Probl Pharmacopsychiatry. 1974;7(0):151-69 [4412100] Br J Psychiatry. 1979 Apr;134:382-9 [444788] Am J Psychiatry. 1995 Mar;152(3):332-40 [7864257] J Trauma Stress. 1998 Jan;11(1):125-36 [9479681] J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 [14399272] Am J Addict. 2006 Jul-Aug;15(4):278-85 [16867922] Br J Psychiatry. 2006 Aug;189:173-9 [16880489] Arch Gen Psychiatry. 2006 Aug;63(8):856-64 [16894061] Psychopharmacology (Berl). 2006 Sep;187(4):455-66 [16835771] J Clin Psychiatry. 2007 Dec;68(12):1931-8 [18162025] Biol Psychiatry. 2008 Feb 15;63(4):349-52 [17643398] Compr Psychiatry. 2001 Mar-Apr;42(2):87-95 [11244143] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.biopsych.2008.09.029 ER - TY - JOUR T1 - A novel side-bridged hybrid phosphonate/acetate pendant cyclam: Synthesis, characterization, and Cu small animal PET imaging AN - 20342474; 9012044 AB - Copper-64 (t1/2 = 12.7 h; beta +: 0.653 MeV, 17.4%; beta -: 0.578 MeV, 39%) is produced in a biomedical cyclotron and has applications in both imaging and therapy. Macrocyclic chelators are widely used as bifunctional chelators to bind copper radionuclides to antibodies and peptides owing to their relatively high kinetic stability. A novel side-bridged cyclam featuring both pendant acetate and phosphonate groups was synthesized using a Kabachnik-Fields approach followed by hydrobromic acid deprotection. The Cu(II) complex of the novel ligand was synthesized, radiolabeling with 64Cu was demonstrated, and in vitro (serum) stability was performed. In addition, in vivo distribution and clearance of the 64Cu-labeled complex was visualized by positron emission tomography (PET) imaging. This novel chelate may be useful in 64Cu-mediated diagnostic positron emission tomography (PET) imaging as well as targeted radiotherapeutic applications. JF - Bioorganic and Medicinal Chemistry AU - Boswell, C Andrew AU - Regino, Celeste A S AU - Baidoo, Kwamena E AU - Wong, Karen J AU - Milenic, Diane E AU - Kelley, James A AU - Lai, Christopher C AU - Brechbiel, Martin W AD - Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 Center Drive, Bethesda, MA 20892-1088, United States, martinwb@mail.nih.gov Y1 - 2009/01/15/ PY - 2009 DA - 2009 Jan 15 SP - 548 EP - 552 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 2 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Positron emission tomography KW - Copper-64 KW - Side-bridged cyclam KW - Bifunctional chelating agent KW - Antibodies KW - phosphonates KW - Kinetics KW - Hybrids KW - Radioisotopes KW - Copper KW - Chelating agents KW - Chelates KW - Acetic acid KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20342474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Greener+management+international&rft.atitle=Stalking+sustainability&rft.au=Zadek%2C+Simon&rft.aulast=Zadek&rft.aufirst=Simon&rft.date=1999-07-01&rft.volume=26&rft.issue=&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Greener+management+international&rft.issn=09669671&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Antibodies; phosphonates; Hybrids; Kinetics; Radioisotopes; Positron emission tomography; Copper; Chelates; Chelating agents; Acetic acid DO - http://dx.doi.org/10.1016/j.bmc.2008.11.073 ER - TY - JOUR T1 - Treating drug abuse and addiction in the criminal justice system: improving public health and safety. AN - 66821089; 19141766 AB - Despite increasing evidence that addiction is a treatable disease of the brain, most individuals do not receive treatment. Involvement in the criminal justice system often results from illegal drug-seeking behavior and participation in illegal activities that reflect, in part, disrupted behavior ensuing from brain changes triggered by repeated drug use. Treating drug-involved offenders provides a unique opportunity to decrease substance abuse and reduce associated criminal behavior. Emerging neuroscience has the potential to transform traditional sanction-oriented public safety approaches by providing new therapeutic strategies against addiction that could be used in the criminal justice system. We summarize relevant neuroscientific findings and evidence-based principles of addiction treatment that, if implemented in the criminal justice system, could help improve public heath and reduce criminal behavior. JF - JAMA AU - Chandler, Redonna K AU - Fletcher, Bennett W AU - Volkow, Nora D AD - Services Research Branch, National Institute on Drug Abuse, Bethesda, MD 20892, USA. Y1 - 2009/01/14/ PY - 2009 DA - 2009 Jan 14 SP - 183 EP - 190 VL - 301 IS - 2 KW - Abridged Index Medicus KW - Index Medicus KW - Public Health KW - Crime KW - Humans KW - Mental Health Services KW - United States -- epidemiology KW - Brain -- physiology KW - Health Services Accessibility KW - Substance-Related Disorders -- therapy KW - Prisons -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66821089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Treating+drug+abuse+and+addiction+in+the+criminal+justice+system%3A+improving+public+health+and+safety.&rft.au=Chandler%2C+Redonna+K%3BFletcher%2C+Bennett+W%3BVolkow%2C+Nora+D&rft.aulast=Chandler&rft.aufirst=Redonna&rft.date=2009-01-14&rft.volume=301&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/10.1001%2Fjama.2008.976 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2009-01-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Ann N Y Acad Sci. 2007 Dec;1121:639-55 [17846162] Ann N Y Acad Sci. 2007 Dec;1121:421-30 [17846161] Addiction. 2008 Aug;103(8):1333-42 [18855822] Drug Alcohol Depend. 1999 Dec 1;57(2):167-74 [10617100] J Urban Health. 2001 Jun;78(2):214-35 [11419576] J Urban Health. 2001 Jun;78(2):241-55 [11419578] J Urban Health. 2001 Jun;78(2):279-89 [11419581] Nature. 2001 Jul 12;412(6843):141-2 [11449260] Psychopharmacology (Berl). 2002 Feb;159(4):351-60 [11823887] Drug Alcohol Depend. 2002 Jun 1;67(1):53-72 [12062779] AIDS Educ Prev. 2002 Oct;14(5 Suppl B):45-52 [12413192] Ann Intern Med. 2003 Feb 4;138(3):187-90 [12558357] J Clin Invest. 2003 May;111(10):1444-51 [12750391] Arch Gen Psychiatry. 2004 Mar;61(3):223-9 [14993109] J Subst Abuse Treat. 2004 Apr;26(3):151-8; discussion 159-65 [15063905] Clin Infect Dis. 2004 Jun 15;38(12):1754-60 [15227623] Behav Sci Law. 2004;22(4):431-48 [15282833] Neuropharmacology. 2004;47 Suppl 1:140-7 [15464133] Am Psychol. 1991 Oct;46(10):1036-45 [1746771] Exp Clin Psychopharmacol. 1997 Aug;5(3):256-62 [9260073] Science. 1997 Oct 3;278(5335):52-8 [9311926] Am J Psychiatry. 1998 Jun;155(6):711-3 [9619141] J Nerv Ment Dis. 1998 Dec;186(12):737-45 [9865811] J Neurosci. 2004 Dec 8;24(49):11017-22 [15590917] Clin Infect Dis. 2005 Apr 15;40 Suppl 5:S367-72 [15768350] Am J Psychiatry. 2005 Aug;162(8):1403-13 [16055761] J Urban Health. 2005 Sep;82(3):411-9 [15917502] Pharmacol Ther. 2005 Oct;108(1):3-17 [16098597] J Addict Dis. 2005;24(3):49-59 [16186082] Health Econ. 2005 Nov;14(11):1133-50 [15880389] AIDS. 2005 Oct;19 Suppl 3:S41-6 [16251827] Nat Neurosci. 2005 Nov;8(11):1429-30 [16251981] Nat Neurosci. 2005 Nov;8(11):1431-6 [16251982] Nat Neurosci. 2005 Nov;8(11):1437-9 [16251983] Nat Neurosci. 2005 Nov;8(11):1442-4 [16251985] Nat Neurosci. 2005 Nov;8(11):1481-9 [16251991] Subst Use Misuse. 2005;40(13-14):1983-99, 2043-8 [16282089] Arch Gen Psychiatry. 2006 Feb;63(2):210-8 [16461865] Epidemiol Infect. 2006 Apr;134(2):243-8 [16490126] J Neurosci. 2006 Jun 14;26(24):6583-8 [16775146] Trends Mol Med. 2006 Dec;12(12):559-66 [17070107] N Engl J Med. 2007 Jan 11;356(2):157-65 [17215533] Public Health Rep. 2007 Jan-Feb;122(1):49-54 [17236608] Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12;363(1507):3245-55 [18640924] Aust N Z J Psychiatry. 2007 Dec;41(12):957-68 [17999268] Science. 2007 Jan 26;315(5811):531-4 [17255515] JAMA. 2007 Feb 21;297(7):737-40 [17312293] J Subst Abuse Treat. 2007 Apr;32(3):239-54 [17383549] Neuron. 2007 Apr 19;54(2):183-6 [17442239] Drug Alcohol Depend. 2007 Sep;90 Suppl 1:S85-91 [17101239] Neuropsychol Rev. 2007 Sep;17(3):317-36 [17690986] JAMA. 2007 Oct 10;298(14):1641-51 [17925516] Drug Alcohol Depend. 2007 Dec 1;91(2-3):220-7 [17628351] Comment In: JAMA. 2009 May 13;301(18):1881; author reply 1881-2 [19436014] Erratum In: JAMA. 2009 Mar 11;301(10):1024 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1001/jama.2008.976 ER - TY - JOUR T1 - Nonsmoking and other cofactors for Kaposi's sarcoma AN - 20340416; 9008179 AB - The recent series of 28 cases of HIV-negative Kaposi's sarcoma in homo /bisexual men reported by Lanternier et al., as well as the subsequent editorial comment by Colman and Blackbourn, highlights the strong contribution of cofactors to the development of this malignancy. The primary cause of Kaposi's sarcoma is infection with Kaposi's sarcoma associated herpesvirus (KSHV, also known as human herpesvirus 8), but the vast majority of KSHV-infected people do not develop Kaposi's sarcoma. We estimated that the annual incidence of classic Kaposi's sarcoma (cKS) is about 30/100 000 KSHV-seropositive Mediterranean men over 50 years of age, or approximately 0.3% over 10 years. In contrast, the annual incidence of AIDS Kaposi's sarcoma was about 3/100 in untreated HIV-infected KSHV-seropositive homosexual men, or about 30% over 10 years. This illustrates that HIV is a very potent cofactor, increasing the risk of Kaposi's sarcoma by approximately 100-fold. JF - AIDS AU - Goeder, J J AD - Infections & Immunoepidemiology Branch, National Cancer Institute, Rockville, MD 20852, USA, goedertj@mail.nih.gov Y1 - 2009/01/14/ PY - 2009 DA - 2009 Jan 14 SP - 273 EP - 278 VL - 23 IS - 2 SN - 0269-9370, 0269-9370 KW - Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Age KW - Human herpesvirus 8 KW - Kaposi's sarcoma-associated herpesvirus KW - homosexuality KW - bisexuality KW - Infection KW - Malignancy KW - Cofactors KW - Kaposi's sarcoma KW - Human immunodeficiency virus KW - MED KW - Bisexual KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20340416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Nonsmoking+and+other+cofactors+for+Kaposi%27s+sarcoma&rft.au=Goeder%2C+J+J&rft.aulast=Goeder&rft.aufirst=J&rft.date=2009-01-14&rft.volume=23&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e32831f4674 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Acquired immune deficiency syndrome; Malignancy; Cofactors; Kaposi's sarcoma; Bisexual; Infection; homosexuality; bisexuality; Human immunodeficiency virus; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus; MED DO - http://dx.doi.org/10.1097/QAD.0b013e32831f4674 ER - TY - JOUR T1 - Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: a randomized controlled trial AN - 20326747; 9008169 AB - Objective: To evaluate whether interleukin (IL)-2 in patients with chronic HIV infection can maintain CD4 T cell counts during 6 months of HAART interruption. Design: Prospective, randomized, controlled, open-label phase II noninferiority trial comparing IL-2 with HAART interruption or continuous HAART. Methods: Forty-one IL-2-experienced (three or more prior cycles) HIV-1-infected adults with CD4 cell count at least 500 cells/kl were randomized in the ratio 2: 1 to interrupted (I = 27) or continuous (C= 14) HAART for 6 months following an initial IL-2 cycle. Subsequent IL-2 cycles were triggered by CD4 T cell counts less than 90% of baseline. Immune, metabolic, and quality of life indices were compared (Mann-Whitney and Fisher's exact tests), defining noninferiority as a percentage difference (C-I) in treatment success (CD4 T cells .90% of baseline at 6 months) with a 95% confidence interval (CI) lower limit greater than -20%. Results: Demographic and immune parameters were similar between the groups at baseline. Median CD4 T cell count, HIV viral load, and treatment success differed significantly at 6 months (I: 866 cellskl, 39 389 copies/ml, 48.1%; C: 1246 cells/kl, C). Following HAART interruption, single cases of acute retroviral syndrome, secondary syphilis, non-Hodgkin's lym-phoma, and Kaposi's sarcoma recurrence were observed. Conclusion: IL-2 alone was inferior to IL-2 with HAART in maintaining baseline CD4 T cell counts. HAART interruption had a small impact on metabolic parameters and quality of life. JF - AIDS AU - Porter, BO AU - Anthony, K B AU - Shen, J AU - Hahn, B AU - Keh, CE AU - Maldarelli, F AU - Blackwelder, W C AU - Lane, H C AU - Kovacs, JA AU - Davey, R T AU - Sereti, I AD - National Institutes of Health, Building 10-Magnuson Clinical Center, Room 11C103, 10 Center Drive, Bethesda, MD 20982, USA, isereti@niaid.nih.gov Y1 - 2009/01/14/ PY - 2009 DA - 2009 Jan 14 SP - 203 EP - 212 VL - 23 IS - 2 SN - 0269-9370, 0269-9370 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Interleukin 2 KW - Statistical analysis KW - Clinical trials KW - Demography KW - CD4 antigen KW - Kaposi's sarcoma KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - Energy KW - Treponema pallidum KW - Chronic infection KW - Lymphocytes T KW - Syphilis KW - Quality of life KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20326747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Inferiority+of+IL-2+alone+versus+IL-2+with+HAART+in+maintaining+CD4+T+cell+counts+during+HAART+interruption%3A+a+randomized+controlled+trial&rft.au=Porter%2C+BO%3BAnthony%2C+K+B%3BShen%2C+J%3BHahn%2C+B%3BKeh%2C+CE%3BMaldarelli%2C+F%3BBlackwelder%2C+W+C%3BLane%2C+H+C%3BKovacs%2C+JA%3BDavey%2C+R+T%3BSereti%2C+I&rft.aulast=Porter&rft.aufirst=BO&rft.date=2009-01-14&rft.volume=23&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e32831cc114 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Demography; CD4 antigen; Kaposi's sarcoma; Interleukin 2; highly active antiretroviral therapy; Energy; Chronic infection; Statistical analysis; Lymphocytes T; Syphilis; Clinical trials; Quality of life; Human immunodeficiency virus; Treponema pallidum DO - http://dx.doi.org/10.1097/QAD.0b013e32831cc114 ER - TY - JOUR T1 - Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study. AN - 66816610; 19139364 AB - To determine whether menopausal hormone therapy (HT) affects regional brain volumes, including hippocampal and frontal regions. Brain MRI scans were obtained in a subset of 1,403 women aged 71-89 years who participated in the Women's Health Initiative Memory Study (WHIMS). WHIMS was an ancillary study to the Women's Health Initiative, which consisted of two randomized, placebo-controlled trials: 0.625 mg conjugated equine estrogens (CEE) with or without 2.5 mg medroxyprogesterone acetate (MPA) in one daily tablet. Scans were performed, on average, 3.0 years post-trial for the CEE + MPA trial and 1.4 years post-trial for the CEE-Alone trial; average on-trial follow-up intervals were 4.0 years for CEE + MPA and 5.6 years for CEE-Alone. Total brain, ventricular, hippocampal, and frontal lobe volumes, adjusted for age, clinic site, estimated intracranial volume, and dementia risk factors, were the main outcome variables. Compared with placebo, covariate-adjusted mean frontal lobe volume was 2.37 cm(3) lower among women assigned to HT (p = 0.004), mean hippocampal volume was slightly (0.10 cm(3)) lower (p = 0.05), and differences in total brain volume approached significance (p = 0.07). Results were similar for CEE + MPA and CEE-Alone. HT-associated reductions in hippocampal volumes were greatest in women with the lowest baseline Modified Mini-Mental State Examination scores (scores <90). Conjugated equine estrogens with or without MPA are associated with greater brain atrophy among women aged 65 years and older; however, the adverse effects are most evident in women experiencing cognitive deficits before initiating hormone therapy. JF - Neurology AU - Resnick, S M AU - Espeland, M A AU - Jaramillo, S A AU - Hirsch, C AU - Stefanick, M L AU - Murray, A M AU - Ockene, J AU - Davatzikos, C AD - Laboratory of Personality and Cognition, Biomedical Research Center/04B317, Baltimore, MD 21224, USA. susan.resnick@nih.gov Y1 - 2009/01/13/ PY - 2009 DA - 2009 Jan 13 SP - 135 EP - 142 VL - 72 IS - 2 KW - Estrogens KW - 0 KW - Estrogens, Conjugated (USP) KW - Abridged Index Medicus KW - Index Medicus KW - Magnetic Resonance Imaging KW - Causality KW - Age Factors KW - Humans KW - Prefrontal Cortex -- physiopathology KW - Aged KW - Atrophy -- physiopathology KW - Cognition Disorders -- chemically induced KW - Dementia -- chemically induced KW - Prefrontal Cortex -- drug effects KW - Atrophy -- pathology KW - Hippocampus -- drug effects KW - Atrophy -- chemically induced KW - Dementia -- pathology KW - Prefrontal Cortex -- pathology KW - Hippocampus -- physiopathology KW - Dementia -- physiopathology KW - Hippocampus -- pathology KW - Cognition Disorders -- pathology KW - Neuropsychological Tests KW - Estrogens -- adverse effects KW - Cognition Disorders -- physiopathology KW - Female KW - Brain -- physiopathology KW - Estrogen Replacement Therapy -- adverse effects KW - Brain -- pathology KW - Brain -- drug effects KW - Estrogens, Conjugated (USP) -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66816610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Postmenopausal+hormone+therapy+and+regional+brain+volumes%3A+the+WHIMS-MRI+Study.&rft.au=Resnick%2C+S+M%3BEspeland%2C+M+A%3BJaramillo%2C+S+A%3BHirsch%2C+C%3BStefanick%2C+M+L%3BMurray%2C+A+M%3BOckene%2C+J%3BDavatzikos%2C+C&rft.aulast=Resnick&rft.aufirst=S&rft.date=2009-01-13&rft.volume=72&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/10.1212%2F01.wnl.0000339037.76336.cf LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: BMC Neurosci. 2006;7:24 [16533397] Neuroreport. 2006 Jan 23;17(1):101-4 [16361959] Menopause. 2006 Jul-Aug;13(4):584-91 [16837880] Psychiatry Res. 2006 Oct 30;147(2-3):127-34 [16935478] Endocr Rev. 2006 Oct;27(6):575-605 [16763155] Endocrinology. 2006 Nov;147(11):5303-13 [16916950] Neurology. 2006 Oct 24;67(8):1363-9 [17060561] Acad Radiol. 2007 May;14(5):603-12 [17434074] Neurology. 2007 Sep 25;69(13):1322-30 [17893293] Neurobiol Aging. 2008 Jan;29(1):95-101 [17030472] Eur J Pharmacol. 2008 May 6;585(1):163-75 [18423446] Neurology. 2009 Jan 13;72(2):125-34 [19139363] J Clin Endocrinol Metab. 2006 May;91(5):1802-10 [16522699] Neuroscience. 2000;95(3):721-5 [10670438] JAMA. 2000 Jul 19;284(3):307-8 [10891957] Cephalalgia. 2000 Apr;20(3):200-7 [10997774] Neurology. 2000 Sep 26;55(6):875-7 [10994014] Psychiatry Res. 2001 Jul 1;107(1):11-8 [11472860] Neuroimage. 2002 Feb;15(2):422-34 [11798276] JAMA. 2002 Jul 17;288(3):321-33 [12117397] IEEE Trans Med Imaging. 2002 Nov;21(11):1421-39 [12575879] Neurology. 2003 Apr 8;60(7):1082-8 [12682310] JAMA. 2003 May 28;289(20):2651-62 [12771112] JAMA. 2003 May 28;289(20):2663-72 [12771113] JAMA. 2003 May 28;289(20):2673-84 [12771114] Neurobiol Aging. 2003 Sep;24(5):725-32 [12885580] Neuroimage. 2004 Jan;21(1):364-71 [14741674] JAMA. 2004 Apr 14;291(14):1701-12 [15082697] JAMA. 2004 Jun 23;291(24):2947-58 [15213206] JAMA. 2004 Jun 23;291(24):2959-68 [15213207] J Clin Psychiatry. 1987 Aug;48(8):314-8 [3611032] J Comput Assist Tomogr. 1998 Sep-Oct;22(5):827-37 [9754125] Horm Behav. 1998 Oct;34(2):171-82 [9799627] Control Clin Trials. 1998 Dec;19(6):604-21 [9875839] JAMA. 1999 Apr 7;281(13):1197-202 [10199429] Neurology. 1999 Jul 13;53(1):189-96 [10408558] Endocr Rev. 2005 May;26(3):308-12 [15851820] Neurobiol Aging. 2005 Aug-Sep;26(8):1205-13 [15917105] Neurology. 2005 Oct 25;65(8):1227-31 [16247049] Comment In: Neurology. 2009 Nov 3;73(18):1514 [19884585] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1212/01.wnl.0000339037.76336.cf ER - TY - CPAPER T1 - Modulation of Foxp3+ Regulatory T Cells by Microbes T2 - 2009 Keystone Symposia on Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) AN - 41911311; 5114590 JF - 2009 Keystone Symposia on Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6) AU - Belkaid, Yasmine Y1 - 2009/01/13/ PY - 2009 DA - 2009 Jan 13 KW - Lymphocytes T KW - Immunoregulation KW - Foxp3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Innate%2C+Adaptive+and+Regulatory+Immune+Responses+to+Intestinal+Microbiota+%28A6%29&rft.atitle=Modulation+of+Foxp3%2B+Regulatory+T+Cells+by+Microbes&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2009-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Innate%2C+Adaptive+and+Regulatory+Immune+Responses+to+Intestinal+Microbiota+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Introduction to Biomedical Natural Language Processing T2 - Seventh Asia Pacific Bioinformatics Conference (APBC 2009) AN - 41770370; 5021875 JF - Seventh Asia Pacific Bioinformatics Conference (APBC 2009) AU - Lu, Zhiyong AU - Cohen, Kevin Y1 - 2009/01/13/ PY - 2009 DA - 2009 Jan 13 KW - Language KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41770370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventh+Asia+Pacific+Bioinformatics+Conference+%28APBC+2009%29&rft.atitle=An+Introduction+to+Biomedical+Natural+Language+Processing&rft.au=Lu%2C+Zhiyong%3BCohen%2C+Kevin&rft.aulast=Lu&rft.aufirst=Zhiyong&rft.date=2009-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventh+Asia+Pacific+Bioinformatics+Conference+%28APBC+2009%29&rft.issn=&rft_id=info:doi/ L2 - http://bioinfo.au.tsinghua.edu.cn/apbc2009/?Program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Affinity T Cell Receptor Gene Therapy Breaks Tolerance and Elicits Autoimmunity and Cancer Regression T2 - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AN - 41927282; 5114716 JF - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AU - Johnson, Laura Y1 - 2009/01/11/ PY - 2009 DA - 2009 Jan 11 KW - Cancer KW - T-cell receptor KW - Immunological tolerance KW - Gene therapy KW - Autoimmunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41927282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.atitle=High+Affinity+T+Cell+Receptor+Gene+Therapy+Breaks+Tolerance+and+Elicits+Autoimmunity+and+Cancer+Regression&rft.au=Johnson%2C+Laura&rft.aulast=Johnson&rft.aufirst=Laura&rft.date=2009-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Health & Human Services, National Institutes of Health, USA T2 - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AN - 41925520; 5114700 JF - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AU - Dudley, Mark Y1 - 2009/01/11/ PY - 2009 DA - 2009 Jan 11 KW - USA KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41925520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.atitle=Health+%26amp%3B+Human+Services%2C+National+Institutes+of+Health%2C+USA&rft.au=Dudley%2C+Mark&rft.aulast=Dudley&rft.aufirst=Mark&rft.date=2009-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor Specific CD4 Cells, but not CD8 Cells, Induce Phenotypic and Functional Changes on Tumor Associated Macrophages T2 - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AN - 41924742; 5114693 JF - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AU - Perez-Diez, Ainhoa Y1 - 2009/01/11/ PY - 2009 DA - 2009 Jan 11 KW - Tumors KW - CD8 antigen KW - CD4 antigen KW - Macrophages KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41924742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.atitle=Tumor+Specific+CD4+Cells%2C+but+not+CD8+Cells%2C+Induce+Phenotypic+and+Functional+Changes+on+Tumor+Associated+Macrophages&rft.au=Perez-Diez%2C+Ainhoa&rft.aulast=Perez-Diez&rft.aufirst=Ainhoa&rft.date=2009-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhancing the Power of Tumor-Specific T Cells T2 - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AN - 41916076; 5114702 JF - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AU - Restifo, Nicholas Y1 - 2009/01/11/ PY - 2009 DA - 2009 Jan 11 KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41916076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.atitle=Enhancing+the+Power+of+Tumor-Specific+T+Cells&rft.au=Restifo%2C+Nicholas&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2009-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Innate Resistance, Inflammation, and Cancer T2 - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AN - 41916044; 5114694 JF - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AU - Trinchieri, Giorgio Y1 - 2009/01/11/ PY - 2009 DA - 2009 Jan 11 KW - Cancer KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41916044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.atitle=Innate+Resistance%2C+Inflammation%2C+and+Cancer&rft.au=Trinchieri%2C+Giorgio&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2009-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of NKT Cell Subsets in the Regulation of Anti-Tumor Immunity T2 - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AN - 41911992; 5114699 JF - 2009 Keystone Symposia on Mobilizing Cellular Immunity for Cancer Therapy (A3) AU - Berzofsky, Jay Y1 - 2009/01/11/ PY - 2009 DA - 2009 Jan 11 KW - Immunity KW - Lymphocytes T KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.atitle=Role+of+NKT+Cell+Subsets+in+the+Regulation+of+Anti-Tumor+Immunity&rft.au=Berzofsky%2C+Jay&rft.aulast=Berzofsky&rft.aufirst=Jay&rft.date=2009-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Mobilizing+Cellular+Immunity+for+Cancer+Therapy+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=98 1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss of SUMO-1 in Mice is not Lethal Due to Compensation by SUMO-2/3 T2 - 2009 Keystone Symposia on the Many Faces of Ubiquitin (A4) AN - 41899114; 5113198 JF - 2009 Keystone Symposia on the Many Faces of Ubiquitin (A4) AU - Kuehn, Michael Y1 - 2009/01/11/ PY - 2009 DA - 2009 Jan 11 KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+the+Many+Faces+of+Ubiquitin+%28A4%29&rft.atitle=Loss+of+SUMO-1+in+Mice+is+not+Lethal+Due+to+Compensation+by+SUMO-2%2F3&rft.au=Kuehn%2C+Michael&rft.aulast=Kuehn&rft.aufirst=Michael&rft.date=2009-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+the+Many+Faces+of+Ubiquitin+%28A4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=96 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Allosteric Activation of Ubiquitin Ligase Activity by a Novel E2 Binding Region T2 - 2009 Keystone Symposia on the Many Faces of Ubiquitin (A4) AN - 41899072; 5113179 JF - 2009 Keystone Symposia on the Many Faces of Ubiquitin (A4) AU - Byrd, R Y1 - 2009/01/11/ PY - 2009 DA - 2009 Jan 11 KW - Allosteric properties KW - Ubiquitin-protein ligase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+the+Many+Faces+of+Ubiquitin+%28A4%29&rft.atitle=Allosteric+Activation+of+Ubiquitin+Ligase+Activity+by+a+Novel+E2+Binding+Region&rft.au=Byrd%2C+R&rft.aulast=Byrd&rft.aufirst=R&rft.date=2009-01-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+the+Many+Faces+of+Ubiquitin+%28A4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=96 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation AN - 902339543; 14442306 AB - Histone modifications have been implicated in stem cell maintenance and differentiation. We have analyzed genome-wide changes in gene expression and histone modifications during differentiation of multipotent human primary hematopoietic stem cells/progenitor cells (HSCs/HPCs) into erythrocyte precursors. Our data indicate that H3K4me1, H3K9me1, and H3K27me1 associate with enhancers of differentiation genes prior to their activation and correlate with basal expression, suggesting that these monomethylations are involved in the maintenance of activation potential required for differentiation. In addition, although the majority of genes associated with both H3K4me3 and H3K27me3 in HSCs/HPCs become silent and lose H3K4me3 after differentiation, those that lose H3K27me3 and become activated after differentiation are associated with increased levels of H2A.Z, H3K4me1, H3K9me1, H4K20me1, and RNA polymerase II in HSCs/HPCs. Thus, our data suggest that gene expression changes during differentiation are programmed by chromatin modifications present at the HSC/HPC stage and provide a resource for enhancer and promoter identification. JF - Cell Stem Cell AU - Cui, Kairong AU - Zang, Chongzhi AU - Roh, Tae-Young AU - Schones, Dustin E AU - Childs, Richard W AU - Peng, Weiqun AU - Zhao, Keji Y1 - 2009/01/09/ PY - 2009 DA - 2009 Jan 09 SP - 80 EP - 93 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA VL - 4 IS - 1 SN - 1934-5909, 1934-5909 KW - Genetics Abstracts; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - STEMCELL KW - SYSBIO KW - Differentiation KW - Enhancers KW - Promoters KW - Stem cells KW - DNA-directed RNA polymerase KW - Histones KW - Data processing KW - Chromatin KW - Erythrocytes KW - Hemopoiesis KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure KW - F 06910:Microorganisms & Parasites KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902339543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Financial+Post+%28Index-only%29&rft.atitle=%5BBuilding+corporate+accountability%5D&rft.au=Evans%2C+Richard%3BZadek%2C+Simon%3BPruzan%2C+Peter&rft.aulast=Evans&rft.aufirst=Richard&rft.date=1998-02-14&rft.volume=91&rft.issue=7&rft.spage=R9&rft.isbn=&rft.btitle=&rft.title=Financial+Post+%28Index-only%29&rft.issn=08388431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Promoters; Enhancers; Differentiation; DNA-directed RNA polymerase; Stem cells; Data processing; Histones; Chromatin; Erythrocytes; Hemopoiesis DO - http://dx.doi.org/10.1016/j.stem.2008.11.011 ER - TY - JOUR T1 - Characterization of the differential roles of the twin C1a and C1b domains of protein kinase C-delta. AN - 66805717; 19001377 AB - Classic and novel protein kinase C (PKC) isozymes contain two zinc finger motifs, designated "C1a" and "C1b" domains, which constitute the recognition modules for the second messenger diacylglycerol (DAG) or the phorbol esters. However, the individual contributions of these tandem C1 domains to PKC function and, reciprocally, the influence of protein context on their function remain uncertain. In the present study, we prepared PKCdelta constructs in which the individual C1a and C1b domains were deleted, swapped, or substituted for one another to explore these issues. As isolated fragments, both the deltaC1a and deltaC1b domains potently bound phorbol esters, but the binding of [(3)H]phorbol 12,13-dibutyrate ([(3)H]PDBu) by the deltaC1a domain depended much more on the presence of phosphatidylserine than did that of the deltaC1b domain. In intact PKCdelta, the deltaC1b domain played the dominant role in [(3)H]PDBu binding, membrane translocation, and down-regulation. A contribution from the deltaC1a domain was nonetheless evident, as shown by retention of [(3)H]PDBu binding at reduced affinity, by increased [(3)H]PDBu affinity upon expression of a second deltaC1a domain substituting for the deltaC1b domain, and by loss of persistent plasma membrane translocation for PKCdelta expressing only the deltaC1b domain, but its contribution was less than predicted from the activity of the isolated domain. Switching the position of the deltaC1b domain to the normal position of the deltaC1a domain (or vice versa) had no apparent effect on the response to phorbol esters, suggesting that the specific position of the C1 domain within PKCdelta was not the primary determinant of its activity. JF - The Journal of biological chemistry AU - Pu, Yongmei AU - Garfield, Susan H AU - Kedei, Noemi AU - Blumberg, Peter M AD - Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cancer Biology and Genetics, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/01/09/ PY - 2009 DA - 2009 Jan 09 SP - 1302 EP - 1312 VL - 284 IS - 2 SN - 0021-9258, 0021-9258 KW - Ligands KW - 0 KW - Phorbol Esters KW - Protein Kinase C-delta KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Phorbol Esters -- metabolism KW - Humans KW - Amino Acid Sequence KW - Mice KW - Protein Binding KW - Down-Regulation KW - Molecular Sequence Data KW - Mutation -- genetics KW - Zinc Fingers KW - Substrate Specificity KW - Protein Structure, Tertiary KW - Cell Line KW - Protein Transport KW - Cricetinae KW - Protein Kinase C-delta -- metabolism KW - Protein Kinase C-delta -- chemistry KW - Protein Kinase C-delta -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66805717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Characterization+of+the+differential+roles+of+the+twin+C1a+and+C1b+domains+of+protein+kinase+C-delta.&rft.au=Pu%2C+Yongmei%3BGarfield%2C+Susan+H%3BKedei%2C+Noemi%3BBlumberg%2C+Peter+M&rft.aulast=Pu&rft.aufirst=Yongmei&rft.date=2009-01-09&rft.volume=284&rft.issue=2&rft.spage=1302&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M804796200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1994 Jun 24;269(25):17160-5 [8006023] J Biol Chem. 1994 Jan 21;269(3):2118-24 [8294465] Mol Carcinog. 1995 Mar;12(3):166-76 [7893369] Cell. 1995 Jun 16;81(6):917-24 [7781068] J Biol Chem. 1995 Sep 15;270(37):21852-9 [7665608] J Biol Chem. 1996 Mar 1;271(9):4627-31 [8617724] Biochemistry. 1996 Feb 6;35(5):1612-23 [8634293] J Biol Chem. 1996 Aug 2;271(31):18299-301 [8702464] Biochem Soc Trans. 1997 May;25(2):565-71 [9191157] Cancer Res. 1998 Apr 1;58(7):1423-8 [9537243] Science. 1998 May 15;280(5366):1082-6 [9582122] FEBS Lett. 1999 Jul 30;456(1):27-30 [10452523] FASEB J. 1999 Oct;13(13):1658-76 [10506570] Mol Cancer Ther. 2005 Jan;4(1):141-50 [15657361] J Biol Chem. 2005 Jul 22;280(29):27329-38 [15923197] J Cell Biochem. 2006 Feb 15;97(3):474-84 [16288460] Cancer Res. 2006 Jul 15;66(14):7261-9 [16849575] ChemMedChem. 2006 Mar;1(3):307-14 [16892365] Clin Cancer Res. 2006 Sep 15;12(18):5336-45 [17000666] Curr Top Med Chem. 2007;7(4):355-62 [17305577] Nat Rev Cancer. 2007 Apr;7(4):281-94 [17384583] Pharmacol Res. 2007 Jun;55(6):477-86 [17548205] J Med Chem. 2007 Jul 26;50(15):3465-81 [17591763] Curr Opin Nephrol Hypertens. 2007 Sep;16(5):397-402 [17693752] J Biol Chem. 2007 Nov 16;282(46):33776-87 [17893151] J Biol Chem. 2008 Apr 18;283(16):10543-9 [18263588] Curr Drug Targets. 2008 Aug;9(8):614-25 [18691009] Curr Drug Targets. 2008 Aug;9(8):641-52 [18691011] J Biol Chem. 1999 Dec 24;274(52):37233-9 [10601287] Curr Opin Neurobiol. 2000 Jun;10(3):303-11 [10851170] J Biol Chem. 2001 Jun 1;276(22):19580-7 [11278612] Chem Rev. 2001 Aug;101(8):2353-64 [11749377] Apoptosis. 2003 Jan;8(1):19-27 [12510148] Acc Chem Res. 2003 Jun;36(6):434-43 [12809530] Methods Mol Biol. 2003;233:519-37 [12840532] Biochemistry. 2003 Sep 30;42(38):11194-202 [14503869] Curr Cancer Drug Targets. 2004 Mar;4(2):125-46 [15032665] Curr Pharm Des. 2004;10(12):1371-85 [15134488] J Biol Chem. 2004 Jul 9;279(28):29501-12 [15105418] J Biol Chem. 1983 Oct 10;258(19):11442-5 [6311812] J Biol Chem. 1986 Jul 15;261(20):9341-7 [3459728] Proc Natl Acad Sci U S A. 1989 Jul;86(13):4868-71 [2500657] J Biol Chem. 1991 Sep 25;266(27):18330-8 [1917958] Science. 1992 Oct 23;258(5082):607-14 [1411571] J Biol Chem. 1993 May 25;268(15):10709-12 [8496137] Mol Pharmacol. 1994 Nov;46(5):840-50 [7969070] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M804796200 ER - TY - JOUR T1 - Timing of Elective Repeat Cesarean Delivery at Term and Neonatal Outcomes AN - 223916321; 19129525 AB - Background Because of increased rates of respiratory complications, elective cesarean delivery is discouraged before 39 weeks of gestation unless there is evidence of fetal lung maturity. We assessed associations between elective cesarean delivery at term (37 weeks of gestation or longer) but before 39 weeks of gestation and neonatal outcomes. Methods We studied a cohort of consecutive patients undergoing repeat cesarean sections performed at 19 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network from 1999 through 2002. Women with viable singleton pregnancies delivered electively (i.e., before the onset of labor and without any recognized indications for delivery before 39 weeks of gestation) were included. The primary outcome was the composite of neonatal death and any of several adverse events, including respiratory complications, treated hypoglycemia, newborn sepsis, and admission to the neonatal intensive care unit (ICU). Results Of 24,077 repeat cesarean deliveries at term, 13,258 were performed electively; of these, 35.8% were performed before 39 completed weeks of gestation (6.3% at 37 weeks and 29.5% at 38 weeks) and 49.1% at 39 weeks of gestation. One neonatal death occurred. As compared with births at 39 weeks, births at 37 weeks and at 38 weeks were associated with an increased risk of the primary outcome (adjusted odds ratio for births at 37 weeks, 2.1; 95% confidence interval [CI], 1.7 to 2.5; adjusted odds ratio for births at 38 weeks, 1.5; 95% CI, 1.3 to 1.7; P for trend <0.001). The rates of adverse respiratory outcomes, mechanical ventilation, newborn sepsis, hypoglycemia, admission to the neonatal ICU, and hospitalization for 5 days or more were increased by a factor of 1.8 to 4.2 for births at 37 weeks and 1.3 to 2.1 for births at 38 weeks. Conclusions Elective repeat cesarean delivery before 39 weeks of gestation is common and is associated with respiratory and other adverse neonatal outcomes. JF - The New England Journal of Medicine AU - Tita, Alan TN, MD, PhD AU - Landon, Mark B, MD AU - Spong, Catherine Y, MD AU - Lai, Yinglei, PhD AU - Leveno, Kenneth J, MD AU - Varner, Michael W, MD AU - Moawad, Atef H, MD AU - Caritis, Steve N, MD AU - Meis, Paul J, MD AU - Wapner, Ronald J, MD AU - Sorokin, Yoram, MD AU - Miodovnik, Menachem, MD AU - Carpenter, Marshall, MD AU - Peaceman, Alan M, MD AU - O'Sullivan, Mary J, MD AU - Sibai, Baha M, MD AU - Langer, Oded, MD AU - Thorp, John M, MD AU - Ramin, Susan M, MD AU - Mercer, Brian M, MD Y1 - 2009/01/08/ PY - 2009 DA - 2009 Jan 08 SP - 111 EP - 20 CY - Boston PB - Massachusetts Medical Society VL - 360 IS - 2 SN - 00284793 KW - Medical Sciences KW - Obstetrics KW - Cesarean section KW - Premature birth KW - Clinical outcomes KW - Neonatal care KW - Infant mortality KW - United States KW - Young Adult KW - Infant, Newborn, Diseases -- epidemiology KW - Respiration, Artificial -- statistics & numerical data KW - Humans KW - Continental Population Groups KW - Infant, Newborn KW - Respiratory Distress Syndrome, Newborn -- epidemiology KW - Hypoglycemia -- epidemiology KW - Pregnancy KW - Hospitalization KW - Sepsis -- epidemiology KW - Length of Stay KW - Maternal Age KW - Adult KW - Cohort Studies KW - Adolescent KW - Female KW - Infant, Small for Gestational Age KW - Cesarean Section, Repeat -- adverse effects KW - Infant, Newborn, Diseases -- etiology KW - Surgical Procedures, Elective -- adverse effects KW - Gestational Age KW - Pregnancy Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223916321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Timing+of+Elective+Repeat+Cesarean+Delivery+at+Term+and+Neonatal+Outcomes&rft.au=Tita%2C+Alan+TN%2C+MD%2C+PhD%3BLandon%2C+Mark+B%2C+MD%3BSpong%2C+Catherine+Y%2C+MD%3BLai%2C+Yinglei%2C+PhD%3BLeveno%2C+Kenneth+J%2C+MD%3BVarner%2C+Michael+W%2C+MD%3BMoawad%2C+Atef+H%2C+MD%3BCaritis%2C+Steve+N%2C+MD%3BMeis%2C+Paul+J%2C+MD%3BWapner%2C+Ronald+J%2C+MD%3BSorokin%2C+Yoram%2C+MD%3BMiodovnik%2C+Menachem%2C+MD%3BCarpenter%2C+Marshall%2C+MD%3BPeaceman%2C+Alan+M%2C+MD%3BO%27Sullivan%2C+Mary+J%2C+MD%3BSibai%2C+Baha+M%2C+MD%3BLanger%2C+Oded%2C+MD%3BThorp%2C+John+M%2C+MD%3BRamin%2C+Susan+M%2C+MD%3BMercer%2C+Brian+M%2C+MD&rft.aulast=Tita&rft.aufirst=Alan&rft.date=2009-01-08&rft.volume=360&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=The+New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/10.1056%2FNEJMoa0803267 LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2009 Massachusetts Medical Society. All rights reserved. N1 - Last updated - 2014-09-23 N1 - CODEN - NEJMAG DO - http://dx.doi.org/10.1056/NEJMoa0803267 ER - TY - JOUR T1 - Brief communication: radiographic contrast infusion and catecholamine release in patients with pheochromocytoma. AN - 66805087; 19124817 AB - Contrast-enhanced computed tomography (CT) is useful for localizing pheochromocytoma. However, in patients with suspected pheochromocytoma, CT is often canceled or not performed because of the strong belief that intravenous contrast may induce hypertensive crisis. To examine whether intravenous low-osmolar contrast administration during CT induces catecholamine release that increases blood pressure or heart rate. Prospective study. Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland. 22 patients with pheochromocytoma (15 nonadrenal and 7 adrenal) and 8 unmatched control participants without pheochromocytoma. Plasma catecholamine levels, blood pressure, and heart rate. Plasma catecholamine levels within and between groups did not significantly differ before and after intravenous administration of low-osmolar CT contrast. Patients with pheochromocytoma experienced a clinically and statistically significant increase in diastolic blood pressure that was not accompanied by corresponding increases in plasma catecholamine levels. The difference became non-statistically significant after adjustment for use of alpha- and beta-blockers. The study lacked a placebo group, and the sample was relatively small. Intravenous low-osmolar contrast-enhanced CT can safely be used in patients with pheochromocytoma who are not receiving alpha- or beta-blockers. Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health. JF - Annals of internal medicine AU - Baid, Smita K AU - Lai, Edwin W AU - Wesley, Robert A AU - Ling, Alex AU - Timmers, Henri J L M AU - Adams, Karen T AU - Kozupa, Anna AU - Pacak, Karel AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development and Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1109, USA. Y1 - 2009/01/06/ PY - 2009 DA - 2009 Jan 06 SP - 27 EP - 32 VL - 150 IS - 1 KW - Catecholamines KW - 0 KW - Contrast Media KW - Abridged Index Medicus KW - Index Medicus KW - Osmolar Concentration KW - Young Adult KW - Injections, Intravenous KW - Adrenal Gland Neoplasms -- blood KW - Humans KW - Adrenal Gland Neoplasms -- diagnostic imaging KW - Heart Rate -- drug effects KW - Prospective Studies KW - Adult KW - Middle Aged KW - Blood Pressure -- drug effects KW - Female KW - Male KW - Tomography, X-Ray Computed -- methods KW - Contrast Media -- adverse effects KW - Hypertension -- chemically induced KW - Catecholamines -- blood KW - Tomography, X-Ray Computed -- adverse effects KW - Contrast Media -- administration & dosage KW - Pheochromocytoma -- blood KW - Pheochromocytoma -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66805087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+internal+medicine&rft.atitle=Brief+communication%3A+radiographic+contrast+infusion+and+catecholamine+release+in+patients+with+pheochromocytoma.&rft.au=Baid%2C+Smita+K%3BLai%2C+Edwin+W%3BWesley%2C+Robert+A%3BLing%2C+Alex%3BTimmers%2C+Henri+J+L+M%3BAdams%2C+Karen+T%3BKozupa%2C+Anna%3BPacak%2C+Karel&rft.aulast=Baid&rft.aufirst=Smita&rft.date=2009-01-06&rft.volume=150&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Annals+of+internal+medicine&rft.issn=1539-3704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2009-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur Radiol. 2006 May;16(5):1041-9 [16395531] J Clin Endocrinol Metab. 2004 Feb;89(2):479-91 [14764749] Radiology. 1997 Jan;202(1):227-31 [8988215] JAMA. 1968 Aug 19;205(8):547-53 [5694996] Clin Chem. 1986 Nov;32(11):2030-3 [3096593] Erratum In: Ann Intern Med. 2009 Feb 17;150(4):292 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Semaphorin-Regulated Signaling Networks and Tumor-Induced Angiogenesis T2 - 2009 Keystone Symposia on Angiogenesis and Lymphangiogenesis in Cancer (A2) AN - 41910886; 5113311 JF - 2009 Keystone Symposia on Angiogenesis and Lymphangiogenesis in Cancer (A2) AU - Gutkind, J Y1 - 2009/01/06/ PY - 2009 DA - 2009 Jan 06 KW - Signal transduction KW - Angiogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41910886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Angiogenesis+and+Lymphangiogenesis+in+Cancer+%28A2%29&rft.atitle=Semaphorin-Regulated+Signaling+Networks+and+Tumor-Induced+Angiogenesis&rft.au=Gutkind%2C+J&rft.aulast=Gutkind&rft.aufirst=J&rft.date=2009-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Angiogenesis+and+Lymphangiogenesis+in+Cancer+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=96 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Requirement for EphrinB Activation in Mural Cells Association with Endothelial Cells during New Vessel Formation T2 - 2009 Keystone Symposia on Angiogenesis and Lymphangiogenesis in Cancer (A2) AN - 41908094; 5113305 JF - 2009 Keystone Symposia on Angiogenesis and Lymphangiogenesis in Cancer (A2) AU - Salvucci, Ombretta Y1 - 2009/01/06/ PY - 2009 DA - 2009 Jan 06 KW - Endothelial cells KW - New vessels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41908094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Angiogenesis+and+Lymphangiogenesis+in+Cancer+%28A2%29&rft.atitle=Requirement+for+EphrinB+Activation+in+Mural+Cells+Association+with+Endothelial+Cells+during+New+Vessel+Formation&rft.au=Salvucci%2C+Ombretta&rft.aulast=Salvucci&rft.aufirst=Ombretta&rft.date=2009-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Angiogenesis+and+Lymphangiogenesis+in+Cancer+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=96 5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell-Specific Interactions of the Glucocorticoid Receptor with Chromatin T2 - 2009 Keystone Symposia on Epigenetics, Development and Human Disease (A1) AN - 41902419; 5113922 JF - 2009 Keystone Symposia on Epigenetics, Development and Human Disease (A1) AU - Biddie, Simon Y1 - 2009/01/05/ PY - 2009 DA - 2009 Jan 05 KW - Chromatin KW - Glucocorticoid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2009+Keystone+Symposia+on+Epigenetics%2C+Development+and+Human+Disease+%28A1%29&rft.atitle=Cell-Specific+Interactions+of+the+Glucocorticoid+Receptor+with+Chromatin&rft.au=Biddie%2C+Simon&rft.aulast=Biddie&rft.aufirst=Simon&rft.date=2009-01-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2009+Keystone+Symposia+on+Epigenetics%2C+Development+and+Human+Disease+%28A1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=97 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Extending the Benefits of One Laptop Per Child to Health AN - 57270760; 200903586 AB - Plans to equip every child in developing countries with a computer present possibilities beyond education. Paul Fontelo & colleagues tested the laptop's capabilities in medical settings. Adapted from the source document. JF - BMJ (British Medical Journal) AU - Fontelo, Paul Y1 - 2009/01/03/ PY - 2009 DA - 2009 Jan 03 SP - 20 EP - 22 PB - British Medical Association, BMJ Publishing Group, London UK VL - 338 IS - 7685 SN - 0959-535X, 0959-535X KW - Health care KW - Computers KW - Children KW - Developing countries KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57270760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMJ+%28British+Medical+Journal%29&rft.atitle=Extending+the+Benefits+of+One+Laptop+Per+Child+to+Health&rft.au=Fontelo%2C+Paul&rft.aulast=Fontelo&rft.aufirst=Paul&rft.date=2009-01-03&rft.volume=338&rft.issue=7685&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=BMJ+%28British+Medical+Journal%29&rft.issn=0959535X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - CODEN - BMJOAE N1 - SubjectsTermNotLitGenreText - Computers; Children; Developing countries; Health care ER - TY - JOUR T1 - Visual and proprioceptive feedback improves knee joint position sense AN - 954610455; 14081271 AB - Joint position sense (JPS), one method to assess proprioception, is the ability to replicate a target limb position. Feedback is commonly used to improve motor performance but it has not been demonstrated to improve JPS. The purpose of this study was to determine if feedback decreases error associated with knee JPS at three movement velocities. Healthy volunteers sat with their hip and knees flexed. The knee was passively extended at three velocities (0.5, 2, and 10 degree /s). Subjects were instructed to stop knee motion, via a thumb switch, at a 20 degree knee flexion target. Following movement, each subject received visual and proprioceptive feedback indicating final leg position relative to the target position. Movement velocities and times (4s, 5s, 6s) were randomly presented so subjects could not predict the target position. Measures of JPS included constant error (CE), absolute error (AE), variable error (VE), and percent correct (%CORR). Significant decreases in CE, AE, and VE as well as an increase in %CORR were demonstrated. The majority of JPS improvement (85%) occurred by the tenth trial. Short-term improvements in JPS may be the result of temporary CNS adaptations via feedback that was provided to subjects. Long-term learning of JPS enhancement needs further investigation. JF - Knee Surgery, Sports Traumatology, Arthroscopy AU - Brindle, Timothy J AU - Mizelle, J C AU - Lebiedowska, Maria K AU - Miller, Jeri L AU - Stanhope, Steven J AD - Biomechanics Laboratory, National Institutes of Health, Building 10 CRC, Room 1-1469 10 Center Drive MCS 1604, Bethesda, MD, 20892, USA, Tbrindle@cc.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 40 EP - 47 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 17 IS - 1 SN - 0942-2056, 0942-2056 KW - Physical Education Index KW - Feedback KW - Fingers KW - Hips KW - Joints KW - Knees KW - Movement KW - Sports KW - Surgery KW - Velocity KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954610455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.atitle=Visual+and+proprioceptive+feedback+improves+knee+joint+position+sense&rft.au=Brindle%2C+Timothy+J%3BMizelle%2C+J+C%3BLebiedowska%2C+Maria+K%3BMiller%2C+Jeri+L%3BStanhope%2C+Steven+J&rft.aulast=Brindle&rft.aufirst=Timothy&rft.date=2009-01-01&rft.volume=17&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Knee+Surgery%2C+Sports+Traumatology%2C+Arthroscopy&rft.issn=09422056&rft_id=info:doi/10.1007%2Fs00167-008-0638-3 LA - English DB - Physical Education Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Fingers; Surgery; Knees; Velocity; Feedback; Sports; Movement; Hips; Joints DO - http://dx.doi.org/10.1007/s00167-008-0638-3 ER - TY - JOUR T1 - Normal Sexuality Or Pathological Sexuality? Analysis Of The Dichotomous Sexuality Conception Of The Psychoanalyst Otto Kernberg TT - Sexualidad Normal/Sexualidad Patologica? Analisis de la Concepcion de Sexualidad Dicotomica del Psicoanalista Otto Kernberg AN - 881467694; 201113228 AB - This article proposes the analysis of the dichotomous conception of normal/pathological sexuality presented in the book "Love Relations: Normality and Pathology", by psychoanalyst Otto Kernberg, so as to question the traditional way in which human sexuality is conceived. Adapted from the source document. JF - Revista de Ciencias Sociales (San Jose, Costa Rica) AU - Szuster, Daniela AD - Congregacion B'nei Israel danielaszuster@yahoo.com.ar Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 157 EP - 168 PB - University of Costa Rica, San Jose IS - 4-1 SN - 0482-5276, 0482-5276 KW - Sexuality, Diversity, Psychoanalysis, Theory, Analysis KW - Sexuality KW - Psychology KW - Sociological Theory KW - article KW - 9221: politics and society; politics and society UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881467694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Revista+de+Ciencias+Sociales+%28San+Jose%2C+Costa+Rica%29&rft.atitle=Normal+Sexuality+Or+Pathological+Sexuality%3F+Analysis+Of+The+Dichotomous+Sexuality+Conception+Of+The+Psychoanalyst+Otto+Kernberg&rft.au=Szuster%2C+Daniela&rft.aulast=Szuster&rft.aufirst=Daniela&rft.date=2009-01-01&rft.volume=&rft.issue=4-1&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Revista+de+Ciencias+Sociales+%28San+Jose%2C+Costa+Rica%29&rft.issn=04825276&rft_id=info:doi/ LA - Spanish DB - Worldwide Political Science Abstracts N1 - Date revised - 2011-08-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Psychology; Sociological Theory; Sexuality ER - TY - JOUR T1 - Safety and efficacy of antipsychotic drugs for the behavioral and psychological symptoms of dementia AN - 872139349; 14606947 AB - Antipsychotic drugs are commonly used in the treatment of the behavioral and psychological symptoms of dementia (BPSD). We present a qualitative review of the data on the efficacy and safety of antipsychotic drugs for BPSD. We more specifically examine safety issues with an especial focus on recent research. We examine two safety studies in detail to provide readers with a critical perspective. Typical and atypical antipsychotic drugs both attenuate the severity of BPSD; however, both categories of drugs increase the risk of cerebrovascular and other adverse events, as well as the risk of death. The risk appears greater with the typical drugs, with higher doses, and during the initial weeks of treatment. The risk probably persists for as long as a year after the initiation of treatment. Both drug- and patient-related factors appear to mediate this increase in risk. Antipsychotic drugs should be considered for BPSD only if there is a specific need, or if other treatments have failed; decision-making should be individualized and documented after a risk-benefit analysis. Atypical antipsychotics appear safer than the typical drugs. The lowest effective dose should be used. JF - Indian Journal of Psychiatry AU - Andrade, Chittaranjan AU - Radhakrishnan, Rajiv AD - Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India Y1 - 2009/01// PY - 2009 DA - January 2009 SP - S87 EP - S92 PB - Medknow Publications Pvt. Ltd., A-108/109 Kanara Business Center Mumbai 400075 India VL - 51 IS - 1 SN - 0019-5545, 0019-5545 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Antipsychotics KW - dementia KW - behavioral and psychological symptoms of dementia KW - mortality KW - stroke KW - Risk assessment KW - Mortality KW - Data processing KW - Psychology KW - Decision making KW - Dose-response effects KW - Neuroleptics KW - Reviews KW - Dementia disorders KW - dementia disorders KW - Drugs KW - Side effects KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872139349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Psychiatry&rft.atitle=Safety+and+efficacy+of+antipsychotic+drugs+for+the+behavioral+and+psychological+symptoms+of+dementia&rft.au=Andrade%2C+Chittaranjan%3BRadhakrishnan%2C+Rajiv&rft.aulast=Andrade&rft.aufirst=Chittaranjan&rft.date=2009-01-01&rft.volume=51&rft.issue=1&rft.spage=S87&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Psychiatry&rft.issn=00195545&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Risk assessment; Decision making; Data processing; Reviews; Neuroleptics; Dementia disorders; Drugs; Mortality; Psychology; Dose-response effects; dementia disorders; Side effects ER - TY - JOUR T1 - Automation in an addiction treatment research clinic: Computerised contingency management, ecological momentary assessment and a protocol workflow system AN - 862592621; 201111325 AB - Introduction and Aims. A challenge in treatment research is the necessity of adhering to protocol and regulatory strictures while maintaining flexibility to meet patients' treatment needs and to accommodate variations among protocols. Another challenge is the acquisition of large amounts of data in an occasionally hectic environment, along with the provision of seamless methods for exporting, mining and querying the data. Design and Methods. We have automated several major functions of our outpatient treatment research clinic for studies in drug abuse and dependence. Here we describe three such specialised applications: the Automated Contingency Management (ACM) system for the delivery of behavioural interventions, the transactional electronic diary (TED) system for the management of behavioural assessments and the Protocol Workflow System (PWS) for computerised workflow automation and guidance of each participant's daily clinic activities. These modules are integrated into our larger information system to enable data sharing in real time among authorised staff. Results. ACM and the TED have each permitted us to conduct research that was not previously possible. In addition, the time to data analysis at the end of each study is substantially shorter. With the implementation of the PWS, we have been able to manage a research clinic with an 80 patient capacity, having an annual average of 18 000 patient visits and 7300 urine collections with a research staff of five. Finally, automated data management has considerably enhanced our ability to monitor and summarise participant safety data for research oversight. Discussion and Conclusions. When developed in consultation with end users, automation in treatment research clinics can enable more efficient operations, better communication among staff and expansions in research methods. Adapted from the source document. JF - Drug and Alcohol Review AU - Vahabzadeh, Massoud AU - Lin, Jia-Ling AU - Mezghanni, Mustapha AU - Epstein, David H AU - Preston, Kenzie L AD - Biomedical Informatics Section, Administrative Management Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), NIH/DHHS, Baltimore, Maryland, USA massoudv@nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 3 EP - 11 PB - Wiley-Blackwell, UK VL - 28 IS - 1 SN - 0959-5236, 0959-5236 KW - clinical decision support system contingency management ecological momentary assessment protocol workflow substance abuse treatment KW - Assessment KW - Interventions KW - Automation KW - Contingency learning KW - Clinics KW - Addiction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862592621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Review&rft.atitle=Automation+in+an+addiction+treatment+research+clinic%3A+Computerised+contingency+management%2C+ecological+momentary+assessment+and+a+protocol+workflow+system&rft.au=Vahabzadeh%2C+Massoud%3BLin%2C+Jia-Ling%3BMezghanni%2C+Mustapha%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Vahabzadeh&rft.aufirst=Massoud&rft.date=2009-01-01&rft.volume=28&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Review&rft.issn=09595236&rft_id=info:doi/10.1111%2Fj.1465-3362.2008.00007.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinics; Automation; Contingency learning; Assessment; Addiction; Interventions DO - http://dx.doi.org/10.1111/j.1465-3362.2008.00007.x ER - TY - JOUR T1 - The contribution of the Department of Veterans Affairs to neuroimaging of aphasia: One perspective AN - 85348357; llba-200920515 AB - Background: The Department of Veterans Affairs (VA) has made important contributions to the neuroimaging of aphasia. Through the affiliations of VA researchers with medical faculties, a broad range of questions has been addressed regarding the structural, metabolic, and functional changes that occur in the brain of individuals who develop aphasia. Aims: This report examines some of the work that has been accomplished by VA researchers using CT, MRI, SPECT, and PET imaging approaches. Main Contribution and Conclusions: The reviewed VA research demonstrates that aphasia results from the dynamic relationships that exist between the impact of structural brain damage on brain function in both damaged and non-damaged regions of the brain. The resulting concepts have led to innovative strategies for the neurorehabilitation of aphasia. Adapted from the source document JF - Aphasiology AU - Metter, Jeffrey E AU - Mlcoch, Anthony AD - National Institute on Aging, Baltimore, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1086 EP - 1100 VL - 23 IS - 9 SN - 0268-7038, 0268-7038 KW - *Aphasia (03400) KW - *Magnetic Resonance Imaging (MRI) (50620) KW - *Neuroimaging Techniques (57245) KW - *Medicine (52500) KW - *Armed Forces (04200) KW - *Brain Damage (09400) KW - *Positron Emission Tomography (PET) (66813) KW - article KW - 6414: language-pathological and normal; aphasia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85348357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aphasiology&rft.atitle=The+contribution+of+the+Department+of+Veterans+Affairs+to+neuroimaging+of+aphasia%3A+One+perspective&rft.au=Metter%2C+Jeffrey+E%3BMlcoch%2C+Anthony&rft.aulast=Metter&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=23&rft.issue=9&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=Aphasiology&rft.issn=02687038&rft_id=info:doi/ LA - English DB - ComDisDome N1 - Date revised - 2009-12-01 N1 - Last updated - 2014-06-17 N1 - CODEN - APHAEA N1 - SubjectsTermNotLitGenreText - *Aphasia (03400); *Neuroimaging Techniques (57245); *Medicine (52500); *Magnetic Resonance Imaging (MRI) (50620); *Positron Emission Tomography (PET) (66813); *Brain Damage (09400); *Armed Forces (04200) ER - TY - JOUR T1 - Personal reflections on observational and experimental research approaches to childhood psychopathology AN - 839576456; 201103481 AB - The past 50 years have seen dramatic changes in childhood psychopathology research. The goal of this overview is to contrast observational and experimental research approaches; both have grown more complex such that the boundary between these approaches may be blurred. Both are essential. Landmark observational studies with long-term follow-up (Robins, 1966; Yarrow, Campbell, & Burton, 1970) have had - and continue to have - unique impact on clinical research and practice. Epidemiological studies showed high rates of psychological disorder and their close tie to neurological impairment (Rutter, Tizard, & Whitemore, 1970). These studies have current impact with respect to brain imaging correlates of clinical outcome. Pharmacological studies, particularly those on stimulants and on treatment of pediatric obsessive compulsive disorder (OCD), have propelled experimental methodology and inspired translational approaches. Predicted future trends are: more informed subgrouping of our heterogeneous phenotypes, reliance on multicenter trials, and documentation of non-conventional methods of care delivery. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Rapoport, Judith L AD - Child Psychiatry Branch, NIMH/NIH, Bethesda, MD, USA rapoporj@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 36 EP - 43 PB - Blackwell Publishing, Oxford UK VL - 50 IS - 1-2 SN - 0021-9630, 0021-9630 KW - Attention deficit hyperactivity disorder child psychiatry childhood onset schizophrenia epidemiology experimental research follow-up studies observational research obsessive compulsive disorder pervasive developmental disorder stimulants KW - Paediatrics KW - Care delivery KW - Childhood KW - Psychological disorders KW - Psychopathology KW - Obsessive-Compulsive neuroses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839576456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Personal+reflections+on+observational+and+experimental+research+approaches+to+childhood+psychopathology&rft.au=Rapoport%2C+Judith+L&rft.aulast=Rapoport&rft.aufirst=Judith&rft.date=2009-01-01&rft.volume=50&rft.issue=1-2&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2008.01975.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Obsessive-Compulsive neuroses; Psychopathology; Childhood; Paediatrics; Psychological disorders; Care delivery DO - http://dx.doi.org/10.1111/j.1469-7610.2008.01975.x ER - TY - JOUR T1 - Targeting Protein Kinase C (PKC) and Telomerase by Phenethyl Isothiocyanate (PEITC) Sensitizes PC-3 Cells Towards Chemotherapeutic Drug-Induced Apoptosis AN - 746078779; 12926388 AB - Prostate cancer is the leading cause of cancer-related death in men, incidences of which are increasing gradually in India. Protein kinase C (PKC), an enzyme, gets overexpressed in prostate cancer and results in a resistance to chemotherapy. Telomerase, a reverse transcriptase, is highly activated in prostate cancer cells. Both of these enzymes can be considered as potential molecular markers for prostate cancer. The present study investigates the effects of natural isothiocyanate phenethyl isothiocyanate (PEITC) in modulating the activities of PKC and telomerase in the androgen-independent human prostate adenocarcinoma (PC-3) cell line. We observed that PEITC downregulated the antiapoptotic isoforms (PKC alpha and epsilon) efficiently and zeta moderately. Basal level of PKC delta, a proapoptotic form, was very poor and its modulation was not significant. PEITC also inhibited the activity of telomerase. Studies were conducted to measure the degree of apoptotic cell death induced either by PEITC alone or in combination with adriamycin or etoposide. Apoptosis was evident from the release of mitochondrial cytochrome c, apoptotic index, and by the induction of caspases 3 and 8. PEITC exhibited remarkable efficacy in sensitizing PC-3 cells to undergo cell death by adriamycin and etoposide, which might prove to be of considerable value in synergistic therapy of cancer. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Mukherjee, Sutapa AU - Bhattacharya, Rathindra Kumar AU - Roy, Madhumita AD - Department of Environmental Carcinogenesis & Toxicology, Chittaranjan National Cancer Institute, Kolkata 700 026 Y1 - 2009 PY - 2009 DA - 2009 SP - 269 EP - 282 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 USA VL - 28 IS - 4 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Pollution Abstracts KW - Protein kinase C KW - Apoptosis KW - Pathology KW - Telomerase KW - Chemotherapy KW - Mitochondria KW - Tumor cell lines KW - ISW, India KW - Cytochrome c KW - phenethyl isothiocyanate KW - deltas KW - RNA-directed DNA polymerase KW - prostate cancer KW - Etoposide KW - isothiocyanate KW - Mortality KW - Enzymes KW - Cancer KW - chemotherapy KW - Cytochrome KW - Prostate cancer KW - Caspase-3 KW - Proteins KW - Adenocarcinoma KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746078779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Targeting+Protein+Kinase+C+%28PKC%29+and+Telomerase+by+Phenethyl+Isothiocyanate+%28PEITC%29+Sensitizes+PC-3+Cells+Towards+Chemotherapeutic+Drug-Induced+Apoptosis&rft.au=Mukherjee%2C+Sutapa%3BBhattacharya%2C+Rathindra+Kumar%3BRoy%2C+Madhumita&rft.aulast=Mukherjee&rft.aufirst=Sutapa&rft.date=2009-01-01&rft.volume=28&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Apoptosis; Telomerase; Chemotherapy; Enzymes; Mitochondria; Tumor cell lines; Prostate cancer; Cytochrome c; phenethyl isothiocyanate; Caspase-3; RNA-directed DNA polymerase; Adenocarcinoma; Etoposide; isothiocyanate; Mortality; Cytochrome; Pathology; deltas; Proteins; prostate cancer; chemotherapy; Cancer; ISW, India ER - TY - JOUR T1 - Research Misconduct Policies of Scientific Journals AN - 746009558; 13054696 AB - The purpose of this study was to gather information on the misconduct policies of scientific journals. We contacted editors from a random sample of 399 journals drawn from the ISI Web of Knowledge database. We received 197 responses (49.4% response rate): 54.8% had a policy, and 47.7% had a formal (written) policy; 28.9% had a policy that only outlined procedures for handling misconduct, 15.7% had a policy that only defined misconduct, 10.2% had a policy that included both a definition and procedures; 26.9% of journals had a policy that was generated by the publisher, 13.2% had a policy that was generated by the journal, and 14.7% had a policy that was generated by another source, such as a professional association. We analyzed the relationship between having a policy and impact factor, field of science, publishing house, and nationality. Impact factor was the only variable with a statistically significant association with having a policy. Impact factor was slightly positively associated with whether or not the publisher had a policy, with an odds ratio of 1.49 (P < .0004) per 10 units increase in the impact factor, with a 95% confidence interval (1.20, 1.88). Our research indicates that more than half of scientific journals have developed misconduct policies, but that most of these policies do not define research misconduct and most of these policies were not generated by the journal. JF - Accountability in Research AU - Resnik J.D., DB AU - Peddada, S AU - Brunson, W Jr AD - National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, North Carolina, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 254 EP - 267 VL - 16 IS - 5 SN - 0898-9621, 0898-9621 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746009558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accountability+in+Research&rft.atitle=Research+Misconduct+Policies+of+Scientific+Journals&rft.au=Resnik+J.D.%2C+DB%3BPeddada%2C+S%3BBrunson%2C+W+Jr&rft.aulast=Resnik+J.D.&rft.aufirst=DB&rft.date=2009-01-01&rft.volume=16&rft.issue=5&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Accountability+in+Research&rft.issn=08989621&rft_id=info:doi/10.1080%2F08989620903190299 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1080/08989620903190299 ER - TY - JOUR T1 - Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers AN - 745698870; 13028073 AB - Organophosphate (OP) and N-methyl-carbamate (CB) insecticides are widely used in agriculture in the US and abroad. These compounds - which inhibit acetylcholinestersase (AChE) enzyme activity - continue to be responsible for a high proportion of pesticide poisonings among US agricultural workers. It is possible that some individuals may be especially susceptible to health effects related to OP/CB exposure. The paraoxonase (PON1) enzyme metabolizes the highly toxic oxon forms of some OPs, and an individual's PON1 status may be an important determinant of his or her sensitivity to these chemicals. This chapter discusses methods used to characterize the PON1 status of individuals and reviews previous epidemiologic studies that have evaluated PON1-related sensitivity to OPs in relation to various health endpoints. It also describes an ongoing longitudinal study among OP-exposed agricultural pesticide handlers who are participating in a recently implemented cholinesterase monitoring program in Washington State. This study will evaluate handlers' PON1 status as a hypothesized determinant of butyrylcholinesterase (BuChE) inhibition. Such studies will be useful to determine how regulatory risk assessments might account for differences in PON1-related OP sensitivity when characterizing inter-individual variability in risk related to OP exposure. Recent work assessing newer and more sensitive biomarkers of OP exposure is also discussed briefly in this chapter. JF - Advances in Experimental Medicine and Biology AU - Hofmann, J N AU - Keifer, M C AU - Checkoway, H AU - De Roos, AJ AU - Farin, F M AU - Fenske, R A AU - Richter, R J AU - van Belle, G AU - Furlong, CE AD - Division of Cancer Epidemilogy and Genetics, National Cancer Institute, Bethesda, MD, USA, hofmannjn@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 19 EP - 28 VL - 660 SN - 0065-2598, 0065-2598 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Agriculture KW - Risk assessment KW - Poisoning KW - Handlers KW - Enzymes KW - Aryldialkylphosphatase KW - organophosphates KW - Cholinesterase KW - biomarkers KW - Insecticides KW - Pesticides KW - Occupational exposure KW - W 30940:Products KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745698870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Experimental+Medicine+and+Biology&rft.atitle=Biomarkers+of+Sensitivity+and+Exposure+in+Washington+State+Pesticide+Handlers&rft.au=Hofmann%2C+J+N%3BKeifer%2C+M+C%3BCheckoway%2C+H%3BDe+Roos%2C+AJ%3BFarin%2C+F+M%3BFenske%2C+R+A%3BRichter%2C+R+J%3Bvan+Belle%2C+G%3BFurlong%2C+CE&rft.aulast=Hofmann&rft.aufirst=J&rft.date=2009-01-01&rft.volume=660&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Advances+in+Experimental+Medicine+and+Biology&rft.issn=00652598&rft_id=info:doi/10.1007%2F978-1-60761-350-3_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Agriculture; Insecticides; Pesticides; Poisoning; Aryldialkylphosphatase; Enzymes; Handlers; organophosphates; Cholinesterase; biomarkers; Occupational exposure DO - http://dx.doi.org/10.1007/978-1-60761-350-3_3 ER - TY - JOUR T1 - Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent AN - 744698970; 11741218 AB - Background The obligate intracellular bacterial pathogen Coxiella burnetii causes the zoonosis Q fever. The intracellular niche of C. burnetii has led to the assumption that cell-mediated immunity is the most important immune component for protection against this pathogen. However, passive immunization with immune serum can protect naive animals from challenge with virulent C. burnetii, indicating a role for antibody (Ab) in protection. The mechanism of this Ab-mediated protection is unknown. Therefore, we conducted a study to determine whether Fc receptors (FcR) or complement contribute to Ab-mediated immunity (AMI) to C. burnetii. Results Virulent C. burnetii infects and replicates within human dendritic cells (DC) without inducing their maturation or activation. We investigated the effects of Ab opsonized C. burnetii on human monocyte-derived and murine bone marrow-derived DC. Infection of DC with Ab-opsonized C. burnetii resulted in increased expression of maturation markers and inflammatory cytokine production. Bacteria that had been incubated with naive serum had minimal effect on DC, similar to virulent C. burnetii alone. The effect of Ab opsonized C. burnetii on DC was FcR dependent as evidenced by a reduced response of DC from FcR knockout (FcR k/o) compared to C57Bl/6 (B6) mice. To address the potential role of FcR in Ab-mediated protection in vivo, we compared the response of passively immunized FcR k/o mice to the B6 controls. Interestingly, we found that FcR are not essential for AMI to C. burnetii in vivo. We subsequently examined the role of complement in AMI by passively immunizing and challenging several different strains of complement-deficient mice and found that AMI to C. burnetii is also complement-independent. Conclusion Despite our data showing FcR-dependent stimulation of DC in vitro, Ab-mediated immunity to C. burnetii in vivo is FcR-independent. We also found that passive immunity to this pathogen is independent of complement. JF - BMC Immunology AU - Shannon, Jeffrey G AU - Cockrell, Diane C AU - Takahashi, Kazue AU - Stahl, Gregory L AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA, rheinzen@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 26 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bacteria KW - Immune serum KW - Data processing KW - Bone marrow KW - Pathogens KW - Infection KW - Cell activation KW - Fc receptors KW - Inflammation KW - Immunity (passive) KW - Coxiella burnetii KW - Dendritic cells KW - Antibodies KW - Immunity (cell-mediated) KW - Cytokines KW - Immunization (passive) KW - Monocytes KW - Q fever KW - Opsonization KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744698970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Immunology&rft.atitle=Antibody-mediated+immunity+to+the+obligate+intracellular+bacterial+pathogen+Coxiella+burnetii+is+Fc+receptor-+and+complement-independent&rft.au=Shannon%2C+Jeffrey+G%3BCockrell%2C+Diane+C%3BTakahashi%2C+Kazue%3BStahl%2C+Gregory+L%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=10&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=BMC+Immunology&rft.issn=1471-2172&rft_id=info:doi/10.1186%2F1471-2172-10-26 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2017-02-01 N1 - SubjectsTermNotLitGenreText - Data processing; Immune serum; Bone marrow; Pathogens; Infection; Inflammation; Fc receptors; Cell activation; Immunity (passive); Dendritic cells; Antibodies; Immunity (cell-mediated); Cytokines; Immunization (passive); Monocytes; Q fever; Opsonization; Coxiella burnetii; Bacteria DO - http://dx.doi.org/10.1186/1471-2172-10-26 ER - TY - JOUR T1 - Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1A.GTP pathway AN - 744692719; 12959415 AB - Sigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER)-resident proteins known to be involved in learning and memory. Dendritic spines in hippocampal neurons play important roles in neuroplasticity and learning and memory. This study tested the hypothesis that Sig-1Rs might regulate denritic spine formation in hippocampal neurons and examined potential mechanisms therein. In rat hippocampal primary neurons, the knockdown of Sig-1Rs by siRNAs causes a deficit in the formation of dendritic spines that is unrelated to ER Ca super(2+) signaling or apoptosis, but correlates with the mitochondrial permeability transition and cytochrome c release, followed by caspase-3 activation, Tiam1 cleavage, and a reduction in Rac1A.GTP. Sig-1R-knockdown neurons contain higher levels of free radicals when compared to control neurons. The activation of superoxide dismutase or the application of the hydroxyl-free radical scavenger N-acetyl cysteine (NAC) to the Sig-1R-knockdown neurons rescues dendritic spines and mitochondria from the deficits caused by Sig-1R siRNA. Further, the caspase-3-resistant TIAM1 construct C1199DN, a stable guanine exchange factor able to constitutively activate Rac1 in the form of Rac1A.GTP, also reverses the siRNA-induced dendritic spine deficits. In addition, constitutively active Rac1A.GTP reverses this deficit. These results implicate Sig-1Rs as endogenous regulators of hippopcampal dendritic spine formation and suggest a free radical-sensitive ER-mitochondrion-Rac1A.GTP pathway in the regulation of dendritic spine formation in the hippocampus. JF - Proceedings of the National Academy of Sciences, USA AU - Tsai, Shang-Yi AU - Hayashi, Teruo AU - Harvey, Brandon K AU - Wang, Yun AU - Wu, Wells W AU - Shen, Rong-Fong AU - Zhang, Yongqing AU - Becker, Kevin G AU - Hoffer, Barry J AU - Su, Tsung-Ping Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 22468 EP - 22473 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 52 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - mitochondria KW - ROS KW - N-acetyl cyteine KW - learning and memory KW - caspase-3 KW - Dendritic spines KW - Learning KW - Tiam1 protein KW - Apoptosis KW - Plasticity (hippocampal) KW - Hippocampus KW - Rac1 protein KW - Free radicals KW - Mitochondria KW - Calcium permeability KW - Endoplasmic reticulum KW - Memory KW - Guanine KW - Cytochrome c KW - siRNA KW - Cysteine KW - Superoxide dismutase KW - Neurons KW - Caspase-3 KW - Acetylcysteine KW - Calcium signalling KW - Plasticity (dendritic) KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744692719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Sigma-1+receptors+regulate+hippocampal+dendritic+spine+formation+via+a+free+radical-sensitive+mechanism+involving+Rac1A.GTP+pathway&rft.au=Tsai%2C+Shang-Yi%3BHayashi%2C+Teruo%3BHarvey%2C+Brandon+K%3BWang%2C+Yun%3BWu%2C+Wells+W%3BShen%2C+Rong-Fong%3BZhang%2C+Yongqing%3BBecker%2C+Kevin+G%3BHoffer%2C+Barry+J%3BSu%2C+Tsung-Ping&rft.aulast=Tsai&rft.aufirst=Shang-Yi&rft.date=2009-01-01&rft.volume=106&rft.issue=52&rft.spage=22468&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0909089106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Dendritic spines; Tiam1 protein; Learning; Apoptosis; Plasticity (hippocampal); Hippocampus; Free radicals; Rac1 protein; Mitochondria; Calcium permeability; Endoplasmic reticulum; Guanine; Memory; Cytochrome c; siRNA; Superoxide dismutase; Cysteine; Neurons; Caspase-3; Acetylcysteine; Calcium signalling; Plasticity (dendritic) DO - http://dx.doi.org/10.1073/pnas.0909089106 ER - TY - JOUR T1 - Chronic Exposures to Cholinesterase-inhibiting Pesticides Adversely Affect Respiratory Health of Agricultural Workers in India AN - 744670208; 12554778 AB - Objective: The impact of long term exposure to cholinesterase (ChE)- inhibiting organophosphate (OP) and carbamate (C) pesticides on the respiratory health of agricultural workers in India was investigated. Methods: Three hundred and seventy-six nonsmoking agricultural workers (median age 41 yr) from eastern India who sprayed OP and C pesticides in the field and 348 age- and sex-matched control subjects with non-agricultural occupations from the same locality were enrolled. Prevalence of respiratory symptoms was obtained by questionnaire survey, and pulmonary function tests were carried out by spirometry. Chronic obstructive pulmonary disease (COPD) was diagnosed by the Global Obstructive Lung Disease (GOLD) criteria, and erythrocyte acetylcholinesterase (AChE) was measured by the Ellman method. Results: Agricultural workers had greater prevalences of upper and lower respiratory symptoms, and appreciable reduction in spirometric measurements. Overall, lung function reduction was noted in 48.9% of agricultural workers compared with 22.7% of control, and a restrictive type of deficit was predominant. COPD was diagnosed in 10.9% of agricultural workers compared with 3.4% of controls (p-0.05 in [chi] super(2) test), and the severity of the disease was greater in agricultural workers. Red blood cell (RBC) AChE was lowered by 34.2% in agricultural workers, and the fall in AChE level was positively associated with respiratory symptoms, lung function decrement and COPD after controlling for education and income as potential confounders. Conclusions: Long-term exposure to cholinesterase-inhibiting agricultural pesticides currently in use in India is associated with a reduction in lung function, COPD and a rise in respiratory symptoms. JF - Journal of Occupational Health AU - Chakraborty, Sreeparna AU - Mukherjee, Sayali AU - Roychoudhury, Sanghita AU - Siddique, Shabana AU - Lahiri, Twisha AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute Y1 - 2009 PY - 2009 DA - 2009 SP - 488 EP - 497 PB - Japan Society for Occupational Health, Public Health Bldg., 1-29-8 Shinjuku Shinjuku-ku Tokyo 190 Japan VL - 51 IS - 6 SN - 1341-9145, 1341-9145 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Acetylcholinesterase KW - Occupational exposure KW - India KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744670208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+Health&rft.atitle=Chronic+Exposures+to+Cholinesterase-inhibiting+Pesticides+Adversely+Affect+Respiratory+Health+of+Agricultural+Workers+in+India&rft.au=Chakraborty%2C+Sreeparna%3BMukherjee%2C+Sayali%3BRoychoudhury%2C+Sanghita%3BSiddique%2C+Shabana%3BLahiri%2C+Twisha%3BRay%2C+Manas+Ranjan&rft.aulast=Chakraborty&rft.aufirst=Sreeparna&rft.date=2009-01-01&rft.volume=51&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health&rft.issn=13419145&rft_id=info:doi/10.1539%2Fjoh.L9070 L2 - http://www.jstage.jst.go.jp/article/joh/51/6/488/_pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Occupational exposure; India DO - http://dx.doi.org/10.1539/joh.L9070 ER - TY - JOUR T1 - Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic AN - 744615758; 13002509 AB - In recent years, various nanotechnology platforms in the area of medical biology, including both diagnostics and therapy, have gained remarkable attention. Moreover, research and development of engineered multifunctional nanoparticles as pharmaceutical drug carriers have spurred exponential growth in applications to medicine in the last decade. Design principles of these nanoparticles, including nanoemulsions, dendrimers, nano-gold, liposomes, drug-carrier conjugates, antibody-drug complexes, and magnetic nanoparticles, are primarily based on unique assemblies of synthetic, natural, or biological components, including but not limited to synthetic polymers, metal ions, oils, and lipids as their building blocks. However, the potential success of these particles in the clinic relies on consideration of important parameters such as nanoparticle fabrication strategies, their physical properties, drug loading efficiencies, drug release potential, and, most importantly, minimum toxicity of the carrier itself. Among these, lipid-based nanoparticles bear the advantage of being the least toxic for in vivo applications, and significant progress has been made in the area of DNA/RNA and drug delivery using lipid-based nanoassemblies. In this review, we will primarily focus on the recent advances and updates on lipid-based nanoparticles for their projected applications in drug delivery. We begin with a review of current activities in the field of liposomes (the so-called honorary nanoparticles), and challenging issues of targeting and triggering will be discussed in detail. We will further describe nanoparticles derived from a novel class of amphipathic lipids called bolaamphiphiles with unique lipid assembly features that have been recently examined as drug/DNA delivery vehicles. Finally, an overview of an emerging novel class of particles (based on lipid components other than phospholipids), solid lipid nanoparticles and nanostructured lipid carriers will be presented. We conclude with a few examples of clinically successful formulations of currently available lipid-based nanoparticles. JF - Critical Reviews in Therapeutic Drug Carrier Systems AU - Puri, Anu AU - Loomis, Kristin AU - Smith, Brandon AU - Lee, Jae-Ho AU - Yavlovich, Amichai AU - Heldman, Eliahu AU - Blumenthal, Robert AD - Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 523 EP - 580 PB - Begell House Inc. VL - 26 IS - 6 SN - 0743-4863, 0743-4863 KW - Biotechnology and Bioengineering Abstracts KW - Ions KW - Metals KW - Drug delivery KW - Lipids KW - Oils KW - Toxicity KW - Liposomes KW - RNA KW - Reviews KW - DNA KW - Pharmaceuticals KW - nanoparticles KW - Phospholipids KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744615758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Therapeutic+Drug+Carrier+Systems&rft.atitle=Lipid-Based+Nanoparticles+as+Pharmaceutical+Drug+Carriers%3A+From+Concepts+to+Clinic&rft.au=Puri%2C+Anu%3BLoomis%2C+Kristin%3BSmith%2C+Brandon%3BLee%2C+Jae-Ho%3BYavlovich%2C+Amichai%3BHeldman%2C+Eliahu%3BBlumenthal%2C+Robert&rft.aulast=Puri&rft.aufirst=Anu&rft.date=2009-01-01&rft.volume=26&rft.issue=6&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Therapeutic+Drug+Carrier+Systems&rft.issn=07434863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Drug delivery; Metals; Ions; Lipids; Oils; Toxicity; Liposomes; RNA; Reviews; DNA; Pharmaceuticals; nanoparticles; nanotechnology; Phospholipids ER - TY - JOUR T1 - Social Media Use in the United States: Implications for Health Communication AN - 742900242; 201006703 AB - Background: Given the rapid changes in the communication landscape brought about by participative Internet use and social media, it is important to develop a better understanding of these technologies and their impact on health communication. The first step in this effort is to identify the characteristics of current social media users. Up-to-date reporting of current social media use will help monitor the growth of social media and inform health promotion/communication efforts aiming to effectively utilize social media. Objective: The purpose of the study is to identify the sociodemographic and health-related factors associated with current adult social media users in the United States. Results: Approximately 69% of US adults reported having access to the Internet in 2007. Among Internet users, 5% participated in an online support group, 7% reported blogging, and 23% used a social networking site. Multivariate analysis found that younger age was the only significant predictor of blogging and social networking site participation; a statistically significant linear relationship was observed, with younger categories reporting more frequent use. Younger age, poorer subjective health, and a personal cancer experience predicted support group participation. In general, social media are penetrating the US population independent of education, race/ethnicity, or health care access. Conclusions: Recent growth of social media is not uniformly distributed across age groups; therefore, health communication programs utilizing social media must first consider the age of the targeted population to help ensure that messages reach the intended audience. While racial/ethnic and health statusrelated disparities exist in Internet access, among those with Internet access, these characteristics do not affect social media use. This finding suggests that the new technologies, represented by social media, may be changing the communication pattern throughout the United States. Adapted from the source document. JF - Journal of Medical Internet Research AU - ChoU, Wen-ying Sylvia AU - Hunt, Yvonne M AU - Beckjord, Ellen Burke AU - Moser, Richard P AU - Hesse, Bradford W AD - National Cancer Institute, Health Communication and Informatics Research Branch, 6130 Executive Blvd (EPN), 4051A, Bethesda, MD 20892-7365 Email: chouws@mail.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth Innovation, Toronto, Canada VL - 11 IS - 4 SN - 1438-8871, 1438-8871 KW - USA KW - Internet KW - social media KW - social networking KW - demography KW - population surveillance KW - eHealth, new technologies KW - health communication KW - Web 2.0 KW - Social networks KW - Consumer health information KW - article KW - 14.11: COMMUNICATIONS AND INFORMATION TECHNOLOGY - NETWORKS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742900242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Social+Media+Use+in+the+United+States%3A+Implications+for+Health+Communication&rft.au=ChoU%2C+Wen-ying+Sylvia%3BHunt%2C+Yvonne+M%3BBeckjord%2C+Ellen+Burke%3BMoser%2C+Richard+P%3BHesse%2C+Bradford+W&rft.aulast=ChoU&rft.aufirst=Wen-ying&rft.date=2009-01-01&rft.volume=11&rft.issue=4&rft.spage=NP&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/ L2 - http://www.jmir.org/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumer health information; Internet; Social networks; Web 2.0 ER - TY - JOUR T1 - Neurotrapping: cellular screens to identify the neural substrates of behavior in Drosophila. AN - 734164854; 19949456 AB - The availability of new tools for manipulating neuronal activity, coupled with the development of increasingly sophisticated techniques for targeting these tools to subsets of cells in living, behaving animals, is permitting neuroscientists to tease apart brain circuits by a method akin to classical mutagenesis. Just as mutagenesis can be used to introduce changes into an organism's DNA to identify the genes required for a given biological process, changes in activity can be introduced into the nervous system to identify the cells required for a given behavior. If the changes are introduced randomly, the cells can be identified without any prior knowledge of their properties. This strategy, which we refer to here as "neurotrapping," has been implemented most effectively in Drosophila, where transgenes capable of either suppressing or stimulating neuronal activity can be reproducibly targeted to arbitrary subsets of neurons using so-called "enhancer-trap" techniques. By screening large numbers of enhancer-trap lines, experimenters have been able to identify groups of neurons which, when suppressed (or, in some cases, activated), alter a specific behavior. Parsing these groups of neurons to identify the minimal subset required for generating a behavior has proved difficult, but emerging tools that permit refined transgene targeting are increasing the resolution of the screening techniques. Some of the most recent neurotrapping screens have identified physiological substrates of behavior at the single neuron level. JF - Frontiers in molecular neuroscience AU - White, Benjamin H AU - Peabody, Nathan C AD - Laboratory of Molecular Biology, National Institute of Mental Health Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 20 VL - 2 KW - excitability KW - synaptic KW - genetic KW - neural networks KW - circuits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734164854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Public+Health&rft.atitle=Gene+by+Environment+Interaction+in+Asthma&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Public+Health&rft.issn=01637525&rft_id=info:doi/10.1146%2Fannurev.publhealth.031308.100151 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2009-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Front Mol Neurosci. 2009;2:13 [19750193] Neuron. 2009 Aug 13;63(3):305-15 [19679071] Front Mol Neurosci. 2009;2:21 [19915728] Proc Natl Acad Sci U S A. 1990 Oct;87(20):7844-8 [2236000] Neuron. 1995 Feb;14(2):341-51 [7857643] J Neurosci. 2001 Mar 1;21(5):1523-31 [11222642] Trends Neurosci. 2001 May;24(5):251-4 [11311363] Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12602-7 [11675496] J Neurobiol. 2002 Feb 15;50(3):221-33 [11810637] Cell. 2002 May 17;109(4):485-95 [12086605] J Neurobiol. 2003 May;55(2):233-46 [12672020] Neuron. 2004 May 27;42(4):553-66 [15157418] J Neurobiol. 2005 Jun;63(3):235-54 [15751025] Cell. 2005 Jun 3;121(5):795-807 [15935765] J Neurosci. 2006 Jan 11;26(2):479-89 [16407545] Nature. 2006 Jun 8;441(7094):757-60 [16760980] Curr Biol. 2006 Sep 5;16(17):1741-7 [16950113] Nature. 2007 Jan 11;445(7124):168-76 [17151600] Mol Cell Neurosci. 2007 Jun;35(2):383-96 [17498969] Nature. 2007 Nov 15;450(7168):420-4 [17943086] Nat Neurosci. 2008 May;11(5):538-40 [18391943] Neuron. 2008 Jul 31;59(2):322-35 [18667159] PLoS Biol. 2008 Nov 4;6(11):e273 [18986214] Nat Neurosci. 2009 Mar;12(3):356-62 [19219037] Curr Biol. 2009 Apr 14;19(7):613-9 [19303299] Adv Genet. 2009;65:79-143 [19615532] Front Mol Neurosci. 2009;2:11 [19738923] Front Mol Neurosci. 2009;2:12 [19753326] Science. 1995 Feb 10;267(5199):902-5 [7846534] Development. 1993 Jun;118(2):401-15 [8223268] Genetics. 1999 Mar;151(3):1093-101 [10049925] J Neurobiol. 2001 May;47(2):81-92 [11291099] Neuron. 2001 Sep 13;31(5):699-711 [11567611] Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12596-601 [11675495] Curr Biol. 2001 Dec 11;11(24):R1041-53 [11747845] Adv Genet. 2002;47:1-47 [12000095] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13232-7 [12239352] J Neurosci. 2002 Nov 1;22(21):9490-501 [12417673] J Neurogenet. 2002 Oct-Dec;16(4):205-28 [12745632] Trends Genet. 2004 Aug;20(8):384-91 [15262411] Nature. 2004 Oct 14;431(7010):854-9 [15372051] Cell. 2005 Apr 8;121(1):141-52 [15820685] Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12483-8 [16116081] J Neurosci. 2006 Jan 11;26(2):573-84 [16407556] Nature. 2006 Jun 8;441(7094):753-6 [16760979] J Comp Neurol. 2006 Sep 10;498(2):194-203 [16856137] J Neurosci. 2006 Oct 11;26(41):10380-6 [17035522] Neuron. 2006 Nov 9;52(3):425-36 [17088209] Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5199-204 [17360325] Nature. 2007 Jul 12;448(7150):151-6 [17625558] Curr Opin Neurobiol. 2007 Oct;17(5):572-80 [18024005] Neuron. 2008 Mar 13;57(5):634-60 [18341986] Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9715-20 [18621688] Neuron. 2008 Oct 23;60(2):328-42 [18957224] Neuron. 2008 Nov 26;60(4):672-82 [19038223] Neuron. 2009 Feb 12;61(3):373-84 [19217375] J Neurosci. 2009 Mar 18;29(11):3343-53 [19295141] Science. 2009 May 22;324(5930):1080-4 [19389999] Nature. 2009 Jun 4;459(7247):698-702 [19396159] Nature. 2009 Sep 17;461(7262):407-10 [19759620] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3389/neuro.02.020.2009 ER - TY - JOUR T1 - Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA). AN - 734130413; 19897081 AB - (+/-)-3,4-Methylenedioxymethamphetamine (MDMA) is a commonly abused illicit drug which affects multiple organ systems. In animals, high-dose administration of MDMA produces deficits in serotonin (5-HT) neurons (e.g., depletion of forebrain 5-HT) that have been viewed as neurotoxicity. Recent data implicate MDMA in the development of valvular heart disease (VHD). The present paper reviews several issues related to MDMA-associated neural and cardiac toxicities. The hypothesis of MDMA neurotoxicity in rats is evaluated in terms of the effects of MDMA on monoamine neurons, the use of scaling methods to extrapolate MDMA doses across species, and functional consequences of MDMA exposure. A potential treatment regimen (l-5-hydroxytryptophan plus carbidopa) for MDMA-associated neural deficits is discussed. The pathogenesis of MDMA-associated VHD is reviewed with specific reference to the role of valvular 5-HT(2B) receptors. We conclude that pharmacological effects of MDMA occur at the same doses in rats and humans. High doses of MDMA that produce 5-HT depletions in rats are associated with tolerance and impaired 5-HT release. Doses of MDMA that fail to deplete 5-HT in rats can cause persistent behavioral dysfunction, suggesting even moderate doses may pose risks. Finally, the MDMA metabolite, 3,4-methylenedioxyamphetamine (MDA), is a potent 5-HT(2B) agonist which could contribute to the increased risk of VHD observed in heavy MDMA users. JF - International review of neurobiology AU - Baumann, Michael H AU - Rothman, Richard B AD - Clinical Psychopharmacology Section, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, Maryland 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 257 EP - 296 VL - 88 SN - 0074-7742, 0074-7742 KW - Serotonin Agents KW - 0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Rats KW - Animals KW - Neurons -- drug effects KW - Humans KW - Neurotoxicity Syndromes -- physiopathology KW - Heart Valve Diseases -- chemically induced KW - Brain -- drug effects KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Heart -- drug effects KW - Serotonin Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734130413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Neural+and+cardiac+toxicities+associated+with+3%2C4-methylenedioxymethamphetamine+%28MDMA%29.&rft.au=Baumann%2C+Michael+H%3BRothman%2C+Richard+B&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988010-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-08 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Neurosci. 1990 Jul;13(7):290-6 [1695406] Ann N Y Acad Sci. 1990;600:649-61; discussion 661-4 [1979216] Neuropharmacology. 1990 Nov;29(11):1099-101 [1982341] Annu Rev Pharmacol Toxicol. 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intoxication: brain hyperthermia, blood-brain barrier, brain edema, and morphological cell abnormalities. AN - 734130085; 19897075 AB - Methamphetamine (METH) is a powerful and often abused stimulant with potent addictive and neurotoxic properties. While it is generally assumed that multiple chemical substances released in the brain following METH-induced metabolic activation (or oxidative stress) are primary factors underlying damage of neural cells, in this work we present data suggesting a role of brain hyperthermia and associated leakage of the blood-brain barrier (BBB) in acute METH-induced toxicity. First, we show that METH induces a dose-dependent brain and body hyperthermia, which is strongly potentiated by associated physiological activation and in warm environments that prevent proper heat dissipation to the external environment. Second, we demonstrate that acute METH intoxication induces robust, widespread but structure-specific leakage of the BBB, acute glial activation, and increased water content (edema), which are related to drug-induced brain hyperthermia. Third, we document widespread morphological abnormalities of brain cells, including neurons, glia, epithelial, and endothelial cells developing rapidly during acute METH intoxication. These structural abnormalities are tightly related to the extent of brain hyperthermia, leakage of the BBB, and brain edema. While it is unclear whether these rapidly developed morphological abnormalities are reversible, this study demonstrates that METH induces multiple functional and structural perturbations in the brain, determining its acute toxicity and possibly contributing to neurotoxicity. JF - International review of neurobiology AU - Kiyatkin, Eugene A AU - Sharma, Hari S AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 65 EP - 100 VL - 88 SN - 0074-7742, 0074-7742 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Fever -- chemically induced KW - Animals KW - Neuroglia -- pathology KW - Neurons -- drug effects KW - Humans KW - Poisoning KW - Neuroglia -- drug effects KW - Neurons -- pathology KW - Blood-Brain Barrier -- drug effects KW - Brain Edema -- chemically induced KW - Brain -- drug effects KW - Methamphetamine -- poisoning KW - Central Nervous System Stimulants -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734130085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Acute+methamphetamine+intoxication%3A+brain+hyperthermia%2C+blood-brain+barrier%2C+brain+edema%2C+and+morphological+cell+abnormalities.&rft.au=Kiyatkin%2C+Eugene+A%3BSharma%2C+Hari+S&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988004-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-08 N1 - Date created - 2009-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Hyperthermia. 2000 Jan-Feb;16(1):73-83 [10669318] J Chem Neuroanat. 2009 Jan;37(1):18-32 [18773954] Eur J Pharmacol. 2000 Dec 15;409(3):265-71 [11108820] Brain Res. 2001 Jan 5;888(1):117-127 [11146058] Glia. 2001 Apr 15;34(2):134-42 [11307162] Brain Res. 2001 Jun 29;905(1-2):21-5 [11423075] CMAJ. 2001 Oct 2;165(7):917-28 [11599334] J Appl Physiol (1985). 2002 Jun;92(6):2667-79 [12015388] Di Yi Jun Yi Da Xue Xue Bao. 2003 Jan;23(1):21-4 [12527507] Environ Res. 2003 May;92(1):48-53 [12706754] J Neurosci. 2003 May 1;23(9):3924-9 [12736362] Int J Hyperthermia. 2003 May-Jun;19(3):252-66 [12745971] Int J Hyperthermia. 2003 May-Jun;19(3):325-54 [12745974] Spinal Cord. 2003 Jul;41(7):369-78 [12815368] Neurobiol Aging. 2003 May-Jun;24 Suppl 1:S123-7; discussion S131 [12829120] Neurochem Res. 2003 Aug;28(8):1163-73 [12834255] Eur J Neurosci. 2004 Jul;20(1):51-8 [15245478] Neuroradiology. 2004 Jul;46(7):565-70 [15258709] Can Med Assoc J. 1975 Feb 8;112(3):299-304 [1089034] Experientia. 1975 Dec 15;31(12):1436-7 [1213067] J Neurosurg. 1977 Oct;47(4):525-31 [903805] Brain Res. 1980 Jul 7;193(1):153-63 [7378814] Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(7):1016-20 [4041105] J Neurol Sci. 1986 Jan;72(1):61-76 [2936871] Alcohol Drug Res. 1987;7(3):123-34 [2881551] Am J Physiol. 1988 Feb;254(2 Pt 2):H286-91 [3344819] Brain Res. 1989 May 1;486(1):73-8 [2720435] Neuropharmacology. 1989 Oct;28(10):1145-50 [2554183] Brain Res Dev Brain Res. 1990 Oct 1;56(1):47-53 [2279331] Radiat Res. 1991 Apr;126(1):43-51 [1850533] Neuroscience. 1992 Jun;48(4):889-901 [1630627] Neurochem Res. 1992 Sep;17(9):877-85 [1407275] Pharmacol Biochem Behav. 1993 Jan;44(1):87-98 [8094252] Ann N Y Acad Sci. 1993 May 28;679:195-210 [8512183] J Pharmacol Exp Ther. 1994 Aug;270(2):741-51 [8071867] J Pharmacol Exp Ther. 1994 Aug;270(2):752-60 [8071868] Synapse. 1994 Jul;17(3):203-9 [7974204] Brain Res. 1994 Sep 26;658(1-2):33-8 [7530580] J Pharmacol Exp Ther. 1995 Feb;272(2):868-75 [7853205] J Pharmacol Exp Ther. 1995 Dec;275(3):1104-14 [8531070] NIDA Res Monogr. 1996;163:251-76 [8809863] Ann N Y Acad Sci. 1997 Mar 15;813:572-80 [9100936] Hum Cell. 1996 Dec;9(4):353-66 [9183669] Prog Brain Res. 1998;115:241-74 [9632939] J Pharmacol Exp Ther. 1998 Oct;287(1):107-14 [9765328] Eur J Pharmacol. 1998 Dec 18;363(2-3):107-12 [9881575] Jpn J Pharmacol. 1963 Dec;13:230-9 [14097554] Physiol Behav. 2004 Dec 15;83(3):467-74 [15581669] Curr Pharm Des. 2005;11(11):1353-89 [15853669] Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1689-94 [15650123] Brain Res Brain Res Rev. 2005 Dec 1;50(1):27-56 [15890410] AAPS J. 2006;8(2):E413-8 [16808044] Pain. 2006 Sep;124(1-2):211-21 [16806707] Synapse. 2006 Dec 1;60(7):521-32 [16952162] Ann N Y Acad Sci. 2006 Aug;1074:198-224 [17105918] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] Prog Brain Res. 2007;162:173-99 [17645920] Eur J Neurosci. 2007 Sep;26(5):1242-53 [17767502] Neuron. 2008 Jan 24;57(2):178-201 [18215617] Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1240-6 [10801293] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/S0074-7742(09)88004-5 ER - TY - JOUR T1 - The effect of lipid adjustment on the analysis of environmental contaminants and the outcome of human health risks. AN - 734063492; 19784610 AB - Past literature on exposure to lipophilic agents such as organochlorines (OCs) is conflicting, posing challenges for the interpretation of their potential human health risks. Since blood is often used as a proxy for adipose tissue, it is necessary to model serum lipids when assessing health risks of OCs. Using a simulation study, we evaluated four statistical models (unadjusted, standardized, adjusted, and two-stage) for the analysis of polychlorinated biphenyls (PCBs) exposure, serum lipids, and health outcome risk. Eight candidate true causal scenarios, depicted by directed acyclic graphs, were used to illustrate the ramifications of misspecification of underlying assumptions when interpreting results. Biased results were produced when statistical models that deviated from the underlying causal assumptions were used with the lipid standardization method found to be particularly prone to bias. We concluded that investigators must consider biology, biological medium, laboratory measurement, and other underlying modeling assumptions when devising a statistical model for assessing health outcomes in relation to environmental exposures. JF - Methods in molecular biology (Clifton, N.J.) AU - Gaskins, Audrey J AU - Schisterman, Enrique F AD - Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Schriver National Institute of Child Health and Human Development, NIH, Rockville, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 371 EP - 381 VL - 580 KW - Environmental Pollutants KW - 0 KW - Lipids KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Humans KW - Polychlorinated Biphenyls -- blood KW - Models, Theoretical KW - Lipids -- blood KW - Environmental Exposure -- analysis KW - Environmental Pollutants -- analysis KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734063492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=The+effect+of+lipid+adjustment+on+the+analysis+of+environmental+contaminants+and+the+outcome+of+human+health+risks.&rft.au=Gaskins%2C+Audrey+J%3BSchisterman%2C+Enrique+F&rft.aulast=Gaskins&rft.aufirst=Audrey&rft.date=2009-01-01&rft.volume=580&rft.issue=&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60761-325-1_20 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-13 N1 - Date created - 2009-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 2001 Feb 15;91(4):568-74 [11251983] Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):181-8 [9521429] Am J Epidemiol. 2002 Jan 15;155(2):176-84 [11790682] CA Cancer J Clin. 2002 Sep-Oct;52(5):301-9 [12363327] Int J Epidemiol. 2002 Oct;31(5):1030-7 [12435780] Arch Environ Health. 1970 Apr;20(4):452-7 [5429987] Arch Environ Health. 1983 Jan-Feb;38(1):47-53 [6299210] Bull Environ Contam Toxicol. 1984 Sep;33(3):277-80 [6434008] Toxicol Appl Pharmacol. 1987 Jan;87(1):48-56 [3099428] Arch Environ Health. 1989 Nov-Dec;44(6):351-4 [2514628] Sci Total Environ. 1991 Apr 15;103(2-3):159-75 [1909054] Chemosphere. 1994 Nov-Dec;29(9-11):2287-94 [7850376] Environ Health Perspect. 1995 Oct;103 Suppl 7:141-5 [8593861] Arch Environ Health. 1996 Mar-Apr;51(2):100-7 [8638959] N Engl J Med. 1997 Oct 30;337(18):1253-8 [9345073] J Natl Cancer Inst. 2001 May 16;93(10):768-76 [11353787] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60761-325-1_20 ER - TY - JOUR T1 - Teratogenicity and hyperprolactinemia. AN - 734041764; 19742198 JF - Indian journal of psychiatry AU - Andrade, Chittaranjan AD - Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 62 EP - 64 VL - 51 IS - 1 SN - 0019-5545, 0019-5545 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734041764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+psychiatry&rft.atitle=Teratogenicity+and+hyperprolactinemia.&rft.au=Andrade%2C+Chittaranjan&rft.aulast=Andrade&rft.aufirst=Chittaranjan&rft.date=2009-01-01&rft.volume=51&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+psychiatry&rft.issn=00195545&rft_id=info:doi/10.4103%2F0019-5545.44909 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2009-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epilepsia. 2008 Dec;49(12):2122-4 [18557775] J Clin Psychiatry. 2002;63 Suppl 4:56-62 [11913677] Neurology. 2008 Jul 22;71(4):272-6 [18645165] Reprod Toxicol. 2008 Apr;25(3):388-9 [18424066] J Psychopharmacol. 2008 Mar;22(2 Suppl):70-5 [18477623] CNS Drugs. 2008;22(4):325-34 [18336060] J Clin Psychopharmacol. 2007 Dec;27(6):639-61 [18004132] Am J Psychiatry. 2007 Sep;164(9):1404-10 [17728426] Eur J Neurol. 2006 Jun;13(6):645-54 [16796590] J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):193-8 [16157661] Neurology. 2005 Mar 22;64(6):961-5 [15781808] Neurology. 2005 Mar 22;64(6):955-60 [15781807] Neurology. 2005 Mar 22;64(6):949-54 [15781806] J Clin Endocrinol Metab. 1977 May;44(5):989-93 [558225] Am J Psychiatry. 2004 Apr;161(4):608-20 [15056503] J Clin Psychiatry. 2008 May;69(5):817-29 [18466043] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.4103/0019-5545.44909 ER - TY - JOUR T1 - Fetal alcohol spectrum disorders: when science, medicine, public policy, and laws collide. AN - 734038859; 19731390 AB - Historically, alcohol has been used for different purposes including as a part of religious observances, as a food, at times as a medicine and its well-known use as a beverage. Until relatively recently these purposes have not changed and have at times been at odds with one another, resulting in collisions among policies and practices in science, medicine, public policy and the law. One area in which this has been particularly true is that of fetal alcohol spectrum disorders (FASD) where the adverse consequences of consumed alcohol on children in the womb and after birth may have been observed since antiquity, but the actions taken based on such observations have been influenced as much by the socio/cultural/political context of the times in which they were made as by evidence of harm. This article provides an overview of the inherent confusion when new scientific findings confront prevailing medical practice, the history involved in this confusion with respect to FASD, including public policy and legal issues that have arisen around alcohol and pregnancy, and the research and clinical challenges still being faced. (c) 2009 Wiley-Liss, Inc. JF - Developmental disabilities research reviews AU - Warren, Kenneth R AU - Hewitt, Brenda G AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 170 EP - 175 VL - 15 IS - 3 KW - Index Medicus KW - United States KW - Infant KW - History, 21st Century KW - History, 20th Century KW - Humans KW - History, 18th Century KW - Infant, Newborn KW - History, 19th Century KW - Female KW - Pregnancy KW - Alcoholism -- history KW - Public Policy -- history KW - Fetal Alcohol Spectrum Disorders -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734038859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+disabilities+research+reviews&rft.atitle=Fetal+alcohol+spectrum+disorders%3A+when+science%2C+medicine%2C+public+policy%2C+and+laws+collide.&rft.au=Warren%2C+Kenneth+R%3BHewitt%2C+Brenda+G&rft.aulast=Warren&rft.aufirst=Kenneth&rft.date=2009-01-01&rft.volume=15&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Developmental+disabilities+research+reviews&rft.issn=1940-5529&rft_id=info:doi/10.1002%2Fddrr.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-11 N1 - Date created - 2009-09-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ddrr.71 ER - TY - JOUR T1 - Amphetamine recapitulates developmental programs in the zebrafish. AN - 733943056; 19664194 AB - Addictive drugs hijack the human brain's 'reward' systems. A zebrafish model of addiction has recently been used to query changes in gene expression during this process. JF - Genome biology AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse/IRP, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA. jcadet@intra.nida.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 231 VL - 10 IS - 7 KW - Central Nervous System Stimulants KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Animals KW - Reward KW - Central Nervous System Stimulants -- toxicity KW - Signal Transduction -- drug effects KW - Conditioning, Classical -- drug effects KW - Models, Biological KW - Behavior, Addictive -- genetics KW - Transcription, Genetic -- drug effects KW - Amphetamine -- toxicity KW - Transcription, Genetic -- genetics KW - Zebrafish -- physiology KW - Zebrafish -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733943056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+biology&rft.atitle=Amphetamine+recapitulates+developmental+programs+in+the+zebrafish.&rft.au=Cadet%2C+Jean+Lud&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2009-01-01&rft.volume=10&rft.issue=7&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Genome+biology&rft.issn=1474-760X&rft_id=info:doi/10.1186%2Fgb-2009-10-7-231 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-13 N1 - Date created - 2009-08-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Brain Behav. 2004 Apr;3(2):63-74 [15005714] Neuropharmacology. 2004;47 Suppl 1:33-46 [15464124] Nature. 1981 May 28;291(5813):293-6 [7248006] Prog Neurobiol. 1994 Dec;44(5):497-516 [7886237] Development. 1996 Dec;123:1-36 [9007226] Can J Psychol. 1957 Jun;11(2):104-12 [13426853] Addict Biol. 2005 Mar;10(1):101-18 [15849024] Lab Anim (NY). 2006 May;35(5):33-9 [16645614] Methods. 2006 Jul;39(3):262-74 [16809048] Addict Biol. 2007 Sep;12(3-4):227-462 [17678505] J Clin Invest. 2008 Feb;118(2):454-61 [18246196] Genes Brain Behav. 2008 Mar;7(2):193-202 [17640290] Biochim Biophys Acta. 2008 Aug;1779(8):432-7 [18674649] Neuropharmacology. 2009;56 Suppl 1:73-82 [18647613] Biol Lett. 2009 Feb 23;5(1):112-6 [18755655] Brain Res Rev. 2009 Mar;59(2):253-77 [18762212] Neuron. 2009 May 14;62(3):335-48 [19447090] Genome Biol. 2009;10(7):R81 [19646228] Comment On: Genome Biol. 2009;10(7):R81 [19646228] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/gb-2009-10-7-231 ER - TY - JOUR T1 - Vascular endothelial barrier dysfunction mediated by amyloid-beta proteins. AN - 733867900; 19542618 AB - Neuronal inflammation is very common in Alzheimer's disease (AD). This inflammation can be caused by infiltration of neutrophils across the blood brain barrier. Endothelial permeability changes are required for the infiltration of high molecular weight components to the brain. Deposition of toxic amyloid-beta (A beta) fibrils in the cerebral vasculature, as well as in brain neurons, has been implicated in the development of AD. This study investigates the effect of A beta fibrils on the permeability of the endothelium and the mechanism for the observed permeability changes. A beta(1-40) and A beta(1-42) fibrils, but not monomers, were found to increase permeability of bovine pulmonary arterial endothelial cells in a dose- and time dependent manner as detected by transendothelial electrical resistance. This increase in permeability is only partially (25%) inhibited by catalase and is not associated with an increase in cytosolic Ca+2 or tyrosine phosphorylation. These results indicate that hydrogen peroxide is not the primary mediator for the permeability changes. Treatment of cells with both amyloid fibrils resulted in stress fiber formation, disruption and aggregation of actin filaments, and cellular gap formation. The results of this study reveal that A beta increases the permeability of endothelium by inducing change in the cytoskeleton network. JF - Journal of Alzheimer's disease : JAD AU - Nagababu, Enika AU - Usatyuk, Peter V AU - Enika, Divya AU - Natarajan, Viswanathan AU - Rifkind, Joseph M AD - Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 845 EP - 854 VL - 17 IS - 4 KW - Amyloid beta-Peptides KW - 0 KW - Cytoskeletal Proteins KW - Organophosphates KW - Polymers KW - tyrosine polyphosphate KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Microscopy, Fluorescence KW - Calcium -- metabolism KW - Animals KW - Cattle KW - Blotting, Western KW - Organophosphates -- metabolism KW - Cells, Cultured KW - Electric Impedance KW - Polymers -- metabolism KW - Pulmonary Artery -- cytology KW - Cytoskeletal Proteins -- metabolism KW - Time Factors KW - Endothelium, Vascular -- metabolism KW - Endothelium, Vascular -- cytology KW - Amyloid beta-Peptides -- metabolism KW - Cell Membrane Permeability -- drug effects KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733867900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.atitle=Vascular+endothelial+barrier+dysfunction+mediated+by+amyloid-beta+proteins.&rft.au=Nagababu%2C+Enika%3BUsatyuk%2C+Peter+V%3BEnika%2C+Divya%3BNatarajan%2C+Viswanathan%3BRifkind%2C+Joseph+M&rft.aulast=Nagababu&rft.aufirst=Enika&rft.date=2009-01-01&rft.volume=17&rft.issue=4&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.issn=1875-8908&rft_id=info:doi/10.3233%2FJAD-2009-1104 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-22 N1 - Date created - 2010-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2007 May 23;27(21):5719-29 [17522316] Curr Alzheimer Res. 2007 Apr;4(2):191-7 [17430246] J Neurochem. 2008 Jan;104(2):500-13 [17953673] Brain Pathol. 2008 Apr;18(2):253-66 [18363936] Ann N Y Acad Sci. 2008 Mar;1123:134-45 [18375586] Neurobiol Aging. 2000 May-Jun;21(3):383-421 [10858586] J Struct Biol. 2000 Jun;130(2-3):184-208 [10940225] Am J Physiol Cell Physiol. 2000 Dec;279(6):C1772-81 [11078691] Am J Physiol Cell Physiol. 2001 Apr;280(4):C719-41 [11245588] J Cereb Blood Flow Metab. 2001 Jun;21(6):702-10 [11488539] Microcirculation. 2001 Aug;8(4):207-20 [11528529] J Appl Physiol (1985). 2001 Oct;91(4):1487-500 [11568129] Am J Physiol Cell Physiol. 2001 Dec;281(6):C1940-7 [11698252] Stroke. 2002 Apr;33(4):1152-62 [11935076] Free Radic Biol Med. 2002 Jun 1;32(11):1050-60 [12031889] J Neural Transm (Vienna). 2002 May;109(5-6):813-36 [12111471] Am J Physiol Cell Physiol. 2002 Sep;283(3):C895-904 [12176746] Surgery. 2002 Aug;132(2):180-5 [12219009] Acta Histochem. 2003;105(2):115-25 [12831163] Brain Res Brain Res Rev. 2003 Oct;43(2):207-23 [14572915] Antioxid Redox Signal. 2003 Dec;5(6):723-30 [14588145] J Alzheimers Dis. 2003 Aug;5(4):275-86 [14624023] Endothelium. 2003;10(6):309-17 [14741846] Microcirculation. 2003 Dec;10(6):463-70 [14745459] J Biol Chem. 2004 Mar 19;279(12):11789-97 [14699126] Int J Biochem Cell Biol. 2005 Feb;37(2):289-305 [15474976] Nature. 1987 Feb 19-25;325(6106):733-6 [2881207] Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7919-23 [1518814] Nature. 1992 Sep 24;359(6393):325-7 [1406936] Cell. 1994 Jun 17;77(6):817-27 [8004671] Neuron. 1996 May;16(5):921-32 [8630250] Neurosci Lett. 1996 Mar 15;206(2-3):157-60 [8710175] Am J Physiol. 1996 Jun;270(6 Pt 1):L973-8 [8764222] Nat Med. 1996 Aug;2(8):864-70 [8705854] Acta Neuropathol. 1996;91(1):6-14 [8773140] Am J Physiol. 1996 Feb;270(2 Pt 1):G363-9 [8779980] Life Sci. 1996;59(18):1483-97 [8890929] J Neurosci Res. 1997 Jan 15;47(2):216-23 [9008152] Free Radic Biol Med. 1997;23(1):134-47 [9165306] Am J Physiol. 1997 Jul;273(1 Pt 1):L31-9 [9252537] Am J Physiol. 1997 Jul;273(1 Pt 1):L172-84 [9252554] Ann N Y Acad Sci. 1997 Sep 26;826:161-72 [9329688] Neurosci Lett. 1998 Sep 4;253(2):139-41 [9774169] Am J Physiol. 1999 Jul;277(1 Pt 1):L150-8 [10409242] J Neurosci. 2005 Feb 2;25(5):1149-58 [15689551] Am J Pathol. 2005 Apr;166(4):955-7 [15793276] Int J Mol Med. 2005 Jun;15(6):929-35 [15870895] Cardiovasc Res. 2005 Oct 1;68(1):26-36 [16009356] Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L999-1010 [16040628] FASEB J. 2006 Mar;20(3):426-33 [16507760] Biochim Biophys Acta. 2007 Aug;1768(8):1976-90 [17433250] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3233/JAD-2009-1104 ER - TY - JOUR T1 - Truncation of histone H2A's C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects. AN - 733576900; 19667409 AB - Nickel(II), capable of transforming cells and causing tumors in humans and animals, has been previously shown by us to mediate hydrolytic truncation of histone H2A's C-terminal tail by 8 amino acids in both cell-free and cell culture systems. Since H2A's C-tail is involved in maintaining chromatin structure, such truncation might alter this structure and affect gene expression. To test the latter possibility, we transfected cultured T-REx 293 human embryonic kidney cells with plasmids expressing either wild type (wt) or truncated (q) histone H2A proteins, which were either untagged or N-terminally tagged with fluorescent proteins. Each histone variant was found to be incorporated into chromatin at 24 and 48 hr post-transfection. Cells transfected with the untagged plasmids were tested for gene expression by microarray and real-time PCR. Evaluation of the results for over 21,000 genes using the multidimensional scaling and hierarchical clustering methods revealed significant differences in expression of numerous genes between the q-H2A and wt-H2A transfectants. Many of the differentially expressed genes, including BAZ2A, CLDN18, CYP51A1, GFR, GIPC2, HMGB1, IRF7, JAK3, PSIP1, and VEGF, are cancer-related genes. The results thus demonstrate the potential of q-H2A to contribute to the process of carcinogenesis through epigenetic mechanisms. JF - Annals of clinical and laboratory science AU - Karaczyn, Aldona A AU - Cheng, Robert Y S AU - Buzard, Gregory S AU - Hartley, James AU - Esposito, Dominic AU - Kasprzak, Kazimierz S AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 251 EP - 262 VL - 39 IS - 3 KW - Histones KW - 0 KW - Recombinant Fusion Proteins KW - Nickel KW - 7OV03QG267 KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Up-Regulation -- genetics KW - Amino Acid Sequence KW - Hydrolysis KW - Recombinant Fusion Proteins -- metabolism KW - Gene Expression Profiling KW - Polymerase Chain Reaction KW - Down-Regulation -- genetics KW - Transfection KW - Recombinant Fusion Proteins -- genetics KW - Time Factors KW - Cluster Analysis KW - Cell Line KW - Neoplasms -- etiology KW - Histones -- metabolism KW - Histones -- chemistry KW - Nickel -- metabolism KW - Gene Expression Regulation KW - Histones -- genetics KW - Sequence Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733576900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+clinical+and+laboratory+science&rft.atitle=Truncation+of+histone+H2A%27s+C-terminal+tail%2C+as+is+typical+for+Ni%28II%29-assisted+specific+peptide+bond+hydrolysis%2C+has+gene+expression+altering+effects.&rft.au=Karaczyn%2C+Aldona+A%3BCheng%2C+Robert+Y+S%3BBuzard%2C+Gregory+S%3BHartley%2C+James%3BEsposito%2C+Dominic%3BKasprzak%2C+Kazimierz+S&rft.aulast=Karaczyn&rft.aufirst=Aldona&rft.date=2009-01-01&rft.volume=39&rft.issue=3&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Annals+of+clinical+and+laboratory+science&rft.issn=1550-8080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-14 N1 - Date created - 2009-08-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 1999 May 19;258(3):592-5 [10329430] Br J Haematol. 2006 May;133(3):270-5 [16643428] Biochim Biophys Acta. 2006 Apr;1765(2):148-54 [16386852] Int J Hematol. 2006 Apr;83(3):195-200 [16720547] Expert Rev Mol Med. 2006;8(18):1-11 [16887048] BMC Cancer. 2006;6:186 [16836752] Leukemia. 2006 Oct;20(10):1759-66 [16932349] Int J Biochem Cell Biol. 2007;39(1):171-80 [16979371] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16236-41 [17060627] Mol Cell Biol. 2007 Apr;27(7):2661-75 [17283066] Cancer Res. 2007 Mar 15;67(6):2559-67 [17363574] Cancer Sci. 2007 Jan;98(1):77-82 [17083565] Am J Surg Pathol. 2008 Feb;32(2):188-96 [18223320] Oncogene. 2008 Feb 28;27(10):1404-11 [17828303] Oncogene. 2008 Mar 6;27(11):1511-9 [17873904] Arch Med Res. 2008 May;39(4):365-72 [18375246] Acta Biochim Biophys Sin (Shanghai). 2008 Apr;40(4):297-303 [18401527] Breast J. 2008 May-Jun;14(3):261-7 [18373644] Curr Cancer Drug Targets. 2008 Jun;8(4):253-65 [18537549] J Histochem Cytochem. 2008 Aug;56(8):711-21 [18474937] Mol Med. 2008 Jul-Aug;14(7-8):476-84 [18431461] Cancer Biol Ther. 2008 Jul;7(7):1098-103 [18443431] Biochim Biophys Acta. 2008 Dec;1786(2):178-87 [18541156] Genes Chromosomes Cancer. 1999 Sep;26(1):62-9 [10441007] Cell. 1999 Aug 6;98(3):285-94 [10458604] J Virol. 2004 Dec;78(23):12987-95 [15542650] Front Biosci. 2005 Jan 1;10:866-72 [15569624] Clin Cancer Res. 2005 Jan 1;11(1):226-31 [15671550] Genes Dev. 2005 Feb 1;19(3):295-310 [15687254] Environ Health Perspect. 2005 May;113(5):577-84 [15866766] Clin Cancer Res. 2005 May 15;11(10):3758-65 [15897573] Immunology. 2005 Jul;115(3):358-65 [15946253] J Clin Invest. 2005 Jul;115(7):1765-76 [15965503] Clin Cancer Res. 2005 Oct 15;11(20):7369-75 [16243809] Clin Cancer Res. 2006 Jan 15;12(2):353-60 [16428472] J Pathol. 2006 Apr;208(5):633-42 [16435283] J Hum Genet. 2006;51(4):368-74 [16435073] Genomics. 2000 Jan 1;63(1):40-5 [10662543] Cancer Res. 2000 Mar 15;60(6):1521-5 [10749116] Hum Mol Genet. 2000 Mar 22;9(5):757-63 [10749982] Chem Res Toxicol. 2000 Jul;13(7):616-24 [10898594] Nucleic Acids Res. 2000 Sep 15;28(18):3478-85 [10982866] J Biol Chem. 2000 Nov 10;275(45):34901-8 [10934204] Genome Res. 2000 Nov;10(11):1788-95 [11076863] Radiat Res. 2001 Jan;155(1 Pt 2):181-187 [11121232] Genomics. 2001 Apr 15;73(2):211-22 [11318611] J Biol Chem. 2001 May 25;276(21):18624-32 [11278666] J Biol Chem. 2001 Feb 16;276(7):5074-84 [11085978] Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6599-604 [11381129] Biochem Biophys Res Commun. 2001 Jun 22;284(4):1083-9 [11409905] Biochim Biophys Acta. 2001 Dec 3;1522(2):118-21 [11750063] J Neural Transm Suppl. 2001;(61):95-107 [11771764] Biochem Cell Biol. 2001;79(6):693-708 [11800010] Int J Oncol. 2002 Mar;20(3):571-6 [11836570] J Interferon Cytokine Res. 2002 Jan;22(1):95-101 [11846980] Biochemistry. 2002 May 14;41(19):5945-9 [11993987] Int J Mol Med. 2002 Jun;9(6):585-9 [12011974] Int J Oncol. 2002 Jun;20(6):1183-7 [12011997] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7877-82 [12060735] Biochim Biophys Acta. 2002 Nov 4;1600(1-2):68-73 [12445461] Biochemistry. 2002 Dec 17;41(50):14960-8 [12475245] Mol Carcinog. 2002 Dec;35(4):186-95 [12489110] Am J Pathol. 2003 Jul;163(1):81-9 [12819013] Cancer Metastasis Rev. 2003 Dec;22(4):423-34 [12884916] Toxicol Appl Pharmacol. 2003 Aug 15;191(1):22-39 [12915101] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13225-30 [14578449] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13118-20 [14597707] Brain Res Mol Brain Res. 2003 Nov 26;119(2):216-9 [14625090] Genes Dev. 2003 Nov 15;17(22):2733-40 [14630937] J Cancer Res Clin Oncol. 2003 Dec;129(12):735-6 [14574570] Mutat Res. 2003 Dec 10;533(1-2):67-97 [14643413] Chem Res Toxicol. 2003 Dec;16(12):1555-9 [14680369] J Neurosci. 2004 Feb 18;24(7):1707-18 [14973233] Int J Oncol. 2004 Apr;24(4):1033-8 [15010845] J Invest Dermatol. 2004 May;122(5):1180-7 [15140221] Int J Oncol. 2004 Oct;25(4):821-30 [15375529] Biochim Biophys Acta. 1968 Aug 27;167(1):154-60 [4176710] Biochemistry. 1974 Dec 3;13(25):5128-34 [4373030] Cell. 1976 Dec;9(4 PT 2):785-92 [13934] Eur J Biochem. 1980 Aug;109(1):17-23 [7408874] Nucleic Acids Res. 1983 May 11;11(9):2681-700 [6406983] Ann Clin Lab Sci. 1984 Sep-Oct;14(5):355-65 [6236739] J Biol Chem. 1988 Dec 15;263(35):18972-8 [3058692] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):6845-9 [8041707] Exp Cell Res. 1994 Nov;215(1):63-7 [7957682] Int J Cancer. 1998 Jun 10;76(6):903-8 [9626360] Chem Res Toxicol. 1998 Sep;11(9):1014-23 [9760275] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evolving views of DNA replication (in)fidelity. AN - 733372920; 19903750 AB - "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material" (Watson and Crick 1953). In the years since this remarkable understatement, we have come to realize the enormous complexity of the cellular machinery devoted to replicating DNA with the accuracy needed to maintain genetic information over many generations, balanced by the emergence of mutations on which selection can act. This complexity is partly based on the need to remove or tolerate cytotoxic and mutagenic lesions in DNA generated by environmental stress. Considered here is the fidelity with which undamaged and damaged DNA is replicated by the many DNA polymerases now known to exist. Some of these seriously violate Watson-Crick base-pairing rules such that, depending on the polymerase, the composition and location of the error, and the ability to correct errors (or not), DNA synthesis error rates can vary by more than a millionfold. This offers the potential to modulate rates of point mutations over a wide range, with consequences that can be either deleterious or beneficial. JF - Cold Spring Harbor symposia on quantitative biology AU - Kunkel, T A AD - Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. kunkel@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 91 EP - 101 VL - 74 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Escherichia coli -- metabolism KW - DNA Repair KW - Models, Molecular KW - Humans KW - Escherichia coli -- genetics KW - Models, Biological KW - DNA-Directed DNA Polymerase -- chemistry KW - INDEL Mutation KW - DNA Mismatch Repair KW - Genomic Instability KW - Mutation KW - DNA-Directed DNA Polymerase -- genetics KW - Protein Conformation KW - DNA-Directed DNA Polymerase -- metabolism KW - DNA Replication -- genetics KW - DNA Replication -- physiology KW - Evolution, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733372920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.atitle=Evolving+views+of+DNA+replication+%28in%29fidelity.&rft.au=Kunkel%2C+T+A&rft.aulast=Kunkel&rft.aufirst=T&rft.date=2009-01-01&rft.volume=74&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Cold+Spring+Harbor+symposia+on+quantitative+biology&rft.issn=1943-4456&rft_id=info:doi/10.1101%2Fsqb.2009.74.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-12 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2002 Aug 1;16(15):1872-83 [12154119] Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7160-4 [1831267] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] Biochimie. 1975;57(5):587-95 [1182215] J Mol Biol. 1982 Mar 25;156(1):37-51 [6212689] Annu Rev Biochem. 1982;51:429-57 [6214209] Nature. 1985 Feb 28-Mar 6;313(6005):762-6 [3883192] Mol Gen Genet. 1994 Feb;242(3):289-96 [8107676] J Biol Chem. 1995 Jan 13;270(2):746-50 [7822305] Genetics. 1994 Nov;138(3):553-64 [7851754] Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10144-9 [9294177] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6870-5 [9618505] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10020-5 [9707593] Ann N Y Acad Sci. 1999 May 18;870:100-7 [10415476] Nature. 1953 Apr 25;171(4356):737-8 [13054692] Biochim Biophys Acta. 1956 Jul;21(1):197-8 [13363894] Adv Protein Chem. 2004;69:229-64 [15588845] DNA Repair (Amst). 2003 Feb 3;2(2):135-49 [12531385] Curr Biol. 2003 Apr 29;13(9):744-8 [12725731] Structure. 2003 May;11(5):489-96 [12737815] Cold Spring Harb Symp Quant Biol. 2000;65:81-91 [12760023] Nat Genet. 2003 Jul;34(3):326-9 [12796780] Sci Aging Knowledge Environ. 2003 Feb 26;2003(8):RE3 [12844548] J Biol Chem. 2003 Oct 31;278(44):43770-80 [12882968] Mol Cell Biol. 2005 Jan;25(1):461-71 [15601866] Trends Immunol. 2005 Apr;26(4):215-20 [15797512] Mol Cell. 2005 May 27;18(5):499-505 [15916957] Annu Rev Biochem. 2005;74:681-710 [15952900] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15803-8 [16249340] Curr Biol. 2006 Jan 24;16(2):202-7 [16431373] Chem Rev. 2006 Feb;106(2):302-23 [16464007] Trends Biochem Sci. 2006 Apr;31(4):206-14 [16545956] Cell Cycle. 2006 May;5(9):958-62 [16687920] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18083-8 [17114294] Nat Struct Mol Biol. 2007 Jan;14(1):45-53 [17159995] Science. 2007 Jul 6;317(5834):127-30 [17615360] Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15591-8 [17898175] DNA Repair (Amst). 2007 Dec 1;6(12):1829-38 [17715002] Mol Cell. 2007 Nov 30;28(4):522-9 [18042449] Cell Res. 2008 Jan;18(1):148-61 [18166979] Mol Cell. 2008 Apr 25;30(2):137-44 [18439893] Mech Ageing Dev. 2008 Jul-Aug;129(7-8):391-407 [18406444] Nat Rev Genet. 2008 Aug;9(8):594-604 [18626473] J Mol Biol. 2008 Oct 17;382(4):859-69 [18691598] Trends Cell Biol. 2008 Nov;18(11):521-7 [18824354] Nat Chem Biol. 2009 Feb;5(2):82-90 [19148176] J Biol Chem. 2009 Feb 13;284(7):4041-5 [18835809] Nucleic Acids Res. 2009 Jun;37(11):3774-87 [19380376] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13910-3 [10570172] Annu Rev Biochem. 2000;69:497-529 [10966467] Mol Cell Biol. 2001 Feb;21(3):940-51 [11154280] Science. 2001 Mar 16;291(5511):2156-9 [11251121] Nat Med. 2001 Jun;7(6):638-9 [11385474] Cell. 2001 Jun 1;105(5):657-67 [11389835] Mol Cell. 2001 Jul;8(1):7-8 [11515498] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] Annu Rev Biochem. 2002;71:191-219 [12045095] EMBO J. 1989 Nov;8(11):3511-6 [2555167] Biochemistry. 1991 Jan 15;30(2):538-46 [1988042] DNA Repair (Amst). 2002 Jun 21;1(6):425-35 [12509231] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1101/sqb.2009.74.027 ER - TY - JOUR T1 - Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression. AN - 67623467; 19713955 AB - Small hairpin RNA (shRNA) is a powerful tool for inhibiting gene expression. One limitation has been that this technique has been used primarily to target a single gene. This protocol expands upon previous methods by describing a knockdown vector that facilitates cloning of multiple shRNAs; this allows targeted knockdown of more than one gene or of a single gene that may otherwise be difficult to knockdown using a single shRNA. The targeted gene(s) can be readily re-expressed by transfecting knockdown cells with a knock-in vector, containing an shRNA-refractive cDNA that will express the protein-of-interest even in the presence of shRNAs. The constructed knockdown and knock-in vectors can be easily used concurrently to assess possible interrelationships between genes, the effects of gene loss on cell function and/or their restoration by replacing targeted genes one at a time. The entire knockdown or knock-in procedure can be completed in approximately 3-4 months. JF - Nature protocols AU - Xu, Xue-Ming AU - Yoo, Min-Hyuk AU - Carlson, Bradley A AU - Gladyshev, Vadim N AU - Hatfield, Dolph L AD - Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 1338 EP - 1348 VL - 4 IS - 9 KW - RNA, Small Interfering KW - 0 KW - RNA, Untranslated KW - Index Medicus KW - RNA, Small Interfering -- chemistry KW - Genetic Vectors KW - Gene Expression KW - Mutagenesis KW - Gene Knockout Techniques KW - Transfection -- methods KW - Gene Knock-In Techniques KW - RNA Interference KW - RNA, Untranslated -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67623467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+protocols&rft.atitle=Simultaneous+knockdown+of+the+expression+of+two+genes+using+multiple+shRNAs+and+subsequent+knock-in+of+their+expression.&rft.au=Xu%2C+Xue-Ming%3BYoo%2C+Min-Hyuk%3BCarlson%2C+Bradley+A%3BGladyshev%2C+Vadim+N%3BHatfield%2C+Dolph+L&rft.aulast=Xu&rft.aufirst=Xue-Ming&rft.date=2009-01-01&rft.volume=4&rft.issue=9&rft.spage=1338&rft.isbn=&rft.btitle=&rft.title=Nature+protocols&rft.issn=1750-2799&rft_id=info:doi/10.1038%2Fnprot.2009.145 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: RNA. 1999 Dec;5(12):1561-9 [10606267] Nature. 2002 Jul 11;418(6894):244-51 [12110901] Mol Ther. 2003 Feb;7(2):237-47 [12597912] Antisense Nucleic Acid Drug Dev. 2003;13(3):151-5 [12954115] Nucleic Acids Res. 2004;32(3):893-901 [14769947] Nat Biotechnol. 2004 Mar;22(3):326-30 [14758366] Eur J Cell Biol. 2004 Apr;83(3):113-20 [15202569] Nature. 2004 Jul 8;430(6996):161-4 [15241403] Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):12848-53 [15317934] Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13525-30 [15345743] Biol Chem. 2004 Sep;385(9):791-4 [15493873] Trends Biochem Sci. 1996 Jun;21(6):203-8 [8744353] Cell Cycle. 2004 Sep;3(9):1151-3 [15467445] Methods Enzymol. 2005;392:97-112 [15644177] Nucleic Acids Res. 2005;33(14):4527-35 [16091630] Nucleic Acids Res. 2005;33(15):e131 [16113239] J Biol Chem. 2005 Dec 16;280(50):41568-75 [16230358] Mol Ther. 2006 Jan;13(1):127-34 [16169280] J Virol. 2006 Feb;80(4):1863-73 [16439542] Nat Methods. 2006 Mar;3(3):199-204 [16489337] J Gene Med. 2006 Apr;8(4):433-41 [16389634] J Biol Chem. 2006 May 12;281(19):13005-8 [16565519] Nature. 2006 May 25;441(7092):537-41 [16724069] Anim Genet. 2006 Aug;37(4):369-72 [16879348] Mol Ther. 2006 Oct;14(4):494-504 [16844419] Mol Ther. 2006 Dec;14(6):883-92 [16959541] BMC Biotechnol. 2006;6:50 [17187675] Science. 2007 Jan 26;315(5811):525-8 [17185560] J Biol Chem. 2007 Apr 20;282(16):11960-8 [17337453] PLoS Biol. 2007 Jan;5(1):e4 [17194211] Biochem J. 2007 May 15;404(1):115-20 [17346238] Nucleic Acids Res. 2007;35(8):2620-8 [17426139] RNA. 2007 Jun;13(6):921-9 [17468436] Am J Hum Genet. 2007 Jul;81(1):127-35 [17564969] Curr Opin Mol Ther. 2007 Jun;9(3):248-57 [17608023] Oligonucleotides. 2007 Summer;17(2):237-50 [17638527] J Gene Med. 2007 Sep;9(9):751-63 [17657830] PLoS One. 2007;2(10):e1112 [17971875] Plant Physiol. 2007 Dec;145(4):1272-81 [17766396] BMC Biotechnol. 2007;7:79 [18021456] Mol Ther. 2008 Mar;16(3):557-64 [18180777] Cell Biol Int. 2009 Feb;33(2):158-64 [18996214] BMB Rep. 2008 May 31;41(5):358-62 [18510865] EMBO J. 2001 Dec 3;20(23):6877-88 [11726523] Nucleic Acids Res. 2003 Jan 15;31(2):700-7 [12527779] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/nprot.2009.145 ER - TY - JOUR T1 - Evaluation of fluoren-NU as a novel antitumor agent. AN - 67622224; 19718945 AB - A new nitrososourea derivative, namely fluoren-NU, 3-[2-(3-(2-chloroethyl)-3-nitrosouriedo}ethyl]-spiro[5,9'-fluorenyl]imidazolidine-2,4-dione (compound 2e), was synthesized from 3-(2-bromoethyl)-spiro [5,9'-fluorenyl]imidazolidine-2,4-dione via a four-step synthetic procedure. Its chemical alkylating activity was assessed by coupling with 4-(4-nitrobenzyl)pyridine. In vitro screening in six human tumor cell lines, namely SK-N-SH CNS, IMR-32 neuroblastoma, A549 lung, DU-145 prostate, HL-60 leukemia, and U-937 lymphoma, revealed its significant cytotoxicity in SK-N-SH. Its in vivo antitumoral potency was assessed in murine ascites tumors Ehrlich ascites carcinoma (EAC) and Sarcoma-180 (S-180) by measuring the increase in median survival times (MST) of drug-treated (T) over untreated control (C) mice. Results revealed significant tumor regression effects in both of these tumors. Life span of mice bearing advanced tumor for 5 days before the drug challenge was also considerably increased. In vivo toxicological assay at its optimum dose of 40 mg/kg for days 1-7 treatment schedule was conducted sequentially on day 9, 14, and 19 in normal and EAC-bearing mice. Results revealed that it did not adversely affect hematopoiesis or exhibit drug-induced hepatotoxicity and nephrotoxicity. It has shown minimal cytotoxic effect on human peripheral blood mononuclear cells (PBMC) having a high IC50 value of 792 microM. Compared to Mitonafide and CCNU used as standards it also significantly inhibited DNA and RNA synthesis in EAC tumor cells in vitro at 8 microM concentration. JF - Oncology research AU - Mukherjee, Asama AU - Dutta, Sushanta AU - Chashoo, Gousia AU - Bhagat, Madhulika AU - Saxena, Ajit Kumar AU - Sanyal, Utpal AD - Department of Anticancer Drug Development, Chittaranjan National Cancer Institute, Kolkata 700026, India. Y1 - 2009 PY - 2009 DA - 2009 SP - 387 EP - 396 VL - 17 IS - 9 SN - 0965-0407, 0965-0407 KW - 3-(2-(3-(2-chloroethyl)-3-nitrosouriedo)ethyl)spiro(5,9'-fluorenyl)imidazolidiine-2,4-dione KW - 0 KW - Antineoplastic Agents KW - Hydantoins KW - Nitrosourea Compounds KW - Thymidine KW - VC2W18DGKR KW - Uridine KW - WHI7HQ7H85 KW - Index Medicus KW - Thymidine -- metabolism KW - Drug Evaluation KW - Animals KW - Liver -- drug effects KW - Humans KW - Uridine -- metabolism KW - Mice KW - Cell Line, Tumor KW - Neoplasms, Experimental -- drug therapy KW - Male KW - Nitrosourea Compounds -- pharmacology KW - Hydantoins -- therapeutic use KW - Nitrosourea Compounds -- therapeutic use KW - Hydantoins -- toxicity KW - Antineoplastic Agents -- toxicity KW - Nitrosourea Compounds -- toxicity KW - Hydantoins -- pharmacology KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67622224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+research&rft.atitle=Evaluation+of+fluoren-NU+as+a+novel+antitumor+agent.&rft.au=Mukherjee%2C+Asama%3BDutta%2C+Sushanta%3BChashoo%2C+Gousia%3BBhagat%2C+Madhulika%3BSaxena%2C+Ajit+Kumar%3BSanyal%2C+Utpal&rft.aulast=Mukherjee&rft.aufirst=Asama&rft.date=2009-01-01&rft.volume=17&rft.issue=9&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Oncology+research&rft.issn=09650407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-08 N1 - Date created - 2009-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene by environment interaction in asthma. AN - 67595808; 18980546 AB - Marked international differences in rates of asthma and allergies and the importance of family history highlight the primacy of interactions between genetic variation and the environment in asthma etiology. Environmental tobacco smoke (or secondhand smoke), ambient air pollutants, and endotoxin and/or other pathogen-associated molecular patterns are the ambient exposures studied most frequently for interactions with genetic polymorphisms in asthma. To date, results from the literature remain inconclusive. Most published studies are underpowered to study interactions between genetic polymorphisms and ambient exposures, each with weak effects. Strategies to increase power include cooperation across studies to increase sample sizes and improve measures of both exposure and asthma phenotypes. Genome-wide association studies hold promise for identifying unexpected gene environment interactions, but given the statistical power issues, candidate gene association studies will remain important. New tools are enabling the study of epigenetic mechanisms for environmental interactions. JF - Annual review of public health AU - London, Stephanie J AU - Romieu, Isabelle AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. london2@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 55 EP - 80 VL - 30 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Respiratory Function Tests KW - Genotype KW - Risk Factors KW - Humans KW - Methylation KW - Asthma -- epidemiology KW - Polymorphism, Genetic KW - Asthma -- blood KW - Asthma -- genetics KW - Tobacco Smoke Pollution -- adverse effects KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67595808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+public+health&rft.atitle=Gene+by+environment+interaction+in+asthma.&rft.au=London%2C+Stephanie+J%3BRomieu%2C+Isabelle&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2009-01-01&rft.volume=30&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+public+health&rft.issn=1545-2093&rft_id=info:doi/10.1146%2Fannurev.publhealth.031308.100151 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-08 N1 - Date created - 2009-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1146/annurev.publhealth.031308.100151 ER - TY - JOUR T1 - Green chemistry and workers. AN - 67500570; 19608524 JF - New solutions : a journal of environmental and occupational health policy : NS AU - Hughes, Joseph Chip AU - LeGrande, Dave AU - Zimmerman, Julie AU - Wilson, Michael AU - Beard, Sharon AD - Worker Education and Training Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 239 EP - 253 VL - 19 IS - 2 SN - 1048-2911, 1048-2911 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Environmental Pollution -- prevention & control KW - Inservice Training KW - Humans KW - Environmental Exposure -- prevention & control KW - Environmental Health KW - Chemistry -- organization & administration KW - Employment KW - Labor Unions -- organization & administration KW - Chemical Industry -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67500570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+solutions+%3A+a+journal+of+environmental+and+occupational+health+policy+%3A+NS&rft.atitle=Green+chemistry+and+workers.&rft.au=Hughes%2C+Joseph+Chip%3BLeGrande%2C+Dave%3BZimmerman%2C+Julie%3BWilson%2C+Michael%3BBeard%2C+Sharon&rft.aulast=Hughes&rft.aufirst=Joseph&rft.date=2009-01-01&rft.volume=19&rft.issue=2&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=New+solutions+%3A+a+journal+of+environmental+and+occupational+health+policy+%3A+NS&rft.issn=10482911&rft_id=info:doi/10.2190%2FNS.19.2.dd LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-03 N1 - Date created - 2009-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2190/NS.19.2.dd ER - TY - JOUR T1 - Neonatal estrogenic effects upon the male rat pituitary: early gonadotrophin attenuation precedes long-term recovery. AN - 67463741; 19565361 AB - Neonatal exposure to potent estrogenic compounds can affect multiple components of the male reproductive system causing impaired development of the epithelium and overgrowth of stromal tissue in the epididymis, vas deferens, seminal vesicles, and prostate. However, very little is known about the direct effects of estrogenic compounds on the anterior pituitary gland. In this study we have investigated the effects of neonatal estrogenic exposure upon the anterior pituitary. Both the early- and late-stage effects of exposure to a synthetic estrogenic agent, diethylstilbestrol (DES), upon pituitary gonadotroph cell function were assessed. We administered either a high dose (10 microg) or a low dose (0.1 microg) of DES to male rats during their neonatal period (P2-12). Gonadotroph function, cell number and morphology shortly after DES treatment (P18) and during adulthood (P90) were assessed. At P18 there was a significant decrease in follicle stimulating hormone (FSH) immunoreactivity in the pituitary gonadotroph cells in the high DES dose treated rats compared to control animals. No significant change in luteinizing hormone (LH) was observed at either DES dose. In adulthood (P90), there was no significant difference in FSH or LH gonadotroph immunoreactivity between control rats and any dose of DES-treated rats. Therefore, despite acute and selective ablation of FSH expression the gonadotrophs were able to recover in adulthood, suggesting that perinatal estrogenic exposure was only temporarily deleterious. JF - Neuromolecular medicine AU - Martin, Bronwen AU - Maudsley, Stuart AU - McNeilly, Judith AU - Nicol, Linda AU - Crawford, Janet AU - Millar, Michael AU - Sharpe, Richard M AU - McNeilly, Alan S AD - MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Queen's Medical Research Institute, Edinburgh, UK. martinbro@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 76 EP - 86 VL - 11 IS - 2 KW - Estrogens KW - 0 KW - Follicle Stimulating Hormone, beta Subunit KW - Gonadotropins KW - Luteinizing Hormone, beta Subunit KW - Testosterone KW - 3XMK78S47O KW - Diethylstilbestrol KW - 731DCA35BT KW - Inhibin-beta Subunits KW - 93443-12-0 KW - Index Medicus KW - Rats KW - Animals KW - Inhibin-beta Subunits -- blood KW - Humans KW - Testosterone -- blood KW - Rats, Wistar KW - Diethylstilbestrol -- pharmacology KW - Follicle Stimulating Hormone, beta Subunit -- metabolism KW - Follicle Stimulating Hormone, beta Subunit -- genetics KW - Luteinizing Hormone, beta Subunit -- genetics KW - Luteinizing Hormone, beta Subunit -- metabolism KW - Male KW - Pituitary Gland -- physiology KW - Estrogens -- pharmacology KW - Pituitary Gland -- cytology KW - Gonadotropins -- metabolism KW - Animals, Newborn -- physiology KW - Pituitary Gland -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67463741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuromolecular+medicine&rft.atitle=Neonatal+estrogenic+effects+upon+the+male+rat+pituitary%3A+early+gonadotrophin+attenuation+precedes+long-term+recovery.&rft.au=Martin%2C+Bronwen%3BMaudsley%2C+Stuart%3BMcNeilly%2C+Judith%3BNicol%2C+Linda%3BCrawford%2C+Janet%3BMillar%2C+Michael%3BSharpe%2C+Richard+M%3BMcNeilly%2C+Alan+S&rft.aulast=Martin&rft.aufirst=Bronwen&rft.date=2009-01-01&rft.volume=11&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Neuromolecular+medicine&rft.issn=1559-1174&rft_id=info:doi/10.1007%2Fs12017-009-8075-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-05 N1 - Date created - 2009-07-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12017-009-8075-0 ER - TY - JOUR T1 - Regulatory aspects for translating gene therapy research into the clinic. AN - 67440549; 19565915 AB - Gene therapy products are highly regulated, therefore moving a promising candidate from the laboratory into the clinic can present unique challenges. Success can only be achieved by proper planning and communication within the clinical development team, as well as consultation with the regulatory scientists who will eventually review the clinical plan. Regulators should not be considered as obstacles but rather as collaborators whose advice can significantly expedite the product development. Sound scientific data is required and reviewed by the regulatory agencies to determine whether the potential benefit to the patient population outweighs the risk. Therefore, compliance with Good Manufacturing Practice (GMP) and Good Laboratory Practice (GLP) principles to ensure quality, safety, purity, and potency of the product, and to establish "proof of concept" for efficacy, and for safety information, respectively, is essential. The design and conduct of the clinical trial must adhere to Good Clinical Practice (GCP) principals. The clinical protocol should contain adequate rationale, supported by nonclinical data, to justify the starting dose and regimen, and adequate safety monitoring based on the patient population and the anticipated toxicities. Proper review and approval of gene therapy clinical studies by numerous committees, and regulatory agencies before and throughout the study allows for ongoing risk assessment of these novel and innovative products. The ethical conduct of clinical trials must be a priority for all clinical investigators and sponsors. As history has shown us, only a few fatal mistakes can dramatically alter the regulation of investigational products for all individuals involved in gene therapy clinical research, and further delay the advancement of gene therapy to licensed medicinal products. JF - Methods in molecular biology (Clifton, N.J.) AU - Laurencot, Carolyn M AU - Ruppel, Sheryl AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 397 EP - 421 VL - 542 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - United States KW - Humans KW - Government Regulation KW - Biomedical Research -- legislation & jurisprudence KW - Clinical Medicine -- legislation & jurisprudence KW - Genetic Therapy -- legislation & jurisprudence KW - Clinical Trials as Topic -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67440549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Regulatory+aspects+for+translating+gene+therapy+research+into+the+clinic.&rft.au=Laurencot%2C+Carolyn+M%3BRuppel%2C+Sheryl&rft.aulast=Laurencot&rft.aufirst=Carolyn&rft.date=2009-01-01&rft.volume=542&rft.issue=&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The development of gene therapy: from monogenic recessive disorders to complex diseases such as cancer. AN - 67439445; 19565894 AB - During the last 4 decades, gene therapy has moved from preclinical to clinical studies for many diseases ranging from monogenic recessive disorders such as hemophilia to more complex diseases such as cancer, cardiovascular disorders, and human immunodeficiency virus (HIV). To date, more than 1,340 gene therapy clinical trials have been completed, are ongoing, or have been approved in 28 countries, using more than 100 genes. Most of those clinical trials (66.5%) were aimed at the treatment of cancer. Early hype, failures, and tragic events have now largely been replaced by the necessary stepwise progress needed to realize clinical benefits. We now understand better the strengths and weaknesses of various gene transfer vectors; this facilitates the choice of appropriate vectors for individual diseases. Continuous advances in our understanding of tumor biology have allowed the development of elegant, more efficient, and less toxic treatment strategies. In this introductory chapter, we review the history of gene therapy since the early 1960s and present in detail two major recurring themes in gene therapy: (1) the development of vector and delivery systems and (2) the design of strategies to fight or cure particular diseases. The field of cancer gene therapy experienced an "awkward adolescence." Although this field has certainly not yet reached maturity, it still holds the potential of alleviating the suffering of many individuals with cancer. JF - Methods in molecular biology (Clifton, N.J.) AU - Gillet, Jean-Pierre AU - Macadangdang, Benjamin AU - Fathke, Robert L AU - Gottesman, Michael M AU - Kimchi-Sarfaty, Chava AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 5 EP - 54 VL - 542 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - History, 21st Century KW - History, 20th Century KW - Gene Transfer Techniques KW - Humans KW - Genetic Vectors KW - Genetic Therapy -- history KW - Neoplasms -- therapy KW - Neoplasms -- genetics KW - Genes, Recessive UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67439445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=The+development+of+gene+therapy%3A+from+monogenic+recessive+disorders+to+complex+diseases+such+as+cancer.&rft.au=Gillet%2C+Jean-Pierre%3BMacadangdang%2C+Benjamin%3BFathke%2C+Robert+L%3BGottesman%2C+Michael+M%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Gillet&rft.aufirst=Jean-Pierre&rft.date=2009-01-01&rft.volume=542&rft.issue=&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-561-9_1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-15 N1 - Date created - 2009-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-561-9_1 ER - TY - JOUR T1 - Eradicating malaria. AN - 67404969; 19544698 AB - The renewed interest in malaria research and control is based on the intolerable toll this disease takes on young children and pregnant women in Africa and other vulnerable populations; 150 to 300 children die each hour from malaria amounting to 1 to 2 million deaths yearly. Malaria-induced neurologic impairment, anemia, hypoglycemia, and low birth weight imperil normal development and survival. Resistance of Plasmodium falciparum to drugs and Anopheles mosquitoes to insecticides has stimulated discovery and development of artemisinin-based combination treatments (ACTs) and other drugs, long-lasting insecticide-treated bednets (with synthetic pyrethroids) and a search for non-toxic, long-lasting, affordable insecticides for indoor residual spraying (IRS). Malaria vaccine development and testing are progressing rapidly and a recombinant protein (RTS,S/AS02A) directed against the circumsporozoite protein is soon to be in Phase 3 trials. Support for malaria control, research, and advocacy through the Global Fund for HIV/AIDS, Tuberculosis and Malaria, the U.S. President's Malaria Initiative, the Bill & Melinda Gates Foundation, WHO and other organizations is resulting in decreasing morbidity and mortality in many malarious countries. Sustainability of effective programs through training and institution strengthening will be the key to malaria elimination coupled with improved surveillance and targeted research. JF - Science progress AU - Breman, Joel G AD - Fogarty International Center (FIC) of the US National Institutes of Health, Bethesda, Maryland 20892, USA. jbreman@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1 EP - 38 VL - 92 SN - 0036-8504, 0036-8504 KW - Antimalarials KW - 0 KW - Artemisinins KW - Lactones KW - Malaria Vaccines KW - artemisin KW - Y1R67R7XWU KW - Index Medicus KW - Animals KW - Pregnancy Complications -- prevention & control KW - Humans KW - Pregnancy Complications -- parasitology KW - Artemisinins -- therapeutic use KW - Child KW - Pregnancy KW - Global Health KW - Anopheles -- drug effects KW - Lactones -- therapeutic use KW - Anopheles -- parasitology KW - Malaria Vaccines -- therapeutic use KW - Antimalarials -- therapeutic use KW - Female KW - Malaria -- prevention & control KW - Malaria -- epidemiology KW - Malaria -- drug therapy KW - Malaria -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67404969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+progress&rft.atitle=Eradicating+malaria.&rft.au=Breman%2C+Joel+G&rft.aulast=Breman&rft.aufirst=Joel&rft.date=2009-01-01&rft.volume=92&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Science+progress&rft.issn=00368504&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-06-23 N1 - Date revised - 2017-01-30 N1 - Last updated - 2017-01-30 ER - TY - JOUR T1 - Airway inflammation and upregulation of beta2 Mac-1 integrin expression on circulating leukocytes of female ragpickers in India. AN - 67390912; 19372628 AB - Over one million ragpickers collect and sale recyclable materials from municipal solid wastes (MSW) in India for a living. Since MSW contains a host of pathogenic microorganisms, we investigated the occurrence of airway inflammation and its underlying mechanism in 52 non-smoking female ragpickers (median age 29 yr) and 42 control women matched for age, smoking habit and socioeconomic conditions in Kolkata, eastern India. Spontaneously expectorated sputum were stained using the Papanicolau method for cytology, and flow cytometry was used for measurements of surface expression of beta(2) Mac-1 integrin (CD11b/CD18) on leukocytes and P-selectin on platelets. The concentrations of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and chemokine interleukin-8 (IL-8) were measured in plasma by enzyme-linked immunosorbent assay. Compared with controls, sputum samples of ragpickers contained significantly increased numbers of alveolar macrophages, neutrophils, eosinophils and lymphocytes, suggesting airway inflammation. Circulating neutrophils and monocytes of the ragpickers overexpressed CD11b/CD18 and their platelets had upregulated surface expression of P-selectin, implying functional activation of these cells. In addition, plasma levels of IL-8 and TNF-alpha were significantly increased, indicating greater trafficking of leukocytes from circulation to the tissues. Multivariate logistic regression analysis demonstrated a positive association between the ragpicking profession and leukocyte activation after controlling for potential confounders. Ragpickers experience leukocyte and platelet activation and airway inflammation that could make them more vulnerable to tissue damage and cardiovascular diseases. JF - Journal of occupational health AU - Ray, Manas Ranjan AU - Roychoudhury, Sanghita AU - Mukherjee, Sayali AU - Siddique, Shabana AU - Banerjee, Madhuchanda AU - Akolkar, A B AU - Sengupta, B AU - Lahiri, Twisha AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata, India. manasrray@rediffmail.com Y1 - 2009 PY - 2009 DA - 2009 SP - 232 EP - 238 VL - 51 IS - 3 KW - Macrophage-1 Antigen KW - 0 KW - P-Selectin KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Poverty KW - P-Selectin -- blood KW - Humans KW - Adult KW - Tumor Necrosis Factor-alpha -- blood KW - P-Selectin -- metabolism KW - Middle Aged KW - Garbage KW - Tumor Necrosis Factor-alpha -- metabolism KW - Female KW - India KW - Leukocytes -- metabolism KW - Macrophage-1 Antigen -- metabolism KW - Bronchitis -- etiology KW - Macrophage-1 Antigen -- blood KW - Bronchitis -- physiopathology KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67390912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+health&rft.atitle=Airway+inflammation+and+upregulation+of+beta2+Mac-1+integrin+expression+on+circulating+leukocytes+of+female+ragpickers+in+India.&rft.au=Ray%2C+Manas+Ranjan%3BRoychoudhury%2C+Sanghita%3BMukherjee%2C+Sayali%3BSiddique%2C+Shabana%3BBanerjee%2C+Madhuchanda%3BAkolkar%2C+A+B%3BSengupta%2C+B%3BLahiri%2C+Twisha&rft.aulast=Ray&rft.aufirst=Manas&rft.date=2009-01-01&rft.volume=51&rft.issue=3&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+health&rft.issn=1348-9585&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-22 N1 - Date created - 2009-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional analysis of mutant mitochondrial DNA polymerase proteins involved in human disease. AN - 67350027; 19513667 AB - DNA polymerase gamma (pol gamma) is the only DNA polymerase within the mitochondrion and is thus essential for replication and repair of mtDNA. POLG, the gene encoding the catalytic subunit of pol gamma, is a major locus for a wide spectrum of mitochondrial diseases with more than 100 known disease mutations. Thus, we need to understand how and why pol gamma defects lead to disease. By using an extensive array of methods, we are developing a clearer understanding of how defects in pol gamma contribute to disease. Furthermore, crucial knowledge concerning the role of pol gamma in mtDNA replication and repair can be acquired. Here we present the protocols to characterize mutant DNA pol gamma proteins, namely, assays for processive DNA synthesis, exonuclease activity, DNA binding, subunit interaction, and protein stability. JF - Methods in molecular biology (Clifton, N.J.) AU - Chan, Sherine S L AU - Copeland, William C AD - Mitochondrial DNA Replication Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 59 EP - 72 VL - 554 SN - 1064-3745, 1064-3745 KW - DNA, Mitochondrial KW - 0 KW - Mutant Proteins KW - Protein Subunits KW - Recombinant Proteins KW - DNA polymerase gamma KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Exonucleases KW - EC 3.1.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- isolation & purification KW - Recombinant Proteins -- metabolism KW - Humans KW - Enzyme Stability KW - Electrophoretic Mobility Shift Assay KW - Immunoprecipitation KW - Circular Dichroism KW - Recombinant Proteins -- genetics KW - Exonucleases -- metabolism KW - Mutant Proteins -- genetics KW - Mitochondrial Diseases -- genetics KW - DNA-Directed DNA Polymerase -- isolation & purification KW - Mutant Proteins -- isolation & purification KW - Mitochondrial Diseases -- metabolism KW - Mutant Proteins -- metabolism KW - DNA, Mitochondrial -- metabolism KW - Mutation -- genetics KW - DNA-Directed DNA Polymerase -- genetics KW - DNA-Directed DNA Polymerase -- metabolism KW - DNA, Mitochondrial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67350027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Functional+analysis+of+mutant+mitochondrial+DNA+polymerase+proteins+involved+in+human+disease.&rft.au=Chan%2C+Sherine+S+L%3BCopeland%2C+William+C&rft.aulast=Chan&rft.aufirst=Sherine+S&rft.date=2009-01-01&rft.volume=554&rft.issue=&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-521-3_4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-09 N1 - Date created - 2009-06-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] J Infect Dis. 2007 May 15;195(10):1419-25 [17436221] J Biol Chem. 2002 May 3;277(18):15225-8 [11897778] J Mol Biol. 2003 May 23;329(1):45-57 [12742017] Biochemistry. 2003 Aug 19;42(32):9564-74 [12911298] Nat Struct Mol Biol. 2004 Aug;11(8):770-6 [15258572] Biochemistry. 1998 Jul 21;37(29):10529-39 [9671525] Hum Mol Genet. 2005 Jul 15;14(14):1907-20 [15917273] Ann Med. 2005;37(3):222-32 [16019721] J Biol Chem. 2005 Sep 9;280(36):31341-6 [16024923] DNA Repair (Amst). 2005 Dec 8;4(12):1381-9 [16181814] J Biol Chem. 2006 Jan 6;281(1):374-82 [16263719] Chem Rev. 2006 Feb;106(2):383-405 [16464011] Am J Hum Genet. 2006 Jun;78(6):1026-34 [16685652] Hum Mol Genet. 2006 Dec 1;15(23):3473-83 [17088268] J Biol Chem. 2001 Jun 29;276(26):23616-23 [11319228] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-521-3_4 ER - TY - JOUR T1 - Gemcitabine and carboplatin treatment in patients with relapsing ovarian cancer. AN - 67281794; 19473054 AB - Despite progress in primary treatment of patients with advanced ovarian cancer, the majority develop recurrence of the disease. A platinum salt treatment, either as monotherapy or in combination with another cytostatic agent, is indicated for patients who have relapsed 6 or more months after primary treatment and thus have platinum-sensitive relapse. Because repeated use of paclitaxel treatment may lead to substantial neurotoxicity, the combination of gemcitabine with carboplatin represents a suitable treatment option, which is widely used in common clinical practice in the Czech Republic and Slovakia. This non-interventional, prospective study observed the effectiveness and tolerability of second-line treatment with gemcitabine and carboplatin in patients with platinum-sensitive relapse of ovarian cancer in routine clinical practice. The primary endpoint was to evaluate the survival and secondary endpoints were to evaluate time to disease progression, objective tumor response rate, and treatment toxicity. Patients were enrolled to planned second-line treatment with gemcitabine and carboplatin (gemcitabine 1000 mg/m2 and carboplatin AUC 5 on Day 1, and gemcitabine 1000 mg/m2 on Day 8 of a 21-day cycle) for platinum-sensitive relapse of ovarian cancer as a part of routine clinical practice and followed for 12 months. The events (death, tumor progression), tumor response, and maximal grades of toxicity were recorded according to common clinical practice. Survival time (using Kaplan-Meier analysis) and objective tumor response rate were calculated using data forms, and a subgroup analysis was performed using log rank tests for time-to-event endpoints; p-values were also calculated. Response rates were calculated for the whole population; for the subgroups, the Fisher's exact test was performed and only p-values were calculated. Between January 2004 and June 2005, 53 patients were enrolled in the study. The median age was 57 years and 96% of patients had an Eastern Cooperative Oncology Group Performance Status (ECOG-PS) of 0 and 1 at baseline. Approximately 91% of patients were originally diagnosed with stage III or IV; 60% of patients had disease free intervals (DFIs) of 12 or more months from previous therapy, and the additional 40% less than 12 months. The 1-year survival rate was 83%. Median survival time was not determined within the 12-month period following the start of the treatment study due to the limited duration of follow-up. Objective tumour response rate was 67.3%. Most common reasons for discontinuation of therapy were "Planned treatment completed" (53%) and "Tumor progression" (11%). Most common toxicities were leukopenia, anaemia, neutropenia, and thrombocytopenia; grades 3 and 4 of these toxicity types did not exceed 30%. Febrile neutropenia was recorded in two patients. Most common non-haematological toxicities were nausea and vomiting, fatigue, and neuropathy; grades 3 and 4 of these were below 6%. Results on time to disease progression are not published due to inconsistent statistical analysis of reported data. Based on this observation from routine clinical practice, which corresponds with previously published results from controlled clinical trials, the gemcitabine and carboplatin combination seems to be a suitable therapeutic option for patients with platinum-sensitive relapse of ovarian cancer. JF - Neoplasma AU - Sufliarsky, J AU - Chovanec, J AU - Svetlovska, D AU - Minarik, T AU - Packan, T AU - Kroslakova, D AU - Lalabova, R AU - Helpianska, L AU - Horvathova, D AU - Sevcik, L AU - Spacek, J AU - Laluha, A AU - Tkacova, V AU - Malec, V AU - Rakicka, G AU - Magdin, D AU - Jancokova, I AU - Dorr, A AU - Stresko, M AU - Habetinek, V AU - Koza, I AD - National Cancer Institute Bratislava, 833 10 Brtaislava, Slovakia, Czech Republic. jozef.sufliarsky@nou.sk Y1 - 2009 PY - 2009 DA - 2009 SP - 291 EP - 297 VL - 56 IS - 4 SN - 0028-2685, 0028-2685 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Carboplatin KW - BG3F62OND5 KW - Index Medicus KW - Young Adult KW - Neoplasm Staging KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Prognosis KW - Endometrial Neoplasms -- drug therapy KW - Disease Progression KW - Aged KW - Carboplatin -- administration & dosage KW - Carcinoma, Endometrioid -- secondary KW - Cystadenocarcinoma, Serous -- secondary KW - Adenocarcinoma, Mucinous -- secondary KW - Prospective Studies KW - Cystadenocarcinoma, Serous -- drug therapy KW - Survival Rate KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Adenocarcinoma, Mucinous -- drug therapy KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Endometrial Neoplasms -- secondary KW - Immunoenzyme Techniques KW - Female KW - Carcinoma, Endometrioid -- drug therapy KW - Neoplasm Recurrence, Local -- drug therapy KW - Ovarian Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Ovarian Neoplasms -- drug therapy KW - Neoplasm Recurrence, Local -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67281794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasma&rft.atitle=Gemcitabine+and+carboplatin+treatment+in+patients+with+relapsing+ovarian+cancer.&rft.au=Sufliarsky%2C+J%3BChovanec%2C+J%3BSvetlovska%2C+D%3BMinarik%2C+T%3BPackan%2C+T%3BKroslakova%2C+D%3BLalabova%2C+R%3BHelpianska%2C+L%3BHorvathova%2C+D%3BSevcik%2C+L%3BSpacek%2C+J%3BLaluha%2C+A%3BTkacova%2C+V%3BMalec%2C+V%3BRakicka%2C+G%3BMagdin%2C+D%3BJancokova%2C+I%3BDorr%2C+A%3BStresko%2C+M%3BHabetinek%2C+V%3BKoza%2C+I&rft.aulast=Sufliarsky&rft.aufirst=J&rft.date=2009-01-01&rft.volume=56&rft.issue=4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Neoplasma&rft.issn=00282685&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-06 N1 - Date created - 2009-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Rhinacanthus nasutus kurz on colon carcinogenesis in mice. AN - 67279193; 19469634 AB - Rhinacanthus nasutus Kurz, a Thai medicinal plant which possess antiproliferative and pro-apoptotic effects on human cancer cells, was examined for chemopreventive potential against colonic neoplasms induced by azoxymethane (AOM) combined with dextran sodium sulfate (DSS) in mice. Male ICR mice were given a single intraperitoneal administration of AOM (10 mg/kg body weight) followed by 2% DSS in their drinking water for a week. Water extract of the roots of R. nasutus (RNR) was given to the animals intragastrically daily in the initiation and promotion phases. The one hundred mice were divided into 8 groups, one group treated with AOM plus DSS serving as a control. Four other groups received AOM/DSS and RNR at 100 or 500 mg/kg body weight for 5 weeks (initiation phase study) and for 14 weeks (promotion phase study). Another two groups were given RNR alone at 100 and 500 mg/kg body weight and the last group was maintained untreated. At the end of the study, we found that the incidence and multiplicity of colonic tumors in mice fed with RNR both at 100 and 500 mg/kg body weight in initiation phase were higher than those in the control group. Moreover, RNR feeding during the promotion phase also gave similar results. Our results suggest that water extract of the roots of R. nasutus Kurz. has no preventive potential against colon carcinogenesis induced by AOM/DSS in mice, rather increasing the incidence of colonic tumors when given during initiation and promotion phases. Further study on RNR should provide more information on mechanisms of its tumor promotion activity. JF - Asian Pacific journal of cancer prevention : APJCP AU - Kupradinun, Piengchai AU - Siripong, Pongpun AU - Chanpai, Rittichai AU - Piyaviriyagul, Suratsawadee AU - Rungsipipat, Anudep AU - Wangnaitham, Supradit AD - National Cancer Institute, Bangkok, Thailand. pkupradi@health.moph.go.th PY - 2009 SP - 103 EP - 106 VL - 10 IS - 1 SN - 1513-7368, 1513-7368 KW - Carcinogens KW - 0 KW - Plant Extracts KW - Dextran Sulfate KW - 9042-14-2 KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Thailand KW - Mice KW - Male KW - Plant Extracts -- pharmacology KW - Plant Roots KW - Plants, Medicinal KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- chemically induced KW - Acanthaceae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67279193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Effects+of+Rhinacanthus+nasutus+kurz+on+colon+carcinogenesis+in+mice.&rft.au=Kupradinun%2C+Piengchai%3BSiripong%2C+Pongpun%3BChanpai%2C+Rittichai%3BPiyaviriyagul%2C+Suratsawadee%3BRungsipipat%2C+Anudep%3BWangnaitham%2C+Supradit&rft.aulast=Kupradinun&rft.aufirst=Piengchai&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.issn=1179-190X&rft_id=info:doi/10.2165%2F00063030-200923010-00001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-26 N1 - Date created - 2009-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neem (Azadirachta indica) leaf preparation prevents leukocyte apoptosis mediated by cisplatin plus 5-fluorouracil treatment in Swiss mice. AN - 67248675; 19346744 AB - Neem (Azadirachta indica) is widely regarded as a wonder tree because of its diverse medicinal applications. We investigated the ability of neem leaf preparation (NLP) to protect against apoptosis of circulating blood cells induced by cisplatin and 5-fluorouracil (cis + 5-FU) in carcinoma-bearing mice. Apoptosis was studied by annexin V-propidium iodide method. Total white blood cell count was performed using 3% glacial acetic acid on hemocytometer. Cytotoxicity was determined by LDH release assay and T/NK cell status was determined by flow cytometry. In comparison to untreated control, during cis + 5-FU therapy, significant down-regulation of leukocyte apoptosis was noted in mice pretreated with NLP or granulocyte colony stimulating factor (GCSF) during cis + 5-FU therapy. This enhanced cytotoxicity may be associated with NLP-induced increase of the cytotoxic T and NK cell pool. Efficacy of NLP is comparable to GCSF in its ability to protect against leukocyte apoptosis induced by cis + 5-FU. NLP would be a better choice of treatment because GCSF is tumor promoting, angiogenic and expensive. Copyright 2009 S. Karger AG, Basel. JF - Chemotherapy AU - Ghosh, Diptendu AU - Bose, Anamika AU - Haque, Enamul AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2009 PY - 2009 DA - 2009 SP - 137 EP - 144 VL - 55 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Plant Extracts KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Cisplatin KW - Q20Q21Q62J KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Animals KW - Mice KW - Plant Leaves -- chemistry KW - Granulocyte Colony-Stimulating Factor -- pharmacology KW - Fluorouracil -- therapeutic use KW - Plant Extracts -- pharmacology KW - Cisplatin -- therapeutic use KW - Apoptosis KW - Fluorouracil -- toxicity KW - Leukocytes -- physiology KW - Cisplatin -- toxicity KW - Antineoplastic Agents -- toxicity KW - Azadirachta -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Leukocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67248675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemotherapy&rft.atitle=Neem+%28Azadirachta+indica%29+leaf+preparation+prevents+leukocyte+apoptosis+mediated+by+cisplatin+plus+5-fluorouracil+treatment+in+Swiss+mice.&rft.au=Tarca%2C+Adi+Laurentiu%3BDraghici%2C+Sorin%3BKhatri%2C+Purvesh%3BHassan%2C+Sonia+S%3BMittal%2C+Pooja%3BKim%2C+Jung-sun%3BKim%2C+Chong+Jai%3BKusanovic%2C+Juan+Pedro%3BRomero%2C+Roberto&rft.aulast=Tarca&rft.aufirst=Adi&rft.date=2009-01-01&rft.volume=25&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn577 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-28 N1 - Date created - 2009-05-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000211558 ER - TY - JOUR T1 - Epidemiologic studies in agricultural populations: observations and future directions. AN - 67244568; 19437268 AB - This paper reviews epidemiologic studies of cancer among agricultural populations to identify possible associations and to provide a focus for future investigations. Meta-analyses of mortality surveys of farmers find excesses of several cancers, including connective tissue, non-Hodgkin's lymphoma, Hodgkin's disease, multiple myeloma and cancers of the skin, stomach, and brain, and deficits for total mortality, heart disease, total cancer, and cancers of the esophagus, colon, lung, and bladder. Meta-analyses of studies of individual cancers also support these findings, indicating a need to identify exposures and lifestyle factors that might account for this mortality pattern. Although cancer studies of other occupations that might have pesticide exposures in common with farmers show some similarities with observations among farmers, the overall patterns are quite different. This suggests that pesticides are not likely to fully explain the cancer and other disease patterns observed among farmers. Because exposures vary by type of farm operation, exposures for individual farmers can differ considerably. Studies in the future need to focus on the full range of exposures to fully understand the cancer pattern in farmers. JF - Journal of agromedicine AU - Blair, Aaron AU - Freeman, Laura Beane AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA. blaira@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 125 EP - 131 VL - 14 IS - 2 KW - Agrochemicals KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Occupational Exposure -- adverse effects KW - Meta-Analysis as Topic KW - Agrochemicals -- adverse effects KW - Agriculture KW - Agricultural Workers' Diseases -- etiology KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- epidemiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67244568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Epidemiologic+studies+in+agricultural+populations%3A+observations+and+future+directions.&rft.au=Blair%2C+Aaron%3BFreeman%2C+Laura+Beane&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2009-01-01&rft.volume=14&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1545-0813&rft_id=info:doi/10.1080%2F10599240902779436 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-24 N1 - Date created - 2009-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Scand J Work Environ Health. 1999 Oct;25(5):436-41 [10569464] J Expo Sci Environ Epidemiol. 2009 Sep;19(6):544-54 [19052531] Am J Ind Med. 2001 Nov;40(5):604-11 [11675631] Occup Environ Med. 2003 Sep;60(9):634-42 [12937183] Scand J Work Environ Health. 1992 Aug;18(4):209-15 [1411362] Int Arch Occup Environ Health. 1993;65(3):163-9 [8282414] Am J Ind Med. 1996 May;29(5):501-6 [8732923] Am J Ind Med. 1997 Nov;32(5):510-6 [9327075] Ann Epidemiol. 1998 Jan;8(1):64-74 [9465996] Am J Ind Med. 1998 Sep;34(3):252-60 [9698994] Scand J Work Environ Health. 1998 Aug;24(4):255-61 [9754856] Occup Environ Med. 1999 Jan;56(1):14-21 [10341741] Occup Environ Med. 1999 Aug;56(8):548-52 [10492653] Ann Epidemiol. 2005 Apr;15(4):279-85 [15780775] Am J Epidemiol. 2005 Jun 1;161(11):1037-46 [15901624] Cancer Causes Control. 2005 May;16(4):389-97 [15953981] Scand J Work Environ Health. 2005;31 Suppl 1:9-17; discussion 5-7 [16190144] Scand J Work Environ Health. 2005;31 Suppl 1:39-45; discussion 5-7 [16190148] Ann Occup Hyg. 2007 Jan;51(1):53-65 [16984946] Cancer Causes Control. 2007 Jun;18(5):457-78 [17443416] Am J Ind Med. 2001 Nov;40(5):596-603 [11675630] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10599240902779436 ER - TY - JOUR T1 - Treatment of adolescent depression: what we have come to know. AN - 67222436; 19404989 JF - Depression and anxiety AU - Vitiello, Benedetto AD - Child and Adolescent Treatment and Preventive Interventions Research Branch, National Institute of Mental Health, Room 7147, 6001 Executive Blvd., Bethesda 20892-9633, Maryland, USA. bvitiell@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 393 EP - 395 VL - 26 IS - 5 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Index Medicus KW - Cross-Sectional Studies KW - Randomized Controlled Trials as Topic KW - Suicide, Attempted -- statistics & numerical data KW - Combined Modality Therapy KW - Humans KW - Treatment Outcome KW - Adolescent KW - Fluoxetine -- adverse effects KW - Depressive Disorder, Major -- diagnosis KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Antidepressive Agents, Second-Generation -- therapeutic use KW - Cognitive Therapy KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depressive Disorder, Major -- psychology KW - Fluoxetine -- therapeutic use KW - Depressive Disorder, Major -- therapy KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67222436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Depression+and+anxiety&rft.atitle=Treatment+of+adolescent+depression%3A+what+we+have+come+to+know.&rft.au=Vitiello%2C+Benedetto&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2009-01-01&rft.volume=26&rft.issue=5&rft.spage=393&rft.isbn=&rft.btitle=&rft.title=Depression+and+anxiety&rft.issn=1520-6394&rft_id=info:doi/10.1002%2Fda.20572 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-22 N1 - Date created - 2009-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/da.20572 ER - TY - JOUR T1 - What do we know about the role of gliotoxin in the pathobiology of Aspergillus fumigatus? AN - 67142003; 18608908 AB - Gliotoxin is a member of the epipolythiodioxopiperazine class of toxins and is both the major and the most potent toxin produced by Aspergillus fumigatus. Since the discovery of the putative gliotoxin biosynthetic 12-gene cluster in the genome of A. fumigatus, five different laboratories have attempted to determine the role of this toxin in the virulence of A. fumigatus. The genes in the cluster that have been disrupted to study the pathobiological importance of gliotoxin include gliZ that encodes a transcription factor and gliP that encodes a nonribosomal peptide synthase. Two of the five laboratories have reported gliotoxin to be an important virulence determinant of A. fumigatus, while the other three laboratories have shown it to be unimportant. Comparisons of the data generated among the five laboratories revealed that the immunosuppressive regimen used for mice was the key factor that contributed to the observed disparity. Regardless of either the mouse strains used or the route of infection, immunosuppression with a combination of cyclophosphamide and corticosteroids (neutropenic mice) showed gliotoxin to be unimportant. The mice immunosuppressed with corticosteroids alone, however, revealed that gliotoxin is an important virulence determinant of A. fumigatus. These studies indicate that the neutropenic mice model is inadequate to reveal the pathobiological importance of fungal secondary metabolites in invasive pulmonary aspergillosis. JF - Medical mycology AU - Kwon-Chung, Kyung J AU - Sugui, Janyce A AD - Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. june_kwon-chung@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S97 EP - 103 VL - 47 Suppl 1 KW - Virulence Factors KW - 0 KW - Gliotoxin KW - 67-99-2 KW - Index Medicus KW - Gene Knockout Techniques KW - Animals KW - Genes, Fungal KW - Multigene Family KW - Disease Models, Animal KW - Mice KW - Immunocompromised Host KW - Aspergillus fumigatus -- pathogenicity KW - Virulence Factors -- toxicity KW - Aspergillus fumigatus -- genetics KW - Virulence Factors -- genetics KW - Gliotoxin -- biosynthesis KW - Gliotoxin -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67142003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Immunology&rft.atitle=Antibody-mediated+immunity+to+the+obligate+intracellular+bacterial+pathogen+Coxiella+burnetii+is+Fc+receptor-+and+complement-independent&rft.au=Shannon%2C+Jeffrey+G%3BCockrell%2C+Diane+C%3BTakahashi%2C+Kazue%3BStahl%2C+Gregory+L%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2009-01-01&rft.volume=10&rft.issue=&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=BMC+Immunology&rft.issn=1471-2172&rft_id=info:doi/10.1186%2F1471-2172-10-26 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-27 N1 - Date created - 2009-04-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bone Marrow Transplant. 2002 Jan;29(1):15-9 [11840139] Microbiol Mol Biol Rev. 2002 Sep;66(3):447-59, table of contents [12208999] Blood. 2002 Dec 15;100(13):4358-66 [12393425] Bone Marrow Transplant. 2002 Dec;30(12):925-9 [12476286] Mycopathologia. 2003;156(2):133-8 [12733634] Infect Immun. 2004 Jun;72(6):3373-82 [15155643] Antimicrob Agents Chemother. 1972 Oct;2(4):261-6 [4670497] Proc Natl Acad Sci U S A. 1984 Jun;81(12):3835-7 [6203127] Int J Immunopharmacol. 1986;8(7):789-97 [2430903] J Biol Chem. 1988 Dec 5;263(34):18493-9 [2461370] Infect Immun. 1995 Sep;63(9):3266-71 [7543879] J Exp Med. 1996 Apr 1;183(4):1829-40 [8666939] Gen Pharmacol. 1996 Dec;27(8):1311-6 [9304400] Clin Infect Dis. 1999 Feb;28(2):322-30 [10064251] Clin Microbiol Rev. 1999 Apr;12(2):310-50 [10194462] J Bacteriol. 1999 Oct;181(20):6469-77 [10515939] Blood. 2005 Mar 15;105(6):2258-65 [15546954] Microbiology. 2005 Apr;151(Pt 4):1021-32 [15817772] Nat Rev Microbiol. 2005 Jun;3(6):470-8 [15931165] FEMS Microbiol Lett. 2005 Jul 15;248(2):241-8 [15979823] Eukaryot Cell. 2005 Sep;4(9):1574-82 [16151250] J Clin Microbiol. 2005 Dec;43(12):6120-2 [16333108] Acta Pharm. 2005 Dec;55(4):365-75 [16375826] Clin Immunol. 2006 Jan;118(1):108-16 [16213796] Eukaryot Cell. 2006 Jun;5(6):972-80 [16757745] J Cell Biol. 2006 Aug 14;174(4):509-19 [16893972] Mol Microbiol. 2006 Oct;62(1):292-302 [16956378] Infect Immun. 2006 Dec;74(12):6761-8 [17030582] Biochemistry. 2006 Dec 19;45(50):15029-38 [17154540] Biol Lett. 2007 Oct 22;3(5):523-5 [17686752] Eukaryot Cell. 2007 Sep;6(9):1562-9 [17601876] Eukaryot Cell. 2007 Sep;6(9):1552-61 [17630330] J Leukoc Biol. 2007 Oct;82(4):839-48 [17626149] BMC Evol Biol. 2007;7:174 [17897469] J Infect Dis. 2008 Feb 1;197(3):479-86 [18199036] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/13693780802056012 ER - TY - JOUR T1 - Colobronchial fistula: an unusual complication after peritonectomy and hyperthermic intra-peritoneal chemotherapy (HIPEC). AN - 67141389; 19368141 AB - Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an innovative approach to peritoneal carcinomatosis. Due to the complexity of the combined procedure, high rates of potentially life-threatening complications have been reported. This is the first report of colobronchial fistula following CRS and HIPEC. A 70-year-old woman underwent CRS and HIPEC for papillary well-differentiated peritoneal mesothelioma. During the postoperative course, recurrent pneumonia occurred and bacteria of intestinal origin were isolated from expectorated sputum. Water-soluble contrast studies revealed direct communication between the left colon flexure and the bronchial tree. After appropriate medical and supportive therapies, the patient underwent resection of the splenic flexure and immediate anastomosis with complete recovery. Colobronchial fistula is a rare and potentially lethal complication of CRS and HIPEC. A suggestive clinical picture and contrast studies allow conclusive diagnosis to be made. Surgery is a safe and effective therapeutic option. JF - In vivo (Athens, Greece) AU - Laterza, Barbara AU - Baratti, Dario AU - Cozzi, Guido AU - Kusamura, Shigeki AU - Oliva, Grazia Daniela AU - Gavazzi, Cecilia AU - Fumagalli, Luca AU - Sironi, Alessandro AU - Sabia, Domenico AU - Deraco, Marcello AD - Department of Surgery, National Cancer Institute, Milan, Italy. PY - 2009 SP - 151 EP - 153 VL - 23 IS - 1 SN - 0258-851X, 0258-851X KW - Index Medicus KW - Colon KW - Combined Modality Therapy KW - Peritoneum -- surgery KW - Humans KW - Treatment Outcome KW - Aged KW - Radiography KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Female KW - Mesothelioma -- therapy KW - Intestinal Fistula -- diagnostic imaging KW - Peritoneal Neoplasms -- pathology KW - Hyperthermia, Induced -- adverse effects KW - Mesothelioma -- pathology KW - Bronchial Fistula -- surgery KW - Postoperative Complications -- pathology KW - Postoperative Complications -- etiology KW - Intestinal Fistula -- surgery KW - Intestinal Fistula -- etiology KW - Bronchial Fistula -- etiology KW - Peritoneal Neoplasms -- therapy KW - Bronchial Fistula -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67141389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Colobronchial+fistula%3A+an+unusual+complication+after+peritonectomy+and+hyperthermic+intra-peritoneal+chemotherapy+%28HIPEC%29.&rft.au=Laterza%2C+Barbara%3BBaratti%2C+Dario%3BCozzi%2C+Guido%3BKusamura%2C+Shigeki%3BOliva%2C+Grazia+Daniela%3BGavazzi%2C+Cecilia%3BFumagalli%2C+Luca%3BSironi%2C+Alessandro%3BSabia%2C+Domenico%3BDeraco%2C+Marcello&rft.aulast=Laterza&rft.aufirst=Barbara&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-05 N1 - Date created - 2009-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies. AN - 67118532; 19344187 AB - Immunotoxins are molecules that contain a protein toxin and a ligand that is either an antibody or a growth factor. The ligand binds to a target cell antigen, and the target cell internalizes the immunotoxin, allowing the toxin to migrate to the cytoplasm where it can kill the cell. In the case of recombinant immunotoxins, the ligand and toxin are encoded in DNA that is then expressed in bacteria, and the purified immunotoxin contains the ligand and toxin fused together. Among the most active recombinant immunotoxins clinically tested are those that are targeted to hematologic malignancies. One agent, containing human interleukin-2 and truncated diphtheria toxin (denileukin diftitox), has been approved for use in cutaneous T-cell lymphoma, and has shown activity in other hematologic malignancies, including leukemias and lymphomas. Diphtheria toxin has also been targeted by other ligands, including granulocyte-macrophage colony-stimulating factor and interleukin-3, to target myelogenous leukemia cells. Single-chain antibodies containing variable heavy and light antibody domains have been fused to truncated Pseudomonas exotoxin to target lymphomas and lymphocytic leukemias. Recombinant immunotoxins anti-Tac(Fv)-PE38 (LMB-2), targeting CD25, and RFB4(dsFv)-PE38 (BL22, CAT-3888), targeting CD22, have each been tested in patients. Major responses have been observed after failure of standard chemotherapy. The most successful application of recombinant immunotoxins today is in hairy cell leukemia, where BL22 has induced complete remissions in most patients who were previously treated with optimal chemotherapy. JF - BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy AU - Kreitman, Robert J AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. kreitmar@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1 EP - 13 VL - 23 IS - 1 KW - Antibodies KW - 0 KW - Antibodies, Monoclonal KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Bacterial Toxins KW - Diphtheria Toxin KW - Enterotoxins KW - Exotoxins KW - Immunotoxins KW - Interleukin-2 KW - RFB4(dsFv)-PE38 recombinant immunotoxin KW - Recombinant Fusion Proteins KW - denileukin diftitox KW - 25E79B5CTM KW - Index Medicus KW - Animals KW - Antibodies -- therapeutic use KW - Interleukin-2 -- therapeutic use KW - Humans KW - Treatment Outcome KW - Enterotoxins -- therapeutic use KW - Diphtheria Toxin -- therapeutic use KW - Exotoxins -- therapeutic use KW - Recombinant Fusion Proteins -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use KW - Hematologic Neoplasms -- therapy KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- adverse effects KW - Immunotoxins -- adverse effects KW - Bacterial Toxins -- therapeutic use KW - Immunotoxins -- therapeutic use KW - Hematologic Neoplasms -- immunology KW - Immunotoxins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67118532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.atitle=Recombinant+immunotoxins+containing+truncated+bacterial+toxins+for+the+treatment+of+hematologic+malignancies.&rft.au=Kreitman%2C+Robert+J&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=BioDrugs+%3A+clinical+immunotherapeutics%2C+biopharmaceuticals+and+gene+therapy&rft.issn=1179-190X&rft_id=info:doi/10.2165%2F00063030-200923010-00001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-04 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Jpn J Cancer Res. 1990 Sep;81(9):902-8 [2121691] J Biol Chem. 1990 Nov 25;265(33):20673-7 [2243114] Proc Natl Acad 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Lymphoma. 2002 Apr;43(4):885-8 [12153180] Leukemia. 2003 Jan;17(1):155-9 [12529673] Traffic. 2006 Apr;7(4):379-93 [16536737] Ann Intern Med. 1997 Jun 1;126(11):882-5 [9163289] Leuk Lymphoma. 1997 Apr;25(3-4):381-5 [9168448] Toxicol Lett. 1997 Apr 28;91(2):121-7 [9175848] Biochem Soc Trans. 1997 May;25(2):709-14 [9191188] Blood. 1997 Jul 1;90(1):252-9 [9207460] Eur J Immunol. 1997 Jun;27(6):1459-68 [9209499] Blood. 1997 Sep 1;90(5):2020-6 [9292538] J Biol Chem. 1997 Sep 26;272(39):24165-9 [9305866] Biochemistry. 