TY - CPAPER T1 - Identification of an essential function for the amino-terminal domain of type II keratin intermediate filament chains AN - 42267498; 3170458 AU - Steinert, P M AU - Marekov, L N AU - Candi, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42267498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+an+essential+function+for+the+amino-terminal+domain+of+type+II+keratin+intermediate+filament+chains&rft.au=Steinert%2C+P+M%3BMarekov%2C+L+N%3BCandi%2C+E&rft.aulast=Steinert&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science Publishing Co., 655 Avenue of the Americas, New York, NY 10010, Abstracts available. Paper No. 228 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a keratinocyte-specific silencer element in the proximal promoter region of the human profilaggrin gene AN - 42264287; 3170661 AU - Jang, S-I AU - Steinert, P M AU - Markova, NG Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42264287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+a+keratinocyte-specific+silencer+element+in+the+proximal+promoter+region+of+the+human+profilaggrin+gene&rft.au=Jang%2C+S-I%3BSteinert%2C+P+M%3BMarkova%2C+NG&rft.aulast=Jang&rft.aufirst=S-I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science Publishing Co., 655 Avenue of the Americas, New York, NY 10010, Abstracts available. Poster Paper No. 432 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assay to distinguish the expression of the normal and mutant allele of keratin 10 in cells derived from a patient with epidermolytic hyperkeratosis AN - 42262921; 3170662 AU - Chipev, C C AU - Woodworth, C D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42262921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Assay+to+distinguish+the+expression+of+the+normal+and+mutant+allele+of+keratin+10+in+cells+derived+from+a+patient+with+epidermolytic+hyperkeratosis&rft.au=Chipev%2C+C+C%3BWoodworth%2C+C+D&rft.aulast=Chipev&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science Publishing Co., 655 Avenue of the Americas, New York, NY 10010, Abstracts available. Poster Paper No. 433 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo modulation of E-cadherin on Langerhans cells by contact allergens and proinflammatory cytokines AN - 42258280; 3170306 AU - Schwarzenberger, K AU - Udey, M C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42258280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3A&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Psychoanalysis&rft.atitle=Editor%27s+introduction&rft.au=Wyman%2C+Herbert+M.%3BRittenberg%2C+Stephen+M.&rft.aulast=Wyman&rft.aufirst=Herbert&rft.date=2001-07-01&rft.volume=10&rft.issue=3-4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Psychoanalysis&rft.issn=1076044X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science Publishing Co., 655 Avenue of the Americas, New York, NY 10010, Abstracts available. Paper No. 75 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Soluble transglutaminase activity of keratinocytes is due to highly-processed forms of the transglutaminase 1 system AN - 42257854; 3170273 AU - Kim, S-Y AU - Chung, S-I AU - Steinert, P M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42257854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Soluble+transglutaminase+activity+of+keratinocytes+is+due+to+highly-processed+forms+of+the+transglutaminase+1+system&rft.au=Kim%2C+S-Y%3BChung%2C+S-I%3BSteinert%2C+P+M&rft.aulast=Kim&rft.aufirst=S-Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science Publishing Co., 655 Avenue of the Americas, New York, NY 10010, Abstracts available. Paper No. 42 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Women and depression AN - 42253969; 3167044 AU - Blumenthal, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42253969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Women+and+depression&rft.au=Blumenthal%2C+S+J&rft.aulast=Blumenthal&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Psychiatric Association, 1400 K Street, NW, Washington, DC 20005, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction to signal transduction AN - 42237823; 3141845 AU - Putney, JW Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42237823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Introduction+to+signal+transduction&rft.au=Putney%2C+JW+Jr&rft.aulast=Putney&rft.aufirst=JW&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Paper No. 239 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of hepatic drug metabolizing enzymes after nalidixic acid dosed feed treatment in rats and mice AN - 42231137; 3142210 AU - Dudley, C N AU - Burka, L T AU - Griffin, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42231137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Activity+of+hepatic+drug+metabolizing+enzymes+after+nalidixic+acid+dosed+feed+treatment+in+rats+and+mice&rft.au=Dudley%2C+C+N%3BBurka%2C+L+T%3BGriffin%2C+R+J&rft.aulast=Dudley&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 598 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo mutant frequency of LACI in liver DNA of transgenic mice following dietary exposure to the carcinogen-noncarcinogen pair 2,4- and 2,6-diaminotoluene AN - 42230786; 3141901 AU - Cunningham, M L AU - Hayward, J J AU - Shane, B S AU - Tindall, K R AU - Matthews, H B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42230786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vivo+mutant+frequency+of+LACI+in+liver+DNA+of+transgenic+mice+following+dietary+exposure+to+the+carcinogen-noncarcinogen+pair+2%2C4-+and+2%2C6-diaminotoluene&rft.au=Cunningham%2C+M+L%3BHayward%2C+J+J%3BShane%2C+B+S%3BTindall%2C+K+R%3BMatthews%2C+H+B&rft.aulast=Cunningham&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 290 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokines and growth factors in arsenic carcinogenicity AN - 42229573; 3142175 AU - Germolec AU - Wilmer, J L AU - Yoshida, T AU - Spalding, J AU - Simeonova, P P AU - Kayama, F AU - Gaido, K AU - Dong, W AU - Lange, R W AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42229573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytokines+and+growth+factors+in+arsenic+carcinogenicity&rft.au=Germolec%3BWilmer%2C+J+L%3BYoshida%2C+T%3BSpalding%2C+J%3BSimeonova%2C+P+P%3BKayama%2C+F%3BGaido%2C+K%3BDong%2C+W%3BLange%2C+R+W%3BLuster%2C+MI&rft.aulast=Germolec&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 563a N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Delayed induction of pulmonary CYP2B in mice after coadministration of nitrosodimethylamine (NDMA) and ethanol AN - 42229530; 3142229 AU - Kim, YE AU - Fornwald, L W AU - Anderson, L M AU - Beebe, LE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42229530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Delayed+induction+of+pulmonary+CYP2B+in+mice+after+coadministration+of+nitrosodimethylamine+%28NDMA%29+and+ethanol&rft.au=Kim%2C+YE%3BFornwald%2C+L+W%3BAnderson%2C+L+M%3BBeebe%2C+LE&rft.aulast=Kim&rft.aufirst=YE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 617 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicokinetics of the flame retardant 2,2-bis(bromomethyl)-1,3-propanediol in rats and mice AN - 42228231; 3142615 AU - Sanders, J M AU - Salemme, J AU - Burka, L T AU - Hunter, C D AU - Matthews, H B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42228231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Toxicokinetics+of+the+flame+retardant+2%2C2-bis%28bromomethyl%29-1%2C3-propanediol+in+rats+and+mice&rft.au=Sanders%2C+J+M%3BSalemme%2C+J%3BBurka%2C+L+T%3BHunter%2C+C+D%3BMatthews%2C+H+B&rft.aulast=Sanders&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 993 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Responsiveness of the human ovarian carcinoma cell line, BG-1 to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) AN - 42227949; 3141957 AU - Clark, G C AU - Rushin, G AU - Pimentel, ME Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42227949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Responsiveness+of+the+human+ovarian+carcinoma+cell+line%2C+BG-1+to+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+%28TCDD%29&rft.au=Clark%2C+G+C%3BRushin%2C+G%3BPimentel%2C+ME&rft.aulast=Clark&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 346 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Covalent modification of rat liver dipeptidyl peptidase IV by ACYL glucuronide metabolites of diclofenac AN - 42225929; 3142443 AU - Hargus, S J AU - Martin, B M AU - Pohl, L R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42225929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Covalent+modification+of+rat+liver+dipeptidyl+peptidase+IV+by+ACYL+glucuronide+metabolites+of+diclofenac&rft.au=Hargus%2C+S+J%3BMartin%2C+B+M%3BPohl%2C+L+R&rft.aulast=Hargus&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 820 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional analysis of total RNA and DNA content in the rodent brain following Pb exposure AN - 42224909; 3142404 AU - Zawia, N H AU - Bartenbach, MJ AU - Harry, G J AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42224909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regional+analysis+of+total+RNA+and+DNA+content+in+the+rodent+brain+following+Pb+exposure&rft.au=Zawia%2C+N+H%3BBartenbach%2C+MJ%3BHarry%2C+G+J%3BLuster%2C+MI&rft.aulast=Zawia&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332. Phone: (703)438-3115; Fax: (703)438-3113; Email 73162.506ompuserve, Abstracts available. Price $38. Poster Paper No. 791 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mode of toxicity of a cationic polymer to rainbow trout (Oncorhynchus mykiss) AN - 42201767; 3139905 AU - Kosteretz, K G AU - Friedman, MA AU - Lech, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42201767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mode+of+toxicity+of+a+cationic+polymer+to+rainbow+trout+%28Oncorhynchus+mykiss%29&rft.au=Kosteretz%2C+K+G%3BFriedman%2C+MA%3BLech%2C+J+J&rft.aulast=Kosteretz&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Environmental Toxicology and Chemistry, 1010 North 12th Ave., Pensacola, FL 32501-3307, USA, Abstracts available. Price $30 (includes shipping). Paper No. 435 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prospects for development of a vaccine for prevention of hepatitis E AN - 42185477; 3123173 AU - Purcell, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42185477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prospects+for+development+of+a+vaccine+for+prevention+of+hepatitis+E&rft.au=Purcell%2C+R&rft.aulast=Purcell&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Books International, PO Box 605, Herndon, VA 22070, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel mutations in the gyrB gene of Borrelia burgdorferi confer resistance to coumarin antimicrobial agents AN - 42184274; 3122670 AU - Samuels, D S AU - Huang, WM AU - Garon, C F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42184274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Novel+mutations+in+the+gyrB+gene+of+Borrelia+burgdorferi+confer+resistance+to+coumarin+antimicrobial+agents&rft.au=Samuels%2C+D+S%3BHuang%2C+WM%3BGaron%2C+C+F&rft.aulast=Samuels&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Books International, PO Box 605, Herndon, VA 22070, Abstracts available. Price $25. Paper No. C89 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pilot study of the safety and antiviral activity of a chimeric anti-tumor necrosis factor antibody in HIV-infected patients AN - 42181612; 3122387 AU - Walker, R E AU - Kelly, G G AU - Kilgariff, CE AU - Woody, J N AU - Falloon, J AU - Polis, MA AU - Davey, R T AU - Kovacs, JA AU - Masur, H AU - Lane, H C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42181612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pilot+study+of+the+safety+and+antiviral+activity+of+a+chimeric+anti-tumor+necrosis+factor+antibody+in+HIV-infected+patients&rft.au=Walker%2C+R+E%3BKelly%2C+G+G%3BKilgariff%2C+CE%3BWoody%2C+J+N%3BFalloon%2C+J%3BPolis%2C+MA%3BDavey%2C+R+T%3BKovacs%2C+JA%3BMasur%2C+H%3BLane%2C+H+C&rft.aulast=Walker&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Books International, PO Box 605, Herndon, VA 22070, Abstracts available. Price $25. Poster Paper No. I30 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - OCD and developmental disabilities AN - 42021666; 3098276 AU - Swedo, SE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42021666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=OCD+and+developmental+disabilities&rft.au=Swedo%2C+SE&rft.aulast=Swedo&rft.aufirst=SE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Psychiatric Association, 1400 K St., NW, Washington, DC 20005, Abstracts. Paper No. 12E N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Managing OCD in children and adolescents AN - 42019994; 3098244 AU - Rapoport, J L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42019994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Managing+OCD+in+children+and+adolescents&rft.au=Rapoport%2C+J+L&rft.aulast=Rapoport&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Psychiatric Association, 1400 K St., NW, Washington, DC 20005, Abstracts. Paper No. 6B N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sickling of cultured erythroblasts from sickle cell disease patients AN - 42019157; 3093241 AU - Hasegawa, S AU - Rodgers, G P AU - Noguchi, C T AU - Uyesaka, N AU - Schechter, AN AU - Fibach, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42019157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sickling+of+cultured+erythroblasts+from+sickle+cell+disease+patients&rft.au=Hasegawa%2C+S%3BRodgers%2C+G+P%3BNoguchi%2C+C+T%3BUyesaka%2C+N%3BSchechter%2C+AN%3BFibach%2C+E&rft.aulast=Hasegawa&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Guillermo Ruiz-Reyes, MD, Laboratorios Clinicos de Puebla, Blvd Diaz Ordaz, 808 Anzures, Puebla, Pue 72530, Mexico. Poster Paper No. 207 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain local functional activity: Metabolic mapping AN - 42017272; 3097728 AU - Sokoloff, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42017272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Brain+local+functional+activity%3A+Metabolic+mapping&rft.au=Sokoloff%2C+L&rft.aulast=Sokoloff&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Psychiatric Association, 1400 K St., NW, Washington, DC 20005, Abstracts. Paper No. 27F N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Population pharmacokinetics (PKs) of IV & oral ondansetron in patients with systemic lupus erythematosus (SLE) AN - 42010912; 3083200 AU - Amantea, MA AU - Yarboro, C AU - Forrest, A AU - Pucino, F AU - Klippel, J H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42010912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Occupational+and+leisure+noise+exposures+as+risk+factors+for+adult+hearing+impairment%3A+The+Nord+Trondelag+%28NT%29+Hearing+Study&rft.au=Hoffman%2C+HJ%3BMacTurk%2C+R+H%3BReed%2C+G+W%3BTambs%2C+K%3BHolmen%2C+J%3BBorchgrevink%2C+H+M&rft.aulast=Hoffman&rft.aufirst=HJ&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacolgy and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Poster Paper No. PII-33 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alteration of a potential endoplasmic reticulum retention sequence, RDEL, in the A subunit of Escherichia coli heat-labile enterotoxin fails to abrogate cytotonic activity AN - 42006965; 3100576 AU - Cieplak, W Jr AU - Messer, R J AU - Konkel, ME AU - Grant, CCR Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42006965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Alteration+of+a+potential+endoplasmic+reticulum+retention+sequence%2C+RDEL%2C+in+the+A+subunit+of+Escherichia+coli+heat-labile+enterotoxin+fails+to+abrogate+cytotonic+activity&rft.au=Cieplak%2C+W+Jr%3BMesser%2C+R+J%3BKonkel%2C+ME%3BGrant%2C+CCR&rft.aulast=Cieplak&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. B24 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of the serotonin agonist metachlorophenylpiperazine on cerebral metabolism in alcoholics and normal volunteers AN - 42006545; 3083100 AU - Andreason, P J AU - George, D T AU - Geyer, CL AU - Szymanski, H AU - Rio, D AU - Momenan, R AU - Zametkin, AJ AU - Eckardt, M AU - Hommer, D AU - Linnoila, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42006545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+the+serotonin+agonist+metachlorophenylpiperazine+on+cerebral+metabolism+in+alcoholics+and+normal+volunteers&rft.au=Andreason%2C+P+J%3BGeorge%2C+D+T%3BGeyer%2C+CL%3BSzymanski%2C+H%3BRio%2C+D%3BMomenan%2C+R%3BZametkin%2C+AJ%3BEckardt%2C+M%3BHommer%2C+D%3BLinnoila%2C+M&rft.aulast=Andreason&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacolgy and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800, USA. Poster Paper No. PI-52 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytochrome P450 and glutathione levels in mouse liver during benzodiazepine-induced cell proliferation AN - 42003527; 3086025 AU - Griffin, R J AU - Dudley, C N AU - Burka, L T AU - Cunningham, M L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42003527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytochrome+P450+and+glutathione+levels+in+mouse+liver+during+benzodiazepine-induced+cell+proliferation&rft.au=Griffin%2C+R+J%3BDudley%2C+C+N%3BBurka%2C+L+T%3BCunningham%2C+M+L&rft.aulast=Griffin&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332, USA, Price $38.. Poster Paper No. 94 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a protein produced by Chlamydia psittaci which is localized to the inclusion membrane of infected cells AN - 42000864; 3100615 AU - Rockey, D D AU - Heinzen, R A AU - Hackstadt, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42000864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+a+protein+produced+by+Chlamydia+psittaci+which+is+localized+to+the+inclusion+membrane+of+infected+cells&rft.au=Rockey%2C+D+D%3BHeinzen%2C+R+A%3BHackstadt%2C+T&rft.aulast=Rockey&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Microbiology, 1325 Massachusetts Ave., NW, Washington, DC 20005, Abstracts. Poster Paper No. D18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spermatocyte toxicity of 2-methoxyethanol (ME) in vivo and in vitro: Requirement for an intact seminiferous tubule structure for germ cell degeneration AN - 41994656; 3086195 AU - Ku, W W AU - Chapin, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41994656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Spermatocyte+toxicity+of+2-methoxyethanol+%28ME%29+in+vivo+and+in+vitro%3A+Requirement+for+an+intact+seminiferous+tubule+structure+for+germ+cell+degeneration&rft.au=Ku%2C+W+W%3BChapin%2C+R+E&rft.aulast=Ku&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 22090-5332, USA, Price $38.. Poster Paper No. 264 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rabies virus anti-nucleoprotein antibody is protective and has low level neutralizing activity AN - 41973277; 3041888 AU - Lodmell, D L AU - Esposito, J J AU - Ewalt, L C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41973277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rabies+virus+anti-nucleoprotein+antibody+is+protective+and+has+low+level+neutralizing+activity&rft.au=Lodmell%2C+D+L%3BEsposito%2C+J+J%3BEwalt%2C+L+C&rft.aulast=Lodmell&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Virology, Abstracts Paper No. 1-5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human interleukin-2 receptor: From adult T-cell leukemia to X-linked severe combined immunodeficiency AN - 41956263; 3073026 AU - Leonard, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41956263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+interleukin-2+receptor%3A+From+adult+T-cell+leukemia+to+X-linked+severe+combined+immunodeficiency&rft.au=Leonard%2C+W&rft.aulast=Leonard&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The American Society of Hematology, 1101 Connecticut Ave., NW, Suite 700, Washington, DC 20036, Abstracts $30. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current practice of screening mammography in the U.S.: Data from the national survey of mammography facilities AN - 41951977; 3062598 AU - Houn, F AU - Brown, M L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41951977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Current+practice+of+screening+mammography+in+the+U.S.%3A+Data+from+the+national+survey+of+mammography+facilities&rft.au=Houn%2C+F%3BBrown%2C+M+L&rft.aulast=Houn&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: CTRC8122 Datapoint Dr., Suite 600, San Antonio, TX 78229, Proceedings Poster Paper No. 163 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Administration of ATP leads to improved weight gain in CFTR knockout mice AN - 41931849; 3055931 AU - Abraham, E H AU - Okunieff, P AU - Kahn, J AU - Zaidi, ST AU - Efird, J T AU - Khaw, K T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41931849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Administration+of+ATP+leads+to+improved+weight+gain+in+CFTR+knockout+mice&rft.au=Abraham%2C+E+H%3BOkunieff%2C+P%3BKahn%2C+J%3BZaidi%2C+ST%3BEfird%2C+J+T%3BKhaw%2C+K+T&rft.aulast=Abraham&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department9th Floor, 605 Third Avenue, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Pediatric Pulmonology, Supplement 9, September 1993, ISSN: 8755-6863 Poster Paper No. 174 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adhesion of resident epidermal leukocytes to keratinocytes (KC) mediated by E-cadherin (E-cad) AN - 41931638; 3049296 AU - Udey, M C AU - Tang, A AU - Amagai, M AU - Stanley, J R AU - Lee, M G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41931638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Adhesion+of+resident+epidermal+leukocytes+to+keratinocytes+%28KC%29+mediated+by+E-cadherin+%28E-cad%29&rft.au=Udey%2C+M+C%3BTang%2C+A%3BAmagai%2C+M%3BStanley%2C+J+R%3BLee%2C+M+G&rft.aulast=Udey&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 1625 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclosporin A suppresses HIV-1 infection in primary T lymphocytes acutely infected in vitro AN - 41931199; 3048690 AU - Vaccarezza, M AU - Pantaleo, G AU - Cohen, O J AU - Hohman, R H AU - Fauci, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41931199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cyclosporin+A+suppresses+HIV-1+infection+in+primary+T+lymphocytes+acutely+infected+in+vitro&rft.au=Vaccarezza%2C+M%3BPantaleo%2C+G%3BCohen%2C+O+J%3BHohman%2C+R+H%3BFauci%2C+A+S&rft.aulast=Vaccarezza&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 1019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Partial sequence comparison of eight new Chinese HEV strains suggests the genome sequence is relatively stable AN - 41930210; 3042005 AU - Yin, S AU - Tsarev, SA AU - Purcell, R H AU - Emerson, SU Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41930210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Partial+sequence+comparison+of+eight+new+Chinese+HEV+strains+suggests+the+genome+sequence+is+relatively+stable&rft.au=Yin%2C+S%3BTsarev%2C+SA%3BPurcell%2C+R+H%3BEmerson%2C+SU&rft.aulast=Yin&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Virology, Abstracts Paper No. 13-7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous peptides bound to class I MHC molecules AN - 41923453; 3048132 AU - DiBrino, M AU - Parker, K C AU - Biddison, W AU - Coligan, JE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41923453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Endogenous+peptides+bound+to+class+I+MHC+molecules&rft.au=DiBrino%2C+M%3BParker%2C+K+C%3BBiddison%2C+W%3BColigan%2C+JE&rft.aulast=DiBrino&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 461 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA gyrase in coumarin-resistant Borrelia burgdorferi , the Lyme disease agent AN - 41917238; 2997634 AU - Samuels, D S AU - Huang, Wai Mun AU - Marconi, R T AU - Garon, C F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:MULTIDISCIPLINARY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41917238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=DNA+gyrase+in+coumarin-resistant+Borrelia+burgdorferi+%2C+the+Lyme+disease+agent&rft.au=Samuels%2C+D+S%3BHuang%2C+Wai+Mun%3BMarconi%2C+R+T%3BGaron%2C+C+F&rft.aulast=Samuels&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Pacific Division AAAS PublicationsHerpetology Dept., California Academy of Sciences, San Francisco, CA 94118, USA, Proceedings - Program with Abstracts, $5.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New strategy for development of safe and effective rotavirus vaccine candidates AN - 41917153; 3042406 AU - Hoshino, Y AU - Saif, L J AU - Kang, S-Y AU - Sereno, M M AU - Kapikian, A Z Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41917153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+strategy+for+development+of+safe+and+effective+rotavirus+vaccine+candidates&rft.au=Hoshino%2C+Y%3BSaif%2C+L+J%3BKang%2C+S-Y%3BSereno%2C+M+M%3BKapikian%2C+A+Z&rft.aulast=Hoshino&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Virology, Abstracts Paper No. 56-8 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of damper circuits in field orientated synchronous drives AN - 41913618; 3009458 AU - Brass, MA AU - Mecrow, B C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING KW - U 3000:CIVIL AND MECHANICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41913618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+damper+circuits+in+field+orientated+synchronous+drives&rft.au=Brass%2C+MA%3BMecrow%2C+B+C&rft.aulast=Brass&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Conference Services, IEESavoy Place, London WC2R 0BL, UK; Telephone: 071-344 5477; Fax: 071-497 3633; Telex: 261176 IEE LDN G, Proceedings N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of oncogenes on transforming growth factor- beta regulation of leukemic cell growth and differentiation AN - 41912734; 3030625 AU - Ruscetti, F AU - Birchenall-Roberts, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41912734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+oncogenes+on+transforming+growth+factor-+beta+regulation+of+leukemic+cell+growth+and+differentiation&rft.au=Ruscetti%2C+F%3BBirchenall-Roberts%2C+M&rft.aulast=Ruscetti&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Dr. Mark A. Wainberg, McGill Univ. AIDS Centre, Jewish General Hosp.3755 Cote Ste-Catherine, Montreal, PQ, Canada; Telephone: 514/340-8260; Fax: 514/340-7537, Abstracts Paper No. 15 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ion channel structures in the nucleotide binding fold domains of the cystic fibrosis transmembrane regulator AN - 41910662; 3055743 AU - Pollard, H B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41910662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ion+channel+structures+in+the+nucleotide+binding+fold+domains+of+the+cystic+fibrosis+transmembrane+regulator&rft.au=Pollard%2C+H+B&rft.aulast=Pollard&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department9th Floor, 605 Third Avenue, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Pediatric Pulmonology, Supplement 9, September 1993, ISSN: 8755-6863 Paper No. S15.2 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development and antigen specificity of CD8 super(+) cytotoxic T-lymphocytes in beta 2-microglobulin negative, MHC class I-deficient mice in response to immunization with tumor cells AN - 41907075; 3048752 AU - Apasov, S G AU - Sitkovsky, M V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41907075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Development+and+antigen+specificity+of+CD8+super%28%2B%29+cytotoxic+T-lymphocytes+in+beta+2-microglobulin+negative%2C+MHC+class+I-deficient+mice+in+response+to+immunization+with+tumor+cells&rft.au=Apasov%2C+S+G%3BSitkovsky%2C+M+V&rft.aulast=Apasov&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 1081 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Picolinic acid and interferon- gamma synergistically induce nitric oxide synthase mRNA expression in murine macrophages AN - 41899513; 3047967 AU - Melillo, G AU - Cox, G W AU - Biragyn, A AU - Sheffler, LA AU - Varesio, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41899513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Picolinic+acid+and+interferon-+gamma+synergistically+induce+nitric+oxide+synthase+mRNA+expression+in+murine+macrophages&rft.au=Melillo%2C+G%3BCox%2C+G+W%3BBiragyn%2C+A%3BSheffler%2C+LA%3BVaresio%2C+L&rft.aulast=Melillo&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 296 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Splenic B cells from maids mice show a selective defect in tyrosine phosphorylation in response to IGM cross-linking AN - 41892744; 3049183 AU - Selvey, LA AU - Morse, HC III AU - June, CH AU - Hodes, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41892744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Splenic+B+cells+from+maids+mice+show+a+selective+defect+in+tyrosine+phosphorylation+in+response+to+IGM+cross-linking&rft.au=Selvey%2C+LA%3BMorse%2C+HC+III%3BJune%2C+CH%3BHodes%2C+R+J&rft.aulast=Selvey&rft.aufirst=LA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=01718630&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association of Immunologists428 East Preston Street, Baltimore, MD 21202, USA, Abstracts, Journal of Immunology, ISSN: 002-1767, Volume 150/Number 8/Part II/April 15, 1993 Paper No. 1512 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Replication of UV-irradiated, double-stranded DNA in vitro AN - 41889714; 2933755 AU - Kunkel, T A AU - Thomas, D C AU - Minnick, D T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41889714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Replication+of+UV-irradiated%2C+double-stranded+DNA+in+vitro&rft.au=Kunkel%2C+T+A%3BThomas%2C+D+C%3BMinnick%2C+D+T&rft.aulast=Kunkel&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 9th Floor, 605 Third Avenue, New York, NY 10158, USA; Telephone: (212) 850-6543, Abstracts, Environmental and Molecular Mutagenesis, Volume 21, Supplement 22, 1993, ISSN: 0893-6692 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV infection is active and progressive in lymphoid tissue during the prolonged period of clinical latency AN - 41878304; 3010098 AU - Pantaleo, G AU - Graziosi, C AU - Demarest, J F AU - Butini, L AU - Cohen, O J AU - Fauci, AL Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41878304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HIV+infection+is+active+and+progressive+in+lymphoid+tissue+during+the+prolonged+period+of+clinical+latency&rft.au=Pantaleo%2C+G%3BGraziosi%2C+C%3BDemarest%2C+J+F%3BButini%2C+L%3BCohen%2C+O+J%3BFauci%2C+AL&rft.aulast=Pantaleo&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Pulsus Group2902 S. Sheridan Way, Oakville, ON L6J 7L6, Canada; Telephone: (416) 829-4770; Fax: (416) 829-4799, Abstracts, The Canadian Journal of Infectious Diseases, Volume 4 Supplement B May 1993, ISSN: 1180-2332 Paper No. KB-01 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD8 super(+) trends in HIV-infected children in a trial of intravenous immunoglobulin (IG): Possible bearing on immunopathogenesis of more rapid disease progression in children than adults AN - 41876344; 2940700 AU - Mofenson, L M AU - Moye, J AU - Bethel, J AU - Flyer, P AU - Nugent, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41876344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=CD8+super%28%2B%29+trends+in+HIV-infected+children+in+a+trial+of+intravenous+immunoglobulin+%28IG%29%3A+Possible+bearing+on+immunopathogenesis+of+more+rapid+disease+progression+in+children+than+adults&rft.au=Mofenson%2C+L+M%3BMoye%2C+J%3BBethel%2C+J%3BFlyer%2C+P%3BNugent%2C+R&rft.aulast=Mofenson&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17E, 1993, ISSN: 0730-2312 Poster Paper No. QZ 112 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss of growth factor stimulated signal transduction in NIH-3T3 cells expressing the HIV-1 nef gene AN - 41865109; 2935391 AU - De, S K AU - Marsh, J W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41865109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Loss+of+growth+factor+stimulated+signal+transduction+in+NIH-3T3+cells+expressing+the+HIV-1+nef+gene&rft.au=De%2C+S+K%3BMarsh%2C+J+W&rft.aulast=De&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17E, 1993, ISSN: 0730-2312 Poster Paper No. Q310 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA supercoiling and regulation of transcription: Analysis of the gyrA promoter AN - 41863494; 2941939 AU - Krah, R AU - Menzel, R AU - Gellert, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41863494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=DNA+supercoiling+and+regulation+of+transcription%3A+Analysis+of+the+gyrA+promoter&rft.au=Krah%2C+R%3BMenzel%2C+R%3BGellert%2C+M&rft.aulast=Krah&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Coral+Reefs&rft.issn=07224028&rft_id=info:doi/10.1007%2Fs00338-016-1407-2 LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17E, 1993, ISSN: 0730-2312 Poster Paper No. V206 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of genes selectively expressed in murine plasmacytomas AN - 41862926; 2902891 AU - Bergsagel, P L AU - Victor-Kobrin, C AU - Brents, LA AU - Kuehl, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41862926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+genes+selectively+expressed+in+murine+plasmacytomas&rft.au=Bergsagel%2C+P+L%3BVictor-Kobrin%2C+C%3BBrents%2C+LA%3BKuehl%2C+M&rft.aulast=Bergsagel&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17B 1993, ISSN: 0730-2312 Poster Paper No. FZ344 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anti-HIV activity of dideoxynucleosides in human resting and activated peripheral mononuclear cells AN - 41851573; 2930739 AU - Shirasaka, T AU - Gao, Wen-Yi AU - Kojima, E AU - Mitsuya, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41851573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Anti-HIV+activity+of+dideoxynucleosides+in+human+resting+and+activated+peripheral+mononuclear+cells&rft.au=Shirasaka%2C+T%3BGao%2C+Wen-Yi%3BKojima%2C+E%3BMitsuya%2C+H&rft.aulast=Shirasaka&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17E, 1993, ISSN: 0730-2312 Poster Paper No. Q 149 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IEGs are heterogeneously expressed in individual neurons and are specifically