1997 Nov 25;36(47):14577-82 [9398176] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2165/00063030-200923010-00001 ER - TY - JOUR T1 - Development of a cell-based assay to quantify the inflammatory potential of test substances and screen compound libraries for anti-cancer drug candidates in a high-throughput format. AN - 67118168; 19347277 AB - Despite the current availability of an impressive in vitro assay battery developed to quantitatively analyze the broad panel of small compounds and macromolecules that possess the inflammatory potential, little methodology exists nowadays that affords a researcher or clinician to quantify the ultimate output on the level of cell signaling response caused by inflammatory pathway stimulation. As a matter of fact, majority of analytical tools measure bona fide inflammatory substances (e.g., cytokines or chemokines) by their direct binding to secondary reagents such as specific antibodies or other selectively affine substrates with the final readout generated via quantification of the resulting complexes. Although specific and highly reproducible, this approach provides no discrimination between biologically active versus inactive input analyte nor does it address the differential biological potential for the questioned substances related to their in vivo stability and biodistribution. In a search for alternative solutions, a novel strategy is emerging that employs cell-based methods of inflammatory substance measurements allowing to detect and quantify the downstream effects of analyte's activity translated in terms of inflammatory pathways stimulation. In addition, application of cell based assays simultaneously permits entry level evaluation of compound toxicity and endows with a powerful approach to perform high-throughput screenings of, e.g., small molecule libraries in a quest for novel compounds capable of influencing the inflammation process. JF - Methods in molecular biology (Clifton, N.J.) AU - Kozlov, Serguei V AD - Cancer and Developmental Biology Laboratory, National Cancer Institute at Frederick, Frederick, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 159 EP - 167 VL - 512 SN - 1064-3745, 1064-3745 KW - Anti-Inflammatory Agents KW - 0 KW - Antineoplastic Agents KW - Pharmaceutical Preparations KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - HeLa Cells KW - Humans KW - Drug Screening Assays, Antitumor KW - Anti-Inflammatory Agents -- analysis KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Inflammation -- chemically induced KW - Tumor Necrosis Factor-alpha -- analysis KW - Antineoplastic Agents -- pharmacology KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67118168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Development+of+a+cell-based+assay+to+quantify+the+inflammatory+potential+of+test+substances+and+screen+compound+libraries+for+anti-cancer+drug+candidates+in+a+high-throughput+format.&rft.au=Kozlov%2C+Serguei+V&rft.aulast=Kozlov&rft.aufirst=Serguei&rft.date=2009-01-01&rft.volume=512&rft.issue=&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-60327-530-9_9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-530-9_9 ER - TY - JOUR T1 - Collection and preparation of rodent tissue samples for histopathological and molecular studies in carcinogenesis. AN - 67112480; 19347291 AB - Histology, as a mean of tissue visualization on a cellular level, is a fundamental tool in the study of cancer. The need for simultaneous delivery of quality histological material for pathological evaluation and subsequent genomic and proteomic studies, however, requires modification of traditional practices to include rapid isolation and stabilization of target tissue to preserve molecular integrity. Informative molecular analysis depends on the integrity of target molecules (RNA, DNA, and proteins) in the tissue during and after its collection. A reliable systematic approach to routine and genomic/proteomic sample collection and preparation presented is supported by detailed protocols. JF - Methods in molecular biology (Clifton, N.J.) AU - Golubeva, Yelena AU - Rogers, Keith AD - Histotechnology Laboratory, NCI-Frederick, SAIC-Frederick, Frederick, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 3 EP - 60 VL - 511 SN - 1064-3745, 1064-3745 KW - RNA, Neoplasm KW - 0 KW - Index Medicus KW - Biological Assay -- methods KW - Animals KW - Microdissection -- methods KW - Genomics -- methods KW - Microdissection -- instrumentation KW - Humans KW - RNA Stability KW - Biological Assay -- instrumentation KW - Mice KW - Lasers KW - RNA, Neoplasm -- analysis KW - Female KW - Histocytochemistry -- methods KW - Neoplasms -- pathology KW - Tissue Fixation -- methods KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67112480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Collection+and+preparation+of+rodent+tissue+samples+for+histopathological+and+molecular+studies+in+carcinogenesis.&rft.au=Golubeva%2C+Yelena%3BRogers%2C+Keith&rft.aulast=Golubeva&rft.aufirst=Yelena&rft.date=2009-01-01&rft.volume=511&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-447-6_1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-18 N1 - Date created - 2009-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-447-6_1 ER - TY - JOUR T1 - A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. AN - 67086948; 19330036 AB - K-Ras mutations are characteristic of human lung adenocarcinomas and occur almost exclusively in smokers. In preclinical models, K-Ras mutations are necessary for tobacco carcinogen-driven lung tumorigenesis and are sufficient to cause lung adenocarcinomas in transgenic mice. Because these mutations confer resistance to commonly used cytotoxic chemotherapies and targeted agents, effective therapies that target K-Ras are needed. Inhibitors of mTOR such as rapamycin can prevent K-Ras-driven lung tumorigenesis and alter the proportion of cytotoxic and Foxp3+ regulatory T cells, suggesting that lung-associated T cells might be important for tumorigenesis. Lung tumorigenesis was studied in three murine models that depend on mutant K-Ras; a tobacco carcinogen-driven model, a syngeneic inoculation model, and a transgenic model. Splenic and lung-associated T cells were studied using flow cytometry and immunohistochemistry. Foxp3+ cells were depleted using rapamycin, an antibody, or genetic ablation. Exposure of A/J mice to a tobacco carcinogen tripled lung-associated Foxp3+ cells prior to tumor development. At clinically relevant concentrations, rapamycin prevented this induction and reduced lung tumors by 90%. In A/J mice inoculated with lung adenocarcinoma cells resistant to rapamycin, antibody-mediated depletion of Foxp3+ cells reduced lung tumorigenesis by 80%. Likewise, mutant K-Ras transgenic mice lacking Foxp3+ cells developed 75% fewer lung tumors than littermates with Foxp3+ cells. Foxp3+ regulatory T cells are required for K-Ras-mediated lung tumorigenesis in mice. These studies support clinical testing of rapamycin or other agents that target Treg in K-Ras driven human lung cancer. JF - PloS one AU - Granville, Courtney A AU - Memmott, Regan M AU - Balogh, Andria AU - Mariotti, Jacopo AU - Kawabata, Shigeru AU - Han, Wei AU - Lopiccolo, Jaclyn AU - Foley, Jason AU - Liewehr, David J AU - Steinberg, Seth M AU - Fowler, Daniel H AU - Hollander, M Christine AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 1 VL - 4 IS - 3 KW - Forkhead Transcription Factors KW - 0 KW - Foxp3 protein, mouse KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Animals KW - Sirolimus -- pharmacology KW - Tobacco KW - Disease Models, Animal KW - Mice KW - Mice, Transgenic KW - Lung Neoplasms -- etiology KW - T-Lymphocytes, Regulatory -- drug effects KW - Genes, ras -- genetics KW - T-Lymphocytes, Regulatory -- pathology KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67086948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=A+central+role+for+Foxp3%2B+regulatory+T+cells+in+K-Ras-driven+lung+tumorigenesis.&rft.au=Granville%2C+Courtney+A%3BMemmott%2C+Regan+M%3BBalogh%2C+Andria%3BMariotti%2C+Jacopo%3BKawabata%2C+Shigeru%3BHan%2C+Wei%3BLopiccolo%2C+Jaclyn%3BFoley%2C+Jason%3BLiewehr%2C+David+J%3BSteinberg%2C+Seth+M%3BFowler%2C+Daniel+H%3BHollander%2C+M+Christine%3BDennis%2C+Phillip+A&rft.aulast=Granville&rft.aufirst=Courtney&rft.date=2009-01-01&rft.volume=4&rft.issue=3&rft.spage=e5061&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0005061 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-27 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2008 Apr 15;180(8):5163-6 [18390696] J Clin Oncol. 2008 Apr 1;26(10):1588-95 [18332470] J Transl Med. 2008;6:19 [18430198] Curr Opin Immunol. 2008 Apr;20(2):241-6 [18508251] J Immunol. 2008 Aug 1;181(3):2220-6 [18641362] J Oral Pathol Med. 2008 Sep;37(8):485-9 [18355177] Nat Genet. 2001 Jan;27(1):18-20 [11137992] Nat Genet. 2001 Jan;27(1):68-73 [11138001] J Clin Invest. 2003 Jan;111(1):81-90 [12511591] Science. 2003 Feb 14;299(5609):1057-61 [12522256] Carcinogenesis. 2004 Apr;25(4):623-9 [14656941] Chest. 2004 Apr;125(4):1467-71 [15078760] Nat Med. 2004 Jun;10(6):594-601 [15156201] Nat Med. 2004 Sep;10(9):942-9 [15322536] Ann Intern Med. 1986 Oct;105(4):503-7 [3752756] Cancer Res. 1992 Jun 1;52(11):3164-73 [1591728] Cancer. 1993 Jul 15;72(2):432-8 [8319174] Cancer Res. 1995 Apr 1;55(7):1444-7 [7882350] J Immunol. 1995 Aug 1;155(3):1151-64 [7636184] Cancer Res. 1996 May 1;56(9):2224-8 [8616876] Cancer Res. 1998 Dec 1;58(23):5354-60 [9850065] Cancer Res. 2005 Apr 15;65(8):3226-35 [15833854] Cancer Res. 2005 Jun 15;65(12):5211-20 [15958566] Cancer Res. 2005 Jun 15;65(12):5325-36 [15958580] Nat Rev Immunol. 2006 Apr;6(4):295-307 [16557261] Oncol Rep. 2006 May;15(5):1315-9 [16596204] Am J Respir Cell Mol Biol. 2007 Jan;36(1):13-9 [16873770] Cancer. 2006 Dec 15;107(12):2866-72 [17099880] Clin Cancer Res. 2007 Apr 1;13(7):2281-9 [17404113] Chest. 2007 Jul;132(1):156-63 [17505034] J Clin Oncol. 2008 Jan 20;26(3):361-7 [18202410] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Cancer Res. 2008 Apr 15;68(8):3001-9 [18413770] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1371/journal.pone.0005061 ER - TY - JOUR T1 - Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. AN - 67085603; 19288225 AB - Neurons require large amounts of energy to support their survival and function, and are therefore susceptible to excitotoxicity, a form of cell death involving bioenergetic stress that may occur in several neurological disorders including stroke and Alzheimer's disease. Here we studied the roles of NAD(+) bioenergetic state, and the NAD(+)-dependent enzymes SIRT1 and PARP-1, in excitotoxic neuronal death in cultured neurons and in a mouse model of focal ischemic stroke. Excitotoxic activation of NMDA receptors induced a rapid decrease of cellular NAD(P)H levels and mitochondrial membrane potential. Decreased NAD(+) levels and poly (ADP-ribose) polymer (PAR) accumulation in nuclei were relatively early events (<4 h) that preceded the appearance of propidium iodide- and TUNEL-positive cells (markers of necrotic cell death and DNA strand breakage, respectively) which became evident by 6 h. Nicotinamide, an NAD(+) precursor and an inhibitor of SIRT1 and PARP1, inhibited SIRT1 deacetylase activity without affecting SIRT1 protein levels. NAD(+) levels were preserved and PAR accumulation and neuronal death induced by excitotoxic insults were attenuated in nicotinamide-treated cells. Treatment of neurons with the SIRT1 activator resveratrol did not protect them from glutamate/NMDA-induced NAD(+) depletion and death. In a mouse model of focal cerebral ischemic stroke, NAD(+) levels were decreased in both the contralateral and ipsilateral cortex 6 h after the onset of ischemia. Stroke resulted in dynamic changes of SIRT1 protein and activity levels which varied among brain regions. Administration of nicotinamide (200 mg/kg, i.p.) up to 1 h after the onset of ischemia elevated brain NAD(+) levels and reduced ischemic infarct size. Our findings demonstrate that the NAD(+) bioenergetic state is critical in determining whether neurons live or die in excitotoxic and ischemic conditions, and suggest a potential therapeutic benefit in stroke of agents that preserve cellular NAD(+) levels. Our data further suggest that, SIRT1 is linked to bioenergetic state and stress responses in neurons, and that under conditions of reduced cellular energy levels SIRT1 enzyme activity may consume sufficient NAD(+) to nullify any cell survival-promoting effects of its deacetylase action on protein substrates. JF - Neuromolecular medicine AU - Liu, Dong AU - Gharavi, Robert AU - Pitta, Michael AU - Gleichmann, Marc AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA. liudo@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 28 EP - 42 VL - 11 IS - 1 KW - Antioxidants KW - 0 KW - Neuroprotective Agents KW - Neurotoxins KW - Receptors, Glutamate KW - Stilbenes KW - NAD KW - 0U46U6E8UK KW - Niacinamide KW - 25X51I8RD4 KW - Sirt1 protein, mouse KW - EC 3.5.1.- KW - Sirtuin 1 KW - Sirtuins KW - resveratrol KW - Q369O8926L KW - Index Medicus KW - Rats KW - Cell Death -- physiology KW - Animals KW - Rats, Sprague-Dawley KW - Antioxidants -- metabolism KW - Neurotoxins -- metabolism KW - Cells, Cultured KW - Receptors, Glutamate -- metabolism KW - Mice, Inbred C57BL KW - Mice KW - Stilbenes -- metabolism KW - Male KW - NAD -- metabolism KW - Sirtuins -- metabolism KW - Neurons -- metabolism KW - Brain Ischemia -- prevention & control KW - Neurons -- cytology KW - Neuroprotective Agents -- metabolism KW - Brain Ischemia -- metabolism KW - Niacinamide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67085603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuromolecular+medicine&rft.atitle=Nicotinamide+prevents+NAD%2B+depletion+and+protects+neurons+against+excitotoxicity+and+cerebral+ischemia%3A+NAD%2B+consumption+by+SIRT1+may+endanger+energetically+compromised+neurons.&rft.au=Liu%2C+Dong%3BGharavi%2C+Robert%3BPitta%2C+Michael%3BGleichmann%2C+Marc%3BMattson%2C+Mark+P&rft.aulast=Liu&rft.aufirst=Dong&rft.date=2009-01-01&rft.volume=11&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Neuromolecular+medicine&rft.issn=1559-1174&rft_id=info:doi/10.1007%2Fs12017-009-8058-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-24 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cereb Blood Flow Metab. 1992 May;12(3):371-9 [1314840] FASEB J. 1992 Dec;6(15):3338-44 [1464368] Cancer Res. 1993 Sep 1;53(17):3976-85 [8358726] Exp Neurol. 1995 Apr;132(2):279-83 [7789466] Methods Cell Biol. 1995;46:187-216 [7541884] Neuron. 1995 Oct;15(4):961-73 [7576644] Neurosurgery. 1996 Jun;38(6):1216-22 [8727154] Prog Neurobiol. 1996 Apr;48(6):613-34 [8809910] J Neurosci. 1998 Jan 1;18(1):156-63 [9412496] J Nutr. 2002 Jul;132(7):2076-81 [12097696] J Biol Chem. 1999 Aug 13;274(33):22932-40 [10438458] Mol Cell. 2005 Feb 18;17(4):595-601 [15721262] Curr Drug Targets CNS Neurol Disord. 2005 Feb;4(1):41-50 [15723612] Nature. 2005 Mar 3;434(7029):113-8 [15744310] Int J Mol Med. 2005 Aug;16(2):237-43 [16012755] FEBS J. 2005 Sep;272(18):4607-16 [16156783] Cell. 2005 Nov 18;123(4):655-67 [16286010] J Biol Chem. 2005 Dec 30;280(52):43121-30 [16207712] Brain Res Bull. 2006 Mar 31;69(2):117-22 [16533659] Annu Rev Neurosci. 1998;21:347-75 [9530500] Blood. 1998 Aug 1;92(3):996-1002 [9680369] Exp Neurol. 1999 May;157(1):142-9 [10222117] Brain Res Mol Brain Res. 1999 May 7;68(1-2):29-41 [10320781] Mol Cell Biol. 1999 Jul;19(7):5124-33 [10373561] J Cereb Blood Flow Metab. 2000 Feb;20(2):306-15 [10698068] J Neurosci. 2000 May 1;20(9):3139-46 [10777777] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5807-11 [10811920] Neurobiol Dis. 2000 Aug;7(4):225-39 [10964595] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14178-82 [11106374] Ann Neurol. 2001 May;49(5):561-74 [11357946] J Biol Chem. 2001 Jan 26;276(4):2571-5 [11073947] J Cereb Blood Flow Metab. 2002 Apr;22(4):431-43 [11919514] Cell Cycle. 2006 Apr;5(8):873-7 [16628003] Neuromolecular Med. 2006;8(3):389-414 [16775390] J Cereb Blood Flow Metab. 2006 Sep;26(9):1141-7 [16395277] Nat Rev Neurosci. 2006 Oct;7(10):784-96 [16988654] FEBS Lett. 2006 Oct 30;580(25):5875-9 [17027980] J Cereb Blood Flow Metab. 2006 Nov;26(11):1389-406 [16538234] Eur J Neurosci. 2006 Oct;24(8):2169-76 [17042794] Trends Biochem Sci. 2007 Jan;32(1):12-9 [17161604] AAPS J. 2006;8(4):E632-43 [17233528] J Neurochem. 2007 Mar;100(5):1364-74 [17250676] Neuroscience. 2007 Apr 14;145(4):1267-72 [17084037] Circ Res. 2007 May 25;100(10):1512-21 [17446436] J Neurosci Res. 2007 Nov 15;85(15):3407-15 [17847081] J Neurosci. 2008 Nov 5;28(45):11500-10 [18987186] Ann N Y Acad Sci. 2008 Dec;1147:275-82 [19076449] J Clin Invest. 2000 Sep;106(6):723-31 [10995780] Ann Neurol. 2000 Nov;48(5):723-9 [11079535] Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1845-50 [10677544] Nature. 2000 Feb 17;403(6771):795-800 [10693811] Pharmacol Biochem Behav. 2002 Nov;73(4):901-10 [12213537] Pharmacol Rev. 2002 Sep;54(3):375-429 [12223530] Neuromolecular Med. 2002;2(2):215-31 [12428812] J Biol Chem. 2002 Nov 22;277(47):45099-107 [12297502] Mol Cell Biol. 2003 Jan;23(1):38-54 [12482959] Neuromolecular Med. 2003;3(2):65-94 [12728191] J Biol Chem. 2003 May 16;278(20):18426-33 [12626504] Neurochem Res. 2003 Aug;28(8):1227-34 [12834263] Fortschr Neurol Psychiatr. 2003 Jul;71 Suppl 1:S10-5 [12947538] Nature. 2003 Sep 11;425(6954):191-6 [12939617] Pharmacology. 2003 Nov;69(3):150-7 [14512702] Science. 2003 Dec 19;302(5653):2124-6 [14605207] Science. 2004 Mar 26;303(5666):2011-5 [14976264] Cell. 2004 May 14;117(4):495-502 [15137942] Annu Rev Biochem. 2004;73:417-35 [15189148] Science. 2004 Jul 16;305(5682):390-2 [15205477] Science. 2004 Aug 13;305(5686):1010-3 [15310905] Trends Neurosci. 2004 Sep;27(9):555-60 [15331238] J Biol Chem. 2004 Sep 17;279(38):40122-9 [15269219] J Bioenerg Biomembr. 2004 Aug;36(4):287-94 [15377859] Anal Biochem. 1971 Oct;43(2):341-8 [4400964] Biophys J. 1989 Apr;55(4):621-30 [2720061] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12017-009-8058-1 ER - TY - JOUR T1 - Capecitabine and celecoxib as second-line treatment of advanced pancreatic and biliary tract cancers. AN - 67079552; 19246950 AB - An increasing number of patients with advanced pancreatic or biliary tract cancer who progress after a gemcitabine-containing regimen are candidates for further chemotherapy. We therefore evaluated a fully oral regimen of capecitabine and celecoxib (CapCel) as second-line treatment in these patients. Thirty-five patients with documented progressive disease after first-line treatment were enrolled. Capecitabine was administered at a dose of 1,000 mg/m(2) b.i.d. for 2 consecutive weeks followed by 1 week of rest; celecoxib was given continuously at 200 mg b.i.d. Progression-free survival at 3 months was the primary study endpoint. The CapCel combination was associated with an overall response rate of 9% and median survival duration of 19 weeks. Sixty percent of patients were free from progression 3 months after the start of treatment. Multivariate analysis identified a positive clinical benefit response and a decline in CA 19.9 serum levels >25% compared with baseline levels as independent predictors of prolonged survival. The treatment protocol was well tolerated with negligible hematological toxicity. The most common grade 3 non-hematological toxicities were hypertransaminasemia, diarrhea and asthenia. The CapCel combination is a safe treatment option with moderate activity in patients with pancreatic/biliary tract cancer after failure of a previous gemcitabine-containing regimen. Copyright 2009 S. Karger AG, Basel. JF - Oncology AU - Pino, Maria S AU - Milella, Michele AU - Gelibter, Alain AU - Sperduti, Isabella AU - De Marco, Salvatore AU - Nuzzo, Carmen AU - Bria, Emilio AU - Carpanese, Livio AU - Ruggeri, Enzo M AU - Carlini, Paolo AU - Cognetti, Francesco AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. Y1 - 2009 PY - 2009 DA - 2009 SP - 254 EP - 261 VL - 76 IS - 4 KW - Pyrazoles KW - 0 KW - Sulfonamides KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - Celecoxib KW - JCX84Q7J1L KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Prospective Studies KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Pyrazoles -- administration & dosage KW - Pancreatic Neoplasms -- mortality KW - Carcinoma, Pancreatic Ductal -- drug therapy KW - Carcinoma, Pancreatic Ductal -- mortality KW - Deoxycytidine -- analogs & derivatives KW - Adenocarcinoma -- mortality KW - Pyrazoles -- adverse effects KW - Sulfonamides -- administration & dosage KW - Biliary Tract Neoplasms -- drug therapy KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - Sulfonamides -- adverse effects KW - Deoxycytidine -- adverse effects KW - Fluorouracil -- analogs & derivatives KW - Deoxycytidine -- administration & dosage KW - Pancreatic Neoplasms -- drug therapy KW - Biliary Tract Neoplasms -- mortality KW - Adenocarcinoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67079552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology&rft.atitle=Capecitabine+and+celecoxib+as+second-line+treatment+of+advanced+pancreatic+and+biliary+tract+cancers.&rft.au=Pino%2C+Maria+S%3BMilella%2C+Michele%3BGelibter%2C+Alain%3BSperduti%2C+Isabella%3BDe+Marco%2C+Salvatore%3BNuzzo%2C+Carmen%3BBria%2C+Emilio%3BCarpanese%2C+Livio%3BRuggeri%2C+Enzo+M%3BCarlini%2C+Paolo%3BCognetti%2C+Francesco&rft.aulast=Pino&rft.aufirst=Maria&rft.date=2009-01-01&rft.volume=76&rft.issue=4&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Oncology&rft.issn=1423-0232&rft_id=info:doi/10.1159%2F000205388 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000205388 ER - TY - JOUR T1 - PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells. AN - 67047488; 19305641 AB - Cytoplasmic expression of claudin-1 in metastatic melanoma cells correlates to increased migration, and increased secretion of MMP-2 in a PKC dependent manner, whereas claudin-1 nuclear expression is found in benign nevi. Melanoma cells were transfected with a vector expressing CLDN-1 fused to a nuclear localization signal (NLS). Despite significant nuclear localization of claudin-1, there was still transport of claudin-1 to the cytoplasm. Phorbol ester treatment of cells transfected with NLS-claudin-1 resulted in an exclusion of claudin-1 from the nucleus, despite the NLS. To ascertain whether PKC or PKA were involved in this translocation, we mutated the putative phosphorylation sites within the protein. We found that mutating the PKC phosphorylation sites to mimic a non-phosphorylated state did not cause a shift of claudin-1 to the nucleus of the cells, but mutating the PKA sites did. Mutations of either site to mimic constitutive phosphorylation resulted in cytoplasmic claudin-1 expression. Stable claudin-1 transfectants containing non-phosphorylatable PKA sites exhibited decreased motility. These data imply that subcellular localization of claudin-1 can be controlled by phosphorylation, dicating effects on metastatic capacity. JF - International journal of medical sciences AU - French, Amanda D AU - Fiori, Jennifer L AU - Camilli, Tura C AU - Leotlela, Poloko D AU - O'Connell, Michael P AU - Frank, Brittany P AU - Subaran, Sarah AU - Indig, Fred E AU - Taub, Dennis D AU - Weeraratna, Ashani T AD - Laboratory of Immunology, National Institute on Aging, Baltimore, MD 21124, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 93 EP - 101 VL - 6 IS - 2 KW - CLDN1 protein, human KW - 0 KW - Claudin-1 KW - Membrane Proteins KW - Nuclear Localization Signals KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - PKA KW - metastasis KW - Claudin KW - melanoma KW - PKC KW - Neoplasm Invasiveness KW - Computer Simulation KW - Cell Nucleus -- metabolism KW - Enzyme Activation KW - Humans KW - Biological Transport -- genetics KW - Cell Line, Tumor KW - Cell Nucleus -- drug effects KW - Nuclear Localization Signals -- metabolism KW - Matrix Metalloproteinase 2 -- metabolism KW - Mutagenesis, Site-Directed KW - Phosphorylation KW - Cytoplasm -- genetics KW - Transfection KW - Cytoplasm -- metabolism KW - Genetic Vectors KW - Neoplasm Metastasis KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Subcellular Fractions -- metabolism KW - Nuclear Localization Signals -- genetics KW - Immunohistochemistry KW - Cell Nucleus -- genetics KW - Protein Kinase C -- metabolism KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Melanoma -- pathology KW - Membrane Proteins -- metabolism KW - Melanoma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67047488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+medical+sciences&rft.atitle=PKC+and+PKA+phosphorylation+affect+the+subcellular+localization+of+claudin-1+in+melanoma+cells.&rft.au=French%2C+Amanda+D%3BFiori%2C+Jennifer+L%3BCamilli%2C+Tura+C%3BLeotlela%2C+Poloko+D%3BO%27Connell%2C+Michael+P%3BFrank%2C+Brittany+P%3BSubaran%2C+Sarah%3BIndig%2C+Fred+E%3BTaub%2C+Dennis+D%3BWeeraratna%2C+Ashani+T&rft.aulast=French&rft.aufirst=Amanda&rft.date=2009-01-01&rft.volume=6&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=International+journal+of+medical+sciences&rft.issn=1449-1907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-07 N1 - Date created - 2009-03-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroreport. 2000 May 15;11(7):1427-31 [10841351] Methods Mol Biol. 2008;468:243-53 [19099260] Traffic. 2001 Feb;2(2):93-8 [11247307] J Cell Biol. 2002 Mar 18;156(6):1099-111 [11889141] Oncol Res. 2001;12(11-12):469-76 [11939410] Cancer Cell. 2002 Apr;1(3):279-88 [12086864] J Biol Chem. 2003 Jan 24;278(4):2692-700 [12403786] Am J Physiol Cell Physiol. 2003 Aug;285(2):C300-9 [12660149] J Biol Chem. 2004 Aug 20;279(34):35702-8 [15187091] Am J Pathol. 2005 May;166(5):1541-54 [15855653] J Biol Chem. 2005 Jul 15;280(28):26233-40 [15905176] J Clin Invest. 2005 Jul;115(7):1765-76 [15965503] Cancer Res. 2005 Nov 1;65(21):9603-6 [16266975] Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H381-9 [16155104] Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):287-91 [16831296] Oncogene. 2007 May 31;26(26):3846-56 [17160014] J Biol Chem. 2007 Jun 8;282(23):17259-71 [17426020] Mol Pharmacol. 2008 Aug;74(2):432-42 [18477669] PLoS One. 2008;3(7):e2715 [18648642] Cancer Res. 2008 Dec 15;68(24):10205-14 [19074888] Cancer Res. 2000 Nov 15;60(22):6281-7 [11103784] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - EEG and cerebral blood flow velocity abnormalities in chronic cocaine users. AN - 67016958; 19278131 AB - EEG and cerebral blood flow abnormalities have been documented in chronic cocaine abusers. To identify possible relationships between EEG and blood flow changes and their relationship to the intensity of cocaine use, we recorded the resting eyes-closed EEG and anterior (ACA) and middle (MCA) cerebral artery blood flow velocity during systole (V(S)) and diastole (V(D)) by transcranial Doppler (TCD) sonography of 99 (76 male, 23 female; mean [SD] age 34.3 [5.2] years, 8.6 [5.5] years of cocaine use, 17.8 [7.7] days of cocaine use in month prior to screening) cocaine users within 5 days of admission to a closed research unit. Forty-two non-drug-using, age-matched control subjects (22 male, 20 female) were tested as outpatients. A 3-minute period of resting EEG was recorded from 16 standard scalp electrodes. Artifact-free EEG was converted to six frequency bands (delta, theta, alpha1, alpha2, beta1 and beta2) using a Fast Fourier Transform. Pulsatility index (PI) was calculated as a measure of small vessel resistance. Cocaine users had decreased VD and increased PI in the MCA, with no difference in V(S), and reduced EEG theta, beta1 and beta2 absolute power in posterior brain regions. Recent cocaine use was positively associated with MCA PI (r = 0.27, p < 0.001) and negatively associated with low frequency EEG power (delta power: r = -0.25, p < 0.002; theta power: r = -0.29, p < 0.001). EEG beta1 (r = -0.211, p < 0.05) and beta2 (r = -0.176, p < 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence. JF - Clinical EEG and neuroscience AU - Copersino, Marc L AU - Herning, Ronald I AU - Better, Warren AU - Cadet, Jean-Lud AU - Gorelick, David A AD - Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 39 EP - 42 VL - 40 IS - 1 SN - 1550-0594, 1550-0594 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Analysis of Variance KW - Blood Flow Velocity KW - Humans KW - Adult KW - Ultrasonography, Doppler, Transcranial KW - Cocaine -- toxicity KW - Fourier Analysis KW - Male KW - Female KW - Anterior Cerebral Artery -- drug effects KW - Brain -- blood supply KW - Brain -- drug effects KW - Electroencephalography KW - Anterior Cerebral Artery -- diagnostic imaging KW - Cerebrovascular Circulation KW - Middle Cerebral Artery -- diagnostic imaging KW - Cocaine-Related Disorders -- diagnostic imaging KW - Brain -- physiopathology KW - Middle Cerebral Artery -- physiopathology KW - Middle Cerebral Artery -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Anterior Cerebral Artery -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67016958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+and+neuroscience&rft.atitle=EEG+and+cerebral+blood+flow+velocity+abnormalities+in+chronic+cocaine+users.&rft.au=Copersino%2C+Marc+L%3BHerning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean-Lud%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2009-01-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+and+neuroscience&rft.issn=15500594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-03 N1 - Date created - 2009-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addict Behav. 1994 Nov-Dec;19(6):599-607 [7701971] J Nucl Med. 1995 Jul;36(7):1211-5 [7790946] J Neurosurg. 1996 Jan;84(1):79-84 [8613840] Psychiatry Res. 1995 Oct 16;58(3):247-57 [8570780] Epilepsia. 1996 Sep;37(9):875-8 [8814101] Biol Psychiatry. 1996 Nov 15;40(10):986-93 [8915557] Neurology. 1997 Feb;48(2):341-5 [9040718] Biol Psychiatry. 1997 Jun 1;41(11):1087-94 [9146819] Drug Alcohol Depend. 1997 Jun 6;46(1-2):87-93 [9246556] Neuropsychopharmacology. 1998 Jul;19(1):1-9 [9608571] Biol Psychiatry. 1999 May 1;45(9):1203-11 [10331113] J Neuropsychiatry Clin Neurosci. 1999 Spring;11(2):209-21 [10333992] Neuropsychopharmacology. 1999 Jul;21(1):110-8 [10379525] J Clin Neurophysiol. 2004 Sep-Oct;21(5):341-52 [15592008] Arch Gen Psychiatry. 2007 Apr;64(4):495-502 [17404126] Postgrad Med J. 2007 Jun;83(980):389-94 [17551070] Clin Neurophysiol. 2000 Apr;111(4):604-12 [10727911] Stroke. 2000 May;31(5):1111-5 [10797173] Neuropsychobiology. 2000;42(2):93-8 [10940764] Clin Neurophysiol. 2000 Nov;111(11):1961-7 [11068230] Neuropsychopharmacology. 2001 Sep;25(3):332-40 [11522462] Stroke. 2001 Oct;32(10):2338-43 [11588323] Epilepsia. 2002;43 Suppl 2:28-31 [11903480] Biol Psychiatry. 2002 Oct 15;52(8):831-42 [12372655] J Psychoactive Drugs. 2002 Oct-Dec;34(4):415-9 [12562110] Stroke. 2003 Jun;34(6):1375-81 [12764233] Radiology. 1990 Sep;176(3):821-4 [2389042] Am J Drug Alcohol Abuse. 1990;16(3-4):307-17 [2126913] Headache. 1991 Jan;31(1):17-9 [2016163] J Nucl Med. 1991 Jun;32(6):1206-10 [2045934] Psychiatry Res. 1990 Dec;35(2):95-105 [2100807] J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):803-6 [1955899] J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):419-27 [8286941] J Nucl Med. 1994 Dec;35(12):1902-9 [7989967] Neuropsychobiology. 1994;30(4):189-96 [7862268] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Helicobacter Pylori associated global gastric cancer burden. AN - 67013314; 19273142 AB - Helicobacter pylori infection is ubiquitous, infecting close to one-half of the world's population, but its prevalence is declining in developed countries. Chronic H. pylori infection is etiologically linked to gastric adenocarcinoma, especially non-cardia type (63% of all stomach cancer or ~5.5% of the global cancer burden: ~25% of cancers associated with infectious etiology), and to gastric mucosal associated lymphoid tissue (MALT) lymphoma, which accounts for up to 8% of all non-Hodgkin lymphoma. Epidemiological, clinical, and animal studies have established a central role for H. pylori in gastric carcinogenesis and provided insights into the mechanisms and biologic relationships between bacterial infection, host genetics, nutrition, and environmental factors. These discoveries invite strategies to prevent infection to be the logical primary goals in a multi-pronged effort to curtail suffering and death from H. pylori infection-associated cancers. JF - Frontiers in bioscience (Landmark edition) AU - Mbulaiteye, Sam M AU - Hisada, Michie AU - El-Omar, Emad M AD - Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. mbulaits@mail.nih.gov Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 1490 EP - 1504 VL - 14 KW - Index Medicus KW - Virulence KW - Global Health KW - Risk Factors KW - Humans KW - Incidence KW - Stomach Neoplasms -- microbiology KW - Lymphoma, B-Cell, Marginal Zone -- prevention & control KW - Lymphoma, B-Cell, Marginal Zone -- microbiology KW - Lymphoma, B-Cell, Marginal Zone -- epidemiology KW - Helicobacter pylori -- pathogenicity KW - Stomach Neoplasms -- prevention & control KW - Stomach Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67013314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%28Landmark+edition%29&rft.atitle=Helicobacter+Pylori+associated+global+gastric+cancer+burden.&rft.au=Mbulaiteye%2C+Sam+M%3BHisada%2C+Michie%3BEl-Omar%2C+Emad+M&rft.aulast=Mbulaiteye&rft.aufirst=Sam&rft.date=2009-01-01&rft.volume=14&rft.issue=&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%28Landmark+edition%29&rft.issn=1093-4715&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-03-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Scand J Gastroenterol. 1997 Jan;32(1):28-33 [9018763] Semin Gastrointest Dis. 1997 Jul;8(3):142-55 [9232727] Gastroenterology. 1998 Jun;114(6):1169-79 [9609753] J Infect Dis. 1998 Sep;178(3):717-21 [9728540] Pediatr Res. 1999 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Infect Immun. 2003 Jun;71(6):3496-502 [12761134] IARC Sci Publ. 2002;(155):1-781 [12812229] Cancer Sci. 2003 Mar;94(3):235-9 [12824915] Gastroenterology. 2003 Aug;125(2):364-71 [12891537] Gut. 2003 Dec;52(12):1684-9 [14633943] JAMA. 2004 Jan 14;291(2):187-94 [14722144] Gastroenterology. 2003 Dec;125(6):1636-44 [14724815] Curr Top Med Chem. 2004;4(5):531-8 [14965304] Helicobacter. 2004 Jun;9(3):262-70 [15165263] J Gastroenterol. 2004;39(5):429-33 [15175940] Gastroenterology. 2004 Jul;127(1):73-9 [15236174] Aliment Pharmacol Ther. 2004 Jul;20 Suppl 1:1-6 [15298598] Nat Rev Cancer. 2004 Sep;4(9):688-94 [15343275] Leukemia. 2004 Oct;18(10):1722-6 [15356642] J Infect Dis. 2004 Nov 1;190(9):1605-9 [15478065] Br Med J. 1965 Sep 25;2(5464):719-22 [4283943] East Afr Med J. 1966 Jul;43(7):274-83 [5911333] Lancet. 1984 Jun 16;1(8390):1311-5 [6145023] Med J Aust. 1985 Apr 15;142(8):439-44 [3982346] Epidemiol Rev. 1986;8:1-27 [3533579] Afr J Med Med Sci. 1988 Jun;17(2):89-95 [2843023] Cancer Res. 1990 Aug 1;50(15):4737-40 [2369748] Am J Gastroenterol. 1992 Jan;87(1):28-30 [1728121] Lancet. 1993 Sep 4;342(8871):575-7 [8102719] Gut. 1993 Dec;34(12):1672-6 [8282253] Gastroenterology. 1996 Aug;111(2):426-32 [8690208] Scand J Gastroenterol Suppl. 1996;220:23-6 [8898432] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Manipulating mouse embryonic stem cells. AN - 67001987; 19266324 AB - Murine embryonic stem (ES) cells are derived from the inner cell mass of 3.5-day-old embryo and have the ability to colonize the germline and form normal gametes following in vitro genetic manipulations. This remarkable characteristic of ES cells has provided the basis for studying normal gene function in the mouse by targeted mutagenesis. Nevertheless, ES cells are very sensitive and need to be manipulated with care for them to retain totipotency after extensive in vitro manipulations. Here we provide straightforward protocols for proper care of these cells. Special emphasis is placed on aspects that are particularly critical for proper culture of this cell type. JF - Methods in molecular biology (Clifton, N.J.) AU - Southon, Eileen AU - Tessarollo, Lino AD - Mouse Cancer Genetics Program, NCI-Frederick, Frederick, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 165 EP - 185 VL - 530 SN - 1064-3745, 1064-3745 KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Pregnancy KW - Cell Differentiation -- physiology KW - Embryonic Stem Cells -- physiology KW - Blastocyst -- cytology KW - Embryo, Mammalian -- cytology KW - Cell Culture Techniques -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67001987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Manipulating+mouse+embryonic+stem+cells.&rft.au=Southon%2C+Eileen%3BTessarollo%2C+Lino&rft.aulast=Southon&rft.aufirst=Eileen&rft.date=2009-01-01&rft.volume=530&rft.issue=&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-471-1_9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-05-12 N1 - Date created - 2009-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-471-1_9 ER - TY - JOUR T1 - In vitro antibody affinity maturation targeting germline hotspots. AN - 66986941; 19252855 AB - Affinity-matured antibodies can exhibit increased biological efficacy. Regardless of whether an antibody is isolated from a hybridoma or a human Fv phage library, the antibody affinity for its target may need improvement for therapeutic applications. An increased affinity may allow for a reduced dosage of a therapeutic antibody; toxic side effects may also be reduced. In the immune system, affinity maturation is a process involving somatic hypermutations in B cells. Therefore, germline hotspot residues are most likely to have a major impact on antibody affinity. Here, we describe procedures for germline hotspot mutagenesis with an emphasis on strategies for randomizing hotspots with PCR and phage display, using as an example the anti-CD22 monoclonal antibody. JF - Methods in molecular biology (Clifton, N.J.) AU - Ho, Mitchell AU - Pastan, Ira AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 293 EP - 308, xiv VL - 525 SN - 1064-3745, 1064-3745 KW - Antibodies, Monoclonal KW - 0 KW - Peptide Library KW - Index Medicus KW - Bacteriophages KW - Electroporation KW - Antibodies, Monoclonal -- genetics KW - Models, Molecular KW - Amino Acid Sequence KW - Antibodies, Monoclonal -- chemistry KW - Sequence Analysis, DNA KW - Base Sequence KW - Sequence Alignment KW - Escherichia coli KW - Molecular Sequence Data KW - Enzyme-Linked Immunosorbent Assay KW - Flow Cytometry KW - Germ Cells -- immunology KW - Molecular Biology -- methods KW - Antibody Affinity -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66986941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=In+vitro+antibody+affinity+maturation+targeting+germline+hotspots.&rft.au=Ho%2C+Mitchell%3BPastan%2C+Ira&rft.aulast=Ho&rft.aufirst=Mitchell&rft.date=2009-01-01&rft.volume=525&rft.issue=&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-554-1_15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-22 N1 - Date created - 2009-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Eng. 2000 Dec;13(12):819-24 [11239080] Nucleic Acids Res. 2001 Jan 1;29(1):207-9 [11125093] Proc Natl Acad Sci U S A. 2004 May 11;101(19):7352-6 [15123833] Nature. 1975 Aug 7;256(5517):495-7 [1172191] Nucleic Acids Res. 1991 Aug 11;19(15):4133-7 [1908075] Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):7978-82 [1896445] Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1254-6 [7877964] Curr Opin Immunol. 1995 Apr;7(2):248-54 [7546385] Semin Immunol. 1996 Jun;8(3):159-68 [8738915] Immunol Rev. 1998 Apr;162:107-16 [9602357] Nat Biotechnol. 1999 Jun;17(6):568-72 [10385321] J Biol Chem. 2005 Jan 7;280(1):607-17 [15491997] Adv Drug Deliv Rev. 2006 Aug 7;58(5-6):640-56 [16904789] Adv Drug Deliv Rev. 2006 Dec 30;58(15):1622-54 [17123658] Clin Cancer Res. 2000 Jul;6(7):2835-43 [10914732] Clin Cancer Res. 2002 Apr;8(4):995-1002 [11948105] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-554-1_15 ER - TY - JOUR T1 - Anti-CD22 Onconase: preparation and characterization. AN - 66983221; 19252847 AB - Antibodies can be conjugated to effector molecules to derive targeted therapeutics with properties such as cell-specific cytotoxicity. The murine anti-CD22 antibody RFB4 linked to a member of the ribonuclease A superfamily, Onconase (Onc), becomes a potential drug candidate for non-Hodgkin's lymphoma. Onc is currently in Phase III clinical trials for unresectable malignant mesothelioma but conjugation to RFB4 considerably enhances its specificity for CD22+ lymphomas. RFB4-targeted Onc is effective in preclinical models, causes little non-specific toxicities in mice, and has favorable formulation properties. Derivatization and conjugation of RFB4 and Onc have been optimized. JF - Methods in molecular biology (Clifton, N.J.) AU - Newton, Dianne L AU - Stockwin, Luke H AU - Rybak, Susanna M AD - NCI-Frederick, National Institutes of Health, Frederick, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 425 EP - 43, xiv VL - 525 SN - 1064-3745, 1064-3745 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - Disulfides KW - Recombinant Fusion Proteins KW - Sialic Acid Binding Ig-like Lectin 2 KW - Succinimides KW - N-succinimidyl 3-(2-pyridyldithio)propionate KW - 68181-17-9 KW - RNA, Transfer KW - 9014-25-9 KW - Ribonucleases KW - EC 3.1.- KW - ranpirnase KW - ZE15FIT23E KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Drug Screening Assays, Antitumor KW - Animals KW - RNA, Transfer -- metabolism KW - Humans KW - Recombinant Fusion Proteins -- pharmacology KW - Mice KW - Flow Cytometry KW - Cell Line, Tumor KW - Cell Death -- drug effects KW - Fluorescent Antibody Technique KW - Disulfides -- metabolism KW - Antineoplastic Agents -- pharmacology KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Ribonucleases -- isolation & purification KW - Antibodies, Monoclonal -- isolation & purification KW - Molecular Biology -- methods KW - Ribonucleases -- biosynthesis KW - Ribonucleases -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66983221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Anti-CD22+Onconase%3A+preparation+and+characterization.&rft.au=Newton%2C+Dianne+L%3BStockwin%2C+Luke+H%3BRybak%2C+Susanna+M&rft.aulast=Newton&rft.aufirst=Dianne&rft.date=2009-01-01&rft.volume=525&rft.issue=&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-554-1_22 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-22 N1 - Date created - 2009-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-554-1_22 ER - TY - JOUR T1 - Methodological challenges in intervention studies. AN - 66959924; 19241906 AB - Parental substance abuse is a risk factor for child maltreatment, neglect and multi-generational drug abuse. Developing efficacious, cost-efficient interventions is critical to addressing this growing problem. This article by Brian Porter, Luz Porter, Virginia McCoy, Mayra Lima, Clare Pryce and Sachin Nunnewar highlights lessons learned during the first year of a study based in Florida to evaluate a novel parenting intervention targeting substance-abusing mothers and their babies. JF - Nurse researcher AU - Porter, Brian AU - Porter, Luz AU - McCoy, Virginia AU - Lima, Mayra AU - Pryce, Clare AU - Nunnewar, Sachin AD - National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 43 EP - 63 VL - 16 IS - 2 SN - 1351-5578, 1351-5578 KW - Nursing KW - Infant KW - Parenting KW - Risk Factors KW - Nursing Research KW - Humans KW - Adult KW - Child Abuse KW - Florida KW - Substance-Related Disorders -- therapy KW - Parent-Child Relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66959924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nurse+researcher&rft.atitle=Methodological+challenges+in+intervention+studies.&rft.au=Porter%2C+Brian%3BPorter%2C+Luz%3BMcCoy%2C+Virginia%3BLima%2C+Mayra%3BPryce%2C+Clare%3BNunnewar%2C+Sachin&rft.aulast=Porter&rft.aufirst=Brian&rft.date=2009-01-01&rft.volume=16&rft.issue=2&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Nurse+researcher&rft.issn=13515578&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-14 N1 - Date created - 2009-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypofractionated Conformal Radiotherapy (HCRT) for primary and metastatic lung cancers with small dimension : efficacy and toxicity. AN - 66937780; 19224144 AB - : To report on the clinical outcome of hypofractionated conformal radiotherapy (HCRT) for medically inoperable stage I non-small cell lung carcinoma (NSCLC) or limited pulmonary metastases or = 4 months were considered suitable for analysis. Local response was evaluated with CT imaging 4 months after the end of HCRT and every 3 months thereafter. Local relapse-free survival (LRFS) and overall survival (OS) were calculated with the Kaplan-Meier method. : Local response to the treatment was complete response, partial response, no change, and progressive disease as seen in 29%, 43%, 14%, and 7% of tumors, respectively. LRFS at 1 year and 3 years was 76% and 63%, respectively. Lung toxicities > or = grade 2 were observed in 4/40 patients, but no grade 4. Pericardial effusion occurred in one patient. In stage I NSCLC patients (n = 15) with a median follow-up of 25 months, the 1-year LRFS and OS rates were 88% and 81%, respectively, and the 3-year rates 72% and 61%, respectively. : HCRT is an effective and low-toxic treatment for medically inoperable early-stage lung cancers and pulmonary metastases for all clinicians lacking the aid of a dedicated stereotactic system. JF - Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] AU - Mirri, Maria Alessandra AU - Arcangeli, Giorgio AU - Benassi, Marcello AU - d'Angelo, Annelisa AU - Pinzi, Valentina AU - Caterino, Mauro AU - Rinaldi, Massimo AU - Ceribelli, Anna AU - Strigari, Lidia AD - S.C. Radioterapia Oncologica, Regina Elena National Cancer Institute, Rome, Italy. mamirri@inwind.it Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 27 EP - 33 VL - 185 IS - 1 KW - Index Medicus KW - Dose Fractionation KW - Aged, 80 and over KW - Radiotherapy Dosage KW - Humans KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Radiography KW - Dose-Response Relationship, Radiation KW - Male KW - Female KW - Lung Neoplasms -- radiotherapy KW - Radiotherapy, Conformal -- methods KW - Lung Neoplasms -- secondary KW - Lung Neoplasms -- diagnostic imaging KW - Radiotherapy, Conformal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66937780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Strahlentherapie+und+Onkologie+%3A+Organ+der+Deutschen+Rontgengesellschaft+...+%5Bet+al%5D&rft.atitle=Hypofractionated+Conformal+Radiotherapy+%28HCRT%29+for+primary+and+metastatic+lung+cancers+with+small+dimension+%3A+efficacy+and+toxicity.&rft.au=Mirri%2C+Maria+Alessandra%3BArcangeli%2C+Giorgio%3BBenassi%2C+Marcello%3Bd%27Angelo%2C+Annelisa%3BPinzi%2C+Valentina%3BCaterino%2C+Mauro%3BRinaldi%2C+Massimo%3BCeribelli%2C+Anna%3BStrigari%2C+Lidia&rft.aulast=Mirri&rft.aufirst=Maria&rft.date=2009-01-01&rft.volume=185&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Strahlentherapie+und+Onkologie+%3A+Organ+der+Deutschen+Rontgengesellschaft+...+%5Bet+al%5D&rft.issn=1439-099X&rft_id=info:doi/10.1007%2Fs00066-009-1873-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2009-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00066-009-1873-3 ER - TY - JOUR T1 - Nicotine content and delivery across tobacco products. AN - 66873681; 19184646 AB - Nicotine is the principal alkaloid in both commercial and homemade products (e.g., cigarettes, smokeless tobacco, bidis, waterpipes) followed by nornicotine, anabasine, anatabine, and many other basic substances that contain a cyclic nitrogenous nucleus. Tobacco types, leaf position on the plant, agricultural practices, fertilizer treatment, and degree of ripening are among some prominent factors that determine the levels of alkaloids in tobacco leaf. From a random examination of 152 cultivated varieties of Nicotiana tabacum, a range of alkaloid variation between 0.17 and 4.93% was determined. In fact, every step in tobacco production that affects plant metabolism will influence the level of alkaloid content to a certain degree. Depending on blending recipe, type and amount of additives, and product design, all types of tobacco products contain a very wide range of nicotine concentration. However, the ultimate emission of nicotine to the user, exposure, and psychophar-macological effects depend not only on the content and emission, but also on the relationship between the product and the user. JF - Handbook of experimental pharmacology AU - Djordjevic, Mirjana V AU - Doran, Kelly A AD - Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd, EPN 4048, MSC 7337, Bethesda, MD 20892-7337, USA. djordjev@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 61 EP - 82 IS - 192 SN - 0171-2004, 0171-2004 KW - Alkaloids KW - 0 KW - Nicotinic Agonists KW - Tobacco Smoke Pollution KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Alkaloids -- chemistry KW - Humans KW - Smoking -- metabolism KW - Tobacco Smoke Pollution -- analysis KW - Tobacco, Smokeless -- chemistry KW - Plant Leaves -- chemistry KW - Tobacco -- chemistry KW - Nicotinic Agonists -- chemistry KW - Nicotine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66873681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Nicotine+content+and+delivery+across+tobacco+products.&rft.au=Djordjevic%2C+Mirjana+V%3BDoran%2C+Kelly+A&rft.aulast=Djordjevic&rft.aufirst=Mirjana&rft.date=2009-01-01&rft.volume=&rft.issue=192&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-69248-5_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-07 N1 - Date created - 2009-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-3-540-69248-5_3 ER - TY - JOUR T1 - Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. AN - 66852343; 18978339 AB - Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of single-nucleotide polymorphisms (SNPs) on benzene-induced hematotoxicity, we analyzed 1395 SNPs in 411 genes using an Illumina GoldenGate assay in 250 benzene-exposed workers and 140 unexposed controls. Highly significant findings clustered in five genes (BLM, TP53, RAD51, WDR79 and WRN) that play a critical role in DNA repair and genomic maintenance, and these regions were then further investigated with tagSNPs. One or more SNPs in each gene were associated with highly significant 10-20% reductions (P values ranged from 0.0011 to 0.0002) in the white blood cell (WBC) count among benzene-exposed workers but not controls, with evidence for gene-environment interactions for SNPs in BLM, WRN and RAD51. Further, among workers exposed to benzene, the genotype-associated risk of having a WBC count 8-fold. In vitro functional studies revealed that deletion of SGS1 in yeast, equivalent to lacking BLM and WRN function in humans, caused reduced cellular growth in the presence of the toxic benzene metabolite hydroquinone, and knockdown of WRN using specific short hairpin RNA increased susceptibility of human TK6 cells to hydroquinone toxicity. Our findings suggest that SNPs involved in DNA repair and genomic maintenance, with particular clustering in the homologous DNA recombination pathway, play an important role in benzene-induced hematotoxicity. JF - Carcinogenesis AU - Lan, Qing AU - Zhang, Luoping AU - Shen, Min AU - Jo, William J AU - Vermeulen, Roel AU - Li, Guilan AU - Vulpe, Christopher AU - Lim, Sophia AU - Ren, Xuefeng AU - Rappaport, Stephen M AU - Berndt, Sonja I AU - Yeager, Meredith AU - Yuenger, Jeff AU - Hayes, Richard B AU - Linet, Martha AU - Yin, Songnian AU - Chanock, Stephen AU - Smith, Martyn T AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. qingl@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 50 EP - 58 VL - 30 IS - 1 KW - Benzene KW - J64922108F KW - Index Medicus KW - Occupational Exposure KW - Polymorphism, Single Nucleotide KW - Humans KW - DNA Repair KW - Benzene -- toxicity KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66852343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Large-scale+evaluation+of+candidate+genes+identifies+associations+between+DNA+repair+and+genomic+maintenance+and+development+of+benzene+hematotoxicity.&rft.au=Lan%2C+Qing%3BZhang%2C+Luoping%3BShen%2C+Min%3BJo%2C+William+J%3BVermeulen%2C+Roel%3BLi%2C+Guilan%3BVulpe%2C+Christopher%3BLim%2C+Sophia%3BRen%2C+Xuefeng%3BRappaport%2C+Stephen+M%3BBerndt%2C+Sonja+I%3BYeager%2C+Meredith%3BYuenger%2C+Jeff%3BHayes%2C+Richard+B%3BLinet%2C+Martha%3BYin%2C+Songnian%3BChanock%2C+Stephen%3BSmith%2C+Martyn+T%3BRothman%2C+Nathaniel&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn249 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Biometrics. 1986 Mar;42(1):121-30 [3719049] Science. 2002 Jun 21;296(5576):2225-9 [12029063] J Biol Chem. 2002 Aug 30;277(35):31980-7 [12080066] Am J Ind Med. 2002 Oct;42(4):275-85 [12271475] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Environ Health Perspect. 2003 Aug;111(11):1411-20 [12928149] Cancer Res. 2003 Nov 15;63(22):7657-62 [14633686] Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003 Apr;21(2):86-9 [14761515] Br J Ind Med. 1987 Feb;44(2):124-8 [3814544] Cancer Res. 1990 Jun 1;50(11):3141-5 [2110504] Cancer Res. 1991 Nov 15;51(22):6094-7 [1933872] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Carcinogenesis. 1995 Nov;16(11):2841-6 [7586207] Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6236-40 [8692798] Am J Ind Med. 1996 Mar;29(3):236-46 [8833776] Eur J Haematol Suppl. 1996;60:111-8 [8987252] Environ Health Perspect. 1996 Dec;104 Suppl 6:1247-50 [9118900] Cancer Res. 1997 Jul 15;57(14):2839-42 [9230185] EMBO J. 1998 Jan 15;17(2):598-608 [9430650] Cancer Res. 1998 May 15;58(10):2176-81 [9605763] Carcinogenesis. 1998 Jun;19(6):973-8 [9667733] Mutat Res. 1998 Jul 17;403(1-2):65-73 [9726007] Genes Dev. 1999 Jun 1;13(11):1355-60 [10364153] J Biol Chem. 1999 Oct 8;274(41):29463-9 [10506209] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Cancer Res. 2005 Oct 15;65(20):9152-4 [16230371] Cancer Res. 2005 Oct 15;65(20):9574-81 [16230423] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Carcinogenesis. 2006 Oct;27(10):2083-9 [16728435] Blood. 2006 Dec 1;108(12):3916-8 [16902145] J Med Genet. 2007 Jan;44(1):e61 [17209131] Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):270-5 [17301259] Adv Genet. 2007;58:67-87 [17452246] Genet Epidemiol. 2007 Sep;31(6):553-64 [17487883] Am J Hum Genet. 2007 Dec;81(6):1186-200 [17999359] Mutat Res. 2008 Jan 8;649(1-2):54-61 [17875398] Leuk Res. 2007 Feb;31(2):169-74 [16890287] Ann Occup Hyg. 2004 Mar;48(2):105-16 [14990432] Genes Chromosomes Cancer. 2004 Oct;41(2):109-16 [15287023] Stem Cells. 2004;22(5):750-8 [15342939] Trends Genet. 2000 Jun;16(6):259-64 [10827453] J Toxicol Environ Health A. 2000 Nov;61(5-6):357-72 [11086940] Biochemistry. 2000 Nov 28;39(47):14617-25 [11087418] Nat Genet. 2001 Jan;27(1):113-6 [11138010] Am J Ind Med. 2001 Aug;40(2):117-26 [11494338] Blood. 1978 Aug;52(2):285-92 [667356] Oncogene. 2002 Jun 6;21(25):4065-9 [12037689] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn249 ER - TY - JOUR T1 - Base excision repair of oxidative DNA damage and association with cancer and aging. AN - 66848833; 18978338 AB - Aging has been associated with damage accumulation in the genome and with increased cancer incidence. Reactive oxygen species (ROS) are produced from endogenous sources, most notably the oxidative metabolism in the mitochondria, and from exogenous sources, such as ionizing radiation. ROS attack DNA readily, generating a variety of DNA lesions, such as oxidized bases and strand breaks. If not properly removed, DNA damage can be potentially devastating to normal cell physiology, leading to mutagenesis and/or cell death, especially in the case of cytotoxic lesions that block the progression of DNA/RNA polymerases. Damage-induced mutagenesis has been linked to various malignancies. The major mechanism that cells use to repair oxidative damage lesions, such as 8-hydroxyguanine, formamidopyrimidines, and 5-hydroxyuracil, is base excision repair (BER). The BER pathway in the nucleus is well elucidated. More recently, BER was shown to also exist in the mitochondria. Here, we review the association of BER of oxidative DNA damage with aging, cancer and other diseases. JF - Carcinogenesis AU - Maynard, Scott AU - Schurman, Shepherd H AU - Harboe, Charlotte AU - de Souza-Pinto, Nadja C AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 2 EP - 10 VL - 30 IS - 1 KW - Reactive Oxygen Species KW - 0 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Humans KW - Subcellular Fractions -- metabolism KW - Base Pairing KW - DNA Repair KW - DNA Damage KW - Oxidative Stress KW - Neoplasms -- genetics KW - Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66848833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Base+excision+repair+of+oxidative+DNA+damage+and+association+with+cancer+and+aging.&rft.au=Maynard%2C+Scott%3BSchurman%2C+Shepherd+H%3BHarboe%2C+Charlotte%3Bde+Souza-Pinto%2C+Nadja+C%3BBohr%2C+Vilhelm+A&rft.aulast=Maynard&rft.aufirst=Scott&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn250 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2009-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9 [9012815] Nucleic Acids Res. 1997 Feb 15;25(4):750-5 [9016624] Science. 2005 Jul 15;309(5733):481-4 [16020738] Cancer Epidemiol Biomarkers 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1990;77(5):501-2 [2400824] Cancer Res. 1991 Feb 1;51(3):794-8 [1846317] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn250 ER - TY - JOUR T1 - The role of toxicoproteomics in assessing organ specific toxicity. AN - 66838550; 19157068 AB - Aims of this chapter on the role of toxicoproteomics in assessing organ-specific toxicity are to define the field of toxicoproteomics, describe its development among global technologies, and show potential uses in experimental toxicological research, preclinical testing and mechanistic biological research. Disciplines within proteomics deployed in preclinical research are described as Tier I analysis, involving global protein mapping and protein profiling for differential expression, and Tier II proteomic analysis, including global methods for description of function, structure, interactions and post-translational modification of proteins. Proteomic platforms used in toxicoproteomics research are briefly reviewed. Preclinical toxicoproteomic studies with model liver and kidney toxicants are critically assessed for their contributions toward understanding pathophysiology and in biomarker discovery. Toxicoproteomics research conducted in other organs and tissues are briefly discussed as well. The final section suggests several key developments involving new approaches and research focus areas for the field of toxicoproteomics as a new tool for toxicological pathology. JF - EXS AU - Merrick, B Alex AU - Witzmann, Frank A AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, Durham, NC 27709, USA. merrick@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 367 EP - 400 VL - 99 SN - 1023-294X, 1023-294X KW - Index Medicus KW - Animals KW - Humans KW - Proteomics -- methods KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66838550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EXS&rft.atitle=The+role+of+toxicoproteomics+in+assessing+organ+specific+toxicity.&rft.au=Merrick%2C+B+Alex%3BWitzmann%2C+Frank+A&rft.aulast=Merrick&rft.aufirst=B&rft.date=2009-01-01&rft.volume=99&rft.issue=&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=EXS&rft.issn=1023294X&rft_id=info:doi/ LA 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AN - 66832769; 19153345 AB - Drug hypersensitivity syndrome (DHS) is a severe, multisystem adverse drug reaction that may occur following the use of numerous medications, including anticonvulsants, sulfonamides, and minocycline hydrochloride. Long-term autoimmune sequelae of DHS have been reported, including hypothyroidism. A 15-year-old female adolescent developed DHS 4 weeks after starting minocycline therapy for acne vulgaris. Seven weeks later she developed autoimmune hyperthyroidism (Graves disease), and 7 months after discontinuing minocycline therapy she developed autoimmune type 1 diabetes mellitus. In addition, she developed elevated titers of several markers of systemic autoimmune disease, including antinuclear, anti-Sjögren syndrome A, and anti-Smith antibodies. Minocycline-associated DHS may be associated with multiple autoimmune sequelae, including thyroid disease, type 1 diabetes mellitus, and elevated markers of systemic autoimmunity. Long-term follow-up is needed in patients with DHS to determine the natural history of DHS-associated sequelae. JF - Archives of dermatology AU - Brown, Rebecca J AU - Rother, Kristina I AU - Artman, Henry AU - Mercurio, Mary Gail AU - Wang, Roger AU - Looney, R John AU - Cowen, Edward W AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Rockville, Maryland, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 63 EP - 66 VL - 145 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Minocycline KW - FYY3R43WGO KW - Abridged Index Medicus KW - Index Medicus KW - Graves Disease -- chemically induced KW - Acne Vulgaris -- drug therapy KW - Humans KW - Diabetes Mellitus, Type 1 -- chemically induced KW - Adolescent KW - Female KW - Anti-Bacterial Agents -- therapeutic use KW - Drug Hypersensitivity -- etiology KW - Anti-Bacterial Agents -- adverse effects KW - Autoimmune Diseases -- chemically induced KW - Minocycline -- adverse effects KW - Minocycline -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66832769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+dermatology&rft.atitle=Minocycline-induced+drug+hypersensitivity+syndrome+followed+by+multiple+autoimmune+sequelae.&rft.au=Brown%2C+Rebecca+J%3BRother%2C+Kristina+I%3BArtman%2C+Henry%3BMercurio%2C+Mary+Gail%3BWang%2C+Roger%3BLooney%2C+R+John%3BCowen%2C+Edward+W&rft.aulast=Brown&rft.aufirst=Rebecca&rft.date=2009-01-01&rft.volume=145&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Archives+of+dermatology&rft.issn=1538-3652&rft_id=info:doi/10.1001%2Farchdermatol.2008.521 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2009-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Pediatr. 1999 Oct;11(5):447-56 [10555598] Br J Dermatol. 2007 Sep;157(3):540-6 [17596147] Arch Intern Med. 2002 May 27;162(10):1190-2 [12020192] Diabetes Care. 2002 Dec;25(12):2302-7 [12453977] Arch Dermatol. 2004 Feb;140(2):183-8 [14967790] Arch Dermatol. 2004 Feb;140(2):226-30 [14967800] Diabet Med. 2004 Oct;21(10):1156-7 [15384968] J Invest Dermatol. 1986 Apr;86(4):449-53 [3755739] Clin Pharmacol Ther. 1992 Jan;51(1):56-67 [1732077] Biochem Pharmacol. 1992 Sep 25;44(6):1165-70 [1417938] Antimicrob Agents Chemother. 1996 Apr;40(4):934-40 [8849255] Diabetes. 1997 Jan;46(1):143-9 [8971095] Arthritis Rheum. 2004 Dec 15;51(6):1030-44 [15593352] Toxicology. 2005 Apr 15;209(2):165-7 [15767030] Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9 [15743917] J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S14-7 [16427984] Exp Clin Endocrinol Diabetes. 2006 Jan;114(1):35-8 [16450315] Clin Rheumatol. 2006 Mar;25(2):240-5 [16247581] Pharmacogenet Genomics. 2006 Apr;16(4):297-306 [16538176] Diabetes Care. 2006 May;29(5):1179-80 [16644665] Br J Dermatol. 2006 Aug;155(2):422-8 [16882184] Allergol Int. 2006 Mar;55(1):1-8 [17075280] Br J Dermatol. 2007 May;156(5):1005-9 [17408394] Pediatr Dermatol. 2007 May-Jun;24(3):246-9 [17542873] Curr Opin Allergy Clin Immunol. 2007 Aug;7(4):317-23 [17620823] JAMA. 2001 Mar 7;285(9):1153-4 [11231743] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archdermatol.2008.521 ER - TY - JOUR T1 - Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan. AN - 66830468; 18647964 AB - Screening of the oral cavity and dental care was suggested as mandatory preventive measures of osteonecrosis of the jaw (ONJ) in patients receiving bisphosphonates (BPs). We investigated the occurrence of ONJ before and after implementation of dental preventive measures when starting BP therapy. Since April 2005, 154 consecutive patients treated with BPs (POST-Group) have undergone a baseline mouth assessment (dental visit +/- orthopantomography of the jaws) to detect potential dental conditions and dental care if required. A retrospective review was also conducted of all consecutive cancer patients with bone metastases (PRE-Group) and treated for the first time with BPs from January 1999 to April 2005 in our clinic without receiving any preventive measure. Incidence proportion and incidence rate (IR) were used to estimate the incidence of ONJ. Among the study population (966 patients; male/female=179/787), 73% had breast cancer. 25% of patients were given zoledronic acid (ZOL), 62% pamidronate (PAM), 8% PAM followed by ZOL and 5% clodronate. ONJ was observed in 28 patients (2.9%); we observed a reduction in the incidence of ONJ from 3.2% to 1.3%, when comparing-pre and post-implementation of preventive measures programme. Considering the patients exposed to ZOL, the performance of a dental examination and the application of preventive measures led to a sustained reduction in ONJ IR (7.8% in the PRE-Group versus 1.7% in the POST-Group; P=0.016), with an IR ratio of 0.30 (95% confidence interval 0.03-1.26). ONJ is a manageable and preventable condition. Our data confirm that the application of preventive measures can significantly reduce the incidence of ONJ in cancer patients receiving BPs therapy. Dental exams combined to the identification of patients at risk in cooperation with the Dental Team can improve outcomes and increase the number of ONJ-free patients. JF - Annals of oncology : official journal of the European Society for Medical Oncology AU - Ripamonti, C I AU - Maniezzo, M AU - Campa, T AU - Fagnoni, E AU - Brunelli, C AU - Saibene, G AU - Bareggi, C AU - Ascani, L AU - Cislaghi, E AD - Palliative Care Unit (Pain Therapy and Rehabilitation), IRCCS Foundation, National Cancer Institute of Milan, Milan, Italy. carla.ripamonti@istitutotumori.mi.it Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 137 EP - 145 VL - 20 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Index Medicus KW - Young Adult KW - Humans KW - Retrospective Studies KW - Academies and Institutes KW - Aged KW - Antineoplastic Agents -- adverse effects KW - Aged, 80 and over KW - Adult KW - Imidazoles -- therapeutic use KW - Incidence KW - Middle Aged KW - Italy -- epidemiology KW - Antineoplastic Agents -- therapeutic use KW - Female KW - Male KW - Diphosphonates -- therapeutic use KW - Neoplasms -- drug therapy KW - Osteonecrosis -- prevention & control KW - Bone Neoplasms -- epidemiology KW - Diphosphonates -- adverse effects KW - Osteonecrosis -- epidemiology KW - Jaw Diseases -- prevention & control KW - Neoplasms -- epidemiology KW - Osteonecrosis -- chemically induced KW - Neoplasms -- pathology KW - Bone Neoplasms -- drug therapy KW - Jaw Diseases -- chemically induced KW - Jaw Diseases -- epidemiology KW - Dental Prophylaxis -- utilization KW - Bone Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66830468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.atitle=Decreased+occurrence+of+osteonecrosis+of+the+jaw+after+implementation+of+dental+preventive+measures+in+solid+tumour+patients+with+bone+metastases+treated+with+bisphosphonates.+The+experience+of+the+National+Cancer+Institute+of+Milan.&rft.au=Ripamonti%2C+C+I%3BManiezzo%2C+M%3BCampa%2C+T%3BFagnoni%2C+E%3BBrunelli%2C+C%3BSaibene%2C+G%3BBareggi%2C+C%3BAscani%2C+L%3BCislaghi%2C+E&rft.aulast=Ripamonti&rft.aufirst=C&rft.date=2009-01-01&rft.volume=20&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Annals+of+oncology+%3A+official+journal+of+the+European+Society+for+Medical+Oncology&rft.issn=1569-8041&rft_id=info:doi/10.1093%2Fannonc%2Fmdn526 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-19 N1 - Date created - 2009-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/annonc/mdn526 ER - TY - JOUR T1 - Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers. AN - 66820333; 19009022 AB - Phenotypes related to both nicotine dependence and ability to successfully quit smoking display substantial heritabilities in classical and molecular genetic studies. Twin studies suggest that some genetic components for dependence overlap with genetic components of ability to quit, but that many components do not overlap. Initial genome-wide association (GWA) studies have demonstrated haplotypes that distinguish nicotine-dependent from nondependent smokers. These haplotypes overlap partially with those that distinguish individuals who successfully quit smoking from those who were not able to quit smoking in clinical trials for smoking cessation. We now report novel genome-wide association results from National Institutes of Health research volunteers who reported smoking histories, symptoms of nicotine dependence, and ability to successfully quit smoking outside the context of a clinical trial. These results buttress data from several prior GWA studies. The data from these volunteers support the idea that previously reported studies of genes associated with smoking cessation success in clinical trial participants may also apply to smokers who are more or less able to initiate and sustain abstinence outside of clinical trial settings. JF - Molecular medicine (Cambridge, Mass.) AU - Drgon, Tomas AU - Montoya, Ivan AU - Johnson, Catherine AU - Liu, Qing-Rong AU - Walther, Donna AU - Hamer, Dean AU - Uhl, George R AD - Molecular Neurobiology Branch, National Institutes of Health-Intramural Research Program (National Institute on Drug Abuse), Baltimore, Maryland 21224, United States of America. PY - 2009 SP - 21 EP - 27 VL - 15 IS - 1-2 KW - Index Medicus KW - United States KW - Haplotypes KW - Gene Frequency KW - Humans KW - Treatment Outcome KW - Clinical Trials as Topic KW - Male KW - Female KW - Genome-Wide Association Study KW - Genome, Human KW - Tobacco Use Disorder -- genetics KW - National Institutes of Health (U.S.) KW - Smoking Cessation -- methods KW - Research Subjects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66820333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+medicine+%28Cambridge%2C+Mass.%29&rft.atitle=Genome-wide+association+for+nicotine+dependence+and+smoking+cessation+success+in+NIH+research+volunteers.&rft.au=Drgon%2C+Tomas%3BMontoya%2C+Ivan%3BJohnson%2C+Catherine%3BLiu%2C+Qing-Rong%3BWalther%2C+Donna%3BHamer%2C+Dean%3BUhl%2C+George+R&rft.aulast=Drgon&rft.aufirst=Tomas&rft.date=2009-01-01&rft.volume=15&rft.issue=1-2&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Molecular+medicine+%28Cambridge%2C+Mass.%29&rft.issn=1528-3658&rft_id=info:doi/10.2119%2Fmolmed.2008.00096 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-09 N1 - Date created - 2009-01-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Gen Psychiatry. 2000 Mar;57(3):261-9 [10711912] Ann N Y Acad Sci. 2008 Oct;1141:318-81 [18991966] Am J Hum Genet. 2001 Dec;69(6):1290-300 [11704927] Nicotine Tob Res. 2002 Feb;4(1):115-25 [11906688] Psychol Med. 2004 Jul;34(5):865-79 [15500307] Addict Behav. 1978;3(3-4):235-41 [735910] J Behav Med. 1989 Apr;12(2):159-82 [2668531] Control Clin Trials. 1990 Apr;11(2):116-28 [2161310] Arch Gen Psychiatry. 1992 Sep;49(9):723-7 [1355337] Addict Behav. 1994 Jan-Feb;19(1):33-9 [8197891] J Subst Abuse. 1989;1(4):471-7 [2485293] Biol Psychiatry. 1996 Oct 15;40(8):776-84 [8894071] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Control Clin Trials. 1998 Dec;19(6):589-601 [9875838] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] Twin Res Hum Genet. 2006 Feb;9(1):64-72 [16611469] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):918-25 [17099884] Hum Mol Genet. 2007 Jan 1;16(1):36-49 [17135278] Hum Mol Genet. 2007 Jan 1;16(1):24-35 [17158188] BMC Genet. 2007;8:10 [17407593] Arch Gen Psychiatry. 2008 Mar;65(3):345-55 [18316681] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Nat Genet. 2008 May;40(5):616-22 [18385676] Arch Gen Psychiatry. 2008 Jun;65(6):683-93 [18519826] Am J Med Genet. 2000 Oct 9;96(5):665-70 [11054775] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2119/molmed.2008.00096 ER - TY - JOUR T1 - Curing of yeast [URE3] prion by the Hsp40 cochaperone Ydj1p is mediated by Hsp70. AN - 66814114; 19015537 AB - [URE3] is a prion of the yeast Ure2 protein. Hsp40 is a cochaperone that regulates Hsp70 chaperone activity. When overexpressed, the Hsp40 Ydj1p cures yeast of [URE3], but the Hsp40 Sis1p does not. On the basis of biochemical data Ydj1p has been proposed to cure [URE3] by binding soluble Ure2p and preventing it from joining prion aggregates. Here, we mutagenized Ydj1p and find that disrupting substrate binding, dimerization, membrane association, or ability to transfer substrate to Hsp70 had little or no effect on curing. J-domain point mutations that disrupt functional interactions of Ydj1p with Hsp70 abolished curing, and the J domain alone cured [URE3]. Consistent with heterologous J domains possessing similar Hsp70 regulatory activity, the Sis1p J domain also cured [URE3]. We further show that Ydj1p is not essential for [URE3] propagation and that depletion of Ure2p is lethal in cells lacking Ydj1p. Our data imply that curing of [URE3] by overproduced Ydj1p does not involve direct interaction of Ydj1p with Ure2p but rather works through regulation of Hsp70 through a specific J-protein/Hsp70 interaction. JF - Genetics AU - Sharma, Deepak AU - Stanley, Robert F AU - Masison, Daniel C AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0851, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 129 EP - 137 VL - 181 IS - 1 SN - 0016-6731, 0016-6731 KW - HSP40 Heat-Shock Proteins KW - 0 KW - HSP70 Heat-Shock Proteins KW - Heat-Shock Proteins KW - Mutant Proteins KW - Prions KW - SIS1 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - YDJ1 protein, S cerevisiae KW - 139874-78-5 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - URE2 protein, S cerevisiae KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Microbial Viability KW - Mutant Proteins -- metabolism KW - Mutation -- genetics KW - Spores, Fungal -- cytology KW - Protein Structure, Tertiary KW - Prenylation KW - Protein Multimerization KW - Heat-Shock Proteins -- chemistry KW - Saccharomyces cerevisiae Proteins -- metabolism KW - HSP70 Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - HSP40 Heat-Shock Proteins -- chemistry KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Prions -- metabolism KW - HSP40 Heat-Shock Proteins -- metabolism KW - Saccharomyces cerevisiae -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66814114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Curing+of+yeast+%5BURE3%5D+prion+by+the+Hsp40+cochaperone+Ydj1p+is+mediated+by+Hsp70.&rft.au=Sharma%2C+Deepak%3BStanley%2C+Robert+F%3BMasison%2C+Daniel+C&rft.aulast=Sharma&rft.aufirst=Deepak&rft.date=2009-01-01&rft.volume=181&rft.issue=1&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/10.1534%2Fgenetics.108.098699 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-06 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Plant Cell. 2000 Apr;12(4):457-60 [10760235] Mol Biol Cell. 2003 Mar;14(3):1172-81 [12631732] Curr Biol. 2000 Nov 16;10(22):1443-6 [11102806] EMBO J. 2001 May 15;20(10):2435-42 [11350932] Curr Microbiol. 2001 Jul;43(1):7-10 [11375656] Mol Cell Biol. 2001 Oct;21(20):7035-46 [11564886] Mol Cell Biol. 2002 Jun;22(11):3590-8 [11997496] Genetics. 2002 Nov;162(3):1045-53 [12454054] Genetics. 2003 Feb;163(2):495-506 [12618389] J Biol Chem. 2003 Nov 7;278(45):44457-66 [12941935] Structure. 2003 Dec;11(12):1475-83 [14656432] Mol Cell Biol. 2004 May;24(9):3928-37 [15082786] J Biol Chem. 2004 Oct 22;279(43):44376-83 [15302880] Genetics. 1989 May;122(1):19-27 [2659436] Methods Enzymol. 1991;194:281-301 [2005793] Methods Enzymol. 1991;194:3-21 [2005794] J Cell Biol. 1991 Aug;114(4):609-21 [1869583] J Biol Chem. 1992 Sep 15;267(26):18890-5 [1527016] Cell. 1992 Dec 24;71(7):1143-55 [1473150] Science. 1995 Oct 6;270(5233):93-5 [7569955] J Biol Chem. 1996 Apr 19;271(16):9347-54 [8621599] Mol Cell Biol. 1996 Sep;16(9):4773-81 [8756635] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12503-8 [9356479] Cell. 1998 Jul 10;94(1):73-82 [9674429] J Biol Chem. 1998 Oct 23;273(43):27824-30 [9774392] Protein Sci. 1999 Jan;8(1):203-14 [10210198] J Biol Chem. 1999 Oct 22;274(43):30534-9 [10521435] J Biol Chem. 2005 Jan 7;280(1):695-702 [15496404] Biochem J. 2005 Mar 15;386(Pt 3):453-60 [15500443] EMBO J. 2005 Sep 7;24(17):3082-92 [16096644] Cell. 2006 May 5;125(3):443-51 [16678092] Genetics. 2006 Jun;173(2):611-20 [16582428] J Biol Chem. 2007 Apr 20;282(16):11931-40 [17324933] Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7163-8 [17438278] Mol Biol Cell. 2007 Jun;18(6):2149-54 [17392510] Nat Rev Microbiol. 2007 Aug;5(8):611-8 [17632572] EMBO J. 2007 Aug 22;26(16):3794-803 [17673909] Proc Natl Acad Sci U S A. 2008 May 20;105(20):7206-11 [18480252] J Biol Chem. 2008 Jun 6;283(23):15732-9 [18400756] Mol Cell Biol. 2008 Jul;28(13):4434-44 [18443039] Genetics. 2008 Jul;179(3):1301-11 [18562668] J Mol Biol. 2008 Oct 31;383(1):155-66 [18723025] Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16596-601 [18955697] Mol Cell Biol. 2000 Dec;20(23):8916-22 [11073991] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1534/genetics.108.098699 ER - TY - JOUR T1 - Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan. AN - 66813721; 19138047 AB - Risk factors for thyroid cancer remain largely unknown except for ionizing radiation exposure during childhood and a history of benign thyroid nodules. Because thyroid nodules are more common than thyroid cancers and are associated with thyroid cancer risk, we evaluated several polymorphisms potentially relevant to thyroid tumors and assessed interaction with ionizing radiation exposure to the thyroid gland. Thyroid nodules were detected in 1998 by ultrasound screening of 2997 persons who lived near the Semipalatinsk nuclear test site in Kazakhstan when they were children (1949-1962). Cases with thyroid nodules (n = 907) were frequency matched (1:1) to those without nodules by ethnicity (Kazakh or Russian), gender and age at screening. Thyroid gland radiation doses were estimated from fallout deposition patterns, residence history and diet. We analyzed 23 polymorphisms in 13 genes and assessed interaction with ionizing radiation exposure using likelihood ratio tests (LRT). Elevated thyroid nodule risks were associated with the minor alleles of RET S836S (rs1800862, P = 0.03) and GFRA1 -193C>G (rs not assigned, P = 0.05) and decreased risk with XRCC1 R194W (rs1799782, P trend = 0.03) and TGFB1 T263I (rs1800472, P = 0.009). Similar patterns of association were observed for a small number of papillary thyroid cancers (n = 25). Ionizing radiation exposure to the thyroid gland was associated with significantly increased risk of thyroid nodules (age and gender adjusted excess odds ratio/Gy = 0.30, 95% CI 0.05-0.56), with evidence for interaction by genotype found for XRCC1 R194W (LRT P value = 0.02). Polymorphisms in RET signaling, DNA repair and proliferation genes may be related to risk of thyroid nodules, consistent with some previous reports on thyroid cancer. Borderline support for gene-radiation interaction was found for a variant in XRCC1, a key base excision repair protein. Other pathways such as genes in double-strand break repair, apoptosis and genes related to proliferation should also be pursued. JF - Radiation research AU - Sigurdson, Alice J AU - Land, Charles E AU - Bhatti, Parveen AU - Pineda, Marbin AU - Brenner, Alina AU - Carr, Zhanat AU - Gusev, Boris I AU - Zhumadilov, Zhaxibay AU - Simon, Steven L AU - Bouville, Andre AU - Rutter, Joni L AU - Ron, Elaine AU - Struewing, Jeffery P AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. sigurdsa@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 77 EP - 88 VL - 171 IS - 1 SN - 0033-7587, 0033-7587 KW - Thyrotropin KW - 9002-71-5 KW - DNA KW - 9007-49-2 KW - Proto-Oncogene Proteins c-ret KW - EC 2.7.10.1 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Thyrotropin -- genetics KW - Humans KW - DNA -- genetics KW - Adult KW - Aged KW - Middle Aged KW - Kazakhstan KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Proto-Oncogene Proteins c-ret -- genetics KW - DNA Repair -- radiation effects KW - Polymorphism, Genetic -- genetics KW - Neoplasms, Radiation-Induced -- genetics KW - Thyroid Nodule -- genetics KW - Environmental Exposure -- adverse effects KW - Nuclear Weapons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66813721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Thyroid+nodules%2C+polymorphic+variants+in+DNA+repair+and+RET-related+genes%2C+and+interaction+with+ionizing+radiation+exposure+from+nuclear+tests+in+Kazakhstan.&rft.au=Sigurdson%2C+Alice+J%3BLand%2C+Charles+E%3BBhatti%2C+Parveen%3BPineda%2C+Marbin%3BBrenner%2C+Alina%3BCarr%2C+Zhanat%3BGusev%2C+Boris+I%3BZhumadilov%2C+Zhaxibay%3BSimon%2C+Steven+L%3BBouville%2C+Andre%3BRutter%2C+Joni+L%3BRon%2C+Elaine%3BStruewing%2C+Jeffery+P&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2009-01-01&rft.volume=171&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1327.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-25 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Causes Control. 1999 Dec;10(6):583-95 [10616827] Radiat Res. 2008 Apr;169(4):373-83 [18363427] Epidemiology. 2000 Nov;11(6):684-8 [11055630] Cancer Epidemiol Biomarkers Prev. 2001 Feb;10(2):113-7 [11219767] Oncogene. 2001 Apr 19;20(17):2161-70 [11360200] Clin Endocrinol (Oxf). 2001 Aug;55(2):143-58 [11531919] Radiat Res. 2001 Nov;156(5 Pt 2):618-27 [11604083] J Clin Endocrinol Metab. 2001 Nov;86(11):5307-12 [11701697] J Med Genet. 2002 Apr;39(4):260-5 [11950855] Radiat Environ Biophys. 2002 Mar;41(1):75-80 [12014415] Nucleic Acids Res. 2002 Dec 1;30(23):5213-21 [12466546] Thyroid. 2002 Nov;12(11):1017-22 [12490080] Cancer Epidemiol Biomarkers Prev. 2003 Jan;12(1):14-22 [12540498] J Cell Physiol. 2003 May;195(2):168-86 [12652644] Endocr J. 2003 Feb;50(1):85-9 [12733713] Eur J Cancer. 2004 Mar;40(5):754-60 [15010077] IARC Sci Publ. 2004;(157):105-25 [15055293] Cancer Epidemiol Biomarkers Prev. 2004 Jun;13(6):1013-21 [15184258] Radiat Res. 1992 Jul;131(1):98-111 [1385649] Radiat Res. 1995 Mar;141(3):259-77 [7871153] Mutat Res. 1995 Dec;333(1-2):123-9 [8538619] Radiat Environ Biophys. 1997 Sep;36(3):201-4 [9402637] Clin Endocrinol (Oxf). 2005 Mar;62(3):380-6 [15730424] Thyroid. 2005 Feb;15(2):94-9 [15753665] Laryngoscope. 2005 Jun;115(6):938-45 [15933498] Laryngoscope. 2005 Jun;115(6):1035-41 [15933516] Ann Intern Med. 2005 Jun 7;142(11):926-31 [15941700] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2407-12 [16214924] J Clin Endocrinol Metab. 2005 Nov;90(11):6268-74 [16091499] Nat Rev Cancer. 2006 Apr;6(4):292-306 [16557281] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):174-7 [17220349] Pharmacogenomics. 2007 Jun;8(6):527-32 [17559340] Int J Epidemiol. 2000 Feb;29(1):158-67 [10750618] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1667/RR1327.1 ER - TY - JOUR T1 - Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. AN - 66811257; 19139015 AB - The increased molecular understanding of cancerous growth may now afford the opportunity to develop novel therapies targeting specific dysregulated molecular mechanisms contributing to the progression of each cancer type. In this regard, the aberrant activation of Akt/mammalian target of rapamycin (mTOR) pathway is a frequent event in head and neck squamous cell carcinomas (HNSCC), thus representing a potential molecular target for the treatment of HNSCC patients. The ability to translate this emerging body of information into effective therapeutic strategies, however, has been hampered by the limited availability of animal models for oral malignancies. Here, we show that the administration in the drinking water to mice of 4-nitroquinoline-1 oxide, a DNA adduct-forming agent that serves as a surrogate of tobacco exposure, leads to the progressive appearance of preneoplastic and tumoral lesions in the tongue and oral mucosa, with 100% incidence after only 16 weeks of carcinogen exposure. Remarkably, many of these lesions evolve spontaneously into highly malignant SCCs few weeks after 4-nitroquinoline-1 oxide withdrawal. In this model, we have observed that the activation of the Akt-mTOR biochemical route represents an early event, which is already detectable in dysplastic lesions. Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs. Together, these findings support the contribution of the mTOR signaling pathway to HNSCC progression and provide a strong rationale for the early evaluation of mTOR inhibitors as a molecular-targeted strategy for HNSCC chemoprevention and treatment. JF - Cancer prevention research (Philadelphia, Pa.) AU - Czerninski, Rakefet AU - Amornphimoltham, Panomwat AU - Patel, Vyomesh AU - Molinolo, Alfredo A AU - Gutkind, J Silvio AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, 30 Convent Drive, Building 30, Bethesda, MD 20892-4340, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 27 EP - 36 VL - 2 IS - 1 KW - Antibiotics, Antineoplastic KW - 0 KW - Carcinogens KW - 4-Nitroquinoline-1-oxide KW - 56-57-5 KW - Protein Kinases KW - EC 2.7.- KW - TOR Serine-Threonine Kinases KW - EC 2.7.1.1 KW - mTOR protein, mouse KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinogens -- toxicity KW - Disease Progression KW - Cell Transformation, Neoplastic -- drug effects KW - Mice KW - 4-Nitroquinoline-1-oxide -- toxicity KW - Signal Transduction -- drug effects KW - Mice, Inbred C57BL KW - Immunohistochemistry KW - Female KW - Protein Kinases -- biosynthesis KW - Carcinoma, Squamous Cell -- metabolism KW - Head and Neck Neoplasms -- pathology KW - Precancerous Conditions -- drug therapy KW - Precancerous Conditions -- metabolism KW - Head and Neck Neoplasms -- drug therapy KW - Precancerous Conditions -- pathology KW - Head and Neck Neoplasms -- metabolism KW - Antibiotics, Antineoplastic -- pharmacology KW - Carcinoma, Squamous Cell -- pathology KW - Protein Kinases -- drug effects KW - Sirolimus -- pharmacology KW - Carcinoma, Squamous Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66811257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Targeting+mammalian+target+of+rapamycin+by+rapamycin+prevents+tumor+progression+in+an+oral-specific+chemical+carcinogenesis+model.&rft.au=Czerninski%2C+Rakefet%3BAmornphimoltham%2C+Panomwat%3BPatel%2C+Vyomesh%3BMolinolo%2C+Alfredo+A%3BGutkind%2C+J+Silvio&rft.aulast=Czerninski&rft.aufirst=Rakefet&rft.date=2009-01-01&rft.volume=2&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-08-0147 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-18 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Cancer Prev Res (Phila). 2009 Jan;2(1):10-3 [19139012] Cancer Prev Res (Phila). 2009 Jan;2(1):7-9 [19139011] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-08-0147 ER - TY - JOUR T1 - Inflammation-associated serum and colon markers as indicators of dietary attenuation of colon carcinogenesis in ob/ob mice. AN - 66811177; 19139019 AB - Although inflammatory cytokines and obesity-associated serum proteins have been reported as biomarkers of colorectal adenoma risk in humans, little is known of biomarkers of response to interventions that attenuate tumorigenesis. Dietary navy beans and their fractions attenuate colon carcinogenesis in carcinogen-induced genetically obese mice. We hypothesized that this attenuation would be associated with changes in inflammatory cytokines and obesity-related serum proteins that may serve as measures of efficacy. ob/ob mice (n = 160) were injected with the carcinogen azoxymethane (AOM) to induce colon cancer and randomly placed on one of four diets (control, whole navy bean, bean residue fraction, or bean extract fraction) for 26 to 28 wk. Serum was analyzed for 14 inflammation- or obesity-related proteins, and colon RNA was analyzed for expression of 84 inflammation-associated genes. Six of 14 serum proteins were increased [i.e., interleukin (IL)-4, IL-5, IL-6, IL-10, IFN gamma, granulocyte macrophage colony-stimulating factor] in hyperplastic/dysplastic stages of colon carcinogenesis. Bean-fed mice had significantly higher monocyte chemoattractant protein-1 and lower IL-6 levels in serum. In colon mucosa, 55 of 84 inflammation-associated genes differed between AOM-induced and noninduced mice. Of the 55 AOM-induced genes, 5 were counteracted by bean diets, including IL-6 whose increase in expression levels was attenuated by bean diets in AOM-induced mice. In summary, IL-6 emerged as a serum protein that was increased in hyperplastic/dysplastic stages of colon carcinogenesis, but attenuated with bean-based diet in serum and colon mucosa. Changes in a subset of inflammation-associated serum proteins and colon gene expression may serve as response indicators of dietary attenuation of colon carcinogenesis. JF - Cancer prevention research (Philadelphia, Pa.) AU - Mentor-Marcel, Roycelynn A AU - Bobe, Gerd AU - Barrett, Kathleen G AU - Young, Matthew R AU - Albert, Paul S AU - Bennink, Maurice R AU - Lanza, Elaine AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA. marcelr@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 60 EP - 69 VL - 2 IS - 1 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Cytokines KW - Interleukin-6 KW - Plant Extracts KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Precancerous Conditions -- diet therapy KW - Azoxymethane -- toxicity KW - Mice, Obese KW - Carcinogens -- toxicity KW - Mice KW - Precancerous Conditions -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Obesity -- complications KW - Precancerous Conditions -- genetics KW - Interleukin-6 -- genetics KW - Biomarkers, Tumor -- analysis KW - Diet KW - Interleukin-6 -- biosynthesis KW - Male KW - Fabaceae -- chemistry KW - Phytotherapy KW - Cytokines -- genetics KW - Colonic Neoplasms -- genetics KW - Cytokines -- biosynthesis KW - Colonic Neoplasms -- diet therapy KW - Inflammation -- genetics KW - Inflammation -- metabolism KW - Cytokines -- metabolism KW - Colonic Neoplasms -- metabolism KW - Plant Extracts -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66811177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.atitle=Inflammation-associated+serum+and+colon+markers+as+indicators+of+dietary+attenuation+of+colon+carcinogenesis+in+ob%2Fob+mice.&rft.au=Mentor-Marcel%2C+Roycelynn+A%3BBobe%2C+Gerd%3BBarrett%2C+Kathleen+G%3BYoung%2C+Matthew+R%3BAlbert%2C+Paul+S%3BBennink%2C+Maurice+R%3BLanza%2C+Elaine%3BColburn%2C+Nancy+H&rft.aulast=Mentor-Marcel&rft.aufirst=Roycelynn&rft.date=2009-01-01&rft.volume=2&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Cancer+prevention+research+%28Philadelphia%2C+Pa.%29&rft.issn=1940-6215&rft_id=info:doi/10.1158%2F1940-6207.CAPR-08-0086 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-18 N1 - Date created - 2009-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2007 Jun;92(6):2240-7 [17374712] Endocrinology. 2007 Jan;148(1):241-51 [17038556] Obesity (Silver Spring). 2007 Aug;15(8):1988-95 [17712116] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2128-35 [17932361] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2150-4 [17932364] Environ Health Perspect. 2007 Oct;115(10):1467-73 [17938737] J Nutr. 2007 Nov;137(11):2391-8 [17951475] Am J Physiol Endocrinol Metab. 2007 Nov;293(5):E1153-8 [17726148] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2373-8 [18006926] J Clin Invest. 2007 Dec;117(12):3660-3 [18060028] Cancer Res. 2008 Jan 1;68(1):323-8 [18172326] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Trends Mol Med. 2008 Mar;14(3):109-19 [18261959] Nutr Cancer. 2008;60(3):373-81 [18444172] Curr Opin Genet Dev. 2008 Feb;18(1):3-10 [18325755] Proc Natl Acad Sci U S A. 2008 May 27;105(21):7534-9 [18490655] Cancer. 2000 May 15;88(10):2398-424 [10820364] Lancet. 2001 Feb 17;357(9255):539-45 [11229684] Oncogene. 2002 Jun 6;21(25):3949-60 [12037677] Gastroenterology. 2002 Jun;122(7):2011-25 [12055606] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Nutr Cancer. 2002;44(1):60-5 [12672642] J Nutr. 2004 Oct;134(10):2673-7 [15465765] Physiol Rev. 1979 Jul;59(3):719-809 [379887] Endocrinology. 1980 Sep;107(3):671-6 [6249569] Science. 1993 Jan 1;259(5091):87-91 [7678183] J Nutr. 1993 Nov;123(11):1939-51 [8229312] Nutr Cancer. 1997;27(2):206-9 [9121951] J Clin Invest. 1997 Sep 1;100(5):1174-9 [9276734] J Nutr. 1997 Dec;127(12):2328-33 [9405582] J Clin Invest. 1998 Feb 15;101(4):746-54 [9466968] J Clin Endocrinol Metab. 1998 Mar;83(3):847-50 [9506738] Anticancer Res. 2004 Sep-Oct;24(5A):3049-55 [15517915] J Biol Chem. 2005 Mar 4;280(9):8260-5 [15613481] Cancer Res. 2005 Jun 1;65(11):4673-82 [15930285] Int J Cancer. 2005 Oct 10;116(6):949-56 [15856455] Obes Res. 2005 Aug;13(8):1311-20 [16129712] J Clin Endocrinol Metab. 2005 Oct;90(10):5834-40 [16091493] J Lipid Res. 2005 Nov;46(11):2347-55 [16150820] Eur J Cancer. 2005 Nov;41(16):2502-12 [16199153] Nat Clin Pract Oncol. 2005 Feb;2(2):90-7; quiz 1 p following 113 [16264881] Am J Clin Nutr. 2006 Feb;83(2):461S-465S [16470013] J Nutr Biochem. 2006 Mar;17(3):145-56 [16426829] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):389-94 [16492934] Proteomics. 2006 May;6(9):2844-52 [16596712] Br J Cancer. 2006 Jun 19;94(12):1898-905 [16755300] J Nutr. 2006 Jul;136(7):1896-903 [16772456] Obesity (Silver Spring). 2006 May;14(5):799-811 [16855189] Int J Obes (Lond). 2006 Sep;30(9):1347-55 [16534530] Mutat Res. 2007 Sep 1;622(1-2):103-16 [17574631] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1940-6207.CAPR-08-0086 ER - TY - JOUR T1 - A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2. AN - 66807546; 19036901 AB - The progesterone receptor (PR) plays a pivotal role in proper development and function of the mammary gland and has also been implicated in mammary tumorigenesis. PR is a ligand-activated transcription factor; however, relatively, little is known about its mechanisms of action at endogenous target promoters. The aim of our study was to identify a natural PR-responsive gene and investigate its transcriptional regulation in the mammary microenvironment. Our experiments revealed FKBP5 as a direct target of the PR, because it exhibited a rapid activation by progestin that was cycloheximide independent and correlated with recruitment of RNA polymerase II to the promoter. Site-directed mutagenesis and chromatin immunoprecipitation assays showed that progestin responsiveness is mediated through a composite element in the first intron, to which the PR binds concomitantly with GATA-2. Mutational analysis of the element revealed that the GATA-2 site is essential for progestin activation. Direct binding of PR to DNA contributes to the efficiency of activation but is not sufficient, suggesting that the receptor makes important protein-protein interactions as part of its mechanism of action at the FKBP5 promoter. Using chromatin immunoprecipitation assays we also determined that the intronic region is in communication with the promoter, probably via DNA looping. Time course analysis revealed a cyclical pattern of PR recruitment to the FKBP5 gene but a persistent recruitment to the mouse mammary tumor virus promoter, indicating that receptor cycling is a gene-specific phenomenon rather than a characteristic of the receptor itself. Our study offers new insight in the nature of PR-regulated transcription in mammary cancer cells. JF - Molecular endocrinology (Baltimore, Md.) AU - Magklara, Angeliki AU - Smith, Catharine L AD - Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 61 EP - 73 VL - 23 IS - 1 SN - 0888-8809, 0888-8809 KW - DNA, Neoplasm KW - 0 KW - GATA2 Transcription Factor KW - Gata2 protein, mouse KW - Receptors, Progesterone KW - Recombinant Proteins KW - Promegestone KW - 9XE0V2SQYX KW - Tacrolimus Binding Proteins KW - EC 5.2.1.- KW - tacrolimus binding protein 5 KW - EC 5.2.1.8 KW - Index Medicus KW - Animals KW - HeLa Cells KW - Humans KW - Mammary Neoplasms, Experimental -- genetics KW - Mice KW - Cell Line, Tumor KW - Recombinant Proteins -- genetics KW - Mammary Neoplasms, Experimental -- metabolism KW - Models, Biological KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Mammary Tumor Virus, Mouse -- genetics KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Promegestone -- pharmacology KW - Chromatin Immunoprecipitation KW - Genes, Reporter KW - DNA, Neoplasm -- genetics KW - Binding Sites -- genetics KW - DNA, Neoplasm -- metabolism KW - Female KW - Tacrolimus Binding Proteins -- genetics KW - Receptors, Progesterone -- metabolism KW - Introns KW - GATA2 Transcription Factor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66807546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=A+composite+intronic+element+directs+dynamic+binding+of+the+progesterone+receptor+and+GATA-2.&rft.au=Magklara%2C+Angeliki%3BSmith%2C+Catharine+L&rft.aulast=Magklara&rft.aufirst=Angeliki&rft.date=2009-01-01&rft.volume=23&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/10.1210%2Fme.2008-0028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/me.2008-0028 ER - TY - JOUR T1 - Genetic signature for human risk assessment: lessons from trichloroethylene. AN - 66807296; 19031419 AB - Trichloroethylene (TCE), an organic solvent commonly used for metal degreasing and as a chemical additive, is a significant environmental contaminant that poses health concerns in humans. The US Environmental Protection Agency (EPA) is currently revising the 2001 TCE human risk assessment draft. The next draft is expected to be ready in 2008. TCE metabolites are detectable in humans and carry varying potencies for induction of cancers in animals. Genomic mechanisms have been explored in animals and humans to link TCE to carcinogenesis. DNA analysis provides an opportunity for detection of unique genetic alterations representing a signature of TCE exposure. These alterations can arise from genotoxic and nongenotoxic pathways at multiple points throughout tumorigenesis. Although fixation of alterations may require several stages of selection and modification, the spectra can be specific to TCE. Only a fraction of these alterations eventually lead to tumor formation and some contribute to tumor progression. Genetic events in two major TCE target organs are reviewed, including the VHL gene in kidney, and the Ras gene and genome-wide hypomethylation in liver. Attempts to identify a genetic signature of TCE exposure are challenged by inconsistent findings, lack of evidence of promutagenic lesions, biological relevance of specific genomic changes, and likelihood of coexposures. For human risk assessment, genome-wide screening is useful and is possible with the development of new DNA-sequencing technologies. Genetic screening for preneoplastic and tumor tissues from high-risk population is proposed to exclude the noise of passenger mutations and genetic polymorphisms. JF - Environmental and molecular mutagenesis AU - Shiao, Yih-Horng AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. shiao@mail.ncifcrf.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 68 EP - 77 VL - 50 IS - 1 KW - Trichloroethylene KW - 290YE8AR51 KW - Von Hippel-Lindau Tumor Suppressor Protein KW - EC 2.3.2.27 KW - VHL protein, human KW - EC 6.3.2.- KW - Index Medicus KW - United States KW - Kidney Neoplasms -- genetics KW - United States Environmental Protection Agency KW - Kidney Neoplasms -- chemically induced KW - Humans KW - Von Hippel-Lindau Tumor Suppressor Protein -- genetics KW - Environmental Exposure KW - Mutation KW - Risk Assessment KW - Trichloroethylene -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66807296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Genetic+signature+for+human+risk+assessment%3A+lessons+from+trichloroethylene.&rft.au=Shiao%2C+Yih-Horng&rft.aulast=Shiao&rft.aufirst=Yih-Horng&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20432 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Genet. 2008 Mar;24(3):133-41 [18262675] Environ Health Perspect. 2000 May;108 Suppl 2:177-200 [10807551] Environ Health Perspect. 2000 May;108 Suppl 2:215-23 [10807553] Environ Health Perspect. 2000 Jul;108(7):579-88 [10905993] Ann N Y Acad Sci. 2000;919:79-85 [11083100] Science. 2001 Feb 16;291(5507):1304-51 [11181995] Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1583-8 [11171994] Nature. 2001 Feb 15;409(6822):860-921 [11237011] Curr Opin Neurol. 2001 Dec;14(6):695-703 [11723376] Toxicol Appl Pharmacol. 2002 Jul 1;182(1):55-65 [12127263] Nat Genet. 2002 Dec;32(4):614-21 [12415268] Nature. 2002 Dec 5;420(6915):520-62 [12466850] Science. 2003 Apr 18;300(5618):489-92 [12702876] Lancet. 2003 Jun 14;361(9374):2059-67 [12814730] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8424-9 [12826609] Cancer Res. 2003 Sep 1;63(17):5320-8 [14500363] Curr Med Chem. 2003 Nov;10(22):2461-70 [14529485] Hum Mutat. 2004 Jan;23(1):40-6 [14695531] Toxicology. 2004 Mar 1;196(1-2):127-36 [15036762] IARC Sci Publ. 2004;(157):247-70 [15055300] Nature. 2004 Apr 1;428(6982):493-521 [15057822] Toxicol Lett. 2004 Jun 15;151(1):301-10 [15177666] Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:40-8 [15209402] Nature. 1975 Mar 20;254(5497):261-2 [1113893] Annu Rev Genet. 1986;20:201-30 [3545059] Science. 1990 Sep 14;249(4974):1288-90 [1697983] Science. 1991 Nov 15;254(5034):1001-3 [1948068] J Biol Chem. 1992 Jan 5;267(1):166-72 [1730583] Carcinogenesis. 1994 Oct;15(10):2255-61 [7955063] Mutagenesis. 1994 Sep;9(5):429-37 [7837977] Environ Health Perspect. 1994 Sep;102 Suppl 3:57-61 [7843138] Carcinogenesis. 1995 Mar;16(3):495-500 [7697804] Cancer Lett. 1995 Jun 29;93(1):17-48 [7600541] Nat Med. 1995 Aug;1(8):822-6 [7585187] Regul Toxicol Pharmacol. 1996 Feb;23(1 Pt 1):2-13 [8628915] Science. 1996 Oct 18;274(5286):430-2 [8832894] Cancer Lett. 1996 Nov 29;108(2):257-61 [8973603] IARC Monogr Eval Carcinog Risks Hum. 1995;63:33-477 [9139128] Arch Toxicol. 1997;71(5):332-5 [9137812] Mutat Res. 1997 Apr 24;390(1-2):51-7 [9150752] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9102-7 [9256442] Chem Biol Interact. 1997 Sep 12;106(2):109-21 [9366897] Chem Res Toxicol. 1998 Sep;11(9):1082-8 [9760283] J Natl Cancer Inst. 1998 Nov 18;90(22):1720-3 [9827526] J Natl Cancer Inst. 1999 May 19;91(10):854-61 [10340905] Proc R Soc Med. 1965 May;58:295-300 [14283879] Cell. 2004 Dec 17;119(6):847-60 [15607980] Cell. 2004 Dec 17;119(6):861-72 [15607981] Pharmacogenomics. 2005 Jun;6(4):373-82 [16004555] Hum Mutat. 2005 Sep;26(3):184-91 [16086365] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] Bull World Health Organ. 2005 Oct;83(10):792-5 [16283057] Cancer Res. 2006 Mar 1;66(5):2576-83 [16510575] Genetics. 2006 Aug;173(4):2187-98 [16783027] Environ Health Perspect. 2006 Sep;114(9):1457-63 [16966105] Environ Health Perspect. 2006 Sep;114(9):1471-8 [16966107] Science. 2006 Oct 13;314(5797):268-74 [16959974] Hum Mutat. 2007 Feb;28(2):143-9 [17024664] Nature. 2007 Mar 8;446(7132):153-8 [17344846] World J Gastroenterol. 2007 Apr 28;13(16):2271-82 [17511024] Cancer Genomics Proteomics. 2007 May-Jun;4(3):111-9 [17878515] Cancer Cell. 2007 Oct;12(4):303-12 [17936556] Front Biosci. 2008;13:71-84 [17981529] Oncogene. 2008 Jan 10;27(3):404-8 [17621273] Environ Mol Mutagen. 2008 Mar;49(2):142-54 [17973308] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20432 ER - TY - JOUR T1 - Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use. AN - 66806238; 19124692 AB - In ecological momentary assessment (EMA), participants electronically report their activities and moods in their daily environments in real time, enabling a truly prospective approach to the study of acute precipitants of behavioral events. Ecological momentary assessment has greatly enhanced the study of tobacco addiction, but its use has rarely been attempted in individuals with cocaine or heroin addiction. To prospectively monitor the acute daily life precipitants of craving for and use of cocaine and heroin. Cohort study. A volunteer sample of 114 cocaine- and heroin-abusing outpatients who were being treated with methadone provided EMA data on handheld electronic devices for 14 918 person-days (mean, 130.9; range, 6-189 days per participant). Of these outpatients, a total of 102 (63 men, 39 women) provided acute precraving and/or preuse data and were thus included in the present analyses. Changes in reports of mood and exposure to 12 putative drug-use triggers at random intervals during the 5 hours preceding each self-reported episode of drug craving or use, analyzed via repeated-measures logistic regression (generalized linear mixed models). During the 5 hours preceding cocaine use or heroin craving, most of the 12 putative triggers showed linear increases. Cocaine use was most robustly associated with increases in participants reporting that they "saw [the] drug" (P < .001), were "tempted to use out of the blue" (P < .001), "wanted to see what would happen if I used" (P < .001), and were in a good mood (P < .001). Heroin craving was most robustly associated with increases in reports of feeling sad (P < .001) or angry (P = .01). Cocaine craving and heroin use showed few reliable associations with any of the putative triggers assessed. These findings confirm that polydrug-abusing individuals can provide behavioral data in their daily environments using handheld electronic devices and that those data can reveal orderly patterns, including prospectively detectable harbingers of craving and use, which may differ across drugs. JF - Archives of general psychiatry AU - Epstein, David H AU - Willner-Reid, Jessica AU - Vahabzadeh, Massoud AU - Mezghanni, Mustapha AU - Lin, Jia-Ling AU - Preston, Kenzie L AD - National Institute on Drug Abuse Intramural Research Program, Treatment Section, Clinical Pharmacology and Therapeutics Branch, Baltimore, MD 21224, USA. depstein@intra.nida.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 88 EP - 94 VL - 66 IS - 1 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Methadone -- therapeutic use KW - Combined Modality Therapy KW - Humans KW - Counseling KW - Recurrence KW - Ambulatory Care KW - Prospective Studies KW - Token Economy KW - Adult KW - Narcotics -- therapeutic use KW - Middle Aged KW - Female KW - Male KW - Social Environment KW - Substance Withdrawal Syndrome -- rehabilitation KW - Motivation KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Heroin Dependence -- rehabilitation KW - Substance Withdrawal Syndrome -- psychology KW - Affect KW - Computers, Handheld KW - Heroin Dependence -- psychology KW - Cocaine-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66806238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+EEG+and+neuroscience&rft.atitle=EEG+and+cerebral+blood+flow+velocity+abnormalities+in+chronic+cocaine+users.&rft.au=Copersino%2C+Marc+L%3BHerning%2C+Ronald+I%3BBetter%2C+Warren%3BCadet%2C+Jean-Lud%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2009-01-01&rft.volume=40&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Clinical+EEG+and+neuroscience&rft.issn=15500594&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2009-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addiction. 2000 Jun;95(6):889-900 [10946438] Drug Alcohol Depend. 1998 Nov 1;52(3):183-92 [9839144] J Subst Abuse Treat. 2001 Sep;21(2):77-87 [11551736] Psychol Addict Behav. 2002 Sep;16(3):205-11 [12236455] J Abnorm Psychol. 2002 Nov;111(4):531-45 [12428767] Psychol Addict Behav. 2003 Mar;17(1):73-82 [12665084] Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20 [12402102] Psychopharmacology (Berl). 2003 Jul;168(1-2):31-41 [12721778] J Clin Psychol. 2004 Feb;60(2):179-88 [14724925] Psychol Rev. 2004 Jan;111(1):33-51 [14756584] J Consult Clin Psychol. 2004 Apr;72(2):192-201 [15065954] J Consult Clin Psychol. 1990 Apr;58(2):175-81 [2335634] Addict Behav. 1991;16(1-2):41-9 [2048457] J Consult Clin Psychol. 1996 Apr;64(2):366-79 [8871421] J Consult Clin Psychol. 1997 Feb;65(1):178-83 [9103747] Drug Alcohol Depend. 2005 Jun 1;78(3):275-81 [15893158] J Subst Abuse Treat. 2006 Mar;30(2):105-11 [16490673] Drug Alcohol Depend. 2006 Dec 1;85(3):221-35 [16730923] Schizophr Res. 2008 Jan;98(1-3):312-7 [17920245] Psychol Sci. 2000 Nov;11(6):446-53 [11202488] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1001/archgenpsychiatry.2008.509 ER - TY - JOUR T1 - Jupiter to earth: a statin helps people with normal LDL-C and high hs-CRP, but what does it mean? AN - 66802173; 19122109 AB - The JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) (N Engl J Med 2008; 359:2195-2207) compared rosuvastatin (Crestor) 20 mg daily vs placebo in apparently healthy people who had levels of low-density lipoprotein cholesterol (LDL-C) lower than 130 mg/dL but elevated levels (>or= 2 mg/L) of high-sensitivity C-reactive protein (hs-CRP). Rosuvastatin treatment lowered LDL-C levels by 50% and hs-CRP levels by 37%, accompanied by a 44% relative risk reduction in the composite end point of unstable angina, revascularization, and confirmed death from cardiovascular causes. In absolute terms, 95 people had to be treated over 2 years to prevent one event. There was, however, a higher incidence of diabetes in the rosuvastatin group. JF - Cleveland Clinic journal of medicine AU - Shishehbor, Mehdi H AU - Hazen, Stanley L AD - National Institutes of Health CTSA-KL2 Scholar, Department of Interventional Cardiology, Heart and Vascular Institute, Cleveland Clinic , Cleveland, OH 44195, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 37 EP - 44 VL - 76 IS - 1 KW - Cholesterol, LDL KW - 0 KW - Fluorobenzenes KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors KW - Pyrimidines KW - Sulfonamides KW - Rosuvastatin Calcium KW - 83MVU38M7Q KW - C-Reactive Protein KW - 9007-41-4 KW - Index Medicus KW - Humans KW - Aged KW - Male KW - Female KW - Pyrimidines -- adverse effects KW - Cholesterol, LDL -- blood KW - Sulfonamides -- adverse effects KW - Pyrimidines -- therapeutic use KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- adverse effects KW - Fluorobenzenes -- adverse effects KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors -- therapeutic use KW - Fluorobenzenes -- therapeutic use KW - Sulfonamides -- therapeutic use KW - C-Reactive Protein -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66802173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cleveland+Clinic+journal+of+medicine&rft.atitle=Jupiter+to+earth%3A+a+statin+helps+people+with+normal+LDL-C+and+high+hs-CRP%2C+but+what+does+it+mean%3F&rft.au=Shishehbor%2C+Mehdi+H%3BHazen%2C+Stanley+L&rft.aulast=Shishehbor&rft.aufirst=Mehdi&rft.date=2009-01-01&rft.volume=76&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Cleveland+Clinic+journal+of+medicine&rft.issn=1939-2869&rft_id=info:doi/10.3949%2Fccjm.75a.08105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-24 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Cardiol. 2001 Mar 8;87(5A):28B-32B [11256847] JAMA. 2001 Apr 4;285(13):1711-8 [11277825] Circulation. 2001 Apr 3;103(13):1813-8 [11282915] JAMA. 2001 Jul 4;286(1):64-70 [11434828] Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1712-9 [11701455] Int J Clin Pract. 2002 Jan-Feb;56(1):53-6 [11831837] JAMA. 2002 Jun 26;287(24):3215-22 [12076217] Eur Heart J. 2002 Dec;23(24):1931-7 [12473255] Circulation. 2003 Jan 28;107(3):391-7 [12551861] Circulation. 2003 Jan 28;107(3):499-511 [12551878] JAMA. 2003 Apr 2;289(13):1675-80 [12672736] Cleve Clin J Med. 2003 Jul;70(7):634-40 [12882386] Circulation. 2003 Jul 29;108(4):426-31 [12860913] Curr Probl Cardiol. 2003 May;28(5):317-47 [14614445] JAMA. 2004 Mar 3;291(9):1071-80 [14996776] Curr Atheroscler Rep. 2004 May;6(3):243-50 [15068750] N Engl J Med. 2004 Apr 1;350(14):1387-97 [15070788] N Engl J Med. 2004 Apr 8;350(15):1495-504 [15007110] N Engl J Med. 2004 Apr 8;350(15):1562-4 [15007111] Circulation. 2001 Jan 16;103(2):276-83 [11208689] Circulation. 2004 Jul 13;110(2):227-39 [15249516] JAMA. 2004 Sep 15;292(11):1307-16 [15337732] Expert Opin Drug Saf. 2004 Nov;3(6):547-57 [15500414] Lancet. 1996 Nov 16;348(9038):1339-42 [8918276] N Engl J Med. 1997 Apr 3;336(14):973-9 [9077376] Circulation. 1998 May 26;97(20):2007-11 [9610529] JAMA. 1998 May 27;279(20):1615-22 [9613910] Circulation. 1998 Aug 25;98(8):731-3 [9727541] N Engl J Med. 1999 Jul 8;341(2):70-6 [10395630] Circulation. 1999 Jul 20;100(3):230-5 [10411845] Am J Cardiol. 2004 Nov 1;94(9):1140-6 [15518608] N Engl J Med. 2005 Jan 6;352(1):20-8 [15635109] N Engl J Med. 2005 Jan 6;352(1):29-38 [15635110] N Engl J Med. 2005 Apr 7;352(14):1425-35 [15755765] Circ Res. 2005 Apr 15;96(7):714-6 [15774855] JAMA. 2005 May 11;293(18):2245-56 [15886380] Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1102-11 [15790935] Circulation. 2005 Jul 5;112(1):25-31 [15983251] N Engl J Med. 2005 Jul 7;353(1):93-6; author reply 93-6 [16003832] Circulation. 2005 Aug 16;112(7):1016-23 [16087790] Am J Cardiol. 2005 Sep 5;96(5A):24F-33F [16126020] Lancet. 2005 Oct 8;366(9493):1267-78 [16214597] J Am Coll Cardiol. 2005 Oct 18;46(8):1405-10 [16226162] J Am Coll Cardiol. 2005 Nov 15;46(10):1855-62 [16286171] JAMA. 2005 Nov 16;294(19):2437-45 [16287954] Am J Cardiol. 2006 Apr 17;97(8A):44C-51C [16581328] Am J Cardiol. 2006 Apr 17;97(8A):82C-85C [16581334] JAMA. 2006 Apr 5;295(13):1556-65 [16533939] Cleve Clin J Med. 2006 Aug;73(8):760-6 [16913201] Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):134-40 [17068284] Eur Heart J. 2007 Mar;28(6):664-72 [17242008] J Am Coll Cardiol. 2007 May 1;49(17):1753-62 [17466224] J Am Coll Cardiol. 2007 May 29;49(21):2129-38 [17531663] JAMA. 2008 Mar 19;299(11):1265-76 [18349088] J Am Coll Cardiol. 2008 Apr 29;51(17):1653-62 [18436117] J Am Coll Cardiol. 2008 Jul 1;52(1):24-32 [18582631] N Engl J Med. 2008 Aug 14;359(7):760; author reply 761 [18703482] N Engl J Med. 2008 Oct 30;359(18):1897-908 [18971492] Arch Intern Med. 2002 Apr 22;162(8):867-9 [11966336] N Engl J Med. 2008 Nov 20;359(21):2280-2 [18997195] N Engl J Med. 2008 Nov 20;359(21):2195-207 [18997196] N Engl J Med. 2008 Oct 30;359(18):1953-5 [18971498] N Engl J Med. 1999 Dec 9;341(24):1853-4; author reply 1854-5 [10610464] Adv Intern Med. 2000;45:391-418 [10635056] N Engl J Med. 2000 Mar 23;342(12):836-43 [10733371] Curr Cardiol Rep. 2000 Jul;2(4):269-73 [10953258] Clin Chem. 2001 Mar;47(3):403-11 [11238289] JAMA. 2001 May 16;285(19):2481-5 [11368701] JAMA. 2001 May 16;285(19):2486-97 [11368702] N Engl J Med. 2001 Jun 28;344(26):1959-65 [11430324] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3949/ccjm.75a.08105 ER - TY - JOUR T1 - Frontiers in addiction research: celebrating the 35th anniversary of the National Institute on Drug Abuse. Sponsor's foreword. AN - 66801377; 18789343 JF - Neuropharmacology AU - Shurtleff, David AU - Liu, Rita AU - Sasek, Cathrine AD - National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. dshurtle@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1 EP - 2 VL - 56 Suppl 1 SN - 0028-3908, 0028-3908 KW - Index Medicus KW - United States KW - Humans KW - National Institute on Drug Abuse (U.S.) KW - Biomedical Research -- trends KW - Biomedical Research -- methods KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66801377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Frontiers+in+addiction+research%3A+celebrating+the+35th+anniversary+of+the+National+Institute+on+Drug+Abuse.+Sponsor%27s+foreword.&rft.au=Shurtleff%2C+David%3BLiu%2C+Rita%3BSasek%2C+Cathrine&rft.aulast=Shurtleff&rft.aufirst=David&rft.date=2009-01-01&rft.volume=56+Suppl+1&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-15 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2008.08.009 ER - TY - JOUR T1 - LX211 (voclosporin) suppresses experimental uveitis and inhibits human T cells. AN - 66795572; 18708627 AB - To test the therapeutic effectiveness of voclosporin against experimental autoimmune uveoretinitis (EAU) in rats and to evaluate its effect on human T cells. EAU was induced by immunization with a uveitogenic protein. Voclosporin administration, by subcutaneous injection, began on day (d) 0 or d7 after immunization. Treatment effectiveness was evaluated in vivo using clinical EAU scoring (d7-d13) and histopathologic evaluation of enucleated eyes after experimental termination. Rodent lymphocytes were harvested from lymph nodes on d14 for antigen-specific proliferation assays. The effect of voclosporin on human T-cell proliferation and cytokine secretion was examined in vitro. Voclosporin prevented EAU development in rats receiving medium and high preventive doses, whereas high-dose voclosporin administration effectively treated EAU. Lymphocytes from animals treated with voclosporin had decreased antigen-specific proliferation in vitro compared with lymphocytes from untreated animals. No evidence of abnormal ocular histopathology was found in the eyes from animals that received high doses of therapeutic voclosporin. Using human T cells, voclosporin inhibited human T-cell proliferation up to 100-fold. Furthermore, voclosporin treatment of human T cells significantly reduced pan T-cell effector responses. Voclosporin effectively suppressed uveoretinitis in an animal model that imitates the human inflammatory ocular disease by inhibiting lymphocyte proliferation. In addition, voclosporin effectively inhibited human T-cell proliferation and function in vitro. The authors report the first evidence supporting the application of voclosporin to treat intraocular inflammation. JF - Investigative ophthalmology & visual science AU - Cunningham, Matthew A AU - Austin, Bobbie Ann AU - Li, Zhuqing AU - Liu, Baoying AU - Yeh, Steven AU - Chan, Chi-Chao AU - Anglade, Eddy AU - Velagaleti, Poonam AU - Nussenblatt, Robert B AD - National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 249 EP - 255 VL - 50 IS - 1 KW - Cytokines KW - 0 KW - Eye Proteins KW - Immunosuppressive Agents KW - Retinol-Binding Proteins KW - interstitial retinol-binding protein KW - voclosporin KW - 2PN063X6B1 KW - Cyclosporine KW - 83HN0GTJ6D KW - Index Medicus KW - Rats KW - Lymphocyte Activation -- drug effects KW - Animals KW - Rats, Inbred Lew KW - Humans KW - Treatment Outcome KW - Injections, Subcutaneous KW - Cytokines -- metabolism KW - Male KW - Uveitis -- prevention & control KW - Autoimmune Diseases -- prevention & control KW - Retinitis -- immunology KW - Retinitis -- prevention & control KW - Disease Models, Animal KW - Uveitis -- immunology KW - Retinitis -- chemically induced KW - Immunosuppressive Agents -- pharmacology KW - Cyclosporine -- pharmacology KW - Autoimmune Diseases -- chemically induced KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- immunology KW - Uveitis -- chemically induced KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66795572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=LX211+%28voclosporin%29+suppresses+experimental+uveitis+and+inhibits+human+T+cells.&rft.au=Cunningham%2C+Matthew+A%3BAustin%2C+Bobbie+Ann%3BLi%2C+Zhuqing%3BLiu%2C+Baoying%3BYeh%2C+Steven%3BChan%2C+Chi-Chao%3BAnglade%2C+Eddy%3BVelagaleti%2C+Poonam%3BNussenblatt%2C+Robert+B&rft.aulast=Cunningham&rft.aufirst=Matthew&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=1552-5783&rft_id=info:doi/10.1167%2Fiovs.08-1891 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2009-01-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Nephrol Hypertens. 1995 Nov;4(6):472-7 [8591053] Ren Physiol Biochem. 1995 May-Jun;18(3):128-39 [7542793] Ophthalmology. 1998 Nov;105(11):2028-34 [9818601] Ophthalmology. 1999 Apr;106(4):723-8 [10201592] Clin Exp Immunol. 1999 Sep;117(3):455-61 [10469047] Transpl Int. 2005 May;17(12):767-71 [15827754] J Nephrol. 2005 Jul-Aug;18(4):453-7 [16245254] J Am Acad Dermatol. 2006 Mar;54(3):472-8 [16488299] Int Ophthalmol Clin. 2006 Fall;46(4):105-22 [17060797] Br J Ophthalmol. 2007 Feb;91(2):237-42 [16987901] Ophthalmology. 2007 May;114(5):1000-6 [17467532] Nat Med. 2007 Jun;13(6):711-8 [17496900] Expert Opin Investig Drugs. 2007 Oct;16(10):1525-40 [17922618] Bone Marrow Transplant. 2008 Feb;41(3):293-302 [17982500] J Exp Med. 2008 Apr 14;205(4):799-810 [18391061] Transplant Proc. 2001 Feb-Mar;33(1-2):1048-51 [11267185] J Ocul Pharmacol Ther. 2001 Apr;17(2):181-7 [11324985] J Rheumatol. 2002 Aug;29(8):1646-52 [12180723] J Heart Lung Transplant. 2003 Dec;22(12):1343-52 [14672749] Br J Ophthalmol. 2004 Mar;88(3):412-6 [14977779] Mol Interv. 2004 Apr;4(2):97-107 [15087483] Methods Mol Med. 2004;102:395-419 [15286397] Transplantation. 2004 Sep 15;78(5):681-5 [15371668] J Clin Invest. 1981 Apr;67(4):1228-31 [7204576] Invest Ophthalmol Vis Sci. 1985 Feb;26(2):226-32 [3871750] Biochemistry. 1985 Jan 29;24(3):787-93 [4039604] Transplant Proc. 1988 Jun;20(3 Suppl 4):122-7 [3381266] Invest Ophthalmol Vis Sci. 1988 Aug;29(8):1265-71 [2458329] J Ocul Pharmacol. 1985 Winter;1(4):369-82 [3880086] J Autoimmun. 1990 Jun;3(3):247-55 [2397018] Autoimmunity. 1990;8(1):43-51 [1717008] Photochem Photobiol. 1991 Dec;54(6):1057-60 [1775528] Biochem Pharmacol. 1992 Mar 3;43(5):1021-4 [1313235] Am J Ophthalmol. 1994 Jul 15;118(1):39-45 [8023874] Br J Ophthalmol. 1996 Sep;80(9):844-8 [8962842] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1167/iovs.08-1891 ER - TY - JOUR T1 - Imaging dopamine's role in drug abuse and addiction. AN - 66788233; 18617195 AB - Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we describe PET imaging studies that investigate dopamine's involvement in drug abuse in the human brain. In humans the reinforcing effects of drugs are associated with large and fast increases in extracellular dopamine, which mimic those induced by physiological dopamine cell firing but are more intense and protracted. Since dopamine cells fire in response to salient stimuli, supraphysiological activation by drugs is experienced as highly salient (driving attention, arousal, conditioned learning and motivation) and with repeated drug use may raise the thresholds required for dopamine cell activation and signaling. Indeed, imaging studies show that drug abusers have marked decreases in dopamine D2 receptors and in dopamine release. This decrease in dopamine function is associated with reduced regional activity in orbitofrontal cortex (involved in salience attribution; its disruption results in compulsive behaviors), cingulate gyrus (involved in inhibitory control; its disruption results in impulsivity) and dorsolateral prefrontal cortex (involved in executive function; its disruption results in impaired regulation of intentional actions). In parallel, conditioning triggered by drugs leads to enhanced dopamine signaling when exposed to conditioned cues, which then drives the motivation to procure the drug in part by activation of prefrontal and striatal regions. These findings implicate deficits in dopamine activity-inked with prefrontal and striatal deregulation-in the loss of control and compulsive drug intake that results when the addicted person takes the drugs or is exposed to conditioned cues. The decreased dopamine function in addicted individuals also reduces their sensitivity to natural reinforcers. Therapeutic interventions aimed at restoring brain dopaminergic tone and activity of cortical projection regions could improve prefrontal function, enhance inhibitory control and interfere with impulsivity and compulsive drug administration while helping to motivate the addicted person to engage in non-drug related behaviors. JF - Neuropharmacology AU - Volkow, N D AU - Fowler, J S AU - Wang, G J AU - Baler, R AU - Telang, F AD - National Institute on Drug Abuse, NIH, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 3 EP - 8 VL - 56 Suppl 1 SN - 0028-3908, 0028-3908 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Brain -- physiopathology KW - Animals KW - Humans KW - Brain -- metabolism KW - Substance-Related Disorders -- pathology KW - Diagnostic Imaging KW - Dopamine -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66788233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Imaging+dopamine%27s+role+in+drug+abuse+and+addiction.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWang%2C+G+J%3BBaler%2C+R%3BTelang%2C+F&rft.aulast=Volkow&rft.aufirst=N&rft.date=2009-01-01&rft.volume=56+Suppl+1&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.05.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-15 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2002 Oct 10;36(2):241-63 [12383780] Behav Pharmacol. 2002 Sep;13(5-6):355-66 [12394411] Psychiatry Res. 2002 Dec 30;116(3):163-72 [12477600] Neurobiol Learn Mem. 2002 Nov;78(3):610-24 [12559839] Neurotoxicology. 2003 Jan;24(1):75-82 [12564384] J Clin Invest. 2003 May;111(10):1444-51 [12750391] Trends Neurosci. 2003 Aug;26(8):423-8 [12900173] J Neurosci. 2003 Sep 3;23(22):8092-7 [12954871] Am J Psychiatry. 2003 Nov;160(11):1909-18 [14594733] J Neurosci. 2003 Dec 10;23(36):11461-8 [14673011] Ann N Y Acad Sci. 2003 Nov;1003:241-9 [14684450] Neuropsychopharmacology. 2004 Jun;29(6):1190-202 [15010698] Am J Psychiatry. 2004 Jul;161(7):1211-8 [15229053] Synapse. 2004 Nov;54(2):65-71 [15352131] Am J Psychiatry. 2004 Oct;161(10):1783-9 [15465974] Nature. 2005 Oct 13;437(7061):1027-31 [16222299] Biol Psychiatry. 2005 Nov 15;58(10):779-86 [16018986] Eur J Pharmacol. 2005 Dec 5;526(1-3):77-88 [16310768] Biol Psychiatry. 2006 May 15;59(10):966-74 [16616726] Handb Exp Pharmacol. 2006;(175):215-32 [16722238] J Neurosci. 2006 Jun 14;26(24):6583-8 [16775146] Am J Psychiatry. 2006 Sep;163(9):1639-41 [16946193] Arch Gen Psychiatry. 2006 Sep;63(9):999-1008 [16953002] Neuroimage. 2006 Oct 1;32(4):1782-92 [16757181] Psychopharmacology (Berl). 2006 Oct;188(3):364-73 [16953385] Neuropsychopharmacology. 2006 Dec;31(12):2716-27 [16971900] Neuroimage. 2007 Feb 1;34(3):1182-90 [17126039] J Neurophysiol. 2007 Feb;97(2):1621-32 [17122317] Am J Psychiatry. 2007 Apr;164(4):622-9 [17403976] Neuron. 2007 Apr 19;54(2):183-6 [17442239] Addiction. 2007 Apr;102 Suppl 1:16-32 [17493050] Synapse. 2007 Aug;61(8):637-45 [17492764] Pharmacol Biochem Behav. 2007 May;87(1):20-9 [17490738] Nat Neurosci. 2007 Aug;10(8):1020-8 [17603481] Neuropsychologia. 2007 Sep 20;45(12):2744-54 [17544015] Arch Gen Psychiatry. 2007 Aug;64(8):932-40 [17679638] Arch Gen Psychiatry. 2007 Oct;64(10):1145-52 [17909126] Nat Rev Neurosci. 2007 Nov;8(11):844-58 [17948030] Arch Neurol. 2007 Nov;64(11):1575-9 [17998440] J Neurosci. 2007 Nov 14;27(46):12700-6 [18003850] J Clin Pharmacol. 2007 Dec;47(12):1476-88 [17962423] Neuroimage. 2008 Feb 1;39(3):1266-73 [18024160] Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):274-9 [17900774] Am J Psychiatry. 2008 Apr;165(4):507-14 [18316420] Int J Neuropsychopharmacol. 2008 May;11(3):413-7 [17949514] Psychopharmacology (Berl). 2008 May;197(4):549-56 [18270689] J Neurosci. 2005 Apr 13;25(15):3932-9 [15829645] Neuroscience. 2000;96(4):651-6 [10727783] Cereb Cortex. 2000 Mar;10(3):272-84 [10731222] Cereb Cortex. 2000 Mar;10(3):284-94 [10731223] Cereb Cortex. 2000 Mar;10(3):318-25 [10731226] Life Sci. 2000 Aug 11;67(12):1507-15 [10983846] Addiction. 2000 Aug;95 Suppl 2:S119-28 [11002907] Mt Sinai J Med. 2000 Oct-Nov;67(5-6):381-7 [11064488] Biol Psychiatry. 2001 Jan 15;49(2):81-96 [11164755] J Neurosci. 2001 Jan 15;21(2):RC121 [11160455] Nature. 2001 Jul 5;412(6842):43-8 [11452299] J Neurochem. 2001 Sep;78(5):1094-103 [11553683] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] Nat Neurosci. 2002 Feb;5(2):169-74 [11802171] Arch Gen Psychiatry. 2002 Mar;59(3):250-61 [11879163] Neuropharmacology. 2004;47 Suppl 1:33-46 [15464124] J Exp Anal Behav. 1973 Jul;20(1):119-29 [4197505] Neuroscience. 1984 Aug;12(4):1201-12 [6148716] Proc Natl Acad Sci U S A. 1988 Jul;85(14):5274-8 [2899326] Science. 1988 Nov 4;242(4879):715-23 [2903550] Arch Gen Psychiatry. 1990 Jun;47(6):567-74 [2350209] Synapse. 1993 Jun;14(2):169-77 [8101394] Behav Brain Res. 1993 Jun 30;55(2):243-52 [8395182] Psychopharmacology (Berl). 1994 Nov;116(3):285-90 [7892418] Arch Gen Psychiatry. 1995 Jun;52(6):456-63 [7771915] Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10388-92 [8816810] Neuropsychopharmacology. 1996 Mar;14(3):159-68 [8866699] Alcohol Clin Exp Res. 1996 Dec;20(9):1594-8 [8986209] Neuropsychopharmacology. 1997 Feb;16(2):174-82 [9015800] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2787-8 [9096295] Nature. 1997 Apr 24;386(6627):830-3 [9126741] Am J Psychiatry. 1997 Sep;154(9):1209-13 [9286178] Science. 1997 Oct 3;278(5335):52-8 [9311926] Neuropsychopharmacology. 1997 Dec;17(6):402-9 [9397428] Am J Psychiatry. 1998 Jun;155(6):832-4 [9619159] Mol Psychiatry. 1999 Mar;4(2):189-91, 104-5 [10208452] Synapse. 1999 Sep 15;33(4):268-73 [10421707] Am J Psychiatry. 1999 Sep;156(9):1440-3 [10484959] Am J Psychiatry. 2005 Aug;162(8):1403-13 [16055761] Am J Psychiatry. 2005 Aug;162(8):1515-20 [16055774] Neuroimage. 2002 Jun;16(2):331-48 [12030820] Synapse. 2002 Nov;46(2):79-82 [12211085] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2008.05.022 ER - TY - JOUR T1 - Psychostimulant treatment and the developing cortex in attention deficit hyperactivity disorder. AN - 66787712; 18794206 AB - While there has been considerable concern over possible adverse effects of psychostimulants on brain development, this issue has not been examined in a prospective study. The authors sought to determine prospectively whether psychostimulant treatment for attention deficit hyperactivity disorder (ADHD) was associated with differences in the development of the cerebral cortex during adolescence. Change in cortical thickness was estimated from two neuroanatomic MRI scans in 43 youths with ADHD. The mean age at the first scan was 12.5 years, and at the second scan, 16.4 years. Nineteen patients not treated with psychostimulants between the scans were compared with an age-matched group of 24 patients who were treated with psychostimulants. Further comparison was made against a template derived from 620 scans of 294 typically developing youths without ADHD. Adolescents taking psychostimulants differed from those not taking psychostimulants in the rate of change of the cortical thickness in the right motor strip, the left middle/inferior frontal gyrus, and the right parieto-occipital region. The group difference was due to more rapid cortical thinning in the group not taking psychostimulants (mean cortical thinning of 0.16 mm/year [SD=0.17], compared with 0.03 mm/year [SD=0.11] in the group taking psychostimulants). Comparison against the typically developing cohort without ADHD showed that cortical thinning in the group not taking psychostimulants was in excess of age-appropriate rates. The treatment groups did not differ in clinical outcome, however. These findings show no evidence that psychostimulants were associated with slowing of overall growth of the cortical mantle. JF - The American journal of psychiatry AU - Shaw, Philip AU - Sharp, Wendy S AU - Morrison, Meaghan AU - Eckstrand, Kristen AU - Greenstein, Deanna K AU - Clasen, Liv S AU - Evans, Alan C AU - Rapoport, Judith L AD - Child Psychiatry Branch, Bldg. 10, Center Dr., NIMH, Bethesda, MD 20892, USA. shawp@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 58 EP - 63 VL - 166 IS - 1 KW - Amphetamines KW - 0 KW - Central Nervous System Stimulants KW - Methylphenidate KW - 207ZZ9QZ49 KW - Pemoline KW - 7GAQ2332NK KW - Abridged Index Medicus KW - Index Medicus KW - Magnetic Resonance Imaging KW - Young Adult KW - Pemoline -- adverse effects KW - Humans KW - Amphetamines -- adverse effects KW - Methylphenidate -- therapeutic use KW - Child KW - Pemoline -- therapeutic use KW - Amphetamines -- therapeutic use KW - Methylphenidate -- adverse effects KW - Follow-Up Studies KW - Adolescent KW - Female KW - Male KW - Attention Deficit Disorder with Hyperactivity -- psychology KW - Attention Deficit Disorder with Hyperactivity -- diagnosis KW - Cerebral Cortex -- drug effects KW - Cerebral Cortex -- pathology KW - Central Nervous System Stimulants -- therapeutic use KW - Central Nervous System Stimulants -- adverse effects KW - Attention Deficit Disorder with Hyperactivity -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66787712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Psychostimulant+treatment+and+the+developing+cortex+in+attention+deficit+hyperactivity+disorder.&rft.au=Shaw%2C+Philip%3BSharp%2C+Wendy+S%3BMorrison%2C+Meaghan%3BEckstrand%2C+Kristen%3BGreenstein%2C+Deanna+K%3BClasen%2C+Liv+S%3BEvans%2C+Alan+C%3BRapoport%2C+Judith+L&rft.aulast=Shaw&rft.aufirst=Philip&rft.date=2009-01-01&rft.volume=166&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=1535-7228&rft_id=info:doi/10.1176%2Fappi.ajp.2008.08050781 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-02 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurosci Biobehav Rev. 2006;30(8):1225-45 [17161238] J Am Acad Child Adolesc Psychiatry. 2006 Nov;45(11):1304-13 [17023868] Biol Psychiatry. 2007 Jun 15;61(12):1361-9 [16950217] Neuroimage. 2007 Jul 15;36(4):1065-73 [17513132] Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19649-54 [18024590] J Am Acad Child Adolesc Psychiatry. 2000 Jan;39(1):59-66 [10638068] J Neurosci. 2000 Mar 15;20(6):RC65 [10704519] Neuroimage. 2000 Sep;12(3):340-56 [10944416] JAMA. 2002 Oct 9;288(14):1740-8 [12365958] J Am Acad Child Adolesc Psychiatry. 2002 Nov;41(11):1306-14 [12410072] IEEE Trans Med Imaging. 2002 Oct;21(10):1280-91 [12585710] Biol Psychiatry. 2003 Dec 15;54(12):1310-1 [14675793] Pediatrics. 2004 Apr;113(4):762-9 [15060225] Am J Psychiatry. 2004 Nov;161(11):1990-7 [15514398] J Abnorm Child Psychol. 1975;3(3):217-29 [1214032] Arch Gen Psychiatry. 1983 Jun;40(6):688-93 [6847336] Neuropsychopharmacology. 1989 Dec;2(4):255-63 [2692588] Biol Psychiatry. 1992 Apr 15;31(8):794-807 [1643194] J Child Psychol Psychiatry. 1993 Jul;34(5):785-804 [8340445] IEEE Trans Med Imaging. 1998 Feb;17(1):87-97 [9617910] Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14494-9 [9826728] Neuroimage. 2005 Jan 1;24(1):163-73 [15588607] Nature. 2006 Mar 30;440(7084):676-9 [16572172] J Neurosci. 2006 Apr 26;26(17):4567-76 [16641236] Arch Gen Psychiatry. 2006 May;63(5):540-9 [16651511] Neurology. 2006 Sep 26;67(6):1023-7 [17000972] Am J Psychiatry. 2007 Apr;164(4):647-55 [17403979] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1176/appi.ajp.2008.08050781 ER - TY - JOUR T1 - Ventral tegmental glutamate: a role in stress-, cue-, and cocaine-induced reinstatement of cocaine-seeking. AN - 66787498; 18598707 AB - Ventral tegmental dopamine neurons are activated by primary rewards and, when such rewards are predictable' by reward-predicting stimuli. Glutamatergic input to the ventral tegmental area contributes to this activation: in animals trained to self-administer cocaine, cocaine-predictive cues trigger ventral tegmental glutamate release and dopaminergic activation. Mild footshock stress similarly causes glutamate release and dopaminergic activation in cocaine-trained but not cocaine-naïve animals. The ability of cocaine-predictive and stress-associated cues to activate the dopamine system and to trigger cocaine craving appears to be related to changes in the ability of glutamate to activate dopaminergic neurons, changes known to be caused by experience with stress or with drugs of abuse. JF - Neuropharmacology AU - Wise, Roy A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes on Health, Department of Health and Human Services, 251 Bayview Blvd., Baltimore, MD 21224, USA. rwise@intra.nida.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 174 EP - 176 VL - 56 Suppl 1 SN - 0028-3908, 0028-3908 KW - Glutamic Acid KW - 3KX376GY7L KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Humans KW - Cocaine -- administration & dosage KW - Glutamic Acid -- metabolism KW - Cocaine-Related Disorders -- pathology KW - Cocaine-Related Disorders -- psychology KW - Cues KW - Ventral Tegmental Area -- metabolism KW - Cocaine-Related Disorders -- etiology KW - Ventral Tegmental Area -- drug effects KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66787498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Ventral+tegmental+glutamate%3A+a+role+in+stress-%2C+cue-%2C+and+cocaine-induced+reinstatement+of+cocaine-seeking.&rft.au=Wise%2C+Roy+A&rft.aulast=Wise&rft.aufirst=Roy&rft.date=2009-01-01&rft.volume=56+Suppl+1&rft.issue=&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/10.1016%2Fj.neuropharm.2008.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-15 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1983 Aug 19;221(4612):773-5 [6879176] Can J Psychol. 1977 Dec;31(4):195-203 [608135] Psychopharmacology (Berl). 1984;84(2):167-73 [6438676] J Chem Neuroanat. 1989 Sep-Oct;2(5):285-98 [2572241] Pharmacol Biochem Behav. 1989 Dec;34(4):899-904 [2623043] J Comp Neurol. 1992 Jun 8;320(2):145-60 [1377716] Neuroscience. 1994 Aug;61(4):851-65 [7530817] J Neurochem. 1995 Sep;65(3):1407-10 [7643120] Psychopharmacology (Berl). 1995 Jul;120(1):10-20 [7480530] Psychopharmacology (Berl). 1995 Nov;122(2):194-7 [8848536] Science. 1997 Mar 14;275(5306):1593-9 [9054347] J Neurochem. 1998 Apr;70(4):1497-502 [9523566] J Neurochem. 1998 Apr;70(4):1503-12 [9523567] J Neurophysiol. 1998 Jul;80(1):1-27 [9658025] J Neurosci. 1998 Aug 15;18(16):6492-500 [9698337] Synapse. 1999 Mar 15;31(4):241-9 [10051104] J Neurosci. 2005 May 11;25(19):4725-32 [15888648] J Neurosci. 2005 Jun 1;25(22):5389-96 [15930388] Eur J Neurosci. 2007 Jan;25(1):106-18 [17241272] Neuroscience. 2007 May 25;146(3):1259-74 [17391856] J Neurosci. 2007 May 23;27(21):5730-43 [17522317] Psychopharmacology (Berl). 2007 Aug;193(2):283-94 [17437087] J Neurosci. 2007 Sep 26;27(39):10546-55 [17898226] J Comp Neurol. 2008 Feb 1;506(4):616-26 [18067140] J Comp Neurol. 2008 Jul 20;509(3):302-18 [18478589] J Neurosci. 2000 Feb 15;20(4):1635-42 [10662853] J Comp Neurol. 2000 Dec 11;428(2):191-212 [11064361] Neuroscience. 2000;101(1):115-29 [11068141] Eur J Neurosci. 2001 Feb;13(4):819-28 [11207817] Nature. 2001 May 31;411(6837):583-7 [11385572] J Endocrinol. 2002 Oct;175(1):89-97 [12379493] Neuron. 2003 Feb 20;37(4):577-82 [12597856] J Comp Neurol. 2003 Apr 28;459(2):142-55 [12640666] Neuron. 2003 Jul 31;39(3):401-7 [12895416] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Curr Opin Pharmacol. 2004 Feb;4(1):23-9 [15018835] Nat Rev Neurosci. 2004 Jun;5(6):483-94 [15152198] Science. 1975 Feb 14;187(4176):547-9 [1114313] Pavlov J Biol Sci. 1976 Oct-Dec;11(4):222-36 [1033507] Pharmacol Biochem Behav. 1977 Jun;6(6):615-20 [122445] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuropharm.2008.06.008 ER - TY - JOUR T1 - Pharmacology and antifungal properties of anidulafungin, a new echinocandin. AN - 66786178; 19113794 AB - Anidulafungin is the third echinocandin antifungal agent to receive approval from the United States Food and Drug Administration. It is indicated for the treatment of esophageal candidiasis, candidemia, and other candidal infections. Anidulafungin is fungicidal against Candida species, including Candida glabrata and isolates resistant to azoles and polyenes. The drug's efficacy is comparable to that of fluconazole for the treatment of esophageal candidiasis, and it is effective in patients with invasive candidiasis and candidemia. Anidulafungin is distinct among the echinocandins in that it undergoes slow, nonenzymatic chemical degradation. As a consequence, impairments in renal or hepatic function do not substantially alter its pharmacokinetics. In addition, anidulafungin has not demonstrated any drug-drug interactions because it is not a substrate, inhibitor, or inducer of the cytochrome P450 enzyme system. Anidulafungin is well tolerated in adults and pediatric patients, with few reported adverse drug events. The safety, tolerability, and potent fungicidal activity of anidulafungin against Candida species make it a reasonable alternative in the treatment of patients with serious candidal infections. JF - Pharmacotherapy AU - Estes, Kristina E AU - Penzak, Scott R AU - Calis, Karim Anton AU - Walsh, Thomas J AD - Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 17 EP - 30 VL - 29 IS - 1 KW - Antifungal Agents KW - 0 KW - Echinocandins KW - anidulafungin KW - 9HLM53094I KW - Index Medicus KW - Drug Costs KW - Animals KW - Drug Interactions KW - Humans KW - Esophageal Diseases -- drug therapy KW - Drug Resistance, Fungal KW - Clinical Trials as Topic KW - Esophageal Diseases -- metabolism KW - Candidiasis -- drug therapy KW - Echinocandins -- therapeutic use KW - Antifungal Agents -- pharmacology KW - Echinocandins -- pharmacokinetics KW - Echinocandins -- pharmacology KW - Echinocandins -- chemistry KW - Echinocandins -- adverse effects KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66786178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Pharmacology+and+antifungal+properties+of+anidulafungin%2C+a+new+echinocandin.&rft.au=Estes%2C+Kristina+E%3BPenzak%2C+Scott+R%3BCalis%2C+Karim+Anton%3BWalsh%2C+Thomas+J&rft.aulast=Estes&rft.aufirst=Kristina&rft.date=2009-01-01&rft.volume=29&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=1875-9114&rft_id=info:doi/10.1592%2Fphco.29.1.17 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-02 N1 - Date created - 2008-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1592/phco.29.1.17 ER - TY - JOUR T1 - Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. AN - 66785444; 19117861 AB - Our objectives were to identify factors associated with the duration of the first antibiotic course initiated in the first 3 postnatal days and to assess associations between the duration of the initial antibiotic course and subsequent necrotizing enterocolitis or death in extremely low birth weight infants with sterile initial postnatal culture results. We conducted a retrospective cohort analysis of extremely low birth weight infants admitted to tertiary centers in 1998-2001. We defined initial empirical antibiotic treatment duration as continuous days of antibiotic therapy started in the first 3 postnatal days with sterile culture results. We used descriptive statistics to characterize center practice, bivariate analyses to identify factors associated with prolonged empirical antibiotic therapy (> or =5 days), and multivariate analyses to evaluate associations between therapy duration, prolonged empirical therapy, and subsequent necrotizing enterocolitis or death. Of 5693 extremely low birth weight infants admitted to 19 centers, 4039 (71%) survived >5 days, received initial empirical antibiotic treatment, and had sterile initial culture results through the first 3 postnatal days. The median therapy duration was 5 days (range: 1-36 days); 2147 infants (53%) received prolonged empirical therapy (center range: 27%-85%). Infants who received prolonged therapy were less mature, had lower Apgar scores, and were more likely to be black. In multivariate analyses adjusted for these factors and center, prolonged therapy was associated with increased odds of necrotizing enterocolitis or death and of death. Each empirical treatment day was associated with increased odds of death, necrotizing enterocolitis, and the composite measure of necrotizing enterocolitis or death. Prolonged initial empirical antibiotic therapy may be associated with increased risk of necrotizing enterocolitis or death and should be used with caution. JF - Pediatrics AU - Cotten, C Michael AU - Taylor, Sarah AU - Stoll, Barbara AU - Goldberg, Ronald N AU - Hansen, Nellie I AU - Sánchez, Pablo J AU - Ambalavanan, Namasivayam AU - Benjamin, Daniel K AU - NICHD Neonatal Research Network AD - Department of Pediatrics, Duke University, Durham, NC 27710, USA. cotte010@mc.duke.edu ; NICHD Neonatal Research Network Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 58 EP - 66 VL - 123 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Prospective Studies KW - Empirical Research KW - Risk Factors KW - Humans KW - Cohort Studies KW - Retrospective Studies KW - Infant, Newborn KW - Mortality -- trends KW - Enterocolitis, Necrotizing -- mortality KW - Infant, Premature, Diseases -- mortality KW - Anti-Bacterial Agents -- adverse effects KW - Infant, Extremely Low Birth Weight KW - Anti-Bacterial Agents -- administration & dosage KW - Infant, Premature, Diseases -- chemically induced KW - Enterocolitis, Necrotizing -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66785444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Prolonged+duration+of+initial+empirical+antibiotic+treatment+is+associated+with+increased+rates+of+necrotizing+enterocolitis+and+death+for+extremely+low+birth+weight+infants.&rft.au=Cotten%2C+C+Michael%3BTaylor%2C+Sarah%3BStoll%2C+Barbara%3BGoldberg%2C+Ronald+N%3BHansen%2C+Nellie+I%3BS%C3%A1nchez%2C+Pablo+J%3BAmbalavanan%2C+Namasivayam%3BBenjamin%2C+Daniel+K%3BNICHD+Neonatal+Research+Network&rft.aulast=Cotten&rft.aufirst=C&rft.date=2009-01-01&rft.volume=123&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/10.1542%2Fpeds.2007-3423 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2009-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pediatrics. 2000 Mar;105(3 Pt 1):523-7 [10699103] N Engl J Med. 2008 Mar 6;358(10):991-8 [18256387] Pediatrics. 2003 Mar;111(3):529-34 [12612232] Infect Control Hosp Epidemiol. 2003 Sep;24(9):662-6 [14510248] Clin Microbiol Rev. 2004 Jul;17(3):638-80, table of contents [15258097] Cell. 2004 Jul 23;118(2):229-41 [15260992] Pediatr Clin North Am. 1986 Feb;33(1):179-201 [3081865] J Clin Microbiol. 1989 May;27(5):1068-71 [2745679] Mycoses. 1990 Jan;33(1):20-3 [2342516] J Pediatr. 1991 Oct;119(4):630-8 [1919897] Arch Dis Child Fetal Neonatal Ed. 1995 Jul;73(1):F32-6 [7552593] J Pediatr. 1996 Aug;129(2):275-8 [8765627] Arch Dis Child Fetal Neonatal Ed. 1997 Mar;76(2):F101-7 [9135288] Arch Dis Child Fetal Neonatal Ed. 1999 May;80(3):F167-73 [10212075] Clin Infect Dis. 1999 Aug;29(2):253-8 [10476721] Pediatrics. 2005 Mar;115(3):696-703 [15741374] Pediatr Infect Dis J. 2005 Jul;24(7):635-9 [15999007] Cell. 2005 Jul 15;122(1):107-18 [16009137] Pediatrics. 2005 Aug;116(2):400-6 [16061595] Pediatr Res. 2005 Oct;58(4):625-8 [16189184] Pediatrics. 2005 Dec;116(6):1367-73 [16322160] Pediatrics. 2006 Jan;117(1):67-74 [16396862] Arch Dis Child Fetal Neonatal Ed. 2006 May;91(3):F208-12 [16632649] Pediatrics. 2006 Jun;117(6):1979-87 [16740839] J Immunol. 2006 Sep 1;177(5):3273-82 [16920968] N Engl J Med. 2008 Mar 6;358(10):988-9 [18256386] Pediatrics. 2001 Jan;107(1):E1 [11134465] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1542/peds.2007-3423 ER - TY - JOUR T1 - Enhancement of DNA tumor vaccine efficacy by gene gun-mediated codelivery of threshold amounts of plasmid-encoded helper antigen. AN - 66784619; 18832136 AB - Nucleic acid-based vaccines are effective in infectious disease models but have yielded disappointing results in tumor models when tumor-associated self-antigens are used. Incorporation of helper epitopes from foreign antigens into tumor vaccines might enhance the immunogenicity of DNA vaccines without increasing toxicity. However, generation of fusion constructs encoding both tumor and helper antigens may be difficult, and resulting proteins have unpredictable physical and immunologic properties. Furthermore, simultaneous production of equal amounts of highly immunogenic helper and weakly immunogenic tumor antigens in situ could favor development of responses against the helper antigen rather than the antigen of interest. We assessed the ability of 2 helper antigens (beta-galactosidase or fragment C of tetanus toxin) encoded by one plasmid to augment responses to a self-antigen (lymphoma-associated T-cell receptor) encoded by a separate plasmid after codelivery into skin by gene gun. This approach allowed adjustment of the relative ratios of helper and tumor antigen plasmids to optimize helper effects. Incorporation of threshold (minimally immunogenic) amounts of helper antigen plasmid into a DNA vaccine regimen dramatically increased T cell-dependent protective immunity initiated by plasmid-encoded tumor-associated T-cell receptor antigen. This simple strategy can easily be incorporated into future vaccine trials in experimental animals and possibly in humans. JF - Blood AU - Leitner, Wolfgang W AU - Baker, Matthew C AU - Berenberg, Thomas L AU - Lu, Michael C AU - Yannie, P Josef AU - Udey, Mark C AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 37 EP - 45 VL - 113 IS - 1 KW - Antigens, Neoplasm KW - 0 KW - Cancer Vaccines KW - Epitopes, T-Lymphocyte KW - Peptide Fragments KW - Receptors, Antigen, T-Cell, alpha-beta KW - Tetanus Toxin KW - Vaccines, DNA KW - tetanus toxin fragment C KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cell Line, Tumor KW - Epitopes, T-Lymphocyte -- immunology KW - Mice KW - Plasmids -- pharmacology KW - Epitopes, T-Lymphocyte -- genetics KW - Transfection KW - Antibody Formation -- immunology KW - Receptors, Antigen, T-Cell, alpha-beta -- immunology KW - Kidney -- cytology KW - Mice, Inbred C57BL KW - Antigens, Neoplasm -- immunology KW - Receptors, Antigen, T-Cell, alpha-beta -- genetics KW - T-Lymphocytes -- immunology KW - Female KW - Cricetinae KW - Tetanus Toxin -- immunology KW - Cancer Vaccines -- pharmacology KW - Vaccines, DNA -- immunology KW - Cancer Vaccines -- immunology KW - Peptide Fragments -- genetics KW - Vaccines, DNA -- pharmacology KW - Tetanus Toxin -- genetics KW - Biolistics -- methods KW - beta-Galactosidase -- genetics KW - Lymphoma, T-Cell -- immunology KW - beta-Galactosidase -- immunology KW - Peptide Fragments -- immunology KW - Lymphoma, T-Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66784619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Enhancement+of+DNA+tumor+vaccine+efficacy+by+gene+gun-mediated+codelivery+of+threshold+amounts+of+plasmid-encoded+helper+antigen.&rft.au=Leitner%2C+Wolfgang+W%3BBaker%2C+Matthew+C%3BBerenberg%2C+Thomas+L%3BLu%2C+Michael+C%3BYannie%2C+P+Josef%3BUdey%2C+Mark+C&rft.aulast=Leitner&rft.aufirst=Wolfgang&rft.date=2009-01-01&rft.volume=113&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-01-136267 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Feb 1;162(3):1749-55 [9973438] J Immunother. 1998 Nov;21(6):399-408 [9807734] J Virol. 1999 Mar;73(3):2280-7 [9971811] Vaccine. 1999 Feb 12;17(6):589-96 [10075166] Nat Med. 1999 Jul;5(7):823-7 [10395329] Vaccine. 2005 Jan 19;23(9):1114-25 [15629354] Med Hypotheses. 2006;67(1):71-4 [16513289] Intervirology. 2006;49(4):249-52 [16601357] Trends Mol Med. 2006 May;12(5):216-22 [16621717] J Clin Oncol. 2006 Jul 1;24(19):3107-12 [16754937] Adv Cancer Res. 2006;95:203-47 [16860659] Arch Virol. 2006 Nov;151(11):2133-48 [16791442] Clin Immunol. 2006 Nov;121(2):177-85 [16914381] J Virol. 2006 Dec;80(24):11991-7 [17005652] Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):540-9 [17255276] Scand J Immunol. 2007 Mar;65(3):240-8 [17309778] Vaccine. 2007 May 10;25(19):3731-41 [17350735] Curr Cancer Drug Targets. 2007 May;7(3):259-71 [17504123] Cancer Res. 2007 Jul 1;67(13):6459-67 [17616707] Cancer Res. 2007 Sep 1;67(17):7945-7 [17804699] Cancer Immunol Immunother. 2008 Nov;57(11):1635-45 [18386000] J Immunol. 2001 May 1;166(9):5366-73 [11313372] Vaccine. 1999 Dec 10;18(9-10):815-24 [10580194] Cancer Res. 2000 Jan 1;60(1):51-5 [10646851] J Immunol. 2000 Jul 15;165(2):869-77 [10878361] Curr Oncol Rep. 2000 Jan;2(1):38-47 [11122823] Vaccine. 2001 Mar 21;19(17-19):2647-56 [11257404] J Immunol. 2001 Aug 1;167(3):1558-65 [11466377] Curr Pharm Des. 2001 Nov;7(16):1641-67 [11562304] J Immunol. 2001 Nov 15;167(10):5549-57 [11698425] Dev Biol (Basel). 2000;104:181-5 [11713818] Cancer Res. 2002 Mar 15;62(6):1757-60 [11912151] Nat Med. 2003 Jan;9(1):33-9 [12496961] J Mol Med (Berl). 2003 Feb;81(2):71-86 [12601523] Hum Gene Ther. 2003 May 20;14(8):709-14 [12804135] J Immunol. 2003 Dec 15;171(12):6396-405 [14662838] J Immunol. 2004 Jan 15;172(2):929-36 [14707065] Expert Rev Vaccines. 2004 Apr;3(2):151-62 [15056041] Vaccine. 2004 May 7;22(15-16):2031-41 [15121317] Expert Opin Biol Ther. 2004 Jun;4(6):889-900 [15174971] DNA Cell Biol. 2004 Jun;23(6):395-402 [15231073] Nat Immunol. 2004 Nov;5(11):1143-8 [15475958] Infect Immun. 2004 Nov;72(11):6519-27 [15501783] J Immunol Methods. 1984 Mar 16;67(2):321-36 [6707474] J Immunol Methods. 1987 Apr 2;98(1):11-22 [2435806] J Immunol. 1988 Sep 15;141(6):2168-74 [3049800] Infect Immun. 1990 Apr;58(4):1004-9 [2318526] J Virol. 1996 Nov;70(11):7773-82 [8892898] J Immunol. 1997 Dec 1;159(11):5516-27 [9548492] J Immunol. 1997 Dec 15;159(12):6112-9 [9550412] J Exp Med. 1998 Sep 21;188(6):1075-82 [9743526] J Immunol. 1999 Feb 15;162(4):2251-8 [9973501] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-01-136267 ER - TY - JOUR T1 - Tumor vasculature-targeted delivery of tumor necrosis factor-alpha. AN - 66784051; 19090007 AB - Recently, considerable efforts have been directed toward antivascular therapy as a new modality to treat human cancers. However, targeting a therapeutic gene of interest to the tumor vasculature with minimal toxicity to other tissues remains the objective of antivascular gene therapy. Tumor necrosis factor-alpha (TNF-alpha) is a potent antivascular agent but has limited clinical utility because of significant systemic toxicity. At the maximum tolerated doses of systemic TNF-alpha, there is no meaningful antitumor activity. Hence, the objective of this study was to deliver TNF-alpha targeted to tumor vasculature by systemic delivery to examine its antitumor activity. A hybrid adeno-associated virus phage vector (AAVP) was used that targets tumor endothelium to express TNF-alpha (AAVP-TNF-alpha). The activity of AAVP-TNF-alpha was analyzed in various in vitro and in vivo settings using a human melanoma tumor model. In vitro, AAVP-TNF-alpha infection of human melanoma cells resulted in high levels of TNF-alpha expression. Systemic administration of targeted AAVP-TNF-alpha to melanoma xenografts in mice produced the specific delivery of virus to tumor vasculature. In contrast, the nontargeted vector did not target to tumor vasculature. Targeted AAVP delivery resulted in expression of TNF-alpha, induction of apoptosis in tumor vessels, and significant inhibition of tumor growth. No systemic toxicity to normal organs was observed. Targeted AAVP vectors can be used to deliver TNF-alpha specifically to tumor vasculature, potentially reducing its systemic toxicity. Because TNF-alpha is a promising antivascular agent that currently is limited by its toxicity, the current results suggest the potential for clinical translation of this strategy. JF - Cancer AU - Tandle, Anita AU - Hanna, Engy AU - Lorang, Dominique AU - Hajitou, Amin AU - Moya, Catherine A AU - Pasqualini, Renata AU - Arap, Wadih AU - Adem, Asha AU - Starker, Elizabeth AU - Hewitt, Stephen AU - Libutti, Steven K AD - Tumor Angiogenesis Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 128 EP - 139 VL - 115 IS - 1 SN - 0008-543X, 0008-543X KW - Tumor Necrosis Factor-alpha KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Melanoma, Experimental -- blood supply KW - Humans KW - Genetic Vectors KW - Transduction, Genetic KW - Gene Expression KW - Dependovirus -- genetics KW - Genetic Therapy -- methods KW - Mice, Nude KW - Mice KW - Cell Line, Tumor KW - Melanoma, Experimental -- therapy KW - Skin Neoplasms -- therapy KW - Skin Neoplasms -- blood supply KW - Melanoma -- therapy KW - Tumor Necrosis Factor-alpha -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Melanoma -- blood supply UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66784051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+disabilities+research+reviews&rft.atitle=Fetal+alcohol+spectrum+disorders%3A+when+science%2C+medicine%2C+public+policy%2C+and+laws+collide.&rft.au=Warren%2C+Kenneth+R%3BHewitt%2C+Brenda+G&rft.aulast=Warren&rft.aufirst=Kenneth&rft.date=2009-01-01&rft.volume=15&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Developmental+disabilities+research+reviews&rft.issn=1940-5529&rft_id=info:doi/10.1002%2Fddrr.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-10 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.24001 ER - TY - JOUR T1 - Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis. AN - 66781886; 19118017 AB - Transgenic mice that overexpress PKCalpha in the epidermis (K5-PKCalpha mice) exhibit acute CXCR2-mediated intraepidermal neutrophilic inflammation and a strong epidermal hyperplasia in response to application of 12-O-tetradecanoylphorbol-13-acetate (TPA). We now show that hyperplasia is independent of infiltrating neutrophils. Furthermore, when K5-PKCalpha mice were initiated with 7,12-dimethylbenz(a)anthracene (DMBA) and promoted with a low dose of TPA, 58% of K5-PKCalpha mice developed skin papillomas that progressed to carcinoma, whereas wild-type mice did not develop tumors. We confirmed that CXCR2 is expressed by keratinocytes and showed that transformation by oncogenic ras (a hallmark of DMBA initiation) or TPA exposure induced all CXCR2 ligands. Ras induction of CXCR2 ligands was mediated by autocrine activation of epidermal growth factor receptor and nuclear factor-kappaB, and potentiated by PKCalpha. Oncogenic ras also induced CXCR2 ligands in keratinocytes genetically ablated for CXCR2. However, ras transformed CXCR2 null keratinocytes formed only small skin tumors in orthotopic skin grafts to CXCR2 intact hosts, whereas transformed wild-type keratinocytes produced large tumors. In vitro, CXCR2 was essential for CXCR2 ligand-stimulated migration of ras-transformed keratinocytes and for ligand activation of the extracellular signal-regulated kinase (ERK) and Akt pathways. Both migration and activation of ERK and Akt were restored by CXCR2 reconstitution of CXCR2 null keratinocytes. Thus, activation of CXCR2 on ras-transformed keratinocytes has both promigratory and protumorigenic functions. The up-regulation of CXCR2 ligands after initiation by oncogenic ras and promotion with TPA in the mouse skin model provides a mechanism to stimulate migration by both autocrine and paracrine pathways and contribute to tumor development. JF - Cancer research AU - Cataisson, Christophe AU - Ohman, Rebecca AU - Patel, Gopal AU - Pearson, Andrea AU - Tsien, Margaret AU - Jay, Steve AU - Wright, Lisa AU - Hennings, Henry AU - Yuspa, Stuart H AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute/NIH, 37 Convent Drive, Bethesda, MD 20892-4264, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 319 EP - 328 VL - 69 IS - 1 KW - Ligands KW - 0 KW - Receptors, Interleukin-8B KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Protein Kinase C-alpha KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Neutrophils -- pathology KW - Enzyme Activation KW - HeLa Cells KW - Humans KW - Mice KW - Protein Kinase C-alpha -- metabolism KW - Hair Follicle -- enzymology KW - Protein Kinase C-alpha -- biosynthesis KW - Drug Eruptions -- pathology KW - Female KW - Male KW - Skin Neoplasms -- enzymology KW - Cell Transformation, Neoplastic -- pathology KW - Keratinocytes -- enzymology KW - Cell Transformation, Neoplastic -- metabolism KW - Skin Neoplasms -- pathology KW - Keratinocytes -- pathology KW - Keratinocytes -- metabolism KW - Skin Neoplasms -- metabolism KW - Receptors, Interleukin-8B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66781886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Inducible+cutaneous+inflammation+reveals+a+protumorigenic+role+for+keratinocyte+CXCR2+in+skin+carcinogenesis.&rft.au=Cataisson%2C+Christophe%3BOhman%2C+Rebecca%3BPatel%2C+Gopal%3BPearson%2C+Andrea%3BTsien%2C+Margaret%3BJay%2C+Steve%3BWright%2C+Lisa%3BHennings%2C+Henry%3BYuspa%2C+Stuart+H&rft.aulast=Cataisson&rft.aufirst=Christophe&rft.date=2009-01-01&rft.volume=69&rft.issue=1&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-2490 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-30 N1 - Date created - 2009-01-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1995 May 1;55(9):1883-93 [7728756] J Immunol. 2003 Sep 1;171(5):2703-13 [12928424] Cancer Res. 1997 Aug 1;57(15):3180-8 [9242447] Mol Carcinog. 1997 Sep;20(1):151-8 [9328446] J Biol Chem. 1998 Apr 24;273(17):10095-8 [9553055] J Dermatol Sci. 1998 May;17(1):1-7 [9651822] Genes Dev. 1999 Jun 1;13(11):1382-97 [10364156] Nat Med. 1999 Jul;5(7):828-31 [10395330] J Cell Sci. 1999 Oct;112 ( Pt 20):3497-506 [10504298] Oncol Rep. 1999 Nov-Dec;6(6):1405-10 [10523720] Cancer Res. 2004 Nov 1;64(21):7801-12 [15520186] Cancer Cell. 2004 Nov;6(5):447-58 [15542429] Semin Cancer Biol. 2005 Apr;15(2):75-83 [15652452] J Immunol. 2005 Feb 1;174(3):1686-92 [15661932] Adv Cancer Res. 2005;93:159-87 [15797447] J Immunol. 2005 Apr 15;174(8):5047-56 [15814736] Cancer Cell. 2005 May;7(5):411-23 [15894262] Cancer Immunol Immunother. 2006 Mar;55(3):237-45 [16047143] Nat Rev Cancer. 2006 Jan;6(1):24-37 [16397525] Eur J Cancer. 2006 Apr;42(6):735-44 [16527478] Cancer Res. 2006 Apr 15;66(8):4279-84 [16618752] Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12493-8 [16891410] J Clin Invest. 2006 Oct;116(10):2757-66 [16964312] J Biol Chem. 2006 Nov 24;281(47):35931-41 [16990258] J Cell Sci. 2007 Aug 15;120(Pt 16):2851-63 [17666434] Cancer Cell. 2008 Jan;13(1):23-35 [18167337] Neoplasia. 2008 Feb;10(2):131-9 [18283335] Nat Protoc. 2008;3(5):799-810 [18451788] J Biol Chem. 2008 Sep 26;283(39):26538-47 [18662984] J Exp Med. 2003 Sep 1;198(5):747-55 [12953094] J Immunol. 2004 Mar 1;172(5):2853-60 [14978086] Oncogene. 2004 Mar 11;23(10):1902-10 [14661063] J Cell Sci. 2004 Nov 1;117(Pt 23):5489-96 [15479720] Nature. 1986 Oct 30-Nov 5;323(6091):822-4 [2430189] J Cell Biol. 1989 Sep;109(3):1207-17 [2475508] Mol Carcinog. 1991;4(3):196-202 [2064725] Mol Carcinog. 1991;4(3):210-9 [2064727] Carcinogenesis. 1993 Nov;14(11):2353-8 [8242866] J Exp Med. 1995 Jan 1;181(1):435-40 [7807024] Cancer Res. 2000 Jan 15;60(2):226-9 [10667563] J Biol Chem. 2000 Mar 10;275(10):6868-75 [10702246] J Invest Dermatol. 2000 May;114(5):976-83 [10771480] Cancer Res. 2000 Jul 1;60(13):3328-32 [10910032] Oncogene. 2000 Jul 20;19(31):3477-86 [10918606] J Invest Dermatol. 2000 Aug;115(2):234-44 [10951241] Cytokine. 2001 Jun 7;14(5):253-63 [11444905] Int J Cancer. 2001 Sep 1;93(5):635-43 [11477572] Nature. 2003 Feb 6;421(6923):639-43 [12571598] Am J Pathol. 2003 Jul;163(1):303-12 [12819035] Science. 1995 Jul 14;269(5221):230-4 [7618084] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-2490 ER - TY - JOUR T1 - Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. AN - 66780051; 19061394 AB - An extract from Phyllanthus engleri was identified in a bioinformatic analysis of NCI 60-cell natural product extract screening data that selectively inhibited the growth of renal cancer cell lines. Bioassay-guided fractionation yielded two new guaiane sesquiterpenes, englerins A (1) and B (2). Englerin A showed 1000-fold selectivity against six of eight renal cancer cell lines with GI(50) values ranging from 1-87 nM. The structures of 1 and 2 and their relative stereochemistry were established by spectroscopic methods. JF - Organic letters AU - Ratnayake, Ranjala AU - Covell, David AU - Ransom, Tanya T AU - Gustafson, Kirk R AU - Beutler, John A AD - Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, NCIFrederick, Frederick, Maryland 21702, USA. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 57 EP - 60 VL - 11 IS - 1 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Plant Extracts KW - Sesquiterpenes, Guaiane KW - englerin A KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Drug Screening Assays, Antitumor KW - Stereoisomerism KW - Dose-Response Relationship, Drug KW - Humans KW - Reference Standards KW - Biological Assay KW - Plant Stems -- chemistry KW - Cell Line, Tumor KW - Molecular Conformation KW - Inhibitory Concentration 50 KW - Plant Bark -- chemistry KW - Magnetic Resonance Spectroscopy -- standards KW - Plant Extracts -- pharmacology KW - Kidney Neoplasms -- pathology KW - Antineoplastic Agents, Phytogenic -- isolation & purification KW - Sesquiterpenes, Guaiane -- isolation & purification KW - Antineoplastic Agents, Phytogenic -- chemistry KW - Phyllanthus -- chemistry KW - Plant Extracts -- isolation & purification KW - Antineoplastic Agents, Phytogenic -- pharmacology KW - Sesquiterpenes, Guaiane -- pharmacology KW - Plant Extracts -- chemistry KW - Sesquiterpenes, Guaiane -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66780051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=Englerin+A%2C+a+selective+inhibitor+of+renal+cancer+cell+growth%2C+from+Phyllanthus+engleri.&rft.au=Ratnayake%2C+Ranjala%3BCovell%2C+David%3BRansom%2C+Tanya+T%3BGustafson%2C+Kirk+R%3BBeutler%2C+John+A&rft.aulast=Ratnayake&rft.aufirst=Ranjala&rft.date=2009-01-01&rft.volume=11&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=1523-7052&rft_id=info:doi/10.1021%2Fol802339w LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-12-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Ethnopharmacol. 1991 Sep;34(2-3):97-133 [1795536] Am J Clin Pathol. 1966 Jan;45(1):46-50 [5904203] Steroids. 2000 Mar;65(3):138-42 [10699592] Phytochemistry. 2003 Aug;63(8):877-81 [12895533] J Nat Prod. 2003 Aug;66(8):1097-100 [12932132] J Pharm Pharmacol. 2006 Dec;58(12):1559-70 [17331318] J Antibiot (Tokyo). 1976 Feb;29(2):125-31 [945258] J Natl Cancer Inst. 1989 Jul 19;81(14):1088-92 [2738938] J Ethnopharmacol. 1990 Oct;30(3):233-64 [2259214] Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):667s-670s [17255291] Toxicol Sci. 1999 Jul;50(1):117-26 [10445760] Med Res Rev. 1998 Jul;18(4):225-58 [9664291] J Ethnopharmacol. 1995 Jan;45(1):1-18 [7739222] J Ethnopharmacol. 1992 Apr;36(2):103-12 [1608266] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ol802339w ER - TY - JOUR T1 - Structure-function study of the glucose-6-phosphate transporter, an eukaryotic antiporter deficient in glycogen storage disease type Ib. AN - 66755192; 19008136 AB - Glycogen storage disease type Ib is caused by deficiencies in the glucose-6-phosphate transporter (G6PT), a phosphate (P(i))-linked antiporter capable of homologous (P(i):P(i)) and heterologous (G6P:P(i)) exchanges similar to the bacterial hexose-6-phosphate transporter, UhpT. Protease protection and glycosylation scanning assays have suggested that G6PT is anchored to the endoplasmic reticulum by 10 transmembrane domains. However, recent homology modeling proposed that G6PT may contain 12 helices and that amino acids essential for the functions of UhpT also play important roles in G6PT. Site-directed mutagenesis and in vitro expression assays demonstrated that only one of the four residues critical for UhpT activity is essential in G6PT. Furthermore, glycosylation scanning and protease sensitivity assays showed that the 10-domain model of G6PT is more probable than the 12-domain UhpT-like model. JF - Molecular genetics and metabolism AU - Pan, Chi-Jiunn AU - Chen, Shih-Yin AU - Lee, Soojung AU - Chou, Janice Y AD - Section on Cellular Differentiation, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, NIH, 10 Center Drive, Bethesda, MD 20892-1830, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 32 EP - 37 VL - 96 IS - 1 KW - Monosaccharide Transport Proteins KW - 0 KW - Glucose-6-Phosphate KW - 56-73-5 KW - Index Medicus KW - Animals KW - Protein Structure, Secondary KW - COS Cells KW - Glucose-6-Phosphate -- metabolism KW - Humans KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Biological Transport KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Mutation KW - Structure-Activity Relationship KW - Monosaccharide Transport Proteins -- metabolism KW - Glycogen Storage Disease Type I -- metabolism KW - Monosaccharide Transport Proteins -- chemistry KW - Monosaccharide Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66755192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+genetics+and+metabolism&rft.atitle=Structure-function+study+of+the+glucose-6-phosphate+transporter%2C+an+eukaryotic+antiporter+deficient+in+glycogen+storage+disease+type+Ib.&rft.au=Pan%2C+Chi-Jiunn%3BChen%2C+Shih-Yin%3BLee%2C+Soojung%3BChou%2C+Janice+Y&rft.aulast=Pan&rft.aufirst=Chi-Jiunn&rft.date=2009-01-01&rft.volume=96&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Molecular+genetics+and+metabolism&rft.issn=1096-7206&rft_id=info:doi/10.1016%2Fj.ymgme.2008.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-21 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Chem Biol. 2007 Jun;3(6):313-20 [17510649] J Clin Invest. 2007 Mar;117(3):784-93 [17318259] J Biol Chem. 1999 May 14;274(20):13865-9 [10318794] J Biol Chem. 1999 Mar 5;274(10):6148-53 [10037698] J Membr Biol. 1998 Jul 15;164(2):187-95 [9662562] FEBS Lett. 1997 Dec 15;419(2-3):235-8 [9428641] J Virol. 1997 Mar;71(3):1842-9 [9032314] J Biol Chem. 1995 Sep 8;270(36):21098-102 [7673140] Microbiol Rev. 1990 Mar;54(1):1-17 [2181257] J Bacteriol. 1988 Aug;170(8):3421-6 [3042749] J Biol Chem. 1986 Jul 15;261(20):9083-6 [3522583] J Biol Chem. 1984 May 25;259(10):6142-6 [6373751] Annu Rev Biochem. 2000;69:69-93 [10966453] FEBS Lett. 2001 Aug 31;504(3):87-93 [11532438] Curr Mol Med. 2002 Mar;2(2):121-43 [11949931] Semin Cell Dev Biol. 2007 Dec;18(6):732-42 [17997334] Blood. 2008 Jun 15;111(12):5704-11 [18420828] FASEB J. 2008 Jul;22(7):2206-13 [18337460] Microbiol Mol Biol Rev. 1998 Mar;62(1):1-34 [9529885] J Biol Chem. 2002 Sep 6;277(36):32837-42 [12093795] Anal Biochem. 1973 Dec;56(2):502-14 [4128882] Biochemistry. 2004 Jul 27;43(29):9289-97 [15260472] J Biol Chem. 2004 Mar 26;279(13):12479-83 [14718531] Protein Sci. 2003 Dec;12(12):2748-56 [14627735] J Biol Chem. 2003 Nov 21;278(47):47098-103 [13129915] Science. 2003 Aug 1;301(5633):616-20 [12893936] Hum Mol Genet. 2002 Dec 1;11(25):3199-207 [12444104] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ymgme.2008.10.005 ER - TY - JOUR T1 - Use of hair colouring products and risk of multiple myeloma among US women. AN - 66751831; 18805876 AB - To evaluate the association between personal hair dye use and risk of multiple myeloma among women. A population-based case-control study of 175 cases of multiple myeloma and 679 controls. Cases and controls were interviewed regarding the type and colour of hair colouring product used, age at first use, age use stopped, duration, and the frequency of use per year. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using unconditional logistic regression to compare never users with four exposure groups: all users, ever semi-permanent dye users, ever permanent dye users and dark permanent dye users (most frequent use). No association was found between ever reporting hair colouring product use and myeloma risk among all users (OR 0.8; 95% CI 0.5 to 1.1), semi-permanent dye users (OR 0.7; 95% CI 0.4 to 1.2), permanent dye users (OR 0.8; 95% CI 0.5 to 1.1) or dark permanent dye users (OR 0.8; 95% CI 0.5 to 1.3). There were no significant associations among women who used hair dyes before 30 years of age, started use before 1980, had >or=240 lifetime applications, or had used dark permanent dye for 28 or more years. No evidence of an association between hair colouring product use and myeloma risk was found. However, given the conflicting body of literature on hair colouring product use and risk of multiple myeloma, this question should be further evaluated in larger studies or consortia, and in high risk groups. JF - Occupational and environmental medicine AU - Koutros, S AU - Baris, D AU - Bell, E AU - Zheng, T AU - Zhang, Y AU - Holford, T R AU - Leaderer, B P AU - Landgren, O AU - Zahm, S Hoar AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8122, Bethesda, MD 20852, USA. Koutross@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 68 EP - 70 VL - 66 IS - 1 KW - Hair Dyes KW - 0 KW - Index Medicus KW - Young Adult KW - Aged, 80 and over KW - Humans KW - Connecticut -- epidemiology KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Female KW - Risk Assessment KW - Multiple Myeloma -- chemically induced KW - Multiple Myeloma -- epidemiology KW - Hair Dyes -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66751831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Use+of+hair+colouring+products+and+risk+of+multiple+myeloma+among+US+women.&rft.au=Koutros%2C+S%3BBaris%2C+D%3BBell%2C+E%3BZheng%2C+T%3BZhang%2C+Y%3BHolford%2C+T+R%3BLeaderer%2C+B+P%3BLandgren%2C+O%3BZahm%2C+S+Hoar&rft.aulast=Koutros&rft.aufirst=S&rft.date=2009-01-01&rft.volume=66&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foem.2008.041053 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-02 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Public Health. 1994 Jul;84(7):1142-4 [8017540] J Natl Cancer Inst. 1994 Oct 5;86(19):1466-70 [8089866] Int J Cancer. 2005 Feb 10;113(4):629-31 [15389468] Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2342-7 [17132770] Arch Environ Occup Health. 2005 Sep-Oct;60(5):249-56 [17290845] Cancer Causes Control. 1999 Dec;10(6):617-25 [10616830] Chem Res Toxicol. 2003 Sep;16(9):1162-73 [12971805] Am J Epidemiol. 2004 Jan 15;159(2):148-54 [14718216] Am J Ind Med. 1982;3(2):169-71 [7137173] Am J Ind Med. 1984;6(2):97-102 [6465143] IARC Sci Publ. 1985;(65):53-6 [4086087] Am J Public Health. 1992 Jul;82(7):990-7 [1609918] Am J Public Health. 1992 Dec;82(12):1673-4 [1456346] J Natl Cancer Inst. 1994 Feb 2;86(3):210-5 [8283493] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/oem.2008.041053 ER - TY - JOUR T1 - When more is less: excess and deficiency of autophagy coexist in skeletal muscle in Pompe disease. AN - 66751231; 19001870 AB - The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, which results from a deficiency of the glycogen-degrading lysosomal hydrolase acid-alpha glucosidase (GAA). Skeletal and cardiac muscle are most severely affected by the progressive expansion of glycogen-filled lysosomes. In both humans and an animal model of the disease (GAA KO), skeletal muscle pathology also involves massive accumulation of autophagic vesicles and autophagic buildup in the core of myofibers, suggesting an induction of autophagy. Only when we suppressed autophagy in the skeletal muscle of the GAA KO mice did we realize that the excess of autophagy manifests as a functional deficiency. This failure of productive autophagy is responsible for the accumulation of potentially toxic aggregate-prone ubiquitinated proteins, which likely cause profound muscle damage in Pompe mice. Also, by generating muscle-specific autophagy-deficient wild-type mice, we were able to analyze the role of autophagy in healthy skeletal muscle. JF - Autophagy AU - Raben, Nina AU - Baum, Rebecca AU - Schreiner, Cynthia AU - Takikita, Shoichi AU - Mizushima, Noboru AU - Ralston, Evelyn AU - Plotz, Paul AD - Arthritis and Rheumatism Branch, NIAMS, NIH, Bethesda, MD 20892-1820, USA. rabenn@arb.niams.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 111 EP - 113 VL - 5 IS - 1 KW - alpha-Glucosidases KW - EC 3.2.1.20 KW - Index Medicus KW - Animals KW - Humans KW - alpha-Glucosidases -- metabolism KW - Organ Specificity KW - Mice KW - alpha-Glucosidases -- deficiency KW - Mice, Knockout KW - Muscle, Skeletal -- pathology KW - Muscle, Skeletal -- ultrastructure KW - Autophagy KW - Glycogen Storage Disease Type II -- enzymology KW - Muscle, Skeletal -- enzymology KW - Glycogen Storage Disease Type II -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66751231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autophagy&rft.atitle=When+more+is+less%3A+excess+and+deficiency+of+autophagy+coexist+in+skeletal+muscle+in+Pompe+disease.&rft.au=Raben%2C+Nina%3BBaum%2C+Rebecca%3BSchreiner%2C+Cynthia%3BTakikita%2C+Shoichi%3BMizushima%2C+Noboru%3BRalston%2C+Evelyn%3BPlotz%2C+Paul&rft.aulast=Raben&rft.aufirst=Nina&rft.date=2009-01-01&rft.volume=5&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Autophagy&rft.issn=1554-8635&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-12-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2000 Nov 1;19(21):5720-8 [11060023] Cell Struct Funct. 2002 Dec;27(6):421-9 [12576635] Dev Cell. 2004 Apr;6(4):463-77 [15068787] J Cell Biol. 1972 Jan;52(1):41-51 [4331300] Mol Ther. 2005 Jan;11(1):48-56 [15585405] J Cell Biol. 2005 May 9;169(3):425-34 [15866887] Ann Neurol. 2006 Apr;59(4):700-8 [16532490] Nature. 2006 Jun 15;441(7095):885-9 [16625204] Nature. 2006 Jun 15;441(7095):880-4 [16625205] Autophagy. 2005 Jul;1(2):84-91 [16874052] Pathol Res Pract. 2006;202(9):631-8 [16781826] Autophagy. 2006 Oct-Dec;2(4):318-20 [16874053] Mol Ther. 2006 Dec;14(6):831-9 [17008131] Curr Neurol Neurosci Rep. 2007 Jan;7(1):71-7 [17217857] Autophagy. 2007 Jul-Aug;3(4):323-8 [17387262] J Biol Chem. 2007 Aug 17;282(33):24131-45 [17580304] Autophagy. 2007 Nov-Dec;3(6):546-52 [17592248] Autophagy. 2007 Nov-Dec;3(6):542-5 [17611390] Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7 [17712358] Autophagy. 2008 Feb;4(2):151-75 [18188003] Nature. 2008 Feb 28;451(7182):1069-75 [18305538] Autophagy. 2008 Jul;4(5):727-30 [18437051] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. AN - 66749833; 18927208 AB - Tasidotin, an oncolytic drug in phase II clinical trials, is a peptide analog of the antimitotic depsipeptide dolastatin 15. In tasidotin, the carboxyl-terminal ester group of dolastatin 15 has been replaced by a carboxy-terminal tert-butyl amide. As expected from studies with cemadotin, [(3)H]tasidotin, with the radiolabel in the second proline residue, was hydrolyzed intracellularly, with formation of N,N-dimethylvalyl-valyl-N-methylvalyl-prolyl-proline (P5), a pentapeptide also present in dolastatin 15 and cemadotin. P5 was more active as an inhibitor of tubulin polymerization and less active as a cytotoxic agent than tasidotin, cemadotin, and dolastatin 15. [(3)H]P5 was not the end product of tasidotin metabolism. Large amounts of [(3)H]proline were formed in every cell line studied, with proline ultimately becoming the major radiolabeled product. The putative second product of the hydrolysis of P5, N,N-dimethylvalyl-valyl-N-methylvalyl-proline (P4), had little activity as either an antitubulin or cytotoxic agent. In seven suspension cell lines, the cytotoxicity of tasidotin correlated with total cell uptake of the compound and was probably affected negatively by the extent of degradation of P5 to proline and, presumably, P4. The intracellular enzyme prolyl oligopeptidase probably degrades tasidotin to P5. When CCRF-CEM human leukemia cells were treated with N-benzyloxycarbonylprolylprolinal (BCPP), an inhibitor of prolyl oligopeptidase, there was a 30-fold increase in the IC(50) of tasidotin and a marked increase in intracellular [(3)H]tasidotin. BCPP also caused a 4-fold increase in the IC(50) of P5, so the enzyme probably does not convert P5 to P4. Inhibiting degradation of P5 should have led to a decrease in the IC(50) obtained for P5 in the presence of BCPP. JF - Molecular pharmacology AU - Bai, Ruoli AU - Edler, Michael C AU - Bonate, Peter L AU - Copeland, Terry D AU - Pettit, George R AU - Ludueña, Richard F AU - Hamel, Ernest AD - Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 218 EP - 226 VL - 75 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Depsipeptides KW - Oligopeptides KW - tasidotin KW - 05G07285DK KW - dolastatin 15 KW - 123884-00-4 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Dose-Response Relationship, Drug KW - Humans KW - Cell Culture Techniques -- methods KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Time Factors KW - Female KW - Burkitt Lymphoma -- pathology KW - Burkitt Lymphoma -- drug therapy KW - Depsipeptides -- toxicity KW - Antineoplastic Agents -- toxicity KW - Oligopeptides -- metabolism KW - Depsipeptides -- metabolism KW - Oligopeptides -- pharmacology KW - Oligopeptides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66749833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Intracellular+activation+and+deactivation+of+tasidotin%2C+an+analog+of+dolastatin+15%3A+correlation+with+cytotoxicity.&rft.au=Bai%2C+Ruoli%3BEdler%2C+Michael+C%3BBonate%2C+Peter+L%3BCopeland%2C+Terry+D%3BPettit%2C+George+R%3BLudue%C3%B1a%2C+Richard+F%3BHamel%2C+Ernest&rft.aulast=Bai&rft.aufirst=Ruoli&rft.date=2009-01-01&rft.volume=75&rft.issue=1&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/10.1124%2Fmol.108.051110 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-26 N1 - Date created - 2008-12-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Oncol. 1998 Dec;9(12):1323-30 [9932163] Cancer Res. 2007 Apr 15;67(8):3767-76 [17440090] Cancer Chemother Pharmacol. 2000;46(4):319-28 [11052630] Cell Mol Life Sci. 2002 Feb;59(2):349-62 [11915948] Cell Biochem Biophys. 2003;38(1):1-22 [12663938] Curr Med Chem Anticancer Agents. 2002 Jan;2(1):19-53 [12678750] J Neurochem. 1983 Jul;41(1):69-75 [6345724] Biochemistry. 1984 Aug 28;23(18):4173-84 [6487596] Biochem Pharmacol. 1990 Jun 15;39(12):1941-9 [2353935] J Biol Chem. 1990 Oct 5;265(28):17141-9 [2211617] J Natl Cancer Inst. 1991 Nov 20;83(22):1672-7 [1749020] Biochem Pharmacol. 1992 Jun 23;43(12):2637-45 [1632820] Leukemia. 1992 Oct;6(10):1048-53 [1405759] J Natl Cancer Inst. 1993 Mar 17;85(6):483-8 [8445676] Cancer Res. 1995 Jul 15;55(14):3085-92 [7606731] Cancer Chemother Pharmacol. 1996;38(3):225-32 [8646796] Anticancer Drug Des. 1998 Jan;13(1):47-66 [9474242] Anticancer Res. 1998 Mar-Apr;18(2A):1021-6 [9615758] J Clin Oncol. 1998 Aug;16(8):2770-9 [9704730] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/mol.108.051110 ER - TY - JOUR T1 - The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. AN - 66749755; 18703080 AB - Previous studies have reported that noradrenergic antagonists alleviate some of the symptoms of opiate withdrawal and dependence. Clinical studies also have shown that modification of the noradrenergic system may help protect patients from relapse. The present study tested the hypothesis that a dysregulated noradrenergic system has motivational significance in heroin self-administration of dependent rats. Prazosin, an alpha1-adrenergic antagonist (0.5, 1.0, 1.5 and 2.0 mg/kg, i.p.), was administered to adult male Wistar rats with a history of limited (1 h/day; short access) or extended (12 h/day; long access) access to intravenous heroin self-administration. Prazosin dose-dependently reduced heroin self-administration in long-access rats but not short-access rats, with 2 mg/kg of systemic prazosin significantly decreasing 1 h and 2 h heroin intake. Prazosin also reversed some changes in meal pattern associated with extended heroin access, including the taking of smaller and briefer meals (at 3 h), while also increasing total food intake and slowing the eating rate within meals (both 3 h and 12 h). Thus, prazosin appears to stimulate food intake in extended access rats by restoring meals to the normal size and duration. The data suggest that the alpha1 adrenergic system may contribute to mechanisms that promote dependence in rats with extended access. JF - Pharmacology, biochemistry, and behavior AU - Greenwell, Thomas N AU - Walker, Brendan M AU - Cottone, Pietro AU - Zorrilla, Eric P AU - Koob, George F AD - Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA 92037, United States. greenwellt@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 295 EP - 302 VL - 91 IS - 3 SN - 0091-3057, 0091-3057 KW - Adrenergic alpha-1 Receptor Agonists KW - 0 KW - Adrenergic alpha-Antagonists KW - Narcotics KW - Heroin KW - 70D95007SX KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Rats KW - Eating -- drug effects KW - Conditioning, Operant -- drug effects KW - Animals KW - Self Administration KW - Reinforcement Schedule KW - Drinking -- drug effects KW - Dose-Response Relationship, Drug KW - Rats, Wistar KW - Narcotics -- administration & dosage KW - Male KW - Heroin -- administration & dosage KW - Substance Abuse, Intravenous KW - Heroin Dependence -- drug therapy KW - Prazosin -- pharmacology KW - Heroin Dependence -- psychology KW - Adrenergic alpha-Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66749755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=The+alpha1+adrenergic+receptor+antagonist+prazosin+reduces+heroin+self-administration+in+rats+with+extended+access+to+heroin+administration.&rft.au=Greenwell%2C+Thomas+N%3BWalker%2C+Brendan+M%3BCottone%2C+Pietro%3BZorrilla%2C+Eric+P%3BKoob%2C+George+F&rft.aulast=Greenwell&rft.aufirst=Thomas&rft.date=2009-01-01&rft.volume=91&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/10.1016%2Fj.pbb.2008.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-02 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 1991;103(3):407-14 [2057541] Pharmacol Biochem Behav. 1988 Jan;29(1):175-81 [3353423] Pharmacol Biochem Behav. 1992 May;42(1):97-100 [1356275] J Appl Toxicol. 1992 Oct;12(5):309-10 [1447474] Neuroscience. 1993 Nov;57(1):143-51 [8278048] Life Sci. 1994;54(8):PL113-8 [7509021] Trends Pharmacol Sci. 1996 Jul;17(7):245-55 [8756183] Psychopharmacology (Berl). 1996 Jun;125(4):355-60 [8826540] J Chem Neuroanat. 1997 Jul;13(2):115-39 [9285356] Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):281-4 [9164583] Neurosci Biobehav Rev. 1997 Jan;21(1):91-104 [8994212] Psychopharmacology (Berl). 1998 May;137(2):184-90 [9630005] Science. 1998 Oct 9;282(5387):298-300 [9765157] Physiol Behav. 1998 Aug;65(1):157-70 [9811378] Psychopharmacology (Berl). 1999 May;144(2):111-20 [10394991] Ann N Y Acad Sci. 1999 Jun 29;877:486-98 [10415666] Methods Inf Med. 2004;43(5):457-60 [15702200] Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1450-67 [15637168] Science. 2006 Feb 17;311(5763):1017-20 [16484499] BMC Biol. 2006;4:8 [16613600] Neuropsychopharmacology. 2006 Dec;31(12):2692-707 [16452993] J Pharmacol Exp Ther. 2007 Jan;320(1):180-93 [17050784] Eur Neuropsychopharmacol. 2008 Apr;18(4):303-11 [17920248] Psychol Bull. 1979 Mar;86(2):420-8 [18839484] J Clin Psychiatry. 2000 Feb;61(2):129-33 [10732660] J Neurosci. 1999 Oct 15;19(20):RC35 [10516337] Brain Res Brain Res Rev. 2000 Aug;33(1):13-33 [10967352] Nutrition. 2000 Oct;16(10):953-60 [11054601] Nat Neurosci. 2001 Sep;4(9):943-7 [11528427] J Neurosci. 2002 Apr 1;22(7):2873-84 [11923452] J Clin Psychiatry. 2002 Jul;63(7):565-8 [12143911] Pharmacol Biochem Behav. 2002 Nov;73(4):941-9 [12213541] Eur J Pharmacol. 2002 Nov 29;455(2-3):117-26 [12445577] Eur J Pharmacol. 2003 Jan 24;460(2-3):127-34 [12559372] Am J Psychiatry. 2003 Feb;160(2):371-3 [12562588] Life Sci. 2003 Jun 27;73(6):715-26 [12801593] Neurosci Lett. 2003 Aug 21;347(2):136-8 [12873745] Nature. 2000 Jan 27;403(6768):430-4 [10667795] Neuropsychopharmacology. 2000 Apr;22(4):413-21 [10700660] Psychopharmacology (Berl). 2003 Oct;170(1):42-50 [12783156] Neurosci Biobehav Rev. 2004 Jan;27(8):739-49 [15019424] Crit Care. 2004 Apr;8(2):130-6 [15025774] Pharmacol Biochem Behav. 1976 Feb;4(2):129-35 [944451] Drug Alcohol Depend. 1977 Mar;2(2):141-8 [192530] Lancet. 1978 Sep 16;2(8090):599-602 [80526] Nature. 1978 Nov 9;276(5684):186-8 [216919] Eur J Clin Pharmacol. 1979 Sep;16(3):177-81 [499317] Naunyn Schmiedebergs Arch Pharmacol. 1981 Nov;317(3):273-5 [6119624] J Clin Psychiatry. 1982 Jun;43(6 Pt 2):25-9 [6282817] JAMA. 1985 Jul 5;254(1):81-3 [4039767] Psychopharmacology (Berl). 1986;88(3):392-7 [3083461] Pharmacol Biochem Behav. 1987 Feb;26(2):265-9 [2883663] Trends Pharmacol Sci. 1992 May;13(5):177-84 [1604710] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.pbb.2008.07.012 ER - TY - JOUR T1 - Clinical and dosimetric predictors of acute toxicity after a 4-week hypofractionated external beam radiotherapy regimen for prostate cancer: results from a multicentric prospective trial. AN - 66748850; 18538488 AB - To investigate predictors for gastrointestinal (GI) and genitourinary (GU) acute toxicity after a short-course hypofractionated radiotherapy regimen for prostate cancer. Three institutions included 102 patients with T1-T3N0M0 prostate cancer in a Phase II study. Patients were treated with 56 Gy in 16 fractions over 4 weeks. Acute toxicity was scored weekly during treatment and 1 and 2 months after treatment using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria extended with additional symptoms and the International Prostate Symptom Index (IPSS). Correlation with a number of clinical and dosimetric parameters was assessed by univariate and multivariate analyses. No Grade 3 or 4 GI side effects were observed. Grades 1 and 2 rectal GI toxicity occurred in 36%, and 38%, respectively. Corresponding figures for Grades 1 and 2 GU toxicity were 42% and 39%, respectively. Grade 3 or higher GU toxicity was detected in 4% of patients. In multivariate analysis, percent rectal volumes higher than 8% receiving doses >/=53 Gy (V(53)) were statistically correlated to Grade 2 acute rectal reaction (p = 0.006). For GU morbidity, only the IPSS pretreatment score was independently associated (p = 0.0036) with an increase in GU acute effects. Acute GU and GI toxicity were comparable with other series. Our data show that increased incidence and intensity of acute toxicity is a transient effect related to shorter overall treatment time rather than a larger effect in biological equivalent dose with respect to a conventional fractionation regime. JF - International journal of radiation oncology, biology, physics AU - Arcangeli, Stefano AU - Strigari, Lidia AU - Soete, Guy AU - De Meerleer, Gert AU - Gomellini, Sara AU - Fonteyne, Valerie AU - Storme, Guy AU - Arcangeli, Giorgio AD - Departments of Radiotherapy, Regina Elena National Cancer Institute, Rome, Italy. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 39 EP - 45 VL - 73 IS - 1 KW - Index Medicus KW - Dose Fractionation KW - Aged, 80 and over KW - Risk Factors KW - Radiotherapy Dosage KW - Humans KW - Belgium KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Dose-Response Relationship, Radiation KW - Risk Assessment -- methods KW - Male KW - Italy KW - Gastrointestinal Diseases -- etiology KW - Gastrointestinal Diseases -- diagnosis KW - Prostatic Neoplasms -- complications KW - Radiation Injuries -- diagnosis KW - Prostatic Neoplasms -- radiotherapy KW - Radiotherapy, Conformal -- adverse effects KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66748850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Clinical+and+dosimetric+predictors+of+acute+toxicity+after+a+4-week+hypofractionated+external+beam+radiotherapy+regimen+for+prostate+cancer%3A+results+from+a+multicentric+prospective+trial.&rft.au=Arcangeli%2C+Stefano%3BStrigari%2C+Lidia%3BSoete%2C+Guy%3BDe+Meerleer%2C+Gert%3BGomellini%2C+Sara%3BFonteyne%2C+Valerie%3BStorme%2C+Guy%3BArcangeli%2C+Giorgio&rft.aulast=Arcangeli&rft.aufirst=Stefano&rft.date=2009-01-01&rft.volume=73&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=1879-355X&rft_id=info:doi/10.1016%2Fj.ijrobp.2008.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-30 N1 - Date created - 2008-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijrobp.2008.04.005 ER - TY - JOUR T1 - Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction. AN - 66748479; 19096789 AB - Irradiation damage to salivary glands is a common iatrogenic consequence of treatment for head and neck cancers. The subsequent lack of saliva production leads to many functional and quality-of-life problems for affected patients and there is no effective conventional therapy. To address this problem, we developed an in vivo gene therapy strategy involving viral vector-mediated transfer of the aquaporin-1 cDNA to irradiation-damaged glands and successfully tested it in two pre-clinical models (irradiated rats and miniature pigs), as well as demonstrated its safety in a large toxicology and biodistribution study. Thereafter, a clinical research protocol was developed that has received approval from all required authorities in the United States. Patients are currently being enrolled in this study. JF - Handbook of experimental pharmacology AU - Baum, Bruce J AU - Zheng, Changyu AU - Cotrim, Ana P AU - McCullagh, Linda AU - Goldsmith, Corinne M AU - Brahim, Jaime S AU - Atkinson, Jane C AU - Turner, R James AU - Liu, Shuying AU - Nikolov, Nikolay AU - Illei, Gabor G AD - Molecular Physiology and Therapeutics Branch and Clinical Research Core, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892, USA. bbaum@dir.nidcr.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 403 EP - 418 IS - 190 SN - 0171-2004, 0171-2004 KW - AQP1 protein, human KW - 0 KW - Aquaporin 1 KW - 146410-94-8 KW - Index Medicus KW - Animals KW - Humans KW - Genetic Vectors KW - Clinical Trials as Topic KW - Disease Models, Animal KW - Research Design KW - Cell Line KW - Radiotherapy -- adverse effects KW - Adenoviridae -- genetics KW - Radiation Injuries -- genetics KW - Aquaporin 1 -- biosynthesis KW - Gene Transfer Techniques -- adverse effects KW - Xerostomia -- metabolism KW - Xerostomia -- therapy KW - Radiation Injuries -- metabolism KW - Xerostomia -- etiology KW - Salivary Glands -- radiation effects KW - Xerostomia -- genetics KW - Aquaporin 1 -- genetics KW - Genetic Therapy -- adverse effects KW - Radiation Injuries -- therapy KW - Genetic Therapy -- methods KW - Salivary Glands -- metabolism KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66748479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Aquaporin-1+gene+transfer+to+correct+radiation-induced+salivary+hypofunction.&rft.au=Baum%2C+Bruce+J%3BZheng%2C+Changyu%3BCotrim%2C+Ana+P%3BMcCullagh%2C+Linda%3BGoldsmith%2C+Corinne+M%3BBrahim%2C+Jaime+S%3BAtkinson%2C+Jane+C%3BTurner%2C+R+James%3BLiu%2C+Shuying%3BNikolov%2C+Nikolay%3BIllei%2C+Gabor+G&rft.aulast=Baum&rft.aufirst=Bruce&rft.date=2009-01-01&rft.volume=&rft.issue=190&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-79885-9_20 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3268-73 [9096382] Hum Gene Ther. 1996 Jun 10;7(9):1085-93 [8773510] Arch Oral Biol. 1998 Apr;43(4):297-303 [9839705] Int J Radiat Oncol Biol Phys. 2005 Aug 1;62(5):1510-6 [16029813] Ann N Y Acad Sci. 1999 Jun 18;875:294-300 [10415576] Radiat Res. 1999 Feb;151(2):150-8 [9952299] Hum Gene Ther. 2006 Nov;17(11):1122-33 [17069536] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar;103 Suppl:S66.e1-19 [17379158] Mol Ther. 2005 Mar;11(3):444-51 [15727941] Cancer Gene Ther. 1999 Nov-Dec;6(6):505-13 [10608347] Hum Gene Ther. 2002 Jan 1;13(1):15-63 [11779412] Int Rev Cytol. 2002;213:93-146 [11837896] Oral Dis. 2002 Jul;8(4):183-91 [12206399] Arch Otolaryngol Head Neck Surg. 2003 Feb;129(2):247-50 [12578459] Crit Rev Oral Biol Med. 2003;14(3):199-212 [12799323] Mol Genet Metab. 2003 Sep-Oct;80(1-2):148-58 [14567964] J Gene Med. 2004 Jan;6(1):55-63 [14716677] Ann N Y Acad Sci. 1993 Sep 20;694:17-23 [8105741] Am J Physiol. 1994 Jun;266(6 Pt 1):G1146-55 [8023944] Biochem Biophys Res Commun. 1998 May 29;246(3):584-8 [9618254] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/978-3-540-79885-9_20 ER - TY - JOUR T1 - A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells. AN - 66748438; 18996183 AB - Organisms exposed to ionizing radiation are mainly damaged by free radicals, which are generated by the radiolysis of water contained in the cells. Recently a significant reduction of tissue injury from irradiation damage was demonstrated by using MnSOD-plasmid/liposome treatments in the protection of murine lung. In this study we show that a new active recombinant human MnSOD (rMnSOD), easily administered in vivo, not only exerts the same radioprotective effect on normal cells and organisms as any MnSOD, but it is also radiosensitizing for tumor cells. In addition, we show how healthy animals, exposed to lethal doses of ionizing radiation and daily injections with rMnSOD, were protected from radiodamage and were still alive 30 days after the irradiation, while animals treated with only PBS solution, in the absence of rMnSOD, died after 7-8 days from the radiotreatments. The molecular analysis of all irradiated tissues revealed that the antiapoptotic AVEN gene appeared activated only in the animals treated in the presence of rMnSOD. The data suggest that rMnSOD deserves to be considered as a pharmaceutical tool for making radiotherapy more selective on cancer cells and to prevent and/or cure the accidental damage derived from exposure to ionizing radiation. JF - Free radical biology & medicine AU - Borrelli, Antonella AU - Schiattarella, Antonella AU - Mancini, Roberto AU - Morrica, Brunello AU - Cerciello, Vincenzo AU - Mormile, Maria AU - d'Alesio, Valentina AU - Bottalico, Laura AU - Morelli, Francesco AU - D'Armiento, Maria AU - D'Armiento, Francesco Paolo AU - Mancini, Aldo AD - Department of Molecular Biology and Biotherapy, National Cancer Institute of Naples, Italy. Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 110 EP - 116 VL - 46 IS - 1 KW - AVEN protein, human KW - 0 KW - Adaptor Proteins, Signal Transducing KW - Apoptosis Regulatory Proteins KW - Free Radical Scavengers KW - Free Radicals KW - Membrane Proteins KW - Radiation-Sensitizing Agents KW - Recombinant Proteins KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - Free Radicals -- toxicity KW - Gene Expression -- drug effects KW - Neoplasms -- drug therapy KW - Animals KW - Radiation Injuries -- prevention & control KW - Humans KW - Apoptosis -- radiation effects KW - Cell Line, Tumor KW - Mice KW - Radiation Tolerance -- drug effects KW - Radiation-Sensitizing Agents -- therapeutic use KW - Neoplasms -- radiotherapy KW - Apoptosis -- drug effects KW - Lethal Dose 50 KW - Mice, Inbred C57BL KW - Female KW - Gene Expression -- radiation effects KW - Radiation, Ionizing KW - Fibroblasts -- drug effects KW - Recombinant Proteins -- pharmacology KW - Apoptosis Regulatory Proteins -- genetics KW - Superoxide Dismutase -- administration & dosage KW - Free Radical Scavengers -- administration & dosage KW - Adaptor Proteins, Signal Transducing -- biosynthesis KW - Apoptosis Regulatory Proteins -- radiation effects KW - Superoxide Dismutase -- pharmacology KW - Fibroblasts -- pathology KW - Apoptosis Regulatory Proteins -- metabolism KW - Membrane Proteins -- biosynthesis KW - Apoptosis Regulatory Proteins -- biosynthesis KW - Fibroblasts -- radiation effects KW - Free Radical Scavengers -- pharmacology KW - Recombinant Proteins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66748438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=A+recombinant+MnSOD+is+radioprotective+for+normal+cells+and+radiosensitizing+for+tumor+cells.&rft.au=Borrelli%2C+Antonella%3BSchiattarella%2C+Antonella%3BMancini%2C+Roberto%3BMorrica%2C+Brunello%3BCerciello%2C+Vincenzo%3BMormile%2C+Maria%3Bd%27Alesio%2C+Valentina%3BBottalico%2C+Laura%3BMorelli%2C+Francesco%3BD%27Armiento%2C+Maria%3BD%27Armiento%2C+Francesco+Paolo%3BMancini%2C+Aldo&rft.aulast=Borrelli&rft.aufirst=Antonella&rft.date=2009-01-01&rft.volume=46&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-02 N1 - Date created - 2008-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.10.030 ER - TY - JOUR T1 - Non-human primates: model animals for developmental psychopathology. AN - 66743386; 18800061 AB - Non-human primates have been used to model psychiatric disease for several decades. The success of this paradigm has issued from comparable cognitive skills, brain morphology, and social complexity in adult monkeys and humans. Recently, interest in biological psychiatry has focused on similar brain, social, and emotional developmental processes in monkeys. In part, this is related to evidence that early postnatal experiences in human development may have profound implications for subsequent mental health. Non-human primate studies of postnatal phenomenon have generally fallen into three basic categories: experiential manipulation (largely manipulations of rearing), pharmacological manipulation (eg drug-induced psychosis), and anatomical localization (defined by strategic surgical damage). Although these efforts have been very informative each of them has certain limitations. In this review we highlight general findings from the non-human primate postnatal developmental literature and their implications for primate models in psychiatry. We argue that primates are uniquely capable of uncovering interactions between genes, environmental challenges, and development resulting in altered risk for psychopathology. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Nelson, Eric E AU - Winslow, James T AD - Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 90 EP - 105 VL - 34 IS - 1 KW - Index Medicus KW - Genotype KW - Animals KW - Psychoses, Substance-Induced KW - Mental Disorders -- chemically induced KW - Humans KW - Mental Disorders -- etiology KW - Social Environment KW - Primates -- psychology KW - Primates -- genetics KW - Psychopathology -- methods KW - Disease Models, Animal KW - Primates -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66743386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Non-human+primates%3A+model+animals+for+developmental+psychopathology.&rft.au=Nelson%2C+Eric+E%3BWinslow%2C+James+T&rft.aulast=Nelson&rft.aufirst=Eric&rft.date=2009-01-01&rft.volume=34&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.150 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-09 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.150 ER - TY - JOUR T1 - Identification of a cis-acting element responsive to ultrasound in the 5'-flanking region of the human heme oxygenase-1 gene. AN - 66740865; 18829152 AB - We previously found that the heme oxygenase-1 gene (hmox-1) was the most upregulated gene among 9,182 genes in human lymphoma U937 cells exposed to a 1-MHz continuous ultrasound using the cDNA microarray technique. However, little is known about the molecular mechanisms of the induction of hmox-1 expression by ultrasound. We investigated the mechanism using human prostate cancer DU145 cells in which expression of hmox-1 increased with sonication in a time and an intensity-dependent manner. When N-acetyl-L-cysteine or glutathione-monoethyl ester, a potent antioxidant, was added to cell culture, hmox-1 upregulation was attenuated, suggesting that oxidative stress caused by sonication is involved in this process. To identify cis-acting elements required for the ultrasound-mediated induction, we carried out transient expression assays with plasmids carrying the luciferase gene under control of deletion mutants of the 5'-flanking region of hmox-1. The results revealed that the upregulations by sonication were observed with deletion mutants carrying the E1 or E2 enhancer of the 5'-flanking region, suggesting stress-responsive elements (StRE) were involved in the induction because either enhancer contains a number of the element. Indeed, site-directed mutations within StRE decreased the reactivity of deletion mutants to sonication. A transcription factor NF-E2-related Factor 2 that binds to StRE would therefore be activated by oxidative stress induced by sonication. JF - Ultrasound in medicine & biology AU - Kagiya, Go AU - Ogawa, Ryohei AU - Ito, Shinji AU - Fukuda, Shigekazu AU - Hatashita, Masanori AU - Tanaka, Yoshikazu AU - Yamamoto, Kazutaka AU - Kondo, Takashi AD - Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 155 EP - 164 VL - 35 IS - 1 KW - Antioxidants KW - 0 KW - DNA Primers KW - Luciferases KW - EC 1.13.12.- KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Index Medicus KW - Analysis of Variance KW - Humans KW - Cell Line, Tumor KW - Gene Deletion KW - Mutagenesis, Site-Directed KW - Transfection -- methods KW - Base Sequence KW - Antioxidants -- pharmacology KW - Oxidative Stress KW - Molecular Sequence Data KW - Response Elements KW - Luciferases -- genetics KW - Male KW - Ultrasonics KW - Enhancer Elements, Genetic KW - Heme Oxygenase-1 -- genetics KW - Gene Expression Regulation KW - 5' Flanking Region UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66740865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+medicine+%26+biology&rft.atitle=Identification+of+a+cis-acting+element+responsive+to+ultrasound+in+the+5%27-flanking+region+of+the+human+heme+oxygenase-1+gene.&rft.au=Kagiya%2C+Go%3BOgawa%2C+Ryohei%3BIto%2C+Shinji%3BFukuda%2C+Shigekazu%3BHatashita%2C+Masanori%3BTanaka%2C+Yoshikazu%3BYamamoto%2C+Kazutaka%3BKondo%2C+Takashi&rft.aulast=Kagiya&rft.aufirst=Go&rft.date=2009-01-01&rft.volume=35&rft.issue=1&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+medicine+%26+biology&rft.issn=1879-291X&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2008.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-05 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2008.07.012 ER - TY - JOUR T1 - The dynorphin/kappa opioid receptor system: a new target for the treatment of addiction and affective disorders? AN - 66740243; 19079072 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Shippenberg, Toni S AD - Integrative Neuroscience Section, NIH/NIDA Intramural Research Program, Baltimore, MD, USA. tshippen@intra.nida.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 247 VL - 34 IS - 1 KW - Receptors, Opioid, kappa KW - 0 KW - Dynorphins KW - 74913-18-1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Drug Delivery Systems KW - Animals KW - Humans KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Substance-Related Disorders -- drug therapy KW - Mood Disorders -- drug therapy KW - Receptors, Opioid, kappa -- physiology KW - Dynorphins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66740243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=The+dynorphin%2Fkappa+opioid+receptor+system%3A+a+new+target+for+the+treatment+of+addiction+and+affective+disorders%3F&rft.au=Shippenberg%2C+Toni+S&rft.aulast=Shippenberg&rft.aufirst=Toni&rft.date=2009-01-01&rft.volume=34&rft.issue=1&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.165 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-09 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.165 ER - TY - JOUR T1 - Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice. AN - 66737620; 18974089 AB - There has been considerable interest in the use of genetically modified mice for detecting potential environmental carcinogens. For this reason, the National Toxicology Program has been evaluating Tg.AC hemizygous and p53 haploinsufficient mice as models to detect potential carcinogens. It was reasoned that these mouse models might also prove more effective than standard rodent models in evaluating the numerous disinfection byproducts that are found in low concentrations in drinking water. Dichloroacetic acid (DCA) is one of the most frequently found disinfection byproducts and DCA has been consistently shown to cause hepatocellular tumors in rats and mice in standard rodent studies. Tg.AC hemizygous and p53 haploinsufficient mice were exposed in the drinking water to DCA for up to 41 weeks. In a second study Tg.AC mice were subjected to dermal DCA exposure for up to 39 weeks. Increased incidences and severity of cytoplasmic vacuolization of hepatocytes were seen in the p53 mice, but there was no evidence of carcinogenic activity at exposures of up to 2000 mg/l in the drinking water. Increased incidences and severity of cytoplasmic vacuolization of hepatocytes were seen in the drinking water study with Tg.AC mice and a modest non-dose-related increase in pulmonary adenomas was observed in males exposed to 1000 mg/l in the drinking water. Dermal exposure up to 500 mg/kg for 39 weeks resulted in increased dermal papillomas at the site of application in Tg.AC mice. No significant increase in papillomas under the same study conditions was seen in the 26-week study. For DCA under these study conditions, the p53 and Tg.AC mice appear less sensitive to hepatocarcinogenesis than standard rodent models. These results suggest caution for the use of Tg.AC and p53 mice to screen unknown chemicals in drinking water for potential carcinogenicity. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Kissling, Grace E AU - Malarkey, David E AU - Vallant, Molly K AU - Johnson, Jerry D AU - Hejtmancik, Milton R AU - Herbert, Ronald A AU - Boorman, Gary A AD - Environmental Diseases and Medicine Program, Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709, USA. kissling@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 19 EP - 26 VL - 107 IS - 1 KW - Water KW - 059QF0KO0R KW - Dichloroacetic Acid KW - 9LSH52S3LQ KW - Index Medicus KW - Animals KW - Water -- chemistry KW - Water Supply KW - Liver Neoplasms -- chemically induced KW - Adenocarcinoma, Bronchiolo-Alveolar -- epidemiology KW - Disease Models, Animal KW - Liver Neoplasms -- epidemiology KW - Mice KW - Mice, Transgenic KW - Papilloma -- epidemiology KW - Carcinoma, Hepatocellular -- epidemiology KW - Vacuoles -- drug effects KW - Adenocarcinoma, Bronchiolo-Alveolar -- chemically induced KW - Skin Neoplasms -- chemically induced KW - Skin Neoplasms -- epidemiology KW - Vacuoles -- metabolism KW - Papilloma -- chemically induced KW - Carcinoma, Hepatocellular -- chemically induced KW - Female KW - Male KW - Dichloroacetic Acid -- administration & dosage KW - Dichloroacetic Acid -- toxicity KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Carcinogenicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66737620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Evaluation+of+dichloroacetic+acid+for+carcinogenicity+in+genetically+modified+Tg.AC+hemizygous+and+p53+haploinsufficient+mice.&rft.au=Kissling%2C+Grace+E%3BMalarkey%2C+David+E%3BVallant%2C+Molly+K%3BJohnson%2C+Jerry+D%3BHejtmancik%2C+Milton+R%3BHerbert%2C+Ronald+A%3BBoorman%2C+Gary+A&rft.aulast=Kissling&rft.aufirst=Grace&rft.date=2009-01-01&rft.volume=107&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfn228 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-07 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Toxicol Environ Health A. 1999 Dec 24;58(8):485-507 [10632141] Carcinogenesis. 2001 Sep;22(9):1511-9 [11532874] Drug Metab Rev. 2000 May;32(2):169-86 [10774773] Toxicol Appl Pharmacol. 2002 Jul 1;182(1):55-65 [12127263] Environ Health Perspect. 2003 Jan;111(1):53-64 [12515679] Environ Health Perspect. 2003 Apr;111(4):444-54 [12676597] Toxicol Sci. 2004 Feb;77(2):188-94 [14657512] Toxicology. 2004 Jul 1;199(2-3):169-83 [15147791] J Natl Cancer Inst. 1979 Apr;62(4):957-74 [285297] Toxicol Appl Pharmacol. 1987 Sep 15;90(2):183-9 [3629594] Toxicology. 1990 Sep;63(3):341-59 [2219130] Fundam Appl Toxicol. 1991 Feb;16(2):337-47 [2055364] Environ Mol Mutagen. 1992;19 Suppl 21:2-141 [1541260] Fundam Appl Toxicol. 1992 Aug;19(2):159-68 [1516771] Environ Health Perspect. 1995 Oct;103(10):942-50 [8529591] Fundam Appl Toxicol. 1996 Jun;31(2):192-9 [8789785] Toxicology. 1996 Dec 18;114(3):207-21 [8980710] IARC Monogr Eval Carcinog Risks Hum. 1995;63:33-477 [9139128] Mol Carcinog. 1997 Sep;20(1):108-14 [9328441] Toxicol Pathol. 1998 Jul-Aug;26(4):461-73 [9715504] Toxicol Lett. 1999 May 20;106(1):9-21 [10378446] Environ Health Perspect. 1999 Feb;107 Suppl 1:207-17 [10229719] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Toxicol Sci. 2000 Feb;53(2):213-23 [10696769] Natl Toxicol Program Genet Modif Model Rep. 2007 Apr;(11):1-168 [18784768] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfn228 ER - TY - JOUR T1 - Compartmental analysis of plasma and liver n-3 essential fatty acids in alcohol-dependent men during withdrawal. AN - 66736892; 18723835 AB - The mechanism by which chronic ethanol consumption reduces concentrations of long chain polyunsaturated (LCP) fatty acids (FA) in tissues of humans was investigated in alcohol-dependent (AD) men during early withdrawal and to a well-matched control group by fitting the concentration-time curves of d(5)-labeled n-3 FA from plasma and liver, which originated from an oral dose of d(5)-linolenic acid (d(5)-18:3n-3) ethyl ester to a compartmental model. Blood sampled over 168 h and a liver specimen obtained 96 h after isotope administration were analyzed for d(5)-18:3n-3, d(5)-20:5n-3, d(5)-22:5n-3, and d(5)-22:6n-3. Plasma 20:5n-3 and 22:5n-3 were lower in AD subjects, compared with controls (20:5n-3: -50%, 22:5n-3: -34%). Increased amounts of d(5)-18:3n-3 were directed toward synthesis of d(5)-20:5n-3 in AD subjects (P < .05). However, this effect was offset by larger amounts of 20:5n-3 lost from plasma (control: 2.0 vs. AD: 4.2 mg d(-1)). In livers of AD subjects, more d(5)-18:3n-3 and d(5)-22:5n-3 were utilized for synthesis of d(5)-20:5n-3 (+200%) and d(5)-22:6n-3 (+210%), respectively, than was predicted from plasma kinetics. Although, the potential to utilize linolenic acid for synthesis of LCP FA was greater in AD subjects compared with controls, heightened disappearance rates of 20:5n-3 reduced overall plasma concentrations of several endogenous n-3 LCP FA. JF - Journal of lipid research AU - Pawlosky, Robert J AU - Hibbeln, Joseph R AU - Herion, David AU - Kleiner, David E AU - Salem, Norman AD - Laboratory of Metabolic Control, National Cancer Institute NIH, Bethesda, MD, USA. bpawl@niaaa.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 154 EP - 161 VL - 50 IS - 1 SN - 0022-2275, 0022-2275 KW - Fatty Acids, Essential KW - 0 KW - Fatty Acids, Omega-3 KW - alpha-Linolenic Acid KW - 0RBV727H71 KW - Index Medicus KW - alpha-Linolenic Acid -- metabolism KW - Mass Spectrometry KW - Substance Withdrawal Syndrome -- metabolism KW - Area Under Curve KW - Humans KW - Adult KW - Biopsy KW - Substance Withdrawal Syndrome -- blood KW - Time Factors KW - Models, Biological KW - Male KW - Hepatocytes -- metabolism KW - Liver -- pathology KW - Fatty Acids, Omega-3 -- metabolism KW - Fatty Acids, Essential -- blood KW - Liver -- metabolism KW - Alcoholism -- metabolism KW - Fatty Acids, Essential -- metabolism KW - Fatty Acids, Omega-3 -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66736892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Compartmental+analysis+of+plasma+and+liver+n-3+essential+fatty+acids+in+alcohol-dependent+men+during+withdrawal.&rft.au=Pawlosky%2C+Robert+J%3BHibbeln%2C+Joseph+R%3BHerion%2C+David%3BKleiner%2C+David+E%3BSalem%2C+Norman&rft.aulast=Pawlosky&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=50&rft.issue=1&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=00222275&rft_id=info:doi/10.1194%2Fjlr.M800322-JLR200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-02 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1999 Sep;104(6):805-13 [10491416] Alcohol Clin Exp Res. 1999 Feb;23(2):311-7 [10069561] Hepatology. 2005 Jun;41(6):1313-21 [15915461] Alcohol Clin Exp Res. 2001 Aug;25(8):1231-7 [11505055] J Lipid Res. 2001 Aug;42(8):1257-65 [11483627] J Lipid Res. 2007 Apr;48(4):935-43 [17234605] Alcohol Clin Exp Res. 2001 Dec;25(12):1758-65 [11781509] Br J Nutr. 2002 Oct;88(4):355-63 [12323085] Biol Psychiatry. 2003 Mar 1;53(5):431-41 [12614996] Br J Nutr. 2003 Nov;90(5):993-4; discussion 994-5 [14667193] Fed Proc. 1972 Sep-Oct;31(5):1451-7 [5056171] Biol Psychiatry. 1978 Oct;13(5):551-65 [728507] Lipids. 1980 Apr;15(4):263-8 [7374380] Alcohol Clin Exp Res. 1983 Spring;7(2):220-6 [6408939] Alcohol Clin Exp Res. 1983 Fall;7(4):424-30 [6419631] Ann Nutr Metab. 1985;29(4):246-52 [4026205] J Lipid Res. 1985 Jul;26(7):806-18 [4040952] Eur J Clin Nutr. 1988 Sep;42(9):797-803 [2846266] Biomed Chromatogr. 1990 Nov;4(6):234-8 [2289046] Alcohol Alcohol. 1991;26(4):459-64 [1760057] Free Radic Biol Med. 1992;12(3):219-40 [1563648] J Intern Med. 1992 Apr;231(4):349-56 [1588258] J Am Coll Nutr. 1992 Jun;11(3):304-8 [1619182] Arch Gen Psychiatry. 1992 Aug;49(8):630-6 [1637253] Hepatology. 1992 Aug;16(2):448-53 [1639354] Am J Clin Nutr. 1992 Sep;56(3):467-74 [1503056] J Lipid Res. 1992 Nov;33(11):1711-7 [1464754] Alcohol Alcohol. 1993 May;28(3):287-95 [8352840] Gastroenterology. 1994 Jan;106(1):152-9 [8276177] J Clin Invest. 1994 Jan;93(1):450-4 [8282819] Hepatology. 1994 May;19(5):1229-40 [8175146] Alcohol Alcohol. 1994 Sep;29(5):493-502 [7811333] N Engl J Med. 1995 May 4;332(18):1198-203 [7700313] Am J Clin Nutr. 1995 Jun;61(6):1284-9 [7762532] Hepatology. 1996 Apr;23(4):872-80 [8666344] Circulation. 1996 Jul 1;94(1):19-25 [8964113] Am J Epidemiol. 1996 Aug 15;144(4):325-34 [8712189] J Biol Chem. 1999 Jan 1;274(1):471-7 [9867867] Alcohol. 2004 Aug;34(1):27-33 [15670662] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1194/jlr.M800322-JLR200 ER - TY - JOUR T1 - Less is more, except when less is less: Studying joint effects. AN - 66734312; 18598750 AB - Most diseases are complex in that they are caused by the joint action of multiple factors, both genetic and environmental. Over the past few decades, the mathematical convenience of logistic regression has served to enshrine the multiplicative model, to the point where many epidemiologists believe that departure from additivity on a log scale implies that two factors interact in causing disease. Other terminology in epidemiology, where students are told that inequality of relative risks across levels of a second factor should be seen as "effect modification," reinforces an uncritical acceptance of multiplicative joint effect as the biologically meaningful no-interaction null. Our first task, when studying joint effects, is to understand the limitations of our definitions for "interaction," and recognize that what statisticians mean and what biologists might want to mean by interaction may not coincide. Joint effects are notoriously hard to identify and characterize, even when asking a simple and unsatisfying question, like whether two effects are log-additive. The rule of thumb for such efforts is that a factor-of-four sample size is needed, compared with that needed to demonstrate main effects of either genes or exposures. So strategies have been devised that focus on the most informative individuals, either through risk-based sampling for a cohort, or case-control sampling, extreme phenotype sampling, pooling, two-stage sampling, exposed-only, or case-only designs. These designs gain efficiency, but at a cost of flexibility in models for joint effects. A relatively new approach avoids population controls by genotyping case-parent triads. Because it requires parents, the method works best for diseases with onset early in life. With this design, the role of autosomal genetic variants is assessed by in effect treating the nontransmitted parental alleles as controls for affected offspring. Despite advantages for looking at genetic effects, the triad design faces limitations when examining joint effects of genetic and environmental factors. Because population-based controls are not included, main effects for exposures cannot be estimated, and consequently one only has access to inference related to a multiplicative null. We have proposed a hybrid approach that offers the best features of both case-parent and case-control designs. Through genotyping of parents of population-based controls and assuming Mendelian transmission, power is markedly enhanced. One can also estimate main effects for exposures and now flexibly assess models for joint effects. JF - Genomics AU - Weinberg, C R AD - National Institute of Environmental Health Sciences, MD A3-03, P.O. Box 12233, Research Triangle Park, NC 27709, USA. weinber2@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 10 EP - 12 VL - 93 IS - 1 KW - Index Medicus KW - Genotype KW - Epidemiologic Methods KW - Humans KW - Case-Control Studies KW - Parents KW - Research Design KW - Models, Genetic KW - Environmental Exposure KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66734312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Less+is+more%2C+except+when+less+is+less%3A+Studying+joint+effects.&rft.au=Weinberg%2C+C+R&rft.aulast=Weinberg&rft.aufirst=C&rft.date=2009-01-01&rft.volume=93&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=1089-8646&rft_id=info:doi/10.1016%2Fj.ygeno.2008.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biometrics. 1999 Sep;55(3):718-26 [11314998] Eur J Hum Genet. 2004 Nov;12(11):964-70 [15340361] Am J Epidemiol. 1982 Jan;115(1):119-28 [7055123] Am J Epidemiol. 1986 Jan;123(1):162-73 [3940436] Am J Hum Genet. 1993 Mar;52(3):506-16 [8447318] Stat Med. 1994 Jan 30;13(2):153-62 [8122051] Am J Hum Genet. 1998 Apr;62(4):969-78 [9529360] Am J Epidemiol. 1998 Nov 1;148(9):893-901 [9801020] Am J Hum Genet. 1999 Jul;65(1):229-35 [10364536] Am J Hum Genet. 2005 Oct;77(4):627-36 [16175508] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ygeno.2008.06.002 ER - TY - JOUR T1 - Age at menarche and weight concerns in relation to smoking trajectory and dependence among adolescent girls enrolled in a smoking cessation trial. AN - 66724378; 18940275 AB - Many girls adopt dieting and other practices (i.e. cigarette smoking) to control weight during puberty. This analysis explored the relationship between age at menarche and onset of daily smoking, and whether this relationship was influenced by weight concerns among treatment seeking female adolescents. The sample consisted of 71 participants enrolled in a smoking cessation trial (age 15.2+/-1.3 years; 74.7% European American, baseline BMI 24.7+/-5.4, age at menarche 11.7+/-1.3 years, Fagerström Test for Nicotine Dependence score 7.0+/-1.2). Over 60% of participants reported weight concerns at baseline, based on responses to the Eating Disorders module from the Diagnostic Interview for Children and Adolescents. Linear regression analyses revealed a significant association between age at menarche and age of onset of daily smoking (beta=0.18+/-0.09, p=0.038). Having weight concerns did not modify the relationships between age at menarche and smoking trajectory/severity or abstinence. Findings support previous research showing that early maturation represents a risk factor for substance use. Further study in larger samples that include non-treatment-seeking adolescent female smokers is warranted. JF - Addictive behaviors AU - Jaszyna-Gasior, Maria AU - Schroeder, Jennifer R AU - Thorner, Elissa D AU - Heishman, Stephen J AU - Collins, Charles C AU - Lo, Suzanne AU - Moolchan, Eric T AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Biomedical Research Center, Baltimore, Maryland 21224, USA. Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 92 EP - 95 VL - 34 IS - 1 KW - Nicotinic Agonists KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Nicotine -- therapeutic use KW - Nicotinic Agonists -- therapeutic use KW - Humans KW - Child KW - Adolescent KW - Female KW - Smoking Cessation -- psychology KW - Tobacco Use Disorder -- drug therapy KW - Body Weight -- drug effects KW - Menarche -- physiology KW - Feeding and Eating Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66724378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Age+at+menarche+and+weight+concerns+in+relation+to+smoking+trajectory+and+dependence+among+adolescent+girls+enrolled+in+a+smoking+cessation+trial.&rft.au=Jaszyna-Gasior%2C+Maria%3BSchroeder%2C+Jennifer+R%3BThorner%2C+Elissa+D%3BHeishman%2C+Stephen+J%3BCollins%2C+Charles+C%3BLo%2C+Suzanne%3BMoolchan%2C+Eric+T&rft.aulast=Jaszyna-Gasior&rft.aufirst=Maria&rft.date=2009-01-01&rft.volume=34&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=1873-6327&rft_id=info:doi/10.1016%2Fj.addbeh.2008.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-30 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.addbeh.2008.08.001 ER - TY - JOUR T1 - High-throughput protein expression using cell-free system. AN - 66717217; 18988029 AB - One of the main challenges in this post genomic era is the development and implementation of efficient methods of protein synthesis. A clear understanding of the role of genes in an organism is to comprehend the biological functions of all of its proteins. Acquiring this knowledge will depend in part on the success of rapid synthesis and purification of proteins. The future of structural genomics and functional proteomics depends on the availability of abundantly expressing, soluble proteins in a high-throughput manner. Conventional cell based methods of protein expression is rather laborious, time consuming and the ways to fail are numerous including solubility, toxicity to the host and instability (e.g. proteolysis). Cell-free or in vitro protein synthesis, on the other hand allows the expression and analysis of protein synthesis, may solve many of these problems. It is a simple open system which lends itself for manipulations and modifications to influence protein folding, disulfide bond formation, incorporation of unnatural amino acids, protein stability (by incorporating protease inhibitors in the system) and even the expression of toxic proteins. Cell-free synthesis can also be used as a reliable screening methodology for subsequent protein expression in vivo. Furthermore, this technology is readily amenable to automation. Here, we present a protocol for expressing recombinant proteins with high yield in a standard 96-well plate format using E. coli cell-free extract in a batch mode. JF - Methods in molecular biology (Clifton, N.J.) AU - Sitaraman, Kalavathy AU - Chatterjee, Deb K AD - Protein Expression Laboratory, SAIC-Frederick, Inc., National Cancer Institute at Frederick, MD, USA. Y1 - 2009 PY - 2009 DA - 2009 SP - 229 EP - 244 VL - 498 SN - 1064-3745, 1064-3745 KW - Buffers KW - 0 KW - Recombinant Proteins KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Ribosomes -- metabolism KW - Protein Biosynthesis KW - Animals KW - DNA -- genetics KW - Transcription, Genetic KW - Escherichia coli -- metabolism KW - Recombinant Proteins -- biosynthesis KW - Cell Fractionation -- methods KW - Ribosome Subunits, Small, Bacterial -- metabolism KW - Escherichia coli -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66717217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=High-throughput+protein+expression+using+cell-free+system.&rft.au=Sitaraman%2C+Kalavathy%3BChatterjee%2C+Deb+K&rft.aulast=Sitaraman&rft.aufirst=Kalavathy&rft.date=2009-01-01&rft.volume=498&rft.issue=&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-196-3_15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-59745-196-3_15 ER - TY - JOUR T1 - Effect of indoor air pollution from biomass fuel use on argyrophilic nuclear organizer regions in buccal epithelial cells. AN - 66635939; 19888913 AB - This study investigated the effect of indoor air pollution from biomass-fuel use on the expression of argyrophilic nucleolar organizer regions (AgNORs), an indicator of ribosome biosynthesis, in epithelial cells of oral mucosa. AgNORs were evaluated using cytochemical staining in 62 nonsmoking indian women (median age, 34 years), who cooked exclusively with biomass, and 55 age-matched women, who were from a similar neighborhood and cooked with relatively clean liquefied petroleum gas (LPG). Concentrations of particulate pollutants in indoor air were measured using a real-time aerosol monitor. Compared to the LPG-using controls, biomass-fuel users showed a remarkably increased number of AgNOR dots per nucleus (6.08 +/-2.26 vs 3.16 +/-0.86, p < 0.001), AgNOR size (0.85 +/-0.19 vs 0.53 +/-0.15 mum2, p < 0.001), and percentage of AgNOR-occupied nuclear area (4.88 +/-1.49 vs 1.75 +/-0.13%, p < 0.001). Biomass-using households had 2 to 4 times more particulate pollutants than that of LPG-using households. The changes in AgNOR expression were positively associated with PM10 and PM2.5 levels in indoor air after controlling for potential confounders such as age, kitchen location, and family income. Thus, biomass smoke appears to be a risk factor for abnormal cell growth via upregulation of ribosome biogenesis. JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer AU - Mondal, Nandan K AU - Dutta, Anindita AU - Banerjee, Anirban AU - Chakraborty, Sreeparna AU - Lahiri, Twisha AU - Ray, Manas Ranjan AD - Department of Experimental Hematology, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2009 PY - 2009 DA - 2009 SP - 253 EP - 259 VL - 28 IS - 3 KW - Air Pollutants KW - 0 KW - Antigens, Nuclear KW - Smoke KW - nucleolar organizer region associated proteins KW - Index Medicus KW - Humans KW - Cooking KW - Adult KW - Silver Staining KW - Energy-Generating Resources KW - Female KW - Smoke -- adverse effects KW - Air Pollution, Indoor -- adverse effects KW - Air Pollution, Indoor -- analysis KW - Mouth Mucosa -- pathology KW - Antigens, Nuclear -- drug effects KW - Biomass KW - Nucleolus Organizer Region -- drug effects KW - Air Pollutants -- adverse effects KW - Mouth Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66635939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.atitle=Effect+of+indoor+air+pollution+from+biomass+fuel+use+on+argyrophilic+nuclear+organizer+regions+in+buccal+epithelial+cells.&rft.au=Mondal%2C+Nandan+K%3BDutta%2C+Anindita%3BBanerjee%2C+Anirban%3BChakraborty%2C+Sreeparna%3BLahiri%2C+Twisha%3BRay%2C+Manas+Ranjan&rft.aulast=Mondal&rft.aufirst=Nandan&rft.date=2009-01-01&rft.volume=28&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.issn=2162-6537&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-11-17 N1 - Date created - 2009-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NATO-Russia: Is the "Russian Question" European? TT - OTAN-Russie: la "question russe" est-elle Europeenne? AN - 60558953; 201013443 AB - The Russia-NATO relationship has inherited a complicated set of mutual perceptions from the successive enlargements of the Alliance & the campaign in Kosovo. But it can no longer be thought of simply in terms of European security: Russia's renewed potential & ambitions have raised the issue to a higher level. The US/Europe/Russia triangle will play a role in global security from now on, & it is in this framework that the future of NATO-Russia relations should be understood. Adapted from the source document. JF - Politique etrangere AU - Gomart, Thomas AD - Centre Russie/NEI Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 845 EP - 858 PB - IFRI, Paris France IS - 4 SN - 0032-342X, 0032-342X KW - International Security KW - Kosovo KW - United States of America KW - Europe KW - International Relations KW - Russia KW - NATO KW - article KW - 9063: international relations; international relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60558953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Politique+etrangere&rft.atitle=NATO-Russia%3A+Is+the+%22Russian+Question%22+European%3F&rft.au=Gomart%2C+Thomas&rft.aulast=Gomart&rft.aufirst=Thomas&rft.date=2009-01-01&rft.volume=&rft.issue=4&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Politique+etrangere&rft.issn=0032342X&rft_id=info:doi/ LA - French DB - Worldwide Political Science Abstracts N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - NATO; Russia; International Relations; International Security; Europe; United States of America; Kosovo ER - TY - JOUR T1 - Natural Language Processing Versus Content-Based Image Analysis for Medical Document Retrieval AN - 57727688; 200903843 AB - One of the most significant recent advances in health information systems has been the shift from paper to electronic documents. While research on automatic text and image processing has taken separate paths, there is a growing need for joint efforts, particularly for electronic health records and biomedical literature databases. This work aims at comparing text-based versus image-based access to multimodal medical documents using state-of-the-art methods of processing text and image components. A collection of 180 medical documents containing an image accompanied by a short text describing it was divided into training and test sets. Content-based image analysis and natural language processing techniques are applied individually and combine for multimodal document analysis. The evaluation consists of an indexing task and a retrieval task based on the "gold standard" codes manually assigned to corpus documents. The performance of text-based and image-based access, as well as combined document features, is compared. Image analysis proves more adequate for both the indexing and retrieval of the images. In the indexing task, multimodal analysis outperforms both independent image and text analysis. This experiment shows that text describing images can be usefully analyzed in the framework of a hybrid text/image retrieval system. [Copyright 2009 Wiley Periodicals Inc.] JF - Journal of the American Society for Information Science and Technology AU - Neveol, Aurelie AU - Deserno, Thomas M AU - Darmoni, Stefan J AU - Guld, Mark Oliver AU - Aronson, Alan R AD - U.S. National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894 neveola@nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 123 EP - 134 PB - Wiley Subscription Services, Hoboken NJ VL - 60 IS - 1 SN - 1532-2882, 1532-2882 KW - Natural language processing KW - Text processing KW - Images KW - article KW - 13.14: INFORMATION STORAGE AND RETRIEVAL - SEARCHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57727688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.atitle=Natural+Language+Processing+Versus+Content-Based+Image+Analysis+for+Medical+Document+Retrieval&rft.au=Neveol%2C+Aurelie%3BDeserno%2C+Thomas+M%3BDarmoni%2C+Stefan+J%3BGuld%2C+Mark+Oliver%3BAronson%2C+Alan+R&rft.aulast=Neveol&rft.aufirst=Aurelie&rft.date=2009-01-01&rft.volume=60&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+for+Information+Science+and+Technology&rft.issn=15322882&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Natural language processing; Text processing; Images ER - TY - JOUR T1 - Mapping the Health Research Landscape in Sub-Saharan Africa: A Study of Trends in Biomedical Publications AN - 57708320; 200905040 AB - The process of research begins with grant-writing and concludes with publication. According to a recent study, in resource-poor settings, in-country national research and publications change clinical practice. One way to promote the visibility of these publications is for them to be peer reviewed and indexed in MEDLINE/PubMed. This process is fundamental not only to scientific progress, but to promoting the widespread communication of novel discoveries from low- and middle-income countries to the rest of the world. Worldwide scientific publishing activity over the past decade indicates that most countries in Sub-Saharan Africa (SSA) have low levels of publication. In a recent analysis, 31 of the world's 193 countries produce 97.5% of the world's most cited papers. South Africa, at number 29, is the only Sub-Saharan African country on this list, but little is known about the comparative volume of publications among the different countries in SSA. This study examined authorship in MEDLINE-indexed journal publications by Sub-Saharan African first authors as one metric of high-quality health research output. MEDLINE is the bibliographic database of the National Library of Medicine (NLM) at the US National Institutes of Health. Publication trends over a decade were tracked with two key objectives in mind: to approximate the research publishing landscape in the region, with special attention paid to country-specific (i.e., national) journals and to contrast the publication volume of the most productive country in SSA with publishing practices of other comparable countries outside the region. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Hofman, Karen J AU - Kanyengo, Christine W AU - Rapp, Barbara A AU - Kotzin, Sheldon AD - The John E. Fogarty International Center, National Institutes of Health, 16 Center Drive, MSC 6705, Bethesda, MD 20892-6705 hofmank@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 41 EP - 44 PB - Medical Library Association, Chicago, IL VL - 97 IS - 1 SN - 1536-5050, 1536-5050 KW - Bibliometrics KW - SubSaharan Africa KW - Scholarly publishing KW - Medicine KW - article KW - 16.16: PUBLISHING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57708320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Mapping+the+Health+Research+Landscape+in+Sub-Saharan+Africa%3A+A+Study+of+Trends+in+Biomedical+Publications&rft.au=Hofman%2C+Karen+J%3BKanyengo%2C+Christine+W%3BRapp%2C+Barbara+A%3BKotzin%2C+Sheldon&rft.aulast=Hofman&rft.aufirst=Karen&rft.date=2009-01-01&rft.volume=97&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2009-05-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Scholarly publishing; Bibliometrics; Medicine; SubSaharan Africa ER - TY - JOUR T1 - OBESITY AND BODY MASS INDEX (BMI) IN RELATION TO LIFE-STYLE AND PSYCHO-SOCIAL ASPECTS AN - 57314511; 200928517 AB - Obesity is increasing in middle-aged adults and the elderly. This multifactorial phenomenon may have different causes, such as incorrect nutritional and dietary habits, psycho-social aspects and sedentary life-style. It is becoming a serious problem, due also to the world's ageing society. The aim of this study is to provide preliminary results on BMI, life-style and psycho-social aspects in a sample of Italian subjects, which also assesses the relationship between obesity and psychological health. We hypothesize that obesity is related to many factors, such as life-style, behavioral, socio-economic, and psychological aspects. The sample was made up of 107 obese and non-obese subjects, aged 50-74. All participants were given a multidimensional assessment, which included anthropometric, psycho-social and life-style evaluation. As per the protocol a structured life-style questionnaire designed to gather information on anthropometric measurements, socio-economic factors, physical activity, smoking, alcohol and food intake. The Symptom Checklist-90 (SCL-90) for the evaluation of a broad range of psychological problems and symptoms of psychopathology; the Binge Eating Scale (BES) for the assessment of disorders in the eating habits were administered. BMI was associated with age and education, socio-economic status and smoking in both genders. Psychological factors for obesity differed between overweight men and women. In conclusion, obesity and non-obesity appear as two different entities in some aspects. The increase in the prevalence of obesity in elderly subjects could lead to disability and age-related diseases. For this reason, greater insight of the factors related to the development of obesity is required to develop treatment strategies weight-loss prevention programs. [Copyright Elsevier B.V.] JF - Archives of Gerontology and Geriatrics AU - Marcellini, F AU - Giuli, C AU - Papa, R AU - Tirabassi, G AU - Faloia, E AU - Boscaro, M AU - Polito, A AU - Ciarapica, D AU - Zaccaria, M AU - Mocchegiani, E AD - Center of Psycho-social Aspects of Aging, Scientific-Technological Area, INRCA (Italian National Institute on Aging), Via S. Margherita 5, 1-60124 Ancona, Italy f.marcellini@inrca.it Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 195 EP - 206 PB - Elsevier Ltd, The Netherlands VL - 49 SN - 0167-4943, 0167-4943 KW - Obesity Binge eating disorder Elderly Body mass index KW - Elderly people KW - Symptoms KW - Obesity KW - Socioeconomic factors KW - Body Mass Index KW - Psychological aspects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57314511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Gerontology+and+Geriatrics&rft.atitle=OBESITY+AND+BODY+MASS+INDEX+%28BMI%29+IN+RELATION+TO+LIFE-STYLE+AND+PSYCHO-SOCIAL+ASPECTS&rft.au=Marcellini%2C+F%3BGiuli%2C+C%3BPapa%2C+R%3BTirabassi%2C+G%3BFaloia%2C+E%3BBoscaro%2C+M%3BPolito%2C+A%3BCiarapica%2C+D%3BZaccaria%2C+M%3BMocchegiani%2C+E&rft.aulast=Marcellini&rft.aufirst=F&rft.date=2009-01-01&rft.volume=49&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Archives+of+Gerontology+and+Geriatrics&rft.issn=01674943&rft_id=info:doi/10.1016%2Fj.archger.2009.09.029 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-12-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Obesity; Body Mass Index; Psychological aspects; Symptoms; Elderly people; Socioeconomic factors DO - http://dx.doi.org/10.1016/j.archger.2009.09.029 ER - TY - JOUR T1 - Autism Spectrum Disorders and Childhood-Onset Schizophrenia: Clinical and Biological Contributions to a Relation Revisited AN - 57284482; 200904711 AB - Objective: To highlight emerging evidence for clinical and biological links between autism/pervasive developmental disorder (PDD) and schizophrenia, with particular attention to childhood-onset schizophrenia (COS). Method: Clinical, demographic, and brain developmental data from the National Institute of Mental Health (and other) COS studies and selected family, imaging, and genetic data from studies of autism, PDD, and schizophrenia were reviewed. Results: In the two large studies that have examined this systematically, COS is preceded by and comorbid with PDD in 30% to 50% of cases. Epidemiological and family studies find association between the disorders. Both disorders have evidence of accelerated trajectories of anatomic brain development at ages near disorder onset. A growing number of risk genes and/or rare small chromosomal variants (microdeletions or duplications) are shared by schizophrenia and autism. Conclusions: Biological risk does not closely follow DSM phenotypes, and core neurobiological processes are likely common for subsets of these two heterogeneous clinical groups. Long-term prospective follow-up of autistic populations and greater diagnostic distinction between schizophrenia spectrum and autism spectrum disorders in adult relatives are needed. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Rapoport, Judith AU - Chavez, Alex AU - Greenstein, Deanna AU - Addington, Anjene AU - Gogtay, Nitin AD - Child Psychiatry Branch, NIMH, Building 10, Room 3N202, 10 Center Drive, MSC 1600, Bethesda, MD 20892 Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 10 EP - 18 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 1 SN - 0890-8567, 0890-8567 KW - schizophrenia, childhood, autism, genetics, brain development KW - Schizophrenia KW - Brain KW - Phenotypes KW - Autism KW - Comorbidity KW - Autistic spectrum disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57284482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Autism+Spectrum+Disorders+and+Childhood-Onset+Schizophrenia%3A+Clinical+and+Biological+Contributions+to+a+Relation+Revisited&rft.au=Rapoport%2C+Judith%3BChavez%2C+Alex%3BGreenstein%2C+Deanna%3BAddington%2C+Anjene%3BGogtay%2C+Nitin&rft.aulast=Rapoport&rft.aufirst=Judith&rft.date=2009-01-01&rft.volume=48&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31818b1c63 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Autism; Autistic spectrum disorders; Brain; Phenotypes; Comorbidity DO - http://dx.doi.org/10.1097/CHI.0b013e31818b1c63 ER - TY - JOUR T1 - Are Patterns of Health Behavior Associated With Cancer Screening? AN - 57283881; 200906941 AB - Purpose. This study investigates the relationship between patterns of health behaviors and the use of cancer-screening tests while controlling for sociodemographic and health system factors. Design. Cross-sectional analysis of the 2000 National Health Interview (NHIS). Setting. Nationally representative sample. Subjects. Adults 50 years and older. Measures. Use of cancer-screening tests, health behaviors, sociodemographic factors, and health system factors from self-reported responses from the NHIS. Sixteen health behavior patterns were identified based on lifestyle recommendations for physical activity, tobacco use, alcohol consumption, and fruit and vegetable consumption. Results. Health behavior patterns, age, educational attainment, usual source of care, and health insurance were significantly associated with the use of breast, cervical, and colorectal cancer screening (p < .05). Approximate R2 for the four models ranged from .067 for colorectal cancer screening in women to .122 for cervical cancer screening. Having a usual source of care was the strongest correlate of screening; the magnitude of associations for health behavior patterns and demographic variables and screening was similar and much smaller than those for usual source of care. Conclusion. These findings demonstrate relationships between patterns of multiple health behaviors and use of recommended cancer-screening tests, even when accounting for factors known to influence test use. This suggests potential for addressing cancer screening in the context of multiple behavior change interventions once barriers to health care access are removed. Adapted from the source document. JF - American Journal of Health Promotion AU - Meissner, Helen I AU - Yabroff, K Robin AU - Dodd, Kevin W AU - Leader, Amy E AU - Ballard-Barbash, Rachel AU - Berrigan, David AD - Division of Cancer Control and Population Sciences. National Cancer Institute, Executive Plaza North, Suite 4102, 6130 Executive Blvd, MSC 7331, Bethesda, MD 20892-7331 Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 168 EP - 175 PB - AJHP Inc, West Bloomfield MI VL - 23 IS - 3 SN - 0890-1171, 0890-1171 KW - Health Behavior, Pattern, Cancer, Screening, Colon, Breast, Lifestyle, Prevention Research KW - Screening KW - Prevention KW - Health care KW - Colorectal cancer KW - Cancer KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57283881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Are+Patterns+of+Health+Behavior+Associated+With+Cancer+Screening%3F&rft.au=Meissner%2C+Helen+I%3BYabroff%2C+K+Robin%3BDodd%2C+Kevin+W%3BLeader%2C+Amy+E%3BBallard-Barbash%2C+Rachel%3BBerrigan%2C+David&rft.aulast=Meissner&rft.aufirst=Helen&rft.date=2009-01-01&rft.volume=23&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHPED N1 - SubjectsTermNotLitGenreText - Health behaviour; Screening; Prevention; Cancer; Colorectal cancer; Health care ER - TY - JOUR T1 - Repetitive TMS combined with exposure therapy for PTSD: A preliminary study AN - 57282110; 200907151 AB - Treatment for anxiety and post-traumatic stress disorder (PTSD) includes exposure therapy and medications, but some patients are refractory. Few studies of repetitive transcranial magnetic stimulation (rTMS) for anxiety or PTSD exist. In this preliminary report, rTMS was combined with exposure therapy for PTSD. Nine subjects with chronic, treatment-refractory PTSD were studied in a placebo-controlled, crossover design of imaginal exposure therapy with rTMS (1 Hz) versus sham. PTSD symptoms, serum and 24 h urine were obtained and analyzed. Effect sizes for PTSD symptoms were determined using Cohen's d. Active rTMS showed a larger effect size of improvement for hyperarousal symptoms compared to sham; 24-h urinary norepinephrine and serum T4 increased; serum prolactin decreased. Active rTMS with exposure may have symptomatic and physiological effects. Larger studies are needed to confirm these preliminary findings and verify whether rTMS plus exposure therapy has a role in the treatment of PTSD. [Copyright Elsevier B.V.] JF - Journal of Anxiety Disorders AU - Osuch, Elizabeth A AU - Benson, Brenda E AU - Luckenbaugh, David A AU - Geraci, Marilla AU - Post, Robert M AU - McCann, Una AD - Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MA, United States Elizabeth.osuch@lhsc.on.ca Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 54 EP - 59 PB - Elsevier Ltd, The Netherlands VL - 23 IS - 1 SN - 0887-6185, 0887-6185 KW - Post-traumatic stress disorder (PTSD) Transcranial magnetic stimulation (TMS) Psychological desensitization Psychological therapies Extinction KW - Transcranial magnetic stimulation KW - Posttraumatic stress disorder KW - Anxiety KW - Exposure therapy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57282110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Anxiety+Disorders&rft.atitle=Repetitive+TMS+combined+with+exposure+therapy+for+PTSD%3A+A+preliminary+study&rft.au=Osuch%2C+Elizabeth+A%3BBenson%2C+Brenda+E%3BLuckenbaugh%2C+David+A%3BGeraci%2C+Marilla%3BPost%2C+Robert+M%3BMcCann%2C+Una&rft.aulast=Osuch&rft.aufirst=Elizabeth&rft.date=2009-01-01&rft.volume=&rft.issue=190&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/10.1007%2F978-3-540-79885-9_20 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Exposure therapy; Transcranial magnetic stimulation; Anxiety DO - http://dx.doi.org/10.1016/j.janxdis.2008.03.015 ER - TY - JOUR T1 - Sex Differences in WISC-III Profiles of Children with High-functioning Pervasive Developmental Disorders AN - 57281634; 200909488 AB - Using the Japanese version of the Wechsler Intelligence Scale for Children-Third Edition (WISC-III), 26 girls with high-functioning (IQ >= 70) pervasive developmental disorders (HFPDD) (mean age, 8.2 years) were compared with 116 boys with HFPDD (mean age, 9.0 years). Compared with the boys, the girls scored significantly higher on the Processing Speed index, Coding, and Symbol Search, but scored significantly lower on Block Design. Although both groups showed weakness on Comprehension in the verbal domain, the girls' subtest profile in the performance domain was relatively even and significantly different from the boys', which was characterized by a peak on Block Design. Such differences should be replicated, and possible behavioral, neurological, and genetic links to these sex differences should be clarified. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Koyama, Tomonori AU - Kamio, Yoko AU - Inada, Naoko AU - Kurita, Hiroshi AD - Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8553, Japan Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 135 EP - 141 PB - Springer, Dordrecht The Netherlands VL - 39 IS - 1 SN - 0162-3257, 0162-3257 KW - Intelligence KW - High functioning KW - Developmentally disabled children KW - Intelligence tests KW - Pervasive developmental disorders KW - Gender differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Sex+Differences+in+WISC-III+Profiles+of+Children+with+High-functioning+Pervasive+Developmental+Disorders&rft.au=Koyama%2C+Tomonori%3BKamio%2C+Yoko%3BInada%2C+Naoko%3BKurita%2C+Hiroshi&rft.aulast=Koyama&rft.aufirst=Tomonori&rft.date=2009-01-01&rft.volume=39&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0610-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Gender differences; Developmentally disabled children; Pervasive developmental disorders; High functioning; Intelligence tests; Intelligence DO - http://dx.doi.org/10.1007/s10803-008-0610-6 ER - TY - JOUR T1 - Transitions In and Out of Alcohol Use Disorders: Their Associations with Conditional Changes in Quality of Life Over a 3-Year Follow-Up Interval AN - 57279038; 200905856 AB - Aims: The aim of this study was to investigate longitudinal changes in quality of life (QOL) as a function of transitions in alcohol use disorders (AUD) over a 3-year follow-up of a general US population sample. Methods: The analysis is based on individuals who drank alcohol in the year preceding the Wave 1 National Epidemiologic Survey on Alcohol and Related Conditions and were reinterviewed at Wave 2 (n = 22,245). Using multiple linear regression models, changes in SF-12 QOL were estimated as a function of DSM-IV AUD transitions, controlling for baseline QOL and multiple potential confounders. Results: Onset and offset of AUD were strongly associated with changes in mental/psychological functioning, with significant decreases in mental component summary (NBMCS) scores among individuals who developed dependence and significant increases among those who achieved full and partial remission from dependence. The increases in overall NBMCS and its social functioning, role emotional and mental health components were equally great for abstinent and nonabstinent remission from dependence, but improvements in bodily pain and general health were associated with nonabstinent remission only. Onset of abuse was unrelated to changes in QOL, and the increase in NBMCS associated with nonabstinent remission from abuse only was slight. Individuals with abuse only or no AUD who stopped drinking had significant declines in QOL. Conclusions: These results suggest the possible importance of preventing and treating AUD for maintaining and/or improving QOL. They are also consistent with the sick quitter hypothesis and suggest that abuse is less a mental disorder than a maladaptive pattern of behavior. Adapted from the source document. JF - Alcohol and Alcoholism AU - Dawson, Deborah A AU - Li, Ting-Kai AU - Chou, S Patricia AU - Grant, Bridget F AD - NIAAA/LEB, 5635 Fishers Lane, Room 3071, MSC 9304, Bethesda, MD 20892-9304, USA Tel: +1-301-435-2244, Fax: +1-301-443-1400 ddawson@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 84 EP - 92 PB - Oxford University Press, UK VL - 44 IS - 1 SN - 0735-0414, 0735-0414 KW - Social functioning KW - Psychiatric disorders KW - Mental health KW - Remission KW - Alcohol related disorders KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57279038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+Alcoholism&rft.atitle=Transitions+In+and+Out+of+Alcohol+Use+Disorders%3A+Their+Associations+with+Conditional+Changes+in+Quality+of+Life+Over+a+3-Year+Follow-Up+Interval&rft.au=Dawson%2C+Deborah+A%3BLi%2C+Ting-Kai%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2009-01-01&rft.volume=44&rft.issue=1&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+Alcoholism&rft.issn=07350414&rft_id=info:doi/10.1093%2Falcalc%2Fagn094 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - ALALDD N1 - SubjectsTermNotLitGenreText - Remission; Quality of life; Alcohol related disorders; Social functioning; Psychiatric disorders; Mental health DO - http://dx.doi.org/10.1093/alcalc/agn094 ER - TY - JOUR T1 - Predictors of outcome for short-term medically supervised opioid withdrawal during a randomized, multicenter trial of buprenorphine-naloxone and clonidine in the NIDA clinical trials network drug and alcohol dependence AN - 57276955; 200907998 AB - Few studies in community settings have evaluated predictors, mediators, and moderators of treatment success for medically supervised opioid withdrawal treatment. This report presents new findings about these factors from a study of 344 opioid-dependent men and women prospectively randomized to either buprenorphine-naloxone or clonidine in an open-label 13-day medically supervised withdrawal study. Subjects were either inpatient or outpatient in community treatment settings; however not randomized by treatment setting. Medication type (buprenorphine-naloxone versus clonidine) was the single best predictor of treatment retention and treatment success, regardless of treatment setting. Compared to the outpatient setting, the inpatient setting was associated with higher abstinence rates but similar retention rates when adjusting for medication type. Early opioid withdrawal severity mediated the relationship between medication type and treatment outcome with buprenorphine-naloxone being superior to clonidine at relieving early withdrawal symptoms. Inpatient subjects on clonidine with lower withdrawal scores at baseline did better than those with higher withdrawal scores; inpatient subjects receiving buprenorphine-naloxone did better with higher withdrawal scores at baseline than those with lower withdrawal scores. No relationship was found between treatment outcome and age, gender, race, education, employment, marital status, legal problems, baseline depression, or length/severity of drug use. Tobacco use was associated with worse opioid treatment outcomes. Severe baseline anxiety symptoms doubled treatment success. Medication type (buprenorphine-naloxone) was the most important predictor of positive outcome; however the paper also considers other clinical and policy implications of other results, including that inpatient setting predicted better outcomes and moderated medication outcomes. [Copyright 2008 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ziedonis, Douglas M AU - Amass, Leslie AU - Steinberg, Marc AU - Woody, George AU - Krejciiii, Jonathan AU - Annon, Jeffrey J AU - Cohen, Allan J AU - Waite-O'Brien, Nancy AU - Stine, Susan M AU - McCarty, Dennis AU - Reid, Malcolm S AU - Brown, Lawrence S, Jr AU - Maslansky, Robert AU - Winhusen, Theresa AU - Babcock, Dean AU - Brigham, Greg AU - Muir, Joan AU - Orr, Deborah AU - Buchan, Betty J AU - Horton, Terry AU - Ling, Walter AD - National Institute on Drug Abuse Clinical Trials Network (CTN), University of Massachusetts Medical School, New England Node, Worcester, MA 01581, USA Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 28 EP - 36 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 99 IS - 1-3 SN - 0376-8716, 0376-8716 KW - Buprenorphine Outcome predictors Heroin dependence Detoxification Opiate withdrawal Clinical trial KW - Withdrawal KW - Clonidine KW - Opioids KW - Analgesics KW - Treatment methods KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Predictors+of+outcome+for+short-term+medically+supervised+opioid+withdrawal+during+a+randomized%2C+multicenter+trial+of+buprenorphine-naloxone+and+clonidine+in+the+NIDA+clinical+trials+network+drug+and+alcohol+dependence&rft.au=Ziedonis%2C+Douglas+M%3BAmass%2C+Leslie%3BSteinberg%2C+Marc%3BWoody%2C+George%3BKrejciiii%2C+Jonathan%3BAnnon%2C+Jeffrey+J%3BCohen%2C+Allan+J%3BWaite-O%27Brien%2C+Nancy%3BStine%2C+Susan+M%3BMcCarty%2C+Dennis%3BReid%2C+Malcolm+S%3BBrown%2C+Lawrence+S%2C+Jr%3BMaslansky%2C+Robert%3BWinhusen%2C+Theresa%3BBabcock%2C+Dean%3BBrigham%2C+Greg%3BMuir%2C+Joan%3BOrr%2C+Deborah%3BBuchan%2C+Betty+J%3BHorton%2C+Terry%3BLing%2C+Walter&rft.aulast=Ziedonis&rft.aufirst=Douglas&rft.date=2009-01-01&rft.volume=99&rft.issue=1-3&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2008.06.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-04-08 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Analgesics; Clonidine; Opioids; Withdrawal; Treatment methods DO - http://dx.doi.org/10.1016/j.drugalcdep.2008.06.016 ER - TY - JOUR T1 - Prevalence of Enuresis and Its Association With Attention-Deficit/Hyperactivity Disorder Among U.S. Children: Results From a Nationally Representative Study AN - 57276756; 200904887 AB - Objective: There are no published nationally representative prevalence estimates of enuresis among children in the United States using standardized diagnostic criteria. This study sets out to describe the prevalence, demographic correlates, comorbidities, and service patterns for enuresis in a representative sample of U.S. children. Method: The diagnosis of enuresis was derived from parent-reported data for "enuresis, nocturnal" collected using the computerized version of the Diagnostic Interview Schedule for Children (C-DISC 4.0) from a nationally representative sample of 8- to 11-year-old children (n = 1, 136) who participated in the 2001-2004 National Health and Nutrition Examination Surveys. Results: The overall 12-month prevalence of enuresis was 4.45%. The prevalence in boys (6.21%) was significantly greater than that in girls (2.51 %). Enuresis was more common at younger ages and among black youth. Attention-deficit/ hyperactivity disorder (ADHD) was strongly associated with enuresis (odds ratio 2.88; 95% confidence interval 1.26-6.57). Only 36% of the enuretic children had received health services for enuresis. Conclusions: Enuresis is a common condition among children in the United States. Few families seek treatment for enuresis despite the potential for adverse effects on emotional health. Child health care professionals should routinely screen for enuresis and its effects on the emotional health of the child and the family. Assessment of ADHD should routinely include evaluation for enuresis and vice versa. Research on the explanations for the association between enuresis and ADHD is indicated. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Shreeram, Srirangam AU - He, Jian-Ping AU - Kalaydjian, Amanda AU - Brothers, Shannon AU - Merikangas, Kathleen Ries AD - Genetic Epidemiology, Branch, National Institute of Mental Health, 35 Convent Drive, 1A-202, MSC 3720, Bethesda, MD 20892-3720 s.shreeram@dc.gov Y1 - 2009/01// PY - 2009 DA - January 2009 SP - 35 EP - 41 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 48 IS - 1 SN - 0890-8567, 0890-8567 KW - enuresis, prevalence, health care use, comorbidities, ADHD KW - Enuresis KW - Attention deficit hyperactivity disorder KW - Children KW - Side effects KW - Hyperactivity KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Prevalence+of+Enuresis+and+Its+Association+With+Attention-Deficit%2FHyperactivity+Disorder+Among+U.S.+Children%3A+Results+From+a+Nationally+Representative+Study&rft.au=Shreeram%2C+Srirangam%3BHe%2C+Jian-Ping%3BKalaydjian%2C+Amanda%3BBrothers%2C+Shannon%3BMerikangas%2C+Kathleen+Ries&rft.aulast=Shreeram&rft.aufirst=Srirangam&rft.date=2009-01-01&rft.volume=48&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e318190045c LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Enuresis; Children; Prevalence; Attention deficit hyperactivity disorder; Hyperactivity; Side effects DO - http://dx.doi.org/10.1097/CHI.0b013e318190045c ER - TY - JOUR T1 - Testing in semiparametric models with interaction, with applications to gene-environment interactions AN - 37057000; 3822521 AB - Motivated from the problem of testing for genetic effects on complex traits in the presence of gene-environment interaction, we develop score tests in general semiparametric regression problems that involves Tukey style 1 degree-of-freedom form of interaction between parametrically and non-parametrically modelled covariates. We find that the score test in this type model, as recently developed by Chatterjee and co-workers in the fully parametric setting, is biased and requires undersmoothing to be valid in the presence of non-parametric components. Moreover, in the presence of repeated outcomes, the asymptotic distribution of the score test depends on the estimation of functions which are defined as solutions of integral equations, making implementation difficult and computationally taxing. We develop profiled score statistics which are unbiased and asymptotically efficient and can be performed by using standard bandwidth selection methods. In addition, to overcome the difficulty of solving functional equations, we give easy interpretations of the target functions, which in turn allow us to develop estimation procedures that can be easily implemented by using standard computational methods. We present simulation studies to evaluate type I error and power of the method proposed compared with a naive test that does not consider interaction. Finally, we illustrate our methodology by analysing data from a case-control study of colorectal adenoma that was designed to investigate the association between colorectal adenoma and the candidate gene NAT2 in relation to smoking history. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Maity, A AU - Carroll, R J AU - Mammen, E AU - Chatterjee, N AD - Texas A&M University ; Universität Mannheim ; National Cancer Institute Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 75 EP - 96 VL - 71 IS - 1 SN - 1369-7412, 1369-7412 KW - Sociology KW - Semiparametric models KW - Evaluation KW - Measurement KW - Genes KW - Quantitative analysis KW - Regression analysis KW - Linear models KW - Estimation KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37057000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Testing+in+semiparametric+models+with+interaction%2C+with+applications+to+gene-environment+interactions&rft.au=Maity%2C+A%3BCarroll%2C+R+J%3BMammen%2C+E%3BChatterjee%2C+N&rft.aulast=Maity&rft.aufirst=A&rft.date=2009-01-01&rft.volume=71&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5455 1678; 4403 7854; 10739 12228 10919; 7419 8163; 7854; 10530 3279 971 3286; 4551; 12228 10919 ER - TY - JOUR T1 - BacA, an ABC Transporter Involved in Maintenance of Chronic Murine Infections with Mycobacterium tuberculosis AN - 21504597; 12493391 AB - BacA is an inner membrane protein associated with maintenance of chronic infections in several diverse host-pathogen interactions. To understand the function of the bacA gene in Mycobacterium tuberculosis (Rv1819c), we insertionally inactivated this gene and analyzed the resulting mutant for a variety of phenotypes. BacA deficiency in M. tuberculosis did not affect sensitivity to detergents, acidic pH, and zinc, indicating that there was no global compromise in membrane integrity, and a comprehensive evaluation of the major lipid constituents of the cell envelope failed to reveal any significant differences. Infection of mice with this mutant revealed no impact on establishment of infection but a profound effect on maintenance of extended chronic infection and ultimate outcome. As in alphaproteobacteria, deletion of BacA in M. tuberculosis led to increased bleomycin resistance, and heterologous expression of the M. tuberculosis BacA homolog in Escherichia coli conferred sensitivity to antimicrobial peptides. These results suggest a striking conservation of function for BacA-related proteins in transport of a critical molecule that determines the outcome of the host-pathogen interaction. JF - Journal of Bacteriology AU - Domenech, Pilar AU - Kobayashi, Hajime AU - LeVier, Kristin AU - Walker, Graham C AU - Barry III, Clifton E AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Disease, National Institute of Allergy and Infectious Disease, 33 North Drive, Bethesda, Maryland 20892, cbarry@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 477 EP - 485 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 2 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Protein transport KW - ABC transporter KW - Detergents KW - Cell envelopes KW - Lipids KW - Membrane proteins KW - Bleomycin KW - Inner membranes KW - Host-pathogen interactions KW - Zinc KW - Chronic infection KW - Escherichia coli KW - Conservation KW - Tuberculosis KW - pH effects KW - Antimicrobial peptides KW - Mycobacterium tuberculosis KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21504597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=BacA%2C+an+ABC+Transporter+Involved+in+Maintenance+of+Chronic+Murine+Infections+with+Mycobacterium+tuberculosis&rft.au=Domenech%2C+Pilar%3BKobayashi%2C+Hajime%3BLeVier%2C+Kristin%3BWalker%2C+Graham+C%3BBarry+III%2C+Clifton+E&rft.aulast=Domenech&rft.aufirst=Pilar&rft.date=2009-01-01&rft.volume=191&rft.issue=2&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01132-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Protein transport; Detergents; ABC transporter; Lipids; Cell envelopes; Membrane proteins; Bleomycin; Host-pathogen interactions; Inner membranes; Chronic infection; Zinc; Conservation; Tuberculosis; Antimicrobial peptides; pH effects; Escherichia coli; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/JB.01132-08 ER - TY - JOUR T1 - The Crp-Activated Small Noncoding Regulatory RNA CyaR (RyeE) Links Nutritional Status to Group Behavior , AN - 21501153; 12493392 AB - Small noncoding regulatory RNAs (sRNAs) play a key role in regulating the expression of many genes in Escherichia coli and other bacteria. Many of the sRNAs identified in E. coli bind to mRNAs in an Hfq-dependent manner and stimulate or inhibit translation of the mRNAs. Several sRNAs are regulated by well-studied global regulators. Here, we report characterization of the CyaR (RyeE) sRNA, which was previously identified in a global search for sRNAs in E. coli. We demonstrated that CyaR is positively regulated by the global regulator Crp under conditions in which cyclic AMP levels are high. We showed by using microarray analysis and Northern blotting that several genes are negatively regulated by CyaR, including ompX, encoding a major outer membrane protein; luxS, encoding the autoinducer-2 synthase; nadE, encoding an essential NAD synthetase; and yqaE, encoding a predicted membrane protein with an unknown function. Using translational lacZ fusions to yqaE, ompX, nadE, and luxS, we demonstrated that the negative regulation of these genes by CyaR occurs at the posttranscriptional level and is direct. Different portions of a highly conserved 3' region of CyaR are predicted to pair with sequences near the ribosome binding site of each of these targets; mutations in this sequence affected regulation, and compensatory mutations in the target mRNA restored regulation, confirming that there is direct regulation by the sRNA. These results provide insight into the mechanisms by which Crp negatively regulates genes such as luxS and ompX and provide a link between catabolite repression, quorum sensing, and nitrogen assimilation in E. coli. JF - Journal of Bacteriology AU - Lay, Nicholas De AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, susang@helix.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 461 EP - 476 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 2 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Nutritional status KW - Translation KW - LuxS protein KW - quorum sensing KW - Cyclic AMP KW - Transcription KW - Ribosomes KW - Membrane proteins KW - Northern blotting KW - NAD KW - Gene regulation KW - Escherichia coli KW - Catabolite repression KW - Conserved sequence KW - Post-transcription KW - Major outer membrane protein KW - Mutation KW - N-octanoylhomoserine lactone KW - Nitrogen KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21501153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Crp-Activated+Small+Noncoding+Regulatory+RNA+CyaR+%28RyeE%29+Links+Nutritional+Status+to+Group+Behavior+%2C&rft.au=Lay%2C+Nicholas+De%3BGottesman%2C+Susan&rft.aulast=Lay&rft.aufirst=Nicholas&rft.date=2009-01-01&rft.volume=191&rft.issue=2&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01157-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Nutritional status; Translation; LuxS protein; quorum sensing; Cyclic AMP; Transcription; Ribosomes; Membrane proteins; Northern blotting; NAD; Gene regulation; Catabolite repression; Conserved sequence; Major outer membrane protein; Post-transcription; Mutation; N-octanoylhomoserine lactone; Nitrogen; Escherichia coli DO - http://dx.doi.org/10.1128/JB.01157-08 ER - TY - JOUR T1 - Trends in Prokaryotic Evolution Revealed by Comparison of Closely Related Bacterial and Archaeal Genomes AN - 21498589; 12493367 AB - In order to explore microevolutionary trends in bacteria and archaea, we constructed a data set of 41 alignable tight genome clusters (ATGCs). We show that the ratio of the medians of nonsynonymous to synonymous substitution rates (dN/dS) that is used as a measure of the purifying selection pressure on protein sequences is a stable characteristic of the ATGCs. In agreement with previous findings, parasitic bacteria, notwithstanding the sometimes dramatic genome shrinkage caused by gene loss, are typically subjected to relatively weak purifying selection, presumably owing to relatively small effective population sizes and frequent bottlenecks. However, no evidence of genome streamlining caused by strong selective pressure was found in any of the ATGCs. On the contrary, a significant positive correlation between the genome size, as well as gene size, and selective pressure was observed, although a variety of free-living prokaryotes with very close selective pressures span nearly the entire range of genome sizes. In addition, we examined the connections between the sequence evolution rate and other genomic features. Although gene order changes much faster than protein sequences during the evolution of prokaryotes, a strong positive correlation was observed between the QUOTATION_MARKrearrangement distanceQUOTATION_MARK and the amino acid distance, suggesting that at least some of the events leading to genome rearrangement are subjected to the same type of selective constraints as the evolution of amino acid sequences. JF - Journal of Bacteriology AU - Novichkov, Pavel S AU - Wolf, Yuri I AU - Dubchak, Inna AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, koonin@ncbi.nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 65 EP - 73 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 191 IS - 1 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Bacteria KW - Gene order KW - Data processing KW - Archaea KW - gene rearrangement KW - Atrophy KW - Prokaryotes KW - genomics KW - Evolution KW - A 01310:Products of Microorganisms KW - G 07770:Bacteria KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21498589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Trends+in+Prokaryotic+Evolution+Revealed+by+Comparison+of+Closely+Related+Bacterial+and+Archaeal+Genomes&rft.au=Novichkov%2C+Pavel+S%3BWolf%2C+Yuri+I%3BDubchak%2C+Inna%3BKoonin%2C+Eugene+V&rft.aulast=Novichkov&rft.aufirst=Pavel&rft.date=2009-01-01&rft.volume=191&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.01237-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Gene order; gene rearrangement; Atrophy; genomics; Prokaryotes; Evolution; Bacteria; Archaea DO - http://dx.doi.org/10.1128/JB.01237-08 ER - TY - JOUR T1 - The Human Papillomavirus Type 8 E2 Tethering Protein Targets the Ribosomal DNA Loci of Host Mitotic Chromosomes AN - 21490227; 12493861 AB - For many papillomaviruses, the viral protein E2 tethers the viral genome to the host mitotic chromosomes to ensure persistent, long-term maintenance of the genome during cell division. Our previous studies of E2 proteins from different genera of papillomaviruses have shown that they bind to different regions of the host chromosomes during mitosis. For example, bovine papillomavirus type 1 (BPV-1) E2 binds to all chromosomes as small speckles in complex with the cellular protein Brd4. In contrast, the human papillomavirus type 8 (HPV-8) E2 protein binds as large speckles at the pericentromeric regions of chromosomes. Here we show that these speckles do not contain Brd4, and unlike that of BPV-1, the N-terminal Brd4-interacting domain of HPV-8 E2 is not required for chromosome binding. In contrast to BPV-1 E2, the HPV-8 E2 protein targets the short arms of acrocentric mitotic chromosomes. Furthermore, the E2 protein interacts with the repeated ribosomal DNA genes found in this location and colocalizes with UBF, the RNA polymerase I transcription factor. Therefore, HPV-8 E2 genome tethering occurs by a Brd4-independent mechanism through a novel interaction with specific regions of mitotic chromosomes. Thus, a wide range of viruses have adopted the strategy of linking their genomes to host chromosomes, but individual viruses use different chromosomal targets. Characterization of these targets will enable the development of antiviral therapies to eliminate the viral genomes from infected cells. JF - Journal of Virology AU - Poddar, Atasi AU - Reed, Shawna C AU - McPhillips, Maria G AU - Spindler, Jonathan E AU - McBride, Alison A AD - Laboratory of Viral Diseases, NIAID, NIH, Bethesda, Maryland, amcbride@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 640 EP - 650 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 2 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - Chromosomes KW - Cell division KW - DNA-directed RNA polymerase KW - Transcription factors KW - Mitosis KW - Bovine papillomavirus KW - DNA KW - E2 protein KW - Repeated DNA sequences KW - Human papillomavirus KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21490227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+Human+Papillomavirus+Type+8+E2+Tethering+Protein+Targets+the+Ribosomal+DNA+Loci+of+Host+Mitotic+Chromosomes&rft.au=Poddar%2C+Atasi%3BReed%2C+Shawna+C%3BMcPhillips%2C+Maria+G%3BSpindler%2C+Jonathan+E%3BMcBride%2C+Alison+A&rft.aulast=Poddar&rft.aufirst=Atasi&rft.date=2009-01-01&rft.volume=83&rft.issue=2&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01936-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Genomes; DNA-directed RNA polymerase; Cell division; Chromosomes; Mitosis; Transcription factors; DNA; E2 protein; Repeated DNA sequences; Bovine papillomavirus; Human papillomavirus DO - http://dx.doi.org/10.1128/JVI.01936-08 ER - TY - JOUR T1 - Differential Sensitivity of QUOTATION_MARKOldQUOTATION_MARK versus QUOTATION_MARKNewQUOTATION_MARK APOBEC3G to Human Immunodeficiency Virus Type 1 Vif AN - 21480010; 12493845 AB - HIV-1 Vif counteracts the antiviral activity of APOBEC3G by inhibiting its encapsidation into virions. Here, we compared the relative sensitivity to Vif of APOBEC3G in stable HeLa cells containing APOBEC3G (HeLa-A3G cells) versus that of newly synthesized APOBEC3G. We observed that newly synthesized APOBEC3G was more sensitive to degradation than preexisting APOBEC3G. Nevertheless, preexisting and transiently expressed APOBEC3G were packaged with similar efficiencies into vif-deficient human immunodeficiency virus type 1 (HIV-1) virions, and Vif inhibited the encapsidation of both forms of APOBEC3G into HIV particles equally well. Our results suggest that HIV-1 Vif preferentially induces degradation of newly synthesized APOBEC3G but indiscriminately inhibits encapsidation of QUOTATION_MARKoldQUOTATION_MARK and QUOTATION_MARKnewQUOTATION_MARK APOBEC3G. JF - Journal of Virology AU - Goila-Gaur, Ritu AU - Khan, Mohammad A AU - Miyagi, Eri AU - Strebel, Klaus AD - Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, NIH, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, Maryland 20892-0460, kstrebel@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 1156 EP - 1160 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 83 IS - 2 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Human immunodeficiency virus 1 KW - Encapsidation KW - Antiviral activity KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21480010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Cluster+of+Cases+of+Nosocomial+Legionnaires+Disease+Linked+to+a+Contaminated+Hospital+Decorative+Water+Fountain&rft.au=Palmore%2C+Tara+N%3BStock%2C+Frida%3BWhite%2C+Margaret%3BBordner%2C+MaryAnn%3BMichelin%2C+Angela%3BBennett%2C+John+E%3BMurray%2C+Patrick+R%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=8&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F598855 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Virions; Encapsidation; Antiviral activity; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1128/JVI.01734-08 ER - TY - JOUR T1 - The Progressive Increase of Food Waste in America and Its Environmental Impact AN - 21469102; 11873182 AB - Food waste contributes to excess consumption of freshwater and fossil fuels which, along with methane and CO sub(2) emissions from decomposing food, impacts global climate change. Here, we calculate the energy content of nationwide food waste from the difference between the US food supply and the food consumed by the population. The latter was estimated using a validated mathematical model of metabolism relating body weight to the amount of food eaten. We found that US per capita food waste has progressively increased by a1450% since 1974 reaching more than 1400 kcal per person per day or 150 trillion kcal per year. Food waste now accounts for more than one quarter of the total freshwater consumption and a14300 million barrels of oil per year. JF - PLoS ONE AU - Hall, Kevin D AU - Guo, Juen AU - Dore, Michael AU - Chow, Carson C AU - Sorensen, Thorkild IA AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 4 IS - 11 KW - Ecology Abstracts KW - Methane KW - Fossil fuels KW - Freshwater environments KW - Food KW - Climatic changes KW - Wastes KW - Environmental impact KW - Carbon dioxide KW - Metabolism KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21469102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=The+Progressive+Increase+of+Food+Waste+in+America+and+Its+Environmental+Impact&rft.au=Hall%2C+Kevin+D%3BGuo%2C+Juen%3BDore%2C+Michael%3BChow%2C+Carson+C%3BSorensen%2C+Thorkild+IA&rft.aulast=Hall&rft.aufirst=Kevin&rft.date=2009-01-01&rft.volume=4&rft.issue=11&rft.spage=e7940&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0007940 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Methane; Fossil fuels; Freshwater environments; Food; Climatic changes; Environmental impact; Wastes; Carbon dioxide; Metabolism DO - http://dx.doi.org/10.1371/journal.pone.0007940 ER - TY - JOUR T1 - Visualization and Identification of IL-7 Producing Cells in Reporter Mice AN - 21461945; 11864162 AB - Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the Il7 locus. The construct lacked a signal peptide and ECFP (enhanced cyan fluorescent protein ) accumulated inside IL-7-producing stromal cells in thoracic thymus, cervical thymus and bone marrow. In thymus, an extensive reticular network of IL-7-containing processes extended from cortical and medullary epithelial cells, closely contacting thymocytes. Central memory CD8 T cells, which require IL-7 and home to bone marrow, physically associated with IL-7-producing cells as we demonstrate by intravital imaging. JF - PLoS ONE AU - Mazzucchelli, Renata I AU - Warming, Soren AU - Lawrence, Scott M AU - Ishii, Masaru AU - Abshari, Mehrnoosh AU - Washington, AValance AU - Feigenbaum, Lionel AU - Warner, Andrew C AU - Sims, Davis J AU - Li, Wen Qing AU - Hixon, Julie A AU - Gray, Daniel HD AU - Rich, Benjamin E AU - Morrow, Matthew AU - Anver, Miriam R AU - Cherry, James AU - Naf, Dieter AU - Sternberg, Lawrence R AU - McVicar, Daniel W AU - Farr, Andrew G AU - Germain, Ronald N AU - Rogers, Keith AU - Jenkins, Nancy A AU - Copeland, Neal G AU - Durum, Scott K AU - Unutmaz, Derya AD - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institute of Health, Frederick, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 4 IS - 11 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Interleukin 7 KW - Epithelial cells KW - stromal cells KW - Signal peptides KW - Thymus KW - Memory cells KW - Immunological memory KW - Bone marrow KW - Homeostasis KW - CD8 antigen KW - Transgenic mice KW - imaging KW - Bacterial artificial chromosomes KW - Thorax KW - Lymphocytes T KW - Thymocytes KW - J 02310:Genetics & Taxonomy KW - W 30910:Imaging KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21461945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Visualization+and+Identification+of+IL-7+Producing+Cells+in+Reporter+Mice&rft.au=Mazzucchelli%2C+Renata+I%3BWarming%2C+Soren%3BLawrence%2C+Scott+M%3BIshii%2C+Masaru%3BAbshari%2C+Mehrnoosh%3BWashington%2C+AValance%3BFeigenbaum%2C+Lionel%3BWarner%2C+Andrew+C%3BSims%2C+Davis+J%3BLi%2C+Wen+Qing%3BHixon%2C+Julie+A%3BGray%2C+Daniel+HD%3BRich%2C+Benjamin+E%3BMorrow%2C+Matthew%3BAnver%2C+Miriam+R%3BCherry%2C+James%3BNaf%2C+Dieter%3BSternberg%2C+Lawrence+R%3BMcVicar%2C+Daniel+W%3BFarr%2C+Andrew+G%3BGermain%2C+Ronald+N%3BRogers%2C+Keith%3BJenkins%2C+Nancy+A%3BCopeland%2C+Neal+G%3BDurum%2C+Scott+K%3BUnutmaz%2C+Derya&rft.aulast=Mazzucchelli&rft.aufirst=Renata&rft.date=2009-01-01&rft.volume=4&rft.issue=11&rft.spage=e7637&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0007637 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Interleukin 7; stromal cells; Thymus; Signal peptides; Bone marrow; Immunological memory; Memory cells; CD8 antigen; Homeostasis; Transgenic mice; imaging; Bacterial artificial chromosomes; Lymphocytes T; Thorax; Thymocytes DO - http://dx.doi.org/10.1371/journal.pone.0007637 ER - TY - JOUR T1 - Anthrax Toxin Uptake by Primary Immune Cells as Determined with a Lethal Factor-I2-Lactamase Fusion Protein AN - 21451447; 11865703 AB - Background To initiate infection, Bacillus anthracis needs to overcome the host innate immune system. Anthrax toxin, a major virulence factor of B. anthracis, impairs both the innate and adaptive immune systems and is important in the establishment of anthrax infections. Methodology/Principal Findings To measure the ability of anthrax toxin to target immune cells, studies were performed using a fusion of the anthrax toxin lethal factor (LF) N-terminal domain (LFn, aa 1a254) with I2-lactamase (LFnBLA). This protein reports on the ability of the anthrax toxin protective antigen (PA) to mediate LF delivery into cells. Primary immune cells prepared from mouse spleens were used in conjunction with flow cytometry to assess cleavage and resulting FRET disruption of a fluorescent I2-lactamase substrate, CCF2/AM. In spleen cell suspensions, the macrophages, dendritic cells, and B cells showed about 75% FRET disruption of CCF2/AM due to cleavage by the PAadelivered LFnBLA. LFnBLA delivery into CD4+ and CD8+ T cells was lower, with 40% FRET disruption. When the analyses were done on purified samples of individual cell types, similar results were obtained, with T cells again having lower LFnBLA delivery than macrophages, dendritic cells, and B cells. Relative expression levels of the toxin receptors CMG2 and TEM8 on these cells were determined by real-time PCR. Expression of CMG2 was about 1.5-fold higher in CD8+ cells than in CD4+ and B cells, and 2.5-fold higher than in macrophages. Conclusions/Significance Anthrax toxin entry and activity differs among immune cells. Macrophages, dendritic cells, and B cells displayed higher LFnBLA activity than CD4+ and CD8+ T cells in both spleen cell suspension and the purified samples of individual cell types. Expression of anthrax toxin receptor CMG2 is higher in CD4+ and CD8+ T cells, which is not correlated to the intracellular LFnBLA activity. JF - PLoS ONE AU - Hu, Haijing AU - Leppla, Stephen H AU - Ratner, Adam J AD - Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 4 IS - 11 KW - Toxicology Abstracts; Immunology Abstracts KW - Cell suspensions KW - Macrophages KW - virulence factors KW - Lymphocytes B KW - Immune system KW - Lethal factor KW - protective antigen KW - Spleen KW - fluorescence resonance energy transfer KW - CD8 antigen KW - Bacillus anthracis KW - Infection KW - Toxins KW - Flow cytometry KW - Toxin A KW - Dendritic cells KW - CD4 antigen KW - Lymphocytes T KW - Anthrax KW - Polymerase chain reaction KW - Fusion protein KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21451447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Anthrax+Toxin+Uptake+by+Primary+Immune+Cells+as+Determined+with+a+Lethal+Factor-I2-Lactamase+Fusion+Protein&rft.au=Hu%2C+Haijing%3BLeppla%2C+Stephen+H%3BRatner%2C+Adam+J&rft.aulast=Hu&rft.aufirst=Haijing&rft.date=2009-01-01&rft.volume=4&rft.issue=11&rft.spage=e7946&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0007946 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell suspensions; virulence factors; Lymphocytes B; Lethal factor; Immune system; protective antigen; fluorescence resonance energy transfer; Spleen; CD8 antigen; Infection; Toxins; Toxin A; Flow cytometry; Dendritic cells; CD4 antigen; Lymphocytes T; Polymerase chain reaction; Anthrax; Fusion protein; Bacillus anthracis DO - http://dx.doi.org/10.1371/journal.pone.0007946 ER - TY - JOUR T1 - Identifying rheumatoid arthritis susceptibility genes using high-dimensional methods AN - 21445903; 11866173 AB - Although several genes (including a strong effect in the human leukocyte antigen (HLA) region) and some environmental factors have been implicated to cause susceptibility to rheumatoid arthritis (RA), the etiology of the disease is not completely understood. The ability to screen the entire genome for association to complex diseases has great potential for identifying gene effects. However, the efficiency of gene detection in this situation may be improved by methods specifically designed for high-dimensional data. The aim of this study was to compare how three different statistical approaches, multifactor dimensionality reduction (MDR), random forests (RF), and an omnibus approach, worked in identifying gene effects (including gene-gene interaction) associated with RA. We developed a test set of genes based on previous linkage and association findings and tested all three methods. In the presence of the HLA shared-epitope factor, other genes showed weaker effects. All three methods detected SNPs in PTPN22 and TRAF1-C5 as being important. But we did not detect any new genes in this study. We conclude that the three high-dimensional methods are useful as an initial screening for gene associations to identify promising genes for further modeling and additional replication studies. JF - BMC Proceedings AU - Liang, Xueying AU - Gao, Ying AU - Lam, Tram K AU - Li, Qizhai AU - Falk, Cathy AU - Yang, Xiaohong R AU - Goldstein, Alisa M AU - Goldin, Lynn R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, Maryland 20892, USA, liangx2@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S79 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 3 IS - Suppl 7 KW - Calcium & Calcified Tissue Abstracts; Immunology Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Histocompatibility antigen HLA KW - Genomes KW - Rheumatoid arthritis KW - Etiology KW - Statistics KW - Data processing KW - Replication KW - Single-nucleotide polymorphism KW - Forests KW - Environmental factors KW - Protein-tyrosine-phosphatase KW - G 07720:Immunogenetics KW - T 2055:Laboratory Methods KW - F 06930:Autoimmunity KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21445903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Successful+Mandatory+Influenza+Vaccination+Campaign+Using+an+Innovative+Electronic+Tracking+System&rft.au=Palmore%2C+Tara+N%3BVandersluis%2C+JPatrick%3BMorris%2C+Joan%3BMichelin%2C+Angela%3BRuprecht%3B%2C+Lisa+M%3BSchmitt%2C+James+M%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=12&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F648084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Genomes; Histocompatibility antigen HLA; Etiology; Rheumatoid arthritis; Data processing; Statistics; Single-nucleotide polymorphism; Replication; Forests; Environmental factors; Protein-tyrosine-phosphatase ER - TY - JOUR T1 - The potential for automated question answering in the context of genomic medicine: an assessment of existing resources and properties of answers AN - 21442870; 11861941 AB - Knowledge gained in studies of genetic disorders is reported in a growing body of biomedical literature containing reports of genetic variation in individuals that map to medical conditions and/or response to therapy. These scientific discoveries need to be translated into practical applications to optimize patient care. Translating research into practice can be facilitated by supplying clinicians with research evidence. We assessed the role of existing tools in extracting answers to translational research questions in the area of genomic medicine. We: evaluate the coverage of translational research terms in the Unified Medical Language Systems (UMLS) Metathesaurus; determine where answers are most often found in full-text articles; and determine common answer patterns. Findings suggest that we will be able to leverage the UMLS in development of natural language processing algorithms for automated extraction of answers to translational research questions from biomedical text in the area of genomic medicine. JF - BMC Bioinformatics AU - Overby, Casey Lynnette AU - Tarczy-Hornoch, Peter AU - Demner-Fushman, Dina AD - Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, BHHS, Bethesda, MD, USA, ddemner@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - S8 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 IS - Suppl 9 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Algorithms KW - Genetic diversity KW - Language KW - Bioinformatics KW - genomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21442870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Intensive+care+unit-acquired+neuromyopathy+and+corticosteroids+in+survivors+of+persistent+ARDS&rft.au=Hough%2C+Catherine+L%3BSteinberg%2C+Kenneth+P%3BTaylor+Thompson%2C+B%3BRubenfeld%2C+Gordon+D%3BHudson%2C+Leonard+D&rft.aulast=Hough&rft.aufirst=Catherine&rft.date=2009-01-01&rft.volume=35&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-008-1304-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Translation; genomics; Language; Algorithms; Genetic diversity; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-10-S9-S8 ER - TY - JOUR T1 - Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo AN - 21439564; 10917082 AB - Anthrax toxin, a major virulence factor of Bacillus anthracis, gains entry into target cells by binding to either of 2 von Willebrand factor A domain-containing proteins, tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2). The wide tissue expression of TEM8 and CMG2 suggest that both receptors could play a role in anthrax pathogenesis. To explore the roles of TEM8 and CMG2 in normal physiology, as well as in anthrax pathogenesis, we generated TEM8- and CMG2-null mice and TEM8/CMG2 double-null mice by deleting TEM8 and CMG2 transmembrane domains. TEM8 and CMG2 were found to be dispensable for mouse development and life, but both are essential in female reproduction in mice. We found that the lethality of anthrax toxin for mice is mostly mediated by CMG2 and that TEM8 plays only a minor role. This is likely because anthrax toxin has approximately 11-fold higher affinity for CMG2 than for TEM8. Finally, the CMG2-null mice are also shown to be highly resistant to B. anthracis spore infection, attesting to the importance of both anthrax toxin and CMG2 in anthrax infections. JF - Proceedings of the National Academy of Sciences, USA AU - Liu, Shihui AU - Crown, Devorah AU - Miller-Randolph, Sharmina AU - Moayeri, Mahtab AU - Wang, Hailun AU - Hu, Haijing AU - Morley, Thomas AU - Leppla, Stephen H AD - Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, sleppla@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 12424 EP - 12429 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 30 SN - 0027-8424, 0027-8424 KW - Toxicology Abstracts KW - edema toxin KW - lethal toxin KW - tumor endothelium marker-8 KW - Von Willebrand factor KW - virulence factors KW - Morphogenesis KW - Tumors KW - Bacillus anthracis KW - Infection KW - Transmembrane domains KW - Toxin A KW - Lethality KW - Endothelium KW - Anthrax KW - Reproduction KW - Spores KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21439564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Capillary+morphogenesis+protein-2+is+the+major+receptor+mediating+lethality+of+anthrax+toxin+in+vivo&rft.au=Liu%2C+Shihui%3BCrown%2C+Devorah%3BMiller-Randolph%2C+Sharmina%3BMoayeri%2C+Mahtab%3BWang%2C+Hailun%3BHu%2C+Haijing%3BMorley%2C+Thomas%3BLeppla%2C+Stephen+H&rft.aulast=Liu&rft.aufirst=Shihui&rft.date=2009-01-01&rft.volume=106&rft.issue=30&rft.spage=12424&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0905409106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Toxin A; Von Willebrand factor; Lethality; virulence factors; Endothelium; Morphogenesis; Anthrax; Reproduction; Tumors; Spores; Transmembrane domains; Infection; Bacillus anthracis DO - http://dx.doi.org/10.1073/pnas.0905409106 ER - TY - JOUR T1 - A Successful Mandatory Influenza Vaccination Campaign Using an Innovative Electronic Tracking System AN - 21333289; 11839565 AB - Background. Although influenza vaccination of healthcare workers reduces influenza-like illness and overall mortality among patients, national rates of vaccination for healthcare providers are unacceptably low. We report the implementation of a new mandatory vaccination policy by means of a streamlined electronic enrollment and vaccination tracking system at the National Institutes of Health (NIH) Clinical Center. Objective. To evaluate the outcome of a new mandatory staff influenza vaccination program. Methods. A new hospital policy endorsed by all the component NIH institutes and the Clinical Center departments mandated that employees who have patient contact either be vaccinated annually against influenza or sign a declination specifying the reason(s) for refusal. Those who fail to comply would be required to appear before the Medical Executive Committee to explain their rationale. We collected in a database the names of all physician and nonphysician staff who had patient contact. When a staff member either was vaccinated or declined vaccination, a simple system of badge scanning and bar-coded data entry captured essential data. The database was continuously updated, and it provided a list of noncompliant employees with whom to follow up. Results. By February 12, 2009, all 2,754 identified patient-care employees either were vaccinated or formally declined vaccination. Among those, 2,424 (88%) were vaccinated either at the NIH or elsewhere, 36 (1.3%) reported medical contraindications, and 294 (10.7%) declined vaccination for other reasons. Among the 294 employees without medical contraindications who declined, the most frequent reason given for declination was concern about side effects. Conclusions. Implementation of a novel vaccination tracking process and a hospital policy requiring influenza vaccination or declination yielded dramatic improvement in healthcare worker vaccination rates and likely will result in increased patient safety in our hospital. JF - Infection Control and Hospital Epidemiology AU - Palmore, Tara N AU - Vandersluis, JPatrick AU - Morris, Joan AU - Michelin, Angela AU - Ruprecht AU - , Lisa M AU - Schmitt, James M AU - Henderson, David K AD - Clinical Center and the Occupational Medical Service, Division of Occupational Health and Safety, National Institutes of Health, Bethesda, Maryland, dkh@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 1137 EP - 1142 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 12 SN - 0899-823X, 0899-823X KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21333289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Successful+Mandatory+Influenza+Vaccination+Campaign+Using+an+Innovative+Electronic+Tracking+System&rft.au=Palmore%2C+Tara+N%3BVandersluis%2C+JPatrick%3BMorris%2C+Joan%3BMichelin%2C+Angela%3BRuprecht%3B%2C+Lisa+M%3BSchmitt%2C+James+M%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=12&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F648084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1086/648084 ER - TY - JOUR T1 - Malaria Control, Elimination, and Eradication: The Role of the Evolving Biomedical Research Agenda AN - 21330767; 11839604 JF - Journal of Infectious Diseases AU - Hall, BFenton AU - Fauci, Anthony S AD - Parasitology and International Programs Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, lhall@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1639 EP - 1643 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 11 SN - 0022-1899, 0022-1899 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources KW - Human diseases KW - Infectious diseases KW - Malaria KW - Public health KW - K 03400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21330767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Malaria+Control%2C+Elimination%2C+and+Eradication%3A+The+Role+of+the+Evolving+Biomedical+Research+Agenda&rft.au=Hall%2C+BFenton%3BFauci%2C+Anthony+S&rft.aulast=Hall&rft.aufirst=BFenton&rft.date=2009-01-01&rft.volume=200&rft.issue=11&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F646611 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Human diseases; Infectious diseases; Malaria; Public health DO - http://dx.doi.org/10.1086/646611 ER - TY - JOUR T1 - Direct and Indirect Impairment of Human Dendritic Cell Function by Virulent Francisella tularensis Schu S4 AN - 21293232; 12510977 AB - The gram-negative, facultative intracellular bacterium Francisella tularensis causes acute, lethal pneumonic disease following infection with only 10 CFU. The mechanisms used by the bacterium to accomplish this in humans are unknown. Here, we demonstrate that virulent, type A F. tularensis strain Schu S4 efficiently infects and replicates in human myeloid dendritic cells (DCs). Despite exponential replication over time, Schu S4 failed to stimulate transforming growth factor ?, interleukin-10 (IL-10), IL-6, IL-1?, IL-12, tumor necrosis factor alpha, alpha interferon (IFN-), and IFN-? throughout the course of infection. Schu S4 also suppressed the ability of directly infected DCs to respond to different Toll-like receptor agonists. Furthermore, we also observed functional inhibition of uninfected bystander cells. This inhibition was mediated, in part, by a heat-stable bacterial component. Lipopolysaccharide (LPS) from Schu S4 was present in Schu S4-conditioned medium. However, Schu S4 LPS was weakly inflammatory and failed to induce suppression of DCs at concentrations below 10 kg/ml, and depletion of Schu S4 LPS did not significantly alleviate the inhibitory effect of Schu S4-conditioned medium in uninfected human DCs. Together, these data show that type A F. tularensis interferes with the ability of a central cell type of the immune system, DCs, to alert the host of infection both intra- and extracellularly. This suggests that immune dysregulation by F. tularensis operates on a broader and more comprehensive scale than previously appreciated. JF - Infection and Immunity AU - Chase, Jennifer C AU - Celli, Jean AU - Bosio, Catharine M AD - Immunity to Pulmonary Pathogens Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, bosioc@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 180 EP - 195 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Colony-forming cells KW - Data processing KW - Dendritic cells KW - Immune system KW - Infection KW - Inflammation KW - Interferon KW - Interleukin 1 KW - Interleukin 10 KW - Interleukin 12 KW - Interleukin 6 KW - Lipopolysaccharides KW - Replication KW - Thermal stability KW - Toll-like receptors KW - Transforming growth factor KW - Tumor necrosis factor-a KW - a-Interferon KW - Francisella tularensis KW - A 01490:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21293232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Direct+and+Indirect+Impairment+of+Human+Dendritic+Cell+Function+by+Virulent+Francisella+tularensis+Schu+S4&rft.au=Chase%2C+Jennifer+C%3BCelli%2C+Jean%3BBosio%2C+Catharine+M&rft.aulast=Chase&rft.aufirst=Jennifer&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00879-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Transforming growth factor; Data processing; Replication; Immune system; Interleukin 1; Infection; Tumor necrosis factor-a; Interleukin 10; Inflammation; Dendritic cells; Interferon; Interleukin 12; Colony-forming cells; Lipopolysaccharides; Thermal stability; a-Interferon; Toll-like receptors; Francisella tularensis DO - http://dx.doi.org/10.1128/IAI.00879-08 ER - TY - JOUR T1 - Total Pesticide Exposure Calculation among Vegetable Farmers in Benguet, Philippines AN - 21282119; 11829330 AB - This was a cross-sectional study that investigated pesticide exposure and its risk factors targeting vegetable farmers selected through cluster sampling. The sampling size calculated with [[PQ_REPLACE:[math]]]P=.05 was 211 vegetable farmers and 37 farms. The mean usage of pesticide was 21.35 liters. Risk factors included damaged backpack sprayer (34.7%), spills on hands (31.8%), and spraying against the wind (58%). The top 3 pesticides used were pyrethroid (46.4%), organophosphates (24.2%), and carbamates (21.3%). Those who were exposed to fungicides and insecticides also had higher total pesticide exposure. Furthermore, a farmer who was a pesticide applicator, mixer, loader, and who had not been given instructions through training was at risk of having higher pesticide exposure. The most prevalent symptoms were headache (64.1%), muscle pain (61.1%), cough (45.5%), weakness (42.4%), eye pain (39.9%), chest pain (37.4%), and eye redness (33.8%). The data can be used for the formulation of an integrated program on safety and health in the vegetable industry. JF - Journal of Environmental and Public Health AU - Lu, Jinky Leilanie AD - National Institutes of Health University of the Philippines Manila Ermita, Manila 1100, jinky_lu@yahoo.com Y1 - 2009 PY - 2009 DA - 2009 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2009 KW - Environmental Engineering Abstracts; Environment Abstracts KW - Philippines KW - Eye KW - Training KW - Organophosphates KW - Sprays KW - Muscles KW - pain KW - farms KW - Fungicides KW - Pesticides KW - EE 10:General Environmental Engineering KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21282119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+and+Public+Health&rft.atitle=Total+Pesticide+Exposure+Calculation+among+Vegetable+Farmers+in+Benguet%2C+Philippines&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2009-01-01&rft.volume=2009&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+and+Public+Health&rft.issn=1687-9813&rft_id=info:doi/10.1155%2F2009%2F412054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Philippines; Pesticides; pain; Eye; Sprays; Organophosphates; Muscles; Fungicides; farms; Training DO - http://dx.doi.org/10.1155/2009/412054 ER - TY - JOUR T1 - Sustained Activation of Akt and Erk1/2 Is Required for Coxiella burnetii Antiapoptotic Activity AN - 21279246; 12511001 AB - Coxiella burnetii is an obligate intracellular bacterial pathogen that directs biogenesis of a lysosome-like, parasitophorous vacuole in mammalian cells. We recently reported that C. burnetii inhibits apoptotic cell death in macrophages, presumably as a mechanism to sustain the host for completion of its lengthy infectious cycle. In the current study, we further investigated C. burnetii manipulation of host cell signaling and apoptosis by examining the effect of C. burnetii infection on activation of 15 host proteins involved in stress responses, cytokine production, and apoptosis. C. burnetii infection of THP-1 human macrophage-like cells caused increased levels of phosphorylated c-Jun, Hsp27, Jun N-terminal protein kinase, and p38 at 2 h postinfection (hpi), and this activation rapidly decreased to near basal levels by 24 hpi. The prosurvival kinases Akt and Erk1/2 (extracellular signal-regulated kinases 1 and 2) were also activated at 2 to 6 hpi; however, the phosphorylation of these proteins increased coincident with C. burnetii replication through at least 72 hpi. Sustained phosphorylation of Akt and Erk1/2 was abolished by treatment of infected cells with rifampin, indicating their activation is a C. burnetii-directed event requiring pathogen RNA synthesis. Moreover, pharmacological inhibition of Akt or Erk1/2 significantly decreased C. burnetii antiapoptotic activity. Collectively, these results indicate the importance of C. burnetii modulation of host signaling and demonstrate a critical role for Akt and Erk1/2 in successful intracellular parasitism and maintenance of host cell viability. JF - Infection and Immunity AU - Voth, Daniel E AU - Heinzen, Robert A Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 205 EP - 213 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - AKT protein KW - Apoptosis KW - Cell activation KW - Cytokines KW - Extracellular signal-regulated kinase KW - Hsp27 protein KW - Infection KW - Intracellular signalling KW - Macrophages KW - Mammalian cells KW - Parasitism KW - Pathogens KW - Phosphorylation KW - Protein kinase KW - Replication KW - Rifampin KW - Signal transduction KW - Transcription KW - Transcription factors KW - c-Jun protein KW - parasitophorous vacuole KW - Coxiella burnetii KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21279246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Sustained+Activation+of+Akt+and+Erk1%2F2+Is+Required+for+Coxiella+burnetii+Antiapoptotic+Activity&rft.au=Voth%2C+Daniel+E%3BHeinzen%2C+Robert+A&rft.aulast=Voth&rft.aufirst=Daniel&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01124-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Macrophages; Intracellular signalling; Apoptosis; Replication; Transcription; Pathogens; Infection; c-Jun protein; Parasitism; Cell activation; parasitophorous vacuole; Extracellular signal-regulated kinase; Rifampin; Mammalian cells; Phosphorylation; Transcription factors; Hsp27 protein; AKT protein; Cytokines; Protein kinase; Signal transduction; Coxiella burnetii DO - http://dx.doi.org/10.1128/IAI.01124-08 ER - TY - JOUR T1 - Perspective on Malaria Eradication: Is Eradication Possible without Modifying the Mosquito? AN - 21274813; 11839605 JF - Journal of Infectious Diseases AU - Miller, Louis H AU - Pierce, Susan K AD - The Malaria Vaccine Development Branch and Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, lomiller@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1644 EP - 1645 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 11 SN - 0022-1899, 0022-1899 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; Entomology Abstracts KW - Human diseases KW - Infectious diseases KW - Culicidae KW - Malaria KW - Aquatic insects KW - Public health KW - K 03400:Human Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21274813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Perspective+on+Malaria+Eradication%3A+Is+Eradication+Possible+without+Modifying+the+Mosquito%3F&rft.au=Miller%2C+Louis+H%3BPierce%2C+Susan+K&rft.aulast=Miller&rft.aufirst=Louis&rft.date=2009-01-01&rft.volume=200&rft.issue=11&rft.spage=1644&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F646612 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Human diseases; Infectious diseases; Malaria; Aquatic insects; Public health; Culicidae DO - http://dx.doi.org/10.1086/646612 ER - TY - JOUR T1 - Interaction of an autotransporter passenger domain with BamA during its translocation across the bacterial outer membrane AN - 21242980; 11360889 AB - Autotransporters are a superfamily of virulence factors produced by Gram-negative bacteria consisting of a large N-terminalextracellular domain ('passenger domain-) and a C-terminal b barrel domain ('b domain-). The mechanism by which the passengerdomain is translocated across the outer membrane (OM) is unknown. Here we show that the insertion of a small linker into thepassenger domain of the Escherichia coli O157:H7 autotransporter EspP effectively creates a translocation intermediate by transiently stalling translocation nearthe site of the insertion. Using a site-specific photocrosslinking approach, we found that residues adjacent to the stallpoint interact with BamA, a component of a heterooligomeric complex (Bam complex) that catalyzes OM protein assembly, andthat residues closer to the EspP N terminus interact with the periplasmic chaperones SurA and Skp. The EspP-BamA interactionwas short-lived and could be detected only when passenger domain translocation was stalled. These results support a modelin which molecular chaperones prevent misfolding of the passenger domain before its secretion and the Bam complex catalyzesboth the integration of the b domain into the OM and the translocation of the passenger domain across the OM in a C- to N-terminaldirection. JF - Proceedings of the National Academy of Sciences, USA AU - Ieva, Raffaele AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, harris_bernstein@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 19120 EP - 19125 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 45 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - autotransporter KW - Bam complex KW - outer membrane KW - protein secretion KW - virulence factors KW - Integration KW - Secretion KW - Gram-negative bacteria KW - Outer membranes KW - Escherichia coli KW - Chaperones KW - Translocation KW - J 02330:Biochemistry KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21242980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Interaction+of+an+autotransporter+passenger+domain+with+BamA+during+its+translocation+across+the+bacterial+outer+membrane&rft.au=Ieva%2C+Raffaele%3BBernstein%2C+Harris+D&rft.aulast=Ieva&rft.aufirst=Raffaele&rft.date=2009-01-01&rft.volume=106&rft.issue=45&rft.spage=19120&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0907912106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Integration; virulence factors; Gram-negative bacteria; Secretion; Outer membranes; Chaperones; Translocation; Escherichia coli DO - http://dx.doi.org/10.1073/pnas.0907912106 ER - TY - JOUR T1 - Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine AN - 21240269; 11360848 AB - Chloroquine (CQ) resistance (CQR) in Plasmodium falciparum originated from at least six foci in South America, Asia, and Oceania. Malaria parasites from these locations exhibit contrastingresistance phenotypes that are distinguished by point mutations and microsatellite polymorphisms in and near the CQR transportergene, pfcrt, and the multidrug resistance transporter gene, pfmdr1. Amodiaquine (AQ), a 4-aminoquinoline related to CQ, is recommended and often used successfully against CQ-resistant P. falciparum in Africa, but it is largely ineffective across large regions of South America. The relationship of different pfcrt and pfmdr1 combinations to these drug-resistant phenotypes has been unclear. In two P. falciparum genetic crosses, particular pfcrt and pfmdr1 alleles from South America interact to yield greater levels of resistance to monodesethylamodiaquine (MDAQ; the active metaboliteof AQ) than to CQ, whereas a pfcrt allele from Southeast Asia and Africa is linked to greater CQ than MDAQ resistance with all partner pfmdr1 alleles. These results, together with (i) available haplotype data from other parasites; (ii) evidence for an emerging focus of AQ resistance in Tanzania; (iii) the persistence of 4-aminoquinoline-resistant parasites in South America, where CQ and AQ use is largely discontinued, suggestthat different histories of drug use on the two continents have driven the selection of distinct suites of pfcrt and pfmdr1 mutations. Increasing use of AQ in Africa poses the threat of a selective sweep of highly AQ-resistant, CQ-resistant parasiteswith pfcrt and pfmdr1 mutations that are as advantaged and persistent as in South America. JF - Proceedings of the National Academy of Sciences, USA AU - Sa, Juliana Martha AU - Twu, Olivia AU - Hayton, Karen AU - Reyes, Sahily AU - Fay, Michael P AU - Ringwald, Pascal AU - Wellems, Thomas E Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 18883 EP - 18889 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 45 SN - 0027-8424, 0027-8424 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources KW - malaria KW - pfcrt KW - pfmdr1 KW - Parasites KW - Human diseases KW - Allelles KW - Drug resistance KW - Gene polymorphism KW - Nucleotide sequence KW - Malaria KW - Phenotypes KW - Public health KW - Haplotypes KW - INW, Asia KW - Drugs KW - Amodiaquine KW - Data processing KW - Mutations KW - Point mutation KW - Microsatellites KW - Chloroquine KW - ISW, Tanzania KW - Plasmodium falciparum KW - ASW, South America KW - DNA KW - Multidrug resistance KW - ISEW, Southeast Asia KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21240269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Geographic+patterns+of+Plasmodium+falciparum+drug+resistance+distinguished+by+differential+responses+to+amodiaquine+and+chloroquine&rft.au=Sa%2C+Juliana+Martha%3BTwu%2C+Olivia%3BHayton%2C+Karen%3BReyes%2C+Sahily%3BFay%2C+Michael+P%3BRingwald%2C+Pascal%3BWellems%2C+Thomas+E&rft.aulast=Sa&rft.aufirst=Juliana&rft.date=2009-01-01&rft.volume=106&rft.issue=45&rft.spage=18883&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0911317106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Mutations; Allelles; Nucleotide sequence; DNA; Drugs; Phenotypes; Public health; Amodiaquine; Data processing; Haplotypes; Gene polymorphism; Drug resistance; Point mutation; Microsatellites; Chloroquine; Malaria; Multidrug resistance; Plasmodium falciparum; ASW, South America; INW, Asia; ISW, Tanzania; ISEW, Southeast Asia DO - http://dx.doi.org/10.1073/pnas.0911317106 ER - TY - JOUR T1 - The Effect of Exercise Intensity on Serum Leptin and C-Reactive Protein Levels AN - 21233223; 11774511 AB - Recently, serum leptin and C-reactive protein (CRP) levels have been regarded as independent predictive factors for heart disease. Although exercise intensity and duration may influence leptin and CRP concentrations, few studies have investigated this. In addition, leptin and CRP exhibit trends (downward and upward, respectively) after an acute bout of aerobic exercise. There seems to be a negative association between them, which may differ from the baseline; however, no study has tested this assumption. Therefore, we investigated the effect of exercise intensity on serum leptin and CRP levels and compared changes and differences in both relationships with different exercise intensities. In addition to the VO sub(2max) test, 13 male subjects (21.5 c 1.8 years old, 18.5 c 4.0%body fat, 55.0 c 3.8 mL ; kg super(-1) ; min super(-1) VO sub(2max)) exercised at two other exercise intensities (85% VO sub(2max) and 65% VO sub(2max)) in a randomized order. Blood samples were collected before and immediately after each trial to analyze pre- and post-exercise leptin and CRP concentrations in the three trials. While there were no significant differences in post-exercise leptin and CRP levels among the different exercise intensities, there were significant differences between leptin and CRP concentrations before and after exercise bouts corresponding to 65% and 85% VO sub(2max). In addition, post-exercise leptin and CRP levels were not associated. The results of this study suggest that leptin and CRP do not differ among different exercise intensities. Alteration in CRP and body fat percentage did not contribute to the change in leptin in these acute exercise models. JF - Journal of Exercise Science and Fitness AU - Tsao, T-H AU - Hsu, C-H AU - Yang, C-B AU - Liou, T-L AD - Department of Recreation Sports and Health Promotion, National Pingtung University of Science and Technology, 1 Hseuh-Fu Road, Nei-Pu Township, Pingtung 912, TAIWAN, thtsao@mail.npust.edu.tw Y1 - 2009 PY - 2009 DA - 2009 SP - 98 EP - 103 VL - 7 IS - 2 SN - 1728-869X, 1728-869X KW - Physical Education Index KW - Fitness KW - Blood KW - Aerobics KW - Exercise (intensity) KW - Analysis KW - Proteins KW - Hormones KW - Maximum oxygen consumption KW - Heart diseases KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21233223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exercise+Science+and+Fitness&rft.atitle=The+Effect+of+Exercise+Intensity+on+Serum+Leptin+and+C-Reactive+Protein+Levels&rft.au=Tsao%2C+T-H%3BHsu%2C+C-H%3BYang%2C+C-B%3BLiou%2C+T-L&rft.aulast=Tsao&rft.aufirst=T-H&rft.date=2009-01-01&rft.volume=7&rft.issue=2&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exercise+Science+and+Fitness&rft.issn=1728869X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2010-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Fitness; Blood; Aerobics; Exercise (intensity); Analysis; Proteins; Maximum oxygen consumption; Hormones; Heart diseases ER - TY - JOUR T1 - Human Type 1 and 17 Responses in Latent Tuberculosis Are Modulated by Coincident Filarial Infection through Cytotoxic T Lymphocyte Antigen-4 and Programmed Death-1 AN - 21222190; 11189284 AB - Mycobacterium tuberculosis and filarial coinfection is highly prevalent, and the presence of a tissue-invasive helminth may modulate the predominant type 1 T helper (Th1; interferon [IFN]--mediated) response needed to control M. tuberculosis infection. By analyzing the cellular responses to mycobacterial antigens in patients who had latent tuberculosis with or without filarial infection, we were able to demonstrate that filarial infection coincident with M. tuberculosis infection significantly diminishes M. tuberculosis-specific Th1 (interleukin [IL]-12 and IFN-) and type 17 T helper (Th17; IL-23 and IL-17) responses related to increased expression of cytotoxic T lymphocyte antigen (CTLA)-4 and programmed death (PD)-1. Blockade of CTLA-4 restored production of both IFN- and IL-17, whereas PD-1 blockade restored IFN- production only. Thus, coincident filarial infection exerted a profound inhibitory effect on protective mycobacteria-specific Th1 and Th17 responses in latent tuberculosis, suggesting a mechanism by which concomitant filarial (and other systemic helminth) infections predispose to the development of active tuberculosis in humans. JF - Journal of Infectious Diseases AU - Babu, Subash AU - Bhat, Sajid Q AU - Kumar, NPavan AU - Jayantasri, S AU - Rukmani, S AU - Kumaran, Paul AU - Gopi, P G AU - Kolappan, C AU - Kumaraswami, V AU - Nutman, Thomas B AD - National Institutes of Health-International Center for Excellence in Research and Tuberculosis Research Center, Chennai, India, sbabu@mail.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 288 EP - 298 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 2 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Interferon KW - PD-1 protein KW - Cytotoxicity KW - Interleukin 23 KW - CTLA-4 protein KW - Helper cells KW - Interleukin 17 KW - Lymphocytes T KW - Tuberculosis KW - Infection KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21222190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Human+Type+1+and+17+Responses+in+Latent+Tuberculosis+Are+Modulated+by+Coincident+Filarial+Infection+through+Cytotoxic+T+Lymphocyte+Antigen-4+and+Programmed+Death-1&rft.au=Babu%2C+Subash%3BBhat%2C+Sajid+Q%3BKumar%2C+NPavan%3BJayantasri%2C+S%3BRukmani%2C+S%3BKumaran%2C+Paul%3BGopi%2C+P+G%3BKolappan%2C+C%3BKumaraswami%2C+V%3BNutman%2C+Thomas+B&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2009-01-01&rft.volume=200&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - PD-1 protein; Interferon; Cytotoxicity; Interleukin 23; CTLA-4 protein; Interleukin 17; Helper cells; Lymphocytes T; Tuberculosis; Infection; Mycobacterium tuberculosis ER - TY - JOUR T1 - Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes AN - 21217674; 11260934 AB - Celiac disease (CD) is an autoimmune inflammatory disease with a relatively high prevalence especially in the western hemisphere. A strong genetic component is involved in the pathogenesis of CD with virtually all individuals that develop the disease carrying HLA-DQ alleles that encode specific HLA-DQ2 or HLA-DQ8 heterodimers. Consumption of cereals rich in gluten triggers a chronic intestinal inflammation in genetically susceptible individuals leading to the development of CD. Emerging evidence has implicated a central role for IL-15 in the orchestration and perpetuation of inflammation and tissue destruction in CD. Therefore, IL-15 represents an attractive target for development of new therapies for CD. Transgenic mice that express human IL-15 specifically in enterocytes (T3 super(b)-hIL-15 Tg mice) develop villous atrophy and severe duodeno-jejunal inflammation with massive accumulation of NK-like CD8 super(+) lymphocytes in the affected mucosa. We used these mice to demonstrate that blockade of IL-15 signaling with an antibody (TM- beta 1) that binds to murine IL-2/IL-15Rbeta (CD122) leads to a reversal of the autoimmune intestinal damage. The present study, along with work of others, provides the rationale to explore IL-15 blockade as a test of the hypothesis that uncontrolled expression of IL-15 is critical in the pathogenesis and maintenance of refractory CD. JF - Proceedings of the National Academy of Sciences, USA AU - Yokoyama, Seiji AU - Watanabe, Nobumasa AU - Sato, Noriko AU - Perera, Pin-Yu AU - Filkoski, Lyvouch AU - Tanaka, Toshiyuki AU - Miyasaka, Masayuki AU - Waldmann, Thomas A AU - Hiroi, Takachika AU - Perera, Liyanage P AD - Department of Allergy and Immunology, Tokyo Metropolitan Institute of Medical Science, Tokyo, 113-8613, Japan, pereral@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 15849 EP - 15854 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 37 SN - 0027-8424, 0027-8424 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - autoimmunity KW - celiac disease KW - immunotherapy KW - interleukine 15 receptor KW - Histocompatibility antigen HLA KW - Gluten KW - Interleukin 2 KW - Mucosa KW - Celiac disease KW - CD8 antigen KW - Lymphocytes KW - Transgenic mice KW - Antibodies KW - Cereals KW - Inflammatory diseases KW - Interleukin 15 KW - CD122 antigen KW - Intestine KW - Atrophy KW - Enterocytes KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - W 30935:Food Biotechnology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21217674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Antibody-mediated+blockade+of+IL-15+reverses+the+autoimmune+intestinal+damage+in+transgenic+mice+that+overexpress+IL-15+in+enterocytes&rft.au=Yokoyama%2C+Seiji%3BWatanabe%2C+Nobumasa%3BSato%2C+Noriko%3BPerera%2C+Pin-Yu%3BFilkoski%2C+Lyvouch%3BTanaka%2C+Toshiyuki%3BMiyasaka%2C+Masayuki%3BWaldmann%2C+Thomas+A%3BHiroi%2C+Takachika%3BPerera%2C+Liyanage+P&rft.aulast=Yokoyama&rft.aufirst=Seiji&rft.date=2009-01-01&rft.volume=106&rft.issue=37&rft.spage=15849&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0908834106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gluten; Histocompatibility antigen HLA; Interleukin 2; Celiac disease; Mucosa; Lymphocytes; CD8 antigen; Transgenic mice; Antibodies; Interleukin 15; Inflammatory diseases; Cereals; CD122 antigen; Intestine; Atrophy; Enterocytes; Signal transduction DO - http://dx.doi.org/10.1073/pnas.0908834106 ER - TY - JOUR T1 - Posttranslational interference of Ty1 retrotransposition by antisense RNAs AN - 21217644; 11260901 AB - Transposable elements impact genome function by altering gene expression and causing chromosome rearrangements. As a result, organisms have evolved mechanisms, such as RNA-interference, to minimize the level of transposition. However, organisms without the conserved RNAi pathways, like Saccharomyces cerevisiae, must use other mechanisms to prevent transposon movement. Here, we provide evidence that antisense (AS) RNAs from the retrovirus-like element Ty1 inhibit retrotransposition posttranslationally in Saccharomyces. Multiple Ty1AS transcripts overlap Ty1 sequences necessary for copy number control (CNC) and inhibit transposition in trans. Altering Ty1 copy number or deleting sequences in the CNC region that are required for reverse transcription affect Ty1AS RNA level and Ty1 movement. Ty1AS RNAs are enriched in virus-like particles, and are associated with a dramatic decrease in the level of integrase, less reverse transcriptase, and an inability to synthesize Ty1 cDNA. Thus, Ty1AS RNAs are part of an intrinsic mechanism that limits retrotransposition by reducing the level of proteins required for replication and integration. JF - Proceedings of the National Academy of Sciences, USA AU - Matsuda, Emiko AU - Garfinkel, David J AD - Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, garfinkd@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 15657 EP - 15662 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 37 SN - 0027-8424, 0027-8424 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Genomes KW - Virus-like particles KW - Replication KW - Antisense RNA KW - Transposition KW - Saccharomyces cerevisiae KW - copy number KW - Retrotransposition KW - Reverse transcription KW - Gene expression KW - Transposons KW - Integration KW - Copy number control KW - RNA KW - Chromosome rearrangements KW - RNA-mediated interference KW - RNA-directed DNA polymerase KW - Integrase KW - W 30940:Products KW - V 22320:Replication KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21217644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Posttranslational+interference+of+Ty1+retrotransposition+by+antisense+RNAs&rft.au=Matsuda%2C+Emiko%3BGarfinkel%2C+David+J&rft.aulast=Matsuda&rft.aufirst=Emiko&rft.date=2009-01-01&rft.volume=106&rft.issue=37&rft.spage=15657&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0908305106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Genomes; Virus-like particles; Replication; Antisense RNA; Transposition; Reverse transcription; Retrotransposition; copy number; Transposons; Gene expression; Integration; RNA; Copy number control; Chromosome rearrangements; RNA-directed DNA polymerase; RNA-mediated interference; Integrase; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1073/pnas.0908305106 ER - TY - JOUR T1 - Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppression AN - 21217633; 11260899 AB - Here, we show that recombinant Drosophila elp1 (D-elp1) produced in Sf9 cells or Escherichia coli, corresponding to the largest of the three subunits in the RNA polymerase II core elongator complex, has RNA-dependent RNA polymerase (RdRP) activity. D-elp1 is a noncanonical RdRP that can synthesize dsRNA from different ssRNA templates using either a primer-dependent or primer-independent initiation mechanism. Of the three core subunits, only D-elp1 depletion inhibits RNAi in S2 cells but does not affect micro RNA function. Furthermore, D-elp1 depletion results in increased steady state levels of representative transposon RNAs and a decrease in the corresponding transposon antisense transcripts and endo siRNAs. In contrast, although Dcr-2 depletion results in increased transposon RNA levels and a reduction in the corresponding endo siRNAs, there is no change in the transposon antisense RNA levels. In D-elp1 null third instar larvae transposon RNA levels are also increased and the corresponding transposon antisense RNAs are reduced. D-elp1 associates tightly with Dcr-2, similar to the Dicer-RdRP interaction observed in lower eukaryotes. These results identify an aspect of the RNAi pathway in Drosophila that suggest transposon derived endo siRNAs, critical for transposon suppression, are produced, in part, in a D-elp1 dependent step that converts transposon RNA into dsRNA that is subsequently processed by Dcr-2. The generality of this mechanism in genome defense and RNA silencing in higher eukaryotes is suggested. JF - Proceedings of the National Academy of Sciences, USA AU - Lipardi, Concetta AU - Paterson, Bruce M AD - Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 6118, 9000 Rockville Pike, Bethesda, MD 20892, patersob@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 15645 EP - 15650 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 37 SN - 0027-8424, 0027-8424 KW - Genetics Abstracts; Entomology Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Transposons KW - Genomes KW - DNA-directed RNA polymerase KW - siRNA KW - RNA-directed RNA polymerase KW - Double-stranded RNA KW - Antisense RNA KW - Escherichia coli KW - RNA-mediated interference KW - Drosophila KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering KW - Z 05360:Genetics and Evolution KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21217633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Identification+of+an+RNA-dependent+RNA+polymerase+in+Drosophila+involved+in+RNAi+and+transposon+suppression&rft.au=Lipardi%2C+Concetta%3BPaterson%2C+Bruce+M&rft.aulast=Lipardi&rft.aufirst=Concetta&rft.date=2009-01-01&rft.volume=106&rft.issue=37&rft.spage=15645&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0904984106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Genomes; Transposons; DNA-directed RNA polymerase; siRNA; Double-stranded RNA; RNA-directed RNA polymerase; Antisense RNA; RNA-mediated interference; Escherichia coli; Drosophila DO - http://dx.doi.org/10.1073/pnas.0904984106 ER - TY - JOUR T1 - Sexual reproduction in Aspergillus species of medical or economical importance: why so fastidious? AN - 21216050; 11186007 AB - Heterothallism is dependent upon the obligatory cross-mating between self-sterile homokaryotic individuals and represents a common pattern of sexuality in yeasts and molds. Heterothallic reproductive cycles have recently been discovered in three Aspergillus species of medical and economic importance, namely Aspergillus fumigatus,A. parasiticus and A. flavus. Together with Aspergillus udagawae (Neosartorya udagawae), heterothallism has now been discovered in a total of four aspergilli that affect human health or economy. These fungi appear to express relatively low levels of fertility compared to other heterothallic or homothallic aspergilli and require unusually fastidious environmental parameters to complete the sexual cycle. Because the purpose of sex is to reproduce, we favor the hypothesis that while fertility of these species is on the decline this is compensated by their proficiency to reproduce asexually in a wider range of environmental conditions. Heterothallism in these species could provide an invaluable tool for the recombinational analysis of factors relevant to pathogenicity or toxin production. There is concern, however, whether extensive recombinational analysis can be very practical in light of the fact that formation of ascospores in these species requires a long period of time and the construction of genetically marked strains is likely to decrease fertility even further. JF - Trends in Microbiology AU - Kwon-Chung, K J AU - Sugui, JA AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States, june_kwon-chung@nih.gov PY - 2009 SP - 481 EP - 487 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 17 IS - 11 SN - 0966-842X, 0966-842X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Fertility KW - Aspergillus flavus KW - Fungi KW - Sexual reproduction KW - Molds KW - Aspergillus KW - Toxins KW - Sexuality KW - Ascospores KW - Reproductive status KW - Pathogenicity KW - Reviews KW - Neosartorya KW - Environmental conditions KW - Economic importance KW - Heterothallism KW - Aspergillus parasiticus KW - Sex KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21216050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Microbiology&rft.atitle=Sexual+reproduction+in+Aspergillus+species+of+medical+or+economical+importance%3A+why+so+fastidious%3F&rft.au=Kwon-Chung%2C+K+J%3BSugui%2C+JA&rft.aulast=Kwon-Chung&rft.aufirst=K&rft.date=2009-01-01&rft.volume=17&rft.issue=11&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Trends+in+Microbiology&rft.issn=0966842X&rft_id=info:doi/10.1016%2Fj.tim.2009.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Fertility; Fungi; Molds; Sexual reproduction; Toxins; Reproductive status; Ascospores; Sexuality; Pathogenicity; Reviews; Economic importance; Environmental conditions; Heterothallism; Sex; Aspergillus flavus; Neosartorya; Aspergillus; Aspergillus parasiticus DO - http://dx.doi.org/10.1016/j.tim.2009.08.004 ER - TY - JOUR T1 - HIV-1 RNA Dimerization: It Takes Two to Tango AN - 21213297; 11149485 AB - Each viral particle of HIV-1, the infectious agent of AIDS, contains two copies of the full-length viral genomic RNA. Encapsldating two copies of genomic RNA is one of the characteristics of the retrovirus family. The two RNA molecules are both positive-sense and often identical; furthermore, each RNA encodes the full complement of genetic information required for viral replication. The two strands of RNA are intricately entwined within the core of the mature infectious virus as a ribonuclear complex with the viral proteins, including nucleocapsid. Multiple steps in the biogenesis of the genomic full-length RNA are involved in achieving this location and dimeric state. The viral sequences and proteins involved in the process of RNA dimerization, both for the initial interstrand contact and subsequent steps that result in the condensed, stable conformation of the genomic RNA, are outlined in this review. In addition, the impact of the dimeric state of HIV-1 viral RNA is discussed with respect to its importance in efficient viral replication and, consequently, the potential development of antiviral strategies designed to disrupt the formation of dimeric RNA. JF - AIDS Reviews AU - Moore, MD AU - Hu, W-S AD - HIV Drug Resistance Program, National Cancer Institute, Frederick, MD, USA, whu@ncifcrf.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 91 EP - 102 VL - 11 IS - 2 SN - 1139-6121, 1139-6121 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Retrovirus KW - RNA KW - Replication KW - Human immunodeficiency virus 1 KW - Nucleocapsids KW - genomics KW - Conformation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21213297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Reviews&rft.atitle=HIV-1+RNA+Dimerization%3A+It+Takes+Two+to+Tango&rft.au=Moore%2C+MD%3BHu%2C+W-S&rft.aulast=Moore&rft.aufirst=MD&rft.date=2009-01-01&rft.volume=11&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=AIDS+Reviews&rft.issn=11396121&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Retrovirus; RNA; Replication; Nucleocapsids; genomics; Conformation; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Safety and Immunogenicity of Multiple and Higher Doses of an Inactivated Influenza A/H5N1 Vaccine AN - 21210075; 11189460 AB - Background. H5N1 avian influenza represents an episodic zoonotic disease with the potential to cause a pandemic, and antiviral resistance is of considerable concern. We sought to generate high-titer H5N1 antibodies in healthy volunteers for the purpose of developing hyperimmune intravenous immunoglobulin. Methods. We conducted a dose-escalating, unblinded clinical trial involving 75 subjects aged 18-59 years. Three cohorts of twenty-five subjects were enrolled sequentially and received 90, 120, or 180 [mu]g of H5N1 A/Vietnam/1203/04 vaccine in 4 doses administered [image]28 days apart. Results. No statistically significant dose-related increases in the geometric mean titers (GMTs) of serum hemagglutination inhibition antibody were observed when the 90-[mu]g, 120-[mu]g, and 180-[mu]g cohorts were compared. When the cohorts were analyzed together to determine the effect of additional vaccinations, the GMTs of hemagglutination inhibition antibody after the first, second, third, and fourth vaccinations were 1:15.7, 1:22.2, 1:36.0, and 1:32.0, respectively (first vaccination vs. baseline, [image] ; second vs. first vaccination, [image] ; and third vs. second vaccination, [image]). The microneutralization GMTs after the first, second, third, and fourth vaccinations were 1:17.5, 1:33.1, 1:55.7, and 1:68.4, respectively ([image] for all comparisons). Conclusion. The results of our study suggest that a third and fourth dose of the H5N1 A/Vietnam/1203/04 vaccine may result in higher hemagglutination inhibition and microneutralization GMTs, compared with the GMTs resulting from fewer doses. There was no benefit to increasing the dose of the vaccine. Trial registration. Clinical Trials.gov identifier: JF - Journal of Infectious Diseases AU - Beigel, John H AU - Voell, Jocelyn AU - Huang, Chiung-Yu AU - Burbelo, Peter D AU - Lane, HClifford AD - National Institute of Allergy and Infectious Diseases and National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, jbeigel@niaid.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 501 EP - 508 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 4 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - vaccines KW - Intravenous administration KW - Hemagglutination inhibition KW - Influenza A KW - immunogenicity KW - Statistical analysis KW - clinical trials KW - Vaccination KW - Clinical trials KW - Vietnam KW - influenza KW - Fowl plague KW - pandemics KW - Immunogenicity KW - Vaccines KW - Immunoglobulins KW - A 01340:Antibiotics & Antimicrobials KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21210075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Safety+and+Immunogenicity+of+Multiple+and+Higher+Doses+of+an+Inactivated+Influenza+A%2FH5N1+Vaccine&rft.au=Beigel%2C+John+H%3BVoell%2C+Jocelyn%3BHuang%2C+Chiung-Yu%3BBurbelo%2C+Peter+D%3BLane%2C+HClifford&rft.aulast=Beigel&rft.aufirst=John&rft.date=2009-01-01&rft.volume=200&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Fowl plague; pandemics; Intravenous administration; Immunogenicity; Influenza A; Hemagglutination inhibition; Statistical analysis; Vaccines; Clinical trials; Vaccination; Immunoglobulins; vaccines; immunogenicity; clinical trials; influenza; Vietnam ER - TY - JOUR T1 - A Cluster of Cases of Nosocomial Legionnaires Disease Linked to a Contaminated Hospital Decorative Water Fountain AN - 21209209; 11189151 AB - Background. Nosocomial outbreaks of Legionnaires disease have been linked to contaminated water in hospitals. Immunocompromised patients are particularly vulnerable and, when infected, have a high mortality rate. We report the investigation of a cluster of cases of nosocomial pneumonia attributable to Legionella pneumophila serogroup 1 that occurred among patients on our stem cell transplantation unit. Methods. We conducted a record review to identify common points of potential exposure, followed by environmental and water sampling for Legionella species from those sources. We used an air sampler to in an attempt to detect aerosolized Legionella and pulsed-field gel electrophoresis to compare clinical and environmental isolates. Results. The most likely sources identified were the water supply in the patients' rooms and a decorative fountain in the radiation oncology suite. Samples from the patients' rooms did not grow Legionella species. Cultures of the fountain, which had been restarted 4 months earlier after being shut off for 5 months, yielded L. pneumophila serogroup 1. The isolates from both patients and the fountain were identical by pulsed-field gel electrophoresis. Both patients developed pneumonia within 10 days of completing radiation therapy, and each reported having observed the fountain at close range. Both patients' infections were identified early and treated promptly, and both recovered. Conclusions. This cluster was caused by contamination of a decorative fountain despite its being equipped with a filter and ozone generator. Fountains are a potential source of nosocomial Legionnaires disease despite standard maintenance and sanitizing measures. In our opinion, fountains present unacceptable risk in hospitals serving immunocompromised patients. JF - Infection Control and Hospital Epidemiology AU - Palmore, Tara N AU - Stock, Frida AU - White, Margaret AU - Bordner, MaryAnn AU - Michelin, Angela AU - Bennett, John E AU - Murray, Patrick R AU - Henderson, David K AD - Warren Grant Magnusen Clinical Center and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., tpalmore@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 764 EP - 768 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 30 IS - 8 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Health & Safety Science Abstracts KW - Contamination KW - Cell culture KW - Oncology KW - Water supplies KW - Radiation KW - Air sampling KW - Vulnerability KW - Ozone KW - outbreaks KW - Immunocompromised hosts KW - vulnerability KW - Pneumonia KW - Hospitals KW - Legionella pneumophila KW - Water sampling KW - Infection KW - infection KW - water pollution KW - Radiation therapy KW - Mortality KW - Electrophoresis KW - stem cell transplantation KW - Samplers KW - Maintenance KW - Legionnaire's disease KW - Water pollution KW - Filters KW - Reviews KW - Pulsed-field gel electrophoresis KW - Outbreaks KW - J 02420:Plant Diseases KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21209209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=A+Cluster+of+Cases+of+Nosocomial+Legionnaires+Disease+Linked+to+a+Contaminated+Hospital+Decorative+Water+Fountain&rft.au=Palmore%2C+Tara+N%3BStock%2C+Frida%3BWhite%2C+Margaret%3BBordner%2C+MaryAnn%3BMichelin%2C+Angela%3BBennett%2C+John+E%3BMurray%2C+Patrick+R%3BHenderson%2C+David+K&rft.aulast=Palmore&rft.aufirst=Tara&rft.date=2009-01-01&rft.volume=30&rft.issue=8&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F598855 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Water sampling; Contamination; stem cell transplantation; Oncology; Cell culture; Infection; Samplers; Water supplies; Filters; Radiation; Immunocompromised hosts; Pulsed-field gel electrophoresis; Pneumonia; Ozone; Hospitals; Radiation therapy; Electrophoresis; outbreaks; Water pollution; Legionnaire's disease; Maintenance; Reviews; Air sampling; infection; vulnerability; Vulnerability; Outbreaks; water pollution; Legionella pneumophila DO - http://dx.doi.org/10.1086/598855 ER - TY - JOUR T1 - A Point Mutation in the agr Locus rather than Expression of the Panton-Valentine Leukocidin Caused Previously Reported Phenotypes in Staphylococcus aureus Pneumonia and Gene Regulation AN - 21206065; 11189485 AB - sThe role of Panton-Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S. aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by earlier investigators. In agreement with other studies that failed to detect similar effects of PVL using community-associated methicillin-resistant S. aureus strains, we found no significant effect of PVL on gene expression or pathogenesis after we repaired the mutation. These findings provide further evidence that PVL does not have a major impact on S. aureus pathogenesis. Moreover, our results demonstrate that a single nucleotide polymorphism in an intergenic region can dramatically affect bacterial physiology and virulence. Finally, our work emphasizes the need to frequently evaluate the integrity of the S. aureus agr locus. JF - Journal of Infectious Diseases AU - Villaruz, Amer E AU - Wardenburg, Juliane Bubeck AU - Khan, Burhan A AU - Whitney, Adeline R AU - Sturdevant, Daniel E AU - Gardner, Donald J AU - DeLeo, Frank R AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, motto@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 724 EP - 734 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 200 IS - 5 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Promoters KW - leukocidin KW - Single-nucleotide polymorphism KW - Gene regulation KW - Drug resistance KW - Point mutation KW - Staphylococcus aureus KW - Pneumonia KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - N 14845:Miscellaneous KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21206065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=A+Point+Mutation+in+the+agr+Locus+rather+than+Expression+of+the+Panton-Valentine+Leukocidin+Caused+Previously+Reported+Phenotypes+in+Staphylococcus+aureus+Pneumonia+and+Gene+Regulation&rft.au=Villaruz%2C+Amer+E%3BWardenburg%2C+Juliane+Bubeck%3BKhan%2C+Burhan+A%3BWhitney%2C+Adeline+R%3BSturdevant%2C+Daniel+E%3BGardner%2C+Donald+J%3BDeLeo%2C+Frank+R%3BOtto%2C+Michael&rft.aulast=Villaruz&rft.aufirst=Amer&rft.date=2009-01-01&rft.volume=200&rft.issue=5&rft.spage=724&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F604728 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Virulence; Promoters; leukocidin; Single-nucleotide polymorphism; Drug resistance; Gene regulation; Point mutation; Pneumonia; Staphylococcus aureus DO - http://dx.doi.org/10.1086/604728 ER - TY - JOUR T1 - Structure of ERA in complex with the 3' end of 16S rRNA: Implications for ribosome biogenesis AN - 21079084; 11260835 AB - ERA, composed of an N-terminal GTPase domain followed by an RNA-binding KH domain, is essential for bacterial cell viability. It binds to 16S rRNA and the 30S ribosomal subunit. However, its RNA-binding site, the functional relationship between the two domains, and its role in ribosome biogenesis remain unclear. We have determined two crystal structures of ERA, a binary complex with GDP and a ternary complex with a GTP-analog and the sub(1531)AUCACCUCCUUA sub(1542) sequence at the 3' end of 16S rRNA. In the ternary complex, the first nine of the 12 nucleotides are recognized by the protein. We show that GTP binding is a prerequisite for RNA recognition by ERA and that RNA recognition stimulates its GTP-hydrolyzing activity. Based on these and other data, we propose a functional cycle of ERA, suggesting that the protein serves as a chaperone for processing and maturation of 16S rRNA and a checkpoint for assembly of the 30S ribosomal subunit. The AUCA sequence is highly conserved among bacteria, archaea, and eukaryotes, whereas the CCUCC, known as the anti-Shine- Dalgarno sequence, is conserved in noneukaryotes only. Therefore, these data suggest a common mechanism for a highly conserved ERA function in all three kingdoms of life by recognizing the AUCA, with a `twist- for noneukaryotic ERA proteins by also recognizing the CCUCC. JF - Proceedings of the National Academy of Sciences, USA AU - Tu, Chao AU - Zhou, Xiaomei AU - Tropea, Joseph E AU - Austin, Brian P AU - Waugh, David S AU - Court, Donald L AU - Ji, Xinhua AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, jix@ncifcrf.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 14843 EP - 14848 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 35 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids KW - GTPase KW - KH domain KW - 30S ribosomal subunit KW - Data processing KW - Archaea KW - GTP KW - Ribosomal subunits KW - Ribosomes KW - Era protein KW - Nucleotides KW - GDP KW - Crystal structure KW - Conserved sequence KW - Chaperones KW - rRNA 16S KW - Guanosinetriphosphatase KW - J 02330:Biochemistry KW - A 01490:Miscellaneous KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21079084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Structure+of+ERA+in+complex+with+the+3%27+end+of+16S+rRNA%3A+Implications+for+ribosome+biogenesis&rft.au=Tu%2C+Chao%3BZhou%2C+Xiaomei%3BTropea%2C+Joseph+E%3BAustin%2C+Brian+P%3BWaugh%2C+David+S%3BCourt%2C+Donald+L%3BJi%2C+Xinhua&rft.aulast=Tu&rft.aufirst=Chao&rft.date=2009-01-01&rft.volume=106&rft.issue=35&rft.spage=14843&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0904032106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; GDP; Crystal structure; GTP; Conserved sequence; Chaperones; Ribosomes; Ribosomal subunits; Era protein; rRNA 16S; Nucleotides; Guanosinetriphosphatase; Archaea DO - http://dx.doi.org/10.1073/pnas.0904032106 ER - TY - JOUR T1 - Interleukin-2 cycling causes transient increases in high-sensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels AN - 21077976; 11087108 AB - Objective: To determine the effects of interleukin (IL)-2 treatment on inflammatory and thrombotic biomarkers in chronically HIV-infected adults receiving antiretroviral therapy. Methods: Cryopreserved plasma was evaluated retrospectively for C-reactive protein (CRP) and D-dimer at baseline, end of an IL-2 cycle, and long-term follow up from two randomized, controlled trials: 57 IL-2-naive adults receiving either three to six cycles of IL-2 as well as antiretroviral therapy (nucleoside analogues) or antiretroviral therapy alone for 12 months, and 40 IL-2-experienced adults on highly active antiretroviral therapy who either interrupted or continued therapy for 6 months after a baseline IL-2 cycle. High-sensitivity CRP (hsCRP) was measured by immunonephelometry (detection limit 0.175 mg/l) and D-dimer by latex agglutination (detection limit0.20 mg/l). Median within-group differences and pre and post-IL-2 changes between groups were assessed via nonparametric Wilcoxon signed-rank and Mann-Whitney U-tests. Spearman's rank test was used to assess correlations between changes in hsCRP, D-dimer, and HIV-RNA viral load. Results: Significant increases in hsCRP (study 1: 138.6 mg/l; study 2: 58.9 mg/l) and D-dimer (study 1:3.1 mg/l; study 2: 0.4 mg/l, all P < 0.0001) occurred by the end of the initial IL-2 cycle, returning to baseline by the end of study. No correlations were seen between changes in hsCRP or D-dimer and HIV-RNA, CD4 T-cell count, or proliferation (Ki67 expression). No thrombotic or cardiovascular serious adverse events occurred during these study periods. Conclusion: IL-2 dosing caused transient increases in plasma hsCRP and D-dimer levels, regardless of HIV-RNA viral load, suggesting the possibility of increased risk for thrombotic events. JF - AIDS AU - Porter, BO AU - Shen, J AU - Kovacs, JA AU - Davey, R T AU - Rehm, C AU - Lozier, J AU - Csako, G AU - Nghiem, K AU - Costello, R AU - Lane, H C AU - Sereti, I AD - National Institutes of Health, Building 10, Clinical Center, Room 11B07A, 10 Center Drive, Bethesda, MD 20892, USA, isereti@niaid.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 2015 EP - 2019 VL - 23 IS - 15 SN - 0269-9370, 0269-9370 KW - HIV KW - Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts; Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Bioindicators KW - Acquired immune deficiency syndrome KW - Interleukin 2 KW - Latex agglutination KW - clinical trials KW - Antiretroviral agents KW - Clinical trials KW - biomarkers KW - Cryopreservation KW - Inflammation KW - nucleoside analogs KW - CD4 antigen KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - antiretroviral agents KW - Lymphocytes T KW - Proteins KW - Side effects KW - C-reactive protein KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21077976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Interleukin-2+cycling+causes+transient+increases+in+high-sensitivity+C-reactive+protein+and+D-dimer+that+are+not+associated+with+plasma+HIV-RNA+levels&rft.au=Porter%2C+BO%3BShen%2C+J%3BKovacs%2C+JA%3BDavey%2C+R+T%3BRehm%2C+C%3BLozier%2C+J%3BCsako%2C+G%3BNghiem%2C+K%3BCostello%2C+R%3BLane%2C+H+C%3BSereti%2C+I&rft.aulast=Porter&rft.aufirst=BO&rft.date=2009-01-01&rft.volume=23&rft.issue=15&rft.spage=2015&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988004-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - nucleoside analogs; CD4 antigen; Interleukin 2; highly active antiretroviral therapy; Latex agglutination; Lymphocytes T; Cryopreservation; biomarkers; Inflammation; C-reactive protein; Bioindicators; Acquired immune deficiency syndrome; antiretroviral agents; Proteins; clinical trials; Clinical trials; Antiretroviral agents; Side effects; Human immunodeficiency virus DO - http://dx.doi.org/10.1097/QAD.0b013e32832d72c6 ER - TY - JOUR T1 - A Novel Combination of Factors, Termed SPIE, which Promotes Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells AN - 21066878; 10989799 AB - Background Stromal-Derived Inducing Activity (SDIA) is one of the most efficient methods of generating dopaminergic (DA) neurons from embryonic stem cells (ESC). DA neuron induction can be achieved by co-culturing ESC with the mouse stromal cell lines PA6 or MS5. The molecular nature of this effect, which has been termed aSDIAa is so far unknown. Recently, we found that factors secreted by PA6 cells provided lineage-specific instructions to induce DA differentiation of human ESC (hESC). Methodology/Principal Findings In the present study, we compared PA6 cells to various cell lines lacking the SDIA effect, and employed genome expression analysis to identify differentially-expressed signaling molecules. Among the factors highly expressed by PA6 cells, and known to be associated with CNS development, were stromal cell-derived factor 1 (SDF-1/CXCL12), pleiotrophin (PTN), insulin-like growth factor 2 (IGF2), and ephrin B1 (EFNB1). When these four factors, the combination of which was termed SPIE, were applied to hESC, they induced differentiation to TH-positive neurons in vitro. RT-PCR and western blot analysis confirmed the expression of midbrain specific markers, including engrailed 1, Nurr1, Pitx3, and dopamine transporter (DAT) in cultures influenced by these four molecules. Electrophysiological recordings showed that treatment of hESC with SPIE induced differentiation of neurons that were capable of generating action potentials and forming functional synaptic connections. Conclusions/Significance The combination of SDF-1, PTN, IGF2, and EFNB1 mimics the DA phenotype-inducing property of SDIA and was sufficient to promote differentiation of hESC to functional midbrain DA neurons. These findings provide a method for differentiating hESC to form DA neurons, without a requirement for the use of animal-derived cell lines or products. JF - PLoS ONE AU - Vazin, Tandis AU - Becker, Kevin G AU - Chen, Jia AU - Spivak, Charles E AU - Lupica, Carl R AU - Zhang, Yongqing AU - Worden, Lila AU - Freed, William J AU - Hashimoto, Kenji AD - Cellular Neurobiology Research Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Baltimore, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 4 IS - 8 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - SDF-1 protein KW - Central nervous system KW - stromal cells KW - Cell culture KW - ephrins KW - Differentiation KW - Mesencephalon KW - Action potential KW - Dopamine transporter KW - Stem cells KW - Neurogenesis KW - Embryo cells KW - Polymerase chain reaction KW - Insulin-like growth factor II KW - Western blotting KW - Synapses KW - Nuclear receptors KW - pleiotrophin KW - Nurr1 protein KW - Electrophysiological recording KW - Neurons KW - Insulin-like growth factors KW - CXCL12 protein KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21066878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=A+Novel+Combination+of+Factors%2C+Termed+SPIE%2C+which+Promotes+Dopaminergic+Neuron+Differentiation+from+Human+Embryonic+Stem+Cells&rft.au=Vazin%2C+Tandis%3BBecker%2C+Kevin+G%3BChen%2C+Jia%3BSpivak%2C+Charles+E%3BLupica%2C+Carl+R%3BZhang%2C+Yongqing%3BWorden%2C+Lila%3BFreed%2C+William+J%3BHashimoto%2C+Kenji&rft.aulast=Vazin&rft.aufirst=Tandis&rft.date=2009-01-01&rft.volume=4&rft.issue=8&rft.spage=e6606&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0006606 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Central nervous system; SDF-1 protein; stromal cells; ephrins; Cell culture; Mesencephalon; Differentiation; Neurogenesis; Stem cells; Dopamine transporter; Action potential; Embryo cells; Polymerase chain reaction; Insulin-like growth factor II; Western blotting; Synapses; Nuclear receptors; pleiotrophin; Electrophysiological recording; Nurr1 protein; Neurons; Insulin-like growth factors; CXCL12 protein; Signal transduction DO - http://dx.doi.org/10.1371/journal.pone.0006606 ER - TY - JOUR T1 - Human embryonic stem cells which express hrGFP in the undifferentiated state and during dopaminergic differentiation AN - 20834079; 11011945 AB - Purpose: human embryonic stem cells (hESCs) which express a reporter gene consistently during all phases of differentiation would be valuable for basic research on cell transplantation. In this study, we describe karyotypically-abnormal variant hESCs, BGO1V2-EFG, which express hrGFP driven by the EF1 promoter.Methods: BGO1V2-EFG cells were analyzed by using immunocytochemistry, single cell-based confocal image, and in vitro differentiation, including dopaminergic differentiation.Results: Undifferentiated BGO1V2-EFG cells expressed pluripotent ESC markers and retained the ability to differentiate into cell types of all three germ layers. BGO1V2-EFG cells maintained stable and robust hrGFP expression in vitro in the undifferentiated state and during differentiation. The EF1 promoter retained activity during dopaminergic differentiation, as 76% of tyrosine hydroxlase (TH)-positive cells co-expressed hrGFP by confocal analysis. Treated with sodium butyrate (0.02 mM to 2.0 mM), an inhibitor of histone deacetylase (HDAC), during differentiation did not affect hrGFP expression, although TH expression was reduced by higher concentrations of sodium butyrate.Conclusion: BGO1V2-EFG cells maintain stable and robust hrGFP expression in the undifferentiated state and during neural differentiation. Especially, the EF1 promoter was effective in driving hrGFP expression during dopaminergic differentiation. BGO1V2-EFG cells may be useful for transplantation studies in Parkinson disease animal models. JF - Restorative Neurology and Neuroscience AU - Chen, Jia AU - Tsai, Shang-Yi AU - Vazin, Tandis AU - Coggiano, Mark AU - Freed, William J AD - Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 359 EP - 370 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG The Netherlands VL - 27 IS - 4 SN - 0922-6028, 0922-6028 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; CSA Neurosciences Abstracts KW - Immunocytochemistry KW - Histone deacetylase KW - Transplantation KW - Parkinson's disease KW - Animal models KW - Tyrosine KW - Neurodegenerative diseases KW - Promoters KW - Differentiation KW - Nervous system KW - Stem cells KW - Movement disorders KW - Dopamine KW - Embryo cells KW - Reporter gene KW - Sodium butyrate KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20834079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Restorative+Neurology+and+Neuroscience&rft.atitle=Human+embryonic+stem+cells+which+express+hrGFP+in+the+undifferentiated+state+and+during+dopaminergic+differentiation&rft.au=Chen%2C+Jia%3BTsai%2C+Shang-Yi%3BVazin%2C+Tandis%3BCoggiano%2C+Mark%3BFreed%2C+William+J&rft.aulast=Chen&rft.aufirst=Jia&rft.date=2009-01-01&rft.volume=27&rft.issue=4&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Restorative+Neurology+and+Neuroscience&rft.issn=09226028&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Immunocytochemistry; Transplantation; Parkinson's disease; Animal models; Tyrosine; Differentiation; Promoters; Neurodegenerative diseases; Stem cells; Nervous system; Dopamine; Movement disorders; Embryo cells; Reporter gene; Sodium butyrate ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 20824604; 11012195 AB - In addition to maintaining the GenBank+ nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubChem suite of small molecule databases. Augmenting many of the web applications is custom implementation of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. JF - Nucleic Acids Research AU - Sayers, Eric W AU - Barrett, Tanya AU - Benson, Dennis A AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Edgar, Ron AU - Federhen, Scott AU - Feolo, Michael AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Landsman, David AU - Lipman, David J AU - Madden, Thomas L AU - Maglott, Donna R AU - Miller, Vadim AU - Mizrachi, Ilene AU - Ostell, James AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Sequeira, Edwin AU - Sherry, Stephen T AU - Shumway, Martin AU - Sirotkin, Karl AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Yaschenko, Eugene AU - Ye, Jian Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - D5 EP - D15 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 37 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - Genotyping KW - DNA probes KW - Cancer KW - Gene expression KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Taxonomy KW - Protein interaction KW - V 22360:AIDS and HIV KW - G 07740:Evolution KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20824604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Sayers%2C+Eric+W%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BEdgar%2C+Ron%3BFederhen%2C+Scott%3BFeolo%2C+Michael%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BLandsman%2C+David%3BLipman%2C+David+J%3BMadden%2C+Thomas+L%3BMaglott%2C+Donna+R%3BMiller%2C+Vadim%3BMizrachi%2C+Ilene%3BOstell%2C+James%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BSequeira%2C+Edwin%3BSherry%2C+Stephen+T%3BShumway%2C+Martin%3BSirotkin%2C+Karl%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BYaschenko%2C+Eugene%3BYe%2C+Jian&rft.aulast=Sayers&rft.aufirst=Eric&rft.date=2009-01-01&rft.volume=37&rft.issue=suppl_1&rft.spage=D5&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn741 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; DNA probes; Genotyping; Cancer; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Polymerase chain reaction; Taxonomy; Protein interaction; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1093/nar/gkn741 ER - TY - JOUR T1 - Kinetic gating of the proton pump in cytochrome c oxidase AN - 20806210; 10917391 AB - Cytochrome c oxidase (CcO), the terminal enzyme of the respiratory chain, reduces oxygen to water and uses the released energy to pump protons across a membrane. Here, we use kinetic master equations to explore the energetic and kinetic control of proton pumping in CcO. We construct models consistent with thermodynamic principles, the structure of CcO, experimentally known proton affinities, and equilibrium constants of intermediate reactions. The resulting models are found to capture key properties of CcO, including the midpoint redox potentials of the metal centers and the electron transfer rates. We find that coarse- grained models with two proton sites and one electron site can pump one proton per electron against membrane potentials exceeding 100 mV. The high pumping efficiency of these models requires strong electrostatic couplings between the proton loading (pump) site and the electron site (heme a), and kinetic gating of the internal proton transfer. Gating is achieved by enhancing the rate of proton transfer from the conserved Glu-242 to the pump site on reduction of heme a, consistent with the predictions of the water- gated model of proton pumping. The model also accounts for the phenotype of D-channel mutations associated with loss of pumping but retained turnover. The fundamental mechanism identified here for the efficient conversion of chemical energy into an electrochemical potential should prove relevant also for other molecular machines and novel fuel-cell designs. JF - Proceedings of the National Academy of Sciences, USA AU - Kim, Young C AU - Wikstrm, M¥rten AU - Hummer, Gerhard AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, gerhard.hummer@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 13707 EP - 13712 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 33 SN - 0027-8424, 0027-8424 KW - Sustainability Science Abstracts KW - bioenergetics KW - biological machines KW - kinetic master equation KW - respiration KW - Metals KW - Membranes KW - Thermodynamics KW - Enzymes KW - redox potential KW - Oxygen KW - Efficiency KW - Cytochrome KW - Kinetics KW - Pumps KW - Electrochemistry KW - Mutation KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20806210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Kinetic+gating+of+the+proton+pump+in+cytochrome+c+oxidase&rft.au=Kim%2C+Young+C%3BWikstrm%2C+M%C2%A5rten%3BHummer%2C+Gerhard&rft.aulast=Kim&rft.aufirst=Young&rft.date=2009-01-01&rft.volume=106&rft.issue=33&rft.spage=13707&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0903938106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Oxygen; Metals; Efficiency; Membranes; Cytochrome; Thermodynamics; Kinetics; Enzymes; Pumps; redox potential; Electrochemistry; Mutation DO - http://dx.doi.org/10.1073/pnas.0903938106 ER - TY - JOUR T1 - Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding AN - 20805946; 10917356 AB - This study describes the isolation and characterization of a neutralizing monoclonal antibody (mAb) against anthrax edema factor, EF13D. EF13D neutralized edema toxin (ET)-mediated cyclic AMP (cAMP) responses in cells and protected mice from both ET-induced footpad edema and systemic ET-mediated lethality. The antibody epitope was mapped to domain IV of EF. The mAb was able to compete with calmodulin (CaM) for EF binding and displaced CaM from EF-CaM complexes. EF-mAb binding affinity (0.05-0.12 nM) was 50- to 130-fold higher than that reported for EF-CaM. This anti-EF neutralizing mAb could potentially be used alone or with an anti-PA mAb in the emergency prophylaxis and treatment of anthrax infection. JF - Proceedings of the National Academy of Sciences, USA AU - Chen, Zhaochun AU - Moayeri, Mahtab AU - Zhao, Huaying AU - Crown, Devorah AU - Leppla, Stephen H AU - Purcell, Robert H Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 13487 EP - 13492 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 32 SN - 0027-8424, 0027-8424 KW - Toxicology Abstracts; Calcium & Calcified Tissue Abstracts KW - Lethality KW - Monoclonal antibodies KW - Cyclic AMP KW - Prophylaxis KW - Edema KW - Anthrax KW - Calmodulin KW - Infection KW - Toxins KW - Calcium-binding protein KW - Epitopes KW - T 2000:Cellular Calcium KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20805946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Potent+neutralization+of+anthrax+edema+toxin+by+a+humanized+monoclonal+antibody+that+competes+with+calmodulin+for+edema+factor+binding&rft.au=Chen%2C+Zhaochun%3BMoayeri%2C+Mahtab%3BZhao%2C+Huaying%3BCrown%2C+Devorah%3BLeppla%2C+Stephen+H%3BPurcell%2C+Robert+H&rft.aulast=Chen&rft.aufirst=Zhaochun&rft.date=2009-01-01&rft.volume=106&rft.issue=32&rft.spage=13487&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0906581106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Lethality; Monoclonal antibodies; Cyclic AMP; Prophylaxis; Calmodulin; Anthrax; Edema; Infection; Epitopes; Calcium-binding protein; Toxins DO - http://dx.doi.org/10.1073/pnas.0906581106 ER - TY - JOUR T1 - High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis AN - 20804463; 10917364 AB - A long-standing question in retrovirus biology is how RNA genomes are distributed among virions. In the studies presented in this report, we addressed this issue by directly examining HIV-1 RNAs in virions using a modified HIV-1 genome that contained recognition sites for BglG, an antitermination protein in the Escherichia coli bgl operon, which was coexpressed with a fragment of BglG RNA binding protein fused to a fluorescent protein. Our results demonstrate that the majority of virions (>90%) contain viral RNAs. We also coexpressed HIV-1 genomes containing binding sites for BglG or the bacteriophage MS2 coat protein along with 2 fluorescent protein-tagged RNA binding proteins. This method allows simultaneously labeling and discrimination of 2 different RNAs at single-RNA-detection sensitivity. Using this strategy, we obtained physical evidence that virions contain RNAs derived from different parental viruses (heterozygous virion) at ratios expected from a random distribution, and we found that this ratio can be altered by changing the dimerization sequences. Our studies of heterozygous virions also support a generally accepted but unproven assumption that most particles contain 1 dimer. This study provides answers to long-standing questions in HIV-1 biology and illustrates the power and sensitivity of the 2-RNA labeling method, which can also be adapted to analyze various issues of RNA biogenesis including the detection of different RNAs in live cell imaging. JF - Proceedings of the National Academy of Sciences, USA AU - Chen, Jianbo AU - Nikolaitchik, Olga AU - Singh, Jatinder AU - Wright, Andrew AU - Bencsics, Craig E AU - Coffin, John M AU - Ni, Na AU - Lockett, Stephen AU - Pathak, Vinay K AU - Hu, Wei-Shau AD - HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, whu@ncifcrf.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 13535 EP - 13540 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 106 IS - 32 SN - 0027-8424, 0027-8424 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Coat protein KW - Computed tomography KW - Genomes KW - Heterozygotes KW - Operons KW - Packaging KW - Phages KW - RNA KW - RNA-binding protein KW - Retrovirus KW - Virions KW - genomics KW - Human immunodeficiency virus 1 KW - Escherichia coli KW - V 22360:AIDS and HIV KW - J 02430:Symbiosis, Antibiosis & Phages KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20804463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=High+efficiency+of+HIV-1+genomic+RNA+packaging+and+heterozygote+formation+revealed+by+single+virion+analysis&rft.au=Chen%2C+Jianbo%3BNikolaitchik%2C+Olga%3BSingh%2C+Jatinder%3BWright%2C+Andrew%3BBencsics%2C+Craig+E%3BCoffin%2C+John+M%3BNi%2C+Na%3BLockett%2C+Stephen%3BPathak%2C+Vinay+K%3BHu%2C+Wei-Shau&rft.aulast=Chen&rft.aufirst=Jianbo&rft.date=2009-01-01&rft.volume=106&rft.issue=32&rft.spage=13535&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0906822106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Phages; Genomes; Virions; Retrovirus; RNA-binding protein; RNA; Computed tomography; Heterozygotes; Coat protein; genomics; Operons; Packaging; Human immunodeficiency virus 1; Escherichia coli DO - http://dx.doi.org/10.1073/pnas.0906822106 ER - TY - JOUR T1 - Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy? AN - 20797375; 10885500 AB - Introduction Experimental streptococcal cell wall (SCW)-induced arthritis is characterized by two successive phases of the disease. The acute phase occurs early and is associated with an inflammatory process and neutrophil infiltration into the synovium. The second chronic phase is related to effector T-cell activation and the dysregulation of macrophage function. Creation of an immunomodulatory environment has been attributed to apoptotic cells themselves, apoptotic cell uptake by phagocytes as well as a less sensibility of phagocytes capturing apoptotic bodies to activation. Therefore we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats. Methods Rat apoptotic thymocytes were injected intraperitoneally (2 x 10 super(8)) in addition to an arthritogenic dose of systemic SCW in LEW female rats. Control rats received SCW immunization and PBS. Rats were then followed for arthritis occurrence and circulating cytokine detection. At sacrifice, regulatory T cells (Tregs) and macrophages were analyzed. Results Apoptotic cell injection profoundly suppressed joint swelling and destruction typically observed during the acute and chronic phases of SCW-induced arthritis. Synovial inflammatory cell infiltration and bone destruction were also markedly suppressed. Ex vivo experiments revealed reduced levels of TNF in cultures of macrophages from rats challenged with SCW in the presence of apoptotic thymocytes as well as reduced macrophage response to lipopolysaccharide. Moreover, apoptotic cell injection induced higher Foxp3+ Tregs in the lymphoid organs, especially in the draining lymph nodes. Conclusions Our data indicate that apoptotic cells modulate macrophage function and result in Treg generation/increase. This may be involved in inhibition of inflammation and amelioration of arthritis. This highlights and confirms previous studies showing that in vivo generation of Tregs using apoptotic cell injection may be a useful tool to prevent and treat inflammatory autoimmune responses. JF - Arthritis Research & Therapy AU - Perruche, S AU - Saas, P AU - Chen, W AD - Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1 VL - 11 IS - 4 SN - 1478-6354, 1478-6354 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Immunoregulation KW - Apoptosis KW - Synovium KW - Tumor necrosis factor KW - Joint diseases KW - Cell culture KW - Immunomodulation KW - Cell activation KW - Phagocytes KW - Foxp3 protein KW - Arthritis KW - Lymphocytes T KW - Cytokines KW - Lipopolysaccharides KW - Streptococcus KW - Data processing KW - Leukocytes (neutrophilic) KW - Immunization KW - Lymph nodes KW - Inflammation KW - Bone loss KW - Thymocytes KW - Cell walls KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20797375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=Apoptotic+cell-mediated+suppression+of+streptococcal+cell+wall-induced+arthritis+is+associated+with+alteration+of+macrophage+function+and+local+regulatory+T-cell+increase%3A+a+potential+cell-based+therapy%3F&rft.au=Perruche%2C+S%3BSaas%2C+P%3BChen%2C+W&rft.aulast=Perruche&rft.aufirst=S&rft.date=2009-01-01&rft.volume=11&rft.issue=4&rft.spage=R104&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2750 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Macrophages; Immunoregulation; Data processing; Apoptosis; Synovium; Tumor necrosis factor; Leukocytes (neutrophilic); Joint diseases; Cell culture; Immunomodulation; Lymph nodes; Immunization; Inflammation; Cell activation; Foxp3 protein; Phagocytes; Arthritis; Bone loss; Lymphocytes T; Lipopolysaccharides; Cytokines; Thymocytes; Cell walls; Streptococcus DO - http://dx.doi.org/10.1186/ar2750 ER - TY - JOUR T1 - The SaeR/S Gene Regulatory System Is Essential for Innate Immune Evasion by Staphylococcus aureus AN - 20756349; 10190602 AB - Methicillin-resistant Staphylococcus aureus is problematic both in hospitals and in the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S 2-component gene regulatory system and studied its role in mouse models of pathogenesis and during human neutrophil interaction. In this study, we demonstrate that saeR/S plays a distinct role in S. aureus pathogenesis and is vital for virulence of MW2 in a mouse model of sepsis. Moreover, deletion of saeR/S significantly impaired survival of MW2 in human blood and after neutrophil phagocytosis. Microarray analysis revealed that SaeR/S of MW2 influences expression of a wide variety of genes with diverse biological functions. These data provide new insight into how virulence is regulated in S. aureus and associates a specific staphylococcal gene-regulatory system with invasive staphylococcal disease. JF - Journal of Infectious Diseases AU - Voyich, Jovanka M AU - Vuong, Cuong AU - DeWald, Mark AU - Nygaard, Tyler K AU - Kocianova, Stanislava AU - Griffith, Shannon AU - Jones, Jennifer AU - Iverson, Courtney AU - Sturdevant, Daniel E AU - Braughton, Kevin R AU - Whitney, Adeline R AU - Otto, Michael AU - DeLeo, Frank R AD - Department of Veterinary Molecular Biology, Montana State University, Bozeman, and Laboratory of Human Bacterial Pathogenesis and Genomics Unit, Research Technologies Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, jovanka@montana.edu Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1698 EP - 1706 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 11 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Immunology Abstracts KW - Cell survival KW - Deletion mutant KW - Data processing KW - Drug resistance KW - Leukocytes (neutrophilic) KW - Animal models KW - Virulence KW - Blood KW - Sepsis KW - Gene regulation KW - S gene KW - Staphylococcus aureus KW - Phagocytosis KW - Hospitals KW - J 02410:Animal Diseases KW - G 07870:Mammals KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20756349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=The+SaeR%2FS+Gene+Regulatory+System+Is+Essential+for+Innate+Immune+Evasion+by+Staphylococcus+aureus&rft.au=Voyich%2C+Jovanka+M%3BVuong%2C+Cuong%3BDeWald%2C+Mark%3BNygaard%2C+Tyler+K%3BKocianova%2C+Stanislava%3BGriffith%2C+Shannon%3BJones%2C+Jennifer%3BIverson%2C+Courtney%3BSturdevant%2C+Daniel+E%3BBraughton%2C+Kevin+R%3BWhitney%2C+Adeline+R%3BOtto%2C+Michael%3BDeLeo%2C+Frank+R&rft.aulast=Voyich&rft.aufirst=Jovanka&rft.date=2009-01-01&rft.volume=199&rft.issue=11&rft.spage=1698&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F598967 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Cell survival; Data processing; Deletion mutant; Drug resistance; Animal models; Leukocytes (neutrophilic); Virulence; Blood; Sepsis; Gene regulation; S gene; Phagocytosis; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1086/598967 ER - TY - JOUR T1 - Common Gene Variants in the Tumor Necrosis Factor (TNF) and TNF Receptor Superfamilies and NF-kB Transcription Factors and Non-Hodgkin Lymphoma Risk AN - 20741180; 9305299 AB - Background A promoter polymorphism in the pro-inflammatory cytokine tumor necrosis factor (TNF) (TNF G-308A) is associated with increased non-Hodgkin lymphoma (NHL) risk. The protein product, TNF-I-, activates the nuclear factor kappa beta (NF-IoB) transcription factor, and is critical for inflammatory and apoptotic responses in cancer progression. We hypothesized that the TNF and NF-IoB pathways are important for NHL and that gene variations across the pathways may alter NHL risk. Methodology/Principal Findings We genotyped 500 tag single nucleotide polymorphisms (SNPs) from 48 candidate gene regions (defined as 20 kb 5a2, 10 kb 3a2) in the TNF and TNF receptor superfamilies and the NF-IoB and related transcription factors, in 1946 NHL cases and 1808 controls pooled from three independent population-based case-control studies. We obtaineded a gene region-level summary of association by computing the minimum p-value (aminP testa). We used logistic regression to compute odds ratios and 95% confidence intervals for NHL and four major NHL subtypes in relation to SNP genotypes and haplotypes. For NHL, the tail strength statistic supported an overall relationship between the TNF/NF-IoB pathway and NHL (p = 0.02). We confirmed the association between TNF/LTA on chromosome 6p21.3 with NHL and found the LTA rs2844484 SNP most significantly and specifically associated with the major subtype, diffuse large B-cell lymphoma (DLBCL) (p-trend = 0.001). We also implicated for the first time, variants in NFKBIL1 on chromosome 6p21.3, associated with NHL. Other gene regions identified as statistically significantly associated with NHL included FAS, IRF4, TNFSF13B, TANK, TNFSF7 and TNFRSF13C. Accordingly, the single most significant SNPs associated with NHL were FAS rs4934436 (p-trend = 0.0024), IRF4 rs12211228 (p-trend = 0.0026), TNFSF13B rs2582869 (p-trend = 0.0055), TANK rs1921310 (p-trend = 0.0025), TNFSF7 rs16994592 (p-trend = 0.0024), and TNFRSF13C rs6002551 (p-trend = 0.0074). All associations were consistent in each study with no apparent specificity for NHL subtype. Conclusions/Significance Our results provide consistent evidence that variation in the TNF superfamily of genes and specifically within chromosome 6p21.3 impacts lymphomagenesis. Further characterization of these susceptibility loci and identification of functional variants are warranted. JF - PLoS ONE AU - Wang, Sophia S AU - Purdue, Mark P AU - Cerhan, James R AU - Zheng, Tongzhang AU - Menashe, Idan AU - Armstrong, Bruce K AU - Lan, Qing AU - Hartge, Patricia AU - Kricker, Anne AU - Zhang, Yawei AU - Morton, Lindsay M AU - Vajdic, Claire M AU - Holford, Theodore R AU - Severson, Richard K AU - Grulich, Andrew AU - Leaderer, Brian P AU - Davis, Scott AU - Cozen, Wendy AU - Yeager, Meredith AU - Chanock, Stephen J AU - Chatterjee, Nilanjan AU - Rothman, Nathaniel AU - Bauer, Joseph Alan AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 4 IS - 4 SN - 1932-6203, 1932-6203 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - double prime B-cell lymphoma KW - Apoptosis KW - Tails KW - Gene polymorphism KW - Interferon regulatory factor 4 KW - Tumor necrosis factor KW - Tumor necrosis factor receptors KW - chromosome 6 KW - Cancer KW - Inflammation KW - NF- Kappa B protein KW - Haplotypes KW - Fas antigen KW - Single-nucleotide polymorphism KW - Transcription factors KW - Cytokines KW - CD95 antigen KW - A 01310:Products of Microorganisms KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20741180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Common+Gene+Variants+in+the+Tumor+Necrosis+Factor+%28TNF%29+and+TNF+Receptor+Superfamilies+and+NF-kB+Transcription+Factors+and+Non-Hodgkin+Lymphoma+Risk&rft.au=Wang%2C+Sophia+S%3BPurdue%2C+Mark+P%3BCerhan%2C+James+R%3BZheng%2C+Tongzhang%3BMenashe%2C+Idan%3BArmstrong%2C+Bruce+K%3BLan%2C+Qing%3BHartge%2C+Patricia%3BKricker%2C+Anne%3BZhang%2C+Yawei%3BMorton%2C+Lindsay+M%3BVajdic%2C+Claire+M%3BHolford%2C+Theodore+R%3BSeverson%2C+Richard+K%3BGrulich%2C+Andrew%3BLeaderer%2C+Brian+P%3BDavis%2C+Scott%3BCozen%2C+Wendy%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BChatterjee%2C+Nilanjan%3BRothman%2C+Nathaniel%3BBauer%2C+Joseph+Alan&rft.aulast=Wang&rft.aufirst=Sophia&rft.date=2009-01-01&rft.volume=4&rft.issue=4&rft.spage=e5360&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0005360 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Apoptosis; double prime B-cell lymphoma; Tails; Tumor necrosis factor; Interferon regulatory factor 4; Gene polymorphism; Cancer; chromosome 6; Tumor necrosis factor receptors; NF- Kappa B protein; Inflammation; Haplotypes; Single-nucleotide polymorphism; Fas antigen; Transcription factors; CD95 antigen; Cytokines DO - http://dx.doi.org/10.1371/journal.pone.0005360 ER - TY - JOUR T1 - Limited Transcriptional Responses of Rickettsia rickettsii Exposed to Environmental Stimuli AN - 20662260; 9421660 AB - Rickettsiae are strict obligate intracellular pathogens that alternate between arthropod and mammalian hosts in a zoonotic cycle. Typically, pathogenic bacteria that cycle between environmental sources and mammalian hosts adapt to the respective environments by coordinately regulating gene expression such that genes essential for survival and virulence are expressed only upon infection of mammals. Temperature is a common environmental signal for upregulation of virulence gene expression although other factors may also play a role. We examined the transcriptional responses of Rickettsia rickettsii, the agent of Rocky Mountain spotted fever, to a variety of environmental signals expected to be encountered during its life cycle. R. rickettsii exposed to differences in growth temperature (25ADGC vs. 37ADGC), iron limitation, and host cell species displayed nominal changes in gene expression under any of these conditions with only 0, 5, or 7 genes, respectively, changing more than 3-fold in expression levels. R. rickettsii is not totally devoid of ability to respond to temperature shifts as cold shock (37ADGC vs. 4ADGC) induced a change greater than 3-fold in up to 56 genes. Rickettsiae continuously occupy a relatively stable environment which is the cytosol of eukaryotic cells. Because of their obligate intracellular character, rickettsiae are believed to be undergoing reductive evolution to a minimal genome. We propose that their relatively constant environmental niche has led to a minimal requirement for R. rickettsii to respond to environmental changes with a consequent deletion of non-essential transcriptional response regulators. A minimal number of predicted transcriptional regulators in the R. rickettsii genome is consistent with this hypothesis. JF - PLoS ONE AU - Ellison, Damon W AU - Clark, Tina R AU - Sturdevant, Daniel E AU - Virtaneva, Kimmo AU - Hackstadt, Ted AU - Herman, Christophe AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infections Diseases, National Institutes of Health, Hamilton, Montana, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 4 IS - 5 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Temperature effects KW - Life cycle KW - Survival KW - Transcription KW - Pathogens KW - Infection KW - Virulence KW - Gene expression KW - Rocky Mountain spotted fever KW - Arthropoda KW - Environmental changes KW - Cytosol KW - Environmental effects KW - Rickettsia rickettsii KW - Cold shock KW - Iron KW - Evolution KW - J 02410:Animal Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20662260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Limited+Transcriptional+Responses+of+Rickettsia+rickettsii+Exposed+to+Environmental+Stimuli&rft.au=Ellison%2C+Damon+W%3BClark%2C+Tina+R%3BSturdevant%2C+Daniel+E%3BVirtaneva%2C+Kimmo%3BHackstadt%2C+Ted%3BHerman%2C+Christophe&rft.aulast=Ellison&rft.aufirst=Damon&rft.date=2009-01-01&rft.volume=4&rft.issue=5&rft.spage=e5612&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0005612 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; Genomes; Transcription; Survival; Life cycle; Pathogens; Infection; Gene expression; Virulence; Rocky Mountain spotted fever; Environmental changes; Environmental effects; Cytosol; Cold shock; Iron; Evolution; Arthropoda; Rickettsia rickettsii DO - http://dx.doi.org/10.1371/journal.pone.0005612 ER - TY - JOUR T1 - The MUC1 oncoprotein as a functional target: Immunotoxin binding to alpha / beta junction mediates cell killing AN - 20628111; 9356006 AB - MUC1, a heavily glycosylated mucin, has generated considerable interest as a target for tumor killing because of its overexpression in malignancies. Full-length MUC1 (MUC1/TM) is proteolytically cleaved after synthesis generating and subunits, which specifically bind in a noncovalent interaction. Although the chain remains on the cell surface, the chain binds in an on-and-off interaction. Most anti-MUC1 antibodies (Abs) described to date recognize epitopes within the highly immunogenic -chain tandem repeat. Because the -chain is shed, such Abs are sequestered and fail to reach MUC1-expressing cells. Immunizing with cDNA encoding MUC1/TM and the spliced MUC1/X isoform from which the tandem repeat has been deleted yielded antibodies to the MUC1 / junction. Pseudomonas toxin PE38 linked to polyclonal anti-MUC1 / junction Abs both bound and killed MUC1-positive malignant cells. Monoclonal DMC209 binds the MUC1 / junction in both MUC1/X and MUC1/TM. When injected into SCID mice xenotransplanted with human breast cancer MDA-MB-231, monoclonal DMC209 showed significant in vivo tumor-suppressive activity. The MUC1/X / junction presents a biologically-significant target in MUC1-expressing malignancies because (i) antibodies directed against cell-bound / junction epitopes reach the intended cellular target, (ii) antibodies to junction epitope are internalized into cells, (iii) anti / junction antibodies can effectively kill high MUC1-expressing cancer cells as antibody-toxin conjugates and (iv) antibodies targeting the MUC1 cell-bound / junction results in tumor suppression in vivo. Our results indicate that cell-bound MUC1 / junction, unlike shed alpha chain, represents a highly effective moiety for targeting and killing MUC1-expressing malignancies. JF - International Journal of Cancer AU - Rubinstein, Daniel B AU - Karmely, Maya AU - Pichinuk, Edward AU - Ziv, Ravit AU - Benhar, Itai AU - Feng, Ningping AU - Smorodinsky, Nechama I AU - Wreschner, Daniel H AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, danielhw@post.tau.ac.il Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 46 EP - 54 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 1 SN - 0020-7136, 0020-7136 KW - Microbiology Abstracts B: Bacteriology; Oncogenes & Growth Factors Abstracts; Immunology Abstracts KW - Cell surface KW - Antibodies KW - Malignancy KW - Immunogenicity KW - mucin KW - Breast cancer KW - Pseudomonas KW - Tumors KW - Epitopes KW - Immunotoxins KW - Toxins KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - J 02350:Immunology KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20628111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+review+of+neurobiology&rft.atitle=Neural+and+cardiac+toxicities+associated+with+3%2C4-methylenedioxymethamphetamine+%28MDMA%29.