regulated by patterned neuronal activity AN - 41848880; 2943803 AU - Sheng, H Z AU - Fields, R D AU - Lin, P X AU - Nelson, P G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41848880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IEGs+are+heterogeneously+expressed+in+individual+neurons+and+are+specifically+regulated+by+patterned+neuronal+activity&rft.au=Sheng%2C+H+Z%3BFields%2C+R+D%3BLin%2C+P+X%3BNelson%2C+P+G&rft.aulast=Hong&rft.aufirst=J-S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Poster Paper No. PZ315 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Promiscuity of RANTES receptors on human monocytic cells: Competition for binding and desensitization of RANTES receptors by related chemotactic cytokines AN - 41846720; 2897667 AU - Wang, J M AU - McVicar, D W AU - Oppenheim, J J AU - Kelvin, D J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41846720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Promiscuity+of+RANTES+receptors+on+human+monocytic+cells%3A+Competition+for+binding+and+desensitization+of+RANTES+receptors+by+related+chemotactic+cytokines&rft.au=Wang%2C+J+M%3BMcVicar%2C+D+W%3BOppenheim%2C+J+J%3BKelvin%2C+D+J&rft.aulast=Wang&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17B 1993, ISSN: 0730-2312 Poster Paper No. E246 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of extracellular matrix (ECM) in airway epithelial cell differentiation AN - 41845104; 2941625 AU - Davenport, E A AU - Godfrey, V B AU - Randell, SH AU - Nettesheim, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41845104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+extracellular+matrix+%28ECM%29+in+airway+epithelial+cell+differentiation&rft.au=Davenport%2C+E+A%3BGodfrey%2C+V+B%3BRandell%2C+SH%3BNettesheim%2C+P&rft.aulast=Davenport&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17E, 1993, ISSN: 0730-2312 Poster Paper No. RZ406 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of established murine renal cell carcinoma with flavone-8-acetic acid (FAA) and rhIL-2 correlates with reversal of tumor-induced T-cell signal transduction defects AN - 41839906; 2938162 AU - Franco, J L AU - Wiltrout, R H AU - Mizoguchi, H AU - Ochoa, A C AU - O'Shea, J J AU - Longo, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41839906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Treatment+of+established+murine+renal+cell+carcinoma+with+flavone-8-acetic+acid+%28FAA%29+and+rhIL-2+correlates+with+reversal+of+tumor-induced+T-cell+signal+transduction+defects&rft.au=Franco%2C+J+L%3BWiltrout%2C+R+H%3BMizoguchi%2C+H%3BOchoa%2C+A+C%3BO%27Shea%2C+J+J%3BLongo%2C+D+L&rft.aulast=Franco&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Poster Paper No. NZ 607 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloned murine B lymphoma has generated variants with somatic mutations in H and L chain V regions AN - 41835557; 2907815 AU - Victor-Kobrin, C AU - Kuehl, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41835557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloned+murine+B+lymphoma+has+generated+variants+with+somatic+mutations+in+H+and+L+chain+V+regions&rft.au=Victor-Kobrin%2C+C%3BKuehl%2C+M&rft.aulast=Victor-Kobrin&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17B 1993, ISSN: 0730-2312 Poster Paper No. F335 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathogenesis of retrovirus-induced immunodeficiency in the mouse AN - 41834510; 2926445 AU - Morse, HC III AU - Huegin, A AU - Makino, M AU - Tang, Y AU - Selvey, L AU - Hodes, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pathogenesis+of+retrovirus-induced+immunodeficiency+in+the+mouse&rft.au=Morse%2C+HC+III%3BHuegin%2C+A%3BMakino%2C+M%3BTang%2C+Y%3BSelvey%2C+L%3BHodes%2C+R&rft.aulast=Morse&rft.aufirst=HC&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Paper No. N 027 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping the domains of the bovine papillomavirus-1 E2 protein which are required for interaction with the E1 protein AN - 41834343; 2946154 AU - Winokur, P L AU - Sarafi, T R AU - McBride, A A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mapping+the+domains+of+the+bovine+papillomavirus-1+E2+protein+which+are+required+for+interaction+with+the+E1+protein&rft.au=Winokur%2C+P+L%3BSarafi%2C+T+R%3BMcBride%2C+A+A&rft.aulast=Winokur&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Poster Paper No. M225 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of max and myc in differentiation of murine erythroleukemia cells stably transfected with max or c-, N- and L-myc AN - 41834125; 2884084 AU - Dunn, B AU - Cogliati, T AU - Cultraro, C AU - Segal, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41834125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+max+and+myc+in+differentiation+of+murine+erythroleukemia+cells+stably+transfected+with+max+or+c-%2C+N-+and+L-myc&rft.au=Dunn%2C+B%3BCogliati%2C+T%3BCultraro%2C+C%3BSegal%2C+S&rft.aulast=Dunn&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17A 1993, ISSN: 0730-2312 Poster Paper No. B624 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutational analysis of the m3 muscarinic receptor: Functional role of proline residues that are highly conserved among all g protein-coupled receptors AN - 41833922; 2910236 AU - Wess, J AU - Nanavati, S AU - Vogel, Z AU - Maggio, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41833922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mutational+analysis+of+the+m3+muscarinic+receptor%3A+Functional+role+of+proline+residues+that+are+highly+conserved+among+all+g+protein-coupled+receptors&rft.au=Wess%2C+J%3BNanavati%2C+S%3BVogel%2C+Z%3BMaggio%2C+R&rft.aulast=Wess&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Pergamon Press Inc., 660 White Plains Rd., Tarrytown, NY 10591-5153, USA; Internet: PPIERGAMON.COM, Papers and Abstracts, LIFE SCIENCES, Volume 52, Number 5/6, 1993, ISSN: 0024-3205 Poster Paper No. 17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transversion-mutation prone DNA synthesis in vitro with a natural base analog - 8-oxo-deoxyguanosine triphosphate AN - 41831135; 2933988 AU - Pavlov, YI AU - Kunkel, T A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41831135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+automated%2C+preparative+electrophoresis+to+facilitate+subcloning+of+fragments+for+sequence+analysis&rft.au=McCombie%2C+W+R%3BIovannisci%2C+D%3BEfcavitch%2C+J+W%3BVenter%2C+J+C&rft.aulast=McCombie&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 9th Floor, 605 Third Avenue, New York, NY 10158, USA; Telephone: (212) 850-6543, Abstracts, Environmental and Molecular Mutagenesis, Volume 21, Supplement 22, 1993, ISSN: 0893-6692 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toward understanding Trk/neurotrophin receptor function AN - 41830733; 2943477 AU - Soppet, D AU - Tsoulfas, P AU - Tessarollo, L AU - Reid, S AU - Blair, J AU - Mazzulla, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41830733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Toward+understanding+Trk%2Fneurotrophin+receptor+function&rft.au=Soppet%2C+D%3BTsoulfas%2C+P%3BTessarollo%2C+L%3BReid%2C+S%3BBlair%2C+J%3BMazzulla%2C+M&rft.aulast=Soppet&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Paper No. PZ010 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine-transfected 3T3 fibroblasts inhibit the progression of murine renal cancer AN - 41830065; 2937722 AU - Wiltrout, R H AU - Komschlies, K L AU - Franco, J L AU - Gruys, E AU - Back, T T AU - Pardoll, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41830065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytokine-transfected+3T3+fibroblasts+inhibit+the+progression+of+murine+renal+cancer&rft.au=Wiltrout%2C+R+H%3BKomschlies%2C+K+L%3BFranco%2C+J+L%3BGruys%2C+E%3BBack%2C+T+T%3BPardoll%2C+D+M&rft.aulast=Wiltrout&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Poster Paper No. NZ 411 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stage-specific changes in transcription factor expression during normal B cell development AN - 41829594; 2885031 AU - Scherle, P AU - Holmes, K AU - Staudt, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41829594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Retroviral+integrase+-+Crystal+structure+of+a+new+target+for+designing+drugs+against+AIDS&rft.au=Wlodawer%2C+A%3BBujacz%2C+G%3BJaskolski%2C+M%3BAlexandratos%2C+J%3BMerkel%2C+G%3BKatz%2C+R+A%3BSkalka%2C+A+M&rft.aulast=Wlodawer&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17A 1993, ISSN: 0730-2312 Poster Paper No. B976 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multidrug resistance as a selectable marker in gene therapy AN - 41828899; 2943900 AU - Gottesman, M M AU - Pastan, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41828899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Multidrug+resistance+as+a+selectable+marker+in+gene+therapy&rft.au=Gottesman%2C+M+M%3BPastan%2C+I&rft.aulast=Gottesman&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17E, 1993, ISSN: 0730-2312 Paper No. SZ011 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of the human heat shock response AN - 41827515; 2883005 AU - Rabindran, S K AU - Haroun, R I AU - Wu, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41827515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+the+human+heat+shock+response&rft.au=Rabindran%2C+S+K%3BHaroun%2C+R+I%3BWu%2C+C&rft.aulast=Rabindran&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17A 1993, ISSN: 0730-2312 Poster Paper No. B205 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of restriction endonucleases on HIV infection AN - 41820998; 2928672 AU - Sechler, JMG AU - Clouse, KA AU - Strebel, K AU - Weih, KA AU - Rosenberg, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41820998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+restriction+endonucleases+on+HIV+infection&rft.au=Sechler%2C+JMG%3BClouse%2C+KA%3BStrebel%2C+K%3BWeih%2C+KA%3BRosenberg%2C+A+S&rft.aulast=Sechler&rft.aufirst=JMG&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Poster Paper No. N 356 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T cell receptor variable gene usage in melanoma specific TIL clones and lines AN - 41820732; 2937213 AU - Shilyansky, J AU - Nishimura, MI AU - Yanelli, JR AU - Kawakami, Y AU - O'Neil, B AU - Mule, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41820732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=T+cell+receptor+variable+gene+usage+in+melanoma+specific+TIL+clones+and+lines&rft.au=Shilyansky%2C+J%3BNishimura%2C+MI%3BYanelli%2C+JR%3BKawakami%2C+Y%3BO%27Neil%2C+B%3BMule%2C+J+J&rft.aulast=Shilyansky&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17D, 1993, ISSN: 0730-2312 Poster Paper No. NZ 219 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suramin induces tyrosine phosphorylation and inhibits cellular proliferation in a human B-lymphoblast cell line AN - 41817446; 2892640 AU - Sartor, O AU - McLellan, CA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41817446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Suramin+induces+tyrosine+phosphorylation+and+inhibits+cellular+proliferation+in+a+human+B-lymphoblast+cell+line&rft.au=Sartor%2C+O%3BMcLellan%2C+CA&rft.aulast=Sartor&rft.aufirst=O&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17A 1993, ISSN: 0730-2312 Poster Paper No. BZ145 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural investigation of a putative minor groove binding protein: E. coli integration host factor bound to a 30bp binding site AN - 41816275; 2899967 AU - Werner, M H AU - Clore, G M AU - Gronenborn, A AU - Nash, HA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41816275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structural+investigation+of+a+putative+minor+groove+binding+protein%3A+E.+coli+integration+host+factor+bound+to+a+30bp+binding+site&rft.au=Werner%2C+M+H%3BClore%2C+G+M%3BGronenborn%2C+A%3BNash%2C+HA&rft.aulast=Werner&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17C 1993, ISSN: 0730-2312 Poster Paper No. LZ459 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of c-kit ligand and proinflammatory cytokines in radioprotection of mice AN - 41812816; 2897421 AU - Neta, R AU - Liedman, JE AU - Mitchell, J AU - Williams, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41812816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparison+of+c-kit+ligand+and+proinflammatory+cytokines+in+radioprotection+of+mice&rft.au=Neta%2C+R%3BLiedman%2C+JE%3BMitchell%2C+J%3BWilliams%2C+D&rft.aulast=Neta&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17B 1993, ISSN: 0730-2312 Poster Paper No. E131 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mos proto-oncogene and cell cycle regulation AN - 41812150; 2882636 AU - Vande Woude, GF AU - Zhou, R AU - Daar, I AU - Yew, N AU - Matten, W AU - Fukasawa, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41812150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Psychophysiological+predictors+of+empathy+and+externalizing+problems+in+middle+childhood&rft.au=Hastings%2C+P+D%3BZahn-Waxler%2C+C&rft.aulast=Hastings&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17A 1993, ISSN: 0730-2312 Paper No. B010 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell type-dependent regulation of gene expression of a nonmuscle myosin heavy chain AN - 41809567; 2884910 AU - Kawamoto, S AU - Chopra, R K AU - Kitagawa, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41809567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cell+type-dependent+regulation+of+gene+expression+of+a+nonmuscle+myosin+heavy+chain&rft.au=Kawamoto%2C+S%3BChopra%2C+R+K%3BKitagawa%2C+G&rft.aulast=Kawamoto&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 605 Third Avenue, 9th Floor, New York, NY 10158-0012, USA; Telephone: (212) 850-6543, Abstracts, Journal of Cellular Biochemistry, Supplement 17A 1993, ISSN: 0730-2312 Poster Paper No. B936 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor necrosis factor-alpha (TNF-alpha) directly inhibits and indirectly enhances hematopoietic progenitor cell proliferation: Correlation with colony stimulating factor (CSF) receptor modulation AN - 41794172; 2819581 AU - Keller, J R AU - Ruscetti, F W AU - Jacobsen, SEW Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41794172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tumor+necrosis+factor-alpha+%28TNF-alpha%29+directly+inhibits+and+indirectly+enhances+hematopoietic+progenitor+cell+proliferation%3A+Correlation+with+colony+stimulating+factor+%28CSF%29+receptor+modulation&rft.au=Keller%2C+J+R%3BRuscetti%2C+F+W%3BJacobsen%2C+SEW&rft.aulast=Keller&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Springer-Verlag New York Inc., Journal Fulfillment Services, 44 Hartz Way, Seacaucus, NJ 07096, USA; Telephone: 1-800-SPRINGER; Telex: 12 59 94, Abstracts, Experimental Hematology, Volume 20, Number 6, July 1992, ISSN: 0301-472X Poster Paper No. 213 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of human CD34 positive progenitor cell growth and differentiation by transforming growth factor-B AN - 41791003; 2819810 AU - Falk, LA AU - Kessler, S AU - Ruscetti, F W AU - Longo, D AU - Kenny, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41791003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+human+CD34+positive+progenitor+cell+growth+and+differentiation+by+transforming+growth+factor-B&rft.au=Falk%2C+LA%3BKessler%2C+S%3BRuscetti%2C+F+W%3BLongo%2C+D%3BKenny%2C+J+J&rft.aulast=Falk&rft.aufirst=LA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Springer-Verlag New York Inc., Journal Fulfillment Services, 44 Hartz Way, Seacaucus, NJ 07096, USA; Telephone: 1-800-SPRINGER; Telex: 12 59 94, Abstracts, Experimental Hematology, Volume 20, Number 6, July 1992, ISSN: 0301-472X Poster Paper No. 132 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NPC 15437, a selective protein kinase C inhibitor alters HIV-1 infectivity AN - 41728506; 2666454 AU - Coggiano, M AU - Sweetnam, P AU - Kulaga, H AU - Sullivan, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41728506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=NPC+15437%2C+a+selective+protein+kinase+C+inhibitor+alters+HIV-1+infectivity&rft.au=Coggiano%2C+M%3BSweetnam%2C+P%3BKulaga%2C+H%3BSullivan%2C+J&rft.aulast=Coggiano&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. W.A.1069 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human astrocytes stimulate HIV-1 expression in a chronically infected promonocyte clone via interleukin-6 AN - 41717314; 2668130 AU - Vitkovic, L AU - Wood, G AU - Major, E O AU - Fauci, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41717314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+astrocytes+stimulate+HIV-1+expression+in+a+chronically+infected+promonocyte+clone+via+interleukin-6&rft.au=Vitkovic%2C+L%3BWood%2C+G%3BMajor%2C+E+O%3BFauci%2C+A+S&rft.aulast=Vitkovic&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. W.A.1284 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ribozymes as anti-HIV agents: Insertion of cis and trans ribozymes into the HIV-genome AN - 41715743; 2656696 AU - Lin, N H AU - Dropulic, B AU - Graham, K B AU - Jeang, K T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41715743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ribozymes+as+anti-HIV+agents%3A+Insertion+of+cis+and+trans+ribozymes+into+the+HIV-genome&rft.au=Lin%2C+N+H%3BDropulic%2C+B%3BGraham%2C+K+B%3BJeang%2C+K+T&rft.aulast=Lin&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. M.A.1218 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequence-specific recognition of car/rre, the target sequence for the REV axis of HIV-1 AN - 41715206; 2656510 AU - Dayton, E T AU - Konings, D AU - Powell, D AU - Shapiro, B AU - Maizel, J AU - Dayton, AI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41715206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sequence-specific+recognition+of+car%2Frre%2C+the+target+sequence+for+the+REV+axis+of+HIV-1&rft.au=Dayton%2C+E+T%3BKonings%2C+D%3BPowell%2C+D%3BShapiro%2C+B%3BMaizel%2C+J%3BDayton%2C+AI&rft.aulast=Dayton&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. M.A.1174 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infectivity of HIV-2 mutants in rhesus macaques AN - 41712766; 2665748 AU - Franchini, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41712766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Infectivity+of+HIV-2+mutants+in+rhesus+macaques&rft.au=Franchini%2C+G&rft.aulast=Franchini&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Paper No. TH.A.7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the HIV-1 vpu protein in viral replication: Effects on cell surface expression of the envelope glycoprotein AN - 41712499; 2665083 AU - Willey, R AU - Maldarelli, F AU - Martin, M AU - Klaus, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41712499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+the+HIV-1+vpu+protein+in+viral+replication%3A+Effects+on+cell+surface+expression+of+the+envelope+glycoprotein&rft.au=Willey%2C+R%3BMaldarelli%2C+F%3BMartin%2C+M%3BKlaus%2C+S&rft.aulast=Willey&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Paper No. W.A.22 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Markers predictive for the development of opportunistic non-Hodgkin's lymphoma (NHL) in patients with severe HIV infection on long-term antiretroviral therapy AN - 41711427; 2654854 AU - Lietzau, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41711427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chloride+transport+studies+in+brain+synaptoneurosomes%3A+Effects+of+the+GABA+agonists+and+antagonists%2C+pentobarbital%2C+flurazepam+and+the+role+of+phospholipase+A+super%282%29&rft.au=Paul%2C+S+M%3BSchwartz%2C+R+D%3BSkolnick%2C+P%3BJackson%2C+J&rft.aulast=Paul&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Paper No. TU.B.4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diaryl sulfones - a unique class of anti-HIV agents AN - 41710497; 2666458 AU - Schultz, R J AU - Narayanan, V AU - Bader, J AU - Pedemonte, R AU - Wassmundt, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41710497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Diaryl+sulfones+-+a+unique+class+of+anti-HIV+agents&rft.au=Schultz%2C+R+J%3BNarayanan%2C+V%3BBader%2C+J%3BPedemonte%2C+R%3BWassmundt%2C+F&rft.aulast=Schultz&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. W.A.1072 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuropsychologic results of control HIV-1 trial of peptide T AN - 41710231; 2666187 AU - Bridge, P AU - Linde, R AU - Ollo, C AU - Mayer, K AU - Ruff, M AU - Pert, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41710231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neuropsychologic+results+of+control+HIV-1+trial+of+peptide+T&rft.au=Bridge%2C+P%3BLinde%2C+R%3BOllo%2C+C%3BMayer%2C+K%3BRuff%2C+M%3BPert%2C+C&rft.aulast=Bridge&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Paper No. TH.B.90 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Linear polymers of CD4 as polyvalent molecular decoys AN - 41706892; 2657961 AU - Smythe, JA AU - Nardelli, B AU - Chatterjee, P AU - Gallo, R C AU - Gershoni, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41706892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Linear+polymers+of+CD4+as+polyvalent+molecular+decoys&rft.au=Smythe%2C+JA%3BNardelli%2C+B%3BChatterjee%2C+P%3BGallo%2C+R+C%3BGershoni%2C+J+M&rft.aulast=Smythe&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. M.A.1357 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HHV-6 as a potential cofactor in AIDS: Transcriptional activation of CD4 and induction of susceptibility to HIV-1 infection in CD8+ T lymphocytes AN - 41702595; 2654585 AU - Lusso, P AU - Malnati, M AU - De Maria, A AU - Lori, F AU - Garzino-Demo, A AU - Arya, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41702595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HHV-6+as+a+potential+cofactor+in+AIDS%3A+Transcriptional+activation+of+CD4+and+induction+of+susceptibility+to+HIV-1+infection+in+CD8%2B+T+lymphocytes&rft.au=Lusso%2C+P%3BMalnati%2C+M%3BDe+Maria%2C+A%3BLori%2C+F%3BGarzino-Demo%2C+A%3BArya%2C+S&rft.aulast=Lusso&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Paper No. M.A.32 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of HIV sequences which inhibit the synthesis of viral structural proteins AN - 41678638; 2655041 AU - Maldarelli, F AU - Martin, MA AU - Strebel, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41678638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+HIV+sequences+which+inhibit+the+synthesis+of+viral+structural+proteins&rft.au=Maldarelli%2C+F%3BMartin%2C+MA%3BStrebel%2C+K&rft.aulast=Maldarelli&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Paper No. TU.A.72 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does a precipitous decline in the diffusing capacity in asymptomatic HIV-infected persons predict the presence of PCP or other pulmonary infection? AN - 41676719; 2658797 AU - Kvale, P AU - Rosen, M AU - Game, S AU - Markowitz, N AU - Johnson, C AU - Saravolatz, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41676719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Does+a+precipitous+decline+in+the+diffusing+capacity+in+asymptomatic+HIV-infected+persons+predict+the+presence+of+PCP+or+other+pulmonary+infection%3F&rft.au=Kvale%2C+P%3BRosen%2C+M%3BGame%2C+S%3BMarkowitz%2C+N%3BJohnson%2C+C%3BSaravolatz%2C+L&rft.aulast=Kvale&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. M.B.2161 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuropsychiatric complications of interferon-alpha treated patients with histories of affective symptomatology or substance use AN - 41676460; 2658266 AU - Govoni, L AU - Davey, V AU - Ropka, ME AU - Demitrak, MA AU - Lane, H C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41676460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neuropsychiatric+complications+of+interferon-alpha+treated+patients+with+histories+of+affective+symptomatology+or+substance+use&rft.au=Govoni%2C+L%3BDavey%2C+V%3BRopka%2C+ME%3BDemitrak%2C+MA%3BLane%2C+H+C&rft.aulast=Govoni&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. M.B.2106 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Soluble CD4 inhibits HIV gp120-induced impairment of signal transduction in human CD8+ T cells AN - 41668820; 2656833 AU - Sei, Y AU - Arora, P K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41668820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Soluble+CD4+inhibits+HIV+gp120-induced+impairment+of+signal+transduction+in+human+CD8%2B+T+cells&rft.au=Sei%2C+Y%3BArora%2C+P+K&rft.aulast=Sei&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Attn.: Cecilia Avico, VIIth International Conference on AIDS, Istituto Superiore di Sanita, Laboratory of Virology, Viale Regina Elena, 299, 00161 Rome, Italy, Abstracts Poster Paper No. M.A.1267 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Social status dependent effects of centrally administered oxytocin in male squirrel monkeys AN - 41662293; 2563123 AU - Winslow, J T AU - Insel, T R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41662293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genome-wide+search+for+genes+influencing+serum+lipid+concentrations+in+Pima+Indians&rft.au=Imperatore%2C+G%3BHanson%2C+R+L%3BPettitt%2C+D+J%3BKobes%2C+S%3BBennett%2C+PH%3BKnowler%2C+W+C&rft.aulast=Imperatore&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: NYAS, 2 East 63rd Street, New York, NY 10021, USA, Poster Paper No. 15 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene amplification of human endogenous retrovirus-like sequences from brain tissue of multiple sclerosis patients and controls AN - 41658152; 2528468 AU - Glovinsky, D AU - Kulaga, H AU - Alexander, R AU - Adams, A AU - Coggiano, M AU - Truckenmiller, ME Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41658152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Gene+amplification+of+human+endogenous+retrovirus-like+sequences+from+brain+tissue+of+multiple+sclerosis+patients+and+controls&rft.au=Glovinsky%2C+D%3BKulaga%2C+H%3BAlexander%2C+R%3BAdams%2C+A%3BCoggiano%2C+M%3BTruckenmiller%2C+ME&rft.aulast=Glovinsky&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-1 activation of the jun gene AN - 41656662; 2519523 AU - Muegge, K AU - Vila, M AU - Musso, T AU - Herrlich, P AU - Durum, S K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41656662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IL-1+activation+of+the+jun+gene&rft.au=Muegge%2C+K%3BVila%2C+M%3BMusso%2C+T%3BHerrlich%2C+P%3BDurum%2C+S+K&rft.aulast=Muegge&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Desensitization of DDT sub(1) MF-2 cells to R-PIA is associated with down regulation and phosphorylation of A sub(1) adenosine receptor AN - 41655100; 2530676 AU - Ramkumar, V AU - Olah, ME AU - Jacobson, KA AU - Stiles, G L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41655100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Desensitization+of+DDT+sub%281%29+MF-2+cells+to+R-PIA+is+associated+with+down+regulation+and+phosphorylation+of+A+sub%281%29+adenosine+receptor&rft.au=Ramkumar%2C+V%3BOlah%2C+ME%3BJacobson%2C+KA%3BStiles%2C+G+L&rft.aulast=Ramkumar&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coccidioidal infections treated with SCH39304 AN - 41650995; 2593263 AU - Galgiani, J N AU - Hostetler, J AU - Catanzaro, A AU - Graybill, J R AU - Larsen, R A AU - Tucker, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41650995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Coccidioidal+infections+treated+with+SCH39304&rft.au=Galgiani%2C+J+N%3BHostetler%2C+J%3BCatanzaro%2C+A%3BGraybill%2C+J+R%3BLarsen%2C+R+A%3BTucker%2C+R&rft.aulast=Galgiani&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ISHAM 1991, Congress Coordinators/Secretariat, JPdL Multimanagement Inc., 1410 Stanley St., Suite 609, Montreal, Que. H3A 1P8, Canada, Abstracts Poster Paper No. PS3.107 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Iron catalyzed oxidative modification of glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides AN - 41642422; 2508661 AU - Szweda, LI AU - Stadtman, E R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41642422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Iron+catalyzed+oxidative+modification+of+glucose-6-phosphate+dehydrogenase+from+Leuconostoc+mesenteroides&rft.au=Szweda%2C+LI%3BStadtman%2C+E+R&rft.aulast=Szweda&rft.aufirst=LI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Desensitization of human beta sub(1)-adrenergic and D sub(1) dopaminergic receptors: Differences in action of protein kinases AN - 41637088; 2496125 AU - Zhou, X-M AU - Sidhu, A AU - Fishman, PH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41637088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Desensitization+of+human+beta+sub%281%29-adrenergic+and+D+sub%281%29+dopaminergic+receptors%3A+Differences+in+action+of+protein+kinases&rft.au=Zhou%2C+X-M%3BSidhu%2C+A%3BFishman%2C+PH&rft.aulast=Zhou&rft.aufirst=X-M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation-independent adhesion of CD4+CD45RO+ memory T cells to ELAM-1 AN - 41636913; 2528965 AU - Shimizu, Y AU - Shaw, S AU - Graber, N AU - Gopal, T V AU - Horgan, K J AU - van Seventer, GA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41636913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Activation-independent+adhesion+of+CD4%2BCD45RO%2B+memory+T+cells+to+ELAM-1&rft.au=Shimizu%2C+Y%3BShaw%2C+S%3BGraber%2C+N%3BGopal%2C+T+V%3BHorgan%2C+K+J%3Bvan+Seventer%2C+GA&rft.aulast=Shimizu&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular cloning, expression, and functional characterization of three classes of mammalian ADP-ribosylation factors AN - 41636000; 2507082 AU - Welsh, C F AU - Price AU - Tsuchiya, M AU - Stanley, S J AU - Nightingale AU - Lee, C-M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41636000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+cloning%2C+expression%2C+and+functional+characterization+of+three+classes+of+mammalian+ADP-ribosylation+factors&rft.au=Welsh%2C+C+F%3BPrice%3BTsuchiya%2C+M%3BStanley%2C+S+J%3BNightingale%3BLee%2C+C-M&rft.aulast=Welsh&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and expression of two novel homeotic genes in human lymphoid cells AN - 41632662; 2529189 AU - Deguchi, Y AU - Fauci, A S AU - Kehri, J H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41632662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+and+expression+of+two+novel+homeotic+genes+in+human+lymphoid+cells&rft.au=Deguchi%2C+Y%3BFauci%2C+A+S%3BKehri%2C+J+H&rft.aulast=Deguchi&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single amino acid substitution (Ser super(180) Cys) is responsible for the phenotypic variation in expression of cytochrome P-450g (2C13) AN - 41631829; 2516450 AU - Faletto, M B AU - Linko, P AU - Goldstein, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41631829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Single+amino+acid+substitution+%28Ser+super%28180%29+Cys%29+is+responsible+for+the+phenotypic+variation+in+expression+of+cytochrome+P-450g+%282C13%29&rft.au=Faletto%2C+M+B%3BLinko%2C+P%3BGoldstein%2C+JA&rft.aulast=MacLean&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of IgG hinge region alterations on the formation of immobilized immune complexes AN - 41630069; 2528650 AU - Horgan, C AU - Brown, K AU - Pincus, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41630069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+IgG+hinge+region+alterations+on+the+formation+of+immobilized+immune+complexes&rft.au=Horgan%2C+C%3BBrown%2C+K%3BPincus%2C+S&rft.aulast=Horgan&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of inhibin during long to short photoperiod transition in the hamster AN - 41628650; 2596399 AU - Culler, MD AU - Merchenthaler, I AU - Heindel, J J AU - Wetsel, W C AU - Negro-Vilar, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41628650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+inhibin+during+long+to+short+photoperiod+transition+in+the+hamster&rft.au=Culler%2C+MD%3BMerchenthaler%2C+I%3BHeindel%2C+J+J%3BWetsel%2C+W+C%3BNegro-Vilar%2C+A&rft.aulast=Culler&rft.aufirst=MD&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820, USA. Telephone: (217) 356-3182. Fax: (217) 398-4119., Biology of Reproduction, ISSN: 0006-3363, Supplement Number 1, Volume 44 Paper No. 389 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure of the bovine gene for ADP-ribosylation factor 2, a similar to 20 kDa guanine-nucleotide binding protein that activates cholera toxin AN - 41626870; 2516596 AU - Serventi, I M AU - Cavanaugh, E AU - Tsuchiya, M AU - Price AU - Nightingale, M AU - Moss, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41626870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structure+of+the+bovine+gene+for+ADP-ribosylation+factor+2%2C+a+similar+to+20+kDa+guanine-nucleotide+binding+protein+that+activates+cholera+toxin&rft.au=Serventi%2C+I+M%3BCavanaugh%2C+E%3BTsuchiya%2C+M%3BPrice%3BNightingale%2C+M%3BMoss%2C+J&rft.aulast=Serventi&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and sequencing of the first rat mdr cDNA AN - 41622538; 2516890 AU - Silverman, JA AU - Raunio, H AU - Gant, T W AU - Marino, P A AU - Thorgeirsson, S S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41622538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+and+sequencing+of+the+first+rat+mdr+cDNA&rft.au=Silverman%2C+JA%3BRaunio%2C+H%3BGant%2C+T+W%3BMarino%2C+P+A%3BThorgeirsson%2C+S+S&rft.aulast=Silverman&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the gene encoding the human GABA sub(A) receptor beta 1 subunit AN - 41620726; 2508002 AU - Kirkness, E F AU - Kusiak, J W AU - Fleming, J T AU - Menninger, J AU - Gocayna, J D AU - Ward, D C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41620726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preparation+and+characterization+of+rabbit-mouse+hybridomas&rft.au=Sogn%2C+JA%3BKuo%2C+M-C%3BKindt%2C+T+J&rft.aulast=Sogn&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Murine IL-4 production in response to immobilized anti-CD3 is IL-2 dependent. Analysis of IL-4 mRNA AN - 41618816; 2455677 AU - Boulay, J-L AU - Seder, R A AU - Paul, W E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41618816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Murine+IL-4+production+in+response+to+immobilized+anti-CD3+is+IL-2+dependent.+Analysis+of+IL-4+mRNA&rft.au=Boulay%2C+J-L%3BSeder%2C+R+A%3BPaul%2C+W+E&rft.aulast=Boulay&rft.aufirst=J-L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. P 207 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Catalysis of methyl group transfer from acetyl CoA to tetrahydrosarcinapterin by a carbon monoxide dehydrogenase-corrinoid enzyme complex from Methanosarcina barkeri AN - 41618405; 2517127 AU - Grahame, DA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41618405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Catalysis+of+methyl+group+transfer+from+acetyl+CoA+to+tetrahydrosarcinapterin+by+a+carbon+monoxide+dehydrogenase-corrinoid+enzyme+complex+from+Methanosarcina+barkeri&rft.au=Grahame%2C+DA&rft.aulast=Grahame&rft.aufirst=DA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stimulation of T cells using antibody heteroconjugates containing anti-TCR and anti-MHC class II Fab fragments AN - 41618377; 2522906 AU - Wu, S M AU - Segal, D M AU - Ashwell, J D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41618377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stimulation+of+T+cells+using+antibody+heteroconjugates+containing+anti-TCR+and+anti-MHC+class+II+Fab+fragments&rft.au=Wu%2C+S+M%3BSegal%2C+D+M%3BAshwell%2C+J+D&rft.aulast=Wu&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular senescence and cancer AN - 41617932; 2522621 AU - Barrett, J C AU - Futreal, P A AU - Annab, LA AU - Bivins, H AU - Richter, H AU - Oshimura, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41617932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cellular+senescence+and+cancer&rft.au=Barrett%2C+J+C%3BFutreal%2C+P+A%3BAnnab%2C+LA%3BBivins%2C+H%3BRichter%2C+H%3BOshimura%2C+M&rft.aulast=Barrett&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heavy chain contribution to antigen binding and effector function of an anti-human colorectal carcinoma monoclonal antibody AN - 41617841; 2505171 AU - Tsang, KY AU - Kashmiri, S AU - Masci, A M AU - Primus, F J AU - Schlom, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41617841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Heavy+chain+contribution+to+antigen+binding+and+effector+function+of+an+anti-human+colorectal+carcinoma+monoclonal+antibody&rft.au=Tsang%2C+KY%3BKashmiri%2C+S%3BMasci%2C+A+M%3BPrimus%2C+F+J%3BSchlom%2C+J&rft.aulast=Tsang&rft.aufirst=KY&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of natural antibody on cross-species bone marrow engraftment AN - 41616951; 2505097 AU - Aksentijevich, I AU - Sachs, D H AU - Sykes, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41616951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+natural+antibody+on+cross-species+bone+marrow+engraftment&rft.au=Aksentijevich%2C+I%3BSachs%2C+D+H%3BSykes%2C+M&rft.aulast=Aksentijevich&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular inorganic ion content and Delta G ATP hydrolysis in lymphoblasts from normal subjects, heterzygotes and homozygotes for cystic fibrosis AN - 41614309; 2510136 AU - Kim, Y-A AU - Veech, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41614309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intracellular+inorganic+ion+content+and+Delta+G+ATP+hydrolysis+in+lymphoblasts+from+normal+subjects%2C+heterzygotes+and+homozygotes+for+cystic+fibrosis&rft.au=Kim%2C+Y-A%3BVeech%2C+R+L&rft.aulast=Kim&rft.aufirst=Y-A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of cytolytic T lymphocyte responses by an inhibitor of serine/threonine protein phosphatase(s) AN - 41613445; 2522887 AU - Taffs, R AU - Redegeld, F AU - Sitkovsky, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41613445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modulation+of+cytolytic+T+lymphocyte+responses+by+an+inhibitor+of+serine%2Fthreonine+protein+phosphatase%28s%29&rft.au=Taffs%2C+R%3BRedegeld%2C+F%3BSitkovsky%2C+M&rft.aulast=Taffs&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytotoxic T lymphocytes specific for gp160 peptides in HIV seropositive individuals AN - 41612295; 2500449 AU - Clerici, M AU - Berzofsky, JA AU - Shearer, G M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41612295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytotoxic+T+lymphocytes+specific+for+gp160+peptides+in+HIV+seropositive+individuals&rft.au=Clerici%2C+M%3BBerzofsky%2C+JA%3BShearer%2C+G+M&rft.aulast=Clerici&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse lung enzyme induction following a single high dose of Aroclor 1254 AN - 41610419; 2433085 AU - Beebe, L AU - Anderson, L AU - Fox, S D AU - Isaaq, H AU - Park, S S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41610419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mouse+lung+enzyme+induction+following+a+single+high+dose+of+Aroclor+1254&rft.au=Beebe%2C+L%3BAnderson%2C+L%3BFox%2C+S+D%3BIsaaq%2C+H%3BPark%2C+S+S&rft.aulast=Beebe&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th Street, NW, Suite 1100, Washington, DC 20005, USA. Telephone: (202) 371-1393. Fax: (202) 371-1090., Poster Paper No. 822 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered growth factor signaling pathways in human cancer cells AN - 41609782; 2420240 AU - Aaronson, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:MUTIDISCIPLINARY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41609782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Altered+growth+factor+signaling+pathways+in+human+cancer+cells&rft.au=Aaronson%2C+SA&rft.aulast=Aaronson&rft.aufirst=SA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AAAS Books, Dept. 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Box 753, Waldorf, MD 20604, USA. Telephone: (301) 645-5643 ask for AAAS. Fax: (301) 843-0159., Abstracts, 91-02, $8.00 members/$10.00 non-members plus $4.00 postage/handling N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure and function of interleukin 2-receptors (IL-2R) on spindle cells of AIDS-associated Kaposi's sarcoma (AIDS-KS) AN - 41608678; 2456572 AU - Lunardi-Iskandar, Y AU - Nakamura, S AU - Gill, P AU - Sakurada, S AU - Salahuddin, S Z AU - Gallo, R C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41608678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structure+and+function+of+interleukin+2-receptors+%28IL-2R%29+on+spindle+cells+of+AIDS-associated+Kaposi%27s+sarcoma+%28AIDS-KS%29&rft.au=Lunardi-Iskandar%2C+Y%3BNakamura%2C+S%3BGill%2C+P%3BSakurada%2C+S%3BSalahuddin%2C+S+Z%3BGallo%2C+R+C&rft.aulast=Lunardi-Iskandar&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. P 530 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental appearance of cytosolic G beta , cytosolic MEKA, and membrane associated G-proteins in the rat pineal gland AN - 41607841; 2501401 AU - Babila, T AU - Schaad, N C AU - Spiegel, A M AU - Shinohara, T AU - Klein, D C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41607841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Developmental+appearance+of+cytosolic+G+beta+%2C+cytosolic+MEKA%2C+and+membrane+associated+G-proteins+in+the+rat+pineal+gland&rft.au=Babila%2C+T%3BSchaad%2C+N+C%3BSpiegel%2C+A+M%3BShinohara%2C+T%3BKlein%2C+D+C&rft.aulast=Babila&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autoproteolytic cleavage of purified HIV-1 protease AN - 41606677; 2491287 AU - Forsberg, G AU - Zachrisson, K AU - Larsson, B AU - Levine, R L AU - Hartmanis, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41606677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Autoproteolytic+cleavage+of+purified+HIV-1+protease&rft.au=Forsberg%2C+G%3BZachrisson%2C+K%3BLarsson%2C+B%3BLevine%2C+R+L%3BHartmanis%2C+M&rft.aulast=Forsberg&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transforming growth factor-B (TGF-B) inhibits the synergistic effect of IL-6, IL-1 and G-CSF on IL-3 induced growth of isolated hematopoietic progenitors AN - 41606342; 2455564 AU - Sill, K T AU - Ruscetti, F W AU - Keller, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41606342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transforming+growth+factor-B+%28TGF-B%29+inhibits+the+synergistic+effect+of+IL-6%2C+IL-1+and+G-CSF+on+IL-3+induced+growth+of+isolated+hematopoietic+progenitors&rft.au=Sill%2C+K+T%3BRuscetti%2C+F+W%3BKeller%2C+J+R&rft.aulast=Sill&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. P 132 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning of cDNA for a human cardiac cGMP-inhibited low K sub(m) cAMP phosphodiesterase AN - 41605737; 2491386 AU - Meacci, E AU - Moos, M Jr AU - Taira, M AU - Smith, C J AU - Vasta, V AU - Degerman, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41605737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+of+cDNA+for+a+human+cardiac+cGMP-inhibited+low+K+sub%28m%29+cAMP+phosphodiesterase&rft.au=Meacci%2C+E%3BMoos%2C+M+Jr%3BTaira%2C+M%3BSmith%2C+C+J%3BVasta%2C+V%3BDegerman%2C+E&rft.aulast=Meacci&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interleukin-1 alpha (IL-1 alpha ) and myelopoiesis in vivo: Modulation of colony stimulating factor receptor expression on bone marrow cells after IL-1 alpha in vivo AN - 41605240; 2456111 AU - Hestdal, K AU - Jacobsen, SEW AU - Dubois, C M AU - Ruscetti, F W AU - Oppenheim, J J AU - Longo, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41605240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interleukin-1+alpha+%28IL-1+alpha+%29+and+myelopoiesis+in+vivo%3A+Modulation+of+colony+stimulating+factor+receptor+expression+on+bone+marrow+cells+after+IL-1+alpha+in+vivo&rft.au=Hestdal%2C+K%3BJacobsen%2C+SEW%3BDubois%2C+C+M%3BRuscetti%2C+F+W%3BOppenheim%2C+J+J%3BLongo%2C+D+L&rft.aulast=Hestdal&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. P 323 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of genes expressed in mouse plasmacytomas, but not B lymphomas AN - 41603697; 2487433 AU - Bergsagel, P L AU - Timblin, C AU - Kuehl, WM Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41603697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+genes+expressed+in+mouse+plasmacytomas%2C+but+not+B+lymphomas&rft.au=Bergsagel%2C+P+L%3BTimblin%2C+C%3BKuehl%2C+WM&rft.aulast=Bergsagel&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15G, 1991; ISSN: 0730-2312 Poster Paper No. S 208 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cooperative trans-activation of HIV-1 LTR by TAT and a TAR RNA-binding protein AN - 41602138; 2483451 AU - Gatignol, A AU - Jeang, Kuan-Teh Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41602138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cooperative+trans-activation+of+HIV-1+LTR+by+TAT+and+a+TAR+RNA-binding+protein&rft.au=Gatignol%2C+A%3BJeang%2C+Kuan-Teh&rft.aulast=Gatignol&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts, Journal of Acquired Immune Deficiency Syndromes, Vol. 4, No. 3, 1991 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transfection of the HLA-A2.1 gene into non-HLA-A2 allogeneic melanomas allows the recognition of shared melanoma antigen by HLA-A2 restricted melanoma specific cytotoxic T cells AN - 41600910; 2519550 AU - Kawakami, Y AU - Zakut, R AU - Topalian, S AU - Rosenberg, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41600910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transfection+of+the+HLA-A2.1+gene+into+non-HLA-A2+allogeneic+melanomas+allows+the+recognition+of+shared+melanoma+antigen+by+HLA-A2+restricted+melanoma+specific+cytotoxic+T+cells&rft.au=Kawakami%2C+Y%3BZakut%2C+R%3BTopalian%2C+S%3BRosenberg%2C+SA&rft.aulast=Kawakami&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and characterization of G protein-coupled receptors in the mouse-guinea pig cochlea AN - 41600698; 2416504 AU - Wilcox, E R AU - Grundfast, K M AU - Tachibana, M AU - Fex, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41600698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+and+characterization+of+G+protein-coupled+receptors+in+the+mouse-guinea+pig+cochlea&rft.au=Wilcox%2C+E+R%3BGrundfast%2C+K+M%3BTachibana%2C+M%3BFex%2C+J&rft.aulast=Wilcox&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recovery of extracellular Borrelia burgdorferi antigens from tissues and fluids of mammalian and arthropod hosts AN - 41599327; 2541403 AU - Dorward, D W AU - Schwan, T G AU - Garon, C F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41599327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Recovery+of+extracellular+Borrelia+burgdorferi+antigens+from+tissues+and+fluids+of+mammalian+and+arthropod+hosts&rft.au=Dorward%2C+D+W%3BSchwan%2C+T+G%3BGaron%2C+C+F&rft.aulast=Dorward&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASM, 1325 Massachusetts Avenue NW, Washington, DC 20005, USA, Poster Paper No. C310 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New method for characterizing the motion of spermatozoa AN - 41599161; 3460574 AU - Dunson, D B AU - Weinberg, C R AU - Perreault, S D AU - Chapin, R E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41599161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+method+for+characterizing+the+motion+of+spermatozoa&rft.au=Dunson%2C+D+B%3BWeinberg%2C+C+R%3BPerreault%2C+S+D%3BChapin%2C+R+E&rft.aulast=Dunson&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of self ligands involved in negative selection of the T cell repertoire AN - 41596313; 2410762 AU - Vacchio AU - Ryan, J J AU - Hodes, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41596313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Analysis+of+self+ligands+involved+in+negative+selection+of+the+T+cell+repertoire&rft.au=Vacchio%3BRyan%2C+J+J%3BHodes%2C+R+J&rft.aulast=Vacchio&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15A, 1991 Poster Paper No. C 119 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of phosphotyrosine phosphatases in the activation of human T cells: Evidence that continues activity of a tyrosine phosphatase is required for TcR associated tyrosine kinase activity AN - 41595581; 2409258 AU - Fletcher, M C AU - Samelson, LE AU - June, CH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41595581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+phosphotyrosine+phosphatases+in+the+activation+of+human+T+cells%3A+Evidence+that+continues+activity+of+a+tyrosine+phosphatase+is+required+for+TcR+associated+tyrosine+kinase+activity&rft.au=Fletcher%2C+M+C%3BSamelson%2C+LE%3BJune%2C+CH&rft.aulast=Fletcher&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. D 214 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of 2-year inhalation exposure to glutaraldehyde in rats and mice AN - 41595568; 3460376 AU - Van Birgelen, APJM AU - Chou, B J AU - Renne, R A AU - Grumbein, S L AU - Roycroft, J AU - Hailey, R AU - Bucher, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41595568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+2-year+inhalation+exposure+to+glutaraldehyde+in+rats+and+mice&rft.au=Van+Birgelen%2C+APJM%3BChou%2C+B+J%3BRenne%2C+R+A%3BGrumbein%2C+S+L%3BRoycroft%2C+J%3BHailey%2C+R%3BBucher%2C+J+R&rft.aulast=Van+Birgelen&rft.aufirst=APJM&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1608 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Females have lower metabolic rates than males even after adjusting for differences in body weight and composition AN - 41594546; 2527872 AU - Ferraro, R AU - Lillioja, S AU - Fontvielle, A M AU - Rising, R AU - Ravussin, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41594546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Females+have+lower+metabolic+rates+than+males+even+after+adjusting+for+differences+in+body+weight+and+composition&rft.au=Ferraro%2C+R%3BLillioja%2C+S%3BFontvielle%2C+A+M%3BRising%2C+R%3BRavussin%2C+E&rft.aulast=Ferraro&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGF alpha is a potential mediator of estrogen action in the mouse uterus AN - 41594003; 2486341 AU - Nelson, K AU - Takahashi, T AU - Lee, D AU - Luetteke, N AU - Bossert, N AU - Eitzman, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41594003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=TGF+alpha+is+a+potential+mediator+of+estrogen+action+in+the+mouse+uterus&rft.au=Nelson%2C+K%3BTakahashi%2C+T%3BLee%2C+D%3BLuetteke%2C+N%3BBossert%2C+N%3BEitzman%2C+B&rft.aulast=Nelson&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. Q 420 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coordinate, pretranslational expression of pyruvate dehydrogenase complex during adipocyte differentiation AN - 41593717; 2517114 AU - Huh, T L AU - Huh, J W AU - Veech, R L AU - Song, B J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41593717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Coordinate%2C+pretranslational+expression+of+pyruvate+dehydrogenase+complex+during+adipocyte+differentiation&rft.au=Huh%2C+T+L%3BHuh%2C+J+W%3BVeech%2C+R+L%3BSong%2C+B+J&rft.aulast=Huh&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Requirements for pertussis toxin-catalyzed ADP-ribosylation of guanine nucleotide-binding proteins: Effects of in vitro mutagenesis at the carboxyterminus of G sub(0 alpha ) AN - 41593106; 2514256 AU - Avigan, J AU - Murtach, JJ Jr AU - Stevens, LA AU - Angus, C W AU - Moss, J AU - Vaughan, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41593106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Requirements+for+pertussis+toxin-catalyzed+ADP-ribosylation+of+guanine+nucleotide-binding+proteins%3A+Effects+of+in+vitro+mutagenesis+at+the+carboxyterminus+of+G+sub%280+alpha+%29&rft.au=Avigan%2C+J%3BMurtach%2C+JJ+Jr%3BStevens%2C+LA%3BAngus%2C+C+W%3BMoss%2C+J%3BVaughan%2C+M&rft.aulast=Avigan&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a trifluoroacetylated (TFA) 80 kDa protein as the endoplasmic reticulum protein ERp72 that is recognized by antibodies from halothane hepatitis patients AN - 41590082; 2433842 AU - Pumford, N R AU - Martin, B M AU - Thomassen, D AU - Martin, J L AU - Pohl, L R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41590082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+a+trifluoroacetylated+%28TFA%29+80+kDa+protein+as+the+endoplasmic+reticulum+protein+ERp72+that+is+recognized+by+antibodies+from+halothane+hepatitis+patients&rft.au=Pumford%2C+N+R%3BMartin%2C+B+M%3BThomassen%2C+D%3BMartin%2C+J+L%3BPohl%2C+L+R&rft.aulast=Pumford&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th Street, NW, Suite 1100, Washington, DC 20005, USA. 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Fax: (202) 371-1090., Paper No. 1031 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH funding and training opportunities for women in reproductive immunology AN - 41588507; 3462996 AU - Vogel, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41588507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=NIH+funding+and+training+opportunities+for+women+in+reproductive+immunology&rft.au=Vogel%2C+D&rft.aulast=Vogel&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Munksgaard International Publishers Ltd., Norre Sogade 35, P.O. Box 2148, Copenhagen DK-1016, Denmark, Abstracts available. Contact Munksgaard for price. Paper No. I-24 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel coupling of angiotensin II and beta-adrenergic receptors to adenylate cyclase in rat fetal fibroblasts AN - 41586654; 2415824 AU - Johnson, M C AU - Aguilera, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41586654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Novel+coupling+of+angiotensin+II+and+beta-adrenergic+receptors+to+adenylate+cyclase+in+rat+fetal+fibroblasts&rft.au=Johnson%2C+M+C%3BAguilera%2C+G&rft.aulast=Johnson&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. E213 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular characterization of rat liver epithelial cell lines transformed by aflatoxin B1 AN - 41586588; 2508524 AU - Hampson, L L AU - Silverman, JA AU - Luo, L AU - Thorgeirsson, S S AU - Wirth, P J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41586588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+characterization+of+rat+liver+epithelial+cell+lines+transformed+by+aflatoxin+B1&rft.au=Hampson%2C+L+L%3BSilverman%2C+JA%3BLuo%2C+L%3BThorgeirsson%2C+S+S%3BWirth%2C+P+J&rft.aulast=Hampson&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Crevice corrosion model for lap joint of aircraft AN - 41585105; 3457637 AU - Zheng, Xuejin Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41585105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Crevice+corrosion+model+for+lap+joint+of+aircraft&rft.au=Zheng%2C+Xuejin&rft.aulast=Zheng&rft.aufirst=Xuejin&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: NACE International, P.O. Box 218340, Houston, TX 77218-8340, USA; phone: 281-228-6214; fax: 281-228-6314; email: paula@mail.nace.org; URL: www.nace.org, Full papers available. Priced individually $7 (member) or $8 (non-member); complete set $725 (member) or $825 (non-member). Paper No. 99502 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathology and toxicology associated with chemical carcinogen treatment of transgenic mice carrying oncogenes AN - 41583063; 2429547 AU - Tennant, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41583063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pathology+and+toxicology+associated+with+chemical+carcinogen+treatment+of+transgenic+mice+carrying+oncogenes&rft.au=Tennant%2C+R&rft.aulast=Tennant&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th Street, NW, Suite 1100, Washington, DC 20005, USA. Telephone: (202) 371-1393. Fax: (202) 371-1090., Paper No. 7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence for polymeric forms of G alpha -proteins; A new view of the dynamic actions of GTP and hormones AN - 41581524; 2410515 AU - Nakamura, Shun-Ichi AU - Rodbell, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41581524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evidence+for+polymeric+forms+of+G+alpha+-proteins%3B+A+new+view+of+the+dynamic+actions+of+GTP+and+hormones&rft.au=Nakamura%2C+Shun-Ichi%3BRodbell%2C+M&rft.aulast=Nakamura&rft.aufirst=Shun-Ichi&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Energy expenditure of elite female runners measured by respiratory chamber and doubly labeled water AN - 41581464; 2498402 AU - Schulz, LO AU - Alger, S AU - Harper, I AU - Wilmore, J H AU - Ravussin, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41581464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Energy+expenditure+of+elite+female+runners+measured+by+respiratory+chamber+and+doubly+labeled+water&rft.au=Schulz%2C+LO%3BAlger%2C+S%3BHarper%2C+I%3BWilmore%2C+J+H%3BRavussin%2C+E&rft.aulast=Schulz&rft.aufirst=LO&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of lambda N gene expression AN - 41579470; 2426536 AU - Court, D AU - Fernandez, L AU - Kameyama, L AU - Guarneros, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41579470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+lambda+N+gene+expression&rft.au=Court%2C+D%3BFernandez%2C+L%3BKameyama%2C+L%3BGuarneros%2C+G&rft.aulast=Court&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15D, 1991; ISSN: 0730-2312 Poster Paper No. K 406 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tyrosine phosphorylation of p34 cdc2 in vitro by an associated tyrosine kinase: Correlation with function AN - 41578740; 2409893 AU - Ferris, D K AU - Kelvin, D J AU - White, G A AU - Li, Chou-Chi AU - Longo, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41578740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tyrosine+phosphorylation+of+p34+cdc2+in+vitro+by+an+associated+tyrosine+kinase%3A+Correlation+with+function&rft.au=Ferris%2C+D+K%3BKelvin%2C+D+J%3BWhite%2C+G+A%3BLi%2C+Chou-Chi%3BLongo%2C+D+L&rft.aulast=Ferris&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. D 511 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and characterization of a phosphotyrosine phosphatase gene expressed in mouse embryo AN - 41577994; 2415902 AU - Tremblay, M L AU - Mosinger, B AU - Tillmann, U AU - Westphal, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41577994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+and+characterization+of+a+phosphotyrosine+phosphatase+gene+expressed+in+mouse+embryo&rft.au=Tremblay%2C+M+L%3BMosinger%2C+B%3BTillmann%2C+U%3BWestphal%2C+H&rft.aulast=Tremblay&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. E225 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fluctuation analysis of v-Ha-ras transformed human bronchial epithelial cells AN - 41577588; 2427286 AU - Forrester, K AU - Kispert, J AU - Klein-Szanto, A AU - Linnainmaa, K AU - Gerwin, B I AU - Harris, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41577588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Fluctuation+analysis+of+v-Ha-ras+transformed+human+bronchial+epithelial+cells&rft.au=Forrester%2C+K%3BKispert%2C+J%3BKlein-Szanto%2C+A%3BLinnainmaa%2C+K%3BGerwin%2C+B+I%3BHarris%2C+C+C&rft.aulast=Forrester&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15D, 1991; ISSN: 0730-2312 Poster Paper No. J 308 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Secondary structure analysis confirms the presence of IRE stem loops in transferrin receptor mRNA AN - 41576820; 2426338 AU - Horowitz, JA AU - Casey, J L AU - Klausner, R D AU - Harford, J B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41576820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Secondary+structure+analysis+confirms+the+presence+of+IRE+stem+loops+in+transferrin+receptor+mRNA&rft.au=Horowitz%2C+JA%3BCasey%2C+J+L%3BKlausner%2C+R+D%3BHarford%2C+J+B&rft.aulast=Horowitz&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15D, 1991; ISSN: 0730-2312 Poster Paper No. K 329 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Copper inhibits the HIV-1 protease by both oxygen-dependent and oxygen-independent mechanisms AN - 41575603; 2491283 AU - Karlstroem, A R AU - Levine, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41575603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Copper+inhibits+the+HIV-1+protease+by+both+oxygen-dependent+and+oxygen-independent+mechanisms&rft.au=Karlstroem%2C+A+R%3BLevine%2C+R+L&rft.aulast=Karlstroem&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential expression of two nonmuscle myosin heavy chains in chicken and human cells AN - 41575415; 2412606 AU - Kawamoto, S AU - Adelstein, R S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41575415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+expression+of+two+nonmuscle+myosin+heavy+chains+in+chicken+and+human+cells&rft.au=Kawamoto%2C+S%3BAdelstein%2C+R+S&rft.aulast=Kawamoto&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15C, 1991 Poster Paper No. F 421 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transactivation by the HPV16 E7 protein is mediated through the E2F transcription factor AN - 41574860; 2438557 AU - Phelps, W C AU - Bagchi, S AU - Barnes, JA AU - Raychaudhuri, P AU - Munger, K AU - Howley, P M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41574860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transactivation+by+the+HPV16+E7+protein+is+mediated+through+the+E2F+transcription+factor&rft.au=Phelps%2C+W+C%3BBagchi%2C+S%3BBarnes%2C+JA%3BRaychaudhuri%2C+P%3BMunger%2C+K%3BHowley%2C+P+M&rft.aulast=Phelps&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15E, 1991; ISSN: 0730-2312 Poster Paper No. M 227 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of a milk protein gene AN - 41573777; 2414156 AU - Hennighausen, L AU - Burdon, T AU - McKnight, R AU - Shamay, A AU - Sankaran, L AU - Wall, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41573777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+a+milk+protein+gene&rft.au=Hennighausen%2C+L%3BBurdon%2C+T%3BMcKnight%2C+R%3BShamay%2C+A%3BSankaran%2C+L%3BWall%2C+R&rft.aulast=Hennighausen&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15A, 1991 Paper No. B 026 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a possible repressor of IL-2 gene transcription AN - 41573337; 2456727 AU - Kang, S-M AU - Grilli, M AU - Tran, A-C AU - Lenardo, MJ Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41573337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+a+possible+repressor+of+IL-2+gene+transcription&rft.au=Kang%2C+S-M%3BGrilli%2C+M%3BTran%2C+A-C%3BLenardo%2C+MJ&rft.aulast=Kang&rft.aufirst=S-M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lymphokines released by activated or HTLV infected T cells induce growth of normal mesenchymal cell and of cells derived from Kaposi's sarcoma lesions of AIDS patients AN - 41572927; 2455655 AU - Barillari, G AU - Buonaguro, L AU - Fiorelli, V AU - Gallo, R C AU - Ensoli, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41572927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preferential+in+vivo+inhibition+of+the+slow+component+of+alpha+adrenoceptor+activation+by+rat+atrial+natriuretic+factor&rft.au=Haass%2C+M%3BGoldstein%2C+D+S%3BKopin%2C+I+J%3BZukowska-Grojec%2C+Z&rft.aulast=Haass&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. P 202 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of activated N-ras oncogenes in C57BL/6 X C3H/He mouse liver tumors induced by ciprofibrate a potent peroxisome proliferator AN - 41572903; 2409421 AU - Hegi, ME AU - Fox, T R AU - Belinsky, SA AU - Anderson, M W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41572903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Detection+of+activated+N-ras+oncogenes+in+C57BL%2F6+X+C3H%2FHe+mouse+liver+tumors+induced+by+ciprofibrate+a+potent+peroxisome+proliferator&rft.au=Hegi%2C+ME%3BFox%2C+T+R%3BBelinsky%2C+SA%3BAnderson%2C+M+W&rft.aulast=Hegi&rft.aufirst=ME&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. D 317 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of autocrine IL-6 and TNF- alpha production in human B cell function AN - 41572679; 2501587 AU - Kozlow, E J AU - Kehrl, J H AU - Fauci, A S AU - Rieckmann, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41572679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+autocrine+IL-6+and+TNF-+alpha+production+in+human+B+cell+function&rft.au=Kozlow%2C+E+J%3BKehrl%2C+J+H%3BFauci%2C+A+S%3BRieckmann%2C+P&rft.aulast=Kozlow&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts, FASEB Journal N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SANS studies of microtubule protofilament numbers AN - 41572264; 3444995 AU - Sackett, D AU - Chernomordik, V AU - Krueger, S AU - Nossal, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41572264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=SANS+studies+of+microtubule+protofilament+numbers&rft.au=Sackett%2C+D%3BChernomordik%2C+V%3BKrueger%2C+S%3BNossal%2C+R&rft.aulast=Sackett&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular analysis of the state of T cell clonal anergy AN - 41572003; 2410620 AU - Schwartz, R H AU - Kang, S AU - Beverly, B AU - Brorson, K AU - Mueller, D AU - Lenardo, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41572003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+analysis+of+the+state+of+T+cell+clonal+anergy&rft.au=Schwartz%2C+R+H%3BKang%2C+S%3BBeverly%2C+B%3BBrorson%2C+K%3BMueller%2C+D%3BLenardo%2C+M&rft.aulast=Schwartz&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15A, 1991 Paper No. C 006 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Applications of molecular modeling and density functional theory for the design of retroviral nucleocapsid zinc finger inhibitors AN - 41568840; 3445156 AU - Maynard, A AU - Covell, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41568840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Applications+of+molecular+modeling+and+density+functional+theory+for+the+design+of+retroviral+nucleocapsid+zinc+finger+inhibitors&rft.au=Maynard%2C+A%3BCovell%2C+D&rft.aulast=Maynard&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Signal transduction through the high affinity IgE receptor is mediated by the lyn or yes tyrosine protein kinases AN - 41568637; 2409601 AU - Eiseman, E AU - Bolen, J B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41568637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Signal+transduction+through+the+high+affinity+IgE+receptor+is+mediated+by+the+lyn+or+yes+tyrosine+protein+kinases&rft.au=Eiseman%2C+E%3BBolen%2C+J+B&rft.aulast=Eiseman&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. D 413 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biochemical characterization of the human papillomavirus E6-P53 complex AN - 41568439; 2438514 AU - Huibregtse, J M AU - Scheffner, M AU - Howley, P M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41568439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biochemical+characterization+of+the+human+papillomavirus+E6-P53+complex&rft.au=Huibregtse%2C+J+M%3BScheffner%2C+M%3BHowley%2C+P+M&rft.aulast=Huibregtse&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15E, 1991; ISSN: 0730-2312 Poster Paper No. M 214 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure function analysis of the T cell antigen receptor AN - 41568218; 2408897 AU - Klausner, R D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41568218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structure+function+analysis+of+the+T+cell+antigen+receptor&rft.au=Klausner%2C+R+D&rft.aulast=Klausner&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Paper No. D 019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human line-1 (L1Hs) element: Identification and analysis of it's internal promoter AN - 41567376; 2428840 AU - Swergold, G D AU - Singer, M F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41567376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+line-1+%28L1Hs%29+element%3A+Identification+and+analysis+of+it%27s+internal+promoter&rft.au=Swergold%2C+G+D%3BSinger%2C+M+F&rft.aulast=Swergold&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15D, 1991; ISSN: 0730-2312 Poster Paper No. I 220 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activated signal transduction pathway generates heat in confined intracellular compartments AN - 41566881; 3445786 AU - Zohar, O AU - Pacini, A AU - Tandon, A AU - Yoshioka, T AU - Alkon, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41566881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=NIH+funding+and+training+opportunities+for+women+in+reproductive+immunology&rft.au=Vogel%2C+D&rft.aulast=Vogel&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional effects of anti-CD4 antibody treatment on self-reactive cells frscued from intrathymic deletion AN - 41566815; 2411333 AU - Roberts, J L AU - Sheard, M AU - Sharrow, SO AU - Singer, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41566815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Functional+effects+of+anti-CD4+antibody+treatment+on+self-reactive+cells+frscued+from+intrathymic+deletion&rft.au=Roberts%2C+J+L%3BSheard%2C+M%3BSharrow%2C+SO%3BSinger%2C+A&rft.aulast=Roberts&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15A, 1991 Poster Paper No. C 349 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coordinate post-transcriptional regulation of ferritin and transferrin receptor expression AN - 41566192; 2426017 AU - Klausner, R D AU - Harford, J B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41566192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Coordinate+post-transcriptional+regulation+of+ferritin+and+transferrin+receptor+expression&rft.au=Klausner%2C+R+D%3BHarford%2C+J+B&rft.aulast=Klausner&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15D, 1991; ISSN: 0730-2312 Paper No. K 025 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - N-myc antisense restricts the differentiation potential of neuroectodermal cell lines AN - 41566161; 2429255 AU - Neckers, L M AU - Rosolen, A AU - Whitesell, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41566161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=N-myc+antisense+restricts+the+differentiation+potential+of+neuroectodermal+cell+lines&rft.au=Neckers%2C+L+M%3BRosolen%2C+A%3BWhitesell%2C+L&rft.aulast=Neckers&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dept., 7th Floor, 605 Third Avenue, New York, NY 10158, USA., Journal of Cellular Biochemistry; Supplement 15D, 1991; ISSN: 0730-2312 Paper No. CD 017 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-tumorigenic human liver epithelial cell cultures for chemical and biological carcinogenesis investigations AN - 41566086; 2427501 AU - Lechner, J F AU - Smoot, D T AU - Pfeifer, AAMA AU - Cole, KE AU - Weston, A AU - Groopman, J D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41566086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Non-tumorigenic+human+liver+epithelial+cell+cultures+for+chemical+and+biological+carcinogenesis+investigations&rft.au=Lechner%2C+J+F%3BSmoot%2C+D+T%3BPfeifer%2C+AAMA%3BCole%2C+KE%3BWeston%2C+A%3BGroopman%2C+J+D&rft.aulast=Lechner&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15D, 1991; ISSN: 0730-2312 Poster Paper No. J 413 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contrasting the low pH-dependent conformational modification of X:31 and Japan influenza hemagglutinin AN - 41565972; 3446763 AU - Markovic, I AU - Leikina, E A AU - Chernomordik, LV Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41565972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Contrasting+the+low+pH-dependent+conformational+modification+of+X%3A31+and+Japan+influenza+hemagglutinin&rft.au=Markovic%2C+I%3BLeikina%2C+E+A%3BChernomordik%2C+LV&rft.aulast=Markovic&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overview of K-12 environmental health science education efforts at NIEHS AN - 41564747; 3459947 AU - Dearry, A AU - Yost, G S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41564747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Overview+of+K-12+environmental+health+science+education+efforts+at+NIEHS&rft.au=Dearry%2C+A%3BYost%2C+G+S&rft.aulast=Dearry&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Paper No. 1179 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of mutation spectra to compare one-electron and two-electron pathways of benzo[a]pyrene (BAP) activation AN - 41563616; 3458838 AU - Watson, DE AU - Tindall, K R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41563616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+mutation+spectra+to+compare+one-electron+and+two-electron+pathways+of+benzo%5Ba%5Dpyrene+%28BAP%29+activation&rft.au=Watson%2C+DE%3BTindall%2C+K+R&rft.aulast=Watson&rft.aufirst=DE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Paper No. 70 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural analysis of the otoconial matrix of the frog and guinea pig vestibular sensory organs AN - 41560619; 3439502 AU - Lins, U AU - Farina, M AU - Kurc, M AU - Kachar, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41560619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structural+analysis+of+the+otoconial+matrix+of+the+frog+and+guinea+pig+vestibular+sensory+organs&rft.au=Lins%2C+U%3BFarina%2C+M%3BKurc%2C+M%3BKachar%2C+B&rft.aulast=Lins&rft.aufirst=U&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 2053 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of the three-dimensional structure of interleukin-1 beta in solution at high resolution: Applications of three and four dimensional heteronuclear NMR AN - 41560147; 2483412 AU - Clore, G M AU - Gronenborn, A M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41560147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Determination+of+the+three-dimensional+structure+of+interleukin-1+beta+in+solution+at+high+resolution%3A+Applications+of+three+and+four+dimensional+heteronuclear+NMR&rft.au=Clore%2C+G+M%3BGronenborn%2C+A+M&rft.aulast=Clore&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15G, 1991; ISSN: 0730-2312 Paper No. CG 010 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of critical, conserved residues in mammalian and bacterial ADP-ribosylarginine hydrolases AN - 41559812; 3439515 AU - Konczalik, P AU - Moss, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41559812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+critical%2C+conserved+residues+in+mammalian+and+bacterial+ADP-ribosylarginine+hydrolases&rft.au=Konczalik%2C+P%3BMoss%2C+J&rft.aulast=Konczalik&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. 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Paper No. 2066 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variation in Ah receptor expression and cytochrome P450 inducibility in a dioxin-exposed population AN - 41559692; 3460213 AU - Masten, SA AU - Grassman, JA AU - Miller, C R AU - Spencer, D L AU - Jung, D AU - Edler, L AU - Needham, L L AU - Lucier, G W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41559692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Variation+in+Ah+receptor+expression+and+cytochrome+P450+inducibility+in+a+dioxin-exposed+population&rft.au=Masten%2C+SA%3BGrassman%2C+JA%3BMiller%2C+C+R%3BSpencer%2C+D+L%3BJung%2C+D%3BEdler%2C+L%3BNeedham%2C+L+L%3BLucier%2C+G+W&rft.aulast=Masten&rft.aufirst=SA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. 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Paper No. 1445 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strain analysis of conformation change AN - 41558727; 2482823 AU - Harrison, R W AU - Andrews, L C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41558727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Strain+analysis+of+conformation+change&rft.au=Harrison%2C+R+W%3BAndrews%2C+L+C&rft.aulast=Harrison&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15G, 1991; ISSN: 0730-2312 Poster Paper No. R 141 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Solid phase assay for peptide alpha -amidating activity AN - 41555578; 2487810 AU - Scott, F M AU - Treston, A M AU - Eipper, BA AU - Avis, I AU - Gazdar, A F AU - Cuttitta, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41555578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Solid+phase+assay+for+peptide+alpha+-amidating+activity&rft.au=Scott%2C+F+M%3BTreston%2C+A+M%3BEipper%2C+BA%3BAvis%2C+I%3BGazdar%2C+A+F%3BCuttitta%2C+F&rft.aulast=Scott&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Dep., 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Chemistry; Supplement 15F, 1991; ISSN: 0730-2312 Poster Paper No. CE 405 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abnormal zona pellucida and decreased fertility in mice lacking ZP1 AN - 41555270; 3439251 AU - Rankin, T L AU - Talbot, P AU - Lee, E AU - Dean, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41555270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Abnormal+zona+pellucida+and+decreased+fertility+in+mice+lacking+ZP1&rft.au=Rankin%2C+T+L%3BTalbot%2C+P%3BLee%2C+E%3BDean%2C+J&rft.aulast=Rankin&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. 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Paper No. 1802 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ESR spin-trapping investigation of reaction of mitochondrial cytochrome C oxidase with H2O2.: 07C 09C AN - 41553896; 3445310 AU - Chen, Y-R AU - Gunther, M R AU - Mason, R P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41553896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=ESR+spin-trapping+investigation+of+reaction+of+mitochondrial+cytochrome+C+oxidase+with+H2O2.%3A+07C+09C&rft.au=Chen%2C+Y-R%3BGunther%2C+M+R%3BMason%2C+R+P&rft.aulast=Chen&rft.aufirst=Y-R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transgenic mouse AN - 41552894; 2420151 AU - Westphal, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:MUTIDISCIPLINARY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41552894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transgenic+mouse&rft.au=Westphal%2C+H&rft.aulast=Westphal&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AAAS Books, Dept. A33, P.O. Box 753, Waldorf, MD 20604, USA. Telephone: (301) 645-5643 ask for AAAS. Fax: (301) 843-0159., Abstracts, 91-02, $8.00 members/$10.00 non-members plus $4.00 postage/handling N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ATP-dependent and ATP-independent mechanisms of entry by Chlamydia trachomatis in HeLa cells AN - 41551378; 3438919 AU - Carabeo, R A AU - Hackstadt, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41551378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=ATP-dependent+and+ATP-independent+mechanisms+of+entry+by+Chlamydia+trachomatis+in+HeLa+cells&rft.au=Carabeo%2C+R+A%3BHackstadt%2C+T&rft.aulast=Carabeo&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 1470 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a candidate tumor metastasis suppressor gene, nm23 AN - 41549224; 2426768 AU - Steeg, P S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41549224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+basis+for+ligand+antagonism&rft.au=Torigoe%2C+C%3BInman%2C+J+K%3BMetzger%2C+H&rft.aulast=Torigoe&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., Subscription Department, 7th Floor, 605 Third Avenue, New York, NY 10158, USA, Journal of Cellular Biochemistry; Supplement 15D, 1991; ISSN: 0730-2312 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temporal transcript expression from Chlamydial trachomatis inclusion membrane protein genes AN - 41548181; 3440360 AU - Shaw, E I AU - Scidmore-Carlson, MA AU - Hackstadt, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41548181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Temporal+transcript+expression+from+Chlamydial+trachomatis+inclusion+membrane+protein+genes&rft.au=Shaw%2C+E+I%3BScidmore-Carlson%2C+MA%3BHackstadt%2C+T&rft.aulast=Shaw&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 2911 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered expression and regulation of retinoic acid receptor gamma mRNA in a RA-nonresponsive embryonal carcinoma mutant cell line AN - 41546809; 2416283 AU - Nervi, C AU - Voliberg, T M AU - George, MD AU - Grippo, J F AU - Jetten, A M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41546809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Altered+expression+and+regulation+of+retinoic+acid+receptor+gamma+mRNA+in+a+RA-nonresponsive+embryonal+carcinoma+mutant+cell+line&rft.au=Nervi%2C+C%3BVoliberg%2C+T+M%3BGeorge%2C+MD%3BGrippo%2C+J+F%3BJetten%2C+A+M&rft.aulast=Nervi&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. E331 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular organization of the mechanism of outer hair cell electromotility AN - 41546128; 3437646 AU - Kachar, B AU - Belyantseva, I AU - Frolenkov, G AU - Riordan, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41546128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+organization+of+the+mechanism+of+outer+hair+cell+electromotility&rft.au=Kachar%2C+B%3BBelyantseva%2C+I%3BFrolenkov%2C+G%3BRiordan%2C+G&rft.aulast=Kachar&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 197 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decoupling of brevetoxin's four distinct physiological effects on voltage-gated sodium channels by site-directed toxin derivatization AN - 41546045; 3460109 AU - Baden, D G AU - Rein, K S AU - Adams, D J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41546045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prevalence+of+Mitral+Annular+and+Submitral+Calcification+and+Their+Relation+to+Cardiovascular+Risk+Factors+in+a+General+Free-Living+Population+-+Preliminary+Findings%3A+The+Framingham+Study&rft.au=Savage%2C+D+D%3BGarrison%2C+R+J%3BCastelli%2C+W+P%3BMcNamara%2C+P+M%3BAnderson%2C+S+J%3BKannel%2C+W+B&rft.aulast=Savage&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, USA, Abstracts available. Price $50. Poster Paper No. 1341 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trafficking and targeting studies of a unique surface enzyme in the parasitic protozoan Leishmania donovani using green fluorescent protein chimeras AN - 41541615; 3438928 AU - Ghedin, E AU - Debrabant, A AU - Dwyer, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41541615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Trafficking+and+targeting+studies+of+a+unique+surface+enzyme+in+the+parasitic+protozoan+Leishmania+donovani+using+green+fluorescent+protein+chimeras&rft.au=Ghedin%2C+E%3BDebrabant%2C+A%3BDwyer%2C+D&rft.aulast=Ghedin&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 1479 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stimulation of protein synthesis by internalized insulin AN - 41540551; 2415982 AU - Miller, D S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41540551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stimulation+of+protein+synthesis+by+internalized+insulin&rft.au=Miller%2C+D+S&rft.aulast=Miller&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. CB 128 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nuclear transport is inhibited by overexpression of O-linked N-acetylglucosaminyltransferase AN - 41539252; 3439319 AU - Love, D C AU - Prince, J M AU - Lubas, W B AU - Sweitzer, T D AU - Wu, W AU - Hanover, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41539252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Nuclear+transport+is+inhibited+by+overexpression+of+O-linked+N-acetylglucosaminyltransferase&rft.au=Love%2C+D+C%3BPrince%2C+J+M%3BLubas%2C+W+B%3BSweitzer%2C+T+D%3BWu%2C+W%3BHanover%2C+JA&rft.aulast=Love&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 1870 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation of type VI nestin from BHK-21 cells: Co-assembly in vitro with type III vimentin and type IV a-internexin to form heterodimer coiled-coil molecules and intermediate filaments AN - 41539202; 3437700 AU - Steinert, P M AU - Jang, S-J AU - Wu, K AU - Marekov, L N AU - Parry, DAD AU - Prahlad, V AU - Chou, Y-H AU - Goldman, R D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41539202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evidence+for+thromboxane+biosynthesis+in+a+human+lung+adenocarcinoma+cell+line%2C+A549&rft.au=Hubbard%2C+W+C%3BAlley%2C+M+C%3BMcLemore%2C+T+L%3BBoyd%2C+M+R&rft.aulast=Hubbard&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 251 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overall response to enzyme replacement therapy (ERT) in type III gaucher with aggressive systemic disease AN - 41538386; 3430699 AU - Altarescu, G AU - Kaneski, C R AU - Kreps, C AU - Barton, N W AU - Schiffmann, R AU - Zimran, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41538386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Overall+response+to+enzyme+replacement+therapy+%28ERT%29+in+type+III+gaucher+with+aggressive+systemic+disease&rft.au=Altarescu%2C+G%3BKaneski%2C+C+R%3BKreps%2C+C%3BBarton%2C+N+W%3BSchiffmann%2C+R%3BZimran%2C+A&rft.aulast=Altarescu&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: W.B. Saunders Co., P.O. Box 628239, Orlando, FL 32862-8239, USA; phone: (800) 654-2452; fax: (800) 225-6030; email: wbspcs@harcourtbrave.com; URL: customerservice.wbsaunders.com, Abstracts available. Contact W.B. Saunders for price. Poster Paper No. 68 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of the insulin receptor gene during adipocyte differentiation AN - 41537165; 2415962 AU - McKeon, C AU - Pham, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41537165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+the+insulin+receptor+gene+during+adipocyte+differentiation&rft.au=McKeon%2C+C%3BPham%2C+T&rft.aulast=McKeon&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15B, 1991 Poster Paper No. CA 108 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microdomain formation in polyunsaturated lipid bilayer assemblies: Infrared spectroscopic studies of didocosahexaenoylphosphatidylcholine (DDPC) and disteroylphosphatidylcholine (DSPC-D70) binary mixtures AN - 41536106; 3444932 AU - Wang, H AU - McCarthy, P K AU - Litman, B J AU - Levin, I W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41536106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Microdomain+formation+in+polyunsaturated+lipid+bilayer+assemblies%3A+Infrared+spectroscopic+studies+of+didocosahexaenoylphosphatidylcholine+%28DDPC%29+and+disteroylphosphatidylcholine+%28DSPC-D70%29+binary+mixtures&rft.au=Wang%2C+H%3BMcCarthy%2C+P+K%3BLitman%2C+B+J%3BLevin%2C+I+W&rft.aulast=Wang&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inducible expression of Hox 1.3 homeodomain protein in transgenic mice AN - 41533342; 2415795 AU - Odenwald, W F AU - DeSanto, R J AU - Zhang, S-D AU - Vos, P AU - Arnheiter, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41533342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inducible+expression+of+Hox+1.3+homeodomain+protein+in+transgenic+mice&rft.au=Odenwald%2C+W+F%3BDeSanto%2C+R+J%3BZhang%2C+S-D%3BVos%2C+P%3BArnheiter%2C+H&rft.aulast=Odenwald&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15A, 1991 Poster Paper No. B 120 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and expression of two nonmuscle myosin heavy chains in chicken tissues AN - 41532769; 2412684 AU - Takahashi, M AU - Kawamoto, S AU - Adelstein, R S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41532769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+and+expression+of+two+nonmuscle+myosin+heavy+chains+in+chicken+tissues&rft.au=Takahashi%2C+M%3BKawamoto%2C+S%3BAdelstein%2C+R+S&rft.aulast=Takahashi&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Wiley & Sons, Inc., 605 Third Avenue, 7th Floor, New York, NY 10158, USA, Journal of Cellular Biochemistry; ISSN: 0730-2312; Supplement 15C, 1991 Poster Paper No. F 443 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of telopeptides in collagen fibrillogenesis revisited. Pronase inhibits fibrillogenesis by cleaving the triple helix AN - 41528446; 3446278 AU - Kuznetsova, N AU - Leikin, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41528446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+telopeptides+in+collagen+fibrillogenesis+revisited.+Pronase+inhibits+fibrillogenesis+by+cleaving+the+triple+helix&rft.au=Kuznetsova%2C+N%3BLeikin%2C+S&rft.aulast=Kuznetsova&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transport of nucleotides through the mitochondrial channel, VDAC. Topic(s): 04C 05H AN - 41525692; 3444491 AU - Rostovtseva, T K AU - Bezrukov, S M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41525692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transport+of+nucleotides+through+the+mitochondrial+channel%2C+VDAC.+Topic%28s%29%3A+04C+05H&rft.au=Rostovtseva%2C+T+K%3BBezrukov%2C+S+M&rft.aulast=Rostovtseva&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maintenance of the mitochondrial genome by the human DNA polymerase gamma AN - 41516797; 3439683 AU - Copeland, W C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41516797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Maintenance+of+the+mitochondrial+genome+by+the+human+DNA+polymerase+gamma&rft.au=Copeland%2C+W+C&rft.aulast=Copeland&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 2234 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Folding and membrane interaction of the amphipathic peptide P828S from HIV-1 GP41 AN - 41516625; 3445741 AU - Koenig, B W AU - Ferretti, JA AU - Gawrisch, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41516625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Folding+and+membrane+interaction+of+the+amphipathic+peptide+P828S+from+HIV-1+GP41&rft.au=Koenig%2C+B+W%3BFerretti%2C+JA%3BGawrisch%2C+K&rft.aulast=Koenig&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Biophysical Society, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7114; fax: (301) 530-7133; email: society@biophysics.faseb.org; URL: www.biophysics.faseb.org, Abstracts available. Price $25. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of neurotransmitter receptors regulates cell cycle progression and differentiation of oligodendrocyte progenitors AN - 41514814; 3439591 AU - Ghiani, CA AU - Eisen, A M AU - Yuan, X AU - McBain, C J AU - Gallo, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41514814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Activation+of+neurotransmitter+receptors+regulates+cell+cycle+progression+and+differentiation+of+oligodendrocyte+progenitors&rft.au=Ghiani%2C+CA%3BEisen%2C+A+M%3BYuan%2C+X%3BMcBain%2C+C+J%3BGallo%2C+V&rft.aulast=Ghiani&rft.aufirst=CA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 2142 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of three novel Chlamydia trachomatis inclusion membrane proteins AN - 41514514; 3440355 AU - Scidmore-Carlson, MA AU - Shaw, E I AU - Dooley, CA AU - Fischer, E R AU - Hackstadt, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41514514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+three+novel+Chlamydia+trachomatis+inclusion+membrane+proteins&rft.au=Scidmore-Carlson%2C+MA%3BShaw%2C+E+I%3BDooley%2C+CA%3BFischer%2C+E+R%3BHackstadt%2C+T&rft.aulast=Scidmore-Carlson&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 2906 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impaired intracellular LDL cholesterol metabolism in Smith-Lemli-Optiz fibroblasts AN - 41510067; 3418339 AU - Porter, F D AU - Wassif, CA AU - Tsokos, M AU - Steiner, R D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41510067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Impaired+intracellular+LDL+cholesterol+metabolism+in+Smith-Lemli-Optiz+fibroblasts&rft.au=Porter%2C+F+D%3BWassif%2C+CA%3BTsokos%2C+M%3BSteiner%2C+R+D&rft.aulast=Porter&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Human Genetics, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 571-1825; email: subscriptions@journals.uchicago.edu, Abstracts available. Price $41.25. Poster Paper No. 1571 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transforming growth factor- beta suppresses AP-1 but not NF- Kappa B or Oct-2 in human B lymphocytes AN - 41507230; 2278087 AU - Kehrl, J H AU - Thevenin, C AU - Fauci, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41507230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transforming+growth+factor-+beta+suppresses+AP-1+but+not+NF-+Kappa+B+or+Oct-2+in+human+B+lymphocytes&rft.au=Kehrl%2C+J+H%3BThevenin%2C+C%3BFauci%2C+A+S&rft.aulast=Kehrl&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcriptional control of the human acid alpha-glucosidase gene by a silencer element within intron 1 AN - 41507125; 3417895 AU - Yan, B AU - Raben, N AU - Nichols, R AU - Plotz, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41507125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transcriptional+control+of+the+human+acid+alpha-glucosidase+gene+by+a+silencer+element+within+intron+1&rft.au=Yan%2C+B%3BRaben%2C+N%3BNichols%2C+R%3BPlotz%2C+P&rft.aulast=Yan&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Human Genetics, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 571-1825; email: subscriptions@journals.uchicago.edu, Abstracts available. Price $41.25. Poster Paper No. 1126 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of the mouse int-3 gene in normal and mammary tumor tissue AN - 41506821; 2293542 AU - Gallahan, D AU - Robbins, J AU - Blondel, B AU - Callahan, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41506821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+the+mouse+int-3+gene+in+normal+and+mammary+tumor+tissue&rft.au=Gallahan%2C+D%3BRobbins%2C+J%3BBlondel%2C+B%3BCallahan%2C+R&rft.aulast=Gallahan&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Foundation for Advanced Cancer Studies N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization and expression of a cDNA clone for calcineurin from the fungus, Neurospora crassa AN - 41506033; 2287908 AU - Higuchi, S AU - Tamura, J AU - Kincaid, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41506033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+and+expression+of+a+cDNA+clone+for+calcineurin+from+the+fungus%2C+Neurospora+crassa&rft.au=Higuchi%2C+S%3BTamura%2C+J%3BKincaid%2C+R+L&rft.aulast=Higuchi&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutant collagen synthesis, matrix incorporation and retention by cultured fibroblasts and osteoblasts from two OI type IV probands AN - 41505872; 3437786 AU - Forlino, A AU - Cabral, WA AU - Marini, J C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41505872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mutant+collagen+synthesis%2C+matrix+incorporation+and+retention+by+cultured+fibroblasts+and+osteoblasts+from+two+OI+type+IV+probands&rft.au=Forlino%2C+A%3BCabral%2C+WA%3BMarini%2C+J+C&rft.aulast=Forlino&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 530-7153; fax: (301) 530-7139; email: ascbinfo@ascb.org; URL: www.ascb.org/ascb/, Abstracts available. Price $45. Paper No. 337 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of p185 super(met) and its high molecular weight species AN - 41505593; 2293664 AU - Faletto, D L AU - Kmiecik, TE AU - Gonzatti, MI AU - Vande Woude, GF Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41505593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+p185+super%28met%29+and+its+high+molecular+weight+species&rft.au=Faletto%2C+D+L%3BKmiecik%2C+TE%3BGonzatti%2C+MI%3BVande+Woude%2C+GF&rft.aulast=Faletto&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Foundation for Advanced Cancer Studies N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evi-2, a common site of viral integration in murine myeloid tumors AN - 41505450; 2290795 AU - Buchberg, A M AU - Cawthon, R AU - Bedigian, H G AU - O'Connell, P AU - White, R AU - Jenkins, NA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41505450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evi-2%2C+a+common+site+of+viral+integration+in+murine+myeloid+tumors&rft.au=Buchberg%2C+A+M%3BCawthon%2C+R%3BBedigian%2C+H+G%3BO%27Connell%2C+P%3BWhite%2C+R%3BJenkins%2C+NA&rft.aulast=Buchberg&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Foundation for Advanced Cancer Studies N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reversibility of induction of terminal squamous differentiation of normal human bronchial epithelial cells by TGF- beta sub(1) AN - 41502349; 2257417 AU - Lechner, J F AU - Gerwin, B I AU - Ke, Y AU - Pfeifer, AMA AU - Ruskie, SE AU - Harris, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41502349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Reversibility+of+induction+of+terminal+squamous+differentiation+of+normal+human+bronchial+epithelial+cells+by+TGF-+beta+sub%281%29&rft.au=Lechner%2C+J+F%3BGerwin%2C+B+I%3BKe%2C+Y%3BPfeifer%2C+AMA%3BRuskie%2C+SE%3BHarris%2C+C+C&rft.aulast=Lechner&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Paper No. 5058 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of the self ligand(s) recognized by V beta 11 super(+) and V beta 12 super(+) cells AN - 41500412; 2270583 AU - Vacchio AU - Hodes, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41500412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Analysis+of+the+self+ligand%28s%29+recognized+by+V+beta+11+super%28%2B%29+and+V+beta+12+super%28%2B%29+cells&rft.au=Vacchio%3BHodes%2C+R+J&rft.aulast=Vacchio&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of a novel exonic X-chromosome dodecamer insertional variant allele with mental retardation AN - 41499898; 3418729 AU - Philibert, R A AU - King, B H AU - Winfield, SI AU - Cook, E H AU - Lee, Y-H AU - Stubblefield, B AU - Damschroder-Williams, P AU - Dea, C AU - Palotie, A AU - Tengstrom, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41499898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Association+of+a+novel+exonic+X-chromosome+dodecamer+insertional+variant+allele+with+mental+retardation&rft.au=Philibert%2C+R+A%3BKing%2C+B+H%3BWinfield%2C+SI%3BCook%2C+E+H%3BLee%2C+Y-H%3BStubblefield%2C+B%3BDamschroder-Williams%2C+P%3BDea%2C+C%3BPalotie%2C+A%3BTengstrom%2C+C&rft.aulast=Hiramatsu&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Human Genetics, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 571-1825; email: subscriptions@journals.uchicago.edu, Abstracts available. Price $41.25. Poster Paper No. 1961 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies with antigen and adenosine analogs indicate that exocytosis in RBL-2H3 cells is dependent on multiple G-proteins and sustained Ca super(2+)-influx AN - 41499686; 2256993 AU - Ali, H AU - Beaven, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41499686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Studies+with+antigen+and+adenosine+analogs+indicate+that+exocytosis+in+RBL-2H3+cells+is+dependent+on+multiple+G-proteins+and+sustained+Ca+super%282%2B%29-influx&rft.au=Ali%2C+H%3BBeaven%2C+MA&rft.aulast=Ali&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of messenger RNAs coding for the catalytic subunit of the calmodulin-dependent protein phosphatase, calcineurin AN - 41498872; 2287904 AU - Giri, PR AU - Kincaid, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41498872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+messenger+RNAs+coding+for+the+catalytic+subunit+of+the+calmodulin-dependent+protein+phosphatase%2C+calcineurin&rft.au=Giri%2C+PR%3BKincaid%2C+R+L&rft.aulast=Giri&rft.aufirst=PR&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiogenesis and hematopoiesis induced by KSHV-encoded interleukin-6 AN - 41498313; 3432472 AU - Aoki, Y AU - Jaffe, E S AU - Chang, Y AU - Jones, K AU - Teruya-Feldstein, J AU - Moore, P S AU - Tosato, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41498313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Angiogenesis+and+hematopoiesis+induced+by+KSHV-encoded+interleukin-6&rft.au=Aoki%2C+Y%3BJaffe%2C+E+S%3BChang%2C+Y%3BJones%2C+K%3BTeruya-Feldstein%2C+J%3BMoore%2C+P+S%3BTosato%2C+G&rft.aulast=Aoki&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: W.B. Saunders Co., P.O. Box 628239, Orlando, FL 32862-8239, USA; phone: (800) 654-2452; fax: (800) 225-6030; email: wbspcs@harcourtbrave.com; URL: customerservice.wbsaunders.com, Abstracts available. Contact W.B. Saunders for price. Poster Paper No. 1238 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies with forskolin indicate that interactions between G proteins and adenylate cyclase differ for cells and membranes AN - 41497704; 2275185 AU - Rebois, R V AU - Inoue, Y Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41497704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Studies+with+forskolin+indicate+that+interactions+between+G+proteins+and+adenylate+cyclase+differ+for+cells+and+membranes&rft.au=Rebois%2C+R+V%3BInoue%2C+Y&rft.aulast=Rebois&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biochemistry of a major, hormonally-regulated, phosphoprotein associated with the lipid storage droplet in adipocytes AN - 41497003; 2287837 AU - Greenberg, A S AU - Egan, J J AU - Wek, SA AU - Garty, N B AU - Moos, M C AU - Londos, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41497003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biochemistry+of+a+major%2C+hormonally-regulated%2C+phosphoprotein+associated+with+the+lipid+storage+droplet+in+adipocytes&rft.au=Greenberg%2C+A+S%3BEgan%2C+J+J%3BWek%2C+SA%3BGarty%2C+N+B%3BMoos%2C+M+C%3BLondos%2C+C&rft.aulast=Greenberg&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of mutant human class II MHC molecules: Sequences necessary for dimer assembly and toxin binding AN - 41496859; 2287608 AU - Karp AU - Teletski, CL AU - Scholl, PR AU - Geha, R AU - Long, E O Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41496859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Analysis+of+mutant+human+class+II+MHC+molecules%3A+Sequences+necessary+for+dimer+assembly+and+toxin+binding&rft.au=Karp%3BTeletski%2C+CL%3BScholl%2C+PR%3BGeha%2C+R%3BLong%2C+E+O&rft.aulast=Karp&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Linkage studies and mutational analysis of a family with a novel skin disorder AN - 41495728; 3418401 AU - Brown, T C AU - DiGiovanna, J J AU - Compton, J G AU - Fleckman, P AU - Bale, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41495728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Linkage+studies+and+mutational+analysis+of+a+family+with+a+novel+skin+disorder&rft.au=Brown%2C+T+C%3BDiGiovanna%2C+J+J%3BCompton%2C+J+G%3BFleckman%2C+P%3BBale%2C+S+J&rft.aulast=Brown&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Human Genetics, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 571-1825; email: subscriptions@journals.uchicago.edu, Abstracts available. 