&rft.au=Baumann%2C+Michael+H%3BRothman%2C+Richard+B&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2009-01-01&rft.volume=88&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=International+review+of+neurobiology&rft.issn=00747742&rft_id=info:doi/10.1016%2FS0074-7742%2809%2988010-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell surface; Malignancy; Antibodies; Immunogenicity; mucin; Breast cancer; Tumors; Toxins; Immunotoxins; Epitopes; Pseudomonas DO - http://dx.doi.org/10.1002/ijc.23910 ER - TY - JOUR T1 - Serum pepsinogens and risk of esophageal squamous dysplasia AN - 20627474; 9356061 AB - Pepsinogens are a class of endopeptidases that are secreted by the gastric epithelium and released into the circulation. Low serum pepsinogen I (PGI) and low serum pepsinogen I/pepsinogen II ratio (PGI/II ratio) are markers of gastric fundic atrophy, and have recently been shown to be associated with increased risk of esophageal squamous cell carcinoma (ESCC). We conducted the current study to test whether these markers are also associated with esophageal squamous dysplasia (ESD), the precursor lesion of ESCC. We measured serum PGI and PGII, using enzyme-linked immunosorbent assays, in 125 case subjects (patients with moderate or severe ESD) and 250 sex-matched control subjects (no ESD) selected from an endoscopic screening study in Linxian, China. We used conditional logistic regression models adjusted for age, smoking and place of residence to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs). Serum PGI showed no statistically significant association with ESD, whether analyzed as a dichotomous, ordinal (quartiles) or continuous variable. Lower serum PGI/II ratio, however, showed a dose-response association with increased risk of ESD, with an adjusted OR (95% CI) of 2.12 (1.08-4.18), comparing the lowest versus the highest quartile. The association between the lower serum PGI/II ratio and log OR of ESD was nearly linear, and the p-value for the continuous association was 0.03. Lower serum PGI/II ratio was linearly associated with higher risk of ESD. This result is consistent with recent findings that gastric atrophy may increase the risk of ESCC. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Kamangar, Farin AU - Diaw, Lena AU - Wei, Wen-Qiang AU - Abnet, Christian C AU - Wang, Guo-Qing AU - Roth, Mark J AU - Liu, Bing AU - Lu, Ning AU - Giffen, Carol AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, kamangaf@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 456 EP - 460 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 124 IS - 2 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Smoking KW - Age KW - Dose-response effects KW - Lesions KW - China, People's Rep. KW - medical instruments KW - Immunoassays KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20627474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Serum+pepsinogens+and+risk+of+esophageal+squamous+dysplasia&rft.au=Kamangar%2C+Farin%3BDiaw%2C+Lena%3BWei%2C+Wen-Qiang%3BAbnet%2C+Christian+C%3BWang%2C+Guo-Qing%3BRoth%2C+Mark+J%3BLiu%2C+Bing%3BLu%2C+Ning%3BGiffen%2C+Carol%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2009-01-01&rft.volume=124&rft.issue=2&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23918 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smoking; Age; Dose-response effects; Lesions; medical instruments; Immunoassays; Cancer; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.23918 ER - TY - JOUR T1 - A prospective study of loss of control eating for body weight gain in children at high risk for adult obesity AN - 20556254; 9268159 AB - Objective Limited data suggest that disordered-eating may predispose children to excessive weight gain. We investigated the relationship between baseline responses to the Eating Disorder Examination adapted for Children (ChEDE) and change in BMI (kg/m2) in children at high risk for adult obesity. Method Children (6-12 years) were administered the ChEDE to assess loss of control (LOC) eating, dietary restraint, and eating, shape, and weight concern. Height and weight were measured at baseline and annually. Results Between July, 1999, and August, 2007, 772 measurements were obtained from 143 children over 4.5 ± 1.9 years. LOC eating predicted an increased rate of BMI growth over time (p = .02). Compared with children without LOC, those reporting LOC gained an additional mean 2.4 kg of weight per year. Conclusion LOC is a salient predictor of weight gain during middle childhood. Interventions that decrease LOC eating should be evaluated for their ability to prevent excessive pediatric weight gain. JF - International Journal of Eating Disorders AU - Tanofsky-Kraff, Marian AU - Yanovski, Susan Z AU - Schvey, Natasha A AU - Olsen, Cara H AU - Gustafson, Jennifer AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), DHHS, Bethesda, Maryland, mtanofsky@usuhs.edu Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 26 EP - 30 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 42 IS - 1 SN - 0276-3478, 0276-3478 KW - Physical Education Index; Risk Abstracts KW - Diets KW - Measurement KW - Obesity KW - Eating disorders KW - Body mass KW - obesity KW - Diet (weight control) KW - Height KW - Adults KW - Children KW - eating disorders KW - intervention KW - Objectives KW - body weight KW - R2 23110:Psychological aspects KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20556254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Eating+Disorders&rft.atitle=A+prospective+study+of+loss+of+control+eating+for+body+weight+gain+in+children+at+high+risk+for+adult+obesity&rft.au=Tanofsky-Kraff%2C+Marian%3BYanovski%2C+Susan+Z%3BSchvey%2C+Natasha+A%3BOlsen%2C+Cara+H%3BGustafson%2C+Jennifer%3BYanovski%2C+Jack+A&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2009-01-01&rft.volume=42&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Eating+Disorders&rft.issn=02763478&rft_id=info:doi/10.1002%2Feat.20580 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Measurement; Eating disorders; Objectives; Body mass; Diet (weight control); Height; Adults; Children; Diets; eating disorders; intervention; obesity; body weight DO - http://dx.doi.org/10.1002/eat.20580 ER - TY - JOUR T1 - Crystallization and preliminary X-ray diffraction analyses of several forms of the CfaB major subunit of enterotoxigenic Escherichia coli CFA/I fimbriae AN - 20548261; 9256686 AB - Enterotoxigenic Escherichia coli (ETEC), a major global cause of diarrhea, initiates the pathogenic process via fimbriae-mediated attachment to the small intestinal epithelium. A common prototypic ETEC fimbria, colonization factor antigen I (CFA/I), consists of a tip-localized minor adhesive subunit CfaE and the stalk-forming major subunit CfaB, both of which are necessary for fimbrial assembly. To elucidate the structure of CFA/I at atomic resolution, three recombinant proteins were generated consisting of fusions of the minor and major subunits (CfaEB) and of two (CfaBB) and three (CfaBBB) repeats of the major subunit. Crystals of CfaEB diffracted X-rays to 2.1Aa resolution and displayed the symmetry of space group P21. CfaBB exhibited a crystal diffraction limit of 2.3Aa resolution and had the symmetry of space group P21212. CfaBBB crystallized in the monoclinic space group C2 and diffracted X-rays to 2.3Aa resolution. These structures were determined using the molecular-replacement method. JF - Acta Crystallographica Section F AU - Li, Yong-Fu AU - Poole, Steven AU - Rasulova, Fatima AU - McVeigh, Annette L AU - Savarino, Stephen J AU - Xia, Di AD - aLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4256, USA, dixia@helix.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 242 EP - 247 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 65 IS - 3 SN - 1744-3091, 1744-3091 KW - Microbiology Abstracts B: Bacteriology KW - colonization factor antigen I fimbriae KW - CfaB subunit KW - enterotoxigenic Escherichia coli KW - Crystallization KW - Diarrhea KW - Crystals KW - X-ray diffraction KW - Pili KW - Ionizing radiation KW - Escherichia coli KW - Intestine KW - Epithelium KW - Adhesives KW - Fimbria KW - Colonization factor KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20548261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+F&rft.atitle=Crystallization+and+preliminary+X-ray+diffraction+analyses+of+several+forms+of+the+CfaB+major+subunit+of+enterotoxigenic+Escherichia+coli+CFA%2FI+fimbriae&rft.au=Li%2C+Yong-Fu%3BPoole%2C+Steven%3BRasulova%2C+Fatima%3BMcVeigh%2C+Annette+L%3BSavarino%2C+Stephen+J%3BXia%2C+Di&rft.aulast=Li&rft.aufirst=Yong-Fu&rft.date=2009-01-01&rft.volume=65&rft.issue=3&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+F&rft.issn=17443091&rft_id=info:doi/10.1107%2FS1744309109001584 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Crystallization; Diarrhea; Pili; Ionizing radiation; Intestine; Epithelium; Crystals; Adhesives; X-ray diffraction; Colonization factor; Escherichia coli; Fimbria DO - http://dx.doi.org/10.1107/S1744309109001584 ER - TY - JOUR T1 - Normal regional fractional anisotropy and apparent diffusion coefficient of the brain measured on a 3 T MR scanner AN - 20531150; 9198411 AB - Introduction: We aim to establish norms of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in 20 different regions of the brain in healthy human volunteers. Methods: Thirty-one individuals were examined for ADC and FA in 20 regions of the brain using a single-shot, spin echo, echo planar diffusion tensor imaging sequence with 32 directions at 3 T. FA and ADC maps were computed using the Philips PRIDE tool, and regions of interest were drawn at 20 different locations in the brain. Relationships of FA and ADC with age and gender were explored. Results: We found a negative correlation between age and FA in the inferior fronto-occipital fasciculus and forceps minor. There were no gender differences. The cerebral peduncle, the middle cerebellum, and cingulum had the highest variation in FA, while fornix, optic radiation, and optic tract had the highest variation in ADC. Conclusion: We provide a table of normative FA and ADC measurements in 20 brain regions of potential clinical relevance to the diagnosis and monitoring of specific neurological diseases. JF - Neuroradiology AU - Lee, Christabel EC AU - Danielian, Laura E AU - Thomasson, David AU - Baker, Eva H AD - Department of Diagnostic Radiology, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA, leechrist@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 3 EP - 9 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 51 IS - 1 SN - 0028-3940, 0028-3940 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Optic tract KW - Age KW - Neurological diseases KW - Anisotropy KW - Magnetic resonance imaging KW - Cerebellum KW - Brain KW - Sex differences KW - Cingulum KW - Radiation KW - Fornix KW - Diffusion coefficient KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroradiology&rft.atitle=Normal+regional+fractional+anisotropy+and+apparent+diffusion+coefficient+of+the+brain+measured+on+a+3+T+MR+scanner&rft.au=Lee%2C+Christabel+EC%3BDanielian%2C+Laura+E%3BThomasson%2C+David%3BBaker%2C+Eva+H&rft.aulast=Lee&rft.aufirst=Christabel&rft.date=2009-01-01&rft.volume=51&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Neuroradiology&rft.issn=00283940&rft_id=info:doi/10.1007%2Fs00234-008-0441-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Age; Optic tract; Anisotropy; Neurological diseases; Magnetic resonance imaging; Brain; Cerebellum; Sex differences; Cingulum; Fornix; Radiation; Diffusion coefficient DO - http://dx.doi.org/10.1007/s00234-008-0441-3 ER - TY - JOUR T1 - The TRPC Class of Ion Channels: A Critical Review of Their Roles in Slow, Sustained Increases in Intracellular Ca2+ Concentrations AN - 20525737; 9210011 AB - The realization that there exists a multimembered family of cation channels with structural similarity to Drosophila's Trp channel emerged during the second half of the 1990s. In mammals, depending on the species, the TRP family counts 29 or 30 members which has been subdivided into 6 subfamilies on the basis of sequence similarity. TRP channels are nonselective monovalent cation channels, most of which also allow passage of Ca super(2+). Many members of each of these families, but not all, are involved in sensory signal transduction. The C-type (for canonical or classical) subfamily, differs from the other TRP subfamilies in that it fulfills two different types of function: membrane depolarization, resembling sensory transduction TRPs, and mediation of sustained increases in intracellular Ca super(2+). The mechanism(s) by which the C-class of TRP channels-the TRPCs-are activated is poorly understood and their role in mediating intracellular Ca super(2+) increases is being questioned. Both of these questions-mechanism of activation and participation in Ca super(2+) entry-are the topics of this review. JF - Annual Review of Pharmacology and Toxicology AU - Birnbaumer, Lutz AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, birnbau1@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 395 EP - 426 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 49 SN - 0362-1642, 0362-1642 KW - Entomology Abstracts; Calcium & Calcified Tissue Abstracts; Toxicology Abstracts KW - cation channels KW - Calcium KW - Reviews KW - Ion channels KW - transient receptor potential proteins KW - sensory transduction KW - Drosophila KW - Calcium (intracellular) KW - Signal transduction KW - Membrane potential KW - Depolarization KW - Z 05300:General KW - X 24310:Pharmaceuticals KW - T 2000:Cellular Calcium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20525737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Pharmacology+and+Toxicology&rft.atitle=The+TRPC+Class+of+Ion+Channels%3A+A+Critical+Review+of+Their+Roles+in+Slow%2C+Sustained+Increases+in+Intracellular+Ca2%2B+Concentrations&rft.au=Birnbaumer%2C+Lutz&rft.aulast=Birnbaumer&rft.aufirst=Lutz&rft.date=2009-01-01&rft.volume=49&rft.issue=&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Pharmacology+and+Toxicology&rft.issn=03621642&rft_id=info:doi/10.1146%2Fannurev.pharmtox.48.113006.094928 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - cation channels; Calcium; Reviews; Ion channels; sensory transduction; transient receptor potential proteins; Depolarization; Membrane potential; Signal transduction; Calcium (intracellular); Drosophila DO - http://dx.doi.org/10.1146/annurev.pharmtox.48.113006.094928 ER - TY - JOUR T1 - Cancer Screening: The Clash of Science and Intuition AN - 20525618; 9209921 AB - The concept of early detection of cancer holds great promise and intuitive appeal. However, powerful biases can mislead clinicians when evaluating the efficacy of screening tests by clinical observation alone. Selection bias, lead-time bias, length-biased sampling, and overdiagnosis are counterintuitive concepts with critical implications for early-detection efforts. This article explains these biases and other common confounders in cancer screening. The most direct and reliable way to avoid being led astray by intuitions is through the use of randomized controlled trials. JF - Annual Review of Medicine AU - Kramer, Barnett S AU - Croswell, Jennifer Miller AD - Office of Disease Prevention, Office of the Director, National Institutes of Health, Bethesda, Maryland 20892, bk76p@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 125 EP - 137 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 60 SN - 0066-4219, 0066-4219 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Sampling KW - Clinical trials KW - Cancer KW - Lead KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20525618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=Cancer+Screening%3A+The+Clash+of+Science+and+Intuition&rft.au=Kramer%2C+Barnett+S%3BCroswell%2C+Jennifer+Miller&rft.aulast=Kramer&rft.aufirst=Barnett&rft.date=2009-01-01&rft.volume=60&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.60.101107.134802 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Reviews; Sampling; Clinical trials; Lead; Cancer DO - http://dx.doi.org/10.1146/annurev.med.60.101107.134802 ER - TY - JOUR T1 - The HapMap and Genome-Wide Association Studies in Diagnosis and Therapy AN - 20523645; 9209944 AB - The International HapMap Project produced a genome-wide database of human genetic variation for use in genetic association studies of common diseases. The initial output of these studies has been overwhelming, with over 150 risk loci identified in studies of more than 60 common diseases and traits. These associations have suggested previously unsuspected etiologic pathways for common diseases that will be of use in identifying new therapeutic targets and developing targeted interventions based on genetically defined risk. Here we examine the development and application of the HapMap to genome-wide association (GWA) studies; present and future technologies for GWA research; current major efforts in GWA studies; successes and limitations of the GWA approach in identifying polymorphisms related to complex diseases; data release and privacy polices; use of these findings by clinicians, the public, and academic physicians; and sources of ongoing authoritative information on this rapidly evolving field. JF - Annual Review of Medicine AU - Manolio, Teri A AU - Collins, Francis S AD - National Human Genome Research Institute, Bethesda, Maryland 20892, manolio@nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 443 EP - 456 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 60 SN - 0066-4219, 0066-4219 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Databases KW - Data processing KW - Reviews KW - Genetic diversity KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20523645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Medicine&rft.atitle=The+HapMap+and+Genome-Wide+Association+Studies+in+Diagnosis+and+Therapy&rft.au=Manolio%2C+Teri+A%3BCollins%2C+Francis+S&rft.aulast=Manolio&rft.aufirst=Teri&rft.date=2009-01-01&rft.volume=60&rft.issue=&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Medicine&rft.issn=00664219&rft_id=info:doi/10.1146%2Fannurev.med.60.061907.093117 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Reviews; Genetic diversity DO - http://dx.doi.org/10.1146/annurev.med.60.061907.093117 ER - TY - JOUR T1 - Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS AN - 20509142; 9199172 AB - Objectives: To determine the incidence and outcomes of intensive care unit-acquired neuromyopathy and to investigate the role of methylprednisolone in survivors of persistent acute lung injury. Design: Secondary analysis of completed randomized placebo-controlled trial. Setting: Twenty-five hospitals in the NHLBI ARDS Network. Patients and participants: Patients enrolled in the ARDS Network study of methylprednisolone versus placebo for persistent ARDS who survived 60 days or to hospital discharge. Measurements and results: One hundred and twenty-eight study patients survived 60 days. Forty-three (34%) of these patients had evidence by chart review of ICU-acquired neuromyopathy, which was associated with prolonged mechanical ventilation, return to mechanical ventilation, and delayed return to home after critical illness. Treatment with methylprednisolone was not significantly associated with an increase in risk of neuromyopathy (OR 1.5; 95% CI 0.7-3.2). Conclusions: ICU-acquired-neuromyopathy is common among survivors of persistent ARDS and is associated with poorer clinical outcomes. We did not find a significant association between methylprednisolone treatment and neuromyopathy. Limitations of this study preclude definitive conclusions about the causal relationship between corticosteroids and ICU-acquired neuromuscular dysfunction. JF - Intensive Care Medicine AU - Hough, Catherine L AU - Steinberg, Kenneth P AU - Taylor Thompson, B AU - Rubenfeld, Gordon D AU - Hudson, Leonard D AD - Department of Medicine and The NHLBI ARDS Network, University of Washington, 325 Ninth Avenue, Mailstop 359762, Seattle, WA, 98104, USA, cterrlee@u.washington.edu Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 63 EP - 68 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 VL - 35 IS - 1 SN - 0342-4642, 0342-4642 KW - Risk Abstracts KW - Ventilation KW - Injuries KW - Lung KW - secondary analysis KW - Reviews KW - corticoids KW - Hospitals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20509142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Intensive+care+unit-acquired+neuromyopathy+and+corticosteroids+in+survivors+of+persistent+ARDS&rft.au=Hough%2C+Catherine+L%3BSteinberg%2C+Kenneth+P%3BTaylor+Thompson%2C+B%3BRubenfeld%2C+Gordon+D%3BHudson%2C+Leonard+D&rft.aulast=Hough&rft.aufirst=Catherine&rft.date=2009-01-01&rft.volume=35&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-008-1304-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Injuries; Ventilation; secondary analysis; Lung; Reviews; Hospitals; corticoids DO - http://dx.doi.org/10.1007/s00134-008-1304-4 ER - TY - JOUR T1 - Differences in the Tumor Microenvironment between African-American and European-American Breast Cancer Patients AN - 20455696; 9133118 AB - Background African-American breast cancer patients experience higher mortality rates than European-American patients despite having a lower incidence of the disease. We tested the hypothesis that intrinsic differences in the tumor biology may contribute to this cancer health disparity. Methods and Results Using laser capture microdissection, we examined genome-wide mRNA expression specific to tumor epithelium and tumor stroma in 18 African-American and 17 European-American patients. Numerous genes were differentially expressed between these two patient groups and a two-gene signature in the tumor epithelium distinguished between them. To identify the biological processes in tumors that are different by race/ethnicity, Gene Ontology and disease association analyses were performed. Several biological processes were identified which may contribute to enhanced disease aggressiveness in African-American patients, including angiogenesis and chemotaxis. African-American tumors also contained a prominent interferon signature. The role of angiogenesis in the tumor biology of African-Americans was further investigated by examining the extent of vascularization and macrophage infiltration in an expanded set of 248 breast tumors. Immunohistochemistry revealed that microvessel density and macrophage infiltration is higher in tumors of African-Americans than in tumors of European-Americans. Lastly, using an in silico approach, we explored the potential of tailored treatment options for African-American patients based on their gene expression profile. This exploratory approach generated lists of therapeutics that may have specific antagonistic activity against tumors of African-American patients, e.g., sirolimus, resveratrol, and chlorpromazine in estrogen receptor-negative tumors. Conclusions The gene expression profiles of breast tumors indicate that differences in tumor biology may exist between African-American and European-American patients beyond the knowledge of current markers. Notably, pathways related to tumor angiogenesis and chemotaxis could be functionally different in these two patient groups. JF - PLoS ONE AU - Martin, Damali N AU - Boersma, Brenda J AU - Yi, Ming AU - Reimers, Mark AU - Howe, Tiffany M AU - Yfantis, Harry G AU - Tsai, Yien Che AU - Williams, Erica H AU - Lee, Dong H AU - Stephens, Robert M AU - Weissman, Allan M AU - Ambs, Stefan AU - Seoighe, Cathal AD - Laboratory of Human Carcinogenesis, Center of Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 4 IS - 2 SN - 1932-6203, 1932-6203 KW - Ecology Abstracts; Genetics Abstracts KW - Stroma KW - Macrophages KW - Mortality KW - Association analysis KW - Estrogens KW - vascularization KW - Angiogenesis KW - Chlorpromazine KW - Tumors KW - Chemotaxis KW - Metastases KW - Gene expression KW - Resveratrol KW - alpha -Interferon KW - Breast cancer KW - Microenvironments KW - Epithelium KW - Lasers KW - sirolimus KW - Immunohistochemistry KW - Ethnic groups KW - Races KW - G 07880:Human Genetics KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20455696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Differences+in+the+Tumor+Microenvironment+between+African-American+and+European-American+Breast+Cancer+Patients&rft.au=Martin%2C+Damali+N%3BBoersma%2C+Brenda+J%3BYi%2C+Ming%3BReimers%2C+Mark%3BHowe%2C+Tiffany+M%3BYfantis%2C+Harry+G%3BTsai%2C+Yien+Che%3BWilliams%2C+Erica+H%3BLee%2C+Dong+H%3BStephens%2C+Robert+M%3BWeissman%2C+Allan+M%3BAmbs%2C+Stefan%3BSeoighe%2C+Cathal&rft.aulast=Martin&rft.aufirst=Damali&rft.date=2009-01-01&rft.volume=4&rft.issue=2&rft.spage=e4531&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0004531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Stroma; Mortality; Estrogens; Association analysis; vascularization; Angiogenesis; Chlorpromazine; Tumors; Chemotaxis; Resveratrol; Gene expression; Metastases; alpha -Interferon; Microenvironments; Breast cancer; Lasers; Epithelium; sirolimus; Immunohistochemistry; Races; Ethnic groups DO - http://dx.doi.org/10.1371/journal.pone.0004531 ER - TY - JOUR T1 - Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer AN - 20399184; 9076908 AB - Androgens and estrogens may play a role in gastric cancer etiology. To investigate the association of gastric cancer with single-nucleotide polymorphisms (SNPs) in six genes (COMT, CYP1B1, CYP17A1, CYP19A1, HSD17B1 and SHBG) involved in estrogen and androgen synthesis and metabolism, 58 haplotype-tagging SNPs were genotyped in 295 gastric cancer cases and 415 controls from a population-based study in Poland. We assessed differences in haplotype frequency between cases and controls using a global score test and calculated multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for individual haplotypes using logistic regression. We found associations in one linkage disequilibrium (LD) block containing the 3 untranslated region of COMT (rs9332377, rs165728, rs165849 and rs1110478), global score test (df=4, P=0.033). Relative to the most frequent GATA haplotype, the GATG haplotype was associated with statistically significant increased gastric cancer risk (OR=1.50, 95% CI: 1.06-2.12; false discovery rate (FDR) value=0.459) and the AACA haplotype with borderline increased risk (OR=1.36, 95% CI=1.00-1.85; FDR=0.50). We also found associations for the LD block containing part of the SHBG coding region (rs6258, rs6259, rs2955617, rs1641544 and rs1641537). The CACCC haplotype was associated with statistically significant lower gastric cancer risk relative to the referent CGACC haplotype (OR=0.55, 95% CI=0.34-0.90; FDR=0.459), but the overall score test was statistically non-significant. No other statistically significant associations were observed. In summary, we found possible associations between gastric cancer and polymorphisms in COMT, involved in estrogen inactivation, and SHBG, a modulator of hormone bioavailability. These findings should be interpreted cautiously until replicated in other studies. JF - Carcinogenesis AU - Freedman, Neal D AU - Ahn, Jiyoung AU - Hou, Lifang AU - Lissowska, Jolanta AU - Zatonski, Witold AU - Yeager, Meredith AU - Chanock, Stephen J AU - Chow, Wong Ho AU - Abnet, Christian C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA, freedmanne@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 71 EP - 77 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 30 IS - 1 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Genetics Abstracts KW - Risk assessment KW - Estrogens KW - Etiology KW - Gene polymorphism KW - Statistical analysis KW - Population studies KW - Hormones KW - Linkage disequilibrium KW - Bioavailability KW - Haplotypes KW - Single-nucleotide polymorphism KW - Risk factors KW - Carcinogenesis KW - Gastric cancer KW - Metabolism KW - Androgens KW - G 07880:Human Genetics KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20399184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+estrogen-+and+androgen-metabolizing+genes+and+the+risk+of+gastric+cancer&rft.au=Freedman%2C+Neal+D%3BAhn%2C+Jiyoung%3BHou%2C+Lifang%3BLissowska%2C+Jolanta%3BZatonski%2C+Witold%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BChow%2C+Wong+Ho%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2009-01-01&rft.volume=30&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn258 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Etiology; Estrogens; Gene polymorphism; Statistical analysis; Population studies; Hormones; Bioavailability; Linkage disequilibrium; Haplotypes; Single-nucleotide polymorphism; Risk factors; Carcinogenesis; Gastric cancer; Metabolism; Androgens DO - http://dx.doi.org/10.1093/carcin/bgn258 ER - TY - JOUR T1 - Correspondence: Asthma and obesity: An archival addendum AN - 20397448; 9068720 AB - Abstract not available. JF - Journal of Allergy and Clinical Immunology AU - Cohen, Sheldon G AD - National Institute of Allergy and Infectious Diseases and the National Library of Medicine, History of Medicine Division, National Institutes of Health, Bethesda, Md, scohen@niaid.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 265 EP - 266 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA, [mailto:membership@aaaai.org], [URL:http://www.aaai.org] VL - 123 IS - 1 SN - 0091-6749, 0091-6749 KW - Physical Education Index KW - Obesity KW - Immune system KW - Asthma KW - Allergies KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Correspondence%3A+Asthma+and+obesity%3A+An+archival+addendum&rft.au=Cohen%2C+Sheldon+G&rft.aulast=Cohen&rft.aufirst=Sheldon&rft.date=2009-01-01&rft.volume=123&rft.issue=1&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2008.07.038 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Immune system; Asthma; Allergies DO - http://dx.doi.org/10.1016/j.jaci.2008.07.038 ER - TY - JOUR T1 - Making the most of fMRI at 7 T by suppressing spontaneous signal fluctuations AN - 20393428; 9066102 AB - The presence of spontaneous BOLD fMRI signal fluctuations in human grey matter compromises the detection and interpretation of evoked responses and limits the sensitivity gains that are potentially available through coil arrays and high field systems. In order to overcome these limitations, we adapted and improved a recently described correlated noise suppression method (de Zwart et al., 2008), demonstrating improved precision in estimating the response to ultra-short visual stimuli at 7 T. In this procedure, the temporal dynamics of spontaneous signal fluctuations are estimated from a reference brain region outside the area targeted with the stimulus. Rather than using the average signal in this region as regressor, as proposed in the original method, we used principal component analysis to derive multiple regressors in order to optimally describe nuisance signals (e.g. spontaneous fluctuations) and separate these from evoked activity in the target region. Experimental results obtained from application of the original method showed a 66% improvement in estimation precision. The novel, enhanced version of the method, using 18 PCA-derived noise regressors, led to a 160% increase in precision. These increases were relative to a control condition without noise suppression, which was simulated by randomizing the time-course of the nuisance-signal regressor(s) without altering their power spectrum. The increase of estimation precision was associated with decreased autocorrelation levels of the residual errors. These results suggest that modeling of spontaneous fMRI signal fluctuations as multiple independent sources can dramatically improve detection of evoked activity, and fully exploit the potential sensitivity gains available with high field technology. JF - NeuroImage AU - Bianciardi, Marta AU - van Gelderen, Peter AU - Duyn, Jeff H AU - Fukunaga, Masaki AU - de Zwart, Jacco A AD - Advanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, Jacco.deZwart@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 448 EP - 454 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Evoked responses KW - Spontaneous signal fluctuations KW - Noise modeling KW - Correlated noise KW - Estimation precision KW - Temporal autocorrelation KW - BOLD fMRI KW - High field strength KW - Visual stimuli KW - Brain mapping KW - Data processing KW - Functional magnetic resonance imaging KW - Principal components analysis KW - W 30910:Imaging KW - N3 11002:Computational & theoretical neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20393428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Making+the+most+of+fMRI+at+7+T+by+suppressing+spontaneous+signal+fluctuations&rft.au=Bianciardi%2C+Marta%3Bvan+Gelderen%2C+Peter%3BDuyn%2C+Jeff+H%3BFukunaga%2C+Masaki%3Bde+Zwart%2C+Jacco+A&rft.aulast=Bianciardi&rft.aufirst=Marta&rft.date=2009-01-01&rft.volume=44&rft.issue=2&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.08.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Visual stimuli; Brain mapping; Data processing; Principal components analysis; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.08.037 ER - TY - JOUR T1 - Neural substrates of reward magnitude, probability, and risk during a wheel of fortune decision-making task AN - 20393320; 9066117 AB - Economic decision-making involves the weighting of magnitude and probability of potential gains/losses. While previous work has examined the neural systems involved in decision-making, there is a need to understand how the parameters associated with decision-making (e.g., magnitude of expected reward, probability of expected reward and risk) modulate activation within these neural systems. In the current fMRI study, we modified the monetary wheel of fortune (WOF) task [Ernst, M., Nelson, E.E., McClure, E.B., Monk, C.S., Munson, S., Eshel, N., et al. (2004). Choice selection and reward anticipation: an fMRI study. Neuropsychologia 42(12), 1585-1597.] to examine in 25 healthy young adults the neural responses to selections of different reward magnitudes, probabilities, or risks. Selection of high, relative to low, reward magnitude increased activity in insula, amygdala, middle and posterior cingulate cortex, and basal ganglia. Selection of low-probability, as opposed to high-probability reward, increased activity in anterior cingulate cortex, as did selection of risky, relative to safe reward. In summary, decision-making that did not involve conflict, as in the magnitude contrast, recruited structures known to support the coding of reward values, and those that integrate motivational and perceptual information for behavioral responses. In contrast, decision-making under conflict, as in the probability and risk contrasts, engaged the dorsal anterior cingulate cortex whose role in conflict monitoring is well established. However, decision-making under conflict failed to activate the structures that track reward values per se. Thus, the presence of conflict in decision-making seemed to significantly alter the pattern of neural responses to simple rewards. In addition, this paradigm further clarifies the functional specialization of the cingulate cortex in processes of decision-making. JF - NeuroImage AU - Smith, Bruce W AU - Mitchell, Derek G V AU - Hardin, Michael G AU - Jazbec, Sandra AU - Fridberg, Daniel AU - Blair, R James R AU - Ernst, Monique AD - Department of Psychology, University of New Mexico, USA, ernstm@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 600 EP - 609 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Decision making KW - Coding KW - Functional magnetic resonance imaging KW - Economics KW - Reinforcement KW - Specialization KW - Amygdala KW - Cortex (cingulate) KW - Basal ganglia KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20393320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Neural+substrates+of+reward+magnitude%2C+probability%2C+and+risk+during+a+wheel+of+fortune+decision-making+task&rft.au=Smith%2C+Bruce+W%3BMitchell%2C+Derek+G+V%3BHardin%2C+Michael+G%3BJazbec%2C+Sandra%3BFridberg%2C+Daniel%3BBlair%2C+R+James+R%3BErnst%2C+Monique&rft.aulast=Smith&rft.aufirst=Bruce&rft.date=2009-01-01&rft.volume=44&rft.issue=2&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.08.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Coding; Decision making; Functional magnetic resonance imaging; Economics; Reinforcement; Specialization; Amygdala; Basal ganglia; Cortex (cingulate) DO - http://dx.doi.org/10.1016/j.neuroimage.2008.08.016 ER - TY - JOUR T1 - Manganese enhanced MRI reveals functional circuitry in response to odorant stimuli AN - 20391383; 9066095 AB - To investigate the circuitry involved in detecting odorants in the rodent brain, we developed a method using manganese-enhanced MRI (MEMRI) to map the flow of neural information from the olfactory sensory neurons (OSNs) to the central layers of the olfactory bulb. Studies have shown that Mn2+ enters active neurons and is transported anterogradely to axon terminals where it can cross synapses to functionally trace neural networks. Thus, by delivering MnCl2 directly into the nasal cavity of mice and then exposing them to defined odorants, Mn2+ is preferentially taken up by activated OSNs. Using the time course of the MRI signal, we generated maps of Mn2+ accumulation in the olfactory bulb for both glomerular and mitral cell layers. Results demonstrated that overlapping yet distinct enhancement patterns were produced by exposure to either octanal, acetophenone, or carvone. Notably, areas of Mn2+ accumulation in the mitral cell layer were similar to those in the glomerular layer consistent with neural information that passes from specific OSNs to specific mitral cells. Finally, by correlating specific Mn2+ signal peaks to genetically labeled glomeruli that are known to be activated by the odorant octanal, we show that MEMRI maps can be resolved at the level of individual glomeruli. JF - NeuroImage AU - Chuang, Kai-Hsiang AU - Lee, Jung Hee AU - Silva, Afonso C AU - Belluscio, Leonardo AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, 10 Center Drive, 10/3D17, MSC 1488, Bethesda, MD 20892, USA, chuangk@ninds.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 363 EP - 372 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 44 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts; Chemoreception Abstracts KW - Synapses KW - Olfactory receptor neurons KW - Sensory neurons KW - Neural networks KW - Functional magnetic resonance imaging KW - Magnetic resonance imaging KW - Brain KW - Mitral cells KW - Presynapse KW - Functional anatomy KW - Carvone KW - Olfactory bulb KW - Olfactory pathways KW - Nose KW - octanal KW - Acetophenone KW - Manganese KW - Odorants KW - W 30960:Bioinformatics & Computer Applications KW - R 18000:Olfaction KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20391383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Manganese+enhanced+MRI+reveals+functional+circuitry+in+response+to+odorant+stimuli&rft.au=Chuang%2C+Kai-Hsiang%3BLee%2C+Jung+Hee%3BSilva%2C+Afonso+C%3BBelluscio%2C+Leonardo%3BKoretsky%2C+Alan+P&rft.aulast=Chuang&rft.aufirst=Kai-Hsiang&rft.date=2009-01-01&rft.volume=44&rft.issue=2&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.08.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Synapses; Olfactory receptor neurons; Sensory neurons; Neural networks; Functional magnetic resonance imaging; Magnetic resonance imaging; Brain; Mitral cells; Presynapse; Functional anatomy; Carvone; Olfactory bulb; Olfactory pathways; octanal; Nose; Acetophenone; Manganese; Odorants DO - http://dx.doi.org/10.1016/j.neuroimage.2008.08.046 ER - TY - JOUR T1 - Chlamydia trachomatis Polymorphic Membrane Protein D Is an Oligomeric Autotransporter with a Higher-Order Structure AN - 20386186; 9065290 AB - Chlamydia trachomatis is a globally important obligate intracellular bacterial pathogen that is a leading cause of sexually transmitted disease and blinding trachoma. Effective control of these diseases will likely require a preventative vaccine. C. trachomatis polymorphic membrane protein D (PmpD) is an attractive vaccine candidate as it is conserved among C. trachomatis strains and is a target of broadly cross-reactive neutralizing antibodies. We show here that immunoaffinity-purified native PmpD exists as an oligomer with a distinct 23-nm flower-like structure. Two-dimensional blue native-sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses showed that the oligomers were composed of full-length PmpD (p155) and two proteolytically processed fragments, the p73 passenger domain (PD) and the p82 translocator domain. We also show that PmpD undergoes an infection-dependent proteolytic processing step late in the growth cycle that yields a soluble extended PD (p111) that was processed into a p73 PD and a novel p30 fragment. Interestingly, soluble PmpD peptides possess putative eukaryote-interacting functional motifs, implying potential secondary functions within or distal to infected cells. Collectively, our findings show that PmpD exists as two distinct forms, a surface-associated oligomer exhibiting a higher-order flower-like structure and a soluble form restricted to infected cells. We hypothesize that PmpD is a multifunctional virulence factor important in chlamydial pathogenesis and could represent novel vaccine or drug targets for the control of human chlamydial infections. JF - Infection and Immunity AU - Swanson, Kena A AU - Taylor, Lacey D AU - Frank, Shaun D AU - Sturdevant, Gail L AU - Fischer, Elizabeth R AU - Carlson, John H AU - Whitmire, William M AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites. Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 508 EP - 516 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 77 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Proteolysis KW - virulence factors KW - Sexually-transmitted diseases KW - Chlamydia trachomatis KW - Membrane proteins KW - Pathogens KW - Infection KW - Gel electrophoresis KW - Trachoma KW - Antibodies KW - Vaccines KW - Drugs KW - A 01490:Miscellaneous KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20386186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Chlamydia+trachomatis+Polymorphic+Membrane+Protein+D+Is+an+Oligomeric+Autotransporter+with+a+Higher-Order+Structure&rft.au=Swanson%2C+Kena+A%3BTaylor%2C+Lacey+D%3BFrank%2C+Shaun+D%3BSturdevant%2C+Gail+L%3BFischer%2C+Elizabeth+R%3BCarlson%2C+John+H%3BWhitmire%2C+William+M%3BCaldwell%2C+Harlan+D&rft.aulast=Swanson&rft.aufirst=Kena&rft.date=2009-01-01&rft.volume=77&rft.issue=1&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Proteolysis; Antibodies; Sexually-transmitted diseases; virulence factors; Pathogens; Membrane proteins; Vaccines; Infection; Drugs; Gel electrophoresis; Trachoma; Chlamydia trachomatis ER - TY - JOUR T1 - Multiecho dixon fat and water separation method for detecting fibrofatty infiltration in the myocardium AN - 20373610; 9058293 AB - Conventional approaches for fat and water discrimination based on chemical-shift fat suppression have reduced ability to characterize fatty infiltration due to poor contrast of microscopic fat. The multiecho Dixon approach to water and fat separation has advantages over chemical-shift fat suppression: 1) water and fat images can be acquired in a single breathhold, avoiding misregistration; 2) fat has positive contrast; 3) the method is compatible with precontrast and late-enhancement imaging, 4) less susceptible to partial-volume effects, and 5) robust in the presence of background field variation; and 6) for the bandwidth implemented, chemical-shift artifact is decreased. The proposed technique was applied successfully in all 28 patients studied. This included 10 studies with indication of coronary artery disease (CAD), of which four cases with chronic myocardial infarction (MI) exhibited fatty infiltration; 13 studies to rule out arrhythmogenic right ventricular cardiomyopathy (ARVC), of which there were three cases with fibrofatty infiltration and two confirmed with ARVC; and five cases of cardiac masses (two lipomas). The precontrast contrast-to-noise ratio (CNR) of intramyocardial fat was greatly improved, by 240% relative to conventional fat suppression. For the parameters implemented, the signal-to-noise ratio (SNR) was decreased by 30% relative to conventional late enhancement. The multiecho Dixon method for fat and water separation provides a sensitive means of detecting intramyocardial fat with positive signal contrast. Magn Reson Med 61:215-221, 2009. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Hernando, Diego AU - Shah, Saurabh AU - Zuehlsdorff, Sven AU - Jerecic, Renate AU - Mancini, Christine AU - Liang, Zhi-Pei AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS), Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 215 EP - 221 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 61 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Cardiomyopathy KW - Ventricle KW - N.M.R. KW - lipoma KW - imaging KW - Myocardial infarction KW - Heart diseases KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Multiecho+dixon+fat+and+water+separation+method+for+detecting+fibrofatty+infiltration+in+the+myocardium&rft.au=Kellman%2C+Peter%3BHernando%2C+Diego%3BShah%2C+Saurabh%3BZuehlsdorff%2C+Sven%3BJerecic%2C+Renate%3BMancini%2C+Christine%3BLiang%2C+Zhi-Pei%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21657 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Cardiomyopathy; Ventricle; N.M.R.; lipoma; imaging; Myocardial infarction; Myocardium; Heart diseases DO - http://dx.doi.org/10.1002/mrm.21657 ER - TY - JOUR T1 - Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States AN - 20368472; 9054542 AB - Objective: Immunosuppression may increase risk for some skin cancers. We evaluated skin cancer epidemiology among persons with AIDS. Design: We linked data from population-based US AIDS and cancer registries to evaluate risk of nonkeratinocytic skin cancers (melanoma, Merkel cell carcinoma, and appendageal carcinomas, including sebaceous carcinoma) in 497142 persons with AIDS. Methods: Standardized incidence ratios (SIRs) were calculated to relate skin cancer risk to that in the general population. We used logistic regression to compare risk according to demographic factors, CD4 cell count, and a geographic index of ultraviolet radiation exposure. Results: From 60 months before to 60 months after AIDS onset, persons with AIDS had elevated risks of melanoma (SIR = 1.3, 95% confidence interval 1.1-1.4, n = 292 cases) and, more strongly, of Merkel cell carcinoma (SIR= 11, 95% confidence interval 6.3-17, n = 17) and sebaceous carcinoma (SIR = 8.1, 95% confidence interval 3.2-17, n = 7). Risk for appendageal carcinomas increased with progressive time relative to AIDS onset (P trend = 0.03). Risk of these skin cancers was higher in non-Hispanic whites than other racial/ethnic groups, and melanoma risk was highest among men who have sex with men. Melanoma risk was unrelated to CD4 cell count at AIDS onset (P=0.32). Risks for melanoma and appendageal carcinomas rose with increasing ultraviolet radiation exposure (P trend <10 super(-4) and P trend = 10 super(-3), respectively). Conclusion: Among persons with AIDS, there is a modest excess risk of melanoma, which is not strongly related to immunosuppression and may relate to ultraviolet radiation exposure. In contrast, the greatly increased risks for Merkel cell and sebaceous carcinoma suggest an etiologic role for immunosuppression. JF - AIDS AU - Lanoy, E AU - Dores, G M AU - Madeleine, M M AU - Toro, J R AU - Fraumeni, JF Jr AU - Engels, E A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 7076, Rockville, MD 20892, USA, engelse@exchange.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 385 EP - 393 VL - 23 IS - 3 SN - 0269-9370, 0269-9370 KW - Risk Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - demography KW - Acquired immune deficiency syndrome KW - homosexuality KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - Skin cancer KW - Melanoma KW - Demography KW - CD4 antigen KW - U.V. radiation KW - Risk factors KW - Ultraviolet radiation KW - Ethnic groups KW - Skin KW - Data processing KW - melanoma KW - Cancer KW - Carcinoma KW - USA KW - Epidemiology KW - Standards KW - Immunosuppression KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20368472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Epidemiology+of+nonkeratinocytic+skin+cancers+among+persons+with+AIDS+in+the+United+States&rft.au=Lanoy%2C+E%3BDores%2C+G+M%3BMadeleine%2C+M+M%3BToro%2C+J+R%3BFraumeni%2C+JF+Jr%3BEngels%2C+E+A&rft.aulast=Lanoy&rft.aufirst=E&rft.date=2009-01-01&rft.volume=23&rft.issue=3&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0b013e3283213046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Demography; CD4 antigen; Acquired immune deficiency syndrome; Data processing; U.V. radiation; Epidemiology; Risk factors; Skin cancer; Ethnic groups; Immunosuppression; Melanoma; Carcinoma; demography; Skin; Ultraviolet radiation; homosexuality; Standards; melanoma; Cancer; USA; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir DO - http://dx.doi.org/10.1097/QAD.0b013e3283213046 ER - TY - JOUR T1 - DNA polymerase switching: effects on spontaneous mutagenesis in Escherichia coli AN - 20352365; 9019975 AB - SummaryEscherichia coli possesses five known DNA polymerases (pols). Pol III holoenzyme is the cell's main replicase, while pol I is responsible for the maturation of Okazaki fragments and filling gaps generated during nucleotide excision repair. Pols II, IV and V are significantly upregulated as part of the cell's global SOS response to DNA damage and under these conditions, may alter the fidelity of DNA replication by potentially interfering with the ability of pols I and III to complete their cellular functions. To test this hypothesis, we determined the spectrum of rpoB mutations arising in an isogenic set of mutL strains differentially expressing the chromosomally encoded pols. Interestingly, mutagenic hot spots in rpoB were identified that are susceptible to the actions of pols I-V. For example, in a recA730 lexA(Def) mutL background most transversions were dependent upon pols IV and V. In contrast, transitions were largely dependent upon pol I and to a lesser extent, pol III. Furthermore, the extent of pol I-dependent mutagenesis at one particular site was modulated by pols II and IV. Our observations suggest that there is considerable interplay among all five E.coli polymerases that either reduces or enhances the mutagenic load on the E.coli chromosome. JF - Molecular Microbiology AU - Curti, Elena AU - McDonald, John P AU - Mead, Samantha AU - Woodgate, Roger AD - Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD20892-3371, USA. Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 315 EP - 331 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 71 IS - 2 SN - 0950-382X, 0950-382X KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - DNA biosynthesis KW - Replication KW - Transversion KW - replicase KW - Mutagenesis KW - Okazaki fragments KW - DNA damage KW - Chromosomes KW - Fidelity KW - Nucleotide excision repair KW - DNA-directed DNA polymerase KW - SOS response KW - Escherichia coli KW - Mutation KW - RpoB protein KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20352365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=DNA+polymerase+switching%3A+effects+on+spontaneous+mutagenesis+in+Escherichia+coli&rft.au=Curti%2C+Elena%3BMcDonald%2C+John+P%3BMead%2C+Samantha%3BWoodgate%2C+Roger&rft.aulast=Curti&rft.aufirst=Elena&rft.date=2009-01-01&rft.volume=71&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06526.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Replication; replicase; Transversion; Mutagenesis; Okazaki fragments; DNA damage; Fidelity; Chromosomes; Nucleotide excision repair; DNA-directed DNA polymerase; SOS response; Mutation; RpoB protein; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06526.x ER - TY - JOUR T1 - Research paper: Induction of lactoferrin gene expression by innate immune stimuli in mouse mammary epithelial HC-11 cells AN - 20346492; 9011899 AB - Lactoferrin (LF) is a multifunctional protein. While its functions and mechanism of actions are actively being investigated, the cellular signals that regulate LF expression have not been as explored. We have previously demonstrated that LF is upregulated by estrogen in the reproductive system. In this study, we show that the expression of LF was stimulated by bacterial lipopolysaccharide (LPS) and double-stranded RNA (dsRNA) in normal mouse mammalian HC-11 cells. When cells were exposed to either LPS or dsRNA, the mRNA and protein of LF were increased in a dose - and time-dependent manner, yet the kinetics of LF induction by dsRNA or LPS were different. The LPS and dsRNA-induced LF was mainly released into the culture medium where it blocked TNF-a production in exposed cells. We explored the mechanisms of LF induction by LPS and dsRNA using specific inhibitors and found that the induction could be attenuated by inhibitors to PKC, NF-kB, p38 and JNK, but not by an inhibitor to PKA. Interestingly, ERK inhibitor was effective against dsRNA but not against LPS induction of LF. These data suggest that LF was induced by LPS and dsRNA through PKC, NF-kB and MAPK pathways which in turn play an inhibitory role in the continuation of innate inflammation. JF - Biochimie AU - Li, Yin AU - Limmon, Gino V AU - Imani, Farhad AU - Teng, Christina AD - Gene Regulation Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA, teng1@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 58 EP - 67 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 91 IS - 1 SN - 0300-9084, 0300-9084 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Lactoferrin KW - LPS KW - dsRNA KW - HC-11 cells KW - PKC KW - MAPK KW - NF-kB KW - Inhibitors KW - Protein kinase C KW - Protein kinase A KW - MAP kinase KW - Estrogens KW - c-Jun amino-terminal kinase KW - Data processing KW - Double-stranded RNA KW - Cell culture KW - Tumor necrosis factor-a KW - Reproductive system KW - Inflammation KW - Gene expression KW - Extracellular signal-regulated kinase KW - Kinetics KW - lactoferrin KW - NF-B protein KW - Lipopolysaccharides KW - J 02310:Genetics & Taxonomy KW - W 30940:Products KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimie&rft.atitle=Research+paper%3A+Induction+of+lactoferrin+gene+expression+by+innate+immune+stimuli+in+mouse+mammary+epithelial+HC-11+cells&rft.au=Li%2C+Yin%3BLimmon%2C+Gino+V%3BImani%2C+Farhad%3BTeng%2C+Christina&rft.aulast=Li&rft.aufirst=Yin&rft.date=2009-01-01&rft.volume=91&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Biochimie&rft.issn=03009084&rft_id=info:doi/10.1016%2Fj.biochi.2008.04.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Estrogens; MAP kinase; Protein kinase A; Data processing; c-Jun amino-terminal kinase; Double-stranded RNA; Cell culture; Tumor necrosis factor-a; Reproductive system; Inflammation; Gene expression; Extracellular signal-regulated kinase; Kinetics; NF-B protein; lactoferrin; Lipopolysaccharides DO - http://dx.doi.org/10.1016/j.biochi.2008.04.014 ER - TY - JOUR T1 - The impact of primary health care on malaria morbidity - defining access by disease burden AN - 20342072; 9020803 AB - Primary care facilities are increasingly becoming the focal point for distribution of malaria intervention strategies, but physical access to these facilities may limit the extent to which communities can be reached. To investigate the impact of travel time to primary care on the incidence of hospitalized malaria episodes in a rural district in Kenya.MethodsThe incidence of hospitalized malaria in a population under continuous demographic surveillance was recorded over 3years. The time to travel to the nearest primary health care facility was calculated for every child between birth and 5years of age and trends in incidence of hospitalized malaria as a function of travel time were evaluated.ResultsThe incidence of hospitalized malaria more than doubled as travel time to the nearest primary care facility increased from 10min to 2h. Good access to primary health facilities may reduce the burden of disease by as much as 66%.ConclusionsOur results highlight both the potential of the primary health care system in reaching those most at risk and reducing the disease burden. Insufficient access is an important risk factor, one that may be inequitably distributed to the poorest households. JF - Tropical Medicine and International Health AU - O'Meara, W P AU - Noor, A AU - Gatakaa, H AU - Tsofa, B AU - McKenzie, F E AU - Marsh, K AD - 1Fogarty International Center, National Institutes of Health, Bethesda, MD, USA, prudhomw@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 29 EP - 35 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 14 IS - 1 SN - 1360-2276, 1360-2276 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Travel KW - Biological surveys KW - Age KW - Human diseases KW - Autonomic nervous system KW - Parturition KW - Malaria KW - Age determination KW - expressed sequence tags KW - Morbidity KW - Public health KW - Demography KW - Birth KW - Dan protein KW - Risk factors KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20342072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tropical+Medicine+and+International+Health&rft.atitle=The+impact+of+primary+health+care+on+malaria+morbidity+-+defining+access+by+disease+burden&rft.au=O%27Meara%2C+W+P%3BNoor%2C+A%3BGatakaa%2C+H%3BTsofa%2C+B%3BMcKenzie%2C+F+E%3BMarsh%2C+K&rft.aulast=O%27Meara&rft.aufirst=W&rft.date=2009-01-01&rft.volume=14&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Tropical+Medicine+and+International+Health&rft.issn=13602276&rft_id=info:doi/10.1111%2Fj.1365-3156.2008.02194.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Biological surveys; Human diseases; Autonomic nervous system; Parturition; Malaria; Age determination; Public health; Birth; Demography; Travel; Dan protein; Age; Risk factors; expressed sequence tags; Morbidity DO - http://dx.doi.org/10.1111/j.1365-3156.2008.02194.x ER - TY - JOUR T1 - Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources AN - 20340287; 9024154 AB - DAVID bioinformatics resources consists of an integrated biological knowledgebase and analytic tools aimed at systematically extracting biological meaning from large gene/protein lists. This protocol explains how to use DAVID, a high-throughput and integrated data-mining environment, to analyze gene lists derived from high-throughput genomic experiments. The procedure first requires uploading a gene list containing any number of common gene identifiers followed by analysis using one or more text and pathway-mining tools such as gene functional classification, functional annotation chart or clustering and functional annotation table. By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies. JF - Nature Protocols AU - Huang, da Wei AU - Sherman, Brad T AU - Lempicki, Richard A Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 44 EP - 57 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 4 IS - 1 SN - 1754-2189, 1754-2189 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Computational and theoretical biology KW - Genomes KW - Proteins KW - Bioinformatics KW - genomics KW - G 07750:Ecological & Population Genetics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20340287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Systematic+and+integrative+analysis+of+large+gene+lists+using+DAVID+bioinformatics+resources&rft.au=Huang%2C+da+Wei%3BSherman%2C+Brad+T%3BLempicki%2C+Richard+A&rft.aulast=Huang&rft.aufirst=da&rft.date=2009-01-01&rft.volume=4&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.211 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Proteins; genomics; Bioinformatics DO - http://dx.doi.org/10.1038/nprot.2008.211 ER - TY - JOUR T1 - Contributions of the two accessory subunits, RNASEH2B and RNASEH2C, to the activity and properties of the human RNase H2 complex AN - 20338123; 9014656 AB - Eukaryotic RNase H2 is a heterotrimeric enzyme. Here, we show that the biochemical composition and stoichiometry of the human RNase H2 complex is consistent with the properties previously deduced from genetic studies. The catalytic subunit of eukaryotic RNase H2, RNASEH2A, is well conserved and similar to the monomeric prokaryotic RNase HII. In contrast, the RNASEH2B and RNASEH2C subunits from human and Saccharomyces cerevisiae share very little homology, although they both form soluble B/C complexes that may serve as a nucleation site for the addition of RNASEH2A to form an active RNase H2, or for interactions with other proteins to support different functions. The RNASEH2B subunit has a PIP-box and confers PCNA binding to human RNase H2. Unlike Escherichia coli RNase HII, eukaryotic RNase H2 acts processively and hydrolyzes a variety of RNA/DNA hybrids with similar efficiencies, suggesting multiple cellular substrates. Moreover, of five analyzed mutations in human RNASEH2B and RNASEH2C linked to Aicardi-Goutieres Syndrome (AGS), only one, R69W in the RNASEH2C protein, exhibits a significant reduction in specific activity, revealing a role for the C subunit in enzymatic activity. Near-normal activity of four AGS-related mutant enzymes was unexpected in light of their predicted impairment causing the AGS phenotype. JF - Nucleic Acids Research AU - Chon, Hyongi AU - Vassilev, Alex AU - DePamphilis, Melvin L AU - Zhao, Yingming AU - Zhang, Junmei AU - Burgers, Peter M AU - Crouch, Robert J AU - Cerritelli, Susana M AD - 1 Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda MD 20892, 2 Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 and 3 Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA, robert_crouch@nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 96 EP - 110 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 37 IS - 1 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Catalytic subunits KW - Proliferating cell nuclear antigen KW - Saccharomyces cerevisiae KW - Nucleation KW - ribonuclease H2 KW - ribonuclease A KW - Homology KW - RNA KW - Hybrids KW - Escherichia coli KW - DNA KW - ribonuclease G KW - Enzymatic activity KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - K 03310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20338123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Contributions+of+the+two+accessory+subunits%2C+RNASEH2B+and+RNASEH2C%2C+to+the+activity+and+properties+of+the+human+RNase+H2+complex&rft.au=Chon%2C+Hyongi%3BVassilev%2C+Alex%3BDePamphilis%2C+Melvin+L%3BZhao%2C+Yingming%3BZhang%2C+Junmei%3BBurgers%2C+Peter+M%3BCrouch%2C+Robert+J%3BCerritelli%2C+Susana+M&rft.aulast=Chon&rft.aufirst=Hyongi&rft.date=2009-01-01&rft.volume=37&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn913 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nucleation; ribonuclease A; ribonuclease H2; RNA; Homology; Hybrids; DNA; Catalytic subunits; Enzymatic activity; ribonuclease G; Proliferating cell nuclear antigen; Mutation; Escherichia coli; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1093/nar/gkn913 ER - TY - JOUR T1 - Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists AN - 20328986; 9014658 AB - Functional analysis of large gene lists, derived in most cases from emerging high-throughput genomic, proteomic and bioinformatics scanning approaches, is still a challenging and daunting task. The gene-annotation enrichment analysis is a promising high-throughput strategy that increases the likelihood for investigators to identify biological processes most pertinent to their study. Approximately 68 bioinformatics enrichment tools that are currently available in the community are collected in this survey. Tools are uniquely categorized into three major classes, according to their underlying enrichment algorithms. The comprehensive collections, unique tool classifications and associated questions/issues will provide a more comprehensive and up-to-date view regarding the advantages, pitfalls and recent trends in a simpler tool-class level rather than by a tool-by-tool approach. Thus, the survey will help tool designers/developers and experienced end users understand the underlying algorithms and pertinent details of particular tool categories/tools, enabling them to make the best choices for their particular research interests. JF - Nucleic Acids Research AU - Huang, Da Wei AU - Sherman, Brad T AU - Lempicki, Richard A AD - Laboratory of Immunopathogenesis and Bioinformatics, Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA, rlempicki@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 1 EP - 13 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 37 IS - 1 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Scanning KW - Algorithms KW - Bioinformatics KW - proteomics KW - genomics KW - G 07880:Human Genetics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20328986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Bioinformatics+enrichment+tools%3A+paths+toward+the+comprehensive+functional+analysis+of+large+gene+lists&rft.au=Huang%2C+Da+Wei%3BSherman%2C+Brad+T%3BLempicki%2C+Richard+A&rft.aulast=Huang&rft.aufirst=Da&rft.date=2009-01-01&rft.volume=37&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn923 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Scanning; Algorithms; genomics; proteomics; Bioinformatics DO - http://dx.doi.org/10.1093/nar/gkn923 ER - TY - JOUR T1 - Gonadal Transcriptome Alterations in Response to Dietary Energy Intake: Sensing the Reproductive Environment AN - 20306454; 8922505 AB - Reproductive capacity and nutritional input are tightly linked and animals' specific responses to alterations in their physical environment and food availability are crucial to ensuring sustainability of that species. We have assessed how alterations in dietary energy intake (both reductions and excess), as well as in food availability, via intermittent fasting (IF), affect the gonadal transcriptome of both male and female rats. Starting at four months of age, male and female rats were subjected to a 20% or 40% caloric restriction (CR) dietary regime, every other day feeding (IF) or a high fat-high glucose (HFG) diet for six months. The transcriptional activity of the gonadal response to these variations in dietary energy intake was assessed at the individual gene level as well as at the parametric functional level. At the individual gene level, the females showed a higher degree of coherency in gonadal gene alterations to CR than the males. The gonadal transcriptional and hormonal response to IF was also significantly different between the male and female rats. The number of genes significantly regulated by IF in male animals was almost 5 times greater than in the females. These IF males also showed the highest testosterone to estrogen ratio in their plasma. Our data show that at the level of gonadal gene responses, the male rats on the IF regime adapt to their environment in a manner that is expected to increase the probability of eventual fertilization of females that the males predict are likely to be sub-fertile due to their perception of a food deficient environment. JF - PLoS ONE AU - Martin, Bronwen AU - Pearson, Michele AU - Brenneman, Randall AU - Golden, Erin AU - Wood, William AU - Prabhu, Vinayakumar AU - Becker, Kevin G AU - Mattson, Mark P AU - Maudsley, Stuart AU - Dey, Sudhansu Kumar AD - Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House VL - 4 IS - 1 SN - 1932-6203, 1932-6203 KW - Genetics Abstracts; Ecology Abstracts; Sustainability Science Abstracts KW - Age KW - feeding KW - Glucose KW - Energy intake KW - Food availability KW - Fasting KW - Nutrition KW - Rats KW - Gene expression KW - Fertilization KW - sustainability KW - Diets KW - food availability KW - Feeding KW - Estrogens KW - Data processing KW - Dietary restrictions KW - Transcription KW - Testosterone KW - fertilization KW - Perception KW - estrogens KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies KW - G 07750:Ecological & Population Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20306454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Gonadal+Transcriptome+Alterations+in+Response+to+Dietary+Energy+Intake%3A+Sensing+the+Reproductive+Environment&rft.au=Martin%2C+Bronwen%3BPearson%2C+Michele%3BBrenneman%2C+Randall%3BGolden%2C+Erin%3BWood%2C+William%3BPrabhu%2C+Vinayakumar%3BBecker%2C+Kevin+G%3BMattson%2C+Mark+P%3BMaudsley%2C+Stuart%3BDey%2C+Sudhansu+Kumar&rft.aulast=Martin&rft.aufirst=Bronwen&rft.date=2009-01-01&rft.volume=4&rft.issue=1&rft.spage=e4146&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=19326203&rft_id=info:doi/10.1371%2Fjournal.pone.0004146 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Feeding; Age; Estrogens; Data processing; Dietary restrictions; Energy intake; Glucose; Transcription; Food availability; Fasting; Gene expression; Fertilization; Testosterone; Perception; food availability; Rats; Diets; fertilization; feeding; sustainability; Nutrition; estrogens DO - http://dx.doi.org/10.1371/journal.pone.0004146 ER - TY - JOUR T1 - Bone marrow stromal cells attenuate sepsis via prostaglandin E sub(2)- dependent reprogramming of host macrophages to increase their interleukin-10 production AN - 20305369; 8935478 AB - Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed. Administering bone marrow stromal cells (BMSCs-also known as mesenchymal stem cells) to mice before or shortly after inducing sepsis by cecal ligation and puncture reduced mortality and improved organ function. The beneficial effect of BMSCs was eliminated by macrophage depletion or pretreatment with antibodies specific for interleukin-10 (IL-10) or IL-10 receptor. Monocytes and/or macrophages from septic lungs made more IL-10 when prepared from mice treated with BMSCs versus untreated mice. Lipopolysaccharide (LPS)-stimulated macrophages produced more IL-10 when cultured with BMSCs, but this effect was eliminated if the BMSCs lacked the genes encoding Toll-like receptor 4, myeloid differentiation primary response gene-88, tumor necrosis factor (TNF) receptor-1a or cyclooxygenase-2. Our results suggest that BMSCs (activated by LPS or TNF-[alpha]) reprogram macrophages by releasing prostaglandin E sub(2) that acts on the macrophages through the prostaglandin EP2 and EP4 receptors. Because BMSCs have been successfully given to humans and can easily be cultured and might be used without human leukocyte antigen matching, we suggest that cultured, banked human BMSCs may be effective in treating sepsis in high-risk patient groups. JF - Nature Medicine AU - Nemeth, Krisztian AU - Leelahavanichkul, Asada AU - Yuen, Peter S T AU - Mayer, Balazs AU - Parmelee, Alissa AU - Doi, Kent AU - Robey, Pamela G AU - Leelahavanichkul, Kantima AU - Koller, Beverly H AU - Brown, Jared M AU - Hu, Xuzhen AU - Jelinek, Ivett AU - Star, Robert A AU - Mezey, Eva Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 42 EP - 49 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 1 SN - 1078-8956, 1078-8956 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Histocompatibility antigen HLA KW - Cyclooxygenase-2 KW - Mortality KW - stromal cells KW - Tumor necrosis factor KW - Bone marrow KW - Prostaglandin E2 KW - Interleukin 10 KW - Differentiation KW - Sepsis KW - Antibodies KW - Stem cells KW - Lung KW - Lipopolysaccharides KW - Cecum KW - Risk groups KW - Monocytes KW - Mesenchyme KW - TLR4 protein KW - Toll-like receptors KW - G 07720:Immunogenetics KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20305369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Bone+marrow+stromal+cells+attenuate+sepsis+via+prostaglandin+E+sub%282%29-+dependent+reprogramming+of+host+macrophages+to+increase+their+interleukin-10+production&rft.au=Nemeth%2C+Krisztian%3BLeelahavanichkul%2C+Asada%3BYuen%2C+Peter+S+T%3BMayer%2C+Balazs%3BParmelee%2C+Alissa%3BDoi%2C+Kent%3BRobey%2C+Pamela+G%3BLeelahavanichkul%2C+Kantima%3BKoller%2C+Beverly+H%3BBrown%2C+Jared+M%3BHu%2C+Xuzhen%3BJelinek%2C+Ivett%3BStar%2C+Robert+A%3BMezey%2C+Eva&rft.aulast=Nemeth&rft.aufirst=Krisztian&rft.date=2009-01-01&rft.volume=15&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm.1905 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Histocompatibility antigen HLA; Macrophages; Mortality; stromal cells; Tumor necrosis factor; Bone marrow; Prostaglandin E2; Interleukin 10; Differentiation; Stem cells; Antibodies; Sepsis; Lung; Risk groups; Cecum; Lipopolysaccharides; Monocytes; Mesenchyme; TLR4 protein; Toll-like receptors DO - http://dx.doi.org/10.1038/nm.1905 ER - TY - JOUR T1 - A novel signaling pathway impact analysis AN - 20302503; 8921174 AB - Motivation: Gene expression class comparison studies may identify hundreds or thousands of genes as differentially expressed (DE) between sample groups. Gaining biological insight from the result of such experiments can be approached, for instance, by identifying the signaling pathways impacted by the observed changes. Most of the existing pathway analysis methods focus on either the number of DE genes observed in a given pathway (enrichment analysis methods), or on the correlation between the pathway genes and the class of the samples (functional class scoring methods). Both approaches treat the pathways as simple sets of genes, disregarding the complex gene interactions that these pathways are built to describe.Results: We describe a novel signaling pathway impact analysis (SPIA) that combines the evidence obtained from the classical enrichment analysis with a novel type of evidence, which measures the actual perturbation on a given pathway under a given condition. A bootstrap procedure is used to assess the significance of the observed total pathway perturbation. Using simulations we show that the evidence derived from perturbations is independent of the pathway enrichment evidence. This allows us to calculate a global pathway significance P-value, which combines the enrichment and perturbation P-values. We illustrate the capabilities of the novel method on four real datasets. The results obtained on these data show that SPIA has better specificity and more sensitivity than several widely used pathway analysis methods.Availability: SPIA was implemented as an R package available at http://vortex.cs.wayne.edu/ontoexpress/: Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Tarca, Adi Laurentiu AU - Draghici, Sorin AU - Khatri, Purvesh AU - Hassan, Sonia S AU - Mittal, Pooja AU - Kim, Jung-sun AU - Kim, Chong Jai AU - Kusanovic, Juan Pedro AU - Romero, Roberto AD - 1 Department of Computer Science, Wayne State University, 431 State Hall, Detroit, MI 48202 and 2 Perinatology Research Branch-NIH-NICHD, 4 Brush, 3990 John R, Detroit, MI 48201, USA, sorin@wayne.edu Y1 - 2009/01/01/ PY - 2009 DA - 2009 Jan 01 SP - 75 EP - 82 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 25 IS - 1 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - Bioinformatics KW - Signal transduction KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=A+novel+signaling+pathway+impact+analysis&rft.au=Tarca%2C+Adi+Laurentiu%3BDraghici%2C+Sorin%3BKhatri%2C+Purvesh%3BHassan%2C+Sonia+S%3BMittal%2C+Pooja%3BKim%2C+Jung-sun%3BKim%2C+Chong+Jai%3BKusanovic%2C+Juan+Pedro%3BRomero%2C+Roberto&rft.aulast=Tarca&rft.aufirst=Adi&rft.date=2009-01-01&rft.volume=25&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn577 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Bioinformatics; Signal transduction DO - http://dx.doi.org/10.1093/bioinformatics/btn577 ER - TY - JOUR T1 - The National Center for Biotechnology Information's Protein Clusters Database AN - 20301425; 8921564 AB - Rapid increases in DNA sequencing capabilities have led to a vast increase in the data generated from prokaryotic genomic studies, which has been a boon to scientists studying micro-organism evolution and to those who wish to understand the biological underpinnings of microbial systems. The NCBI Protein Clusters Database (ProtClustDB) has been created to efficiently maintain and keep the deluge of data up to date. ProtClustDB contains both curated and uncurated clusters of proteins grouped by sequence similarity. The May 2008 release contains a total of 285 386 clusters derived from over 1.7 million proteins encoded by 3806 nt sequences from the RefSeq collection of complete chromosomes and plasmids from four major groups: prokaryotes, bacteriophages and the mitochondrial and chloroplast organelles. There are 7180 clusters containing 376 513 proteins with curated gene and protein functional annotation. PubMed identifiers and external cross references are collected for all clusters and provide additional information resources. A suite of web tools is available to explore more detailed information, such as multiple alignments, phylogenetic trees and genomic neighborhoods. ProtClustDB provides an efficient method to aggregate gene and protein annotation for researchers and is available at http://www.ncbi.nlm.nih.gov/sites/entrez?db=proteinclusters. JF - Nucleic Acids Research AU - Klimke, William AU - Agarwala, Richa AU - Badretdin, Azat AU - Chetvernin, Slava AU - Ciufo, Stacy AU - Fedorov, Boris AU - Kiryutin, Boris AU - O'Neill, Kathleen AU - Resch, Wolfgang AU - Resenchuk, Sergei AU - Schafer, Susan AU - Tolstoy, Igor AU - Tatusova, Tatiana AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA, klimke@ncbi.nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - D216 EP - D223 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 37 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phylogeny KW - Phages KW - Data processing KW - Mitochondria KW - Chloroplasts KW - Plasmids KW - Databases KW - DNA sequencing KW - Chromosomes KW - Prokaryotes KW - genomics KW - Organelles KW - Evolution KW - Amino acid sequence KW - V 22320:Replication KW - N 14810:Methods KW - G 07760:Viruses & Phages KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+National+Center+for+Biotechnology+Information%27s+Protein+Clusters+Database&rft.au=Klimke%2C+William%3BAgarwala%2C+Richa%3BBadretdin%2C+Azat%3BChetvernin%2C+Slava%3BCiufo%2C+Stacy%3BFedorov%2C+Boris%3BKiryutin%2C+Boris%3BO%27Neill%2C+Kathleen%3BResch%2C+Wolfgang%3BResenchuk%2C+Sergei%3BSchafer%2C+Susan%3BTolstoy%2C+Igor%3BTatusova%2C+Tatiana&rft.aulast=Klimke&rft.aufirst=William&rft.date=2009-01-01&rft.volume=37&rft.issue=suppl_1&rft.spage=D216&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn734 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phages; Phylogeny; Data processing; Mitochondria; Chloroplasts; Plasmids; Databases; Chromosomes; DNA sequencing; genomics; Prokaryotes; Organelles; Evolution; Amino acid sequence DO - http://dx.doi.org/10.1093/nar/gkn734 ER - TY - JOUR T1 - Investigation of the Metabolites of (S, S)-[ super(11)C]MeNER in Humans, Monkeys and Rats AN - 20293630; 8933004 AB - (S,S)-[ super(11)C]MeNER ((S,S)-2-( alpha -(2- [ super(11)C]methoxyphenoxy)benzyl)morpholine) is a positron emission tomography (PET) radioligand recently applied in clinical studies of norepinephrine transporters (NETs) in the human brain in vivo. In view of further assessment of the suitability of (S,S)-[ super(11)C]MeNER as a NET radioligand, its metabolism and the identity of the in vivo radiometabolites of (S,S)-[ super(11)C]MeNER are of great interest. Materials and Methods Thus, PET studies were used to measure brain dynamics of (S,S)-[ super(11)C]MeNER, and plasma reverse-phase radiochromatographic analysis was performed to monitor and quantify its rate of metabolism. Eighteen healthy human volunteers, five cynomolgus monkeys, and five rats were studied. Results and Discussion In human subjects, the plasma radioactivity representing (S,S)-[ super(11)C]MeNER decreased from 88 +/- 5% at 4 min after injection to 82 +/- 7% at 40 min, while a polar radiometabolite increased from 3 +/- 3% to 16 +/- 7% at the same time-points, respectively. A more lipophilic radiometabolite than (S,S)- [ super(11)C]MeNER decreased from 9 +/- 5% at 4 min to 1 +/- 2% at 40 min. In monkeys, plasma radioactivity representing (S,S)-[ super(11)C]MeNER decreased from 97 +/- 2% at 4 min to 74 +/- 7% at 45 min, with a polar fraction as the major radiometabolite. A more lipophilic radiometabolite than (S,S)-[ super(11)C]MeNER, constituted 3 +/- 2% of radioactivity at 4 min and was not detectable later on. In rats, 17 +/- 4% of plasma radioactivity was parent radioligand at 30 min with the remainder comprising mainly a polar radiometabolite. (S,S)-[ super(11)C]MeNER in rat brain and urine at 30 min after injection were 90% and 4%, respectively. On a brain regional level, parent radioligand ranged from 87.5 +/- 3.9% (57.2 +/- 14.2% SUV [standard uptake values, %injected radioactivity per mL multiplied with animal weight (in g)]; cerebellum) to 92.9 +/- 1.8% (36.1 +/- 4.7% SUV; striatum), with differential distribution of the radiometabolite in the cerebellum (6.7 +/- 0.3% SUV) and the striatum (2.5 +/- 0.3% SUV). Liquid chromatography-mass spectrometry analysis of rat urine identified a hydroxylation product of the methoxyphenoxy ring of (S,S)-MeNER as the main metabolite. In the brain, the corresponding main metabolite was the product from O-de- methylation of (S,S)-MeNER. PET measurements were performed in rats as well as in wild-type and P-gp-knock-out mice. In rats, the brain peak level of radioactivity was found to be very low (65%SUV). In mice, there was only a small difference in peak brain accumulation between P-gp knock-out and wild-type mice (145 vs. 125%SUV) with the following rank order of regional brain radioactivity: cerebellum X thalamus > cortical regions > striatum. Conclusion It can be concluded that radiometabolites of (S,S)- [ super(11)C]MeNER are of minor importance in rat and monkey brain imaging. The presence of a transient lipophilic radiometabolite in peripheral human plasma may induce complications with brain imaging, but its kinetics appear favorable in relation to the slow kinetics of (S,S)-[ super(11)C]MeNER in humans. JF - Molecular Imaging and Biology AU - Schou, Magnus AU - Zoghbi, Sami S AU - Shetty, HUmesha AU - Shchukin, Evgeny AU - Liow, Jeih-San AU - Hong, Jinsoo AU - Andree, Bengt A AU - Gulyas, Balazs AU - Farde, Lars AU - Innis, Robert B AU - Pike, Victor W AU - Halldin, Christer AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10 Rm. B3 C346A, 10 Center Drive, Bethesda, MD 20892-1003, USA, magnus.schou@astrazeneca.com Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 23 EP - 30 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 11 IS - 1 SN - 1536-1632, 1536-1632 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Key Words MeNER KW - Metabolism KW - PET KW - Neuroimaging KW - Cerebellum KW - Brain KW - Metabolites KW - Thalamus KW - Lipophilic KW - Spectrometry KW - Hydroxylation KW - Cortex KW - Urine KW - Norepinephrine transporter KW - Kinetics KW - Neostriatum KW - Positron emission tomography KW - Cynomolgus KW - Radioactivity KW - Methylation KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20293630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Imaging+and+Biology&rft.atitle=Investigation+of+the+Metabolites+of+%28S%2C+S%29-%5B+super%2811%29C%5DMeNER+in+Humans%2C+Monkeys+and+Rats&rft.au=Schou%2C+Magnus%3BZoghbi%2C+Sami+S%3BShetty%2C+HUmesha%3BShchukin%2C+Evgeny%3BLiow%2C+Jeih-San%3BHong%2C+Jinsoo%3BAndree%2C+Bengt+A%3BGulyas%2C+Balazs%3BFarde%2C+Lars%3BInnis%2C+Robert+B%3BPike%2C+Victor+W%3BHalldin%2C+Christer&rft.aulast=Schou&rft.aufirst=Magnus&rft.date=2009-01-01&rft.volume=11&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Molecular+Imaging+and+Biology&rft.issn=15361632&rft_id=info:doi/10.1007%2Fs11307-008-0175-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Brain; Cerebellum; Metabolites; Lipophilic; Thalamus; Hydroxylation; Spectrometry; Cortex; Norepinephrine transporter; Urine; Kinetics; Neostriatum; Positron emission tomography; Radioactivity; Methylation; Cynomolgus DO - http://dx.doi.org/10.1007/s11307-008-0175-y ER - TY - JOUR T1 - Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors AN - 20278147; 8935401 AB - Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the [alpha] subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution of the PKR kinase domain in vertebrates, coupled with positive selection of specific sites. Substitution of positively selected residues in human PKR with residues found in related species altered sensitivity to PKR inhibitors from different poxviruses. Species-specific differences in sensitivity to poxviral pseudosubstrate inhibitors were identified between human and mouse PKR, and these differences were traced to positively selected residues near the eIF2[alpha] binding site. Our findings indicate how an antiviral protein evolved to evade viral inhibition while maintaining its primary function. Moreover, the identified species-specific differences in the susceptibility to viral inhibitors have important implications for studying human infections in nonhuman model systems. JF - Nature Structural & Molecular Biology AU - Rothenburg, Stefan AU - Seo, Eun Joo AU - Gibbs, James S AU - Dever, Thomas E AU - Dittmar, Katharina AD - Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA., rothenst@mail.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 63 EP - 70 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 16 IS - 1 SN - 1545-9993, 1545-9993 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - eIF-2 kinase KW - Replication initiation KW - Replication KW - Animal models KW - Protein kinase KW - Initiation factor eIF-2 KW - Infection KW - Positive selection KW - Evolution KW - A 01340:Antibiotics & Antimicrobials KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20278147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Structural+%26+Molecular+Biology&rft.atitle=Rapid+evolution+of+protein+kinase+PKR+alters+sensitivity+to+viral+inhibitors&rft.au=Rothenburg%2C+Stefan%3BSeo%2C+Eun+Joo%3BGibbs%2C+James+S%3BDever%2C+Thomas+E%3BDittmar%2C+Katharina&rft.aulast=Rothenburg&rft.aufirst=Stefan&rft.date=2009-01-01&rft.volume=16&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Nature+Structural+%26+Molecular+Biology&rft.issn=15459993&rft_id=info:doi/10.1038%2Fnsmb.1529 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Replication initiation; eIF-2 kinase; Replication; Animal models; Protein kinase; Initiation factor eIF-2; Positive selection; Infection; Evolution DO - http://dx.doi.org/10.1038/nsmb.1529 ER - TY - JOUR T1 - ATGC: a database of orthologous genes from closely related prokaryotic genomes and a research platform for microevolution of prokaryotes AN - 20274508; 8921472 AB - The database of Alignable Tight Genomic Clusters (ATGCs) consists of closely related genomes of archaea and bacteria, and is a resource for research into prokaryotic microevolution. Construction of a data set with appropriate characteristics is a major hurdle for this type of studies. With the current rate of genome sequencing, it is difficult to follow the progress of the field and to determine which of the available genome sets meet the requirements of a given research project, in particular, with respect to the minimum and maximum levels of similarity between the included genomes. Additionally, extraction of specific content, such as genomic alignments or families of orthologs, from a selected set of genomes is a complicated and time-consuming process. The database addresses these problems by providing an intuitive and efficient web interface to browse precomputed ATGCs, select appropriate ones and access ATGC-derived data such as multiple alignments of orthologous proteins, matrices of pairwise intergenomic distances based on genome-wide analysis of synonymous and nonsynonymous substitution rates and others. The ATGC database will be regularly updated following new releases of the NCBI RefSeq. The database is hosted by the Genomics Division at Lawrence Berkeley National laboratory and is publicly available at http://atgc.lbl.gov JF - Nucleic Acids Research AU - Novichkov, Pavel S AU - Ratnere, Igor AU - Wolf, Yuri I AU - Koonin, Eugene V AU - Dubchak, Inna AD - 1 Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, 2 Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598 and 3 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA, psnovichkov@lbl.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - D448 EP - D454 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 37 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Databases KW - Data processing KW - Archaea KW - genomics KW - Prokaryotes KW - J 02310:Genetics & Taxonomy KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20274508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=ATGC%3A+a+database+of+orthologous+genes+from+closely+related+prokaryotic+genomes+and+a+research+platform+for+microevolution+of+prokaryotes&rft.au=Novichkov%2C+Pavel+S%3BRatnere%2C+Igor%3BWolf%2C+Yuri+I%3BKoonin%2C+Eugene+V%3BDubchak%2C+Inna&rft.aulast=Novichkov&rft.aufirst=Pavel&rft.date=2009-01-01&rft.volume=37&rft.issue=suppl_1&rft.spage=D448&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn684 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Prokaryotes; genomics; Archaea DO - http://dx.doi.org/10.1093/nar/gkn684 ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 20273905; 8921452 AB - In addition to maintaining the GenBank registered nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Utilities, MyNCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link (BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genomes and related tools, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Retroviral Genotyping Tools, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubChem suite of small molecule databases. Augmenting many of the web applications is custom implementation of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. JF - Nucleic Acids Research AU - Sayers, Eric W AU - Barrett, Tanya AU - Benson, Dennis A AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Edgar, Ron AU - Federhen, Scott AU - Feolo, Michael AU - Geer, Lewis Y AU - Helmberg, Wolfgang AU - Kapustin, Yuri AU - Landsman, David AU - Lipman, David J AU - Madden, Thomas L AU - Maglott, Donna R AU - Miller, Vadim AU - Mizrachi, Ilene AU - Ostell, James AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Sequeira, Edwin AU - Sherry, Stephen T AU - Shumway, Martin AU - Sirotkin, Karl AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Yaschenko, Eugene AU - Ye, Jian AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA, sayers@ncbi.nlm.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - D5 EP - D15 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 37 IS - suppl_1 SN - 0305-1048, 0305-1048 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Molecular modelling KW - Data processing KW - Heredity KW - Genotyping KW - DNA probes KW - Cancer KW - Gene expression KW - Computer programs KW - Databases KW - Chromosomes KW - nucleic acids KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Taxonomy KW - Protein interaction KW - V 22360:AIDS and HIV KW - G 07740:Evolution KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20273905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Sayers%2C+Eric+W%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BEdgar%2C+Ron%3BFederhen%2C+Scott%3BFeolo%2C+Michael%3BGeer%2C+Lewis+Y%3BHelmberg%2C+Wolfgang%3BKapustin%2C+Yuri%3BLandsman%2C+David%3BLipman%2C+David+J%3BMadden%2C+Thomas+L%3BMaglott%2C+Donna+R%3BMiller%2C+Vadim%3BMizrachi%2C+Ilene%3BOstell%2C+James%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BSequeira%2C+Edwin%3BSherry%2C+Stephen+T%3BShumway%2C+Martin%3BSirotkin%2C+Karl%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BYaschenko%2C+Eugene%3BYe%2C+Jian&rft.aulast=Sayers&rft.aufirst=Eric&rft.date=2009-01-01&rft.volume=37&rft.issue=suppl_1&rft.spage=D5&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn741 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Molecular modelling; Data processing; Heredity; DNA probes; Genotyping; Cancer; Gene expression; Databases; Computer programs; Chromosomes; nucleic acids; Polymerase chain reaction; Taxonomy; Protein interaction; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1093/nar/gkn741 ER - TY - JOUR T1 - Characterization of liver toxicity in F344/N rats and B6C3F1 mice after exposure to a flame retardant containing lower molecular weight polybrominated diphenyl ethers AN - 20266903; 8853431 AB - Lower molecular weight polybrominated diphenyl ethers (PBDEs), components of flame retardants, are found in the environment and in human and animal tissues. Toxicity studies were conducted in F344/N rats and B6C3F1 mice by administering a flame retardant containing these lower molecular weight PBDEs (BDE-47, BDE-99, BDE-100, and BDE153) by oral gavage 5 days/week for 13 weeks at doses of 0.01, 5, 50, 100 or 500 mg/kg/day. Liver was the primary target organ in rats and mice. Treatment-related increases in liver weights, liver cytochrome P450 (1A1, 1A2, 2B) and UDPGT (rats only) levels, and liver lesions were seen in both rats and mice. Hepatocyte hypertrophy and vacuolization increased in incidence and severity with treatment, and occurred at levels of 50 mg/kg and above in rats, and at 100 mg/kg and above in mice. Liver Cyp 1A1, 1A2, and 2B levels were increased at exposure levels of 50 mg/kg and above in rats and mice. In addition, treatment-related thyroid lesions occurred particularly in rats. The most sensitive parameter for PBDE toxicity was the increase in liver weights which occurred at 5 mg/kg above in rats and 50 mg/kg and above in mice. These results suggest that liver may be a target organ for carcinogenesis processes after long-term administration of PBDEs. A chronic PBDE study is currently being conducted by the National Toxicology Program. JF - Experimental and Toxicologic Pathology AU - Dunnick, June K AU - Nyska, Abraham AD - National Institute of Environmental Health Sciences, Research Triangle Park, P.O. Box 12233, NC 27709, USA, dunnickj@niehs.nih.gov Y1 - 2009/01// PY - 2009 DA - Jan 2009 SP - 1 EP - 12 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 61 IS - 1 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Flame retardant KW - Polybrominated diphenyl ethers KW - Liver toxicity KW - polybrominated diphenyl ethers KW - Hypertrophy KW - Hepatocytes KW - Molecular weight KW - Carcinogenesis KW - Liver KW - Thyroid KW - Fire retardant chemicals KW - Toxicity KW - Cytochrome P450 KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20266903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=Characterization+of+liver+toxicity+in+F344%2FN+rats+and+B6C3F1+mice+after+exposure+to+a+flame+retardant+containing+lower+molecular+weight+polybrominated+diphenyl+ethers&rft.au=Dunnick%2C+June+K%3BNyska%2C+Abraham&rft.aulast=Dunnick&rft.aufirst=June&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2008.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Hypertrophy; polybrominated diphenyl ethers; Hepatocytes; Molecular weight; Carcinogenesis; Thyroid; Liver; Cytochrome P450; Toxicity; Fire retardant chemicals DO - http://dx.doi.org/10.1016/j.etp.2008.06.008 ER - TY - JOUR T1 - Evidence for Translocation of Microbial Products in Patients with Idiopathic CD4 Lymphocytopenia AN - 20187983; 10190598 AB - Translocation of microbial products has been described in chronic human immunodeficiency virus (HIV) infection and correlates with activation of the immune system. We investigated the potential translocation of microbial products in idiopathic CD4 lymphocytopenia (ICL), a rare disorder characterized by low CD4 T cell counts in the absence of HIV infection. Plasma lipopolysaccharide (LPS) levels and T cell activation were measured in a cross-sectional cohort study of patients with ICL and HIV infection and healthy control subjects. Increases in CD4 T cell proliferation but not CD8 T cell proliferation were observed in patients with ICL. LPS levels were significantly elevated both in patients with ICL and in patients with HIV infection, and they were strongly correlated with the proportion of proliferating CD4 T cells in the cohort of patients with ICL ([image] ; [image]). The proportions of T helper (Th) 17 and Th1 CD4 cells in peripheral blood were similar between patients with ICL, patients with HIV infection, and control subjects. These findings suggest a potential association of translocation of microbial products with perturbed CD4 T cell homeostasis in individuals with CD4 lymphopenic states other than HIV infection. JF - Journal of Infectious Diseases AU - Lee, Philip I AU - Ciccone, Emily J AU - Read, Sarah W AU - Asher, Ava AU - Pitts, Robert AU - Douek, Daniel C AU - Brenchley, Jason M AU - Sereti, Irini AD - Laboratory of Immunoregulation, Clinical and Molecular Retrovirology Section, Division of AIDS, Human Immunology Section, Vaccine Research Center, and Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, isereti@niaid.nih.gov Y1 - 2009///0, PY - 2009 DA - 0, 2009 SP - 1664 EP - 1670 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 199 IS - 11 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Helper cells KW - Immune system KW - Lymphopenia KW - Peripheral blood KW - Homeostasis KW - CD8 antigen KW - Cell activation KW - CD4 antigen KW - Human immunodeficiency virus KW - Chronic infection KW - Lymphocytes T KW - Lipopolysaccharides KW - Cell proliferation KW - Translocation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20187983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Evidence+for+Translocation+of+Microbial+Products+in+Patients+with+Idiopathic+CD4+Lymphocytopenia&rft.au=Lee%2C+Philip+I%3BCiccone%2C+Emily+J%3BRead%2C+Sarah+W%3BAsher%2C+Ava%3BPitts%2C+Robert%3BDouek%2C+Daniel+C%3BBrenchley%2C+Jason+M%3BSereti%2C+Irini&rft.aulast=Lee&rft.aufirst=Philip&rft.date=2009-01-01&rft.volume=199&rft.issue=11&rft.spage=1664&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F598953 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Immune system; Helper cells; Lymphopenia; Peripheral blood; CD8 antigen; Homeostasis; Cell activation; CD4 antigen; Chronic infection; Lymphocytes T; Lipopolysaccharides; Cell proliferation; Translocation; Human immunodeficiency virus DO - http://dx.doi.org/10.1086/598953 ER - TY - JOUR T1 - Oral bacterial biofilms - history in progress AN - 20147868; 10262417 JF - Microbiology AU - Palmer, Robert J Y1 - 2009 PY - 2009 DA - 2009 SP - 2113 EP - 2114 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 155 IS - 7 SN - 1350-0872, 1350-0872 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Biofilms KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20147868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Oral+bacterial+biofilms+-+history+in+progress&rft.au=Palmer%2C+Robert+J&rft.aulast=Palmer&rft.aufirst=Robert&rft.date=2009-01-01&rft.volume=155&rft.issue=7&rft.spage=2113&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/10.1099%2Fmic.0.030809-0 L2 - http://mic.sgmjournals.org/cgi/reprint/155/7/2113.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Biofilms; Bacteria DO - http://dx.doi.org/10.1099/mic.0.030809-0 ER - TY - JOUR T1 - Molecular basis for the integration of inositol phosphate signaling pathways via human ITPK1 AN - 20083906; 10095116 JF - Advances in Enzyme Regulation AU - Shears, Stephen B AD - Inositol Signaling Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, NC 27709, USA, shears@niehs.nih.gov Y1 - 2009 PY - 2009 DA - 2009 SP - 87 EP - 96 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 49 IS - 1 SN - 0065-2571, 0065-2571 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - inositol phosphate KW - Enzymes KW - Signal transduction KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20083906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Sex+Differences+in+WISC-III+Profiles+of+Children+with+High-functioning+Pervasive+Developmental+Disorders&rft.au=Koyama%2C+Tomonori%3BKamio%2C+Yoko%3BInada%2C+Naoko%3BKurita%2C+Hiroshi&rft.aulast=Koyama&rft.aufirst=Tomonori&rft.date=2009-01-01&rft.volume=39&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0610-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Integration; inositol phosphate; Enzymes; Signal transduction DO - http://dx.doi.org/10.1016/j.advenzreg.2008.12.008 ER - TY - JOUR T1 - Acute but not Chronic Donepezil Increases Muscarinic Receptor-Mediated Signaling via Arachidonic Acid in Unanesthetized Rats AN - 20073920; 10081595 AB - Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Muscarinic receptors are coupled to cytosolic phospholipase A_{2} (cPLA_{2}) activation and arachidonic acid (AA) release from synaptic membrane phospholipid. This activation can be imaged in rodents as an AA incorporation coefficient k*, using quantitative autoradiography. Acute and chronic effects of donepezil on the AA signal, k* for AA, were measured in 81 brain regions of unanesthetized rats. Twenty min after a single oral dose (3.0 mg/kg) of donepezil, k* was increased significantly in 37 brain regions, whereas k* did not differ from control 7 h afterwards or following chronic (21 days) of donepezil. Pretreatment with atropine prevented the 20-min increments in k* following donepezil. Donepezil also increased the brain ACh concentration and reduced brain AChE activity, but did not change cPLA_{2} activity, regardless of administration regimen. These results show that donepezil acutely increases the brain AA signal that is mediated by ACh acting at muscarinic receptors, but that this signal is rapidly desensitized despite continued elevated brain ACh concentration. In contrast, the AA signal in response to arecoline was not altered following donepezil. JF - Journal of Alzheimer's Disease AU - Basselin, Mireille AU - Nguyen, Henry N AU - Chang, Lisa AU - Bell, Jane M AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 369 EP - 382 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG The Netherlands VL - 17 IS - 2 SN - 1387-2877, 1387-2877 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Phospholipase A2 KW - Acetylcholinesterase KW - Alzheimer's disease KW - Acetylcholine receptors (muscarinic) KW - Brain KW - Arachidonic acid KW - donepezil KW - Acetylcholine receptors KW - Autoradiography KW - Neurodegenerative diseases KW - Synaptic membranes KW - Chronic effects KW - Acetylcholine KW - Phospholipids KW - Signal transduction KW - Atropine KW - X 24310:Pharmaceuticals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20073920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+Disease&rft.atitle=Acute+but+not+Chronic+Donepezil+Increases+Muscarinic+Receptor-Mediated+Signaling+via+Arachidonic+Acid+in+Unanesthetized+Rats&rft.au=Basselin%2C+Mireille%3BNguyen%2C+Henry+N%3BChang%2C+Lisa%3BBell%2C+Jane+M%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2009-01-01&rft.volume=17&rft.issue=2&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Journal+of+Alzheimer%27s+Disease&rft.issn=13872877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Acetylcholinesterase; Phospholipase A2; Acetylcholine receptors (muscarinic); Alzheimer's disease; Brain; Arachidonic acid; donepezil; Autoradiography; Acetylcholine receptors; Neurodegenerative diseases; Synaptic membranes; Chronic effects; Acetylcholine; Atropine; Signal transduction; Phospholipids ER - TY - JOUR T1 - Origins of Stochasticity and Burstiness in High-Dimensional Biochemical Networks AN - 19515792; 8830178 AB - Two major approaches are known in the field of stochastic dynamics of intracellular biochemical networks. The first one places the focus of attention on the fact that many biochemical constituents vitally important for the network functionality may be present only in small quantities within the cell, and therefore the regulatory process is essentially discrete and prone to relatively big fluctuations. The second approach treats the regulatory process as essentially continuous. Complex pseudostochastic behavior in such processes may occur due to multistability and oscillatory motions within limit cycles. In this paper we outline the third scenario of stochasticity in the regulatory process. This scenario is only conceivable in high-dimensional highly nonlinear systems. In particular, we show that burstiness, a well-known phenomenon in the biology of gene expression, is a natural consequence of high dimensionality coupled with high nonlinearity. In mathematical terms, burstiness is associated with heavy-tailed probability distributions of stochastic processes describing the dynamics of the system. We demonstrate how the 'shot' noise originates from purely deterministic behavior of the underlying dynamical system. We conclude that the limiting stochastic process may be accurately approximated by the 'heavy-tailed' generalized Pareto process which is a direct mathematical expression of burstiness. JF - Eurasip Journal on Bioinformatics and Systems Biology AU - Rosenfeld, Simon AD - Division of Cancer Prevention (DCP) National Cancer Institute EPN 3108 6130 Executive Blvd Bethesda MO 20892, rosenfes@mail.nih.gov Y1 - 2009 PY - 2009 DA - 2009 PB - Hindawi Publishing Corporation, P.O. Box 3079 VL - 2009 SN - 1687-4145, 1687-4145 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - Bioinformatics KW - nonlinear systems KW - Stochasticity KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.atitle=Origins+of+Stochasticity+and+Burstiness+in+High-Dimensional+Biochemical+Networks&rft.au=Rosenfeld%2C+Simon&rft.aulast=Rosenfeld&rft.aufirst=Simon&rft.date=2009-01-01&rft.volume=2009&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.issn=16874145&rft_id=info:doi/10.1155%2F2009%2F362309 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Stochasticity; Computer programs; nonlinear systems; Gene expression; Bioinformatics DO - http://dx.doi.org/10.1155/2009/362309 ER - TY - JOUR T1 - Evaluation of random forests performance for genome-wide association studies in the presence of interaction effects AN - 1034820738; 16899279 AB - Random forests (RF) is one of a broad class of machine learning methods that are able to deal with large-scale data without model specification, which makes it an attractive method for genome-wide association studies (GWAS). The performance of RF and other association methods in the presence of interactions was evaluated using the simulated data from Genetic Analysis Workshop 16 Problem 3, with knowledge of the major causative markers, risk factors, and their interactions in the simulated traits. There was good power to detect the environmental risk factors using RF, trend tests, or regression analyses but the power to detect the effects of the causal markers was poor for all methods. The causal marker that had an interactive effect with smoking did show moderate evidence of association in the RF and regression analyses, suggesting that RF may perform well at detecting such interactions in larger, more highly powered datasets. JF - BMC Proceedings AU - Kim, Yoonhee AU - Wojciechowski, Robert AU - Sung, Heejong AU - Mathias, Rasika A AU - Wang, Li AU - Klein, Alison P AU - Lenroot, Rhoshel K AU - Malley, James AU - Bailey-Wilson, Joan E AD - National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA Y1 - 2009 PY - 2009 DA - 2009 SP - 1 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 3 IS - Suppl 7 SN - 1753-6561, 1753-6561 KW - Risk Abstracts KW - Forests KW - Risk factors KW - Smoking KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034820738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Proceedings&rft.atitle=Evaluation+of+random+forests+performance+for+genome-wide+association+studies+in+the+presence+of+interaction+effects&rft.au=Kim%2C+Yoonhee%3BWojciechowski%2C+Robert%3BSung%2C+Heejong%3BMathias%2C+Rasika+A%3BWang%2C+Li%3BKlein%2C+Alison+P%3BLenroot%2C+Rhoshel+K%3BMalley%2C+James%3BBailey-Wilson%2C+Joan+E&rft.aulast=Kim&rft.aufirst=Yoonhee&rft.date=2009-01-01&rft.volume=3&rft.issue=Suppl+7&rft.spage=S64&rft.isbn=&rft.btitle=&rft.title=BMC+Proceedings&rft.issn=17536561&rft_id=info:doi/ L2 - http://www.biomedcentral.com/1753-6561/3/S7/S64 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 11 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Smoking; Risk factors; Forests ER - TY - JOUR T1 - Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. AN - 69932278; 19104039 AB - A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive nuclear factor-kappaB (NF-kappaB) signaling for survival. Small molecule inhibitors of IkappaB kinase beta (IKKbeta), a key regulator of the NF-kappaB pathway, kill ABC DLBCL cells and hold promise for the treatment of this lymphoma type. We conducted an RNA interference genetic screen to investigate potential mechanisms of resistance of ABC DLBCL cells to IKKbeta inhibitors. We screened a library of small hairpin RNAs (shRNAs) targeting 500 protein kinases for shRNAs that would increase the killing of an ABC DLBCL cell line in the presence of a small molecule IKKbeta inhibitor. Two independent shRNAs targeting IKKalpha synergized with the IKKbeta inhibitor to kill three different ABC DLBCL cell lines but were not toxic by themselves. Surprisingly, IKKalpha shRNAs blocked the classical rather than the alternative NF-kappaB pathway in ABC DLBCL cells, as judged by inhibition of IkappaBalpha phosphorylation. IKKalpha shRNA toxicity was reversed by coexpression of wild-type but not kinase inactive forms of IKKalpha, suggesting that IKKalpha may directly phosphorylate IkappaBalpha under conditions of IKKbeta inhibition. In models of physiologic NF-kappaB pathway activation by CARD11 or tumor necrosis factor-alpha, compensatory IKKalpha activity was also observed with IKKbeta inhibition. These results suggest that therapy for ABC DLBCL may be improved by targeting both IKKalpha and IKKbeta, possibly through CARD11 inhibition. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Lam, Lloyd T AU - Davis, R Eric AU - Ngo, Vu N AU - Lenz, Georg AU - Wright, George AU - Xu, Weihong AU - Zhao, Hong AU - Yu, Xin AU - Dang, Lenny AU - Staudt, Louis M AD - Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12/30/ PY - 2008 DA - 2008 Dec 30 SP - 20798 EP - 20803 VL - 105 IS - 52 KW - CARD Signaling Adaptor Proteins KW - 0 KW - NF-kappa B KW - Protein Kinase Inhibitors KW - Tumor Necrosis Factor-alpha KW - I-kappa B Kinase KW - EC 2.7.11.10 KW - CARD11 protein, human KW - EC 4.6.1.2 KW - Guanylate Cyclase KW - Index Medicus KW - Guanylate Cyclase -- metabolism KW - Humans KW - CARD Signaling Adaptor Proteins -- metabolism KW - Jurkat Cells KW - Drug Delivery Systems -- methods KW - Tumor Necrosis Factor-alpha -- metabolism KW - RNA Interference KW - Drug Screening Assays, Antitumor -- methods KW - Phosphorylation -- drug effects KW - I-kappa B Kinase -- metabolism KW - I-kappa B Kinase -- antagonists & inhibitors KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- pharmacology KW - Signal Transduction -- drug effects KW - Lymphoma, Large B-Cell, Diffuse -- enzymology KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69932278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Compensatory+IKKalpha+activation+of+classical+NF-kappaB+signaling+during+IKKbeta+inhibition+identified+by+an+RNA+interference+sensitization+screen.&rft.au=Lam%2C+Lloyd+T%3BDavis%2C+R+Eric%3BNgo%2C+Vu+N%3BLenz%2C+Georg%3BWright%2C+George%3BXu%2C+Weihong%3BZhao%2C+Hong%3BYu%2C+Xin%3BDang%2C+Lenny%3BStaudt%2C+Louis+M&rft.aulast=Lam&rft.aufirst=Lloyd&rft.date=2008-12-30&rft.volume=105&rft.issue=52&rft.spage=20798&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0806491106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2000 Jul 15;165(2):804-12 [10878354] Blood. 2008 Apr 1;111(7):3701-13 [18160665] J Biol Chem. 2000 Aug 25;275(34):25883-91 [10823818] Science. 2000 Sep 1;289(5484):1550-4 [10968790] Mol Cell. 2001 Feb;7(2):401-9 [11239468] Science. 2001 Mar 16;291(5511):2162-5 [11251123] Nature. 2001 Jul 19;412(6844):346-51 [11460167] Science. 2001 Aug 24;293(5534):1495-9 [11520989] Genome Biol. 2001;2(10):RESEARCH0041 [11597333] Cell. 2001 Dec 14;107(6):763-75 [11747812] J Exp Med. 2001 Dec 17;194(12):1861-74 [11748286] Nat Immunol. 2002 Sep;3(9):830-5 [12154356] J Exp Med. 2002 Sep 16;196(6):743-52 [12235208] Nat Immunol. 2002 Oct;3(10):958-65 [12352969] EMBO J. 2002 Oct 15;21(20):5375-85 [12374738] J Immunol. 2003 May 1;170(9):4630-7 [12707341] Nature. 2003 Jun 5;423(6940):659-63 [12789343] Nat Rev Drug Discov. 2004 Jan;3(1):17-26 [14708018] Mol Cell. 2004 May 7;14(3):289-301 [15125833] Mol Cell. 2004 Aug 27;15(4):535-48 [15327770] Immunity. 2004 Oct;21(4):477-89 [15485626] Cell. 1997 Oct 17;91(2):243-52 [9346241] Science. 1998 Aug 28;281(5381):1360-3 [9721103] Science. 1999 Apr 9;284(5412):309-13 [10195894] Science. 1999 Apr 9;284(5412):321-5 [10195897] Clin Cancer Res. 2005 Jan 1;11(1):28-40 [15671525] Adv Immunol. 2005;87:163-208 [16102574] J Exp Med. 2005 Nov 21;202(10):1423-31 [16301747] Immunity. 2005 Dec;23(6):561-74 [16356855] Immunity. 2005 Dec;23(6):575-85 [16356856] Nature. 2006 May 4;441(7089):106-10 [16572121] J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001 [16525037] Blood. 2006 Jun 1;107(11):4266-73 [16439676] Mol Cell. 2006 Jul 7;23(1):13-23 [16818229] Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):908-13 [17213322] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6359-64 [17404218] Cancer Cell. 2007 Aug;12(2):115-30 [17692804] Cell. 2007 Sep 7;130(5):918-31 [17803913] Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3503-8 [18292232] Science. 2008 Mar 21;319(5870):1676-9 [18323416] Genes Dev. 2000 Jul 15;14(14):1729-33 [10898787] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0806491106 ER - TY - JOUR T1 - Analysis on conservation of disulphide bonds and their structural features in homologous protein domain families. AN - 66650840; 19111067 AB - Disulphide bridges are well known to play key roles in stability, folding and functions of proteins. Introduction or deletion of disulphides by site-directed mutagenesis have produced varying effects on stability and folding depending upon the protein and location of disulphide in the 3-D structure. Given the lack of complete understanding it is worthwhile to learn from an analysis of extent of conservation of disulphides in homologous proteins. We have also addressed the question of what structural interactions replaces a disulphide in a homologue in another homologue. Using a dataset involving 34,752 pairwise comparisons of homologous protein domains corresponding to 300 protein domain families of known 3-D structures, we provide a comprehensive analysis of extent of conservation of disulphide bridges and their structural features. We report that only 54% of all the disulphide bonds compared between the homologous pairs are conserved, even if, a small fraction of the non-conserved disulphides do include cytoplasmic proteins. Also, only about one fourth of the distinct disulphides are conserved in all the members in protein families. We note that while conservation of disulphide is common in many families, disulphide bond mutations are quite prevalent. Interestingly, we note that there is no clear relationship between sequence identity between two homologous proteins and disulphide bond conservation. Our analysis on structural features at the sites where cysteines forming disulphide in one homologue are replaced by non-Cys residues show that the elimination of a disulphide in a homologue need not always result in stabilizing interactions between equivalent residues. We observe that in the homologous proteins, disulphide bonds are conserved only to a modest extent. Very interestingly, we note that extent of conservation of disulphide in homologous proteins is unrelated to the overall sequence identity between homologues. The non-conserved disulphides are often associated with variable structural features that were recruited to be associated with differentiation or specialisation of protein function. JF - BMC structural biology AU - Thangudu, Ratna R AU - Manoharan, Malini AU - Srinivasan, N AU - Cadet, Frédéric AU - Sowdhamini, R AU - Offmann, Bernard AD - Laboratoire de Biochimie et Génétique Moléculaire, Université de La Réunion, BP 7151, 15 avenue René Cassin, 97715 Saint Denis Messag Cedex 09, La Réunion, France. thangudr@ncbi.nlm.nih.gov Y1 - 2008/12/26/ PY - 2008 DA - 2008 Dec 26 SP - 55 VL - 8 KW - Disulfides KW - 0 KW - Proteins KW - Solvents KW - Cystine KW - 48TCX9A1VT KW - Index Medicus KW - Cystine -- chemistry KW - Solvents -- chemistry KW - Sequence Alignment KW - Conserved Sequence KW - Databases, Protein KW - Protein Structure, Tertiary KW - Protein Conformation KW - Structural Homology, Protein KW - Disulfides -- chemistry KW - Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66650840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+structural+biology&rft.atitle=Analysis+on+conservation+of+disulphide+bonds+and+their+structural+features+in+homologous+protein+domain+families.&rft.au=Thangudu%2C+Ratna+R%3BManoharan%2C+Malini%3BSrinivasan%2C+N%3BCadet%2C+Fr%C3%A9d%C3%A9ric%3BSowdhamini%2C+R%3BOffmann%2C+Bernard&rft.aulast=Thangudu&rft.aufirst=Ratna&rft.date=2008-12-26&rft.volume=8&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=BMC+structural+biology&rft.issn=1472-6807&rft_id=info:doi/10.1186%2F1472-6807-8-55 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-16 N1 - Date created - 2009-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Eng. 2002 Dec;15(12):951-3 [12601133] Protein Eng. 2003 Mar;16(3):187-93 [12702798] Proteins. 2003 Oct 1;53(1):1-5 [12945044] Annu Rev Biochem. 2003;72:111-35 [12524212] J Mol Biol. 2004 Jan 23;335(4):1083-92 [14698301] Biol Chem. 2003 Dec;384(12):1553-63 [14719797] J Biol Chem. 2004 Mar 5;279(10):9298-305 [14613939] Bioinformatics. 2004 Mar 22;20(5):653-9 [15033872] Biochem Biophys Res Commun. 2004 May 21;318(1):142-7 [15110765] Proteins. 2004 Jun 1;55(4):1036-42 [15146500] Trends Biochem Sci. 1989 Jul;14(7):304-9 [2672455] Protein Eng. 1989 Nov;3(2):95-103 [2594728] Protein Eng. 1990 Jul;3(7):591-8 [1699222] Protein Eng. 1990 Aug;3(8):667-72 [2217140] Proteomics. 2004 Jun;4(6):1665-71 [15174135] Protein Eng Des Sel. 2004 Apr;17(4):367-73 [15166311] J Mol Biol. 1971 Feb 14;55(3):379-400 [5551392] Nature. 1976 Jun 17;261(5561):552-8 [934293] Adv Protein Chem. 1981;34:167-339 [7020376] Adv Protein Chem. 1981;34:61-92 [6266231] J Mol Biol. 1981 Sep 15;151(2):261-87 [7338898] J Biochem. 1983 Sep;94(3):997-1007 [6643433] Biopolymers. 1983 Dec;22(12):2577-637 [6667333] Biochemistry. 1985 Mar 12;24(6):1501-9 [3986190] Bioessays. 1988 Feb-Mar;8(2):57-63 [3282505] Science. 1989 Feb 10;243(4892):792-4 [2916125] Protein Eng. 1988 Sep;2(3):193-9 [3237684] Protein Eng. 1988 Jul;2(2):119-25 [3244694] J Mol Biol. 1999 Dec 10;294(4):1027-40 [10588904] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] EMBO J. 2000 Jan 17;19(2):164-73 [10637221] J Mol Biol. 2000 Jan 28;295(4):903-14 [10656799] J Mol Biol. 2000 Mar 17;297(1):233-49 [10704319] Biochemistry. 2000 Apr 18;39(15):4207-16 [10757967] Chem Pharm Bull (Tokyo). 2000 Apr;48(4):480-5 [10783065] Bioinformatics. 2000 Mar;16(3):251-6 [10869018] J Mol Biol. 2000 Jul 21;300(4):975-85 [10891282] J Mol Biol. 2000 Jul 21;300(4):1005-16 [10891285] J Mol Biol. 2000 Aug 11;301(2):433-50 [10926519] J Biomol NMR. 2000 Oct;18(2):165-71 [11101221] Protein Sci. 2000 Oct;9(10):1889-97 [11106161] Structure. 2000 Dec 15;8(12):1267-78 [11188691] Protein Sci. 2000 Dec;9(12):2394-404 [11206061] J Mol Biol. 2001 Mar 23;307(2):671-81 [11254389] Cell. 2001 Apr 6;105(1):103-13 [11301006] Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20 [11331761] J Mol Biol. 2001 Jul 13;310(3):617-34 [11439028] Biochemistry. 2001 Aug 7;40(31):9059-64 [11478871] Bioinformatics. 2001 Aug;17(8):721-8 [11524373] Nat Struct Biol. 2001 Sep;8(9):770-4 [11524679] Structure. 2001 Apr 4;9(4):331-40 [11525170] Bioinformatics. 2001 Oct;17(10):957-64 [11673241] Proteins. 2002 Feb 15;46(3):243-9 [11835499] Protein Eng. 2002 Jan;15(1):59-64 [11842239] Methods Enzymol. 2002;353:10-21 [12078485] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9679-84 [12107280] Protein Sci. 2002 Nov;11(11):2735-9 [12381855] Bioinformatics. 2003 Jan 22;19(2):313-4 [12538266] J Bacteriol. 1991 Dec;173(23):7719-22 [1938970] Methods Enzymol. 1991;202:336-56 [1784181] FEBS Lett. 1992 May 11;302(2):117-20 [1633841] Proteins. 1992 Oct;14(2):309-23 [1409577] Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):597-604 [8224474] Protein Sci. 1993 Oct;2(10):1551-8 [8251931] Protein Sci. 1994 Jan;3(1):92-102 [8142902] J Mol Biol. 1994 Apr 22;238(1):54-61 [8145256] Biochem Mol Biol Int. 1994 Aug;33(6):1049-53 [7804129] J Mol Biol. 1995 Apr 7;247(4):536-40 [7723011] Protein Sci. 1995 Nov;4(11):2405-10 [8563638] J Mol Biol. 1996 Jun 14;259(3):480-501 [8676383] Biochemistry. 1996 Aug 13;35(32):10328-38 [8756688] J Mol Biol. 1996 Dec 6;264(3):603-23 [8969308] Proteins. 1997 Mar;27(3):360-6 [9094738] J Biol Chem. 1997 Jun 20;272(25):15661-7 [9188456] J Mol Biol. 1997 Oct 3;272(4):597-612 [9325115] Biochemistry. 1998 Feb 3;37(5):1292-301 [9477955] Biochemistry. 1998 Sep 29;37(39):13475-85 [9753433] Structure. 1998 Sep 15;6(9):1195-206 [9753698] J Mol Biol. 1998 Oct 30;283(3):657-68 [9784374] J Mol Biol. 1998 Dec 4;284(3):541-8 [9826496] Cell. 1999 Feb 5;96(3):341-52 [10025400] Trends Biochem Sci. 1999 Jan;24(1):34-6 [10087920] Biochem Biophys Res Commun. 1999 Apr 13;257(2):418-24 [10198229] Proteins. 1999 Aug 15;36(3):340-6 [10409827] Proteins. 2005 Mar 1;58(4):866-79 [15645448] J Mol Biol. 2005 Apr 1;347(3):565-81 [15755451] J Biol Chem. 2005 Mar 25;280(12):11387-94 [15642731] Bioinformatics. 2005 Apr 15;21(8):1415-20 [15585533] Bioinformatics. 2005 May 15;21(10):2336-46 [15741247] Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W230-2 [15980459] Proteins. 2005 Nov 15;61(3):535-44 [16184609] Bioinformatics. 2005 Dec 15;21(24):4416-9 [16223789] Proteins. 2007 May 1;67(2):255-61 [17285632] Extremophiles. 2008 Jan;12(1):29-38 [17508126] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1472-6807-8-55 ER - TY - JOUR T1 - Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). AN - 69921605; 19053756 AB - Here, we examine the significance that stereochemistry plays within the clinically relevant Janus kinase 3 (Jak3) inhibitor 1 (CP-690,550). A synthesis of all four enantiopure stereoisomers of the drug was carried out and an examination of each compound revealed that only the enantiopure 3R,4R isomer was capable of blocking Stat5 phosphorylation (Jak3 dependent). Each compound was profiled across a panel of over 350 kinases, which revealed a high level of selectivity for the Jak family kinases for these related compounds. Each stereoisomer retained a degree of binding to Jak3 and Jak2 and the 3R,4S and 3S,4R stereoisomers were further revealed to have binding affinity for selected members of the STE7 and STE20 subfamily of kinases. Finally, an appraisal of the minimum energy conformation of each stereoisomer and molecular docking at Jak3 was performed in an effort to better understand each compounds selectivity and potency profiles. JF - Journal of medicinal chemistry AU - Jiang, Jian-kang AU - Ghoreschi, Kamran AU - Deflorian, Francesca AU - Chen, Zhi AU - Perreira, Melissa AU - Pesu, Marko AU - Smith, Jeremy AU - Nguyen, Dac-Trung AU - Liu, Eric H AU - Leister, William AU - Costanzi, Stefano AU - O'Shea, John J AU - Thomas, Craig J AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, USA. Y1 - 2008/12/25/ PY - 2008 DA - 2008 Dec 25 SP - 8012 EP - 8018 VL - 51 IS - 24 KW - Piperidines KW - 0 KW - Protein Kinase Inhibitors KW - Pyrimidines KW - Pyrroles KW - tofacitinib KW - 87LA6FU830 KW - JAK2 protein, human KW - EC 2.7.10.2 KW - Janus Kinase 2 KW - Index Medicus KW - Stereoisomerism KW - Models, Molecular KW - Kinetics KW - Humans KW - Models, Chemical KW - Molecular Conformation KW - Inhibitory Concentration 50 KW - Monte Carlo Method KW - Janus Kinase 2 -- chemistry KW - Protein Binding KW - Hydrogen Bonding KW - Drug Design KW - Pyrimidines -- chemical synthesis KW - Protein Kinase Inhibitors -- pharmacology KW - Pyrimidines -- pharmacology KW - Protein Kinase Inhibitors -- chemical synthesis KW - Chemistry, Pharmaceutical -- methods KW - Pyrroles -- pharmacology KW - Pyrroles -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69921605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Examining+the+chirality%2C+conformation+and+selective+kinase+inhibition+of+3-%28%283R%2C4R%29-4-methyl-3-%28methyl%287H-pyrrolo%5B2%2C3-d%5Dpyrimidin-4-yl%29amino%29piperidin-1-yl%29-3-oxopropanenitrile+%28CP-690%2C550%29.&rft.au=Jiang%2C+Jian-kang%3BGhoreschi%2C+Kamran%3BDeflorian%2C+Francesca%3BChen%2C+Zhi%3BPerreira%2C+Melissa%3BPesu%2C+Marko%3BSmith%2C+Jeremy%3BNguyen%2C+Dac-Trung%3BLiu%2C+Eric+H%3BLeister%2C+William%3BCostanzi%2C+Stefano%3BO%27Shea%2C+John+J%3BThomas%2C+Craig+J&rft.aulast=Jiang&rft.aufirst=Jian-kang&rft.date=2008-12-25&rft.volume=51&rft.issue=24&rft.spage=8012&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm801142b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-12-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Rheumatol. 2005 May;17(3):305-11 [15838241] Blood. 2005 Aug 1;106(3):996-1002 [15831699] Blood. 2006 Jan 1;107(1):176-83 [16174768] Nat Immunol. 2007 Jan;8(1):25-30 [17179969] Nat Biotechnol. 2008 Jan;26(1):127-32 [18183025] Blood. 2008 Feb 15;111(4):2155-7 [18094329] Expert Opin Ther Targets. 2004 Dec;8(6):613-29 [15584866] J Exp Med. 1995 Jan 1;181(1):399-404 [7528775] Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7307-11 [7638186] Science. 1995 Nov 3;270(5237):794-7 [7481767] Science. 1995 Nov 3;270(5237):797-800 [7481768] Cell. 1998 May 1;93(3):397-409 [9590174] Genome Biol. 2004;5(12):253 [15575979] Science. 2003 Oct 31;302(5646):875-8 [14593182] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm801142b ER - TY - JOUR T1 - Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities. AN - 69907921; 19053760 AB - A number of bis(diazeniumdiolates) that we designed to release up to 4 mol of nitric oxide (NO) and that are structural analogues of the NO prodrug and anticancer lead compound O(2)-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino)diazen-1-ium-1,2- diolate (PABA/NO) were synthesized and studied. A majority of these compounds yielded higher levels of NO, were better inhibitors of proliferation of a number of cancer cell lines, and more rapidly induced substantially increased levels of S-glutathionylation of cellular proteins in comparison with PABA/NO. In most cases, the antiproliferative activity and extents of S-glutathionylation correlated well with levels of intracellular NO release. We report bis(diazeniumdiolates) to be a class of S-glutathionylating agents with potent antiproliferative and S-glutathionylating activity. JF - Journal of medicinal chemistry AU - Andrei, Daniela AU - Maciag, Anna E AU - Chakrapani, Harinath AU - Citro, Michael L AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. dandrei@dom.edu Y1 - 2008/12/25/ PY - 2008 DA - 2008 Dec 25 SP - 7944 EP - 7952 VL - 51 IS - 24 KW - Azo Compounds KW - 0 KW - Nitric Oxide Donors KW - Prodrugs KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Prodrugs -- chemistry KW - HL-60 Cells KW - Humans KW - Nitric Oxide -- chemistry KW - Models, Chemical KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Chemistry, Pharmaceutical -- methods KW - Cell Proliferation KW - Drug Design KW - Nitric Oxide Donors -- chemistry KW - Azo Compounds -- chemistry KW - Glutathione -- chemistry KW - Azo Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69907921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Aryl+bis%28diazeniumdiolates%29%3A+potent+inducers+of+S-glutathionylation+of+cellular+proteins+and+their+in+vitro+antiproliferative+activities.&rft.au=Andrei%2C+Daniela%3BMaciag%2C+Anna+E%3BChakrapani%2C+Harinath%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Andrei&rft.aufirst=Daniela&rft.date=2008-12-25&rft.volume=51&rft.issue=24&rft.spage=7944&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm800831y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-22 N1 - Date created - 2008-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Adv Enzymol Relat Areas Mol Biol. 1994;69:1-44 [7817866] Blood. 1992 Oct 15;80(8):1880-4 [1382708] Leuk Res. 1995 Aug;19(8):527-33 [7658698] Methods Enzymol. 1996;268:281-93 [8782594] Chem Res Toxicol. 1997 Jan;10(1):2-18 [9074797] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] Leukemia. 1998 Sep;12(9):1461-6 [9737697] Expert Opin Investig Drugs. 2005 Jul;14(7):835-46 [16022573] Curr Top Med Chem. 2005;5(7):597-601 [16101422] Curr Top Med Chem. 2005;5(7):625-36 [16101424] Mol Pharmacol. 2006 Feb;69(2):501-8 [16288082] J Med Chem. 2006 Feb 9;49(3):1157-64 [16451080] J Med Chem. 2006 Jul 13;49(14):4356-66 [16821795] Leuk Res. 2006 Oct;30(10):1279-83 [16439016] Drug Resist Updat. 2006 Jun;9(3):157-73 [16822706] Biochem Pharmacol. 2007 May 1;73(9):1257-69 [17098212] Cardiovasc Res. 2007 Jul 15;75(2):220-8 [17451659] Blood. 2007 Jul 15;110(2):709-18 [17384201] Org Lett. 2007 Aug 16;9(17):3409-12 [17658755] Free Radic Biol Med. 2007 Sep 15;43(6):883-98 [17697933] Curr Opin Pharmacol. 2007 Aug;7(4):398-403 [17611156] Curr Opin Pharmacol. 2007 Aug;7(4):381-91 [17662654] Org Lett. 2007 Oct 25;9(22):4551-4 [17918856] Bioorg Med Chem Lett. 2008 Feb 1;18(3):950-3 [18178089] Bioorg Med Chem. 2008 Mar 1;16(5):2657-64 [18060792] Antioxid Redox Signal. 2008 Mar;10(3):445-73 [18092936] J Cardiovasc Pharmacol. 1999 Dec;34(6):879-86 [10598133] J Org Chem. 2001 May 4;66(9):3090-8 [11325274] J Biol Chem. 2001 Dec 21;276(51):47763-6 [11684673] Mol Cancer Ther. 2003 Apr;2(4):409-17 [12700285] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5103-6 [12697895] J Cell Physiol. 2003 Dec;197(3):426-34 [14566972] Mol Pharmacol. 2004 May;65(5):1070-9 [15102935] Mol Cancer Ther. 2004 Jun;3(6):709-14 [15210857] J Cell Mol Med. 2004 Apr-Jun;8(2):201-12 [15256068] Free Radic Biol Med. 2004 Sep 15;37(6):735-6 [15304248] Biochem Pharmacol. 1988 Jul 1;37(13):2495-501 [3291879] Pharmacol Rev. 1991 Jun;43(2):109-42 [1852778] Chem Res Toxicol. 1991 Mar-Apr;4(2):131-40 [1782341] Blood. 1995 Aug 1;86(3):1184-95 [7542498] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800831y ER - TY - JOUR T1 - Application of binocular vision technology in anterior cruciate ligament surgical navigation system AN - 20478579; 9175818 AB - Based on the failed surgery due to great drilling location errors in rebuilding the knee anterior cruciate ligament, a method was introduced with binocular stereo vision technology rational planning and C-armed X-ray. A new idea that adopts the gridiron pattern marker to simplify the stereo matching process was presented in the self-developed binocular vision positioning system. The calibrated system detected the distance between the pairs of markers which were within 1.5 m distance from the binocular vision sensing units, and the error was less than 1 mm. The application in the anterior cruciate ligament reconstruction surgery shows that the system is stable, reliable, cost-effective, easy-to-calibrate, with sufficient accuracy and high positioning precision, and can meet the requirements of surgical navigation. JF - Journal of Clinical Rehabilitative Tissue Engineering Research AU - Jin-Bing, X AU - Lei, H AU - Peng-Wei, Z AD - Department of Computer, Inner Mongolia Medical College, Hohhot 010059, Nei Monggol Autonomous Region, China, xiejinbing@immc.edu.cn Y1 - 2008/12/23/ PY - 2008 DA - 2008 Dec 23 SP - 10297 EP - 10300 PB - Publishing House of Journal of Clinical Rehabilitative Tissue Engineering Research VL - 12 IS - 52 SN - 1673-8225, 1673-8225 KW - Biotechnology and Bioengineering Abstracts KW - Reconstruction KW - Vision KW - Surgery KW - Ionizing radiation KW - Drilling KW - anterior cruciate ligament KW - Tissue engineering KW - Knee KW - Binocular vision KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20478579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.atitle=Application+of+binocular+vision+technology+in+anterior+cruciate+ligament+surgical+navigation+system&rft.au=Jin-Bing%2C+X%3BLei%2C+H%3BPeng-Wei%2C+Z&rft.aulast=Jin-Bing&rft.aufirst=X&rft.date=2008-12-23&rft.volume=12&rft.issue=52&rft.spage=10297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Rehabilitative+Tissue+Engineering+Research&rft.issn=16738225&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Reconstruction; Vision; Ionizing radiation; Surgery; Drilling; anterior cruciate ligament; Tissue engineering; Knee; Binocular vision ER - TY - JOUR T1 - Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples. AN - 66674524; 19094236 AB - Dependences on addictive substances are substantially-heritable complex disorders whose molecular genetic bases have been partially elucidated by studies that have largely focused on research volunteers, including those recruited in Baltimore. Maryland. Subjects recruited from the Baltimore site of the Epidemiological Catchment Area (ECA) study provide a potentially-useful comparison group for possible confounding features that might arise from selecting research volunteer samples of substance dependent and control individuals. We now report novel SNP (single nucleotide polymorphism) genome wide association (GWA) results for vulnerability to substance dependence in ECA participants, who were initially ascertained as members of a probability sample from Baltimore, and compare the results to those from ethnically-matched Baltimore research volunteers. We identify substantial overlap between the home address zip codes reported by members of these two samples. We find overlapping clusters of SNPs whose allele frequencies differ with nominal significance between substance dependent vs control individuals in both samples. These overlapping clusters of nominally-positive SNPs identify 172 genes in ways that are never found by chance in Monte Carlo simulation studies. Comparison with data from human expressed sequence tags suggests that these genes are expressed in brain, especially in hippocampus and amygdala, to extents that are greater than chance. The convergent results from these probability sample and research volunteer sample datasets support prior genome wide association results. They fail to support the idea that large portions of the molecular genetic results for vulnerability to substance dependence derive from factors that are limited to research volunteers. JF - BMC medical genetics AU - Johnson, Catherine AU - Drgon, Tomas AU - Liu, Qing-Rong AU - Zhang, Ping-Wu AU - Walther, Donna AU - Li, Chuan-Yun AU - Anthony, James C AU - Ding, Yulan AU - Eaton, William W AU - Uhl, George R AD - Molecular Neurobiology Branch, NIH-IRP (NIDA), Suite 3510, 333 Cassell Drive Baltimore, Maryland 21224, USA. johnsoncat@intra.nida.nih.gov Y1 - 2008/12/18/ PY - 2008 DA - 2008 Dec 18 SP - 113 VL - 9 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Alleles KW - Gene Frequency KW - Humans KW - European Continental Ancestry Group KW - Case-Control Studies KW - Baltimore -- epidemiology KW - Male KW - Female KW - Genome, Human KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66674524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+medical+genetics&rft.atitle=Genome+wide+association+for+substance+dependence%3A+convergent+results+from+epidemiologic+and+research+volunteer+samples.&rft.au=Johnson%2C+Catherine%3BDrgon%2C+Tomas%3BLiu%2C+Qing-Rong%3BZhang%2C+Ping-Wu%3BWalther%2C+Donna%3BLi%2C+Chuan-Yun%3BAnthony%2C+James+C%3BDing%2C+Yulan%3BEaton%2C+William+W%3BUhl%2C+George+R&rft.aulast=Johnson&rft.aufirst=Catherine&rft.date=2008-12-18&rft.volume=9&rft.issue=&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=BMC+medical+genetics&rft.issn=1471-2350&rft_id=info:doi/10.1186%2F1471-2350-9-113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-13 N1 - Date created - 2009-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Behav Med. 1989 Apr;12(2):159-82 [2668531] Nucleic Acids Res. 2009 Jan;37(Database issue):D251-60 [18790807] Control Clin Trials. 1990 Apr;11(2):116-28 [2161310] Br J Addict. 1991 Sep;86(9):1119-27 [1932883] Arch Gen Psychiatry. 1992 Sep;49(9):723-7 [1355337] JAMA. 1995 Dec 13;274(22):1786-92 [7500511] Biol Psychiatry. 1996 Oct 15;40(8):776-84 [8894071] Arch Gen Psychiatry. 2000 Mar;57(3):217-22 [10711906] Arch Gen Psychiatry. 2000 Mar;57(3):261-9 [10711912] Am J Med Genet. 2000 Oct 9;96(5):665-70 [11054775] Am J Hum Genet. 2001 Dec;69(6):1290-300 [11704927] JAMA. 2001 Nov 14;286(18):2315-21 [11710898] JAMA. 2001 Nov 14;286(18):2326-8 [11710901] Genet Med. 2003 Jan-Feb;5(1):35-42 [12544474] Nicotine Tob Res. 2004 Jun;6(3):439-46 [15203777] Addict Behav. 1978;3(3-4):235-41 [735910] Am J Epidemiol. 1979 Apr;109(4):394-9 [443238] J Chronic Dis. 1979;32(9-10):633-8 [489703] Arch Gen Psychiatry. 1981 Apr;38(4):381-9 [6260053] J Chronic Dis. 1983;36(10):725-8 [6630408] Arch Gen Psychiatry. 1984 Oct;41(10):934-41 [6089692] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Control Clin Trials. 1998 Dec;19(6):589-601 [9875838] Cancer Epidemiol Biomarkers Prev. 1999 Apr;8(4 Pt 2):369-75 [10207642] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] J Gen Intern Med. 1999 Sep;14(9):537-46 [10491242] Psychol Med. 2004 Oct;34(7):1239-50 [15697050] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9 [16091475] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53 [16894614] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):918-25 [17099884] Hum Mol Genet. 2007 Jan 1;16(1):24-35 [17158188] BMC Genet. 2007;8:10 [17407593] Biochem Pharmacol. 2008 Jan 1;75(1):98-111 [17764662] Arch Gen Psychiatry. 2008 Mar;65(3):345-55 [18316681] Arch Gen Psychiatry. 2008 Jun;65(6):683-93 [18519826] Ann N Y Acad Sci. 2008 Oct;1141:318-81 [18991966] Am J Epidemiol. 1989 Dec;130(6):1088-100 [2589302] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1471-2350-9-113 ER - TY - JOUR T1 - Age-Related Crossover in Breast Cancer Incidence Rates Between Black and White Ethnic Groups AN - 20301201; 8921345 AB - Background Although breast cancer incidence is higher in black women than in white women among women younger than 40 years, the reverse is true among those aged 40 years or older. This crossover in incidence rates between black and white ethnic groups has been well described, has not been completely understood, and has been viewed as an artifact.Methods To quantify this incidence rate crossover, we examined data for 440653 women with invasive breast cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results database from January 1, 1975, through December 31, 2004. Data on invasive female breast cancers were stratified by race, age at diagnosis, year of diagnosis, and tumor characteristics. Standard descriptive analyses were supplemented with Poisson regression models, age-period-cohort models, and two-component mixture models. All statistical tests were two-sided.Results We observed qualitative (ie, crossing or reversing) interactions between age and race. That is, age-specific incidence rates overall (expressed as number of breast cancers per 100000 woman-years) were higher among black women (15.5) than among white women (13.1) younger than 40 years (difference = 2.4, 95% confidence interval [CI] = 2.4 to 2.4), and then, age-specific rates crossed with rates higher among white women (281.3) than among black women (239.5) aged 40 years or older (difference = 41.8, 95% CI = 41.7 to 41.9). The black-to-white incidence rate crossover was observed for all tumor characteristics assessed, although the crossover occurred at earlier ages of diagnosis for low-risk tumor characteristics than for high-risk tumor characteristics. The incidence rate crossover between ethnic groups was robust (ie, reliable and reproducible) to adjustment for calendar period and birth cohort effects in age-period-cohort models (P [Lt] .001 for difference by race).Conclusion Although this ecologic study cannot determine the individual-level factors responsible for the racial crossover in vital rates, it confirms that the age-related crossover in breast cancer incidence rates between black and white ethnic groups is a robust age-specific effect that is independent of period and cohort effects. JF - Journal of the National Cancer Institute AU - Anderson, William F AU - Rosenberg, Philip S AU - Menashe, Idan AU - Mitani, Aya AU - Pfeiffer, Ruth M AD - Affiliations of authors: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, United States Department of Health and Human Services, Bethesda, MD (WFA, PSR, IM, RMP); Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT (AM), wanderso@mail.nih.gov Y1 - 2008/12/17/ PY - 2008 DA - 2008 Dec 17 SP - 1804 EP - 1814 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 24 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Age KW - Breast cancer KW - tumors KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Age-Related+Crossover+in+Breast+Cancer+Incidence+Rates+Between+Black+and+White+Ethnic+Groups&rft.au=Anderson%2C+William+F%3BRosenberg%2C+Philip+S%3BMenashe%2C+Idan%3BMitani%2C+Aya%3BPfeiffer%2C+Ruth+M&rft.aulast=Anderson&rft.aufirst=William&rft.date=2008-12-17&rft.volume=100&rft.issue=24&rft.spage=1804&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn411 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Breast cancer; tumors; Ethnic groups; Cancer DO - http://dx.doi.org/10.1093/jnci/djn411 ER - TY - JOUR T1 - Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies. AN - 69900391; 19057013 AB - Previous studies have shown that a dominant negative form of c-Jun (TAM67) suppresses mouse skin carcinogenesis both in vitro and in vivo. The current study identifies Sulfiredoxin (Srx) as a unique target of activator protein-1 (AP-1) activation and TAM67 inhibition. Manipulation of Srx levels by ShRNA or over-expression demonstrates that Srx is critical for redox homeostasis through reducing hyperoxidized peroxiredoxins. In JB6 cells, knockdown of Srx abolishes tumor promoter-induced transformation and enhances cell sensitivity to oxidative stress. Knockdown of Srx also impairs c-Jun phosphorylation, implicating a role for Srx in the feedback regulation of AP-1 activity. Screening of patient tissues by tissue microarray reveals elevated Srx expression in several types of human skin cancers. Our study indicates that Srx is a functionally significant target of AP-1 blockade that may have value in cancer prevention or treatment. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Wei, Qiou AU - Jiang, Hong AU - Matthews, Connie P AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2008/12/16/ PY - 2008 DA - 2008 Dec 16 SP - 19738 EP - 19743 VL - 105 IS - 50 KW - Peptide Fragments KW - 0 KW - Peroxides KW - Proto-Oncogene Proteins c-jun KW - RNA, Small Interfering KW - TAM67 peptide KW - Transcription Factor AP-1 KW - Oxidoreductases KW - EC 1.- KW - Oxidoreductases Acting on Sulfur Group Donors KW - EC 1.8.- KW - SRXN1 protein, human KW - EC 1.8.98.2 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Animals KW - Cysteine -- metabolism KW - Peroxides -- metabolism KW - Apoptosis KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Epidermis -- metabolism KW - RNA, Small Interfering -- genetics KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Mice KW - Promoter Regions, Genetic KW - Gene Knockdown Techniques KW - Phosphorylation KW - Oxidative Stress KW - Epidermis -- pathology KW - Skin Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic KW - Oxidoreductases -- genetics KW - Cell Transformation, Neoplastic -- pathology KW - Transcription Factor AP-1 -- metabolism KW - Skin Neoplasms -- pathology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69900391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Sulfiredoxin+is+an+AP-1+target+gene+that+is+required+for+transformation+and+shows+elevated+expression+in+human+skin+malignancies.&rft.au=Wei%2C+Qiou%3BJiang%2C+Hong%3BMatthews%2C+Connie+P%3BColburn%2C+Nancy+H&rft.aulast=Wei&rft.aufirst=Qiou&rft.date=2008-12-16&rft.volume=105&rft.issue=50&rft.spage=19738&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/10.1073%2Fpnas.0810676105 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-12 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9827-32 [10449779] Science. 1989 May 5;244(4904):566-9 [2541502] J Biol Chem. 2005 Feb 4;280(5):3125-8 [15590625] Nature. 2005 May 19;435(7040):347-53 [15902258] J Biol Chem. 2005 Jun 17;280(24):23319-27 [15824112] J Invest Dermatol. 2000 Dec;115(6):1108-14 [11121149] J Biol Chem. 2002 Nov 8;277(45):43175-84 [12196529] Dev Cell. 2003 Jun;4(6):879-89 [12791272] Nature. 2003 Jul 31;424(6948):561-5 [12891360] Nature. 2003 Oct 30;425(6961):980-4 [14586471] Nature. 1991 Aug 15;352(6336):635-8 [1907719] J Biol Chem. 1993 May 25;268(15):11050-6 [8496166] Genes Dev. 1993 Jul;7(7B):1309-17 [8330736] Nature. 1993 Sep 9;365(6442):179-81 [8371760] Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):609-13 [8290571] Cancer Res. 1994 Mar 1;54(5):1139-44 [8118794] Mol Carcinog. 1994 Nov;11(3):164-9 [7945805] Science. 1994 Dec 9;266(5191):1719-23 [7992057] Cell. 1995 Sep 8;82(5):721-32 [7545543] FEBS Lett. 1998 Feb 13;423(1):39-44 [9506838] Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8875-80 [15956211] J Biol Chem. 2005 Aug 5;280(31):28775-84 [15941719] Oncogene. 2005 Dec 1;24(54):8038-50 [16170382] Trends Mol Med. 2005 Dec;11(12):571-8 [16290020] J Biol Chem. 2006 May 19;281(20):14400-7 [16565085] Cancer Res. 2006 Jul 1;66(13):6800-6 [16818657] Cancer Res. 2006 Jul 15;66(14):7136-42 [16849559] Plant J. 2007 Feb;49(3):505-14 [17217469] Cancer Res. 2007 Mar 15;67(6):2430-8 [17363560] Carcinogenesis. 2007 Nov;28(11):2382-90 [17566060] Nature. 2008 Jan 3;451(7174):98-101 [18172504] Biochem J. 2008 Apr 1;411(1):191-9 [18052930] Oncogene. 2008 Aug 21;27(36):4877-87 [18454177] Cancer Prev Res (Phila). 2008 Jun;1(1):45-55 [19138935] J Biol Chem. 2004 Jan 23;279(4):2535-43 [14597634] Nat Biotechnol. 2004 Mar;22(3):326-30 [14758366] Cell. 2004 May 28;117(5):625-35 [15163410] Cell. 1974 Dec;3(4):355-9 [4442124] Cancer Res. 1978 Mar;38(3):624-34 [626967] Cell. 1987 Jun 19;49(6):741-52 [3034433] Cell. 1988 Dec 2;55(5):875-85 [3142689] J Biol Chem. 2004 Dec 3;279(49):50994-1001 [15448164] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1073/pnas.0810676105 ER - TY - JOUR T1 - Antitumor Activity of G3139 Lipid Nanoparticles (LNPs) AN - 754551124; 13305289 AB - G3139, an antisense oligodeoxyribonucleotide (ODN) against Bcl-2, contains two CpG dinucleotides and has shown immunostimulatory activities in preclinical studies. It has been suggested that immunoactivation, rather than antisense activity, is primarily responsible for the therapeutic efficacy of G3139. Nanoparticle formulations naturally target phagocytic antigen presenting cells and therefore might enhance the immunological effects of G3139. In this study, a novel formulation of lipid nanoparticles (LNPs) encapsulating G3139 was synthesized and evaluated in mice bearing L1210 subcutaneous tumors. Intravenous injection of G3139-LNPs into mice led to increased serum levels of IL-6 and IFN-*g, promoted proliferation of natural killer (NK) cells and dendritic cells (DCs), and triggered a strong antitumor immune response in mice. The observed effects were much greater than those induced by free G3139. Correspondingly, the G3139-LNPs more effectively inhibited tumor growth and induced complete tumor regression in some mice. In contrast, free G3139 was ineffective in tumor growth inhibition and did not prolong survival of the tumor-bearing mice. These results suggest that G3139-LNPs are a potential immunomodulatory agent and may have applications in cancer therapy. JF - Molecular Pharmaceutics AU - Pan, Xiaogang AU - Chen, Li AU - Liu, Shujun AU - Yang, Xiaojuan AU - Gao, Jian-Xin AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, NSF Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), Department of Pathology, Department of Internal Medicine, College of Medicine and Public Health, and NCI Comprehensive Cancer Center (CCC), The Ohio State University, Columbus, Ohio 43210 Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 211 EP - 220 PB - American Chemical Society VL - 6 IS - 1 SN - 1543-8384, 1543-8384 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Intravenous administration KW - Lipids KW - Natural killer cells KW - Survival KW - CpG islands KW - Tumors KW - Immunomodulation KW - Oligonucleotides KW - Cancer KW - Serum levels KW - Antisense oligonucleotides KW - Dendritic cells KW - Antisense KW - Phagocytes KW - Immunostimulation KW - Antigen-presenting cells KW - Bcl-2 protein KW - Cell proliferation KW - nanoparticles KW - Antitumor activity KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754551124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Antitumor+Activity+of+G3139+Lipid+Nanoparticles+%28LNPs%29&rft.au=Pan%2C+Xiaogang%3BChen%2C+Li%3BLiu%2C+Shujun%3BYang%2C+Xiaojuan%3BGao%2C+Jian-Xin%3BLee%2C+Robert+J&rft.aulast=Pan&rft.aufirst=Xiaogang&rft.date=2008-12-15&rft.volume=6&rft.issue=1&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp800146j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Intravenous administration; Lipids; Natural killer cells; Survival; Tumors; CpG islands; Oligonucleotides; Immunomodulation; Cancer; Serum levels; Dendritic cells; Antisense oligonucleotides; Antisense; Phagocytes; Immunostimulation; Bcl-2 protein; Antigen-presenting cells; Cell proliferation; nanoparticles; Antitumor activity DO - http://dx.doi.org/10.1021/mp800146j ER - TY - JOUR T1 - Transferrin Receptor-Targeted Lipid Nanoparticles for Delivery of an Antisense Oligodeoxyribonucleotide against Bcl-2 AN - 754549980; 13305290 AB - Antisense oligonucleotide G3139-mediated down-regulation of Bcl-2 is a potential strategy for overcoming chemoresistance in leukemia. However, the limited efficacy shown in recent clinical trials calls attention to the need for further development of novel and more efficient delivery systems. In order to address this issue, transferrin receptor (TfR)-targeted, protamine-containing lipid nanoparticles (Tf-LNs) were synthesized as delivery vehicles for G3139. The LNs were produced by an ethanol dilution method, and lipid-conjugated Tf ligand was then incorporated by a postinsertion method. The resulting Tf-LNs had a mean particle diameter of 90 nm and G3139 loading efficiency of 90.4%. Antisense delivery efficiency of Tf-LNs was evaluated in K562, MV4-11, and Raji leukemia cell lines. The results showed that Tf-LNs were more effective than nontargeted LNs and free G3139 (p < 0.05) in decreasing Bcl-2 expression (by up to 62% at the mRNA level in K562 cells) and in inducing caspase-dependent apoptosis. In addition, Bcl-2 down-regulation and apoptosis induced by Tf-LN G3139 were shown to be blocked by excess free Tf and thus were TfR-dependent. Cell lines with higher TfR expression also showed greater Bcl-2 down-regulation. Furthermore, up-regulation of TfR expression in leukemia cells by iron chelator deferoxamine resulted in a further increase in antisense effect (up to 79% Bcl-2 reduction in K562 at the mRNA level) and in caspase-dependent apoptosis (by 3-fold) by Tf-LN. Tf-LN-mediated delivery combined with TfR up-regulation by deferoxamine appears to be a potentially promising strategy for enhancing the delivery efficiency and therapeutic efficacy of antisense oligonucleotides. JF - Molecular Pharmaceutics AU - Yang, Xiaojuan AU - Koh, Chee Guan AU - Liu, Shujun AU - Pan, Xiaogang AU - Santhanam, Ramasamy AU - Yu, Bo AU - Peng, Yong AU - Pang, Jiuxia AU - Golan, Sharon AU - Talmon, Yeshayahu AU - Jin, Yan AU - Muthusamy, Natarajan AU - Byrd, John C AU - Chan, Kenneth K AU - Lee, L James AU - Marcucci, Guido AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, NSF Nanoscale Science and Engineering Center (NSEC) for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), Department of Chemical and Biomolecular Engineering, NCI Comprehensive Cancer Center (CCC), Department of Molecular and Cellular Biochemistry, and Division of Hematology and Oncology, The Ohio State University, Columbus, Ohio 43210, and Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 221 EP - 230 PB - American Chemical Society VL - 6 IS - 1 SN - 1543-8384, 1543-8384 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Lipids KW - Chemoresistance KW - Chelating agents KW - Clinical trials KW - mRNA KW - Antisense oligonucleotides KW - Tumor cell lines KW - Transferrin KW - Transferrin receptors KW - Bcl-2 protein KW - Iron KW - nanoparticles KW - Deferoxamine KW - Ethanol KW - W 30915:Pharmaceuticals & Vaccines KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754549980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmaceutics&rft.atitle=Transferrin+Receptor-Targeted+Lipid+Nanoparticles+for+Delivery+of+an+Antisense+Oligodeoxyribonucleotide+against+Bcl-2&rft.au=Yang%2C+Xiaojuan%3BKoh%2C+Chee+Guan%3BLiu%2C+Shujun%3BPan%2C+Xiaogang%3BSanthanam%2C+Ramasamy%3BYu%2C+Bo%3BPeng%2C+Yong%3BPang%2C+Jiuxia%3BGolan%2C+Sharon%3BTalmon%2C+Yeshayahu%3BJin%2C+Yan%3BMuthusamy%2C+Natarajan%3BByrd%2C+John+C%3BChan%2C+Kenneth+K%3BLee%2C+L+James%3BMarcucci%2C+Guido%3BLee%2C+Robert+J&rft.aulast=Yang&rft.aufirst=Xiaojuan&rft.date=2008-12-15&rft.volume=6&rft.issue=1&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmaceutics&rft.issn=15438384&rft_id=info:doi/10.1021%2Fmp800149s LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Apoptosis; Chemoresistance; Lipids; Chelating agents; Clinical trials; mRNA; Antisense oligonucleotides; Transferrin; Tumor cell lines; Transferrin receptors; Bcl-2 protein; nanoparticles; Iron; Deferoxamine; Ethanol DO - http://dx.doi.org/10.1021/mp800149s ER - TY - JOUR T1 - 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. AN - 69894588; 18785202 AB - 15-LOX-1 and its metabolites are involved in colorectal cancer. Recently, we reported that 15-LOX-1 overexpression in HCT-116 human colorectal cancer cells inhibited cell growth by induction of p53 phosphorylation (4). To determine whether the 15-LOX-1 protein or its metabolites are responsible for phosphorylation of p53 in HCT-116 cells, we used HCT-116 cells that expressed a mutant 15-LOX-1. The mutant 15-LOX-1 enzyme, with a substitution of Leu at residue His361, was devoid of enzymatic activity. HCT-116 cells transiently transfected with either native or mutant 15-LOX-1 showed an increase in p53 phosphorylation and an increase in the expression of downstream genes. Thus, 15-LOX-1 induces p53 phosphorylation independent of enzymatic activity. Treatment of A549 human lung carcinoma cells with IL-4 increased the expression of 15-LOX-1 and also increased the expression of downstream targets of p53. This confirmed that the activation of p53 was also observed in wild-type cells expressing physiological 15-LOX-1. Immunoprecipitation experiments revealed that 15-LOX-1 interacts with, and binds to, DNA-dependent protein kinase (DNA-PK). The binding of 15-LOX-1 to DNA-PK caused an approximate 3.0-fold enhancement in kinase activity, resulting in increased p53 phosphorylation at Ser15. Knockdown of DNA-PK by small interfering RNA (siRNA) significantly reduced p53 phosphorylation. Furthermore, confocal microscopy demonstrated a colocalization of 15-LOX and DNA-PK in the cells. We propose that the 15-LOX-1 protein binds to DNA-PK, increasing its kinase activity and results in downstream activation of the tumor suppressor p53, thus revealing a new mechanism by which lipoxygenases (LOX) may influence the phenotype of tumor cells. (c) 2008 Wiley-Liss, Inc. JF - International journal of cancer AU - Zhu, Hong AU - Glasgow, Wayne AU - George, Margaret D AU - Chrysovergis, Kali AU - Olden, Kenneth AU - Roberts, John D AU - Eling, Thomas AD - Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 2741 EP - 2749 VL - 123 IS - 12 KW - RNA, Small Interfering KW - 0 KW - Tumor Suppressor Protein p53 KW - DNA KW - 9007-49-2 KW - Linoleic Acid KW - 9KJL21T0QJ KW - Arachidonate 15-Lipoxygenase KW - EC 1.13.11.33 KW - Protein Kinases KW - EC 2.7.- KW - Index Medicus KW - Phenotype KW - Gene Expression Regulation, Neoplastic KW - Blotting, Western KW - Phosphorylation KW - Linoleic Acid -- metabolism KW - Transfection KW - Humans KW - DNA -- metabolism KW - Protein Kinases -- genetics KW - Immunoprecipitation KW - HCT116 Cells KW - Fluorescent Antibody Technique KW - Lung Neoplasms -- enzymology KW - Arachidonate 15-Lipoxygenase -- metabolism KW - Colorectal Neoplasms -- metabolism KW - Colorectal Neoplasms -- enzymology KW - Tumor Suppressor Protein p53 -- metabolism KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69894588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=15-lipoxygenase-1+activates+tumor+suppressor+p53+independent+of+enzymatic+activity.&rft.au=Zhu%2C+Hong%3BGlasgow%2C+Wayne%3BGeorge%2C+Margaret+D%3BChrysovergis%2C+Kali%3BOlden%2C+Kenneth%3BRoberts%2C+John+D%3BEling%2C+Thomas&rft.aulast=Zhu&rft.aufirst=Hong&rft.date=2008-12-15&rft.volume=123&rft.issue=12&rft.spage=2741&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.23855 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prostaglandins Leukot Essent Fatty Acids. 2001 Apr-May;64(4-5):217-25 [11418015] J Biol Chem. 2002 Jul 26;277(30):27360-6 [12004065] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9968-73 [12909723] J Immunol. 2003 Jan 15;170(2):887-94 [12517954] J Biol Chem. 2004 Jul 9;279(28):29023-30 [15123652] Immunol Rev. 2004 Aug;200:132-41 [15242401] J Biol Chem. 1990 Mar 25;265(9):5113-20 [2318885] Mol Cell Biol. 1992 Nov;12(11):5041-9 [1406679] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6148-52 [9177185] Cell. 1997 Oct 31;91(3):325-34 [9363941] Int J Biochem Cell Biol. 1997 Jul;29(7):935-8 [9375373] Nat Struct Biol. 1997 Dec;4(12):1003-9 [9406550] Blood. 1998 Jan 1;91(1):64-74 [9414270] J Biol Chem. 1998 Aug 21;273(34):21569-77 [9705287] Science. 1998 Sep 11;281(5383):1677-9 [9733515] Cancer Res. 1998 Oct 1;58(19):4375-82 [9766667] Genes Dev. 1999 Jan 15;13(2):152-7 [9925639] Carcinogenesis. 1999 Oct;20(10):1985-95 [10506115] Biochemistry. 2004 Dec 7;43(48):15296-302 [15568822] Neoplasia. 2004 Nov-Dec;6(6):821-30 [15720809] Ann Surg. 2005 Jun;241(6):941-6; discussion 946-7 [15912043] Mol Cancer Res. 2005 Sep;3(9):511-7 [16179498] J Biol Chem. 2006 Jan 13;281(2):1196-204 [16251187] Oncogene. 2006 Feb 23;25(8):1225-41 [16288226] Neoplasia. 2006 Jun;8(6):510-22 [16820097] Nat Rev Cancer. 2006 Dec;6(12):909-23 [17128209] Biochim Biophys Acta. 2006 Dec;1761(12):1498-505 [17052953] Exp Cell Res. 2006 Dec 10;312(20):4056-69 [17056038] Curr Drug Metab. 2006 Dec;7(8):853-72 [17168687] J Gastroenterol Hepatol. 2007 Dec;22(12):2324-9 [17559385] Biochemistry. 2000 Mar 28;39(12):3185-91 [10727209] Int J Cancer. 2000 Jul 1;87(1):37-43 [10861450] J Natl Cancer Inst. 2000 Jul 19;92(14):1136-42 [10904086] J Biol Chem. 2001 May 11;276(19):16520-7 [11297527] Science. 2001 Jun 15;292(5524):2083-6 [11408659] Prostaglandins Leukot Essent Fatty Acids. 2004 Jan;70(1):7-15 [14643174] J Biol Chem. 2004 Jan 30;279(5):3717-25 [14594811] Methods Mol Biol. 2004;284:1-14 [15173605] Carcinogenesis. 2001 Nov;22(11):1765-73 [11698337] Curr Urol Rep. 2002 Jun;3(3):207-14 [12084190] Carcinogenesis. 2003 Feb;24(2):243-7 [12584173] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.23855 ER - TY - JOUR T1 - Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus). AN - 69870302; 18848574 AB - Alkaloid profiles in skin of poison frogs/toads (Dendrobatidae, Mantellidae, Bufonidae, and Myobatrachidae) are highly dependent on diet and hence on the nature of habitat. Extracts of the two species of toads (Melanophryniscus klappenbachi and Melanophryniscus cupreuscapularis) from similar habitats in the Corrientes/Chaco Provinces of Argentina have similar profiles of alkaloids, which differ considerably in profiles from other Melanophryniscus species from Brazil, Uruguay and Argentina. Structures of two major alkaloids 239Q (1) and 275I (2) were determined by mass, FTIR, and NMR spectral analysis as 5Z,9Z-3-(1-hydroxybutyl)-5-propylindolizidine and 6Z,10E-4,6-di(pent-4-enyl) quinolizidine, respectively. A third alkaloid, 249F (3), is postulated to be a homopumiliotoxin with an unprecedented conjugated exocyclic diene moiety. JF - Toxicon : official journal of the International Society on Toxinology AU - Daly, John W AU - Garraffo, H Martin AU - Spande, Thomas F AU - Yeh, Herman J C AU - Peltzer, Paola M AU - Cacivio, Pedro M AU - Baldo, J Diego AU - Faivovich, Julián AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 858 EP - 870 VL - 52 IS - 8 SN - 0041-0101, 0041-0101 KW - Alkaloids KW - 0 KW - Indolizidines KW - Quinolizidines KW - Index Medicus KW - Molecular Structure KW - Gastrointestinal Contents -- chemistry KW - Spectroscopy, Fourier Transform Infrared KW - Animals KW - Alkaloids -- chemistry KW - Argentina KW - Nuclear Magnetic Resonance, Biomolecular KW - Gas Chromatography-Mass Spectrometry KW - Alkaloids -- isolation & purification KW - Alkaloids -- analysis KW - Indolizidines -- chemistry KW - Skin -- chemistry KW - Bufonidae -- metabolism KW - Quinolizidines -- chemistry KW - Quinolizidines -- analysis KW - Indolizidines -- isolation & purification KW - Indolizidines -- analysis KW - Quinolizidines -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69870302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Indolizidine+239Q+and+quinolizidine+275I.+Major+alkaloids+in+two+Argentinian+bufonid+toads+%28Melanophryniscus%29.&rft.au=Daly%2C+John+W%3BGarraffo%2C+H+Martin%3BSpande%2C+Thomas+F%3BYeh%2C+Herman+J+C%3BPeltzer%2C+Paola+M%3BCacivio%2C+Pedro+M%3BBaldo%2C+J+Diego%3BFaivovich%2C+Juli%C3%A1n&rft.aulast=Daly&rft.aufirst=John&rft.date=2008-12-15&rft.volume=52&rft.issue=8&rft.spage=858&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2008.08.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-12 N1 - Date created - 2008-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicon. 2005 Nov;46(6):641-50 [16157358] J Nat Prod. 2005 Oct;68(10):1556-75 [16252926] J Chem Ecol. 2006 Apr;32(4):795-814 [16718571] Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jan;144(4):398-402 [17208052] J Nat Prod. 2007 Feb;70(2):160-8 [17243727] J Chem Ecol. 2007 Apr;33(4):871-87 [17333373] Proc Natl Acad Sci U S A. 2007 May 22;104(21):8885-90 [17502597] Toxicon. 2007 Nov;50(6):757-78 [17706737] Toxicon. 1978;16(2):163-88 [635931] J Nat Prod. 2002 Apr;65(4):439-47 [11975476] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13996-4001 [12381780] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11092-7 [12960405] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12792-7 [14555763] Mol Phylogenet Evol. 2004 May;31(2):462-75 [15062788] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4346-51 [15070720] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8045-50 [15128938] J Nat Prod. 2004 Aug;67(8):1211-5 [15332834] Science. 1967 May 19;156(3777):970-3 [6023266] Syst Zool. 1967 Dec;16(4):328-42 [6064273] J Am Chem Soc. 1969 Jul 2;91(14):3931-8 [5814950] Experientia. 1971 May 15;27(5):506 [5132572] J Chem Ecol. 2005 Oct;31(10):2403-15 [16195851] Am Nat. 2005 Jan;165(1):56-69 [15729640] Toxicon. 2004 Dec 15;44(8):805-15 [15530960] Science. 1975 Jul 11;189(4197):151-2 [1138374] J Morphol. 1998 Jul;237(1):19-32 [9642789] Toxicon. 1997 May;35(5):705-9 [9203295] Toxicon. 1995 Feb;33(2):246-9 [7597728] Toxicon. 1994 Mar;32(3):279-85 [8016850] J Nat Prod. 1993 Mar;56(3):357-73 [8482947] Steroids. 1986 Sep-Oct;48(3-4):251-7 [3127947] Chem Pharm Bull (Tokyo). 1986 Aug;34(8):3454-7 [3791519] Toxicon. 1984;22(6):905-19 [6523513] Chem Pharm Bull (Tokyo). 1980 May;28(5):1559-62 [7408047] Science. 1980 May 2;208(4443):503-5 [6245447] Nat Prod Rep. 1998 Aug;15(4):397-413 [9736996] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxicon.2008.08.016 ER - TY - JOUR T1 - A validated gas chromatographic-electron impact ionization mass spectrometric method for methamphetamine, methylenedioxymethamphetamine (MDMA), and metabolites in mouse plasma and brain. AN - 69845804; 19026602 AB - A method was developed and fully validated for simultaneous quantification of methamphetamine (MAMP), amphetamine, hydroxy-methamphetamine, methylenedioxymethamphetamine (MDMA, ecstasy), methylenedioxyamphetamine, 3-hydroxy-4-methoxy-methamphetamine, and 3-hydroxy-4-methoxy-amphetamine in 100 microL mouse plasma and 7.5mg brain. Solid phase extraction and gas chromatography-electron impact ionization mass spectrometry in selected-ion monitoring mode achieved plasma linear ranges of 10-20 to 20,000 ng/mL and 0.1-0.2 to 200 ng/mg in brain. Recoveries were greater than 91%, bias 92.3-110.4%, and imprecision less than 5.3% coefficient of variation. This method was used for measuring MAMP and MDMA and metabolites in plasma and brain during mouse neurotoxicity studies. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Scheidweiler, Karl B AU - Barnes, Allan J AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 266 EP - 276 VL - 876 IS - 2 SN - 1570-0232, 1570-0232 KW - Methamphetamine KW - 44RAL3456C KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Humans KW - Brain Chemistry KW - Mice KW - Hydrolysis KW - Male KW - Spectrometry, Mass, Electrospray Ionization -- methods KW - Gas Chromatography-Mass Spectrometry -- methods KW - N-Methyl-3,4-methylenedioxyamphetamine -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- blood KW - Methamphetamine -- blood KW - Methamphetamine -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- analysis KW - Methamphetamine -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69845804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=A+validated+gas+chromatographic-electron+impact+ionization+mass+spectrometric+method+for+methamphetamine%2C+methylenedioxymethamphetamine+%28MDMA%29%2C+and+metabolites+in+mouse+plasma+and+brain.&rft.au=Scheidweiler%2C+Karl+B%3BBarnes%2C+Allan+J%3BHuestis%2C+Marilyn+A&rft.aulast=Scheidweiler&rft.aufirst=Karl&rft.date=2008-12-15&rft.volume=876&rft.issue=2&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=15700232&rft_id=info:doi/10.1016%2Fj.jchromb.2008.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 1997 Dec;19(6):1285-96 [9427251] J Pharmacol Exp Ther. 1998 Mar;284(3):1040-7 [9495865] Mol Pharmacol. 1998 Apr;53(4):649-55 [9547354] J Chromatogr B Biomed Sci Appl. 1999 Feb 19;723(1-2):221-32 [10080649] Br J Pharmacol. 2005 Jan;144(2):231-41 [15665862] Clin Chem. 2005 Oct;51(10):1811-22 [16099938] Ann N Y Acad Sci. 2000 Sep;914:104-11 [11085313] J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 17;832(1):81-9 [16436334] J Psychopharmacol. 2006 May;20(3):456-63 [16574720] Xenobiotica. 2006 Feb-Mar;36(2-3):259-67 [16702115] AAPS J. 2006;8(2):E337-47 [16796384] J Neurochem. 2006 Jul;98(2):495-505 [16749908] Psychopharmacology (Berl). 2007 Jan;189(4):407-24 [16541247] J Anal Toxicol. 2006 Oct;30(8):563-9 [17132253] Annu Rev Pharmacol Toxicol. 2007;47:681-98 [17209801] Neurotox Res. 2007 Apr;11(3-4):183-202 [17449459] J Anal Toxicol. 2007 Apr;31(3):138-43 [17579960] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):262-70 [17646137] Biol Psychiatry. 2007 Sep 15;62(6):669-79 [17306775] Biomed Chromatogr. 2007 Oct;21(10):1016-22 [17474141] Clin Chem. 2008 Feb;54(2):379-87 [18089653] Xenobiotica. 2008 Mar;38(3):314-24 [18274959] J Pharm Sci. 2008 Apr;97(4):1593-605 [17724664] Drug Alcohol Rev. 2008 May;27(3):236-42 [18368604] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):78-83 [18396472] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 15;874(1-2):119-24 [18829400] J Neurosci. 1999 Nov 15;19(22):10107-15 [10559418] J Pharm Biomed Anal. 1999 Dec;21(4):739-47 [10701939] Neurology. 2000 Mar 28;54(6):1344-9 [10746608] Mol Pharmacol. 2000 Dec;58(6):1247-56 [11093760] Neuroscience. 2001;107(2):265-74 [11731100] Drug Alcohol Depend. 2002 Apr 1;66(2):147-59 [11906802] J Anal Toxicol. 2002 Apr;26(3):157-65 [11991532] Neurosci Res. 2002 Jul;43(3):251-7 [12103443] Clin Chem. 2002 Sep;48(9):1472-85 [12194924] Rapid Commun Mass Spectrom. 2003;17(4):330-6 [12569443] J Anal Toxicol. 2003 Mar;27(2):78-87 [12670001] Brain Res Brain Res Rev. 2003 May;42(2):155-68 [12738056] J Mass Spectrom. 2003 Jun;38(6):659-76 [12827635] J Neurochem. 2003 Jul;86(2):413-21 [12871582] Pharmacol Rev. 2003 Sep;55(3):463-508 [12869661] FASEB J. 2003 Oct;17(13):1775-88 [14519657] Biomed Chromatogr. 2003 Oct;17(7):471-6 [14598332] J Anal Toxicol. 2003 Nov-Dec;27(8):552-9 [14670133] J Neurosci. 2004 Mar 3;24(9):2212-25 [14999072] Psychopharmacology (Berl). 2004 May;173(3-4):310-7 [14747902] Psychopharmacology (Berl). 2004 May;173(3-4):249-63 [15083264] Biol Mass Spectrom. 1993 Jul;22(7):403-11 [8102882] J Chromatogr B Biomed Appl. 1995 Feb 17;664(2):449-57 [7780602] J Anal Toxicol. 1996 Oct;20(6):432-40 [8889680] J Neurochem. 1997 Aug;69(2):780-90 [9231739] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jchromb.2008.11.001 ER - TY - JOUR T1 - Age, sex, and race influence single-strand break repair capacity in a human population. AN - 69843217; 18845243 AB - Recently, we developed an improved comet assay protocol for evaluating single-strand break repair capacity (SSB-RC) in unstimulated cryopreserved human peripheral blood mononuclear cells (PBMCs). This methodology facilitates control of interexperimental variability [A.R. Trzeciak, J. Barnes, M.K. Evans, A modified alkaline comet assay for measuring DNA repair capacity in human populations. Radiat. Res. 169 (2008) 110-121]. The fast component of SSB repair (F-SSB-RC) was assessed using a novel parameter, the initial rate of DNA repair, and the widely used half-time of DNA repair. The slow component of SSB repair (S-SSB-RC) was estimated using the residual DNA damage after 60 min. We have examined repair of gamma-radiation-induced DNA damage in PBMCs from four age-matched groups of male and female whites and African-Americans between ages 30 and 64. There is an increase in F-SSB-RC with age in white females (P<0.01) and nonsignificant decrease in F-SSB-RC in African-American females (P=0.061). F-SSB-RC is lower in white females than in white males (P<0.01). There is a decrease in F-SSB-RC with age in African-American females as compared to white females (P<0.002) and African-American males (nonsignificant, P=0.059). Age, sex, and race had a similar effect on intercellular variability of DNA damage in gamma-irradiated and repairing PBMCs. Our findings suggest that age, sex, and race influence SSB-RC as measured by the alkaline comet assay. SSB-RC may be a useful clinical biomarker. JF - Free radical biology & medicine AU - Trzeciak, Andrzej R AU - Barnes, Janice AU - Ejiogu, Ngozi AU - Foster, Kamala AU - Brant, Larry J AU - Zonderman, Alan B AU - Evans, Michele K AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 1631 EP - 1641 VL - 45 IS - 12 SN - 0891-5849, 0891-5849 KW - DNA, Single-Stranded KW - 0 KW - Index Medicus KW - Age Factors KW - Leukocytes, Mononuclear -- radiation effects KW - Sex Factors KW - Gamma Rays KW - Humans KW - African Americans KW - Comet Assay -- methods KW - European Continental Ancestry Group KW - Adult KW - Leukocytes, Mononuclear -- metabolism KW - Middle Aged KW - Female KW - Male KW - Continental Population Groups -- genetics KW - DNA, Single-Stranded -- genetics KW - DNA Repair KW - DNA, Single-Stranded -- analysis KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69843217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Age%2C+sex%2C+and+race+influence+single-strand+break+repair+capacity+in+a+human+population.&rft.au=Trzeciak%2C+Andrzej+R%3BBarnes%2C+Janice%3BEjiogu%2C+Ngozi%3BFoster%2C+Kamala%3BBrant%2C+Larry+J%3BZonderman%2C+Alan+B%3BEvans%2C+Michele+K&rft.aulast=Trzeciak&rft.aufirst=Andrzej&rft.date=2008-12-15&rft.volume=45&rft.issue=12&rft.spage=1631&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2008.08.031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-23 N1 - Date created - 2008-11-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mutagenesis. 2006 May;21(3):173-8 [16613912] Environ Mol Mutagen. 2006 May;47(4):260-70 [16470524] Mutat Res. 2006 Jun 16;605(1-2):7-16 [16621680] Biochem Biophys Res Commun. 2006 Jun 30;345(2):726-33 [16696946] Environ Res. 2006 Oct;102(2):181-96 [16828737] DNA Repair (Amst). 2007 Jan 4;6(1):45-60 [16982217] Nat Protoc. 2007;2(5):1084-104 [17546000] Age Ageing. 2007 Sep;36(5):521-6 [17913757] Radiat Res. 2008 Jan;169(1):110-21 [18159959] Radiat Environ Biophys. 2001 Mar;40(1):83-9 [11357715] Nucleic Acids Res. 2002 Jan 15;30(2):E1 [11788727] Cancer Res. 2002 May 15;62(10):2791-7 [12019155] Br J Radiol. 2002 Jul;75(895):608-14 [12145135] Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(5):1216-25 [12654430] Acta Biochim Pol. 2003;50(1):181-90 [12673358] Carcinogenesis. 2003 May;24(5):883-9 [12771032] Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):689-98 [12917198] Mutat Res. 2003 Nov 10;541(1-2):1-8 [14568289] Cytogenet Genome Res. 2004;104(1-4):14-20 [15162010] Radiat Environ Biophys. 1983;22(1):3-19 [6611843] Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Nov;50(5):893-908 [3490451] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Radiat Res. 1988 Dec;116(3):511-25 [3060896] Radiat Res. 1990 Apr;122(1):86-94 [2320728] Mutat Res. 1990 May-Jul;237(3-4):123-30 [2233818] Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1614-8 [8434025] Mutat Res. 1993 Oct;294(3):275-83 [7692267] J Invest Dermatol. 1997 Feb;108(2):154-9 [9008227] Mutat Res. 1997 Jan 31;383(1):71-80 [9042421] Mutat Res. 1997 Mar 21;374(2):261-8 [9100849] Mutat Res. 1997 Jun;386(3):315-34 [9219569] Mutat Res. 1998 Mar 16;413(2):111-9 [9639687] Int J Radiat Biol. 1998 Jun;73(6):649-60 [9690683] J Biol Chem. 1998 Sep 18;273(38):24822-31 [9733786] Environ Mol Mutagen. 2000;35(3):206-21 [10737956] Mutat Res. 2000 Sep 20;469(2):181-97 [10984679] Eur J Clin Nutr. 2000 Jun;54 Suppl 3:S77-91 [11041079] J Natl Cancer Inst. 2000 Nov 1;92(21):1764-72 [11058619] Int J Cancer. 2001 Mar 20;95(2):86-91 [11241317] FASEB J. 1998 Oct;12(13):1397-400 [9761783] Radiat Res. 1998 Nov;150(5 Suppl):S42-51 [9806608] Mutagenesis. 2006 May;21(3):205-11 [16613913] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2008.08.031 ER - TY - JOUR T1 - Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease. AN - 69839286; 18782848 AB - The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, the genetic deficiency of the glycogen-degrading lysosomal enzyme acid-alpha glucosidase. Accumulation of lysosomal glycogen, presumably transported from the cytoplasm by the autophagic pathway, occurs in multiple tissues, but pathology is most severe in skeletal and cardiac muscle. Skeletal muscle pathology also involves massive autophagic buildup in the core of myofibers. To determine if glycogen reaches the lysosome via autophagy and to ascertain whether autophagic buildup in Pompe disease is a consequence of induction of autophagy and/or reduced turnover due to defective fusion with lysosomes, we generated muscle-specific autophagy-deficient Pompe mice. We have demonstrated that autophagy is not required for glycogen transport to lysosomes in skeletal muscle. We have also found that Pompe disease involves induction of autophagy but manifests as a functional deficiency of autophagy because of impaired autophagosomal-lysosomal fusion. As a result, autophagic substrates, including potentially toxic aggregate-prone ubiquitinated proteins, accumulate in Pompe myofibers and may cause profound muscle damage. JF - Human molecular genetics AU - Raben, Nina AU - Hill, Victoria AU - Shea, Lauren AU - Takikita, Shoichi AU - Baum, Rebecca AU - Mizushima, Noboru AU - Ralston, Evelyn AU - Plotz, Paul AD - Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1820, USA. rabenn@arb.niams.nih.gov Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 3897 EP - 3908 VL - 17 IS - 24 KW - Proteins KW - 0 KW - alpha-Glucosidases KW - EC 3.2.1.20 KW - Index Medicus KW - Animals KW - Mice KW - alpha-Glucosidases -- deficiency KW - Mice, Transgenic KW - alpha-Glucosidases -- genetics KW - Male KW - Female KW - Mice, Knockout KW - Autophagy -- genetics KW - Muscle, Skeletal -- pathology KW - Muscular Diseases -- pathology KW - Ubiquitination -- genetics KW - Glycogen Storage Disease Type II -- genetics KW - Muscle, Skeletal -- enzymology KW - Proteins -- metabolism KW - Proteins -- genetics KW - Muscular Diseases -- metabolism KW - Glycogen Storage Disease Type II -- enzymology KW - Muscular Diseases -- etiology KW - Proteins -- adverse effects KW - Glycogen Storage Disease Type II -- pathology KW - Muscle, Skeletal -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Suppression+of+autophagy+in+skeletal+muscle+uncovers+the+accumulation+of+ubiquitinated+proteins+and+their+potential+role+in+muscle+damage+in+Pompe+disease.&rft.au=Raben%2C+Nina%3BHill%2C+Victoria%3BShea%2C+Lauren%3BTakikita%2C+Shoichi%3BBaum%2C+Rebecca%3BMizushima%2C+Noboru%3BRalston%2C+Evelyn%3BPlotz%2C+Paul&rft.aulast=Raben&rft.aufirst=Nina&rft.date=2008-12-15&rft.volume=17&rft.issue=24&rft.spage=3897&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=1460-2083&rft_id=info:doi/10.1093%2Fhmg%2Fddn292 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-16 N1 - Date created - 2008-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Mol Genet. 2008 Jan 1;17(1):119-29 [17913701] Cell. 2007 Dec 14;131(6):1149-63 [18083104] Nature. 2008 Feb 28;451(7182):1069-75 [18305538] Traffic. 2008 Apr;9(4):574-87 [18182013] Autophagy. 2008 May;4(4):524-6 [18367868] Autophagy. 2008 Jul;4(5):727-30 [18437051] J Biol Chem. 2008 Aug 15;283(33):22847-57 [18524774] J Pathol. 1999 Nov;189(3):416-24 [10547605] EMBO J. 2000 Nov 1;19(21):5720-8 [11060023] J Cell Biol. 2001 Feb 19;152(4):657-68 [11266458] Science. 2001 Nov 23;294(5547):1704-8 [11679633] Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14440-5 [11717410] Curr Opin Neurol. 2002 Oct;15(5):525-31 [12351995] FASEB J. 2002 Nov;16(13):1697-712 [12409312] Curr Neurol Neurosci Rep. 2003 Jan;3(1):64-9 [12507414] Cell Struct Funct. 2002 Dec;27(6):421-9 [12576635] Biochim Biophys Acta. 2003 Mar 20;1637(2):164-70 [12633905] Biochem Biophys Res Commun. 2004 Jan 9;313(2):453-8 [14684184] FASEB J. 2004 Jan;18(1):39-51 [14718385] Microsc Res Tech. 2004 Feb 1;63(2):87-93 [14722905] Oncogene. 2004 Mar 15;23(11):2057-70 [15021893] Dev Cell. 2004 Apr;6(4):463-77 [15068787] Cell. 2004 Apr 30;117(3):399-412 [15109499] Microsc Res Tech. 2004 May 1;64(1):10-20 [15287014] Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18 [15325588] J Cell Biol. 1972 Jan;52(1):41-51 [4331300] Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(1):23-36 [6199885] J Morphol. 1994 Aug;221(2):177-90 [7932768] J Biol Chem. 1998 Jul 24;273(30):19086-92 [9668092] Nucleic Acids Res. 1999 Oct 1;27(19):e27 [10481039] Biochim Biophys Acta. 2004 Nov 29;1695(1-3):89-111 [15571811] Mol Ther. 2005 Jan;11(1):48-56 [15585405] J Cell Sci. 2005 Jan 1;118(Pt 1):7-18 [15615779] Nature. 2004 Dec 23;432(7020):1032-6 [15525940] J Biomech. 2005 May;38(5):1035-43 [15797585] J Cell Biol. 2005 May 9;169(3):425-34 [15866887] Histol Histopathol. 2005 Jul;20(3):689-96 [15944916] J Neuropathol Exp Neurol. 2005 Jun;64(6):513-22 [15977643] J Cell Biol. 2005 Nov 21;171(4):603-14 [16286508] Am J Pathol. 2005 Dec;167(6):1713-28 [16314482] Traffic. 2006 Feb;7(2):129-45 [16420522] Ann Neurol. 2006 Apr;59(4):700-8 [16532490] Nature. 2006 Jun 15;441(7095):885-9 [16625204] Nature. 2006 Jun 15;441(7095):880-4 [16625205] J Pediatr. 2006 Jul;149(1):89-97 [16860134] Pathol Res Pract. 2006;202(9):631-8 [16781826] Autophagy. 2006 Oct-Dec;2(4):318-20 [16874053] J Biol Chem. 2006 Nov 24;281(47):36303-16 [16963441] Lab Invest. 2006 Dec;86(12):1208-20 [17075580] Mol Ther. 2006 Dec;14(6):831-9 [17008131] Curr Neurol Neurosci Rep. 2007 Jan;7(1):71-7 [17217857] Autophagy. 2007 May-Jun;3(3):259-62 [17329960] Hum Mol Genet. 2007 Apr 15;16(8):919-28 [17329348] Mol Genet Metab. 2007 Aug;91(4):343-51 [17572127] J Biol Chem. 2007 Aug 17;282(33):24131-45 [17580304] Mol Biol Cell. 2007 Oct;18(10):3952-65 [17686993] Autophagy. 2007 Nov-Dec;3(6):546-52 [17592248] Nat Rev Mol Cell Biol. 2007 Nov;8(11):931-7 [17712358] Autophagy. 2008 Feb;4(2):151-75 [18188003] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/hmg/ddn292 ER - TY - JOUR T1 - Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir. AN - 69820643; 18991509 AB - We report the first case of a human immunodeficiency virus type 1 (HIV-1)-infected individual receiving combination antiretroviral therapy, which included ritonavir, who developed Cushing syndrome with profound complications after epidural triamcinolone injections. This case highlights the potential of ritonavir interactions even with local injections of a corticosteroid. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Ramanathan, Roshan AU - Pau, Alice K AU - Busse, Kristin H AU - Zemskova, Marina AU - Nieman, Lynnette AU - Kwan, Richard AU - Hammer, Jean H AU - Mican, JoAnn M AU - Maldarelli, Frank AD - Clinical Parasitology Unit and Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. ramanathanr@niaid.nih.gov Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - e97 EP - e99 VL - 47 IS - 12 KW - Pyrimidinones KW - 0 KW - Triamcinolone KW - 1ZK20VI6TY KW - Lopinavir KW - 2494G1JF75 KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - Drug Interactions KW - HIV-1 -- isolation & purification KW - Humans KW - Adult KW - Male KW - Ritonavir -- therapeutic use KW - Triamcinolone -- adverse effects KW - Iatrogenic Disease KW - HIV Infections -- complications KW - Triamcinolone -- administration & dosage KW - HIV Infections -- drug therapy KW - Pyrimidinones -- therapeutic use KW - Cushing Syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69820643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Iatrogenic+Cushing+syndrome+after+epidural+triamcinolone+injections+in+an+HIV+type+1-infected+patient+receiving+therapy+with+ritonavir-lopinavir.&rft.au=Ramanathan%2C+Roshan%3BPau%2C+Alice+K%3BBusse%2C+Kristin+H%3BZemskova%2C+Marina%3BNieman%2C+Lynnette%3BKwan%2C+Richard%3BHammer%2C+Jean+H%3BMican%2C+JoAnn+M%3BMaldarelli%2C+Frank&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-15&rft.volume=47&rft.issue=12&rft.spage=e97&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/10.1086%2F593314 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-24 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharm Pharmacol. 2003 Mar;55(3):381-6 [12724045] Clin Exp Immunol. 1976 Apr;24(1):54-62 [1084818] Clin Pharmacol Ther. 1986 Mar;39(3):313-7 [3948470] J Clin Pharmacol. 1994 Aug;34(8):854-8 [7962675] Clin Biochem. 2005 Jun;38(6):531-4 [15885232] AIDS Read. 2008 Feb;18(2):100-4 [18333287] J Clin Endocrinol Metab. 2005 Jul;90(7):4394-8 [15755851] J Acquir Immune Defic Syndr. 2005 Dec 15;40(5):573-80 [16284534] Endocr Pract. 2005 Nov-Dec;11(6):408-10 [16638729] Ther Drug Monit. 2007 Dec;29(6):687-710 [18043468] Drug Metab Dispos. 2005 Jun;33(6):764-70 [15764714] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1086/593314 ER - TY - JOUR T1 - SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap AN - 20274009; 8920964 AB - Summary: The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies).Availability: SNAP server is available at http://www.broad.mit.edu/mpg/snap/.Contact: debakkerroad.mit.edu JF - Bioinformatics AU - Johnson, Andrew D AU - Handsaker, Robert E AU - Pulit, Sara L AU - Nizzari, Marcia M AU - O'Donnell, Christopher J AU - de Bakker, Paul IW AD - 1 The Framingham Heart Study of the National Heart, Lung, and Blood Institute of the National Institutes of Health and Boston University School of Medicine, Framingham, MA 01702, 2 Broad Institute of MIT and Harvard, Cambridge, MA 02142, 3 Division of Genetics, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School-Partners HealthCare Center for Genetics and Genomics, 77 Avenue Louis Pasteur, Boston, MA 02215 and 4 Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 2938 EP - 2939 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 24 IS - 24 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Linkage disequilibrium KW - Data processing KW - Single-nucleotide polymorphism KW - Computer graphics KW - Bioinformatics KW - genomics KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20274009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SNAP%3A+a+web-based+tool+for+identification+and+annotation+of+proxy+SNPs+using+HapMap&rft.au=Johnson%2C+Andrew+D%3BHandsaker%2C+Robert+E%3BPulit%2C+Sara+L%3BNizzari%2C+Marcia+M%3BO%27Donnell%2C+Christopher+J%3Bde+Bakker%2C+Paul+IW&rft.aulast=Johnson&rft.aufirst=Andrew&rft.date=2008-12-15&rft.volume=24&rft.issue=24&rft.spage=2938&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn564 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Linkage disequilibrium; Data processing; Single-nucleotide polymorphism; Computer graphics; genomics; Bioinformatics DO - http://dx.doi.org/10.1093/bioinformatics/btn564 ER - TY - JOUR T1 - Polychlorinated dibenzo-p-dioxins/dibenzofuran mass distribution in both start-up and normal condition in the whole municipal solid waste incinerator AN - 19682334; 8615697 AB - Although many researches focused on the polychlorinated dibenzo-p-dioxins/dibenzofuran (PCDD/F) emissions from stack, in the bottom ash and in the surrounding environment, researches focused on PCDD/F mass distributions in the whole incineration plant have seldom been addressed. This study determined PCDD/F emissions in the whole plant. A high-resolution gas chromatograph /high-resolution mass spectrometer was utilized for analyzing 17 PCDD/F species. Experimental results displayed that PCDD/Fs were formed during fly ash from super heater (SH), economizer (EC), semi-dryer absorber (SDA) and fabric filter (FF) was transferred to fly ash pit. Mass distribution ratios of PCDD/Fs in g I-TEQ (Toxicity Equivalency Quantity) per week from stack, SH, EC, SDA, FF, generation and bottom residue (BR) in start-up operations were 14.6%, 0.1%, 8.3%, 1.0%, 41.7%, 33.4% and 0.9%, respectively. Above results indicated that main PCDD/F source in the MSWI was from fly ash. However, the fly ash is easily controlled and PCDD/F emitted from stack flue gases will be difficult to be handled. Therefore, we should pay more attention on PCDD/F emission from flue gases especially from start-up procedure. Besides, fly ash should be controlled by sodium hypophosphite before being landfilled. MSWI did require further detoxification treatments for the solid residues and flue gases. JF - Journal of Hazardous Materials AU - Chen, C K AU - Lin, C AU - Lin, Y C AU - Wang, L C AU - Chang-Chien, G P AD - National Pingtung University of Science and Technology, Nei Pu, Ping Tung 91207, Taiwan, linchieh@mail.npust.edu.tw Y1 - 2008/12/15/ PY - 2008 DA - 2008 Dec 15 SP - 37 EP - 44 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 160 IS - 1 SN - 0304-3894, 0304-3894 KW - Pollution Abstracts; Toxicology Abstracts KW - Detoxification KW - Municipal solid wastes KW - Solid wastes KW - Incineration plants KW - Emissions KW - PCDD KW - Residues KW - Flue gas KW - Fly ash KW - Toxicity KW - Sodium KW - Filters KW - Fabrics KW - Gases KW - Dibenzofuran KW - Dibenzo-p-dioxin KW - Incinerators KW - P 0000:AIR POLLUTION KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19682334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Polychlorinated+dibenzo-p-dioxins%2Fdibenzofuran+mass+distribution+in+both+start-up+and+normal+condition+in+the+whole+municipal+solid+waste+incinerator&rft.au=Chen%2C+C+K%3BLin%2C+C%3BLin%2C+Y+C%3BWang%2C+L+C%3BChang-Chien%2C+G+P&rft.aulast=Chen&rft.aufirst=C&rft.date=2008-12-15&rft.volume=160&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2008.02.077 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fabrics; Filters; Detoxification; Sodium; Gases; Dibenzofuran; Dibenzo-p-dioxin; Incinerators; Fly ash; Toxicity; Solid wastes; Residues; Flue gas; Municipal solid wastes; Incineration plants; Emissions; PCDD DO - http://dx.doi.org/10.1016/j.jhazmat.2008.02.077 ER - TY - CPAPER T1 - Carbon Monoxide Blocks Lipopolysaccharide (LPS)-induced Gene Expression by Interfering with Proximal NF-B Signal Transduction in Human Monocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41913030; 5090089 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chhikara, M AU - Wang, S AU - Kern, S AU - Danner, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Carbon monoxide KW - Signal transduction KW - Gene expression KW - NF-B protein KW - Monocytes KW - Lipopolysaccharides KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Carbon+Monoxide+Blocks+Lipopolysaccharide+%28LPS%29-induced+Gene+Expression+by+Interfering+with+Proximal+NF-B+Signal+Transduction+in+Human+Monocytes.&rft.au=Chhikara%2C+M%3BWang%2C+S%3BKern%2C+S%3BDanner%2C+R&rft.aulast=Chhikara&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Receptor Possessing Chaperone Activity: The Sigma-1 Receptor at the Mitochondrion-associated ER Membrane. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41911458; 5090329 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Hayashi, T AU - Su, T. Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membranes KW - Chaperones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41911458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Receptor+Possessing+Chaperone+Activity%3A+The+Sigma-1+Receptor+at+the+Mitochondrion-associated+ER+Membrane.&rft.au=Hayashi%2C+T%3BSu%2C+T.&rft.aulast=Hayashi&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Metabolism and Signaling in Mouse Embryonic Fibroblasts Derived from an O-GlcNAcase (OGA) Knockout. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41910275; 5090590 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Keembiyehetty, C AU - Comly, M AU - Love, D AU - Robinson, G AU - Hennighausen, L AU - Hanover, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Metabolism KW - Signal transduction KW - Embryo fibroblasts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41910275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Altered+Metabolism+and+Signaling+in+Mouse+Embryonic+Fibroblasts+Derived+from+an+O-GlcNAcase+%28OGA%29+Knockout.&rft.au=Keembiyehetty%2C+C%3BComly%2C+M%3BLove%2C+D%3BRobinson%2C+G%3BHennighausen%2C+L%3BHanover%2C+J&rft.aulast=Keembiyehetty&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drosophila Myosin 7a Is Regulated by Intramolecular Folding. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41907049; 5090878 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Yang, Y AU - Baboolal, T AU - Siththanandan, V AU - Knight, P AU - Peckham, M AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41907049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Drosophila+Myosin+7a+Is+Regulated+by+Intramolecular+Folding.