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Poster Paper No. 1633 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence for regulation of the adipocyte, insulin-stimulated glucose transporter by G proteins AN - 41493945; 2277720 AU - Londos, C AU - Honnor, R C AU - Cushman, S W AU - Naghshineh, S AU - Simpson, IA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41493945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evidence+for+regulation+of+the+adipocyte%2C+insulin-stimulated+glucose+transporter+by+G+proteins&rft.au=Londos%2C+C%3BHonnor%2C+R+C%3BCushman%2C+S+W%3BNaghshineh%2C+S%3BSimpson%2C+IA&rft.aulast=Londos&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Xenopus transcription factor IIIA: Evidence for heterogeneity of Zn super(2+) binding affinities and specific labeling of Cys-287 AN - 41493105; 2273037 AU - Han, M AU - Cyran, F AU - Fisher, M AU - Kim, S AU - Ginsburg, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41493105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Xenopus+transcription+factor+IIIA%3A+Evidence+for+heterogeneity+of+Zn+super%282%2B%29+binding+affinities+and+specific+labeling+of+Cys-287&rft.au=Han%2C+M%3BCyran%2C+F%3BFisher%2C+M%3BKim%2C+S%3BGinsburg%2C+A&rft.aulast=Han&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preferential nuclear compartmentalization of endogenous MCF-related retroviral transcripts AN - 41492754; 2284050 AU - Gourley, M F AU - Krieg, A M AU - Steinberg, AD Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41492754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preferential+nuclear+compartmentalization+of+endogenous+MCF-related+retroviral+transcripts&rft.au=Gourley%2C+M+F%3BKrieg%2C+A+M%3BSteinberg%2C+AD&rft.aulast=Gourley&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human cerebral capillary endothelial cells: Induction of HLA-DR antign expression by IFN gamma AN - 41492156; 2275708 AU - McCarron, R M AU - Wang, L AU - Cowan, E AU - Spatz, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41492156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+cerebral+capillary+endothelial+cells%3A+Induction+of+HLA-DR+antign+expression+by+IFN+gamma&rft.au=McCarron%2C+R+M%3BWang%2C+L%3BCowan%2C+E%3BSpatz%2C+M&rft.aulast=McCarron&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Paper No. 952 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Murine thymocyte subsets with unique CD4/CD8 expression patterns: Identification of transitional double positive (CD4 super(+), CD8 super(+)) thymocytes AN - 41491746; 2270757 AU - Sharrow, SO AU - Roberts, J AU - Sheard, MA AU - Barden, LA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41491746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Murine+thymocyte+subsets+with+unique+CD4%2FCD8+expression+patterns%3A+Identification+of+transitional+double+positive+%28CD4+super%28%2B%29%2C+CD8+super%28%2B%29%29+thymocytes&rft.au=Sharrow%2C+SO%3BRoberts%2C+J%3BSheard%2C+MA%3BBarden%2C+LA&rft.aulast=Sharrow&rft.aufirst=SO&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HTLV-1 tax is able to transactivate the human lymphotoxin gene AN - 41491154; 2271204 AU - Tschachler, E AU - Boehnlein, E AU - Felzmann, S AU - Gallo, R C AU - Reitz, Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41491154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HTLV-1+tax+is+able+to+transactivate+the+human+lymphotoxin+gene&rft.au=Tschachler%2C+E%3BBoehnlein%2C+E%3BFelzmann%2C+S%3BGallo%2C+R+C%3BReitz%2C+Jr&rft.aulast=Tschachler&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inactivation of HIV-1 and HIV-2 proteases through oxidative modification AN - 41490523; 3429228 AU - Davis, DA AU - Newcomb, F M AU - Moskovitz, J AU - Wingfield, P T AU - Kaufmann, J AU - Stahl, S J AU - Fales, H M AU - Levine, R L AU - Yarchoan, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:Chemistry and Chemical Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41490523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inactivation+of+HIV-1+and+HIV-2+proteases+through+oxidative+modification&rft.au=Davis%2C+DA%3BNewcomb%2C+F+M%3BMoskovitz%2C+J%3BWingfield%2C+P+T%3BKaufmann%2C+J%3BStahl%2C+S+J%3BFales%2C+H+M%3BLevine%2C+R+L%3BYarchoan%2C+R&rft.aulast=Davis&rft.aufirst=DA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elsevier Science, Inc., Commercial Reprints Dept., 655 Avenue of the Americas, New York, NY 10010-5107, USA; 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Paper No. 204 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hormone-sensitive cyclic AMP phosphodiesterase in rat adipocytes: Regulation by adenosine AN - 41488892; 2287038 AU - Smith, C J AU - Vasta, V AU - Degerman, E AU - Belfrage, P AU - Manganiello, V C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41488892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hormone-sensitive+cyclic+AMP+phosphodiesterase+in+rat+adipocytes%3A+Regulation+by+adenosine&rft.au=Smith%2C+C+J%3BVasta%2C+V%3BDegerman%2C+E%3BBelfrage%2C+P%3BManganiello%2C+V+C&rft.aulast=Smith&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generation of T cell receptor( alpha beta ) super(+) double negative (CD4 super(-)8 super(-)) thymocytes AN - 41488177; 2270762 AU - Takahama, Y AU - Kosugi, A AU - Shearer, G M AU - Singer, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41488177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Generation+of+T+cell+receptor%28+alpha+beta+%29+super%28%2B%29+double+negative+%28CD4+super%28-%298+super%28-%29%29+thymocytes&rft.au=Takahama%2C+Y%3BKosugi%2C+A%3BShearer%2C+G+M%3BSinger%2C+A&rft.aulast=Takahama&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of high- and low-molecular weight forms of stimulatory G-protein in brain: Effects of chronic ethanol ingestion AN - 41487224; 2257045 AU - Whelan, J P AU - Hoffman, P L AU - Tabakoff, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41487224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distribution+of+high-+and+low-molecular+weight+forms+of+stimulatory+G-protein+in+brain%3A+Effects+of+chronic+ethanol+ingestion&rft.au=Whelan%2C+J+P%3BHoffman%2C+P+L%3BTabakoff%2C+B&rft.aulast=Whelan&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a putative human 23 kDa highly basic protein: Multiple mRNAs arise through utilization of alternative polyadenylation signals AN - 41487210; 2273950 AU - Price AU - Nightingale AU - Tsai, S-C AU - Tsuchiya, M AU - Bobak, DA AU - Moss, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41487210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+a+putative+human+23+kDa+highly+basic+protein%3A+Multiple+mRNAs+arise+through+utilization+of+alternative+polyadenylation+signals&rft.au=Price%3BNightingale%3BTsai%2C+S-C%3BTsuchiya%2C+M%3BBobak%2C+DA%3BMoss%2C+J&rft.aulast=Price&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ick signal transduction in human T lymphocytes AN - 41486819; 2280460 AU - Bolen, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41486819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ick+signal+transduction+in+human+T+lymphocytes&rft.au=Bolen%2C+J&rft.aulast=Bolen&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Internalized insulin stimulates protein synthesis in stage IV Xenopus laevis oocytes AN - 41486691; 2227086 AU - Miller, D S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41486691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Internalized+insulin+stimulates+protein+synthesis+in+stage+IV+Xenopus+laevis+oocytes&rft.au=Miller%2C+D+S&rft.aulast=Miller&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Paper No. 785 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abnormal B cell proliferation to high molecular weight B cell growth factor in common variable immunodeficiency AN - 41486586; 2269649 AU - Ambrus, JL Jr AU - Haneiwich, S AU - Chesky, L AU - McFarland, P AU - Engler, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41486586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Abnormal+B+cell+proliferation+to+high+molecular+weight+B+cell+growth+factor+in+common+variable+immunodeficiency&rft.au=Ambrus%2C+JL+Jr%3BHaneiwich%2C+S%3BChesky%2C+L%3BMcFarland%2C+P%3BEngler%2C+R&rft.aulast=Ambrus&rft.aufirst=JL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Paper No. 34 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequences of human immunoglobulin switch sites: Implications for recombination and transcription AN - 41486007; 2283125 AU - Mills, F AU - Brooker, J AU - Camerini-Otero, R D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41486007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sequences+of+human+immunoglobulin+switch+sites%3A+Implications+for+recombination+and+transcription&rft.au=Mills%2C+F%3BBrooker%2C+J%3BCamerini-Otero%2C+R+D&rft.aulast=Mills&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene structure of rabbit cytochrome P-450 isozyme 5 (aromatic amine N-hydroxylase) AN - 41483803; 2244398 AU - Duignan, D B AU - Gasser, R AU - Philpot, R M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41483803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Gene+structure+of+rabbit+cytochrome+P-450+isozyme+5+%28aromatic+amine+N-hydroxylase%29&rft.au=Duignan%2C+D+B%3BGasser%2C+R%3BPhilpot%2C+R+M&rft.aulast=Duignan&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Translation factors and T cell activation AN - 41483565; 2280146 AU - Boal, T R AU - Cohen, R B AU - Chiorini, JA AU - Safer, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41483565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Translation+factors+and+T+cell+activation&rft.au=Boal%2C+T+R%3BCohen%2C+R+B%3BChiorini%2C+JA%3BSafer%2C+B&rft.aulast=Boal&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oncogenic potential of overexpression of PDGF-A and -B chain genes in immortalized, non-tumorigenic, human mesothelial cells AN - 41483267; 2257434 AU - Van der Meeren, A AU - Gerwin, B I AU - Seddon, M AU - Betsholtz, C AU - Lechner, J F AU - Harris, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41483267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Oncogenic+potential+of+overexpression+of+PDGF-A+and+-B+chain+genes+in+immortalized%2C+non-tumorigenic%2C+human+mesothelial+cells&rft.au=Van+der+Meeren%2C+A%3BGerwin%2C+B+I%3BSeddon%2C+M%3BBetsholtz%2C+C%3BLechner%2C+J+F%3BHarris%2C+C+C&rft.aulast=Van+der+Meeren&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Paper No. 5062 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of chronic delta super(9)-tetrahydrocannabinol on free intracellular calcium and adenylate cyclase in mouse whole brain synaptosomes AN - 41482168; 2254617 AU - Bass, P P AU - Little, P J AU - Olson, K G AU - Welch, S P AU - Chan, P AU - Sendelbach, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41482168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+chronic+delta+super%289%29-tetrahydrocannabinol+on+free+intracellular+calcium+and+adenylate+cyclase+in+mouse+whole+brain+synaptosomes&rft.au=Bass%2C+P+P%3BLittle%2C+P+J%3BOlson%2C+K+G%3BWelch%2C+S+P%3BChan%2C+P%3BSendelbach%2C+L&rft.aulast=Bass&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T cell receptor: Receptor diversity and diverse function AN - 41481540; 2269516 AU - Klausner, R D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41481540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=T+cell+receptor%3A+Receptor+diversity+and+diverse+function&rft.au=Klausner%2C+R+D&rft.aulast=Klausner&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Methylation- and mutation-induced stimulation of in vitro AluK transcription AN - 41480532; 2258118 AU - Vorce, R AU - Sakamoto, K AU - Howard, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41480532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Methylation-+and+mutation-induced+stimulation+of+in+vitro+AluK+transcription&rft.au=Vorce%2C+R%3BSakamoto%2C+K%3BHoward%2C+B&rft.aulast=Vorce&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metal-catalyzed oxidation of a peptide and homopolymers of amino acids AN - 41478513; 2274397 AU - Poston, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41478513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Metal-catalyzed+oxidation+of+a+peptide+and+homopolymers+of+amino+acids&rft.au=Poston%2C+J+M&rft.aulast=Poston&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuropeptide Y in Brattleboro and salt-loaded rats AN - 41477363; 2244205 AU - Majane, E A AU - Yang, H-YT Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41477363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neuropeptide+Y+in+Brattleboro+and+salt-loaded+rats&rft.au=Majane%2C+E+A%3BYang%2C+H-YT&rft.aulast=Majane&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional brain metabolism in relation to cognitive decline AN - 41475914; 3413077 AU - Pietrini, P AU - Guazzelli, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41475914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regional+brain+metabolism+in+relation+to+cognitive+decline&rft.au=Pietrini%2C+P%3BGuazzelli%2C+M&rft.aulast=Pietrini&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Eslevier Science, P.O. Box 945, New York, NY 10159-0945, USA; phone: (212) 633-3730; fax: (212) 633-3680; email: usinfo@elsevier.com, Abstracts available. Price $145. Paper No. 79 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do antigen-pulsed monocytes and infected monocytes induce distinct responses in Leishmania -specific human T cells? AN - 41475864; 2281278 AU - Cooper, A M AU - Karp, CL AU - Melby, P C AU - Sacks, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41475864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Do+antigen-pulsed+monocytes+and+infected+monocytes+induce+distinct+responses+in+Leishmania+-specific+human+T+cells%3F&rft.au=Cooper%2C+A+M%3BKarp%2C+CL%3BMelby%2C+P+C%3BSacks%2C+D+L&rft.aulast=Cooper&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic action of abl and myc in retroviral induced intraperitoneal plasmacytomas in pristane-treated BALB/c mice AN - 41474904; 2291361 AU - Mischak, H AU - Weissinger, E AU - Largaespada, D AU - Risser, R AU - Mushinski, J F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41474904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Synergistic+action+of+abl+and+myc+in+retroviral+induced+intraperitoneal+plasmacytomas+in+pristane-treated+BALB%2Fc+mice&rft.au=Mischak%2C+H%3BWeissinger%2C+E%3BLargaespada%2C+D%3BRisser%2C+R%3BMushinski%2C+J+F&rft.aulast=Mischak&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Foundation for Advanced Cancer Studies N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Importance of gay, lesbian, and bisexual research AN - 41473725; 3402501 AU - Parron, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41473725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Importance+of+gay%2C+lesbian%2C+and+bisexual+research&rft.au=Parron%2C+D+L&rft.aulast=Parron&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Psychological Association, 750 First St., N.E., Washington, DC 20002-4242, USA; phone: (202) 336-5500; email: convention.office@apa.org; URL: http://www.apa.org, Contact APA for availability. 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N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental toxicity of brominated dibenzodioxin and furans in mice AN - 41473542; 2190650 AU - Harris, M W AU - Allen, J D AU - Haskins, E A AU - Morrissey, R M AU - Birnbaum, L S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41473542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Developmental+toxicity+of+brominated+dibenzodioxin+and+furans+in+mice&rft.au=Harris%2C+M+W%3BAllen%2C+J+D%3BHaskins%2C+E+A%3BMorrissey%2C+R+M%3BBirnbaum%2C+L+S&rft.aulast=Harris&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. 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Fax: 202-371-1090., Poster Paper No. 1251 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of estrogens in liver tumor promotion by TCDD in rats AN - 41473502; 2190620 AU - Lucier, G AU - Goldsworthy, T AU - Foley, J AU - Goldstein, J AU - Clark, G AU - Maronpot, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41473502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+estrogens+in+liver+tumor+promotion+by+TCDD+in+rats&rft.au=Lucier%2C+G%3BGoldsworthy%2C+T%3BFoley%2C+J%3BGoldstein%2C+J%3BClark%2C+G%3BMaronpot%2C+R&rft.aulast=Lucier&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. 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Fax: 202-371-1090., Poster Paper No. 1244 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New fluorogenic substrates for detection of beta -galactosidase in vitro and in vivo AN - 41473160; 2285043 AU - Miller, SPF AU - Kaneski, C AU - French, SA AU - Harbour, M AU - Brescia, M AU - Brady, RO Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41473160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Abnormal+B+cell+proliferation+to+high+molecular+weight+B+cell+growth+factor+in+common+variable+immunodeficiency&rft.au=Ambrus%2C+JL+Jr%3BHaneiwich%2C+S%3BChesky%2C+L%3BMcFarland%2C+P%3BEngler%2C+R&rft.aulast=Ambrus&rft.aufirst=JL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) results in achondroplasia mice by activation of STATs and ink4 cell cycle inhibitors AN - 41472522; 3418836 AU - Deng, C X AU - Li, C AU - Chen, L AU - Iwata, T AU - Kitagawa, M AU - Fu, X Y Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41472522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lys644Glu+substitution+in+fibroblast+growth+factor+receptor+3+%28FGFR3%29+results+in+achondroplasia+mice+by+activation+of+STATs+and+ink4+cell+cycle+inhibitors&rft.au=Deng%2C+C+X%3BLi%2C+C%3BChen%2C+L%3BIwata%2C+T%3BKitagawa%2C+M%3BFu%2C+X+Y&rft.aulast=Deng&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Human Genetics, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 571-1825; email: subscriptions@journals.uchicago.edu, Abstracts available. 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Poster Paper No. 2068 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of naltrexone on ingestive behavior AN - 41471493; 2227013 AU - Hetherington, M M AU - Rolls, B J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41471493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+naltrexone+on+ingestive+behavior&rft.au=Hetherington%2C+M+M%3BRolls%2C+B+J&rft.aulast=Hetherington&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the human nuclear receptor co-repressor (N-CoR) as a mediator of transcriptional repression by the t(8; 21)acute myeloid leukemia fusion protein AN - 41469480; 3416971 AU - Wang, J AU - Stacey, M W AU - Byrd, R L AU - Liu, J M AU - Kearns, W G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41469480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+the+human+nuclear+receptor+co-repressor+%28N-CoR%29+as+a+mediator+of+transcriptional+repression+by+the+t%288%3B+21%29acute+myeloid+leukemia+fusion+protein&rft.au=Wang%2C+J%3BStacey%2C+M+W%3BByrd%2C+R+L%3BLiu%2C+J+M%3BKearns%2C+W+G&rft.aulast=Wang&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Human Genetics, 9650 Rockville Pike, Bethesda, MD 20814, USA; phone: (301) 571-1825; email: subscriptions@journals.uchicago.edu, Abstracts available. 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Paper No. 202 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maternal genetic contributions to CSF monoamines in the rhesus macaque AN - 41465543; 2273944 AU - Higley, J D AU - Goldman, D AU - Champoux, M AU - Hasert, M F AU - Suomi, S J AU - Linnoila, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41465543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Maternal+genetic+contributions+to+CSF+monoamines+in+the+rhesus+macaque&rft.au=Higley%2C+J+D%3BGoldman%2C+D%3BChampoux%2C+M%3BHasert%2C+M+F%3BSuomi%2C+S+J%3BLinnoila%2C+M&rft.aulast=Higley&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Journals Fulfillment Department, Elsevier Science Publishing Co., Inc., 655 Avenue of the Americas, New York, NY 10010, USA, Biological Psychiatry, Volume 27, Number 9A, May 1990, ISSN: 0006-3223 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Free radical-mediated alteration of the prosthetic group of hemoglobin AN - 41464826; 2234381 AU - Kindt, J T AU - Osawa, Y AU - Martin, B M AU - Chen, L AU - Cotter, R J AU - Pohl, L R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41464826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Free+radical-mediated+alteration+of+the+prosthetic+group+of+hemoglobin&rft.au=Kindt%2C+J+T%3BOsawa%2C+Y%3BMartin%2C+B+M%3BChen%2C+L%3BCotter%2C+R+J%3BPohl%2C+L+R&rft.aulast=Kindt&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of hepatic lipase in lipoprotein metabolism and atherosclerosis AN - 41462329; 3388801 AU - Santamarina-Fojo, S AU - Amar, M AU - Haudenchild, C AU - Dugi, K AU - Brewer, HB Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41462329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+hepatic+lipase+in+lipoprotein+metabolism+and+atherosclerosis&rft.au=Santamarina-Fojo%2C+S%3BAmar%2C+M%3BHaudenchild%2C+C%3BDugi%2C+K%3BBrewer%2C+HB+Jr&rft.aulast=Santamarina-Fojo&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: DALM '98, 6565 Fannin Street, MS A-601, Houston, TX 77030, USA; phone: (713) 797-0401; fax: (713) 796-8853; email: ajackson@bcm.tmc.edu, Abstracts available. 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N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phosphorylation of a recombinant protein corresponding to the C-terminal half of the CCAAT-enhancer binding protein by protein kinase C AN - 41462014; 2272996 AU - Mahoney, C W AU - Shuman, J AU - McKnight, S L AU - Chen, H-C AU - Huang, K-P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41462014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Phosphorylation+of+a+recombinant+protein+corresponding+to+the+C-terminal+half+of+the+CCAAT-enhancer+binding+protein+by+protein+kinase+C&rft.au=Mahoney%2C+C+W%3BShuman%2C+J%3BMcKnight%2C+S+L%3BChen%2C+H-C%3BHuang%2C+K-P&rft.aulast=Mahoney&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of phospholipase C isozymes by protein kinases AN - 41458019; 2275508 AU - Rhee, S G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41458019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+phospholipase+C+isozymes+by+protein+kinases&rft.au=Rhee%2C+S+G&rft.aulast=Rhee&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Paper No. 924 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Persistence of hydronephrosis in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) AN - 41456108; 2190643 AU - Couture, LA AU - Harris, M W AU - Clark, A M AU - Birnbaum, L S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41456108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Persistence+of+hydronephrosis+in+mice+following+in+utero+and%2For+lactational+exposure+to+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+%28TCDD%29&rft.au=Couture%2C+LA%3BHarris%2C+M+W%3BClark%2C+A+M%3BBirnbaum%2C+L+S&rft.aulast=Couture&rft.aufirst=LA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1101 14th St., NW, Ste. 1100, Washington, DC 20005, USA. 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Fax: 202-371-1090., Poster Paper No. 1250 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of acidic fibroblast growth factor in the developing rat embryo AN - 41455692; 2229635 AU - Fu, Y-M AU - Yu, Z-X AU - Spirito, P AU - Speir, E AU - Biro, S AU - Lei, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41455692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distribution+of+acidic+fibroblast+growth+factor+in+the+developing+rat+embryo&rft.au=Fu%2C+Y-M%3BYu%2C+Z-X%3BSpirito%2C+P%3BSpeir%2C+E%3BBiro%2C+S%3BLei%2C+J&rft.aulast=Fu&rft.aufirst=Y-M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biosynthesis and identification of seleno-tRNAs AN - 41454707; 2289968 AU - Veres, Z AU - Politino, M AU - Tsai, L AU - Stadtman, T C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41454707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biosynthesis+and+identification+of+seleno-tRNAs&rft.au=Veres%2C+Z%3BPolitino%2C+M%3BTsai%2C+L%3BStadtman%2C+T+C&rft.aulast=Veres&rft.aufirst=Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intrathymic stem cells follow an IL-2/IL-2R path AN - 41454602; 2281211 AU - Kruisbeek, A M AU - Zuniga-Pfluecker, J C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41454602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intrathymic+stem+cells+follow+an+IL-2%2FIL-2R+path&rft.au=Kruisbeek%2C+A+M%3BZuniga-Pfluecker%2C+J+C&rft.aulast=Kruisbeek&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetic analysis of cell Ca super(2+) flux AN - 41453669; 2258897 AU - Mazorow, D L AU - Millar, D B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41453669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Kinetic+analysis+of+cell+Ca+super%282%2B%29+flux&rft.au=Mazorow%2C+D+L%3BMillar%2C+D+B&rft.aulast=Mazorow&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro transcription assay for the study of structure-function relations of HIV-TAT protein AN - 41453190; 2288537 AU - Yuan, J-G AU - Shieh, T-C AU - Schechter, AN AU - Noguchi, C T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41453190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vitro+transcription+assay+for+the+study+of+structure-function+relations+of+HIV-TAT+protein&rft.au=Yuan%2C+J-G%3BShieh%2C+T-C%3BSchechter%2C+AN%3BNoguchi%2C+C+T&rft.aulast=Yuan&rft.aufirst=J-G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolic activation of myoglobin after treatment with BrCCl sub(3) or hydrogen peroxide AN - 41452304; 2289721 AU - Osawa, Y AU - Korzekwa, K AU - Pohl, L R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41452304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Metabolic+activation+of+myoglobin+after+treatment+with+BrCCl+sub%283%29+or+hydrogen+peroxide&rft.au=Osawa%2C+Y%3BKorzekwa%2C+K%3BPohl%2C+L+R&rft.aulast=Osawa&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular cytotoxicity to HIV AN - 41451849; 2280559 AU - Koenig, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41451849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cellular+cytotoxicity+to+HIV&rft.au=Koenig%2C+S&rft.aulast=Koenig&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcium ion fluxes mediate sustained release of endogenous striatal dopamine by toxic doses of MPP super(+) in vivo AN - 41441757; 2233130 AU - Lang, K AU - Huang, S-J AU - Miyake, H AU - Chiueh, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41441757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Calcium+ion+fluxes+mediate+sustained+release+of+endogenous+striatal+dopamine+by+toxic+doses+of+MPP+super%28%2B%29+in+vivo&rft.au=Lang%2C+K%3BHuang%2C+S-J%3BMiyake%2C+H%3BChiueh%2C+C+C&rft.aulast=Lang&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - N-terminal V2 vasopressin receptor fragments inhibit wild type receptor function via heterodimer formation AN - 41439702; 3381263 AU - Zhu, X AU - Wess, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41439702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=N-terminal+V2+vasopressin+receptor+fragments+inhibit+wild+type+receptor+function+via+heterodimer+formation&rft.au=Zhu%2C+X%3BWess%2C+J&rft.aulast=Zhu&rft.aufirst=X&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; 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Poster Paper No. T 853 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bivalent disulfide-stabilized Fv with improved antigen binding to erbB2 AN - 41439199; 3381092 AU - Bera, T K AU - Onda, M AU - Brinkmann, U AU - Pastan, I H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41439199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Bivalent+disulfide-stabilized+Fv+with+improved+antigen+binding+to+erbB2&rft.au=Bera%2C+T+K%3BOnda%2C+M%3BBrinkmann%2C+U%3BPastan%2C+I+H&rft.aulast=Bera&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. T 682 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transmembrane topology of glucose-6-phosphatase AN - 41439006; 3381204 AU - Pan, C-J AU - Aannabi, B AU - Chou, J Y Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41439006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transmembrane+topology+of+glucose-6-phosphatase&rft.au=Pan%2C+C-J%3BAannabi%2C+B%3BChou%2C+J+Y&rft.aulast=Pan&rft.aufirst=C-J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. W 794 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular chaperone function of ClpA in plasmid P1 RepA activation AN - 41438947; 3381049 AU - Pak, M AU - Singh, S K AU - Maurizi, M AU - Wickner, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41438947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+chaperone+function+of+ClpA+in+plasmid+P1+RepA+activation&rft.au=Pak%2C+M%3BSingh%2C+S+K%3BMaurizi%2C+M%3BWickner%2C+S&rft.aulast=Pak&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 639 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Low concentrations of the Na super(+),K super(+)-ATPase ligand ouabain activate intracellular signaling enzymes AN - 41437946; 3381247 AU - Foley, T D AU - Linnoila, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41437946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Low+concentrations+of+the+Na+super%28%2B%29%2CK+super%28%2B%29-ATPase+ligand+ouabain+activate+intracellular+signaling+enzymes&rft.au=Foley%2C+T+D%3BLinnoila%2C+M&rft.aulast=Foley&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 837 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Catalytic properties of selenophosphate synthetase enzymes AN - 41435151; 3381165 AU - Lacourciere, G M AU - Stadtman, T C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41435151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Catalytic+properties+of+selenophosphate+synthetase+enzymes&rft.au=Lacourciere%2C+G+M%3BStadtman%2C+T+C&rft.aulast=Lacourciere&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. W 755 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PKC- and IL-3 regulate actin cytoskeleton rearrangements associated with the effects on cell cycle by two distinct pathways: PKC-d dominates over IL-3 signal AN - 41434390; 3380953 AU - Romanova, L AU - Alexandrov, I AU - Nguyen, M AU - Nordan, R AU - Trepel, J AU - Mushinski, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41434390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=PKC-+and+IL-3+regulate+actin+cytoskeleton+rearrangements+associated+with+the+effects+on+cell+cycle+by+two+distinct+pathways%3A+PKC-d+dominates+over+IL-3+signal&rft.au=Romanova%2C+L%3BAlexandrov%2C+I%3BNguyen%2C+M%3BNordan%2C+R%3BTrepel%2C+J%3BMushinski%2C+F&rft.aulast=Romanova&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 543 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppression of nitric oxide and cytokine-induced apoptotic cell death by IGF-1 in insulin receptor knockout hepatocytes AN - 41433518; 3381405 AU - Makar, T K AU - Accili, D AU - Milstien, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41433518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Suppression+of+nitric+oxide+and+cytokine-induced+apoptotic+cell+death+by+IGF-1+in+insulin+receptor+knockout+hepatocytes&rft.au=Makar%2C+T+K%3BAccili%2C+D%3BMilstien%2C+S&rft.aulast=Makar&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. W 995 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of transgenic mice carrying the human ALDH2 super(2) (oriental variant) allele AN - 41433361; 3380681 AU - Jeng, J AU - Kallarakal, A AU - Eriksson, P AU - Goldman, D AU - Wang, T AU - Weiner, H AU - Song, B J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41433361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+transgenic+mice+carrying+the+human+ALDH2+super%282%29+%28oriental+variant%29+allele&rft.au=Jeng%2C+J%3BKallarakal%2C+A%3BEriksson%2C+P%3BGoldman%2C+D%3BWang%2C+T%3BWeiner%2C+H%3BSong%2C+B+J&rft.aulast=Jeng&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 270 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antigenic variants of Candida albicans isolated in AIDS AN - 41432662; 2172321 AU - Whelan, W L AU - Delga, J M AU - Wadsworth, E AU - Kwon-Chung, K J AU - Calderone, R AU - Lipke, P N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41432662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Antigenic+variants+of+Candida+albicans+isolated+in+AIDS&rft.au=Whelan%2C+W+L%3BDelga%2C+J+M%3BWadsworth%2C+E%3BKwon-Chung%2C+K+J%3BCalderone%2C+R%3BLipke%2C+P+N&rft.aulast=Whelan&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Hugo Vanden Bossche, Janssen Research Foundation, Life Sciences, Department Comparative Biochemistry, B-2340 Beerse, Belgium., Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Residues required for dRP lyase activity in the N-terminal 8 kDa domain of DNA polymerase b AN - 41431937; 3380655 AU - Prasad, R AU - Beard, WA AU - Chyan, J Y AU - Maciejewski, M W AU - Mullen, G P AU - Wilson, SH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41431937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Residues+required+for+dRP+lyase+activity+in+the+N-terminal+8+kDa+domain+of+DNA+polymerase+b&rft.au=Prasad%2C+R%3BBeard%2C+WA%3BChyan%2C+J+Y%3BMaciejewski%2C+M+W%3BMullen%2C+G+P%3BWilson%2C+SH&rft.aulast=Prasad&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. T 244 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathologic and molecular characterization of transgenic mouse model for neurofibromatosis AN - 41430743; 2165037 AU - Green, JE AU - Hinrichs, SH AU - Begley, G C AU - Wagner, D K AU - Waldmann, T A AU - Jay, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41430743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pathologic+and+molecular+characterization+of+transgenic+mouse+model+for+neurofibromatosis&rft.au=Green%2C+JE%3BHinrichs%2C+SH%3BBegley%2C+G+C%3BWagner%2C+D+K%3BWaldmann%2C+T+A%3BJay%2C+G&rft.aulast=Green&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASHG, 9650 Rockville Pike, Bethesda, MD 20814, Paper No. 0745 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of phospholipase C-g by the concerted action of AHNAK-related protein and arachidonic acid in the absence of tyrosine phosphorylation AN - 41430367; 3380842 AU - Sekiya, F AU - Bae, Y S AU - Rhee, S G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41430367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Activation+of+phospholipase+C-g+by+the+concerted+action+of+AHNAK-related+protein+and+arachidonic+acid+in+the+absence+of+tyrosine+phosphorylation&rft.au=Sekiya%2C+F%3BBae%2C+Y+S%3BRhee%2C+S+G&rft.aulast=Sekiya&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 432 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in B lymphocyte Fc gamma R II expression and ligand binding capacity induced by various activators AN - 41429723; 2120271 AU - Laszlo, G AU - Dickler, H B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41429723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Changes+in+B+lymphocyte+Fc+gamma+R+II+expression+and+ligand+binding+capacity+induced+by+various+activators&rft.au=Laszlo%2C+G%3BDickler%2C+H+B&rft.aulast=Laszlo&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic organization of rabbit TCR beta chain genes AN - 41427745; 2099454 AU - Harindranath, N AU - Lamoyi, E AU - Mage, R G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41427745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genomic+organization+of+rabbit+TCR+beta+chain+genes&rft.au=Harindranath%2C+N%3BLamoyi%2C+E%3BMage%2C+R+G&rft.aulast=Harindranath&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Requirement for accessory cells in generation of porcine alloresponses AN - 41427149; 2119519 AU - Sundt, T M AU - Kortz, E O AU - Lunney, J K AU - Sachs, D H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41427149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Requirement+for+accessory+cells+in+generation+of+porcine+alloresponses&rft.au=Sundt%2C+T+M%3BKortz%2C+E+O%3BLunney%2C+J+K%3BSachs%2C+D+H&rft.aulast=Sundt&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T cell priming in vivo can be mediated by an IL-2-independent cyclosporine A-resistant pathway AN - 41426564; 2100455 AU - Pereira, GMB AU - Miller, J F AU - Yokoyama, WM AU - Shevach, E M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41426564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=T+cell+priming+in+vivo+can+be+mediated+by+an+IL-2-independent+cyclosporine+A-resistant+pathway&rft.au=Pereira%2C+GMB%3BMiller%2C+J+F%3BYokoyama%2C+WM%3BShevach%2C+E+M&rft.aulast=Pereira&rft.aufirst=GMB&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human J chain gene promoter contains multiple functional segments including an NF Kappa B binding site AN - 41425448; 2119463 AU - Max, EE AU - Flanagan, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41425448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+J+chain+gene+promoter+contains+multiple+functional+segments+including+an+NF+Kappa+B+binding+site&rft.au=Max%2C+EE%3BFlanagan%2C+J+R&rft.aulast=Max&rft.aufirst=EE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of structural elements that determine the G protein coupling selectivity of the V2 vasopressin receptor AN - 41424944; 3381265 AU - Erlenbach, I AU - Wess, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41424944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+structural+elements+that+determine+the+G+protein+coupling+selectivity+of+the+V2+vasopressin+receptor&rft.au=Erlenbach%2C+I%3BWess%2C+J&rft.aulast=Erlenbach&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 855 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Urea denaturation of isolated E coli nucleoids AN - 41424227; 3381170 AU - Zimmerman, S B AU - Murphy, L D AU - Rosner, J L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41424227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Urea+denaturation+of+isolated+E+coli+nucleoids&rft.au=Zimmerman%2C+S+B%3BMurphy%2C+L+D%3BRosner%2C+J+L&rft.aulast=Zimmerman&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. T 760 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell surface T cell receptor induction by CD4, CD8 thymocytes cultured with IL-1 + IL-2 AN - 41422903; 2099412 AU - Takashi, T AU - Steinberg, AD AU - Gause, W C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41422903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cell+surface+T+cell+receptor+induction+by+CD4%2C+CD8+thymocytes+cultured+with+IL-1+%2B+IL-2&rft.au=Takashi%2C+T%3BSteinberg%2C+AD%3BGause%2C+W+C&rft.aulast=Takashi&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T cell receptor-triggered changes in membrane-cytoskeleton associations in cloned cytolytic T lymphocytes AN - 41422523; 2109032 AU - Taffs, R E AU - Sitkovsky, M V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41422523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=T+cell+receptor-triggered+changes+in+membrane-cytoskeleton+associations+in+cloned+cytolytic+T+lymphocytes&rft.au=Taffs%2C+R+E%3BSitkovsky%2C+M+V&rft.aulast=Taffs&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T cell clones produce IL-4 but fail to proliferate following activation by fixed antigen-presenting cells AN - 41422302; 2099973 AU - Aiello, F B AU - Longo, D L AU - Young, HA AU - Baker, S L AU - Durum, S K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41422302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=T+cell+clones+produce+IL-4+but+fail+to+proliferate+following+activation+by+fixed+antigen-presenting+cells&rft.au=Aiello%2C+F+B%3BLongo%2C+D+L%3BYoung%2C+HA%3BBaker%2C+S+L%3BDurum%2C+S+K&rft.aulast=Aiello&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative xenobiotic metabolism between TG. AC and p53-deficient mice and their respective wild types AN - 41421544; 3364412 AU - Sanders, J M AU - Burka, L T AU - Fossett, JE AU - Matthews, H B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41421544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparative+xenobiotic+metabolism+between+TG.