&rft.au=Yang%2C+Y%3BBaboolal%2C+T%3BSiththanandan%2C+V%3BKnight%2C+P%3BPeckham%2C+M%3BSellers%2C+J&rft.aulast=Yang&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of Cadherin 23 Alternate Transcripts and Protein Isoforms in the Mouse and Primate Inner Ear and Retina. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41902761; 5088757 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lagziel, A AU - Overlack, N AU - Wolfrum, U AU - Bernstein, S AU - Morell, R AU - Friedman, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Primates KW - Retina KW - Cadherin 23 KW - Inner ear KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Expression+of+Cadherin+23+Alternate+Transcripts+and+Protein+Isoforms+in+the+Mouse+and+Primate+Inner+Ear+and+Retina.&rft.au=Lagziel%2C+A%3BOverlack%2C+N%3BWolfrum%2C+U%3BBernstein%2C+S%3BMorell%2C+R%3BFriedman%2C+T&rft.aulast=Lagziel&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - One-Dimensional Topography Underlies Rapid Three-Dimensional Cell Migration. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41900455; 5090433 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Doyle, A AU - Wang, F AU - Matsumoto, K AU - Yamada, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Topography KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=One-Dimensional+Topography+Underlies+Rapid+Three-Dimensional+Cell+Migration.&rft.au=Doyle%2C+A%3BWang%2C+F%3BMatsumoto%2C+K%3BYamada%2C+K&rft.aulast=Doyle&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Is Tubulin Glutamylation Good For? An Analysis of Glutamylase Function in C. elegans. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41900281; 5090401 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Peel, N AU - O'Connell, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Tubulin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41900281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=What+Is+Tubulin+Glutamylation+Good+For%3F+An+Analysis+of+Glutamylase+Function+in+C.+elegans.&rft.au=Peel%2C+N%3BO%27Connell%2C+K&rft.aulast=Peel&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Hepatocyte Growth Factor Antagonist Engineered by Site-directed Mutagenesis of HGF/NK1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41899411; 5089086 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Cecchi, F AU - Pajalunga, D AU - Fowler, C AU - Peruzzi, B AU - MacDonald, N AU - Grella, D AU - Wingfield, P AU - Stahl, S AU - Kaufman, J AU - Byrd, A AU - Bottaro, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Growth factors KW - Hepatocyte growth factor KW - Site-directed mutagenesis KW - Mutagenesis KW - Hepatocytes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Hepatocyte+Growth+Factor+Antagonist+Engineered+by+Site-directed+Mutagenesis+of+HGF%2FNK1.&rft.au=Cecchi%2C+F%3BPajalunga%2C+D%3BFowler%2C+C%3BPeruzzi%2C+B%3BMacDonald%2C+N%3BGrella%2C+D%3BWingfield%2C+P%3BStahl%2C+S%3BKaufman%2C+J%3BByrd%2C+A%3BBottaro%2C+D&rft.aulast=Cecchi&rft.aufirst=Sreeparna&rft.date=2009-01-01&rft.volume=51&rft.issue=6&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+Health&rft.issn=13419145&rft_id=info:doi/10.1539%2Fjoh.L9070 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule Investigation of the Acto-Myosin-10 Complex Using Optical Tweezers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898945; 5088962 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Takagi, Y AU - Farrow, R AU - Mashanov, G AU - Batters, C AU - Yang, Y AU - Peckham, M AU - Sellers, J AU - Molloy, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Single+Molecule+Investigation+of+the+Acto-Myosin-10+Complex+Using+Optical+Tweezers.&rft.au=Takagi%2C+Y%3BFarrow%2C+R%3BMashanov%2C+G%3BBatters%2C+C%3BYang%2C+Y%3BPeckham%2C+M%3BSellers%2C+J%3BMolloy%2C+J&rft.aulast=Takagi&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin-X Is Required for Proper Behavior of Neural Crest Cells in Xenopus laevis T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898903; 5088961 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Hwang, Y AU - Luo, T AU - Xu, Y. AU - Sargent, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Neural crest KW - Amphibiotic species KW - Xenopus laevis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin-X+Is+Required+for+Proper+Behavior+of+Neural+Crest+Cells+in+Xenopus+laevis&rft.au=Hwang%2C+Y%3BLuo%2C+T%3BXu%2C+Y.%3BSargent%2C+T&rft.aulast=Hwang&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynein Light Chain LC8 Regulates Syntaphilin-mediated Docking of Axonal Mitochondria. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41898063; 5091065 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chen, Y AU - Gerwin, C AU - Kang, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynein KW - Mitochondria KW - Light chains KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41898063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynein+Light+Chain+LC8+Regulates+Syntaphilin-mediated+Docking+of+Axonal+Mitochondria.&rft.au=Chen%2C+Y%3BGerwin%2C+C%3BKang%2C+J%3BSheng%2C+Z&rft.aulast=Chen&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CDC14 Dysfunction Leads to DNA Under-replication That Is Not Detected by Checkpoints. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41897355; 5089821 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Dulev, S AU - de Renty, C. AU - Schwob, E AU - Strunnikov, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - DNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=CDC14+Dysfunction+Leads+to+DNA+Under-replication+That+Is+Not+Detected+by+Checkpoints.&rft.au=Dulev%2C+S%3Bde+Renty%2C+C.%3BSchwob%2C+E%3BStrunnikov%2C+A&rft.aulast=Dulev&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Versatile Roles of a Splicegenerated C-terminal Extension of hCenexin1 in Polo-like Kinase 1 (Plk1)-dependent Mitotic Functions and Plk1-independent Ninein Recruitment and Ciliogenesis T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41890126; 5089033 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Soung, N AU - Yu, L. AU - Park, J AU - Lee, K AU - Lee, J AU - Veenstra, T AU - Rhee, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Recruitment KW - Polo-like kinase 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41890126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Versatile+Roles+of+a+Splicegenerated+C-terminal+Extension+of+hCenexin1+in+Polo-like+Kinase+1+%28Plk1%29-dependent+Mitotic+Functions+and+Plk1-independent+Ninein+Recruitment+and+Ciliogenesis&rft.au=Soung%2C+N%3BYu%2C+L.%3BPark%2C+J%3BLee%2C+K%3BLee%2C+J%3BVeenstra%2C+T%3BRhee%2C+K&rft.aulast=Soung&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane Fission: Lessons from Lipid Nanotubes and Dynamin. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41888706; 5088660 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Bashkirov, P AU - Sergey, A AU - Schmid, S AU - Zimmerberg, J AU - Frolov, V Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lipids KW - Nanotechnology KW - Membranes KW - Dynamin KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Membrane+Fission%3A+Lessons+from+Lipid+Nanotubes+and+Dynamin.&rft.au=Bashkirov%2C+P%3BSergey%2C+A%3BSchmid%2C+S%3BZimmerberg%2C+J%3BFrolov%2C+V&rft.aulast=Bashkirov&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell Biology in the Genomic Era T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41888614; 5088631 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Collins, Francis Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomics KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cell+Biology+in+the+Genomic+Era&rft.au=Collins%2C+Francis&rft.aulast=Collins&rft.aufirst=Francis&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fluorophore-assisted Light Inactivation of Recombinant 5-HT3A Receptors. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41885517; 5089207 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Morton, R AU - Luo, G AU - Davis, M AU - Hales, T AU - Lovinger, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Inactivation KW - Serotonin S3 receptors KW - Light effects KW - Recombinants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41885517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Fluorophore-assisted+Light+Inactivation+of+Recombinant+5-HT3A+Receptors.&rft.au=Morton%2C+R%3BLuo%2C+G%3BDavis%2C+M%3BHales%2C+T%3BLovinger%2C+D&rft.aulast=Morton&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epigenetic Genome Control by RNAi and Transposon-derived Proteins T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41883291; 5089401 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Grewal, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomes KW - RNA-mediated interference KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41883291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Epigenetic+Genome+Control+by+RNAi+and+Transposon-derived+Proteins&rft.au=Grewal%2C+S&rft.aulast=Grewal&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The N-terminal Regions of the HPS1 and HPS4 Proteins Are Required to Form the Biogenesis of Lysosome-related Organelle Complex 3 (BLOC-3). T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41883076; 5089358 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Carmona, C AU - Bonifacino, J AU - Cadilla, C AU - Gahl, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Organelles KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41883076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+N-terminal+Regions+of+the+HPS1+and+HPS4+Proteins+Are+Required+to+Form+the+Biogenesis+of+Lysosome-related+Organelle+Complex+3+%28BLOC-3%29.&rft.au=Carmona%2C+C%3BBonifacino%2C+J%3BCadilla%2C+C%3BGahl%2C+W&rft.aulast=Carmona&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deletion of the G2 Checkpoint Pathway Downstream Mediator of BRCA1, Wee1, in the Mammary Gland Results in Miscoordination of the Cell Cycle and Extensive DNA Damage. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41877729; 5089058 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Vasilopoulos, A AU - Tominaga, Y AU - Wang, R AU - Deng, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Downstream KW - Mammary gland KW - Cell cycle KW - DNA damage KW - BRCA1 protein KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Deletion+of+the+G2+Checkpoint+Pathway+Downstream+Mediator+of+BRCA1%2C+Wee1%2C+in+the+Mammary+Gland+Results+in+Miscoordination+of+the+Cell+Cycle+and+Extensive+DNA+Damage.&rft.au=Vasilopoulos%2C+A%3BTominaga%2C+Y%3BWang%2C+R%3BDeng%2C+C&rft.aulast=Vasilopoulos&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Traction Stress Variation across Single Focal Adhesions T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41877087; 5088792 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Plotnikov, S AU - Sabass, B AU - Schwarz, U AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Stress KW - Adhesion KW - Traction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Analysis+of+Traction+Stress+Variation+across+Single+Focal+Adhesions&rft.au=Plotnikov%2C+S%3BSabass%2C+B%3BSchwarz%2C+U%3BWaterman%2C+C&rft.aulast=Plotnikov&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of the Endocytic Pathway of ITIM-bearing Inhibitory Receptors: CD94/ NKG2A and LAIR-1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41874289; 5089539 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Peruzzi, G AU - Masilamani, M AU - Narayanan, S AU - Borrego, F AU - Coligan, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41874289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Study+of+the+Endocytic+Pathway+of+ITIM-bearing+Inhibitory+Receptors%3A+CD94%2F+NKG2A+and+LAIR-1.&rft.au=Peruzzi%2C+G%3BMasilamani%2C+M%3BNarayanan%2C+S%3BBorrego%2C+F%3BColigan%2C+J&rft.aulast=Peruzzi&rft.aufirst=G&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Condensin Is Essential for Centromeric Chromatin Assembly and Sister Kinetochore Orientation in Anaphase. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41870232; 5091329 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Samoshkin, A AU - Arnaoutov, A AU - Jansen, L AU - Ouispenski, I AU - Dye, L AU - Karpova, T AU - McNally, J AU - Dasso, M AU - Cleveland, D AU - Strunnikov, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetochores KW - Anaphase KW - Condensin KW - Chromatin remodeling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41870232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Condensin+Is+Essential+for+Centromeric+Chromatin+Assembly+and+Sister+Kinetochore+Orientation+in+Anaphase.&rft.au=Samoshkin%2C+A%3BArnaoutov%2C+A%3BJansen%2C+L%3BOuispenski%2C+I%3BDye%2C+L%3BKarpova%2C+T%3BMcNally%2C+J%3BDasso%2C+M%3BCleveland%2C+D%3BStrunnikov%2C+A&rft.aulast=Samoshkin&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - R-Spondin2/Int7 and Wnt-1 Stimulate Invasiveness and Tumorigenicity of Mammary Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41869222; 5090065 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Klauzinska, M AU - Raafat, A AU - Strizzi, L AU - Baljinnyam, B AU - Endo, Y AU - Rubin, J AU - Callahan, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Invasiveness KW - Epithelial cells KW - Mammary gland KW - Tumorigenicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41869222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=R-Spondin2%2FInt7+and+Wnt-1+Stimulate+Invasiveness+and+Tumorigenicity+of+Mammary+Epithelial+Cells.&rft.au=Klauzinska%2C+M%3BRaafat%2C+A%3BStrizzi%2C+L%3BBaljinnyam%2C+B%3BEndo%2C+Y%3BRubin%2C+J%3BCallahan%2C+R&rft.aulast=Klauzinska&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein-free Liposomes Rescue Nuclear Envelope Formation by Fusion with Membrane Vesicles. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41868823; 5090704 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Rafikova, E AU - Melikov, K AU - Ramos, C AU - Dye, L AU - Chernomordik, L Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Nuclear membranes KW - Membrane vesicles KW - Membrane fusion KW - Liposomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Multiecho+dixon+fat+and+water+separation+method+for+detecting+fibrofatty+infiltration+in+the+myocardium&rft.au=Kellman%2C+Peter%3BHernando%2C+Diego%3BShah%2C+Saurabh%3BZuehlsdorff%2C+Sven%3BJerecic%2C+Renate%3BMancini%2C+Christine%3BLiang%2C+Zhi-Pei%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2009-01-01&rft.volume=61&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21657 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Position of Human Chromosomes Is Conserved in Mouse Nuclei Indicating a Species-independent Mechanism for Maintaining Genome Organization. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41867212; 5090152 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Sengupta, K AU - Camps, J AU - Mathews, P AU - Barenboim-Stapleton, L AU - Nguyen, Q AU - Difi lippantonio, M AU - Ried, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Chromosomes KW - Genomes KW - Nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Position+of+Human+Chromosomes+Is+Conserved+in+Mouse+Nuclei+Indicating+a+Species-independent+Mechanism+for+Maintaining+Genome+Organization.&rft.au=Sengupta%2C+K%3BCamps%2C+J%3BMathews%2C+P%3BBarenboim-Stapleton%2C+L%3BNguyen%2C+Q%3BDifi+lippantonio%2C+M%3BRied%2C+T&rft.aulast=Sengupta&rft.aufirst=K&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Th e Structure of Dynamin Family Members. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41866766; 5090129 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Mears, J AU - Fang, S AU - Ray, P AU - Heymann, J AU - Hinshaw, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41866766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Th+e+Structure+of+Dynamin+Family+Members.&rft.au=Mears%2C+J%3BFang%2C+S%3BRay%2C+P%3BHeymann%2C+J%3BHinshaw%2C+J&rft.aulast=Mears&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Varied Functions of Small, Non-coding RNAs in Bacteria. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41865673; 5090868 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Storz, G AU - Durand, S AU - Fontaine, F AU - Fozo, E AU - Opdyke, J AU - Waters, L AU - Zhang, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Non-coding RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41865673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Varied+Functions+of+Small%2C+Non-coding+RNAs+in+Bacteria.&rft.au=Storz%2C+G%3BDurand%2C+S%3BFontaine%2C+F%3BFozo%2C+E%3BOpdyke%2C+J%3BWaters%2C+L%3BZhang%2C+A&rft.aulast=Storz&rft.aufirst=G&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Medical+mycology&rft.issn=1460-2709&rft_id=info:doi/10.1080%2F13693780802056012 L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cleftin: A Novel Fibronectininduced Gene That Promotes Branching Morphogenesis. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864933; 5090239 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Onodera, T AU - Sakai, T AU - Yamada, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Morphogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cleftin%3A+A+Novel+Fibronectininduced+Gene+That+Promotes+Branching+Morphogenesis.&rft.au=Onodera%2C+T%3BSakai%2C+T%3BYamada%2C+K&rft.aulast=Onodera&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss-of-Function Mutations and Two-Furin Domain Derivatives Reveal Insights about R-spondin2 Structure and Activity. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864572; 5090575 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Li, S. AU - Yen, T AU - Endo, Y AU - Klauzinska, M AU - Baljinnyam, B AU - Macher, B AU - Callahan, R AU - Rubin, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mutation KW - Metabolites KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Loss-of-Function+Mutations+and+Two-Furin+Domain+Derivatives+Reveal+Insights+about+R-spondin2+Structure+and+Activity.&rft.au=Li%2C+S.%3BYen%2C+T%3BEndo%2C+Y%3BKlauzinska%2C+M%3BBaljinnyam%2C+B%3BMacher%2C+B%3BCallahan%2C+R%3BRubin%2C+J&rft.aulast=Li&rft.aufirst=S.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxysterol-binding Proteins Transfer Lipids at Organelle Contact Sites. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41864195; 5090910 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Schulz, T AU - Choi, M AU - Mears, J AU - Hinshaw, J AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lipids KW - Organelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41864195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+reference+services+quarterly&rft.atitle=United+States+National+Library+of+Medicine+Drug+Information+Portal.&rft.au=Hochstein%2C+Colette%3BGoshorn%2C+Jeanne%3BChang%2C+Florence&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2009-01-01&rft.volume=28&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Medical+reference+services+quarterly&rft.issn=1540-9597&rft_id=info:doi/10.1080%2F02763860902816784 L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Synaptic Facilitation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41861609; 5090750 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kang, J AU - Pan, P AU - Tian, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mobility KW - Mitochondria KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Docking+of+Axonal+Mitochondria+by+Syntaphilin+Controls+Their+Mobility+and+Affects+Short-Term+Synaptic+Facilitation.&rft.au=Kang%2C+J%3BPan%2C+P%3BTian%2C+J%3BSheng%2C+Z&rft.aulast=Kang&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Throughput Screening, Probe Development, and the NIH Molecular Libraries Program T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41861099; 5088616 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Charya, Ananth AU - Colvis, Christine AU - Yao, Yong Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Probes KW - High-throughput screening KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=High-Throughput+Screening%2C+Probe+Development%2C+and+the+NIH+Molecular+Libraries+Program&rft.au=Charya%2C+Ananth%3BColvis%2C+Christine%3BYao%2C+Yong&rft.aulast=Charya&rft.aufirst=Ananth&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Is Essential for Focal Adhesion Assembly in Spreading Corneal Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860939; 5088783 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Pan, Q AU - Gao, C AU - Zelenka, P Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Epithelial cells KW - Cyclin-dependent kinase 5 KW - Cell migration KW - Cornea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Collection+and+preparation+of+rodent+tissue+samples+for+histopathological+and+molecular+studies+in+carcinogenesis.&rft.au=Golubeva%2C+Yelena%3BRogers%2C+Keith&rft.aulast=Golubeva&rft.aufirst=Yelena&rft.date=2009-01-01&rft.volume=511&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/10.1007%2F978-1-59745-447-6_1 L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin II Activity Is Necessary for Growth Cone Turning at the Chondroitin Sulfate Proteoglycan Boundary. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860264; 5091188 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Santiago, L AU - Katagiri, Y AU - Geller, H Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Sulfate KW - Myosin KW - Growth cones KW - Chondroitin sulfate KW - Proteoglycans KW - Boundaries KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin+II+Activity+Is+Necessary+for+Growth+Cone+Turning+at+the+Chondroitin+Sulfate+Proteoglycan+Boundary.&rft.au=Santiago%2C+L%3BKatagiri%2C+Y%3BGeller%2C+H&rft.aulast=Santiago&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stable and Prolonged Contacts Form between Cilia of Adjacent Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860216; 5091183 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ott, C AU - Sengupta, P AU - Elia, N AU - Case, L AU - Lippincott- Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cilia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Stable+and+Prolonged+Contacts+Form+between+Cilia+of+Adjacent+Cells.&rft.au=Ott%2C+C%3BSengupta%2C+P%3BElia%2C+N%3BCase%2C+L%3BLippincott-+Schwartz%2C+J&rft.aulast=Ott&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modifications of Membrane Protein Diffusion in P. falciparum-infected Erythrocytes Studied by Quantum Dot-based Multi-particle Tracking. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41860135; 5091374 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Tokumasu, F AU - Clarke, M AU - Crivat, G AU - Ostera, G AU - Hwang, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membrane proteins KW - Erythrocytes KW - Diffusion KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Modifications+of+Membrane+Protein+Diffusion+in+P.+falciparum-infected+Erythrocytes+Studied+by+Quantum+Dot-based+Multi-particle+Tracking.&rft.au=Tokumasu%2C+F%3BClarke%2C+M%3BCrivat%2C+G%3BOstera%2C+G%3BHwang%2C+J&rft.aulast=Tokumasu&rft.aufirst=F&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role of Snapin in Coordinating Late Endocytic Trafficking and Autophagy-Lysosomal Function T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859938; 5088715 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Cai, Q AU - Lu, L. AU - Tian, J AU - Sheng, Z Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Essential+Role+of+Snapin+in+Coordinating+Late+Endocytic+Trafficking+and+Autophagy-Lysosomal+Function&rft.au=Cai%2C+Q%3BLu%2C+L.%3BTian%2C+J%3BSheng%2C+Z&rft.aulast=Cai&rft.aufirst=Q&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biased Gliding of Magnetized Actin Cytoskeleton in Applied Magnetic Field. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859586; 5091267 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chen, Y AU - Conroy, R AU - Sumner, J AU - Moreland, J AU - Koretsky, A Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cytoskeleton KW - Actin KW - Magnetic fields KW - Gliding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Biased+Gliding+of+Magnetized+Actin+Cytoskeleton+in+Applied+Magnetic+Field.&rft.au=Chen%2C+Y%3BConroy%2C+R%3BSumner%2C+J%3BMoreland%2C+J%3BKoretsky%2C+A&rft.aulast=Chen&rft.aufirst=Y&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Th e Spatial Organization of Genomes T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859575; 5088640 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Misteli, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Th+e+Spatial+Organization+of+Genomes&rft.au=Misteli%2C+T&rft.aulast=Misteli&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myosin II Mediates Local Cortical Tension to Guide Endothelial Cell Branching Morphogenesis and Migration in 3D. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41859166; 5090424 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Fischer, R AU - Gardel, M AU - Ma, X. AU - Adelstein, R AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Myosin KW - Cell migration KW - Endothelial cells KW - Cortex KW - Morphogenesis KW - Tension KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myosin+II+Mediates+Local+Cortical+Tension+to+Guide+Endothelial+Cell+Branching+Morphogenesis+and+Migration+in+3D.&rft.au=Fischer%2C+R%3BGardel%2C+M%3BMa%2C+X.%3BAdelstein%2C+R%3BWaterman%2C+C&rft.aulast=Fischer&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bridging Engineering and Life Sciences: Next Generation Tools for Cell Biology T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858941; 5088612 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lee, Jerry Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Bridging+Engineering+and+Life+Sciences%3A+Next+Generation+Tools+for+Cell+Biology&rft.au=Lee%2C+Jerry&rft.aulast=Lee&rft.aufirst=Jerry&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of PolD3 Accessory Subunit in AID-mediated Mutagenesis and Recombination. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858873; 5091548 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Poltoratsky, V AU - Horton, J AU - Wilson, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mutagenesis KW - Recombination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+PolD3+Accessory+Subunit+in+AID-mediated+Mutagenesis+and+Recombination.&rft.au=Poltoratsky%2C+V%3BHorton%2C+J%3BWilson%2C+S&rft.aulast=Poltoratsky&rft.aufirst=V&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - KSR2 Is a Calcineurin Substrate Th at Promotes ERK Cascade Activation in Response to Calcium Signals. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858440; 5088664 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Dougherty, M AU - Specht, S AU - Zhou, M AU - Veenstra, T AU - Morrison, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Calcium signalling KW - Calcineurin KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=KSR2+Is+a+Calcineurin+Substrate+Th+at+Promotes+ERK+Cascade+Activation+in+Response+to+Calcium+Signals.&rft.au=Dougherty%2C+M%3BSpecht%2C+S%3BZhou%2C+M%3BVeenstra%2C+T%3BMorrison%2C+D&rft.aulast=Dougherty&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Localized Production of RanGTP at the Chromatin-Cytoplasm Interface Is Sufficient and Required for Bipolar Mitotic Spindle Assembly in Xenopus laevis Egg Extracts. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41858092; 5090519 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kalab, P AU - Halpin, D AU - Heald, R AU - Weis, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Spindles KW - Amphibiotic species KW - Xenopus laevis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41858092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Localized+Production+of+RanGTP+at+the+Chromatin-Cytoplasm+Interface+Is+Sufficient+and+Required+for+Bipolar+Mitotic+Spindle+Assembly+in+Xenopus+laevis+Egg+Extracts.&rft.au=Kalab%2C+P%3BHalpin%2C+D%3BHeald%2C+R%3BWeis%2C+K&rft.aulast=Kalab&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myofibril Assembly Visualized by Imaging N-RAP, Alpha-Actinin, and Actin in Living Cardiomyocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857816; 5089671 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Manisastry, S AU - Zaal, K AU - Horowits, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cardiomyocytes KW - Actin KW - Imaging techniques KW - Myofibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Myofibril+Assembly+Visualized+by+Imaging+N-RAP%2C+Alpha-Actinin%2C+and+Actin+in+Living+Cardiomyocytes.&rft.au=Manisastry%2C+S%3BZaal%2C+K%3BHorowits%2C+R&rft.aulast=Manisastry&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetic Characterization of the Myosin IIA with an N-terminal GFP Fused Regulatory Light Chain. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857786; 5090427 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kengyel, A AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetics KW - Myosin KW - Light chains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Kinetic+Characterization+of+the+Myosin+IIA+with+an+N-terminal+GFP+Fused+Regulatory+Light+Chain.&rft.au=Kengyel%2C+A%3BSellers%2C+J&rft.aulast=Kengyel&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PIPs Modulate the Sterol Affinity of Oxysterol Binding Proteins at Membrane Contact Sites. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857724; 5088858 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Schulz, T AU - Chung, R AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Membranes KW - Sterols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=PIPs+Modulate+the+Sterol+Affinity+of+Oxysterol+Binding+Proteins+at+Membrane+Contact+Sites.&rft.au=Schulz%2C+T%3BChung%2C+R%3BPrinz%2C+W&rft.aulast=Schulz&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomics Analysis of Focal Adhesion Maturation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857468; 5088794 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kuo, J AU - Han, X AU - Yates, J AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Proteomics KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Proteomics+Analysis+of+Focal+Adhesion+Maturation.&rft.au=Kuo%2C+J%3BHan%2C+X%3BYates%2C+J%3BWaterman%2C+C&rft.aulast=Kuo&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Del-1 (Developmental Endothelial Locus-1) Is an Endogenous Inhibitor of Leukocyte-Endothelial Adhesion Limiting Inflammatory Cell Recruitment. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857383; 5090979 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Choi, E AU - Chavakis, E AU - Czabanka, M AU - Langer, H AU - Fraemohs, L AU - Economopoulou, M AU - Kundu, R AU - Gahmberg, C AU - Udey, M AU - Vajkoczy, P AU - Quertermous, T AU - Dimmeler, S AU - Weber, C AU - Chavakis, T Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Adhesion KW - Recruitment KW - Inflammation KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Del-1+%28Developmental+Endothelial+Locus-1%29+Is+an+Endogenous+Inhibitor+of+Leukocyte-Endothelial+Adhesion+Limiting+Inflammatory+Cell+Recruitment.&rft.au=Choi%2C+E%3BChavakis%2C+E%3BCzabanka%2C+M%3BLanger%2C+H%3BFraemohs%2C+L%3BEconomopoulou%2C+M%3BKundu%2C+R%3BGahmberg%2C+C%3BUdey%2C+M%3BVajkoczy%2C+P%3BQuertermous%2C+T%3BDimmeler%2C+S%3BWeber%2C+C%3BChavakis%2C+T&rft.aulast=Choi&rft.aufirst=E&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Microtubule Plus End- Binding Protein EB1 Is Necessary for Muscle Cell Differentiation, Elongation, and Fusion. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41857070; 5088910 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Zhang, T AU - Zaal, K AU - Reid, E AU - Sheridan, J AU - Mehta, A AU - Gundersen, G AU - Ralston, E Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Muscles KW - Cell differentiation KW - Differentiation KW - Microtubules KW - Elongation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Microtubule+Plus+End-+Binding+Protein+EB1+Is+Necessary+for+Muscle+Cell+Differentiation%2C+Elongation%2C+and+Fusion.&rft.au=Zhang%2C+T%3BZaal%2C+K%3BReid%2C+E%3BSheridan%2C+J%3BMehta%2C+A%3BGundersen%2C+G%3BRalston%2C+E&rft.aulast=Zhang&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nup107-160 Complex and - TuRC Regulate Microtubule Polymerization at Kinetochores. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41855275; 5089796 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Mishra, R AU - Chakraborty, P AU - Arnaoutov, A AU - Fontoura, B AU - Dasso, M Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetochores KW - Microtubules KW - Polymerization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Nup107-160+Complex+and+-+TuRC+Regulate+Microtubule+Polymerization+at+Kinetochores.&rft.au=Mishra%2C+R%3BChakraborty%2C+P%3BArnaoutov%2C+A%3BFontoura%2C+B%3BDasso%2C+M&rft.aulast=Mishra&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of TRPC1-Interacting Proteins by Tandem Mass Spectroscopy. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854988; 5090308 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lockwich, T AU - Makusky, A AU - Kowalak, J AU - Markey, S AU - Ambudkar, I Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Mass spectroscopy KW - Trp protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Analysis+of+TRPC1-Interacting+Proteins+by+Tandem+Mass+Spectroscopy.&rft.au=Lockwich%2C+T%3BMakusky%2C+A%3BKowalak%2C+J%3BMarkey%2C+S%3BAmbudkar%2C+I&rft.aulast=Lockwich&rft.aufirst=T&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LRRK2 Regulates Neurite Outgrowth via Modulation of ERM Phosphorylation and Actin Remodeling. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854950; 5091589 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Parisiadou, L AU - Xie, C AU - Wang, L AU - Gu, X. AU - Lin, X AU - Shim, H AU - Li, Z. AU - Cai, H Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - LRRK2 protein KW - Actin KW - Phosphorylation KW - Axonogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=LRRK2+Regulates+Neurite+Outgrowth+via+Modulation+of+ERM+Phosphorylation+and+Actin+Remodeling.&rft.au=Parisiadou%2C+L%3BXie%2C+C%3BWang%2C+L%3BGu%2C+X.%3BLin%2C+X%3BShim%2C+H%3BLi%2C+Z.%3BCai%2C+H&rft.aulast=Parisiadou&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the Penta-EF-Hand Protein ALG-2 as a Ca2+-dependent Interactor of Mucolipin-1. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854888; 5089447 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Vergarajauregui, S AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Calcium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Identification+of+the+Penta-EF-Hand+Protein+ALG-2+as+a+Ca2%2B-dependent+Interactor+of+Mucolipin-1.&rft.au=Vergarajauregui%2C+S%3BPuertollano%2C+R&rft.aulast=Vergarajauregui&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Reticulons and DP1/ Yop1p in Maintaining ER Tubules. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854681; 5090207 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Voss, C AU - Shibata, Y AU - Rapoport, T AU - Voeltz, G AU - Prinz, W Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Tubules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+Reticulons+and+DP1%2F+Yop1p+in+Maintaining+ER+Tubules.&rft.au=Voss%2C+C%3BShibata%2C+Y%3BRapoport%2C+T%3BVoeltz%2C+G%3BPrinz%2C+W&rft.aulast=Voss&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule Kinetic Measurements of Non-Muscle Myosin IIB Using Optical Tweezers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854641; 5090428 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Nagy, A AU - Takagi, Y AU - Kovacs, M AU - Homsher, E AU - Sellers, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Kinetics KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Single+Molecule+Kinetic+Measurements+of+Non-Muscle+Myosin+IIB+Using+Optical+Tweezers.&rft.au=Nagy%2C+A%3BTakagi%2C+Y%3BKovacs%2C+M%3BHomsher%2C+E%3BSellers%2C+J&rft.aulast=Nagy&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Uptake and Trafficking of Fluorescently Conjugated Dextran and Transferrin: A Comparison of Salivary Gland Fibroblasts in Live Rodents and Isolated Fibroblasts in Culture. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41854206; 5090353 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Masedunskas, A AU - Weigert, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Rodents KW - Fibroblasts KW - Transferrin KW - Salivary gland KW - Dextran KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Uptake+and+Trafficking+of+Fluorescently+Conjugated+Dextran+and+Transferrin%3A+A+Comparison+of+Salivary+Gland+Fibroblasts+in+Live+Rodents+and+Isolated+Fibroblasts+in+Culture.&rft.au=Masedunskas%2C+A%3BWeigert%2C+R&rft.aulast=Masedunskas&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Snapin Plays a Key Role as an Adaptor for CPE Cytoplasmic Tail to Connect Hormone Vesicles to Microtubule Motor Complex. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853678; 5089584 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Park, J AU - Loh, Y Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Hormones KW - Microtubules KW - Vesicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Snapin+Plays+a+Key+Role+as+an+Adaptor+for+CPE+Cytoplasmic+Tail+to+Connect+Hormone+Vesicles+to+Microtubule+Motor+Complex.&rft.au=Park%2C+J%3BLoh%2C+Y&rft.aulast=Park&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MCOLN3 Is Involved in the Trafficking of Cargo Proteins along the Endo/ lysosomal Compartment in the Retinal Pigment Epithelial Cell Line ARPE-19. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853647; 5089446 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Martina, J AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Pigments KW - Retinal pigment epithelium KW - Retina KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=MCOLN3+Is+Involved+in+the+Trafficking+of+Cargo+Proteins+along+the+Endo%2F+lysosomal+Compartment+in+the+Retinal+Pigment+Epithelial+Cell+Line+ARPE-19.&rft.au=Martina%2C+J%3BPuertollano%2C+R&rft.aulast=Martina&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sorting Nexin 27: A Novel Regulator of CFTR Trafficking. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853598; 5089443 JF - 48th Annual Meeting of the American Society for Cell Biology AU - McDermott, M AU - Thelin, W AU - Lyons, P AU - Gentzsch, M AU - Hong, W AU - Stutts, M AU - Milgram, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Nexin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Sorting+Nexin+27%3A+A+Novel+Regulator+of+CFTR+Trafficking.&rft.au=McDermott%2C+M%3BThelin%2C+W%3BLyons%2C+P%3BGentzsch%2C+M%3BHong%2C+W%3BStutts%2C+M%3BMilgram%2C+S&rft.aulast=McDermott&rft.aufirst=M&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Angiotensin IIInduced ERK1/2 Activation in Primary Fetal Cardiomyocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853355; 5089877 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Yin, X AU - Zhang, M AU - Hu, L. AU - Catt, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cardiomyocytes KW - Angiotensin KW - Fetuses KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Mechanism+of+Angiotensin+IIInduced+ERK1%2F2+Activation+in+Primary+Fetal+Cardiomyocytes.&rft.au=Yin%2C+X%3BZhang%2C+M%3BHu%2C+L.%3BCatt%2C+K&rft.aulast=Yin&rft.aufirst=X&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin Regulates Apical Constriction in Epithelial Monolayers. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41853253; 5089599 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Chua, J AU - Rikhy, R AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Dynamin KW - Monomolecular films KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynamin+Regulates+Apical+Constriction+in+Epithelial+Monolayers.&rft.au=Chua%2C+J%3BRikhy%2C+R%3BLippincott-Schwartz%2C+J&rft.aulast=Chua&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Targeting of Misfolded Proteins in the Endoplasmic Reticulum for Degradation by Autophagy. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851398; 5090942 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Satpute- Krishnan, P AU - Hegde, R AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Degradation KW - Protein folding KW - Endoplasmic reticulum KW - Phagocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Selective+Targeting+of+Misfolded+Proteins+in+the+Endoplasmic+Reticulum+for+Degradation+by+Autophagy.&rft.au=Satpute-+Krishnan%2C+P%3BHegde%2C+R%3BLippincott-Schwartz%2C+J&rft.aulast=Satpute-+Krishnan&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SIRT1 Inhibitor Alleviates FMR1 Gene Silencing in Fragile X Cell Lines T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851248; 5091415 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Biacsi, R AU - Kumari, D AU - Usdin, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Gene silencing KW - SIRT1 protein KW - Fragile X mental retardation protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=SIRT1+Inhibitor+Alleviates+FMR1+Gene+Silencing+in+Fragile+X+Cell+Lines&rft.au=Biacsi%2C+R%3BKumari%2C+D%3BUsdin%2C+K&rft.aulast=Biacsi&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Nef Mediates Ubiquitination-independent Targeting of CD4 to the MVB Pathway. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41851107; 5090853 JF - 48th Annual Meeting of the American Society for Cell Biology AU - daSilva, L AU - Sougrat, R AU - Burgos, P AU - Janvier, K AU - Bonifacino, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Nef protein KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=HIV-1+Nef+Mediates+Ubiquitination-independent+Targeting+of+CD4+to+the+MVB+Pathway.&rft.au=daSilva%2C+L%3BSougrat%2C+R%3BBurgos%2C+P%3BJanvier%2C+K%3BBonifacino%2C+J&rft.aulast=daSilva&rft.aufirst=L&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Activity Regulates Cytoskeletal Organization by Controlling Rhodependent Myosin Phosphorylation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849910; 5091137 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Tripathi, B AU - Gao, C AU - Zelenka, P Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Cytoskeleton KW - Cyclin-dependent kinase 5 KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cdk5+Activity+Regulates+Cytoskeletal+Organization+by+Controlling+Rhodependent+Myosin+Phosphorylation.&rft.au=Tripathi%2C+B%3BGao%2C+C%3BZelenka%2C+P&rft.aulast=Tripathi&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topology Rather than Cell Lineage Determines the Presence of the Subcortical Maternal Complex in Preimplantation Mouse Development. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849882; 5090763 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Baibakov, B AU - Li, L. AU - Dean, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cell lineage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Topology+Rather+than+Cell+Lineage+Determines+the+Presence+of+the+Subcortical+Maternal+Complex+in+Preimplantation+Mouse+Development.&rft.au=Baibakov%2C+B%3BLi%2C+L.%3BDean%2C+J&rft.aulast=Baibakov&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Distribution of the Feminization Factor Homolog Fem1b in Human Epithelial Cells. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41849564; 5090925 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lelouvier, B AU - Martina, J AU - Puertollano, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Epithelial cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Intracellular+Distribution+of+the+Feminization+Factor+Homolog+Fem1b+in+Human+Epithelial+Cells.&rft.au=Lelouvier%2C+B%3BMartina%2C+J%3BPuertollano%2C+R&rft.aulast=Lelouvier&rft.aufirst=B&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin Regulates Actin Cytoskeleton Remodeling for Metaphase Furrow Formation through Diaphanous in the Syncytial Drosophila Blastoderm. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41848536; 5091451 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Rikhy, R AU - Mavrakis, M AU - Lippincott-Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Metaphase KW - Cytoskeleton KW - Blastoderm KW - Actin KW - Dynamin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dynamin+Regulates+Actin+Cytoskeleton+Remodeling+for+Metaphase+Furrow+Formation+through+Diaphanous+in+the+Syncytial+Drosophila+Blastoderm.&rft.au=Rikhy%2C+R%3BMavrakis%2C+M%3BLippincott-Schwartz%2C+J&rft.aulast=Rikhy&rft.aufirst=R&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/Wednesday_08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intercellular Transfer to Signaling Endosomes for Targeted Regulation within a Bone Marrow Niche. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41847913; 5090267 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Gillette, J AU - Lippincott- Schwartz, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Bone marrow KW - Niches KW - Signal transduction KW - Endosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Intercellular+Transfer+to+Signaling+Endosomes+for+Targeted+Regulation+within+a+Bone+Marrow+Niche.&rft.au=Gillette%2C+J%3BLippincott-+Schwartz%2C+J&rft.aulast=Gillette&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Sel1-domain Protein EnhC in Host Cell Entry by the Obligate Intracellular Bacterium Coxiella burnetii. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844921; 5089308 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Gilk, S AU - Cirillo, S AU - Cirillo, J AU - Heinzen, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Proteins KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+the+Sel1-domain+Protein+EnhC+in+Host+Cell+Entry+by+the+Obligate+Intracellular+Bacterium+Coxiella+burnetii.&rft.au=Gilk%2C+S%3BCirillo%2C+S%3BCirillo%2C+J%3BHeinzen%2C+R&rft.aulast=Gilk&rft.aufirst=S&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel E3 Ubiquitin Ligase LNXL Determines Dorso-Ventral Body Patterning by Negatively Regulating Bozozok Stability T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844900; 5089225 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ro, H. AU - Dawid, I Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Ubiquitin-protein ligase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Novel+E3+Ubiquitin+Ligase+LNXL+Determines+Dorso-Ventral+Body+Patterning+by+Negatively+Regulating+Bozozok+Stability&rft.au=Ro%2C+H.%3BDawid%2C+I&rft.aulast=Ro&rft.aufirst=H.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tubulin Binding to Mitochondrial Outer Membrane through Interaction of the C-terminal "Tails" with VDAC Regulates Respiration - Biophysics, Physiology, and Evolution. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844790; 5090398 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Sherm, J AU - Rostovtseva, T AU - Monge, C AU - Sheldon, K AU - Wolff, J AU - Saks, V AU - Bezrukov, S AU - Sackett, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Respiration KW - Outer membranes KW - Physiology KW - Biophysics KW - Mitochondria KW - Tubulin KW - Electron transport KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Tubulin+Binding+to+Mitochondrial+Outer+Membrane+through+Interaction+of+the+C-terminal+%22Tails%22+with+VDAC+Regulates+Respiration+-+Biophysics%2C+Physiology%2C+and+Evolution.&rft.au=Sherm%2C+J%3BRostovtseva%2C+T%3BMonge%2C+C%3BSheldon%2C+K%3BWolff%2C+J%3BSaks%2C+V%3BBezrukov%2C+S%3BSackett%2C+D&rft.aulast=Sherm&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Trafficking Routes for Cargo Proteins Entering Cells via Clathrinindependent Endocytosis. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844544; 5090354 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Eyster, C AU - Huebner, R AU - Higginson, J AU - Porat-Shliom, N AU - Weigert, R AU - Donaldson, J Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Trafficking KW - Endocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=New+Trafficking+Routes+for+Cargo+Proteins+Entering+Cells+via+Clathrinindependent+Endocytosis.&rft.au=Eyster%2C+C%3BHuebner%2C+R%3BHigginson%2C+J%3BPorat-Shliom%2C+N%3BWeigert%2C+R%3BDonaldson%2C+J&rft.aulast=Eyster&rft.aufirst=C&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SirT1 Represses MMP13 Expression in Human Articular Chondrocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844195; 5089455 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Lee, E AU - Gagarina, V AU - Dvir-Ginzburg, M AU - Hall, D Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Collagenase 3 KW - Chondrocytes KW - SIRT1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=SirT1+Represses+MMP13+Expression+in+Human+Articular+Chondrocytes.&rft.au=Lee%2C+E%3BGagarina%2C+V%3BDvir-Ginzburg%2C+M%3BHall%2C+D&rft.aulast=Lee&rft.aufirst=E&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nonmuscle Myosin II-A Motor Domain Is Important for Early Mouse Embryonic Development. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844122; 5090426 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Wang, A AU - Ma, X. AU - Adelstein, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Myosin KW - Embryogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Nonmuscle+Myosin+II-A+Motor+Domain+Is+Important+for+Early+Mouse+Embryonic+Development.&rft.au=Wang%2C+A%3BMa%2C+X.%3BAdelstein%2C+R&rft.aulast=Wang&rft.aufirst=A&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Effect of Ablation of Nonmuscle Myosin II-B and II-C on Karyokinesis in Mouse Cardiac Myocytes. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41844078; 5090425 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ma, X. AU - Kawamoto, S AU - Conti, M AU - Jana, S AU - Adelstein, R Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Synergistic effects KW - Cardiomyocytes KW - Myosin KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Synergistic+Effect+of+Ablation+of+Nonmuscle+Myosin+II-B+and+II-C+on+Karyokinesis+in+Mouse+Cardiac+Myocytes.&rft.au=Ma%2C+X.%3BKawamoto%2C+S%3BConti%2C+M%3BJana%2C+S%3BAdelstein%2C+R&rft.aulast=Ma&rft.aufirst=X.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of Anthrax Lethal Toxin: Impact of the N-Terminal Amino Acid. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41843124; 5089356 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Gupta, P AU - Moayeri, M AU - Leppla, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Anthrax lethal toxin KW - Amino acids KW - Toxins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Activity+of+Anthrax+Lethal+Toxin%3A+Impact+of+the+N-Terminal+Amino+Acid.&rft.au=Gupta%2C+P%3BMoayeri%2C+M%3BLeppla%2C+S&rft.aulast=Gupta&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of NHERF-1 in the Regulation of T Lymphocyte Adhesion and Migration. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41843022; 5089731 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Ben Aissa, K AU - Liu, Y AU - Shomer, I AU - Hao, J AU - Steplock, D AU - Weinman, E AU - Shaw, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Migration KW - Adhesion KW - Lymphocytes KW - Leukocyte migration KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41843022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+NHERF-1+in+the+Regulation+of+T+Lymphocyte+Adhesion+and+Migration.&rft.au=Ben+Aissa%2C+K%3BLiu%2C+Y%3BShomer%2C+I%3BHao%2C+J%3BSteplock%2C+D%3BWeinman%2C+E%3BShaw%2C+S&rft.aulast=Ben+Aissa&rft.aufirst=K&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Queen's University T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41842923; 5089351 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Li, H. AU - Lee, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Cancer KW - Genetics KW - Pathology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Pathology+and+Molecular+Medicine%2C+Division+of+Cancer+Biology+and+Genetics%2C+Queen%27s+University&rft.au=Li%2C+H.%3BLee%2C+S&rft.aulast=Li&rft.aufirst=H.&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three Dimensional Superresolution Fluorescence Microscopy Reveals Protein Stratification in Focal Adhesions. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41842158; 5088793 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Kanchanawong, P AU - Shtengel, G AU - Davidson, M AU - Hess, H AU - Waterman, C Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Stratification KW - Fluorescence microscopy KW - Adhesion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41842158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Three+Dimensional+Superresolution+Fluorescence+Microscopy+Reveals+Protein+Stratification+in+Focal+Adhesions.&rft.au=Kanchanawong%2C+P%3BShtengel%2C+G%3BDavidson%2C+M%3BHess%2C+H%3BWaterman%2C+C&rft.aulast=Kanchanawong&rft.aufirst=P&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LOK is the Dominant ERM Kinase in Resting Lymphocytes and Regulates Cytoskeletal Rearrangement through ERM Phosphorylation. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41838732; 5089616 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Belkina, N AU - Liu, Y AU - Hao, J AU - Shaw, S Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Lymphocytes KW - Cytoskeleton KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=LOK+is+the+Dominant+ERM+Kinase+in+Resting+Lymphocytes+and+Regulates+Cytoskeletal+Rearrangement+through+ERM+Phosphorylation.&rft.au=Belkina%2C+N%3BLiu%2C+Y%3BHao%2C+J%3BShaw%2C+S&rft.aulast=Belkina&rft.aufirst=N&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determinants of the Specificity of Plk1 PBD Binding and Development of a Highly Sensitive Plk1 ELISA Assay. T2 - 48th Annual Meeting of the American Society for Cell Biology AN - 41838133; 5089806 JF - 48th Annual Meeting of the American Society for Cell Biology AU - Park, J AU - Moulaei, T AU - Lim, D AU - Kang, Y AU - Strebhardt, K AU - Yaffe, M AU - Wlodawer, A AU - Lee, K Y1 - 2008/12/13/ PY - 2008 DA - 2008 Dec 13 KW - Polo-like kinase 1 KW - ELISA KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Determinants+of+the+Specificity+of+Plk1+PBD+Binding+and+Development+of+a+Highly+Sensitive+Plk1+ELISA+Assay.&rft.au=Park%2C+J%3BMoulaei%2C+T%3BLim%2C+D%3BKang%2C+Y%3BStrebhardt%2C+K%3BYaffe%2C+M%3BWlodawer%2C+A%3BLee%2C+K&rft.aulast=Park&rft.aufirst=J&rft.date=2008-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/files/am08/program08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - UV radiation regulates Mi-2 through protein translation and stability. AN - 69866902; 18922793 AB - Dermatomyositis (DM) is an autoimmune disease, which is often accompanied by the development of disease-specific autoantibodies directed against the SNF2-superfamily helicase, Mi-2. Recent evidence suggests that ultraviolet radiation exposure may be an important risk factor for the development of not only the disease but also specific autoimmunity against Mi-2. Consequently, we investigated the effects of ultraviolet radiation on Mi-2 protein expression. We observed an increase in protein levels upon ultraviolet radiation exposure in cell culture systems. These changes in expression occur quite rapidly, are maximized just 1 h following exposure, and are unique to Mi-2 when compared with other members of the NuRD complex. Changes in protein levels are not mediated through transcriptional mechanisms. Treatment results in a more efficiently translated message through regulatory elements in the 5'-UTR region of the transcript. Investigation into protein half-life further demonstrated increased stability of Mi-2 following UV exposure. Taken together, we describe a system by which Mi-2 protein expression can be quickly increased following UV exposure and then maintained up to 16 h later. These data provide a novel regulation of an important transcriptional regulator and provide insight into the possible mechanisms of the development of DM and associated autoantibodies. JF - The Journal of biological chemistry AU - Burd, Craig J AU - Kinyamu, H Karimi AU - Miller, Frederick W AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Intitutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 34976 EP - 34982 VL - 283 IS - 50 SN - 0021-9258, 0021-9258 KW - 5' Untranslated Regions KW - 0 KW - Autoantibodies KW - Autoantigens KW - CHD4 protein, human KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - EC 3.5.1.98 KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Plasmids -- metabolism KW - Humans KW - Autoantibodies -- chemistry KW - Transcription, Genetic KW - Cell Line, Tumor KW - Cell Separation KW - Models, Biological KW - Risk Factors KW - Flow Cytometry KW - Keratinocytes -- metabolism KW - Time Factors KW - Ultraviolet Rays KW - DNA Helicases -- metabolism KW - Protein Biosynthesis -- radiation effects KW - Autoantigens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69866902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=UV+radiation+regulates+Mi-2+through+protein+translation+and+stability.&rft.au=Burd%2C+Craig+J%3BKinyamu%2C+H+Karimi%3BMiller%2C+Frederick+W%3BArcher%2C+Trevor+K&rft.aulast=Burd&rft.aufirst=Craig&rft.date=2008-12-12&rft.volume=283&rft.issue=50&rft.spage=34976&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M805383200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Dec 15;59(24):6087-90 [10626795] Nature. 1998 Oct 29;395(6705):917-21 [9804427] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9209-14 [10922072] Nature. 2002 Aug 29;418(6901):994-8 [12198550] Mol Cell. 2002 Dec;10(6):1441-52 [12504018] Rheumatology (Oxford). 2003 Jan;42(1):34-9 [12509610] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8354-9 [12821781] Arthritis Rheum. 2003 Aug;48(8):2285-93 [12905483] Semin Oncol. 2003 Oct;30(5 Suppl 16):30-7 [14613024] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):3-11 [15020040] Immunity. 2004 Jun;20(6):719-33 [15189737] Arthritis Rheum. 1985 Jul;28(7):796-803 [2409985] Am J Med. 1994 May;96(5):457-62 [8192178] J Rheumatol. 1998 Feb;25(2):395-6 [9489847] Mol Cell. 1998 Dec;2(6):851-61 [9885572] Immunity. 1999 Mar;10(3):345-55 [10204490] Mol Endocrinol. 2004 Dec;18(12):2937-49 [15358836] J Exp Med. 2005 Feb 21;201(4):591-601 [15728237] Curr Rheumatol Rep. 2005 Apr;7(2):99-105 [15760588] Autoimmunity. 2005 Feb;38(1):79-83 [15966133] Cell. 2005 Oct 7;123(1):49-63 [16213212] EMBO J. 2006 Sep 6;25(17):3986-97 [16932743] Clin Dermatol. 2006 Sep-Oct;24(5):363-73 [16966018] Curr Opin Rheumatol. 2006 Nov;18(6):620-4 [17053509] Joint Bone Spine. 2006 Dec;73(6):646-54 [17110150] J Biol Chem. 2007 May 11;282(19):13994-4005 [17344210] Oncogene. 2007 Aug 13;26(37):5433-8 [17694084] Mol Biol Cell. 2007 Sep;18(9):3667-80 [17626165] Mol Endocrinol. 2007 Dec;21(12):2907-18 [17761946] Nat Clin Pract Rheumatol. 2008 Apr;4(4):201-9 [18319710] Curr Biol. 1998 Jul 2;8(14):843-6 [9663395] Cell. 1998 Oct 16;95(2):279-89 [9790534] J Biol Chem. 2000 Jun 9;275(23):17771-7 [10748103] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M805383200 ER - TY - JOUR T1 - Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study AN - 20734936; 8934121 AB - Background Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric add concentration and gout. Methods Genome-wide association studies were done for serum uric add in 7699 participants in the Framingham cohort and in 4148 participants in the Rotterdam cohort. Genome-wide significant single nudeotide polymorphisms (SNPs) were replicated in white (n=11 024) and black (n=3843) individuals who took part in the study of Atherosderosis Risk in Communities (ARIC). The SNPs that readied genome-wide significant association with uric add in either the Framingham cohort (p<5 times 0x10 super(-8)) or the Rotterdam cohort (p<1 times 0x10 super(-7)) were evaluated with gout The results obtained in white participants were combined using meta-analysis. Findings Three loci in the Framingham cohort and two in the Rotterdam cohort showed genome-wide association with uric add. Top SNPs in each locus were: missense rs16890979 in SLC2A9 (p=7 times 0x10 super(-168) and 2 times 9x10 super(-18) for white and black participants, respectively); missense rs2231142 in ABCG2 (p=2 times 5x10 super(-60) and 9 times 8x10 super(-4)), and rs1165205 in SLC17A3 (p=3 times 3x10 super(-26) and 0.33). All SNPs were direction-consistent with gout in white participants: rs16890979 (OR 0 times 59 per T allele, 95% CI 0 times 52-0.68, p=7 times 0x10 super(-14)), rs2231142 (1 times 74, 1 times 51-1 times 99, p=3 times 3x10 super(-15)), and rs1165205 (0 times 85, 0 times 77-0 times 94, p=0 times 002). In black partidpants of the ARIC study, rs2231142 was direction-consistent with gout (1 times 71, 1 times 06-2 times 77, p=0 times 028). An additive genetic risk score of high-risk alleles at the three loci showed graded associations with uric add (272-351 mu mol/L in the Framingham cohort, 269-386 mu mol/L in the Rotterdam cohort, and 303-426 mu mol/L in white participants of the ARIC study) and gout (frequency 2-13% in the Framingham cohort, 2-8% in the Rotterdam cohort, and 1-18% in white participants in the ARIC study). Interpretation We identified three genetic loci associated with uric add concentration and gout. A score based on genes with a putative role in renal urate handling showed a substantial risk for gout Funding Netherlands Organisation for Scientific Research (NWO); the National Heart, Lung, and Blood Institute. JF - Lancet AU - Dehghan, A AU - Koettgen, A AU - Yang, Q AU - Hwang, S-J AU - Kao, WHL AU - Rivadeneira, F AU - Boerwinkle, E AU - Levy, D AU - Hofman, A AU - Astor, B C AU - Benjamin, E J AU - van Duijn, CM AU - Wittemant, J C AU - Coresht, J AU - Foxt, C S AD - National Heart Lung and Blood Institute, the Framingham Heart Study, 73 Mount Wayte Avenue Suite 2, Framinqham, MA 01702, USA, foxca@nhlbi.nih.gov Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 1953 EP - 1961 VL - 372 IS - 9654 SN - 0140-6736, 0140-6736 KW - Genetics Abstracts; Risk Abstracts KW - Heart KW - Netherlands, Rotterdam KW - Gout KW - Blood KW - Renal function KW - Single-nucleotide polymorphism KW - Lung KW - Risk factors KW - Reviews KW - Kidney KW - Risk groups KW - Netherlands KW - Additives KW - Uric acid KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20734936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Association+of+three+genetic+loci+with+uric+acid+concentration+and+risk+of+gout%3A+a+genome-wide+association+study&rft.au=Dehghan%2C+A%3BKoettgen%2C+A%3BYang%2C+Q%3BHwang%2C+S-J%3BKao%2C+WHL%3BRivadeneira%2C+F%3BBoerwinkle%2C+E%3BLevy%2C+D%3BHofman%2C+A%3BAstor%2C+B+C%3BBenjamin%2C+E+J%3Bvan+Duijn%2C+CM%3BWittemant%2C+J+C%3BCoresht%2C+J%3BFoxt%2C+C+S&rft.aulast=Dehghan&rft.aufirst=A&rft.date=2008-12-12&rft.volume=372&rft.issue=9654&rft.spage=1953&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2808%2961343-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Blood; Renal function; Lung; Single-nucleotide polymorphism; Reviews; Risk factors; Kidney; Risk groups; Gout; Uric acid; Additives; Netherlands, Rotterdam; Netherlands DO - http://dx.doi.org/10.1016/S0140-6736(08)61343-4 ER - TY - JOUR T1 - The High-Resolution NMR Structure of the Early Folding Intermediate of the Thermus thermophilus Ribonuclease H AN - 19805151; 8851096 AB - Elucidation of the high-resolution structures of folding intermediates is a necessary but difficult step toward the ultimate understanding of the mechanism of protein folding. Here, using hydrogen-exchange-directed protein engineering, we populated the folding intermediate of the Thermus thermophilus ribonuclease H, which forms before the rate-limiting transition state, by removing the unfolded regions of the intermediate, including an a-helix and two b-strands (51 folded residues). Using multidimensional NMR, we solved the structure of this intermediate mimic to an atomic resolution (backbone rmsd, 0.51 A). It has a native-like backbone topology and shows some local deviations from the native structure, revealing that the structure of the folded region of an early folding intermediate can be as well defined as the native structure. The topological parameters calculated from the structures of the intermediate mimic and the native state predict that the intermediate should fold on a millisecond time scale or less and form much faster than the native state. Other factors that may lead to the slow folding of the native state and the accumulation of the intermediate before the rate-limiting transition state are also discussed. JF - Journal of Molecular Biology AU - Zhou, Z AU - Feng, H AU - Ghirlando, R AU - Bai, Y AD - National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, yawen@helix.nih.gov Y1 - 2008/12/12/ PY - 2008 DA - 2008 Dec 12 SP - 531 EP - 539 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 384 IS - 2 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; ASFA 1: Biological Sciences & Living Resources KW - Protein folding KW - Protein engineering KW - Biochemistry KW - Ribonuclease H KW - Microorganisms KW - N.M.R. KW - Thermus thermophilus KW - Q1 08206:Physiology, biochemistry, biophysics KW - J 02320:Cell Biology KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19805151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=The+High-Resolution+NMR+Structure+of+the+Early+Folding+Intermediate+of+the+Thermus+thermophilus+Ribonuclease+H&rft.au=Zhou%2C+Z%3BFeng%2C+H%3BGhirlando%2C+R%3BBai%2C+Y&rft.aulast=Zhou&rft.aufirst=Z&rft.date=2008-12-12&rft.volume=384&rft.issue=2&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2008.09.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Biochemistry; Microorganisms; Protein engineering; Protein folding; Ribonuclease H; N.M.R.; Thermus thermophilus DO - http://dx.doi.org/10.1016/j.jmb.2008.09.044 ER - TY - CPAPER T1 - An Improved Estimator of Variance Explained in the Presence of Noise T2 - Twenty-Second Annual Conference on Neural Information Processing Systems (NIPS 2008) AN - 41973843; 5130017 JF - Twenty-Second Annual Conference on Neural Information Processing Systems (NIPS 2008) AU - Haefner, Ralf AU - Cumming, Bruce Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41973843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Twenty-Second+Annual+Conference+on+Neural+Information+Processing+Systems+%28NIPS+2008%29&rft.atitle=An+Improved+Estimator+of+Variance+Explained+in+the+Presence+of+Noise&rft.au=Haefner%2C+Ralf%3BCumming%2C+Bruce&rft.aulast=Haefner&rft.aufirst=Ralf&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Twenty-Second+Annual+Conference+on+Neural+Information+Processing+Systems+%28NIPS+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://nips.cc/Conferences/2008/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Collaborative Learning by Boosting in Distributed Environments T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41721764; 4987087 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Wang, Shijun AU - Zhang, Changshui Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41721764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Collaborative+Learning+by+Boosting+in+Distributed+Environments&rft.au=Wang%2C+Shijun%3BZhang%2C+Changshui&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Anatomical Landmarks in Human Colon from Computed Tomographic Colonography Images T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41706111; 4986926 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Chowdhury, Ananda AU - Yao, Jianhua AU - Van Uitert, Robert AU - Linguraru, Marius AU - Summers, Ronald Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Colon KW - Computed tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41706111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Detection+of+Anatomical+Landmarks+in+Human+Colon+from+Computed+Tomographic+Colonography+Images&rft.au=Chowdhury%2C+Ananda%3BYao%2C+Jianhua%3BVan+Uitert%2C+Robert%3BLinguraru%2C+Marius%3BSummers%2C+Ronald&rft.aulast=Chowdhury&rft.aufirst=Ananda&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Matching Colonic Polyps from Prone and Supine CT Colonography Scans Based on Statistical Curvature Information T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41705364; 4986949 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Wang, Shijun AU - Yao, Jianhua AU - Summers, Ronald Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Polyps KW - Statistics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41705364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Matching+Colonic+Polyps+from+Prone+and+Supine+CT+Colonography+Scans+Based+on+Statistical+Curvature+Information&rft.au=Wang%2C+Shijun%3BYao%2C+Jianhua%3BSummers%2C+Ronald&rft.aulast=Wang&rft.aufirst=Shijun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cervicographic Image Retrieval by Spatial Similarity of Lesions T2 - 19th International Conference on Pattern Recognition (ICPR 2008) AN - 41656636; 4987455 JF - 19th International Conference on Pattern Recognition (ICPR 2008) AU - Xue, Zhiyun AU - Long, L AU - Antani, Sameer AU - Thoma, George AU - Jeronimo, Jose Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 KW - Lesions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41656636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.atitle=Cervicographic+Image+Retrieval+by+Spatial+Similarity+of+Lesions&rft.au=Xue%2C+Zhiyun%3BLong%2C+L%3BAntani%2C+Sameer%3BThoma%2C+George%3BJeronimo%2C+Jose&rft.aulast=Xue&rft.aufirst=Zhiyun&rft.date=2008-12-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+International+Conference+on+Pattern+Recognition+%28ICPR+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icpr2008.org/conference_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Urethane and N-nitrosodiethylamine are mutagenic for the Syrian hamster fetus AN - 19562292; 8800921 AB - Urethane and N-nitrosodiethylamine are soluble environmental carcinogens that initiate tumors transplacentally, but have a mixed history of effectiveness in mutagenesis assays in vitro or in vivo with adult rodents. To test for their transplacental mutagenicity, Syrian hamster fetuses at 12 days in gestation were exposed transplacentally to urethane or N-nitrosodiethylamine at 0.5 or 1.0mM/kg. The fetal cells were isolated on day 13 of gestation and tested for diphtheria toxin resistance as a mutation marker. Both compounds were significantly mutagenic, at both doses, causing 6- to 20-fold increases in mutations compared with controls. Compared with N-nitrosodiethylamine, urethane was somewhat more effective as a mutagen with a more marked dose-response. These results are consistent with mutagenesis as part of the mechanism of transplacental carcinogenicity of urethane and N-nitrosodiethylamine. JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Donovan, P J AU - Smith, G T AD - National Cancer Institute at Frederick, Building 538, Room 205 NCI-Frederick, Frederick, MD 21702-1201, USA, donovapa@mail.nih.gov Y1 - 2008/12/08/ PY - 2008 DA - 2008 Dec 08 SP - 160 EP - 163 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 657 IS - 2 SN - 1383-5718, 1383-5718 KW - Genetics Abstracts; Toxicology Abstracts KW - Mutagens KW - Mutagenicity KW - Tumors KW - Carcinogens KW - Fetuses KW - Diphtheria toxin KW - Mutagenesis KW - Carcinogenicity KW - Gestation KW - urethane KW - Mutation KW - N-Nitrosodiethylamine KW - X 24370:Natural Toxins KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19562292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Urethane+and+N-nitrosodiethylamine+are+mutagenic+for+the+Syrian+hamster+fetus&rft.au=Donovan%2C+P+J%3BSmith%2C+G+T&rft.aulast=Donovan&rft.aufirst=P&rft.date=2008-12-08&rft.volume=657&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2008.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mutagens; Mutagenicity; Carcinogenicity; Gestation; Carcinogens; Tumors; Mutation; urethane; Diphtheria toxin; Fetuses; N-Nitrosodiethylamine; Mutagenesis DO - http://dx.doi.org/10.1016/j.mrgentox.2008.07.011 ER - TY - CPAPER T1 - Biological Functions of Membrane-Type Matrix Metalloproteinases T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41899422; 5091696 JF - 2008 Meeting of the American Society for Matrix Biology AU - Holmbeck, Kenn Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Matrix metalloproteinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Biological+Functions+of+Membrane-Type+Matrix+Metalloproteinases&rft.au=Holmbeck%2C+Kenn&rft.aulast=Holmbeck&rft.aufirst=Kenn&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Early Inflammatory Response to Bites of Leishmania Major Infected Phlebotomus Duboscqi Sand Flies in NaiVe and Pre -Exposed Mice T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41897139; 5079979 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Teixeira, Clarissa AU - Oliveira, Luis AU - Gomes, Regis AU - Elnaiem, Dia AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Bites KW - Mice KW - Sand KW - Inflammation KW - Leishmania major KW - Phlebotomus duboscqi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41897139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Characterization+of+the+Early+Inflammatory+Response+to+Bites+of+Leishmania+Major+Infected+Phlebotomus+Duboscqi+Sand+Flies+in+NaiVe+and+Pre+-Exposed+Mice&rft.au=Teixeira%2C+Clarissa%3BOliveira%2C+Luis%3BGomes%2C+Regis%3BElnaiem%2C+Dia%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Teixeira&rft.aufirst=Clarissa&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discovery of Leishmania Parasite -Sandfly Interaction Targets for Transmission -Blocking and /or Sandfly -Killing Vaccines T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41896637; 5080273 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Vaccines KW - Disease control KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41896637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Discovery+of+Leishmania+Parasite+-Sandfly+Interaction+Targets+for+Transmission+-Blocking+and+%2For+Sandfly+-Killing+Vaccines&rft.au=Valenzuela%2C+Jesus&rft.aulast=Valenzuela&rft.aufirst=Jesus&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutual Stabilization of P3H1 and CRTAP in ER Modification Complex T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41888893; 5091903 JF - 2008 Meeting of the American Society for Matrix Biology AU - Chang, W AU - Barnes, A AU - Cabral, W AU - Marini, J Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Stabilizing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Mutual+Stabilization+of+P3H1+and+CRTAP+in+ER+Modification+Complex&rft.au=Chang%2C+W%3BBarnes%2C+A%3BCabral%2C+W%3BMarini%2C+J&rft.aulast=Chang&rft.aufirst=W&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Basement Membrane Remodeling During Branching Morphogenesis: The Dynamic Interplay of Proteolysis and Proliferation T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41888867; 5091735 JF - 2008 Meeting of the American Society for Matrix Biology AU - Hoffman, Matthew Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Membranes KW - Proteolysis KW - Morphogenesis KW - Basement membranes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41888867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Basement+Membrane+Remodeling+During+Branching+Morphogenesis%3A+The+Dynamic+Interplay+of+Proteolysis+and+Proliferation&rft.au=Hoffman%2C+Matthew&rft.aulast=Hoffman&rft.aufirst=Matthew&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Confocal Microscopy Study of Decorin Binding to Collagen Fibrils T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41885384; 5091897 JF - 2008 Meeting of the American Society for Matrix Biology AU - Makareeva, Elena AU - Sutter, Mary AU - DeRidder, Angela AU - Forlino, Antonella AU - Rossi, Antonio AU - Tenni, Ruggero AU - Leikin, Sergey Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Confocal microscopy KW - Decorin KW - Collagen KW - Fibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41885384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Confocal+Microscopy+Study+of+Decorin+Binding+to+Collagen+Fibrils&rft.au=Makareeva%2C+Elena%3BSutter%2C+Mary%3BDeRidder%2C+Angela%3BForlino%2C+Antonella%3BRossi%2C+Antonio%3BTenni%2C+Ruggero%3BLeikin%2C+Sergey&rft.aulast=Makareeva&rft.aufirst=Elena&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Institutes of Health /Fogarty International Center Support to Build Research Capacity T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41884910; 5079190 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sina, Barbara Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41884910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=National+Institutes+of+Health+%2FFogarty+International+Center+Support+to+Build+Research+Capacity&rft.au=Sina%2C+Barbara&rft.aulast=Sina&rft.aufirst=Barbara&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct OI Phenotype Caused by COL1 C-proteinase Site Mutations T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41877171; 5091868 JF - 2008 Meeting of the American Society for Matrix Biology AU - Barnes, A AU - Lindahl, K AU - Whyte, M AU - Hefferan, T AU - Rubin, C-J AU - Kindmark, A AU - McAlister, W AU - Mumm, S AU - Ljunggren, O AU - Marini, J Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mutation KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41877171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Distinct+OI+Phenotype+Caused+by+COL1+C-proteinase+Site+Mutations&rft.au=Barnes%2C+A%3BLindahl%2C+K%3BWhyte%2C+M%3BHefferan%2C+T%3BRubin%2C+C-J%3BKindmark%2C+A%3BMcAlister%2C+W%3BMumm%2C+S%3BLjunggren%2C+O%3BMarini%2C+J&rft.aulast=Barnes&rft.aufirst=A&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DMP1 Isoforms Promote Differential Cell Attachment and Migration T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41873107; 5091703 JF - 2008 Meeting of the American Society for Matrix Biology AU - von Marschall, Zofia Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Migration KW - Cell adhesion KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41873107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=DMP1+Isoforms+Promote+Differential+Cell+Attachment+and+Migration&rft.au=von+Marschall%2C+Zofia&rft.aulast=von+Marschall&rft.aufirst=Zofia&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building Research and Human Capacity One Link at a Time : the National Library of Medicine 's International Information Interventions T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872876; 5080194 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Royall, Julia Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Building+Research+and+Human+Capacity+One+Link+at+a+Time+%3A+the+National+Library+of+Medicine+%27s+International+Information+Interventions&rft.au=Royall%2C+Julia&rft.aulast=Royall&rft.aufirst=Julia&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of Invasive Long Lived Plasmodium Falciparum Merozoites by Cell Sieving T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872465; 5079893 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Narum, David AU - Haynes, J AU - Moch, J AU - Dutta, Sheetij Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Merozoites KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Isolation+of+Invasive+Long+Lived+Plasmodium+Falciparum+Merozoites+by+Cell+Sieving&rft.au=Narum%2C+David%3BHaynes%2C+J%3BMoch%2C+J%3BDutta%2C+Sheetij&rft.aulast=Narum&rft.aufirst=David&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Post -treatment reactions in loiasis : looking towards the future T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41872284; 5079845 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Klion, Amy Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41872284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Post+-treatment+reactions+in+loiasis+%3A+looking+towards+the+future&rft.au=Klion%2C+Amy&rft.aulast=Klion&rft.aufirst=Amy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complexity of the Tick Salivary Gland Transcriptome and Proteome T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41871969; 5079779 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ribeiro, Jose Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Gene expression KW - Salivary gland KW - Glands KW - Ixodidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41871969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Complexity+of+the+Tick+Salivary+Gland+Transcriptome+and+Proteome&rft.au=Ribeiro%2C+Jose&rft.aulast=Ribeiro&rft.aufirst=Jose&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thrombospondin-1 Regulates Blood Pressure and Cardiac Response T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41871555; 5091823 JF - 2008 Meeting of the American Society for Matrix Biology AU - Isenberg, Jeff AU - Qin, Yan AU - Despres, Daryl AU - Bandle, Russell AU - Schnermann, Jurgen AU - Frazier, William AU - Roberts, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Thrombospondin KW - Blood pressure KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41871555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Thrombospondin-1+Regulates+Blood+Pressure+and+Cardiac+Response&rft.au=Isenberg%2C+Jeff%3BQin%2C+Yan%3BDespres%2C+Daryl%3BBandle%2C+Russell%3BSchnermann%2C+Jurgen%3BFrazier%2C+William%3BRoberts%2C+David&rft.aulast=Isenberg&rft.aufirst=Jeff&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Anti -ama1 Antibodies Induced by ama1-c2, a Three -Allele Combination Vaccine T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41868786; 5078727 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Murray, Sara AU - Zhou, Hong AU - Aebig, Joan AU - Lambert, Lynn AU - Martin, Laura AU - Miller, Louis AU - Long, Carole AU - Miura, Kazutoyo Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Antibodies KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Characterization+of+Anti+-ama1+Antibodies+Induced+by+ama1-c2%2C+a+Three+-Allele+Combination+Vaccine&rft.au=Murray%2C+Sara%3BZhou%2C+Hong%3BAebig%2C+Joan%3BLambert%2C+Lynn%3BMartin%2C+Laura%3BMiller%2C+Louis%3BLong%2C+Carole%3BMiura%2C+Kazutoyo&rft.aulast=Murray&rft.aufirst=Sara&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of a Serine Protease from A. Gambiae in Plasmodium Development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41868573; 5079614 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rodrigues, Janneth AU - Abban, Ekua AU - Ortega, Corrie AU - Molina-Cruz, Alvaro AU - Barillas Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Serine proteinase KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41868573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Role+of+a+Serine+Protease+from+A.+Gambiae+in+Plasmodium+Development&rft.au=Rodrigues%2C+Janneth%3BAbban%2C+Ekua%3BOrtega%2C+Corrie%3BMolina-Cruz%2C+Alvaro%3BBarillas+Mury%2C+Carolina&rft.aulast=Rodrigues&rft.aufirst=Janneth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro Assessment of Taenia crassiceps Motility and its Application to the Study of Anthelmintic Treatment in Neurocysticercosis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41867556; 5078802 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Scott, Erick AU - Kabat, Juraj AU - Schwartz, Owen AU - Nash, Theodore AU - Mahanty, Siddhartha Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Motility KW - Cysticercosis KW - Taenia KW - Taenia crassiceps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=In+vitro+Assessment+of+Taenia+crassiceps+Motility+and+its+Application+to+the+Study+of+Anthelmintic+Treatment+in+Neurocysticercosis&rft.au=Scott%2C+Erick%3BKabat%2C+Juraj%3BSchwartz%2C+Owen%3BNash%2C+Theodore%3BMahanty%2C+Siddhartha&rft.aulast=Scott&rft.aufirst=Erick&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Profiling protective humoral immune responses to Plasmodium falciparum by protein microarray in a longitudinal study in Mali T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41867131; 5079544 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Crompton, Peter AU - Kayala, Matt AU - Traore, Boubacar AU - Weiss, Greta AU - Burk, Chad AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Doumbo, Safiatou AU - Miller, Louis AU - Doumbo, Ogobara AU - Doolan, Denise AU - Baldi, Pierre AU - Felgner, Philip AU - Pierce, Susan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Longitudinal studies KW - Protein arrays KW - Immune response (humoral) KW - Parasites KW - Profiling KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41867131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Profiling+protective+humoral+immune+responses+to+Plasmodium+falciparum+by+protein+microarray+in+a+longitudinal+study+in+Mali&rft.au=Crompton%2C+Peter%3BKayala%2C+Matt%3BTraore%2C+Boubacar%3BWeiss%2C+Greta%3BBurk%2C+Chad%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BDoumbo%2C+Safiatou%3BMiller%2C+Louis%3BDoumbo%2C+Ogobara%3BDoolan%2C+Denise%3BBaldi%2C+Pierre%3BFelgner%2C+Philip%3BPierce%2C+Susan&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The impact of access to primary health care on the incidence of clinical malaria in children T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41861292; 5079540 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - O'Meara, Wendy AU - Noor, Abdisalan AU - Tsofa, Benjamin AU - McKenzie, F AU - Marsh, Kevin Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Children KW - Malaria KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41861292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+impact+of+access+to+primary+health+care+on+the+incidence+of+clinical+malaria+in+children&rft.au=O%27Meara%2C+Wendy%3BNoor%2C+Abdisalan%3BTsofa%2C+Benjamin%3BMcKenzie%2C+F%3BMarsh%2C+Kevin&rft.aulast=O%27Meara&rft.aufirst=Wendy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and molecular cataloging of hemocyte specific immune genes from malaria vector A. gambiae T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41860759; 5080128 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Dixit, Rajnikant AU - Kumar, Sanjeev AU - Gupta, Lalita AU - Molina-Cruz, Alvaro AU - Rodrigues, Janneth AU - Valenzuela, Jesus AU - Ribeiro, Jose AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Malaria KW - Vectors KW - Hemocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Identification+and+molecular+cataloging+of+hemocyte+specific+immune+genes+from+malaria+vector+A.+gambiae&rft.au=Dixit%2C+Rajnikant%3BKumar%2C+Sanjeev%3BGupta%2C+Lalita%3BMolina-Cruz%2C+Alvaro%3BRodrigues%2C+Janneth%3BValenzuela%2C+Jesus%3BRibeiro%2C+Jose%3BBarillas-Mury%2C+Carolina&rft.aulast=Dixit&rft.aufirst=Rajnikant&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Does Plasmodium Evade the Mosquito 'S Immune System ? T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41860423; 5079240 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immune system KW - Aquatic insects KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41860423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=How+Does+Plasmodium+Evade+the+Mosquito+%27S+Immune+System+%3F&rft.au=Barillas-Mury%2C+Carolina&rft.aulast=Barillas-Mury&rft.aufirst=Carolina&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MSCs create a TIMP-rich, matrix-protective local environment T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41859176; 5091830 JF - 2008 Meeting of the American Society for Matrix Biology AU - Lozito, Thomas AU - White, Cassie AU - Kuo, Catherine AU - Taboas, Juan AU - Tuan, Rocky Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=MSCs+create+a+TIMP-rich%2C+matrix-protective+local+environment&rft.au=Lozito%2C+Thomas%3BWhite%2C+Cassie%3BKuo%2C+Catherine%3BTaboas%2C+Juan%3BTuan%2C+Rocky&rft.aulast=Lozito&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ECMPs act as centers of MMP activation and matrix remodeling T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41859135; 5091829 JF - 2008 Meeting of the American Society for Matrix Biology AU - Lozito, Thomas AU - White, Cassie AU - Kuo, Catherine AU - Taboas, Juan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41859135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=ECMPs+act+as+centers+of+MMP+activation+and+matrix+remodeling&rft.au=Lozito%2C+Thomas%3BWhite%2C+Cassie%3BKuo%2C+Catherine%3BTaboas%2C+Juan&rft.aulast=Lozito&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Humans from an endemic area of cutaneous leishmaniasis in Mali produce IFN-gamma to sand fly salivary proteins T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857936; 5079924 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Oliveira, Fabiano AU - Gomes, Regis AU - Teixeira, Clarissa AU - Faye, Ousmane AU - Traore, Pierre AU - Diarra, Souleymane AU - Anderson, Jeniffer AU - Dia-Eldin, Elnaiem AU - Samake, Sibiry AU - Traore, Bourama AU - Coulibaly, Cheick AU - Rick, Fairhurst AU - Keita, Somita AU - Doumbia, Seydou AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Sand KW - G-Interferon KW - Cutaneous leishmaniasis KW - Endemic species KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Humans+from+an+endemic+area+of+cutaneous+leishmaniasis+in+Mali+produce+IFN-gamma+to+sand+fly+salivary+proteins&rft.au=Oliveira%2C+Fabiano%3BGomes%2C+Regis%3BTeixeira%2C+Clarissa%3BFaye%2C+Ousmane%3BTraore%2C+Pierre%3BDiarra%2C+Souleymane%3BAnderson%2C+Jeniffer%3BDia-Eldin%2C+Elnaiem%3BSamake%2C+Sibiry%3BTraore%2C+Bourama%3BCoulibaly%2C+Cheick%3BRick%2C+Fairhurst%3BKeita%2C+Somita%3BDoumbia%2C+Seydou%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Oliveira&rft.aufirst=Fabiano&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loa loa : a clinical overview T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857790; 5079842 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Loa+loa+%3A+a+clinical+overview&rft.au=Nutman%2C+Thomas&rft.aulast=Nutman&rft.aufirst=Thomas&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lutzomyia longipalpis recombinant salivary yellow -related protein (LJM11) confers protection against leishmania infected sand flies T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857775; 5079976 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Gomes, Regis AU - Oliveira, Fabiano AU - Teixeira, Clarissa AU - Elnaiem, Dia-Eldin AU - Kamhawi, Shaden AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Sand KW - Recombinants KW - Lutzomyia longipalpis KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Lutzomyia+longipalpis+recombinant+salivary+yellow+-related+protein+%28LJM11%29+confers+protection+against+leishmania+infected+sand+flies&rft.au=Gomes%2C+Regis%3BOliveira%2C+Fabiano%3BTeixeira%2C+Clarissa%3BElnaiem%2C+Dia-Eldin%3BKamhawi%2C+Shaden%3BValenzuela%2C+Jesus&rft.aulast=Gomes&rft.aufirst=Regis&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Type I collagen homotrimers may alter tissue remodeling T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41857730; 5091809 JF - 2008 Meeting of the American Society for Matrix Biology AU - Han, Sejin AU - Makareeva, Elena AU - McBride, Daniel AU - Phillips, Charlotte AU - Schwarze, Ulrike AU - Pace, James AU - Byers, Peter AU - Visse, Robert AU - Nagase, Hideaki AU - Leikin, Sergey Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Collagen (type I) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Type+I+collagen+homotrimers+may+alter+tissue+remodeling&rft.au=Han%2C+Sejin%3BMakareeva%2C+Elena%3BMcBride%2C+Daniel%3BPhillips%2C+Charlotte%3BSchwarze%2C+Ulrike%3BPace%2C+James%3BByers%2C+Peter%3BVisse%2C+Robert%3BNagase%2C+Hideaki%3BLeikin%2C+Sergey&rft.aulast=Han&rft.aufirst=Sejin&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A tep1 Mediated Response Is Required but Not Sufficient for Melanization of Plasmodium Falciprum in the Anopheles Gambiae Midgut T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857482; 5080283 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Molina-Cruz, Alvaro AU - Ortega, Corrie AU - DeJong, Randall AU - Rodrigues, Janneth AU - Jaramillo-Gutierrez, Giovanna AU - Abban, Ekua AU - Barillas-Mury, Carolina Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Midgut KW - Melanization KW - Aquatic insects KW - Plasmodium KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+tep1+Mediated+Response+Is+Required+but+Not+Sufficient+for+Melanization+of+Plasmodium+Falciprum+in+the+Anopheles+Gambiae+Midgut&rft.au=Molina-Cruz%2C+Alvaro%3BOrtega%2C+Corrie%3BDeJong%2C+Randall%3BRodrigues%2C+Janneth%3BJaramillo-Gutierrez%2C+Giovanna%3BAbban%2C+Ekua%3BBarillas-Mury%2C+Carolina&rft.aulast=Molina-Cruz&rft.aufirst=Alvaro&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing the correlation between Growth Inhibition activity and malaria risk in a longitudinal study in Mali T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41857209; 5079543 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Crompton, Peter AU - Miura, Kazutoyo AU - Traore, Boubacar AU - Kayentao, Kassoum AU - Ongoiba, Aissata AU - Weiss, Greta AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Huang, Chiung-Yu AU - Doumbo, Ogobara AU - Miller, Louis AU - Long, Carole AU - Pierce, Susan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mali KW - Longitudinal studies KW - Malaria KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41857209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Assessing+the+correlation+between+Growth+Inhibition+activity+and+malaria+risk+in+a+longitudinal+study+in+Mali&rft.au=Crompton%2C+Peter%3BMiura%2C+Kazutoyo%3BTraore%2C+Boubacar%3BKayentao%2C+Kassoum%3BOngoiba%2C+Aissata%3BWeiss%2C+Greta%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BHuang%2C+Chiung-Yu%3BDoumbo%2C+Ogobara%3BMiller%2C+Louis%3BLong%2C+Carole%3BPierce%2C+Susan&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extracellular Matrix Control of Stem Cell Niches T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41856585; 5091682 JF - 2008 Meeting of the American Society for Matrix Biology AU - Young, Marian Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Stem cells KW - Niches KW - Extracellular matrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Extracellular+Matrix+Control+of+Stem+Cell+Niches&rft.au=Young%2C+Marian&rft.aulast=Young&rft.aufirst=Marian&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neutrophils Are the Predominant Initial Host Cell for Leishmania Major and Are Essential for the Establishment of Sand Fly Transmitted Infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41856528; 5080344 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Peters, Nathan AU - Egen, Jackson AU - Secundino, Naglia AU - Debrabant, Alain AU - Kimblin, Nicola AU - Kamhawi, Shaden AU - Lawyer, Phillip AU - Germain, Ronald AU - Sacks, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Sand KW - Leukocytes (neutrophilic) KW - Leishmania major KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Neutrophils+Are+the+Predominant+Initial+Host+Cell+for+Leishmania+Major+and+Are+Essential+for+the+Establishment+of+Sand+Fly+Transmitted+Infection&rft.au=Peters%2C+Nathan%3BEgen%2C+Jackson%3BSecundino%2C+Naglia%3BDebrabant%2C+Alain%3BKimblin%2C+Nicola%3BKamhawi%2C+Shaden%3BLawyer%2C+Phillip%3BGermain%2C+Ronald%3BSacks%2C+David&rft.aulast=Peters&rft.aufirst=Nathan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide Depletion and Endothelial Dysfunction in Children with Malaria and Marked Anemia T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41856365; 5080320 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Janka, Jacqueline AU - Koita, Ousmane AU - Josepha, Maya AU - Traore, Broulaye AU - Mzayek, Fawaz AU - Sangare, Lansana AU - Cisse, Ousmane AU - Mendelsohn, Laurel AU - Wang, Xunde AU - Masur, Henry AU - Gladwin, Mark AU - Krogstad, Donald Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Anemia KW - Children KW - Malaria KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41856365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Nitric+Oxide+Depletion+and+Endothelial+Dysfunction+in+Children+with+Malaria+and+Marked+Anemia&rft.au=Janka%2C+Jacqueline%3BKoita%2C+Ousmane%3BJosepha%2C+Maya%3BTraore%2C+Broulaye%3BMzayek%2C+Fawaz%3BSangare%2C+Lansana%3BCisse%2C+Ousmane%3BMendelsohn%2C+Laurel%3BWang%2C+Xunde%3BMasur%2C+Henry%3BGladwin%2C+Mark%3BKrogstad%2C+Donald&rft.aulast=Janka&rft.aufirst=Jacqueline&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of human H5N1 disease in SEA with emphasis on epidemiology and clinical outcomes in H5N1 T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855255; 5079876 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sedyaningsih, Endang Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Reviews KW - Epidemiology KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Overview+of+human+H5N1+disease+in+SEA+with+emphasis+on+epidemiology+and+clinical+outcomes+in+H5N1&rft.au=Sedyaningsih%2C+Endang&rft.aulast=Sedyaningsih&rft.aufirst=Endang&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of IgM capture ELISA assays for the detection anti -JEV IgM antibodies in cerebrospinal fluid samples T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855101; 5079828 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Vasanthapuram, Ravi AU - Robinson, Jamie AU - Russell, Brandy AU - Desai, Anita AU - Ramamurty, Nalini AU - Featherstone, David AU - Johnson, Barbara Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immunoglobulin M KW - Cerebrospinal fluid KW - ELISA KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Evaluation+of+IgM+capture+ELISA+assays+for+the+detection+anti+-JEV+IgM+antibodies+in+cerebrospinal+fluid+samples&rft.au=Vasanthapuram%2C+Ravi%3BRobinson%2C+Jamie%3BRussell%2C+Brandy%3BDesai%2C+Anita%3BRamamurty%2C+Nalini%3BFeatherstone%2C+David%3BJohnson%2C+Barbara&rft.aulast=Vasanthapuram&rft.aufirst=Ravi&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The role of human dendritic cells in filarial infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41855048; 5079815 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Semnani, Roshanak Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41855048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+role+of+human+dendritic+cells+in+filarial+infection&rft.au=Semnani%2C+Roshanak&rft.aulast=Semnani&rft.aufirst=Roshanak&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Roles of Plasmodium Rhomboid 1 in Parasite Development and Malaria Pathogenesis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41854710; 5078661 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Srinivasan, Prakash AU - Coppens, Isabelle AU - Jacobs-Lorena, Marcelo Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Malaria KW - Public health KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41854710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Distinct+Roles+of+Plasmodium+Rhomboid+1+in+Parasite+Development+and+Malaria+Pathogenesis&rft.au=Srinivasan%2C+Prakash%3BCoppens%2C+Isabelle%3BJacobs-Lorena%2C+Marcelo&rft.aulast=Srinivasan&rft.aufirst=Prakash&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of miRNAs that regulate epithelial morphogenesis during submandibular gland development T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41853541; 5091936 JF - 2008 Meeting of the American Society for Matrix Biology AU - Rebustini, I AU - Reynolds, A AU - Hoffman, M Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - MiRNA KW - Submandibular gland KW - Morphogenesis KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=Identification+of+miRNAs+that+regulate+epithelial+morphogenesis+during+submandibular+gland+development&rft.au=Rebustini%2C+I%3BReynolds%2C+A%3BHoffman%2C+M&rft.aulast=Rebustini&rft.aufirst=I&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/2008%20ASMB%20Addendum.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Phase 1 study of the blood stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41852912; 5079565 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ellis, Ruth AU - Martin, Laura AU - Pierce, Mark AU - Miura, Kazutoyo AU - Mullen, Gregory AU - Fay, Michael AU - Long, Carole AU - Shaffer, Donna AU - Saul, Allan AU - Miller, Louis AU - Durbin, Anna Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Blood KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Phase+1+study+of+the+blood+stage+malaria+vaccine+candidate+AMA1-C1%2FAlhydrogel+with+CPG+7909%2C+using+two+different+formulations+and+dosing+intervals&rft.au=Ellis%2C+Ruth%3BMartin%2C+Laura%3BPierce%2C+Mark%3BMiura%2C+Kazutoyo%3BMullen%2C+Gregory%3BFay%2C+Michael%3BLong%2C+Carole%3BShaffer%2C+Donna%3BSaul%2C+Allan%3BMiller%2C+Louis%3BDurbin%2C+Anna&rft.aulast=Ellis&rft.aufirst=Ruth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Filarial lymphatic pathology is characterized by augmented pro -inflammatory cytokine production in response to TLR2 and TLR9 ligands T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41852677; 5079275 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Babu, Subash AU - Bhat, Sajid AU - Kumar, Pavan AU - Kolappan, C AU - Kumaraswami, V AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Pathology KW - Toll-like receptors KW - TLR2 protein KW - Cytokines KW - TLR9 protein KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41852677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Filarial+lymphatic+pathology+is+characterized+by+augmented+pro+-inflammatory+cytokine+production+in+response+to+TLR2+and+TLR9+ligands&rft.au=Babu%2C+Subash%3BBhat%2C+Sajid%3BKumar%2C+Pavan%3BKolappan%2C+C%3BKumaraswami%2C+V%3BNutman%2C+Thomas&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Alum Formulation Immunoassay (Dafia): An Immunofluorescent Assay That Directly Determines the Content , Identity and Integrity of Antigens Formulated on Alhydrogel T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851905; 5080105 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Zhu, Daming AU - Huang, Shuhui AU - Gebregeorgis, Elizabeth AU - McClellan, Holly AU - Miller, Louis AU - Saul, Allan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Immunoassays KW - Aluminum sulfate KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Direct+Alum+Formulation+Immunoassay+%28Dafia%29%3A+An+Immunofluorescent+Assay+That+Directly+Determines+the+Content+%2C+Identity+and+Integrity+of+Antigens+Formulated+on+Alhydrogel&rft.au=Zhu%2C+Daming%3BHuang%2C+Shuhui%3BGebregeorgis%2C+Elizabeth%3BMcClellan%2C+Holly%3BMiller%2C+Louis%3BSaul%2C+Allan&rft.aulast=Zhu&rft.aufirst=Daming&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions of Yersinia Pestis with Its Flea Vector That Underlie Stable Plague Transmission Cycles T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851447; 5080267 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Hinnebusch, B Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Disease transmission KW - Vectors KW - Plague KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Interactions+of+Yersinia+Pestis+with+Its+Flea+Vector+That+Underlie+Stable+Plague+Transmission+Cycles&rft.au=Hinnebusch%2C+B&rft.aulast=Hinnebusch&rft.aufirst=B&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Phase 1 Trial of the Malaria Transmission Blocking Vaccine Candidates Pfs 25 and Pvs 25 formulated with Montanide ISA 51 T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41851443; 5078780 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ellis, Ruth AU - Wu, Yimin AU - Shaffer, Donna AU - Fontes, Erica AU - Malkin, Elissa AU - Mahanty, Siddhartha AU - Fay, Michael AU - Narum, David AU - Rausch, Kelly AU - Miles, Aaron AU - Aebig, Joan AU - Orcutt, Andrew AU - Muratova, Olga AU - Song, Guanhong AU - Lambert, Lynn AU - Zhu, Daming AU - Miura, Kazutoyo AU - Long, Carole AU - Saul, Allan AU - Miller, Louis AU - Durbin, Anna Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Disease transmission KW - Malaria KW - Fish diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Phase+1+Trial+of+the+Malaria+Transmission+Blocking+Vaccine+Candidates+Pfs+25+and+Pvs+25+formulated+with+Montanide+ISA+51&rft.au=Ellis%2C+Ruth%3BWu%2C+Yimin%3BShaffer%2C+Donna%3BFontes%2C+Erica%3BMalkin%2C+Elissa%3BMahanty%2C+Siddhartha%3BFay%2C+Michael%3BNarum%2C+David%3BRausch%2C+Kelly%3BMiles%2C+Aaron%3BAebig%2C+Joan%3BOrcutt%2C+Andrew%3BMuratova%2C+Olga%3BSong%2C+Guanhong%3BLambert%2C+Lynn%3BZhu%2C+Daming%3BMiura%2C+Kazutoyo%3BLong%2C+Carole%3BSaul%2C+Allan%3BMiller%2C+Louis%3BDurbin%2C+Anna&rft.aulast=Ellis&rft.aufirst=Ruth&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatio-temporal ordering of a Chagas disease vector elimination campaign T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41850661; 5079730 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Levy, Michael AU - Malaga, Fernando AU - Cornejo del Carpio, Juan AU - McKenzie, Ellis AU - Plotkin, Joshua Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Chagas' disease KW - Disease transmission KW - Hosts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41850661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Spatio-temporal+ordering+of+a+Chagas+disease+vector+elimination+campaign&rft.au=Levy%2C+Michael%3BMalaga%2C+Fernando%3BCornejo+del+Carpio%2C+Juan%3BMcKenzie%2C+Ellis%3BPlotkin%2C+Joshua&rft.aulast=Levy&rft.aufirst=Michael&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation technologies for malaria vaccine development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41849196; 5079699 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Long, Carole Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Technology KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Evaluation+technologies+for+malaria+vaccine+development&rft.au=Long%2C+Carole&rft.aulast=Long&rft.aufirst=Carole&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Frequency of Drug Resistance Mutations in dhfr, dhps , and pfcrt, on the Pacific Coast of Peru T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41849029; 5080084 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Arrospide, Nancy AU - Gutierrez, Sonia AU - Marquino, Wilmer AU - Ruebush, Trent Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Peru KW - Pacific KW - Mutation KW - Coastal zone KW - Drug resistance KW - Dihydrofolate reductase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41849029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+Frequency+of+Drug+Resistance+Mutations+in+dhfr%2C+dhps+%2C+and+pfcrt%2C+on+the+Pacific+Coast+of+Peru&rft.au=Arrospide%2C+Nancy%3BGutierrez%2C+Sonia%3BMarquino%2C+Wilmer%3BRuebush%2C+Trent&rft.aulast=Arrospide&rft.aufirst=Nancy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anti -Apical Membrane Antigen 1 Igg Is More Effective in Inhibiting Plasmodium Falciparum Growth as Measured by in Vitro Growth Inhibition Assay than Anti -Merozoite Surface Protein 1 42 Igg T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41848731; 5079575 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Miura, Kazutoyo AU - Zhou, Hong AU - Diouf, Ababacar AU - Moretz, Samuel AU - Miller, Louis AU - Martin, Laura AU - Mullen, Gregory AU - Long, Carole Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Membranes KW - Immunoglobulin G KW - Growth KW - Parasites KW - Antigens KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Anti+-Apical+Membrane+Antigen+1+Igg+Is+More+Effective+in+Inhibiting+Plasmodium+Falciparum+Growth+as+Measured+by+in+Vitro+Growth+Inhibition+Assay+than+Anti+-Merozoite+Surface+Protein+1+42+Igg&rft.au=Miura%2C+Kazutoyo%3BZhou%2C+Hong%3BDiouf%2C+Ababacar%3BMoretz%2C+Samuel%3BMiller%2C+Louis%3BMartin%2C+Laura%3BMullen%2C+Gregory%3BLong%2C+Carole&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative analysis of malaria vaccine candidate AMA1-C1/Alhydrogel with the addition of unique CpG sequences T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41848654; 5079568 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rausch, Kelly AU - Ramineni, Bhanumati AU - Lambert, Lynn AU - Miura, Kazutoyo AU - Barnafo, Emma AU - Long, Carole AU - Miller, Louis AU - Martin, Laura Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Comparative+analysis+of+malaria+vaccine+candidate+AMA1-C1%2FAlhydrogel+with+the+addition+of+unique+CpG+sequences&rft.au=Rausch%2C+Kelly%3BRamineni%2C+Bhanumati%3BLambert%2C+Lynn%3BMiura%2C+Kazutoyo%3BBarnafo%2C+Emma%3BLong%2C+Carole%3BMiller%2C+Louis%3BMartin%2C+Laura&rft.aulast=Rausch&rft.aufirst=Kelly&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of TRAIL- and TNF-?-dependent apoptotic cell death in human monocyte -derived dendritic cells by Brugia malayi T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41847988; 5079273 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Semnani, Roshanak AU - Venugopal, Priyanka AU - Mahapatra, Lily AU - Skinner, Jason AU - Meylan, Francoise AU - Chaussabel, Damien AU - Siegel, Richard AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Mortality KW - Cell death KW - Dendritic cells KW - Apoptosis KW - Monocytes KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Induction+of+TRAIL-+and+TNF-%3F-dependent+apoptotic+cell+death+in+human+monocyte+-derived+dendritic+cells+by+Brugia+malayi&rft.au=Semnani%2C+Roshanak%3BVenugopal%2C+Priyanka%3BMahapatra%2C+Lily%3BSkinner%2C+Jason%3BMeylan%2C+Francoise%3BChaussabel%2C+Damien%3BSiegel%2C+Richard%3BNutman%2C+Thomas&rft.aulast=Semnani&rft.aufirst=Roshanak&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of acute Plasmodium vivax malaria with PyramaxRG (pyronaridine tetraphosphate /artesunate ) in a controlled Phase III clinical trial T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41847461; 5079923 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Tjitra, Emiliana AU - Ruangweerayut, Ronnatrai AU - Socheat, Duong AU - Valecha, Neena Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Clinical trials KW - Malaria KW - Artesunate KW - Pyronaridine KW - Public health KW - Plasmodium vivax KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41847461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Treatment+of+acute+Plasmodium+vivax+malaria+with+PyramaxRG+%28pyronaridine+tetraphosphate+%2Fartesunate+%29+in+a+controlled+Phase+III+clinical+trial&rft.au=Tjitra%2C+Emiliana%3BRuangweerayut%2C+Ronnatrai%3BSocheat%2C+Duong%3BValecha%2C+Neena&rft.aulast=Tjitra&rft.aufirst=Emiliana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in Exposure and Chronicity in Human Filarial Infection Leads to Variable Gene Expression Profiles T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846931; 5078917 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Steel, Cathy AU - Myers, Timothy AU - Su, Qin AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Differences+in+Exposure+and+Chronicity+in+Human+Filarial+Infection+Leads+to+Variable+Gene+Expression+Profiles&rft.au=Steel%2C+Cathy%3BMyers%2C+Timothy%3BSu%2C+Qin%3BNutman%2C+Thomas&rft.aulast=Steel&rft.aufirst=Cathy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Disruption of a Mechanosensitive Ion Channel in Plasmodium Falciparum T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846205; 5078995 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Rayavara, Kempaiah AU - Desai, Sanjay Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Channels KW - Ion channels KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Genetic+Disruption+of+a+Mechanosensitive+Ion+Channel+in+Plasmodium+Falciparum&rft.au=Rayavara%2C+Kempaiah%3BDesai%2C+Sanjay&rft.aulast=Rayavara&rft.aufirst=Kempaiah&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Neonatal Murine Model of Enteroaggregative Escherichia coli Infection T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41846197; 5078878 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Cabal, Ace AU - Roche, James AU - Sevilleja, Jesus AU - Nataro, James AU - Guerrant, Richard Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Neonates KW - Animal models KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+Novel+Neonatal+Murine+Model+of+Enteroaggregative+Escherichia+coli+Infection&rft.au=Cabal%2C+Ace%3BRoche%2C+James%3BSevilleja%2C+Jesus%3BNataro%2C+James%3BGuerrant%2C+Richard&rft.aulast=Cabal&rft.aufirst=Ace&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Carrier Frequency for Recessive OI in West Africans T2 - 2008 Meeting of the American Society for Matrix Biology AN - 41844241; 5091781 JF - 2008 Meeting of the American Society for Matrix Biology AU - Cabral, Wayne AU - Barnes, Aileen AU - Rotimi, Charles AU - Brody, Lawrence AU - Bailey-Wilson, Joan AU - Panny, Susan AU - Chitayat, David AU - Porter, Forbes AU - Marini, Joan Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Africa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41844241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.atitle=High+Carrier+Frequency+for+Recessive+OI+in+West+Africans&rft.au=Cabral%2C+Wayne%3BBarnes%2C+Aileen%3BRotimi%2C+Charles%3BBrody%2C+Lawrence%3BBailey-Wilson%2C+Joan%3BPanny%2C+Susan%3BChitayat%2C+David%3BPorter%2C+Forbes%3BMarini%2C+Joan&rft.aulast=Cabral&rft.aufirst=Wayne&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+Meeting+of+the+American+Society+for+Matrix+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.asmb.net/2008meeting/Official%202008%20ASMB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the barriers preventing successful development of Plasmodium falciparum in Culex mosquitoes T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41840855; 5079693 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Hume, Jen AU - Lehmann, Tovi Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Aquatic insects KW - Parasites KW - Barriers KW - Plasmodium falciparum KW - Culex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41840855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Identification+of+the+barriers+preventing+successful+development+of+Plasmodium+falciparum+in+Culex+mosquitoes&rft.au=Hume%2C+Jen%3BLehmann%2C+Tovi&rft.aulast=Hume&rft.aufirst=Jen&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Drug Resistance Using Plasmodium Falciparum Genetic Crosses T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839959; 5079738 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Sa, Juliana AU - Twu, Olivia AU - Hayton, Karen AU - Ringwald, Pascal AU - Wellems, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Drug resistance KW - Parasites KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Analysis+of+Drug+Resistance+Using+Plasmodium+Falciparum+Genetic+Crosses&rft.au=Sa%2C+Juliana%3BTwu%2C+Olivia%3BHayton%2C+Karen%3BRingwald%2C+Pascal%3BWellems%2C+Thomas&rft.aulast=Sa&rft.aufirst=Juliana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adjuvants and other immunopotentiators for malaria vaccine development T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839752; 5079701 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Seder, Robert Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Adjuvants KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Adjuvants+and+other+immunopotentiators+for+malaria+vaccine+development&rft.au=Seder%2C+Robert&rft.aulast=Seder&rft.aufirst=Robert&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccination with MSP142-C1/Alhydrogel RG generates antigen -specific memory B cells in malaria -naive U.S. adults and the CpG 7909 oligodeoxynucleotide adjuvant enhances this response T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41839143; 5079546 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Mircetic, Marko AU - Weiss, Greta AU - Mullen, Gregory AU - Martin, Laura AU - Miller, Louis AU - Pierce, Susan AU - Crompton, Peter Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - USA KW - Malaria KW - Lymphocytes B KW - Memory cells KW - Vaccination KW - Oligonucleotides KW - Immunological memory KW - Adjuvants KW - CpG islands KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Vaccination+with+MSP142-C1%2FAlhydrogel+RG+generates+antigen+-specific+memory+B+cells+in+malaria+-naive+U.S.+adults+and+the+CpG+7909+oligodeoxynucleotide+adjuvant+enhances+this+response&rft.au=Mircetic%2C+Marko%3BWeiss%2C+Greta%3BMullen%2C+Gregory%3BMartin%2C+Laura%3BMiller%2C+Louis%3BPierce%2C+Susan%3BCrompton%2C+Peter&rft.aulast=Mircetic&rft.aufirst=Marko&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Searching for Molecular Determinants of Species Specificity in Sand Flies Colonized by Leishmania Parasites T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41838084; 5079906 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Jochim, Ryan AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Sand KW - Specificity KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41838084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Searching+for+Molecular+Determinants+of+Species+Specificity+in+Sand+Flies+Colonized+by+Leishmania+Parasites&rft.au=Jochim%2C+Ryan%3BValenzuela%2C+Jesus&rft.aulast=Jochim&rft.aufirst=Ryan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase 1 Safety and Immunogenicity Trial of a Blood -Stage Malaria Vaccine AMA1-C1/ISA 720 in Australian Adults T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41836562; 5080097 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Arden Pierce, Mark AU - Ellis, Ruth AU - Malkin, Elissa AU - Miura, Kazutoyo AU - Marjason, Joanne AU - Mullen, Gregory AU - Long, Carole AU - Miller, Louis AU - Martin, Laura Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Australia KW - Vaccines KW - Immunogenicity KW - Malaria KW - Blood KW - Fish diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41836562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Phase+1+Safety+and+Immunogenicity+Trial+of+a+Blood+-Stage+Malaria+Vaccine+AMA1-C1%2FISA+720+in+Australian+Adults&rft.au=Arden+Pierce%2C+Mark%3BEllis%2C+Ruth%3BMalkin%2C+Elissa%3BMiura%2C+Kazutoyo%3BMarjason%2C+Joanne%3BMullen%2C+Gregory%3BLong%2C+Carole%3BMiller%2C+Louis%3BMartin%2C+Laura&rft.aulast=Arden+Pierce&rft.aufirst=Mark&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intranasal Administration of a Salmonella -Based Vaccine Expressing cp15 Antigen Confers Protection in Neonatal Mice Challenged with Cryptosporidium Parvum T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41836188; 5079061 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Cabal, Ace AU - Manque, Patricio AU - Lara, Ana AU - Woehlbier, Ute AU - Roche, James AU - Sevilleja, Jesus AU - Rivers-Davis, Andrea AU - Buck, Gregory AU - Guerrant, Richard Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Mice KW - Neonates KW - Intranasal administration KW - Anadromous species KW - Antigens KW - Disease control KW - Salmonella KW - Cryptosporidium parvum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41836188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Intranasal+Administration+of+a+Salmonella+-Based+Vaccine+Expressing+cp15+Antigen+Confers+Protection+in+Neonatal+Mice+Challenged+with+Cryptosporidium+Parvum&rft.au=Cabal%2C+Ace%3BManque%2C+Patricio%3BLara%2C+Ana%3BWoehlbier%2C+Ute%3BRoche%2C+James%3BSevilleja%2C+Jesus%3BRivers-Davis%2C+Andrea%3BBuck%2C+Gregory%3BGuerrant%2C+Richard&rft.aulast=Cabal&rft.aufirst=Ace&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The biochemical and biophysical characterization of an Escherichia coli expressed Plasmodium falciparum circumsporozoite protein (CSP), a leading malaria vaccine candidate T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41835672; 5078726 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Plassmeyer, Matthew AU - MacDonald, Nick AU - Reiter, Karine AU - Shimp, Richard AU - Zhang, Yanling AU - House, Brent AU - Lebowitz, Jack AU - Kotova, Svetlana AU - Jin, Albert AU - Hickman, Merrit AU - Herrera, Raul AU - Uchime, Onyinyechukwu AU - Nguyen, Vu AU - Glen, Jacqueline AU - Miller, Louis AU - Wu, Yimin AU - Narum, David Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Biochemistry KW - Circumsporozoite protein KW - Parasites KW - Public health KW - Disease control KW - Escherichia coli KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41835672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+biochemical+and+biophysical+characterization+of+an+Escherichia+coli+expressed+Plasmodium+falciparum+circumsporozoite+protein+%28CSP%29%2C+a+leading+malaria+vaccine+candidate&rft.au=Plassmeyer%2C+Matthew%3BMacDonald%2C+Nick%3BReiter%2C+Karine%3BShimp%2C+Richard%3BZhang%2C+Yanling%3BHouse%2C+Brent%3BLebowitz%2C+Jack%3BKotova%2C+Svetlana%3BJin%2C+Albert%3BHickman%2C+Merrit%3BHerrera%2C+Raul%3BUchime%2C+Onyinyechukwu%3BNguyen%2C+Vu%3BGlen%2C+Jacqueline%3BMiller%2C+Louis%3BWu%2C+Yimin%3BNarum%2C+David&rft.aulast=Plassmeyer&rft.aufirst=Matthew&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The relationship between malaria transmission intensity , clinical disease and mortality in an area of declining transmission T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834818; 5079851 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - O'Meara, Wendy AU - Mwangi, Tabitha AU - Williams, Thomas AU - McKenzie, F AU - Snow, Robert AU - Marsh, Kevin Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Disease transmission KW - Mortality KW - Malaria KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+relationship+between+malaria+transmission+intensity+%2C+clinical+disease+and+mortality+in+an+area+of+declining+transmission&rft.au=O%27Meara%2C+Wendy%3BMwangi%2C+Tabitha%3BWilliams%2C+Thomas%3BMcKenzie%2C+F%3BSnow%2C+Robert%3BMarsh%2C+Kevin&rft.aulast=O%27Meara&rft.aufirst=Wendy&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Production , characterization and immunological evaluation of an Escherichia coli expressed Plasmodium falciparum thrombospondin related apical merozoite protein (PTRAMP), a putative malaria vaccine candidate T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834541; 5080096 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Uchime, Onyinyechukwu AU - Reiter, Karine AU - Nguyen, Vu AU - Glen, Jacqueline AU - Miller, Louis AU - Narum, David AU - Plassmeyer, Matthew Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Vaccines KW - Malaria KW - Thrombospondin KW - Merozoites KW - Parasites KW - Public health KW - Disease control KW - Escherichia coli KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Production+%2C+characterization+and+immunological+evaluation+of+an+Escherichia+coli+expressed+Plasmodium+falciparum+thrombospondin+related+apical+merozoite+protein+%28PTRAMP%29%2C+a+putative+malaria+vaccine+candidate&rft.au=Uchime%2C+Onyinyechukwu%3BReiter%2C+Karine%3BNguyen%2C+Vu%3BGlen%2C+Jacqueline%3BMiller%2C+Louis%3BNarum%2C+David%3BPlassmeyer%2C+Matthew&rft.aulast=Uchime&rft.aufirst=Onyinyechukwu&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early Innate Immune Events in the Skin after Transmission of Yersinia Pestis by Fleas T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834471; 5079747 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Bosio, Christopher AU - Jarrett, Clayton AU - Hinnebusch, B Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Skin KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Early+Innate+Immune+Events+in+the+Skin+after+Transmission+of+Yersinia+Pestis+by+Fleas&rft.au=Bosio%2C+Christopher%3BJarrett%2C+Clayton%3BHinnebusch%2C+B&rft.aulast=Bosio&rft.aufirst=Christopher&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tyrosine Nitration of Proteins by a Putative Nitrate Reductase in Sexual and Asexual P. Falciparum Parasites T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41834175; 5079999 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ostera, Graciela AU - Ribeiro, Jose AU - Hume, Jennifer AU - Tokumasu, Fuyuki Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Parasites KW - Nitrate reductase KW - Nitration KW - Tyrosine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Tyrosine+Nitration+of+Proteins+by+a+Putative+Nitrate+Reductase+in+Sexual+and+Asexual+P.+Falciparum+Parasites&rft.au=Ostera%2C+Graciela%3BRibeiro%2C+Jose%3BHume%2C+Jennifer%3BTokumasu%2C+Fuyuki&rft.aulast=Ostera&rft.aufirst=Graciela&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A longitudinal study of the acquisition and maintenance of Plasmodium falciparum-specific memory B cells T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41833621; 5079106 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Weiss, Greta AU - Traore, Boubacar AU - Doumbo, Safiatou AU - Doumtabe, Didier AU - Kone, Younoussou AU - Mircetic, Marko AU - Ongoiba, Aissata AU - Kayentao, Kassoum AU - Doumbo, Ogobara AU - Pierce, Susan AU - Crompton, Peter Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Longitudinal studies KW - Lymphocytes B KW - Memory cells KW - Immunological memory KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41833621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=A+longitudinal+study+of+the+acquisition+and+maintenance+of+Plasmodium+falciparum-specific+memory+B+cells&rft.au=Weiss%2C+Greta%3BTraore%2C+Boubacar%3BDoumbo%2C+Safiatou%3BDoumtabe%2C+Didier%3BKone%2C+Younoussou%3BMircetic%2C+Marko%3BOngoiba%2C+Aissata%3BKayentao%2C+Kassoum%3BDoumbo%2C+Ogobara%3BPierce%2C+Susan%3BCrompton%2C+Peter&rft.aulast=Weiss&rft.aufirst=Greta&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression between Infective and Non -Infective Stage Strongyloides Stercoralis Larvae Revealed by Microarray T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41833595; 5080244 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ramanathan, Roshan AU - Abraham, David AU - Myers, Timothy AU - Nutman, Thomas Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Larvae KW - Gene expression KW - Strongyloides stercoralis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41833595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Differential+Gene+Expression+between+Infective+and+Non+-Infective+Stage+Strongyloides+Stercoralis+Larvae+Revealed+by+Microarray&rft.au=Ramanathan%2C+Roshan%3BAbraham%2C+David%3BMyers%2C+Timothy%3BNutman%2C+Thomas&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Diagnostics and Speciation Guide Choice of Alternative , Short-Course Treatment Regimens for Cutaneous Leishmaniasis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41829358; 5079334 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Ramanathan, Roshan AU - Talaat, Kawsar AU - Fedorko, Daniel AU - Mahanty, Siddhartha AU - Nash, Theodore Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Speciation KW - Cutaneous leishmaniasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Molecular+Diagnostics+and+Speciation+Guide+Choice+of+Alternative+%2C+Short-Course+Treatment+Regimens+for+Cutaneous+Leishmaniasis&rft.au=Ramanathan%2C+Roshan%3BTalaat%2C+Kawsar%3BFedorko%2C+Daniel%3BMahanty%2C+Siddhartha%3BNash%2C+Theodore&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Navigating the Nationalational Institutes of Health system T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41829300; 5078816 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Costero, Adriana Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Navigating+the+Nationalational+Institutes+of+Health+system&rft.au=Costero%2C+Adriana&rft.aulast=Costero&rft.aufirst=Adriana&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Stoichiometry of Antibody -Mediated Neutralization of West Nile Virus Infection : Factors That Govern Antibody Potency T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41827012; 5079352 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Nelson, Steevenson AU - Mehlhop, Erin AU - Jost, Christiane AU - Johnson, Syd AU - Fremont, Daved AU - Diamond, Michael AU - Pierson, Theodore Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Infection KW - Neutralization KW - Antibodies KW - West Nile virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41827012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=The+Stoichiometry+of+Antibody+-Mediated+Neutralization+of+West+Nile+Virus+Infection+%3A+Factors+That+Govern+Antibody+Potency&rft.au=Nelson%2C+Steevenson%3BMehlhop%2C+Erin%3BJost%2C+Christiane%3BJohnson%2C+Syd%3BFremont%2C+Daved%3BDiamond%2C+Michael%3BPierson%2C+Theodore&rft.aulast=Nelson&rft.aufirst=Steevenson&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How to Turn Potentiation to Protection : Impact of Immunity to Sand Fly Saliva on Leishmaniasis T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41821928; 5080176 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Valenzuela, Jesus Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Sand KW - Leishmaniasis KW - Immunity KW - Saliva KW - Potentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41821928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=How+to+Turn+Potentiation+to+Protection+%3A+Impact+of+Immunity+to+Sand+Fly+Saliva+on+Leishmaniasis&rft.au=Valenzuela%2C+Jesus&rft.aulast=Valenzuela&rft.aufirst=Jesus&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patent filarial infection modulates malaria -specific Type 1 cytokine responses in an IL-10 dependent manner in a filaria /malaria co -infected population T2 - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AN - 41820354; 5080392 JF - 57th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2008) AU - Metenou, Simon AU - Dembele, Benoit AU - Konate, Siaka AU - Dolo, Housseini AU - Soumaoro, Lamine AU - Diallo, Abdallah AU - Coulibaly, Michel AU - Coulibaly, Siaka AU - Sanogo, Dramane AU - Coulibaly, Yaya AU - Traore, Sekou AU - Klion, Amy AU - Nutman, Thomas AU - Mahanty, Siddhartha Y1 - 2008/12/07/ PY - 2008 DA - 2008 Dec 07 KW - Malaria KW - Infection KW - Patents KW - Interleukin 10 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41820354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.atitle=Patent+filarial+infection+modulates+malaria+-specific+Type+1+cytokine+responses+in+an+IL-10+dependent+manner+in+a+filaria+%2Fmalaria+co+-infected+population&rft.au=Metenou%2C+Simon%3BDembele%2C+Benoit%3BKonate%2C+Siaka%3BDolo%2C+Housseini%3BSoumaoro%2C+Lamine%3BDiallo%2C+Abdallah%3BCoulibaly%2C+Michel%3BCoulibaly%2C+Siaka%3BSanogo%2C+Dramane%3BCoulibaly%2C+Yaya%3BTraore%2C+Sekou%3BKlion%2C+Amy%3BNutman%2C+Thomas%3BMahanty%2C+Siddhartha&rft.aulast=Metenou&rft.aufirst=Simon&rft.date=2008-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=57th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/documents/ASTMH08FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of Age-Related Changes in Bone Marrow T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41980810; 5123272 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Longo, Dan Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Bone marrow KW - Reviews KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41980810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Overview+of+Age-Related+Changes+in+Bone+Marrow&rft.au=Longo%2C+Dan&rft.aulast=Longo&rft.aufirst=Dan&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of Acute Lymphoblastic Leukemia in Children and Adolescents: Peaks and Pitfalls T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41980532; 5123215 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Seibel, Nita Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Adolescents KW - Acute lymphatic leukemia KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41980532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Treatment+of+Acute+Lymphoblastic+Leukemia+in+Children+and+Adolescents%3A+Peaks+and+Pitfalls&rft.au=Seibel%2C+Nita&rft.aulast=Seibel&rft.aufirst=Nita&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hemolytic-Anemia-Associated Pulmonary Hypertension and Endothelial Dysfunction: An Emerging Cause of Mortality in Hemolytic Disease T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41965195; 5123131 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Gladwin, Mark Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Hypertension KW - Mortality KW - Hemolytic disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41965195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Hemolytic-Anemia-Associated+Pulmonary+Hypertension+and+Endothelial+Dysfunction%3A+An+Emerging+Cause+of+Mortality+in+Hemolytic+Disease&rft.au=Gladwin%2C+Mark&rft.aulast=Gladwin&rft.aufirst=Mark&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mild Pro-Inflammatory State and Anemia in Older Persons T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41964691; 5123275 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Ferrucci, Luigi Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Anemia KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41964691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Mild+Pro-Inflammatory+State+and+Anemia+in+Older+Persons&rft.au=Ferrucci%2C+Luigi&rft.aulast=Ferrucci&rft.aufirst=Luigi&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Lymphoblastic Leukemia in Children and Adolescents T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41928985; 5123140 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Seibel, Nita Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Adolescents KW - Acute lymphatic leukemia KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41928985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Acute+Lymphoblastic+Leukemia+in+Children+and+Adolescents&rft.au=Seibel%2C+Nita&rft.aulast=Seibel&rft.aufirst=Nita&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Small-Molecule Therapeutics for Sickle Cell Disease: Nitric Oxide, Carbon Monoxide, Nitrite, and Apolipoprotein A T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41922479; 5123197 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Kato, Gregory Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Carbon monoxide KW - Nitrite KW - Nitric oxide KW - Apolipoprotein A KW - Sickle cell disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41922479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Novel+Small-Molecule+Therapeutics+for+Sickle+Cell+Disease%3A+Nitric+Oxide%2C+Carbon+Monoxide%2C+Nitrite%2C+and+Apolipoprotein+A&rft.au=Kato%2C+Gregory&rft.aulast=Kato&rft.aufirst=Gregory&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biology Lessons From Human Disease--the Pathophysiology of Bone Marrow Failure T2 - 50th Annual Meeting and Exposition of the American Society of Hematology AN - 41902609; 5123114 JF - 50th Annual Meeting and Exposition of the American Society of Hematology AU - Young, Neal Y1 - 2008/12/06/ PY - 2008 DA - 2008 Dec 06 KW - Bone marrow KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41902609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.atitle=Biology+Lessons+From+Human+Disease--the+Pathophysiology+of+Bone+Marrow+Failure&rft.au=Young%2C+Neal&rft.aulast=Young&rft.aufirst=Neal&rft.date=2008-12-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Annual+Meeting+and+Exposition+of+the+American+Society+of+Hematology&rft.issn=&rft_id=info:doi/ L2 - http://www.hematology.org/meetings/2008/program/index.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insights on the "Oaks" of the Forest of Life T2 - 6th Annual Rocky Mountain Bioinformatics Conference (ROCKY 2008) AN - 41693291; 4999581 JF - 6th Annual Rocky Mountain Bioinformatics Conference (ROCKY 2008) AU - Puigbo, Pere Y1 - 2008/12/04/ PY - 2008 DA - 2008 Dec 04 KW - Forests KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41693291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28ROCKY+2008%29&rft.atitle=Insights+on+the+%22Oaks%22+of+the+Forest+of+Life&rft.au=Puigbo%2C+Pere&rft.aulast=Puigbo&rft.aufirst=Pere&rft.date=2008-12-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28ROCKY+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/cms_addon/conferences/rocky08/pdf/ProgramBookRocky 08.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Obesity, Mammography Use and Accuracy, and Advanced Breast Cancer Risk AN - 20457905; 9145974 AB - Background Being overweight or obese is associated with increased breast cancer risk and disease severity among postmenopausal women, but whether extent of mammography use and accuracy modify this association and further contribute to increases in disease severity at diagnosis among overweight and obese women is unclear.Methods We prospectively collected data during 1996-2005 on 287115 postmenopausal women not using hormone therapy (HT) who underwent 614562 mammography examinations; 4446 women were diagnosed with breast cancer within 12 months of a mammography examination. We calculated rates per 1000 mammography examinations of large (>15 mm), advanced-stage (IIb, III, or IV), high-grade (3 or 4), estrogen receptor (ER)-positive and -negative, and screen-detected and non-screen-detected breast cancer across body mass index (BMI, kg/m2 ) groups defined as normal (18.5-24.9), overweight (25.0-29.9), obese class I (30.0-34.9), and obese class II/III ( greater than or equal to 35.0), adjusting for age, race/ethnicity, and mammography registry and use. All statistical tests were two-sided.Results Adjusted rates per 1000 mammography examinations of overall breast cancer increased across BMI groups (6.6 normal, 7.4 overweight, 7.9 obese I, 8.5 obese II/III; Ptrend < .001), as did rates of advanced disease, including large invasive (2.3 normal, 2.6 overweight, 2.9 obese I, 3.2 obese II/III; Ptrend < .001), advanced-stage (0.8 normal, 0.9 overweight, 1.3 obese I, 1.5 obese II/III; Ptrend < .001), and high nuclear grade (1.5 normal, 1.7 overweight, 1.7 obese I, 1.9 obese II/III; Ptrend = .10) tumors. Rates of ER-positive tumors increased across BMI groups (Ptrend < .001); rates of ER-negative tumors did not. Rates of screen-detected cancers were higher among overweight and obese women than normal and underweight women, but rates of non-screen-detected (false-negative) cancers were similar. Rates of advanced breast cancer increased across BMI groups regardless of extent of mammography use.Conclusions Patterns of mammography use and mammography accuracy are not the primary reasons for higher rates of advanced breast cancer among overweight and obese postmenopausal women not using HT; thus, biologic differences in breast tumor development and/or progression may be important. JF - Journal of the National Cancer Institute AU - Kerlikowske, Karla AU - Walker, Rod AU - Miglioretti, Diana L AU - Desai, Arati AU - Ballard-Barbash, Rachel AU - Buist, Diana SM AD - Affiliations of authors: Departments of Epidemiology and Biostatistics (KK) and General Internal Medicine Section, Department of Veterans Affairs, University of California, San Francisco, CA (KK); Group Health Center for Health Studies, Seattle, WA (RW, DLM, DSMB); Department of Biostatistics, University of Washington, Seattle, WA (DLM); Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD (AD); Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD (RBB), karla.kerlikowske@ucsf.edu Y1 - 2008/12/03/ PY - 2008 DA - 2008 Dec 03 SP - 1724 EP - 1733 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 23 SN - 0027-8874, 0027-8874 KW - Physical Education Index; Risk Abstracts KW - Obesity KW - Age KW - Mammography KW - post-menopause KW - Body mass KW - Women KW - obesity KW - tumors KW - Breasts KW - Tumors KW - Hormones KW - Cancer KW - Evaluation KW - body mass KW - Breast cancer KW - Diseases KW - Ethnic groups KW - estrogens KW - PE 090:Sports Medicine & Exercise Sport Science KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20457905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Obesity%2C+Mammography+Use+and+Accuracy%2C+and+Advanced+Breast+Cancer+Risk&rft.au=Kerlikowske%2C+Karla%3BWalker%2C+Rod%3BMiglioretti%2C+Diana+L%3BDesai%2C+Arati%3BBallard-Barbash%2C+Rachel%3BBuist%2C+Diana+SM&rft.aulast=Kerlikowske&rft.aufirst=Karla&rft.date=2008-12-03&rft.volume=100&rft.issue=23&rft.spage=1724&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn388 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Mammography; Body mass; Women; Breasts; Diseases; Tumors; Cancer; Age; post-menopause; body mass; obesity; Breast cancer; tumors; Hormones; Ethnic groups; estrogens DO - http://dx.doi.org/10.1093/jnci/djn388 ER - TY - JOUR T1 - Fat, Protein, and Meat Consumption and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies AN - 20456720; 9145971 AB - Background Results of several case-control studies suggest that high consumption of meat (all meat, red meat, or processed meat) is associated with an increased risk of renal cell cancer, but only a few prospective studies have examined the associations of intakes of meat, fat, and protein with renal cell cancer.Methods We conducted a pooled analysis of 13 prospective studies that included 530469 women and 244483 men and had follow-up times of up to 7-20 years to examine associations between meat, fat, and protein intakes and the risk of renal cell cancer. All participants had completed a validated food frequency questionnaire at study entry. Using the primary data from each study, we calculated the study-specific relative risks (RRs) for renal cell cancer by using Cox proportional hazards models and then pooled these RRs by using a random-effects model. All statistical tests were two-sided.Results A total of 1478 incident cases of renal cell cancer were identified (709 in women and 769 in men). We observed statistically significant positive associations or trends in pooled age-adjusted models for intakes of total fat, saturated fat, monounsaturated fat, polyunsaturated fat, cholesterol, total protein, and animal protein. However, these associations were attenuated and no longer statistically significant after adjusting for body mass index, fruit and vegetable intake, and alcohol intake. For example, the pooled age-adjusted RR of renal cell cancer for the highest vs the lowest quintile of intake for total fat was 1.30 (95% confidence interval [CI] = 1.08 to 1.56; Ptrend = .001) and for total protein was 1.17 (95% CI = 0.99 to 1.38; Ptrend = .02). By comparison, the pooled multivariable RR for the highest vs the lowest quintile of total fat intake was 1.10 (95% CI = 0.92 to 1.32; Ptrend = .31) and of total protein intake was 1.06 (95% CI = 0.89 to 1.26; Ptrend = .37). Intakes of red meat, processed meat, poultry, or seafood were not associated with the risk of renal cell cancer.Conclusions Intakes of fat and protein or their subtypes, red meat, processed meat, poultry, and seafood are not associated with risk of renal cell cancer. JF - Journal of the National Cancer Institute AU - Lee, Jung Eun AU - Spiegelman, Donna AU - Hunter, David J AU - Albanes, Demetrius AU - Bernstein, Leslie AU - van den Brandt, Piet A AU - Buring, Julie E AU - Cho, Eunyoung AU - English, Dallas R AU - Freudenheim, Jo L AU - Giles, Graham G AU - Graham, Saxon AU - Horn-Ross, Pamela L AU - Haakansson, Niclas AU - Leitzmann, Michael F AU - Maennistoe, Satu AU - McCullough, Marjorie L AU - Miller, Anthony B AU - Parker, Alexander S AU - Rohan, Thomas E AU - Schatzkin, Arthur AU - Schouten, Leo J AU - Sweeney, Carol AU - Willett, Walter C AU - Wolk, Alicja AU - Zhang, Shumin M AU - Smith-Warner, Stephanie A AD - Affiliations of authors: Channing Laboratory (JEL, DJH, EC, WCW) and Division of Preventive Medicine (JEB, SMZ), Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA; Department of Epidemiology (DS, DJH, JEB, WCW, SASW), Department of Nutrition (DJH, WCW, SASW), and Department of Biostatistics (DS), Harvard School of Public Health, Boston, MA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Health Services, Bethesda, MD (DA, MFL, AS); City of Hope Comprehensive Cancer Center and Beckman Research Institute, City of Hope National Medical Center, Duarte, CA (LB); Department of Epidemiology, GROW-School for Oncology and Developmental Biology, University Maastricht, Maastricht, The Netherlands (PAvdB, LJS); Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Australia (DRE, GGG); Department of Social and Preventive Medicine, University at Buffalo, State U, jung.lee@channing.harvard.edu Y1 - 2008/12/03/ PY - 2008 DA - 2008 Dec 03 SP - 1695 EP - 1706 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 23 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Alcohol KW - poultry KW - body mass KW - fruits KW - Proteins KW - Seafood KW - cholesterol KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20456720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Fat%2C+Protein%2C+and+Meat+Consumption+and+Renal+Cell+Cancer+Risk%3A+A+Pooled+Analysis+of+13+Prospective+Studies&rft.au=Lee%2C+Jung+Eun%3BSpiegelman%2C+Donna%3BHunter%2C+David+J%3BAlbanes%2C+Demetrius%3BBernstein%2C+Leslie%3Bvan+den+Brandt%2C+Piet+A%3BBuring%2C+Julie+E%3BCho%2C+Eunyoung%3BEnglish%2C+Dallas+R%3BFreudenheim%2C+Jo+L%3BGiles%2C+Graham+G%3BGraham%2C+Saxon%3BHorn-Ross%2C+Pamela+L%3BHaakansson%2C+Niclas%3BLeitzmann%2C+Michael+F%3BMaennistoe%2C+Satu%3BMcCullough%2C+Marjorie+L%3BMiller%2C+Anthony+B%3BParker%2C+Alexander+S%3BRohan%2C+Thomas+E%3BSchatzkin%2C+Arthur%3BSchouten%2C+Leo+J%3BSweeney%2C+Carol%3BWillett%2C+Walter+C%3BWolk%2C+Alicja%3BZhang%2C+Shumin+M%3BSmith-Warner%2C+Stephanie+A&rft.aulast=Lee&rft.aufirst=Jung&rft.date=2008-12-03&rft.volume=100&rft.issue=23&rft.spage=1695&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn386 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Alcohol; poultry; body mass; fruits; Proteins; Seafood; cholesterol; Cancer DO - http://dx.doi.org/10.1093/jnci/djn386 ER - TY - JOUR T1 - Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users. AN - 69827185; 19034286 AB - Domestic fuel combustion from cooking and heating, to which about 3 billion people worldwide are exposed, is associated with increased lung cancer risk. Lung cancer incidence in Xuanwei is the highest in China, and the attributable risk of lung cancer from unvented smoky coal burning is greater than 90%. To evaluate any lung cancer mortality reduction after changing from unvented stoves to portable stoves, we used lifetime smoky coal users in a retrospective cohort of all farmers born during 1917-1951 and residing in Xuanwei in 1976. Of the 42,422 enrolled farmers, 4054 lifetime smoky coal users changed to portable stoves, 4364 did not change, and 1074 died of lung cancer. Lung cancer morality associated with stove change was assessed by product-limit survival curves and multivariate Cox regression models. Both men (P<0.0001) and women (P<0.0001) who changed to portable stoves had a significantly increased probability of survival compared with those who did not change. Portable stoves were associated with decreased risk of lung cancer mortality in male participants (hazard ratio (HR)=0.62, 95% confidence interval (CI)=0.46-0.82) and female participants (HR=0.41, 95% CI=0.29-0.57). Portable stove use is associated with reduced lung cancer mortality risk, highlighting a cost-effective intervention that could substantially benefit health in developing countries. JF - British journal of cancer AU - Hosgood, H D AU - Chapman, R AU - Shen, M AU - Blair, A AU - Chen, E AU - Zheng, T AU - Lee, K-M AU - He, X AU - Lan, Q AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7240, USA. hosgoodd@mail.nih.gov Y1 - 2008/12/02/ PY - 2008 DA - 2008 Dec 02 SP - 1934 EP - 1939 VL - 99 IS - 11 KW - Coal KW - 0 KW - Smoke KW - Index Medicus KW - Ventilation KW - Humans KW - China -- epidemiology KW - Surveys and Questionnaires KW - Retrospective Studies KW - Male KW - Female KW - Proportional Hazards Models KW - Smoke -- adverse effects KW - Air Pollution, Indoor -- adverse effects KW - Lung Neoplasms -- etiology KW - Coal -- adverse effects KW - Cooking -- methods KW - Lung Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69827185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Portable+stove+use+is+associated+with+lower+lung+cancer+mortality+risk+in+lifetime+smoky+coal+users.&rft.au=Hosgood%2C+H+D%3BChapman%2C+R%3BShen%2C+M%3BBlair%2C+A%3BChen%2C+E%3BZheng%2C+T%3BLee%2C+K-M%3BHe%2C+X%3BLan%2C+Q&rft.aulast=Hosgood&rft.aufirst=H&rft.date=2008-12-02&rft.volume=99&rft.issue=11&rft.spage=1934&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fsj.bjc.6604744 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-30 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Indoor Air. 2000 Sep;10(3):200-5 [10979201] Am J Epidemiol. 2007 Jun 1;165(11):1280-6 [17369610] Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Jun;23(3):186-9 [12411086] Toxicology. 2004 May 20;198(1-3):301-5 [15138056] Health Educ Res. 2004 Oct;19(5):543-50 [15199008] Science. 1987 Jan 9;235(4785):217-20 [3798109] Arch Environ Health. 1988 Mar-Apr;43(2):180-5 [3377554] J Natl Cancer Inst. 1989 Dec 6;81(23):1800-6 [2555531] IARC Sci Publ. 1991;(105):460-5 [1855896] Carcinogenesis. 1995 Dec;16(12):3031-6 [8603481] CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 [15761078] Br J Cancer. 2005 Oct 3;93(7):825-33 [16160696] BMJ. 2005 Nov 5;331(7524):1050 [16234255] Soc Sci Med. 2006 Jun;62(12):3161-76 [16426715] Int J Hyg Environ Health. 2006 Sep;209(5):445-50 [16765087] J Epidemiol Community Health. 2007 Jan;61(1):74-9 [17183019] Lancet Oncol. 2006 Dec;7(12):977-8 [17348122] J Natl Cancer Inst. 2002 Jun 5;94(11):826-35 [12048270] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.bjc.6604744 ER - TY - JOUR T1 - Breast cancer incidence following low-dose rate environmental exposure: Techa River Cohort, 1956-2004. AN - 69824240; 19002173 AB - In the 1950s, the Mayak nuclear weapons facility in Russia discharged liquid radioactive wastes into the Techa River causing exposure of riverside residents to protracted low-to-moderate doses of radiation. Almost 10,000 women received estimated doses to the stomach of up to 0.47 Gray (Gy) (mean dose=0.04 Gy) from external gamma-exposure and (137)Cs incorporation. We have been following this population for cancer incidence and mortality and as in the general Russian population, we found a significant temporal trend of breast cancer incidence. A significant linear radiation dose-response relationship was observed (P=0.01) with an estimated excess relative risk per Gray (ERR/Gy) of 5.00 (95% confidence interval (CI), 0.80, 12.76). We estimated that approximately 12% of the 109 observed cases could be attributed to radiation. JF - British journal of cancer AU - Ostroumova, E AU - Preston, D L AU - Ron, E AU - Krestinina, L AU - Davis, F G AU - Kossenko, M AU - Akleyev, A AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, MS 7238, 6120 Executive Boulevard, Bethesda, MD 20892-7238, USA. zhenia@urcrm.chel.su Y1 - 2008/12/02/ PY - 2008 DA - 2008 Dec 02 SP - 1940 EP - 1945 VL - 99 IS - 11 KW - Index Medicus KW - Humans KW - Incidence KW - Russia KW - Dose-Response Relationship, Radiation KW - Female KW - Neoplasms, Radiation-Induced -- etiology KW - Radioactive Hazard Release KW - Neoplasms, Radiation-Induced -- epidemiology KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69824240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Breast+cancer+incidence+following+low-dose+rate+environmental+exposure%3A+Techa+River+Cohort%2C+1956-2004.&rft.au=Ostroumova%2C+E%3BPreston%2C+D+L%3BRon%2C+E%3BKrestinina%2C+L%3BDavis%2C+F+G%3BKossenko%2C+M%3BAkleyev%2C+A&rft.aulast=Ostroumova&rft.aufirst=E&rft.date=2008-12-02&rft.volume=99&rft.issue=11&rft.spage=1940&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fsj.bjc.6604775 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-30 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1984 Jul 15;34(1):71-5 [6746122] Vopr Onkol. 1982;28(10):26-71 [7147820] Int J Epidemiol. 1989 Sep;18(3):498-510 [2807650] Radiat Res. 1991 Feb;125(2):214-22 [1996380] Cancer Causes Control. 1990 Jul;1(1):39-49 [2102275] Vopr Onkol. 1991;37(4):401-36 [1887640] J Natl Cancer Inst. 1993 Oct 20;85(20):1679-85 [8411245] Vopr Onkol. 1992;38(12):1413-83 [1343179] Sci Total Environ. 1994 Mar 1;142(1-2):1-8 [8178126] Sci Total Environ. 1994 Mar 1;142(1-2):49-61 [8178136] Radiat Res. 1999 May;151(5):626-32 [10319736] Radiat Res. 2005 Oct;164(4 Pt 1):409-19 [16187743] Radiat Res. 2005 Nov;164(5):591-601 [16238436] Radiat Res. 2005 Nov;164(5):602-11 [16238437] Int J Cancer. 2006 Aug 1;119(3):651-8 [16506213] J Travel Med. 2006 May-Jun;13(3):127-32 [16706942] Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Radiat Res. 2006 Jul;166(1 Pt 2):255-70 [16808612] Radiat Res. 2007 Jul;168(1):1-64 [17722996] Int J Epidemiol. 2007 Oct;36(5):1038-46 [17768163] Health Phys. 2000 May;78(5):542-54 [10772028] Health Phys. 2000 Jul;79(1):24-35 [10855775] Spine (Phila Pa 1976). 2000 Aug 15;25(16):2052-63 [10954636] Cancer Causes Control. 2001 Feb;12(2):95-101 [11246849] Health Phys. 2002 Apr;82(4):455-66 [11906134] Radiat Res. 2002 Aug;158(2):220-35 [12105993] Radiat Environ Biophys. 2003 Oct;42(3):169-74 [14579133] Radiat Res. 2003 Dec;160(6):707-17 [14640793] Vopr Onkol. 1975;21(1):3-16 [163550] N Engl J Med. 1989 Nov 9;321(19):1281-4 [2797100] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/sj.bjc.6604775 ER - TY - JOUR T1 - Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry AN - 883023686; 15305944 AB - The HIV-1 co-receptor CCR5 possesses sulfo-tyrosine (TYS) residues at its N-terminus (Nt) that are required for binding HIV-1 gp120 and mediating viral entry. By using a 14-residue fragment of CCR5 Nt containing two TYS residues, we recently showed that CCR5 Nt binds gp120 through a conserved region specific for TYS moieties and suggested that this site may represent a target for inhibitors and probes of HIV-1 entry. As peptides containing sulfo-tyrosines are difficult to synthesize and handle due to limited stability of the sulfo-ester moiety, we have now incorporated TYS isosteres into CCR5 Nt analogs and assessed their binding to a complex of gp120-CD4 using saturation transfer difference (STD) NMR and surface plasmon resonance (SPR). STD enhancements for CCR5 Nt peptides containing tyrosine sulfonate (TYSN) in complex with gp120-CD4 were very similar to those observed for sulfated CCR5 Nt peptides indicating comparable modes of binding. STD enhancements for phosphotyrosine-containing CCR5 Nt analogs were greatly diminished consistent with earlier findings showing sulfo-tyrosine to be essential for CCR5 Nt binding to gp120. Tyrosine sulfonate-containing CCR5 peptides exhibited reduced water solubility, limiting their use in assay and probe development. To improve solubility, we designed, synthesized, and incorporated in CCR5 Nt peptide analogs an orthogonally functionalized azido tris(ethylenoxy) l-alanine (l-ate-Ala) residue. Through NMR and SPR experiments, we show a 19-residue TYSN-containing peptide to be a functional, hydrolytically stable CCR5 Nt isostere that was in turn used to develop both SPR-based and ELISA assays to screen for inhibitors of CCR5 binding to gp120-CD4. JF - Bioorganic and Medicinal Chemistry AU - Lam, Son N AU - Acharya, Priyamvada AU - Wyatt, Richard AU - Kwong, Peter D AU - Bewley, Carole A Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 10113 EP - 10120 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 16 IS - 23 SN - 0968-0896, 0968-0896 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - CCR5 protein KW - Development KW - Enzyme-linked immunosorbent assay KW - Glycoprotein gp120 KW - L-Alanine KW - N-Terminus KW - N.M.R. KW - Probes KW - Solubility KW - Tyrosine KW - surface plasmon resonance KW - Human immunodeficiency virus 1 KW - V 22360:AIDS and HIV KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883023686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Tyrosine-sulfate+isosteres+of+CCR5+N-terminus+as+tools+for+studying+HIV-1+entry&rft.au=Lam%2C+Son+N%3BAcharya%2C+Priyamvada%3BWyatt%2C+Richard%3BKwong%2C+Peter+D%3BBewley%2C+Carole+A&rft.aulast=Lam&rft.aufirst=Son&rft.date=2008-12-01&rft.volume=16&rft.issue=23&rft.spage=10113&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-02-22 N1 - SubjectsTermNotLitGenreText - Glycoprotein gp120; Enzyme-linked immunosorbent assay; surface plasmon resonance; Solubility; L-Alanine; Probes; Tyrosine; N.M.R.; CCR5 protein; Development; N-Terminus; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bmc.2008.10.005 ER - TY - JOUR T1 - Literacy-Based Normative Data For Low Socioeconomic Status African Americans AN - 85692413; 200906967 AB - Clinical neuropsychology relies on the use of appropriate test norms. Normative studies frequently stratify based on age, education, sex, and race. None to date has reported norms based on literacy, despite the substantial evidence that literacy impacts cognitive functioning. Some researchers have suggested that literacy is a more accurate reflection of academic achievement and quality of education than years of education, particularly for African Americans. The current study provides literacy-based normative data for multiple neuropsychological measures based on a sample of predominantly low socioeconomic status African Americans. These normative data should improve the diagnostic accuracy of performances by African-American clients with similar demographic backgrounds. Adapted from the source document JF - The Clinical Neuropsychologist AU - Dotson, Vonetta M AU - Kitner-Triolo, Melissa AU - Evans, Michele K AU - Zonderman, Alan B AD - National Institute on Aging, Gerontology Research Center, 5600 Nathan Shock Dr., Baltimore, MD 21224, USA dotsonv@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 989 EP - 1017 VL - 22 IS - 6 SN - 1385-4046, 1385-4046 KW - Literacy (48550) KW - Diagnostic Tests (18550) KW - Black Americans (09100) KW - Socioeconomic Status (80150) KW - Academic Achievement (00070) KW - Test Validity and Reliability (88800) KW - Neuropsychological Assessment (57285) KW - article KW - 4115: applied linguistics; adult language development/literacy studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85692413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Clinical+Neuropsychologist&rft.atitle=Literacy-Based+Normative+Data+For+Low+Socioeconomic+Status+African+Americans&rft.au=Dotson%2C+Vonetta+M%3BKitner-Triolo%2C+Melissa%3BEvans%2C+Michele+K%3BZonderman%2C+Alan+B&rft.aulast=Dotson&rft.aufirst=Vonetta&rft.date=2008-12-01&rft.volume=22&rft.issue=6&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=The+Clinical+Neuropsychologist&rft.issn=13854046&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLNEEC N1 - SubjectsTermNotLitGenreText - Literacy (48550); Socioeconomic Status (80150); Test Validity and Reliability (88800); Black Americans (09100); Academic Achievement (00070); Neuropsychological Assessment (57285); Diagnostic Tests (18550) ER - TY - JOUR T1 - Introduction to the Special Section: Transformative Research on Emotion Regulation and Dysregulation AN - 839605670; 201100972 AB - Scholars are giving increased attention to the need to incorporate research on more basic developmental processes into new paradigms for understanding and treating mental illness in children and adolescents. The study of emotion regulation, rooted in neurodevelopment, has proven a fruitful model for understanding and characterizing problems of behavior and risk in children and adolescents. This article summarizes NIMH initiatives designed to encourage transformational research on the neurodevelopment origins of mental illness. It highlights the NIMH Strategic Plan and the Report on Transformative Neurodevelopment Research as part of an introduction to a collection of articles that grew out of a previously organized NIMH workshop on developmental and translational models of emotion regulation and dysregulation. Adapted from the source document. JF - Child Development Perspectives AU - Delcarmen-Wiggins, Rebecca Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 121 EP - 123 PB - Wiley Publishing, Malden, MA 02148 VL - 2 IS - 3 SN - 1750-8592, 1750-8592 KW - emotion regulation KW - neurodevelopment KW - translational models KW - transformational research KW - Workshops KW - Mental illness KW - Developmental processes KW - Emotional regulation KW - Children KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839605670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development+Perspectives&rft.atitle=Introduction+to+the+Special+Section%3A+Transformative+Research+on+Emotion+Regulation+and+Dysregulation&rft.au=Delcarmen-Wiggins%2C+Rebecca&rft.aulast=Delcarmen-Wiggins&rft.aufirst=Rebecca&rft.date=2008-12-01&rft.volume=2&rft.issue=3&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Child+Development+Perspectives&rft.issn=17508592&rft_id=info:doi/10.1111%2Fj.1750-8606.2008.00053.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Emotional regulation; Mental illness; Adolescents; Children; Workshops; Developmental processes DO - http://dx.doi.org/10.1111/j.1750-8606.2008.00053.x ER - TY - JOUR T1 - Altered b-Catenin Accumulation in Hepatocellular Carcinomas of Diethylnitrosamine-Exposed Rhesus Macaques AN - 746198376; 12621191 AB - Chemical exposures are important risks for development of hepatocellular carcinoma (HCC). One such chemical, diethylnitrosamine (DENA), is present in food products as well as in industrial and research settings. Further examination of tumors induced by DENA may yield clues to human risk. HCC from seven rhesus macaques exposed to DENA was selected from a tissue archive to examine for evidence of Wnt/b-catenin signaling events, which are frequently associated with HCC. DENA exposure durations ranged from 8 to 207 months, and total accumulated dose ranged from 0.7 to 4.08 mg. Unexposed colony breeder macaques served as controls. Previously unrecognized HCC metastases were discovered in lungs of three macaques. Overexpression of b-catenin and glutamine synthetase was detected by immunohistochemistry in six confirmed primary HCC and all metastatic HCC, which implicated Wnt/b-catenin activation. Concomitant b-catenin gene mutation was detected in one primary HCC; similar findings have been reported in human and rodent HCC. Neither b-catenin mutation nor b-catenin overexpression appeared to influence metastatic potential. Accumulation of intracellular proteins involved in Wnt/b-catenin signaling during HCC oncogenesis in rhesus macaques exposed to DENA appears to include other mechanisms, in addition to mutation of b-catenin gene. JF - Toxicologic Pathology AU - Wei, Bih-Rong AU - Edwards, Jennifer B AU - Hoover, Shelley B AU - Tillman, Heather S AU - Reed, LTiffany AU - Sills, Robert C AU - Simpson, RMark AD - Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA, ms43b@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 972 EP - 980 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 36 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - biological specimen banks KW - sequence analysis KW - DNA KW - carcinogens KW - mutagens KW - signal transduction pathway KW - Intracellular signalling KW - Wnt protein KW - Food KW - Point mutation KW - Tumorigenesis KW - Diethylnitrosamine KW - Tumors KW - Glutamate-ammonia ligase KW - Metastases KW - Colonies KW - catenin KW - Lung KW - Macaca mulatta KW - Immunohistochemistry KW - Signal transduction KW - Hepatocellular carcinoma KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746198376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Altered+b-Catenin+Accumulation+in+Hepatocellular+Carcinomas+of+Diethylnitrosamine-Exposed+Rhesus+Macaques&rft.au=Wei%2C+Bih-Rong%3BEdwards%2C+Jennifer+B%3BHoover%2C+Shelley+B%3BTillman%2C+Heather+S%3BReed%2C+LTiffany%3BSills%2C+Robert+C%3BSimpson%2C+RMark&rft.aulast=Wei&rft.aufirst=Bih-Rong&rft.date=2008-12-01&rft.volume=36&rft.issue=7&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623308327120 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 31 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Intracellular signalling; Wnt protein; Food; Tumorigenesis; Point mutation; Diethylnitrosamine; Tumors; Metastases; Glutamate-ammonia ligase; Colonies; catenin; Lung; Immunohistochemistry; Hepatocellular carcinoma; Signal transduction; Macaca mulatta DO - http://dx.doi.org/10.1177/0192623308327120 ER - TY - JOUR T1 - Fetal alcohol spectrum disorder. AN - 69943829; 19129565 AB - Maternal alcohol use during pregnancy leads to fetal alcohol spectrum disorder (FASD) in their children. FASD is characterized by typical facial features, growth retardation, intellectual dysfunction and behavioral problems. Alcohol is neurotoxic to the brain during the developmental stage. Behavioral problems in children with FASD start at an early age and progress to adulthood. It is an important preventable cause of intellectual dysfunction and behavioral problems. This article reviews current prevalence, clinical features, pathogenesis and differential diagnosis of FASD. It also highlights the need for physicians to be aware of this condition. Articles were searched on the internet using fetal alcohol syndrome, fetal alcohol spectrum disorders, women and alcohol. Following links were used to locate journals; EBSCO, OVID, Science Direct, PubMed and NIAAA. Alcohol consumption during pregnancy can lead to a spectrum of deficits. Though physical features are essential to make the diagnosis of FAS, it is important to note that neurocognitive and behavioural deficits can be present in the absence of physical features (alcohol related neurodevelopmental disorder or ARND). Because there is no known safe amount of alcohol consumption during pregnancy, abstinence from alcohol for women who are pregnant or planning a pregnancy must be strongly advised. JF - Indian pediatrics AU - Nayak, Raghavendra Bheemappa AU - Murthy, Pratima AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 29, India. rbn.psych@gmail.com Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 977 EP - 983 VL - 45 IS - 12 SN - 0019-6061, 0019-6061 KW - Index Medicus KW - India -- epidemiology KW - Risk Factors KW - Humans KW - Female KW - Prevalence KW - Pregnancy KW - Maternal Behavior KW - Risk-Taking KW - Alcohol Drinking -- adverse effects KW - Fetal Alcohol Spectrum Disorders -- epidemiology KW - Fetal Alcohol Spectrum Disorders -- etiology KW - Fetal Alcohol Spectrum Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69943829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+pediatrics&rft.atitle=Fetal+alcohol+spectrum+disorder.&rft.au=Nayak%2C+Raghavendra+Bheemappa%3BMurthy%2C+Pratima&rft.aulast=Nayak&rft.aufirst=Raghavendra&rft.date=2008-12-01&rft.volume=45&rft.issue=12&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Indian+pediatrics&rft.issn=00196061&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-20 N1 - Date created - 2009-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vasopressin does not mediate hypersensitivity of the hypothalamic pituitary adrenal axis during chronic stress. AN - 69934617; 19120128 AB - The hypothesis that vasopressin (VP) becomes the main mediator of pituitary corticotroph responsiveness during chronic hypothalamic pituitary adrenal (HPA) axis activation was tested by examining the effect of pharmacologic VP receptor blockade on the adrenocorticotropic hormone (ACTH) and corticosterone responses of 14-day repeatedly restrained rats. In spite of the increased vasopressinergic activity, repeatedly restrained rats showed lower ACTH and corticosterone responses to 10 min white noise compared with handled controls. These responses were unchanged by injection of the nonpeptide-selective V1b receptor antagonist SSR149415 i.v., 1 h before noise application. In contrast to noise stress, plasma ACTH responses to i.p. hypertonic saline injection were enhanced in the repeatedly restrained rats compared with handled controls, but responses were also unaffected by SSR149415 administered orally, daily 1 h before restraint. Since SSR149415 effectiveness was low, we used minipump infusion of the peptide V1 receptor antagonist, dGly[Phaa1,D-tyr(et), Lys, Arg]VP (V1-Ant) for 14 days, which effectively blocked ACTH responses to exogenous VP. Chronic V1-Ant infusion reduced plasma ACTH responses to i.p. hypertonic saline in handled controls but not in repeatedly restrained rats. These data suggest that the increased vasopressinergic activity characteristic of chronic stress plays roles other than mediating the hypersensitivity of the HPA axis to a novel stress. JF - Annals of the New York Academy of Sciences AU - Chen, Jun AU - Young, Sharla AU - Subburaju, Sivan AU - Sheppard, Jack AU - Kiss, Alexander AU - Atkinson, Helen AU - Wood, Susan AU - Lightman, Stafford AU - Serradeil-Le Gal, Claudine AU - Aguilera, Greti AD - Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 349 EP - 359 VL - 1148 KW - 1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide KW - 0 KW - Antidiuretic Hormone Receptor Antagonists KW - Indoles KW - Pyrrolidines KW - Receptors, Vasopressin KW - Vasopressins KW - 11000-17-2 KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Receptors, Vasopressin -- metabolism KW - Drinking KW - Animals KW - Restraint, Physical KW - Humans KW - Pyrrolidines -- metabolism KW - Rats KW - Body Weight KW - Eating KW - Rats, Sprague-Dawley KW - Corticosterone -- blood KW - Noise KW - Indoles -- metabolism KW - Male KW - Adrenocorticotropic Hormone -- blood KW - Hypothalamo-Hypophyseal System -- physiology KW - Vasopressins -- metabolism KW - Stress, Psychological KW - Pituitary-Adrenal System -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69934617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Vasopressin+does+not+mediate+hypersensitivity+of+the+hypothalamic+pituitary+adrenal+axis+during+chronic+stress.&rft.au=Chen%2C+Jun%3BYoung%2C+Sharla%3BSubburaju%2C+Sivan%3BSheppard%2C+Jack%3BKiss%2C+Alexander%3BAtkinson%2C+Helen%3BWood%2C+Susan%3BLightman%2C+Stafford%3BSerradeil-Le+Gal%2C+Claudine%3BAguilera%2C+Greti&rft.aulast=Chen&rft.aufirst=Jun&rft.date=2008-12-01&rft.volume=1148&rft.issue=&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=1749-6632&rft_id=info:doi/10.1196%2Fannals.1410.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2009-01-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1990 Nov 5;532(1-2):34-40 [2178035] Endocrinology. 1989 Jul;125(1):28-34 [2544403] Neuroendocrinology. 1991 Dec;54(6):635-8 [1664502] J Endocrinol. 1992 Sep;134(3):327-39 [1402543] Endocrinology. 1993 Jan;132(1):241-8 [8380375] Front Neuroendocrinol. 1993 Apr;14(2):76-122 [8387436] Front Neuroendocrinol. 1994 Dec;15(4):321-50 [7895891] Br J Pharmacol. 1995 Nov;116(5):2417-24 [8581278] Endocrinology. 1997 Oct;138(10):4351-7 [9322950] Endocrinology. 1998 Feb;139(2):443-50 [9449609] Brain Res Mol Brain Res. 1999 May 7;68(1-2):129-40 [10320790] Endocrinology. 1999 Aug;140(8):3623-32 [10433220] Proc Soc Exp Biol Med. 1954 Nov;87(2):318-24 [13237230] CNS Drug Rev. 2005 Spring;11(1):53-68 [15867952] Endocrinology. 2007 Feb;148(2):849-56 [17122081] J Neuroendocrinol. 2007 Mar;19(3):189-97 [17280592] J Neuroendocrinol. 2007 Jul;19(7):543-51 [17561882] Endocrinology. 2007 Jul;148(7):3102-10 [17412807] Peptides. 1990 Jan-Feb;11(1):59-63 [2160653] Neuroscience. 1999;94(3):797-802 [10579570] Regul Pept. 2000 Dec 22;96(1-2):23-9 [11102648] J Neuroendocrinol. 2001 Aug;13(8):711-23 [11489088] J Pharmacol Exp Ther. 2002 Mar;300(3):1122-30 [11861823] J Clin Invest. 2004 Jan;113(2):302-9 [14722621] Physiol Behav. 2004 Jun;81(4):557-68 [15178148] Brain Res Bull. 2004 Jul 15;63(6):521-30 [15249118] Nature. 1982 Sep 23;299(5881):355-7 [6287293] Proc Natl Acad Sci U S A. 1984 Mar;81(6):1883-7 [6369332] J Biol Chem. 1987 Jan 25;262(3):1129-36 [2433273] Endocrinology. 1988 Jul;123(1):396-405 [2838259] Endocrinology. 1989 Jun;124(6):3102-8 [2542009] Neuroendocrinology. 1991 Feb;53(2):150-9 [1849619] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1196/annals.1410.037 ER - TY - JOUR T1 - Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders. AN - 69934385; 18828796 AB - Existing studies of the association between age at first drink (AFD) and the risk of alcohol use disorders (AUD) suffer from inconsistent levels of control and designs that may inflate associations by failure to control for duration of exposure to risk. This study examined associations between AFD (ages <15 and 15-17 vs. 18+ years) and first incidence of DSM-IV alcohol dependence, abuse, and specific AUD criteria over a 3-year follow-up in a longitudinal study of U.S. drinkers 18 years of age and older at baseline (n = 22,316), controlling for duration of exposure, family history, and a wide range of baseline and childhood risk factors. After adjusting for all risk factors, the incidence of dependence was increased for AFD <15 years (OR = 1.38) and for women only with AFD at ages 15 to 17 (OR = 1.54). The incidence of abuse was increased at AFD <15 and 15 to 17 years (OR = 1.52 and 1.30, respectively). Most dependence criteria showed significant associations with AFD, but hazardous drinking and continued drinking despite interpersonal problems were the only abuse criteria to do so. All associations were nonsignificant after controlling for volume of consumption, except that AFD at all ages <18 combined was associated with a reduced likelihood of impaired control, and AFD at ages 15 to 17 was associated with lower odds of drinking more/longer than intended among heavy-volume drinkers. In a population of low-risk drinkers that excluded those with positive family histories, personality disorders, and childhood risk factors, there were strong associations between early AFD (<18) and the incidence of dependence (OR = 3.79) and continued drinking despite physical/psychological problems (OR = 2.71), but no association with incidence of abuse. There is a robust association between AFD and the risk of AUD that appears to reflect willful rather than uncontrolled heavy drinking, consistent with misuse governed by poor decision-making and/or reward-processing skills associated with impaired executive cognitive function (ECF). Additional research is needed to determine causality in the role of impaired ECF, including longitudinal studies with samples of low-risk adolescents. JF - Alcoholism, clinical and experimental research AU - Dawson, Deborah A AU - Goldstein, Risë B AU - Chou, S Patricia AU - Ruan, W June AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9304, USA. ddawson@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2149 EP - 2160 VL - 32 IS - 12 KW - Index Medicus KW - Young Adult KW - Age Factors KW - Risk Factors KW - Humans KW - Incidence KW - Follow-Up Studies KW - Longitudinal Studies KW - Adolescent KW - Male KW - Female KW - Alcohol-Related Disorders -- diagnosis KW - Alcohol Drinking -- psychology KW - Alcohol Drinking -- epidemiology KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcohol-Related Disorders -- psychology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69934385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Age+at+first+drink+and+the+first+incidence+of+adult-onset+DSM-IV+alcohol+use+disorders.&rft.au=Dawson%2C+Deborah+A%3BGoldstein%2C+Ris%C3%AB+B%3BChou%2C+S+Patricia%3BRuan%2C+W+June%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2008-12-01&rft.volume=32&rft.issue=12&rft.spage=2149&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=1530-0277&rft_id=info:doi/10.1111%2Fj.1530-0277.2008.00806.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-10-09 N1 - Date created - 2009-01-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Psychiatry. 1990 Nov;147(11):1537-41 [2221170] Mol Psychiatry. 2009 Nov;14(11):1051-66 [18427559] Addiction. 1999 Jun;94(6):843-55 [10665074] Am J Psychiatry. 2000 May;157(5):745-50 [10784467] Biol Psychiatry. 2000 Aug 15;48(4):265-75 [10960157] Am J Psychiatry. 2001 Jul;158(7):1084-90 [11431230] Alcohol Clin Exp Res. 2001 Aug;25(8):1156-65 [11505047] Alcohol Clin Exp Res. 2001 Aug;25(8):1166-73 [11515563] J Subst Abuse. 2001;13(4):493-504 [11775078] Drug Alcohol Depend. 2003 Jul 20;71(1):7-16 [12821201] Subst Use Misuse. 2003 Dec;38(14):1983-2016 [14677779] Alcohol Clin Exp Res. 2004 Sep;28(9):1379-87 [15365309] J Pers Soc Psychol. 1986 Dec;51(6):1173-82 [3806354] Am J Psychiatry. 1991 Nov;148(11):1501-4 [1928463] J Pers Soc Psychol. 1991 Oct;61(4):614-28 [1960653] Br J Addict. 1992 Aug;87(8):1199-204 [1511233] Addiction. 1993 Aug;88(8):1079-90 [8401162] Drug Alcohol Depend. 1995 Jul;39(1):37-44 [7587973] Alcohol Clin Exp Res. 1995 Aug;19(4):1018-23 [7485811] J Stud Alcohol. 1997 Jul;58(4):397-404 [9203121] Drug Alcohol Depend. 1997 Sep 25;47(3):195-205 [9306045] Drug Alcohol Depend. 1997 Sep 25;47(3):207-16 [9306046] J Subst Abuse. 1997;9:103-10 [9494942] J Stud Alcohol. 1998 Jan;59(1):32-42 [9498313] Recent Dev Alcohol. 1998;14:227-51 [9751948] Addiction. 1998 Oct;93(10):1511-20 [9926555] Alcohol Clin Exp Res. 1999 Jan;23(1):101-7 [10029209] Am J Addict. 1999 Summer;8(3):190-200 [10506900] Alcohol Health Res World. 1998;22(2):144-7 [15706789] Addiction. 2005 May;100(5):652-61 [15847623] Alcohol Clin Exp Res. 2005 Oct;29(10):1869-76 [16269917] Behav Genet. 2006 Mar;36(2):195-200 [16402286] Arch Pediatr Adolesc Med. 2006 Jul;160(7):739-46 [16818840] Addiction. 2007 Feb;102(2):216-25 [17222275] J Stud Alcohol Drugs. 2007 Mar;68(2):256-65 [17286344] Drug Alcohol Depend. 2007 Jul 10;89(2-3):139-44 [17227698] Alcohol Clin Exp Res. 2007 Jun;31(6):928-38 [17403069] Drug Alcohol Depend. 2007 Nov 2;91(1):26-39 [17553635] Arch Pediatr Adolesc Med. 2007 Oct;161(10):959-66 [17909139] Drug Alcohol Depend. 2008 Jan 1;92(1-3):27-36 [17706375] Neuropsychologia. 2008 Jan 31;46(2):714-26 [17996909] Alcohol Clin Exp Res. 2008 Mar;32(3):373-4 [18302721] Alcohol Clin Exp Res. 2008 Mar;32(3):386-94 [18302722] J Stud Alcohol. 1999 Nov;60(6):790-9 [10606491] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1530-0277.2008.00806.x ER - TY - JOUR T1 - The role of incretins in glucose homeostasis and diabetes treatment. AN - 69921890; 19074620 AB - Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within minutes after eating. One of their many physiological roles is to regulate the amount of insulin that is secreted after eating. In this manner, as well as others to be described in this review, their final common raison d'être is to aid in disposal of the products of digestion. There are two incretins, known as glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1), that share many common actions in the pancreas but have distinct actions outside of the pancreas. Both incretins are rapidly deactivated by an enzyme called dipeptidyl peptidase 4 (DPP4). A lack of secretion of incretins or an increase in their clearance are not pathogenic factors in diabetes. However, in type 2 diabetes (T2DM), GIP no longer modulates glucose-dependent insulin secretion, even at supraphysiological (pharmacological) plasma levels, and therefore GIP incompetence is detrimental to beta-cell function, especially after eating. GLP-1, on the other hand, is still insulinotropic in T2DM, and this has led to the development of compounds that activate the GLP-1 receptor with a view to improving insulin secretion. Since 2005, two new classes of drugs based on incretin action have been approved for lowering blood glucose levels in T2DM: an incretin mimetic (exenatide, which is a potent long-acting agonist of the GLP-1 receptor) and an incretin enhancer (sitagliptin, which is a DPP4 inhibitor). Exenatide is injected subcutaneously twice daily and its use leads to lower blood glucose and higher insulin levels, especially in the fed state. There is glucose-dependency to its insulin secretory capacity, making it unlikely to cause low blood sugars (hypoglycemia). DPP4 inhibitors are orally active and they increase endogenous blood levels of active incretins, thus leading to prolonged incretin action. The elevated levels of GLP-1 are thought to be the mechanism underlying their blood glucose-lowering effects. JF - Pharmacological reviews AU - Kim, Wook AU - Egan, Josephine M AD - National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 470 EP - 512 VL - 60 IS - 4 KW - Hypoglycemic Agents KW - 0 KW - Incretins KW - Peptides KW - Pyrazines KW - Triazoles KW - Venoms KW - exenatide KW - 9P1872D4OL KW - Glucose KW - IY9XDZ35W2 KW - Sitagliptin Phosphate KW - TS63EW8X6F KW - Index Medicus KW - Hypoglycemic Agents -- therapeutic use KW - Animals KW - Venoms -- therapeutic use KW - Pyrazines -- therapeutic use KW - Humans KW - Triazoles -- therapeutic use KW - Peptides -- therapeutic use KW - Glucose -- metabolism KW - Incretins -- physiology KW - Homeostasis -- physiology KW - Diabetes Mellitus -- physiopathology KW - Diabetes Mellitus -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69921890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+reviews&rft.atitle=The+role+of+incretins+in+glucose+homeostasis+and+diabetes+treatment.&rft.au=Kim%2C+Wook%3BEgan%2C+Josephine+M&rft.aulast=Kim&rft.aufirst=Wook&rft.date=2008-12-01&rft.volume=60&rft.issue=4&rft.spage=470&rft.isbn=&rft.btitle=&rft.title=Pharmacological+reviews&rft.issn=1521-0081&rft_id=info:doi/10.1124%2Fpr.108.000604 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-12 N1 - Date created - 2008-12-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gastroenterology. 2004 Aug;127(2):546-58 [15300587] Circulation. 2004 Aug 24;110(8):955-61 [15313949] Diabetes. 2004 Sep;53(9):2492-500 [15331566] Diabetes Care. 2004 Nov;27(11):2628-35 [15504997] Diabetes. 2004 Nov;53(11):2824-35 [15504962] J Clin Invest. 1967 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[10611300] Endocrinology. 2000 Feb;141(2):752-62 [10650957] Life Sci. 2000;66(2):91-103 [10666005] Endocrinology. 2000 Mar;141(3):1228-35 [10698200] Biochem Biophys Res Commun. 2000 Mar 16;269(2):331-5 [10708552] J Med Chem. 2000 May 4;43(9):1664-9 [10794683] Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1010-8 [10827002] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9 [10823914] Diabetes. 2000 May;49(5):741-8 [10905482] Diabetes. 2000 Jul;49(7):1156-64 [10909973] J Biol Chem. 2000 Sep 8;275(36):27989-99 [10869353] Biochem Pharmacol. 2002 Mar 1;63(5):993-6 [11911852] Diabetologia. 2002 Feb;45(2):195-202 [11935150] Exp Eye Res. 2002 Feb;74(2):231-6 [11950233] Bone. 2002 May;30(5):655-63 [11996901] Endocrinology. 2002 Jun;143(6):2303-13 [12021195] Endocrinology. 2002 Jun;143(6):2420-6 [12021207] J Endocrinol. 2002 Jun;173(3):465-73 [12065236] Nat Med. 2002 Jul;8(7):738-42 [12068290] J Clin Invest. 2002 Jul;110(1):43-52 [12093887] Am J Physiol Endocrinol Metab. 2002 Aug;283(2):E311-7 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Mar;145(3):1349-55 [14630721] Circulation. 2004 Mar 2;109(8):962-5 [14981009] Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E621-5 [14678954] J Endocrinol. 2004 Mar;180(3):389-98 [15012593] Nat Cell Biol. 2004 Mar;6(3):207-14 [15039777] Diabetes. 2004 May;53(5):1326-35 [15111503] Endocrinology. 2004 Jun;145(6):2687-95 [15001546] Diabetes Care. 2004 Jun;27(6):1335-42 [15161785] Diabetologia. 2004 May;47(5):806-15 [15095038] Diabetes Care. 2004 Jul;27(7):1692-8 [15220248] Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E199-206 [15271645] Bone. 2007 May;40(5):1352-60 [17321229] Int J Mol Med. 2007 Jun;19(6):961-6 [17487430] Gastroenterology. 2007 May;132(6):2131-57 [17498508] Diabetes. 2007 Jun;56(6):1551-8 [17360984] Diabetes. 2007 Jun;56(6):1671-9 [17369525] Diabetes Care. 2007 Jun;30(6):1487-93 [17353504] Diabetes Care. 2007 Jun;30(6):1608-10 [17372153] Eur J Clin Pharmacol. 2007 Jul;63(7):677-86 [17486328] Clin Pharmacokinet. 2007;46(7):577-88 [17596103] JAMA. 2007 Jul 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Endocrinology. 1985 Sep;117(3):817-23 [2862020] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/pr.108.000604 ER - TY - JOUR T1 - Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore. AN - 69916144; 19006141 AB - A search query consisting of two aromatic centers and two cationic centers was defined based on previously identified small molecule inhibitors of the botulinum neurotoxin serotype A light chain (BoNT/A LC) and used to mine the National Cancer Institute Open Repository. Ten small molecule hits were identified, and upon testing, three demonstrated inhibitory activity. Of these, one was structurally unique, possessing a rigid diazachrysene scaffold. The steric limitations of the diazachrysene imposed a separation between the overlaps of previously identified inhibitors, revealing an extended binding mode. As a result, the pharmacophore for BoNT/A LC inhibition has been modified to encompass three zones. To demonstrate the utility of this model, a novel three-zone inhibitor was mined and its activity was confirmed. JF - ChemMedChem AU - Hermone, Ann R AU - Burnett, James C AU - Nuss, Jonathan E AU - Tressler, Lyal E AU - Nguyen, Tam L AU - Solaja, Bogdan A AU - Vennerstrom, Jonathan L AU - Schmidt, James J AU - Wipf, Peter AU - Bavari, Sina AU - Gussio, Rick AD - Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc. National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1905 EP - 1912 VL - 3 IS - 12 KW - Chrysenes KW - 0 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Imaging, Three-Dimensional KW - Computer Simulation KW - Databases, Factual KW - Drug Design KW - Structure-Activity Relationship KW - Models, Molecular KW - Chrysenes -- pharmacology KW - Chrysenes -- chemistry KW - Botulinum Toxins, Type A -- antagonists & inhibitors KW - Botulinum Toxins, Type A -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69916144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ChemMedChem&rft.atitle=Three-dimensional+database+mining+identifies+a+unique+chemotype+that+unites+structurally+diverse+botulinum+neurotoxin+serotype+A+inhibitors+in+a+three-zone+pharmacophore.&rft.au=Hermone%2C+Ann+R%3BBurnett%2C+James+C%3BNuss%2C+Jonathan+E%3BTressler%2C+Lyal+E%3BNguyen%2C+Tam+L%3BSolaja%2C+Bogdan+A%3BVennerstrom%2C+Jonathan+L%3BSchmidt%2C+James+J%3BWipf%2C+Peter%3BBavari%2C+Sina%3BGussio%2C+Rick&rft.aulast=Hermone&rft.aufirst=Ann&rft.date=2008-12-01&rft.volume=3&rft.issue=12&rft.spage=1905&rft.isbn=&rft.btitle=&rft.title=ChemMedChem&rft.issn=1860-7187&rft_id=info:doi/10.1002%2Fcmdc.200800241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cmdc.200800241 ER - TY - JOUR T1 - Cognitive remediation in the treatment of stimulant abuse disorders: a research agenda. AN - 69901640; 19086769 AB - Treatment of substance abuse disorders is often characterized by high dropout rates. Patients who fail to complete a treatment course often are worse at follow-up than those patients who received the full treatment course. Cognitive deficits, including impulsivity, have been noted as a major determinant of treatment retention and successful outcomes. This review summarizes the recent literature on cognitive deficits in stimulant users and their remediation. Cognitive deficits can be remediated through computer-assisted cognitive rehabilitation in residential settings. A few studies have shown this can be transferred to the outpatient setting although much research remains to be done in this setting. Pharmacological remediation of cognitive deficits is a new target for medications development in the treatment of substance abuse disorders. Psychiatric disorders; for example, attention deficit hyperactivity disorder, are amenable to pharmacological remediation of cognitive deficits. Several cognitive deficits (set-shifting, attentional bias, reversal learning, impulsivity, and risky decision making) and their possible remediation with pharmacological agents are presented in the review. Recommendations for the research agenda include comments on testing hierarchies, clinical trial design issues, and types of pharmacological agents. (c) 2008 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Vocci, Frank J AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA. fvocci@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 484 EP - 497 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Central Nervous System Stimulants KW - 0 KW - Index Medicus KW - Impulsive Behavior -- complications KW - Humans KW - Patient Dropouts KW - Treatment Outcome KW - Impulsive Behavior -- therapy KW - Central Nervous System Stimulants -- adverse effects KW - Therapy, Computer-Assisted -- methods KW - Cognitive Therapy -- methods KW - Substance-Related Disorders -- physiopathology KW - Cognition Disorders -- therapy KW - Substance-Related Disorders -- rehabilitation KW - Cognition Disorders -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69901640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Cognitive+remediation+in+the+treatment+of+stimulant+abuse+disorders%3A+a+research+agenda.&rft.au=Vocci%2C+Frank+J&rft.aulast=Vocci&rft.aufirst=Frank&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014101 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1037/a0014101 ER - TY - JOUR T1 - Introduction to a symposium on recent advances in the development of medications for drug abuse treatment in honor of Jack H. Mendelson, M.D. AN - 69901562; 19086765 JF - Experimental and clinical psychopharmacology AU - Acri, Jane B AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA. jacri@nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 443 EP - 445 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Index Medicus KW - Mendelson KW - History, 21st Century KW - History, 20th Century KW - Humans KW - Clinical Trials as Topic KW - Male KW - Alcoholism -- rehabilitation KW - Alcoholism -- history KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69901562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Introduction+to+a+symposium+on+recent+advances+in+the+development+of+medications+for+drug+abuse+treatment+in+honor+of+Jack+H.+Mendelson%2C+M.D.&rft.au=Acri%2C+Jane+B&rft.aulast=Acri&rft.aufirst=Jane&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014102 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - People - Mendelson N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Mendelson DO - http://dx.doi.org/10.1037/a0014102 ER - TY - JOUR T1 - Dual dopamine/serotonin releasers: potential treatment agents for stimulant addiction. AN - 69897932; 19086767 AB - "Agonist therapy" for cocaine and methamphetamine addiction involves administration of stimulant-like medications (e.g., monoamine releasers) to reduce withdrawal symptoms and prevent relapse. A significant problem with this strategy is that many candidate medications possess abuse liability because of activation of mesolimbic dopamine (DA) neurons in the brain. One way to reduce DA-mediated abuse liability of candidate drugs is to add in serotonin (5-HT) releasing properties, since substantial evidence shows that 5-HT neurons provide an inhibitory influence over mesolimbic DA neurons. This article addresses several key issues related to the development of dual DA/5-HT releasers for the treatment of substance use disorders. First, the authors briefly summarize the evidence supporting a dual deficit in DA and 5-HT function during withdrawal from chronic cocaine or alcohol abuse. Second, the authors discuss data demonstrating that 5HT release can dampen DA-mediated stimulant effects, and the "antistimulant" role of 5-HT-sub(2C) receptors is considered. Next, the mechanisms underlying potential adverse effects of 5-HT releasers are described. Finally, the authors discuss recently published data with PAL-287, a novel nonamphetamine DA/5-HT releasing agent that suppresses cocaine self-administration but lacks positive reinforcing properties. It is concluded that DA/5-HT releasers could be useful therapeutic adjuncts for the treatment of cocaine and alcohol addictions, as well as for obesity, attention-deficit disorder, and depression. (c) 2008 APA, all rights reserved. JF - Experimental and clinical psychopharmacology AU - Rothman, Richard B AU - Blough, Bruce E AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, IRP/NIDA/NIH, Clinical Psychopharmacology Section, Suite 4500, Triad Building, 333 Cassell Drive, Baltimore, MD 21224, USA. rrothman@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 458 EP - 474 VL - 16 IS - 6 SN - 1064-1297, 1064-1297 KW - Central Nervous System Stimulants KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Humans KW - Cocaine-Related Disorders -- drug therapy KW - Dopamine -- metabolism KW - Behavior, Addictive -- drug therapy KW - Serotonin -- metabolism KW - Substance-Related Disorders -- physiopathology KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance-Related Disorders -- drug therapy KW - Substance Withdrawal Syndrome -- drug therapy KW - Central Nervous System Stimulants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69897932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Dual+dopamine%2Fserotonin+releasers%3A+potential+treatment+agents+for+stimulant+addiction.&rft.au=Rothman%2C+Richard+B%3BBlough%2C+Bruce+E%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2008-12-01&rft.volume=16&rft.issue=6&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/10.1037%2Fa0014103 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-03 N1 - Date created - 2008-12-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Heart Valve Dis. 2000 May;9(3):454-8 [10888105] Psychopharmacology 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[11071707] Chest. 2000 Nov;118(5):1496-7 [11083709] Neuroscience. 2007 Apr 25;146(1):286-97 [17367945] Neuroscience. 2007 Jun 8;146(4):1677-88 [17467185] Curr Opin Neurobiol. 2007 Jun;17(3):304-12 [17509873] Trends Pharmacol Sci. 2007 Jul;28(7):316-25 [17573127] Am J Cardiol. 2007 Nov 1;100(9):1442-5 [17950805] Neuropsychopharmacology. 2008 Jan;33(1):166-80 [17805308] J Pharmacol Exp Ther. 2008 Feb;324(2):791-7 [18032571] Am J Ther. 2010 Nov-Dec;17(6):596-603 [19352140] Br J Pharmacol. 1997 Dec;122(7):1455-63 [9421295] Pharmacol Biochem Behav. 1998 Mar;59(3):709-15 [9512076] Alcohol Clin Exp Res. 1998 Feb;22(1):3-9 [9514280] Am J Addict. 