+AC+and+p53-deficient+mice+and+their+respective+wild+types&rft.au=Sanders%2C+J+M%3BBurka%2C+L+T%3BFossett%2C+JE%3BMatthews%2C+H+B&rft.aulast=Sanders&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1636 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transfection of CHO cells in culture with increasing mouse selenocysteine tRNA gene copy numbers AN - 41421313; 3380873 AU - Moustafa, ME AU - Lee, B J AU - Kandeel, K M AU - El-Saadani, MA AU - Hatfield, D L AU - Diamond, A M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41421313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transfection+of+CHO+cells+in+culture+with+increasing+mouse+selenocysteine+tRNA+gene+copy+numbers&rft.au=Moustafa%2C+ME%3BLee%2C+B+J%3BKandeel%2C+K+M%3BEl-Saadani%2C+MA%3BHatfield%2C+D+L%3BDiamond%2C+A+M&rft.aulast=Moustafa&rft.aufirst=ME&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. T 463 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a common T cell binding region on the H-2K super(b) class I molecule AN - 41419589; 2109342 AU - Munitz, T AU - Schneck, J AU - Coligan, JE AU - Maloy, W L AU - Margulies, D H AU - Singer, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41419589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+a+common+T+cell+binding+region+on+the+H-2K+super%28b%29+class+I+molecule&rft.au=Munitz%2C+T%3BSchneck%2C+J%3BColigan%2C+JE%3BMaloy%2C+W+L%3BMargulies%2C+D+H%3BSinger%2C+A&rft.aulast=Munitz&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning of a novel homeobox gene residing on the X-chromosome of D. melanogaster AN - 41419567; 2099493 AU - Nakayama, K AU - Nakayama, N AU - Kim, Y AU - Webber, K AU - Lad, R AU - Ling, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41419567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+of+a+novel+homeobox+gene+residing+on+the+X-chromosome+of+D.+melanogaster&rft.au=Nakayama%2C+K%3BNakayama%2C+N%3BKim%2C+Y%3BWebber%2C+K%3BLad%2C+R%3BLing%2C+A&rft.aulast=Nakayama&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Genetics Society of America, Administrative Office, 9650 Rockville Pike, Bethesda, MD 20814 (USA)., Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chimeric MHC class I/membrane IgM molecule fails to signal in WEHI-231 cells AN - 41418501; 2113835 AU - Tsang, W K AU - McCluskey, J AU - Ishida, YA AU - Highet, P F AU - Inman, J K AU - Chused, T M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41418501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chimeric+MHC+class+I%2Fmembrane+IgM+molecule+fails+to+signal+in+WEHI-231+cells&rft.au=Tsang%2C+W+K%3BMcCluskey%2C+J%3BIshida%2C+YA%3BHighet%2C+P+F%3BInman%2C+J+K%3BChused%2C+T+M&rft.aulast=Tsang&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IGFBP-3 mediates b-induced growth inhibition in mink lung epithelial cell AN - 41418358; 3380603 AU - Wu, H-B AU - Tsai, W-C AU - Rechler, M M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41418358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IGFBP-3+mediates+b-induced+growth+inhibition+in+mink+lung+epithelial+cell&rft.au=Wu%2C+H-B%3BTsai%2C+W-C%3BRechler%2C+M+M&rft.aulast=Wu&rft.aufirst=H-B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 192 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prostaglandins are involved in stimulation of c-myc expression caused by EGF AN - 41416897; 2125972 AU - Handler, JA AU - Eling, TE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41416897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prostaglandins+are+involved+in+stimulation+of+c-myc+expression+caused+by+EGF&rft.au=Handler%2C+JA%3BEling%2C+TE&rft.aulast=Handler&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of mercury between maternal, fetal, and neonatal tissues following gestational exposure to elemental mercury vapor in Long-Evans rats AN - 41416503; 3362911 AU - Chanda, S M AU - Barone, S Jr AU - Price, H C AU - O'Connor, R W AU - Beliles, R P AU - Morgan, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41416503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distribution+of+mercury+between+maternal%2C+fetal%2C+and+neonatal+tissues+following+gestational+exposure+to+elemental+mercury+vapor+in+Long-Evans+rats&rft.au=Chanda%2C+S+M%3BBarone%2C+S+Jr%3BPrice%2C+H+C%3BO%27Connor%2C+R+W%3BBeliles%2C+R+P%3BMorgan%2C+D+L&rft.aulast=Chanda&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 135 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human chromogranin A gene: Chromosome assignment and RFLP analysis AN - 41416105; 2097966 AU - Modi, W S AU - Levine, MA AU - Seuanez, H N AU - Dean, M AU - O'Brien, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41416105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+chromogranin+A+gene%3A+Chromosome+assignment+and+RFLP+analysis&rft.au=Modi%2C+W+S%3BLevine%2C+MA%3BSeuanez%2C+H+N%3BDean%2C+M%3BO%27Brien%2C+S+J&rft.aulast=Modi&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for the Advancement of Science, 1333 H Street, NW, Washington, DC 20005 (USA)., Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction by recombinant lymphokines of viral expression from promonocytic and lymphocytic cell clones chronically infected with the human immunodeficiency virus type 1 AN - 41412929; 2126908 AU - Justement, J S AU - Poli, G AU - Kehrl, J AU - Kinter, A AU - Clouse, K AU - Folks, T M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41412929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+by+recombinant+lymphokines+of+viral+expression+from+promonocytic+and+lymphocytic+cell+clones+chronically+infected+with+the+human+immunodeficiency+virus+type+1&rft.au=Justement%2C+J+S%3BPoli%2C+G%3BKehrl%2C+J%3BKinter%2C+A%3BClouse%2C+K%3BFolks%2C+T+M&rft.aulast=Justement&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid generation of high titer retrovirus stocks using vectors without a selectable marker AN - 41412542; 2111150 AU - Muenchau, D AU - Anderson, W F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41412542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rapid+generation+of+high+titer+retrovirus+stocks+using+vectors+without+a+selectable+marker&rft.au=Muenchau%2C+D%3BAnderson%2C+W+F&rft.aulast=Muenchau&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of liver-associated large granular lymphocytes generated from thymic precursors AN - 41411961; 2095431 AU - Mathieson, B J AU - Gregorio, T AU - Mason, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41411961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+liver-associated+large+granular+lymphocytes+generated+from+thymic+precursors&rft.au=Mathieson%2C+B+J%3BGregorio%2C+T%3BMason%2C+L&rft.aulast=Mathieson&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of automated, preparative electrophoresis to facilitate subcloning of fragments for sequence analysis AN - 41411428; 2097116 AU - McCombie, W R AU - Iovannisci, D AU - Efcavitch, J W AU - Venter, J C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41411428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+automated%2C+preparative+electrophoresis+to+facilitate+subcloning+of+fragments+for+sequence+analysis&rft.au=McCombie%2C+W+R%3BIovannisci%2C+D%3BEfcavitch%2C+J+W%3BVenter%2C+J+C&rft.aulast=McCombie&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Genome Sequencing Conference, P.O. Box 541, Rockville, MD 20851 (USA). Fax: (301) 480-8588., Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclosporin A-induced defect in T cell development AN - 41409942; 2095478 AU - Kosugi, A AU - Shearer, G M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41409942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cyclosporin+A-induced+defect+in+T+cell+development&rft.au=Kosugi%2C+A%3BShearer%2C+G+M&rft.aulast=Kosugi&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a mouse model for cutaneous leishmaniasis due to Leishmania tropica AN - 41409188; 3361221 AU - Lira, R C AU - Mendez, S AU - Carrera, L AU - Jaffe, CL AU - Sacks, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41409188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Development+of+a+mouse+model+for+cutaneous+leishmaniasis+due+to+Leishmania+tropica&rft.au=Lira%2C+R+C%3BMendez%2C+S%3BCarrera%2C+L%3BJaffe%2C+CL%3BSacks%2C+D+L&rft.aulast=Lira&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASTMH, 60 Revere Drive, Suite 500, Northbrook, IL 60062, USA, Abstracts available. Price $10. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Colchicine lesions of ventral, but not dorsal, hippocampal dentate granule cells attenuate wet dog shakes elicited by direct hippocampal stimulation AN - 41409016; 2091295 AU - Barnes, MI AU - Mitchell, CL Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41409016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Colchicine+lesions+of+ventral%2C+but+not+dorsal%2C+hippocampal+dentate+granule+cells+attenuate+wet+dog+shakes+elicited+by+direct+hippocampal+stimulation&rft.au=Barnes%2C+MI%3BMitchell%2C+CL&rft.aulast=Barnes&rft.aufirst=MI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of selected tricyclic antidepressants on B lymphocyte function in B6C3F1 mice AN - 41408387; 2104320 AU - Germolec AU - Comment, CE AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41408387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+selected+tricyclic+antidepressants+on+B+lymphocyte+function+in+B6C3F1+mice&rft.au=Germolec%3BComment%2C+CE%3BLuster%2C+MI&rft.aulast=Germolec&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - V5 domain as the critical determinant of the isozyme-specific effects of protein kinase C-d and -e AN - 41407430; 3380999 AU - Wang, Q J AU - Mushinski, J F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41407430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=V5+domain+as+the+critical+determinant+of+the+isozyme-specific+effects+of+protein+kinase+C-d+and+-e&rft.au=Wang%2C+Q+J%3BMushinski%2C+J+F&rft.aulast=Wang&rft.aufirst=Q&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. T 589 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative metabolism and disposition of 1,2,3-trichloropropane (TCP) in rats and mice AN - 41405891; 2076357 AU - Mahmood, NA AU - Burka, L T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41405891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparative+metabolism+and+disposition+of+1%2C2%2C3-trichloropropane+%28TCP%29+in+rats+and+mice&rft.au=Mahmood%2C+NA%3BBurka%2C+L+T&rft.aulast=Mahmood&rft.aufirst=NA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1133 Fifteenth Street, NW, Suite 1000, Washington, DC 20005 (USA), Price: $ 20.00 + $ 3.00 for postage and handling Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-a AN - 41405784; 3381305 AU - Kang, S W AU - Chae, H Z AU - Seo AU - Kim, K AU - Baines, I C AU - Rhee, S G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41405784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mammalian+peroxiredoxin+isoforms+can+reduce+hydrogen+peroxide+generated+in+response+to+growth+factors+and+tumor+necrosis+factor-a&rft.au=Kang%2C+S+W%3BChae%2C+H+Z%3BSeo%3BKim%2C+K%3BBaines%2C+I+C%3BRhee%2C+S+G&rft.aulast=Kang&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. T 895 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Nef increases signal of T cell co-stimulatory pathway AN - 41405569; 3381243 AU - Schrager, JA AU - Marsh, J W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41405569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HIV-1+Nef+increases+signal+of+T+cell+co-stimulatory+pathway&rft.au=Schrager%2C+JA%3BMarsh%2C+J+W&rft.aulast=Schrager&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. W 833 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alp: An activity that increases proteolysis in E. coli AN - 41404913; 2067196 AU - Trempy, JE AU - Gottesman, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41404913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Alp%3A+An+activity+that+increases+proteolysis+in+E.+coli&rft.au=Trempy%2C+JE%3BGottesman%2C+S&rft.aulast=Trempy&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hematopoietic growth factors stimulate tyrosine phosphorylation of substrates also common to v-src family oncogenes AN - 41404160; 2106492 AU - Farrar, W L AU - Pierce, J AU - Ferris, D K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41404160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hematopoietic+growth+factors+stimulate+tyrosine+phosphorylation+of+substrates+also+common+to+v-src+family+oncogenes&rft.au=Farrar%2C+W+L%3BPierce%2C+J%3BFerris%2C+D+K&rft.aulast=Farrar&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Efficacy of Zn finger active compounds in Giardia lamblia AN - 41403839; 3361567 AU - Nash, T AU - Conrad, J T AU - Rice, W G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41403839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Efficacy+of+Zn+finger+active+compounds+in+Giardia+lamblia&rft.au=Nash%2C+T%3BConrad%2C+J+T%3BRice%2C+W+G&rft.aulast=Nash&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASTMH, 60 Revere Drive, Suite 500, Northbrook, IL 60062, USA, Abstracts available. 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N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adenosine selectively inhibits histamine receptor mediated phosphoinositide turnover in neurohybrid NCB-20 cells AN - 41402763; 2090805 AU - Chuang, D-M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41402763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Adenosine+selectively+inhibits+histamine+receptor+mediated+phosphoinositide+turnover+in+neurohybrid+NCB-20+cells&rft.au=Chuang%2C+D-M&rft.aulast=Chuang&rft.aufirst=D-M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). 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Fax: 01-240 7735 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell-laminin interactions in small cell lung carcinoma cell lines AN - 41400209; 2066382 AU - Fridman, R AU - Kanemoto, T AU - Burrous, BA AU - Reich, R AU - Segui-Real, B AU - Martin, G R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41400209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cell-laminin+interactions+in+small+cell+lung+carcinoma+cell+lines&rft.au=Fridman%2C+R%3BKanemoto%2C+T%3BBurrous%2C+BA%3BReich%2C+R%3BSegui-Real%2C+B%3BMartin%2C+G+R&rft.aulast=Fridman&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromatin structure and developmental regulation of chromosomal protein HMG-17 gene in chicken red blood cells AN - 41400132; 2056402 AU - Crippa, M P AU - Nickol, J M AU - Landsman, D AU - Bustin, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41400132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chromatin+structure+and+developmental+regulation+of+chromosomal+protein+HMG-17+gene+in+chicken+red+blood+cells&rft.au=Crippa%2C+M+P%3BNickol%2C+J+M%3BLandsman%2C+D%3BBustin%2C+M&rft.aulast=Crippa&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of laminin receptor expression by estrogen and progesterone in human breast cancer cell lines AN - 41399848; 2074498 AU - Castronovo, V AU - Taraboletti, G AU - Sobel, ME Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41399848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modulation+of+laminin+receptor+expression+by+estrogen+and+progesterone+in+human+breast+cancer+cell+lines&rft.au=Castronovo%2C+V%3BTaraboletti%2C+G%3BSobel%2C+ME&rft.aulast=Castronovo&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dexamethasone acts through a soluble factor to suppress secretion of histamine in rat basophilic leukemia (RBL-2H3) cells AN - 41397734; 2070571 AU - Collado-Escobar, D AU - O'Reilly, D AU - Ali, H AU - Beaven, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41397734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dexamethasone+acts+through+a+soluble+factor+to+suppress+secretion+of+histamine+in+rat+basophilic+leukemia+%28RBL-2H3%29+cells&rft.au=Collado-Escobar%2C+D%3BO%27Reilly%2C+D%3BAli%2C+H%3BBeaven%2C+MA&rft.aulast=Collado-Escobar&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specific unresponsiveness to donor antigens of mixed chimeras prepared by a nonlethal regimen AN - 41397529; 2120618 AU - Sharabi, Y AU - Sachs, D H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41397529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Specific+unresponsiveness+to+donor+antigens+of+mixed+chimeras+prepared+by+a+nonlethal+regimen&rft.au=Sharabi%2C+Y%3BSachs%2C+D+H&rft.aulast=Sharabi&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Re-examination of the kinetic evidence in support of the direct transfer mechanism in the glycolytic pathway AN - 41397484; 2075841 AU - Chock, P B AU - Gutfreund, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41397484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Re-examination+of+the+kinetic+evidence+in+support+of+the+direct+transfer+mechanism+in+the+glycolytic+pathway&rft.au=Chock%2C+P+B%3BGutfreund%2C+H&rft.aulast=Chock&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recognition of immunodominant T cell epitopes: Applications to vaccine design AN - 41397458; 2106570 AU - Berzofsky, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41397458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Recognition+of+immunodominant+T+cell+epitopes%3A+Applications+to+vaccine+design&rft.au=Berzofsky%2C+JA&rft.aulast=Berzofsky&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural changes in G proteins induced by pertussis toxin (PT) unrelated to ADP-ribosylation AN - 41396893; 2071285 AU - Ribeiro-Neto, F AU - Rodbell, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41396893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structural+changes+in+G+proteins+induced+by+pertussis+toxin+%28PT%29+unrelated+to+ADP-ribosylation&rft.au=Ribeiro-Neto%2C+F%3BRodbell%2C+M&rft.aulast=Ribeiro-Neto&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activated K-ras in 1,3 butadine-induced B63C3F1 mouse lung tumors AN - 41396494; 2077935 AU - Goodrow, T AU - Reynolds, S AU - Maronpot, R AU - Anderson, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41396494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Activated+K-ras+in+1%2C3+butadine-induced+B63C3F1+mouse+lung+tumors&rft.au=Goodrow%2C+T%3BReynolds%2C+S%3BMaronpot%2C+R%3BAnderson%2C+M&rft.aulast=Goodrow&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1133 Fifteenth Street, NW, Suite 1000, Washington, DC 20005 (USA), Price: $ 20.00 + $ 3.00 for postage and handling Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mice AN - 41396426; 2077923 AU - Anderson, L M AU - Hecht, S S AU - Hoffmann, D AU - Rice, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41396426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+the+transplacental+tumorigenicity+of+the+tobacco-specific+carcinogen%2C+4-%28methylnitrosamino%29-1-%283-pyridyl%29-1-butanone+%28NNK%29+in+mice&rft.au=Anderson%2C+L+M%3BHecht%2C+S+S%3BHoffmann%2C+D%3BRice%2C+J+M&rft.aulast=Anderson&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1133 Fifteenth Street, NW, Suite 1000, Washington, DC 20005 (USA), Price: $ 20.00 + $ 3.00 for postage and handling Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification, characterization and chromosomal localization of a functional gene from the large multigene family encoding the human non-histone chromosomal protein, HMG-17 AN - 41396218; 2056394 AU - Landsman, D AU - McBride, O W AU - Bustin, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41396218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification%2C+characterization+and+chromosomal+localization+of+a+functional+gene+from+the+large+multigene+family+encoding+the+human+non-histone+chromosomal+protein%2C+HMG-17&rft.au=Landsman%2C+D%3BMcBride%2C+O+W%3BBustin%2C+M&rft.aulast=Landsman&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions between clonal parathyroid epithelial (PT-r) and endothelial (BPE) cells: Evidence for structural and humoral correlates AN - 41395907; 2064370 AU - Brandi, M L AU - Sakaguchi, K AU - Ornberg, R L AU - Lelkes, P I AU - Aurbach, G D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41395907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interactions+between+clonal+parathyroid+epithelial+%28PT-r%29+and+endothelial+%28BPE%29+cells%3A+Evidence+for+structural+and+humoral+correlates&rft.au=Brandi%2C+M+L%3BSakaguchi%2C+K%3BOrnberg%2C+R+L%3BLelkes%2C+P+I%3BAurbach%2C+G+D&rft.aulast=Brandi&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of nitro blue tetrazolium reduction by pyrroline-5-carboxylate: Evidence for the transfer of oxidizing potential AN - 41395742; 2076251 AU - Phang, J M AU - Downing, S J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41395742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibition+of+nitro+blue+tetrazolium+reduction+by+pyrroline-5-carboxylate%3A+Evidence+for+the+transfer+of+oxidizing+potential&rft.au=Phang%2C+J+M%3BDowning%2C+S+J&rft.aulast=Phang&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of insulin-like growth factor-I-gene expression in human mononuclear phagocytes AN - 41395097; 2070926 AU - Trapnell, B C AU - Nagaoka, I AU - Nukiwa, T AU - Rom, W AU - Borok, Z AU - Crystal, R G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41395097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modulation+of+insulin-like+growth+factor-I-gene+expression+in+human+mononuclear+phagocytes&rft.au=Trapnell%2C+B+C%3BNagaoka%2C+I%3BNukiwa%2C+T%3BRom%2C+W%3BBorok%2C+Z%3BCrystal%2C+R+G&rft.aulast=Trapnell&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serological, clinical and salivary findings of primary Sjogren's syndrome AN - 41394890; 2062448 AU - Atkinson, J C AU - Fox, P C AU - Macynski, A AU - Pillemer Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41394890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Serological%2C+clinical+and+salivary+findings+of+primary+Sjogren%27s+syndrome&rft.au=Atkinson%2C+J+C%3BFox%2C+P+C%3BMacynski%2C+A%3BPillemer&rft.aulast=Atkinson&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AADR, 1111 14th Street, NW, Washington, DC 20005 (USA), Abstracts will be published in Journal of Dental Research. ISSN: 0022-0345 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - There are two low e sub(m) forms of mammalian cytochrome a sub(3) AN - 41394830; 2067567 AU - Hendler, R W AU - Sidhu, G S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41394830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=There+are+two+low+e+sub%28m%29+forms+of+mammalian+cytochrome+a+sub%283%29&rft.au=Hendler%2C+R+W%3BSidhu%2C+G+S&rft.aulast=Hendler&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis of inactive high-mannose type lipoprotein lipase in cultured brown adipocytes from cld/cld mice AN - 41393558; 2058756 AU - Masuno, H AU - Scow, RO Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41393558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Synthesis+of+inactive+high-mannose+type+lipoprotein+lipase+in+cultured+brown+adipocytes+from+cld%2Fcld+mice&rft.au=Masuno%2C+H%3BScow%2C+RO&rft.aulast=Masuno&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidants generated during EGF signaling targeted multiple protein disulfide isomerases in human A-431 cells AN - 41392450; 3381394 AU - Wu, Y L AU - Kang, S W AU - Levine, R L AU - Bourdi, M AU - Pohl, L AU - Rhee, S G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41392450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Oxidants+generated+during+EGF+signaling+targeted+multiple+protein+disulfide+isomerases+in+human+A-431+cells&rft.au=Wu%2C+Y+L%3BKang%2C+S+W%3BLevine%2C+R+L%3BBourdi%2C+M%3BPohl%2C+L%3BRhee%2C+S+G&rft.aulast=Wu&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike, Bethesda, MD 20814-3996, USA; phone: (301) 530-7145; fax: (301) 571-1824; email: asbmb@asbmb.faseb.org; Contact ASBMB for abstract & price info. Poster Paper No. M 984 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of multiple mRNAs for ADP-ribosylation factors (arfs ) in bovine tissues: Evidence for more than one ARF gene AN - 41391748; 2071211 AU - Tsuchiya, M AU - Price AU - Nightingale, M AU - Moss, J AU - Vaughan, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41391748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Identification+of+multiple+mRNAs+for+ADP-ribosylation+factors+%28arfs+%29+in+bovine+tissues%3A+Evidence+for+more+than+one+ARF+gene&rft.au=Tsuchiya%2C+M%3BPrice%3BNightingale%2C+M%3BMoss%2C+J%3BVaughan%2C+M&rft.aulast=Tsuchiya&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Properties of the ATP-dependent Clp protease from Escherichia coli AN - 41391230; 2052167 AU - Maurizi, M R AU - Kim, SH AU - Katayama, Y AU - Gottesman, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41391230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Properties+of+the+ATP-dependent+Clp+protease+from+Escherichia+coli&rft.au=Maurizi%2C+M+R%3BKim%2C+SH%3BKatayama%2C+Y%3BGottesman%2C+S&rft.aulast=Maurizi&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rabbit isozymes 2 and 5: Characterization and species-dependent expression in the kidney AN - 41390835; 2108119 AU - Ryan, R P AU - Gasser, R AU - Philpot, R M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41390835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rabbit+isozymes+2+and+5%3A+Characterization+and+species-dependent+expression+in+the+kidney&rft.au=Ryan%2C+R+P%3BGasser%2C+R%3BPhilpot%2C+R+M&rft.aulast=Ryan&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible mechanism of platelet-mediated cellular cholesterol accumulation AN - 41390702; 2123441 AU - Skarlatos, S AU - Rao, R AU - Chao, F-F AU - Kruth, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41390702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Possible+mechanism+of+platelet-mediated+cellular+cholesterol+accumulation&rft.au=Skarlatos%2C+S%3BRao%2C+R%3BChao%2C+F-F%3BKruth%2C+H&rft.aulast=Skarlatos&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural and possible functional consequences of the interaction between two glycolytic enzymes and F-Actin AN - 41390430; 2054208 AU - Lakatos, S AU - Chatelier, R C AU - Minton, A P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41390430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Structural+and+possible+functional+consequences+of+the+interaction+between+two+glycolytic+enzymes+and+F-Actin&rft.au=Lakatos%2C+S%3BChatelier%2C+R+C%3BMinton%2C+A+P&rft.aulast=Lakatos&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dermorphin gene-associated peptide (DGAP) is a selective delta -opioid receptor agonist AN - 41389772; 2062745 AU - Lazarus, L H AU - de Castiglione, R AU - Guglietta, A AU - Wilson, W E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41389772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dermorphin+gene-associated+peptide+%28DGAP%29+is+a+selective+delta+-opioid+receptor+agonist&rft.au=Lazarus%2C+L+H%3Bde+Castiglione%2C+R%3BGuglietta%2C+A%3BWilson%2C+W+E&rft.aulast=Lazarus&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cadmium induction of intraductal proliferative lesions in the dorsolateral prostate of noble rats AN - 41389103; 3364376 AU - Waalkes, M P AU - Anver, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41389103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cadmium+induction+of+intraductal+proliferative+lesions+in+the+dorsolateral+prostate+of+noble+rats&rft.au=Waalkes%2C+M+P%3BAnver%2C+M&rft.aulast=Waalkes&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 1600 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning of a second Acanthamoeba myosin I heavy chain gene: Evidence for the existence of at least three myosin I heavy chain protein isoforms AN - 41388435; 2061383 AU - Jung, G AU - Schmidt, C J AU - Hammer, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41388435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+of+a+second+Acanthamoeba+myosin+I+heavy+chain+gene%3A+Evidence+for+the+existence+of+at+least+three+myosin+I+heavy+chain+protein+isoforms&rft.au=Jung%2C+G%3BSchmidt%2C+C+J%3BHammer%2C+JA&rft.aulast=Jung&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - super(18)Ozone inhalation in rats: Relating absorbed dose, antioxidant concentrations and biological effects AN - 41385385; 3363117 AU - Hatch, GE AU - Norwood, J AU - Daniels, MJ AU - Crissman, K AU - Slade, R AU - Harris, L AU - McKee, J AU - Selgrade, MJK AU - Fari, F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41385385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=super%2818%29Ozone+inhalation+in+rats%3A+Relating+absorbed+dose%2C+antioxidant+concentrations+and+biological+effects&rft.au=Hatch%2C+GE%3BNorwood%2C+J%3BDaniels%2C+MJ%3BCrissman%2C+K%3BSlade%2C+R%3BHarris%2C+L%3BMcKee%2C+J%3BSelgrade%2C+MJK%3BFari%2C+F&rft.aulast=Hatch&rft.aufirst=GE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA, Abstracts available. Price $45. Poster Paper No. 344 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional consequences of the proteolytic removal of regulatory serines from the non-helical tail piece of Acanthamoeba myosin II AN - 41385111; 2054489 AU - Sathyamoorthy, V AU - Atkinson, MA AU - Korn, ED Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41385111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Functional+consequences+of+the+proteolytic+removal+of+regulatory+serines+from+the+non-helical+tail+piece+of+Acanthamoeba+myosin+II&rft.au=Sathyamoorthy%2C+V%3BAtkinson%2C+MA%3BKorn%2C+ED&rft.aulast=Sathyamoorthy&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethanol prevents down-regulation of cerebral beta-adrenoceptors caused by chronic administration of desipramine AN - 41385013; 2085858 AU - Turkka, J AU - Karanian, J AU - Gurguis, G AU - Potter, W Z AU - Linnoila, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41385013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ethanol+prevents+down-regulation+of+cerebral+beta-adrenoceptors+caused+by+chronic+administration+of+desipramine&rft.au=Turkka%2C+J%3BKaranian%2C+J%3BGurguis%2C+G%3BPotter%2C+W+Z%3BLinnoila%2C+M&rft.aulast=Turkka&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Elaine