1998 Spring;7(2):142-55 [9598218] Ann N Y Acad Sci. 1998 May 30;844:59-74 [9668665] Synapse. 1998 Sep;30(1):107-11 [9704887] Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):87-96 [9716932] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1037/a0014103 ER - TY - JOUR T1 - Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs. AN - 69892991; 19075617 AB - Medicinal use of natural products such as extracts of plants has existed for many years in China and in other countries and they are now available worldwide. Citrus fruit juices are consumed on a daily basis around the world. Modern medicine provides well-tested compounds or drugs for most sicknesses. However, the simultaneous consumption of plant extracts, food supplements, and fruit juices with drugs can create metabolic aberrations in humans. Interactions between drugs used simultaneously are regulated by government agencies. Not regulated, but warned against in drug inserts are potential interactions between drugs and food and food-additives containing certain compounds with potential side effects. Summarized here are the results of investigations that point out possible interactions at the level of transporter molecules by drugs and compounds of natural origin. These transporter molecules play important roles in absorption in the intestines, at the blood brain barrier, in the liver, the kidney and in some other parts of the human body. Drugs and metabolites pass through these pumps and may compete with compounds from food supplements. The most studied natural compounds that are potential modulators of these transport molecules are flavonoids, found in fruit juices, vegetables, flowers and tea. Mycotoxins found in cereal grains are also shown to modulate transporter proteins. We detail here how such constituents of natural origin were shown to modulate three types of the major transporter molecules, P-glycoprotein (ABCB1), multidrug resistance proteins (ABCCs) and breast cancer resistance protein (ABCG2). Interference of these natural compounds with drugs at the transporter level is also discussed. JF - Current drug metabolism AU - Aszalos, Adorjan AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Room 2112, Bethesda, MD 20892, USA. aszalosa@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1010 EP - 1018 VL - 9 IS - 10 SN - 1389-2002, 1389-2002 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Multidrug Resistance-Associated Proteins KW - Neoplasm Proteins KW - P-Glycoprotein KW - multidrug resistance-associated protein 2 KW - 4AF605U6JN KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Multidrug Resistance-Associated Proteins -- physiology KW - P-Glycoprotein -- physiology KW - Neoplasm Proteins -- physiology KW - Humans KW - Citrus paradisi KW - ATP-Binding Cassette Transporters -- physiology KW - Food-Drug Interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69892991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+metabolism&rft.atitle=Role+of+ATP-binding+cassette+%28ABC%29+transporters+in+interactions+between+natural+products+and+drugs.&rft.au=Aszalos%2C+Adorjan&rft.aulast=Aszalos&rft.aufirst=Adorjan&rft.date=2008-12-01&rft.volume=9&rft.issue=10&rft.spage=1010&rft.isbn=&rft.btitle=&rft.title=Current+drug+metabolism&rft.issn=13892002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metal catalyzed oxidation of alpha-synuclein--a role for oligomerization in pathology? AN - 69891950; 19075587 AB - A number of studies have demonstrated a role for transition metals and oxidative stress in the etiology of Parkinson's disease (PD). Genetic and biochemical evidence also clearly links the protein alpha-synuclein (alphaSyn) to PD and a number of associated diseases. In these "synucleinopathies", alphaSyn is deposited, often in oligomerized forms, as cytoplasmic inclusions known as Lewy bodies and Lewy neurites. alphaSyn cross-linking/oligomerization can occur via a number of processes, most stimulated by metal catalyzed oxidation (MCO). In PD, the increased sensitivity of midbrain neurons expressing high levels of oxidizable catecholamines may provide one clue to account for degeneration of these neurons. In other regions of the nervous system that develop Lewy body pathology, the mode of alphaSyn oligomerization is less clear. Thus, the relationship between alphaSyn and MCO, either direct or indirect, represents a particular concern for possible treatment of these various diseases. JF - Current Alzheimer research AU - Cole, N B AD - Laboratory of Biochemistry, National Heart Lung and Blood Institute, 50 South Drive MSC 8012, Bethesda, Maryland 20892, USA. ncole@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 599 EP - 606 VL - 5 IS - 6 SN - 1567-2050, 1567-2050 KW - Metals KW - 0 KW - alpha-Synuclein KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Humans KW - Brain Chemistry -- drug effects KW - Lipid Peroxidation -- drug effects KW - Catalysis KW - Brain Chemistry -- physiology KW - alpha-Synuclein -- chemistry KW - Neurodegenerative Diseases -- metabolism KW - alpha-Synuclein -- toxicity KW - Neurodegenerative Diseases -- pathology KW - Metals -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69891950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=Metal+catalyzed+oxidation+of+alpha-synuclein--a+role+for+oligomerization+in+pathology%3F&rft.au=Cole%2C+N+B&rft.aulast=Cole&rft.aufirst=N&rft.date=2008-12-01&rft.volume=5&rft.issue=6&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=15672050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. AN - 69891348; 19075603 AB - Glucocerebrosidase (GC) catalyzes the hydrolysis of beta-glucocerebroside to glucose and ceramide in lysosomes. Mutations in the glucocerebrosidase gene (GBA) result in Gaucher disease, an autosomal recessive lysosomal storage disorder. Many of the mutations encountered in patients with Gaucher disease are missense alterations that may cause misfolding, decreased stability and/or mistrafficking of this lysosomal protein. Some inhibitors of GC have been shown to act as chemical chaperones, stabilizing the conformation of mutant proteins and thus restoring their function. High throughput screening (HTS) of small molecule libraries for such compounds with potential for chaperone therapy requires an accurate, reproducible and sensitive assay method. We have adapted and optimized two fluorogenic GC enzyme assays and miniaturized them into the 1536-well plate format for HTS. The two substrates, 4-methylumbelliferyl beta-D-glucopyranoside and resorufin beta-D-glucopyranoside, have K(m) values of 768 microM and 33 microM, respectively, and different emission spectra. Paired screening with the two assays helps to eliminate false inference of activity due to autofluorescence or fluorescence quenching by the screened compounds. Test screens with the LOPAC library indicated that both assays were robust for HTS, and gave comparable results for GC inhibitor activities. These two assays can be used to identify both GC activators and inhibitors with potential therapeutic value. JF - Combinatorial chemistry & high throughput screening AU - Urban, Daniel J AU - Zheng, Wei AU - Goker-Alpan, Ozlem AU - Jadhav, Ajit AU - Lamarca, Mary E AU - Inglese, James AU - Sidransky, Ellen AU - Austin, Christopher P AD - Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3708, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 817 EP - 824 VL - 11 IS - 10 SN - 1386-2073, 1386-2073 KW - Enzyme Inhibitors KW - 0 KW - Taurocholic Acid KW - 5E090O0G3Z KW - Glucosylceramidase KW - EC 3.2.1.45 KW - Dimethyl Sulfoxide KW - YOW8V9698H KW - Index Medicus KW - Spectrometry, Fluorescence KW - Kinetics KW - Hydrogen-Ion Concentration KW - Enzyme Inhibitors -- pharmacology KW - Miniaturization KW - Substrate Specificity KW - Inhibitory Concentration 50 KW - Glucosylceramidase -- analysis KW - Glucosylceramidase -- metabolism KW - Glucosylceramidase -- antagonists & inhibitors KW - Drug Evaluation, Preclinical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69891348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Combinatorial+chemistry+%26+high+throughput+screening&rft.atitle=Optimization+and+validation+of+two+miniaturized+glucocerebrosidase+enzyme+assays+for+high+throughput+screening.&rft.au=Urban%2C+Daniel+J%3BZheng%2C+Wei%3BGoker-Alpan%2C+Ozlem%3BJadhav%2C+Ajit%3BLamarca%2C+Mary+E%3BInglese%2C+James%3BSidransky%2C+Ellen%3BAustin%2C+Christopher+P&rft.aulast=Urban&rft.aufirst=Daniel&rft.date=2008-12-01&rft.volume=11&rft.issue=10&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=Combinatorial+chemistry+%26+high+throughput+screening&rft.issn=13862073&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-09-09 N1 - Date created - 2008-12-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15428-33 [12434014] Hum Mutat. 2008 May;29(5):567-83 [18338393] Mol Genet Metab. 2004 Sep-Oct;83(1-2):6-15 [15464415] Clin Chim Acta. 1975 May 1;60(3):391-6 [806404] Clin Chim Acta. 1976 Jul 15;70(2):247-57 [8226] Arch Biochem Biophys. 1976 Aug;175(2):569-82 [958319] Brain Res. 1977 Feb 18;122(2):325-35 [13910] Clin Chim Acta. 1978 Oct 16;89(2):293-9 [361294] Biochem J. 1980 Mar 1;185(3):583-91 [7387624] Clin Chem. 1982 Apr;28(4 Pt 1):569-77 [6804115] Anal Biochem. 1983 Apr 15;130(2):521-6 [6869839] Biochemistry. 1985 Jul 2;24(14):3530-9 [3929833] J Neurochem. 1990 Feb;54(2):699-702 [1967633] Cell Biochem Funct. 1993 Sep;11(3):167-77 [8403230] Agents Actions. 1993 Nov;40(3-4):186-90 [8023742] Biochim Biophys Acta. 1994 Jul 14;1213(2):176-82 [8025128] Anal Biochem. 1997 May 1;247(2):268-71 [9177687] Baillieres Clin Haematol. 1997 Dec;10(4):621-34 [9497855] Hepatology. 1998 Jul;28(1):156-63 [9657108] J Pathol. 1999 Aug;188(4):407-14 [10440752] J Biol Chem. 2005 Jun 24;280(25):23815-9 [15817452] Hum Mol Genet. 2005 Aug 15;14(16):2387-98 [16000318] Blood Cells Mol Dis. 2005 Sep-Oct;35(2):268-76 [16039881] J Biomol Screen. 2006 Feb;11(1):29-39 [16234337] Cell Mol Life Sci. 2006 May;63(10):1179-92 [16568247] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Nat Chem Biol. 2007 Feb;3(2):101-7 [17187079] Mol Genet Metab. 2007 Feb;90(2):122-5 [17084653] Expert Opin Pharmacother. 2007 Mar;8(4):427-35 [17309337] J Biomol Screen. 2007 Mar;12(2):203-10 [17208922] Nat Chem Biol. 2007 Aug;3(8):466-79 [17637779] Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7 [17670938] Trends Pharmacol Sci. 2003 Jul;24(7):355-60 [12871668] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical evaluation of paroxetine in post-traumatic stress disorder (PTSD): 52-week, non-comparative open-label study for clinical use experience. AN - 69876631; 19068000 AB - The present study was a 52-week, non-comparative, open-label study of flexible dose paroxetine (20-40 mg) in 52 Japanese post-traumatic stress disorder (PTSD) patients in order to obtain clinical experience regarding efficacy and safety in regular clinical practice. Efficacy was measured using the Clinician-Administered PTSD Scale One Week Symptom Status Version (CAPS-SX). The mean change from baseline in CAPS-SX total score was -19.1, -22.8 and -32.3 at weeks 4, 12 and 52, respectively, and that in the Clinical Global Impression (CGI) Severity of Illness score was -1.1 at week 12 and -1.7 at week 52. A total of 46.9% were CGI responders at week 12, while 67.3% were improved on the CGI at week 52. Of 52 subjects who entered into the drug treatment, 25 completed the study. Only one patient withdrew from the study due to lack of efficacy. In patients who were rated as 'moderately ill' or less at baseline, the proportion of CGI responders at end-point was higher at a dose of 20 mg/day than at higher doses, whereas in patients rated as 'markedly ill' or more, it was higher at 30 and 40 mg/day, suggesting that severely ill patients could benefit from higher doses. Paroxetine appeared generally tolerated in short- and long-term use, and the safety profile in this study was consistent with international trials and other Japanese populations (i.e. patients suffering from depression, panic disorder or obsessive-compulsive disorder). Although the study was not conducted in double-blind fashion, the current findings suggest that paroxetine may contribute to clinically meaningful improvement that is maintained during long-term use and is generally well tolerated. JF - Psychiatry and clinical neurosciences AU - Kim, Yoshiharu AU - Asukai, Nozomu AU - Konishi, Takako AU - Kato, Hiroshi AU - Hirotsune, Hideto AU - Maeda, Masaharu AU - Inoue, Hirotaka AU - Narita, Hiroyasu AU - Iwasaki, Masaru AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 646 EP - 652 VL - 62 IS - 6 KW - Serotonin Uptake Inhibitors KW - 0 KW - Paroxetine KW - 41VRH5220H KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Treatment Outcome KW - Cluster Analysis KW - Male KW - Female KW - Paroxetine -- administration & dosage KW - Serotonin Uptake Inhibitors -- administration & dosage KW - Stress Disorders, Post-Traumatic -- psychology KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Paroxetine -- therapeutic use KW - Paroxetine -- adverse effects KW - Stress Disorders, Post-Traumatic -- drug therapy KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69876631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+and+clinical+neurosciences&rft.atitle=Clinical+evaluation+of+paroxetine+in+post-traumatic+stress+disorder+%28PTSD%29%3A+52-week%2C+non-comparative+open-label+study+for+clinical+use+experience.&rft.au=Kim%2C+Yoshiharu%3BAsukai%2C+Nozomu%3BKonishi%2C+Takako%3BKato%2C+Hiroshi%3BHirotsune%2C+Hideto%3BMaeda%2C+Masaharu%3BInoue%2C+Hirotaka%3BNarita%2C+Hiroyasu%3BIwasaki%2C+Masaru&rft.aulast=Kim&rft.aufirst=Yoshiharu&rft.date=2008-12-01&rft.volume=62&rft.issue=6&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Psychiatry+and+clinical+neurosciences&rft.issn=1440-1819&rft_id=info:doi/10.1111%2Fj.1440-1819.2008.01862.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1440-1819.2008.01862.x ER - TY - JOUR T1 - K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3'-azido-3'-deoxythymidine. AN - 69875691; 18800350 AB - A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg 3'-azido-3'-deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18-19 days) [National Toxicology Program,2006]. The incidence of alveolar/bronchiolar adenomas and carcinomas in the 200 and 300 mg/kg groups was significantly higher (P = 0.027 and 0.007, respectively) in male offspring, but not in females (P = 0.338 and 0.315, respectively). The purpose of the present study was to evaluate K-ras mutation status in lung tumors from the female offspring in AZT exposed groups and to determine whether at the molecular level there were signature K-ras mutations in lung tumors that were different from spontaneous tumors. K-ras mutation was detected by cycle sequencing of polymerase chain reaction (PCR)-amplified DNA, isolated from formalin-fixed, paraffin-embedded lung tumors. K-ras mutations were detected in 17 of 28 (61%) lung tumors from the female offspring in AZT exposed groups. No K-ras mutations were detected in the 8 tumors examined from the female control group. The predominant mutations were Codon 12 G-->T transversions in the 50, 100, and 300 mg/kg groups, and Codon 12 G-->C transversions in the 200 and 300 mg/kg groups. K-ras Codon 12 G-->T transversions (TGT mutations) may be induced by oxidative DNA damage and 8-oxoguanine (8-oxoG), while K-ras Codon 12 G-->C transversions (CGT mutations) may be due to further oxidative lesions of guanine and 8-oxoG. JF - Environmental and molecular mutagenesis AU - Koujitani, Takatoshi AU - Ton, Tai-Vu T AU - Lahousse, Stephanie A AU - Hong, Hue-Hua L AU - Wakamatsu, Nobuko AU - Sills, Robert C AD - Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 720 EP - 726 VL - 49 IS - 9 KW - Zidovudine KW - 4B9XT59T7S KW - Index Medicus KW - Maternal Exposure -- adverse effects KW - Prenatal Exposure Delayed Effects -- etiology KW - Animals KW - Sex Factors KW - Mice KW - Male KW - Female KW - Prenatal Exposure Delayed Effects -- genetics KW - Pregnancy KW - Mutation -- drug effects KW - Lung Neoplasms -- etiology KW - Zidovudine -- toxicity KW - Genes, ras -- genetics KW - Lung Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69875691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=K-ras+cancer+gene+mutations+in+lung+tumors+from+female+Swiss+%28CD-1%29+mice+exposed+transplacentally+to+3%27-azido-3%27-deoxythymidine.&rft.au=Koujitani%2C+Takatoshi%3BTon%2C+Tai-Vu+T%3BLahousse%2C+Stephanie+A%3BHong%2C+Hue-Hua+L%3BWakamatsu%2C+Nobuko%3BSills%2C+Robert+C&rft.aulast=Koujitani&rft.aufirst=Takatoshi&rft.date=2008-12-01&rft.volume=49&rft.issue=9&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20420 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20420 ER - TY - JOUR T1 - Correlates of human papillomavirus viral load with infection site in asymptomatic men. AN - 69872936; 19064573 AB - Numerous studies have evaluated human papillomavirus (HPV) DNA load in women, especially HPV-16 viral load, and its role in cervical carcinogenicity. Few studies have examined HPV viral load in men, none among asymptomatic men. The aim of the current study is to quantify HPV-16 viral load in male anogenital specimens and to explore its correlates with anatomic sites. Two-hundred and ninety-four specimens from 42 men who tested positive for HPV-16 at one or more anatomic sites were evaluated. HPV DNA was detected with PGMY 09/11 primer and genotyped with reverse line blot assay followed by HPV-16 viral quantification using type-specific real-time PCR assay (TaqMan). The quantitative PCR assay showed a higher sensitivity in HPV-16 viral DNA detection compared with the reverse line blot assay. Viral load varied significantly by anatomic site (P = 0.019). Penile shaft specimens had significantly higher viral load than any other anatomic site evaluated except for the anal canal. HPV-16 viral load was positively correlated between proximal anatomic sites: perianal and anal canal (P = 0.003), perianal and scrotum (P = 0.011), scrotum and glans/corona (P = 0.045), and scrotum and penile shaft (P = 0.037). In conclusion, the penile shaft seemed to be the preferred site for HPV-16 viral replication. Viral load correlation between proximal sites suggested a possible autoinoculation in male HPV transmission. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Flores, Roberto AU - Lu, Beibei AU - Beibei, Lu AU - Nielson, Carrie AU - Abrahamsen, Martha AU - Wolf, Kyle AU - Lee, Ji-Hyun AU - Harris, Robin B AU - Giuliano, Anna R AD - Cancer Prevention Fellowship Program, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS Suite T-41, Bethesda, MD 20892-7105, USA. rflores@jhsph.edu Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3573 EP - 3576 VL - 17 IS - 12 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Virus Replication KW - Viral Load KW - Sensitivity and Specificity KW - Genotype KW - Cross-Sectional Studies KW - Penis -- virology KW - Humans KW - Adult KW - Reverse Transcriptase Polymerase Chain Reaction KW - Statistics, Nonparametric KW - Male KW - Human papillomavirus 16 -- isolation & purification KW - Papillomavirus Infections -- virology KW - Human papillomavirus 16 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69872936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Correlates+of+human+papillomavirus+viral+load+with+infection+site+in+asymptomatic+men.&rft.au=Flores%2C+Roberto%3BLu%2C+Beibei%3BBeibei%2C+Lu%3BNielson%2C+Carrie%3BAbrahamsen%2C+Martha%3BWolf%2C+Kyle%3BLee%2C+Ji-Hyun%3BHarris%2C+Robin+B%3BGiuliano%2C+Anna+R&rft.aulast=Flores&rft.aufirst=Roberto&rft.date=2008-12-01&rft.volume=17&rft.issue=12&rft.spage=3573&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0467 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-27 N1 - Date created - 2008-12-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):216 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0467 ER - TY - JOUR T1 - High incidence of oral dysesthesias on a trial of gefitinib, Paclitaxel, and concurrent external beam radiation for locally advanced head and neck cancers. AN - 69871530; 19060587 AB - To report a high incidence of oral mucosal dysesthesia occurring in patients on a pilot study of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa) in combination with paclitaxel (Taxol) and external beam radiation therapy for the treatment of locally advanced squamous cell carcinoma of the head and neck. Nine patients were enrolled on a pilot phase I trial of oral gefitinib 250 mg/d with 6 weekly doses of paclitaxel (36 or 45 mg/m) and concurrent radiation therapy [66-76 Gray (Gy)]. All had stage III/IVA-B squamous cell carcinoma of the head and neck. Patients were evaluated twice weekly by physicians and daily by nursing for adverse events. Six of 9 patients (67%) developed a grade 3 "burning" quality oral dysesthesia. These patients received at least 50 Gy (range 50-70 Gy) to the oral tongue. The patients without grade 3 oral dysesthesia received less than 50 Gy radiation to the oral tongue. The oral dysesthesia was exacerbated by the ingestion of neutral pH liquids such as water. Of the 6 patients, all eventually developed common toxicity criteria grade 3/4 mucositis; however, symptoms continued after resolution of the mucositis. Gabapentin (Neurontin) was administered to 2 patients as a treatment for painful mucosal neuropathy. Both patients had near resolution of symptoms despite the evolution of oral mucositis. Development of "burning"-type oral dysesthesia occurred in patients treated with the combination of gefitinib, paclitaxel, and external beam radiation of the oral tongue. This dysesthesia was improved by the use of gabapentin. JF - American journal of clinical oncology AU - Sharp, Hadley AU - Morris, John C AU - Van Waes, Carter AU - Gius, David AU - Cooley-Zgela, Theresa AU - Singh, Anurag K AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 557 EP - 560 VL - 31 IS - 6 KW - Amines KW - 0 KW - Anticonvulsants KW - Cyclohexanecarboxylic Acids KW - Quinazolines KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - gabapentin KW - 6CW7F3G59X KW - Paclitaxel KW - P88XT4IS4D KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Prognosis KW - Aged KW - Amines -- therapeutic use KW - Cyclohexanecarboxylic Acids -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Quinazolines -- administration & dosage KW - gamma-Aminobutyric Acid -- therapeutic use KW - Adult KW - Incidence KW - Middle Aged KW - Female KW - Male KW - Radiation Injuries -- drug therapy KW - Paresthesia -- chemically induced KW - Head and Neck Neoplasms -- pathology KW - Paresthesia -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Stomatitis -- drug therapy KW - Head and Neck Neoplasms -- drug therapy KW - Radiotherapy -- adverse effects KW - Stomatitis -- chemically induced KW - Head and Neck Neoplasms -- therapy KW - Carcinoma, Squamous Cell -- pathology KW - Head and Neck Neoplasms -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy KW - Radiation Injuries -- etiology KW - Carcinoma, Squamous Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69871530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=High+incidence+of+oral+dysesthesias+on+a+trial+of+gefitinib%2C+Paclitaxel%2C+and+concurrent+external+beam+radiation+for+locally+advanced+head+and+neck+cancers.&rft.au=Sharp%2C+Hadley%3BMorris%2C+John+C%3BVan+Waes%2C+Carter%3BGius%2C+David%3BCooley-Zgela%2C+Theresa%3BSingh%2C+Anurag+K&rft.aulast=Sharp&rft.aufirst=Hadley&rft.date=2008-12-01&rft.volume=31&rft.issue=6&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=1537-453X&rft_id=info:doi/10.1097%2FCOC.0b013e318172d5de LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-13 N1 - Date created - 2008-12-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/COC.0b013e318172d5de ER - TY - JOUR T1 - Small toxic proteins and the antisense RNAs that repress them. AN - 69866027; 19052321 AB - There has been a great expansion in the number of small regulatory RNAs identified in bacteria. Some of these small RNAs repress the synthesis of potentially toxic proteins. Generally the toxin proteins are hydrophobic and less than 60 amino acids in length, and the corresponding antitoxin small RNA genes are antisense to the toxin genes or share long stretches of complementarity with the target mRNAs. Given their short length, only a limited number of these type I toxin-antitoxin loci have been identified, but it is predicted that many remain to be found. Already their characterization has given insights into regulation by small RNAs, has suggested functions for the small toxic proteins at the cell membrane, and has led to practical applications for some of the type I toxin-antitoxin loci. JF - Microbiology and molecular biology reviews : MMBR AU - Fozo, Elizabeth M AU - Hemm, Matthew R AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 18 Library Drive, Bethesda, MD 20892-5430, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 579 EP - 89, Table of Contents VL - 72 IS - 4 KW - Antitoxins KW - 0 KW - Bacterial Toxins KW - RNA, Antisense KW - RNA, Bacterial KW - Index Medicus KW - Antitoxins -- genetics KW - Enterobacteriaceae -- genetics KW - Chromosomes, Bacterial -- genetics KW - Enterobacteriaceae -- metabolism KW - Gene Expression Regulation, Bacterial KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- antagonists & inhibitors KW - Bacterial Toxins -- metabolism KW - RNA, Bacterial -- metabolism KW - RNA, Antisense -- metabolism KW - RNA, Bacterial -- genetics KW - RNA, Antisense -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69866027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+and+molecular+biology+reviews+%3A+MMBR&rft.atitle=Small+toxic+proteins+and+the+antisense+RNAs+that+repress+them.&rft.au=Fozo%2C+Elizabeth+M%3BHemm%2C+Matthew+R%3BStorz%2C+Gisela&rft.aulast=Fozo&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=72&rft.issue=4&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Microbiology+and+molecular+biology+reviews+%3A+MMBR&rft.issn=1098-5557&rft_id=info:doi/10.1128%2FMMBR.00025-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2008-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1999 Dec 17;294(5):1115-25 [10600370] Mol Microbiol. 2008 Dec;70(5):1076-93 [18710431] Mol Microbiol. 2000 Aug;37(3):652-60 [10931358] Mol Microbiol. 2000 Aug;37(3):661-70 [10931359] Curr Biol. 2001 Jun 26;11(12):941-50 [11448770] J Biol Chem. 2001 Sep 21;276(38):35707-13 [11461923] Mol Microbiol. 2001 Oct;42(2):527-37 [11703673] Mol Microbiol. 2002 Jul;45(2):333-49 [12123448] J Biotechnol. 2003 Jan 9;100(1):1-12 [12413781] Res Microbiol. 2002 Oct;153(8):493-501 [12437210] J Bacteriol. 2003 Apr;185(7):2169-77 [12644486] Br J Cancer. 2003 Jul 7;89(1):192-8 [12838323] Science. 2003 Sep 12;301(5639):1496-9 [12970556] Science. 1975 Jan 24;187(4173):257-8 [1089310] J Bacteriol. 1977 Dec;132(3):784-9 [336605] J Bacteriol. 1980 Nov;144(2):833-5 [6159347] Microbiol Immunol. 1982;26(9):779-93 [6185827] Biochim Biophys Acta. 1983 Jan 20;739(1):27-34 [6187365] J Bacteriol. 1985 Jan;161(1):292-8 [2981804] Proc Natl Acad Sci U S A. 1986 May;83(10):3116-20 [3517851] Biochim Biophys Acta. 1986 Jun 20;867(3):81-8 [2424508] EMBO J. 1986 Aug;5(8):2023-9 [3019679] Gene. 1988 Jun 30;66(2):259-68 [3049248] Mol Microbiol. 1990 Nov;4(11):1807-18 [1707122] New Biol. 1990 Nov;2(11):946-56 [2101633] Mol Microbiol. 1991 Jul;5(7):1627-37 [1943700] J Mol Biol. 1992 Jan 5;223(1):41-54 [1370544] Mol Microbiol. 1991 Aug;5(8):1961-73 [1722558] Mol Microbiol. 1992 Apr;6(7):895-905 [1602968] J Mol Biol. 1992 Aug 5;226(3):637-49 [1380562] Biotechnol Prog. 1994 Nov-Dec;10(6):621-9 [7765697] Plasmid. 1994 Sep;32(2):168-81 [7531349] J Bacteriol. 1996 Apr;178(7):2044-50 [8606182] Mol Microbiol. 1996 Apr;20(1):53-63 [8861204] Mol Microbiol. 1996 Sep;21(5):1049-60 [8885274] Appl Environ Microbiol. 1997 May;63(5):1917-24 [9143123] J Mol Biol. 1997 Oct 17;273(1):38-51 [9367744] Mol Microbiol. 1999 Jun;32(5):1090-102 [10361310] Curr Biol. 2004 Dec 29;14(24):2271-6 [15620655] Nucleic Acids Res. 2005;33(3):1040-50 [15718303] Nat Rev Microbiol. 2005 May;3(5):371-82 [15864262] J Bacteriol. 2005 Oct;187(19):6641-50 [16166525] Trends Biochem Sci. 2005 Dec;30(12):672-9 [16257530] J Bacteriol. 2006 Aug;188(15):5374-84 [16855226] Biochem J. 2006 Oct 1;399(1):1-7 [16956326] Nucleic Acids Res. 2006;34(20):5915-22 [17065468] Curr Opin Microbiol. 2007 Apr;10(2):117-24 [17376733] Curr Opin Microbiol. 2007 Apr;10(2):96-101 [17383222] Curr Opin Microbiol. 2007 Apr;10(2):134-9 [17383928] Curr Opin Microbiol. 2007 Apr;10(2):125-33 [17395525] Mol Microbiol. 2007 May;64(3):738-54 [17462020] Mol Cell. 2007 May 11;26(3):381-92 [17499044] Curr Opin Microbiol. 2007 Jun;10(3):257-61 [17553733] J Mol Microbiol Biotechnol. 2007;13(4):200-9 [17827970] Mol Microbiol. 2008 Oct;70(1):258-70 [18761622] Res Microbiol. 1999 Nov-Dec;150(9-10):653-64 [10673004] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MMBR.00025-08 ER - TY - JOUR T1 - Constitutive expression of human keratin 14 gene in mouse lung induces premalignant lesions and squamous differentiation. AN - 69863815; 18701433 AB - Squamous cell carcinoma accounts for 20% of all human lung cancers and is strongly linked to cigarette smoking. It develops through premalignant changes that are characterized by high levels of keratin 14 (K14) expression in the airway epithelium and evolve through basal cell hyperplasia, squamous metaplasia and dysplasia to carcinoma in situ and invasive carcinoma. In order to explore the impact of K14 in the pulmonary epithelium that normally lacks both squamous differentiation and K14 expression, human keratin 14 gene hK14 was constitutively expressed in mouse airway progenitor cells using a mouse Clara cell specific 10 kDa protein (CC10) promoter. While the lungs of CC10-hK14 transgenic mice developed normally, we detected increased expression of K14 and the molecular markers of squamous differentiation program such as involucrin, loricrin, small proline-rich protein 1A, transglutaminase 1 and cholesterol sulfotransferase 2B1. In contrast, wild-type lungs were negative. Aging CC10-hK14 mice revealed multifocal airway cell hyperplasia, occasional squamous metaplasia and their lung tumors displayed evidence for multidirectional differentiation. We conclude that constitutive expression of hK14 initiates squamous differentiation program in the mouse lung, but fails to promote squamous maturation. Our study provides a novel model for assessing the mechanisms of premalignant lesions in vivo by modifying differentiation and proliferation of airway progenitor cells. JF - Carcinogenesis AU - Dakir, E L Habib AU - Feigenbaum, Lionel AU - Linnoila, R Ilona AD - Experimental Pathology Section, Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2377 EP - 2384 VL - 29 IS - 12 KW - KRT14 protein, human KW - 0 KW - Keratin-14 KW - Index Medicus KW - Animals KW - Blotting, Western KW - Transfection KW - Humans KW - Immunoprecipitation KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Transgenic KW - Immunohistochemistry KW - Keratin-14 -- genetics KW - Cell Transformation, Neoplastic -- metabolism KW - Carcinoma, Squamous Cell -- metabolism KW - Precancerous Conditions -- metabolism KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- genetics KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- genetics KW - Lung Neoplasms -- genetics KW - Cell Transformation, Neoplastic -- genetics KW - Keratin-14 -- metabolism KW - Lung Neoplasms -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69863815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Constitutive+expression+of+human+keratin+14+gene+in+mouse+lung+induces+premalignant+lesions+and+squamous+differentiation.&rft.au=Dakir%2C+E+L+Habib%3BFeigenbaum%2C+Lionel%3BLinnoila%2C+R+Ilona&rft.aulast=Dakir&rft.aufirst=E+L&rft.date=2008-12-01&rft.volume=29&rft.issue=12&rft.spage=2377&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgn190 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-28 N1 - Date created - 2008-12-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Cell Biol. 1990 Dec;2(6):1028-35 [1712211] Cancer Res. 1990 Jan 1;50(1):120-8 [1967140] Virchows Arch B Cell Pathol Incl Mol Pathol. 1992;61(6):375-87 [1349777] J Natl Cancer Inst Monogr. 1992;(13):93-100 [1327037] Biochem Biophys Res Commun. 1993 Nov 30;197(1):163-71 [7916613] J Biol Chem. 1995 Feb 10;270(6):2689-94 [7852338] Cell Growth Differ. 1997 Feb;8(2):145-55 [9040936] J Cell Biol. 1998 Oct 19;143(2):487-99 [9786957] Gene. 1998 Dec 11;224(1-2):59-66 [9931436] Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L625-32 [15579627] Nat Rev Mol Cell Biol. 2005 Apr;6(4):328-40 [15803139] Am J Respir Cell Mol Biol. 2005 Nov;33(5):455-62 [16055670] Curr Mol Med. 2007 Feb;7(1):3-14 [17311529] J Pharmacol Exp Ther. 2007 Aug;322(2):529-40 [17496163] Nature. 2007 Aug 16;448(7155):807-10 [17676035] Annu Rev Pathol. 2006;1:331-48 [18039118] J Invest Dermatol. 2008 Jun;128(6):1517-24 [18049449] J Cell Biol. 2000 Apr 3;149(1):17-22 [10747083] Cancer Res. 2000 Aug 1;60(15):4005-9 [10945598] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13031-6 [11698679] Methods. 2001 Dec;25(4):402-8 [11846609] Transgenic Res. 2002 Feb;11(1):21-9 [11874100] Respir Res. 2002;3:20 [11980589] Histopathology. 2002 May;40(5):403-39 [12010363] Pathol Int. 2002 Apr;52(4):286-93 [12031084] Bioessays. 2002 Sep;24(9):789-800 [12210515] Am J Pathol. 2004 Feb;164(2):577-88 [14742263] Cancer Res. 2004 Mar 1;64(5):1647-54 [14996723] J Invest Dermatol. 2004 May;122(5):1207-13 [15140224] J Mol Biol. 1975 Nov 5;98(3):503-17 [1195397] Lab Invest. 1978 Jun;38(6):648-53 [661220] J Anat. 1981 Jan;132(Pt 1):71-84 [7275793] Cell. 1982 Nov;31(1):11-24 [6186379] Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;45(2):221-40 [6143448] Proc Natl Acad Sci U S A. 1984 Apr;81(7):1991-5 [6326095] Anal Biochem. 1984 Feb;137(1):266-7 [6329026] J Immunol. 1985 Oct;135(4):2589-92 [4031496] EMBO J. 1986 Jul;5(7):1567-75 [3017704] Cell. 1987 Feb 13;48(3):453-63 [2433047] Lab Invest. 1987 Aug;57(2):219-29 [3613528] J Invest Dermatol. 1989 Feb;92(2):203-9 [2465352] Mol Cell Biol. 1989 Sep;9(9):3685-97 [2476664] Am J Clin Pathol. 1992 Feb;97(2):233-43 [1372146] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgn190 ER - TY - JOUR T1 - Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. AN - 69852194; 19047179 AB - Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here, we describe the involvement of BRCA2 in O6-alkylguanine DNA alkyltransferase (AGT)-mediated repair of O6-methylguanine adducts. We show that BRCA2 physically associates and undergoes repair-mediated degradation with AGT. In contrast, BRCA2 with a 29-amino-acid deletion in an evolutionarily conserved domain does not bind to alkylated AGT; the two proteins are not degraded; and mouse embryonic fibroblasts are specifically sensitive to alkylating agents that result in O6-methylguanine adducts. We show that O6-benzylguanine (O6BG), a nontoxic inhibitor of AGT, can also induce BRCA2 degradation. BRCA2 is a viable target for cancer therapy because BRCA2-deficient cells are hypersensitive to chemotherapeutic DNA-damaging agents. We show a marked effect of O6BG pretreatment on cell sensitivity to cisplatin. We also show the efficacy of this approach on a wide range of human tumor cell lines, which suggests that chemosensitization of tumors by targeted degradation of BRCA2 may be an important consideration when devising cancer therapeutics. JF - Cancer research AU - Philip, Subha AU - Swaminathan, Srividya AU - Kuznetsov, Sergey G AU - Kanugula, Sreenivas AU - Biswas, Kajal AU - Chang, Suhwan AU - Loktionova, Natalia A AU - Haines, Diana C AU - Kaldis, Philipp AU - Pegg, Anthony E AU - Sharan, Shyam K AD - Mouse Cancer Genetics Program, Center for Cancer Research, and Pathology Histotechnology Laboratory, Science Applications International Corporation-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 9973 EP - 9981 VL - 68 IS - 23 KW - Alkylating Agents KW - 0 KW - BRCA2 Protein KW - BRCA2 protein, mouse KW - O(6)-benzylguanine KW - 01KC87F8FE KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - Guanine KW - 5Z93L87A1R KW - O-(6)-methylguanine KW - 9B710FV2AE KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Index Medicus KW - Animals KW - Humans KW - Molecular Sequence Data KW - Mice KW - Guanine -- analogs & derivatives KW - Amino Acid Sequence KW - Mice, Transgenic KW - Guanine -- pharmacology KW - Guanine -- metabolism KW - Mice, Knockout KW - Gene Deletion KW - DNA Repair -- physiology KW - O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors KW - O(6)-Methylguanine-DNA Methyltransferase -- metabolism KW - BRCA2 Protein -- metabolism KW - BRCA2 Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69852194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Degradation+of+BRCA2+in+alkyltransferase-mediated+DNA+repair+and+its+clinical+implications.&rft.au=Philip%2C+Subha%3BSwaminathan%2C+Srividya%3BKuznetsov%2C+Sergey+G%3BKanugula%2C+Sreenivas%3BBiswas%2C+Kajal%3BChang%2C+Suhwan%3BLoktionova%2C+Natalia+A%3BHaines%2C+Diana+C%3BKaldis%2C+Philipp%3BPegg%2C+Anthony+E%3BSharan%2C+Shyam+K&rft.aulast=Philip&rft.aufirst=Subha&rft.date=2008-12-01&rft.volume=68&rft.issue=23&rft.spage=9973&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1179 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Mol Mutagen. 2001;38(2-3):235-43 [11746760] Clin Cancer Res. 2007 May 1;13(9):2728-37 [17473206] Cancer Res. 2002 Feb 15;62(4):990-4 [11861370] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13920-5 [10570174] Mutat Res. 2000 Apr;462(2-3):83-100 [10767620] Genesis. 2001 Jan;29(1):14-21 [11135458] Oncogene. 2001 Jul 5;20(30):3937-48 [11494122] Bioessays. 2002 Mar;24(3):255-66 [11891762] J Clin Oncol. 2002 May 1;20(9):2388-99 [11981013] Science. 2002 Jul 26;297(5581):606-9 [12065746] Genes Chromosomes Cancer. 2003 Apr;36(4):317-31 [12619154] Mol Cancer Ther. 2003 Jul;2(7):633-40 [12883036] Nat Rev Cancer. 2004 Apr;4(4):296-307 [15057289] J Biol Chem. 1982 Nov 25;257(22):13776-80 [6754717] Proc Natl Acad Sci U S A. 1990 Jul;87(14):5368-72 [2164681] Carcinogenesis. 1991 Sep;12(9):1679-83 [1893528] J Med Chem. 1992 Nov 13;35(23):4486-91 [1447749] Prog Nucleic Acid Res Mol Biol. 1995;51:167-223 [7659775] Biochemistry. 1996 Jan 30;35(4):1328-34 [8573590] Carcinogenesis. 1996 Jun;17(6):1215-20 [8681434] Nature. 1997 Apr 24;386(6627):804-10 [9126738] Genes Dev. 1997 May 15;11(10):1226-41 [9171368] Genes Dev. 1997 May 15;11(10):1242-52 [9171369] Cancer Res. 1997 Jun 15;57(12):2415-8 [9192819] Nat Genet. 1997 Dec;17(4):423-30 [9398843] J Biol Chem. 1997 Dec 19;272(51):31941-4 [9405383] Cancer Res. 1998 Apr 1;58(7):1338-43 [9537225] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5287-92 [9560268] Mol Cell. 1998 Feb;1(3):347-57 [9660919] J Natl Cancer Inst. 1998 Jul 1;90(13):978-85 [9665145] Hum Genet. 1998 Aug;103(2):154-61 [9760198] Annu Rev Genet. 1998;32:95-121 [9928476] Mutagenesis. 1999 May;14(3):339-47 [10375003] J Pharmacol Exp Ther. 2005 Jan;312(1):206-13 [15304523] Clin Exp Metastasis. 2004;21(6):543-52 [15679052] Cancer Chemother Pharmacol. 2005 Apr;55(4):333-42 [15723259] Nature. 2005 Apr 14;434(7035):913-7 [15829966] Nature. 2005 Apr 14;434(7035):917-21 [15829967] Genes Chromosomes Cancer. 2005 Dec;44(4):429-37 [16127665] Cancer Res. 2005 Nov 15;65(22):10145-8 [16287996] Cancer Treat Rev. 2006 Jun;32(4):261-76 [16698182] Int J Biol Sci. 2006;2(4):179-85 [16810332] Curr Opin Pharmacol. 2006 Aug;6(4):355-63 [16777483] Oncogene. 2006 Sep 25;25(43):5885-97 [16998503] Cancer Treat Rev. 2007 Feb;33(1):9-23 [17084534] Cell. 2002 Jan 25;108(2):171-82 [11832208] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1179 ER - TY - JOUR T1 - Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. AN - 69848358; 18773491 AB - Nodal signaling is a critical regulator of multiple aspects of early vertebrate development including asymmetry along the left/right (LR) axis. To study Nodal function occurring specifically in the postgastrulation embryo, we have used Cre/loxP based conditional mutagenesis. A floxed allele of Nodal was generated and shown to have wild-type function. This allele was then used in conjunction with the T-Cre line, which expresses Cre recombinase broadly in the mesodermal and definitive endodermal lineages posterior to the cranial region. T-Cre activity leads to complete deletion of Nodal before its normal transient expression in the early somite stage lateral plate mesoderm, thereby causing severe LR developmental defects. No other abnormalities were found, suggesting that Nodal signaling has no additional essential functions in developmental patterning within the extensive mesodermal and endodermal domains marked by T-Cre activity. JF - Developmental dynamics : an official publication of the American Association of Anatomists AU - Kumar, Amit AU - Lualdi, Margaret AU - Lewandoski, Mark AU - Kuehn, Michael R AD - Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3591 EP - 3601 VL - 237 IS - 12 SN - 1058-8388, 1058-8388 KW - Nodal Protein KW - 0 KW - Cre recombinase KW - EC 2.7.7.- KW - Integrases KW - Index Medicus KW - Body Patterning KW - Animals KW - Integrases -- genetics KW - Mice KW - Mice, Transgenic KW - Embryo, Mammalian -- metabolism KW - Gene Deletion KW - Phenotype KW - Alleles KW - Base Sequence KW - Genes, Reporter -- genetics KW - Integrases -- metabolism KW - Embryo, Mammalian -- embryology KW - Mutation -- genetics KW - Gene Expression Regulation, Developmental KW - Mesoderm -- embryology KW - Nodal Protein -- genetics KW - Endoderm -- embryology KW - Gastrointestinal Tract -- metabolism KW - Gastrointestinal Tract -- embryology KW - Endoderm -- metabolism KW - Mesoderm -- metabolism KW - Nodal Protein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69848358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+dynamics+%3A+an+official+publication+of+the+American+Association+of+Anatomists&rft.atitle=Broad+mesodermal+and+endodermal+deletion+of+Nodal+at+postgastrulation+stages+results+solely+in+left%2Fright+axial+defects.&rft.au=Kumar%2C+Amit%3BLualdi%2C+Margaret%3BLewandoski%2C+Mark%3BKuehn%2C+Michael+R&rft.aulast=Kumar&rft.aufirst=Amit&rft.date=2008-12-01&rft.volume=237&rft.issue=12&rft.spage=3591&rft.isbn=&rft.btitle=&rft.title=Developmental+dynamics+%3A+an+official+publication+of+the+American+Association+of+Anatomists&rft.issn=10588388&rft_id=info:doi/10.1002%2Fdvdy.21665 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genesis. 2000 Feb;26(2):118-20 [10686603] Genesis. 2007 Dec;45(12):729-36 [18064671] Development. 2001 May;128(10):1831-43 [11311163] Nat Rev Genet. 2001 Oct;2(10):743-55 [11584291] Genes Dev. 2002 Sep 15;16(18):2339-44 [12231623] Dev Biol. 2003 Apr 1;256(1):160-72 [12654299] BMC Dev Biol. 2001;1:4 [11299042] Dev Cell. 2004 Jan;6(1):7-28 [14723844] Semin Cell Dev Biol. 2004 Oct;15(5):543-54 [15271300] Semin Cell Dev Biol. 2004 Oct;15(5):555-61 [15271301] Dev Biol. 2004 Sep 1;273(1):149-59 [15302604] Mol Cell Biol. 2004 Nov;24(21):9383-9 [15485907] Dev Dyn. 1992 Jul;194(3):198-208 [1467556] Nature. 1993 Feb 11;361(6412):543-7 [8429908] Development. 1994 Jul;120(7):1919-28 [7924997] Nature. 1996 May 9;381(6578):158-61 [8610013] Genes Dev. 1997 Jul 15;11(14):1812-26 [9242489] Nat Genet. 1998 Feb;18(2):136-41 [9462741] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3667-72 [9520423] Nat Genet. 1999 Jan;21(1):70-1 [9916792] Mech Dev. 2005 Jan;122(1):3-25 [15582774] Development. 2005 Sep;132(17):3859-71 [16049111] Cell. 2006 Apr 7;125(1):33-45 [16615888] Dev Biol. 2006 May 15;293(2):370-81 [16564040] Cell. 2006 Oct 6;127(1):27-32 [17018270] Differentiation. 2007 Feb;75(2):133-46 [17316383] Development. 2007 Mar;134(6):1023-34 [17287255] Methods Mol Biol. 2000;137:125-37 [10948531] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/dvdy.21665 ER - TY - JOUR T1 - Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. AN - 69847827; 19047460 AB - Cellular responses to both physiological and pathological DNA double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (ATM) kinase. Upon DNA damage, an activation mechanism involving autophosphorylation has been reported to allow ATM to phosphorylate downstream targets important for cell cycle checkpoints and DNA repair. In humans, serine residues 367, 1893, and 1981 have been shown to be autophosphorylation sites that are individually required for ATM activation. To test the physiological importance of these sites, we generated a transgenic mouse model in which all three conserved ATM serine autophosphorylation sites (S367/1899/1987) have been replaced with alanine. In this study, we show that ATM-dependent responses at both cellular and organismal levels are functional in mice that express a triple serine mutant form of ATM as their sole ATM species. These results lend further support to the notion that ATM autophosphorylation correlates with the DNA damage-induced activation of the kinase but is not required for ATM function in vivo. JF - The Journal of cell biology AU - Daniel, Jeremy A AU - Pellegrini, Manuela AU - Lee, Ji-Hoon AU - Paull, Tanya T AU - Feigenbaum, Lionel AU - Nussenzweig, André AD - Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 777 EP - 783 VL - 183 IS - 5 KW - Cell Cycle Proteins KW - 0 KW - DNA-Binding Proteins KW - Tumor Suppressor Proteins KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Atm protein, mouse KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Animals KW - Enzyme Activation KW - Genes, cdc KW - Mice KW - Amino Acid Sequence KW - Dose-Response Relationship, Radiation KW - Mice, Transgenic KW - Intestine, Small -- radiation effects KW - Phosphorylation KW - Genomic Instability KW - Cells, Cultured KW - Recombination, Genetic KW - Molecular Sequence Data KW - Lymphocytes -- enzymology KW - Testis -- enzymology KW - Mutation KW - Male KW - Intestine, Small -- enzymology KW - Cell Nucleus -- enzymology KW - Protein-Serine-Threonine Kinases -- metabolism KW - Cell Cycle Proteins -- genetics KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - DNA-Binding Proteins -- genetics KW - Protein-Serine-Threonine Kinases -- genetics KW - DNA Breaks, Double-Stranded KW - Cell Nucleus -- radiation effects KW - DNA-Binding Proteins -- metabolism KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69847827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Multiple+autophosphorylation+sites+are+dispensable+for+murine+ATM+activation+in+vivo.&rft.au=Daniel%2C+Jeremy+A%3BPellegrini%2C+Manuela%3BLee%2C+Ji-Hoon%3BPaull%2C+Tanya+T%3BFeigenbaum%2C+Lionel%3BNussenzweig%2C+Andr%C3%A9&rft.aulast=Daniel&rft.aufirst=Jeremy&rft.date=2008-12-01&rft.volume=183&rft.issue=5&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=1540-8140&rft_id=info:doi/10.1083%2Fjcb.200805154 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2002 Jun 20;21(27):4191-9 [12082606] Genes Dev. 2002 Mar 1;16(5):571-82 [11877377] Nature. 2003 Jan 30;421(6922):499-506 [12556884] Nat Rev Cancer. 2003 Mar;3(3):155-68 [12612651] Nucleic Acids Res. 2003 Aug 1;31(15):e80 [12888532] EMBO J. 2003 Oct 15;22(20):5612-21 [14532133] EMBO J. 2003 Dec 15;22(24):6610-20 [14657032] Science. 2004 Apr 2;304(5667):93-6 [15064416] Cell. 1996 Jul 12;86(1):159-71 [8689683] Genes Dev. 1996 Oct 1;10(19):2411-22 [8843194] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13084-9 [8917548] Science. 1998 Sep 11;281(5383):1674-7 [9733514] Science. 1998 Sep 11;281(5383):1677-9 [9733515] Science. 1998 Dec 4;282(5395):1893-7 [9836640] Adv Immunol. 1999;72:179-89 [10361575] Oncogene. 1999 Jul 15;18(28):4047-54 [10435585] J Exp Med. 2004 Nov 1;200(9):1111-21 [15504820] J Exp Med. 2004 Nov 1;200(9):1103-10 [15520243] Science. 2005 Apr 22;308(5721):551-4 [15790808] Mol Cell Biol. 2005 Jul;25(13):5363-79 [15964794] Nat Cell Biol. 2005 Jul;7(7):675-85 [15965469] J Clin Pathol. 2005 Oct;58(10):1009-15 [16189143] Immunol Rev. 2006 Feb;209:142-58 [16448540] Mol Cell Biol. 2006 Mar;26(5):1691-9 [16478990] Nat Struct Mol Biol. 2006 May;13(5):451-7 [16622404] Nature. 2006 Jul 27;442(7101):466-70 [16799570] Nat Cell Biol. 2006 Aug;8(8):870-6 [16862143] EMBO J. 2006 Aug 9;25(15):3504-14 [16858402] Nature. 2006 Sep 14;443(7108):222-5 [16906133] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6323-8 [17405860] Science. 2007 May 25;316(5828):1160-6 [17525332] Nat Cell Biol. 2007 Jun;9(6):683-90 [17486112] J Exp Med. 2007 Jun 11;204(6):1371-81 [17502661] Cell. 2007 Jul 13;130(1):63-75 [17599403] Annu Rev Genomics Hum Genet. 2007;8:37-55 [17887919] Nat Cell Biol. 2007 Nov;9(11):1311-8 [17952060] Mol Cell Biol. 2007 Dec;27(24):8502-9 [17923702] Oncogene. 2007 Dec 10;26(56):7741-8 [18066086] Oncogene. 2007 Dec 10;26(56):7759-64 [18066088] Annu Rev Immunol. 2008;26:261-92 [18370922] J Biol Chem. 2001 Oct 12;276(41):38224-30 [11454856] Genes Dev. 2002 Mar 1;16(5):560-70 [11877376] Nat Cell Biol. 2002 Dec;4(12):993-7 [12447390] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1083/jcb.200805154 ER - TY - JOUR T1 - SMAD6 contributes to patient survival in non-small cell lung cancer and its knockdown reestablishes TGF-beta homeostasis in lung cancer cells. AN - 69846388; 19047146 AB - The malignant transformation in several types of cancer, including lung cancer, results in a loss of growth inhibition by transforming growth factor-beta (TGF-beta). Here, we show that SMAD6 expression is associated with a reduced survival in lung cancer patients. Short hairpin RNA (shRNA)-mediated knockdown of SMAD6 in lung cancer cell lines resulted in reduced cell viability and increased apoptosis as well as inhibition of cell cycle progression. However, these results were not seen in Beas2B, a normal bronchial epithelial cell line. To better understand the mechanism underlying the association of SMAD6 with poor patient survival, we used a lentivirus construct carrying shRNA for SMAD6 to knock down expression of the targeted gene. Through gene expression analysis, we observed that knockdown of SMAD6 led to the activation of TGF-beta signaling through up-regulation of plasminogen activator inhibitor-1 and phosphorylation of SMAD2/3. Furthermore, SMAD6 knockdown activated the c-Jun NH2-terminal kinase pathway and reduced phosphorylation of Rb-1, resulting in increased G0-G1 cell arrest and apoptosis in the lung cancer cell line H1299. These results jointly suggest that SMAD6 plays a critical role in supporting lung cancer cell growth and survival. Targeted inactivation of SMAD6 may provide a novel therapeutic strategy for lung cancers expressing this gene. JF - Cancer research AU - Jeon, Hyo-Sung AU - Dracheva, Tatiana AU - Yang, Sei-Hoon AU - Meerzaman, Daoud AU - Fukuoka, Junya AU - Shakoori, Abbas AU - Shilo, Konstantin AU - Travis, William D AU - Jen, Jin AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 9686 EP - 9692 VL - 68 IS - 23 KW - RNA, Small Interfering KW - 0 KW - SMAD6 protein, human KW - Smad6 Protein KW - Transforming Growth Factor beta KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Phosphorylation KW - Down-Regulation KW - Cell Growth Processes -- physiology KW - Humans KW - Cell Cycle -- physiology KW - Apoptosis -- physiology KW - Transduction, Genetic KW - RNA, Small Interfering -- genetics KW - Cell Line, Tumor KW - Immunohistochemistry KW - Signal Transduction KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Smad6 Protein -- genetics KW - Smad6 Protein -- biosynthesis KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- genetics KW - Transforming Growth Factor beta -- metabolism KW - Smad6 Protein -- deficiency KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69846388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=SMAD6+contributes+to+patient+survival+in+non-small+cell+lung+cancer+and+its+knockdown+reestablishes+TGF-beta+homeostasis+in+lung+cancer+cells.&rft.au=Jeon%2C+Hyo-Sung%3BDracheva%2C+Tatiana%3BYang%2C+Sei-Hoon%3BMeerzaman%2C+Daoud%3BFukuoka%2C+Junya%3BShakoori%2C+Abbas%3BShilo%2C+Konstantin%3BTravis%2C+William+D%3BJen%2C+Jin&rft.aulast=Jeon&rft.aufirst=Hyo-Sung&rft.date=2008-12-01&rft.volume=68&rft.issue=23&rft.spage=9686&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1083 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-16 N1 - Date created - 2008-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Genomics. 2007;8:98 [17425807] Cancer Res. 2007 Mar 1;67(5):2317-24 [17332363] N Engl J Med. 2000 May 4;342(18):1350-8 [10793168] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4820-5 [10781087] Nat Cell Biol. 2000 Apr;2(4):E65-7 [10783254] J Natl Cancer Inst. 2000 Sep 6;92(17):1388-402 [10974075] Cell. 2000 Oct 13;103(2):239-52 [11057897] J Cell Physiol. 2001 Jun;187(3):265-76 [11319750] Trends Cell Biol. 2001 Nov;11(11):S44-51 [11684442] J Cell Biol. 2001 Dec 10;155(6):1017-27 [11739411] Nature. 2002 Aug 8;418(6898):641-6 [12167862] Cancer Res. 2003 Nov 15;63(22):7760-8 [14633701] Mol Cell Biol. 2003 Dec;23(24):9081-93 [14645520] Clin Cancer Res. 2004 Jul 1;10(13):4314-24 [15240517] Cancer Biol Ther. 2004 Jul;3(7):667-75 [15197354] Proc Natl Acad Sci U S A. 1986 Apr;83(8):2438-42 [2871553] EMBO J. 1987 May;6(5):1281-6 [3111844] Science. 1988 Apr 8;240(4849):196-9 [2895499] Cancer Res. 1988 Jul 15;48(14):3898-904 [3164252] Cancer Res. 1996 Nov 1;56(21):4831-5 [8895728] J Biol Chem. 1997 Jan 17;272(3):1429-32 [8999807] Lung Cancer. 1996 Dec;16(1):47-59 [9017584] Cell. 1997 Jun 27;89(7):1165-73 [9215638] Nature. 1997 Oct 9;389(6651):622-6 [9335505] Nature. 1997 Oct 9;389(6651):631-5 [9335507] Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10669-74 [9380693] Nature. 1997 Dec 4;390(6659):465-71 [9393997] Genes Dev. 1998 Jan 15;12(2):186-97 [9436979] EMBO J. 1998 Jun 1;17(11):3091-100 [9606191] Annu Rev Biochem. 1998;67:753-91 [9759503] Oncogene. 1998 Oct 1;17(13):1743-7 [9796704] Oncogene. 1999 May 20;18(20):3098-103 [10340381] Oncogene. 1999 Sep 23;18(39):5363-72 [10498890] Anticancer Res. 2004 Nov-Dec;24(6):3703-9 [15736400] J Natl Cancer Inst. 2005 Dec 7;97(23):1734-46 [16333029] J Biol Chem. 2006 Jul 21;281(29):20357-67 [16687405] Nat Immunol. 2006 Oct;7(10):1057-65 [16951688] Oncogene. 1999 Dec 2;18(51):7280-6 [10602482] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1083 ER - TY - JOUR T1 - Risk of radiation-related salivary gland carcinomas among survivors of Hodgkin lymphoma: a population-based analysis. AN - 69840096; 18823043 AB - Radiotherapy for Hodgkin lymphoma (HL) increases the risk of salivary gland carcinomas (SGC). To the authors' knowledge, however, the magnitude of the risk has not been assessed to date. The risks of SGC among 20,928 1-year survivors of HL who were diagnosed between 1973 and 2003 were evaluated in 11 population-based cancer registry areas of the Surveillance, Epidemiology, and End Results (SEER) program. Observed-to-expected ratios (O/E) were assessed by radiation treatment, sex, age at the time of HL diagnosis, calendar year of diagnosis, attained age, time since HL diagnosis, histologic type of SGC, and site of occurrence in the major salivary glands. Among 11,047 HL patients who received radiotherapy as part of their initial treatment for HL, 21 developed subsequent invasive SGC (O/E = 16.9; 95% confidence interval [95% CI], 10.4-25.8). The risk of radiation-related SGC was highest for younger HL patients (age <20 years) (O/E = 45.5; 95% CI, 12.4-116.5) and among 10-year survivors (O/E = 23.9; 95% CI, 13.1-40.1), with risks remaining elevated for at least 2 decades after irradiation. Significant differences in risk by histologic type were observed, with a particularly high risk of developing mucoepidermoid carcinomas (O = 14; O/E = 44.2 [95% CI, 24.2-74.2]) and adenocarcinomas (O = 4; O/E = 30.6 [95% CI, 8.3-78.2]) noted. HL patients treated with radiotherapy experienced a significantly increased risk of SGC, particularly when exposed at young ages or for at least 2 decades after exposure. Although the results of the current study reflect the late effects of former HL treatment approaches, they point to the importance of long-term follow-up and a heightened awareness of SGC risk in this population. (c) 2008 American Cancer Society JF - Cancer AU - Boukheris, Houda AU - Ron, Elaine AU - Dores, Graça M AU - Stovall, Marilyn AU - Smith, Susan A AU - Curtis, Rochelle E AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. boukherh@mail.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 3153 EP - 3159 VL - 113 IS - 11 SN - 0008-543X, 0008-543X KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Age Factors KW - Humans KW - SEER Program KW - Adult KW - Male KW - Female KW - Risk Assessment KW - Hodgkin Disease -- radiotherapy KW - Hodgkin Disease -- pathology KW - Salivary Gland Neoplasms -- etiology KW - Neoplasms, Second Primary -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69840096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Risk+of+radiation-related+salivary+gland+carcinomas+among+survivors+of+Hodgkin+lymphoma%3A+a+population-based+analysis.&rft.au=Boukheris%2C+Houda%3BRon%2C+Elaine%3BDores%2C+Gra%C3%A7a+M%3BStovall%2C+Marilyn%3BSmith%2C+Susan+A%3BCurtis%2C+Rochelle+E&rft.aulast=Boukheris&rft.aufirst=Houda&rft.date=2008-12-01&rft.volume=113&rft.issue=11&rft.spage=3153&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.23918 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-13 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Surg. 1978 Jun;135(6):820-4 [149506] Am J Surg. 1968 Oct;116(4):518-23 [4300240] Int J Epidemiol. 1984 Mar;13(1):112-5 [6698695] Am J Surg. 1984 Mar;147(3):345-8 [6703206] Cancer. 1984 Nov 1;54(9):1854-9 [6478421] Int J Cancer. 1987 May 15;39(5):571-85 [3570550] J Am Dent Assoc. 1990 Feb;120(2):151-8 [2405031] Ann Oncol. 1992 Sep;3 Suppl 4:117-28 [1450072] Blood. 1994 Jan 15;83(2):318-29 [8286731] Radiat Res. 1996 Jul;146(1):28-36 [8677295] N Engl J Med. 1997 Mar 27;336(13):897-904 [9070469] Cancer. 1997 Apr 15;79(8):1465-75 [9118025] J Clin Oncol. 1998 Feb;16(2):536-44 [9469338] Radiat Res. 1998 Jun;149(6):625-30 [9611101] Laryngoscope. 1998 Jul;108(7):1095-7 [9665263] Radiat Res. 2006 Jul;166(1 Pt 2):141-57 [16808603] Radiat Res. 2007 Jul;168(1):1-64 [17722996] N Engl J Med. 2007 Nov 8;357(19):1916-27 [17989384] N Engl J Med. 2007 Nov 8;357(19):1968-71 [17989391] J Clin Oncol. 2000 Jun;18(12):2435-43 [10856104] Br J Haematol. 2000 Sep;110(3):504-11 [10997959] J Clin Oncol. 2001 Nov 15;19(22):4238-44 [11709567] J Clin Oncol. 2002 Aug 15;20(16):3484-94 [12177110] Cancer. 2003 Aug 1;98(3):562-70 [12879474] Cancer J. 2003 Nov-Dec;9(6):467-71 [14740975] J Clin Oncol. 2004 Jul 15;22(14):2835-41 [15199092] Cancer. 1983 Jun 15;51(12):2159-63 [6850504] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.23918 ER - TY - JOUR T1 - Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures. AN - 69839991; 18845770 AB - Meconium analysis is a diagnostically sensitive and objective alternative to maternal self-report for detecting prenatal tobacco exposure. Nicotine and metabolite disposition in meconium is poorly characterized, and correlation of analytes' concentrations with neonatal outcomes is unexplored. Our objectives were to quantify nicotine, cotinine, trans-3'-hydroxycotinine (OH-cotinine), nornicotine, norcotinine, and glucuronide concentrations in meconium, identify the best biomarkers of in utero tobacco exposure, compare meconium concentrations of tobacco-exposed and nonexposed neonates, and investigate concentration-outcome relationships. We quantified concentrations of nicotine and 4 metabolites with and without hydrolysis simultaneously in meconium from tobacco-exposed and nonexposed neonates by liquid chromatography-tandem mass spectrometry. We compared meconium concentrations to birth weight, length, head circumference, gestational age, and 1- and 5-min Apgar scores. Nicotine, cotinine, and OH-cotinine were the most prevalent and abundant meconium tobacco biomarkers and were found in higher concentrations in tobacco-exposed neonates. Whereas cotinine and OH-cotinine are glucuronide bound, performing the lengthy and costly enzymatic hydrolysis identified only 1 additional positive specimen. Unconjugated nicotine, cotinine, or OH-cotinine meconium concentration >10 ng/g most accurately discriminated active from passive and nonexposed neonates. There was no significant correlation between quantitative nicotine and metabolite meconium results and neonatal outcomes, although presence of a nicotine biomarker predicted decreased head circumference. Unconjugated nicotine, cotinine, and OH-cotinine should be analyzed in meconium to detect in utero tobacco exposure, as approximately 25% of positive specimens did not contain cotinine. Immunoassay testing monitoring cotinine only would underestimate the prevalence of prenatal tobacco exposure. JF - Clinical chemistry AU - Gray, Teresa R AU - Magri, Raquel AU - Shakleya, Diaa M AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Baltimore, MD 21224, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2018 EP - 2027 VL - 54 IS - 12 KW - Biomarkers KW - 0 KW - Glucuronates KW - Tobacco Smoke Pollution KW - nicotine N-glucuronide KW - 152306-59-7 KW - norcotinine KW - 17114-40-8 KW - hydroxycotinine KW - 27323-64-4 KW - Nicotine KW - 6M3C89ZY6R KW - nornicotine KW - 83H6L5QD8Z KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Cotinine -- analysis KW - Glucuronates -- analysis KW - Humans KW - Gestational Age KW - Infant, Newborn KW - Tandem Mass Spectrometry KW - Hydrolysis KW - Pregnancy KW - Apgar Score KW - Biomarkers -- analysis KW - Chromatography, Liquid KW - Cotinine -- analogs & derivatives KW - Female KW - Body Size KW - Maternal Exposure -- adverse effects KW - Maternal-Fetal Exchange KW - Nicotine -- metabolism KW - Meconium -- chemistry KW - Nicotine -- analysis KW - Nicotine -- adverse effects KW - Tobacco Smoke Pollution -- adverse effects KW - Nicotine -- analogs & derivatives KW - Smoking -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69839991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Meconium+nicotine+and+metabolites+by+liquid+chromatography-tandem+mass+spectrometry%3A+differentiation+of+passive+and+nonexposure+and+correlation+with+neonatal+outcome+measures.&rft.au=Gray%2C+Teresa+R%3BMagri%2C+Raquel%3BShakleya%2C+Diaa+M%3BHuestis%2C+Marilyn+A&rft.aulast=Gray&rft.aufirst=Teresa&rft.date=2008-12-01&rft.volume=54&rft.issue=12&rft.spage=2018&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=1530-8561&rft_id=info:doi/10.1373%2Fclinchem.2008.109173 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-09 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Matern Child Health J. 1998 Jun;2(2):77-83 [10728263] Neonatology. 2008;94(2):75-8 [18212492] Chem Res Toxicol. 2003 Dec;16(12):1502-6 [14680362] Sao Paulo Med J. 2004 May 6;122(3):94-8 [15448806] Br J Obstet Gynaecol. 1987 Jul;94(7):678-81 [3620415] Arch Toxicol. 1988;62(5):395-7 [3242451] JAMA. 1993 Mar 24-31;269(12):1519-24 [8445814] J Pediatr. 1994 Mar;124(3):471-6 [8120724] Br J Obstet Gynaecol. 1996 Aug;103(8):806-13 [8760712] Addict Behav. 1996 Sep-Oct;21(5):675-9 [8876767] Clin Chem. 1997 Jan;43(1):180-1 [8990243] J Chromatogr B Biomed Sci Appl. 1998 Apr 10;707(1-2):317-21 [9613966] Am J Epidemiol. 1998 Aug 1;148(3):259-62 [9690362] Pharmacology. 1998 Aug;57(2):104-16 [9691230] Life Sci. 1998;63(26):2333-42 [9877223] Hum Exp Toxicol. 1999 Apr;18(4):283-90 [10333316] Forensic Sci Int. 1999 Jun 28;102(2-3):167-71 [10464932] Drug Metab Dispos. 2005 Jan;33(1):23-30 [15470160] East Mediterr Health J. 2004 Jan-Mar;10(1-2):96-105 [16201714] Paediatr Perinat Epidemiol. 2006 Mar;20(2):90-9 [16466427] Acta Obstet Gynecol Scand. 2006;85(11):1331-7 [17091413] BMC Public Health. 2007;7:81 [17506887] Hum Exp Toxicol. 2007 Jun;26(6):535-44 [17698949] Nicotine Tob Res. 2007 Oct;9(10):1005-13 [17852766] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):107-14 [18243821] Paediatr Perinat Epidemiol. 2008 Mar;22(2):162-71 [18298691] Pediatrics. 2008 Apr;121(4):e810-6 [18381510] Acta Obstet Gynecol Scand. 2002 Mar;81(3):240-4 [11966481] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1373/clinchem.2008.109173 ER - TY - JOUR T1 - Analysis of ordered categorical data: two score-independent approaches. AN - 69835239; 18266890 AB - A trend test is often employed to analyze ordered categorical data, in which a set of increasing scores is assigned a priori. There is a drawback in this approach, because how to choose a set of scores is not clear. There have been debates on which scores should be used (e.g., Graubard and Korn, 1987, Biometrics 43, 471-476; Ivanova and Berger, 2001, Biometrics 57, 567-570; Senn, 2007, Biometrics 63, 296-298). Conflicting conclusions are often obtained with different sets of scores. Two approaches, which have been applied to genetic case-control studies, are appealing for ordered categorical data, because they take into account the natural order in the data, are score independent, and not contingent on asymptotic theory. These two approaches are applied to a prospective study for detecting association between maternal drinking and congenital malformations. JF - Biometrics AU - Zheng, Gang AD - Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892-7913, USA. zhengg@nhlbi.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1276 EP - 1279 VL - 64 IS - 4 KW - Index Medicus KW - Maternal-Fetal Exchange KW - Mothers KW - Humans KW - Alcohol Drinking -- adverse effects KW - Statistics as Topic KW - Abnormalities, Multiple -- chemically induced KW - Female KW - Pregnancy KW - Biometry -- methods KW - Case-Control Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69835239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Analysis+of+ordered+categorical+data%3A+two+score-independent+approaches.&rft.au=Zheng%2C+Gang&rft.aulast=Zheng&rft.aufirst=Gang&rft.date=2008-12-01&rft.volume=64&rft.issue=4&rft.spage=1276&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=1541-0420&rft_id=info:doi/10.1111%2Fj.1541-0420.2008.00992.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1541-0420.2008.00992.x ER - TY - JOUR T1 - Treatment of high-risk chronic GVHD. AN - 69834100; 19041069 JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation AU - Pavletic, Steven AU - Vogelsand, Georgia B AD - National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1436 EP - 1437 VL - 14 IS - 12 KW - Immunosuppressive Agents KW - 0 KW - Steroids KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Tacrolimus -- adverse effects KW - Steroids -- adverse effects KW - Acute Disease KW - Transplantation Conditioning KW - Humans KW - Steroids -- administration & dosage KW - Transplantation, Homologous KW - Tacrolimus -- administration & dosage KW - Risk KW - Leukemia, Myeloid, Acute -- therapy KW - Peripheral Blood Stem Cell Transplantation KW - Drug Eruptions KW - Adult KW - Chronic Disease KW - Female KW - Male KW - Immunosuppressive Agents -- administration & dosage KW - Immunosuppressive Agents -- adverse effects KW - Graft vs Host Disease -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69834100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.atitle=Treatment+of+high-risk+chronic+GVHD.&rft.au=Pavletic%2C+Steven%3BVogelsand%2C+Georgia+B&rft.aulast=Pavletic&rft.aufirst=Steven&rft.date=2008-12-01&rft.volume=14&rft.issue=12&rft.spage=1436&rft.isbn=&rft.btitle=&rft.title=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.issn=1523-6536&rft_id=info:doi/10.1016%2Fj.bbmt.2008.05.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-10 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbmt.2008.05.016 ER - TY - JOUR T1 - Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival. AN - 69834011; 18710444 AB - To determine if the C421A single nucleotide polymorphism (SNP) in the ATP-binding cassette transporter ABCG2 increases prostate cancer risk or affects survival. Numerous studies have suggested that dietary, hormonal and environmental factors all play a role in the initiation in prostate cancer; among these, the carcinogenic heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a known substrate of the ABCG2. A SNP of ABCG2, C421A, resulting in a glutamine to lysine change at amino acid 141, has been shown to result in decreased function of the protein. Due to the expression of ABCG2 in the prostate, together with the purported role of dietary carcinogens and steroids in the development and progression of prostate cancer, 311 individuals were genotyped for the ABCG2 C421A SNP, 170 patients with androgen-independent prostate cancer (AIPC) and 141 'healthy' controls. We also evaluated the effect of this SNP on the intracellular accumulation of PhIP and testosterone in vitro. There were no significant differences in the prevalence of prostate cancer based on ABCG2 genetic variation in this population. However, survival was significantly longer for individuals with wild-type ABCG2, as compared with those hetero- or homozygous for the C421A SNP (7.4 years vs 5.3 years, P = 0.044). Intracellular accumulation of PhIP was 80% higher in HEK293 cells transfected with Q141K ABCG2 than in wild-type cells, confirming that this SNP decreases transport of PhIP. In contrast, testosterone was not transported by either wild-type or variant transfected cells, nor did it act as in inhibitor of ABCG2 in subsequent transport assays. Increased exposure to PhIP may decrease survival, but the ABCG2 C421A polymorphism does not appear to increase the risk of prostate cancer. JF - BJU international AU - Gardner, Erin R AU - Ahlers, Christoph M AU - Shukla, Suneet AU - Sissung, Tristan M AU - Ockers, Sandra B AU - Price, Douglas K AU - Hamada, Akinobu AU - Robey, Robert W AU - Steinberg, Seth M AU - Ambudkar, Suresh V AU - Dahut, William L AU - Figg, William D AD - Clinical Pharmacology Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1694 EP - 1699 VL - 102 IS - 11 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Androgens KW - Neoplasm Proteins KW - Index Medicus KW - Humans KW - Aged KW - Cell Line, Tumor KW - Polymerase Chain Reaction KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Mutation -- genetics KW - Middle Aged KW - Diet KW - Androgens -- metabolism KW - Male KW - Prostatic Neoplasms -- mortality KW - ATP-Binding Cassette Transporters -- metabolism KW - Prostatic Neoplasms -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69834011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BJU+international&rft.atitle=Association+of+the+ABCG2+C421A+polymorphism+with+prostate+cancer+risk+and+survival.&rft.au=Gardner%2C+Erin+R%3BAhlers%2C+Christoph+M%3BShukla%2C+Suneet%3BSissung%2C+Tristan+M%3BOckers%2C+Sandra+B%3BPrice%2C+Douglas+K%3BHamada%2C+Akinobu%3BRobey%2C+Robert+W%3BSteinberg%2C+Seth+M%3BAmbudkar%2C+Suresh+V%3BDahut%2C+William+L%3BFigg%2C+William+D&rft.aulast=Gardner&rft.aufirst=Erin&rft.date=2008-12-01&rft.volume=102&rft.issue=11&rft.spage=1694&rft.isbn=&rft.btitle=&rft.title=BJU+international&rft.issn=1464-410X&rft_id=info:doi/10.1111%2Fj.1464-410X.2008.07913.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-31 N1 - Date created - 2008-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2004 Sep 1;10(17):5889-94 [15355921] Clin Pharmacol Ther. 2004 Jul;76(1):38-44 [15229462] Cancer Res. 1997 Jan 15;57(2):195-8 [9000552] Pharm Res. 2004 Oct;21(10):1895-903 [15553238] Pharmacogenomics. 2005 Mar;6(2):115-38 [15882131] Cancer Chemother Pharmacol. 2005 Aug;56(2):161-72 [15838659] Cancer Res. 2005 Aug 1;65(15):6640-50 [16061644] Cancer Res. 2005 Sep 1;65(17):8034-41 [16140978] Cancer Res. 2005 Dec 15;65(24):11779-84 [16357191] J Androl. 2006 Mar-Apr;27(2):138-50 [16330661] Cancer Lett. 2006 Apr 8;235(1):84-92 [15990223] Invest New Drugs. 2006 Sep;24(5):393-401 [16505951] Biochemistry. 2006 Jul 25;45(29):8940-51 [16846237] Clin Pharmacol Ther. 2006 Aug;80(2):192-201 [16890580] Physiol Rev. 2006 Oct;86(4):1179-236 [17015488] Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6094-9 [17062685] Pharmacol Ther. 2006 Nov;112(2):457-73 [16766035] Cancer Metastasis Rev. 2007 Mar;26(1):39-57 [17323127] BMC Urol. 2007;7:6 [17425799] Mol Cancer Ther. 2007 Jun;6(6):1877-85 [17575116] Mol Pharmacol. 2008 Jan;73(1):12-7 [18094074] Clin Cancer Res. 2001 Jan;7(1):145-52 [11205902] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62 [11352869] J Expo Anal Environ Epidemiol. 2001 May-Jun;11(3):155-68 [11477514] Prostate. 2002 Aug 1;52(3):213-35 [12111697] Mol Cancer Ther. 2002 Jun;1(8):611-6 [12479221] J Biol Chem. 2003 Jun 6;278(23):20645-51 [12668685] Cancer Res. 2003 Oct 1;63(19):6447-52 [14559835] Br J Cancer. 2003 Nov 17;89(10):1971-8 [14612912] Int J Cancer. 2004 Mar 20;109(2):238-46 [14750175] J Biol Chem. 2004 May 7;279(19):19781-9 [15001581] Carcinogenesis. 1991 Aug;12(8):1503-6 [1860171] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1464-410X.2008.07913.x ER - TY - JOUR T1 - Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin. AN - 69832295; 18671821 AB - Anthrax lethal toxin (LT) rapidly kills macrophages from certain mouse strains in a mechanism dependent on the breakdown of unknown protein(s) by the proteasome, formation of the Nalp1b (NLRP1b) inflammasome and subsequent activation of caspase-1. We report that heat-shocking LT-sensitive macrophages rapidly protects them against cytolysis by inhibiting caspase-1 activation without upstream effects on LT endocytosis or cleavage of the toxin's known cytosolic substrates (mitogen-activated protein kinases). Heat shock protection against LT occurred through a mechanism independent of de novo protein synthesis, HSP90 activity, p38 activation or proteasome inhibition and was downstream of mitogen-activated protein kinase cleavage and degradation of an unknown substrate by the proteasome. The heat shock inhibition of LT-mediated caspase-1 activation was not specific to the Nalp1b (NLRP1b) inflammasome, as heat shock also inhibited Nalp3 (NLRP3) inflammasome-mediated caspase-1 activation in macrophages. We found that heat shock induced pro-caspase-1 association with a large cellular complex that could prevent its activation. Additionally, while heat-shocking recombinant caspase-1 did not affect its activity in vitro, lysates from heat-shocked cells completely inhibited recombinant active caspase-1 activity. Our results suggest that heat shock inhibition of active caspase-1 can occur independently of an inflammasome platform, through a titratable factor present within intact, functioning heat-shocked cells. JF - Cellular microbiology AU - Levin, Tera C AU - Wickliffe, Katherine E AU - Leppla, Stephen H AU - Moayeri, Mahtab AD - Bacterial Toxins and Therapeutics Section, Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2434 EP - 2446 VL - 10 IS - 12 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Antigens, Bacterial KW - Apoptosis Regulatory Proteins KW - Bacterial Toxins KW - Carrier Proteins KW - Caspase Inhibitors KW - NALP1 protein, mouse KW - NLR Family, Pyrin Domain-Containing 3 Protein KW - Nlrp3 protein, mouse KW - anthrax toxin KW - Caspase 1 KW - EC 3.4.22.36 KW - Index Medicus KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Animals KW - Carrier Proteins -- metabolism KW - Apoptosis Regulatory Proteins -- metabolism KW - Mice KW - Cell Line KW - Cell Survival KW - Macrophages -- enzymology KW - Antigens, Bacterial -- toxicity KW - Hot Temperature KW - Caspase 1 -- metabolism KW - Bacterial Toxins -- toxicity KW - Macrophages -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69832295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+microbiology&rft.atitle=Heat+shock+inhibits+caspase-1+activity+while+also+preventing+its+inflammasome-mediated+activation+by+anthrax+lethal+toxin.&rft.au=Levin%2C+Tera+C%3BWickliffe%2C+Katherine+E%3BLeppla%2C+Stephen+H%3BMoayeri%2C+Mahtab&rft.aulast=Levin&rft.aufirst=Tera&rft.date=2008-12-01&rft.volume=10&rft.issue=12&rft.spage=2434&rft.isbn=&rft.btitle=&rft.title=Cellular+microbiology&rft.issn=1462-5822&rft_id=info:doi/10.1111%2Fj.1462-5822.2008.01220.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-12 N1 - Date created - 2008-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunol Lett. 2007 Feb 15;108(2):137-42 [17196259] J Immunol. 2007 Mar 15;178(6):3944-53 [17339495] Nat Immunol. 2007 May;8(5):497-503 [17435760] EMBO J. 1987 Jan;6(1):55-61 [3034579] J Biol Chem. 1989 Jul 5;264(19):11099-102 [2500434] J Clin Invest. 1991 May;87(5):1674-80 [2022738] Immunology. 1991 Jul;73(3):304-8 [1908820] Science. 2008 May 2;320(5876):674-7 [18403674] Nat Immunol. 2008 Aug;9(8):866-72 [18604212] Biochem Biophys Res Commun. 1999 Jan 8;254(1):264-8 [9920768] J Immunol. 2007 Jul 15;179(2):1236-44 [17617616] J Leukoc Biol. 2007 Aug;82(2):220-5 [17442855] J Biol Chem. 2007 Aug 10;282(32):23240-52 [17556362] Infect Immun. 1993 Jan;61(1):245-52 [8380282] Am J Physiol. 1993 Dec;265(6 Pt 2):R1447-57 [8285289] Endocrinology. 1995 May;136(5):2294-302 [7720678] Blood. 1996 Mar 15;87(6):2095-147 [8630372] J Biol Chem. 1997 Apr 4;272(14):9086-92 [9083035] J Biol Chem. 1997 Oct 17;272(42):26595-603 [9334240] J Exp Med. 1997 Oct 20;186(8):1315-22 [9334371] Mol Cell Biol. 1998 Jan;18(1):30-8 [9418850] Mol Med. 1998 Feb;4(2):87-95 [9508786] J Biol Chem. 1998 Mar 27;273(13):7523-8 [9516453] Science. 1998 May 1;280(5364):734-7 [9563949] Semin Immunopathol. 2007 Sep;29(3):249-60 [17805541] Mol Biol Cell. 2007 Nov;18(11):4279-91 [17699585] Curr Cancer Drug Targets. 2007 Jun;7(4):369-88 [17979631] J Biol Chem. 2007 Nov 23;282(47):34260-7 [17878154] J Immunol. 2007 Dec 15;179(12):8305-12 [18056375] Curr Opin Immunol. 2007 Dec;19(6):615-22 [17977705] J Leukoc Biol. 2008 Jan;83(1):13-30 [17875812] Cell Microbiol. 2008 Feb;10(2):332-43 [17850338] FEBS Lett. 1999 Nov 26;462(1-2):199-204 [10580119] Am J Physiol Regul Integr Comp Physiol. 2000 Mar;278(3):R749-56 [10712297] Protein Expr Purif. 2000 Apr;18(3):293-302 [10733882] Cell Biol Int. 2000;24(3):145-52 [10772775] Crit Care Med. 2000 May;28(5):1465-8 [10834697] Biol Chem. 2000 Sep-Oct;381(9-10):1017-23 [11076035] Biochem J. 2000 Dec 15;352 Pt 3:739-45 [11104681] J Exp Biol. 2002 Feb;205(Pt 4):443-54 [11893758] Nat Rev Immunol. 2002 Mar;2(3):185-94 [11913069] J Ind Microbiol Biotechnol. 2002 Apr;28(4):232-8 [11986925] Science. 2002 Sep 20;297(5589):2048-51 [12202685] Cell Mol Life Sci. 2002 Oct;59(10):1640-8 [12475174] J Cell Biol. 2003 Mar 31;160(7):1139-50 [12668662] Nat Rev Genet. 2003 Apr;4(4):263-74 [12671657] J Immunol. 2003 Jul 15;171(2):664-8 [12847231] J Biol Chem. 2003 Aug 22;278(34):32266-74 [12805360] Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12426-31 [14519843] J Biol Chem. 2004 May 14;279(20):20563-6 [15010463] Infect Immun. 2004 Aug;72(8):4439-47 [15271901] Infect Immun. 1999 Jun;67(6):3055-60 [10338520] Biochem Biophys Res Commun. 2005 Jun 24;332(1):83-8 [15896302] Cancer Res. 2005 Jun 1;65(11):4836-43 [15930304] Cancer Immunol Immunother. 2006 Mar;55(3):292-8 [15864585] Int J Hyperthermia. 2005 Dec;21(8):681-7 [16338849] Cell Cycle. 2006 Jan;5(1):100-6 [16357526] Nat Genet. 2006 Feb;38(2):240-4 [16429160] Nature. 2006 Mar 9;440(7081):237-41 [16407889] Nature. 2006 Mar 9;440(7081):228-32 [16407890] Nat Immunol. 2006 Jun;7(6):569-75 [16648853] Int J Hyperthermia. 2006 Jun;22(4):263-73 [16754348] Neurol Clin. 2006 Aug;24(3):421-39, v [16877116] Proc Natl Acad Sci U S A. 2006 Aug 29;103(35):13092-7 [16916933] J Immunother. 2006 Nov-Dec;29(6):606-15 [17063123] Immunology. 2007 Feb;120(2):230-41 [17116171] J Biol Chem. 2007 Feb 2;282(5):2871-9 [17132626] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1462-5822.2008.01220.x ER - TY - JOUR T1 - Reperfusion-associated hemorrhagic transformation in SHR rats: evidence of symptomatic parenchymal hematoma. AN - 69828615; 18757286 AB - Symptomatic hemorrhagic transformation (HT) is the most important complicating factor after treatment with intravenous tissue plasminogen activator. In this study, we used multimodal magnetic resonance imaging to investigate the incidence and severity of reperfusion-based HT in spontaneously hypertensive rats after ischemia/reperfusion. Twenty male spontaneously hypertensive rats were subjected to 30 minutes of middle cerebral artery occlusion via the suture model. Diffusion-weighted, T(2)-weighted, and gradient-echo imaging were performed on days 1, 2, 3, 4, and 7 for longitudinal evaluation of lesion evolution, vasogenic edema, and HT, respectively. Findings on gradient-echo images were classified according to the severity of hemorrhage: no HT; punctate or small petechial hemorrhage (HI-1); confluent petechial hemorrhage (HI-2); hematoma with absent/mild space-occupying effect (PH-1, 30% lesion volume). Histopathologic evaluation of HT was performed after final imaging for comparison with magnetic resonance imaging results. Final hemorrhage scores based on severity were as follows: HI-1 23.1%, HI-2 30.8%, PH-1 30.8%, and PH-2 15.4%. Similar to clinical observations, only PH-2 was associated with neurologic deterioration and associated weight loss. This model has a high incidence of parenchymal hematomas (46.2%) and therefore is appropriate for the evaluation of novel therapeutics targeting blood-brain barrier integrity and the reduction of symptomatic HT events (PH-2), as well as those potentially "at risk" for neurologic deterioration (PH-1). JF - Stroke AU - Henning, Erica C AU - Latour, Lawrence L AU - Hallenbeck, John M AU - Warach, Steven AD - Section on Stroke Diagnostics and Therapeutics, Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. henninge@ninds.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3405 EP - 3410 VL - 39 IS - 12 KW - Fibrinolytic Agents KW - 0 KW - Recombinant Proteins KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Rats, Inbred SHR KW - Disease Progression KW - Hypertension -- genetics KW - Recombinant Proteins -- toxicity KW - Blood-Brain Barrier -- drug effects KW - Hypertension -- complications KW - Rats KW - Brain Edema -- etiology KW - Weight Loss KW - Movement Disorders -- etiology KW - Time Factors KW - Male KW - Recombinant Proteins -- therapeutic use KW - Fibrinolytic Agents -- therapeutic use KW - Cerebral Hemorrhage -- chemically induced KW - Infarction, Middle Cerebral Artery -- complications KW - Hematoma -- etiology KW - Hematoma -- pathology KW - Fibrinolytic Agents -- toxicity KW - Tissue Plasminogen Activator -- therapeutic use KW - Infarction, Middle Cerebral Artery -- pathology KW - Tissue Plasminogen Activator -- toxicity KW - Cerebral Hemorrhage -- pathology KW - Infarction, Middle Cerebral Artery -- drug therapy KW - Thrombolytic Therapy -- adverse effects KW - Reperfusion Injury -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69828615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Reperfusion-associated+hemorrhagic+transformation+in+SHR+rats%3A+evidence+of+symptomatic+parenchymal+hematoma.&rft.au=Henning%2C+Erica+C%3BLatour%2C+Lawrence+L%3BHallenbeck%2C+John+M%3BWarach%2C+Steven&rft.aulast=Henning&rft.aufirst=Erica&rft.date=2008-12-01&rft.volume=39&rft.issue=12&rft.spage=3405&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=1524-4628&rft_id=info:doi/10.1161%2FSTROKEAHA.108.520304 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1161/STROKEAHA.108.520304 ER - TY - JOUR T1 - Use of nonsteroidal antiinflammatory drugs and distal large bowel cancer in whites and African Americans. AN - 69824937; 18945689 AB - Despite the belief that the etiology of and risk factors for rectal cancer might differ from those for colon cancer, relatively few studies have examined rectal cancer in relation to use of nonsteroidal antiinflammatory drugs (NSAIDs). The authors evaluated the association between NSAIDs and distal large bowel cancer in African Americans and whites, using data from a population-based case-control study of 1,057 incident cases of adenocarcinoma of the sigmoid colon, rectosigmoid junction, and rectum and 1,019 controls from North Carolina (2001-2006). NSAID use was inversely associated with distal large bowel cancer in whites (odds ratio (OR) = 0.60, 95% confidence interval (CI): 0.46, 0.79). The inverse association was evident for all types of NSAIDs but was slightly stronger with prescription NSAIDs, particularly selective cyclooxygenase 2 inhibitors (OR = 0.38, 95% CI: 0.25, 0.56). Compared with whites, a relatively weak inverse association was found in African Americans (OR = 0.87, 95% CI: 0.55, 1.40), although odds ratio heterogeneity by race could not be confirmed (P = 0.21). In addition, the strength of the association with NSAIDs varied by tumor location, suggesting more potent effects for rectal and rectosigmoid cancers than for sigmoid cancer. The chemopreventive potential of NSAIDs might differ by population and by tumor characteristics. JF - American journal of epidemiology AU - Kim, Sangmi AU - Martin, Christopher AU - Galanko, Joseph AU - Woosley, John T AU - Schroeder, Jane C AU - Keku, Temitope O AU - Satia, Jessie A AU - Halabi, Susan AU - Sandler, Robert S AD - Epidemiology Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Kims3@niehs.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 1292 EP - 1300 VL - 168 IS - 11 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase 2 Inhibitors KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - North Carolina -- epidemiology KW - Male KW - Female KW - Cyclooxygenase 2 Inhibitors -- adverse effects KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- adverse effects KW - Cyclooxygenase 2 Inhibitors -- therapeutic use KW - African Americans -- statistics & numerical data KW - European Continental Ancestry Group -- statistics & numerical data KW - Colorectal Neoplasms -- epidemiology KW - Colorectal Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69824937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Use+of+nonsteroidal+antiinflammatory+drugs+and+distal+large+bowel+cancer+in+whites+and+African+Americans.&rft.au=Kim%2C+Sangmi%3BMartin%2C+Christopher%3BGalanko%2C+Joseph%3BWoosley%2C+John+T%3BSchroeder%2C+Jane+C%3BKeku%2C+Temitope+O%3BSatia%2C+Jessie+A%3BHalabi%2C+Susan%3BSandler%2C+Robert+S&rft.aulast=Kim&rft.aufirst=Sangmi&rft.date=2008-12-01&rft.volume=168&rft.issue=11&rft.spage=1292&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwn255 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-22 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 1998 Jun 15;82(12):2326-33 [9635524] Br J Cancer. 1997;76(5):675-7 [9303370] Arch Intern Med. 1999 Jan 25;159(2):161-6 [9927099] N Engl J Med. 1999 Jun 17;340(24):1888-99 [10369853] J Am Geriatr Soc. 1999 Jun;47(6):749-54 [10366179] Br J Cancer. 1999 Sep;81(1):62-8 [10487613] Gut. 1999 Nov;45(5):730-2 [10517910] J Surg Oncol. 2004 Dec 15;88(4):261-6 [15565587] JAMA. 2005 Jul 6;294(1):47-55 [15998890] Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1613-8 [16030091] Am J Epidemiol. 2005 Sep 15;162(6):548-58 [16093288] Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):494-501 [16537707] Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1785-90 [17035383] Ann Intern Med. 2007 Mar 6;146(5):365-75 [17339622] N Engl J Med. 2007 May 24;356(21):2131-42 [17522398] Cancer Causes Control. 2000 Mar;11(3):249-55 [10782659] BMJ. 2000 Jun 17;320(7250):1642-6 [10856067] Clin Infect Dis. 2000 Oct;31 Suppl 5:S202-10 [11113024] Curr Opin Oncol. 2001 Jan;13(1):63-9 [11148689] Annu Rev Pharmacol Toxicol. 2002;42:55-80 [11807164] J Natl Cancer Inst. 2002 Feb 20;94(4):252-66 [11854387] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1305-15 [12433707] Gastroenterology. 2002 Dec;123(6):1770-7 [12454832] Ann Pharmacother. 2003 Jan;37(1):136-42 [12503949] N Engl J Med. 2003 Mar 6;348(10):883-90 [12621132] N Engl J Med. 2003 Mar 6;348(10):891-9 [12621133] Int J Gastrointest Cancer. 2002;31(1-3):147-54 [12622426] Pharmacoepidemiol Drug Saf. 2003 Jun;12(4):315-26 [12812012] Lancet Oncol. 2003 Oct;4(10):605-15 [14554238] Cancer Lett. 2004 Nov 8;215(1):1-20 [15374627] Am J Epidemiol. 1991 Aug 15;134(4):421-32 [1877602] Med Sci Sports Exerc. 1993 Jan;25(1):71-80 [8292105] J Natl Cancer Inst. 1993 Aug 4;85(15):1220-4 [8331682] Cancer. 1993 Aug 15;72(4):1171-7 [8339210] Arch Intern Med. 1994 Feb 28;154(4):394-9 [8117171] Ann Intern Med. 1994 Aug 15;121(4):241-6 [8037405] Cancer. 1994 Oct 1;74(7):1847-54 [8082089] Breast Cancer Res Treat. 1995 Jul;35(1):61-4 [7612905] N Engl J Med. 1995 Sep 7;333(10):609-14 [7637720] Am J Epidemiol. 1995 Nov 15;142(10):1103-12 [7485055] Cancer Epidemiol Biomarkers Prev. 1996 Dec;5(12):955-60 [8959316] Cancer. 1997 Feb 1;79(3):441-7 [9028352] Cancer. 1997 Jul 15;80(2):193-7 [9217029] J Natl Cancer Inst. 1998 Nov 4;90(21):1609-20 [9811310] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwn255 ER - TY - JOUR T1 - A low-molecular-weight antagonist for the human thyrotropin receptor with therapeutic potential for hyperthyroidism. AN - 69817957; 18669595 AB - Low-molecular-weight (LMW) antagonists for TSH receptor (TSHR) may have therapeutic potential as orally active drugs to block stimulating antibodies (TsAbs) in Graves' hyperthyroidism. We describe an approach to identify LMW ligands for TSHR based on Org41841, a LMW partial agonist for the LH/choriogonadotropin receptor and TSHR. We used molecular modeling and functional experiments to guide the chemical modification of Org41841. We identified an antagonist (NIDDK/CEB-52) that selectively inhibits activation of TSHR by both TSH and TsAbs. Whereas initially characterized in cultured cells overexpressing TSHRs, the antagonist was also active under more physiologically relevant conditions in primary cultures of human thyrocytes expressing endogenous TSHRs in which it inhibited TSH- and TsAb-induced up-regulation of mRNA transcripts for thyroperoxidase. Our results establish this LMW compound as a lead for the development of higher potency antagonists and serve as proof of principle that LMW ligands that target TSHR could serve as drugs in patients with Graves' disease. JF - Endocrinology AU - Neumann, Susanne AU - Kleinau, Gunnar AU - Costanzi, Stefano AU - Moore, Susanna AU - Jiang, Jian-kang AU - Raaka, Bruce M AU - Thomas, Craig J AU - Krause, Gerd AU - Gershengorn, Marvin C AD - National Institute of Diabetes and Digestive and Kidney Diseases, Clinical Endocrinology Branch, National Institutes of Health, 50 South Drive, Bethesda, Maryland 20892-8029, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 5945 EP - 5950 VL - 149 IS - 12 SN - 0013-7227, 0013-7227 KW - Antithyroid Agents KW - 0 KW - Receptors, Thyrotropin KW - Abridged Index Medicus KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Molecular Structure KW - Computer Simulation KW - Cells, Cultured KW - Humans KW - Protein Binding -- genetics KW - Molecular Weight KW - Cell Line KW - Receptors, Thyrotropin -- metabolism KW - Hyperthyroidism -- drug therapy KW - Antithyroid Agents -- chemical synthesis KW - Hyperthyroidism -- metabolism KW - Receptors, Thyrotropin -- antagonists & inhibitors KW - Antithyroid Agents -- pharmacology KW - Receptors, Thyrotropin -- genetics KW - Antithyroid Agents -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69817957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=A+low-molecular-weight+antagonist+for+the+human+thyrotropin+receptor+with+therapeutic+potential+for+hyperthyroidism.&rft.au=Neumann%2C+Susanne%3BKleinau%2C+Gunnar%3BCostanzi%2C+Stefano%3BMoore%2C+Susanna%3BJiang%2C+Jian-kang%3BRaaka%2C+Bruce+M%3BThomas%2C+Craig+J%3BKrause%2C+Gerd%3BGershengorn%2C+Marvin+C&rft.aulast=Neumann&rft.aufirst=Susanne&rft.date=2008-12-01&rft.volume=149&rft.issue=12&rft.spage=5945&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/10.1210%2Fen.2008-0836 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-31 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Biochem Sci. 2004 Mar;29(3):119-26 [15003269] Chembiochem. 2002 Oct 4;3(10):928-44 [12362358] J Mol Biol. 1993 Jun 20;231(4):1049-67 [8515464] J Virol. 1998 Jan;72(1):279-85 [9420225] J Biol Chem. 1999 Apr 2;274(14):9617-26 [10092648] Nature. 2005 Jan 20;433(7023):269-77 [15662415] Drug Discov Today. 2005 Jul 1;10(13):895-907 [15993809] Mol Pharmacol. 2005 Nov;68(5):1271-80 [16099840] J Biol Chem. 2006 Apr 14;281(15):9841-4 [16488885] J Med Chem. 2006 Jun 29;49(13):3888-96 [16789744] Drug Discov Today. 2006 Jul;11(13-14):580-94 [16793526] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8 [17060607] J Biol Chem. 2007 Jan 5;282(1):518-25 [17079233] Curr Top Med Chem. 2007;7(10):1006-14 [17508934] J Comput Aided Mol Des. 2007 Aug;21(8):437-53 [17668276] J Mol Biol. 2007 Oct 5;372(5):1179-88 [17825322] ChemMedChem. 2007 Oct;2(10):1388-401 [17806089] Nature. 2007 Nov 15;450(7168):383-7 [17952055] Science. 2007 Nov 23;318(5854):1258-65 [17962520] J Biomol Screen. 2008 Feb;13(2):120-7 [18216391] Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11304-9 [15277683] Science. 2000 Aug 4;289(5480):739-45 [10926528] Virology. 2001 Sep 1;287(2):382-90 [11531415] Physiol Rev. 2002 Apr;82(2):473-502 [11917095] J Med Chem. 2002 Apr 11;45(8):1712-22 [11931626] Endocr Rev. 2002 Apr;23(2):141-74 [11943741] Comment In: Endocrinology. 2008 Dec;149(12):5943-4 [19022900] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2008-0836 ER - TY - JOUR T1 - Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers. AN - 69814129; 18799724 AB - Graft-versus-tumor effects can be achieved after allogeneic bone marrow transplantation in patients with malignancies of the kidney or hematopoietic system but are often accompanied by severe graft-versus-host-disease (GVHD). We sought to maximize graft-versus-tumor while minimizing GVHD using tumor-specific allogeneic effector T cells rather than open-repertoire T cells. We transferred allogeneic CD8(+) pmel-1 or CD4(+) TRP-1 T cells specific for the melanoma-associated antigens, glycoprotein 100 (gp100) and tyrosinase-related protein-1 (TRP-1), respectively, into B16-melanoma-bearing mice. Mice receiving a preparative regimen of nonmyeloablating (5 Gy) total body irradiation experienced the rapid rejection of tumor-specific allogeneic lymphocytes with no impact on tumor growth. However, when mice were given more intense total body irradiation conditioning regimens combined with autologous bone marrow transplantation, adoptively transferred allogeneic tumor-specific T lymphocytes persisted at detectable levels for several weeks and mediated significant regression of large, vascularized tumors. We found that the risk of GVHD was low when tumor-specific T cells were transferred and significant toxicity was observed only when substantial numbers of open repertoire allogeneic naive T cells were mixed with the tumor-specific lymphocytes. Taken together, these data indicate that the use of tumor-specific allogeneic CD8(+) T cells or CD4(+) can result in significant antitumor effects in the absence of measurable GVHD. JF - Blood AU - Boni, Andrea AU - Muranski, Pawel AU - Cassard, Lydie AU - Wrzesinski, Claudia AU - Paulos, Chrystal M AU - Palmer, Douglas C AU - Gattinoni, Luca AU - Hinrichs, Christian S AU - Chan, Chi-Chao AU - Rosenberg, Steven A AU - Restifo, Nicholas P AD - Clinical Research Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 4746 EP - 4754 VL - 112 IS - 12 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Transplantation, Homologous -- physiology KW - Graft vs Host Disease -- immunology KW - Graft vs Tumor Effect -- immunology KW - Mice KW - Mice, Transgenic KW - Graft vs Host Disease -- prevention & control KW - Melanoma, Experimental -- pathology KW - Mice, Inbred BALB C KW - Melanoma, Experimental -- immunology KW - Melanoma, Experimental -- therapy KW - Mice, Inbred DBA KW - Graft vs Tumor Effect -- genetics KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Remission Induction -- methods KW - Transplantation, Homologous -- immunology KW - Female KW - Lymphocytes, Tumor-Infiltrating -- physiology KW - Lymphocytes, Tumor-Infiltrating -- immunology KW - Blood Group Incompatibility -- genetics KW - Adoptive Transfer -- methods KW - Blood Group Incompatibility -- immunology KW - Major Histocompatibility Complex -- physiology KW - Tumor Burden -- immunology KW - Lymphocytes, Tumor-Infiltrating -- transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69814129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Adoptive+transfer+of+allogeneic+tumor-specific+T+cells+mediates+effective+regression+of+large+tumors+across+major+histocompatibility+barriers.&rft.au=Boni%2C+Andrea%3BMuranski%2C+Pawel%3BCassard%2C+Lydie%3BWrzesinski%2C+Claudia%3BPaulos%2C+Chrystal+M%3BPalmer%2C+Douglas+C%3BGattinoni%2C+Luca%3BHinrichs%2C+Christian+S%3BChan%2C+Chi-Chao%3BRosenberg%2C+Steven+A%3BRestifo%2C+Nicholas+P&rft.aulast=Boni&rft.aufirst=Andrea&rft.date=2008-12-01&rft.volume=112&rft.issue=12&rft.spage=4746&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/10.1182%2Fblood-2008-07-169797 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-12 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bone Marrow Transplant. 2005 Jun;35(12):1127-32 [15834432] J Immunother. 2005 Jul-Aug;28(4):281-8 [16000944] Cancer Immunol Immunother. 2005 Aug;54(8):721-8 [16010587] Lancet. 2005 Jul 23-29;366(9482):318-20 [16039336] J Exp Med. 2005 Oct 3;202(7):907-12 [16203864] J Immunother. 2005 Nov-Dec;28(6):517-24 [16224268] J Immunol. 2005 Nov 15;175(10):7046-52 [16272366] Nat Rev Immunol. 2006 May;6(5):383-93 [16622476] Nature. 2006 Apr 27;440(7088):1123 [16641981] Immunol Rev. 2006 Jun;211:214-24 [16824130] Immunol Rev. 2008 Jun;223:334-60 [18613846] J Cell Mol Med. 2009 Aug;13(8B):1962-76 [18624776] Bone Marrow Transplant. 2003 May;31(10):943-5 [12748675] J Clin Invest. 2003 Jul;112(1):101-8 [12840064] J Immunother. 2003 Jul-Aug;26(4):332-42 [12843795] J Exp Med. 2003 Aug 18;198(4):569-80 [12925674] Science. 2003 Oct 17;302(5644):415-9 [14564000] Transfusion. 2003 Dec;43(12):1667-71 [14641861] Annu Rev Med. 2004;55:459-75 [14746531] Nat Clin Pract Oncol. 2008 May;5(5):256-67 [18398414] N Engl J Med. 2000 Sep 14;343(11):750-8 [10984562] Cancer Immunol Immunother. 2001 Mar;50(1):3-15 [11315507] J Clin Oncol. 2002 Apr 15;20(8):2017-24 [11956260] Bone Marrow Transplant. 2002 Jul;30(2):95-102 [12132048] Lancet. 2002 Aug 10;360(9331):436-42 [12241714] N Engl J Med. 2003 Jan 16;348(3):255-6 [12529469] Nature. 2003 Feb 20;421(6925):852-6 [12594515] Bone Marrow Transplant. 2003 Feb;31(4):253-61 [12621459] Science. 2003 Apr 11;300(5617):337-9 [12690201] Blood. 2004 Feb 15;103(4):1534-41 [14551132] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1969-74 [14762166] Pancreas. 2004 Apr;28(3):e65-9 [15084986] J Clin Oncol. 2004 Oct 1;22(19):3886-92 [15314059] Nat Immunol. 2004 Nov;5(11):1143-8 [15475958] Blood. 1992 Jul 15;80(2):551-5 [1627807] Blood. 1995 Mar 1;85(5):1207-14 [7858251] J Exp Med. 1996 Mar 1;183(3):725-9 [8642276] Lancet. 1996 Aug 17;348(9025):472-3 [8709796] Ann Surg Oncol. 1996 Jan;3(1):67-73 [8770305] J Immunol. 1996 Dec 1;157(11):4811-21 [8943383] J Exp Med. 1998 Mar 2;187(5):693-702 [9480979] Hum Gene Ther. 2005 Jan;16(1):35-48 [15703487] Immunity. 2005 Mar;22(3):371-83 [15780993] Blood. 2006 Sep 15;108(6):1797-808 [16741253] Nat Clin Pract Oncol. 2006 Dec;3(12):668-81 [17139318] J Clin Invest. 2007 Feb;117(2):492-501 [17273561] Gene Ther. 2007 Mar;14(6):491-502 [17203106] Front Biosci. 2007;12:2922-34 [17485269] Blood. 2007 Jun 15;109(12):5168-77 [17353346] J Clin Invest. 2007 Aug;117(8):2197-204 [17657310] Blood. 2007 Aug 15;110(4):1123-31 [17468341] J Control Release. 2007 Sep 11;122(1):102-10 [17628160] Curr Opin Hematol. 2007 Nov;14(6):616-24 [17898565] Blood. 2007 Oct 15;110(8):2793-802 [17638856] Hematology Am Soc Hematol Educ Program. 2007;:460-5 [18024665] Nat Rev Immunol. 2007 Dec;7(12):942-53 [18007679] Semin Immunol. 2007 Oct;19(5):318-30 [18023361] J Immunol. 2008 Mar 1;180(5):3122-31 [18292535] Nat Rev Cancer. 2008 Apr;8(4):299-308 [18354418] Nat Biotechnol. 2008 Apr;26(4):453-61 [18376399] Blood. 2008 Apr 15;111(8):4392-402 [17878399] Biol Blood Marrow Transplant. 2008 May;14(5):518-30 [18410894] Exp Hematol. 2000 Nov;28(11):1225-31 [11063870] Trends Immunol. 2008 May;29(5):235-41 [18375183] Immunol Cell Biol. 2008 May-Jun;86(4):312-9 [18362947] Blood. 2008 May 15;111(10):5242-51 [18285547] Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8061-6 [18523011] J Immunol. 2008 Jul 1;181(1):165-73 [18566381] N Engl J Med. 2008 Jun 19;358(25):2698-703 [18565862] Blood. 2008 Jul 15;112(2):362-73 [18354038] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] J Immunother. 2005 May-Jun;28(3):258-67 [15838383] Lancet Oncol. 2005 May;6(5):344-6 [15863383] J Clin Invest. 2005 Jun;115(6):1616-26 [15931392] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1182/blood-2008-07-169797 ER - TY - JOUR T1 - A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. AN - 69806245; 18799805 AB - Cytochrome P450 3A4 (CYP3A4), the most abundant human cytochrome P450 in liver, participates in the metabolism of approximately 50% of clinically used drugs. The pregnane X receptor (PXR), a member of the nuclear receptor superfamily, is the major activator of CYP3A4 transcription. However, because of species differences in response to PXR ligands, it is problematic to use rodents to assess CYP3A4 regulation and function. The generation of double transgenic mice expressing human PXR and CYP3A4 (TgCYP3A4/hPXR) would provide a solution to this problem. In the current study, a TgCYP3A4/hPXR mouse model was generated by bacterial artificial chromosome transgenesis in Pxr-null mice. In TgCYP3A4/hPXR mice, CYP3A4 was strongly induced by rifampicin, a human-specific PXR ligand, but not by pregnenolone 16alpha-carbonitrile, a rodent-specific PXR ligand. Consistent with CYP3A expression, hepatic CYP3A activity increased approximately 5-fold in TgCYP3A4/hPXR mice pretreated with rifampicin. Most antihuman immunodeficiency virus protease inhibitors are CYP3A substrates and their interactions with rifamycins are a source of major concern in patients coinfected with human immunodeficiency virus and Mycobacterium tuberculosis. By using TgCYP3A4/hPXR mice, human PXR-CYP3A4-mediated rifampicin-protease inhibitor interactions were recapitulated, as the metabolic stability of amprenavir, nelfinavir, and saquinavir decreased 52, 53, and 99%, respectively, in the liver microsomes of TgCYP3A4/hPXR mice pretreated with rifampicin. In vivo, rifampicin pretreatment resulted in an approximately 80% decrease in the area under the serum amprenavir concentration-time curve in TgCYP3A4/hPXR mice. These results suggest that the TgCYP3A4/hPXR mouse model could serve as a useful tool for studies on CYP3A4 transcription and function in vivo. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Ma, Xiaochao AU - Cheung, Connie AU - Krausz, Kristopher W AU - Shah, Yatrik M AU - Wang, Ting AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2506 EP - 2512 VL - 36 IS - 12 KW - Carbamates KW - 0 KW - Cytochrome P-450 Enzyme Inhibitors KW - HIV Protease Inhibitors KW - Receptors, Steroid KW - Sulfonamides KW - pregnane X receptor KW - Pregnenolone Carbonitrile KW - 1434-54-4 KW - amprenavir KW - 5S0W860XNR KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - CYP3A protein, mouse KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP3A KW - Nelfinavir KW - HO3OGH5D7I KW - Saquinavir KW - L3JE09KZ2F KW - Ketoconazole KW - R9400W927I KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Sex Characteristics KW - Humans KW - Microsomes, Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Liver -- metabolism KW - Carbamates -- pharmacokinetics KW - Mice, Transgenic KW - Mice, Knockout KW - Carbamates -- metabolism KW - Liver -- drug effects KW - Microsomes, Liver -- drug effects KW - HIV Protease Inhibitors -- pharmacokinetics KW - Intestine, Small -- drug effects KW - Ketoconazole -- pharmacology KW - Male KW - Pregnenolone Carbonitrile -- pharmacology KW - Intestine, Small -- metabolism KW - Mice KW - Drug Interactions -- physiology KW - Nelfinavir -- metabolism KW - Sulfonamides -- pharmacokinetics KW - Sulfonamides -- metabolism KW - Gene Expression Regulation -- physiology KW - Rifampin -- pharmacology KW - Saquinavir -- metabolism KW - Female KW - HIV Protease Inhibitors -- metabolism KW - Models, Animal KW - Cytochrome P-450 CYP3A -- metabolism KW - Receptors, Steroid -- genetics KW - Cytochrome P-450 CYP3A -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69806245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=A+double+transgenic+mouse+model+expressing+human+pregnane+X+receptor+and+cytochrome+P450+3A4.&rft.au=Ma%2C+Xiaochao%3BCheung%2C+Connie%3BKrausz%2C+Kristopher+W%3BShah%2C+Yatrik+M%3BWang%2C+Ting%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Ma&rft.aufirst=Xiaochao&rft.date=2008-12-01&rft.volume=36&rft.issue=12&rft.spage=2506&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.108.022723 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-05 N1 - Date created - 2008-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Drug Metab. 2004 Dec;5(6):483-505 [15578943] J Pharmacol Exp Ther. 1994 Oct;271(1):549-56 [7965755] Curr Drug Metab. 2005 Aug;6(4):357-67 [16101574] Annu Rev Pharmacol Toxicol. 2006;46:41-64 [16402898] J Pharmacol Exp Ther. 2006 Mar;316(3):1328-34 [16291874] Trop Doct. 2006 Apr;36(2):73-9 [16611437] Drugs. 2006;66(18):2299-308 [17181373] Drug Metab Dispos. 2007 Feb;35(2):194-200 [17093002] Curr Drug Metab. 2007 Feb;8(2):185-94 [17305497] J Antimicrob Chemother. 2007 Apr;59(4):690-7 [17307771] Mol Endocrinol. 2000 Jan;14(1):27-39 [10628745] Nature. 2000 Jul 27;406(6794):435-9 [10935643] Drug Metab Dispos. 2000 Sep;28(9):1051-7 [10950848] Antimicrob Agents Chemother. 2001 Feb;45(2):502-8 [11158747] Biochem Biophys Res Commun. 2001 Mar16;281(5):1349-55 [11243885] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74 [11248085] Pharmacogenetics. 2001 Mar;11(2):111-21 [11266076] Acta Pharmacol Sin. 2001 Oct;22(10):944-8 [11749780] Protein Expr Purif. 2002 Apr;24(3):329-37 [11922748] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8 [12509506] J Mass Spectrom. 2003 Feb;38(2):157-66 [12577282] Biochem Pharmacol. 1995 Nov 27;50(11):1841-50 [8615863] J Clin Invest. 1998 Sep 1;102(5):1016-23 [9727070] Annu Rev Pharmacol Toxicol. 1999;39:1-17 [10331074] J Biol Chem. 1999 Aug 20;274(34):23963-8 [10446164] Drug Metab Dispos. 2003 May;31(5):548-58 [12695342] Mol Pharmacol. 2003 Jul;64(1):42-50 [12815159] Drug Metab Dispos. 2003 Aug;31(8):1054-64 [12867495] Clin Pharmacokinet. 2003;42(9):819-50 [12882588] Hepatology. 2003 Oct;38(4):978-88 [14512885] J Biol Chem. 2003 Nov 14;278(46):45062-71 [12923173] Drug Metab Dispos. 2004 Feb;32(2):163-7 [14744936] Pharmacogenomics. 2004 Apr;5(3):243-72 [15102541] J Biol Chem. 1987 Oct 5;262(28):13534-7 [3654629] Clin Pharmacol Ther. 1990 Oct;48(4):365-74 [2121408] Biochemistry. 1990 Dec 25;29(51):11280-92 [2271712] Endocrinology. 2005 Jul;146(7):2911-9 [15817670] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/dmd.108.022723 ER - TY - JOUR T1 - Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. AN - 69801324; 18712364 AB - Serotonin transporter (SERT) knockout (-/-) mice have an altered phenotype in adulthood, including high baseline anxiety and depressive-like behaviors, associated with increased baseline extracellular serotonin levels throughout life. To examine the effects of increases in serotonin following the administration of the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) in SERT wild-type (+/+), heterozygous (+/-), and -/- mice. 5-HTP increased serotonin in all five brain areas examined with approximately 2- to 5-fold increases in SERT+/+ and +/- mice, and with greater 4.5- to 11.7-fold increases in SERT-/- mice. Behaviorally, 5-HTP induced exaggerated serotonin syndrome behaviors in SERT-/-, mice with similar effects in male and female mice. Studies suggest promiscuous serotonin uptake by the dopamine transporter (DAT) in SERT-/- mice, and here, the DAT blocker GBR 12909 enhanced 5-HTP-induced behaviors in SERT-/- mice. Physiologically, 5-HTP induced exaggerated temperature effects in SERT-deficient mice. The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only. WAY 100635 and SB 269970 together completely blocked 5-HTP-induced hypothermia in SERT+/- and -/- mice. These studies demonstrate that SERT-/- mice have exaggerated neurochemical, behavioral, and physiological responses to further increases in serotonin, and provide the first evidence of intact 5-HT7 receptor function in SERT-/- mice, with interesting interactions between 5-HT1A and 5-HT7 receptors. As roles for 5-HT7 receptors in anxiety and depression were recently established, the current findings have implications for understanding the high anxiety and depressive-like phenotype of SERT-deficient mice. JF - Psychopharmacology AU - Fox, Meredith A AU - Jensen, Catherine L AU - French, Helen T AU - Stein, Alison R AU - Huang, Su-Jan AU - Tolliver, Teresa J AU - Murphy, Dennis L AD - Laboratory of Clinical Science (LCS), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), 10 Center Drive, Building 10-3D41, MSC 1264, Bethesda, MD 20892-1264, USA. mfox@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 203 EP - 218 VL - 201 IS - 2 SN - 0033-3158, 0033-3158 KW - Catecholamines KW - 0 KW - Dopamine Uptake Inhibitors KW - Monoamine Oxidase Inhibitors KW - Phenols KW - Piperazines KW - Pyridines KW - SB 269970 KW - Serotonin 5-HT1 Receptor Antagonists KW - Serotonin Plasma Membrane Transport Proteins KW - Serotonin Receptor Agonists KW - Sulfonamides KW - Serotonin KW - 333DO1RDJY KW - Tranylcypromine KW - 3E3V44J4Z9 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide KW - 71IH826FEG KW - 8-Hydroxy-2-(di-n-propylamino)tetralin KW - 78950-78-4 KW - vanoxerine KW - 90X28IKH43 KW - 5-carboxamidotryptamine KW - 91H76044O0 KW - 5-Hydroxytryptophan KW - C1LJO185Q9 KW - Clorgyline KW - LYJ16FZU9Q KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Animals KW - Hydroxyindoleacetic Acid -- analysis KW - Brain -- drug effects KW - Catecholamines -- classification KW - Brain -- metabolism KW - Catecholamines -- antagonists & inhibitors KW - Piperazines -- pharmacology KW - Monoamine Oxidase Inhibitors -- pharmacology KW - Mice, Knockout KW - Tranylcypromine -- pharmacology KW - Sulfonamides -- pharmacology KW - Brain -- anatomy & histology KW - Hypothermia -- chemically induced KW - Clorgyline -- pharmacology KW - Serotonin Syndrome -- chemically induced KW - Drug Synergism KW - Male KW - Dopamine Uptake Inhibitors -- pharmacology KW - Phenols -- pharmacology KW - Hydroxyindoleacetic Acid -- metabolism KW - Mice KW - Piperazines -- toxicity KW - Drug Therapy, Combination KW - 8-Hydroxy-2-(di-n-propylamino)tetralin -- pharmacology KW - 5-Hydroxytryptophan -- pharmacology KW - Pyridines -- pharmacology KW - Female KW - Serotonin -- pharmacology KW - Serotonin Plasma Membrane Transport Proteins -- deficiency KW - Brain Chemistry -- drug effects KW - Serotonin -- analogs & derivatives KW - Serotonin -- metabolism KW - Serotonin Plasma Membrane Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69801324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Neurochemical%2C+behavioral%2C+and+physiological+effects+of+pharmacologically+enhanced+serotonin+levels+in+serotonin+transporter+%28SERT%29-deficient+mice.&rft.au=Fox%2C+Meredith+A%3BJensen%2C+Catherine+L%3BFrench%2C+Helen+T%3BStein%2C+Alison+R%3BHuang%2C+Su-Jan%3BTolliver%2C+Teresa+J%3BMurphy%2C+Dennis+L&rft.aulast=Fox&rft.aufirst=Meredith&rft.date=2008-12-01&rft.volume=201&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-008-1268-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-24 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Pharmacol. 1998 Apr;53(4):649-55 [9547354] J Clin Psychiatry. 1998;59 Suppl 15:4-12 [9786305] Depress Anxiety. 1998;8 Suppl 1:5-12 [9809208] J Neurosci Methods. 2004 Dec 30;140(1-2):169-81 [15589347] Neuropharmacology. 2005 Mar;48(4):492-502 [15755477] Psychopharmacology (Berl). 2005 Jun;180(1):12-20 [15834538] Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):1074-84 [15939518] Neuropharmacology. 2005 Nov;49(6):798-810 [16183083] Biol Psychiatry. 2005 Nov 15;58(10):831-7 [16018977] Eur J Pharmacol. 2006 Feb 27;532(3):258-64 [16488409] Gene Expr. 2006;13(1):53-7 [16572590] Trends Cogn Sci. 2006 Apr;10(4):182-91 [16530463] Am J Hum Genet. 2006 May;78(5):815-26 [16642437] Neuroscience. 2006 Jun 19;140(1):321-34 [16542782] Neurosci Lett. 2006 Jun 19;401(1-2):49-54 [16638624] J Neurosci. 2006 May 17;26(20):5554-64 [16707806] J Neurosci. 2000 Nov 1;20(21):7888-95 [11050108] Brain Res Dev Brain Res. 2001 Jan 31;126(1):125-9 [11172895] J Pharmacol Exp Ther. 2001 Mar;296(3):987-95 [11181933] Eur J Neurosci. 2001 Apr;13(7):1349-62 [11298795] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5300-5 [11320258] J Neurosci. 2001 Sep 1;21(17):6862-73 [11517274] Pharmacol Biochem Behav. 2002 Apr;71(4):555-68 [11888547] Brain Res. 2002 Jun 28;942(1-2):109-19 [12031859] J Pharmacol Exp Ther. 2002 Jul;302(1):240-8 [12065723] Endocrinology. 2002 Dec;143(12):4520-6 [12446578] Neuropsychopharmacology. 2002 Dec;27(6):914-23 [12464448] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1375-80 [12529502] J Neurosci Res. 2003 Mar 1;71(5):701-9 [12584728] Neurosci Lett. 2006 Aug 14;404(1-2):122-6 [16759802] Neuropharmacology. 2006 Sep;51(3):578-86 [16828124] Eur J Pharmacol. 2006 Dec 28;553(1-3):185-90 [17097082] Eur J Pharmacol. 2007 Jan 19;555(1):43-7 [17109856] J Neurosci. 2007 Jan 17;27(3):684-91 [17234600] J Pharmacol Exp Ther. 2007 May;321(2):690-8 [17314195] J Pharmacol Exp Ther. 2007 Jun;321(3):1054-61 [17337633] Genes Brain Behav. 2007 Jun;6(4):389-400 [16939636] Biol Psychiatry. 2007 Aug 15;62(4):327-31 [17210141] Neuropharmacology. 2007 Oct;53(5):643-56 [17765930] Psychopharmacology (Berl). 2007 Dec;195(2):147-66 [17712549] Trends Pharmacol Sci. 2007 Dec;28(12):629-36 [17996955] J Neurosci. 2008 Jan 2;28(1):199-207 [18171937] Mol Psychiatry. 2008 Feb;13(2):131-46 [17700575] Nat Rev Neurosci. 2008 Feb;9(2):85-96 [18209729] J Neurosci. 2008 Apr 2;28(14):3546-54 [18385313] J Neurosci. 2003 Oct 1;23(26):8836-43 [14523084] Eur J Neurosci. 2003 Oct;18(8):2203-12 [14622181] Neuropsychopharmacology. 2003 Dec;28(12):2077-88 [12968128] Genes Brain Behav. 2003 Dec;2(6):365-80 [14653308] Eur J Pharmacol. 2004 Mar 8;487(1-3):125-32 [15033384] Mol Interv. 2004 Apr;4(2):109-23 [15087484] Brain Res Dev Brain Res. 2004 Jun 21;150(2):151-61 [15158078] Neuropsychopharmacology. 2004 Oct;29(10):1790-9 [15226739] Science. 2004 Oct 29;306(5697):879-81 [15514160] Life Sci. 1976 Sep 15;19(6):777-85 [823389] J Pharmacol Exp Ther. 1984 Jan;228(1):133-9 [6694097] Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):783-6 [6141618] Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):653-6 [6531436] Eur J Pharmacol. 1985 Dec 17;119(3):143-52 [4092729] Neuropharmacology. 1985 Dec;24(12):1187-94 [2869435] Pharmacol Biochem Behav. 1986 Jun;24(6):1513-9 [2942947] Psychopharmacology (Berl). 1986;90(4):488-93 [2949333] Psychopharmacology (Berl). 1987;91(4):500-5 [2954178] Psychopharmacology (Berl). 1987;91(4):506-11 [2954179] Eur J Pharmacol. 1988 Sep 23;154(3):299-304 [2976671] Br J Pharmacol. 1991 Aug;103(4):1857-64 [1833017] Nature. 1991 Nov 7;354(6348):66-70 [1944572] Br J Pharmacol. 1992 Sep;107(1):15-21 [1422568] J Neurochem. 1993 Mar;60(3):1167-70 [8094744] Pharmacol Rev. 1994 Jun;46(2):157-203 [7938165] J Pharmacol Exp Ther. 1999 Dec;291(3):999-1007 [10565817] Br J Pharmacol. 2000 Jun;130(3):539-48 [10821781] Eur J Neurosci. 2000 Jul;12(7):2299-310 [10947809] Neuroreport. 2003 Feb 10;14(2):233-8 [12598736] Neuropharmacology. 2003 Jun;44(8):1031-7 [12763096] J Neurochem. 2003 Jul;86(1):210-9 [12807440] Science. 2003 Jul 18;301(5631):386-9 [12869766] Science. 1996 Nov 29;274(5292):1527-31 [8929413] Neurosci Lett. 1997 May 9;227(1):53-6 [9178857] J Pharmacol Exp Ther. 1997 Aug;282(2):699-706 [9262333] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00213-008-1268-7 ER - TY - JOUR T1 - Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. AN - 69796090; 18809576 AB - Nuclear factor of activated T cells (NFAT) was first described as an activation and differentiation transcription factor in lymphocytes. Several in vitro studies suggest that NFAT family members are redundant proteins. However, analysis of mice deficient for NFAT proteins suggested different roles for the NFAT family of transcription factors in the regulation of cell proliferation and apoptosis. NFAT may also regulate several cell cycle and survival factors influencing tumor growth and survival. Here, we demonstrate that two constitutively active forms of NFAT proteins (CA-NFAT1 and CA-NFAT2 short isoform) induce distinct phenotypes in NIH 3T3 cells. Whereas CA-NFAT1 expression induces cell cycle arrest and apoptosis in NIH 3T3 fibroblasts, CA-NFAT2 short isoform leads to increased proliferation capacity and induction of cell transformation. Furthermore, NFAT1-deficient mice showed an increased propensity for chemical carcinogen-induced tumor formation, and CA-NFAT1 expression subverted the transformation of NIH 3T3 cells induced by the H-rasV12 oncogene. The differential roles for NFAT1 are at least partially due to the protein C-terminal domain. These results suggest that the NFAT1 gene acts as a tumor suppressor gene and the NFAT2 short isoform acts gene as an oncogene, supporting different roles for the two transcription factors in tumor development. JF - Molecular and cellular biology AU - Robbs, Bruno K AU - Cruz, Andre L S AU - Werneck, Miriam B F AU - Mognol, Giuliana P AU - Viola, João P B AD - Division of Cellular Biology, Brazilian National Cancer Institute, Rio de Janeiro, Brazil. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 7168 EP - 7181 VL - 28 IS - 23 KW - NFATC Transcription Factors KW - 0 KW - Nfatc1 protein, mouse KW - Nfatc2 protein, mouse KW - Protein Isoforms KW - Index Medicus KW - Phenotype KW - Animals KW - 3T3 Cells KW - Apoptosis KW - Mice KW - Mice, Inbred BALB C KW - Cell Proliferation KW - Cell Cycle KW - Cell Transformation, Neoplastic -- genetics KW - Mice, Knockout KW - Oncogenes KW - NFATC Transcription Factors -- genetics KW - Genes, Tumor Suppressor KW - NFATC Transcription Factors -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69796090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Dual+roles+for+NFAT+transcription+factor+genes+as+oncogenes+and+tumor+suppressors.&rft.au=Robbs%2C+Bruno+K%3BCruz%2C+Andre+L+S%3BWerneck%2C+Miriam+B+F%3BMognol%2C+Giuliana+P%3BViola%2C+Jo%C3%A3o+P+B&rft.aulast=Robbs&rft.aufirst=Bruno&rft.date=2008-12-01&rft.volume=28&rft.issue=23&rft.spage=7168&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=1098-5549&rft_id=info:doi/10.1128%2FMCB.00256-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-06 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1998 Mar 12;392(6672):186-90 [9515964] Nature. 1998 Mar 12;392(6672):182-6 [9515963] Immunity. 1998 Nov;9(5):627-35 [9846484] Immunity. 1999 Feb;10(2):261-9 [10072078] J Immunol. 1999 Jun 15;162(12):7294-301 [10358178] Blood. 2004 Nov 15;104(10):3358-60 [15297316] Nature. 2004 Nov 18;432(7015):307-15 [15549092] Br J Haematol. 2005 Feb;128(3):333-42 [15667535] J Biol Chem. 2005 Mar 11;280(10):8686-93 [15632146] Braz J Med Biol Res. 2005 Mar;38(3):335-44 [15761612] Nat Rev Immunol. 2005 Jun;5(6):472-84 [15928679] Blood. 2005 Nov 15;106(10):3546-52 [16051745] Blood. 2005 Dec 1;106(12):3940-7 [16099873] Blood. 2006 Jun 1;107(11):4540-8 [16497967] EMBO J. 2006 Aug 9;25(15):3714-24 [16874304] Oncogene. 2006 Sep 14;25(41):5640-7 [16619034] Nature. 2006 Sep 21;443(7109):345-9 [16988714] Nat Med. 2007 Jun;13(6):736-41 [17515895] Cell Cycle. 2007 Jul 15;6(14):1789-95 [17637565] Am J Pathol. 2008 Jan;172(1):215-24 [18156209] J Exp Med. 2000 Jan 3;191(1):9-22 [10620601] Cell. 2000 Jan 7;100(1):57-70 [10647931] Mol Cell Biol. 2000 Jun;20(12):4309-19 [10825194] J Biol Chem. 2000 Aug 4;275(31):23627-35 [10816557] Mol Cell. 2000 Sep;6(3):539-50 [11030334] Biochem Biophys Res Commun. 2000 Sep 24;276(2):466-71 [11027498] J Biol Chem. 2001 Apr 27;276(17):14350-8 [11278367] Mol Cells. 2002 Feb 28;13(1):77-84 [11911478] Immunity. 2002 Jun;16(6):881-95 [12121669] Eur J Immunol. 2002 Oct;32(10):2971-8 [12355451] Mol Cell. 2002 Nov;10(5):1071-81 [12453415] FASEB J. 2002 Dec;16(14):1940-2 [12368232] Blood. 2003 Feb 15;101(4):1505-12 [12393731] J Biol Chem. 2003 May 9;278(19):17246-54 [12598522] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D523-7 [14681473] Cell. 1991 Jan 25;64(2):313-26 [1988150] Nature. 1992 Jun 25;357(6380):695-7 [1377362] Immunity. 1996 Apr;4(4):397-405 [8612134] Science. 1996 May 10;272(5263):892-5 [8629027] Nature. 1996 Jul 25;382(6589):370-3 [8684469] J Exp Med. 1996 Jul 1;184(1):141-7 [8691127] Annu Rev Immunol. 1997;15:707-47 [9143705] J Biol Chem. 1997 Dec 12;272(50):31427-34 [9395475] Immunity. 1998 Jan;8(1):115-24 [9462517] Eur J Immunol. 1998 Aug;28(8):2456-66 [9710223] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/MCB.00256-08 ER - TY - JOUR T1 - Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. AN - 69791961; 18977148 AB - Compounds that stabilize p53 could suppress tumors providing a additional tool to fight cancer. Mdm2, and the human ortholog, Hdm2 serve as ubiquitin E3 ligases and target p53 for ubiquitylation and degradation. Inhibition of Hdm2 stabilizes p53, inhibits cell proliferation and induces apoptosis. Using HTS to discover inhibitors, we identified three new alkaloids, isolissoclinotoxin B, diplamine B, and lissoclinidine B from Lissoclinum cf. badium. Lissoclinidine B inhibited ubiquitylation and degradation of p53, and selectively killed transformed cells harboring wild-type p53, suggesting this compound could be used to develop new treatments. JF - Bioorganic & medicinal chemistry AU - Clement, Jason A AU - Kitagaki, Jirouta AU - Yang, Yili AU - Saucedo, Carrie J AU - O'Keefe, Barry R AU - Weissman, Allan M AU - McKee, Tawnya C AU - McMahon, James B AD - Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA. Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 10022 EP - 10028 VL - 16 IS - 23 KW - Acridines KW - 0 KW - Alkaloids KW - Enzyme Inhibitors KW - Phenanthrolines KW - Tumor Suppressor Protein p53 KW - Ubiquitin KW - pyridoacridine KW - MDM2 protein, human KW - EC 2.3.2.27 KW - Proto-Oncogene Proteins c-mdm2 KW - Index Medicus KW - Animals KW - Ubiquitin -- metabolism KW - Phenanthrolines -- chemistry KW - Humans KW - Acridines -- isolation & purification KW - Phenanthrolines -- metabolism KW - Phenanthrolines -- isolation & purification KW - Inhibitory Concentration 50 KW - Cell Line, Transformed KW - Acridines -- metabolism KW - Acridines -- chemistry KW - Alkaloids -- chemistry KW - Enzyme Inhibitors -- chemistry KW - Proto-Oncogene Proteins c-mdm2 -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - Alkaloids -- pharmacology KW - Alkaloids -- isolation & purification KW - Proto-Oncogene Proteins c-mdm2 -- metabolism KW - Enzyme Inhibitors -- isolation & purification KW - Urochordata -- chemistry KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69791961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Discovery+of+new+pyridoacridine+alkaloids+from+Lissoclinum+cf.+badium+that+inhibit+the+ubiquitin+ligase+activity+of+Hdm2+and+stabilize+p53.&rft.au=Clement%2C+Jason+A%3BKitagaki%2C+Jirouta%3BYang%2C+Yili%3BSaucedo%2C+Carrie+J%3BO%27Keefe%2C+Barry+R%3BWeissman%2C+Allan+M%3BMcKee%2C+Tawnya+C%3BMcMahon%2C+James+B&rft.aulast=Clement&rft.aufirst=Jason&rft.date=2008-12-01&rft.volume=16&rft.issue=23&rft.spage=10022&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=1464-3391&rft_id=info:doi/10.1016%2Fj.bmc.2008.10.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-09 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Mar 24;275(12):8945-51 [10722742] J Biomol Screen. 2008 Mar;13(3):229-37 [18270365] J Am Chem Soc. 2001 Jan 31;123(4):554-60 [11456567] J Nat Prod. 2001 Sep;64(9):1169-73 [11575950] Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3529-34 [11891335] Cancer Lett. 2002 Sep 8;183(1):69-77 [12049816] Nat Rev Cancer. 2003 Feb;3(2):102-9 [12563309] J Nat Prod. 2003 Feb;66(2):247-50 [12608858] J Nat Prod. 2003 Jul;66(7):1022-37 [12880330] Science. 2004 Feb 6;303(5659):844-8 [14704432] Oncogene. 2004 Mar 15;23(11):2096-106 [15021897] Cell Mol Life Sci. 2004 Jul;61(13):1546-61 [15224180] J Med Chem. 1989 Jun;32(6):1354-9 [2724306] Science. 1991 Jun 21;252(5013):1708-11 [2047879] Cell. 1993 Sep 24;74(6):957-67 [8402885] J Nat Prod. 1994 Oct;57(10):1336-45 [7807120] J Nat Prod. 1995 Feb;58(2):254-8 [7769392] Nature. 1995 Nov 9;378(6553):203-6 [7477326] Nature. 1995 Nov 9;378(6553):206-8 [7477327] Mol Med. 1995 Jan;1(2):142-52 [8529093] Nature. 1997 May 15;387(6630):296-9 [9153395] Nature. 1997 May 15;387(6630):299-303 [9153396] FEBS Lett. 1997 Dec 22;420(1):25-7 [9450543] Nucleic Acids Res. 1998 Aug 1;26(15):3453-9 [9671804] Mol Med. 1999 Jan;5(1):21-34 [10072445] Nat Med. 2004 Dec;10(12):1321-8 [15558054] J Biomol Screen. 2004 Dec;9(8):695-703 [15634796] Curr Cancer Drug Targets. 2005 Feb;5(1):43-9 [15720188] World J Gastroenterol. 2005 May 21;11(19):2927-31 [15902730] Cancer Cell. 2005 Jun;7(6):547-59 [15950904] Genes Dev. 2006 Jan 15;20(2):125-31 [16418478] Cell Death Differ. 2006 Jun;13(6):1027-36 [16557269] J Med Chem. 2006 Jun 15;49(12):3432-5 [16759082] Nat Rev Mol Cell Biol. 2007 Apr;8(4):275-83 [17380161] Cell. 2007 Aug 24;130(4):597-600 [17719538] Biochemistry. 2001 Jan 16;40(2):336-44 [11148027] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bmc.2008.10.024 ER - TY - JOUR T1 - Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide. AN - 69778523; 18812491 AB - A variety of peptide ligands are known to inhibit the function of neuronal nicotinic acetylcholine receptors (nAChRs), including small toxins and brain-derived peptides such as beta-amyloid(1-42) and synthetic apolipoproteinE peptides. The myristoylated alanine-rich C kinase substrate (MARCKS) protein is a major substrate of protein kinase C and is highly expressed in the developing and adult brain. The ability of a 25-amino acid synthetic MARCKS peptide, derived from the effector domain (ED), to modulate nAChR activity was tested. To determine the effects of the MARCKS ED peptide on nAChR function, receptors were expressed in Xenopus laevis oocytes, and two-electrode voltage-clamp experiments were performed. The MARCKS ED peptide completely inhibited acetylcholine (ACh)-evoked responses from alpha7 nAChRs in a dose-dependent manner, yielding an IC(50) value of 16 nM. Inhibition of ACh-induced responses was both activity- and voltage-independent. The MARCKS ED peptide was unable to block alpha-bungarotoxin binding. A MARCKS ED peptide in which four serine residues were replaced with aspartate residues was unable to inhibit alpha7 nAChR-mediated currents. The MARCKS ED peptide inhibited ACh-induced alpha4beta2 and alpha2beta2 responses, although with decreased potency. The effects of the MARCKS ED peptide on native nAChRs were tested using acutely isolated rat hippocampal slices. In hippocampal interneurons, the MARCKS ED peptide was able to block native alpha7 nAChRs in a dose-dependent manner. The MARCKS ED peptide represents a novel antagonist of neuronal nAChRs that has considerable utility as a research tool. JF - The Journal of pharmacology and experimental therapeutics AU - Gay, Elaine A AU - Klein, Rebecca C AU - Melton, Mark A AU - Blackshear, Perry J AU - Yakel, Jerrel L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 884 EP - 890 VL - 327 IS - 3 KW - Chrna7 protein, human KW - 0 KW - Chrna7 protein, rat KW - Intracellular Signaling Peptides and Proteins KW - Membrane Proteins KW - Nicotinic Antagonists KW - Receptors, Nicotinic KW - Recombinant Proteins KW - alpha7 Nicotinic Acetylcholine Receptor KW - myristoylated alanine-rich C kinase substrate KW - 125267-21-2 KW - Index Medicus KW - Rats KW - Xenopus laevis KW - Animals KW - Dose-Response Relationship, Drug KW - Oocytes KW - Inhibitory Concentration 50 KW - Electrophysiology KW - Mutation, Missense KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Receptors, Nicotinic -- drug effects KW - Membrane Proteins -- genetics KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Membrane Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69778523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+native+and+recombinant+nicotinic+acetylcholine+receptors+by+the+myristoylated+alanine-rich+C+kinase+substrate+peptide.&rft.au=Gay%2C+Elaine+A%3BKlein%2C+Rebecca+C%3BMelton%2C+Mark+A%3BBlackshear%2C+Perry+J%3BYakel%2C+Jerrel+L&rft.aulast=Gay&rft.aufirst=Elaine&rft.date=2008-12-01&rft.volume=327&rft.issue=3&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.144758 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-05 N1 - Date created - 2008-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2006 Sep;318(3):956-65 [16740622] Hippocampus. 2006;16(5):495-503 [16572394] J Pharmacol Exp Ther. 2001 Aug;298(2):395-402 [11454899] Mol Pharmacol. 2002 Jan;61(1):43-54 [11752205] Biochem J. 2002 Feb 15;362(Pt 1):1-12 [11829734] J Physiol. 2000 Sep 15;527 Pt 3:515-28 [10990538] J Neurosci. 2001 Jan 1;21(1):RC120 [11150356] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4734-9 [11274373] Eur J Neurosci. 2001 May;13(10):1849-60 [11403678] J Biol Chem. 2002 Jul 12;277(28):25056-61 [11983690] J Physiol. 2003 Feb 15;547(Pt 1):147-57 [12562926] Nat Struct Biol. 2003 Mar;10(3):226-31 [12577052] Br J Pharmacol. 2003 Jul;139(6):1061-73 [12871824] J Neurosci. 2003 Jul 30;23(17):6740-7 [12890766] J Neurosci. 2003 Oct 8;23(27):9024-31 [14534236] Biochem Cell Biol. 2004 Feb;82(1):191-200 [15052337] J Neurochem. 2004 Jul;90(2):325-31 [15228589] Neuroscience. 2004;127(3):563-7 [15283956] J Biol Chem. 2004 Sep 3;279(36):37842-51 [15234980] J Physiol. 1988 Jan;395:131-59 [2457675] J Biol Chem. 1989 Dec 25;264(36):21818-23 [2557340] J Neurosci. 1990 May;10(5):1683-98 [2332803] J Biol Chem. 1991 Aug 5;266(22):14390-8 [1650359] Cell. 1992 Nov 27;71(5):713-6 [1423627] J Physiol. 1992 Aug;454:155-82 [1282155] J Biol Chem. 1993 Jan 25;268(3):1501-4 [8420923] Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):944-8 [7862670] J Biol Chem. 1996 Jan 5;271(1):553-62 [8550618] J Biol Chem. 1997 Sep 19;272(38):23833-42 [9295331] Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14517-22 [9826732] Exp Neurol. 2005 Mar;192(1):109-16 [15698624] Neurosci Lett. 2005 Jun 24;381(3):305-8 [15896489] Hippocampus. 2005;15(5):675-83 [15889447] J Mol Neurosci. 2005;27(1):13-21 [16055943] Neuron. 2005 Oct 6;48(1):77-90 [16202710] J Pharmacol Exp Ther. 2006 Feb;316(2):835-42 [16249370] Biochem Pharmacol. 2007 Oct 15;74(8):1092-101 [17662959] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.144758 ER - TY - JOUR T1 - Acute 5-HT reuptake blockade potentiates human amygdala reactivity. AN - 69773069; 18463627 AB - Variability in serotonin (5-HT) function is associated with individual differences in normal mood and temperament, as well as psychiatric illnesses, all of which are influenced by amygdala function. This study evaluated the acute effects of 5-HT reuptake blockade on amygdala function using pharmacological functional MRI. Eight healthy men completed a double-blind balanced crossover study with the selective 5-HT reuptake inhibitor, citalopram (20 mg infused over 30 min), and normal saline. Amygdala reactivity in response to novel facial expressions was assessed on three successive scans, once before drug/placebo infusion, once early in the infusion, and once at the end of infusion. Acute citalopram administration resulted in concentration-dependent increases in human amygdala reactivity to salient stimuli. The current pattern of 5-HT-mediated amygdala reactivity may represent an important pathway through which SSRIs achieve an antidepressant effect. Intriguingly, our data may also reveal a mechanism contributing to clinical observations of extreme agitation, restlessness, and suicidal ideation in some individuals during acute SSRI treatment. Developing a comprehensive model of how 5-HT modulates human amygdala reactivity supporting behavioral and physiological arousal will be instrumental for our understanding of basic neurobehavioral processes, their dysfunction in psychiatric illnesses, and their contribution to mechanism of treatment response. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Bigos, Kristin L AU - Pollock, Bruce G AU - Aizenstein, Howard J AU - Fisher, Patrick M AU - Bies, Robert R AU - Hariri, Ahmad R AD - Department of Pharmaceutical Sciences, University of Pittsburgh, PA, USA. bigosk@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 3221 EP - 3225 VL - 33 IS - 13 KW - Serotonin Uptake Inhibitors KW - 0 KW - Citalopram KW - 0DHU5B8D6V KW - Serotonin KW - 333DO1RDJY KW - Index Medicus KW - Young Adult KW - Akathisia, Drug-Induced -- metabolism KW - Anxiety -- metabolism KW - Double-Blind Method KW - Anxiety -- chemically induced KW - Dose-Response Relationship, Drug KW - Humans KW - Anxiety -- physiopathology KW - Akathisia, Drug-Induced -- physiopathology KW - Presynaptic Terminals -- metabolism KW - Facial Expression KW - Presynaptic Terminals -- drug effects KW - Photic Stimulation KW - Adult KW - Cross-Over Studies KW - Depressive Disorder -- physiopathology KW - Depressive Disorder -- drug therapy KW - Middle Aged KW - Serotonin Uptake Inhibitors -- pharmacology KW - Neuropsychological Tests KW - Depressive Disorder -- metabolism KW - Male KW - Amygdala -- metabolism KW - Brain Chemistry -- drug effects KW - Citalopram -- pharmacology KW - Amygdala -- drug effects KW - Serotonin -- metabolism KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69773069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Acute+5-HT+reuptake+blockade+potentiates+human+amygdala+reactivity.&rft.au=Bigos%2C+Kristin+L%3BPollock%2C+Bruce+G%3BAizenstein%2C+Howard+J%3BFisher%2C+Patrick+M%3BBies%2C+Robert+R%3BHariri%2C+Ahmad+R&rft.aulast=Bigos&rft.aufirst=Kristin&rft.date=2008-12-01&rft.volume=33&rft.issue=13&rft.spage=3221&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.52 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-19 N1 - Date created - 2008-11-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chem Neuroanat. 2001 Sep;22(3):185-203 [11522440] Trends Pharmacol Sci. 2007 Dec;28(12):629-36 [17996955] Neuroimage. 2003 Jul;19(3):1233-9 [12880848] Neuroimage. 2004 Jan;21(1):450-5 [14741682] Biol Psychiatry. 2004 Jun 15;55(12):1171-8 [15184036] J Cogn Neurosci. 2004 Jun;16(5):786-93 [15200706] Magn Reson Med. 1995 May;33(5):636-47 [7596267] Psychopharmacol Bull. 1997;33(1):109-12 [9133760] Neuropsychopharmacology. 1999 Aug;21(2 Suppl):91S-98S [10432494] Nat Neurosci. 2005 Jan;8(1):20-1 [15592465] Mol Psychiatry. 2005 Sep;10(9):884-8, 805 [16044172] Trends Cogn Sci. 2006 Apr;10(4):182-91 [16530463] Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6269-74 [16569698] Biol Psychiatry. 2006 May 1;59(9):816-20 [16460693] Neuroscience. 2006 Aug 25;141(2):1047-55 [16713119] Nat Neurosci. 2006 Nov;9(11):1362-3 [17013380] JAMA. 2007 Apr 18;297(15):1683-96 [17440145] Neuroscience. 2007 Apr 25;146(1):306-20 [17331657] J Neurosci. 2007 Aug 22;27(34):9233-7 [17715358] Biol Psychiatry. 2007 Nov 15;62(10):1111-8 [17524369] Science. 2002 Jul 19;297(5580):400-3 [12130784] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.52 ER - TY - JOUR T1 - Repression of small toxic protein synthesis by the Sib and OhsC small RNAs. AN - 69770199; 18710431 AB - The sequences encoding the QUAD1 RNAs were initially identified as four repeats in Escherichia coli. These repeats, herein renamed SIB, are conserved in closely related bacteria, although the number of repeats varies. All five Sib RNAs in E. coli MG1655 are expressed, and no phenotype was observed for a five-sib deletion strain. However, a phenotype reminiscent of plasmid addiction was observed for overexpression of the Sib RNAs, and further examination of the SIB repeat sequences revealed conserved open reading frames encoding highly hydrophobic 18- to 19-amino-acid proteins (Ibs) opposite each sib gene. The Ibs proteins were found to be toxic when overexpressed and this toxicity could be prevented by coexpression of the corresponding Sib RNA. Two other RNAs encoded divergently in the yfhL-acpS intergenic region were similarly found to encode a small hydrophobic protein (ShoB) and an antisense RNA regulator (OhsC). Overexpression of both IbsC and ShoB led to immediate changes in membrane potential suggesting both proteins affect the cell envelope. Whole genome expression analysis showed that overexpression of IbsC and ShoB, as well as the small hydrophobic LdrD and TisB proteins, has both overlapping and unique consequences for the cell. JF - Molecular microbiology AU - Fozo, Elizabeth M AU - Kawano, Mitsuoki AU - Fontaine, Fanette AU - Kaya, Yusuf AU - Mendieta, Kathy S AU - Jones, Kristi L AU - Ocampo, Alejandro AU - Rudd, Kenneth E AU - Storz, Gisela AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1076 EP - 1093 VL - 70 IS - 5 KW - RNA, Bacterial KW - 0 KW - Index Medicus KW - Gene Expression Regulation, Bacterial KW - Transformation, Bacterial KW - Genes, Bacterial KW - Base Sequence KW - Sequence Alignment KW - Oligonucleotide Array Sequence Analysis KW - Genome, Bacterial KW - Open Reading Frames KW - Molecular Sequence Data KW - Membrane Potentials KW - Repetitive Sequences, Nucleic Acid KW - Gene Deletion KW - Protein Biosynthesis KW - Escherichia coli -- metabolism KW - Escherichia coli -- genetics KW - RNA, Bacterial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69770199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Repression+of+small+toxic+protein+synthesis+by+the+Sib+and+OhsC+small+RNAs.&rft.au=Fozo%2C+Elizabeth+M%3BKawano%2C+Mitsuoki%3BFontaine%2C+Fanette%3BKaya%2C+Yusuf%3BMendieta%2C+Kathy+S%3BJones%2C+Kristi+L%3BOcampo%2C+Alejandro%3BRudd%2C+Kenneth+E%3BStorz%2C+Gisela&rft.aulast=Fozo&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=70&rft.issue=5&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=1365-2958&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06394.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-26 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Bacteriol. 1995 Jul;177(14):4121-30 [7608087] Gene. 1995 May 26;158(1):9-14 [7789817] Curr Biol. 2004 Dec 29;14(24):2271-6 [15620655] Nucleic Acids Res. 2005;33(3):1040-50 [15718303] Nat Rev Microbiol. 2005 May;3(5):371-82 [15864262] Mol Microbiol. 2005 Aug;57(3):621-8 [16045608] J Bacteriol. 2005 Oct;187(20):6962-71 [16199566] Mol Microbiol. 2006 Jan;59(1):231-47 [16359331] PLoS Biol. 2006 Jan;4(1):e2 [16336047] Mol Syst Biol. 2006;2:2006.0007 [16738553] Curr Opin Microbiol. 2007 Apr;10(2):117-24 [17376733] Curr Opin Microbiol. 2007 Apr;10(2):96-101 [17383222] Mol Microbiol. 2007 May;64(3):738-54 [17462020] Mol Cell. 2007 May 11;26(3):381-92 [17499044] Curr Opin Microbiol. 2007 Jun;10(3):257-61 [17553733] Mol Microbiol. 2007 Oct;66(1):100-9 [17725563] Mol Microbiol. 1999 Jun;32(5):1090-102 [10361310] Res Microbiol. 1999 Nov-Dec;150(9-10):653-64 [10673004] Antimicrob Agents Chemother. 2000 Mar;44(3):682-7 [10681338] Proc Natl Acad Sci U S A. 2000 May 23;97(11):5978-83 [10811905] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] Genes Dev. 2001 Jul 1;15(13):1637-51 [11445539] Curr Biol. 2001 Jun 26;11(12):941-50 [11448770] Curr Biol. 2001 Sep 4;11(17):1369-73 [11553332] Mol Microbiol. 2002 Jul;45(2):333-49 [12123448] Nucleic Acids Res. 2003 Apr 1;31(7):1813-20 [12654996] Science. 2003 Sep 12;301(5639):1496-9 [12970556] Gene. 2003 Oct 2;315:63-9 [14557065] J Bacteriol. 2004 Oct;186(20):6698-705 [15466020] EMBO J. 1986 Aug;5(8):2023-9 [3019679] Gene. 1987;53(1):85-96 [3596251] Gene. 1989 Apr 15;77(1):61-8 [2744488] J Mol Biol. 1991 Jul 5;220(1):35-48 [1712397] Erratum In: Mol Microbiol. 2008 Dec;70(5):1305 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06394.x ER - TY - JOUR T1 - Trastuzumab cardiotoxicity: biological hypotheses and clinical open issues. AN - 69762284; 18990083 AB - Trastuzumab has significantly improved the prognosis of breast cancer patients overexpressing the human epidermal growth factor receptor 2 (HER2). This result has been achieved in all disease settings, by increasing overall survival in early stage and advanced disease and by increasing pathological complete responses in neoadjuvant disease. Although the greatest impact of this monoclonal antibody has been seen in the adjuvant setting, by increasing disease-free survival and overall survival rates an increased rate of both symptomatic and non-symptomatic cardiac toxicity has also been observed. In the following review, the different mechanisms of trastuzumab cardiac toxicity are described and, in addition, the clinical data coming from both trials and meta-analyses is discussed. While there is strong evidence for the incidence of trastuzumab-related cardiac toxicity, there is still little known on the exact pathogenesis of this toxicity. Interestingly, both experimental and clinical data suggest that trastuzumab may sensitize cardiomyocytes to injuries and stress from administration of anthracyclines. This has led to a proposed novel mechanism of cardiotoxicity that appears to be quite different from the anthracycline-associated cardiotoxicity. Trastuzumab does not seem to cause any overt ultrastructural abnormality; it does, however, lead to myocardial dysfunction. Most of the proposed hypotheses seems to be related to the activity of trastuzumab in interfering with the ERBB-2 receptor. Indeed, data from clinical trials in the adjuvant setting report increased cardiac toxicity in those patients who previously received anthracyclines. JF - Expert opinion on biological therapy AU - Bria, Emilio AU - Cuppone, Federica AU - Milella, Michele AU - Verma, Sunil AU - Carlini, Paolo AU - Nisticò, Cecilia AU - Vaccaro, Vanja AU - Rossi, Antonio AU - Tonini, Giuseppe AU - Cognetti, Francesco AU - Terzoli, Edmondo AD - Regina Elena National Cancer Institute, Department of Medical Oncology, Via Elio Chianesi 53, 00144, Rome, Italy. emiliobria@yahoo.it Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1963 EP - 1971 VL - 8 IS - 12 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Trastuzumab KW - P188ANX8CK KW - Index Medicus KW - Breast Neoplasms -- drug therapy KW - Survival Rate KW - Breast Neoplasms -- pathology KW - Humans KW - Prognosis KW - Clinical Trials as Topic KW - Heart -- drug effects KW - Antibodies, Monoclonal -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- adverse effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69762284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=Trastuzumab+cardiotoxicity%3A+biological+hypotheses+and+clinical+open+issues.&rft.au=Bria%2C+Emilio%3BCuppone%2C+Federica%3BMilella%2C+Michele%3BVerma%2C+Sunil%3BCarlini%2C+Paolo%3BNistic%C3%B2%2C+Cecilia%3BVaccaro%2C+Vanja%3BRossi%2C+Antonio%3BTonini%2C+Giuseppe%3BCognetti%2C+Francesco%3BTerzoli%2C+Edmondo&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2008-12-01&rft.volume=8&rft.issue=12&rft.spage=1963&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/10.1517%2F14728220802517935 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-04 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/14728220802517935 ER - TY - JOUR T1 - Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. AN - 66717837; 19594501 AB - Attenuation of protein kinase C (PKC) is a mechanism common to both established (lithium, valproate) and some novel (tamoxifen) antimanic agents. Verapamil, although primarily known as a calcium channel blocker, also has PKC inhibitory activity. Verapamil has shown antimanic activity in some but not all studies. Therefore, we investigated verapamil, used alone or as an adjunctive treatment, in manic patients who did not respond to an initial adequate trial of lithium. Each study phase lasted three weeks. Subjects were treated openly with lithium in Phase 1 (n = 45). Those who failed to respond were randomly assigned to double-blind treatment in Phase 2 with either verapamil (n = 10) or continued-lithium (n = 8). Phase 2 nonresponders (n = 10) were assigned to combined verapamil/lithium in Phase 3. Response in Phase 2 did not differ significantly between verapamil and continued-lithium. During Phase 3, response to combined treatment was significantly better than overall response to monotherapy in Phase 2 (Fisher's Exact test, p = 0.043). Mania ratings improved during combined treatment in Phase 3 by 88.2% (linear mixed model analysis, F = 4.34, p = 0.013), compared with 10.5% improvement during Phase 2. In this preliminary investigation, verapamil monotherapy did not demonstrate antimanic efficacy. By contrast, the combination of verapamil plus lithium was highly efficacious. Our findings thus suggest that verapamil may have potential utility as an adjunct to lithium. This effect may be mediated by additive actions on PKC inhibition, which may be an important mechanism for antimanic agents in general. JF - Bipolar disorders AU - Mallinger, Alan G AU - Thase, Michael E AU - Haskett, Roger AU - Buttenfield, Joan AU - Luckenbaugh, David A AU - Frank, Ellen AU - Kupfer, David J AU - Manji, Husseini K AD - Mood and Anxiety Disorders Program, National Institutes of Health Intramural Research Program, Building 10, Room 3N210, MSC 1290, Bethesda, MD 20892, USA. mallingera@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 856 EP - 866 VL - 10 IS - 8 KW - Antimanic Agents KW - 0 KW - Antipsychotic Agents KW - Calcium Channel Blockers KW - Lithium Carbonate KW - 2BMD2GNA4V KW - Verapamil KW - CJ0O37KU29 KW - Perphenazine KW - FTA7XXY4EZ KW - Index Medicus KW - Double-Blind Method KW - Antipsychotic Agents -- therapeutic use KW - Humans KW - Drug Resistance KW - Drug Therapy, Combination KW - Psychiatric Status Rating Scales KW - Perphenazine -- adverse effects KW - Adult KW - Middle Aged KW - Antipsychotic Agents -- adverse effects KW - Female KW - Male KW - Perphenazine -- therapeutic use KW - Lithium Carbonate -- therapeutic use KW - Verapamil -- adverse effects KW - Lithium Carbonate -- adverse effects KW - Calcium Channel Blockers -- adverse effects KW - Bipolar Disorder -- drug therapy KW - Antimanic Agents -- adverse effects KW - Bipolar Disorder -- psychology KW - Antimanic Agents -- therapeutic use KW - Verapamil -- therapeutic use KW - Calcium Channel Blockers -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66717837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bipolar+disorders&rft.atitle=Verapamil+augmentation+of+lithium+treatment+improves+outcome+in+mania+unresponsive+to+lithium+alone%3A+preliminary+findings+and+a+discussion+of+therapeutic+mechanisms.&rft.au=Mallinger%2C+Alan+G%3BThase%2C+Michael+E%3BHaskett%2C+Roger%3BButtenfield%2C+Joan%3BLuckenbaugh%2C+David+A%3BFrank%2C+Ellen%3BKupfer%2C+David+J%3BManji%2C+Husseini+K&rft.aulast=Mallinger&rft.aufirst=Alan&rft.date=2008-12-01&rft.volume=10&rft.issue=8&rft.spage=856&rft.isbn=&rft.btitle=&rft.title=Bipolar+disorders&rft.issn=1399-5618&rft_id=info:doi/10.1111%2Fj.1399-5618.2008.00636.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-03 N1 - Date created - 2009-07-14 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00518947; ClinicalTrials.gov N1 - SuppNotes - Cited By: Biol Psychiatry. 1999 Nov 15;46(10):1328-51 [10578449] Arch Gen Psychiatry. 2000 Jan;57(1):95-7 [10632242] Eur J Pharmacol. 2000 Feb 11;389(1):59-65 [10686296] Psychiatry Res. 2000 Feb 14;93(1):83-7 [10699232] J Clin Psychiatry. 2000;61 Suppl 9:5-15 [10826655] Biol Psychiatry. 2000 Sep 15;48(6):518-30 [11018224] J Affect Disord. 2000 Sep;59 Suppl 1:S31-S37 [11121825] Curr Psychiatry Rep. 2000 Dec;2(6):479-89 [11122999] Bipolar Disord. 2000 Sep;2(3 Pt 2):217-36 [11249800] Am J Psychiatry. 1992 Jan;149(1):118-20 [1728159] Minerva Med. 1991 Nov;82(11):757-63 [1766578] Eur J Pharmacol. 1991 Aug 6;200(2-3):353-6 [1782995] Brain Res. 1992 Jan 20;570(1-2):333-40 [1617424] Neuropharmacology. 1992 Dec;31(12):1201-10 [1361665] Neuropharmacology. 1992 Dec;31(12):1211-22 [1361666] Biol Psychiatry. 1993 Apr 1;33(7):520-5 [8513036] J Neurochem. 1993 Dec;61(6):2303-10 [8245981] Clin Pharmacol Ther. 1994 Jan;55(1):44-9 [8299315] Brain Res Mol Brain Res. 1993 Dec;20(4):289-98 [8114616] J Neurochem. 1994 Dec;63(6):2361-4 [7964759] Arch Gen Psychiatry. 1995 Jul;52(7):531-43 [7598629] Biol Psychiatry. 1996 Oct 1;40(7):568-75 [8886289] Curr Opin Cell Biol. 1997 Apr;9(2):161-7 [9069266] Synapse. 1997 Jul;26(3):281-91 [9183817] Am J Psychiatry. 1997 Jul;154(7):976-82 [9210749] J Pharmacol Exp Ther. 1997 Dec;283(3):1445-52 [9400020] J Pharmacol Exp Ther. 1998 Apr;285(1):307-16 [9536026] Exp Eye Res. 1998 Jul;67(1):45-52 [9702177] J Clin Psychopharmacol. 1998 Oct;18(5):404-13 [9790159] J Biol Chem. 1999 Apr 23;274(17):11447-50 [10206945] Neuroscience. 1999;91(2):771-6 [10366032] Biol Psychiatry. 1999 Jul 15;46(2):247-55 [10418700] J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62 [14399272] Arch Gen Psychiatry. 2005 Sep;62(9):996-1004 [16143731] Psychoneuroendocrinology. 2006 May;31(4):543-7 [16356651] Biol Psychiatry. 2006 Jun 1;59(11):1006-20 [16487491] Biol Psychiatry. 2006 Jun 15;59(12):1160-71 [16457783] Nature. 2007 Jun 7;447(7145):661-78 [17554300] Bipolar Disord. 2007 Sep;9(6):561-70 [17845270] Neuropsychobiology. 2007;55(3-4):123-31 [17641532] Bipolar Disord. 2000 Jun;2(2):108-19 [11252650] Bipolar Disord. 2000 Dec;2(4):305-15 [11252642] Mol Psychiatry. 2008 Feb;13(2):197-207 [17486107] Biol Psychiatry. 2001 Sep 1;50(5):364-70 [11543740] Curr Psychiatry Rep. 2001 Dec;3(6):451-62 [11707158] Biol Psychiatry. 2002 May 1;51(9):745-52 [11983188] Am J Obstet Gynecol. 2002 Dec;187(6):1711-2 [12501088] Neuropsychopharmacology. 2004 Apr;29(4):759-69 [14970832] Science. 2004 Oct 29;306(5697):882-4 [15514161] J Nerv Ment Dis. 1969 Jan;148(1):87-98 [5768895] Acta Psychiatr Scand. 1979 Apr;59(4):420-30 [433633] J Biol Chem. 1980 Nov 25;255(22):10896-901 [6253491] J Neurochem. 1981 Jun;36(6):1947-51 [6264039] Biochem J. 1982 Sep 15;206(3):587-95 [7150264] J Clin Pharmacol. 1986 Nov-Dec;26(8):717-9 [3793965] J Am Geriatr Soc. 1987 Feb;35(2):177-8 [3100605] J Clin Psychiatry. 1987 Sep;48(9):371-2 [3114243] Nature. 1988 Feb 4;331(6155):388 [3123995] Nature. 1988 Feb 4;331(6155):440-2 [3340189] Arch Gen Psychiatry. 1989 Jul;46(7):632-8 [2735813] J Clin Psychopharmacol. 1989 Dec;9(6):454-5 [2512332] Psychopharmacol Bull. 1991;27(1):17-22 [1862201] Biol Psychiatry. 1991 Sep 15;30(6):635-6 [1932412] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/j.1399-5618.2008.00636.x ER - TY - JOUR T1 - Revised assignment of absolute configuration of the cis- and trans-N6-deoxyadenosine adducts at C14 of (+/-)-11beta,12alpha-dihydroxy-13alpha,14alpha-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene by stereoselective synthesis. AN - 66716208; 19053320 AB - We have reassigned relative and absolute configurations by unambiguous stereoselective syntheses of the cis- (13s and 13R) and trans-N6-deoxyadenosine (dAdo) adduct diastereomers (14S and 14R) derived from (+/-)-11beta,12alpha-dihydroxy-13alpha,14alpha-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene (DB[a,l]P DE-2), previously reported by Li et al. [(1999) Chem. Res. Toxicol. 12, 758-767]. Two stereoselective methods, asymmetric aminohydroxylation of the (+/-)-trans-11,12-dihydrodiol (3) with 3',5'-di-O-(tert -butyldimethylsilyl)-2'-deoxyadenosine (4) and the highly stereoselective cis addition of 4 to (+/-)-DB[a,l]P DE-2 in hexafluoropropan-2-ol (HFP), were employed. Both afforded a 1:1 mixture of the cis-N6-dAdo adduct diastereomers, which were separated as triacetates (5S and 5R) in comparable yields (approximately 80%). The corresponding trans adduct diastereomers (10S and 10R) were obtained by coupling the aminotriol derived from trans opening of (+/-)-DB[a,l]P DE-2 with 6-fluoro-(2'-deoxy-3,5-di-tert-butyldimethylsilyloxy-beta-D-erythro-pentafuranosyl)purine (9) and subsequent acetylation in approximately 70% yield. The cis-5S and -5R and trans-10S and -10R were separately treated with 7% HF-pyridine followed by ammonolysis in NH3-saturated MeOH to give the dAdo adducts with all hydroxyl groups free (13S, 13R, 14S, and 14R). Comparison of the 1H NMR and CD spectra of these presently synthesized dAdo adducts with spectra of the previously reported compounds revealed that the interpretation of the 1H NMR and CD spectra and assignment of the relative stereochemistry (cis/trans) and absolute configuration made by Li et al. were at variance with our results. The above highly stereoselective syntheses of (+/-)-DB[a,l]P DE-2 adducted dAdo derivatives enabled efficient preparation of each of the four possible stereoisomeric 5'-dimethoxytrityl-3'-phosphoramidites for use in oligonucleotide synthesis. JF - Chemical research in toxicology AU - Yagi, Haruhiko AU - Frank, Heinrich AU - Seidel, Albrecht AU - Jerina, Donald M AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 2379 EP - 2392 VL - 21 IS - 12 SN - 0893-228X, 0893-228X KW - 11beta,12alpha-dihydroxy-13alpha,14alpha-epoxy-11,12,13,14-tetrahydrodibenzo(a,l)pyrene KW - 0 KW - Carcinogens KW - DNA Adducts KW - Deoxyadenosines KW - Dihydroxydihydrobenzopyrenes KW - Epoxy Compounds KW - Index Medicus KW - Stereoisomerism KW - Molecular Conformation KW - DNA Adducts -- chemistry KW - Carcinogens -- chemistry KW - Epoxy Compounds -- chemistry KW - Dihydroxydihydrobenzopyrenes -- chemistry KW - Deoxyadenosines -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66716208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Revised+assignment+of+absolute+configuration+of+the+cis-+and+trans-N6-deoxyadenosine+adducts+at+C14+of+%28%2B%2F-%29-11beta%2C12alpha-dihydroxy-13alpha%2C14alpha-epoxy-11%2C12%2C13%2C14-tetrahydrodibenzo%5Ba%2Cl%5Dpyrene+by+stereoselective+synthesis.&rft.au=Yagi%2C+Haruhiko%3BFrank%2C+Heinrich%3BSeidel%2C+Albrecht%3BJerina%2C+Donald+M&rft.aulast=Yagi&rft.aufirst=Haruhiko&rft.date=2008-12-01&rft.volume=21&rft.issue=12&rft.spage=2379&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx800268f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-21 N1 - Date created - 2009-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx800268f ER - TY - JOUR T1 - Host-environment interactions in exposure-related diffuse lung diseases. AN - 66689953; 19221958 AB - Diffuse lung disease (DLD), also known as interstitial lung disease (ILD), comprises a group of relatively rare but devastating lung diseases that involve varying degrees of acute and chronic inflammation, and which may present with end-stage fibroproliferation. There are currently no proven therapeutic strategies to halt progression of DLDs. Thinking about DLDs has evolved over time from hypotheses invoking inflammation as the prime mover in the etiology of disease, to the current hypothesis that interactions between a damaged and frustrated epithelium, and the response of underlying mesenchymal cells that takes place, contribute to the fibroproliferative milieu. The greatest challenge to understanding the role of environmental exposures in pathogenesis of DLDs is that there is no clear consensus on the etiology and pathogenesis of these diseases. Emerging data on the relationship between loss of epithelial integrity and mesenchymal fibroproliferation support the hypothesis that the damage to the epithelium is a critical component in the development of DLDs that progress to a fibroproliferative presentation. Thus it follows that environmental stress which impacts the well-being of the epithelium may play a critical role in shifting the balance of lung homeostasis through ongoing insult as a result of exposure to environmental agents. Animal models that recapitulate the vulnerable epithelium observed in patients who develop fibrotic lung disease associated with DLDs will provide the best opportunity to understand mechanisms associated with the etiology of these diseases. JF - Seminars in respiratory and critical care medicine AU - Brass, David M AU - Wise, Anastasia L AU - Schwartz, David A AD - National Heart Lung and Blood Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. David.brass@duke.edu Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 603 EP - 609 VL - 29 IS - 6 KW - Index Medicus KW - Animals KW - Humans KW - Disease Progression KW - Disease Models, Animal KW - Mesenchymal Stromal Cells -- metabolism KW - Epithelium -- pathology KW - Homeostasis -- drug effects KW - Epithelium -- drug effects KW - Pulmonary Fibrosis -- etiology KW - Pulmonary Fibrosis -- physiopathology KW - Lung Diseases, Interstitial -- etiology KW - Lung Diseases, Interstitial -- physiopathology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66689953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+respiratory+and+critical+care+medicine&rft.atitle=Host-environment+interactions+in+exposure-related+diffuse+lung+diseases.&rft.au=Brass%2C+David+M%3BWise%2C+Anastasia+L%3BSchwartz%2C+David+A&rft.aulast=Brass&rft.aufirst=David&rft.date=2008-12-01&rft.volume=29&rft.issue=6&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=Seminars+in+respiratory+and+critical+care+medicine&rft.issn=1098-9048&rft_id=info:doi/10.1055%2Fs-0028-1101270 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-25 N1 - Date created - 2009-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-0028-1101270 ER - TY - JOUR T1 - Striving for Control: Cognitive, Self-Care, and Faith Strategies Employed by Vulnerable Black and White Older Adults with Multiple Chronic Conditions AN - 61774796; 200921096 AB - The average older adult reaches age 65 with at least two chronic, co-occurring illnesses, or multiple morbidities (MM). We currently lack critical information about the specific strategies older adults use to attempt to control these MM. To increase our understanding of how older adults attempt to manage these MM and retain control of their health, in-depth interviews were conducted with 41 Black and White middle aged and older men and women with MM. We were particularly interested in representing the experience of those groups more vulnerable to adverse health outcomes due to greater disease prevalence and low income. During in-depth interviews, we asked open-ended questions on life and health history and open-ended and semi-structured questions about self-care for multiple morbidities. Participants expressed a strong desire to remain in control of their health; to do so they employed a wide range of strategies including cognitive structuring techniques (being health vigilant, normalizing, resignation/relinquishing control, and social comparison), self-care activities (emphasizing diet, exercise, medication taking, modifying existing activities, going to the doctor), and faith orientations (prayer as a constructive support strategy, gaining strength from God, church as a central part of life). With the exception of faith orientations, there were no race/ethnicity differences in the strategies participants use. Future studies should expand on this knowledge by exploring the contextual, cultural, and psychological backdrop and characteristics that shape the use of these coping strategies. Adapted from the source document. JF - Journal of Cross-Cultural Gerontology AU - Leach, Corinne R AU - Schoenberg, Nancy E AD - Cancer Prevention Fellow, National Cancer Institute and Master of Public Health Student, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA cleach@hsph.harvard.edu Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 377 EP - 399 PB - Springer, Dordrecht The Netherlands VL - 23 IS - 4 SN - 0169-3816, 0169-3816 KW - Self Care KW - Chronic Illness KW - Religiosity KW - Elderly KW - Health KW - Diseases KW - Coping KW - article KW - 2143: social problems and social welfare; social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61774796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Gerontology&rft.atitle=Striving+for+Control%3A+Cognitive%2C+Self-Care%2C+and+Faith+Strategies+Employed+by+Vulnerable+Black+and+White+Older+Adults+with+Multiple+Chronic+Conditions&rft.au=Leach%2C+Corinne+R%3BSchoenberg%2C+Nancy+E&rft.aulast=Leach&rft.aufirst=Corinne&rft.date=2008-12-01&rft.volume=23&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Gerontology&rft.issn=01693816&rft_id=info:doi/10.1007%2Fs10823-008-9086-2 LA - English DB - Sociological Abstracts N1 - Date revised - 2009-05-04 N1 - Number of references - 66 N1 - Last updated - 2016-09-28 N1 - CODEN - JCCGEB N1 - SubjectsTermNotLitGenreText - Chronic Illness; Elderly; Diseases; Health; Self Care; Coping; Religiosity DO - http://dx.doi.org/10.1007/s10823-008-9086-2 ER - TY - JOUR T1 - A tailored internet-plus-email intervention for increasing physical activity among ethnically-diverse women AN - 57304033; 200918490 AB - Objective To evaluate the feasibility and efficacy of an individually tailored, Internet-plus-email physical activity intervention designed for adult women. Method Healthy and ethnically-diverse adult females (N = 156) (mean age = 42.8 years, 65% Caucasian) from California were randomly assigned to an intervention (access to a tailored website and weekly emails) or wait-list control group. Participants completed web-based assessments of physical activity, stage of behavior change, and psychosocial variables at baseline, one month, two months, and three months. Data were collected during 2006 -2007. Multilevel random coefficient modeling examined group differences in rates of change. Results As compared to the control condition, the intervention group increased walking (+ 69 versus + 32 min per week) and total moderate-to-vigorous physical activity (+ 23 versus - 25 min per week) after three months. The intervention did not impact stage of behavior change or any of the other psychosocial variables. Conclusion A tailored, Internet-based intervention for adult women had a positive effect on walking and moderate-to-vigorous physical activity in an ethnically-diverse sample. However, given the lack of comparable research contact in the control group, these findings should be taken cautiously. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Dunton, Genevieve Fridlund AU - Robertson, Trina P AD - Health Promotion Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20852, USA Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 605 EP - 611 PB - Elsevier Ltd, The Netherlands VL - 47 IS - 6 SN - 0091-7435, 0091-7435 KW - Exercise Walking Intervention Internet Women Compliance KW - Web sites KW - Electronic mail systems KW - Physical activity KW - Behavioural changes KW - Women KW - Psychosocial factors KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57304033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=A+tailored+internet-plus-email+intervention+for+increasing+physical+activity+among+ethnically-diverse+women&rft.au=Dunton%2C+Genevieve+Fridlund%3BRobertson%2C+Trina+P&rft.aulast=Dunton&rft.aufirst=Genevieve&rft.date=2008-12-01&rft.volume=47&rft.issue=6&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2008.10.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Physical activity; Women; Behavioural changes; Psychosocial factors; Electronic mail systems; Web sites DO - http://dx.doi.org/10.1016/j.ypmed.2008.10.004 ER - TY - JOUR T1 - Nutrition-Related Cancer Prevention Cognitions and Behavioral Intentions: Testing the Risk Perception Attitude Framework AN - 57276723; 200904990 AB - This study tested whether the risk perception attitude framework predicted nutrition-related cancer prevention cognitions and behavioral intentions. Data from the 2003 Health Information National Trends Survey were analyzed to assess respondents'reported likelihood of developing cancer (risk) and perceptions of whether they could lower their chances of getting cancer (efficacy). Respondents with higher efficacy were more likely to report that good nutrition can prevent cancer, and they reported more preventive dietary changes, as compared to respondents with lower efficacy. Respondents with higher efficacy were more likely to report intentions to change their diets to prevent cancer, and they reported more preventive dietary changes to their own diets but only at higher levels of risk. Results suggest that to improve cognitions about the role of nutrition in cancer prevention, interventions should target cancer prevention efficacy; however, to increase intentions to change nutrition behaviors, interventions should target efficacy and risk perceptions. [Reprinted by permission of Sage Publications Inc., copyright 2008, Society for Public Health Education.] JF - Health Education & Behavior AU - Sullivan, Helen W AU - Beckjord, Ellen Burke AU - Rutten, Lila J Finney AU - Hesse, Bradford W AD - National Cancer Institute, Bethesda, Maryland Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 866 EP - 879 PB - Sage Publications, Thousand Oaks CA VL - 35 IS - 6 SN - 1090-1981, 1090-1981 KW - risk perception attitude framework KW - Health Information National Trends Survey KW - cancer prevention KW - Preventive strategies KW - Health beliefs KW - Intention KW - Risk perception KW - Cancer KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57276723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Nutrition-Related+Cancer+Prevention+Cognitions+and+Behavioral+Intentions%3A+Testing+the+Risk+Perception+Attitude+Framework&rft.au=Sullivan%2C+Helen+W%3BBeckjord%2C+Ellen+Burke%3BRutten%2C+Lila+J+Finney%3BHesse%2C+Bradford+W&rft.aulast=Sullivan&rft.aufirst=Helen&rft.date=2008-12-01&rft.volume=35&rft.issue=6&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198108326164 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Cancer; Health beliefs; Risk perception; Preventive strategies; Health behaviour; Intention DO - http://dx.doi.org/10.1177/1090198108326164 ER - TY - JOUR T1 - Risk for Bipolar Disorder Is Associated With Face-Processing Deficits Across Emotions AN - 57272391; 200901234 AB - Objective: Youths with euthymic bipolar disorder (BD) have a deficit in face-emotion labeling that is present across multiple emotions. Recent research indicates that youths at familial risk for BD, but without a history of mood disorder, also have a deficit in face-emotion labeling, suggesting that such impairments may be an endophenotype for BD. It is unclear whether this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest. Method: Thirty-seven patients with pediatric BD, 25 unaffected children with a first-degree relative with BD, and 36 typically developing youths were administered the Emotional Expression Multimorph Task, a computerized behavioral task, which presents gradations of facial emotions from 100% neutrality to 100% emotional expression (happiness, surprise, fear, sadness, anger, and disgust). Results: Repeats d measures analysis of covariance revealed that, compared with the control youths, the patients and the at-risk youths required significantly more intense emotional information to identify and correctly label face emotions. The patients with BD and the at-risk youths did not differ from each other. Group-by-emotion interactions were not significant, indicating that the group effects did not differ based on the facial emotion. Conclusions: The youths at risk for BD demonstrate nonspecific deficits in face-emotion recognition, similar to patients with the illness. Further research is needed to determine whether such deficits meet all the criteria for an endophenotype. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Brotman, Melissa A AU - Skup, Martha AU - Rich, Brendan A AU - Blair, Karina S AU - Pine, Daniel S AU - Blair, James R AU - Leibenluft, Ellen AD - 15K North Drive, Room 208, Bethesda, MD 20892 brotmanm@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1455 EP - 1461 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 12 SN - 0890-8567, 0890-8567 KW - bipolar disorder, endophenotype, face emotion labeling, at risk KW - Paediatrics KW - Emotions KW - Bipolar affective disorder KW - Young people KW - Phenotypes KW - At risk KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57272391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Risk+for+Bipolar+Disorder+Is+Associated+With+Face-Processing+Deficits+Across+Emotions&rft.au=Brotman%2C+Melissa+A%3BSkup%2C+Martha%3BRich%2C+Brendan+A%3BBlair%2C+Karina+S%3BPine%2C+Daniel+S%3BBlair%2C+James+R%3BLeibenluft%2C+Ellen&rft.aulast=Brotman&rft.aufirst=Melissa&rft.date=2008-12-01&rft.volume=47&rft.issue=12&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e318188832e LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Young people; Emotions; At risk; Bipolar affective disorder; Paediatrics; Phenotypes DO - http://dx.doi.org/10.1097/CHI.0b013e318188832e ER - TY - JOUR T1 - Recent NIMH Clinical Trials and Implications for Practice AN - 57264986; 200902755 AB - More than 10 years ago, the National Institute of Mental Health (NIMH) started a program of multisite clinical trials with the purpose of providing clinicians, patients, and families with the scientific evidence necessary for making informed treatment decisions in child and adolescent psychiatry.1 The focus was on treatments already used in clinical practice but without adequate evidence of efficacy and safety. The specific aim of each trial varied according to the state of the science of the disorder being treated and the particular treatment being tested. Thus, for medications in need of efficacy evaluation, and often used off-label in the community, as was the case for the selective serotonin reuptake inhibitor (SSRI) antidepressants in pediatric anxiety disorders or for the second-generation antipsychotics in autism, straightforward placebo-controlled trials were conducted.2,3 When efficacy had been demonstrated, however, trials were launched to directly compare the relative benefits of active treatments and to assess the possible advantage of combined treatment versus monotherapy. The main findings of NIMH-funded, multisite, randomized clinical trials completed in the last 5 years are here briefly reviewed, and their implications for practice are discussed (Table 1). Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Vitiello, Benedetto AD - National Institute of Mental Health, Room 7147, 6001 Executive Blvd., Bethesda, MD 20892-9633 bvitiell@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1369 EP - 1374 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 12 SN - 0890-8567, 0890-8567 KW - Paediatrics KW - Efficacy KW - Antidepressant drugs KW - Psychiatry KW - Clinical trials KW - Treatment needs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57264986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Recent+NIMH+Clinical+Trials+and+Implications+for+Practice&rft.au=Vitiello%2C+Benedetto&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2008-12-01&rft.volume=47&rft.issue=12&rft.spage=1369&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e31818960a7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Efficacy; Antidepressant drugs; Clinical trials; Treatment needs; Paediatrics; Psychiatry DO - http://dx.doi.org/10.1097/CHI.0b013e31818960a7 ER - TY - JOUR T1 - Methylphenidate and Amphetamine Do Not Induce Cytogenetic Damage in Lymphocytes of Children With ADHD AN - 57249227; 200902837 AB - Objective: In response to previously published findings of methylphenidate-induced chromosomal changes in children, this study was designed to determine whether methylphenidate- or amphetamine-based drugs induce chromosomal damage (structural aberrations, micronuclei, and sister chromatid exchanges) in peripheral blood lymphocytes of children with attention-deficit/hyperactivity disorder after 3 months of continuous treatment. Method: Stimulant drug-naive subjects, 6 to 12 years of age, in good overall health, and judged to be appropriate candidates for stimulant therapy based on rigorously diagnosed ADHD using DSM-IV criteria, were randomized into two open-label treatment groups (methylphenidate or mixed amphetamine salts). Each subject provided a blood sample before initiation of treatment and after 3 months of treatment. Pretreatment and posttreatment frequencies of chromosomal aberrations, micronuclei, and sister chromatid exchanges were determined for each subject. Results: Sixty-three subjects enrolled in the study; 47 subjects completed the full 3 months of treatment, 25 in the methylphenidate group and 22 in the amphetamine group. No significant treatment-related increases were observed in any of the three measures of cytogenetic damage in the 47 subjects who completed treatment or the 16 subjects who did not. Conclusions: Earlier findings of methylphenidate-induced chromosomal changes in children were not replicated in this study. These results add to the accumulating evidence that therapeutic levels of methylphenidate do not induce cytogenetic damage in humans. Furthermore, our results indicate that amphetamine-based products do not pose a risk for cytogenetic damage in children. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Witt, Kristine L AU - Shelby, Michael D AU - Itchon-Ramos, Nilda AU - Faircloth, Melissa AU - Kissling, Grace E AU - Chrisman, Allan K AU - Ravi, Hima AU - Murli, Hemalatha AU - Mattison, Donald R AU - Kollins, Scott H AD - National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop EC-32, 79 TW Alexander Drive, Suite 100, Room 159A, Research Triangle Park, NC 27709 witt@niehs.nih.gov Y1 - 2008/12// PY - 2008 DA - December 2008 SP - 1375 EP - 1383 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 12 SN - 0890-8567, 0890-8567 KW - stimulant drugs, micronuclei, chromosome aberrations, sister chromatid exchanges, cohort study, Clinical trial registration information, Genetic Measurements in Blood Cells of Children Taking Adderall or Methylphenidate KW - Amphetamines KW - Immunology KW - Attention deficit hyperactivity disorder KW - Methylphenidate KW - Children KW - Side effects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57249227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Methylphenidate+and+Amphetamine+Do+Not+Induce+Cytogenetic+Damage+in+Lymphocytes+of+Children+With+ADHD&rft.au=Witt%2C+Kristine+L%3BShelby%2C+Michael+D%3BItchon-Ramos%2C+Nilda%3BFaircloth%2C+Melissa%3BKissling%2C+Grace+E%3BChrisman%2C+Allan+K%3BRavi%2C+Hima%3BMurli%2C+Hemalatha%3BMattison%2C+Donald+R%3BKollins%2C+Scott+H&rft.aulast=Witt&rft.aufirst=Kristine&rft.date=2008-12-01&rft.volume=47&rft.issue=12&rft.spage=1375&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e3181893620 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Children; Methylphenidate; Amphetamines; Attention deficit hyperactivity disorder; Side effects; Immunology DO - http://dx.doi.org/10.1097/CHI.0b013e3181893620 ER - TY - JOUR T1 - Systematic review of public health branding AN - 37021417; 3805627 AB - Brands build relationships between consumers and products, services, or lifestyles by providing beneficial exchanges and adding value to their objects. Brands can be measured through associations that consumers hold for products and services. Public health brands are the associations that individuals hold for health behaviors, or lifestyles that embody multiple health behaviors. We systematically reviewed the literature on public health brands; developed a methodology for describing branded health messages and campaigns; and examined specific branding strategies across a range of topic areas, campaigns, and global settings. We searched the literature for published studies on public health branding available through all relevant, major online publication databases. Public health branding was operationalized as any manuscripts in the health, social science, and business literature on branding or brands in health promotion marketing. We developed formalized decision rules and applied them in identifying articles for review. We initially identified 154 articles and reviewed a final set of 37, 10 from Africa, Australia, and Europe. Branded health campaigns spanned most of the major domains of public health and numerous communication strategies and evaluation methodologies. Most studies provided clear information on planning, development, and evaluation of the branding effort, while some provided minimal information. Branded health messages typically are theory based, and there is a body of evidence on their behavior change effectiveness, especially in nutrition, tobacco control, and HIV/AIDS. More rigorous research is needed, however, on how branded health messages impact specific populations and behaviors. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Evans, W Douglas AU - Blitstein, Jonathan AU - Hersey, James AU - Renaud, Jeanette AU - Yaroch, Amy AD - Research Triangle Institute International ; National Cancer Institute Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 721 EP - 741 VL - 13 IS - 8 SN - 1081-0730, 1081-0730 KW - Economics KW - Sociology KW - Medical research KW - AIDS KW - Marketing KW - Diseases KW - HIV KW - Information dissemination KW - Illness KW - Brands KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37021417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Systematic+review+of+public+health+branding&rft.au=Evans%2C+W+Douglas%3BBlitstein%2C+Jonathan%3BHersey%2C+James%3BRenaud%2C+Jeanette%3BYaroch%2C+Amy&rft.aulast=Evans&rft.aufirst=W&rft.date=2008-12-01&rft.volume=13&rft.issue=8&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730802487364 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10449 5772; 1757 7738 11245 11239; 7738 11245 11239; 6520; 5703 3617 6220; 482 3617 6220; 7886 10902; 6220; 3617 6220 DO - http://dx.doi.org/10.1080/10810730802487364 ER - TY - JOUR T1 - Occupational practices and the making of health news: a national survey of U.S. health and medical science journalists AN - 37021029; 3805629 AB - News media coverage of health topics can frame and heighten the salience of health-related issues, thus influencing the public's beliefs, attitudes, and behaviors. Through their routine coverage of scientific developments, news media are a critical intermediary in translating research for the public, patients, practitioners, and policymakers. Until now, little was known about how health and medical science reporters and editors initiate, prioritize, and develop news stories related to health and medicine. We surveyed 468 reporters and editors representing 463 local and national broadcast and print media outlets to characterize individual characteristics and occupational practices leading to the development of health and medical science news. Our survey revealed that 70% of respondents had bachelor's degrees; 8% were life sciences majors in college. Minorities are underrepresented in health journalism; 97% of respondents were non-Hispanic and 93% were White. Overall, initial ideas for stories come from a "news source" followed by press conferences or press releases. Regarding newsworthiness criteria, the "potential for public impact" and "new information or development" are the major criteria cited, followed by "ability to provide a human angle" and "ability to provide a local angle." Significant differences were seen between responses from reporters vs. editors and print vs. broadcast outlets. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Viswanath, K AU - Blake, Kelly AU - Meissner, Helen AU - Saiontz, Nicole Gottlieb AU - Mull, Corey AU - Freeman, Carol AU - Hesse, Bradford AU - Croyle, Robert AD - Harvard University ; National Institutes of Health ; National Cancer Institute ; ORC Macro International Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 759 EP - 777 VL - 13 IS - 8 SN - 1081-0730, 1081-0730 KW - Sociology KW - Media KW - Minorities KW - Survey data KW - U.S.A. KW - Information dissemination KW - News KW - Press releases KW - Journalism KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37021029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Occupational+practices+and+the+making+of+health+news%3A+a+national+survey+of+U.S.+health+and+medical+science+journalists&rft.au=Viswanath%2C+K%3BBlake%2C+Kelly%3BMeissner%2C+Helen%3BSaiontz%2C+Nicole+Gottlieb%3BMull%2C+Corey%3BFreeman%2C+Carol%3BHesse%2C+Bradford%3BCroyle%2C+Robert&rft.aulast=Viswanath&rft.aufirst=K&rft.date=2008-12-01&rft.volume=13&rft.issue=8&rft.spage=759&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730802487430 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10449 5772; 12427 12429; 10067; 8122; 8669 6515; 6520; 6999; 7862 2572; 433 293 14 DO - http://dx.doi.org/10.1080/10810730802487430 ER - TY - JOUR T1 - Semiparametric two-sample changepoint model with application to human immunodeficiency virus studies AN - 37006353; 3793384 AB - A two-sample changepoint model is proposed to investigate the difference between two treatments or devices. Under our semiparametric approach, no assumptions are made about the underlying distributions of the measurements from the two treatments or devices, but a parametric link is assumed between the two. The parametric link contains the possible changepoint where the two distributions start to differ. We apply the maximum empirical likelihood for model estimation and show the consistency of the changepoint estimator. An extended changepoint model is studied to handle data censored because of detection limits in viral load assays of human immunodeficiency virus (HIV). Permutation and bootstrap procedures are proposed to test the existence of a changepoint and the goodness of fit of the model. The performance of the semiparametric changepoint model is compared with that of parametric models in a simulation study. We provide two applications in HIV studies: one is a randomized placebo-controlled study to evaluated the effects of a recombinant glycoprotein 120 vaccine on HIV viral load; the other is a study to compare two types of tubes in handling plasma samples for viral load determination. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Hu, Z. AU - Qin, J AU - Follmann, D AD - National Institute of Allergy and Infectious Diseases Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 589 EP - 608 VL - 57 IS - 5 SN - 0035-9254, 0035-9254 KW - Sociology KW - Statistics KW - Medical research KW - Distribution KW - Maximum likelihood method KW - HIV KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37006353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Semiparametric+two-sample+changepoint+model+with+application+to+human+immunodeficiency+virus+studies&rft.au=Hu%2C+Z.%3BQin%2C+J%3BFollmann%2C+D&rft.aulast=Hu&rft.aufirst=Z.&rft.date=2008-12-01&rft.volume=57&rft.issue=5&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12233; 12228 10919; 7886 10902; 7837 8160 8163 12230; 5703 3617 6220; 3641 12233 ER - TY - JOUR T1 - The Early Phagosomal Stage of Francisella tularensis Determines Optimal Phagosomal Escape and Francisella Pathogenicity Island Protein Expression AN - 21508609; 12495322 AB - Francisella tularensis is an intracellular pathogen that can survive and replicate within macrophages. Following phagocytosis and transient interactions with the endocytic pathway, F. tularensis rapidly escapes from its original phagosome into the macrophage cytoplasm, where it eventually replicates. To examine the importance of the nascent phagosome for the Francisella intracellular cycle, we have characterized early trafficking events of the F. tularensis subsp. tularensis strain Schu S4 in a murine bone marrow-derived macrophage model. Here we show that early phagosomes containing Schu S4 transiently interact with early and late endosomes and become acidified before the onset of phagosomal disruption. Inhibition of endosomal acidification with the vacuolar ATPase inhibitor bafilomycin A1 or concanamycin A prior to infection significantly delayed but did not block phagosomal escape and cytosolic replication, indicating that maturation of the early Francisella-containing phagosome (FCP) is important for optimal phagosomal escape and subsequent intracellular growth. Further, Francisella pathogenicity island (FPI) protein expression was induced during early intracellular trafficking events. Although inhibition of endosomal acidification mimicked the early phagosomal escape defects caused by mutation of the FPI-encoded IglCD proteins, it did not inhibit the intracellular induction of FPI proteins, demonstrating that this response is independent of phagosomal pH. Altogether, these results demonstrate that early phagosomal maturation is required for optimal phagosomal escape and that the early FCP provides cues other than intravacuolar pH that determine intracellular induction of FPI proteins. JF - Infection and Immunity AU - Chong, Audrey AU - Wehrly, Tara D AU - Nair, Vinod AU - Fischer, Elizabeth R AU - Barker, Jeffrey R AU - Klose, Karl E AU - Celli, Jean AD - Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, jcelli@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 5488 EP - 5499 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 12 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Adenosinetriphosphatase KW - Replication KW - Concanamycin A KW - Phagosomes KW - Animal models KW - Bone marrow KW - Francisella tularensis KW - Pathogens KW - Infection KW - pathogenicity islands KW - endosomes KW - Cytoplasm KW - Acidification KW - Phagocytosis KW - pH effects KW - Mutation KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21508609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Early+Phagosomal+Stage+of+Francisella+tularensis+Determines+Optimal+Phagosomal+Escape+and+Francisella+Pathogenicity+Island+Protein+Expression&rft.au=Chong%2C+Audrey%3BWehrly%2C+Tara+D%3BNair%2C+Vinod%3BFischer%2C+Elizabeth+R%3BBarker%2C+Jeffrey+R%3BKlose%2C+Karl+E%3BCelli%2C+Jean&rft.aulast=Chong&rft.aufirst=Audrey&rft.date=2008-12-01&rft.volume=76&rft.issue=12&rft.spage=5488&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00682-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Macrophages; Adenosinetriphosphatase; Replication; Concanamycin A; Phagosomes; Bone marrow; Animal models; Pathogens; Infection; pathogenicity islands; endosomes; Cytoplasm; Acidification; Phagocytosis; Mutation; pH effects; Francisella tularensis DO - http://dx.doi.org/10.1128/IAI.00682-08 ER - TY - JOUR T1 - Benefit in phase 1 oncology trials: therapeutic misconception or reasonable treatment option? AN - 21342690; 9398754 AB - Novel treatments for cancer are tested initially in phase 1 trials enrolling patients with advanced disease who have exhausted standard treatment options. Although these trials are designed to evaluate safety and to define dosing for future efficacy trials, most patients volunteer with the hope of obtaining medical benefit. Do phase 1 oncology trials promote a `therapeutic misconception' among eligible patients about the personal meaning of trial participation, or do they offer them a reasonable prospect of direct medical benefit as compared with available alternatives? Recent evidence on outcomes of phase 1 oncology trials is examined systematically, with the aim of accurately assessing the prospect of direct medical benefit for participants and drawing implications for informed consent. We argue that, in view of important uncertainties, aggregate data from phase 1 trials relating to the surrogate outcomes of tumor shrinkage and stable disease do not permit any definitive estimate of a `clinical benefit rate.' Nevertheless, these trials do offer participants a prospect of direct medical benefit. As a result, accurately informed patients may reasonably decide to enroll in phase 1 oncology trials in hopes of obtaining benefit, after considering the anticipated risks and available clinical alternatives. Motivation to enroll in these studies to receive personal benefit does not, in itself, compromise informed consent. JF - Clinical Trials AU - Miller, Franklin G AU - Joffe, Steven AD - Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892-1156, USA, fmiller@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 617 EP - 623 PB - Sage Publications Ltd., 6 Bonhill St. VL - 5 IS - 6 SN - 1740-7745, 1740-7745 KW - Health & Safety Science Abstracts; Risk Abstracts KW - tumors KW - clinical trials KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21342690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Benefit+in+phase+1+oncology+trials%3A+therapeutic+misconception+or+reasonable+treatment+option%3F&rft.au=Miller%2C+Franklin+G%3BJoffe%2C+Steven&rft.aulast=Miller&rft.aufirst=Franklin&rft.date=2008-12-01&rft.volume=5&rft.issue=6&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774508097576 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - tumors; clinical trials; Cancer DO - http://dx.doi.org/10.1177/1740774508097576 ER - TY - JOUR T1 - Human tumor-associated viruses and new insights into the molecular mechanisms of cancer AN - 21309623; 11937531 AB - The study of acute-transforming retroviruses and their oncogenes and of the multiple mechanisms deployed by DNA viruses to circumvent the growth-suppressive and proapoptotic function of tumor suppressor genes has provided the foundation of our current understanding of cancer biology. Unlike acute-transforming animal viruses, however, human tumor-associated viruses lead to malignancies with a prolonged latency and in conjunction with other environmental and host-related cooperating events. The relevance of viral infection to human cancer development has often been debated. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Hence, the opportunity exists to fight cancer at the global scale by preventing the spread of these viruses, by the development and distribution of effective and safe antiviral vaccines, and by identifying their oncogenic mechanism. Here, we discuss the molecular events underlying the neoplastic potential of the human tumor-associated viruses, with emphasis on the enigmatic KSHV and its numerous virally hijacked proangiogenic, immune-evasive and tumor-promoting genes. The emerging information may facilitate the development of new molecular-targeted approaches to prevent and treat virally associated human malignancies. JF - Oncogene AU - Martin, D AU - Gutkind, J S AD - Cell Growth Regulation Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - S31 EP - S42 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 27 IS - S2 SN - 0950-9232, 0950-9232 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Oncogenes & Growth Factors Abstracts KW - Human T-lymphotropic virus KW - Molecular modelling KW - Tumor suppressor genes KW - Apoptosis KW - Hepatitis B virus KW - Human T-lymphotropic virus 1 KW - Kaposi's sarcoma-associated herpesvirus KW - Infection KW - DNA viruses KW - Epstein-Barr virus KW - Malignancy KW - Retrovirus KW - Oncogenes KW - Hepatitis C virus KW - Lymphocytes T KW - Sarcoma KW - Vaccines KW - Human papillomavirus KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - B 26650:Viral Oncogenes KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21309623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Human+tumor-associated+viruses+and+new+insights+into+the+molecular+mechanisms+of+cancer&rft.au=Martin%2C+D%3BGutkind%2C+J+S&rft.aulast=Martin&rft.aufirst=D&rft.date=2008-12-01&rft.volume=27&rft.issue=S2&rft.spage=S31&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fonc.2009.351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Molecular modelling; Malignancy; Apoptosis; Oncogenes; Sarcoma; Lymphocytes T; Vaccines; Infection; DNA viruses; Human T-lymphotropic virus; Epstein-Barr virus; Retrovirus; Hepatitis C virus; Hepatitis B virus; Human T-lymphotropic virus 1; Kaposi's sarcoma-associated herpesvirus; Human papillomavirus DO - http://dx.doi.org/10.1038/onc.2009.351 ER - TY - JOUR T1 - Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists AN - 21139120; 9355960 AB - Exposure to ionizing radiation has been consistently associated with increased risk of female breast cancer. Although the majority of DNA damage caused by ionizing radiation is corrected by the base-excision repair pathway, certain types of multiple-base damage can only be repaired through the nucleotide excision repair pathway. In a nested case-control study of breast cancer in US radiologic technologists exposed to low levels of ionizing radiation (858 cases, 1,083 controls), we examined whether risk of breast cancer conferred by radiation was modified by nucleotide excision gene polymorphisms ERCC2 (XPD) rs13181, ERCC4 (XPF) rs1800067 and rs1800124, ERCC5 (XPG) rs1047769 and rs17655; and ERCC6 rs2228526. Of the 6 ERCC variants examined, only ERCC5 rs17655 showed a borderline main effect association with breast cancer risk (ORGC = 1.1, ORCC = 1.3; p-trend = 0.08), with some indication that individuals carrying the C allele variant were more susceptible to the effects of occupational radiation (EOR/GyGG = 1.0, 95% CI = <0, 6.0; EOR/GyGC/CC = 5.9, 95% CI = 0.9, 14.4; phet = 0.10). ERCC2 rs13181, although not associated with breast cancer risk overall, statistically significantly modified the effect of occupational radiation dose on risk of breast cancer (EOR/GyAA = 9.1, 95% CI = 2.1-21.3; EOR/GyAC/CC = 0.6, 95% CI = <0, 4.6; phet = 0.01). These results suggest that common variants in nucleotide excision repair genes may modify the association between occupational radiation exposure and breast cancer risk. JF - International Journal of Cancer AU - Rajaraman, Preetha AU - Bhatti, Parveen AU - Doody, Michele Morin AU - Simon, Steven L AU - Weinstock, Robert M AU - Linet, Martha S AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Alexander, Bruce H AU - Preston, Dale L AU - Sigurdson, Alice J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, rajarama@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2713 EP - 2716 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 11 SN - 0020-7136, 0020-7136 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts KW - XPD protein KW - Gene polymorphism KW - Cancer KW - Nucleotides KW - DNA damage KW - USA KW - Nucleotide excision repair KW - Ionizing radiation KW - DNA KW - Breast cancer KW - Occupational exposure KW - X 24390:Radioactive Materials KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21139120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Nucleotide+excision+repair+polymorphisms+may+modify+ionizing+radiation-related+breast+cancer+risk+in+US+radiologic+technologists&rft.au=Rajaraman%2C+Preetha%3BBhatti%2C+Parveen%3BDoody%2C+Michele+Morin%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BLinet%2C+Martha+S%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BAlexander%2C+Bruce+H%3BPreston%2C+Dale+L%3BSigurdson%2C+Alice+J&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2008-12-01&rft.volume=123&rft.issue=11&rft.spage=2713&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23779 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - DNA damage; XPD protein; Nucleotide excision repair; Gene polymorphism; Ionizing radiation; Breast cancer; Nucleotides; Occupational exposure; DNA; Cancer; USA DO - http://dx.doi.org/10.1002/ijc.23779 ER - TY - JOUR T1 - Three-dimensional water diffusion in impermeable cylindrical tubes: theory versus experiments AN - 21069520; 8632367 AB - Characterizing diffusion of gases and liquids within pores is important in understanding numerous transport processes and affects a wide range of practical applications. Previous measurements of the pulsed gradient stimulated echo (PGSTE) signal attenuation, E(q), of water within nerves and impermeable cylindrical microcapillary tubes showed it to be exquisitely sensitive to the orientation of the applied wave vector, q, with respect to the tube axis in the high-q regime. Here, we provide a simple three-dimensional model to explain this angular dependence by decomposing the average propagator, which describes the net displacement of water molecules, into components parallel and perpendicular to the tube wall, in which axial diffusion is free and radial diffusion is restricted. The model faithfully predicts the experimental data, not only the observed diffraction peaks in E(q) when the diffusion gradients are approximately normal to the tube wall, but their sudden disappearance when the gradient orientation possesses a small axial component. The model also successfully predicts the dependence of E(q) on gradient pulse duration and on gradient strength as well as tube inner diameter. To account for the deviation from the narrow pulse approximation in the PGSTE sequence, we use Callaghan's matrix operator framework, which this study validates experimentally for the first time. We also show how to combine average propagators derived for classical one-dimensional and two-dimensional models of restricted diffusion (e.g. between plates, within cylinders) to construct composite three-dimensional models of diffusion in complex media containing pores (e.g. rectangular prisms and/or capped cylinders) having a distribution of orientations, sizes, and aspect ratios. This three-dimensional modeling framework should aid in describing diffusion in numerous biological systems and in a myriad of materials sciences applications. JF - NMR in Biomedicine AU - Avram, Liat AU - Ozarslan, Evren AU - Assaf, Yaniv AU - Bar-Shir, Amnon AU - Cohen, Yoram AU - Basser, Peter J AD - School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, Israel, pjbasser@helix.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 888 EP - 898 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 21 IS - 8 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Nerves KW - Molecular modelling KW - Pores KW - Gases KW - Data processing KW - Media (transport) KW - Waves KW - N.M.R. KW - Diffusion KW - Diffraction KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21069520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Three-dimensional+water+diffusion+in+impermeable+cylindrical+tubes%3A+theory+versus+experiments&rft.au=Avram%2C+Liat%3BOzarslan%2C+Evren%3BAssaf%2C+Yaniv%3BBar-Shir%2C+Amnon%3BCohen%2C+Yoram%3BBasser%2C+Peter+J&rft.aulast=Avram&rft.aufirst=Liat&rft.date=2008-12-01&rft.volume=21&rft.issue=8&rft.spage=888&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1277 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diffusion; Models; Pores; Diffraction; Data processing; Molecular modelling; Gases; N.M.R.; Waves; Media (transport); Nerves DO - http://dx.doi.org/10.1002/nbm.1277 ER - TY - JOUR T1 - Chronic granulomatous disease as a risk factor for autoimmune disease AN - 20736417; 8840527 AB - Chronic granulomatous disease (CGD) is characterized by recurrent infections and granuloma formation. In addition, we have observed a number of diverse autoimmune conditions in our CGD population, suggesting that patients with CGD are at an elevated risk for development of autoimmune disorders. In this report, we describe antiphospholipid syndrome, recurrent pericardial effusion, juvenile idiopathic arthritis, IgA nephropathy, cutaneous lupus erythematosus, and autoimmune pulmonary disease in the setting of CGD. The presence and type of autoimmune disease have important treatment implications for patients with CGD. JF - Journal of Allergy and Clinical Immunology AU - De Ravin, Suk See AU - Naumann, Nora AU - Cowen, Edward W AU - Friend, Julia AU - Hilligoss, Dianne AU - Np, Martha Marquesen AU - Balow, James E AU - Barron, Karyl S AU - Turner, Maria L AU - Gallin, John I AU - Malech, Harry L AD - National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md, sderavin@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1097 EP - 1103 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA, [mailto:membership@aaaai.org], [URL:http://www.aaai.org] VL - 122 IS - 6 SN - 0091-6749, 0091-6749 KW - Risk Abstracts; Immunology Abstracts KW - Cutaneous Lupus Erythematosus KW - Immunology KW - Autoimmune diseases KW - Lung diseases KW - autoimmune diseases KW - Effusion KW - Granuloma KW - Allergies KW - Arthritis KW - Risk factors KW - infection KW - Recurrent infection KW - IgA nephropathy KW - antiphospholipid syndrome KW - Chronic granulomatous disease KW - F 06925:Hypersensitivity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20736417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Chronic+granulomatous+disease+as+a+risk+factor+for+autoimmune+disease&rft.au=De+Ravin%2C+Suk+See%3BNaumann%2C+Nora%3BCowen%2C+Edward+W%3BFriend%2C+Julia%3BHilligoss%2C+Dianne%3BNp%2C+Martha+Marquesen%3BBalow%2C+James+E%3BBarron%2C+Karyl+S%3BTurner%2C+Maria+L%3BGallin%2C+John+I%3BMalech%2C+Harry+L&rft.aulast=De+Ravin&rft.aufirst=Suk&rft.date=2008-12-01&rft.volume=122&rft.issue=6&rft.spage=1097&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2008.07.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - autoimmune diseases; infection; Immunology; Allergies; Autoimmune diseases; Chronic granulomatous disease; antiphospholipid syndrome; Cutaneous Lupus Erythematosus; Granuloma; Recurrent infection; Risk factors; Effusion; IgA nephropathy; Lung diseases; Arthritis DO - http://dx.doi.org/10.1016/j.jaci.2008.07.050 ER - TY - JOUR T1 - Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 20731782; 8930912 AB - Objective: A history of diabetes has been fairly consistently related to a reduced prostate cancer risk, but previous investigations have not always addressed whether the relation with diabetes varies by prostate cancer aggressiveness or the association between diabetes and prostate cancer is modified by physical activity level and body mass, variables closely related to glucose metabolism. Methods: We prospectively examined the diabetes-prostate cancer risk relationship among 33,088 men in the screening arm of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Results: During 8.9 years follow-up, we ascertained 2,058 incident prostate cancer cases. Diabetes history was related to decreased risk of total prostate cancer (RR = 0.80, 95% CI = 0.68-0.95). The apparent protection afforded by diabetes was primarily due to the inverse relation with non-aggressive disease (i.e., the combination of low grade (Gleason sum [Lt]8) and low stage (clinical stages I or II); RR = 0.75; 95% CI = 0.62-0.91). In contrast, no association was noted between diabetes and aggressive disease (i.e., high grade or high stage (Gleason sum greater than or equal to 8 or clinical stages III or IV); RR = 1.04, 95% CI = 0.74-1.45). In further analyses, the association between diabetes and aggressive prostate cancer was suggestively positive for men who were lean (RR = 1.64, 95% CI = 0.87-3.07; BMI [Lt] 25 kg/m2) and it was positive for men who were the most physically active (RR = 1.63; 95% CI = 1.07-2.62; 3+ hours vigorous activity/week). By comparison, no relations of diabetes to aggressive prostate cancer were noted for their heavier or physically less active counterparts (p-value for tests of interaction = 0.10 and 0.03 BMI and physical activity, respectively). Conclusion: In this study, diabetes showed divergent relations with prostate cancer by tumor aggressiveness. Specifically, diabetes was inversely associated with early stage prostate cancer but it showed no relation with aggressive prostate cancer. Exploratory analyses suggested a positive association between diabetes and aggressive prostate cancer in the subgroup of men with a low BMI. JF - Cancer Causes & Control AU - Leitzmann, Michael F AU - Ahn, Jiyoung AU - Albanes, Demetrius AU - Hsing, Ann W AU - Schatzkin, Arthur AU - Chang, Shih-Chen AU - Huang, Wen-Yi AU - Weiss, Jocelyn M AU - Danforth, Kim N AU - Grubb, Robert L AU - Andriole, Gerald L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd., Bethesda, MD, 20892, USA, leitzmann@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1267 EP - 1276 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 19 IS - 10 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Historical account KW - diabetes mellitus KW - Lung KW - body mass KW - ovarian carcinoma KW - tumors KW - prostate cancer KW - aggressive behavior KW - physical activity KW - Cancer KW - Metabolism KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20731782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Diabetes+mellitus+and+prostate+cancer+risk+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Leitzmann%2C+Michael+F%3BAhn%2C+Jiyoung%3BAlbanes%2C+Demetrius%3BHsing%2C+Ann+W%3BSchatzkin%2C+Arthur%3BChang%2C+Shih-Chen%3BHuang%2C+Wen-Yi%3BWeiss%2C+Jocelyn+M%3BDanforth%2C+Kim+N%3BGrubb%2C+Robert+L%3BAndriole%2C+Gerald+L&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2008-12-01&rft.volume=19&rft.issue=10&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-008-9198-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Historical account; diabetes mellitus; body mass; Lung; ovarian carcinoma; tumors; physical activity; aggressive behavior; prostate cancer; Metabolism; Cancer DO - http://dx.doi.org/10.1007/s10552-008-9198-6 ER - TY - JOUR T1 - Cerebral sparganosis: a diagnostic challenge AN - 20656410; 9387451 AB - Cerebral sparganosis is a rare cestode larval parasitic infestation of the nervous system. We report a 28-year-old female from South India with a temporo-occipital mass lesion, which mimicked a tuberculoma on imaging. She received antituberculous therapy for 7 months. Surgical excision of the mass revealed a parasitic abscess containing larval form of Sparganum mansoni. Cerebral sparganosis can closely mimic tuberculoma or neoplastic lesions. Hence, in areas endemic for tuberculosis, such as India, it is appropriate to suggest that histological diagnosis be sought in tuberculoma mimicking lesions, especially when the lesion is not responding to treatment. JF - British Journal of Neurosurgery AU - Rengarajan, S AU - Nanjegowda, N AU - Bhat, D AU - Mahadevan, A AU - Sampath, S AU - Krishna, S AD - Departments of Neurosurgery & Neuropathology, National Institute of Mental Health and NeuroSciences, Bangalore, India Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 784 EP - 786 PB - Taylor & Francis Ltd., 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 22 IS - 6 SN - 0268-8697, 0268-8697 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Mimicry KW - Nervous system KW - Infestation KW - Mycobacterium KW - Tuberculosis KW - Abscesses KW - Neurosurgery KW - Cestoda KW - Tuberculoma KW - J 02490:Miscellaneous KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20656410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+Consumer+Research+%281986-1998%29&rft.atitle=The+Nature+and+Methodological+Implications+of+the+Cognitive+Representation+of+Products&rft.au=Johnson%2C+Michael+D%3BFornell%2C+Claes&rft.aulast=Johnson&rft.aufirst=Michael&rft.date=1987-09-01&rft.volume=14&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consumer+Research+%281986-1998%29&rft.issn=00935301&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mimicry; Infestation; Nervous system; Tuberculosis; Abscesses; Neurosurgery; Tuberculoma; Mycobacterium; Cestoda DO - http://dx.doi.org/10.1080/02688690802088073 ER - TY - JOUR T1 - Prenatal and perinatal risk factors for neuroblastoma AN - 20629417; 9355985 AB - Neuroblastoma is a rare embryonal tumor of childhood for which risk factors are not well known. Using a nested case-control design, we investigated prenatal, perinatal and neonatal risk factors in detail by linking 245 pediatric neuroblastoma cases identified in the Swedish Cancer Register diagnosed in the year 1973-1995 with the Swedish Medical Birth Register. Five living controls per case were randomly selected from the birth registry, matched by gender and age. Increased risks were associated with maternal anemia during pregnancy (odds ratio (OR) = 2.95, 95% confidence interval (CI): 1.53, 5.69), neonatal respiratory distress (OR = 3.61, 95% CI: 1.41, 9.24) and low (below or equal to 7) 1-min Apgar score (OR = 2.23, 95% CI: 1.41, 3.52). Increased risks were limited to cases diagnosed before 1 year of age. Markers of prenatal, perinatal and neonatal distress may be associated with neuroblastoma in infancy, but not with diagnoses at 1 year or above. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Bluhm, Elizabeth AU - McNeil, Dawn Elizabeth AU - Cnattingius, Sven AU - Gridley, Gloria AU - El Ghormli, Laure AU - Fraumeni Jr, Joseph F AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, elizabeth.c.bluhm@medstar.net Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2885 EP - 2890 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 12 SN - 0020-7136, 0020-7136 KW - CSA Neurosciences Abstracts; Risk Abstracts KW - Age KW - anemia KW - Pediatrics KW - Anemia KW - tumors KW - Tumors KW - Children KW - Neuroblastoma KW - Cancer KW - Pregnancy KW - prenatal experience KW - Risk factors KW - Gender KW - Neonates KW - N3 11003:Developmental neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20629417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Prenatal+and+perinatal+risk+factors+for+neuroblastoma&rft.au=Bluhm%2C+Elizabeth%3BMcNeil%2C+Dawn+Elizabeth%3BCnattingius%2C+Sven%3BGridley%2C+Gloria%3BEl+Ghormli%2C+Laure%3BFraumeni+Jr%2C+Joseph+F&rft.aulast=Bluhm&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=123&rft.issue=12&rft.spage=2885&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23847 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Pediatrics; Risk factors; Anemia; Tumors; Neonates; Children; Cancer; Neuroblastoma; Pregnancy; prenatal experience; anemia; Gender; tumors DO - http://dx.doi.org/10.1002/ijc.23847 ER - TY - JOUR T1 - Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent AN - 20626473; 9355957 AB - A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the leader peptide at the N-terminus. These results were fully confirmed by the molecular mass of rMnSOD as evaluated by ES/MS analysis (26662.7 Da) and the nucleotide sequence of the MnSOD cDNA. The role of the leader peptide in rMnSOD was investigated using a fluorescent and/or 68Gallium-labelled synthetic peptide. The labelled peptide permeated MCF-7 cells and uptake could be inhibited in the presence of an excess of oestrogen. In vivo it was taken up by the tumour, suggesting that the molecule can be used for both therapy and diagnosis. The in vitro and in vivo pharmacology tests confirmed that rMnSOD is only oncotoxic for tumour cells expressing oestrogen receptors. Pharmacokinetic studies in animals performed with 125I- and 131I-labelled proteins confirmed that, when administered systemically, rMnSOD selectively reached the tumour, where its presence was unambiguously demonstrated by scintigraphic and PET scans. PCR analysis revealed that Bax gene expression was increased and the Bcl2 gene was down regulated in MCF7 cells treated with rMnSOD, which suggests that the protein induces a pro-apoptotic mechanism. JF - International Journal of Cancer AU - Mancini, Aldo AU - Borrelli, Antonella AU - Schiattarella, Antonella AU - Aloj, Luigi AU - Aurilio, Michela AU - Morelli, Franco AU - Pica, Alessandra AU - Occhiello, Antonella AU - Lorizio, Roberto AU - Mancini, Roberto AU - Sica, Alessandro AU - Mazzarella, Lelio AU - Sica, Filomena AU - Grieco, Paolo AU - Novellino, Ettore AU - Pagnozzi, Daniela AU - Pucci, Piero AU - Rommelaere, Jean AD - Department of Molecular Biology and Biotherapy, National Cancer Institute G. Pascale Naples, Naples, Italy, aldo_mancini@tiscali.it Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2684 EP - 2695 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 11 SN - 0020-7136, 0020-7136 KW - Biotechnology and Bioengineering Abstracts KW - synthetic peptides KW - Pharmacology KW - Nucleotide sequence KW - Antitumor agents KW - Protein sorting signals KW - Pharmacokinetics KW - N-Terminus KW - Liposarcoma KW - Superoxide dismutase KW - Bax protein KW - Polymerase chain reaction KW - Estrogen receptors KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20626473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Biophysical+and+biochemical+characterization+of+a+liposarcoma-derived+recombinant+MnSOD+protein+acting+as+an+anticancer+agent&rft.au=Mancini%2C+Aldo%3BBorrelli%2C+Antonella%3BSchiattarella%2C+Antonella%3BAloj%2C+Luigi%3BAurilio%2C+Michela%3BMorelli%2C+Franco%3BPica%2C+Alessandra%3BOcchiello%2C+Antonella%3BLorizio%2C+Roberto%3BMancini%2C+Roberto%3BSica%2C+Alessandro%3BMazzarella%2C+Lelio%3BSica%2C+Filomena%3BGrieco%2C+Paolo%3BNovellino%2C+Ettore%3BPagnozzi%2C+Daniela%3BPucci%2C+Piero%3BRommelaere%2C+Jean&rft.aulast=Mancini&rft.aufirst=Aldo&rft.date=2008-12-01&rft.volume=123&rft.issue=11&rft.spage=2684&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23791 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Liposarcoma; synthetic peptides; Pharmacology; Superoxide dismutase; Nucleotide sequence; Bax protein; Polymerase chain reaction; Antitumor agents; Estrogen receptors; Pharmacokinetics; Protein sorting signals; N-Terminus DO - http://dx.doi.org/10.1002/ijc.23791 ER - TY - JOUR T1 - New complexities in helper T cell fate determination and the implications for autoimmune diseases AN - 20522840; 9198244 AB - Recently, new complexities in cell fate decision for helper T cells have emerged. One new lineage, which has come to be called Th17 cells, selectively produces proinflammatory cytokines including interleukin-17 (IL-17, A and F), IL-21, and IL-22. In conjunction with transforming growth factor beta -1 (TGF beta -1), IL-6, IL-21, and IL-23, which activate the transcription factor, signal transducer, and activator of transcription 3 (Stat3), the expression of another transcription factor, retinoic acid-related orphan receptor- Gamma t (ROR Gamma t) leads to the differentiation of Th17 cells in mice. Other cytokines including IL-2, IL-4, interferon- Gamma (IFN- Gamma ), and IL-27 inhibit Th17 differentiation. However, IL-2 acting with TGF beta -1 induces differentiation of naive CD4+ T cells to become regulatory T cells (Tregs). Th17 cells are now known to play an important role not only in the pathogenesis of inflammation and autoimmune diseases, but also host defense against extracellular bacteria. Conversely, extensive data substantiate the role of Tregs as essential in maintenance of peripheral tolerance. Selectively targeting Tregs and Th17 cells are likely to be important strategies in the treatment of inflammatory and autoimmune diseases in humans. JF - Modern Rheumatology AU - Takatori, Hiroaki AU - Kanno, Yuka AU - Chen, Zhi AU - O'Shea, John J AD - Lymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 10, Room 13C120, 10 Center Drive, MSC-1930, Bethesda, MD, 20892, USA, takatorih@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 533 EP - 541 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 VL - 18 IS - 6 SN - 1439-7595, 1439-7595 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Immunoregulation KW - Interleukin 4 KW - Data processing KW - Interleukin 2 KW - Stat3 protein KW - Helper cells KW - Autoimmune diseases KW - Interleukin 21 KW - Immunological tolerance KW - Inflammation KW - Differentiation KW - CD4 antigen KW - Interleukin 22 KW - Interleukin 23 KW - Inflammatory diseases KW - Interleukin 17 KW - Transcription factors KW - Interleukin 27 KW - Lymphocytes T KW - Cell fate KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Modern+Rheumatology&rft.atitle=New+complexities+in+helper+T+cell+fate+determination+and+the+implications+for+autoimmune+diseases&rft.au=Takatori%2C+Hiroaki%3BKanno%2C+Yuka%3BChen%2C+Zhi%3BO%27Shea%2C+John+J&rft.aulast=Takatori&rft.aufirst=Hiroaki&rft.date=2008-12-01&rft.volume=18&rft.issue=6&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Modern+Rheumatology&rft.issn=14397595&rft_id=info:doi/10.1007%2Fs10165-008-0099-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Immunoregulation; Interleukin 4; Data processing; Interleukin 2; Stat3 protein; Helper cells; Autoimmune diseases; Interleukin 21; Immunological tolerance; Inflammation; Differentiation; Interleukin 22; CD4 antigen; Interleukin 23; Inflammatory diseases; Transcription factors; Interleukin 17; Interleukin 27; Lymphocytes T; Cell fate DO - http://dx.doi.org/10.1007/s10165-008-0099-z ER - TY - JOUR T1 - Modeling weight-loss maintenance to help prevent body weight regain AN - 20390575; 9070164 AB - Background: Lifestyle intervention can successfully induce weight loss in obese persons, at least temporarily. However, there currently is no way to quantitatively estimate the changes of diet or physical activity required to prevent weight regain. Such a tool would be helpful for goal-setting, because obese patients and their physicians could assess at the outset of an intervention whether long-term adherence to the calculated lifestyle change is realistic. Objective: We aimed to calculate the expected change of steady-state body weight arising from a given change in dietary energy intake and, conversely, to calculate the modification of energy intake required to maintain a particular body-weight change. Design: We developed a mathematical model using data from 8 longitudinal weight-loss studies representing 157 subjects with initial body weights ranging from 68 to 160 kg and stable weight losses between 7 and 54 kg. Results: Model calculations closely matched the change data (R super(2) = 0.83, X super(2) = 2.1, P < 0.01 for weight changes; R super(2) = 0.91, X super(2) = 0.87, P < 0.0004 for energy intake changes). Our model performed significantly better than the previous models for which X super(2) values were 10-fold those of our model. The model also accurately predicted the proportion of weight change resulting from the loss of body fat (R super(2) = 0.90). Conclusions: Our model provides realistic calculations of body-weight change and of the dietary modifications required for weight-loss maintenance. Because the model was implemented by using standard spreadsheet software, it can be widely used by physicians and weight-management professionals. JF - American Journal of Clinical Nutrition AU - Hall, K D AU - Jordan, P N AD - NIDDK/NIH, 12A South Drive, Room 4007, Bethesda, MD 20892-5621, USA, kevinh@niddk.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 VL - 88 IS - 6 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Obesity KW - Weight control KW - Diet (weight control) KW - Physicians KW - Standards KW - Exercise KW - Modeling KW - Maintenance KW - Lifestyle KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20390575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Modeling+weight-loss+maintenance+to+help+prevent+body+weight+regain&rft.au=Hall%2C+K+D%3BJordan%2C+P+N&rft.aulast=Hall&rft.aufirst=K&rft.date=2008-12-01&rft.volume=88&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Weight control; Diet (weight control); Standards; Physicians; Exercise; Maintenance; Modeling; Lifestyle ER - TY - JOUR T1 - Elevated Levels of Alanine Aminotransferase and Hepatitis A in the Context of a Pediatric Malaria Vaccine Trial in a Village in Mali AN - 20388948; 9069799 AB - A Phase 1 study of the apical membrane antigen malaria vaccine AMA1-C1/Alhydrogel was conducted in 2-3-year-old children in a village in Mali. A high frequency of elevated levels of alanine aminotransferase (ALT) caused by hepatitis A was seen, with 8 of 36 children diagnosed by specific IgM antibody over the course of the study. Hepatitis A is a common cause of asymptomatic elevations of ALT levels in children, particularly in less-developed settings. Investigators should be aware of the frequency of hepatitis A in this age group to guard against inadvertently facilitating transmission at study facilities and to properly evaluate symptomatic or asymptomatic elevations of ALT levels. JF - American Journal of Tropical Medicine and Hygiene AU - Ellis, R D AU - Dicko, A AU - Sagara, I AU - Kamate, B AU - Guindo, O AU - Niambele, M B AU - Sogoba, M AU - Doumbo, O AD - 5640 Fishers Lane, TB1, Room 1119, Rockville, MD 20852, USA, ellisru@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 VL - 79 IS - 6 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; ASFA Aquaculture Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Age KW - Human diseases KW - Mali KW - Alanine KW - Pediatrics KW - Disease control KW - Malaria KW - Children KW - Alanine transaminase KW - Antibodies KW - Antigens KW - Hepatitis A KW - Age groups KW - Vaccines KW - Hygiene KW - Immunoglobulin M KW - K 03400:Human Diseases KW - Q1 08587:Diseases of Cultured Organisms KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22400:Human Diseases KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20388948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Elevated+Levels+of+Alanine+Aminotransferase+and+Hepatitis+A+in+the+Context+of+a+Pediatric+Malaria+Vaccine+Trial+in+a+Village+in+Mali&rft.au=Ellis%2C+R+D%3BDicko%2C+A%3BSagara%2C+I%3BKamate%2C+B%3BGuindo%2C+O%3BNiambele%2C+M+B%3BSogoba%2C+M%3BDoumbo%2C+O&rft.aulast=Ellis&rft.aufirst=R&rft.date=2008-12-01&rft.volume=79&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Antibodies; Human diseases; Antigens; Alanine; Disease control; Age groups; Malaria; Vaccines; Hygiene; Age; Pediatrics; Hepatitis A; Alanine transaminase; Children; Immunoglobulin M; Mali ER - TY - JOUR T1 - Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension AN - 20387068; 9070188 AB - Background: Essential hypertension is characterized by reciprocal relations between endothelial dysfunction and insulin resistance. Cocoa flavanols stimulate production of the vasodilator nitric oxide from vascular endothelium. Objective: The objective was to test the hypothesis that consumption of cocoa may simultaneously lower blood pressure, improve endothelial dysfunction, and ameliorate insulin resistance in subjects with essential hypertension. Design: We conducted a randomized, placebo-controlled, double-blind, crossover trial of a flavanol-rich cocoa drink (150 mL twice a day, approximately 900 mg flavanols/d) in individuals with essential hypertension (n = 20). Antihypertensive medications were discontinued before study enrollment. After a 7-d cocoa-free run-in period, cocoa or flavanol-poor placebo ( approximately 28 mg flavanols/d) treatment for 2 wk was followed by a 1-wk washout and then crossover to the other treatment arm. Blood pressure was measured thrice weekly. At baseline and after each treatment period, we assessed insulin sensitivity (hyperinsulinemic-isoglycemic glucose clamp) and insulin-stimulated changes in brachial artery diameter and forearm skeletal muscle capillary recruitment (Doppler ultrasound with or without microbubble contrast). Results: Cocoa treatment for 2 wk increased insulin-stimulated changes in brachial artery diameter when compared with placebo [median percentage increase from baseline (25th-75th percentile): 8.3 (4.2-11.3) compared with 5.9 (-0.3 to 9.6); P < 0.04]. Nevertheless, cocoa treatment did not significantly reduce blood pressure or improve insulin resistance and had no significant effects on skeletal muscle capillary recruitment, circulating plasma concentrations of adipocytokines, or endothelial adhesion molecules. Conclusions: Daily consumption of flavanol-rich cocoa for 2 wk is not sufficient to reduce blood pressure or improve insulin resistance in human subjects with essential hypertension. This trial was registered at chnicaltrials.gov as NCT00099476. JF - American Journal of Clinical Nutrition AU - Muniyappa, R AU - Hall, G AU - Kolodziej, T L AU - Karne, R J AU - Crandon, S K AU - Quon, MJ AD - Diabetes Unit, NCCAM, NIH, 9 Memorial Drive, Building 9, Room 1N-105 MSC 0920, Bethesda, MD, USA, quonm@nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 VL - 88 IS - 6 SN - 0002-9165, 0002-9165 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cocoa KW - Beverages KW - Doppler effect KW - Arteries KW - Recruitment KW - Glucose KW - Clinical trials KW - Blood pressure KW - Insulin KW - Antihypertensives KW - Vasodilation KW - Endothelium KW - Skeletal muscle KW - Nitric oxide KW - Ultrasound KW - Forearm KW - Vasodilators KW - Hypertension KW - Vascular system KW - A 01360:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20387068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Cocoa+consumption+for+2+wk+enhances+insulin-mediated+vasodilatation+without+improving+blood+pressure+or+insulin+resistance+in+essential+hypertension&rft.au=Muniyappa%2C+R%3BHall%2C+G%3BKolodziej%2C+T+L%3BKarne%2C+R+J%3BCrandon%2C+S+K%3BQuon%2C+MJ&rft.aulast=Muniyappa&rft.aufirst=R&rft.date=2008-12-01&rft.volume=88&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cocoa; Beverages; Doppler effect; Arteries; Recruitment; Glucose; Clinical trials; Insulin; Blood pressure; Antihypertensives; Vasodilation; Endothelium; Nitric oxide; Skeletal muscle; Ultrasound; Forearm; Vascular system; Hypertension; Vasodilators ER - TY - JOUR T1 - Relapsing Fever Spirochetes Retain Infectivity After Prolonged in vitro Cultivation AN - 20364263; 9047646 AB - Borrelia hermsii and Borrelia burgdorferi, two closely related spirochetes, are the etiological agents of tick-borne relapsing fever and Lyme disease, respectively. Previous studies have shown the loss of infectivity of B. burgdorferi is associated with in vitro cultivation. This diminished infectivity of B. burgdorferi has occurred as early as three in vitro passages, and the loss of plasmids have been observed with these less virulent to noninfective cultures. The effects of long-term in vitro cultivation on B. hermsii have not been investigated. However, understanding the degree of genomic degradation during in vitro cultivation is important for investigating pathogenic mechanisms of spirochetes. In this study, we analyzed the effects of continuous in vitro cultivation on the genomic composition and infectivity of B. hermsii and B. turicatae. We report that all seven isolates of B. hermsii and the one isolate of B. turicatae examined retained infectivity in mice after 1 year of continuous in vitro cultivation. Furthermore, there were few apparent differences in the plasmid profiles after long-term cultivation. Two isolates of B. hermsii remained infective after high passage despite losing a portion of the 200-kb linear plasmid containing the fhbA gene encoding the factor H binding protein. Also, sequence analysis of multiple B. hermsii isolates demonstrated two types of fhbA with complete congruence with the two genomic groups of B. hermsii spirochetes. Therefore, these results suggest that relapsing fever spirochetes are genetically stable during in vitro cultivation, and the fhbA-containing segment of DNA that is lost during cultivation is not required for infection. JF - Vector Borne and Zoonotic Diseases AU - Lopez, JE AU - Schrumpf, ME AU - Raffel, S J AU - Policastro, P F AU - Porcella, S F AU - Schwan, T G AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 813 EP - 820 VL - 8 IS - 6 SN - 1530-3667, 1530-3667 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Borrelia hermsii KW - Borrelia burgdorferi KW - Relapsing fever KW - Vectors KW - Plasmids KW - Infection KW - Spirochetes KW - Infectivity KW - tick-borne diseases KW - DNA KW - genomics KW - Lyme disease KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20364263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vector+Borne+and+Zoonotic+Diseases&rft.atitle=Relapsing+Fever+Spirochetes+Retain+Infectivity+After+Prolonged+in+vitro+Cultivation&rft.au=Lopez%2C+JE%3BSchrumpf%2C+ME%3BRaffel%2C+S+J%3BPolicastro%2C+P+F%3BPorcella%2C+S+F%3BSchwan%2C+T+G&rft.aulast=Lopez&rft.aufirst=JE&rft.date=2008-12-01&rft.volume=8&rft.issue=6&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Vector+Borne+and+Zoonotic+Diseases&rft.issn=15303667&rft_id=info:doi/10.1089%2Fvbz.2008.0033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Spirochetes; Infectivity; Relapsing fever; DNA; tick-borne diseases; Vectors; genomics; Infection; Plasmids; Lyme disease; Borrelia hermsii; Borrelia burgdorferi DO - http://dx.doi.org/10.1089/vbz.2008.0033 ER - TY - JOUR T1 - Antimicrobial property of a herbal preparation containing Dalbergia sissoo and Datura stramonium with cow urine against pathogenic bacteria AN - 20349469; 9024645 AB - In this study, a herbal preparation containing Dalbergia sissoo and Datura stramoium with cow urine (DSDS), was evaluated for its antibacterial potential against pathogenic strains of gram-positive (Staphylococcus aureus and Streptococcus pneumoniae) and gram-negative (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) bacteria. Antibacterial activity was compared to standard antibiotic drugs i.e. Chloramphenicol (30 mcg), Ampicillin (10 mcg), Nalidixic acid (10 mcg) and Rifampicin (30 mcg). Cow urine extract was found to be most active against both gram-positive as well as gram-negative bacteria. Clinical isolate of S. aureus showed higher sensitivity towards cow urine extract of DSDS than standard strains, and inhibited growth on most regulatory levels such as inhibition of protein, DNA, RNA and peptidoglycan synthesis. The results of the present study shows that the cow urine extract of DSDS may be used as a potent antiseptic preparation for prevention and treatment of chronic bacterial infections. JF - International Journal of Immunopathology and Pharmacology AU - Yadav, H AU - Yadav, M AU - Jain, S AU - Bhardwaj, A AU - Singh, V AU - Parkash, O AU - Marotta, F AD - Clinical Research Centre, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, yadavhariom@gmail.com Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1013 EP - 1020 VL - 21 IS - 4 SN - 0394-6320, 0394-6320 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Antibacterial activity KW - Dalbergia sissoo KW - peptidoglycans KW - Antibiotics KW - Rifampin KW - Datura stramonium KW - Antiseptics KW - Gram-negative bacteria KW - Escherichia coli KW - Nalidixic acid KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - Drugs KW - Clinical isolates KW - Chloramphenicol KW - Datura KW - Transcription KW - Ampicillin KW - Antimicrobial agents KW - Streptococcus pneumoniae KW - RNA KW - Urine KW - Chronic infection KW - DNA KW - Klebsiella pneumoniae KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20349469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Immunopathology+and+Pharmacology&rft.atitle=Antimicrobial+property+of+a+herbal+preparation+containing+Dalbergia+sissoo+and+Datura+stramonium+with+cow+urine+against+pathogenic+bacteria&rft.au=Yadav%2C+H%3BYadav%2C+M%3BJain%2C+S%3BBhardwaj%2C+A%3BSingh%2C+V%3BParkash%2C+O%3BMarotta%2C+F&rft.aulast=Yadav&rft.aufirst=H&rft.date=2008-12-01&rft.volume=21&rft.issue=4&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Immunopathology+and+Pharmacology&rft.issn=03946320&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Chloramphenicol; Antibacterial activity; Ampicillin; peptidoglycans; Transcription; Antibiotics; Antimicrobial agents; Rifampin; RNA; Urine; Antiseptics; Gram-negative bacteria; Chronic infection; Nalidixic acid; DNA; Drugs; Streptococcus pneumoniae; Datura; Datura stramonium; Dalbergia sissoo; Escherichia coli; Staphylococcus aureus; Pseudomonas aeruginosa; Klebsiella pneumoniae ER - TY - JOUR T1 - Toll-like receptor 7 is not necessary for retroviral neuropathogenesis but does contribute to virus-induced neuroinflammation AN - 20298585; 8903211 AB - Toll-like receptor 7 (TLR7) recognizes guanidine-rich single-stranded (ss) viral RNA and is an important mediator of peripheral immune responses to several ssRNA viruses. However, the role that TLR7 plays in regulating the innate immune response to ssRNA virus infections in specific organs is not as clear. This is particularly true in the central nervous system (CNS) where microglia and astrocytes are often the first cells responding to virus infection instead of dendritic cells. In the current study, we examined the mechanism by which TLR7 contributes to ssRNA virus-induced neuroinflammation using a mouse model of polytropic retrovirus infection. The authors found that TLR7 was necessary for the early production of certain cytokines and chemokines, including CCL2 and tumor necrosis factor (TNF) and was also involved in the early activation of astrocytes. However, TLR7 was not necessary for cytokine production and astrocyte activation at later stages of infection and did not alter viral pathogenesis or viral replication in the brain. This suggests that other pathogen recognition receptors may be able to compensate for the lack of TLR7 during retrovirus infection in the CNS. JF - Journal of Neurovirology AU - Lewis, S D AU - Butchi, N B AU - Khaleduzzaman, M AU - Morgan, T W AU - Du, M AU - Pourciau, S AU - Baker, D G AU - Akira, S AU - Peterson, KE AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, 903 S. 4th St., Hamilton, MT 59840, USA, petersonka@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 492 EP - 502 VL - 14 IS - 6 SN - 1355-0284, 1355-0284 KW - Virology & AIDS Abstracts; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Central nervous system KW - Chemokines KW - Monocyte chemoattractant protein 1 KW - Astrocytes KW - Replication KW - Tumor necrosis factor KW - Animal models KW - Brain KW - Neuropathogenesis KW - Pathogens KW - Infection KW - Microglia KW - Inflammation KW - Dendritic cells KW - Retrovirus KW - RNA KW - Cytokines KW - TLR7 protein KW - Toll-like receptors KW - V 22350:Immunology KW - W 30940:Products KW - N 14830:RNA KW - F 06910:Microorganisms & Parasites KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20298585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurovirology&rft.atitle=Toll-like+receptor+7+is+not+necessary+for+retroviral+neuropathogenesis+but+does+contribute+to+virus-induced+neuroinflammation&rft.au=Lewis%2C+S+D%3BButchi%2C+N+B%3BKhaleduzzaman%2C+M%3BMorgan%2C+T+W%3BDu%2C+M%3BPourciau%2C+S%3BBaker%2C+D+G%3BAkira%2C+S%3BPeterson%2C+KE&rft.aulast=Lewis&rft.aufirst=S&rft.date=2008-12-01&rft.volume=14&rft.issue=6&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurovirology&rft.issn=13550284&rft_id=info:doi/10.1080%2F13550280802345723 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Central nervous system; Chemokines; Monocyte chemoattractant protein 1; Astrocytes; Replication; Tumor necrosis factor; Neuropathogenesis; Brain; Animal models; Pathogens; Microglia; Infection; Inflammation; Dendritic cells; Retrovirus; RNA; Cytokines; TLR7 protein; Toll-like receptors DO - http://dx.doi.org/10.1080/13550280802345723 ER - TY - JOUR T1 - The 5' end of two redundant sRNAs is involved in the regulation of multiple targets, including their own regulator AN - 20274190; 8921080 AB - Small RNAs are widespread regulators of gene expression in numerous organisms. This study describes the mode of action of two redundant Escherichia coli sRNAs, OmrA and OmrB, that downregulate the expression of multiple targets, most of which encode outer membrane proteins. Our results show that both sRNAs directly interact with at least two of these target mRNAs, ompT and cirA, in the vicinity of the translation initiation region, consistent with control of these targets being dependent on both Hfq and RNase E. Interestingly, these interactions depend on short stretches of complementarity and involve the conserved 5' end of OmrA/B. A mutation in this region abolishes control of all OmrA/B targets tested thus far, thereby highlighting the crucial role of the OmrA/B 5' end. This allowed us, by looking for mRNA sequences complementary to the OmrA/B 5' end, to identify ompR as an additional direct target of these two sRNAs. Since the OmpR transcriptional regulator activates expression of both omrA and omrB genes, this newly identified control should result in an autoregulatory loop limiting the amount of OmrA/B sRNAs. JF - Nucleic Acids Research AU - Guillier, Maude AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, susang@helix.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 6781 EP - 6794 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - 21 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Gene expression KW - outer membrane proteins KW - ribonuclease E KW - Translation initiation KW - Escherichia coli KW - Transcription KW - Mutation KW - Complementarity KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20274190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+5%27+end+of+two+redundant+sRNAs+is+involved+in+the+regulation+of+multiple+targets%2C+including+their+own+regulator&rft.au=Guillier%2C+Maude%3BGottesman%2C+Susan&rft.aulast=Guillier&rft.aufirst=Maude&rft.date=2008-12-01&rft.volume=36&rft.issue=21&rft.spage=6781&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn742 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; outer membrane proteins; Translation initiation; ribonuclease E; Transcription; Mutation; Complementarity; Escherichia coli DO - http://dx.doi.org/10.1093/nar/gkn742 ER - TY - JOUR T1 - Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world AN - 20273167; 8921090 AB - The first bacterial genome was sequenced in 1995, and the first archaeal genome in 1996. Soon after these breakthroughs, an exponential rate of genome sequencing was established, with a doubling time of approximately 20 months for bacteria and approximately 34 months for archaea. Comparative analysis of the hundreds of sequenced bacterial and dozens of archaeal genomes leads to several generalizations on the principles of genome organization and evolution. A crucial finding that enables functional characterization of the sequenced genomes and evolutionary reconstruction is that the majority of archaeal and bacterial genes have conserved orthologs in other, often, distant organisms. However, comparative genomics also shows that horizontal gene transfer (HGT) is a dominant force of prokaryotic evolution, along with the loss of genetic material resulting in genome contraction. A crucial component of the prokaryotic world is the mobilome, the enormous collection of viruses, plasmids and other selfish elements, which are in constant exchange with more stable chromosomes and serve as HGT vehicles. Thus, the prokaryotic genome space is a tightly connected, although compartmentalized, network, a novel notion that undermines the 'Tree of Life' model of evolution and requires a new conceptual framework and tools for the study of prokaryotic evolution. JF - Nucleic Acids Research AU - Koonin, Eugene V AU - Wolf, Yuri I AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA, koonin@ncbi.nlm.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 6688 EP - 6719 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - 21 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Chromosomes KW - Archaea KW - genomics KW - Evolutionary genetics KW - Plasmids KW - Evolution KW - Models KW - J 02310:Genetics & Taxonomy KW - A 01390:Forestry KW - N 14810:Methods KW - G 07770:Bacteria KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20273167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Genomics+of+bacteria+and+archaea%3A+the+emerging+dynamic+view+of+the+prokaryotic+world&rft.au=Koonin%2C+Eugene+V%3BWolf%2C+Yuri+I&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2008-12-01&rft.volume=36&rft.issue=21&rft.spage=6688&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn668 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Chromosomes; Evolutionary genetics; genomics; Plasmids; Evolution; Models; Archaea DO - http://dx.doi.org/10.1093/nar/gkn668 ER - TY - JOUR T1 - Respiratory Cancer and Inhaled Inorganic Arsenic in Copper Smelters Workers: A Linear Relationship with Cumulative Exposure that Increases with Concentration AN - 20244702; 8859425 AB - Background: Inhalation of high levels of airborne inorganic arsenic is a recognized cause of respiratory cancer. Although multiple epidemiologic studies have demonstrated this association, there have been few analyses of the mathematical relationship between cumulative arsenic exposure and risk of respiratory cancer, and no assessment as to whether and how arsenic concentration may modify this association. Objectives: The objective is an evaluation of the shape of the relationship between respiratory cancer mortality and cumulative inhaled arsenic exposure among copper smelter workers, and the modification of that relationship by arsenic concentration. Methods: We used Poisson regression methods to analyze data from a cohort of arsenic-exposed copper smelter workers under a linear-exponential model for the excess relative risk. Results: Within categories of arsenic concentration, the association between respiratory cancer and cumulative arsenic exposure was consistent with linearity. The slope of the linear relationship with cumulative exposure increased with increasing arsenic concentration category. Conclusions: Our results suggested a direct concentration effect from inhaled inorganic arsenic, whereby the excess relative risk for a fixed cumulative exposure was greater when delivered at a higher concentration and shorter duration than when delivered at a lower concentration and longer duration. JF - Environmental Health Perspectives AU - Lubin, J H AU - Moore, LE AU - Fraumeni, JF Jr AU - Cantor, K P AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 8042, Rockville, MD 20852 USA, lubinj@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1661 EP - 1665 VL - 116 IS - 12 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts; Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Risk assessment KW - Inhalation KW - Mortality KW - Arsenic KW - Data processing KW - Copper KW - Smelters KW - Cancer KW - Models KW - Workers KW - Regression analysis KW - Occupational exposure KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20244702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Respiratory+Cancer+and+Inhaled+Inorganic+Arsenic+in+Copper+Smelters+Workers%3A+A+Linear+Relationship+with+Cumulative+Exposure+that+Increases+with+Concentration&rft.au=Lubin%2C+J+H%3BMoore%2C+LE%3BFraumeni%2C+JF+Jr%3BCantor%2C+K+P&rft.aulast=Lubin&rft.aufirst=J&rft.date=2008-12-01&rft.volume=116&rft.issue=12&rft.spage=1661&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.11515 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inhalation; Risk assessment; Workers; Mortality; Arsenic; Data processing; Regression analysis; Copper; Smelters; Occupational exposure; Cancer; Models DO - http://dx.doi.org/10.1289/ehp.11515 ER - TY - JOUR T1 - Of Microbes and Membranes: Pathogenic Subversion of Host Cell Processes AN - 20240864; 8853172 AB - A recent gathering of researchers at the EMBO conference "At the joint edge of Cellular Microbiology and Cell Biology" was aimed at melding ideas from both scientific fields to advance our understanding of infectious diseases at the cellular level. Work presented at this meeting highlighted how pathogens exploit host cell membrane processes to their advantage and also revealed fundamental signaling and trafficking mechanisms of eukaryotic cells. JF - Cell Host & Microbe AU - Celli, Jean AU - Knodler, Leigh A AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA, jcelli@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 514 EP - 518 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 4 IS - 6 SN - 1931-3128, 1931-3128 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cell membranes KW - Infectious diseases KW - Conferences KW - Pathogens KW - Signal transduction KW - Joints KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20240864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Host+%26+Microbe&rft.atitle=Of+Microbes+and+Membranes%3A+Pathogenic+Subversion+of+Host+Cell+Processes&rft.au=Celli%2C+Jean%3BKnodler%2C+Leigh+A&rft.aulast=Celli&rft.aufirst=Jean&rft.date=2008-12-01&rft.volume=4&rft.issue=6&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Cell+Host+%26+Microbe&rft.issn=19313128&rft_id=info:doi/10.1016%2Fj.chom.2008.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell membranes; Conferences; Infectious diseases; Pathogens; Joints; Signal transduction DO - http://dx.doi.org/10.1016/j.chom.2008.11.007 ER - TY - JOUR T1 - Sorting of Transgenic Secretory Proteins in Rhesus Macaque Parotid Glands After Adenovirus-Mediated Gene Transfer AN - 20148065; 8876185 AB - We have previously used viral vectors encoding either human growth hormone (hGH) or erythropoietin (hEPO) to study the sorting of transgenic proteins in mouse and minipig salivary glands. Whereas hGH (a regulated secretory pathway [RSP] protein) is secreted predominantly into saliva in both species, hEPO (a constitutive secretory pathway [CSP] protein) is found primarily in the bloodstream with mice, but overwhelmingly in saliva with minipigs. In view of the hEPO sorting difference, we have conducted a similar study in nonhuman primates. Specifically, we examined hGH and hEPO sorting after adenoviral (Ad) vector-mediated gene transfer to parotid glands of rhesus macaques, another large and important animal model. Two groups (n = 2 per dose group; total n = 8) of male macaques received either 10 super(10) particles per gland (low-dose group) or 10 super(11) particles per gland (high-dose group) of adenoviral (Ad) vectors encoding either hGH (AdhGH) or hEPO (Ad-hEPO) via intraoral cannulation of both parotid glands. All macaques tolerated administration of Ad vectors well, with no clinically significant changes observed in any hematological and serum chemistry parameters. In AdhGH-rreated animals, hGH was secreted exclusively into saliva. In contrast, after AdhEPO delivery, hEPO was secreted both in serum and saliva, at levels intermediate between mice and minipigs. We conclude that RSP proteins are faithfully secreted into saliva in all model species tested, whereas patterns of CSP protein secretion are variable. JF - Human Gene Therapy AU - Voutetakis, A AU - Zheng, C AU - Metzger, M AU - Cotrim, A P AU - Donahue, R E AU - Dunbar, CE AU - Baum, B J AD - Molecular Physiology and Therapeutics Branch, Building 10, Room 1N113, MSC-1190, 9000 Rockville Pike, Bethesda, MD 20892, USA, bbaum@dir.nidcr.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1401 EP - 1405 VL - 19 IS - 12 SN - 1043-0342, 1043-0342 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Growth hormone KW - Gene therapy KW - Secretion KW - Parotid gland KW - CSP protein KW - Animal models KW - Salivary gland KW - Primates KW - Expression vectors KW - Erythropoietin KW - Macaca mulatta KW - Saliva KW - Cannulation KW - W 30905:Medical Applications KW - V 22410:Animal Diseases KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20148065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Sorting+of+Transgenic+Secretory+Proteins+in+Rhesus+Macaque+Parotid+Glands+After+Adenovirus-Mediated+Gene+Transfer&rft.au=Voutetakis%2C+A%3BZheng%2C+C%3BMetzger%2C+M%3BCotrim%2C+A+P%3BDonahue%2C+R+E%3BDunbar%2C+CE%3BBaum%2C+B+J&rft.aulast=Voutetakis&rft.aufirst=A&rft.date=2008-12-01&rft.volume=19&rft.issue=12&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Expression vectors; Growth hormone; Gene therapy; Erythropoietin; Secretion; Parotid gland; Animal models; CSP protein; Saliva; Salivary gland; Cannulation; Macaca mulatta; Primates DO - http://dx.doi.org/10.1089/hum.2008.034 ER - TY - JOUR T1 - Potency and Fate Specification in CNS Stem Cell Populations In Vitro AN - 20102264; 8769926 AB - To realize the promise of stem cell biology, it is important to identify the precise time in the history of the cell when developmental potential is restricted. To achieve this goal, we developed a real-time imaging system that captures the transitions in fate, generating neurons, astrocytes, and oligodendrocytes from single CNS stem cells in vitro. In the presence of bFGF, tripotent cells normally produce specified progenitors through a bipotent intermediate cell type. Surprisingly, the tripotent state is reset at each passage. The cytokine CNTF is thought to instruct multipotent cells to an astrocytic fate. We demonstrate that CNTF both directs astrogliogenesis from tripotent cells, bypassing two of the three normal bipotent intermediates, and later promotes the expansion of specified astrocytic progenitors. These results show how discrete cell types emerge from a multipotent cell and provide a strong basis for future studies to determine the molecular basis of fate specification. JF - Cell Stem Cell AU - Ravin, Rea AU - Hoeppner, Daniel J AU - Munno, David M AU - Carmel, Liran AU - Sullivan, Jim AU - Levitt, David L AU - Miller, Jennifer L AU - Athaide, Christopher AU - Panchision, David M AU - McKay, Ronald DG AD - Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, mckay@codon.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 670 EP - 680 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 3 IS - 6 SN - 1934-5909, 1934-5909 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - STEMCELL KW - Central nervous system KW - Stem cells KW - Neurogenesis KW - Oligodendrocytes KW - Astrocytes KW - Cytokines KW - Fibroblast growth factor 2 KW - Gliogenesis KW - W 30910:Imaging KW - N3 11007:Neurobiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20102264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=Potency+and+Fate+Specification+in+CNS+Stem+Cell+Populations+In+Vitro&rft.au=Ravin%2C+Rea%3BHoeppner%2C+Daniel+J%3BMunno%2C+David+M%3BCarmel%2C+Liran%3BSullivan%2C+Jim%3BLevitt%2C+David+L%3BMiller%2C+Jennifer+L%3BAthaide%2C+Christopher%3BPanchision%2C+David+M%3BMcKay%2C+Ronald+DG&rft.aulast=Ravin&rft.aufirst=Rea&rft.date=2008-12-01&rft.volume=3&rft.issue=6&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=Cell+Stem+Cell&rft.issn=19345909&rft_id=info:doi/10.1016%2Fj.stem.2008.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Central nervous system; Neurogenesis; Stem cells; Astrocytes; Oligodendrocytes; Cytokines; Fibroblast growth factor 2; Gliogenesis DO - http://dx.doi.org/10.1016/j.stem.2008.09.012 ER - TY - JOUR T1 - HER2-Specific Affibody-Conjugated Thermosensitive Liposomes (Affisomes) for Improved Delivery of Anticancer Agents AN - 20066382; 10061161 AB - Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (ZHER2:342-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characteristics and stability of the resulting nanoparticles denoted as 'Affisomes' were investigated. Thermosensitive small unilamellar vesicle (SUV) liposomes of (80-100 nm) a diameter consisting of dipalmitoyl phosphatidylcholine (DPPC, Tm 41°C) as the matrix lipid and a maleimide-conjugated pegylated phospholipid (DSPE-MaL-PEG2000) were prepared by probe sonication. Fluorescent probes were incorporated into liposomes for biophysical and/or biochemical analysis and/or triggered-release assays. Affibody was conjugated to these liposomes via its C-terminal cysteine by incubation in the presence of a reducing agent (e.g., tributylphosphine) for 16-20 hours under an argon atmosphere. Lipid-conjugated affibody molecule was visible as an 11.3-kDa band on a 4-12% Bis/Tris gel under reducing conditions. Affibody conjugation yields were ~70% at a protein-lipid ratio of 20 is a subset of g/mg, with an average number of 200 affibody molecules per Affisome. Affibody conjugation to thermosensitive liposomes did not have any significant effect on the hydrodynamic size distribution of the liposomes. Thermosensitivity of Affisomes was determined by monitoring the release of entrapped calcein (a water-soluble fluorescent probe, lambda ex/em 490/515 nm) as a function of temperature. Calcein was released from Affisomes (thermosensitive liposomes with affibody-Targeted SUV) as well as nontargeted SUV (thermosensitive liposomes without affibody) in a temperature-dependent manner, with optimal leakage (90-100%) at 41°C. In contrast, liposomes prepared from Egg phosphatidyl choline (Egg PC, Tm ~0°C) under similar conditions released only 5-10% calcein at 41°C. Affisomes, when stored at room temperature, retained > 90% entrapped calcein up to 7 days. Moreover, incubation of liposomes in phosphate-buffered saline, supplemented with 10% heat-inactivated serum (fetal bovine serum) did not result in a destabilization of liposomes. Therefore, Affisomes present promising, novel drug-delivery candidates for breast cancer targeting. JF - Journal of Liposome Research AU - Puri, Anu AU - Kramer-Marek, Gabriela AU - Campbell-Massa, Ryan AU - Yavlovich, Amichai AU - Tele, Shrikant C AU - Lee, Sang-Bong AU - Clogston, Jeffrey D AU - Patri, Anil K AU - Blumenthal, Robert AU - Capala, Jacek AD - CCR Nanobiology Program, NCI-Frederick, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 293 EP - 307 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 18 IS - 4 SN - 0898-2104, 0898-2104 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Choline KW - Hydrodynamics KW - Calcein KW - Lipids KW - Probes KW - Lecithin KW - Biochemical analysis KW - Atmosphere KW - Argon KW - Reducing agents KW - Fluorescent indicators KW - Vesicles KW - Phospholipids KW - Temperature effects KW - Physical characteristics KW - Leakage KW - Tumors KW - Antitumor agents KW - Liposomes KW - Sonication KW - Cysteine KW - Breast cancer KW - nanoparticles KW - Size distribution KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20066382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Liposome+Research&rft.atitle=HER2-Specific+Affibody-Conjugated+Thermosensitive+Liposomes+%28Affisomes%29+for+Improved+Delivery+of+Anticancer+Agents&rft.au=Puri%2C+Anu%3BKramer-Marek%2C+Gabriela%3BCampbell-Massa%2C+Ryan%3BYavlovich%2C+Amichai%3BTele%2C+Shrikant+C%3BLee%2C+Sang-Bong%3BClogston%2C+Jeffrey+D%3BPatri%2C+Anil+K%3BBlumenthal%2C+Robert%3BCapala%2C+Jacek&rft.aulast=Puri&rft.aufirst=Anu&rft.date=2008-12-01&rft.volume=18&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Journal+of+Liposome+Research&rft.issn=08982104&rft_id=info:doi/10.1080%2F08982100802457377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug delivery; Choline; Hydrodynamics; Calcein; Lipids; Lecithin; Probes; Biochemical analysis; Atmosphere; Argon; Reducing agents; Fluorescent indicators; Vesicles; Phospholipids; Temperature effects; Physical characteristics; Leakage; Tumors; Liposomes; Antitumor agents; Sonication; Cysteine; Breast cancer; nanoparticles; Size distribution DO - http://dx.doi.org/10.1080/08982100802457377 ER - TY - JOUR T1 - Opinion: [gamma]H2AX and cancer AN - 19913467; 8800222 AB - Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus (producing [gamma]H2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may lead to cancer but, paradoxically, are also used to kill cancer cells. Using [gamma]H2AX detection to determine the extent of DSB induction may help to detect precancerous cells, to stage cancers, to monitor the effectiveness of cancer therapies and to develop novel anticancer drugs. JF - Nature Reviews: Cancer AU - Bonner, William M AU - Redon, Christophe E AU - Dickey, Jennifer S AU - Nakamura, Asako J AU - Sedelnikova, Olga A AU - Solier, Stephanie AU - Pommier, Yves AD - William M. Bonner, Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Olga A. Sedelnikova, Stephanie Solier and Yves Pommier are at the Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., bonnerw@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 957 EP - 967 PB - Nature Publishing Group, Brunel Road Houndmills Basingstoke Hampshire RG21 6XS UK, [URL:http://www.naturesj.com/sj/index.html] VL - 8 IS - 12 SN - 1474-175X, 1474-175X KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Oncogenes & Growth Factors Abstracts KW - DNA damage KW - Phosphorylation KW - Histone H2A KW - Cancer KW - Serine KW - B 26690:General, Reviews, Book Notices KW - N 14820:DNA Metabolism & Structure KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19913467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Cancer&rft.atitle=Opinion%3A+%5Bgamma%5DH2AX+and+cancer&rft.au=Bonner%2C+William+M%3BRedon%2C+Christophe+E%3BDickey%2C+Jennifer+S%3BNakamura%2C+Asako+J%3BSedelnikova%2C+Olga+A%3BSolier%2C+Stephanie%3BPommier%2C+Yves&rft.aulast=Bonner&rft.aufirst=William&rft.date=2008-12-01&rft.volume=8&rft.issue=12&rft.spage=957&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc2523 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA damage; Phosphorylation; Histone H2A; Serine; Cancer DO - http://dx.doi.org/10.1038/nrc2523 ER - TY - JOUR T1 - The Big Bang of picorna-like virus evolution antedates the radiation of eukaryotic supergroups AN - 19911787; 8820284 AB - The recent discovery of RNA viruses in diverse unicellular eukaryotes and developments in evolutionary genomics have provided the means for addressing the origin of eukaryotic RNA viruses. The phylogenetic analyses of RNA polymerases and helicases presented in this Analysis article reveal close evolutionary relationships between RNA viruses infecting hosts from the Chromalveolate and Excavate supergroups and distinct families of picorna-like viruses of plants and animals. Thus, diversification of picorna-like viruses probably occurred in a 'Big Bang' concomitant with key events of eukaryogenesis. The origins of the conserved genes of picorna-like viruses are traced to likely ancestors including bacterial group II retroelements, the family of HtrA proteases and DNA bacteriophages. JF - Nature Reviews: Microbiology AU - Koonin, Eugene V AU - Wolf, Yuri I AU - Nagasaki, Keizo AU - Dolja, Valerian V AD - National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20894, USA., doljav@science.oregonstate.edu Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 925 EP - 939 PB - Nature Publishing Co., 345 Park Ave. S. 10th Floor New York NY 10010-1707 USA, [mailto:nature@natureny.com], [URL:http://www.nature.com/nature/] VL - 6 IS - 12 SN - 1740-1526, 1740-1526 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Phages KW - Phylogeny KW - Radiation KW - Picorna-like virus KW - DNA KW - RNA viruses KW - Proteinase KW - genomics KW - Plant viruses KW - DNA helicase KW - Evolution KW - J 02310:Genetics & Taxonomy KW - G 07800:Plants and Algae KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19911787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=The+Big+Bang+of+picorna-like+virus+evolution+antedates+the+radiation+of+eukaryotic+supergroups&rft.au=Koonin%2C+Eugene+V%3BWolf%2C+Yuri+I%3BNagasaki%2C+Keizo%3BDolja%2C+Valerian+V&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2008-12-01&rft.volume=6&rft.issue=12&rft.spage=925&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro2030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phylogeny; Phages; Radiation; DNA; Proteinase; RNA viruses; genomics; Plant viruses; DNA helicase; Evolution; Picorna-like virus DO - http://dx.doi.org/10.1038/nrmicro2030 ER - TY - JOUR T1 - A fluorescence detection platform using spatial electroluminescent excitation for measuring botulinum neurotoxin A activity AN - 19892059; 8579451 AB - Current biodetection illumination technologies (laser, LED, tungsten lamp, etc.) are based on spot illumination with additional optics required when spatial excitation is required. Herein we describe a new approach of spatial illumination based on electroluminescence (EL) semiconductor strips available in several wavelengths, greatly simplifying the biosensor design by eliminating the need for additional optics. This work combines EL excitation with charge-coupled device (CCD) based detection (EL-CCD detector) of fluorescence for developing a simple portable detector for botulinum neurotoxin A (BoTN-A) activity analysis. A Forster Resonance Energy Transfer (FRET) activity assay for BoTN-A was used to both characterize and optimize the EL-CCD detector. The system consists of two modules: (1) the detection module which houses the CCD camera and emission filters, and (2) the excitation and sample module, containing the EL strip, the excitation filter and the 9-well sample chip. The FRET activity assay used in this study utilized a FITC/DABCYL-SNAP-25 peptide substrate in which cleavage of the substrate by BoTN-A, or its light chain derivative (LcA), produced an increase in fluorescence emission. EL-CCD detector measured limits of detection (LODs) were similar to those measured using a standard fluorescent plate reader with valves between 0.625 and 1.25nM (31-62ng/ml) for LcA and 0.313nM (45ng/ml) for the full toxin, BoTN-A. As far as the authors are aware this is the first demonstration of phosphor-based EL strips being used for the spatial illumination/excitation of a surface, coupled with CCD for point of care detection. JF - Biosensors and Bioelectronics AU - Sapsford, KE AU - Sun, S AU - Francis, J AU - Sharma, S AU - Kostov, Y AU - Rasooly, A AD - Office of Science and Engineering Laboratories, FDA, Silver Spring, MD 20993, USA, rasoolya@mail.nih.gov Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 618 EP - 625 PB - Elsevier Advanced Technology, 660 White Plains Rd. Tarrytown NY 10591-5153 USA VL - 24 IS - 4 SN - 0956-5663, 0956-5663 KW - Toxicology Abstracts; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Filters KW - Biosensors KW - Light chains KW - Houses KW - Illumination KW - Cameras KW - fluorescence resonance energy transfer KW - Lasers KW - Botulinum toxin type A KW - Wavelength KW - Tungsten KW - X 24390:Radioactive Materials KW - W 30955:Biosensors KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19892059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=A+fluorescence+detection+platform+using+spatial+electroluminescent+excitation+for+measuring+botulinum+neurotoxin+A+activity&rft.au=Sapsford%2C+KE%3BSun%2C+S%3BFrancis%2C+J%3BSharma%2C+S%3BKostov%2C+Y%3BRasooly%2C+A&rft.aulast=Sapsford&rft.aufirst=KE&rft.date=2008-12-01&rft.volume=24&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2008.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Biosensors; Filters; Houses; Light chains; Illumination; Cameras; fluorescence resonance energy transfer; Lasers; Wavelength; Botulinum toxin type A; Tungsten DO - http://dx.doi.org/10.1016/j.bios.2008.06.018 ER - TY - JOUR T1 - Regulation of interleukin-12-interleukin-23 production and the T-helper 17 response in humans AN - 19891780; 8783509 AB - Interleukin-12 (IL-12) and IL-23 share a common chain. Yet, their production in response to pathogens is differentially regulated, and their functions are distinct and often antithetic. IL-12 is involved in the induction or amplification of the T-helper (Th) type 1 response, whereas IL-23 has been associated with the generation of the Th17 response and IL-17 production. Mycobacterium tuberculosis and yeast zymosan induce IL-23, but in the absence of other stimuli, no IL-12 is induced in human dendritic cells (DCs). The stimulation of IL-23 by M. tuberculosis was mostly explained by the triggering of Toll-like receptor (TLR2) and the cytoplasmic receptor nucleotide oligomerization domain (NOD)-containing protein 2, whereas zymosan induces IL-23 primarily by stimulating the beta -glucan receptor dectin-1 alone or in combination with TLR2. IL-23, IL-6, transforming growth factor (TGF- beta 1), and IL-1 beta in supernatants from activated human DCs induce human naive CD4 super(+) T cells to produce IL-17. These data are consistent with various recent reports that TGF- beta is an inducer of IL-17 production both in human and in mouse cells. However, IL-1 is necessary in combination with some or all of the other cytokines to induce IL-17 production in human T cells. The ability of various stimuli to induce Th17 cells depends not only on their induction of IL-23, IL-6, and TGF- beta production in DCs but also on their ability to activate directly or indirectly the inflammasome and to induce IL-1 beta . JF - Immunological Reviews AU - Lyakh, Lyudmila AU - Trinchieri, Giorgio AU - Provezza, Lisa AU - Carra, Giuseppe AU - Gerosa, Franca AD - Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA., trinchig@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 112 EP - 131 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 226 IS - 1 SN - 0105-2896, 0105-2896 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - interleukin-12 KW - interleukin-17 KW - interleukin-23 KW - T-helper 17 KW - Mycobacterium tuberculosis KW - zymosan KW - Transforming growth factor- beta 1 KW - Interleukin 6 KW - Transforming growth factor KW - Data processing KW - Helper cells KW - TLR2 protein KW - Interleukin 1 KW - Oligomerization KW - Pathogens KW - Nucleotides KW - beta -Glucan KW - Interleukin 12 KW - Dendritic cells KW - CD4 antigen KW - Interleukin 23 KW - Interleukin 17 KW - Transforming growth factor- beta KW - Lymphocytes T KW - Tuberculosis KW - Toll-like receptors KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunological+Reviews&rft.atitle=Regulation+of+interleukin-12-interleukin-23+production+and+the+T-helper+17+response+in+humans&rft.au=Lyakh%2C+Lyudmila%3BTrinchieri%2C+Giorgio%3BProvezza%2C+Lisa%3BCarra%2C+Giuseppe%3BGerosa%2C+Franca&rft.aulast=Lyakh&rft.aufirst=Lyudmila&rft.date=2008-12-01&rft.volume=226&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Immunological+Reviews&rft.issn=01052896&rft_id=info:doi/10.1111%2Fj.1600-065X.2008.00700.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Transforming growth factor- beta 1; Transforming growth factor; Data processing; Helper cells; Oligomerization; Interleukin 1; TLR2 protein; Pathogens; Nucleotides; beta -Glucan; Dendritic cells; Interleukin 12; CD4 antigen; Interleukin 23; Interleukin 17; Transforming growth factor- beta; Lymphocytes T; Tuberculosis; Toll-like receptors; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1111/j.1600-065X.2008.00700.x ER - TY - JOUR T1 - Relapsing Fever Borreliosis in Interleukin-10-Deficient Mice AN - 19799566; 8829413 AB - Relapsing fever (RF) is a spirochetal infection characterized by periods of sickness with fever at time of high bacteremia that alternate with afebrile periods of relative well being during low bacteremia. Patients with epidemic RF who are doing relatively well have extraordinarily high levels of interleukin-10 (IL-10) in the circulation. We investigated the possibility that IL-10 plays an important protective role in this infection using wild-type and IL-10-deficient mice inoculated with virulent serotype 2 of the RF spirochete Borrelia turicatae. During peak bacteremia there was increased systemic production of IL-10 that quickly resolved in the postpeak period; in contrast, IL-6 and CXCL13 production increased during the peak but remained elevated during postpeak bacteremia. IL-10 deficiency resulted in lower bacteremia, increased specific antibody production, higher production of CXCL13 and IL-6, and thrombotic and hemorrhagic complications affecting multiple organs with secondary tissue injury. Our results revealed that production of IL-10 is highly regulated during RF and plays an important protective role in the prevention of hemorrhagic and thrombotic complications at the cost of reduced pathogen control. JF - Infection and Immunity AU - Londono, Diana AU - Marques, Adriana AU - Hornung, Ronald L AU - Cadavid, Diego AD - Department of Neurology and Neuroscience and Center for Emerging Pathogens at UMDNJ-New Jersey Medical School, Newark, New Jersey 07103. Clinical Studies Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. Clinical Services Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702 Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 5508 EP - 5513 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 12 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - Epidemics KW - Serotypes KW - Injuries KW - Borrelia burgdorferi KW - Relapsing fever KW - Bacteremia KW - Pathogens KW - Hemorrhage KW - Infection KW - Borrelia turicatae KW - Interleukin 10 KW - Fever KW - Spirochetes KW - Antibodies KW - CXCL13 protein KW - Borreliosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19799566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Relapsing+Fever+Borreliosis+in+Interleukin-10-Deficient+Mice&rft.au=Londono%2C+Diana%3BMarques%2C+Adriana%3BHornung%2C+Ronald+L%3BCadavid%2C+Diego&rft.aulast=Londono&rft.aufirst=Diana&rft.date=2008-12-01&rft.volume=76&rft.issue=12&rft.spage=5508&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Serotypes; Epidemics; Injuries; Relapsing fever; Bacteremia; Pathogens; Infection; Hemorrhage; Interleukin 10; Fever; Spirochetes; Antibodies; CXCL13 protein; Borreliosis; Borrelia burgdorferi; Borrelia turicatae ER - TY - JOUR T1 - Induction of type III secretion by cell-free Chlamydia trachomatis elementary bodies AN - 19796975; 8835747 AB - Chlamydiae secrete type III effector proteins at two distinct stages of their developmental cycle. Elementary bodies (EBs) secrete at least one pre-formed effector protein, Tarp, across the host plasma membrane from an extracellular location. Once internalized, a set of newly transcribed proteins are secreted to modify the inclusion membrane. In an effort to better understand the triggers for chlamydial type III secretion and develop means to identify new effectors, we investigated various inducers of T3SS in other Gram-negative bacterial systems to determine if they were able to activate chlamydial type III secretion from EBs using Tarp secretion as an indicator of activation. Chlamydial EBs are induced to secrete Tarp by exposure to FBS, BSA, or sphingolipid and cholesterol-rich liposomes (SCRLs). The induction by FBS and BSA, but not SCRL, is enhanced in the presence of the calcium-chelator, EGTA. This secretion was temperature dependent and inhibited by paraformaldehyde fixation of the EBs. JF - Microbial Pathogenesis AU - Jamison, W P AU - Hackstadt, T AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, 903 South Fourth Street, NIAID, NIH, Hamilton, MT 59840, USA, ted_hackstadt@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 435 EP - 440 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 45 IS - 5-6 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts B: Bacteriology KW - Temperature effects KW - Plasma membranes KW - Sphingolipids KW - Secretion KW - Chlamydia trachomatis KW - Liposomes KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19796975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Induction+of+type+III+secretion+by+cell-free+Chlamydia+trachomatis+elementary+bodies&rft.au=Jamison%2C+W+P%3BHackstadt%2C+T&rft.aulast=Jamison&rft.aufirst=W&rft.date=2008-12-01&rft.volume=45&rft.issue=5-6&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2008.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; Plasma membranes; Sphingolipids; Secretion; Liposomes; Chlamydia trachomatis DO - http://dx.doi.org/10.1016/j.micpath.2008.10.002 ER - TY - JOUR T1 - GEOmetadb: powerful alternative search engine for the Gene Expression Omnibus AN - 19795725; 8817988 AB - The NCBI Gene Expression Omnibus (GEO) represents the largest public repository of microarray data. However, finding data in GEO can be challenging. We have developed GEOmetadb in an attempt to make querying the GEO metadata both easier and more powerful. All GEO metadata records as well as the relationships between them are parsed and stored in a local MySQL database. A powerful, flexible web search interface with several convenient utilities provides query capabilities not available via NCBI tools. In addition, a Bioconductor package, GEOmetadb that utilizes a SQLite export of the entire GEOmetadb database is also available, rendering the entire GEO database accessible with full power of SQL-based queries from within R.Availability: The web interface and SQLite databases available at http://gbnci.abcc.ncifcrf.gov/geo/. The Bioconductor package is available via the Bioconductor project. The corresponding MATLAB implementation is also available at the same website. JF - Bioinformatics AU - Zhu, Yuelin AU - Davis, Sean AU - Stephens, Robert AU - Meltzer, Paul S AU - Chen, Yidong AD - 1 Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 and 2 Advanced Biomedical Computing Center, National Cancer Institute-Frederick-SAIC-Frederick Inc., Frederick, MD 21702, USA Y1 - 2008/12/01/ PY - 2008 DA - 2008 Dec 01 SP - 2798 EP - 2800 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 24 IS - 23 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Databases KW - Data processing KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19795725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=GEOmetadb%3A+powerful+alternative+search+engine+for+the+Gene+Expression+Omnibus&rft.au=Zhu%2C+Yuelin%3BDavis%2C+Sean%3BStephens%2C+Robert%3BMeltzer%2C+Paul+S%3BChen%2C+Yidong&rft.aulast=Zhu&rft.aufirst=Yuelin&rft.date=2008-12-01&rft.volume=24&rft.issue=23&rft.spage=2798&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtn520 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Databases; Data processing; Bioinformatics DO - http://dx.doi.org/10.1093/bioinformatics/btn520 ER - TY - JOUR T1 - Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection AN - 19762860; 8749288 AB - Background. Recently, a hepatitis C virus (HCV) cell-culture system was developed that employed strain JFH1 (genotype 2a), and JFH1-based intra- and intergenotypic recombinants now permit functional studies of the structural genes (Core, E1, and E2), p7, and NS2 of genotypes 1-4. The goal was to adapt the system to employ genotype 5. Methods. Huh7.5 cells infected with SA13/JFH1, containing Core-NS2 of strain SA13 (genotype 5a), were monitored for Core expression and for supernatant infectivity and HCV-RNA titers. Adaptive mutations of SA13/JFH1 were identified by sequence analysis of recovered genomes and reverse-genetic studies. Receptor blockage was performed with anti-CD81 and anti-SR-BI. For neutralization experiments, SA13/JFH1 or JFH1-based viruses of other genotypes were incubated with patient sera. Results. SA13/JFH1 with NS2 and NS3 mutations yielded infectivity titers >10 super(5) TCID sub(50)/mL. Infection with SA13/JFH1 was inhibited by CD81 blocking and SR-BI blocking, respectively, and by preincubation with genotype 5a chronic-phase patient sera. Such sera had varying cross-genotype neutralization potential. However, preincubation and treatment with homologous neutralizing antibodies could not control SA13/JFH1 infection in culture. Conclusion. The SA13/JFH1 culture permits genotype 5a- specific studies of Core-NS2 function and interfering agents. The ability of HCV to spread in vivo during treatment with neutralizing antibodies was confirmed in vitro. JF - Journal of Infectious Diseases AU - Jensen, Tanja B AU - Gottwein, Judith M AU - Scheel, Troels KH AU - Hoegh, Anne M AU - Eugen-Olsen, Jesper AU - Bukh, Jens AD - Copenhagen Hepatitis C Program, Department of Infectious Diseases and Clinical Research Centre and Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre, and Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, jbukh@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1756 EP - 1765 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 198 IS - 12 SN - 0022-1899, 0022-1899 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Recombinants KW - Genomes KW - Antibodies KW - Infectivity KW - Hepatitis C virus KW - Cell culture KW - Genotypes KW - CD81 antigen KW - Infection KW - Mutation KW - W 30925:Genetic Engineering KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19762860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Highly+Efficient+JFH1-Based+Cell-Culture+System+for+Hepatitis+C+Virus+Genotype+5a%3A+Failure+of+Homologous+Neutralizing-Antibody+Treatment+to+Control+Infection&rft.au=Jensen%2C+Tanja+B%3BGottwein%2C+Judith+M%3BScheel%2C+Troels+KH%3BHoegh%2C+Anne+M%3BEugen-Olsen%2C+Jesper%3BBukh%2C+Jens&rft.aulast=Jensen&rft.aufirst=Tanja&rft.date=2008-12-01&rft.volume=198&rft.issue=12&rft.spage=1756&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F593021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Recombinants; Infectivity; Antibodies; Cell culture; CD81 antigen; Genotypes; Infection; Mutation; Hepatitis C virus DO - http://dx.doi.org/10.1086/593021 ER - TY - JOUR T1 - Dynamic Behavior of Salmonella-Induced Membrane Tubules in Epithelial Cells AN - 19665045; 8823599 AB - Salmonella Typhimurium is a facultative intracellular pathogen that causes acute gastroenteritis in man. Intracellular Salmonella survive and replicate within a modified phagosome known as the Salmonella-containing vacuole (SCV). The onset of intracellular replication is accompanied by the appearance of membrane tubules, called Salmonella-induced filaments (Sifs), extending from the SCV. Sifs are enriched in late endosomal/lysosomal membrane proteins such as lysosome-associated membrane protein 1, but their formation and ability to interact with endosomal compartments are not characterized. In this study, we use live cell imaging techniques to define the dynamics of Sif formation in infected epithelial cells. At early time-points, Sifs are simple tubules extending from the surface of SCVs. These tubules are highly dynamic and exhibit bidirectional, microtubule-dependent movement. At the distal ends of individual Sif tubules, furthest from the SCV, a distinct 'leader' domain was often observed. At later times, Sifs develop into highly complex tubular networks that extend throughout the cell and appear less dynamic than nascent Sifs; however, individual tubules continue to display bidirectional dynamics. Sifs can acquire endocytic content by fusion, indicating a sustained interaction with the endocytic pathway. Together, these results show that these Salmonella-induced tubules form a highly dynamic network that involves both microtubule-dependent motility and interactions with endosomal compartments. JF - Traffic AU - Drecktrah, Dan AU - Levine-Wilkinson, Seamus AU - Dam, Tapen AU - Winfree, Seth AU - Knodler, Leigh A AU - Schroer, Trina A AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA Current address: Division of Biological Sciences, The University of Montana, Missoula, MT 59812, USA Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA, omortimer@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2117 EP - 2129 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 12 SN - 1398-9219, 1398-9219 KW - Microbiology Abstracts B: Bacteriology KW - confocal KW - endosomes KW - lysosomes KW - microtubule KW - Salmonella-containing vacuole KW - Sifs KW - Epithelial cells KW - Replication KW - Phagosomes KW - Membrane proteins KW - Pathogens KW - Salmonella typhimurium KW - imaging KW - Motility KW - Vacuoles KW - Gastroenteritis KW - Filaments KW - Tubules KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19665045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic&rft.atitle=Dynamic+Behavior+of+Salmonella-Induced+Membrane+Tubules+in+Epithelial+Cells&rft.au=Drecktrah%2C+Dan%3BLevine-Wilkinson%2C+Seamus%3BDam%2C+Tapen%3BWinfree%2C+Seth%3BKnodler%2C+Leigh+A%3BSchroer%2C+Trina+A%3BSteele-Mortimer%2C+Olivia&rft.aulast=Drecktrah&rft.aufirst=Dan&rft.date=2008-12-01&rft.volume=9&rft.issue=12&rft.spage=2117&rft.isbn=&rft.btitle=&rft.title=Traffic&rft.issn=13989219&rft_id=info:doi/10.1111%2Fj.1600-0854.2008.00830.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Motility; Replication; Phagosomes; Vacuoles; Pathogens; Membrane proteins; Gastroenteritis; Filaments; imaging; Tubules; Salmonella typhimurium DO - http://dx.doi.org/10.1111/j.1600-0854.2008.00830.x ER - TY - JOUR T1 - The Chlamydial Inclusion Preferentially Intercepts Basolaterally Directed Sphingomyelin-Containing Exocytic Vacuoles AN - 19662851; 8823597 AB - Chlamydiae replicate intracellularly within a unique vacuole termed the inclusion. The inclusion circumvents classical endosomal/lysosomal pathways but actively intercepts a subset of Golgi-derived exocytic vesicles containing sphingomyelin (SM) and cholesterol. To further examine this interaction, we developed a polarized epithelial cell model to study vectoral trafficking of lipids and proteins to the inclusion. We examined seven epithelial cell lines for their ability to form single monolayers of polarized cells and support chlamydial development. Of these cell lines, polarized colonic mucosal C2BBe1 cells were readily infected with Chlamydia trachomatis and remained polarized throughout infection. Trafficking of (6-((N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino)hexanoyl)sphingosine) (NBD-C sub(6)-ceramide) and its metabolic derivatives, NBD-glucosylceramide (GlcCer) and NBD-SM, was analyzed. SM was retained within L2-infected cells relative to mock-infected cells, correlating with a disruption of basolateral SM trafficking. There was no net retention of GlcCer within L2-infected cells and purification of C.trachomatis elementary bodies from polarized C2BBe1 cells confirmed that bacteria retained only SM. The chlamydial inclusion thus appears to preferentially intercept basolaterally-directed SM-containing exocytic vesicles, suggesting a divergence in SM and GlcCer trafficking. The observed changes in lipid trafficking were a chlamydia-specific effect because Coxiella burnetii-infected cells revealed no changes in GlcCer or SM polarized trafficking. JF - Traffic AU - Moore, Elizabeth R AU - Fischer, Elizabeth R AU - Mead, David J AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA Microscopy Unit, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA, thackstadt@niaid.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2130 EP - 2140 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 12 SN - 1398-9219, 1398-9219 KW - Microbiology Abstracts B: Bacteriology KW - Chlamydia KW - exocytosis KW - lipid trafficking KW - pathogenesis KW - polarized cell KW - sphingomyelin KW - Epithelial cells KW - Lipids KW - Vacuoles KW - Mucosa KW - Chlamydia trachomatis KW - Vesicles KW - Cell culture KW - Cholesterol KW - Infection KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19662851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic&rft.atitle=The+Chlamydial+Inclusion+Preferentially+Intercepts+Basolaterally+Directed+Sphingomyelin-Containing+Exocytic+Vacuoles&rft.au=Moore%2C+Elizabeth+R%3BFischer%2C+Elizabeth+R%3BMead%2C+David+J%3BHackstadt%2C+Ted&rft.aulast=Moore&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=9&rft.issue=12&rft.spage=2130&rft.isbn=&rft.btitle=&rft.title=Traffic&rft.issn=13989219&rft_id=info:doi/10.1111%2Fj.1600-0854.2008.00828.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epithelial cells; sphingomyelin; Lipids; Mucosa; Vacuoles; Cell culture; Vesicles; Cholesterol; Infection; Chlamydia trachomatis DO - http://dx.doi.org/10.1111/j.1600-0854.2008.00828.x ER - TY - JOUR T1 - Time spent with smoking parents and smoking topography in adolescents AN - 19640547; 8763767 AB - Although the relationship between parental and adolescent smoking has been linked to health consequences of smoking, limited study has explored the specific association between exposure to smoking and adolescent smoking topography (the way a cigarette is smoked). As a first step in this line of enquiry, smoking topography measures were collected from 67 adolescent dependent smokers. Participants smoked one cigarette of their own brand while being monitored by a computer-based smoking-topography unit and completed questionnaires about their time spent daily with parents who smoke Pearson's correlation analysis revealed that time spent daily with parents who smoke was significantly associated with maximum puff velocity (r=0.285, p=.019), a parameter predicting later pulmonary morbidity. ANOVAs, after a median split, were consistent with correlation analyses. There was a significant group effect on puff velocity (F(2.66)=5.197, p=.008); no significant relationship was found with puff volume (F(2.66)=.617) or puff duration (F(2.66)=.776). A post hoc Tukey HSD test indicated puff velocity was higher in the "high time spent" (M=54.37, SD=12.03) than in the "low time spent" group (M=45.59, SD=9.91) and in the group with non-smoking parents (M=44.96, SD=10.17). Future research with a larger non-treatment seeking sample of adolescents aimed at preventing tobacco smoking related diseases should further examine parental influences on adolescent smoking, including potential modeling effects. JF - Addictive Behaviors AU - Collins, C C AU - Lippmann, B M AU - Lo, S J AU - Moolchan, E T AD - Teen Tobacco Addiction Treatment Research Clinic National Institute on Drug Abuse. Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA, emoolcha@intra.nida.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1594 EP - 1597 VL - 33 IS - 12 SN - 0306-4603, 0306-4603 KW - Risk Abstracts KW - Velocity KW - Morbidity KW - group effects KW - Tobacco KW - Adolescents KW - Topography KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19640547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Time+spent+with+smoking+parents+and+smoking+topography+in+adolescents&rft.au=Collins%2C+C+C%3BLippmann%2C+B+M%3BLo%2C+S+J%3BMoolchan%2C+E+T&rft.aulast=Collins&rft.aufirst=C&rft.date=2008-12-01&rft.volume=33&rft.issue=12&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2008.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Adolescents; Topography; Velocity; group effects; Tobacco; Morbidity DO - http://dx.doi.org/10.1016/j.addbeh.2008.07.003 ER - TY - JOUR T1 - A novel approach to enhance antibody sensitivity and specificity by peptide cross-linking AN - 19585899; 8766882 AB - Most current techniques employed to improve antigen-antibody signals in Western blotting and in immunohistochemistry rely on sample processing prior to staining (e.g., microwaving) or using a more robust reporter (e.g., a secondary antibody with biotin-streptavidin). We have developed and optimized a new approach intended to stabilize the complexes formed between antigens and their respective primary antibodies by cupric ions at high pH. This technique improves the affinity and lowers cross-reactivity with nonspecific bands of approximately 20% of antibodies tested (5/25). Here we report that this method can enhance antigen- antibody specificity and can improve the utility of some poorly reactive primary antibodies. JF - Analytical Biochemistry AU - Namiki, Takeshi AU - Valencia, Julio C AU - Hall, Matthew D AU - Hearing, Vincent J AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 3132, Bethesda, MD 20814, USA, hearingv@nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 265 EP - 269 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 383 IS - 2 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Western blot KW - Antibody KW - Sensitivity KW - Specificity KW - Biuret reaction KW - Ions KW - Western blotting KW - Antibodies KW - Cross-reactivity KW - Antigen-antibody complexes KW - Immunohistochemistry KW - pH effects KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19585899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=A+novel+approach+to+enhance+antibody+sensitivity+and+specificity+by+peptide+cross-linking&rft.au=Namiki%2C+Takeshi%3BValencia%2C+Julio+C%3BHall%2C+Matthew+D%3BHearing%2C+Vincent+J&rft.aulast=Namiki&rft.aufirst=Takeshi&rft.date=2008-12-01&rft.volume=383&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2008.08.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Western blotting; Ions; Antibodies; Cross-reactivity; Antigen-antibody complexes; pH effects; Immunohistochemistry DO - http://dx.doi.org/10.1016/j.ab.2008.08.024 ER - TY - JOUR T1 - Autoinducer-2 is produced in saliva-fed flow conditions relevant to natural oral biofilms AN - 19572337; 8821930 AB - Aims:We evaluated the ability of a dual-species community of oral bacteria to produce the universal signalling molecule, autoinducer-2 (AI-2), in saliva-fed biofilms. Methods and Results:Streptococcus oralis 34, S. oralis 34 luxS mutant and Actinomyces naeslundii T14V were grown as single- and dual-species biofilms within sorbarods fed with 25% human saliva. AI-2 concentration in biofilm effluents was determined by the Vibrio harveyi BB170 bioluminescence assay. After homogenizing the sorbarods to release biofilm cells, cell numbers were determined by fluorometric analysis of fluorescent antibody-labelled cells. After 48h, dual-species biofilm communities of interdigitated S. oralis 34 and A. naeslundii T14V contained 3.210 super(9) cells: fivefold more than single-species biofilms. However, these 48-h dual-species biofilms exhibited the lowest concentration ratio of AI-2 to cell density. Conclusions:Oral bacteria produce AI-2 in saliva-fed biofilms. The decrease of more than 10-fold in concentration ratio seen between 1 and 48h in S. oralis 34-A. naeslundii T14V biofilms suggests that peak production of AI-2 occurs early and is followed by a very low steady-state level. Significance and Impact of the Study:High oral bacterial biofilm densities may be achieved by inter-species AI-2 signalling. We propose that low concentrations of AI-2 contribute to the establishment of oral commensal biofilm communities. JF - Journal of Applied Microbiology AU - Rickard, AH AU - Campagna AU - Kolenbrander, P E AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA, pkolenbrander@dir.nidcr.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 2096 EP - 2103 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 105 IS - 6 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Actinomyces naeslundii KW - autoinducer-2 KW - cell-cell signalling KW - communication KW - dual-species biofilm KW - oral bacteria KW - Streptococcus oralis KW - LuxS protein KW - Cell number KW - Bioluminescence KW - Cell density KW - Commensals KW - Vibrio harveyi KW - Effluents KW - Biofilms KW - Saliva KW - N-octanoylhomoserine lactone KW - Signal transduction KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19572337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Autoinducer-2+is+produced+in+saliva-fed+flow+conditions+relevant+to+natural+oral+biofilms&rft.au=Rickard%2C+AH%3BCampagna%3BKolenbrander%2C+P+E&rft.aulast=Rickard&rft.aufirst=AH&rft.date=2008-12-01&rft.volume=105&rft.issue=6&rft.spage=2096&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2008.03910.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - LuxS protein; Cell number; Bioluminescence; Cell density; Commensals; Saliva; Biofilms; Effluents; N-octanoylhomoserine lactone; Signal transduction; Vibrio harveyi; Actinomyces naeslundii DO - http://dx.doi.org/10.1111/j.1365-2672.2008.03910.x ER - TY - JOUR T1 - Sepsis caused by Elizabethkingia miricola successfully treated with tigecycline and levofloxacin AN - 19571106; 8835299 AB - Elizabethkingia miricola is a Gram-negative rod that was initially isolated from condensation water of the space station Mir. This is the 1st reported case of human disease caused by this organism. JF - Diagnostic Microbiology and Infectious Disease AU - Green, O AU - Murray, P AU - Gea-Banacloche, J C AD - National Institutes of Health Clinical Center, MD 20892, USA, pmurray@cc.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 430 EP - 432 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 62 IS - 4 SN - 0732-8893, 0732-8893 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Sepsis KW - tigecycline KW - Levofloxacin KW - Condensation KW - A 01490:Miscellaneous KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19571106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diagnostic+Microbiology+and+Infectious+Disease&rft.atitle=Sepsis+caused+by+Elizabethkingia+miricola+successfully+treated+with+tigecycline+and+levofloxacin&rft.au=Green%2C+O%3BMurray%2C+P%3BGea-Banacloche%2C+J+C&rft.aulast=Green&rft.aufirst=O&rft.date=2008-12-01&rft.volume=62&rft.issue=4&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Diagnostic+Microbiology+and+Infectious+Disease&rft.issn=07328893&rft_id=info:doi/10.1016%2Fj.diagmicrobio.2008.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sepsis; tigecycline; Levofloxacin; Condensation DO - http://dx.doi.org/10.1016/j.diagmicrobio.2008.07.015 ER - TY - JOUR T1 - Small membrane proteins found by comparative genomics and ribosome binding site models AN - 19568145; 8822740 AB - The correct annotation of genes encoding the smallest proteins is one of the biggest challenges of genome annotation, and perhaps more importantly, few annotated short open reading frames have been confirmed to correspond to synthesized proteins. We used sequence conservation and ribosome binding site models to predict genes encoding small proteins, defined as having 16-50 amino acids, in the intergenic regions of the Escherichia coli genome. We tested expression of these predicted as well as previously annotated genes by integrating the sequential peptide affinity tag directly upstream of the stop codon on the chromosome and assaying for synthesis using immunoblot assays. This approach confirmed that 20 previously annotated and 18 newly discovered proteins of 16-50 amino acids are synthesized. We summarize the properties of these small proteins; remarkably more than half of the proteins are predicted to be single-transmembrane proteins, nine of which we show co-fractionate with cell membranes. JF - Molecular Microbiology AU - Hemm, Matthew R AU - Paul, Brian J AU - Schneider, Thomas D AU - Storz, Gisela AU - Rudd, Kenneth E AD - Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD20892, USA., storz@helix.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 1487 EP - 1501 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 70 IS - 6 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Amino acids KW - Nucleotide sequence KW - Ribosomes KW - Membrane proteins KW - Chromosomes KW - Stop codon KW - Cell membranes KW - Reviews KW - Escherichia coli KW - Conserved sequence KW - genomics KW - Open reading frames KW - Amino acid sequence KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19568145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Small+membrane+proteins+found+by+comparative+genomics+and+ribosome+binding+site+models&rft.au=Hemm%2C+Matthew+R%3BPaul%2C+Brian+J%3BSchneider%2C+Thomas+D%3BStorz%2C+Gisela%3BRudd%2C+Kenneth+E&rft.aulast=Hemm&rft.aufirst=Matthew&rft.date=2008-12-01&rft.volume=70&rft.issue=6&rft.spage=1487&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2008.06495.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stop codon; Chromosomes; Cell membranes; Amino acids; Nucleotide sequence; Reviews; Conserved sequence; Ribosomes; Membrane proteins; genomics; Open reading frames; Amino acid sequence; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2008.06495.x ER - TY - JOUR T1 - Staphylococcus aureus Elicits Marked Alterations in the Airway Proteome during Early Pneumonia AN - 19567612; 8829451 AB - Pneumonia caused by Staphylococcus aureus is a growing concern in the health care community. We hypothesized that characterization of the early innate immune response to bacteria in the lungs would provide insight into the mechanisms used by the host to protect itself from infection. An adult mouse model of Staphylococcus aureus pneumonia was utilized to define the early events in the innate immune response and to assess the changes in the airway proteome during the first 6 h of pneumonia. S. aureus actively replicated in the lungs of mice inoculated intranasally under anesthesia to cause significant morbidity and mortality. By 6 h postinoculation, the release of proinflammatory cytokines caused effective recruitment of neutrophils to the airway. Neutrophil influx, loss of alveolar architecture, and consolidated pneumonia were observed histologically 6 h postinoculation. Bronchoalveolar lavage fluids from mice inoculated with phosphate-buffered saline (PBS) or S. aureus were depleted of overabundant proteins and subjected to strong cation exchange fractionation followed by liquid chromatography and tandem mass spectrometry to identify the proteins present in the airway. No significant changes in response to PBS inoculation or 30 min following S. aureus inoculation were observed. However, a dramatic increase in extracellular proteins was observed 6 h postinoculation with S. aureus, with the increase dominated by inflammatory and coagulation proteins. The data presented here provide a comprehensive evaluation of the rapid and vigorous innate immune response mounted in the host airway during the earliest stages of S. aureus pneumonia. JF - Infection and Immunity AU - Ventura, Christy L AU - Higdon, Roger AU - Hohmann, Laura AU - Martin, Daniel AU - Kolker, Eugene AU - Liggitt, HDenny AU - Skerrett, Shawn J AU - Rubens, Craig E AD - Division of Infectious Diseases, Center for Childhood Infections and Prematurity Research. Center for Developmental Therapeutics, Seattle Children's Hospital Research Institute. BIATECH Institute. Institute for Systems Biology. Fred Hutchinson Cancer Research Center. Departments of Pediatrics. Medical Education and Biomedical Informatics. Comparative Medicine. Medicine, University of Washington School of Medicine, Seattle, Washington. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 5862 EP - 5872 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 76 IS - 12 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mortality KW - Data processing KW - Coagulation KW - Leukocytes (neutrophilic) KW - Animal models KW - Infection KW - Alveoli KW - Mass spectroscopy KW - Morbidity KW - Inflammation KW - Anesthesia KW - Cations KW - Bronchus KW - Liquid chromatography KW - Lung KW - Inoculation KW - Cytokines KW - Immune response KW - Staphylococcus aureus KW - Pneumonia KW - Respiratory tract KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19567612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Staphylococcus+aureus+Elicits+Marked+Alterations+in+the+Airway+Proteome+during+Early+Pneumonia&rft.au=Ventura%2C+Christy+L%3BHigdon%2C+Roger%3BHohmann%2C+Laura%3BMartin%2C+Daniel%3BKolker%2C+Eugene%3BLiggitt%2C+HDenny%3BSkerrett%2C+Shawn+J%3BRubens%2C+Craig+E&rft.aulast=Ventura&rft.aufirst=Christy&rft.date=2008-12-01&rft.volume=76&rft.issue=12&rft.spage=5862&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Coagulation; Animal models; Leukocytes (neutrophilic); Infection; Morbidity; Mass spectroscopy; Alveoli; Inflammation; Anesthesia; Bronchus; Cations; Lung; Liquid chromatography; Inoculation; Cytokines; Immune response; Pneumonia; Respiratory tract; Staphylococcus aureus ER - TY - JOUR T1 - Role of hydrogen peroxide in competition and cooperation between Streptococcus gordonii and Actinomyces naeslundii AN - 19563687; 8821450 AB - In dental plaque a-haemolytic streptococci, including Streptococcus gordonii, are considered beneficial for oral health. These organisms produce hydrogen peroxide (H sub(2)O sub(2)) at concentrations sufficient to kill many oral bacteria. Streptococci do not produce catalase yet tolerate H sub(2)O sub(2). We recently demonstrated that coaggregation with Actinomyces naeslundii stabilizes arginine biosynthesis in S. gordonii. Protein arginine residues are sensitive to oxidation by H sub(2)O sub(2). Here, the ability of A. naeslundii to protect S. gordonii against self-produced H sub(2)O sub(2) was investigated. Coaggregation with A. naeslundii enabled S. gordonii to grow in the absence of arginine, and promoted survival of S. gordonii following growth with or without added arginine. Arginine-replete S. gordonii monocultures contained 20-30kM H sub(2)O sub(2) throughout exponential growth. Actinomyces naeslundii did not produce H sub(2)O sub(2) but synthesized catalase, removed H sub(2)O sub(2) from coaggregate cultures and decreased protein oxidation in S. gordonii. On solid medium, S. gordonii inhibited growth of A. naeslundii; exogenous catalase overcame this inhibition. In coaggregate cultures, A. naeslundii cell numbers were >90% lower than in monocultures after 24h. These results indicate that coaggregation with A. naeslundii protects S. gordonii from oxidative damage. However, high cell densities of S. gordonii inhibit A. naeslundii. Therefore, H sub(2)O sub(2) may drive these organisms towards an ecologically balanced community in natural dental plaque. JF - FEMS Microbiology Ecology AU - Jakubovics, Nicholas S AU - Gill, Steven R AU - Vickerman, MMargaret AU - Kolenbrander, Paul E AD - School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK, pkolenbrander@dir.nidcr.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 637 EP - 644 PB - Elsevier Science, P.O. Box 211 VL - 66 IS - 3 SN - 0168-6496, 0168-6496 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Ecology Abstracts KW - oral streptococci KW - hydrogen peroxide KW - Actinomyces naeslundii KW - metal-catalyzed oxidation KW - Streptococcus gordonii KW - catalase KW - Cell number KW - Arginine KW - Cell density KW - Survival KW - Cell culture KW - Dental plaque KW - Catalase KW - Hydrogen peroxide KW - Oxidation KW - Competition KW - A 01450:Environmental Pollution & Waste Treatment KW - D 04040:Ecosystem and Ecology Studies KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19563687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Ecology&rft.atitle=Role+of+hydrogen+peroxide+in+competition+and+cooperation+between+Streptococcus+gordonii+and+Actinomyces+naeslundii&rft.au=Jakubovics%2C+Nicholas+S%3BGill%2C+Steven+R%3BVickerman%2C+MMargaret%3BKolenbrander%2C+Paul+E&rft.aulast=Jakubovics&rft.aufirst=Nicholas&rft.date=2008-12-01&rft.volume=66&rft.issue=3&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Ecology&rft.issn=01686496&rft_id=info:doi/10.1111%2Fj.1574-6941.2008.00585.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell number; Arginine; Hydrogen peroxide; Cell density; Oxidation; Survival; Cell culture; Dental plaque; Competition; Catalase; Streptococcus gordonii; Actinomyces naeslundii DO - http://dx.doi.org/10.1111/j.1574-6941.2008.00585.x ER - TY - JOUR T1 - Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion AN - 19366881; 8752721 AB - Acute tryptophan depletion (ATD) putatively results in a transient reduction in central serotonin transmission, and induces depressed mood in some un-medicated subjects with remitted major depressive disorder (MDD). The 5-HT transporter promoter region length polymorphism (5-HTTLPR) has been shown to influence behavioral and metabolic responses to ATD, as well as the risk for developing MDD within the context of stress. The current study investigates the relationships between 5-HTTLPR genotype, neurophysiologic response to ATD, and diagnostic phenotype (healthy control subjects versus MDD subjects differentiated by their depressive response to ATD) using super(18)FDG-PET. Un-medicated subjects with remitted MDD and healthy controls were genotyped for the long (l) and short (s) alleles of the 5-HTTLPR polymorphism and categorized into one of three genotypes. On two separate occasions, subjects received either a placebo or an amino acid mixture designed to deplete plasma tryptophan, followed by super(18)FDG-PET scanning. Depressive symptoms were rated to determine the diagnostic phenotype. Descriptive and predictive discriminant analyses were performed using brain regional metabolic data to classify according to phenotype and genotype. Overall, 79% of the cases were classified correctly by genotype, and 85% were classified correctly by phenotype. In a leave-one-out cross-validation, 72% of the subjects were classified correctly as carrying an s-allele, and 79% of the subjects were classified correctly by primary diagnosis. The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category. JF - NeuroImage AU - Nugent, Allison C AU - Neumeister, Alexander AU - Goldman, David AU - Herscovitch, Peter AU - Charney, Dennis S AU - Drevets, Wayne C AD - Section on Neuroimaging in Mood and Anxiety Disorders, NIMH, NIH, Bethesda, MD, USA, nugenta@mail.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 764 EP - 774 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 43 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene polymorphism KW - Glucose metabolism KW - Mood KW - Promoters KW - Neurotransmission KW - Classification KW - Metabolic response KW - Tryptophan KW - Data processing KW - Amino acids KW - Depression KW - Brain KW - Stress KW - Serotonin KW - Scanning KW - Serotonin transporter KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Serotonin+transporter+genotype+and+depressive+phenotype+determination+by+discriminant+analysis+of+glucose+metabolism+under+acute+tryptophan+depletion&rft.au=Nugent%2C+Allison+C%3BNeumeister%2C+Alexander%3BGoldman%2C+David%3BHerscovitch%2C+Peter%3BCharney%2C+Dennis+S%3BDrevets%2C+Wayne+C&rft.aulast=Nugent&rft.aufirst=Allison&rft.date=2008-12-01&rft.volume=43&rft.issue=4&rft.spage=764&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.07.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tryptophan; Serotonin; Gene polymorphism; Depression; Glucose metabolism; Amino acids; Mood; Promoters; Metabolic response; Classification; Data processing; Brain; Scanning; Stress; Serotonin transporter; Neurotransmission DO - http://dx.doi.org/10.1016/j.neuroimage.2008.07.040 ER - TY - JOUR T1 - Dissociable roles of medial orbitofrontal cortex in human operant extinction learning AN - 19366660; 8752719 AB - Operant extinction, which features modification of instrumental responses to stimuli following a change in associated reinforcement, is an important form of learning for organisms in dynamic environments. Animal studies have highlighted orbital and medial prefrontal cortex and amygdala as mediators of operant extinction. Yet little is known about the neural mediators of operant extinction learning in humans. Using a novel fMRI paradigm, we report dissociable functional responses in distinct regions of medial orbitofrontal cortex (mOFC) during successful appetitive and aversive based operant extinction. During successful operant extinction, increased activity was observed in frontopolar OFC, while decreased activity was observed in caudal mOFC and rostral anterior cingulate cortex (rACC) relative to both (i) successful control trials where the reinforcement associated with the stimulus does not change; and (ii) successful acquisition trials during initial learning of the stimulus-reinforcement associations. Functional connectivity analysis demonstrated inverse connectivity between frontopolar OFC and both rACC and the amygdala. These data support animal models suggesting the importance of mOFC-amygdala interaction during operant extinction and expand our knowledge of the neural systems in humans. These findings suggest that in humans, frontopolar OFC modulates activity in caudal mOFC, rACC and amygdala during successful operant extinction learning. JF - NeuroImage AU - Finger, Elizabeth C AU - Mitchell, Derek GV AU - Jones, Matthew AU - Blair, RJR AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, Elizabeth.Finger@lhsc.on.ca Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 748 EP - 755 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 43 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Learning KW - Data processing KW - Extinction KW - Operant conditioning KW - Neural networks KW - Functional magnetic resonance imaging KW - Animal models KW - Cortex (cingulate) KW - Reinforcement KW - Amygdala KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Dissociable+roles+of+medial+orbitofrontal+cortex+in+human+operant+extinction+learning&rft.au=Finger%2C+Elizabeth+C%3BMitchell%2C+Derek+GV%3BJones%2C+Matthew%3BBlair%2C+RJR&rft.aulast=Finger&rft.aufirst=Elizabeth&rft.date=2008-12-01&rft.volume=43&rft.issue=4&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2008.08.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Operant conditioning; Extinction; Learning; Cortex (prefrontal); Amygdala; Neural networks; Reinforcement; Cortex (cingulate); Data processing; Animal models; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2008.08.021 ER - TY - JOUR T1 - Neural interfaces at the nanoscale AN - 1328513447; 17397537 AB - Bioelectrical neural interfaces provide a means of recording the activity from the nervous system and delivering therapeutic stimulation to restore neurological function lost during disease or injury. Although neural interfaces have reached clinical utility, reducing the size of the bioelectrical interface to minimize damage to neural tissue and maximize selectivity has proven problematic. Nanotechnology may offer a means of interfacing with the nervous system with unprecedented specificity. Emergent applications of nanotechnology to neuroscience include molecular imaging, drug delivery across the BBB, scaffolds for neural regeneration and bioelectrical interfaces. In particular, carbon nanotubes offer the promises of material stability and low electrical impedance at physical dimensions that could have a significant impact on the future on neural interfaces. The purpose of this review is to present recent advances in carbon nanotube-based bioelectrical interfaces for the nervous system and discuss research challenges and opportunities. JF - Nanomedicine AU - Pancrazio, Joseph J AD - National Institutes of Health, NINDS, 6001 Executive Boulevard, NSC/2205, Rockville, MD 20892, USA., pancrazj@ninds.nih.gov Y1 - 2008/12// PY - 2008 DA - Dec 2008 SP - 823 EP - 830 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 3 IS - 6 SN - 1743-5889, 1743-5889 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Injuries KW - Blood-brain barrier KW - Computer applications KW - Electrical impedance KW - Recovery of function KW - scaffolds KW - Nervous system KW - Carbon KW - Implants KW - Regeneration KW - nanotubes KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1328513447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Neural+interfaces+at+the+nanoscale&rft.au=Pancrazio%2C+Joseph+J&rft.aulast=Pancrazio&rft.aufirst=Joseph&rft.date=2008-12-01&rft.volume=3&rft.issue=6&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2F17435889.3.6.823 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Number of references - 70 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Drug delivery; Injuries; Blood-brain barrier; Computer applications; Recovery of function; Electrical impedance; scaffolds; Nervous system; Carbon; Implants; Regeneration; nanotubes; nanotechnology DO - http://dx.doi.org/10.2217/17435889.3.6.823 ER - TY - JOUR T1 - Mitochondrial DNA haplogroups influence AIDS progression. AN - 69773188; 19005266 AB - Mitochondrial function plays a role in both AIDS progression and HAART toxicity; therefore, we sought to determine whether mitochondrial DNA variation revealed novel AIDS restriction genes, particularly as mitochondrial DNA single-nucleotide polymorphisms are known to influence regulation of oxidative phosphorylation, reactive oxygen species production, and apoptosis. This is a retrospective cohort study. We performed an association study of mitochondrial DNA haplogroups among 1833 European American HIV-1 patients from five US cohorts: the Multicenter AIDS Cohort Study, the San Francisco City Clinic Study, Hemophilia Growth and Development Study, the Multicenter Hemophilia Cohort Study, and the AIDS Linked to Intravenous Experiences cohort to determine whether the mitochondrial DNA haplogroup correlated with AIDS progression rate. Mitochondrial DNA haplogroups J and U5a were elevated among HIV-1 infected people who display accelerated progression to AIDS and death. Haplogroups Uk, H3, and IWX appeared to be highly protective against AIDS progression. The associations found in our study appear to support a functional explanation by which mitochondrial DNA variation among haplogroups, influencing ATP production, reactive oxygen species generation, and apoptosis, is correlated to AIDS disease progression; however, repeating these results in cohorts with different ethnic backgrounds would be informative. These data suggest that mitochondrial genes are important indicators of AIDS disease progression in HIV-1 infected persons. JF - AIDS (London, England) AU - Hendrickson, Sher L AU - Hutcheson, Holli B AU - Ruiz-Pesini, Eduardo AU - Poole, Jason C AU - Lautenberger, James AU - Sezgin, Efe AU - Kingsley, Lawrence AU - Goedert, James J AU - Vlahov, David AU - Donfield, Sharyne AU - Wallace, Douglas C AU - O'Brien, Stephen J AD - Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702-1201, USA. hendricksons@mail.nih.gov Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 SP - 2429 EP - 2439 VL - 22 IS - 18 KW - DNA, Mitochondrial KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Polymorphism, Single Nucleotide KW - Humans KW - Cohort Studies KW - Adult KW - Disease Progression KW - Antiretroviral Therapy, Highly Active KW - Middle Aged KW - Male KW - Female KW - HIV-1 -- genetics KW - Haplotypes -- genetics KW - HIV-1 -- immunology KW - HIV Infections -- immunology KW - HIV Infections -- genetics KW - HIV Infections -- mortality KW - Haplotypes -- immunology KW - DNA, Mitochondrial -- immunology KW - DNA, Mitochondrial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69773188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Mitochondrial+DNA+haplogroups+influence+AIDS+progression.&rft.au=Hendrickson%2C+Sher+L%3BHutcheson%2C+Holli+B%3BRuiz-Pesini%2C+Eduardo%3BPoole%2C+Jason+C%3BLautenberger%2C+James%3BSezgin%2C+Efe%3BKingsley%2C+Lawrence%3BGoedert%2C+James+J%3BVlahov%2C+David%3BDonfield%2C+Sharyne%3BWallace%2C+Douglas+C%3BO%27Brien%2C+Stephen+J&rft.aulast=Hendrickson&rft.aufirst=Sher&rft.date=2008-11-30&rft.volume=22&rft.issue=18&rft.spage=2429&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=1473-5571&rft_id=info:doi/10.1097%2FQAD.0b013e32831940bb LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):171-6 [12509511] Vaccine. 2008 Jun 6;26(24):2951-65 [18325640] Am J Hum Genet. 2003 Apr;72(4):804-11 [12618962] Exp Gerontol. 2003 Apr;38(4):397-405 [12670626] J Med Virol. 2003 Aug;70(4):497-505 [12794710] Science. 2004 Jan 9;303(5655):223-6 [14716012] Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R9-19 [14764621] Ann N Y Acad Sci. 2003 Dec;1010:19-28 [15033690] Nat Genet. 2004 Jun;36(6):565-74 [15167933] Clin Infect Dis. 2004 Sep 1;39(5):710-6 [15356787] MMWR Morb Mortal Wkly Rep. 1987 Dec 25;36 Suppl 7:1S-20S [2826984] N Engl J Med. 1989 Oct 26;321(17):1141-8 [2477702] NIDA Res Monogr. 1991;109:75-100 [1661376] J Acquir Immune Defic Syndr. 1992;5(5):490-6 [1560346] MMWR Recomm Rep. 1992 Dec 18;41(RR-17):1-19 [1361652] Am J Pediatr Hematol Oncol. 1993 May;15(2):208-18 [8498644] FEBS Lett. 1993 Sep 27;331(1-2):182-6 [8104823] J Bioenerg Biomembr. 1994 Jun;26(3):241-50 [8077179] Am J Hum Genet. 1994 Oct;55(4):760-76 [7942855] AIDS. 1994 Aug;8(8):1123-8 [7986410] Antibiot Chemother (1971). 1996;48:4-12 [8726500] Am J Hum Genet. 1997 May;60(5):1107-21 [9150158] Science. 1997 Aug 15;277(5328):959-65 [9252328] Science. 1998 Jan 16;279(5349):389-93 [9430590] FEBS Lett. 1998 Jul 31;432(1-2):17-20 [9710242] AIDS. 1998 Oct 1;12(14):1735-44 [9792373] Cell Signal. 1999 Jan;11(1):1-14 [10206339] Lancet. 1999 Sep 25;354(9184):1112-5 [10509516] Eur J Hum Genet. 2004 Dec;12(12):1080-2 [15470367] J Acquir Immune Defic Syndr. 2004 Dec 1;37(4):1477-88 [15602126] J Exp Med. 2000 Jan 3;191(1):33-46 [10620603] Eur J Hum Genet. 2005 Aug;13(8):965-9 [15886711] AIDS. 2005 Sep 2;19(13):1341-9 [16103764] Cancer Res. 2005 Sep 1;65(17):8028-33 [16140977] Antivir Ther. 2005;10 Suppl 2:M13-27 [16152703] Nat Genet. 2005 Nov;37(11):1243-6 [16228001] Annu Rev Genet. 2005;39:359-407 [16285865] Lancet. 2005 Dec 17;366(9503):2118-21 [16360789] Am J Hum Genet. 2000 Sep;67(3):682-96 [10936107] Clin Exp Immunol. 2000 Dec;122(3):364-73 [11122242] Annu Rev Genet. 2000;34:563-591 [11092839] FASEB J. 2001 Jan;15(1):5-6 [11099484] Nat Cell Biol. 2001 Nov;3(11):E255-63 [11715037] Free Radic Biol Med. 2002 Mar 1;32(5):414-20 [11864781] Free Radic Biol Med. 2002 Jul 15;33(2):192-200 [12106815] Hum Genet. 2003 Jan;112(1):29-33 [12483296] EMBO J. 2002 Dec 16;21(24):6801-10 [12486001] Gene. 2006 Mar 1;368:21-7 [16326035] AIDS. 2006 Mar 21;20(5):675-84 [16514297] Am J Hum Genet. 2006 Apr;78(4):713-20 [16532401] J Virol. 2006 Jul;80(14):6757-63 [16809281] Nat Genet. 2006 Aug;38(8):904-9 [16862161] Int J Biochem Cell Biol. 2006;38(10):1647-53 [16766221] Nature. 2006 Oct 19;443(7113):787-95 [17051205] Hum Mutat. 2006 Nov;27(11):1072-81 [16947981] Nucleic Acids Res. 2007 Jan;35(Database issue):D823-8 [17178747] Physiol Rev. 2007 Jan;87(1):99-163 [17237344] Environ Mol Mutagen. 2007 Apr-May;48(3-4):166-72 [16758472] PLoS Genet. 2008 Jan;4(1):e236 [18208327] Annu Rev Med. 2003;54:535-51 [12525683] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/QAD.0b013e32831940bb ER - TY - CPAPER T1 - Construction of an Abdominal Probabilistic Atlas and Its Application in Automated Liver Segmentation T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41853700; 5062060 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Linguraru, Marius AU - Li, Zhixi AU - Summers, Ronald Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Liver KW - Segmentation KW - Atlases KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41853700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Construction+of+an+Abdominal+Probabilistic+Atlas+and+Its+Application+in+Automated+Liver+Segmentation&rft.au=Linguraru%2C+Marius%3BLi%2C+Zhixi%3BSummers%2C+Ronald&rft.aulast=Linguraru&rft.aufirst=Marius&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of Patient Specific CT Dosimetry Using Treatment Planning System T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41851966; 5061897 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Cheng, Jason AU - Xie, Huchen AU - Fearon, Thomas AU - Li, Guang AU - Ning, Holly AU - Arora, Barbara Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Dosimetry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Study+of+Patient+Specific+CT+Dosimetry+Using+Treatment+Planning+System&rft.au=Cheng%2C+Jason%3BXie%2C+Huchen%3BFearon%2C+Thomas%3BLi%2C+Guang%3BNing%2C+Holly%3BArora%2C+Barbara&rft.aulast=Cheng&rft.aufirst=Jason&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 3T MR Imaging of the Prostate Gland: What the Urologist Needs to Know T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41839486; 5064142 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Turkbey, Baris AU - Ravizzini, Gregory AU - Mani, Haresh AU - Bernardo, Marcelino AU - Pinto, Peter AU - Choyke, Peter Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Magnetic resonance imaging KW - Prostate KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=3T+MR+Imaging+of+the+Prostate+Gland%3A+What+the+Urologist+Needs+to+Know&rft.au=Turkbey%2C+Baris%3BRavizzini%2C+Gregory%3BMani%2C+Haresh%3BBernardo%2C+Marcelino%3BPinto%2C+Peter%3BChoyke%2C+Peter&rft.aulast=Turkbey&rft.aufirst=Baris&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Contrast-enhanced MR Imaging: A Useful Tool for Cancer Diagnosis and Monitoring of Angiogenic Inhibitor Therapy T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41831869; 5063441 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Turkbey, Baris AU - Thomasson, David AU - Bernardo, Marcelino AU - Pang, Yuxi AU - Choyke, Peter Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Cancer KW - Magnetic resonance imaging KW - Angiogenesis KW - Therapy KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41831869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Dynamic+Contrast-enhanced+MR+Imaging%3A+A+Useful+Tool+for+Cancer+Diagnosis+and+Monitoring+of+Angiogenic+Inhibitor+Therapy&rft.au=Turkbey%2C+Baris%3BThomasson%2C+David%3BBernardo%2C+Marcelino%3BPang%2C+Yuxi%3BChoyke%2C+Peter&rft.aulast=Turkbey&rft.aufirst=Baris&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optical/CT Colon Cancer Detection Probes T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41830188; 5062384 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Roney, Celeste AU - Xie, Jianwu AU - Xu, Biying AU - Griffiths, Gary AU - Summers, Ronald Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Colon cancer KW - Probes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41830188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Optical%2FCT+Colon+Cancer+Detection+Probes&rft.au=Roney%2C+Celeste%3BXie%2C+Jianwu%3BXu%2C+Biying%3BGriffiths%2C+Gary%3BSummers%2C+Ronald&rft.aulast=Roney&rft.aufirst=Celeste&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coronary Veins Imaging Utilizing Free-Breathing Whole-Heart 3D Cardiac Magnetic Resonance Imaging (MRI) at 3.0 Tesla: A Comparative Study with Multidetector Computed Tomography (MDCT) T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41801354; 5062141 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Elagha, Abdalla AU - Pettigrew, Roderic AU - Gharib, Ahmed Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Computed tomography KW - Comparative studies KW - Magnetic resonance imaging KW - Heart KW - Veins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41801354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Coronary+Veins+Imaging+Utilizing+Free-Breathing+Whole-Heart+3D+Cardiac+Magnetic+Resonance+Imaging+%28MRI%29+at+3.0+Tesla%3A+A+Comparative+Study+with+Multidetector+Computed+Tomography+%28MDCT%29&rft.au=Elagha%2C+Abdalla%3BPettigrew%2C+Roderic%3BGharib%2C+Ahmed&rft.aulast=Elagha&rft.aufirst=Abdalla&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computer-aided Detection of Polyps at Non-cathartic CTC Using Heterogeneous Stool Removal: FROC Study T2 - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AN - 41791324; 5061718 JF - 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2008) AU - Linguraru, Marius AU - Zhao, Shan AU - Van Uitert, Robert AU - Fletcher, Joel AU - Johnson, Daniel AU - Summers, Ronald Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Polyps KW - Feces KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41791324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.atitle=Computer-aided+Detection+of+Polyps+at+Non-cathartic+CTC+Using+Heterogeneous+Stool+Removal%3A+FROC+Study&rft.au=Linguraru%2C+Marius%3BZhao%2C+Shan%3BVan+Uitert%2C+Robert%3BFletcher%2C+Joel%3BJohnson%2C+Daniel%3BSummers%2C+Ronald&rft.aulast=Linguraru&rft.aufirst=Marius&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2008.rsna.org/program.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic treatment of multiple diseases in a single operating session T2 - 26th World Congress of Endourology (WCE 26) AN - 41735777; 5003225 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Papalia, Rocco AU - Leonardo, Costantino AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Laparoscopy KW - Disease control KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41735777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Laparoscopic+treatment+of+multiple+diseases+in+a+single+operating+session&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20II).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic partial nephrectomy following superselective arterial embolization T2 - 26th World Congress of Endourology (WCE 26) AN - 41712319; 5003070 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Papalia, Rocco AU - Leonardo, Costantino AU - Guaglianone, Salvatore AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Nephrectomy KW - Embolization KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41712319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Laparoscopic+partial+nephrectomy+following+superselective+arterial+embolization&rft.au=Simone%2C+Giuseppe%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BGuaglianone%2C+Salvatore%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20II).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Surgical Steps of Laparoscopic Heminephroureterectomy for a Complete Duplication of the Left Collecting System T2 - 26th World Congress of Endourology (WCE 26) AN - 41710905; 5002298 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Papalia, Rocco AU - Leonardo, Costantino AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Surgery KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41710905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Surgical+Steps+of+Laparoscopic+Heminephroureterectomy+for+a+Complete+Duplication+of+the+Left+Collecting+System&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20I).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Upper Pole Laparoscopic Resection Following Superselective Arterial Embolization T2 - 26th World Congress of Endourology (WCE 26) AN - 41701414; 5002403 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Papalia, Rocco AU - Leonardo, Costantino AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Embolization KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41701414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Upper+Pole+Laparoscopic+Resection+Following+Superselective+Arterial+Embolization&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20I).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic Nephrectomy with Enseal Device: First Experience T2 - 26th World Congress of Endourology (WCE 26) AN - 41701241; 5002367 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Loreto, Andrea AU - Guaglianone, Salvatore AU - Papalia, Rocco AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Nephrectomy KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41701241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Laparoscopic+Nephrectomy+with+Enseal+Device%3A+First+Experience&rft.au=Simone%2C+Giuseppe%3BLoreto%2C+Andrea%3BGuaglianone%2C+Salvatore%3BPapalia%2C+Rocco%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20I).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic bilateral adrenalectomy in a patient previously undergone radical cystectomy and ileal conduit T2 - 26th World Congress of Endourology (WCE 26) AN - 41685143; 5002504 JF - 26th World Congress of Endourology (WCE 26) AU - Simone, Giuseppe AU - Papalia, Rocco AU - Leonardo, Costantino AU - Loreto, Andrea AU - Gallucci, Michele Y1 - 2008/11/30/ PY - 2008 DA - 2008 Nov 30 KW - Radicals KW - Adrenalectomy KW - Laparoscopy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41685143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.atitle=Laparoscopic+bilateral+adrenalectomy+in+a+patient+previously+undergone+radical+cystectomy+and+ileal+conduit&rft.au=Simone%2C+Giuseppe%3BPapalia%2C+Rocco%3BLeonardo%2C+Costantino%3BLoreto%2C+Andrea%3BGallucci%2C+Michele&rft.aulast=Simone&rft.aufirst=Giuseppe&rft.date=2008-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+World+Congress+of+Endourology+%28WCE+26%29&rft.issn=&rft_id=info:doi/ L2 - http://www.chinamed.com.cn/wce2008/WCE%20Abstracts%20(Part%20II).pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A. AN - 69827208; 18801729 AB - Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) is a putative tumor suppressor whose expression can be increased by drug treatment. Glioblastoma is the most common central nervous system tumor, is associated with high morbidity and mortality, and responds poorly to surgical, chemical, and radiation therapy. The histone deacetylase inhibitors are under current consideration as therapeutic agents in treating glioblastoma. We investigated whether trichostatin A (TSA) would alter the expression of NAG-1 in glioblastoma cells. The DNA demethylating agent 5-aza-dC did not increase NAG-1 expression, but TSA up-regulated NAG-1 expression and acted synergistically with 5-aza-dC to induce NAG-1 expression. TSA indirectly increases NAG-1 promoter activity and increases NAG-1 mRNA and protein expression in the T98G human glioblastoma cell line. TSA also increases the expression of transcription factors Sp-1 and Egr-1. Small interfering RNA experiments link NAG-1 expression to apoptosis induced by TSA. Reporter gene assays, specific inhibition by small interfering RNA transfections, and chromatin immunoprecipitation assays indicate that Egr-1 and Sp-1 mediate TSA-induced NAG-1 expression. TSA also increases the stability of NAG-1 mRNA. TSA-induced NAG-1 expression involves multiple mechanisms at the transcriptional and post-transcriptional levels. JF - The Journal of biological chemistry AU - Yoshioka, Hiroki AU - Kamitani, Hideki AU - Watanabe, Takashi AU - Eling, Thomas E AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/11/28/ PY - 2008 DA - 2008 Nov 28 SP - 33129 EP - 33137 VL - 283 IS - 48 SN - 0021-9258, 0021-9258 KW - EGR1 protein, human KW - 0 KW - Early Growth Response Protein 1 KW - Enzyme Inhibitors KW - GDF15 protein, human KW - Growth Differentiation Factor 15 KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - Neoplasm Proteins KW - RNA, Messenger KW - RNA, Neoplasm KW - RNA, Small Interfering KW - Sp1 Transcription Factor KW - trichostatin A KW - 3X2S926L3Z KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - RNA, Neoplasm -- biosynthesis KW - Azacitidine -- pharmacology KW - Early Growth Response Protein 1 -- metabolism KW - Humans KW - Azacitidine -- analogs & derivatives KW - Up-Regulation -- drug effects KW - Sp1 Transcription Factor -- metabolism KW - RNA, Small Interfering -- pharmacology KW - Cell Line, Tumor KW - RNA, Messenger -- biosynthesis KW - Neoplasm Proteins -- biosynthesis KW - Neoplasm Proteins -- antagonists & inhibitors KW - Growth Differentiation Factor 15 -- antagonists & inhibitors KW - Glioblastoma -- metabolism KW - Growth Differentiation Factor 15 -- biosynthesis KW - Enzyme Inhibitors -- pharmacology KW - Hydroxamic Acids -- pharmacology KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69827208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Nonsteroidal+anti-inflammatory+drug-activated+gene+%28NAG-1%2FGDF15%29+expression+is+increased+by+the+histone+deacetylase+inhibitor+trichostatin+A.&rft.au=Yoshioka%2C+Hiroki%3BKamitani%2C+Hideki%3BWatanabe%2C+Takashi%3BEling%2C+Thomas+E&rft.aulast=Yoshioka&rft.aufirst=Hiroki&rft.date=2008-11-28&rft.volume=283&rft.issue=48&rft.spage=33129&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M805248200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-29 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Dec 1;20(23):8597-603 [11102463] Mol Cancer. 2007;6:36 [17547775] J Comp Neurol. 2001 Oct 8;439(1):32-45 [11579380] J Biol Chem. 2001 Nov 9;276(45):42084-90 [11551946] J Clin Oncol. 2002 Mar 1;20(5):1375-82 [11870182] Carcinogenesis. 2002 Mar;23(3):425-34 [11895857] J Biol Chem. 2002 May 10;277(19):16823-30 [11877441] J Pharmacol Exp Ther. 2002 Jun;301(3):1126-31 [12023546] Biochem Biophys Res Commun. 2002 Jul 5;295(1):187-92 [12083788] Circ Res. 2002 Nov 1;91(9):837-44 [12411399] Br J Cancer. 2002 Oct 21;87(9):1042-6 [12434298] Mol Pharmacol. 2003 Mar;63(3):557-64 [12606762] Nucleic Acids Res. 2003 Mar 15;31(6):1693-703 [12626711] Int J Cancer. 2003 Jul 20;105(6):747-53 [12767058] Oncogene. 2003 Sep 4;22(38):6023-31 [12955081] J Biol Chem. 2004 Feb 20;279(8):6883-92 [14662774] Carcinogenesis. 2004 Oct;25(10):1813-20 [15142888] J Biol Chem. 1979 Mar 10;254(5):1716-23 [762168] J Biol Chem. 1993 Oct 25;268(30):22429-35 [8226751] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5705-8 [8650156] Nature. 1997 Sep 25;389(6649):349-52 [9311776] Cell. 1998 Feb 20;92(4):463-73 [9491888] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3356-61 [9520369] Exp Cell Res. 1998 May 25;241(1):126-33 [9633520] Nat Genet. 1999 Jan;21(1):103-7 [9916800] Curr Opin Genet Dev. 1999 Feb;9(1):40-8 [10072350] Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4592-7 [10200307] Oncogene. 1999 Apr 15;18(15):2461-70 [10229197] Mol Cell Biol. 1999 Aug;19(8):5504-11 [10409740] Mol Pharmacol. 2005 Feb;67(2):356-64 [15509713] Biochem Biophys Res Commun. 2005 Mar 4;328(1):63-9 [15670751] Acta Neuropathol. 2005 Jan;109(1):93-108 [15685439] Prostate. 2008 Feb 1;68(2):210-22 [18092350] Br J Pharmacol. 2008 Feb;153(4):657-68 [18059320] J Cell Mol Med. 2008 Apr;12(2):607-21 [18419600] Breast Cancer Res Treat. 2008 Sep;111(1):15-25 [17891453] Cancer Lett. 2008 Oct 18;270(1):30-9 [18550273] J Biol Chem. 2005 Sep 23;280(38):32569-77 [15994313] Mol Cancer Ther. 2005 Oct;4(10):1551-8 [16227405] Prog Lipid Res. 2006 Jan;45(1):1-16 [16337272] Mol Cancer Ther. 2006 May;5(5):1352-61 [16731769] J Pharmacol Exp Ther. 2006 Aug;318(2):899-906 [16714403] Gastroenterology. 2006 Nov;131(5):1553-60 [17101328] J Biochem Mol Biol. 2006 Nov 30;39(6):649-55 [17129398] J Biol Chem. 2007 Feb 16;282(7):4765-71 [17121856] Cancer. 2007 Apr 15;109(8):1676-88 [17330857] J Biol Chem. 2001 Sep 7;276(36):33384-92 [11445565] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M805248200 ER - TY - JOUR T1 - Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site. AN - 69826085; 18805795 AB - Pigment epithelium-derived factor (PEDF) is a multifunctional serpin with antitumorigenic, antimetastatic, and differentiating activities. PEDF is found within tissues rich in the glycosaminoglycan hyaluronan (HA), and its amino acid sequence contains putative HA-binding motifs. We show that PEDF coprecipitation with glycosaminoglycans in media conditioned by human retinoblastoma Y-79 cells decreased after pretreatments with hyaluronidase, implying an association between HA and PEDF. Direct binding of human recombinant PEDF to highly purified HA was demonstrated by coprecipitation in the presence of cetylpyridinium chloride. Binding of PEDF to HA was concentration-dependent and saturable. The PEDF-HA interactions were sensitive to increasing NaCl concentrations, indicating an ionic nature of these interactions and having affinity higher than PEDF-heparin. Competition assays showed that PEDF can bind heparin and HA simultaneously. PEDF chemically modified with fluorescein retained the capacity for interacting with HA but lacked heparin affinity, suggesting one or more distinct HA-binding regions on PEDF. The HA-binding region was examined by site-directed mutagenesis. Single-point and cumulative alterations at basic residues within the putative HA-binding motif K189A/K191A/R194A/K197A drastically reduced the HA-binding activity without affecting heparin- or collagen I binding of PEDF. Cumulative alterations at sites critical for heparin binding (K146A/K147A/R149A) decreased HA affinity but not collagen I binding. Thus these clusters of basic residues (BXBXXBXXB and BX3AB2XB motifs) in PEDF are functional regions for binding HA. In the spatial PEDF structure they are located in distinct areas away from the collagen-binding site. The HA-binding activity of PEDF may contribute to deposition in the extracellular matrix and to its reported antitumor/antimetastatic effects. JF - The Journal of biological chemistry AU - Becerra, S Patricia AU - Perez-Mediavilla, L Alberto AU - Weldon, John E AU - Locatelli-Hoops, Silvia AU - Senanayake, Preenie AU - Notari, Luigi AU - Notario, Vicente AU - Hollyfield, Joe G AD - NEI, National Institutes of Health, Bethesda, Maryland 20892, USA. becerrap@nei.nih.gov Y1 - 2008/11/28/ PY - 2008 DA - 2008 Nov 28 SP - 33310 EP - 33320 VL - 283 IS - 48 SN - 0021-9258, 0021-9258 KW - Eye Proteins KW - 0 KW - Nerve Growth Factors KW - Serpins KW - pigment epithelium-derived factor KW - Hyaluronic Acid KW - 9004-61-9 KW - Heparin KW - 9005-49-6 KW - Index Medicus KW - Rats KW - Mutagenesis, Site-Directed KW - Protein Binding -- physiology KW - Animals KW - Amino Acid Motifs -- physiology KW - Humans KW - Organ Specificity -- physiology KW - Heparin -- metabolism KW - Heparin -- chemistry KW - Cell Line, Tumor KW - Amino Acid Substitution KW - Cricetinae KW - Nerve Growth Factors -- metabolism KW - Extracellular Matrix -- metabolism KW - Peptide Mapping KW - Eye Proteins -- chemistry KW - Eye Proteins -- metabolism KW - Serpins -- chemistry KW - Hyaluronic Acid -- chemistry KW - Hyaluronic Acid -- metabolism KW - Extracellular Matrix -- chemistry KW - Nerve Growth Factors -- genetics KW - Nerve Growth Factors -- chemistry KW - Eye Proteins -- genetics KW - Serpins -- metabolism KW - Serpins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69826085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Pigment+epithelium-derived+factor+binds+to+hyaluronan.+Mapping+of+a+hyaluronan+binding+site.&rft.au=Becerra%2C+S+Patricia%3BPerez-Mediavilla%2C+L+Alberto%3BWeldon%2C+John+E%3BLocatelli-Hoops%2C+Silvia%3BSenanayake%2C+Preenie%3BNotari%2C+Luigi%3BNotario%2C+Vicente%3BHollyfield%2C+Joe+G&rft.aulast=Becerra&rft.aufirst=S&rft.date=2008-11-28&rft.volume=283&rft.issue=48&rft.spage=33310&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M801287200 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-29 N1 - Date created - 2008-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11131-5 [11562499] J Biol Chem. 2007 Mar 2;282(9):6661-7 [17202143] J Cell Sci. 2001 Dec;114(Pt 24):4421-8 [11792807] J Biol Chem. 2002 Feb 15;277(7):4593-6 [11717318] J Biol Chem. 2002 Feb 15;277(7):4575-9 [11717319] Trends Mol Med. 2002 Jul;8(7):330-4 [12114112] J Biol Chem. 2002 Nov 22;277(47):45400-7 [12237317] BMC Biochem. 2003 Feb 19;4:1 [12625842] Biochemistry. 2003 Mar 25;42(11):3160-7 [12641447] Nat Med. 2003 Jun;9(6):774-80 [12740569] Mol Ther. 2003 Jul;8(1):72-9 [12842430] Nat Rev Neurosci. 2003 Aug;4(8):628-36 [12894238] Cancer Res. 2003 Sep 15;63(18):5685-90 [14522884] J Biol Chem. 1999 Oct 29;274(44):31605-12 [10531367] Invest Ophthalmol Vis Sci. 1999 Nov;40(12):2767-9 [10549633] Glycobiology. 2000 Mar;10(3):273-81 [10704526] Glycobiology. 2000 Mar;10(3):283-93 [10704527] J Cell Sci. 2001 Jan;114(Pt 1):199-205 [11112703] Exp Eye Res. 2004 Feb;78(2):223-34 [14729355] J Biol Chem. 2004 May 28;279(22):23142-50 [15044457] Cell. 1977 May;11(1):223-32 [194704] Ciba Found Symp. 1989;143:150-9; discussion 159-69, 281-5 [2680343] Biochemistry. 1989 Nov 14;28(23):8951-66 [2690952] Exp Eye Res. 1991 Sep;53(3):411-4 [1936177] J Cell Biol. 1992 Jan;116(2):545-57 [1730767] J Exp Med. 1992 Aug 1;176(2):623-7 [1500863] Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1526-30 [8434014] Cancer Res. 1994 Jan 15;54(2):422-6 [7506122] Growth Factors. 1994;10(4):289-97 [7803045] Protein Expr Purif. 1995 Aug;6(4):447-56 [8527930] Am J Pathol. 1996 Jun;148(6):1721-6 [8669457] J Exp Med. 1996 Apr 1;183(4):1663-8 [8666924] Invest Ophthalmol Vis Sci. 1996 Sep;37(10):1984-93 [8814138] Protein Sci. 1996 Dec;5(12):2575-82 [8976566] Invest Ophthalmol Vis Sci. 1996 Dec;37(13):2759-67 [8977492] Exp Eye Res. 1997 Nov;65(5):603-8 [9367640] Arch Biochem Biophys. 1998 Feb 1;350(1):26-35 [9466816] J Biol Chem. 1998 Jun 12;273(24):15125-30 [9614124] Exp Eye Res. 1998 Feb;66(2):241-8 [9533850] Biochim Biophys Acta. 1998 Jun 16;1398(2):203-14 [9689919] Biochemistry. 1998 Jul 28;37(30):10643-52 [9692954] J Biol Chem. 1998 Nov 20;273(47):31599-606 [9813076] Glycobiology. 1998 Dec;8(12):1227-35 [9858645] J Pediatr Surg. 2005 Jan;40(1):236-43 [15868591] Cancer Res. 2005 Jun 15;65(12):5144-52 [15958558] Biochem Biophys Res Commun. 2005 Sep 30;335(3):756-61 [16102727] Curr Drug Targets. 2005 Sep;6(6):665-82 [16178800] Exp Eye Res. 2006 May;82(5):739-40 [16364294] Cancer Res. 2006 Nov 1;66(21):10233-7 [17079438] J Mol Med (Berl). 2007 Jan;85(1):15-22 [17106733] Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3287-93 [11726635] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/jbc.M801287200 ER - TY - JOUR T1 - PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release AN - 19592434; 8820334 AB - Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of tuberculosis. These prodrugs require intracellular activation for their biological function. We found that Rv3547 is a deazaflavin-dependent nitroreductase (Ddn) that converts PA-824 into three primary metabolites; the major one is the corresponding des-nitroimidazole (des-nitro). When derivatives of PA-824 were used, the amount of des-nitro metabolite formed was highly correlated with anaerobic killing of Mycobacterium tuberculosis (Mtb). Des-nitro metabolite formation generated reactive nitrogen species, including nitric oxide (NO), which are the major effectors of the anaerobic activity of these compounds. Furthermore, NO scavengers protected the bacilli from the lethal effects of the drug. Thus, these compounds may act as intracellular NO donors and could augment a killing mechanism intrinsic to the innate immune system. JF - Science (Washington) AU - Singh, Ramandeep AU - Manjunatha, Ujjini AU - Boshoff, Helena IM AU - Ha, Young Hwan AU - Niyomrattanakit, Pornwaratt AU - Ledwidge, Richard AU - Dowd, Cynthia S AU - Lee, Ill Young AU - Kim, Pilho AU - Zhang, Liang AU - Kang, Sunhee AU - Keller, Thomas H AU - Jiricek, Jan AU - Barry, Clifton E 3rd AD - Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA., cbarry@mail.nih.gov Y1 - 2008/11/28/ PY - 2008 DA - 2008 Nov 28 SP - 1392 EP - 1395 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 322 IS - 5906 SN - 0036-8075, 0036-8075 KW - Microbiology Abstracts B: Bacteriology KW - Nitroreductase KW - Bacilli KW - prodrugs KW - Immune system KW - nitroimidazoles KW - Nitric oxide KW - Metabolites KW - Tuberculosis KW - reactive nitrogen species KW - Immunosuppressive agents KW - Mycobacterium tuberculosis KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19592434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=PA-824+Kills+Nonreplicating+Mycobacterium+tuberculosis+by+Intracellular+NO+Release&rft.au=Singh%2C+Ramandeep%3BManjunatha%2C+Ujjini%3BBoshoff%2C+Helena+IM%3BHa%2C+Young+Hwan%3BNiyomrattanakit%2C+Pornwaratt%3BLedwidge%2C+Richard%3BDowd%2C+Cynthia+S%3BLee%2C+Ill+Young%3BKim%2C+Pilho%3BZhang%2C+Liang%3BKang%2C+Sunhee%3BKeller%2C+Thomas+H%3BJiricek%2C+Jan%3BBarry%2C+Clifton+E+3rd&rft.aulast=Singh&rft.aufirst=Ramandeep&rft.date=2008-11-28&rft.volume=322&rft.issue=5906&rft.spage=1392&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1164571 L2 - http://www.sciencemag.org/cgi/reprint/322/5906/1392.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nitroreductase; Bacilli; prodrugs; Immune system; nitroimidazoles; reactive nitrogen species; Tuberculosis; Metabolites; Nitric oxide; Immunosuppressive agents; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1126/science.1164571 ER - TY - JOUR T1 - Stromal gene signatures in large-B-cell lymphomas. AN - 69834606; 19038878 AB - The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma. Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear. We profiled gene expression in pretreatment biopsy specimens from 181 patients with diffuse large-B-cell lymphoma who received CHOP and 233 patients with this disease who received R-CHOP. A multivariate gene-expression-based survival-predictor model derived from a training group was tested in a validation group. A multivariate model created from three gene-expression signatures--termed "germinal-center B-cell," "stromal-1," and "stromal-2"--predicted survival both in patients who received CHOP and patients who received R-CHOP. The prognostically favorable stromal-1 signature reflected extracellular-matrix deposition and histiocytic infiltration. By contrast, the prognostically unfavorable stromal-2 signature reflected tumor blood-vessel density. Survival after treatment of diffuse large-B-cell lymphoma is influenced by differences in immune cells, fibrosis, and angiogenesis in the tumor microenvironment. 2008 Massachusetts Medical Society JF - The New England journal of medicine AU - Lenz, G AU - Wright, G AU - Dave, S S AU - Xiao, W AU - Powell, J AU - Zhao, H AU - Xu, W AU - Tan, B AU - Goldschmidt, N AU - Iqbal, J AU - Vose, J AU - Bast, M AU - Fu, K AU - Weisenburger, D D AU - Greiner, T C AU - Armitage, J O AU - Kyle, A AU - May, L AU - Gascoyne, R D AU - Connors, J M AU - Troen, G AU - Holte, H AU - Kvaloy, S AU - Dierickx, D AU - Verhoef, G AU - Delabie, J AU - Smeland, E B AU - Jares, P AU - Martinez, A AU - Lopez-Guillermo, A AU - Montserrat, E AU - Campo, E AU - Braziel, R M AU - Miller, T P AU - Rimsza, L M AU - Cook, J R AU - Pohlman, B AU - Sweetenham, J AU - Tubbs, R R AU - Fisher, R I AU - Hartmann, E AU - Rosenwald, A AU - Ott, G AU - Muller-Hermelink, H-K AU - Wrench, D AU - Lister, T A AU - Jaffe, E S AU - Wilson, W H AU - Chan, W C AU - Staudt, L M AU - Lymphoma/Leukemia Molecular Profiling Project AD - Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. ; Lymphoma/Leukemia Molecular Profiling Project Y1 - 2008/11/27/ PY - 2008 DA - 2008 Nov 27 SP - 2313 EP - 2323 VL - 359 IS - 22 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Murine-Derived KW - Immunologic Factors KW - Rituximab KW - 4F4X42SYQ6 KW - Vincristine KW - 5J49Q6B70F KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Abridged Index Medicus KW - Index Medicus KW - Extracellular Matrix -- genetics KW - Immunologic Factors -- administration & dosage KW - Humans KW - Prognosis KW - Disease Progression KW - Antibodies, Monoclonal -- administration & dosage KW - Multivariate Analysis KW - Kaplan-Meier Estimate KW - Gene Expression Regulation, Neoplastic KW - Germinal Center KW - Neovascularization, Pathologic -- genetics KW - Antineoplastic Combined Chemotherapy Protocols KW - Middle Aged KW - Genes, MHC Class II KW - Gene Expression Profiling KW - Lymphoma, Large B-Cell, Diffuse -- mortality KW - Lymphoma, Large B-Cell, Diffuse -- drug therapy KW - Lymphoma, Large B-Cell, Diffuse -- pathology KW - Gene Expression KW - Stromal Cells -- metabolism KW - Stromal Cells -- pathology KW - Lymphoma, Large B-Cell, Diffuse -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69834606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Stromal+gene+signatures+in+large-B-cell+lymphomas.&rft.au=Lenz%2C+G%3BWright%2C+G%3BDave%2C+S+S%3BXiao%2C+W%3BPowell%2C+J%3BZhao%2C+H%3BXu%2C+W%3BTan%2C+B%3BGoldschmidt%2C+N%3BIqbal%2C+J%3BVose%2C+J%3BBast%2C+M%3BFu%2C+K%3BWeisenburger%2C+D+D%3BGreiner%2C+T+C%3BArmitage%2C+J+O%3BKyle%2C+A%3BMay%2C+L%3BGascoyne%2C+R+D%3BConnors%2C+J+M%3BTroen%2C+G%3BHolte%2C+H%3BKvaloy%2C+S%3BDierickx%2C+D%3BVerhoef%2C+G%3BDelabie%2C+J%3BSmeland%2C+E+B%3BJares%2C+P%3BMartinez%2C+A%3BLopez-Guillermo%2C+A%3BMontserrat%2C+E%3BCampo%2C+E%3BBraziel%2C+R+M%3BMiller%2C+T+P%3BRimsza%2C+L+M%3BCook%2C+J+R%3BPohlman%2C+B%3BSweetenham%2C+J%3BTubbs%2C+R+R%3BFisher%2C+R+I%3BHartmann%2C+E%3BRosenwald%2C+A%3BOtt%2C+G%3BMuller-Hermelink%2C+H-K%3BWrench%2C+D%3BLister%2C+T+A%3BJaffe%2C+E+S%3BWilson%2C+W+H%3BChan%2C+W+C%3BStaudt%2C+L+M%3BLymphoma%2FLeukemia+Molecular+Profiling+Project&rft.aulast=Lenz&rft.aufirst=G&rft.date=2008-11-27&rft.volume=359&rft.issue=22&rft.spage=2313&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMoa0802885 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-04 N1 - Date created - 2008-11-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 2009 Jun 25;360(26):2794-5 [19553658] N Engl J Med. 2008 Nov 27;359(22):2379-81 [19038884] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1056/NEJMoa0802885 ER - TY - JOUR T1 - Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. AN - 66692353; 18973327 AB - O(6)-Benzylguanine is an irreversible inactivator of O(6)-alkylguanine-DNA alkyltransferase currently in clinical trials to overcome alkyltransferase-mediated resistance to certain cancer chemotherapeutic alkylating agents. In order to produce more soluble alkyltransferase inhibitors, we have synthesized three aminomethyl-substituted O(6)-benzylguanines and the three methyl analogs and found that the substitution of aminomethyl at the meta-position greatly enhances inactivation of alkyltransferase, whereas para-substitution has little effect and ortho-substitution virtually eliminates activity. Molecular modeling of their interactions with alkyltransferase provided a molecular explanation for these results. The square of the correlation coefficient (R(2)) obtained between E-model scores (obtained from GLIDE XP/QPLD docking calculations) vs log(ED(50)) values via a linear regression analysis was 0.96. The models indicate that the ortho-substitution causes a steric clash interfering with binding, whereas the meta-aminomethyl substitution allows an interaction of the amino group to generate an additional hydrogen bond with the protein. JF - Journal of medicinal chemistry AU - Pauly, Gary T AU - Loktionova, Natalia A AU - Fang, Qingming AU - Vankayala, Sai Lakshmana AU - Guida, Wayne C AU - Pegg, Anthony E AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, P.O. Box B, Building 538, Frederick, Maryland 21702, USA. Y1 - 2008/11/27/ PY - 2008 DA - 2008 Nov 27 SP - 7144 EP - 7153 VL - 51 IS - 22 KW - Enzyme Inhibitors KW - 0 KW - Ligands KW - O(6)-benzylguanine KW - 01KC87F8FE KW - Guanine KW - 5Z93L87A1R KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Index Medicus KW - Molecular Structure KW - Stereoisomerism KW - Computer Simulation KW - Models, Molecular KW - Humans KW - Models, Chemical KW - Hydrogen Bonding KW - Structure-Activity Relationship KW - O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors KW - Guanine -- chemistry KW - Enzyme Inhibitors -- chemistry KW - Enzyme Inhibitors -- pharmacology KW - Guanine -- chemical synthesis KW - Guanine -- analogs & derivatives KW - Enzyme Inhibitors -- chemical synthesis KW - Guanine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66692353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Substitution+of+aminomethyl+at+the+meta-position+enhances+the+inactivation+of+O6-alkylguanine-DNA+alkyltransferase+by+O6-benzylguanine.&rft.au=Pauly%2C+Gary+T%3BLoktionova%2C+Natalia+A%3BFang%2C+Qingming%3BVankayala%2C+Sai+Lakshmana%3BGuida%2C+Wayne+C%3BPegg%2C+Anthony+E&rft.aulast=Pauly&rft.aufirst=Gary&rft.date=2008-11-27&rft.volume=51&rft.issue=22&rft.spage=7144&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Fjm800675p LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-03 N1 - Date created - 2009-02-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 1999 Dec;291(3):1269-75 [10565851] Neuro Oncol. 2008 Jun;10(3):320-9 [18403491] EMBO J. 2000 Apr 3;19(7):1719-30 [10747039] Mutat Res. 2000 Apr;462(2-3):83-100 [10767620] J Med Chem. 2000 Nov 2;43(22):4071-83 [11063604] Biochem J. 2000 Apr 15;347(Pt 2):519-26 [10749682] J Pharmacol Exp Ther. 2001 Mar;296(3):958-65 [11181929] Biochemistry. 2002 Jul 9;41(27):8689-97 [12093287] Nat Biotechnol. 2003 Jan;21(1):86-9 [12469133] Lancet Oncol. 2003 Jan;4(1):37-44 [12517538] Carcinogenesis. 2003 Apr;24(4):625-35 [12727789] Biochemistry. 2003 Sep 23;42(37):10965-70 [12974631] J Med Chem. 2004 Mar 25;47(7):1683-93 [15027859] J Med Chem. 2004 Mar 25;47(7):1739-49 [15027865] J Med Chem. 2004 Mar 25;47(7):1750-9 [15027866] Nat Rev Cancer. 2004 Apr;4(4):296-307 [15057289] J Med Chem. 2004 Jul 15;47(15):3887-91 [15239666] Nat Struct Mol Biol. 2004 Aug;11(8):714-20 [15221026] Proc Natl Acad Sci U S A. 1990 Jul;87(14):5368-72 [2164681] Cancer Res. 1991 Jul 1;51(13):3367-72 [1647266] J Med Chem. 1992 Nov 13;35(23):4486-91 [1447749] Biochemistry. 1993 Nov 16;32(45):11998-2006 [8218276] Biochemistry. 1994 Jul 19;33(28):8385-90 [8031773] J Biol Chem. 1995 Mar 10;270(10):5375-80 [7534295] Biochem Pharmacol. 1997 May 15;53(10):1559-64 [9260884] J Med Chem. 1998 Dec 17;41(26):5265-71 [9857094] Clin Cancer Res. 1997 Jun;3(6):837-47 [9815757] Bioorg Med Chem. 2005 Jun 1;13(11):3821-39 [15863008] J Comput Chem. 2005 Jul 15;26(9):915-31 [15841474] J Clin Oncol. 2005 Oct 1;23(28):7178-87 [16192602] J Clin Oncol. 2005 Oct 20;23(30):7646-53 [16234526] Clin Cancer Res. 2005 Nov 1;11(21):7861-5 [16278409] Clin Cancer Res. 2006 Mar 1;12(5):1577-84 [16533784] Neurol Res. 2006 Jul;28(5):542-8 [16808887] J Med Chem. 2006 Oct 19;49(21):6177-96 [17034125] Curr Drug Deliv. 2007 Apr;4(2):169-80 [17456036] Cancer Chemother Pharmacol. 2007 Aug;60(3):415-21 [17354015] DNA Repair (Amst). 2007 Aug 1;6(8):1100-15 [17485252] Expert Opin Investig Drugs. 2007 Oct;16(10):1573-84 [17922622] J Med Chem. 2007 Oct 18;50(21):5193-201 [17880193] Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6712-8 [18006772] Biochem Pharmacol. 2008 Feb 1;75(3):618-26 [17996846] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jm800675p ER - TY - JOUR T1 - A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. AN - 69794523; 18951897 AB - We identified a novel inhibitor of growth family member 2 (ING2) isoform, ING2b, which shares exon 2 with ING2a, but lacks the N-terminal p53 binding region. Contrary to ING2a, ING2b's promoter has no p53 binding sites. Consistently, activation of p53 led to suppression of ING2a, leaving ING2b unaffected. Through isoform-specific targeting, we showed that ING2a knockdown suppressed cell growth only in the presence of p53, ING2b knockdown had no effect on cell growth, and knockdown of both induced cell cycle arrest and apoptosis independently of p53. ING2a and ING2b have compensatory roles that protect cells from cell cycle arrest and apoptosis and may be involved in development of chemotherapeutic resistance. JF - FEBS letters AU - Unoki, Motoko AU - Kumamoto, Kensuke AU - Robles, Ana I AU - Shen, Jiang Cheng AU - Zheng, Zhi-Ming AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr., Bldg. 37, Rm. 3068, Bethesda, MD 20892, USA. Y1 - 2008/11/26/ PY - 2008 DA - 2008 Nov 26 SP - 3868 EP - 3874 VL - 582 IS - 28 SN - 0014-5793, 0014-5793 KW - Homeodomain Proteins KW - 0 KW - ING2 protein, human KW - Protein Isoforms KW - Receptors, Cytoplasmic and Nuclear KW - Tumor Suppressor Protein p53 KW - Tumor Suppressor Proteins KW - Index Medicus KW - Animals KW - Promoter Regions, Genetic KW - Gene Knockdown Techniques KW - Protein Isoforms -- metabolism KW - Humans KW - Molecular Sequence Data KW - Mice KW - Gene Expression Regulation KW - Amino Acid Sequence KW - Protein Isoforms -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Cell Line KW - Binding Sites KW - Apoptosis -- genetics KW - Homeodomain Proteins -- genetics KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Homeodomain Proteins -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Cell Cycle -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69794523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=A+novel+ING2+isoform%2C+ING2b%2C+synergizes+with+ING2a+to+prevent+cell+cycle+arrest+and+apoptosis.&rft.au=Unoki%2C+Motoko%3BKumamoto%2C+Kensuke%3BRobles%2C+Ana+I%3BShen%2C+Jiang+Cheng%3BZheng%2C+Zhi-Ming%3BHarris%2C+Curtis+C&rft.aulast=Unoki&rft.aufirst=Motoko&rft.date=2008-11-26&rft.volume=582&rft.issue=28&rft.spage=3868&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2008.10.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-02 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2001 May 15;29(10):2052-8 [11353074] Oncogene. 2003 Apr 10;22(14):2172-85 [12687019] Cancer Res. 2003 May 15;63(10):2373-8 [12750254] Mol Cell. 2006 Jan 6;21(1):51-64 [16387653] FEBS Lett. 2006 Jul 10;580(16):3787-93 [16782091] Int J Cancer. 2008 Oct 1;123(7):1483-90 [18636562] Nature. 2006 Jul 6;442(7098):100-3 [16728977] J Biol Chem. 2006 Nov 10;281(45):34677-86 [16973615] Cancer Res. 2008 May 1;68(9):3193-203 [18451145] Mol Cancer Ther. 2008 Jul;7(7):1985-92 [18645008] Nature. 2006 Jul 6;442(7098):96-9 [16728974] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.febslet.2008.10.024 ER - TY - JOUR T1 - Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs. AN - 69784388; 18956868 AB - Although O(2)-(2,4-dinitrophenyl) derivatives of diazeniumdiolate-based nitric oxide (NO) prodrugs bearing a free carboxylic acid group were activated by glutathione to release NO, these compounds were poor sources of intracellular NO and showed diminished antiproliferative activity against human leukemia HL-60 cells. The carboxylic acid esters of these prodrugs, however, were found to be superior sources of intracellular NO and potent inhibitors of HL-60 cell proliferation. JF - Organic letters AU - Chakrapani, Harinath AU - Maciag, Anna E AU - Citro, Michael L AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. chakrah@ncifcrf.gov Y1 - 2008/11/20/ PY - 2008 DA - 2008 Nov 20 SP - 5155 EP - 5158 VL - 10 IS - 22 KW - Azo Compounds KW - 0 KW - Prodrugs KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Rats KW - Cell Proliferation -- drug effects KW - Permeability KW - Animals KW - Intracellular Space -- metabolism KW - Humans KW - Cell Line, Tumor KW - Prodrugs -- chemistry KW - Azo Compounds -- chemistry KW - Prodrugs -- pharmacology KW - Nitric Oxide -- pharmacology KW - Nitric Oxide -- metabolism KW - Nitric Oxide -- chemistry KW - Prodrugs -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69784388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=Cell-permeable+esters+of+diazeniumdiolate-based+nitric+oxide+prodrugs.&rft.au=Chakrapani%2C+Harinath%3BMaciag%2C+Anna+E%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2008-11-20&rft.volume=10&rft.issue=22&rft.spage=5155&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=1523-7052&rft_id=info:doi/10.1021%2Fol8020989 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-15 N1 - Date created - 2008-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/ol8020989 ER - TY - JOUR T1 - A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein AN - 19503087; 8713532 AB - Allyl acetate (AAC), allyl alcohol (AAL), and acrolein (ACR) are used in the manufacture of detergents, plastics, pharmaceuticals, and chemicals and as agricultural agents. A metabolic relationship exists between these chemicals in which allyl acetate is metabolized to allyl alcohol and subsequently to the highly reactive, a,b-unsaturated aldehyde, acrolein. Due to the weaker reactivity of the protoxicants, allyl acetate and allyl alcohol, relative to acrolien we hypothesized the protoxicants would attain greater systemic exposure and therefore deliver higher doses of acrolein to the internal organs. By extension, the higher systemic exposure to acrolein we hypothesized should lead to more internal organ toxicity in the allyl acetate and allyl alcohol treated animals relative to those treated with acrolein. To address our hypothesis we compared the range of toxicities produced by all three chemicals in male and female Fischer 344/N rats and B6C3F1 mice exposed 5 days a week for 3 months by gavage in 0.5% methylcellulose. Rats (10/group) were dosed with 0-100mg/kg allyl acetate, 0-25mg/kg allyl alcohol, or 0-10mg/kg acrolein. Mice (10 /group) were dosed with 0-125mg/kg allyl acetate, 0-50mg/kg allyl alcohol, or 0-20mg/kg acrolein. The highest dose of allyl acetate and acrolein decreased survival in both mice and rats. The primary target organ for the toxicity of all three chemicals in both species and sexes was the forestomach; squamous epithelial hyperplasia was observed following exposure to each chemical. In both species the highest allyl acetate dose group exhibited forestomach epithelium necrosis and hemorrhage and the highest dose of acrolein led to glandular stomach hemorrhage. Liver histopathology was the most apparent with allyl acetate, was also observed with allyl alcohol, but was not observed with acrolein. All chemicals had effects on the hematopoietic system with allyl acetate having the most pronounced effect. When dosed at quantities limited by toxicity, allyl acetate and allyl alcohol produce higher levels of urinary mercapturic acids than the minimally toxic dose of acrolein. This observation is likely due to biotransformation of allyl acetate and ally alcohol to acrolein that occurs after absorption and suggests that these chemicals are protoxicants that increase systemic exposure of acrolein. Increased systemic exposure to acrolein is likely responsible for the differences in hepatic toxicological profile observed with these chemicals. JF - Toxicology AU - Auerbach, S S AU - Mahler, J AU - Travlos, G S AU - Irwin, R D AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States, auerbachs@niehs.nih.gov Y1 - 2008/11/20/ PY - 2008 DA - 2008 Nov 20 SP - 79 EP - 88 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 253 IS - 1-3 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Detergents KW - biotransformation KW - Survival KW - Toxicity KW - Hemorrhage KW - Acetic acid KW - methylcellulose KW - Hyperplasia KW - Necrosis KW - Acrolein KW - Acids KW - allyl alcohol KW - alcohols KW - Liver KW - Pharmaceuticals KW - Hemopoiesis KW - Epithelium KW - Plastics KW - Aldehydes KW - Stomach KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19503087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=A+comparative+90-day+toxicity+study+of+allyl+acetate%2C+allyl+alcohol+and+acrolein&rft.au=Auerbach%2C+S+S%3BMahler%2C+J%3BTravlos%2C+G+S%3BIrwin%2C+R+D&rft.aulast=Auerbach&rft.aufirst=S&rft.date=2008-11-20&rft.volume=253&rft.issue=1-3&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2008.08.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Detergents; biotransformation; Survival; Toxicity; Hemorrhage; Acetic acid; methylcellulose; Necrosis; Hyperplasia; Acrolein; Acids; allyl alcohol; Liver; alcohols; Hemopoiesis; Pharmaceuticals; Epithelium; Plastics; Aldehydes; Stomach DO - http://dx.doi.org/10.1016/j.tox.2008.08.014 ER - TY - JOUR T1 - Recent Trends in Breast Cancer Among Younger Women in the United States AN - 19754752; 8818195 AB - Increases in the incidence of postmenopausal breast cancers have been linked to screening and menopausal hormone use, but younger women have received less attention. Thus, we analyzed trends in breast cancer incidence (N = 387 231) using the National Cancer Institute's Surveillance, Epidemiology, and End Results Program 13-Registry database (1992-2004). Whites had higher incidence rates than blacks after age 40 years, but the reverse was true among younger women (black-white crossover). Among younger women, the rate per 100 000 woman-years was 16.8 for black vs 15.1 for white women; the highest black-white incidence rate ratio (IRR) was seen among women younger than 30 years (IRR = 1.52, 95% confidence interval = 1.34 to 1.73). This risk pattern was not observed in other ethnic groups. The black-white crossover among younger women was largely restricted to breast cancers with favorable tumor characteristics. The annual percentage change in the incidence of invasive breast cancers decreased modestly among older women but increased among younger ([Lt]40 years) white women. Continued surveillance of trends is needed, particularly for molecular subtypes that preferentially occur among young women. JF - Journal of the National Cancer Institute AU - Brinton, Louise A AU - Sherman, Mark E AU - Carreon, JDaniel AU - Anderson, William F AD - Affiliations of authors: Hormonal and Reproductive Epidemiology Branch (LAB, MES, JDC) and Biostatistics Branch (WFA), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, brinton@nih.gov Y1 - 2008/11/19/ PY - 2008 DA - 2008 Nov 19 SP - 1643 EP - 1648 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 22 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Age KW - post-menopause KW - tumors KW - Hormones KW - USA KW - Breast cancer KW - Females KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19754752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Recent+Trends+in+Breast+Cancer+Among+Younger+Women+in+the+United+States&rft.au=Brinton%2C+Louise+A%3BSherman%2C+Mark+E%3BCarreon%2C+JDaniel%3BAnderson%2C+William+F&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2008-11-19&rft.volume=100&rft.issue=22&rft.spage=1643&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn344 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Breast cancer; post-menopause; tumors; Females; Ethnic groups; Age; Hormones DO - http://dx.doi.org/10.1093/jnci/djn344 ER - TY - JOUR T1 - Calcium Plus Vitamin D Supplementation and the Risk of Breast Cancer AN - 19656507; 8818190 AB - Background Although some observational studies have associated higher calcium intake and especially higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk, no randomized trial has evaluated these relationships.Methods Postmenopausal women (N = 36282) who were enrolled in a Women's Health Initiative clinical trial were randomly assigned to 1000 mg of elemental calcium with 400 IU of vitamin D3 daily or placebo for a mean of 7.0 years to determine the effects of supplement use on incidence of hip fracture. Mammograms and breast exams were serially conducted. Invasive breast cancer was a secondary outcome. Baseline serum 25-hydroxyvitamin D levels were assessed in a nested case-control study of 1067 case patients and 1067 control subjects. A Cox proportional hazards model was used to estimate the risk of breast cancer associated with random assignment to calcium with vitamin D3. Associations between 25-hydroxyvitamin D serum levels and total vitamin D intake, body mass index (BMI), recreational physical activity, and breast cancer risks were evaluated using logistic regression models. Statistical tests were two-sided.Results Invasive breast cancer incidence was similar in the two groups (528 supplement vs 546 placebo; hazard ratio = 0.96; 95% confidence interval = 0.85 to 1.09). In the nested case-control study, no effect of supplement group assignment on breast cancer risk was seen. Baseline 25-hydroxyvitamin D levels were modestly correlated with total vitamin D intake (diet and supplements) (r = 0.19, P [Lt] .001) and were higher among women with lower BMI and higher recreational physical activity (both P [Lt] .001). Baseline 25-hydroxyvitamin D levels were not associated with breast cancer risk in analyses that were adjusted for BMI and physical activity (Ptrend = .20).Conclusions Calcium and vitamin D supplementation did not reduce invasive breast cancer incidence in postmenopausal women. In addition, 25-hydroxyvitamin D levels were not associated with subsequent breast cancer risk. These findings do not support a relationship between total vitamin D intake and 25-hydroxyvitamin D levels with breast cancer risk. JF - Journal of the National Cancer Institute AU - Chlebowski, Rowan T AU - Johnson, Karen C AU - Kooperberg, Charles AU - Pettinger, Mary AU - Wactawski-Wende, Jean AU - Rohan, Tom AU - Rossouw, Jacques AU - Lane, Dorothy AU - O'Sullivan, Mary Jo AU - Yasmeen, Shagufta AU - Hiatt, Robert A AU - Shikany, James M AU - Vitolins, Mara AU - Khandekar, Janu AU - Hubbell, FAllan AD - Affiliations of authors: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA (RTC); Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN (KCJ); Fred Hutchinson Cancer Research Center, Seattle, WA (CK, MP); Department of Social and Preventive Medicine, State University of New York, Buffalo, NY (JW-W); Albert Einstein College of Medicine, Bronx, NY (TR); National Heart, Lung, and Blood Institute, Bethesda, MD (JR); Department of Preventive Medicine, State University of New York, Stony Brook, NY (DL); Department of Obstetrics-Gynecology, University of Miami, Miami, FL (MJO); Department of Medicine, University of California at Davis, Sacramento, CA (SY); Department of Epidemiology & Biostatics, University of California at San Francisco, San Francisco, CA (RAH); Department of Preventive Medicine, University of Alabama, Birmingham, AL (JMS); Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC (MV, rchlebowski@gmail.com Y1 - 2008/11/19/ PY - 2008 DA - 2008 Nov 19 SP - 1581 EP - 1591 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 100 IS - 22 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Invasiveness KW - Calcium KW - Physical activity KW - Statistical analysis KW - 25-Hydroxyvitamin D KW - clinical trials KW - Clinical trials KW - vitamins KW - Post-menopause KW - body mass KW - Risk factors KW - Regression analysis KW - physical activity KW - Diets KW - post-menopause KW - Fractures KW - Cancer KW - Serum levels KW - hip fracture KW - Vitamin D KW - Vitamin D3 KW - Recreation areas KW - Dietary supplements KW - Breast cancer KW - Body mass index KW - Hip KW - R2 23060:Medical and environmental health KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19656507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Calcium+Plus+Vitamin+D+Supplementation+and+the+Risk+of+Breast+Cancer&rft.au=Chlebowski%2C+Rowan+T%3BJohnson%2C+Karen+C%3BKooperberg%2C+Charles%3BPettinger%2C+Mary%3BWactawski-Wende%2C+Jean%3BRohan%2C+Tom%3BRossouw%2C+Jacques%3BLane%2C+Dorothy%3BO%27Sullivan%2C+Mary+Jo%3BYasmeen%2C+Shagufta%3BHiatt%2C+Robert+A%3BShikany%2C+James+M%3BVitolins%2C+Mara%3BKhandekar%2C+Janu%3BHubbell%2C+FAllan&rft.aulast=Chlebowski&rft.aufirst=Rowan&rft.date=2008-11-19&rft.volume=100&rft.issue=22&rft.spage=1581&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjn360 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Breast cancer; Cancer; vitamins; Calcium; physical activity; Recreation areas; post-menopause; clinical trials; hip fracture; Diets; body mass; 25-Hydroxyvitamin D; Vitamin D; Dietary supplements; Invasiveness; Physical activity; Clinical trials; Vitamin D3; Regression analysis; Post-menopause; Body mass index; Hip; Statistical analysis; Fractures; Risk factors; Serum levels DO - http://dx.doi.org/10.1093/jnci/djn360 ER - TY - CPAPER T1 - Diet, physical activity, and weight control services by US primary care physicians: influence on physicians' health behaviors and health status T2 - 2008 International Conference on Doctors Health AN - 41689820; 4992085 JF - 2008 International Conference on Doctors Health AU - Smith, Ashley AU - Klabunde, Carrie AU - Huang, Terry AU - Ballard-Barbash, Rachel Y1 - 2008/11/17/ PY - 2008 DA - 2008 Nov 17 KW - Physical activity KW - Diets KW - Obesity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41689820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2008+International+Conference+on+Doctors+Health&rft.atitle=Diet%2C+physical+activity%2C+and+weight+control+services+by+US+primary+care+physicians%3A+influence+on+physicians%27+health+behaviors+and+health+status&rft.au=Smith%2C+Ashley%3BKlabunde%2C+Carrie%3BHuang%2C+Terry%3BBallard-Barbash%2C+Rachel&rft.aulast=Smith&rft.aufirst=Ashley&rft.date=2008-11-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2008+International+Conference+on+Doctors+Health&rft.issn=&rft_id=info:doi/ L2 - http://web2.bma.org.uk/dhc.nsf/AttachmentsByTitle/PDFd4dfinalabstract/ $FILE/final+abstract+brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A guide for the perplexed: A rabbi's alternative to Bacon, and the challenges of post-genomic research T2 - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AN - 41952518; 5127766 JF - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AU - Ribeiro, Jose Y1 - 2008/11/16/ PY - 2008 DA - 2008 Nov 16 KW - Bacon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41952518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.atitle=A+guide+for+the+perplexed%3A+A+rabbi%27s+alternative+to+Bacon%2C+and+the+challenges+of+post-genomic+research&rft.au=Ribeiro%2C+Jose&rft.aulast=Ribeiro&rft.aufirst=Jose&rft.date=2008-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2008/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Midgut transcript expression profiling in Leishmania-infected sand flies T2 - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AN - 41920368; 5127740 JF - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AU - Jochim, Ryan Y1 - 2008/11/16/ PY - 2008 DA - 2008 Nov 16 KW - Sand KW - Transcription KW - Midgut KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41920368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.atitle=Midgut+transcript+expression+profiling+in+Leishmania-infected+sand+flies&rft.au=Jochim%2C+Ryan&rft.aulast=Jochim&rft.aufirst=Ryan&rft.date=2008-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2008/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using mathematical modeling and genetic algorithms to optimize the control of the Chagas disease vector, Triatoma infestans, in Arequipa, Peru T2 - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AN - 41918088; 5127720 JF - 56th Annual Meeting of the Entomological Society of America (ESA 2008) AU - Levy, Michael Y1 - 2008/11/16/ PY - 2008 DA - 2008 Nov 16 KW - Peru KW - Algorithms KW - Mathematical models KW - Chagas' disease KW - Disease transmission KW - Hosts KW - Disease control KW - Triatoma infestans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41918088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.atitle=Using+mathematical+modeling+and+genetic+algorithms+to+optimize+the+control+of+the+Chagas+disease+vector%2C+Triatoma+infestans%2C+in+Arequipa%2C+Peru&rft.au=Levy%2C+Michael&rft.aulast=Levy&rft.aufirst=Michael&rft.date=2008-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+Entomological+Society+of+America+%28ESA+2008%29&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2008/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-17 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs AN - 883034984; 15305928 AB - Nitric oxide (NO) prodrugs such as O super(2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate (JS-K) are a growing class of promising NO-based therapeutics. Nitric oxide release from the anti-cancer lead compound, JS-K, is proposed to occur through a nucleophilic aromatic substitution by glutathione (GSH) catalyzed by glutathione S-transferase (GST) to form a diazeniumdiolate anion that spontaneously releases NO. In this study, a number of structural analogues of JS-K were synthesized and their chemical and biological properties were compared with those of JS-K. The homopiperazine analogue of JS-K showed anti-cancer activity that is comparable with that of JS-K but with a diminished reactivity towards both GSH and GSH/GST; both the aforementioned compounds displayed no cytotoxic activity towards normal renal epithelial cell line at concentrations where they significantly diminished the proliferation of a panel of renal cancer cell lines. These properties may prove advantageous in the further development of this class of nitric oxide prodrugs as cancer therapeutic agents.) JF - Bioorganic and Medicinal Chemistry AU - Chakrapani, Harinath AU - Kalathur, Ravi C AU - Maciag, Anna E AU - Citro, Michael L AU - Ji, Xinhua AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA Y1 - 2008/11/15/ PY - 2008 DA - 2008 Nov 15 SP - 9764 EP - 9771 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 16 IS - 22 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Epithelial cells KW - Tumor cell lines KW - Cytotoxicity KW - Anions KW - prodrugs KW - Kidney KW - Nitric oxide KW - Glutathione transferase KW - Cancer KW - Aromatics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883034984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Synthesis%2C+mechanistic+studies%2C+and+anti-proliferative+activity+of+glutathione%2Fglutathione+S-transferase-activated+nitric+oxide+prodrugs&rft.au=Chakrapani%2C+Harinath%3BKalathur%2C+Ravi+C%3BMaciag%2C+Anna+E%3BCitro%2C+Michael+L%3BJi%2C+Xinhua%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2008-11-15&rft.volume=16&rft.issue=22&rft.spage=9764&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2008.09.063 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Cytotoxicity; Tumor cell lines; Anions; prodrugs; Kidney; Nitric oxide; Glutathione transferase; Aromatics; Cancer DO - http://dx.doi.org/10.1016/j.bmc.2008.09.063 ER - TY - JOUR T1 - The use of genetic markers to identify lung cancer in fine needle aspiration samples. AN - 69798844; 19010865 AB - We seek to establish a genetic test to identify lung cancer using cells obtained through computed tomography-guided fine needle aspiration (FNA). We selected regions of frequent copy number gains in chromosomes 1q32, 3q26, 5p15, and 8q24 in non-small cell lung cancer and tested their ability to determine the neoplastic state of cells obtained by FNA using fluorescent in situ hybridization. Two sets of samples were included. The pilot set included six paraffin-embedded, noncancerous lung tissues and 33 formalin-fixed FNA specimens. These 39 samples were used to establish the optimal fixation and single scoring criteria for the samples. The test set included 40 FNA samples. The results of the genetic test were compared with the cytology, pathology, and clinical follow-up for each case to assess the sensitivity and specificity of the genetic test. Nontumor lung tissues had or = 5 signals per nucleus in five or more cells for at least one marker. Among the 40 testing cases, 36 of 40 (90%) FNA samples were analyzable. Genetic analysis identified 15 cases as tumor and 21 cases as nontumor. Clinical and pathologic diagnoses confirmed the genetic test in 15 of 16 lung cancer cases regardless of tumor subtype, stage, or size and in 20 of 20 cases diagnosed as benign lung diseases. A set of only four genetic markers can distinguish the neoplastic state of lung lesion using small samples obtained through computed tomography-guided FNA. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Gill, Rajbir K AU - Vazquez, Madeline F AU - Kramer, Arin AU - Hames, Megan AU - Zhang, Lijuan AU - Heselmeyer-Haddad, Kerstin AU - Ried, Thomas AU - Shilo, Konstantin AU - Henschke, Claudia AU - Yankelevitz, David AU - Jen, Jin AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2008/11/15/ PY - 2008 DA - 2008 Nov 15 SP - 7481 EP - 7487 VL - 14 IS - 22 SN - 1078-0432, 1078-0432 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Surgery, Computer-Assisted KW - Humans KW - Tomography, X-Ray Computed KW - In Situ Hybridization, Fluorescence KW - Aged KW - Microscopy, Fluorescence KW - Aged, 80 and over KW - Adult KW - Chromosome Aberrations KW - Middle Aged KW - Female KW - Male KW - Biomarkers, Tumor -- genetics KW - Lung Neoplasms -- diagnosis KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- genetics KW - Carcinoma, Non-Small-Cell Lung -- diagnosis KW - Biopsy, Needle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69798844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=The+use+of+genetic+markers+to+identify+lung+cancer+in+fine+needle+aspiration+samples.&rft.au=Gill%2C+Rajbir+K%3BVazquez%2C+Madeline+F%3BKramer%2C+Arin%3BHames%2C+Megan%3BZhang%2C+Lijuan%3BHeselmeyer-Haddad%2C+Kerstin%3BRied%2C+Thomas%3BShilo%2C+Konstantin%3BHenschke%2C+Claudia%3BYankelevitz%2C+David%3BJen%2C+Jin&rft.aulast=Gill&rft.aufirst=Rajbir&rft.date=2008-11-15&rft.volume=14&rft.issue=22&rft.spage=7481&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-07-5242 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-05 N1 - Date created - 2008-11-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Vasc Interv Radiol. 2004 Feb;15(2 Pt 1):161-4 [14963182] Ann Intern Med. 2004 May 4;140(9):740-53 [15126259] Chest. 2004 Sep;126(3):761-5 [15364754] Lab Invest. 1989 Aug;61(2):235-42 [2755080] Cancer Res. 1991 Jan 15;51(2):644-51 [1985781] Diagn Cytopathol. 1990;6(5):317-22 [2292218] Cytometry. 1991;12(7):614-21 [1723676] Am J Pathol. 1993 Jan;142(1):307-17 [7678720] Cancer Res. 1994 Apr 1;54(7):1801-6 [8137295] Int J Cancer. 1994 Jun 15;57(6):781-5 [8206672] Cancer Res. 1995 Nov 1;55(21):5030-7 [7585547] Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):479-84 [8552665] Genes Chromosomes Cancer. 1996 Jun;16(2):106-12 [8818657] Chest. 1997 Jun;111(6):1691-6 [9187195] Chest. 1997 Jun;111(6):1710-7 [9187198] Cancer Res. 1997 Jun 15;57(12):2331-5 [9192802] Clin Imaging. 1998 Jan-Feb;22(1):7-10 [9421648] Genes Chromosomes Cancer. 1998 May;22(1):79-82 [9591638] Lancet. 1999 Jul 10;354(9173):99-105 [10408484] Clin Cancer Res. 2004 Dec 1;10(23):7820-6 [15585613] Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30 [15983384] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] Cancer Res. 2000 Apr 1;60(7):1968-73 [10766187] Am J Pathol. 2000 Aug;157(2):689 [10934171] Cancer Genet Cytogenet. 2001 Mar;125(2):87-99 [11369051] Genes Chromosomes Cancer. 2001 Jul;31(3):282-7 [11391799] Cancer. 2001 Dec 25;93(6):364-75 [11748576] Ann Thorac Surg. 2001 Dec;72(6):1861-7 [11789761] Am J Respir Crit Care Med. 2002 Feb 15;165(4):508-13 [11850344] Oncogene. 2002 Oct 7;21(45):6877-83 [12362270] Cancer. 2002 Oct 25;96(5):306-15 [12378599] Radiology. 2003 Mar;226(3):756-61 [12601181] J Mol Diagn. 2003 May;5(2):103-12 [12707375] Nat Genet. 2003 Aug;34(4):369-76 [12923544] Am J Pathol. 2003 Oct;163(4):1405-16 [14507648] Chest. 2005 Aug;128(2):906-11 [16100185] Radiology. 2006 May;239(2):586-90 [16641357] Br J Cancer. 2006 Aug 7;95(3):331-8 [16847471] N Engl J Med. 2006 Oct 26;355(17):1763-71 [17065637] Cancer. 2007 Aug 25;111(4):252-8 [17614298] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-07-5242 ER - TY - JOUR T1 - Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy. AN - 69791093; 19010904 AB - Interleukin-13 (IL-13) receptor alpha2 (IL-13Ralpha2), a high-affinity IL-13 binding subunit and a tumor antigen, is amplified in a variety of human tumor cell lines and tumors in vivo. By cDNA microarray, we have shown that gene transfer of human and rat adrenomedullin (AM) up-regulates IL-13Ralpha2 in a human prostate tumor cell line. Here, we show that IL-13Ralpha2 mRNA and protein are also up-regulated in PC-3 prostate tumor cells by recombinant AM (rAM) and human synthetic AM peptide in a dose-dependent manner in vitro and in vivo in mouse prostate tumor model. The 8- to 10-fold up-regulation of IL-13Ralpha2 by rAM or AM peptide in prostate tumor cells in vitro and in vivo increased their sensitivity to IL-13PE cytotoxin consisting of IL-13 and a truncated form of Pseudomonas exotoxin. Immunodeficient mice with established prostate tumors transfected with AM or treated with AM peptide showed reduction in tumor size by intratumoral administration of IL-13PE in a dose-dependent manner. At the highest dose (three 100 mug/kg/d every alternate day), >70% reduction of tumor size was observed compared with controls (P or = 67 years) with hematopoietic malignancies and 122,531 population-based controls, frequency-matched by gender, age, and year (1993--2002). Logistic regression was used to compare the prevalence of HCV, HBV, and alcoholic hepatitis in cases and controls, adjusted for matching factors, race, duration of Medicare coverage, and number of physician claims. HCV, HBV, and alcoholic hepatitis were reported in 195 (0.3%), 111 (0.2%), and 404 (0.7%) cases and 264 (0.2%), 242 (0.2%), and 798 (0.7%) controls, respectively. HCV was associated with increased risk of diffuse large B-cell lymphoma [odds ratio (OR) 1.52, 95% confidence interval (95% CI) 1.05-2.18], Burkitt lymphoma (OR 5.21, 95% CI 1.62-16.8), follicular lymphoma (OR 1.88, 95% CI 1.17-3.02), marginal zone lymphoma (OR 2.20, 95% CI 1.22-3.95), and acute myeloid leukemia (OR 1.54, 95% CI 1.00-2.37). In contrast, HBV was unrelated to any hematopoietic malignancies. Alcoholic hepatitis was associated with decreased risk of non-Hodgkin lymphoma overall, but increased risk of Burkitt lymphoma. In summary, HCV, but not other causes of hepatitis, was associated with the elevated risk of non-Hodgkin lymphoma and acute myeloid leukemia. HCV may induce lymphoproliferative malignancies through chronic immune stimulation. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Anderson, Lesley A AU - Pfeiffer, Ruth AU - Warren, Joan L AU - Landgren, Ola AU - Gadalla, Shahinaz AU - Berndt, Sonja I AU - Ricker, Winnie AU - Parsons, Ruth AU - Wheeler, William AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7076 Rockville, MD 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 3069 EP - 3075 VL - 17 IS - 11 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Logistic Models KW - Aged, 80 and over KW - Humans KW - SEER Program KW - Case-Control Studies KW - Aged KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Hepatitis, Alcoholic -- complications KW - Hepatitis B -- complications KW - Hematologic Neoplasms -- etiology KW - Hepatitis C -- complications KW - Hepatitis, Alcoholic -- epidemiology KW - Hematologic Neoplasms -- virology KW - Hepatitis C -- epidemiology KW - Hematologic Neoplasms -- epidemiology KW - Hepatitis B -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69757629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Hematopoietic+malignancies+associated+with+viral+and+alcoholic+hepatitis.&rft.au=Anderson%2C+Lesley+A%3BPfeiffer%2C+Ruth%3BWarren%2C+Joan+L%3BLandgren%2C+Ola%3BGadalla%2C+Shahinaz%3BBerndt%2C+Sonja+I%3BRicker%2C+Winnie%3BParsons%2C+Ruth%3BWheeler%2C+William%3BEngels%2C+Eric+A&rft.aulast=Anderson&rft.aufirst=Lesley&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=3069&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/10.1158%2F1055-9965.EPI-08-0408 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-10 N1 - Date created - 2008-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Haematol. 1999 Nov;107(2):353-6 [10583224] Blood. 2008 Apr 1;111(7):3388-94 [18239085] J Gastroenterol Hepatol. 2001 Feb;16(2):215-9 [11207904] Eur J Clin Invest. 2001 Jul;31(7):628-38 [11454019] Acta Haematol. 2001;105(4):237-40 [11528098] Liver. 2001 Oct;21(5):335-41 [11589770] Jpn J Cancer Res. 2002 May;93(5):471-7 [12036441] Alcohol. 2002 May;27(1):17-21 [12062632] N Engl J Med. 2002 Jul 11;347(2):89-94 [12110736] Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S50-3 [12142963] Med Care. 2002 Aug;40(8 Suppl):IV-3-18 [12187163] Hematol J. 2003;4(5):303-9 [14502253] J Med Microbiol. 2004 Jan;53(Pt 1):21-9 [14663101] Haematologica. 2004 Jan;89(1):70-6 [14754608] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):425-30 [15006919] Med Oncol. 2004;21(1):67-72 [15034216] Int J Cancer. 2004 Aug 10;111(1):81-5 [15185347] Cancer Sci. 2004 Sep;95(9):745-52 [15471561] Gastroenterology. 1991 Jan;100(1):182-8 [1983820] Haematologica. 1996 Mar-Apr;81(2):162-4 [8641648] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):227-30 [8833624] Hum Pathol. 1997 Jan;28(1):101-4 [9013840] Arch Virol. 1997;142(3):545-55 [9349300] Blood. 1998 Nov 1;92(9):3328-37 [9787170] Science. 1998 Oct 30;282(5390):938-41 [9794763] Am J Public Health. 1999 Jan;89(1):14-8 [9987458] Leuk Lymphoma. 1999 Jun;34(1-2):45-52 [10350331] Br J Cancer. 1999 Jul;80(9):1476-82 [10424754] Eur J Haematol. 2005 Feb;74(2):158-65 [15654908] Hepatology. 2005 Mar;41(3):652-9 [15723449] Expert Opin Drug Saf. 2005 May;4(3):599-608 [15934864] Clin Gastroenterol Hepatol. 2008 Apr;6(4):451-8 [18387498] Lancet Oncol. 2005 Jul;6(7):469-76 [15992695] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18544-9 [16339892] Haematologica. 2006 Apr;91(4):554-7 [16585021] J Hepatol. 2006 Aug;45(2):197-203 [16684579] AIDS. 2006 Aug 1;20(12):1645-54 [16868446] Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2078-85 [17119031] Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):401-4 [17337646] Cancer. 2007 Apr 1;109(7):1360-4 [17326056] JAMA. 2007 May 9;297(18):2010-7 [17488966] Blood. 2007 Jul 15;110(2):695-708 [17389762] Hepatology. 2007 Jul;46(1):107-12 [17526021] Eur J Haematol. 2007 Aug;79(2):132-7 [17635237] Br J Haematol. 2007 Dec;139(5):791-8 [17941950] J Hepatol. 1999;31 Suppl 1:88-91 [10622567] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1055-9965.EPI-08-0408 ER - TY - JOUR T1 - Endogenous retroviruses--aiding and abetting genomic plasticity. AN - 69755136; 18818876 JF - Cellular and molecular life sciences : CMLS AU - Eiden, M V AD - National Institutes of Health, Bethesda, Maryland 20892, USA. eidenm@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 3325 EP - 3328 VL - 65 IS - 21 KW - Index Medicus KW - Animals KW - Humans KW - Cell Transformation, Viral -- genetics KW - Proviruses -- genetics KW - Germ Cells -- virology KW - Vertebrates -- virology KW - Virus Integration KW - Mutagenesis, Insertional KW - Evolution, Molecular KW - Host-Pathogen Interactions -- genetics KW - Endogenous Retroviruses -- physiology KW - Host-Pathogen Interactions -- physiology KW - Endogenous Retroviruses -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69755136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.atitle=Endogenous+retroviruses--aiding+and+abetting+genomic+plasticity.&rft.au=Eiden%2C+M+V&rft.aulast=Eiden&rft.aufirst=M&rft.date=2008-11-01&rft.volume=65&rft.issue=21&rft.spage=3325&rft.isbn=&rft.btitle=&rft.title=Cellular+and+molecular+life+sciences+%3A+CMLS&rft.issn=1420-9071&rft_id=info:doi/10.1007%2Fs00018-008-8493-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-19 N1 - Date created - 2008-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Feb 17;403(6771):785-9 [10693809] Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17506-11 [17959780] J Virol. 2000 May;74(9):4264-72 [10756041] J Biol Chem. 2001 Jan 19;276(3):1896-903 [11054415] J Gen Virol. 1971 Feb;10(2):195-8 [4324256] Nat New Biol. 1972 Feb 9;235(58):170-1 [4501200] Genes Dev. 1992 Aug;6(8):1457-65 [1379564] Nucleic Acids Res. 1993 Jan 11;21(1):135-43 [8382789] J Virol. 2006 Mar;80(6):3104-7 [16501122] J Virol. 2006 Jun;80(11):5651-4 [16699047] Nature. 2006 Jul 6;442(7098):79-81 [16823453] Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14390-5 [16980413] Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6261-5 [17384150] Cell Physiol Biochem. 2007;20(5):517-26 [17762178] J Virol. 2007 Oct;81(20):11441-51 [17699582] J Virol. 2000 Apr;74(7):3321-9 [10708449] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00018-008-8493-4 ER - TY - JOUR T1 - Genome wide transcriptional profiling in breast cancer cells reveals distinct changes in hormone receptor target genes and chromatin modifying enzymes after proteasome inhibition. AN - 69748824; 18381591 AB - Steroid hormone receptors, like glucocorticoid (GR) and estrogen receptors (ER), are master regulators of genes that control many biological processes implicated in health and disease. Gene expression is dependent on receptor levels which are tightly regulated by the ubiquitin-proteasome system. Previous studies have shown that proteasome inhibition increases GR, but decreases ER-mediated gene expression. At the gene expression level this divergent role of the proteasome in receptor-dependent transcriptional regulation is not well understood. We have used a genomic approach to examine the impact of proteasome activity on GR- and ER-mediated gene expression in MCF-7 breast cancer cells treated with dexamethasone (DEX) or 17beta-estradiol (E2), the proteasome inhibitor MG132 (MG) or MG132 and either hormone (MD or ME2) for 24 h. Transcript profiling reveals that inhibiting proteasome activity modulates gene expression by GR and ER in a similar manner in that several GR and ER target genes are upregulated and downregulated after proteasome inhibition. In addition, proteasome inhibition modulates receptor-dependent genes involved in the etiology of a number of human pathological states, including multiple myeloma, leukemia, breast/prostate cancer, HIV/AIDS, and neurodegenerative disorders. Importantly, our analysis reveals that a number of transcripts encoding histone and DNA modifying enzymes, prominently histone/DNA methyltransferases and demethylases, are altered after proteasome inhibition. As proteasome inhibitors are currently in clinical trials as therapy for multiple myeloma, HIV/AIDS and leukemia, the possibility that some of the target molecules are hormone regulated and chromatin modifying enzymes is intriguing in this era of epigenetic therapy. JF - Molecular carcinogenesis AU - Kinyamu, H Karimi AU - Collins, Jennifer B AU - Grissom, Sherry F AU - Hebbar, Pratibha B AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 845 EP - 885 VL - 47 IS - 11 KW - Chromatin KW - 0 KW - Glucocorticoids KW - Proteasome Inhibitors KW - Receptors, Estrogen KW - DNA KW - 9007-49-2 KW - RNA Polymerase II KW - EC 2.7.7.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - RNA Polymerase II -- metabolism KW - Glucocorticoids -- metabolism KW - Gene Expression Profiling KW - Proteasome Endopeptidase Complex -- metabolism KW - Humans KW - DNA -- metabolism KW - DNA -- genetics KW - Cell Line, Tumor KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Gene Expression Regulation, Neoplastic -- genetics KW - Breast Neoplasms -- genetics KW - Receptors, Estrogen -- antagonists & inhibitors KW - Chromatin -- metabolism KW - Transcription, Genetic -- drug effects KW - Genome, Human -- genetics KW - Transcription, Genetic -- genetics KW - Breast Neoplasms -- metabolism KW - Receptors, Estrogen -- metabolism KW - Chromatin -- genetics KW - Breast Neoplasms -- pathology KW - Chromatin -- drug effects KW - Breast Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69748824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Genome+wide+transcriptional+profiling+in+breast+cancer+cells+reveals+distinct+changes+in+hormone+receptor+target+genes+and+chromatin+modifying+enzymes+after+proteasome+inhibition.&rft.au=Kinyamu%2C+H+Karimi%3BCollins%2C+Jennifer+B%3BGrissom%2C+Sherry+F%3BHebbar%2C+Pratibha+B%3BArcher%2C+Trevor+K&rft.aulast=Kinyamu&rft.aufirst=H&rft.date=2008-11-01&rft.volume=47&rft.issue=11&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.20440 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-14 N1 - Date created - 2008-11-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Future Oncol. 2005 Apr;1(2):161-71 [16555986] Endocr J. 2006 Apr;53(2):157-72 [16618973] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Mol Cell Biol. 2006 Jul;26(13):5131-45 [16782897] Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12347-52 [16895980] EMBO J. 2006 Sep 20;25(18):4223-33 [16957778] Ann Intern Med. 2006 Nov 7;145(9):676-84 [17088581] Int J Oncol. 2006 Dec;29(6):1581-9 [17089000] Hematology Am Soc Hematol Educ Program. 2006;:1-12, 505-6 [17124032] Nature. 2006 Nov 30;444(7119):629-32 [17108971] Genome Res. 2006 Dec;16(12):1493-504 [17038565] Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19182-7 [17148615] Curr Pharm Biotechnol. 2006 Dec;7(6):441-8 [17168660] Mol Endocrinol. 2007 Jan;21(1):1-13 [16556737] J Biol Chem. 2007 Feb 9;282(6):4021-34 [17095510] J Biol Chem. 2007 Feb 9;282(6):3755-65 [17170114] Cell. 2007 Feb 9;128(3):505-18 [17289570] Cell. 2007 Feb 23;128(4):683-92 [17320506] J Biol Chem. 2007 Mar 16;282(11):8284-91 [17186943] Nat Rev Genet. 2007 Apr;8(4):286-98 [17339880] J Virol. 2007 Apr;81(8):4226-34 [17267505] Cancer. 2007 Jun 1;109(11):2285-90 [17469169] Mol Cell Biol. 2007 Jul;27(13):4891-904 [17438138] Med Hypotheses. 2007;69(4):816-20 [17379424] Curr Opin Genet Dev. 2006 Apr;16(2):197-202 [16503126] J Biol Chem. 2000 Jan 28;275(4):2654-60 [10644726] Mol Cell. 2000 Jun;5(6):939-48 [10911988] Nature. 2000 Aug 17;406(6797):747-52 [10963602] Genomics. 2001 Apr 1;73(1):86-97 [11352569] J Biol Chem. 2001 Sep 28;276(39):36467-73 [11479299] J Biol Chem. 2001 Nov 16;276(46):42714-21 [11555652] Nucleic Acids Res. 2002 Jan 1;30(1):207-10 [11752295] J Biol Chem. 2002 Feb 1;277(5):3537-43 [11724789] Physiol Rev. 2002 Apr;82(2):373-428 [11917093] Mol Cell Biol. 2002 Jun;22(12):4113-23 [12024025] Br J Haematol. 2002 Jun;117(3):626-8 [12028033] Mol Endocrinol. 2002 Jun;16(6):1204-14 [12040008] Mol Endocrinol. 2002 Jun;16(6):1215-29 [12040010] J Biol Chem. 2002 Sep 27;277(39):36570-6 [12119296] J Biol Chem. 2002 Oct 4;277(40):37254-9 [12118000] Histochem Cell Biol. 2002 Nov;118(5):399-408 [12432451] Breast Cancer Res. 2003;5(1):1-7 [12559038] Am J Pathol. 2003 Apr;162(4):1047-52 [12651597] Mol Cell. 2003 Mar;11(3):695-707 [12667452] Cancer Res. 2003 Apr 15;63(8):1731-6 [12702552] Mol Endocrinol. 2003 Jul;17(7):1315-31 [12663742] Mol Cell Biol. 2003 Aug;23(16):5867-81 [12897156] Endocrinology. 2003 Oct;144(10):4562-74 [12959972] FASEB J. 2003 Oct;17(13):1849-70 [14519664] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13845-50 [14617768] Nature. 2003 Dec 18;426(6968):895-9 [14685250] Stem Cells. 2004;22(1):51-64 [14688391] Cell. 2004 Jan 23;116(2):181-90 [14744430] Mol Endocrinol. 2004 Mar;18(3):493-9 [14673136] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):30-45 [15020043] Cell Mol Life Sci. 2004 Jul;61(13):1546-61 [15224180] Genome Biol. 2004;5(9):R66 [15345050] Br J Haematol. 2004 Oct;127(2):165-72 [15461622] Annu Rev Genet. 1985;19:209-52 [3909942] Nature. 1995 Mar 2;374(6517):91-4 [7870181] Cell. 1995 Dec 15;83(6):835-9 [8521507] Int J Cancer. 1996 May 29;66(5):692-7 [8647634] J Biol Chem. 1997 Apr 4;272(14):9573-80 [9083102] J Biol Chem. 1998 Jan 9;273(2):1175-83 [9422784] Clin Cancer Res. 1998 Dec;4(12):3045-50 [9865919] Annu Rev Med. 1999;50:57-74 [10073263] Clin Exp Metastasis. 1998 Jul;16(5):471-9 [10091942] Biochem Biophys Res Commun. 1999 Apr 21;257(3):738-45 [10208853] Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9212-7 [10430922] Mol Cell Biol. 1999 Nov;19(11):7327-35 [10523621] Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15603-8 [15501915] J Biol Chem. 2004 Nov 19;279(47):49120-30 [15347661] J Pathol. 2005 Jan;205(2):154-71 [15643670] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):749-54 [15640349] Crit Rev Eukaryot Gene Expr. 2004;14(4):235-54 [15663355] Endocr Rev. 2005 Apr;26(2):147-70 [15479858] J Mol Endocrinol. 2005 Apr;34(2):281-97 [15821097] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8603-8 [15941828] Mol Cell Biol. 2005 Nov;25(21):9198-208 [16227573] Nature. 2005 Nov 3;438(7064):113-6 [16267558] Cell. 2005 Nov 4;123(3):361-3 [16269325] Int J Oncol. 2005 Dec;27(6):1473-81 [16273201] Cell. 2006 Jan 27;124(2):381-92 [16439211] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.20440 ER - TY - JOUR T1 - Personal accounts: could Noah's life have been saved? Confronting dual diagnosis and a fragmented mental health system. AN - 69738573; 18971400 JF - Psychiatric services (Washington, D.C.) AU - Seidenberg, Gordon R AD - Division of AIDS and Health and Behavior Research, National Institute of Mental Health. gseidenberg@hotmail.com Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1254 EP - 1255 VL - 59 IS - 11 KW - Index Medicus KW - Young Adult KW - Humans KW - Substance-Related Disorders KW - Mental Health Services KW - Anecdotes as Topic KW - Male KW - Comorbidity KW - Quality of Health Care KW - Diagnosis, Dual (Psychiatry) KW - Suicide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69738573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatric+services+%28Washington%2C+D.C.%29&rft.atitle=Personal+accounts%3A+could+Noah%27s+life+have+been+saved%3F+Confronting+dual+diagnosis+and+a+fragmented+mental+health+system.&rft.au=Seidenberg%2C+Gordon+R&rft.aulast=Seidenberg&rft.aufirst=Gordon&rft.date=2008-11-01&rft.volume=59&rft.issue=11&rft.spage=1254&rft.isbn=&rft.btitle=&rft.title=Psychiatric+services+%28Washington%2C+D.C.%29&rft.issn=1557-9700&rft_id=info:doi/10.1176%2Fappi.ps.59.11.1254 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-27 N1 - Date created - 2008-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1176/appi.ps.59.11.1254 ER - TY - JOUR T1 - Routine diagnostic X-ray examinations and increased frequency of chromosome translocations among U.S. radiologic technologists. AN - 69732606; 18974125 AB - The U.S. population has nearly one radiographic examination per person per year, and concern about cancer risks associated with medical radiation has increased. Radiologic technologists were surveyed to determine whether their personal cumulative exposure to diagnostic X-rays was associated with increased frequencies of chromosome translocations, an established radiation biomarker and possible intermediary suggesting increased cancer risk. Within a large cohort of U.S. radiologic technologists, 150 provided a blood sample for whole chromosome painting and were interviewed about past X-ray examinations. The number and types of examinations reported were converted to a red bone marrow (RBM) dose score with units that approximated 1 mGy. The relationship between dose score and chromosome translocation frequency was assessed using Poisson regression. The estimated mean cumulative RBM radiation dose score was 49 (range, 0-303). After adjustment for age, translocation frequencies significantly increased with increasing RBM dose score with an estimate of 0.004 translocations per 100 cell equivalents per score unit (95% confidence interval, 0.002-0.007; P < 0.001). Removing extreme values or adjustment for gender, cigarette smoking, occupational radiation dose, allowing practice X-rays while training, work with radioisotopes, and radiotherapy for benign conditions did not affect the estimate. Cumulative radiation exposure from routine X-ray examinations was associated independently with increased chromosome damage, suggesting the possibility of elevated long-term health risks, including cancer. The slope estimate was consistent with expectation based on cytogenetic experience and atomic bomb survivor data. JF - Cancer research AU - Sigurdson, Alice J AU - Bhatti, Parveen AU - Preston, Dale L AU - Doody, Michele Morin AU - Kampa, Diane AU - Alexander, Bruce H AU - Petibone, Dayton AU - Yong, Lee C AU - Edwards, Alan A AU - Ron, Elaine AU - Tucker, James D AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Radiation Epidemiology Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. sigurdsa@mail.nih.gov Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 8825 EP - 8831 VL - 68 IS - 21 KW - Index Medicus KW - United States KW - Aged, 80 and over KW - Humans KW - Cohort Studies KW - In Situ Hybridization, Fluorescence KW - Aged KW - Dose-Response Relationship, Radiation KW - Male KW - Female KW - Occupational Exposure KW - Technology, Radiologic -- manpower KW - Translocation, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69732606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Routine+diagnostic+X-ray+examinations+and+increased+frequency+of+chromosome+translocations+among+U.S.+radiologic+technologists.&rft.au=Sigurdson%2C+Alice+J%3BBhatti%2C+Parveen%3BPreston%2C+Dale+L%3BDoody%2C+Michele+Morin%3BKampa%2C+Diane%3BAlexander%2C+Bruce+H%3BPetibone%2C+Dayton%3BYong%2C+Lee+C%3BEdwards%2C+Alan+A%3BRon%2C+Elaine%3BTucker%2C+James+D&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2008-11-01&rft.volume=68&rft.issue=21&rft.spage=8825&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-08-1691 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-08 N1 - Date created - 2008-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiat Res. 1998 Jun;149(6):602-13 [9611099] Radiat Res. 2008 Aug;170(2):149-55 [18666821] Radiat Res. 1999 Dec;152(6):655-64 [10581536] Radiat Res. 2001 Oct;156(4):337-46 [11554845] Int J Radiat Biol. 2001 Aug;77(8):901-8 [11571024] Radiat Prot Dosimetry. 2001;97(3):279-82; discussion 285 [11843345] Health Phys. 2002 Apr;82(4):455-66 [11906134] Health Phys. 2002 Dec;83(6):907-17 [12467299] Int J Cancer. 2003 Feb 10;103(4):556-62 [12478675] Health Phys. 2003 Feb;84(2):245-59 [12553655] Radiat Prot Dosimetry. 2003;103(1):35-40 [12596987] Am J Epidemiol. 2003 Apr 1;157(7):652-63 [12672685] Cancer. 2003 Jun 15;97(12):3080-9 [12784345] Health Phys. 2003 Jul;85(1):47-59 [12852471] Radiat Prot Dosimetry. 2003;106(2):131-5 [14653333] Lancet. 2004 Jan 31;363(9406):345-51 [15070562] Mutat Res. 1999 Jun 25;442(2):89-95 [10393277] Radiat Res. 2004 Sep;162(3):249-56 [15378837] Radiat Res. 2004 Oct;162(4):377-89 [15447045] Phys Med Biol. 1981 May;26(3):389-400 [7243876] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7474-6 [1881886] Int J Radiat Biol. 1992 Jul;62(1):53-63 [1353776] Radiology. 1993 Nov;189(2):377-80 [8210363] Health Phys. 1995 Feb;68(2):266-9 [7814260] Cytogenet Cell Genet. 1995;68(3-4):211-21 [7842739] Mutat Res. 1995 Oct;338(1-6):95-106 [7565886] Mutagenesis. 1995 Nov;10(6):487-95 [8596467] Environ Health Perspect. 1996 May;104 Suppl 3:489-92 [8781370] Radiat Res. 1997 Sep;148(3):216-26 [9291352] Environ Mol Mutagen. 1997;30(3):264-72 [9366904] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):229-48 [15657915] Radiat Prot Dosimetry. 2005;113(4):396-402 [15928034] Radiat Res. 2005 Nov;164(5):612-7 [16238438] Occup Environ Med. 2005 Dec;62(12):861-7 [16299095] Cancer. 2006 Jun 15;106(12):2707-15 [16639729] Radiat Res. 2006 Jul;166(1 Pt 2):174-92 [16808606] JAMA. 2006 Aug 9;296(6):638-40 [16896096] Mutat Res. 2006 Aug 30;600(1-2):37-45 [16814813] Radiat Res. 2007 Jun;167(6):727-34 [17523852] JAMA. 2007 Jul 18;298(3):317-23 [17635892] N Engl J Med. 2007 Nov 29;357(22):2277-84 [18046031] Mutat Res. 2008 Apr 30;652(2):112-21 [18337160] Radiology. 2008 Jul;248(1):254-63 [18566177] Int J Radiat Biol. 1998 Nov;74(5):565-71 [9848275] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-08-1691 ER - TY - JOUR T1 - The P2X7 receptor channel pore dilates under physiological ion conditions. AN - 69720257; 18852304 AB - Activation of the purinergic P2X(7) receptor leads to the rapid opening of an integral ion channel that is permeable to small cations. This is followed by a gradual increase in permeability to fluorescent dyes by integrating the actions of the pannexin-1 channel. Here, we show that during the prolonged agonist application a rapid current that peaked within 200 ms was accompanied with a slower current that required tens of seconds to reach its peak. The secondary rise in current was observed under different ionic conditions and temporally coincided with the development of conductivity to larger organic cations. The biphasic response was also observed in cells with blocked pannexin channels and in cells not expressing these channels endogenously. The biphasic current was preserved in N-terminal T15A, T15S, and T15V mutants that have low or no permeability to organic cations, reflecting enhanced permeability to inorganic cations. In contrast, the T15E, T15K, and T15W mutants, and the Delta18 mutant with deleted P2X(7) receptor-specific 18-amino acid C-terminal segment, were instantaneously permeable to organic cations and generated high amplitude monophasic currents. These results indicate that the P2X(7) receptor channel dilates under physiological ion conditions, leading to generation of biphasic current, and that this process is controlled by residues near the intracellular side of the channel pore. JF - The Journal of general physiology AU - Yan, Zonghe AU - Li, Shuo AU - Liang, Zhaodong AU - Tomić, Melanija AU - Stojilkovic, Stanko S AD - Section on Cellular Signaling, Program in Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 563 EP - 573 VL - 132 IS - 5 KW - Cations KW - 0 KW - Connexins KW - Nerve Tissue Proteins KW - P2RX7 protein, human KW - P2rx7 protein, mouse KW - PANX1 protein, human KW - Panx1 protein, mouse KW - Purinergic P2 Receptor Agonists KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2X7 KW - Index Medicus KW - Nerve Tissue Proteins -- drug effects KW - Animals KW - Ion Transport -- drug effects KW - Thermodynamics KW - Electric Conductivity KW - Particle Size KW - Humans KW - Connexins -- drug effects KW - Mice KW - Cell Line, Tumor KW - Ion Transport -- physiology KW - Structure-Activity Relationship KW - Rats KW - Mutagenesis, Site-Directed KW - Kinetics KW - Nerve Tissue Proteins -- metabolism KW - Connexins -- metabolism KW - Cell Membrane Permeability KW - Cell Line, Transformed KW - Cations -- pharmacology KW - Amino Acid Substitution KW - Ion Channel Gating -- physiology KW - Protein Interaction Domains and Motifs -- physiology KW - Protein Interaction Domains and Motifs -- drug effects KW - Receptors, Purinergic P2 -- physiology KW - Ion Channel Gating -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69720257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+physiology&rft.atitle=The+P2X7+receptor+channel+pore+dilates+under+physiological+ion+conditions.&rft.au=Yan%2C+Zonghe%3BLi%2C+Shuo%3BLiang%2C+Zhaodong%3BTomi%C4%87%2C+Melanija%3BStojilkovic%2C+Stanko+S&rft.aulast=Yan&rft.aufirst=Zonghe&rft.date=2008-11-01&rft.volume=132&rft.issue=5&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+physiology&rft.issn=1540-7748&rft_id=info:doi/10.1085%2Fjgp.200810059 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-06 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2006 Oct 27;281(43):32649-59 [16954225] Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):12063-8 [18689682] Cancer Res. 2007 Feb 15;67(4):1545-54 [17308093] Br J Pharmacol. 2000 May;130(1):167-73 [10781013] Biochim Biophys Acta. 2000 Aug 25;1467(2):444-56 [11030601] Mol Pharmacol. 2000 Nov;58(5):936-45 [11040040] Am J Physiol Cell Physiol. 2001 Apr;280(4):C943-53 [11245611] J Physiol. 2001 Jul 1;534(Pt 1):25-35 [11432989] Physiol Rev. 2002 Oct;82(4):1013-67 [12270951] J Biol Chem. 2003 Mar 7;278(10):8853-60 [12496266] Am J Physiol Cell Physiol. 2003 Aug;285(2):C467-79 [12711592] J Biol Chem. 2003 Nov 28;278(48):47554-61 [12968021] Curr Top Med Chem. 2004;4(8):821-9 [15078213] Science. 1996 May 3;272(5262):735-8 [8614837] Br J Pharmacol. 1997 Aug;121(7):1429-37 [9257924] FEBS Lett. 1997 Jul 14;411(2-3):339-45 [9271232] Neuropharmacology. 1997 Sep;36(9):1285-94 [9364483] EMBO J. 1998 Jun 1;17(11):3016-28 [9606184] Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):102-9 [10048594] Nat Neurosci. 1999 Apr;2(4):315-21 [10204537] Nat Neurosci. 1999 Apr;2(4):322-30 [10204538] J Neurochem. 2005 Feb;92(4):925-33 [15686495] Mol Pharmacol. 2005 Apr;67(4):1078-88 [15632318] J Biol Chem. 2005 Jul 22;280(29):26922-7 [15923180] Am J Physiol Cell Physiol. 2005 Nov;289(5):C1295-302 [16093280] J Physiol. 2006 Mar 15;571(Pt 3):503-17 [16423852] J Immunol. 2006 Apr 1;176(7):3877-83 [16547218] Biophys J. 2007 Apr 1;92(7):2377-91 [17189308] Biophys J. 2007 Aug 1;93(3):846-58 [17483156] Mol Pharmacol. 2007 Dec;72(6):1402-5 [17895406] EMBO J. 2006 Nov 1;25(21):5071-82 [17036048] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1085/jgp.200810059 ER - TY - JOUR T1 - Identification of the invariant chain (CD74) as an angiotensin AGTR1-interacting protein. AN - 69715297; 18719072 AB - Little is known about the protein-protein interactions that regulate the trafficking of the angiotensin II type I receptor (AGTR1) through the biosynthetic pathway. The membrane-proximal region of the cytoplasmic tail of the AGTR1 has been identified by site-directed mutagenesis studies as an essential site for normal AGTR1 folding and surface expression. Based on yeast two-hybrid screening of a human kidney cDNA library with the AGTR1 carboxyl-terminal tail as a bait, we identified the invariant chain (CD74) as a novel interacting protein. This association was confirmed by co-immunoprecipitation and co-localization studies. The binding site for CD74 on the AGTR1 carboxyl-terminal tail was localized to a site previously identified as important for the exit of the AGTR1 from the endoplasmic reticulum (ER), and conserved in many G protein-coupled receptors. Transient co-expression of CD74 with the AGTR1 in CHO-K1 cells consistently reduced the AGTR1 density at the cell surface. Furthermore, the interaction of CD74 with the carboxyl-terminal tail of the AGTR1 caused its retention in the ER and promoted its proteasomal degradation. These observations indicate that CD74 and the AGTR1 become associated in the early biosynthetic pathway, and that CD74 is a negative regulator of AGTR1 expression. JF - The Journal of endocrinology AU - Szaszák, Márta AU - Chen, Hung-Dar AU - Chen, Hao-Chia AU - Baukal, Albert AU - Hunyady, László AU - Catt, Kevin J AD - Endocrinology and Reproduction Research Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-4510, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 165 EP - 176 VL - 199 IS - 2 KW - Antigens, Differentiation, B-Lymphocyte KW - 0 KW - Histocompatibility Antigens Class II KW - Receptor, Angiotensin, Type 1 KW - invariant chain KW - Index Medicus KW - Microscopy, Confocal KW - Protein Binding -- physiology KW - Animals KW - Blotting, Western KW - Cricetulus KW - Transfection KW - Humans KW - Two-Hybrid System Techniques KW - Immunoprecipitation KW - CHO Cells KW - Cell Membrane -- metabolism KW - Cricetinae KW - Antigens, Differentiation, B-Lymphocyte -- metabolism KW - Antigens, Differentiation, B-Lymphocyte -- genetics KW - Receptor, Angiotensin, Type 1 -- genetics KW - Histocompatibility Antigens Class II -- genetics KW - Histocompatibility Antigens Class II -- metabolism KW - Receptor, Angiotensin, Type 1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69715297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+endocrinology&rft.atitle=Identification+of+the+invariant+chain+%28CD74%29+as+an+angiotensin+AGTR1-interacting+protein.&rft.au=Szasz%C3%A1k%2C+M%C3%A1rta%3BChen%2C+Hung-Dar%3BChen%2C+Hao-Chia%3BBaukal%2C+Albert%3BHunyady%2C+L%C3%A1szl%C3%B3%3BCatt%2C+Kevin+J&rft.aulast=Szasz%C3%A1k&rft.aufirst=M%C3%A1rta&rft.date=2008-11-01&rft.volume=199&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+endocrinology&rft.issn=1479-6805&rft_id=info:doi/10.1677%2FJOE-08-0190 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-10 N1 - Date created - 2008-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1677/JOE-08-0190 ER - TY - JOUR T1 - Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. AN - 69693934; 18725543 AB - Emerging evidence suggests that the rewarding, abuse-related effects of nicotine are modulated by the endocannabinoid system of the brain. For example, pharmacological blockade or genetic deletion of cannabinoid CB(1) receptors can reduce or eliminate many abuse-related behavioral and neurochemical effects of nicotine. Furthermore, doses of Delta(9)-tetrahydrocannabinol and nicotine that are ineffective when given alone can induce conditioned place preference when given together. These previous studies have used systemically administered CB(1) receptor agonists and antagonists and gene deletion techniques, which affect cannabinoid CB(1) receptors throughout the brain. A more functionally selective way to alter endocannabinoid activity is to inhibit fatty acid amide hydrolase (FAAH), thereby magnifying and prolonging the effects of the endocannabinoid anandamide only when and where it is synthesized and released on demand. Here, we combined behavioral and neurochemical approaches to evaluate whether the FAAH inhibitor URB597 (cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester) could alter the abuse-related effects of nicotine in rats. We found that URB597, at a dose (0.3 mg/kg) that had no behavioral effects by itself, prevented development of nicotine-induced conditioned place preference (CPP) and acquisition of nicotine self-administration. URB597 also reduced nicotine-induced reinstatement in both CPP and self-administration models of relapse. Furthermore, in vivo microdialysis showed that URB597 reduced nicotine-induced dopamine elevations in the nucleus accumbens shell, the terminal area of the brain's mesolimbic reward system. These findings suggest that FAAH inhibition can counteract the addictive properties of nicotine and that FAAH may serve as a new target for development of medications for treatment of tobacco dependence. JF - The Journal of pharmacology and experimental therapeutics AU - Scherma, Maria AU - Panlilio, Leigh V AU - Fadda, Paola AU - Fattore, Liana AU - Gamaleddin, Islam AU - Le Foll, Bernard AU - Justinová, Zuzana AU - Mikics, Eva AU - Haller, Jozsef AU - Medalie, Julie AU - Stroik, Jessica AU - Barnes, Chanel AU - Yasar, Sevil AU - Tanda, Gianluigi AU - Piomelli, Daniele AU - Fratta, Walter AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 482 EP - 490 VL - 327 IS - 2 KW - Arachidonic Acids KW - 0 KW - Benzamides KW - Carbamates KW - Endocannabinoids KW - Polyunsaturated Alkamides KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Nicotine KW - 6M3C89ZY6R KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - anandamide KW - UR5G69TJKH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Self Administration KW - Rats, Long-Evans KW - Reward KW - Motor Activity -- drug effects KW - Hydrolysis KW - Male KW - Carbamates -- pharmacology KW - Nucleus Accumbens -- chemistry KW - Nucleus Accumbens -- drug effects KW - Arachidonic Acids -- metabolism KW - Polyunsaturated Alkamides -- metabolism KW - Conditioning (Psychology) -- drug effects KW - Benzamides -- pharmacology KW - Tobacco Use Disorder -- drug therapy KW - Amidohydrolases -- physiology KW - Nicotine -- pharmacology KW - Dopamine -- analysis KW - Amidohydrolases -- antagonists & inhibitors KW - Tobacco Use Disorder -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69693934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Inhibition+of+anandamide+hydrolysis+by+cyclohexyl+carbamic+acid+3%27-carbamoyl-3-yl+ester+%28URB597%29+reverses+abuse-related+behavioral+and+neurochemical+effects+of+nicotine+in+rats.&rft.au=Scherma%2C+Maria%3BPanlilio%2C+Leigh+V%3BFadda%2C+Paola%3BFattore%2C+Liana%3BGamaleddin%2C+Islam%3BLe+Foll%2C+Bernard%3BJustinov%C3%A1%2C+Zuzana%3BMikics%2C+Eva%3BHaller%2C+Jozsef%3BMedalie%2C+Julie%3BStroik%2C+Jessica%3BBarnes%2C+Chanel%3BYasar%2C+Sevil%3BTanda%2C+Gianluigi%3BPiomelli%2C+Daniele%3BFratta%2C+Walter%3BGoldberg%2C+Steven+R&rft.aulast=Scherma&rft.aufirst=Maria&rft.date=2008-11-01&rft.volume=327&rft.issue=2&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.142224 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nicotine Tob Res. 1999;1 Suppl 2:S121-5; 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AN - 69693802; 18701886 AB - For the first time, relationships among maternal buprenorphine dose, meconium buprenorphine and metabolite concentrations, and neonatal outcomes are reported. Free and total buprenorphine and norbuprenorphine, nicotine, opiates, cocaine, benzodiazepines, and metabolites were quantified in meconium from 10 infants born to women who had received buprenorphine during pregnancy. Neither cumulative nor total third-trimester maternal buprenorphine dose predicted meconium concentrations or neonatal outcomes. Total buprenorphine meconium concentrations and buprenorphine/norbuprenorphine ratios were significantly related to neonatal abstinence syndrome (NAS) scores >4. As free buprenorphine concentration and percentage free buprenorphine increased, head circumference decreased. Thrice-weekly urine tests for opiates, cocaine, and benzodiazepines and self-reported smoking data from the mother were compared with data from analysis of the meconium to estimate in utero exposure. Time of last drug use and frequency of use during the third trimester were important factors associated with drug-positive meconium specimens. The results suggest that buprenorphine and metabolite concentrations in the meconium may predict the onset and frequency of NAS. JF - Clinical pharmacology and therapeutics AU - Kacinko, S L AU - Jones, H E AU - Johnson, R E AU - Choo, R E AU - Huestis, M A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 604 EP - 612 VL - 84 IS - 5 KW - Narcotic Antagonists KW - 0 KW - Opiate Alkaloids KW - Buprenorphine KW - 40D3SCR4GZ KW - Nicotine KW - 6M3C89ZY6R KW - Cocaine KW - I5Y540LHVR KW - Methadone KW - UC6VBE7V1Z KW - Abridged Index Medicus KW - Index Medicus KW - Maternal Behavior KW - Methadone -- therapeutic use KW - Double-Blind Method KW - Humans KW - Infant, Newborn KW - Neonatal Abstinence Syndrome -- diagnosis KW - Neonatal Abstinence Syndrome -- drug therapy KW - Pregnancy KW - Maternal-Fetal Exchange KW - Adult KW - Smoking -- metabolism KW - Female KW - Male KW - Buprenorphine -- metabolism KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Cocaine -- urine KW - Nicotine -- metabolism KW - Meconium -- chemistry KW - Opioid-Related Disorders -- rehabilitation KW - Opioid-Related Disorders -- urine KW - Narcotic Antagonists -- metabolism KW - Opioid-Related Disorders -- drug therapy KW - Opiate Alkaloids -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69693802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Correlations+of+maternal+buprenorphine+dose%2C+buprenorphine%2C+and+metabolite+concentrations+in+meconium+with+neonatal+outcomes.&rft.au=Kacinko%2C+S+L%3BJones%2C+H+E%3BJohnson%2C+R+E%3BChoo%2C+R+E%3BHuestis%2C+M+A&rft.aulast=Kacinko&rft.aufirst=S&rft.date=2008-11-01&rft.volume=84&rft.issue=5&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2008.156 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-05 N1 - Date created - 2008-10-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pediatr. 1994 Mar;124(3):477-9 [8120725] J Forensic Sci. 1994 Jan;39(1):150-8 [8113697] J Perinatol. 1995 May-Jun;15(3):199-202 [7666268] Clin Chem. 1997 Jan;43(1):235-42 [8990259] Forensic Sci Int. 1997 Jan 17;84(1-3):129-35 [9042717] Clin Pharmacol Ther. 1997 Nov;62(5):569-71 [9390114] J Child Adolesc Psychopharmacol. 1998;8(3):161-74 [9853690] Drug Metab Dispos. 2005 May;33(5):689-95 [15743975] Drug Alcohol Depend. 2005 Jul;79(1):1-10 [15943939] J Perinatol. 2006 Jan 1;26(1):15-7 [16355103] Addiction. 2006 Feb;101(2):275-81 [16445556] Drug Metab Dispos. 2006 Apr;34(4):636-46 [16443669] Drug Alcohol Depend. 2006 May 20;82(3):250-7 [16257138] Eur J Neurosci. 2007 Feb;25(3):611-7 [17298594] Expert Opin Drug Metab Toxicol. 2007 Jun;3(3):331-46 [17539742] Obstet Gynecol Surv. 2007 Nov;62(11):749-57 [17925048] Anal Chem. 2008 Jan 1;80(1):246-52 [18044957] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):107-14 [18243821] Pharmacol Ther. 1999 Dec;84(3):429-45 [10665839] Addiction. 2000 Feb;95(2):239-44 [10723852] Pediatrics. 2001 Feb;107(2):309-17 [11158464] Z Geburtshilfe Neonatol. 2001 Nov-Dec;205(6):224-30 [11745008] J Pharmacol Exp Ther. 2002 Jan;300(1):26-33 [11752093] Biochem Pharmacol. 2002 Feb 1;63(3):409-19 [11853692] J Perinat Neonatal Nurs. 2001 Mar;14(4):61-82; quiz 105-6 [11930523] Anal Biochem. 2002 Jul 1;306(1):31-9 [12069411] Hum Reprod. 2002 Oct;17(10):2564-72 [12351530] Int J Neuropsychopharmacol. 2003 Mar;6(1):57-72 [12899737] Drug Alcohol Depend. 2004 Sep 6;75(3):253-60 [15283946] Pediatrics. 2004 Aug;114(2):e226-34 [15286261] Neurobehav Toxicol Teratol. 1986 Jul-Aug;8(4):353-5 [3762845] Pediatrics. 1992 Jan;89(1):107-13 [1727992] J Pediatr. 1994 Sep;125(3):435-40 [8071754] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2008.156 ER - TY - JOUR T1 - Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment. AN - 69691539; 18682571 AB - Cytochrome P450s (P450s) are important enzymes involved in the metabolism of xenobiotics, particularly clinically used drugs, and are also responsible for metabolic activation of chemical carcinogens and toxins. Many xenobiotics can activate nuclear receptors that in turn induce the expression of genes encoding xenobiotic metabolizing enzymes and drug transporters. Marked species differences in the expression and regulation of cytochromes P450 and xenobiotic nuclear receptors exist. Thus, obtaining reliable rodent models to accurately reflect human drug and carcinogen metabolism is severely limited. Humanized transgenic mice were developed in an effort to create more reliable in vivo systems to study and predict human responses to xenobiotics. Human P450s or human xenobiotic-activated nuclear receptors were introduced directly or replaced the corresponding mouse gene, thus creating "humanized" transgenic mice. Mice expressing human CYP1A1/CYP1A2, CYP2E1, CYP2D6, CYP3A4, CY3A7, pregnane X receptor, and peroxisome proliferator-activated receptor alpha were generated and characterized. These humanized mouse models offer a broad utility in the evaluation and prediction of toxicological risk that may aid in the development of safer drugs. JF - The Journal of pharmacology and experimental therapeutics AU - Cheung, Connie AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, 9000 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 288 EP - 299 VL - 327 IS - 2 KW - PPAR alpha KW - 0 KW - Pharmaceutical Preparations KW - Receptors, Steroid KW - pregnane X receptor KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A2 KW - Cytochrome P-450 CYP2D6 KW - Cytochrome P-450 CYP3A KW - Index Medicus KW - Cytochrome P-450 CYP1A2 -- physiology KW - Animals KW - Receptors, Steroid -- physiology KW - Humans KW - Cytochrome P-450 CYP3A -- physiology KW - PPAR alpha -- physiology KW - Mice KW - Cytochrome P-450 CYP2E1 -- physiology KW - Mice, Transgenic KW - Cytochrome P-450 CYP2D6 -- physiology KW - Species Specificity KW - Cytochrome P-450 CYP1A1 -- physiology KW - Pharmaceutical Preparations -- metabolism KW - Cytochrome P-450 Enzyme System -- physiology KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69691539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Humanized+mouse+lines+and+their+application+for+prediction+of+human+drug+metabolism+and+toxicological+risk+assessment.&rft.au=Cheung%2C+Connie%3BGonzalez%2C+Frank+J&rft.aulast=Cheung&rft.aufirst=Connie&rft.date=2008-11-01&rft.volume=327&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.108.141242 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-11-13 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2008 Feb;36(2):435-41 [18048490] Toxicology. 2008 Apr 3;246(1):9-17 [18248870] Drug Metab Dispos. 2008 May;36(5):955-62 [18276835] Clin Pharmacol Ther. 2008 Jun;83(6):818-28 [18388875] J Exp Med. 2008 Jun 9;205(6):1409-22 [18474629] Toxicology. 1995 Dec 15;104(1-3):1-8 [8560487] J Pharmacol Exp Ther. 1997 Sep;282(3):1435-41 [9316857] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] Mol Pharmacol. 1998 Jan;53(1):14-22 [9443928] Cell. 1998 Jan 9;92(1):73-82 [9489701] J Clin Invest. 1998 Sep 1;102(5):1016-23 [9727070] J Natl Cancer Inst. 1998 Nov 18;90(22):1702-9 [9827524] Annu Rev Pharmacol Toxicol. 1999;39:1-17 [10331074] Cancer Lett. 1999 Sep 1;143(2):149-55 [10503895] Drug Metab Rev. 2004 Oct;36(3-4):497-509 [15554232] Hum Mutat. 2005 Feb;25(2):196-206 [15643613] Drug Metab Dispos. 2005 Mar;33(3):449-57 [15576447] Endocrinology. 2005 Jul;146(7):2911-9 [15817670] Drug Metab Dispos. 2005 Jul;33(7):892-5 [15845749] Chem Res Toxicol. 2005 Sep;18(9):1471-8 [16167840] Annu Rev Pharmacol Toxicol. 2006;46:41-64 [16402898] Mol Endocrinol. 2000 Jan;14(1):27-39 [10628745] Clin Pharmacokinet. 2000 Jan;38(1):41-57 [10668858] Drug Metab Dispos. 2000 Mar;28(3):268-78 [10681370] Nature. 2000 Jul 27;406(6794):435-9 [10935643] Arch Pharm Res. 2000 Oct;23(5):513-7 [11059833] Pharmacogenetics. 2001 Feb;11(1):1-6 [11207026] Xenobiotica. 2000 Dec;30(12):1131-52 [11307970] Bioorg Med Chem Lett. 2001 May 7;11(9):1225-7 [11354382] Am J Physiol Gastrointest Liver Physiol. 2001 Dec;281(6):G1333-9 [11705737] Mol Pharmacol. 2001 Dec;60(6):1260-7 [11723233] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1259-66 [11751443] Environ Mol Mutagen. 2002;39(2-3):165-70 [11921185] Hepatology. 2002 Jul;36(1):122-34 [12085356] Nat Rev Drug Discov. 2002 Apr;1(4):259-66 [12120277] J Pharmacol Exp Ther. 2002 Oct;303(1):412-23 [12235278] Drug Metab Dispos. 2003 May;31(5):548-58 [12695342] Pharmacogenetics. 2003 Jun;13(6):307-19 [12777961] J Nutr. 2003 Jul;133(7 Suppl):2444S-2447S [12840222] Hepatology. 2003 Oct;38(4):978-88 [14512885] Curr Mol Med. 2003 Sep;3(6):509-18 [14527082] Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):23-37 [14618296] Annu Rev Pharmacol Toxicol. 2004;44:27-42 [14744237] Mol Interv. 2003 Jun;3(4):194-204 [14993447] Pharmacogenetics. 2004 Jan;14(1):1-18 [15128046] J Biol Chem. 2004 Jun 4;279(23):23847-50 [15028720] Cancer Res. 2004 Jun 1;64(11):3849-54 [15172993] J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):139-42 [15225761] Am J Pathol. 2004 Sep;165(3):901-12 [15331414] Science. 1975 Nov 21;190(4216):787-9 [1198095] Lancet. 1977 Sep 17;2(8038):584-6 [71400] Drug Metab Rev. 1981;12(2):221-37 [7040014] Cancer Res. 1982 Nov;42(11):4712-8 [7127306] Chem Res Toxicol. 1992 Sep-Oct;5(5):691-7 [1446011] Biochemistry. 1993 Jun 1;32(21):5598-604 [7684926] Biochem Pharmacol. 1994 Apr 29;47(9):1643-53 [8185679] Chem Res Toxicol. 1994 Nov-Dec;7(6):733-9 [7696526] Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Clin Pharmacol Ther. 1996 Jan;59(1):7-13 [8549036] J Biol Chem. 1996 May 17;271(20):12063-7 [8662637] Physiol Rev. 1997 Apr;77(2):517-44 [9114822] J Pharmacol Exp Ther. 2006 Mar;316(3):1328-34 [16291874] Carcinogenesis. 2006 May;27(5):1074-80 [16377806] Mol Endocrinol. 2006 Nov;20(11):2613-29 [16543404] Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):875-94 [17125407] Arch Biochem Biophys. 2007 Jan 1;457(1):105-10 [17107656] Drug Metab Dispos. 2007 Feb;35(2):194-200 [17093002] Biochem Biophys Res Commun. 2007 Aug 3;359(3):635-42 [17560947] J Clin Invest. 2007 Nov;117(11):3583-92 [17975676] Toxicol Sci. 2008 Jan;101(1):132-9 [17690133] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.108.141242 ER - TY - JOUR T1 - One SNP linked to two diseases-addiction and cancer: a double whammy? Nicotine addiction and lung cancer susceptibility. AN - 69688136; 18936755 JF - Molecular psychiatry AU - Volkow, N AU - Rutter, J AU - Pollock, J D AU - Shurtleff, D AU - Baler, R AD - Office of the Director, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 990 EP - 992 VL - 13 IS - 11 KW - Protein Subunits KW - 0 KW - Receptors, Nicotinic KW - Index Medicus KW - Protein Subunits -- genetics KW - Humans KW - Tobacco Use Disorder -- genetics KW - Lung Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Receptors, Nicotinic -- genetics KW - Polymorphism, Single Nucleotide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69688136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+psychiatry&rft.atitle=One+SNP+linked+to+two+diseases-addiction+and+cancer%3A+a+double+whammy%3F+Nicotine+addiction+and+lung+cancer+susceptibility.&rft.au=Volkow%2C+N%3BRutter%2C+J%3BPollock%2C+J+D%3BShurtleff%2C+D%3BBaler%2C+R&rft.aulast=Volkow&rft.aufirst=N&rft.date=2008-11-01&rft.volume=13&rft.issue=11&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=Molecular+psychiatry&rft.issn=1476-5578&rft_id=info:doi/10.1038%2Fmp.2008.71 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-04-08 N1 - Date created - 2008-10-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/mp.2008.71 ER - TY - JOUR T1 - Catalytic mechanism of human DNA polymerase lambda with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies. AN - 69674916; 18692600 AB - DNA polymerases play a crucial role in the cell cycle due to their involvement in genome replication and repair. Understanding the reaction mechanism by which these polymerases carry out their function can provide insights into these processes. Recently, the crystal structures of human DNA polymerase lambda (Pollambda) have been reported both for pre- and post-catalytic complexes [García-Díaz et al., DNA Repair 3 (2007), 1333]. Here we employ the pre-catalytic complex as a starting structure for the determination of the catalytic mechanism of Pollambda using ab initio quantum mechanical/molecular mechanical methods. The reaction path has been calculated using Mg(2+) and Mn(2+) as the catalytic metals. In both cases the reaction proceeds through a two-step mechanism where the 3'-OH of the primer sugar ring is deprotonated by one of the conserved Asp residues (D490) in the active site before the incorporation of the nucleotide to the nascent DNA chain. A significant charge transfer is observed between both metals and some residues in the active site as the reaction proceeds. The optimized reactant and product structures agree with the reported crystal structures. In addition, the calculated reaction barriers for both metals are close to experimentally estimated barriers. Energy decomposition analysis to explain individual residue contributions suggests that several amino acids surrounding the active site are important for catalysis. Some of these residues, including R420, R488 and E529, have been implicated in catalysis by previous mutagenesis experiments on the homologous residues on Polbeta. Furthermore, Pollambda residues R420 and E529 found to be important from the energy decomposition analysis, are homologous to residues R183 and E295 in Polbeta, both of which are linked to cancer. In addition, residues R386, E391, K422 and K472 appear to have an important role in catalysis and could be a potential target for mutagenesis experiments. There is partial conservation of these residues across the Pol X family of DNA polymerases. JF - DNA repair AU - Cisneros, G Andrés AU - Perera, Lalith AU - García-Díaz, Miguel AU - Bebenek, Katarzyna AU - Kunkel, Thomas A AU - Pedersen, Lee G AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park (RTP), NC 27709, USA. cisnero1@niehs.nih.gov Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 1824 EP - 1834 VL - 7 IS - 11 SN - 1568-7864, 1568-7864 KW - Manganese KW - 42Z2K6ZL8P KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA polymerase beta2 KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Catalytic Domain KW - Crystallography, X-Ray KW - Amino Acid Sequence KW - Molecular Conformation KW - Sequence Homology, Amino Acid KW - Models, Biological KW - Protein Conformation KW - Mutagenesis KW - Catalysis KW - Manganese -- chemistry KW - Magnesium -- chemistry KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69674916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Catalytic+mechanism+of+human+DNA+polymerase+lambda+with+Mg2%2B+and+Mn2%2B+from+ab+initio+quantum+mechanical%2Fmolecular+mechanical+studies.&rft.au=Cisneros%2C+G+Andr%C3%A9s%3BPerera%2C+Lalith%3BGarc%C3%ADa-D%C3%ADaz%2C+Miguel%3BBebenek%2C+Katarzyna%3BKunkel%2C+Thomas+A%3BPedersen%2C+Lee+G&rft.aulast=Cisneros&rft.aufirst=G&rft.date=2008-11-01&rft.volume=7&rft.issue=11&rft.spage=1824&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2008.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-29 N1 - Date created - 2008-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Chem Phys. 2006 Feb 7;124(5):054109 [16468853] Chem Rev. 2006 Feb;106(2):340-60 [16464009] Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13294-9 [16938895] Biophys J. 2006 Nov 1;91(9):3182-95 [16920835] Biochem Biophys Res Commun. 2006 Nov 24;350(3):521-9 [17022941] Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4267-72 [17360513] J Am Chem Soc. 2007 Apr 18;129(15):4731-7 [17375926] Biochemistry. 2007 May 8;46(18):5463-72 [17419590] DNA Repair (Amst). 2007 Jun 1;6(6):869-75 [17363341] J Mol Graph Model. 2007 Jul;26(1):1-13 [17046299] DNA Repair (Amst). 2007 Sep 1;6(9):1333-40 [17475573] J Am Chem Soc. 2007 Sep 12;129(36):11100-10 [17696533] DNA Repair (Amst). 2007 Dec 1;6(12):1709-25 [17631059] J Phys Chem B. 2008 Jan 24;112(3):1007-15 [18166038] J Am Chem Soc. 2008 Mar 26;130(12):3967-77 [18307346] Annu Rev Phys Chem. 2008;59:573-601 [18393679] Mol Cell. 2008 May 9;30(3):315-24 [18471977] Mutat Res. 1999 Oct 22;435(2):121-8 [10556592] J Mol Biol. 2000 Sep 8;302(1):205-17 [10964570] Acc Chem Res. 2001 Jan;34(1):72-9 [11170358] Biometals. 2002 Sep;15(3):225-35 [12206389] J Phys Chem B. 2007 Sep 27;111(38):11244-52 [17764165] Cancer Cell. 2003 Feb;3(2):105-10 [12620405] Biochemistry. 2003 Jun 24;42(24):7467-76 [12809503] J Am Chem Soc. 2003 Jul 9;125(27):8163-77 [12837086] J Comput Chem. 2003 Sep;24(12):1514-27 [12868114] J Am Chem Soc. 2003 Aug 27;125(34):10384-93 [12926963] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] Nucleic Acids Res. 2003 Dec 1;31(23):6916-25 [14627824] Biochemistry. 2004 Jun 1;43(21):6751-62 [15157109] J Chem Phys. 2004 Jul 8;121(2):697-706 [15260596] J Chem Phys. 2004 May 1;120(17):8039-52 [15267723] Cell Cycle. 2004 Aug;3(8):998-1001 [15280658] J Mol Biol. 1976 May 15;103(2):227-49 [985660] Nature. 1977 Jun 16;267(5612):585-90 [301613] Biochemistry. 1990 May 29;29(21):5027-34 [2198936] Biochemistry. 1995 Dec 12;34(49):15934-42 [8519750] Adv Protein Chem. 2004;69:137-65 [15588842] Nat Struct Mol Biol. 2005 Jan;12(1):97-8 [15608652] J Am Chem Soc. 2005 Mar 23;127(11):4010-20 [15771538] J Chem Phys. 2005 Mar 15;122(11):114502 [15836224] J Biol Chem. 2005 May 6;280(18):18469-75 [15749700] Proc Natl Acad Sci U S A. 2005 May 10;102(19):6819-24 [15863620] J Biol Chem. 2005 Sep 9;280(36):31641-7 [16002405] Nucleic Acids Res. 2005;33(16):5354-61 [16174846] J Comput Chem. 2005 Dec;26(16):1668-88 [16200636] DNA Repair (Amst). 2005 Dec 8;4(12):1358-67 [16213194] Cell. 2006 Jan 27;124(2):331-42 [16439207] Chem Rev. 2006 Aug;106(8):3210-35 [16895325] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.dnarep.2008.07.007 ER - TY - JOUR T1 - Ethanol regulation of D(1) dopamine receptor signaling is mediated by protein kinase C in an isozyme-specific manner. AN - 69672653; 18288091 AB - Ethanol consumption potentiates dopaminergic signaling that is partially mediated by the D(1) dopamine receptor; however, the mechanism(s) underlying ethanol-dependent modulation of D(1) signaling is unclear. We now show that ethanol treatment of D(1) receptor-expressing cells decreases D(1) receptor phosphorylation and concurrently potentiates dopamine-stimulated cAMP accumulation. Protein kinase C (PKC) inhibitors mimic the effects of ethanol on D(1) receptor phosphorylation and dopamine-stimulated cAMP levels in a manner that is non-additive with ethanol treatment. Ethanol was also found to modulate specific PKC activities as demonstrated using in vitro kinase assays where ethanol treatment attenuated the activities of lipid-stimulated PKCgamma and PKCdelta in membrane fractions, but did not affect the activities of PKCalpha, PKCbeta(1), or PKCvarepsilon. Importantly, ethanol treatment potentiated D(1) receptor-mediated DARPP-32 phosphorylation in rat striatal slices, supporting the notion that ethanol enhances D(1) receptor signaling in vivo. These findings suggest that ethanol inhibits the activities of specific PKC isozymes, resulting in decreased D(1) receptor phosphorylation and enhanced dopaminergic signaling. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Rex, Elizabeth B AU - Rankin, Michele L AU - Ariano, Marjorie A AU - Sibley, David R AD - Molecular Neuropharmacology Section, National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 2900 EP - 2911 VL - 33 IS - 12 KW - Central Nervous System Depressants KW - 0 KW - Dopamine and cAMP-Regulated Phosphoprotein 32 KW - Enzyme Inhibitors KW - Isoenzymes KW - Ppp1r1b protein, rat KW - Receptors, Dopamine D1 KW - Ethanol KW - 3K9958V90M KW - Cyclic AMP KW - E0399OZS9N KW - protein kinase C gamma KW - EC 2.7.1.- KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C-delta KW - Index Medicus KW - Animals KW - Protein Kinase C-delta -- metabolism KW - Humans KW - Brain Chemistry -- drug effects KW - Isoenzymes -- drug effects KW - Protein Kinase C-delta -- antagonists & inhibitors KW - Isoenzymes -- metabolism KW - Phosphorylation -- drug effects KW - Alcohol-Induced Disorders, Nervous System -- physiopathology KW - Rats KW - Central Nervous System Depressants -- pharmacology KW - Alcohol-Induced Disorders, Nervous System -- metabolism KW - Down-Regulation -- physiology KW - Dopamine and cAMP-Regulated Phosphoprotein 32 -- metabolism KW - Dopamine and cAMP-Regulated Phosphoprotein 32 -- drug effects KW - Cyclic AMP -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Down-Regulation -- drug effects KW - Cell Line KW - Brain Chemistry -- physiology KW - Protein Kinase C -- metabolism KW - Signal Transduction -- physiology KW - Brain -- enzymology KW - Protein Kinase C -- antagonists & inhibitors KW - Ethanol -- pharmacology KW - Brain -- drug effects KW - Signal Transduction -- drug effects KW - Receptors, Dopamine D1 -- drug effects KW - Receptors, Dopamine D1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69672653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Ethanol+regulation+of+D%281%29+dopamine+receptor+signaling+is+mediated+by+protein+kinase+C+in+an+isozyme-specific+manner.&rft.au=Rex%2C+Elizabeth+B%3BRankin%2C+Michele+L%3BAriano%2C+Marjorie+A%3BSibley%2C+David+R&rft.aulast=Rex&rft.aufirst=Elizabeth&rft.date=2008-11-01&rft.volume=33&rft.issue=12&rft.spage=2900&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.16 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.16 ER - TY - JOUR T1 - Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant. AN - 69671876; 18305459 AB - Accumulating evidence suggests the endocannabinoid system modulates environmental cues' ability to induce seeking of drugs, including nicotine and alcohol. However, little attention has been directed toward extending these advances to the growing problem of cannabis use disorders. Therefore, we studied intravenous self-administration of Delta(9)-tetrahydrocannabinol (THC), the main psychoactive constituent of marijuana, using a second-order schedule of drug seeking. Squirrel monkeys' lever responses produced only a brief cue light until the end of the session, when the final response delivered THC along with the cue. When a reinstatement procedure was used to model relapse following a period of abstinence, THC-seeking behavior was robustly reinstated by the cue or by pre-session administration of THC, other cannabinoid agonists, or morphine, but not cocaine. The cannabinoid antagonist rimonabant blocked cue-induced drug seeking, THC-induced drug seeking, and the direct reinforcing effects of THC. Thus, rimonabant and related medications might be effective as treatments for cannabinoid dependence. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Justinova, Zuzana AU - Munzar, Patrik AU - Panlilio, Leigh V AU - Yasar, Sevil AU - Redhi, Godfrey H AU - Tanda, Gianluigi AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Department of Health and Human Services, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 2870 EP - 2877 VL - 33 IS - 12 KW - Analgesics, Opioid KW - 0 KW - Cannabinoid Receptor Modulators KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Morphine KW - 76I7G6D29C KW - Dronabinol KW - 7J8897W37S KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Reinforcement (Psychology) KW - Disease Models, Animal KW - Cannabinoid Receptor Modulators -- antagonists & inhibitors KW - Morphine -- pharmacology KW - Saimiri KW - Cannabinoid Receptor Modulators -- agonists KW - Self Administration KW - Cannabinoid Receptor Modulators -- metabolism KW - Analgesics, Opioid -- pharmacology KW - Cues KW - Secondary Prevention KW - Male KW - Piperidines -- pharmacology KW - Brain -- physiopathology KW - Pyrazoles -- pharmacology KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Marijuana Abuse -- metabolism KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - Marijuana Abuse -- drug therapy KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Brain -- metabolism KW - Marijuana Abuse -- physiopathology KW - Dronabinol -- antagonists & inhibitors KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69671876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Blockade+of+THC-seeking+behavior+and+relapse+in+monkeys+by+the+cannabinoid+CB%281%29-receptor+antagonist+rimonabant.&rft.au=Justinova%2C+Zuzana%3BMunzar%2C+Patrik%3BPanlilio%2C+Leigh+V%3BYasar%2C+Sevil%3BRedhi%2C+Godfrey+H%3BTanda%2C+Gianluigi%3BGoldberg%2C+Steven+R&rft.aulast=Justinova&rft.aufirst=Zuzana&rft.date=2008-11-01&rft.volume=33&rft.issue=12&rft.spage=2870&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2008.21 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-02-20 N1 - Date created - 2008-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2006 Aug 16;26(33):8531-6 [16914679] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Brain Res Rev. 2007 Jan;53(1):1-16 [16839608] Behav Pharmacol. 2007 Feb;18(1):61-9 [17218798] Eur J Neurosci. 2007 Apr;25(7):2191-200 [17419755] Psychopharmacology (Berl). 2005 May;179(2):452-60 [15821957] J Neurosci. 2005 Jun 8;25(23):5645-50 [15944392] Pharmacol Biochem Behav. 2005 Jun;81(2):285-99 [15932767] Pharmacol Biochem Behav. 2005 Jun;81(2):387-95 [15935455] Trends Pharmacol Sci. 2005 Aug;26(8):420-6 [15992935] Psychopharmacology (Berl). 2006 Jan;183(4):394-403 [16261315] Trends Neurosci. 2006 Apr;29(4):225-32 [16483675] Addiction. 2007 Dec;102(12):1863-70 [18031422] Nat Neurosci. 2000 Nov;3(11):1073-4 [11036260] Behav Pharmacol. 2000 Aug;11(5):377-86 [11103889] Psychopharmacology (Berl). 2000 Dec;153(1):17-30 [11255926] J Neurosci. 2001 Jul 15;21(14):5344-50 [11438610] Nat Med. 2001 Oct;7(10):1151-4 [11590440] Psychopharmacology (Berl). 2002 Oct;163(3-4):327-44 [12373434] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] J Pharmacol Exp Ther. 2003 Jul;306(1):93-102 [12660305] Psychopharmacology (Berl). 2003 Jul;168(1-2):164-9 [12669182] Psychopharmacology (Berl). 2003 Sep;169(2):135-40 [12827345] Psychopharmacology (Berl). 2004 Apr;173(1-2):186-94 [14668977] JAMA. 2004 May 5;291(17):2114-21 [15126440] Br J Pharmacol. 2004 Oct;143(3):343-50 [15339858] J Pharmacol Exp Ther. 1973 Jul;186(1):18-30 [4198773] Fed Proc. 1975 Aug;34(9):1771-6 [1149889] Psychopharmacology (Berl). 1977 Mar 16;51(3):235-42 [403538] Psychopharmacology (Berl). 1998 Dec;140(3):331-44 [9877013] Pharmacol Biochem Behav. 1999 Oct;64(2):327-36 [10515309] Neuropsychopharmacology. 2006 Dec;31(12):2652-9 [16541083] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/npp.2008.21 ER - TY - JOUR T1 - Dynamic interaction between Arf GAP and PH domains of ASAP1 in the regulation of GAP activity. AN - 69665564; 18675341 AB - ASAP family Arf GAPs induce the hydrolysis of GTP bound to the Ras superfamily protein Arf1, regulate cell adhesion and migration and have been implicated in carcinogenesis. The ASAP proteins have a core catalytic domain of PH, Arf GAP and Ank repeat domains. The PH domain is necessary for both biological and catalytic functions of ASAP1 and has been proposed to be integrally folded with the Arf GAP domain. Protection studies and analytical ultracentrifugation studies previously reported indicated that the domains are, at least partly, folded together. Here, using NMR spectroscopy and biochemical analysis, we have further tested this hypothesis and characterized the interdomain interaction. A comparison of NMR spectra of three recombinant proteins comprised of either the isolated PH domain of ASAP1, the Arf GAP and ankyrin repeat domain or all three domains indicated that the PH domain did interact with the Arf GAP and Ank repeat domains; however, we found a significant amount of dynamic independence between the PH and Arf GAP domains, consistent with the interactions being transient. In contrast, the Arf GAP and Ank repeat domains form a relatively rigid structure. The PH-Arf GAP domain interaction partially occluded the phosphoinositide binding site in the soluble protein, but binding studies indicated the PIP2 binding site was accessible in ASAP1 bound to a lipid bilayer surface. Phosphoinositide binding altered the conformation of the PH domain, but had little effect on the structure of the Arf GAP domain. Mutations in a loop of the PH domain that contacts the Arf GAP domain affected PIP2 binding and the K(m) and k(cat) for converting Arf1 GTP to Arf1 GDP. Based on these results, we generated a homology model of a composite PH/Arf GAP/Ank repeat domain structure. We propose that the PH domain contributes to Arf GAP activity by either binding to or positioning Arf1 GTP that is simultaneously bound to the Arf GAP domain. JF - Cellular signalling AU - Luo, Ruibai AU - Miller Jenkins, Lisa M AU - Randazzo, Paul A AU - Gruschus, James AD - Laboratory of Cellular and Molecular Biology, National Institutes of Health, Bethesda, MD 20892, United Sates. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1968 EP - 1977 VL - 20 IS - 11 SN - 0898-6568, 0898-6568 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - GTPase-Activating Proteins KW - Inositol Phosphates KW - Lipid Bilayers KW - Phosphatidylinositol 4,5-Diphosphate KW - Phospholipids KW - ADP-Ribosylation Factors KW - EC 3.6.5.2 KW - Index Medicus KW - Protein Structure, Secondary KW - Models, Molecular KW - Inositol Phosphates -- metabolism KW - Phospholipids -- metabolism KW - Mutation -- genetics KW - Protein Structure, Tertiary KW - Protein Binding KW - Phosphatidylinositol 4,5-Diphosphate -- metabolism KW - Lipid Bilayers -- metabolism KW - Magnetic Resonance Spectroscopy KW - Catalysis KW - Binding Sites KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Adaptor Proteins, Signal Transducing -- chemistry KW - GTPase-Activating Proteins -- metabolism KW - ADP-Ribosylation Factors -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69665564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+signalling&rft.atitle=Dynamic+interaction+between+Arf+GAP+and+PH+domains+of+ASAP1+in+the+regulation+of+GAP+activity.&rft.au=Luo%2C+Ruibai%3BMiller+Jenkins%2C+Lisa+M%3BRandazzo%2C+Paul+A%3BGruschus%2C+James&rft.aulast=Luo&rft.aufirst=Ruibai&rft.date=2008-11-01&rft.volume=20&rft.issue=11&rft.spage=1968&rft.isbn=&rft.btitle=&rft.title=Cellular+signalling&rft.issn=08986568&rft_id=info:doi/10.1016%2Fj.cellsig.2008.07.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-03 N1 - Date created - 2008-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2003 Jun 6;278(23):21099-104 [12657629] J Biol Chem. 2003 May 16;278(20):18393-400 [12637522] Dev Cell. 2003 Sep;5(3):513-21 [12967569] Cell Signal. 2004 Sep;16(9):1033-44 [15212764] EMBO J. 2004 Oct 13;23(20):3918-28 [15457207] Eur J Biochem. 1991 Dec 5;202(2):569-74 [1761056] J Biomol NMR. 1993 Mar;3(2):185-204 [8477186] Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):816-20 [7846058] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] Science. 1995 Dec 22;270(5244):1999-2002 [8533093] Structure. 1995 Nov 15;3(11):1185-95 [8591029] Cell. 1996 May 31;85(5):621-4 [8646770] Mol Cell Biol. 1998 Dec;18(12):7038-51 [9819391] J Magn Reson. 1999 Oct;140(2):451-9 [10497050] J Biol Chem. 2005 Mar 11;280(10):8884-92 [15632162] EMBO J. 2005 Mar 9;24(5):963-73 [15719014] Clin Cancer Res. 2005 May 15;11(10):3609-13 [15897555] Cell Signal. 2005 Oct;17(10):1276-88 [16038802] J Cell Sci. 2005 Aug 1;118(Pt 15):3555-66 [16079295] Curr Biol. 2005 Dec 6;15(23):2164-9 [16332543] Methods Enzymol. 2005;404:147-63 [16413266] Methods Enzymol. 2005;404:164-74 [16413267] Curr Biol. 2006 Jan 24;16(2):130-9 [16431365] J Cell Sci. 2006 Apr 1;119(Pt 7):1203-11 [16554436] J Biomol NMR. 2006;36 Suppl 1:21 [16642402] Biochemistry. 2006 Dec 26;45(51):15301-9 [17176052] Biochem J. 2007 Mar 15;402(3):439-47 [17112341] J Biol Chem. 2007 Apr 13;282(15):11356-64 [17277311] EMBO J. 2007 Jul 25;26(14):3484-93 [17581628] Biol Cell. 2007 Oct;99(10):583-600 [17868031] Traffic. 2007 Nov;8(11):1465-75 [17666108] Traffic. 2007 Nov;8(11):1644-55 [17760859] Mol Cell Biol. 2007 Dec;27(23):8271-83 [17893324] J Biol Chem. 1994 Apr 8;269(14):10758-63 [8144664] EMBO J. 1999 Dec 15;18(24):6890-8 [10601011] J Biol Chem. 2000 Mar 31;275(13):9653-63 [10734117] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4011-6 [10725410] Methods Enzymol. 2001;329:343-54 [11210554] EMBO J. 2002 Mar 15;21(6):1315-26 [11889037] FEBS Lett. 2002 Feb 20;513(1):71-6 [11911883] Mol Biol Cell. 2002 Jun;13(6):2147-56 [12058076] Genome Res. 2002 Nov;12(11):1625-41 [12421749] J Struct Biol. 2003 Jan;141(1):63-76 [12576021] Traffic. 2003 Apr;4(4):201-13 [12694559] Curr Opin Cell Biol. 2003 Aug;15(4):396-404 [12892779] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cellsig.2008.07.007 ER - TY - JOUR T1 - A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. AN - 69656854; 17524525 AB - Young male Fischer-344 rats were fed a diet containing 2% blueberry (BB) extract or control diet for at least 8 weeks and then received bilateral hippocampal injections of kainic acid (KA 200 ng/0.5 microl) or phosphate buffered saline (PBS). One week later rats were trained in one-way active footshock avoidance in a straight runway followed the next day by training in a footshock motivated 14-unit T-maze with documented sensitivity to hippocampal glutamatergic manipulations. Based on analyses of several performance variables, KA-treated rats exhibited clearly impaired learning performance; however, the BB diet significantly reduced this impairment. Supporting the behavioral findings, stereological assessment of CA1 pyramidal neurons documented greater neuronal loss in KA-treated controls compared to KA-treated rats on the BB diet. In an in vitro experiment, FaO cells grown in medium supplemented with serum from BB-fed rats had enhanced viability after exposure to hydrogen peroxide. These findings suggest that BB supplementation may protect against neurodegeneration and cognitive impairment mediated by excitotoxicity and oxidative stress. JF - Neurobiology of aging AU - Duffy, Kara B AU - Spangler, Edward L AU - Devan, Bryan D AU - Guo, Zhihong AU - Bowker, Jonna L AU - Janas, Anne M AU - Hagepanos, Adrienne AU - Minor, Robin K AU - DeCabo, Rafael AU - Mouton, Peter R AU - Shukitt-Hale, Barbara AU - Joseph, James A AU - Ingram, Donald K AD - Laboratory of Experimental Gerontology, Intramural Research Program, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1680 EP - 1689 VL - 29 IS - 11 KW - Plant Extracts KW - 0 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Phytotherapy -- methods KW - Animals KW - Rats, Inbred F344 KW - Male KW - Fruit -- chemistry KW - Learning Disorders -- physiopathology KW - Oxidative Stress -- drug effects KW - Blueberry Plants -- chemistry KW - Learning -- drug effects KW - Dietary Supplements KW - Plant Extracts -- administration & dosage KW - Learning Disorders -- prevention & control KW - Learning Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69656854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+aging&rft.atitle=A+blueberry-enriched+diet+provides+cellular+protection+against+oxidative+stress+and+reduces+a+kainate-induced+learning+impairment+in+rats.&rft.au=Duffy%2C+Kara+B%3BSpangler%2C+Edward+L%3BDevan%2C+Bryan+D%3BGuo%2C+Zhihong%3BBowker%2C+Jonna+L%3BJanas%2C+Anne+M%3BHagepanos%2C+Adrienne%3BMinor%2C+Robin+K%3BDeCabo%2C+Rafael%3BMouton%2C+Peter+R%3BShukitt-Hale%2C+Barbara%3BJoseph%2C+James+A%3BIngram%2C+Donald+K&rft.aulast=Duffy&rft.aufirst=Kara&rft.date=2008-11-01&rft.volume=29&rft.issue=11&rft.spage=1680&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+aging&rft.issn=1558-1497&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-23 N1 - Date created - 2008-10-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials? AN - 69649769; 18632727 AB - Quantum dots (QDs) are being investigated as novel in vivo imaging agents. The leaching of toxic metals from these QDs in biological systems is of great concern. This study compared the cytotoxic mechanisms of two QD species made of different core materials (cadmium selenide [CdSe] vs. indium gallium phosphide [InGaP]) but similar core sizes (5.1 vs. 3.7 nm) and surface compositions (both ZnS capped, lipid-coated and pegylated). The CdSe QD was found to be 10-fold more toxic to porcine renal proximal tubule cells (LLC-PK1) than the InGaP QD on a molar basis, as determined by MTT assay (48 h IC(50) 10nM for CdSe vs. 100nM for InGaP). Neither of the QD species induced appreciable oxidative stress, as determined by lipid peroxide and reduced glutathione content, suggesting that toxicity was not metal associated. In agreement, treatment of cells with CdSe QDs was not associated with changes in metallothionein-IA (MT-IA) gene expression or Cd-associated caspase 3 enzyme activation. By contrast, incubation of the LLC-PK1 cells with the InGaP QD resulted in a dramatic increase in MT-IA expression by 21- and 43-fold, at 8 and 24 h, respectively. The most remarkable finding was evidence of extensive autophagy in QD-treated cells, as determined by Lysotracker Red dye uptake, TEM, and LC3 immunobloting. Autophagy induction has also been described for other nanomaterials and may represent a common cellular response. These data suggest that QD cytotoxicity is dependent upon properties of the particle as a whole, and not exclusively the metal core materials. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Stern, Stephan T AU - Zolnik, Banu S AU - McLeland, Christopher B AU - Clogston, Jeffery AU - Zheng, Jiwen AU - McNeil, Scott E AD - Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. sternstephan@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 140 EP - 152 VL - 106 IS - 1 KW - Cadmium Compounds KW - 0 KW - Phosphines KW - Selenium Compounds KW - gallium phosphide KW - 12063-98-8 KW - Metallothionein KW - 9038-94-2 KW - cadmium selenide KW - A7F646JC5C KW - Gallium KW - CH46OC8YV4 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Swine KW - Animals KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cell Shape -- drug effects KW - Oxidative Stress -- drug effects KW - LLC-PK1 Cells KW - Inhibitory Concentration 50 KW - Time Factors KW - Metallothionein -- metabolism KW - Caspase 3 -- metabolism KW - Selenium Compounds -- toxicity KW - Epithelial Cells -- ultrastructure KW - Autophagy -- drug effects KW - Quantum Dots KW - Epithelial Cells -- drug effects KW - Kidney -- drug effects KW - Cadmium Compounds -- toxicity KW - Gallium -- toxicity KW - Phosphines -- toxicity KW - Kidney -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69649769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Induction+of+autophagy+in+porcine+kidney+cells+by+quantum+dots%3A+a+common+cellular+response+to+nanomaterials%3F&rft.au=Stern%2C+Stephan+T%3BZolnik%2C+Banu+S%3BMcLeland%2C+Christopher+B%3BClogston%2C+Jeffery%3BZheng%2C+Jiwen%3BMcNeil%2C+Scott+E&rft.aulast=Stern&rft.aufirst=Stephan&rft.date=2008-11-01&rft.volume=106&rft.issue=1&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfn137 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-12-23 N1 - Date created - 2008-10-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2003 Mar 14;302(3):496-501 [12615061] Environ Sci Technol. 2005 Mar 1;39(5):1378-83 [15787380] Microbiol Immunol. 2004;48(9):669-75 [15383704] Cancer Res. 1988 Feb 1;48(3):589-601 [3335022] Biochem Pharmacol. 1990 Jun 1;39(11):1751-7 [2344372] Toxicol Appl Pharmacol. 1993 May;120(1):72-9 [8511784] Science. 1998 Sep 25;281(5385):2013-6 [9748157] Nano Lett. 2005 Feb;5(2):331-8 [15794621] J Mol Med (Berl). 2005 May;83(5):377-85 [15688234] Curr Med Chem. 2005;12(10):1161-208 [15892631] Kidney Blood Press Res. 2005;28(3):127-33 [15812196] Biochem Biophys Res Commun. 2005 Nov 11;337(1):52-60 [16185655] J Clin Invest. 2005 Oct;115(10):2679-88 [16200202] Bioconjug Chem. 2005 Nov-Dec;16(6):1488-94 [16287246] Chem Biol. 2005 Nov;12(11):1227-34 [16298302] Circ J. 2006 Jan;70(1):129-40 [16377937] Nano Lett. 2006 Apr;6(4):800-8 [16608287] Anal Bioanal Chem. 2006 May;385(1):105-13 [16547740] Toxicol Appl Pharmacol. 2006 May 1;212(3):212-23 [16169029] Am J Physiol Cell Physiol. 2006 Jun;290(6):C1495-502 [16407415] Autophagy. 2006 Jan-Mar;2(1):39-46 [16874071] Mol Aspects Med. 2006 Oct-Dec;27(5-6):411-25 [16973212] Curr Top Dev Biol. 2006;76:89-101 [17118264] Toxicol Lett. 2006 Dec 15;167(3):191-200 [17049762] Small. 2005 Jul;1(7):706-9 [17193510] J Invest Dermatol. 2007 Jan;127(1):143-53 [16902417] Nano Lett. 2006 Dec;6(12):2826-32 [17163713] Life Sci. 2007 Jan 23;80(7):650-8 [17125799] Langmuir. 2007 Feb 13;23(4):1974-80 [17279683] J Am Chem Soc. 2007 Mar 21;129(11):3333-8 [17319667] Bioconjug Chem. 2007 Mar-Apr;18(2):389-96 [17263568] Autophagy. 2007 May-Jun;3(3):278-81 [17351332] Toxicol In Vitro. 2007 Jun;21(4):677-84 [17383151] J Nanosci Nanotechnol. 2007 Feb;7(2):497-503 [17450785] Autophagy. 2007 Jul-Aug;3(4):371-3 [17438362] Eur J Pharmacol. 2007 Jul 30;568(1-3):89-98 [17560995] Cell Cycle. 2007 Aug 1;6(15):1837-49 [17671424] Nanomedicine (Lond). 2006 Aug;1(2):209-17 [17716110] Environ Health Perspect. 2007 Sep;115(9):1339-43 [17805425] Bioconjug Chem. 2007 Sep-Oct;18(5):1391-6 [17630789] Autophagy. 2007 Nov-Dec;3(6):542-5 [17611390] Sci Total Environ. 2008 Mar 15;392(1):50-8 [18166216] Aquat Toxicol. 2008 Feb 18;86(3):333-40 [18160110] Autophagy. 2007 May-Jun;3(3):181-206 [17224625] EMBO J. 2000 Nov 1;19(21):5720-8 [11060023] Toxicology. 2003 Feb 1;183(1-3):211-20 [12504352] J Pharmacol Exp Ther. 1998 Oct;287(1):344-51 [9765355] J Am Chem Soc. 2005 Mar 2;127(8):2496-504 [15725004] J Am Chem Soc. 2005 Mar 23;127(11):3870-8 [15771523] Biochem Biophys Res Commun. 2004 Jan 9;313(2):453-8 [14684184] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfn137 ER - TY - JOUR T1 - Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. AN - 66717577; 19430578 AB - Psychostimulant abuse is a serious social and health problem, for which no effective treatments currently exist. A number of review articles have described predominantly 'clinic'-based pharmacotherapies for the treatment of psychostimulant addiction, but none have yet been shown to be definitively effective for use in humans. In the present article, we review various 'hypothesis'- or 'mechanism'-based pharmacological agents that have been studied at the preclinical level and evaluate their potential use in the treatment of psychostimulant addiction in humans. These compounds target brain neurotransmitter or neuromodulator systems, including dopamine (DA), gamma-aminobutyric acid (GABA), endocannabinoid, glutamate, opioid and serotonin, which have been shown to be critically involved in drug reward and addiction. For drugs in each category, we first briefly review the role of each neurotransmitter system in psychostimulant actions, and then discuss the mechanistic rationale for each drug's potential anti-addiction efficacy, major findings with each drug in animal models of psychostimulant addiction, abuse liability and potential problems, and future research directions. We conclude that hypothesis-based medication development strategies could significantly promote medication discovery for the effective treatment of psychostimulant addiction. JF - Current drug abuse reviews AU - Xi, Zheng-Xiong AU - Gardner, Eliot L AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. zxi@intra.nida.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 303 EP - 327 VL - 1 IS - 3 KW - Cannabinoid Receptor Modulators KW - 0 KW - Central Nervous System Stimulants KW - Dopamine Agonists KW - Dopamine Antagonists KW - Excitatory Amino Acid Agonists KW - GABA Agonists KW - GABA Uptake Inhibitors KW - Narcotic Antagonists KW - Receptors, AMPA KW - Receptors, N-Methyl-D-Aspartate KW - Serotonin Antagonists KW - Serotonin Receptor Agonists KW - Vesicular Monoamine Transport Proteins KW - Glutamic Acid KW - 3KX376GY7L KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - endocannabinoids KW - dopamine KW - Psychostimulant KW - reward KW - reinstatement KW - GABA KW - addiction KW - glutamate KW - Animals KW - Dopamine Antagonists -- therapeutic use KW - Brain -- drug effects KW - GABA Agonists -- therapeutic use KW - Humans KW - Serotonin Antagonists -- adverse effects KW - Cocaine-Related Disorders -- rehabilitation KW - Cannabinoid Receptor Modulators -- metabolism KW - Treatment Outcome KW - gamma-Aminobutyric Acid -- metabolism KW - Excitatory Amino Acid Agonists -- adverse effects KW - Vesicular Monoamine Transport Proteins -- antagonists & inhibitors KW - GABA Agonists -- adverse effects KW - Serotonin Antagonists -- therapeutic use KW - Cocaine-Related Disorders -- diagnosis KW - Glutamic Acid -- metabolism KW - Excitatory Amino Acid Agonists -- therapeutic use KW - Cocaine-Related Disorders -- psychology KW - Dopamine Agonists -- adverse effects KW - Dopamine -- metabolism KW - Receptors, AMPA -- antagonists & inhibitors KW - Dopamine Agonists -- therapeutic use KW - Narcotic Antagonists -- adverse effects KW - Narcotic Antagonists -- therapeutic use KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Dopamine Antagonists -- adverse effects KW - Drug Evaluation, Preclinical KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66717577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+abuse+reviews&rft.atitle=Hypothesis-driven+medication+discovery+for+the+treatment+of+psychostimulant+addiction.&rft.au=Xi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2008-11-01&rft.volume=1&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Current+drug+abuse+reviews&rft.issn=1874-4745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-08-13 N1 - 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Biochem Behav. 2002 Apr;71(4):533-54 [11888546] Psychopharmacology (Berl). 2002 Mar;160(3):263-70 [11889495] Psychopharmacology (Berl). 2002 Apr;161(1):17-22 [11967626] Behav Pharmacol. 2002 Mar;13(2):105-15 [11981223] Pharmacol Rev. 2002 Jun;54(2):161-202 [12037135] Psychopharmacology (Berl). 2002 Jun;161(4):387-95 [12073166] J Psychopharmacol. 2002 Jun;16(2):139-43 [12095072] Eur J Neurosci. 2002 Jun;15(12):2016-26 [12099907] Pharmacol Biochem Behav. 2002 Sep;73(2):333-7 [12117587] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rethinking the Ethics of Vital Organ Donations AN - 58795428; 2008-242891 AB - Accepted medical practice already violates the dead donor rule. Explicitly jettisoning the rule- allowing vital organs to be extracted, under certain conditions, from living patients-is a radical change only at the conceptual level. But it would expand the pools of eligible organ donors. Adapted from the source document. JF - Hastings Center Report AU - Miller, Franklin G AU - Truog, Robert D AD - Department of Bioethics, National Institutes of Health Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 38 EP - 46 PB - Hastings Center, Garrison NY VL - 38 IS - 6 SN - 0093-0334, 0093-0334 KW - Health conditions and policy - Medicine and health care KW - Law and ethics - Ethics KW - Donation of organs, tissues, etc. KW - Ethics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58795428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hastings+Center+Report&rft.atitle=Rethinking+the+Ethics+of+Vital+Organ+Donations&rft.au=Miller%2C+Franklin+G%3BTruog%2C+Robert+D&rft.aulast=Miller&rft.aufirst=Franklin&rft.date=2008-11-01&rft.volume=38&rft.issue=6&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Hastings+Center+Report&rft.issn=00930334&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-28 N1 - CODEN - HSCRAS N1 - SubjectsTermNotLitGenreText - Donation of organs, tissues, etc.; Ethics ER - TY - JOUR T1 - Social and physical environments of sports and exercise reported among adults in the American Time Use Survey AN - 57306537; 200918489 AB - Objective Demographic and temporal patterns in the social and physical environments of sports and exercise in the American Time Use Survey (years 2003 -2006) are described. Method The sample consisted of adult respondents (ages 21+) reporting at least one bout of sports or exercise (N = 8844). During the interview, participants reported where (e.g., outdoors, home, work) and with whom (e.g., alone, family, coworkers) each bout occurred. Sample-weighted multinomial logistic regression analyses estimated the adjusted proportion of bouts occurring in each environment by gender, age, education, race/ethnicity, season, weekend/weekday, and time of day. Results Among members of the oldest age group (ages 60+), more exercise bouts occurred alone and outdoors compared to younger age groups. Among college graduates, more exercise bouts occurred at a gym/health club compared to groups with lower levels of education. Exercise bouts occurring alone were most likely to happen in the winter, on weekdays, and in the morning. Exercise bouts occurring outdoors were most likely to happen in the summer, on weekend days, and in the morning. Conclusion Future research and intervention efforts exploring where, when and with whom exercise bouts occur may prove beneficial to addressing public health concerns about physical inactivity. [Copyright Elsevier B.V.] JF - Preventive Medicine AU - Dunton, Genevieve Fridlund AU - Berrigan, David AU - Ballard-Barbash, Rachel AU - Graubard, Barry I AU - Atienza, Audie A AD - Health Promotion Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences National Cancer Institute, 6130 Executive Blvd/EPN 4051C, MSC 7365, Bethesda, MD 20892-7365, USA duntong@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 519 EP - 524 PB - Elsevier Ltd, The Netherlands VL - 47 IS - 5 SN - 0091-7435, 0091-7435 KW - Exercise Time Environment Social environment Age groups Education Seasons KW - Time use KW - Built environment KW - Social environment KW - Exercise KW - Sports KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57306537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preventive+Medicine&rft.atitle=Social+and+physical+environments+of+sports+and+exercise+reported+among+adults+in+the+American+Time+Use+Survey&rft.au=Dunton%2C+Genevieve+Fridlund%3BBerrigan%2C+David%3BBallard-Barbash%2C+Rachel%3BGraubard%2C+Barry+I%3BAtienza%2C+Audie+A&rft.aulast=Dunton&rft.aufirst=Genevieve&rft.date=2008-11-01&rft.volume=47&rft.issue=5&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Preventive+Medicine&rft.issn=00917435&rft_id=info:doi/10.1016%2Fj.ypmed.2008.07.001 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Exercise; Sports; Time use; Built environment; Public health; Social environment DO - http://dx.doi.org/10.1016/j.ypmed.2008.07.001 ER - TY - JOUR T1 - Social and Ethical Implications of Genomics, Race, Ethnicity, and Health Inequities AN - 57289380; 200913821 AB - Objectives To review ethical, ethnic/ancestral, and societal issues of genetic and genomic information and technologies in the context of racial and ethnic health disparities. Data Sources Research and journal articles, government reports, web sites. Conclusion As knowledge of human genetic variation and its link to diseases continues to grow, some see race and ethnicity well poised to serve as genetic surrogates in predicting disease etiology and treatment response. However, stereotyping and bias in clinical interactions can be barriers to effective treatment for racial and ethnic minority patients. Implications for Nursing Practice The nursing profession has a key role in assuring that genomic health care does not enhance racial and ethnic health inequities. This will require utilization of new genomic knowledge and caring for each patient as an individual in a culturally and clinically appropriate manner. [Copyright Elsevier B.V.] JF - Seminars in Oncology Nursing AU - Bonham, Vence L AU - Knerr, Sarah Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 254 EP - 261 PB - Elsevier Ltd, The Netherlands VL - 24 IS - 4 SN - 0749-2081, 0749-2081 KW - Human genetics clinical decision-making race health disparities KW - Racial differences KW - Health inequalities KW - Ethnicity KW - Nursing KW - Race KW - Aetiology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57289380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Oncology+Nursing&rft.atitle=Social+and+Ethical+Implications+of+Genomics%2C+Race%2C+Ethnicity%2C+and+Health+Inequities&rft.au=Bonham%2C+Vence+L%3BKnerr%2C+Sarah&rft.aulast=Bonham&rft.aufirst=Vence&rft.date=2008-11-01&rft.volume=24&rft.issue=4&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Oncology+Nursing&rft.issn=07492081&rft_id=info:doi/10.1016%2Fj.soncn.2008.08.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health inequalities; Racial differences; Race; Nursing; Ethnicity; Aetiology DO - http://dx.doi.org/10.1016/j.soncn.2008.08.005 ER - TY - JOUR T1 - Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin AN - 57287108; 200910469 AB - Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831-838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Schirmbeck, Frederike AU - Georgi, Alexander AU - Strohmaier, Jana AU - Schmael, Christine AU - Boesshenz, Katja V AU - Muhleisen, Thomas W AU - Herms, Stefan AU - Hoffmann, Per AU - Jamra, Rami Abou AU - Schumacher, Johannes AU - Maier, Wolfgang AU - Propping, Peter AU - Nothen, Markus M AU - Cichon, Sven AU - Rietschel, Marcella AU - Schulze, Thomas G AD - Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1977 EP - 1981 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 10 SN - 0162-3257, 0162-3257 KW - Schizophrenia KW - Genetics KW - Premorbid KW - Vulnerability KW - Phenotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57287108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Brief+Report%3A+No+Association+Between+Premorbid+Adjustment+in+Adult-Onset+Schizophrenia+and+Genetic+Variation+in+Dysbindin&rft.au=Schirmbeck%2C+Frederike%3BGeorgi%2C+Alexander%3BStrohmaier%2C+Jana%3BSchmael%2C+Christine%3BBoesshenz%2C+Katja+V%3BMuhleisen%2C+Thomas+W%3BHerms%2C+Stefan%3BHoffmann%2C+Per%3BJamra%2C+Rami+Abou%3BSchumacher%2C+Johannes%3BMaier%2C+Wolfgang%3BPropping%2C+Peter%3BNothen%2C+Markus+M%3BCichon%2C+Sven%3BRietschel%2C+Marcella%3BSchulze%2C+Thomas+G&rft.aulast=Schirmbeck&rft.aufirst=Frederike&rft.date=2008-11-01&rft.volume=38&rft.issue=10&rft.spage=1977&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-008-0582-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Premorbid; Schizophrenia; Phenotypes; Vulnerability; Genetics DO - http://dx.doi.org/10.1007/s10803-008-0582-6 ER - TY - JOUR T1 - Three-Year Changes in Adult Risk Drinking Behavior in Relation to the Course of Alcohol-Use Disorders AN - 57281598; 200901396 AB - Objective: This study examines the associations between the course of alcohol-use disorder (AUD) and changes in average daily volume of ethanol intake, frequency of risk drinking, and maximum quantity of drinks consumed per day over a 3-year follow-up interval in a sample of U.S. adults. Method: Data were taken from a longitudinal study of a nationally representative sample of U.S. adults, who were 18 years of age and older (mean age = 46.4) when initially interviewed in 2001-2002 and successfully reinterviewed approximately 3 years later (n = 22,245 baseline drinkers). The time reference period for the drinking measures was the 12 months preceding the interview. Changes in consumption reflect differences between Wave 1 and Wave 2 measures for individuals with nonmissing values at both Waves (n = 22,003 for volume of intake, 22,132 for frequency of risk drinking and 21,942 for maximum quantity of drinks). Results: There were positive changes in all consumption measures associated with developing an AUD and negative changes associated with remission of an AUD, even among individuals who continued to drink. Increases and decreases associated with onset and offset of dependence exceeded those associated with onset/offset of abuse only, and the decreases associated with full remission from dependence exceeded those associated with partial remission. There were few changes in consumption among individuals whose AUD status did not change. Interactions of AUD transitions with other factors indicate that development of an AUD is associated with a greater increase in consumption among men, possibly reflecting their greater total body water and lower blood alcohol concentration in response to a given dose of ethanol, and among individuals with high baseline levels of consumption. Conclusions: Changes in consumption associated with onset and offset of AUD are substantial enough to have important implications for the risk of associated physical and psychological harm. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Chou, Patricia AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Room 3071, MSC 9304, Bethesda, Maryland 20892-9304 ddawson@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 866 EP - 877 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 69 IS - 6 SN - 1937-1888, 1937-1888 KW - Alcohol consumption KW - Remission KW - Problem drinking KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57281598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=Three-Year+Changes+in+Adult+Risk+Drinking+Behavior+in+Relation+to+the+Course+of+Alcohol-Use+Disorders&rft.au=Dawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BChou%2C+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2008-11-01&rft.volume=69&rft.issue=6&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Alcohol related disorders; Alcohol consumption; Remission; Problem drinking ER - TY - JOUR T1 - Signal-Averaged Electrocardiogram in Physically Healthy, Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Users AN - 57277808; 200903991 AB - Objectives: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) use has been associated with cardiac arrhythmias. Markers of ventricular late potentials (VLP), which may be a precursor to malignant ventricular arrhythmias, can be detected by signal-averaged electrocardiography (SA-ECG), but not by standard ECG. Methods: We evaluated SA-ECG parameters in 21 physically healthy, recently abstinent MDMA users who also used cannabis (11 males, mean [SD] age 23.3 [4.6] years, 2.8 [2.0] years of use), 18 physically healthy cannabis users (8 males, mean [SD] age 26.6 [7.1] years, 11.2 [5.4] years of use) and 54 non-drug-using controls (21 males, mean [SD] age 28.4 [7.8] years). We analyzed three SA-ECG parameters considered markers of VLPs: duration of filtered QRS complex (fQRS), duration of low amplitude potentials during terminal 40 ms of QRS complex (LAS40), and root mean square voltage during terminal 40 ms of QRS complex (RMS40). Results: MDMA users, cannabis users, and non-drug-using controls did not differ significantly from each other in fQRS, LAS40, or RMS40 values or in the proportion of subjects with abnormal SA-ECG parameters. There were significant gender differences among controls, but not among MDMA users. Conclusion: These findings suggest that chronic MDMA use is neither quantitatively nor qualitatively associated with a high prevalence of abnormal SA-ECG parameters indicative of VLP markers. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Kanneganti, Praveen AU - Huestis, Marilyn A AU - Kolbrich, Erin A AU - Goodwin, Robert AU - Ziegelstein, Roy C AU - Gorelick, David A AD - Intramural Research Program, Department of Health and Human Services, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 712 EP - 720 PB - Taylor & Francis Inc., Philadelphia, PA VL - 34 IS - 6 SN - 0095-2990, 0095-2990 KW - Heart arrhythmia KW - Ecstasy drug KW - Echocardiography KW - Cannabis KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57277808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Signal-Averaged+Electrocardiogram+in+Physically+Healthy%2C+Chronic+3%2C4-Methylenedioxymethamphetamine+%28MDMA%29+Users&rft.au=Kanneganti%2C+Praveen%3BHuestis%2C+Marilyn+A%3BKolbrich%2C+Erin+A%3BGoodwin%2C+Robert%3BZiegelstein%2C+Roy+C%3BGorelick%2C+David+A&rft.aulast=Kanneganti&rft.aufirst=Praveen&rft.date=2008-11-01&rft.volume=34&rft.issue=6&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.1080%2F00952990802308254 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-03-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Ecstasy drug; Cannabis; Echocardiography; Heart arrhythmia DO - http://dx.doi.org/10.1080/00952990802308254 ER - TY - JOUR T1 - End-of-life care in Italy: personal experience of family caregivers. A content analysis of open questions from the Italian Survey of the Dying of Cancer (ISDOC) AN - 57274600; 200902165 AB - Objective: This study aims at describing the emotional and practical experience of a representative sample of Italian non-professional caregivers when caring for a terminally ill family member and is part of the Italian Survey of the Dying of Cancer, which involved 2000 adult cancer deaths representative of the whole country. Methods: Information on patients' experience was gathered from non-professional caregivers by an interview. A specific question was asked about the caregivers' emotional and practical experiences while assisting a terminally ill relative. A content analysis of the open question on caregivers' perceptions was performed on transcribed answers. Three researchers independently generated categories. Subsequently, areas where they differed were reconsidered and an interpretation was agreed upon. Results: Valid interviews were obtained from 1231 non-professional caregivers. Answers were classified according to the perception of the experience as positive (33.1%), negative (65.1%) or neutral (1.8%). Conclusion: Assisting a family member with cancer in his/her last three months of life is a very strong physical and mental stress for the caregiver. In some cases, this experience is nevertheless perceived as an evolution chance. Health-care providers should need to develop programs to ensure that family caregivers' needs for information and support are given great importance. [Copyright 2008 John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Morasso, Gabriella AU - Costantini, Massimo AU - Di Leo, Silvia AU - Roma, Serena AU - Miccinesi, Guido AU - Merlo, Domenico Franco AU - Beccaro, Monica AD - Unit of Psycho-Oncology, National Cancer Institute, Genoa, Italy gabriella.morasso@istge.it Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1073 EP - 1080 PB - John Wiley, Chichester UK VL - 17 IS - 11 SN - 1057-9249, 1057-9249 KW - Families KW - Bereavement KW - Italy KW - Cancer KW - Terminally ill people KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57274600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=End-of-life+care+in+Italy%3A+personal+experience+of+family+caregivers.+A+content+analysis+of+open+questions+from+the+Italian+Survey+of+the+Dying+of+Cancer+%28ISDOC%29&rft.au=Morasso%2C+Gabriella%3BCostantini%2C+Massimo%3BDi+Leo%2C+Silvia%3BRoma%2C+Serena%3BMiccinesi%2C+Guido%3BMerlo%2C+Domenico+Franco%3BBeccaro%2C+Monica&rft.aulast=Morasso&rft.aufirst=Gabriella&rft.date=2008-11-01&rft.volume=17&rft.issue=11&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1332 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Carers; Families; Cancer; Terminally ill people; Italy; Bereavement DO - http://dx.doi.org/10.1002/pon.1332 ER - TY - JOUR T1 - Anticipated Affective Consequences of Physical Activity Adoption and Maintenance AN - 57273054; 200901465 AB - Objective: The expected emotional consequences of future actions are thought to play an important role in health behavior change. This research examined whether anticipated affective consequences of success and failure vary across stages of physical activity change and differentially predict physical activity adoption as compared to maintenance. Design: Using a prospective design over a 3-smonth period, a community sample of 329 healthy, middle-aged adults were assessed at 2 time points. Main Outcome Measures: Anticipated positive and negative emotions, stage of behavior change (precontemplation [PC], contemplation [C], preparation [P], action [A], maintenance [M]), and level of physical activity. Results: At baseline, anticipated positive emotions were greater in C versus PC, whereas anticipated negative emotions were greater in M versus A and in M versus P. Higher anticipated positive but not negative emotions predicted physical activity adoption and maintenance after 3 months. Conclusion: Although the expected affective consequences of future success and failure differentiated among individuals in the early and later stages of physical activity change, respectively; only the anticipated affective consequences of success predicted future behavior. [Copyright 2008 The American Psychological Association.] JF - Health Psychology AU - Dunton, Genevieve Fridlund AU - Vaughan, Elaine AD - Cancer Prevention Fellow, Health Promotion Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard, EPN Rm 4051C MSC 7355, Bethesda, MD 20892-7365 duntong@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 703 EP - 710 PB - American Psychological Association, Washington DC VL - 27 IS - 6 SN - 0278-6133, 0278-6133 KW - anticipated emotions, stages of change, health behavior, physical activity KW - Negative emotions KW - Physical activity KW - Behavioural changes KW - Stages of change KW - Positive affect KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57273054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Anticipated+Affective+Consequences+of+Physical+Activity+Adoption+and+Maintenance&rft.au=Dunton%2C+Genevieve+Fridlund%3BVaughan%2C+Elaine&rft.aulast=Dunton&rft.aufirst=Genevieve&rft.date=2008-11-01&rft.volume=27&rft.issue=6&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2F0278-6133.27.6.703 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-02-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Physical activity; Negative emotions; Health behaviour; Behavioural changes; Stages of change; Positive affect DO - http://dx.doi.org/10.1037/0278-6133.27.6.703 ER - TY - JOUR T1 - Functional Magnetic Resonance Imaging and Pediatric Anxiety AN - 57262890; 200900746 AB - Proceeding in four steps, this review uses research on pediatric anxiety disorders to illustrate how functional magnetic resonance imaging (fMRI) studies may inform therapeutics. First, we describe how; in developmental psychopathology generally, basic and clinical fMRI research guide each other. Second, we discuss how investigators probe specific behaviors associated with anxiety. Here, we focus on one core feature of anxiety, the abnormal modulation of attention. Pictures of angry faces and other threatening stimuli capture attention to a greater degree in anxious than nonanxious patients; in this way, such stimuli interact with and influence a cognitive process called "attention orienting." Using threatening stimuli to manipulate the focus of attention, fMRI studies may eventually test whether interventions such as cognitive behavioral therapy (CBT) reduce anxiety by altering the abnormal orienting of attention. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Pine, Daniel S AU - Guyer, Amanda E AU - Leibenluft, Ellen AD - National Institute of Mental Health, Mood and Anxiety Program, Building 15K, Room 203, 15K North Drive, MSC 2670, Bethesda, MD 20892 pined@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 1217 EP - 1221 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 47 IS - 11 SN - 0890-8567, 0890-8567 KW - Paediatrics KW - Anxiety KW - Magnetic resonance imaging KW - Psychopathology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57262890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Functional+Magnetic+Resonance+Imaging+and+Pediatric+Anxiety&rft.au=Pine%2C+Daniel+S%3BGuyer%2C+Amanda+E%3BLeibenluft%2C+Ellen&rft.aulast=Pine&rft.aufirst=Daniel&rft.date=2008-11-01&rft.volume=47&rft.issue=11&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2FCHI.0b013e318185dad0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-01-08 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Paediatrics; Anxiety; Psychopathology DO - http://dx.doi.org/10.1097/CHI.0b013e318185dad0 ER - TY - JOUR T1 - Interpreting GLOBE Societal Practices Scales AN - 57253914; 200823825 AB - Some of the Global Leadership and Organizational Behavior Effectiveness (GLOBE) Societal Practices scales ask for descriptions of typical personality traits that might be interpreted as judgments of national character. Ratings of national character reflect cultural identities and social dynamics, but previous research suggests that they are unrelated to the mean personality traits of the culture's members. Analyses at the culture level comparing GLOBE scales with aggregate assessed personality traits (n = 34) and with measures of perceived national character (n = 33) showed that these GLOBE scales are better construed as unfounded stereotypes than as actual depictions of the society members' personality traits. [Reprinted by permission of Sage Publications Inc., copyright 2008.] JF - Journal of Cross-Cultural Psychology AU - McCrae, Robert R AU - Terracciano, Antonio AU - Realo, Anu AU - Allik, Juri AD - National Institute on Aging, NIH mccraej@grc.nia.nih.gov Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 805 EP - 810 PB - Sage Publications, Thousand Oaks VL - 39 IS - 6 SN - 0022-0221, 0022-0221 KW - personality traits KW - national character KW - cultural identity KW - stereotypes KW - GLOBE scales KW - Scales KW - Personality KW - Cultural identity KW - Organizational behaviour KW - Nationalism KW - Stereotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Psychology&rft.atitle=Interpreting+GLOBE+Societal+Practices+Scales&rft.au=McCrae%2C+Robert+R%3BTerracciano%2C+Antonio%3BRealo%2C+Anu%3BAllik%2C+Juri&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2008-11-01&rft.volume=39&rft.issue=6&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Psychology&rft.issn=00220221&rft_id=info:doi/10.1177%2F0022022108323806 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPGB5 N1 - SubjectsTermNotLitGenreText - Personality; Organizational behaviour; Cultural identity; Stereotypes; Scales; Nationalism DO - http://dx.doi.org/10.1177/0022022108323806 ER - TY - JOUR T1 - A 1,100-year palaeoenvironmental record inferred from stable isotope and trace element compositions of ostracode and plant caryopses in sediments of Cattle Pond, Dongdao Island, South China Sea AN - 50521916; 2009-022589 JF - Journal of Paleolimnology AU - Liu, Xiaodong AU - Sun, Liguang AU - Wei, Gangjian AU - Wang, Yuhong AU - Yan, Hong AU - Liu, Kexin AU - Wu, Xiaohong Y1 - 2008/11// PY - 2008 DA - November 2008 SP - 987 EP - 1002 PB - Springer, Dordrecht VL - 40 IS - 4 SN - 0921-2728, 0921-2728 KW - calcium KW - magnesium KW - Far East KW - oxygen KW - isotopes KW - Xisha Islands KW - Ostracoda KW - Holocene KW - stable isotopes KW - cores KW - West Pacific KW - Cenozoic KW - radioactive isotopes KW - Dongdao Island KW - carbon KW - sediments KW - absolute age KW - Invertebrata KW - Northwest Pacific KW - Asia KW - chemical ratios KW - South China Sea KW - China KW - alkaline earth metals KW - Plantae KW - Quaternary KW - assemblages KW - isotope ratios KW - Crustacea KW - C-13/C-12 KW - O-18/O-16 KW - Mg/Ca KW - paleoenvironment KW - Arthropoda KW - North Pacific KW - metals KW - Mandibulata KW - Pacific Ocean KW - lacustrine environment KW - Cattle Pond KW - C-14 KW - upper Holocene KW - microfossils KW - lake sediments KW - 24:Quaternary geology KW - 03:Geochronology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50521916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Paleolimnology&rft.atitle=A+1%2C100-year+palaeoenvironmental+record+inferred+from+stable+isotope+and+trace+element+compositions+of+ostracode+and+plant+caryopses+in+sediments+of+Cattle+Pond%2C+Dongdao+Island%2C+South+China+Sea&rft.au=Liu%2C+Xiaodong%3BSun%2C+Liguang%3BWei%2C+Gangjian%3BWang%2C+Yuhong%3BYan%2C+Hong%3BLiu%2C+Kexin%3BWu%2C+Xiaohong&rft.aulast=Liu&rft.aufirst=Xiaodong&rft.date=2008-11-01&rft.volume=40&rft.issue=4&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Journal+of+Paleolimnology&rft.issn=09212728&rft_id=info:doi/10.1007%2Fs10933-008-9211-9 L2 - http://www.springerlink.com/(i42ivkufd5oczp45mspwbbyb)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100294,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 66 N1 - Document feature - illus. incl. 1 table, sect., strat. cols., geol. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absolute age; alkaline earth metals; Arthropoda; Asia; assemblages; C-13/C-12; C-14; calcium; carbon; Cattle Pond; Cenozoic; chemical ratios; China; cores; Crustacea; Dongdao Island; Far East; Holocene; Invertebrata; isotope ratios; isotopes; lacustrine environment; lake sediments; magnesium; Mandibulata; metals; Mg/Ca; microfossils; North Pacific; Northwest Pacific; O-18/O-16; Ostracoda; oxygen; Pacific Ocean; paleoenvironment; Plantae; Quaternary; radioactive isotopes; sediments; South China Sea; stable isotopes; upper Holocene; West Pacific; Xisha Islands DO - http://dx.doi.org/10.1007/s10933-008-9211-9 ER - TY - JOUR T1 - Testing different types of genotype-environment correlation: an extended children-of-twins model AN - 37029342; 3805397 AB - This study presents an extended children-of-twins model, which allowed the authors to test the direction of the association between parenting and child adjustment. Three mechanisms were examined: direct phenotypic influence of parenting on child behavior (controlling for both parental and child genotype), passive genotype-environment correlation, and evocative genotype-environment correlation. This model was tested with Monte Carlo simulations. The authors generated data sets consisting of 1,000 twin parent pairs together with their children and 1,000 twin children pairs together with their parents. These simulated data sets were then used to estimate the model, and the procedure was repeated 1,000 times. The simulation results showed that this model recovered the true values of parameters with high precision. The model was also applied to an observed data set to analyze, as a first example, the association between maternal emotional overinvolvement and child internalizing problems. The results showed that this association was best explained by evocative genotype-environment correlation. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Narusyte, Jurgita AU - Neiderhiser, Jenae M AU - D' Onofrio, Brian M AU - Reiss, David AU - Spotts, Erica L AU - Ganiban, Jody AU - Lichtenstein, Paul AD - Karolinska Institute ; Pennsylvania State University ; Indiana University ; Yale University ; National Institute on Aging ; George Washington University Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1591 EP - 1603 VL - 44 IS - 6 SN - 0012-1649, 0012-1649 KW - Economics KW - Sociology KW - Genotype KW - Monte Carlo simulation KW - Social psychology KW - Twins KW - Psychology KW - Parents KW - Children KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37029342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=Testing+different+types+of+genotype-environment+correlation%3A+an+extended+children-of-twins+model&rft.au=Narusyte%2C+Jurgita%3BNeiderhiser%2C+Jenae+M%3BD%27+Onofrio%2C+Brian+M%3BReiss%2C+David%3BSpotts%2C+Erica+L%3BGaniban%2C+Jody%3BLichtenstein%2C+Paul&rft.aulast=Narusyte&rft.aufirst=Jurgita&rft.date=2008-11-01&rft.volume=44&rft.issue=6&rft.spage=1591&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2Fa0013911 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 2212; 9184; 13030 11646 4777 6093; 8268 12265 3865 4025 10214 12224 971 12228 10919; 11901 10404; 10404 DO - http://dx.doi.org/10.1037/a0013911 ER - TY - JOUR T1 - Identification and Characterization of the Plasmodium yoelii PyP140/RON4 Protein, an Orthologue of Toxoplasma gondii RON4, Whose Cysteine-Rich Domain Does Not Protect against Lethal Parasite Challenge Infection AN - 21502641; 12495300 AB - Previously, we identified a Plasmodium yoelii YM 140-kDa merozoite protein, designated PyP140, which formed a complex with apical membrane antigen 1 (AMA1). Furthermore, we produced a nonprotective monoclonal antibody (MAb), 48F8, that immunoprecipitated metabolically labeled PyP140 and localized the protein to the merozoite's apical end and, less frequently, to the merozoite surface, as observed by immunofluorescence assay (IFA). Here, using MAb 48F8, we have identified the pyp140 gene by screening a P. yoelii -Zap cDNA expression library. The pyp140 cDNA covers approximately 90% of the putative open reading frame (ORF) of PY02159 from the P. yoelii NL genome sequencing project. Analysis of the complete gene identified the presence of two introns. The ORF encodes a 102,407-Da protein with an amino-terminal signal sequence, a series of three unique types of repeats, and a cysteine-rich region. The binding site of MAb 48F8 was also identified. A BLAST search with the deduced amino acid sequence shows significant similarity with the Toxoplasma gondii RON4 protein and the Plasmodium falciparum RON4 protein, and the sequence is highly conserved in other Plasmodium species. We produced the cysteine-rich domain of PyP140/RON4 by using the Pichia pastoris expression system and characterized the recombinant protein biochemically and biophysically. BALB/c mice immunized with the protein formulated in oil-in-water adjuvants produced antibodies that recognize parasitized erythrocytes by IFA and native PyP140/RON4 by immunoblotting but failed to protect against a lethal P. yoelii YM infection. Our results show that PyP140/RON4 is located within the rhoptries or micronemes. It may associate in part with AMA1, but the conserved cysteine-rich domain does not appear to elicit inhibitory antibodies, a finding that is supported by the marked sequence conservation in this protein within Plasmodium spp., suggesting that it is not under immune pressure. JF - Infection and Immunity AU - Narum, David L AU - Nguyen, Vu AU - Zhang, Yanling AU - Glen, Jacqueline AU - Shimp, Richard L AU - Lambert, Lynn AU - Ling, Irene T AU - Reiter, Karine AU - Ogun, Solabomi A AU - Long, Carole AU - Holder, Anthony A AU - Herrera, Raul AD - Malaria Vaccine Development Branch, NIH, Rockville, Maryland 20852, dnarum@niaid.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 4876 EP - 4882 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Genomes KW - Apical membrane antigen 1 KW - Parasites KW - Erythrocytes KW - Adjuvants KW - Infection KW - Conserved sequence KW - Plasmodium yoelii KW - Pressure KW - Immunoblotting KW - Monoclonal antibodies KW - Plasmodium falciparum KW - Immunofluorescence KW - Immunity KW - Micronemes KW - Toxoplasma gondii KW - Introns KW - DNA KW - Proteins KW - Merozoites KW - Pichia pastoris KW - Open reading frames KW - Amino acid sequence KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21502641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+and+Characterization+of+the+Plasmodium+yoelii+PyP140%2FRON4+Protein%2C+an+Orthologue+of+Toxoplasma+gondii+RON4%2C+Whose+Cysteine-Rich+Domain+Does+Not+Protect+against+Lethal+Parasite+Challenge+Infection&rft.au=Narum%2C+David+L%3BNguyen%2C+Vu%3BZhang%2C+Yanling%3BGlen%2C+Jacqueline%3BShimp%2C+Richard+L%3BLambert%2C+Lynn%3BLing%2C+Irene+T%3BReiter%2C+Karine%3BOgun%2C+Solabomi+A%3BLong%2C+Carole%3BHolder%2C+Anthony+A%3BHerrera%2C+Raul&rft.aulast=Narum&rft.aufirst=David&rft.date=2008-11-01&rft.volume=76&rft.issue=11&rft.spage=4876&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01717-07 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Parasites; Monoclonal antibodies; Erythrocytes; DNA; Proteins; Immunity; Immunofluorescence; Amino acid sequence; Apical membrane antigen 1; Genomes; Immunoblotting; Adjuvants; Infection; Micronemes; Introns; Conserved sequence; Merozoites; Pressure; Open reading frames; Toxoplasma gondii; Plasmodium yoelii; Plasmodium falciparum; Pichia pastoris DO - http://dx.doi.org/10.1128/IAI.01717-07 ER - TY - JOUR T1 - Outer Surface Protein A Protects Lyme Disease Spirochetes from Acquired Host Immunity in the Tick Vector AN - 21495909; 12495243 AB - The Lyme disease spirochete Borrelia burgdorferi alters the expression of outer surface protein (osp) genes as the bacterium cycles between ticks and mammals. OspA is produced as borreliae enter the tick vector and remains a major surface antigen during midgut colonization. To elucidate the role of OspA in the vector, we created an insertional deletion of ospA in strain B31-A3. The ospA mutant infects mice when it is injected intradermally and is acquired by larval ticks fed on these mice, where it persists through the molt to the nymph stage. Bacterial survival rates in artificially infected tick larvae fed on naive mice were compared with those in the vector fed on immune mice. The ospA mutant proliferates in larvae if it is exposed to blood from naive mice, but it declines in density after larval feeding if the blood is from immune mice. When uninfected larvae are fed on B-cell-deficient mice infected with the ospA mutant, larvae show borrelial densities and persistence that are significantly greater than those fed on infected, immunocompetent mice. We conclude that OspA serves a critical antibody-shielding role during vector blood meal uptake from immune hosts and is not required for persistence in the tick vector. JF - Infection and Immunity AU - Battisti, James M AU - Bono, James L AU - Rosa, Patricia A AU - Schrumpf, Merry E AU - Schwan, Tom G AU - Policastro, Paul F AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, ppolicastro@niaid.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 5228 EP - 5237 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Feeding KW - Borrelia burgdorferi KW - outer surface proteins KW - Ixodidae KW - Larvae KW - Survival KW - Immunity KW - Blood meals KW - Molting KW - OspA protein KW - Colonization KW - Spirochetes KW - Blood KW - outer surface protein A KW - surface antigens KW - Midgut KW - Lyme disease KW - J 02410:Animal Diseases KW - A 01490:Miscellaneous KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21495909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Outer+Surface+Protein+A+Protects+Lyme+Disease+Spirochetes+from+Acquired+Host+Immunity+in+the+Tick+Vector&rft.au=Battisti%2C+James+M%3BBono%2C+James+L%3BRosa%2C+Patricia+A%3BSchrumpf%2C+Merry+E%3BSchwan%2C+Tom+G%3BPolicastro%2C+Paul+F&rft.aulast=Battisti&rft.aufirst=James&rft.date=2008-11-01&rft.volume=76&rft.issue=11&rft.spage=5228&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00410-08 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Feeding; outer surface proteins; Larvae; Survival; Blood meals; Immunity; Molting; OspA protein; Blood; Spirochetes; Colonization; outer surface protein A; surface antigens; Midgut; Lyme disease; Borrelia burgdorferi; Ixodidae DO - http://dx.doi.org/10.1128/IAI.00410-08 ER - TY - JOUR T1 - Once is not enough: clinical trials in sepsis AN - 21117462; 8827905 JF - Intensive Care Medicine AU - Sweeney, Daniel A AU - Danner, Robert L AU - Eichacker, Peter Q AU - Natanson, Charles AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 2C145, Bethesda, MD, 20892-1662, USA, sweeneyda@cc.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1955 EP - 1960 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 VL - 34 IS - 11 SN - 0342-4642, 0342-4642 KW - Microbiology Abstracts B: Bacteriology KW - Sepsis KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21117462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intensive+Care+Medicine&rft.atitle=Once+is+not+enough%3A+clinical+trials+in+sepsis&rft.au=Sweeney%2C+Daniel+A%3BDanner%2C+Robert+L%3BEichacker%2C+Peter+Q%3BNatanson%2C+Charles&rft.aulast=Sweeney&rft.aufirst=Daniel&rft.date=2008-11-01&rft.volume=34&rft.issue=11&rft.spage=1955&rft.isbn=&rft.btitle=&rft.title=Intensive+Care+Medicine&rft.issn=03424642&rft_id=info:doi/10.1007%2Fs00134-008-1274-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Sepsis; Clinical trials DO - http://dx.doi.org/10.1007/s00134-008-1274-6 ER - TY - JOUR T1 - Saccharide/protein conjugate vaccines for Bordetella species: Preparation of saccharide, development of new conjugation procedures, and physico-chemical and immunological characterization of the conjugates AN - 21063357; 8607716 AB - Bordetellae are Gram-negative bacilli causing respiratory tract infections of mammals and birds. Clinically important are B. pertussis, B. parapertussis and B. bronchiseptica. B. pertussis vaccines have been successful in preventing pertussis in infants and children. Veterinary vaccines against B. bronchiseptica are available, but their efficacy and mode of action are not established. There is no vaccine against B. parapertussis. Based on the concept that immunity to non-capsulated Gram-negative bacteria may be conferred by serum IgG anti-LPS we studied chemical, serological and immunological properties of the O-specific polysaccharides (O-SP) of B. bronchiseptica and B. parapertussis obtained by different degradation procedures. One type of the B. parapertussis and two types of B. bronchiseptica O-SP were recognized based on the structure of their non-reducing end saccharide; no cross- reaction between the two B. bronchiseptica types was observed. Competitive inhibition assays showed the immunodominance of the non-reducing end of these O-SP. Conjugates of B. bronchiseptica and B. parapertussis O-SP were prepared by two methods: using the anhydro-Kdo residue exposed by mild acid hydrolysis of the LPS or the 2,5-anhydromannose residue exposed by deamination of the core glucosamine of the LPS, for binding to an aminooxylated protein. Both coupling methods were carried out at a neutral pH, room temperature, and in a short time. All conjugates, injected as saline solutions at a fraction of an estimated human dose, induced antibodies in mice to the homologous O-SP. These methodologies can be applied to prepare O-SP-based vaccines against other Gram-negative bacteria. JF - Vaccine AU - Kubler-Kielb, Joanna AU - Vinogradov, Evgeny AU - Ben-Menachem, Gil AU - Pozsgay, Vince AU - Robbins, John B AU - Schneerson, Rachel AD - National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA, kielbj@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 3587 EP - 3593 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 48 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bordetella KW - LPS KW - Vaccine KW - Conjugate KW - Temperature effects KW - Pertussis KW - Conjugation KW - Glucosamine KW - Deamination KW - Immunity KW - Children KW - Infection KW - Polysaccharides KW - Coupling methods KW - Hydrolysis KW - Respiratory tract diseases KW - Gram-negative bacilli KW - Gram-negative bacteria KW - Immunoglobulin G KW - Lipopolysaccharides KW - Vaccines KW - pH effects KW - Immunodominance KW - Infants KW - F 06905:Vaccines KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21063357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Saccharide%2Fprotein+conjugate+vaccines+for+Bordetella+species%3A+Preparation+of+saccharide%2C+development+of+new+conjugation+procedures%2C+and+physico-chemical+and+immunological+characterization+of+the+conjugates&rft.au=Kubler-Kielb%2C+Joanna%3BVinogradov%2C+Evgeny%3BBen-Menachem%2C+Gil%3BPozsgay%2C+Vince%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Kubler-Kielb&rft.aufirst=Joanna&rft.date=2008-11-01&rft.volume=26&rft.issue=48&rft.spage=3587&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.04.079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Pertussis; Conjugation; Glucosamine; Deamination; Immunity; Polysaccharides; Infection; Children; Hydrolysis; Coupling methods; Respiratory tract diseases; Gram-negative bacilli; Gram-negative bacteria; Immunoglobulin G; Lipopolysaccharides; Vaccines; pH effects; Infants; Immunodominance; Bordetella DO - http://dx.doi.org/10.1016/j.vaccine.2008.04.079 ER - TY - JOUR T1 - Chronic NMDA Administration Increases Neuroinflammatory Markers in Rat Frontal Cortex: Cross-Talk Between Excitotoxicity and Neuroinflammation AN - 21062857; 8597461 AB - Chronic N-Methyl-d-aspartate (NMDA) administration, a model of excitotoxicity, and chronic intracerebroventricular lipopolysaccharide infusion, a model of neuroinflammation, are reported to upregulate arachidonic acid incorporation and turnover in rat brain phospholipids as well as enzymes involved in arachidonic acid metabolism. This suggests cross-talk between signaling pathways of excitotoxicity and of neuroinflammation, involving arachidonic acid. To test whether chronic NMDA administrations to rats can upregulate brain markers of neuroinflammation, NMDA (25 mg/kg i.p.) or vehicle (1 ml saline/kg i.p.) was administered daily to adult male rats for 21 days. Protein and mRNA levels of cytokines and other inflammatory markers were measured in the frontal cortex using immunoblot and real-time PCR. Compared with chronic vehicle, chronic NMDA significantly increased protein and mRNA levels of interleukin-1beta, tumor necrosis factor alpha, glial fibrillary acidic protein and inducible nitric oxide synthase. Chronic NMDA receptor overactivation results in increased levels of neuroinflammatory markers in the rat frontal cortex, consistent with cross-talk between excitotoxicity and neuroinflammation. As both processes have been reported in a number of human brain diseases, NMDA receptor inhibitors might be of use in treating neuroinflammation in these diseases. JF - Neurochemical Research AU - Chang, Yunyoung C AU - Kim, Hyung-Wook AU - Rapoport, Stanley I AU - Rao, Jagadeesh S AD - National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bldg. 9, 1S-126, Bethesda, MD, 20892, USA, jrao@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 2318 EP - 2323 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 33 IS - 11 SN - 0364-3190, 0364-3190 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; CSA Neurosciences Abstracts KW - N-Methyl-D-aspartic acid receptors KW - Glial fibrillary acidic protein KW - Animal models KW - Brain KW - Enzymes KW - Cortex (frontal) KW - Arachidonic acid KW - Glutamic acid receptors (ionotropic) KW - mRNA KW - Inflammation KW - Nitric-oxide synthase KW - Polymerase chain reaction KW - Lipopolysaccharides KW - Tumor necrosis factor- alpha KW - Excitotoxicity KW - Metabolism KW - Phospholipids KW - Signal transduction KW - N3 11008:Neurochemistry KW - F 06910:Microorganisms & Parasites KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21062857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+Research&rft.atitle=Chronic+NMDA+Administration+Increases+Neuroinflammatory+Markers+in+Rat+Frontal+Cortex%3A+Cross-Talk+Between+Excitotoxicity+and+Neuroinflammation&rft.au=Chang%2C+Yunyoung+C%3BKim%2C+Hyung-Wook%3BRapoport%2C+Stanley+I%3BRao%2C+Jagadeesh+S&rft.aulast=Chang&rft.aufirst=Yunyoung&rft.date=2008-11-01&rft.volume=33&rft.issue=11&rft.spage=2318&rft.isbn=&rft.btitle=&rft.title=Neurochemical+Research&rft.issn=03643190&rft_id=info:doi/10.1007%2Fs11064-008-9731-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - N-Methyl-D-aspartic acid receptors; Brain; Animal models; Glial fibrillary acidic protein; Arachidonic acid; Cortex (frontal); Enzymes; Glutamic acid receptors (ionotropic); Inflammation; mRNA; Nitric-oxide synthase; Lipopolysaccharides; Polymerase chain reaction; Tumor necrosis factor- alpha; Metabolism; Excitotoxicity; Signal transduction; Phospholipids DO - http://dx.doi.org/10.1007/s11064-008-9731-8 ER - TY - JOUR T1 - A novel immunoregulatory axis of NKT cell subsets regulating tumor immunity AN - 20922018; 8490661 AB - There are many mechanisms that regulate and dampen the immune response to cancers, including several types of regulatory T cells. Besides the T reg cell, we have identified another immunoregulatory circuit initiated by NKT cells that produce IL-13 in response to tumor growth and this IL-13 then induces myeloid cells to make TGF- beta that inhibits cytotoxic T cell-mediated tumor immunosurveillance in several mouse tumor models. This finding created a paradox in the role of NKT cells in tumor immunity, in that they can also contribute to protection. We resolve this paradox by the finding that the suppressive NKT cell is a type II NKT cell that lacks the canonical invariant T cell receptor, whereas the protective cell is a type I NKT cell that expresses the invariant receptor. Further, we see that these two subsets of NKT cells counter-regulate each other, defining a new immunoregulatory axis. The balance along this axis may determine the outcome of tumor immunosurveillance as well as influence the efficacy of anti-cancer vaccines and immunotherapy. JF - Cancer Immunology, Immunotherapy AU - Berzofsky, Jay A AU - Terabe, Masaki AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA, berzofsk@helix.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1679 EP - 1683 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 57 IS - 11 SN - 0340-7004, 0340-7004 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Immunoregulation KW - Immunotherapy KW - double prime T-cell receptor KW - Animal models KW - Natural killer cells KW - Circuits KW - Tumors KW - Myeloid cells KW - Cancer KW - Interleukin 13 KW - Cytotoxicity KW - Immunosurveillance KW - Transforming growth factor- beta KW - Lymphocytes T KW - Vaccines KW - F 06915:Cancer Immunology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20922018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Immunology%2C+Immunotherapy&rft.atitle=A+novel+immunoregulatory+axis+of+NKT+cell+subsets+regulating+tumor+immunity&rft.au=Berzofsky%2C+Jay+A%3BTerabe%2C+Masaki&rft.aulast=Berzofsky&rft.aufirst=Jay&rft.date=2008-11-01&rft.volume=57&rft.issue=11&rft.spage=1679&rft.isbn=&rft.btitle=&rft.title=Cancer+Immunology%2C+Immunotherapy&rft.issn=03407004&rft_id=info:doi/10.1007%2Fs00262-008-0495-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Immunoregulation; double prime T-cell receptor; Immunotherapy; Natural killer cells; Animal models; Circuits; Tumors; Myeloid cells; Cancer; Cytotoxicity; Interleukin 13; Immunosurveillance; Transforming growth factor- beta; Lymphocytes T; Vaccines DO - http://dx.doi.org/10.1007/s00262-008-0495-4 ER - TY - JOUR T1 - Physical activity, sedentary behavior, and the risk of colon and rectal cancer in the NIH-AARP Diet and Health Study AN - 20731347; 8596771 AB - Objective: In order to prospectively investigate physical activity at varying intensities and sedentary behavior in relation to colorectal cancer. Methods: We considered 488,720 participants of the NIH-AARP Diet and Health Study who were aged 50-71 years at baseline in 1995-1996. Through 31 December, 2003, we identified 3,240 and 1,482 colorectal cancers among men and women, respectively. We estimated multivariable relative risks (RR) and 95% confidence intervals (CI) of colorectal cancer using Cox regression. Results: Engaging in exercise/sports five or more times per week compared to never or rarely exercising was associated with a reduced risk of colon cancer among men (p = 0.001; RR = 0.79, 95% CI = 0.68-0.91) and a suggestive decrease in risk among women (p = 0.376; RR = 0.85, 95% CI = 0.70-1.04). Engaging in exercise/sports was also associated with a decreased risk of rectal cancer in men (P = 0.074; RR comparing extreme categories = 0.76, 95% CI = 0.61-0.94). In men, we observed inverse relations of both low intensity (p = 0.017; RR = 0.81, 95% CI = 0.65-1.00 for greater than or equal to 7 h/week) and moderate to vigorous intensity activity (p = 0.037; RR = 0.82, 95% CI = 0.67-0.99 for greater than or equal to 7 h/week) to colon cancer risk. In contrast, sedentary behavior (time spent watching television/videos) was positively associated with colon cancer (p < 0.001; RR = 1.61, 95% CI = 1.14-2.27 for greater than or equal to 9 h/day) among men. Similar, but less pronounced relations were observed in women. Conclusion: Engaging in physical activity of any intensity is associated with reductions in colon and rectal cancer risk. Conversely, time spent sedentary is associated with increased colon cancer risk. JF - Cancer Causes & Control AU - Howard, Regan A AU - Freedman, DMichal AU - Park, Yikyung AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - National Cancer Institute, NIH, DHHS, Executive Plaza South, Suite 7091, Bethesda, MD, 20892, USA, reganho@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 939 EP - 953 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 19 IS - 9 SN - 0957-5243, 0957-5243 KW - Physical Education Index; Risk Abstracts KW - Diets KW - Men KW - Women KW - Health (behavior) KW - Exercise KW - Cancer KW - risk reduction KW - Behavior KW - colorectal carcinoma KW - Exercise (intensity) KW - Objectives KW - Television KW - Diet KW - physical activity KW - R2 23060:Medical and environmental health KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20731347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+in+Human+Behavior&rft.atitle=Cognitive-bias+toward+gaming-related+words+and+disinhibition+in+World+of+Warcraft+gamers&rft.au=Decker%2C+Seamus+A.%3BGay%2C+Jessica+N.&rft.aulast=Decker&rft.aufirst=Seamus&rft.date=2011-03-01&rft.volume=27&rft.issue=2&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Computers+in+Human+Behavior&rft.issn=07475632&rft_id=info:doi/10.1016%2Fj.chb.2010.11.005 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Behavior; Exercise (intensity); Men; Objectives; Women; Health (behavior); Diet; Exercise; Cancer; Diets; risk reduction; colorectal carcinoma; Television; physical activity DO - http://dx.doi.org/10.1007/s10552-008-9159-0 ER - TY - JOUR T1 - Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors AN - 20730759; 8596767 AB - Testicular germ cell tumors (TGCT) that arise in young men are composed of two histologic types, seminomas and nonseminomas. Risk patterns for the two types appear to be similar and may be related to either endogenous or exogenous hormonal exposures in utero. Why similar risk patterns would result in different histologic types is unclear, but could be related to varying genetic susceptibility profiles. Genetic variation in hormone metabolizing genes could potentially modify hormonal exposures, and thereby affect which histologic type a man develops. To examine this hypothesis, 33 single nucleotide polymorphisms (SNPs) in four hormone metabolism candidate genes (CYP1A1,CYP17A1,HSD17B1,HSD17B4) and the androgen receptor gene (AR) were genotyped. Associations with TGCT were evaluated among 577 TGCT cases (254 seminoma, 323 nonseminoma) and 707 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) study. There were no significant associations with TGCT overall based on a test using an additive model. However, compared to homozygotes of the most common allele, two nonredundant SNPs in CYP1A1 were inversely associated with nonseminoma: CYP1A1 promoter SNP rs4886605 OR = 0.75 (95% CI = 0.54-1.04) among the heterozygotes and OR = 0.37, 95% CI = 0.12-1.11 among the homozygotes with a p-value for trend = 0.02; rs2606345 intron 1 SNP, OR = 0.69 (95% CI = 0.51-0.93) among heterozygotes and OR = 0.70 (95% CI = 0.42-1.17) among homozygotes, with a p-value for trend = 0.02. Caution in interpretation is warranted until findings are replicated in other studies; however, the results suggest that genetic variation in CYP1A1 may be associated with nonseminoma. JF - Cancer Causes & Control AU - Figueroa, Jonine D AU - Sakoda, Lori C AU - Graubard, Barry I AU - Chanock, Stephen AU - Rubertone, Mark V AU - Erickson, RLoren AU - McGlynn, Katherine A AD - National Cancer Institute, Bethesda, MD, USA, figueroaj@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 917 EP - 929 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 19 IS - 9 SN - 0957-5243, 0957-5243 KW - Genetics Abstracts; Risk Abstracts; Toxicology Abstracts KW - Testes KW - Germ cells KW - Genetic diversity KW - tumors KW - genetic diversity KW - Tumors KW - Hormones KW - Cancer KW - Homozygotes KW - Androgen receptors KW - Promoters KW - introns KW - Single-nucleotide polymorphism KW - Heterozygotes KW - Introns KW - Cytochrome P450 KW - seminoma KW - Metabolism KW - X 24490:Other KW - R2 23060:Medical and environmental health KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20730759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Genetic+variation+in+hormone+metabolizing+genes+and+risk+of+testicular+germ+cell+tumors&rft.au=Figueroa%2C+Jonine+D%3BSakoda%2C+Lori+C%3BGraubard%2C+Barry+I%3BChanock%2C+Stephen%3BRubertone%2C+Mark+V%3BErickson%2C+RLoren%3BMcGlynn%2C+Katherine+A&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2008-11-01&rft.volume=19&rft.issue=9&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-008-9153-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Testes; Germ cells; Genetic diversity; Tumors; Hormones; Homozygotes; Androgen receptors; Promoters; Single-nucleotide polymorphism; Heterozygotes; Introns; Cytochrome P450; seminoma; Metabolism; introns; genetic diversity; tumors; Cancer DO - http://dx.doi.org/10.1007/s10552-008-9153-6 ER - TY - JOUR T1 - Modified Escherichia coli B (BL21), a superior producer of plasmid DNA compared with Escherichia coli K (DH5a) AN - 20688960; 10247951 AB - Plasmid DNA (pDNA) is an emerging experimental vaccine, produced in E. coli, initially targeted for viral diseases. Unlike traditional protein vaccines whose average dose is micrograms, the average dose of pDNA is on the scale of milligrams. Production yields are, therefore, important for the future development of this vaccine. The E. coli strains currently used for pDNA production, JM109 and DH5, are both suitable for production of stable pDNA due to the deletion of recA and endA, however, these two E. coli K strains are sensitive to growth conditions such as high glucose concentration. On the other hand E. coli BL21 is less sensitive to growth conditions than E. coli JM109 or DH5, this strain grows to higher densities and due to its active glyoxylate shunt and anaplerotic pathways is not sensitive to high glucose concentration. This strain is used for recombinant protein production but not for pDNA production because of its inability to produce stable pDNA. To adapt E. coli BL21 for stable pDNA production, the strain was mutated by deleting both recA and endA, and a proper growth and production strategy was developed. Production values, reaching 2 g/L were obtained using glucose as a carbon source. The produced plasmid, which was constructed for HIV clinical study, was found to have identical properties to the plasmid currently produced by E. coli DH5. Biotechnol. Bioeng. 2008; 101: 831-836. JF - Biotechnology and Bioengineering AU - Phue, Je-Nie AU - Lee, Sang Jun AU - Trinh, Loc AU - Shiloach, Joseph AD - Biotechnology Core Laboratory, NIDDK NIH Bethesda, Bldg 14A Room 173, Maryland 20892; 301-451-5911, yossi@nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 831 EP - 836 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 101 IS - 4 SN - 0006-3592, 0006-3592 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Human immunodeficiency virus KW - Growth conditions KW - Shunts KW - Escherichia coli KW - Glucose KW - DNA KW - Anaplerotic pathways KW - Vaccines KW - Carbon sources KW - Plasmids KW - RecA protein KW - V 22360:AIDS and HIV KW - J 02320:Cell Biology KW - N 14845:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20688960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Modified+Escherichia+coli+B+%28BL21%29%2C+a+superior+producer+of+plasmid+DNA+compared+with+Escherichia+coli+K+%28DH5a%29&rft.au=Phue%2C+Je-Nie%3BLee%2C+Sang+Jun%3BTrinh%2C+Loc%3BShiloach%2C+Joseph&rft.aulast=Phue&rft.aufirst=Je-Nie&rft.date=2008-11-01&rft.volume=101&rft.issue=4&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/10.1002%2Fbit.21973 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Growth conditions; Shunts; DNA; Glucose; Anaplerotic pathways; Carbon sources; Vaccines; Plasmids; RecA protein; Human immunodeficiency virus; Escherichia coli DO - http://dx.doi.org/10.1002/bit.21973 ER - TY - JOUR T1 - Variation in lung cancer risk by smoky coal subtype in Xuanwei, China AN - 20626269; 9355885 AB - Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age (±2 years) and sex to examine risk by coal subtype. Odds ratios (ORs) and 95% confidence intervals (CIs) for coal subtype were calculated by conditional logistic regression, adjusting for potential confounders. Overall, smoky coal use was positively and statistically significantly associated with lung cancer risk, when compared with the use of smokeless coal or wood (OR = 7.7, 95% CI = 4.5-13.3). Furthermore, there was a marked heterogeneity in risk estimates for specific subtypes of smoky coal (test for heterogeneity: p = 5.17 X 10-10). Estimates were highest for coal of the Laibin (OR = 24.8, 95% CI = 12.4-49.6) and Longtan (OR = 11.6, 95% CI = 5.0-27.2) coal types and lower for coal from other subtypes. These findings strongly suggest that in Xuanwei and elsewhere, the carcinogenic potential of coal combustion products can exhibit substantial local variation by specific coal source. Published 2008 Wiley-Liss, Inc. JF - International Journal of Cancer AU - Lan, Qing AU - He, Xingzhou AU - Shen, Min AU - Tian, Linwei AU - Liu, Larry Z AU - Lai, Hong AU - Chen, Wei AU - Berndt, Sonja I AU - Hosgood, Howard Dean AU - Lee, Kyoung-Mu AU - Zheng, Tongzhang AU - Blair, Aaron AU - Chapman, Robert S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, qingl@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 2164 EP - 2169 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 123 IS - 9 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Age KW - Carcinogenicity KW - Combustion products KW - Emissions KW - Wood KW - polycyclic aromatic hydrocarbons KW - China, People's Rep. KW - Coal KW - Mines KW - Cancer KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20626269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Variation+in+lung+cancer+risk+by+smoky+coal+subtype+in+Xuanwei%2C+China&rft.au=Lan%2C+Qing%3BHe%2C+Xingzhou%3BShen%2C+Min%3BTian%2C+Linwei%3BLiu%2C+Larry+Z%3BLai%2C+Hong%3BChen%2C+Wei%3BBerndt%2C+Sonja+I%3BHosgood%2C+Howard+Dean%3BLee%2C+Kyoung-Mu%3BZheng%2C+Tongzhang%3BBlair%2C+Aaron%3BChapman%2C+Robert+S&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2008-11-01&rft.volume=123&rft.issue=9&rft.spage=2164&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23748 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Combustion products; Carcinogenicity; Emissions; polycyclic aromatic hydrocarbons; Wood; Coal; Mines; Cancer; Lung cancer; China, People's Rep. DO - http://dx.doi.org/10.1002/ijc.23748 ER - TY - JOUR T1 - Radiation Dose to the Brain and Subsequent Risk of Developing Brain Tumors in Pediatric Patients Undergoing Interventional Neuroradiology Procedures AN - 20265122; 8904586 AB - Thierry-Chef, I., Simon, S. L., Land, C. E. and Miller, D. L. Radiation Dose to the Brain and Subsequent Risk of Developing Brain Tumors in Pediatric Patients Undergoing Interventional Neuroradiology Procedures. Radiat. Res. 170, 553- 565 (2008). Radiation dose to the brain and subsequent lifetime risk of diagnosis of radiation-related brain tumors were estimated for pediatric patients undergoing intracranial embolization. Average dose to the whole brain was calculated using dosimetric data from the Radiation Doses in Interventional Radiology Study for 49 pediatric patients who underwent neuroradiological procedures, and lifetime risk of developing radiation-related brain tumors was estimated using published algorithms based on A-bomb survivor data. The distribution of absorbed dose within the brain can vary significantly depending on field size and movement during procedures. Depending on the exposure conditions and age of the patient, organ-averaged brain dose was estimated to vary from 6 to 1600 mGy. The lifetime risk of brain tumor diagnosis was estimated to be increased over the normal background rates (57 cases per 10,000) by 3 to 40% depending on the dose received, age at exposure, and gender. While significant uncertainties are associated with these estimates, we have quantified the range of possible dose and propagated the uncertainty to derive a credible range of estimated lifetime risk for each subject. Collimation and limiting fluoroscopy time and dose rate are the most effective means to minimize dose and risk of future induction of radiation-related tumors. JF - Radiation Research AU - Thierry-Chef, I AU - Simon, S L AU - Land, CE AU - Miller, D L AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; , thierrychefi@iarc.fr Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 553 EP - 565 PB - Radiation Research Society VL - 170 IS - 5 SN - 0033-7587, 0033-7587 KW - Biotechnology and Bioengineering Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Age KW - Algorithms KW - Radiation KW - Embolization KW - Data processing KW - Pediatrics KW - Radiology KW - Brain tumors KW - fluoroscopy KW - X 24390:Radioactive Materials KW - N3 11027:Neurology & neuropathology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20265122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Radiation+Dose+to+the+Brain+and+Subsequent+Risk+of+Developing+Brain+Tumors+in+Pediatric+Patients+Undergoing+Interventional+Neuroradiology+Procedures&rft.au=Thierry-Chef%2C+I%3BSimon%2C+S+L%3BLand%2C+CE%3BMiller%2C+D+L&rft.aulast=Thierry-Chef&rft.aufirst=I&rft.date=2008-11-01&rft.volume=170&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR1393.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Brain tumors; Radiation; Pediatrics; Data processing; Age; fluoroscopy; Algorithms; Embolization; Radiology DO - http://dx.doi.org/10.1667/RR1393.1 ER - TY - JOUR T1 - Development of optimal bicistronic lentiviral vectors facilitates high- level TCR gene expression and robust tumor cell recognition AN - 20054172; 8570610 AB - In human gene therapy applications, lentiviral vectors may have advantages over [gamma]-retroviral vectors in several areas, including the ability to transduce nondividing cells, resistance to gene silencing and a potentially safer integration site profile. However, unlike [gamma]- retroviral vectors it has been problematic to drive the expression of multiple genes efficiently and coordinately with approaches such as internal ribosome entry sites or dual promoters. Using different 2A peptides, lentiviral vectors expressing two-gene T-cell receptors directed against the melanoma differentiation antigens gp100 and MART-1 were constructed. We demonstrated that addition of amino-acid spacer sequences (GSG or SGSG) before the 2A sequence is a prerequisite for efficient synthesis of biologically active T-cell receptors and that addition of a furin cleavage site followed by a V5 peptide tag yielded optimal T-cell receptor gene expression. Furthermore, we determined that the furin cleavage site was recognized in lymphocytes and accounted for removal of residual 2A peptides at the post-translational level with an efficiency of 20-30%, which could not be increased by addition of multiple furin cleavage sites. The novel bicistronic lentiviral vector developed herein afforded robust anti-melanoma activities to engineered peripheral blood lymphocytes, including cytokine secretion, cell proliferation and lytic activity. Such optimal vectors may have immediate applications in cancer gene therapy. JF - Gene Therapy AU - Yang, S AU - Cohen, C J AU - Peng, P D AU - Zhao, Y AU - Cassard, L AU - Yu, Z AU - Zheng, Z AU - Jones, S AU - Restifo, N P AU - Rosenberg, S A AU - Morgan, R A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, rmorgan@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1411 EP - 1423 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 15 IS - 21 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - T-cell receptor KW - adoptive immunotherapy KW - tumor immunity KW - lentivirus KW - 2A peptide KW - Gene therapy KW - Spacer KW - Peripheral blood KW - Lymphocytes KW - Tumor cells KW - Cancer KW - furin KW - Melanoma KW - Expression vectors KW - Promoters KW - Differentiation KW - Integration KW - MART-1 antigen KW - Post-translation KW - Antigen (tumor-associated) KW - Glycoprotein gp100 KW - Cytokines KW - Internal ribosome entry site KW - Cell proliferation KW - Gene silencing KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - V 22350:Immunology KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20054172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Development+of+optimal+bicistronic+lentiviral+vectors+facilitates+high-+level+TCR+gene+expression+and+robust+tumor+cell+recognition&rft.au=Yang%2C+S%3BCohen%2C+C+J%3BPeng%2C+P+D%3BZhao%2C+Y%3BCassard%2C+L%3BYu%2C+Z%3BZheng%2C+Z%3BJones%2C+S%3BRestifo%2C+N+P%3BRosenberg%2C+S+A%3BMorgan%2C+R+A&rft.aulast=Yang&rft.aufirst=S&rft.date=2008-11-01&rft.volume=15&rft.issue=21&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2008.90 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - T-cell receptor; Gene therapy; Peripheral blood; Spacer; Lymphocytes; Tumor cells; Cancer; Melanoma; furin; Expression vectors; Integration; Differentiation; Promoters; MART-1 antigen; Post-translation; Glycoprotein gp100; Antigen (tumor-associated); Internal ribosome entry site; Cytokines; Cell proliferation; Gene silencing DO - http://dx.doi.org/10.1038/gt.2008.90 ER - TY - JOUR T1 - Genetic Control of Variegated KIR Gene Expression: Polymorphisms of the Bi-Directional KIR3DL1 Promoter Are Associated with Distinct Frequencies of Gene Expression AN - 19917152; 8819488 AB - Natural killer (NK) cells play an important role in the detection and elimination of tumors and virus-infected cells by the innate immune system. Human NK cells use cell surface receptors (KIR) for class I MHC to sense alterations of class I on potential target cells. Individual NK cells only express a subset of the available KIR genes, generating specialized NK cells that can specifically detect alteration of a particular class I molecule or group of molecules. The probabilistic behavior of human KIR bi-directional promoters is proposed to control the frequency of expression of these variegated genes. Analysis of a panel of donors has revealed the presence of several functionally relevant promoter polymorphisms clustered mainly in the inhibitory KIR family members, especially the KIR3DL1 alleles. We demonstrate for the first time that promoter polymorphisms affecting the strength of competing sense and antisense promoters largely explain the differential frequency of expression of KIR3DL1 allotypes on NK cells. KIR3DL1/S1 subtypes have distinct biological activity and coding region variants of the KIR3DL1/S1 gene strongly influence pathogenesis of HIV/AIDS and other human diseases. We propose that the polymorphisms shown in this study to regulate the frequency of KIR3DL1/S1 subtype expression on NK cells contribute substantially to the phenotypic variation across allotypes with respect to disease resistance. Author Summary Natural killer (NK) cells represent a specialized blood cell that plays an important role in the detection of virus-infected or cancer cells. NK cells recognize and kill diseased cells using receptors for self antigens (HLA) that are frequently altered on aberrant cells. The HLA receptors are known as Killer cell Immunoglobulin-like Receptors, or KIR. Humans possess from four to 14 KIR receptor genes in their genome, and individual NK cells express a subset of the available KIR genes, generating specialized NK cells that detect alterations in specific HLA proteins. The mechanism of this unusual selective gene activation was recently shown by our group to be controlled by a probabilistic bi-directional promoter switch that turns on a given gene at a pre-determined frequency in the NK cell population. The current study shows that the properties of the switches in terms of the relative activity of forward (on) versus reverse (off) promoter activity is directly correlated with the frequency at which a given gene is expressed within the NK cell population. These results have important implications for our understanding of the role of NK cells in viral resistance and bone marrow transplants. JF - PLoS Genetics AU - Li, Hongchuan AU - Pascal, Veronique AU - Martin, Maureen P AU - Carrington, Mary AU - Anderson, Stephen K AU - Roopenian, Derry C AD - Basic Research Program, SAIC-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland, United States of America Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1 PB - Public Library of Science, 185 Berry Street VL - 4 IS - 11 SN - 1553-7390, 1553-7390 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Histocompatibility antigen HLA KW - Genomes KW - Cell surface KW - Acquired immune deficiency syndrome KW - Gene polymorphism KW - Immune system KW - Major histocompatibility complex KW - Disease resistance KW - Gene expression KW - Promoters KW - Antisense KW - Potassium channels (inwardly-rectifying) KW - Blood cells KW - Bone marrow transplantation KW - Natural killer cells KW - Allotypes KW - Tumors KW - KIR protein KW - Autoantigens KW - Cancer KW - Human immunodeficiency virus KW - Killer cell immunoglobulin-like receptors KW - Genetic control KW - Transcription activation KW - S1 gene KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19917152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Genetics&rft.atitle=Genetic+Control+of+Variegated+KIR+Gene+Expression%3A+Polymorphisms+of+the+Bi-Directional+KIR3DL1+Promoter+Are+Associated+with+Distinct+Frequencies+of+Gene+Expression&rft.au=Li%2C+Hongchuan%3BPascal%2C+Veronique%3BMartin%2C+Maureen+P%3BCarrington%2C+Mary%3BAnderson%2C+Stephen+K%3BRoopenian%2C+Derry+C&rft.aulast=Li&rft.aufirst=Hongchuan&rft.date=2008-11-01&rft.volume=4&rft.issue=11&rft.spage=e1000254&rft.isbn=&rft.btitle=&rft.title=PLoS+Genetics&rft.issn=15537390&rft_id=info:doi/10.1371%2Fjournal.pgen.1000254 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Histocompatibility antigen HLA; Cell surface; Acquired immune deficiency syndrome; Immune system; Gene polymorphism; Natural killer cells; Major histocompatibility complex; Allotypes; Disease resistance; Tumors; Cancer; Autoantigens; KIR protein; Gene expression; Promoters; Antisense; Potassium channels (inwardly-rectifying); Killer cell immunoglobulin-like receptors; Genetic control; Blood cells; Transcription activation; Bone marrow transplantation; S1 gene; Human immunodeficiency virus DO - http://dx.doi.org/10.1371/journal.pgen.1000254 ER - TY - JOUR T1 - Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity AN - 19803751; 8590973 AB - Genome endoreduplication during mammalian development is a rare event for which the mechanism is unknown. It first appears when fibroblast growth factor 4 (FGF4) deprivation induces differentiation of trophoblast stem (TS) cells into the nonproliferating trophoblast giant (TG) cells required for embryo implantation. Here we show that RO3306 inhibition of cyclin-dependent protein kinase 1 (CDK1), the enzyme required to enter mitosis, induced differentiation of TS cells into TG cells. In contrast, RO3306 induced abortive endoreduplication and apoptosis in embryonic stem cells, revealing that inactivation of CDK1 triggers endoreduplication only in cells programmed to differentiate into polyploid cells. Similarly, FGF4 deprivation resulted in CDK1 inhibition by overexpressing two CDK-specific inhibitors, p57/KIP2 and p21/CIP1. TS cell mutants revealed that p57 was required to trigger endoreduplication by inhibiting CDK1, while p21 suppressed expression of the checkpoint protein kinase CHK1, thereby preventing induction of apoptosis. Furthermore, Cdk2 super(-/-) TS cells revealed that CDK2 is required for endoreduplication when CDK1 is inhibited. Expression of p57 in TG cells was restricted to G-phase nuclei to allow CDK activation of S phase. Thus, endoreduplication in TS cells is triggered by p57 inhibition of CDK1 with concomitant suppression of the DNA damage response by p21. JF - Genes & Development AU - Ullah, Zakir AU - Kohn, Matthew J AU - Yagi, Rieko AU - Vassilev, Lyubomir T AU - DePamphilis, Melvin L AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Ajinomoto Institute of Life Science, Kawasaki 210-8681, Japan. Department of Discovery Oncology, Roche Research Center, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110, USA Y1 - 2008/11/01/ PY - 2008 DA - 2008 Nov 01 SP - 3024 EP - 3036 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 22 IS - 21 SN - 0890-9369, 0890-9369 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Protein kinase C KW - Endoreduplication KW - Giant cells KW - Genomes KW - Polyploidy KW - Apoptosis KW - Enzymes KW - Trophoblasts KW - DNA damage KW - Differentiation KW - Fibroblast growth factor 4 KW - Stem cells KW - Embryo cells KW - Cyclin-dependent kinase KW - S phase KW - Mitosis KW - Protein kinase KW - Nuclei KW - Cyclin-dependent kinase 2 KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19803751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Differentiation+of+trophoblast+stem+cells+into+giant+cells+is+triggered+by+p57%2FKip2+inhibition+of+CDK1+activity&rft.au=Ullah%2C+Zakir%3BKohn%2C+Matthew+J%3BYagi%2C+Rieko%3BVassilev%2C+Lyubomir+T%3BDePamphilis%2C+Melvin+L&rft.aulast=Ullah&rft.aufirst=Zakir&rft.date=2008-11-01&rft.volume=22&rft.issue=21&rft.spage=3024&rft.isbn=&rft.btitle=&rft.title=Genes+%26+Development&rft.issn=08909369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Giant cells; Endoreduplication; Protein kinase C; Apoptosis; Polyploidy; Trophoblasts; Enzymes; Differentiation; DNA damage; Stem cells; Fibroblast growth factor 4; Cyclin-dependent kinase; Embryo cells; S phase; Mitosis; Protein kinase; Cyclin-dependent kinase 2; Nuclei ER - TY - JOUR T1 - Relationship of p53 Overexpression on Cancers and Recognition by Anti-p53 T Cell Receptor-Transduced T Cells AN - 19800736; 8852252 AB - Tumor suppressor p53 is reported to be an attractive immunotherapy target because it is mutated in approximately half of human cancers, resulting in inactivation and often an accumulation of the protein in the tumor cells. Only low amounts of protein are detectable in normal tissues. The differential display of antigen in normal versus tumor tissues has been reported to create an opportunity to target p53 by immunotherapy. We sought to determine the relationship between p53 expression and its recognition by cognate T cells in human tumors including common epithelial malignancies. Inasmuch as nonsense or missense p53 mutations may disrupt processing and presentation, we studied tumors with either identified wild-type or mutated p53, based on our gene-sequencing studies or published data. T cells transduced with a high-affinity, p53 sub(264-272)-reactive T cell receptor (TCR) derived from HLA-A2.1 transgenic mice recognized a wide panel of human tumor lines. There was no significant correlation between p53 expression in tumors and recognition by the anti-p53 TCR-transduced T cells. This conclusion was based on the study of 48 cell lines and is in contrast to several prior studies that used only a limited number of selected cell lines. A panel of normal cells was evaluated for recognition, and some of these populations were capable of stimulating anti-p53 T cells, albeit at low levels. These studies raise doubts concerning the suitability of targeting p53 in the immunotherapy of cancer patients. JF - Human Gene Therapy AU - Theoret, M R AU - Cohen, C J AU - Nahvi, A V AU - Ngo, L T AU - Suri, K B AU - Powell, DJ Jr AU - Dudley, ME AU - Morgan, R A AU - Rosenberg, SA AD - Surgery Branch, Building 10-CRC, Room 3W3-3940, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC 1201, Bethesda, MD 20892-1201, USA, sar@nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1219 EP - 1231 VL - 19 IS - 11 SN - 1043-0342, 1043-0342 KW - Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Histocompatibility antigen HLA KW - Tumor suppressor genes KW - Data processing KW - Gene therapy KW - Immunotherapy KW - double prime T-cell receptor KW - Tumors KW - Transgenic mice KW - Tumor cells KW - Cancer KW - p53 protein KW - Malignancy KW - Lymphocytes T KW - Mutation KW - Differential display KW - W 30905:Medical Applications KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19800736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Relationship+of+p53+Overexpression+on+Cancers+and+Recognition+by+Anti-p53+T+Cell+Receptor-Transduced+T+Cells&rft.au=Theoret%2C+M+R%3BCohen%2C+C+J%3BNahvi%2C+A+V%3BNgo%2C+L+T%3BSuri%2C+K+B%3BPowell%2C+DJ+Jr%3BDudley%2C+ME%3BMorgan%2C+R+A%3BRosenberg%2C+SA&rft.aulast=Theoret&rft.aufirst=M&rft.date=2008-11-01&rft.volume=19&rft.issue=11&rft.spage=1219&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2008.083 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Tumor suppressor genes; Data processing; Gene therapy; double prime T-cell receptor; Immunotherapy; Tumors; Transgenic mice; Tumor cells; Cancer; p53 protein; Malignancy; Lymphocytes T; Mutation; Differential display DO - http://dx.doi.org/10.1089/hum.2008.083 ER - TY - JOUR T1 - Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusion-competent G protein of vesicular stomatitis virus AN - 19749647; 8607731 AB - Exosomes have been proposed as candidates for therapeutic immunization. The present study demonstrates that incorporation of the G protein of vesicular stomatitis virus (VSV-G) into exosome-like vesicles (ELVs) enhances their uptake and induces the maturation of dendritic cells. Targeting of VSV- G and ovalbumin as a model antigen to the same ELVs increased the cross- presentation of ovalbumin via an endosomal acidification mechanism. Immunization of mice with VSV-G and ovalbumin containing ELVs led to an increased IgG2a antibody response, expansion of antigen-specific CD8 T cells, strong in vivo CTL responses, and protection from challenge with ovalbumin expressing tumor cells. Thus, incorporation of VSV-G and targeting of antigens to ELVs are attractive strategies to improve exosomal vaccines. JF - Vaccine AU - Temchura, Vladimir V AU - Tenbusch, Matthias AU - Nchinda, Godwin AU - Nabi, Ghulam AU - Tippler, Bettina AU - Zelenyuk, Maryna AU - Wildner, Oliver AU - Uberla, Klaus AU - Kuate, Seraphin AD - Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum D-44780, Germany, kuates@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 3662 EP - 3672 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 48 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Exosomes KW - VSV-G KW - Vaccines KW - Ovalbumin KW - exosomes KW - Animal models KW - CD8 antigen KW - Antibody response KW - Antigen presentation KW - Tumor cells KW - Immunization KW - Dendritic cells KW - Cytotoxicity KW - Immunostimulation KW - Lymphocytes T KW - Immunoglobulin G KW - Vesicles KW - Acidification KW - Vesicular stomatitis virus KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19749647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Enhancement+of+immunostimulatory+properties+of+exosomal+vaccines+by+incorporation+of+fusion-competent+G+protein+of+vesicular+stomatitis+virus&rft.au=Temchura%2C+Vladimir+V%3BTenbusch%2C+Matthias%3BNchinda%2C+Godwin%3BNabi%2C+Ghulam%3BTippler%2C+Bettina%3BZelenyuk%2C+Maryna%3BWildner%2C+Oliver%3BUberla%2C+Klaus%3BKuate%2C+Seraphin&rft.aulast=Temchura&rft.aufirst=Vladimir&rft.date=2008-11-01&rft.volume=26&rft.issue=48&rft.spage=3662&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.04.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ovalbumin; exosomes; Animal models; Antibody response; CD8 antigen; Antigen presentation; Tumor cells; Immunization; Dendritic cells; Cytotoxicity; Immunostimulation; Immunoglobulin G; Lymphocytes T; Vesicles; Vaccines; Acidification; Vesicular stomatitis virus DO - http://dx.doi.org/10.1016/j.vaccine.2008.04.069 ER - TY - JOUR T1 - Evaluation of systemic and mucosal anti-HPV16 and anti-HPV18 antibody responses from vaccinated women AN - 19743623; 8607721 AB - Ideal methods to monitor HPV neutralizing antibodies induced by vaccination have not been established yet. Here, we evaluated systemic and cervical antibody levels induced by HPV16/18 AS04-adjuvanted vaccine (GlaxoSmithKline Biologicals) using a secreted alkaline phosphatase neutralization assay (SEAP-NA) and enzyme-linked immunosorbent assay (ELISA). Serum and cervical secretions from 50 vaccinated women were used to assess (1) overall assay reproducibility; (2) inter-assay and inter-specimen correlation; (3) correlations between month 1 and month 12 titers. Strong correlations between SEAP-NA and ELISA were observed (serum anti-HPV16/18, [rho] = 0.91/0.85; cervix anti-HPV16/18, [rho] = 0.84/0.89). Systemic and cervical antibody measures also correlated well ([rho] range: 0.64- 0.75); except at mid-cycle ([rho] range: 0.28-0.65). Correlations between antibody levels at 1 and 12 months following the start of vaccination were poor ([rho] range: 0.16-0.38). In conclusion, HPV16/18 VLP-based ELISA is a reliable and valid method to monitor anti-HPV16/18 neutralizing potential for the first year following vaccination; however, additional studies will be required to better define the effects of the time on cycle and patterns of antibody response over time following vaccination. JF - Vaccine AU - Kemp, Troy J AU - Garcia-Pineres, Alfonso AU - Falk, Roni T AU - Poncelet, Sylviane AU - Dessy, Francis AU - Giannini, Sandra L AU - Rodriguez, Ana Cecilia AU - Porras, Carolina AU - Herrero, Rolando AU - Hildesheim, Allan AU - Pinto, Ligia A AD - HPV Immunology Laboratory, SAIC-Frederick Inc., NCI-Frederick, Building 469, Room 120, Frederick, MD 21702, USA, lpinto@ncifcrf.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 3608 EP - 3616 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 48 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Human papillomavirus KW - Neutralization assay KW - Cervical secretions KW - Enzyme-linked immunosorbent assay KW - Alkaline phosphatase KW - Human papillomavirus 16 KW - Secretions KW - Mucosa KW - Vaccines KW - Antibody response KW - Cervix KW - Vaccination KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19743623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Evaluation+of+systemic+and+mucosal+anti-HPV16+and+anti-HPV18+antibody+responses+from+vaccinated+women&rft.au=Kemp%2C+Troy+J%3BGarcia-Pineres%2C+Alfonso%3BFalk%2C+Roni+T%3BPoncelet%2C+Sylviane%3BDessy%2C+Francis%3BGiannini%2C+Sandra+L%3BRodriguez%2C+Ana+Cecilia%3BPorras%2C+Carolina%3BHerrero%2C+Rolando%3BHildesheim%2C+Allan%3BPinto%2C+Ligia+A&rft.aulast=Kemp&rft.aufirst=Troy&rft.date=2008-11-01&rft.volume=26&rft.issue=48&rft.spage=3608&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.04.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Alkaline phosphatase; Mucosa; Secretions; Antibody response; Vaccines; Cervix; Vaccination; Human papillomavirus 16 DO - http://dx.doi.org/10.1016/j.vaccine.2008.04.074 ER - TY - JOUR T1 - Brain mu-opioid receptor binding: relationship to relapse to cocaine use after monitored abstinence AN - 19688116; 8598011 AB - Rationale: Cocaine users have increased regional brain mu-opioid receptor (mOR) binding which correlates with cocaine craving. The relationship of mOR binding to relapse is unknown. Objective: To evaluate regional brain mOR binding as a predictor of relapse to cocaine use is the objective of the study. Materials and methods: Fifteen nontreatment-seeking, adult cocaine users were housed on a closed research ward for 12 weeks of monitored abstinence and then followed for up to 1 year after discharge. Regional brain mOR binding was measured after 1 and 12 weeks using positron emission tomography (PET) with [ super(11)C]carfentanil (a selective mOR agonist). Time to first cocaine use (lapse) and to first two consecutive days of cocaine use (relapse) after discharge was based on self-report and urine toxicology. Results: A shorter interval before relapse was associated with increased mOR binding in frontal and temporal cortical regions at 1 and 12 weeks of abstinence (Ps < 0.001) and with a lesser decrease in binding between 1 and 12 weeks (Ps < 0.0008). There were significant positive correlations between mOR binding at 12 weeks and percent days of cocaine use during first month after relapse (Ps < 0.002). In multiple linear regression analysis, mOR binding contributed significantly to the prediction of time to relapse (R super(2 )= 0.79, P < 0.001), even after accounting for clinical variables. Conclusions: Increased brain mOR binding in frontal and temporal cortical regions is a significant independent predictor of time to relapse to cocaine use, suggesting an important role for the brain endogenous opioid system in cocaine addiction. JF - Psychopharmacology AU - Gorelick, David A AU - Kim, Yu Kyeong AU - Bencherif, Badreddine AU - Boyd, Susan J AU - Nelson, Richard AU - Copersino, Marc L AU - Dannals, Robert F AU - Frost, JJames AD - NIDA IRP, 251 Bayview Boulevard, suite 200, Baltimore, 21224, MD, USA, dgorelic@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 475 EP - 486 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 200 IS - 4 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Cortex KW - Urine KW - Brain KW - Positron emission tomography KW - Regression analysis KW - Opioid receptors (type mu) KW - Opioids KW - Addiction KW - Cocaine KW - Drug abuse KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19688116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Brain+mu-opioid+receptor+binding%3A+relationship+to+relapse+to+cocaine+use+after+monitored+abstinence&rft.au=Gorelick%2C+David+A%3BKim%2C+Yu+Kyeong%3BBencherif%2C+Badreddine%3BBoyd%2C+Susan+J%3BNelson%2C+Richard%3BCopersino%2C+Marc+L%3BDannals%2C+Robert+F%3BFrost%2C+JJames&rft.aulast=Gorelick&rft.aufirst=David&rft.date=2008-11-01&rft.volume=200&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-008-1225-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cortex; Urine; Regression analysis; Positron emission tomography; Brain; Opioids; Opioid receptors (type mu); Addiction; Drug abuse; Cocaine DO - http://dx.doi.org/10.1007/s00213-008-1225-5 ER - TY - JOUR T1 - A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial AN - 19686569; 8685532 AB - Background - The severe acute respiratory syndrome (SARS) virus is a member of the Coronaviridae (CoV) family that first appeared in the Guangdong Province of China in 2002 and was recognized as an emerging infectious disease in March 2003. Over 8000 cases and 900 deaths occurred during the epidemic. We report the safety and immunogenicity of a SARS DNA vaccine in a Phase I human study. Methods - A single-plasmid DNA vaccine encoding the Spike (S) glycoprotein was evaluated in 10 healthy adults. Nine subjects completed the 3 dose vaccination schedule and were evaluated for vaccine safety and immune responses. Immune response was assessed by intracellular cytokine staining (ICS), ELISpot, ELISA, and neutralization assays. Results - The vaccine was well tolerated. SARS-CoV-specific antibody was detected by ELISA in 8 of 10 subjects and neutralizing antibody was detected in all subjects who received 3 doses of vaccine. SARS-CoV-specific CD4+ T-cell responses were detected in all vaccinees, and CD8+ T-cell responses in [not, vert, similar]20% of individuals. Conclusions - The VRC SARS DNA vaccine was well tolerated and produced cellular immune responses and neutralizing antibody in healthy adults. JF - Vaccine AU - Martin, Julie E AU - Louder, Mark K AU - Holman, LaSonji A AU - Gordon, Ingelise J AU - Enama, Mary E AU - Larkin, Brenda D AU - Andrews, Charla A AU - Vogel, Leatrice AU - Koup, Richard A AU - Roederer, Mario AU - Bailer, Robert T AU - Gomez, Phillip L AU - Nason, Martha AU - Mascola, John R AU - Nabel, Gary J AU - Graham, Barney S AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, MSC-2610, Bethesda, MD 20892-3017, USA, bgraham@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 6338 EP - 6343 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 50 SN - 0264-410X, 0264-410X KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - T-cell vaccine KW - Emerging infectious disease KW - Vaccine clinical trial KW - vaccines KW - clinical trials KW - Clinical trials KW - China, People's Rep., Guangdong Prov. KW - CD4 antigen KW - Infectious diseases KW - DNA vaccines KW - Lymphocytes T KW - Cytokines KW - Glycoproteins KW - Neutralization KW - Mortality KW - Enzyme-linked immunosorbent assay KW - Epidemics KW - Coronaviridae KW - severe acute respiratory syndrome KW - Severe acute respiratory syndrome KW - immunogenicity KW - CD8 antigen KW - glycoproteins KW - Antibodies KW - Immunogenicity KW - DNA KW - Immune response KW - SARS coronavirus KW - V 22350:Immunology KW - H 1000:Occupational Safety and Health KW - F 06910:Microorganisms & Parasites KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=A+SARS+DNA+vaccine+induces+neutralizing+antibody+and+cellular+immune+responses+in+healthy+adults+in+a+Phase+I+clinical+trial&rft.au=Martin%2C+Julie+E%3BLouder%2C+Mark+K%3BHolman%2C+LaSonji+A%3BGordon%2C+Ingelise+J%3BEnama%2C+Mary+E%3BLarkin%2C+Brenda+D%3BAndrews%2C+Charla+A%3BVogel%2C+Leatrice%3BKoup%2C+Richard+A%3BRoederer%2C+Mario%3BBailer%2C+Robert+T%3BGomez%2C+Phillip+L%3BNason%2C+Martha%3BMascola%2C+John+R%3BNabel%2C+Gary+J%3BGraham%2C+Barney+S&rft.aulast=Martin&rft.aufirst=Julie&rft.date=2008-11-01&rft.volume=26&rft.issue=50&rft.spage=6338&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2008.09.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Epidemics; Severe acute respiratory syndrome; CD8 antigen; Clinical trials; Antibodies; CD4 antigen; DNA vaccines; Infectious diseases; Immunogenicity; Lymphocytes T; Cytokines; Glycoproteins; Immune response; glycoproteins; Mortality; vaccines; severe acute respiratory syndrome; immunogenicity; DNA; clinical trials; Neutralization; Coronaviridae; SARS coronavirus; China, People's Rep., Guangdong Prov. DO - http://dx.doi.org/10.1016/j.vaccine.2008.09.026 ER - TY - JOUR T1 - The Changing Face of Biomedical Research in Tuberculosis AN - 19617388; 8604316 AB - Tuberculosis (TB) remains a significant cause of morbidity and mortality despite improvements in detection and treatment. Current global control strategies are not sufficient to significantly affect TB rates worldwide and are unlikely to meet global targets without new diagnostic tests, drugs, and vaccines. Increasing rates of drug-resistant TB coupled with co-infection in people with HIV infection, threaten to reverse gains made in controlling both diseases. Control of TB includes many interconnected components. NIH/NIAID supports fundamental, translational, and clinical TB studies and provides resources to facilitate research on candidate products. In an era of limited government funding, clinical use of candidate products, and a changing landscape of organizations participating in TB research and development, it is critical to re-evaluate each partner's contributions. This rethinking will ensure that limited resources focus on medical gaps, and tasks are undertaken by the most suitable organizations. Collaborative efforts are essential to advance in TB research and development. JF - Clinical Microbiology Newsletter AU - Ph.D., Christine Sizemore AU - Ph.D., Carole Heilman AD - Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, csizemore@niaid.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 167 EP - 171 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 30 IS - 22 SN - 0196-4399, 0196-4399 KW - Microbiology Abstracts B: Bacteriology KW - Translation KW - Mortality KW - Human immunodeficiency virus KW - Mycobacterium KW - Drug resistance KW - Landscape KW - Tuberculosis KW - Vaccines KW - Infection KW - Drugs KW - Morbidity KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19617388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Newsletter&rft.atitle=The+Changing+Face+of+Biomedical+Research+in+Tuberculosis&rft.au=Ph.D.%2C+Christine+Sizemore%3BPh.D.%2C+Carole+Heilman&rft.aulast=Ph.D.&rft.aufirst=Christine&rft.date=2008-11-01&rft.volume=30&rft.issue=22&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Newsletter&rft.issn=01964399&rft_id=info:doi/10.1016%2Fj.clinmicnews.2008.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Translation; Drug resistance; Landscape; Tuberculosis; Vaccines; Infection; Drugs; Morbidity; Mycobacterium; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.clinmicnews.2008.10.002 ER - TY - JOUR T1 - Context dependent function of APPb enhancer identified using enhancer trap-containing BACs as transgenes in zebrafish AN - 19589693; 8781718 AB - An enhancer within intron 1 of the amyloid precursor protein gene (APPb) of zebrafish is identified functionally using a novel approach. Bacterial artificial chromosomes (BACs) were retrofitted with enhancer traps, and expressed as transgenes in zebrafish. Expression from both transient assays and stable lines were used for analysis. Although the enhancer was active in specific nonneural cells of the notochord when placed with APPb gene promoter proximal elements its function was restricted to, and absolutely required for, specific expression in neurons when juxtaposed with additional far-upstream promoter elements of the gene. We demonstrate that expression of green fluorescent protein fluorescence resembling the tissue distribution of APPb mRNA requires both the intron 1 enhancer and similar to 28 kb of DNA upstream of the gene. The results indicate that tissue-specificity of an isolated enhancer may be quite different from that in the context of its own gene. Using this enhancer and upstream sequence, polymorphic variants of APPb can now more closely recapitulate the endogenous pattern and regulation of APPb expression in animal models for Alzheimer's disease. The methodology should help functionally map multiple noncontiguous regulatory elements in BACs with or without gene-coding sequences. JF - Nucleic Acids Research AU - Shakes, Leighcraft A AU - Malcolm, Tennison L AU - Allen, Kevin L AU - De, Supriyo AU - Harewood, Ken R AU - Chatterjee, Pradeep K AD - 1 Julius L. Chambers Biomedical/Biotechnology Research Institute, 2 Department of Chemistry, 3 Department of Biology, North Carolina Central University, Durham, NC 27707 and 4 Gene Expression and Genomics Unit, National Institute on Aging, NIH, Triad Technology Center, Baltimore, MD 21224, USA, pchatterjee@nccu.edu Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 6237 EP - 6248 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 36 IS - 19 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Nucleotide sequence KW - Alzheimer's disease KW - Animal models KW - Green fluorescent protein KW - Freshwater KW - Freshwater fish KW - Promoters KW - Chromosomes KW - Fluorescence KW - Regulatory sequences KW - Biopolymorphism KW - mRNA KW - Amyloid precursor protein KW - Bacterial artificial chromosomes KW - Danio rerio KW - Enhancers KW - Neurodegenerative diseases KW - Neurons KW - Introns KW - DNA KW - Notochord KW - Traps KW - Nucleic acids KW - J 02310:Genetics & Taxonomy KW - W 30925:Genetic Engineering KW - N3 11023:Neurogenetics KW - Q1 08484:Species interactions: parasites and diseases KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19589693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Context+dependent+function+of+APPb+enhancer+identified+using+enhancer+trap-containing+BACs+as+transgenes+in+zebrafish&rft.au=Shakes%2C+Leighcraft+A%3BMalcolm%2C+Tennison+L%3BAllen%2C+Kevin+L%3BDe%2C+Supriyo%3BHarewood%2C+Ken+R%3BChatterjee%2C+Pradeep+K&rft.aulast=Shakes&rft.aufirst=Leighcraft&rft.date=2008-11-01&rft.volume=36&rft.issue=19&rft.spage=6237&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/10.1093%2Fnar%2Fgkn628 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Promoters; Chromosomes; Neurons; Nucleotide sequence; DNA; Biopolymorphism; Freshwater fish; Nucleic acids; Fluorescence; Regulatory sequences; Alzheimer's disease; Green fluorescent protein; Animal models; Amyloid precursor protein; mRNA; Bacterial artificial chromosomes; Neurodegenerative diseases; Enhancers; Introns; Traps; Notochord; Danio rerio; Freshwater DO - http://dx.doi.org/10.1093/nar/gkn628 ER - TY - JOUR T1 - Sex Partner Type and Condom Use in African American Adolescent Mothers: A Literature Review AN - 19562244; 8783581 AB - PROBLEM:Teen mothers may need mental health counseling that goes beyond addressing the parenting stressors of motherhood to include those related to sexual risk decision-making. Sexual risk behaviors of adolescent girls are influenced by partner type. Coparent, 'baby's daddy' partner types may exert unique psychosocial influences on their sexual risk decisions and, thus, their risk for human immunodeficiency virus infection. METHODS:A review of literature was conducted to identify, critique, and summarize the research on partner-type influences on the sexual risk decision-making of African American adolescent mothers. Extensive searches of PubMed, CINAHL, MEDLINE, PsycINFO, and CRISP were conducted. Data displays were constructed to compare constructs across studies. Both the strengths and limitations of these studies are highlighted. FINDINGS:Most studies on partner types and sexual behavior are quantitative, and few target adolescent mothers. Only four studies were identified that focused on sexual partner influences on condom use in African American adolescent mothers, with only one examining the coparent as a partner type. No published studies were identified that examined adolescent mothers' reasons for making partner-specific sexual risk decisions or choices made in regard to having sex with their 'babies' daddies.' CONCLUSION:The state of the science is inadequate regarding partner-type influences on the sexual risk decisions of African American adolescent mothers. Further research is vital for mental healthcare providers so that the depth and complexity of partner-related influences on sexual risk decisions can be appropriately addressed during risk assessments and counseling. JF - Journal of Child & Adolescent Psychiatric Nursing AU - Nelson, LaRon E AU - Morrison-Beedy, Dianne AD - Monroe County Department of Public Health, Rochester, NY, and NIH/NINR Pre-Doctoral Fellow, Center for High Risk Children and Youth, University of Rochester School of Nursing, Rochester, NY, lnelson@monroecounty.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 213 EP - 219 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 21 IS - 4 SN - 1073-6077, 1073-6077 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Adolescent mothers KW - African American KW - condom use KW - decision-making KW - HIV KW - HIV prevention KW - partner type KW - review of literature KW - state of the science KW - Risk assessment KW - sexual behavior KW - Data processing KW - Adolescence KW - Infection KW - Sexual behavior KW - Medical personnel KW - Condoms KW - Sexual partners KW - Decision making KW - Mental disorders KW - Human immunodeficiency virus KW - Reviews KW - Nursing KW - condoms KW - infection KW - Africa KW - mental disorders KW - Adolescents KW - Ethnic groups KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19562244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+%26+Adolescent+Psychiatric+Nursing&rft.atitle=Sex+Partner+Type+and+Condom+Use+in+African+American+Adolescent+Mothers%3A+A+Literature+Review&rft.au=Nelson%2C+LaRon+E%3BMorrison-Beedy%2C+Dianne&rft.aulast=Nelson&rft.aufirst=LaRon&rft.date=2008-11-01&rft.volume=21&rft.issue=4&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+%26+Adolescent+Psychiatric+Nursing&rft.issn=10736077&rft_id=info:doi/10.1111%2Fj.1744-6171.2008.00140.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sexual partners; Risk assessment; Condoms; Decision making; Mental disorders; Data processing; Nursing; Reviews; Adolescence; Infection; Sexual behavior; sexual behavior; infection; condoms; mental disorders; Medical personnel; Ethnic groups; Adolescents; Human immunodeficiency virus; Africa DO - http://dx.doi.org/10.1111/j.1744-6171.2008.00140.x ER - TY - JOUR T1 - Transient Exposure to Transforming Growth Factor Beta 3 Under Serum-Free Conditions Enhances the Biomechanical and Biochemical Maturation of Tissue-Engineered Cartilage AN - 19512613; 8833721 AB - A goal of cartilage tissue engineering is the production of cell-laden constructs possessing sufficient mechanical and biochemical features to enable native tissue function. This study details a systematic characterization of a serum-free (SF) culture methodology employing transient growth factor supplementation to promote robust maturation of tissue-engineered cartilage. Bovine chondrocyte agarose hydrogel constructs were cultured under free-swelling conditions in serum-containing or SF medium supplemented continuously or transiently with varying doses of transforming growth factor beta 3 (TGF- beta 3). Constructs were harvested weekly or bi-weekly and assessed for mechanical and biochemical properties. Transient exposure (2 weeks) to low concentrations (2.5-5 ng/mL) of TGF- beta 3 in chemically defined medium facilitated robust and highly reproducible construct maturation. Constructs receiving transient TGF- beta 3 exposure achieved native tissue levels of compressive modulus (0.8 MPa) and proteoglycan content (6-7% of wet weight) after less than 2 months of in vitro culture. This maturation response was far superior to that observed after continuous growth factor supplementation or transient TGF- beta 3 treatment in the presence of serum. These findings represent a significant advance in developing an ex vivo culture methodology to promote production of clinically relevant and mechanically competent tissue-engineered cartilage constructs for implantation to repair damaged articular surfaces. JF - Tissue Engineering, Part A: Tissue Engineering AU - Byers, BA AU - Mauck, R L AU - Chiang, I E AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, 50 South Drive, Building 50, Room 1503, MSC 8022, Bethesda, MD 20892, USA, tuanr@mail.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1821 EP - 1834 VL - 14 IS - 11 SN - 1937-3341, 1937-3341 KW - Biotechnology and Bioengineering Abstracts KW - Proteoglycans KW - hydrogels KW - Cartilage KW - Chondrocytes KW - Transforming growth factor-^b KW - Cell culture KW - Tissue engineering KW - Supplementation KW - Transforming growth factor-^b1 KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19512613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.atitle=Transient+Exposure+to+Transforming+Growth+Factor+Beta+3+Under+Serum-Free+Conditions+Enhances+the+Biomechanical+and+Biochemical+Maturation+of+Tissue-Engineered+Cartilage&rft.au=Byers%2C+BA%3BMauck%2C+R+L%3BChiang%2C+I+E%3BTuan%2C+R+S&rft.aulast=Byers&rft.aufirst=BA&rft.date=2008-11-01&rft.volume=14&rft.issue=11&rft.spage=1821&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+A%3A+Tissue+Engineering&rft.issn=19373341&rft_id=info:doi/10.1089%2Ften.tea.2007.0222 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tissue engineering; Transforming growth factor-^b; Cartilage; Cell culture; Transforming growth factor-^b1; Supplementation; Proteoglycans; Chondrocytes; hydrogels DO - http://dx.doi.org/10.1089/ten.tea.2007.0222 ER - TY - JOUR T1 - Age-Dependent Demise of GNAS-Mutated Skeletal Stem Cells and "Normalization" of Fibrous Dysplasia of Bone AN - 19492974; 8614008 AB - We studied the role of somatic mosaicism in fibrous dysplasia of bone (FD) within the context of skeletal ("mesenchymal") stem cells by assessing the frequency of mutated colony forming unit-fibroblasts (CFU-Fs) from FD lesions, and in some cases, from unaffected sites, in a series of patients. There was a tight inverse correlation between the percentage mutant CFU-F versus age, suggesting demise of mutant stem cells caused by exuberant apoptosis noted in samples from young patients. In older patients, either partially or completely normal bone/marrow histology was observed. On in vivo transplantation, FD ossicles were generated only by cell strains in which mutant CFU-Fs were identified. Strains that lacked mutant CFU-F (but were mutation positive) failed to regenerate an FD ossicle. These data indicate that GNAS mutations are only pathogenic when in clonogenic skeletal stem cells. From these data, we have evolved the novel concept of "normalization" of FD. As a lesion ages, mutant stem cells fail to self-renew, and their progeny are consumed by apoptosis, whereas residual normal stem cells survive, self-renew, and enable formation of a normal structure. This suggests that activating GNAS mutations disrupt a pathway that is required for skeletal stem cell self-renewal. JF - Journal of Bone and Mineral Research AU - Kuznetsov, SA AU - Cherman, N AU - Riminucci, M AU - Collins, M T AU - Robey, P G AU - Bianco, P AD - CSDB/NIDCR/NIH/DHHS, 30 Convent Drive, MSC 4320, Building 30, Room 228, Bethesda, MD 20892, USA, probey@dir.nidcr.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1731 EP - 1740 VL - 23 IS - 11 SN - 0884-0431, 0884-0431 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Age KW - Data processing KW - Apoptosis KW - Bone marrow KW - Bone dysplasia KW - Fibrous dysplasia KW - Stem cells KW - Colonies KW - Mosaicism KW - Progeny KW - Mesenchyme KW - Mutation KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19492974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bone+and+Mineral+Research&rft.atitle=Age-Dependent+Demise+of+GNAS-Mutated+Skeletal+Stem+Cells+and+%22Normalization%22+of+Fibrous+Dysplasia+of+Bone&rft.au=Kuznetsov%2C+SA%3BCherman%2C+N%3BRiminucci%2C+M%3BCollins%2C+M+T%3BRobey%2C+P+G%3BBianco%2C+P&rft.aulast=Kuznetsov&rft.aufirst=SA&rft.date=2008-11-01&rft.volume=23&rft.issue=11&rft.spage=1731&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/10.1359%2FJBMR.080609 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Colonies; Age; Stem cells; Apoptosis; Data processing; Mosaicism; Bone marrow; Progeny; Mesenchyme; Bone dysplasia; Mutation; Fibrous dysplasia DO - http://dx.doi.org/10.1359/JBMR.080609 ER - TY - JOUR T1 - DNA cleavage assay for the identification of topoisomerase I inhibitors AN - 19412348; 8758429 AB - The inhibition of DNA topoisomerase I (Top1) has proven to be a successful approach in the design of anticancer agents. However, despite the clinical successes of the camptothecin derivatives, a significant need for less toxic and more chemically stable Top1 inhibitors still persists. Here, we describe one of the most frequently used protocols to identify novel Top1 inhibitors. These methods use uniquely 3'-radiolabeled DNA substrates and denaturing polyacrylamide gel electrophoresis to provide evidence for the Top1-mediated DNA cleaving activity of potential Top1 inhibitors. These assays allow comparison of the effectiveness of different drugs in stabilizing the Top1-DNA intermediate or cleavage (cleavable) complex. A variation on these assays is also presented, which provides a suitable system for determining whether the inhibitor blocks the forward cleavage or religation reactions by measuring the reversibility of the drug-induced Top1- DNA cleavage complexes. This entire protocol can be completed in [math]2 d. JF - Nature Protocols AU - Dexheimer, Thomas S AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., pommier@nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1736 EP - 1750 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 11 SN - 1754-2189, 1754-2189 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genetic analysis KW - Pharmacology and toxicology KW - DNA KW - DNA topoisomerase KW - Antitumor agents KW - Drugs KW - Gel electrophoresis KW - Camptothecin KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19412348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=DNA+cleavage+assay+for+the+identification+of+topoisomerase+I+inhibitors&rft.au=Dexheimer%2C+Thomas+S%3BPommier%2C+Yves&rft.aulast=Dexheimer&rft.aufirst=Thomas&rft.date=2008-11-01&rft.volume=3&rft.issue=11&rft.spage=1736&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.174 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA topoisomerase; DNA; Drugs; Antitumor agents; Camptothecin; Gel electrophoresis DO - http://dx.doi.org/10.1038/nprot.2008.174 ER - TY - JOUR T1 - Reverse-phase protein lysate microarrays for cell signaling analysis AN - 19411048; 8758434 AB - 'Reverse-phase' protein lysate microarray (RPA) assays use micro-scale, cell lysate dot blots that are printed to a substrate, followed by quantitative immunochemical protein detection, known to be particularly effective across many samples. Large-scale sample collection is a labor- intensive and time-consuming process; the information yielded from RPA assays, however, provides unique opportunities to experimentally interpret theoretical protein networks quantitatively. When specific antibodies are used, RPA can generate 1,000 times more data points using 10,000 times less sample volume than an ordinary western blot, enabling researchers to monitor quantitative proteomic responses for various time-scale and input-dose gradients simultaneously. Hence, the RPA system can be an excellent method for experimental validation of theoretical protein network models. Besides the initial screening of primary antibodies, collection of several hundreds of sample lysates from 1- to 8-h periods can be completed in [math]10 d; subsequent RPA printing and signal detection steps require an additional 2-3 d. JF - Nature Protocols AU - Spurrier, Brett AU - Ramalingam, Sundhar AU - Nishizuka, Satoshi AD - Molecular Translational Technology Section, Molecular Therapeutics Program, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA., snishizu@iwate-med.ac.jp Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 1796 EP - 1808 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 11 SN - 1754-2189, 1754-2189 KW - Biotechnology and Bioengineering Abstracts KW - Biochemistry and protein analysis KW - Cell and developmental biology KW - Immunological techniques KW - Western blotting KW - Antibodies KW - Data processing KW - Printing KW - Information processing KW - Protein arrays KW - proteomics KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19411048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Reverse-phase+protein+lysate+microarrays+for+cell+signaling+analysis&rft.au=Spurrier%2C+Brett%3BRamalingam%2C+Sundhar%3BNishizuka%2C+Satoshi&rft.aulast=Spurrier&rft.aufirst=Brett&rft.date=2008-11-01&rft.volume=3&rft.issue=11&rft.spage=1796&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2008.179 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Western blotting; Antibodies; Printing; Data processing; Information processing; Protein arrays; proteomics; Signal transduction DO - http://dx.doi.org/10.1038/nprot.2008.179 ER - TY - JOUR T1 - Comparison of gestational age at birth based on last menstrual period and ultrasound during the first trimester AN - 19332684; 8647980 AB - Reported last menstrual period (LMP) is commonly used to estimate gestational age (GA) but may be unreliable. Ultrasound in the first trimester is generally considered a highly accurate method of pregnancy dating. The authors compared first trimester report of LMP and first trimester ultrasound for estimating GA at birth and examined whether disagreement between estimates varied by maternal and infant characteristics. Analyses included 1867 singleton livebirths to women enrolled in a prospective pregnancy cohort. The authors computed the difference between LMP and ultrasound GA estimates (GA difference) and examined the proportion of births within categories of GA difference stratified by maternal and infant characteristics. The proportion of births classified as preterm, term and post-term by pregnancy dating methods was also examined.LMP-based estimates were 0.8 days (standard deviation=8.0, median=0) longer on average than ultrasound estimates. LMP classified more births as post-term than ultrasound (4.0% vs. 0.7%). GA difference was greater among young women, non-Hispanic Black and Hispanic women, women of non-optimal body weight and mothers of low-birthweight infants. Results indicate first trimester report of LMP reasonably approximates gestational age obtained from first trimester ultrasound, but the degree of discrepancy between estimates varies by important maternal characteristics. JF - Paediatric and Perinatal Epidemiology AU - Hoffman, Caroline S AU - Messer, Lynne C AU - Mendola, Pauline AU - Savitz, David A AU - Herring, Amy H AU - Hartmann, Katherine E AD - Department of Epidemiology,, dilworthch@niehs.nih.gov Y1 - 2008/11// PY - 2008 DA - Nov 2008 SP - 587 EP - 596 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 22 IS - 6 SN - 0269-5022, 0269-5022 KW - Biotechnology and Bioengineering Abstracts KW - gestational age KW - measurement KW - accuracy KW - LMP KW - ultrasound estimates KW - maternal age KW - ethnic group KW - preterm KW - post-term KW - bias KW - Birth KW - Gestational age KW - Body weight KW - Dating KW - Menstruation KW - Ultrasound KW - Pregnancy KW - Infants KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19332684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paediatric+and+Perinatal+Epidemiology&rft.atitle=Comparison+of+gestational+age+at+birth+based+on+last+menstrual+period+and+ultrasound+during+the+first+trimester&rft.au=Hoffman%2C+Caroline+S%3BMesser%2C+Lynne+C%3BMendola%2C+Pauline%3BSavitz%2C+David+A%3BHerring%2C+Amy+H%3BHartmann%2C+Katherine+E&rft.aulast=Hoffman&rft.aufirst=Caroline&rft.date=2008-11-01&rft.volume=22&rft.issue=6&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Paediatric+and+Perinatal+Epidemiology&rft.issn=02695022&rft_id=info:doi/10.1111%2Fj.1365-3016.2008.00965.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Birth; Gestational age; Body weight; Dating; Menstruation; Ultrasound; Infants; Pregnancy DO - http://dx.doi.org/10.1111/j.1365-3016.2008.00965.x ER -