Galasso, ASCP&T, 1718 Gallagher Road, Norristown, PA 19401 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bypass of defective CD4 T helper cell function in HIV super(+) individuals by stimulation with alloantigens AN - 41383165; 2126891 AU - Shearer, G M AU - Clerici, M AU - Stocks, NI AU - Zajac, R A AU - Boswell, R N AU - Via, C S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41383165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Bypass+of+defective+CD4+T+helper+cell+function+in+HIV+super%28%2B%29+individuals+by+stimulation+with+alloantigens&rft.au=Shearer%2C+G+M%3BClerici%2C+M%3BStocks%2C+NI%3BZajac%2C+R+A%3BBoswell%2C+R+N%3BVia%2C+C+S&rft.aulast=Shearer&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA). Telephone: (301) 530-7020, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Localization of post-translational modifications of rhodopsin AN - 41379117; 2055769 AU - O'Brien, P J AU - St Jules, RJ AU - Smith, S B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41379117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Localization+of+post-translational+modifications+of+rhodopsin&rft.au=O%27Brien%2C+P+J%3BSt+Jules%2C+RJ%3BSmith%2C+S+B&rft.aulast=O%27Brien&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tri-o-cresyl phosphate (TOCP) toxicity to Sertoli cells in vitro requires leydig cells AN - 41375875; 2080667 AU - Chapin, R AU - Phelps, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41375875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tri-o-cresyl+phosphate+%28TOCP%29+toxicity+to+Sertoli+cells+in+vitro+requires+leydig+cells&rft.au=Chapin%2C+R%3BPhelps%2C+J&rft.aulast=Chapin&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1133 Fifteenth Street, NW, Suite 1000, Washington, DC 20005 (USA), Price: $ 20.00 + $ 3.00 for postage and handling Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transformation of Plasmodium falciparum with human dihydrofolate reductase renders them insensitive to WR99210 though does not affect proguanil AN - 41374426; 3361600 AU - Fidock, DA AU - Wellems, TE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41374426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transformation+of+Plasmodium+falciparum+with+human+dihydrofolate+reductase+renders+them+insensitive+to+WR99210+though+does+not+affect+proguanil&rft.au=Fidock%2C+DA%3BWellems%2C+TE&rft.aulast=Fidock&rft.aufirst=DA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASTMH, 60 Revere Drive, Suite 500, Northbrook, IL 60062, USA, Abstracts available. Price $10. Poster Paper No. 529 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of the asialoglycoprotein receptor in human hepatoma cells AN - 41369473; 2073589 AU - Weiss, P AU - Ashwell, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41369473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modulation+of+the+asialoglycoprotein+receptor+in+human+hepatoma+cells&rft.au=Weiss%2C+P%3BAshwell%2C+G&rft.aulast=Weiss&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thiophosphorylation causes Ca super(2+)-independent secretion of norepinephrine from permeabilized PC12 cells AN - 41365829; 2057171 AU - Vu, N D AU - Wagner, P D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41365829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Thiophosphorylation+causes+Ca+super%282%2B%29-independent+secretion+of+norepinephrine+from+permeabilized+PC12+cells&rft.au=Vu%2C+N+D%3BWagner%2C+P+D&rft.aulast=Vu&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of edited apolipoprotein B mRNAs in the rabbit and rat liver and intestine AN - 41365489; 2056643 AU - Tennyson, G AU - Sabatos, C AU - Eggerman, T AU - Hoeg, J M AU - Meng AU - Brewer, H B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41365489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+edited+apolipoprotein+B+mRNAs+in+the+rabbit+and+rat+liver+and+intestine&rft.au=Tennyson%2C+G%3BSabatos%2C+C%3BEggerman%2C+T%3BHoeg%2C+J+M%3BMeng%3BBrewer%2C+H+B&rft.aulast=Tennyson&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hormonal regulation of epidermal growth factor production in mouse submandibular gland and its plasma level AN - 41355407; 2070788 AU - Kasayama, S AU - Yoshimura, M AU - Oka, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41355407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hormonal+regulation+of+epidermal+growth+factor+production+in+mouse+submandibular+gland+and+its+plasma+level&rft.au=Kasayama%2C+S%3BYoshimura%2C+M%3BOka%2C+T&rft.aulast=Kasayama&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Crystal structure of the tetragonal form of creatine phosphokinase from rabbit muscle AN - 41338021; 3330067 AU - Mohana Rao, JK AU - Bujacz, G AU - Fritz-Wolf, K AU - Kabsch, W AU - Wlodawer, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:Chemistry and Chemical Engineering KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41338021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Crystal+structure+of+the+tetragonal+form+of+creatine+phosphokinase+from+rabbit+muscle&rft.au=Mohana+Rao%2C+JK%3BBujacz%2C+G%3BFritz-Wolf%2C+K%3BKabsch%2C+W%3BWlodawer%2C+A&rft.aulast=Mohana+Rao&rft.aufirst=JK&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Polycrystal Book Service, PO Box 3439, Dayton, OH 45401, Abstracts available. Price $10. Poster Paper No. P95 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Family study of psychiatric disorders associated with bulimia nervosa AN - 41328899; 1941463 AU - Kassett, JA AU - Maxwell, E M AU - Gershon, E S AU - Brandt, HA AU - Jimerson, D C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41328899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Family+study+of+psychiatric+disorders+associated+with+bulimia+nervosa&rft.au=Kassett%2C+JA%3BMaxwell%2C+E+M%3BGershon%2C+E+S%3BBrandt%2C+HA%3BJimerson%2C+D+C&rft.aulast=Kassett&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Office of Internationals Affairs, APA, 1400 K Street NW, Washington, DC 20005 (USA). Telephone: 202 682 6286. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suicide and environment in France AN - 41318747; 1941734 AU - Souetre, E AU - Wehr, T AU - Douillet, P AU - Rosenthal, N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41318747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Suicide+and+environment+in+France&rft.au=Souetre%2C+E%3BWehr%2C+T%3BDouillet%2C+P%3BRosenthal%2C+N&rft.aulast=Souetre&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Office of Internationals Affairs, APA, 1400 K Street NW, Washington, DC 20005 (USA). Telephone: 202 682 6286. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular modeling of Kai1, a transmembrane 4 superfamily protein AN - 41318680; 3325819 AU - Bienstock, R J AU - Barrett, J C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41318680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+modeling+of+Kai1%2C+a+transmembrane+4+superfamily+protein&rft.au=Bienstock%2C+R+J%3BBarrett%2C+J+C&rft.aulast=Bienstock&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Protein Society, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Price $24. Poster Paper No. 218-M N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular probes and assay reagents from marine dinoflagellate cell culture AN - 41309761; 3317986 AU - Baden, D G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41309761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+probes+and+assay+reagents+from+marine+dinoflagellate+cell+culture&rft.au=Baden%2C+D+G&rft.aulast=Baden&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In Vitro Cellular and Developmental Biology, 9315 Largo Drive West, Suite 255, Largo, MD 20774, Abstracts available. Paper No. I-6 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lung tumor induction in rats and mice from inhalation exposure to molybdenum trioxide AN - 41308885; 3303211 AU - Chan, P C AU - Herbert, R A AU - Chou, B J AU - Bucher, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41308885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lung+tumor+induction+in+rats+and+mice+from+inhalation+exposure+to+molybdenum+trioxide&rft.au=Chan%2C+P+C%3BHerbert%2C+R+A%3BChou%2C+B+J%3BBucher%2C+J+R&rft.aulast=Chan&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190, Attn: Nell Dillard, Abstracts available. Price $55. Poster Paper No. 889 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epitope mapping on HIV proteins by epitope excision and MALDI/MS AN - 41304239; 3325897 AU - Jeyarajah, S AU - Trojak, S K AU - Parker, CE AU - Sumner, M T AU - Beinstock, R AU - Tomer, K B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41304239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Epitope+mapping+on+HIV+proteins+by+epitope+excision+and+MALDI%2FMS&rft.au=Jeyarajah%2C+S%3BTrojak%2C+S+K%3BParker%2C+CE%3BSumner%2C+M+T%3BBeinstock%2C+R%3BTomer%2C+K+B&rft.aulast=Jeyarajah&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Protein Society, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Price $24. Poster Paper No. 296-T N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transforming growth factor (TGF)-beta and laminin, fibronectin, and collagen I in the developing mouse embryo AN - 41300887; 1872710 AU - Heine, U I AU - Munoz, E F AU - Roberts, AB AU - Sporn, M B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41300887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transforming+growth+factor+%28TGF%29-beta+and+laminin%2C+fibronectin%2C+and+collagen+I+in+the+developing+mouse+embryo&rft.au=Heine%2C+U+I%3BMunoz%2C+E+F%3BRoberts%2C+AB%3BSporn%2C+M+B&rft.aulast=Heine&rft.aufirst=U&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Publication, Sales and Distribution, National Research Council Canada, Ottawa, Canada K1A 0R6, ISBN No. 0-660-54182-3. Price: $25.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Triggers of myocardial ischemia during daily life: Results from the psychophysiological investigation of myocardial ischemia (PIMI) study AN - 41298930; 3311566 AU - Sheffield, D AU - Sheps, D S AU - Light, K C AU - Krantz, D S AU - Stone, PH AU - Raczynski, J AU - Kaufmann, P G AU - Forman, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41298930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Triggers+of+myocardial+ischemia+during+daily+life%3A+Results+from+the+psychophysiological+investigation+of+myocardial+ischemia+%28PIMI%29+study&rft.au=Sheffield%2C+D%3BSheps%2C+D+S%3BLight%2C+K+C%3BKrantz%2C+D+S%3BStone%2C+PH%3BRaczynski%2C+J%3BKaufmann%2C+P+G%3BForman%2C+S&rft.aulast=Sheffield&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Psychosomatic Society, 6728 Old McLean Village Drive, McLean, VA 22101-3906, Abstracts available. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibitory and immunoblotting monoclonal antibodies to human cytochrome P450 2D6 AN - 41298806; 3301746 AU - Krausz, K W AU - Shou, M AU - Gonzalez, F J AU - Gelboin, H V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41298806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibitory+and+immunoblotting+monoclonal+antibodies+to+human+cytochrome+P450+2D6&rft.au=Krausz%2C+K+W%3BShou%2C+M%3BGonzalez%2C+F+J%3BGelboin%2C+H+V&rft.aulast=Krausz&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401-2800. Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New NCI disease-oriented in vitro anti-cancer drug screening program AN - 41289003; 1866873 AU - Skehan, P AU - Scudeiro, D AU - Monks, A AU - Alley, M AU - McMahon, J AU - Vistica, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41289003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+NCI+disease-oriented+in+vitro+anti-cancer+drug+screening+program&rft.au=Skehan%2C+P%3BScudeiro%2C+D%3BMonks%2C+A%3BAlley%2C+M%3BMcMahon%2C+J%3BVistica%2C+D&rft.aulast=Skehan&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Publication, Sales and Distribution, National Research Council Canada, Ottawa, Canada K1A 0R6, ISBN No. 0-660-54182-3. Price: $25.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microinjected, intracellular insulin stimulates protein synthesis in an intact cell AN - 41274925; 1868724 AU - Miller, D S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41274925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Microinjected%2C+intracellular+insulin+stimulates+protein+synthesis+in+an+intact+cell&rft.au=Miller%2C+D+S&rft.aulast=Miller&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Publication, Sales and Distribution, National Research Council Canada, Ottawa, Canada K1A 0R6, ISBN No. 0-660-54182-3. Price: $25.00 Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - cis- and trans-acting control elements in the transcription of human globin genes AN - 41266925; 1839121 AU - Schechter, AN Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41266925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=cis-+and+trans-acting+control+elements+in+the+transcription+of+human+globin+genes&rft.au=Schechter%2C+AN&rft.aulast=Schechter&rft.aufirst=AN&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: VIDEOPRESS IOJ, Na okraji 9, 162 00 Prague 6 (Czechoslovakia), Abstracts will be published in 5 volumes. Price: 55.0 Sfrs Poster Paper No. FR: 330 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stabilization of binding of sperm maturation antigens by a Sertoli cell product AN - 41257892; 1816819 AU - Eddy, E M AU - Sile, H AU - McGee, R S AU - Toshimori, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41257892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stabilization+of+binding+of+sperm+maturation+antigens+by+a+Sertoli+cell+product&rft.au=Eddy%2C+E+M%3BSile%2C+H%3BMcGee%2C+R+S%3BToshimori%2C+K&rft.aulast=Eddy&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for the Study of Reproduction, 309 West Clark Street, Champaign, IL 61820 (USA). Telephone (217) 356-3182 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Participation of voltage-sensitive calcium channels in anterior pituitary hormone secretion AN - 41248064; 1756002 AU - Stojilkovic, S S AU - Izumi, S AU - Catt, K J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41248064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Participation+of+voltage-sensitive+calcium+channels+in+anterior+pituitary+hormone+secretion&rft.au=Stojilkovic%2C+S+S%3BIzumi%2C+S%3BCatt%2C+K+J&rft.aulast=Stojilkovic&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of accessory cell-derived costimulatory signals required for antigen-specific proliferation by type 1 T cell clones AN - 41244347; 1757579 AU - Jenkins, M K AU - Ashwell, J D AU - Schwartz, R H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41244347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+accessory+cell-derived+costimulatory+signals+required+for+antigen-specific+proliferation+by+type+1+T+cell+clones&rft.au=Jenkins%2C+M+K%3BAshwell%2C+J+D%3BSchwartz%2C+R+H&rft.aulast=Jenkins&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of IL-2/IL-2-R pathway in thymocyte maturation in vivo AN - 41244297; 1758346 AU - Tentori, L AU - Fowlkes, B J AU - Longo, D AU - Zuniga-Pfluecker, J C AU - Wing, C AU - Kruisbeek, A M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41244297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+IL-2%2FIL-2-R+pathway+in+thymocyte+maturation+in+vivo&rft.au=Tentori%2C+L%3BFowlkes%2C+B+J%3BLongo%2C+D%3BZuniga-Pfluecker%2C+J+C%3BWing%2C+C%3BKruisbeek%2C+A+M&rft.aulast=Tentori&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of naloxone on hypothalamic function and food intake in eating disorders AN - 41244001; 1757277 AU - Brandt, H AU - Hegg, A AU - Demitrack, M AU - Pigott, T AU - Gold, P AU - Obarzanek, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41244001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+naloxone+on+hypothalamic+function+and+food+intake+in+eating+disorders&rft.au=Brandt%2C+H%3BHegg%2C+A%3BDemitrack%2C+M%3BPigott%2C+T%3BGold%2C+P%3BObarzanek%2C+E&rft.aulast=Brandt&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of activation of an allospecific T cell hybridoma by genetically engineered soluble class I molecules AN - 41242711; 1757597 AU - Schneck, J AU - Margulies, D H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41242711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibition+of+activation+of+an+allospecific+T+cell+hybridoma+by+genetically+engineered+soluble+class+I+molecules&rft.au=Schneck%2C+J%3BMargulies%2C+D+H&rft.aulast=Schneck&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship of B2 expression to differentiation and cell cycle in an antigen-specific B cell line AN - 41242415; 1757902 AU - Pillemer AU - Tsokos, G C AU - Barbieri, S AU - Balow, JE AU - Golding, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41242415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Relationship+of+B2+expression+to+differentiation+and+cell+cycle+in+an+antigen-specific+B+cell+line&rft.au=Pillemer%3BTsokos%2C+G+C%3BBarbieri%2C+S%3BBalow%2C+JE%3BGolding%2C+B&rft.aulast=Pillemer&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Control of c-fms proto-oncogene expression in macrophage cell lines AN - 41240641; 1739368 AU - Gusella, G L AU - Cox, G W AU - Radzioch, D AU - Varesio, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41240641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Control+of+c-fms+proto-oncogene+expression+in+macrophage+cell+lines&rft.au=Gusella%2C+G+L%3BCox%2C+G+W%3BRadzioch%2C+D%3BVaresio%2C+L&rft.aulast=Gusella&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of feasibility of microencapsulation technology for the evaluation of anti-HIV drugs in vivo AN - 41238792; 1745754 AU - McMahon, JCamalier R AU - Shoemaker, R AU - Weislow, O AU - Kiser, R AU - Mayo, J AU - Fine, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41238792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+feasibility+of+microencapsulation+technology+for+the+evaluation+of+anti-HIV+drugs+in+vivo&rft.au=McMahon%2C+JCamalier+R%3BShoemaker%2C+R%3BWeislow%2C+O%3BKiser%2C+R%3BMayo%2C+J%3BFine%2C+D&rft.aulast=McMahon&rft.aufirst=JCamalier&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Missing signal on fixed antigen-producing cells AN - 41237724; 1762217 AU - Aiello, F B AU - Longo, D L AU - Durum, S K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41237724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Missing+signal+on+fixed+antigen-producing+cells&rft.au=Aiello%2C+F+B%3BLongo%2C+D+L%3BDurum%2C+S+K&rft.aulast=Aiello&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of increasing number of H-2 haplotypes on the secondary antigen-specific and allospecific proliferative T cell responses in allogeneic bone marrow chimeras AN - 41236979; 1758308 AU - Kovac, Z AU - Schwartz, R H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41236979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+increasing+number+of+H-2+haplotypes+on+the+secondary+antigen-specific+and+allospecific+proliferative+T+cell+responses+in+allogeneic+bone+marrow+chimeras&rft.au=Kovac%2C+Z%3BSchwartz%2C+R+H&rft.aulast=Kovac&rft.aufirst=Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - alpha l-antitrypsin deficiency caused by alpha l-antitrypsin null mattawa: An insertion mutation rendering the alpha l-antitrypsin gene incapable of producing alpha 1-antitrypsin AN - 41235857; 1723157 AU - Curiel, D AU - Brantly, M AU - Curiel, E AU - Stier, L AU - Crystal, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41235857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=alpha+l-antitrypsin+deficiency+caused+by+alpha+l-antitrypsin+null+mattawa%3A+An+insertion+mutation+rendering+the+alpha+l-antitrypsin+gene+incapable+of+producing+alpha+1-antitrypsin&rft.au=Curiel%2C+D%3BBrantly%2C+M%3BCuriel%2C+E%3BStier%2C+L%3BCrystal%2C+R&rft.aulast=Curiel&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Lung Association, 1740 Broadway, New York, NY 10019 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Na super(+) salicylate increases resistance of E. coli) to cephalosporins by decreased expression of Omp F porin AN - 41235330; 1736359 AU - Foulds, J AU - Rosner, J L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41235330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Na+super%28%2B%29+salicylate+increases+resistance+of+E.+coli%29+to+cephalosporins+by+decreased+expression+of+Omp+F+porin&rft.au=Foulds%2C+J%3BRosner%2C+J+L&rft.aulast=Foulds&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of phosphatidylinositol-anchored proteins in T cell activation AN - 41234861; 1762573 AU - Presky, D H AU - Low, M G AU - Shevach, E M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41234861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+phosphatidylinositol-anchored+proteins+in+T+cell+activation&rft.au=Presky%2C+D+H%3BLow%2C+M+G%3BShevach%2C+E+M&rft.aulast=Presky&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purification and characterization of a protein which binds to a conserved sequence in the human immunoglobulin Kappa enhancer AN - 41234612; 1765019 AU - Recker, D P AU - Gimble, J AU - Flanagan, J R AU - Max, EE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41234612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Purification+and+characterization+of+a+protein+which+binds+to+a+conserved+sequence+in+the+human+immunoglobulin+Kappa+enhancer&rft.au=Recker%2C+D+P%3BGimble%2C+J%3BFlanagan%2C+J+R%3BMax%2C+EE&rft.aulast=Recker&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of cAMP inducers on the activation of two murine helper T cell clones via the T cell receptor AN - 41234478; 1762127 AU - Taplits, M AU - DeBell, K AU - Hodes, R AU - Hoffman, T AU - Bonvini, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41234478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+cAMP+inducers+on+the+activation+of+two+murine+helper+T+cell+clones+via+the+T+cell+receptor&rft.au=Taplits%2C+M%3BDeBell%2C+K%3BHodes%2C+R%3BHoffman%2C+T%3BBonvini%2C+E&rft.aulast=Taplits&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myoglobin as model system for production of radical-mediated heme adducts of cytochrome P-450 AN - 41234044; 1747845 AU - Osawa, Y AU - Highet, RJ AU - Murphy, C M AU - Cotter, R J AU - Pohl, L R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41234044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Myoglobin+as+model+system+for+production+of+radical-mediated+heme+adducts+of+cytochrome+P-450&rft.au=Osawa%2C+Y%3BHighet%2C+RJ%3BMurphy%2C+C+M%3BCotter%2C+R+J%3BPohl%2C+L+R&rft.aulast=Osawa&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Further evidence for the dilution-dependent dissociation of native C1q AN - 41233175; 1764759 AU - Borsos, T AU - Hosoi, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41233175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Further+evidence+for+the+dilution-dependent+dissociation+of+native+C1q&rft.au=Borsos%2C+T%3BHosoi%2C+S&rft.aulast=Borsos&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cholera toxin greatly potentiates LPS-induced B cell proliferation and formation of IgA and IgG antibody AN - 41231927; 1744936 AU - Lycke, N AU - James, S P AU - Strober, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41231927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cholera+toxin+greatly+potentiates+LPS-induced+B+cell+proliferation+and+formation+of+IgA+and+IgG+antibody&rft.au=Lycke%2C+N%3BJames%2C+S+P%3BStrober%2C+W&rft.aulast=Lycke&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prostaglandin hydroperoxidase-dependent oxidation of phenylbutazone: Relationship to inhibition of prostaglandin cyclooxygenase AN - 41228845; 1760438 AU - Hughes, M F AU - Mason, R P AU - Eling, TE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41228845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prostaglandin+hydroperoxidase-dependent+oxidation+of+phenylbutazone%3A+Relationship+to+inhibition+of+prostaglandin+cyclooxygenase&rft.au=Hughes%2C+M+F%3BMason%2C+R+P%3BEling%2C+TE&rft.aulast=Hughes&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of lysis by LGL granule cytolysin: Separation into discrete binding and lytic stages AN - 41225075; 1732780 AU - Kuta, A E AU - Reynolds, DA AU - Henkart, P A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41225075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanism+of+lysis+by+LGL+granule+cytolysin%3A+Separation+into+discrete+binding+and+lytic+stages&rft.au=Kuta%2C+A+E%3BReynolds%2C+DA%3BHenkart%2C+P+A&rft.aulast=Kuta&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-1 and TNF participate in interferon-gamma-induced monocyte polykaryon formation AN - 41224889; 1744892 AU - Sechler, JMG AU - Gallin, JI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41224889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=IL-1+and+TNF+participate+in+interferon-gamma-induced+monocyte+polykaryon+formation&rft.au=Sechler%2C+JMG%3BGallin%2C+JI&rft.aulast=Sechler&rft.aufirst=JMG&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amplification of c-myc in human rhabdomyosarcoma: Lack of association with expression, histology, or biologic behavior AN - 41224413; 1743191 AU - Kouraklis, G AU - Triche, T J AU - Tsokos, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41224413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Amplification+of+c-myc+in+human+rhabdomyosarcoma%3A+Lack+of+association+with+expression%2C+histology%2C+or+biologic+behavior&rft.au=Kouraklis%2C+G%3BTriche%2C+T+J%3BTsokos%2C+M&rft.aulast=Kouraklis&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HL60 promyelocytic leukemia cells as a model for the development of cell-substrate adhesive and migratory ability AN - 41223690; 1761410 AU - Davis, GE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41223690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HL60+promyelocytic+leukemia+cells+as+a+model+for+the+development+of+cell-substrate+adhesive+and+migratory+ability&rft.au=Davis%2C+GE&rft.aulast=Davis&rft.aufirst=GE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of blood pH on oxygen consumption and hemodynamics during hypothermia in the dog AN - 41222853; 1753910 AU - Robbins, R C AU - Swain, JA AU - MacDonald, T J AU - Hampshire, V A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41222853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+blood+pH+on+oxygen+consumption+and+hemodynamics+during+hypothermia+in+the+dog&rft.au=Robbins%2C+R+C%3BSwain%2C+JA%3BMacDonald%2C+T+J%3BHampshire%2C+V+A&rft.aulast=Robbins&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation and characterization of a cDNA for male-specific P-450g from rat liver AN - 41221132; 1749605 AU - McClellan-Green, P AU - Negishi, M AU - Goldstein, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41221132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Isolation+and+characterization+of+a+cDNA+for+male-specific+P-450g+from+rat+liver&rft.au=McClellan-Green%2C+P%3BNegishi%2C+M%3BGoldstein%2C+JA&rft.aulast=McClellan-Green&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inconsistencies between molecular requirements for exocytosis of cytolytic granules and requirements for the "lethal hit" delivery by cytotoxic T lymphocytes AN - 41220476; 1732728 AU - Trenn, G AU - Takayama, H AU - Sitkovsky, M V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41220476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genes+encoding+the+beta+chain+of+the+T+cell+antigen+receptor+in+the+rabbit&rft.au=Kindt%2C+T+J%3BMarche%2C+P+N&rft.aulast=Kindt&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Atypical VHa2 phenotype of Alicia rabbits and its relationship to a VH-CH recombinant chromosome AN - 41219395; 1765025 AU - Newman, B AU - Kelus, A S AU - Mage, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41219395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Atypical+VHa2+phenotype+of+Alicia+rabbits+and+its+relationship+to+a+VH-CH+recombinant+chromosome&rft.au=Newman%2C+B%3BKelus%2C+A+S%3BMage%2C+R&rft.aulast=Newman&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Peroxidase-catalyzed oxidation of calcium chelator quin-2 and its analogs AN - 41217756; 1756008 AU - Van der Zee, J AU - Eling, TE AU - Mason, R P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41217756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Peroxidase-catalyzed+oxidation+of+calcium+chelator+quin-2+and+its+analogs&rft.au=Van+der+Zee%2C+J%3BEling%2C+TE%3BMason%2C+R+P&rft.aulast=Van+der+Zee&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrin usage by early thymocytes AN - 41214361; 3246457 AU - Mojcik, C F AU - Shevach, E M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41214361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Integrin+usage+by+early+thymocytes&rft.au=Mojcik%2C+C+F%3BShevach%2C+E+M&rft.aulast=Mojcik&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 274 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of oxidized amino acid residues using p-amino benzoic acid adducts AN - 41214358; 1760965 AU - Poston, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41214358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Detection+of+oxidized+amino+acid+residues+using+p-amino+benzoic+acid+adducts&rft.au=Poston%2C+J+M&rft.aulast=Poston&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automated procedure for generation of human LAK cells without lymphocyte separation AN - 41212409; 1739619 AU - Aebersold, P M AU - Carter, C S AU - Rosenberg, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41212409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Automated+procedure+for+generation+of+human+LAK+cells+without+lymphocyte+separation&rft.au=Aebersold%2C+P+M%3BCarter%2C+C+S%3BRosenberg%2C+SA&rft.aulast=Aebersold&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanistic and functional implications of biochemical studies of cytotoxic T lymphocyte activation AN - 41212102; 1753624 AU - Sitkovsky, M V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41212102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanistic+and+functional+implications+of+biochemical+studies+of+cytotoxic+T+lymphocyte+activation&rft.au=Sitkovsky%2C+M+V&rft.aulast=Sitkovsky&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lithium effects on pre- and post-synaptic noradrenergic measures AN - 41211437; 1685357 AU - Risby, E AU - Rudorfer, M AU - Moses, F AU - Zhou, D F AU - Hoffman, P AU - Potter, W Z Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41211437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lithium+effects+on+pre-+and+post-synaptic+noradrenergic+measures&rft.au=Risby%2C+E%3BRudorfer%2C+M%3BMoses%2C+F%3BZhou%2C+D+F%3BHoffman%2C+P%3BPotter%2C+W+Z&rft.aulast=Risby&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT Administrative Office, 1718 Gallagher Road, Norristown, PA 19401 (USA), Abstracts in Journal of Clinical Pharmacology and Therapeutics, vol. 43, no. 2, Feb 1988; booklet of abstracts $5.00 Abstract No. PPC-2 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CR1 receptor mediates entry of the metacyclic stage of Leishmania major promastogotes in human macrophages AN - 41211127; 1744986 AU - da Silva, RP AU - Hall, B F AU - Joiner, KA AU - Sacks, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41211127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=CR1+receptor+mediates+entry+of+the+metacyclic+stage+of+Leishmania+major+promastogotes+in+human+macrophages&rft.au=da+Silva%2C+RP%3BHall%2C+B+F%3BJoiner%2C+KA%3BSacks%2C+D+L&rft.aulast=da+Silva&rft.aufirst=RP&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Price: $75.00 (FASEB J. personal subscribers), $150.00 (FASEB J. institutional subscribers), $60.00 abstracts issues. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A prospective randomized comparison of 45% vs 25% branch chained amino acids (BCAA) in autologous marrow transplant (AMT) recipients AN - 41210183; 1704384 AU - Cromack, D AU - Peacock, J AU - Maher, M AU - Agent, S AU - White, D AU - Peter, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41210183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=A+prospective+randomized+comparison+of+45%25+vs+25%25+branch+chained+amino+acids+%28BCAA%29+in+autologous+marrow+transplant+%28AMT%29+recipients&rft.au=Cromack%2C+D%3BPeacock%2C+J%3BMaher%2C+M%3BAgent%2C+S%3BWhite%2C+D%3BPeter%2C+J&rft.aulast=Cromack&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: A.S.P.E.N., 8605 Cameron Street, Suite 500, Silver Spring, MD 20910 (USA), Abstracts in Journal of Parenteral & Enteral Nutrition, vol. 12, no. 1 supplement, Jan/Feb 1988 Abstract No. 1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Self-tuning voltage regulator for turbogenerators AN - 41207985; 1704100 AU - Zachariah, K J AU - Ham, PAL AU - Finch, J W AU - Farsi, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4000:ELECTRICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41207985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Self-tuning+voltage+regulator+for+turbogenerators&rft.au=Zachariah%2C+K+J%3BHam%2C+PAL%3BFinch%2C+J+W%3BFarsi%2C+M&rft.aulast=Zachariah&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institution of Electrical Engineers, Savoy Place, London WC2R 0BL (UK), Proceedings published in IEE Conference Publication No. 285 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calmodulin-dependent pathway for nuclear protein import that does not require GTP in vitro AN - 41204498; 3249176 AU - Sweitzer, T D AU - Hanover, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41204498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Calmodulin-dependent+pathway+for+nuclear+protein+import+that+does+not+require+GTP+in+vitro&rft.au=Sweitzer%2C+T+D%3BHanover%2C+JA&rft.aulast=Sweitzer&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2995 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - STAT-6-binding element in the IL-4 promoter AN - 41203652; 3247975 AU - Huang, H AU - Hu-Li, J AU - Ben-Sasson, S Z AU - Seder, R AU - Paul, W E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41203652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=STAT-6-binding+element+in+the+IL-4+promoter&rft.au=Huang%2C+H%3BHu-Li%2C+J%3BBen-Sasson%2C+S+Z%3BSeder%2C+R%3BPaul%2C+W+E&rft.aulast=Huang&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 1793 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selenium in normal and HIV-infected human T-cells: Selenocysteine in a C-terminal tripeptide of T-cell thioredoxin reductase corresponds to TGA in the gene AN - 41200337; 3247587 AU - Gladyshev, V N AU - Jeang, K-T AU - Stadtman, T C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41200337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Selenium+in+normal+and+HIV-infected+human+T-cells%3A+Selenocysteine+in+a+C-terminal+tripeptide+of+T-cell+thioredoxin+reductase+corresponds+to+TGA+in+the+gene&rft.au=Gladyshev%2C+V+N%3BJeang%2C+K-T%3BStadtman%2C+T+C&rft.aulast=Gladyshev&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 1405 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential susceptibility of T cell subsets to effects of extracellular adenosine and ATP: Possible role for purinergic receptors AN - 41199370; 3248025 AU - Apasov, S G AU - Koshiba, M AU - Chused, T M AU - Sitkovsky, M V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41199370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+susceptibility+of+T+cell+subsets+to+effects+of+extracellular+adenosine+and+ATP%3A+Possible+role+for+purinergic+receptors&rft.au=Apasov%2C+S+G%3BKoshiba%2C+M%3BChused%2C+T+M%3BSitkovsky%2C+M+V&rft.aulast=Apasov&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 1843 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetic and pharmacodynamic response to nicotine in naive subjects AN - 41199057; 1688351 AU - Blumhardt, CL AU - Newhouse, P A AU - Narang, P K AU - Nguyen, H T AU - Sunderland, T AU - Murphy, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41199057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pharmacokinetic+and+pharmacodynamic+response+to+nicotine+in+naive+subjects&rft.au=Blumhardt%2C+CL%3BNewhouse%2C+P+A%3BNarang%2C+P+K%3BNguyen%2C+H+T%3BSunderland%2C+T%3BMurphy%2C+D&rft.aulast=Blumhardt&rft.aufirst=CL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: ASCPT Administrative Office, 1718 Gallagher Road, Norristown, PA 19401 (USA), Abstracts in Journal of Clinical Pharmacology and Therapeutics, vol. 43, no. 2, Feb 1988; booklet of abstracts $5.00 Abstract No. IIB-4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HLA-A2/HTLV-1 tax peptide single-chain molecules are recognized by tax-specific and HLA-A2 allo-specific T cells AN - 41197965; 3247932 AU - Parker, K AU - Turner, R AU - Coligan, J AU - Biddison, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41197965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=HLA-A2%2FHTLV-1+tax+peptide+single-chain+molecules+are+recognized+by+tax-specific+and+HLA-A2+allo-specific+T+cells&rft.au=Parker%2C+K%3BTurner%2C+R%3BColigan%2C+J%3BBiddison%2C+W&rft.aulast=Parker&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 1750 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular potassium levels inhibit apoptotic DNA degradation AN - 41196169; 3246709 AU - Hughes, FM Jr AU - Purdy, G D AU - Cidlowski, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41196169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intracellular+potassium+levels+inhibit+apoptotic+DNA+degradation&rft.au=Hughes%2C+FM+Jr%3BPurdy%2C+G+D%3BCidlowski%2C+JA&rft.aulast=Hughes&rft.aufirst=FM&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 526 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transient up-regulation of the expression of p2y sub(2) purinergic receptors in thymocytes as an immediate early gene response AN - 41192934; 3248787 AU - Koshiba, M AU - Apasov, S AU - Sverdlov, V AU - Erb, L AU - Turner, J AU - Weisman, G AU - Sitkovsky, M V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41192934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transient+up-regulation+of+the+expression+of+p2y+sub%282%29+purinergic+receptors+in+thymocytes+as+an+immediate+early+gene+response&rft.au=Koshiba%2C+M%3BApasov%2C+S%3BSverdlov%2C+V%3BErb%2C+L%3BTurner%2C+J%3BWeisman%2C+G%3BSitkovsky%2C+M+V&rft.aulast=Koshiba&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2606 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric oxide oxidation of neurogranin attenuates its phosphorylation by protein kinase C and affinity for calmodulin AN - 41190089; 3248480 AU - Pak, J H AU - Mahoney, C W AU - Huang, F L AU - Huang, K-P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41190089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Nitric+oxide+oxidation+of+neurogranin+attenuates+its+phosphorylation+by+protein+kinase+C+and+affinity+for+calmodulin&rft.au=Pak%2C+J+H%3BMahoney%2C+C+W%3BHuang%2C+F+L%3BHuang%2C+K-P&rft.aulast=Pak&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2298 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New super(31)P NMR method to measure intracellular free [Mg super(2+)] AN - 41190087; 3249039 AU - Veech, R L AU - Kashiwaya, Y AU - Keon, CA AU - Radda, G K AU - Clarke, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41190087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+super%2831%29P+NMR+method+to+measure+intracellular+free+%5BMg+super%282%2B%29%5D&rft.au=Veech%2C+R+L%3BKashiwaya%2C+Y%3BKeon%2C+CA%3BRadda%2C+G+K%3BClarke%2C+K&rft.aulast=Veech&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 2858 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drosophila as a model to study the effects of selenium on aging, cancer and heart disease AN - 41189902; 3247087 AU - Park, SI AU - Lee, Byeong J AU - Hatfield, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41189902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Drosophila+as+a+model+to+study+the+effects+of+selenium+on+aging%2C+cancer+and+heart+disease&rft.au=Park%2C+SI%3BLee%2C+Byeong+J%3BHatfield%2C+D+L&rft.aulast=Park&rft.aufirst=SI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 904 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping of the rabbit MHC AN - 41189356; 3247202 AU - Han, M AU - Robinson, M AU - Kindt, T J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41189356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mapping+of+the+rabbit+MHC&rft.au=Han%2C+M%3BRobinson%2C+M%3BKindt%2C+T+J&rft.aulast=Han&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 1019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - E-cadherin-associated proteins and tyrosinephosphorylation status in Langerhans cell-like dendritic cells (FSDC) propagated from fetal murine skin AN - 41188705; 3247364 AU - Jacob, T AU - Udey, M C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41188705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=E-cadherin-associated+proteins+and+tyrosinephosphorylation+status+in+Langerhans+cell-like+dendritic+cells+%28FSDC%29+propagated+from+fetal+murine+skin&rft.au=Jacob%2C+T%3BUdey%2C+M+C&rft.aulast=Jacob&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 1182 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition by indomethacin of myeloperoxidase activity in pristane-elicited neutrophils AN - 41182001; 1645488 AU - Shacter, E AU - Pati, S AU - Potter, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41182001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibition+by+indomethacin+of+myeloperoxidase+activity+in+pristane-elicited+neutrophils&rft.au=Shacter%2C+E%3BPati%2C+S%3BPotter%2C+M&rft.aulast=Shacter&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Reticuloendothelial Society, c/o Dr. Sherwood M. Reichard, Medical College of Georgia, Augusta, GA 30912 (USA). Telephone: (404) 721-2601, Poster Paper No. 305 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase transformations in duplex stainless steel welds aged at 1050 degree C AN - 41176511; 1612098 AU - Honeyman, G A AU - Towers, T A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 6000:MATERIALS SCIENCE AND ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41176511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Phase+transformations+in+duplex+stainless+steel+welds+aged+at+1050+degree+C&rft.au=Honeyman%2C+G+A%3BTowers%2C+T+A&rft.aulast=Honeyman&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Institute of Metals, 1 Carlton House Terrace, London SW1Y 5DB (UK). Telephone: 01-839 4071. Telex: 8814813, Abstracts only available to those who attend the conference Paper No. 13 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cloning and expression of an O-linked UDP-GlcNAc transferase from C. elegans AN - 41175529; 3246802 AU - Lubas, WA AU - Hanover, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 1500:Biochemistry KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41175529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cloning+and+expression+of+an+O-linked+UDP-GlcNAc+transferase+from+C.+elegans&rft.au=Lubas%2C+WA%3BHanover%2C+J&rft.aulast=Lubas&rft.aufirst=WA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Federation of American Societies for Experimental Biology, 9650 Rockville Pike, Bethesda, MD 20814-3998, Abstracts available. Paper No. 619 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective attention in pregnancy and lactation AN - 41142208; 3236446 AU - Leong, Yung-Mei AU - Chaves, S AU - Wiggs, C AU - Plude, D AU - Altemus, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine KW - U 7500:Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41142208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Selective+attention+in+pregnancy+and+lactation&rft.au=Leong%2C+Yung-Mei%3BChaves%2C+S%3BWiggs%2C+C%3BPlude%2C+D%3BAltemus%2C+M&rft.aulast=Leong&rft.aufirst=Yung-Mei&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Psychiatric Press, Inc., 1400 K St., NW, Washington, DC 20005, Abstracts available. Paper No. NR79 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sulfated ganglioside expressed by oligodendrocyte progenitors is the most reactive glycolipid antigen for the A2B5 antibody AN - 41138338; 3225101 AU - Farrer, R G AU - Quarles, R H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:Chemistry and Chemical Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41138338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sulfated+ganglioside+expressed+by+oligodendrocyte+progenitors+is+the+most+reactive+glycolipid+antigen+for+the+A2B5+antibody&rft.au=Farrer%2C+R+G%3BQuarles%2C+R+H&rft.aulast=Farrer&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Neurochemistry, 301 University Boulevard, MRB 2.143, Galveston, TX 77555-1069, Abstracts and full papers available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Severe atypical neuropathy: An unexpected toxicity in patients with NHL treated with intensive chemotherapy and colony stimulating factors (CSFS) AN - 41132793; 3229064 AU - Adde, M AU - Venzon, D J AU - Magrath, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41132793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Severe+atypical+neuropathy%3A+An+unexpected+toxicity+in+patients+with+NHL+treated+with+intensive+chemotherapy+and+colony+stimulating+factors+%28CSFS%29&rft.au=Adde%2C+M%3BVenzon%2C+D+J%3BMagrath%2C+I&rft.aulast=Adde&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Oncology Nursing Society, 501 Holiday Drive, Pittsburgh, PA 15220-2749, Abstracts available. Price $4. Paper No. 37 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NF- Kappa B and interferon regulatory factor proteins physically interact and coordinately regulate major histocompatibility class I gene expression AN - 41125350; 3201309 AU - Drew, P D AU - Franzoso, G AU - Becker, K G AU - Biddison, W E AU - Siebenlist, U AU - Ozato, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41125350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=NF-+Kappa+B+and+interferon+regulatory+factor+proteins+physically+interact+and+coordinately+regulate+major+histocompatibility+class+I+gene+expression&rft.au=Drew%2C+P+D%3BFranzoso%2C+G%3BBecker%2C+K+G%3BBiddison%2C+W+E%3BSiebenlist%2C+U%3BOzato%2C+K&rft.aulast=Drew&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc., 2 Madison Avenue, Larchmont, NY 10538. Phone: 914-834-3100, Abstracts available. Paper No. P2-1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of dehydroepiandrosterone on MNU-induced breast cancer in rats AN - 41123829; 3201945 AU - Lubet, R A AU - Gordon, G M AU - Steele, V E AU - Kellofff, G J AU - Thomas, C F AU - Moon, R D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41123829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+dehydroepiandrosterone+on+MNU-induced+breast+cancer+in+rats&rft.au=Lubet%2C+R+A%3BGordon%2C+G+M%3BSteele%2C+V+E%3BKellofff%2C+G+J%3BThomas%2C+C+F%3BMoon%2C+R+D&rft.aulast=Lubet&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Cancer Therapy And Research Center, 8122 Datapoint Drive, Suite 600, San Antonio, TX 78229 Attn: Ms. Lois Dunnington, Abstracts available. Poster Paper No. 351 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of IRF-1 after IFN-gamma stimulation in T cells: Role of NF-kappa B family members AN - 41118667; 3201377 AU - Viggiano, V AU - Sica, A AU - Cippitelli, M AU - Eberly, K AU - Ghosh, P AU - Young, HA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41118667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+of+IRF-1+after+IFN-gamma+stimulation+in+T+cells%3A+Role+of+NF-kappa+B+family+members&rft.au=Viggiano%2C+V%3BSica%2C+A%3BCippitelli%2C+M%3BEberly%2C+K%3BGhosh%2C+P%3BYoung%2C+HA&rft.aulast=Viggiano&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc., 2 Madison Avenue, Larchmont, NY 10538. Phone: 914-834-3100, Abstracts available. Poster Paper No. W-8 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of interleukins 2, 12 and IFN- gamma upon murine squamous cell carcinoma in vitro and in vivo AN - 41115120; 3212123 AU - Chen, Z AU - Kiel, D AU - Van Waes, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41115120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+interleukins+2%2C+12+and+IFN-+gamma+upon+murine+squamous+cell+carcinoma+in+vitro+and+in+vivo&rft.au=Chen%2C+Z%3BKiel%2C+D%3BVan+Waes%2C+C&rft.aulast=Chen&rft.aufirst=Z&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Appleton & Lange, PO Box 118, Pearl River, NY 10965-9850, Selected abstracts available. Poster Paper No. P-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interferon- gamma transgenic mice: Analysis of alterations in leukocyte populations AN - 41104690; 3201458 AU - Reynolds, D AU - Kenny, J AU - Fisher, R AU - Grzegorzewski, K AU - Nestel, F AU - Gregorio, T AU - Komschlies, K AU - Young, HA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41104690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interferon-+gamma+transgenic+mice%3A+Analysis+of+alterations+in+leukocyte+populations&rft.au=Reynolds%2C+D%3BKenny%2C+J%3BFisher%2C+R%3BGrzegorzewski%2C+K%3BNestel%2C+F%3BGregorio%2C+T%3BKomschlies%2C+K%3BYoung%2C+HA&rft.aulast=Reynolds&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Mary Ann Liebert, Inc., 2 Madison Avenue, Larchmont, NY 10538. Phone: 914-834-3100, Abstracts available. Paper No. P3-1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Superagonists of recombinant human TSH provide a model of rational design of glycoprotein hormone analogs: Site-specific bovinization of the alpha subunit increases in vitro and in vivo bioactivity AN - 41079767; 3193019 AU - Szkudlinski, M W AU - Teh, NG AU - Grossmann, M AU - Tropea, JE AU - East-Palmer, J AU - Dacosta, C AU - Thotakura, N H AU - Weintraub, B D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41079767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Superagonists+of+recombinant+human+TSH+provide+a+model+of+rational+design+of+glycoprotein+hormone+analogs%3A+Site-specific+bovinization+of+the+alpha+subunit+increases+in+vitro+and+in+vivo+bioactivity&rft.au=Szkudlinski%2C+M+W%3BTeh%2C+NG%3BGrossmann%2C+M%3BTropea%2C+JE%3BEast-Palmer%2C+J%3BDacosta%2C+C%3BThotakura%2C+N+H%3BWeintraub%2C+B+D&rft.aulast=Szkudlinski&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Thyroid Association, Inc., Montefiore Medical Center, 111 East 210th, Room 311, Bronx, NY 10467, Abstracts available. N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased risk of myelodysplastic syndrome associated with glutathione S-transferase theta 1 gene defect AN - 41077760; 3192221 AU - Chen, H W AU - Sandler, D P AU - Taylor, JA AU - Watson, M AU - Shore, D L AU - Liu, E AU - Bloomfield, C D AU - Bell, DA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41077760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Increased+risk+of+myelodysplastic+syndrome+associated+with+glutathione+S-transferase+theta+1+gene+defect&rft.au=Chen%2C+H+W%3BSandler%2C+D+P%3BTaylor%2C+JA%3BWatson%2C+M%3BShore%2C+D+L%3BLiu%2C+E%3BBloomfield%2C+C+D%3BBell%2C+DA&rft.aulast=Chen&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Prague Institute of Advanced Studies, U Michelskeho lesa 366, 140 00 Prague 4, Czech Republic, Abstracts available. Poster Paper No. P2-3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Safety and efficacy of rotational atherectomy using a single burr (advanced slowly) followed by low pressure balloon angioplasty AN - 41051683; 3182044 AU - Shawl, F A AU - Efstratiou, A AU - Hussain, S AU - Quyyumi, A AU - Hoff, S B AU - Dougherty, K G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:Clinical Medicine KW - U 4500:Experimental Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41051683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Safety+and+efficacy+of+rotational+atherectomy+using+a+single+burr+%28advanced+slowly%29+followed+by+low+pressure+balloon+angioplasty&rft.au=Shawl%2C+F+A%3BEfstratiou%2C+A%3BHussain%2C+S%3BQuyyumi%2C+A%3BHoff%2C+S+B%3BDougherty%2C+K+G&rft.aulast=Shawl&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The European Heart House, 2035 Route des Colles, Les Tempiers, B.P. 179, 060903 Sophia Antipolis Cedex, France, Abstracts available. Poster Paper No. P2773 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hodgkin's disease: NCI trials addressing the remaining challenges AN - 41050728; 1567122 AU - Young, R C AU - Longo, D L AU - Glatstein, E AU - Hubbard, S AU - Duffey, P AU - DeVita, VT Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41050728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hodgkin%27s+disease%3A+NCI+trials+addressing+the+remaining+challenges&rft.au=Young%2C+R+C%3BLongo%2C+D+L%3BGlatstein%2C+E%3BHubbard%2C+S%3BDuffey%2C+P%3BDeVita%2C+VT+Jr&rft.aulast=Young&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Sponsor not indicated, Abstract No. 17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethanol affects cerebral cortical and cerebellar beta -adrenergic receptor function AN - 41048966; 1533082 AU - Valverius, P AU - Greene, J AU - Hoffman, P L AU - Tabakoff, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41048966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ethanol+affects+cerebral+cortical+and+cerebellar+beta+-adrenergic+receptor+function&rft.au=Valverius%2C+P%3BGreene%2C+J%3BHoffman%2C+P+L%3BTabakoff%2C+B&rft.aulast=Valverius&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2329 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation and characterization of cholesterol-containing particles released from thrombin-activated human blood platelets AN - 41048701; 1505010 AU - Skarlatos, SI AU - Chao, F-F AU - Gamble, W AU - Kruth, H S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41048701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Isolation+and+characterization+of+cholesterol-containing+particles+released+from+thrombin-activated+human+blood+platelets&rft.au=Skarlatos%2C+SI%3BChao%2C+F-F%3BGamble%2C+W%3BKruth%2C+H+S&rft.aulast=Skarlatos&rft.aufirst=SI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 563 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Further diversity in human class II antigens may be generated by isotypically-mixed alpha - beta pairs AN - 41046818; 1544741 AU - Sekaly, R P AU - Long, E O Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41046818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Further+diversity+in+human+class+II+antigens+may+be+generated+by+isotypically-mixed+alpha+-+beta+pairs&rft.au=Sekaly%2C+R+P%3BLong%2C+E+O&rft.aulast=Sekaly&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 5130 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A microvascular endothelial cell-derived mast cell proliferation factor AN - 41044123; 1548188 AU - Malone, D AU - Metcalfe, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41044123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=A+microvascular+endothelial+cell-derived+mast+cell+proliferation+factor&rft.au=Malone%2C+D%3BMetcalfe%2C+D&rft.aulast=Malone&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 6004 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Second site on cytochrome C T cell determinant that interacts with the Ia molecule AN - 41043502; 1541595 AU - Fox, B S AU - Carbone, F AU - Paterson, Y AU - Ronchese, F AU - Germain, R N AU - Schwartz, R H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41043502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Second+site+on+cytochrome+C+T+cell+determinant+that+interacts+with+the+Ia+molecule&rft.au=Fox%2C+B+S%3BCarbone%2C+F%3BPaterson%2C+Y%3BRonchese%2C+F%3BGermain%2C+R+N%3BSchwartz%2C+R+H&rft.aulast=Fox&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 4252 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of selective MAOIs on HVA/5HIAA ratio AN - 41041577; 1522726 AU - Potter, W AU - Risby, E AU - Sunderland, T AU - Hsiao, J AU - Rudorfer, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41041577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+selective+MAOIs+on+HVA%2F5HIAA+ratio&rft.au=Potter%2C+W%3BRisby%2C+E%3BSunderland%2C+T%3BHsiao%2C+J%3BRudorfer%2C+M&rft.aulast=Potter&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401 (USA). Telephone: (215) 825-3838, Abstract No. IIIB-5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of rH TNF, rm IFN-g, rH IL-2, and rm CSF-gm on stem cell activity in normal and leukopenic mice AN - 41039708; 1551747 AU - Schneider, M AU - Pennington, R AU - Talmadge, JE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41039708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+rH+TNF%2C+rm+IFN-g%2C+rH+IL-2%2C+and+rm+CSF-gm+on+stem+cell+activity+in+normal+and+leukopenic+mice&rft.au=Schneider%2C+M%3BPennington%2C+R%3BTalmadge%2C+JE&rft.aulast=Schneider&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 6967 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Psychoactive drugs affect HVA/5HIAA ratio AN - 41039528; 1522727 AU - Risby, E AU - Hsiao, J AU - Rudorfer, M AU - Potter, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41039528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Psychoactive+drugs+affect+HVA%2F5HIAA+ratio&rft.au=Risby%2C+E%3BHsiao%2C+J%3BRudorfer%2C+M%3BPotter%2C+W&rft.aulast=Risby&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401 (USA). Telephone: (215) 825-3838, Abstract No. IIIB-6 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cis-control elements of the human IL-2 gene AN - 41038998; 1538874 AU - Brunvand, M AU - Siebenlist, U Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41038998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cis-control+elements+of+the+human+IL-2+gene&rft.au=Brunvand%2C+M%3BSiebenlist%2C+U&rft.aulast=Brunvand&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 3678 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myc and p53 oncogene expression in human lung cancer cell lines AN - 41038717; 1533865 AU - Vinocour, M AU - Minna, J D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41038717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Myc+and+p53+oncogene+expression+in+human+lung+cancer+cell+lines&rft.au=Vinocour%2C+M%3BMinna%2C+J+D&rft.aulast=Vinocour&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2477 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor necrosis factor production by bone marrow-derived macrophages in response to lipopolysaccharide, lipid A and lipid X AN - 41037140; 1548987 AU - Sayers, T J AU - Macher, I AU - Chung, J AU - Kugler, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41037140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tumor+necrosis+factor+production+by+bone+marrow-derived+macrophages+in+response+to+lipopolysaccharide%2C+lipid+A+and+lipid+X&rft.au=Sayers%2C+T+J%3BMacher%2C+I%3BChung%2C+J%3BKugler%2C+E&rft.aulast=Sayers&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 6238 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Seleno-amino acid transfer ribonucleic acids AN - 41033413; 1527705 AU - Stadtman, T C AU - Ching, W-M AU - Wittwer, A J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41033413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Seleno-amino+acid+transfer+ribonucleic+acids&rft.au=Stadtman%2C+T+C%3BChing%2C+W-M%3BWittwer%2C+A+J&rft.aulast=Stadtman&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 1449 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transfection analysis of the contributions of Ti alpha - and beta -chains to T cell specificity AN - 41032654; 1541165 AU - Saito, T AU - Weiss, A AU - Miller, J AU - Germain, R N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41032654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transfection+analysis+of+the+contributions+of+Ti+alpha+-+and+beta+-chains+to+T+cell+specificity&rft.au=Saito%2C+T%3BWeiss%2C+A%3BMiller%2C+J%3BGermain%2C+R+N&rft.aulast=Saito&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 4132 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of a P75 IL-2 binding peptide to a high-affinity IL-2 receptor complex AN - 41031856; 1534587 AU - Tsudo, M AU - Kozak, R W AU - Goldman, C K AU - Waldmann, T A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41031856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Contribution+of+a+P75+IL-2+binding+peptide+to+a+high-affinity+IL-2+receptor+complex&rft.au=Tsudo%2C+M%3BKozak%2C+R+W%3BGoldman%2C+C+K%3BWaldmann%2C+T+A&rft.aulast=Tsudo&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2632 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of c-fos mRNA expression in fresh, terminally differentiated macrophages by activators of protein kinase AN - 41031375; 1541290 AU - Radzioch, D AU - Varesio, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41031375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+c-fos+mRNA+expression+in+fresh%2C+terminally+differentiated+macrophages+by+activators+of+protein+kinase&rft.au=Radzioch%2C+D%3BVaresio%2C+L&rft.aulast=Radzioch&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 4167 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of macrophage activation by infective and noninfective stages of Leishmania major promastigotes AN - 41030815; 1529256 AU - da Silva, R AU - Sacks, D L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41030815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modulation+of+macrophage+activation+by+infective+and+noninfective+stages+of+Leishmania+major+promastigotes&rft.au=da+Silva%2C+R%3BSacks%2C+D+L&rft.aulast=da+Silva&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 1770 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is body weight gain related to a reduced rate of energy expenditure? AN - 41029729; 1534100 AU - Ravussin, E AU - Lillioja, S AU - Abbott, W AU - Yki-Jarvinen, H AU - Christin, L AU - Freymond, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41029729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Is+body+weight+gain+related+to+a+reduced+rate+of+energy+expenditure%3F&rft.au=Ravussin%2C+E%3BLillioja%2C+S%3BAbbott%2C+W%3BYki-Jarvinen%2C+H%3BChristin%2C+L%3BFreymond%2C+D&rft.aulast=Ravussin&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2536 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New IL-2 receptor mediates high-dose IL-2-induced activation of resting human T cells AN - 41029513; 1534575 AU - Thuy, LTB AU - Dukovich, M AU - Peffer, N J AU - Kehrl, J H AU - Greene, W C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41029513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+IL-2+receptor+mediates+high-dose+IL-2-induced+activation+of+resting+human+T+cells&rft.au=Thuy%2C+LTB%3BDukovich%2C+M%3BPeffer%2C+N+J%3BKehrl%2C+J+H%3BGreene%2C+W+C&rft.aulast=Thuy&rft.aufirst=LTB&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2630 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Formyl peptide chemoattractant processing by cultured human umbilical vein endothelial cells AN - 41028951; 1534307 AU - Rotrosen, D AU - Malech, H L AU - Gallin, JI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41028951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Formyl+peptide+chemoattractant+processing+by+cultured+human+umbilical+vein+endothelial+cells&rft.au=Rotrosen%2C+D%3BMalech%2C+H+L%3BGallin%2C+JI&rft.aulast=Rotrosen&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2580 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular analysis of Ia structure and function AN - 41028935; 1551399 AU - Germain, R N AU - Braunstein, N S AU - Fox, B AU - Lechler, R I AU - Ronchese, F AU - Sant, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41028935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+analysis+of+Ia+structure+and+function&rft.au=Germain%2C+R+N%3BBraunstein%2C+N+S%3BFox%2C+B%3BLechler%2C+R+I%3BRonchese%2C+F%3BSant%2C+A&rft.aulast=Germain&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 6880 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytotoxic T lymphocytes in prevention of lupus-like disease occurring in murine graft-versus-host disease AN - 41028295; 1538132 AU - Via, C S AU - Sharrow, SO AU - Shearer, G M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41028295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytotoxic+T+lymphocytes+in+prevention+of+lupus-like+disease+occurring+in+murine+graft-versus-host+disease&rft.au=Via%2C+C+S%3BSharrow%2C+SO%3BShearer%2C+G+M&rft.aulast=Via&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 3499 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Western blot analysis of native C1 activation: Little self activation even in absence of C1-INH AN - 41027439; 1534760 AU - Hosoi, S AU - Circolo, A AU - Borsos, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41027439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Western+blot+analysis+of+native+C1+activation%3A+Little+self+activation+even+in+absence+of+C1-INH&rft.au=Hosoi%2C+S%3BCircolo%2C+A%3BBorsos%2C+T&rft.aulast=Hosoi&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 2672 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early biochemical events in the antigen-receptor regulated exocytosis in cytotoxic T lymphocytes AN - 41026070; 1525143 AU - Takayama, H AU - Sitkovsky, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41026070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Early+biochemical+events+in+the+antigen-receptor+regulated+exocytosis+in+cytotoxic+T+lymphocytes&rft.au=Takayama%2C+H%3BSitkovsky%2C+M&rft.aulast=Takayama&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 866 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Ml(ala super(213)) type of alpha 1-antitrypsin, a newly recognized, common "normal" alpha 1-antitrypsin haplotype AN - 41024952; 1507669 AU - Nukiwa, T AU - Brantly, M AU - Ogushi, F AU - Fells, G AU - Satoh, K AU - Stier, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41024952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+the+Ml%28ala+super%28213%29%29+type+of+alpha+1-antitrypsin%2C+a+newly+recognized%2C+common+%22normal%22+alpha+1-antitrypsin+haplotype&rft.au=Nukiwa%2C+T%3BBrantly%2C+M%3BOgushi%2C+F%3BFells%2C+G%3BSatoh%2C+K%3BStier%2C+L&rft.aulast=Nukiwa&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Lung Association, 1740 Broadway, New York, NY 10019 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions with tubulin of natural and synthetic analogs of the antimitotic agent combretastatin, a structure-activity study AN - 41023195; 1547730 AU - Lin, C M AU - Singh, S B AU - Chu, P S AU - Pettit, G R AU - Hamel, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41023195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interactions+with+tubulin+of+natural+and+synthetic+analogs+of+the+antimitotic+agent+combretastatin%2C+a+structure-activity+study&rft.au=Lin%2C+C+M%3BSingh%2C+S+B%3BChu%2C+P+S%3BPettit%2C+G+R%3BHamel%2C+E&rft.aulast=Lin&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 5869 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of graft-versus-host reaction on thymic function AN - 41022445; 1528913 AU - Fukuzawa, M AU - Shearer, G M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41022445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+graft-versus-host+reaction+on+thymic+function&rft.au=Fukuzawa%2C+M%3BShearer%2C+G+M&rft.aulast=Fukuzawa&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 1706 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of calcium binding proteins in rat cortex and in ammonium sulfate fractions of whole rat brain AN - 41022155; 1502186 AU - Creed, G J AU - Santer, D M AU - Heydorn, W E AU - Fukuda, T AU - Jacobowitz, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41022155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Detection+of+calcium+binding+proteins+in+rat+cortex+and+in+ammonium+sulfate+fractions+of+whole+rat+brain&rft.au=Creed%2C+G+J%3BSanter%2C+D+M%3BHeydorn%2C+W+E%3BFukuda%2C+T%3BJacobowitz%2C+D+M&rft.aulast=Creed&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 462 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible common mechanism for anthracycline-induced cardiotoxicity and antitumor effects AN - 41020728; 1504989 AU - Singh, Y AU - Krishna, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41020728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Possible+common+mechanism+for+anthracycline-induced+cardiotoxicity+and+antitumor+effects&rft.au=Singh%2C+Y%3BKrishna%2C+G&rft.aulast=Singh&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 542 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of neutrophil-induced cytostasis and cytotoxicity of YAC-1 cells by flow cytometry AN - 41020283; 1551564 AU - Ackermann, M F AU - Wiegand, G W AU - Luster, MI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41020283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Measurement+of+neutrophil-induced+cytostasis+and+cytotoxicity+of+YAC-1+cells+by+flow+cytometry&rft.au=Ackermann%2C+M+F%3BWiegand%2C+G+W%3BLuster%2C+MI&rft.aulast=Ackermann&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 6919 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evolution of murine immunoglobulin C lambda 2 and C lambda 4 genes AN - 41015439; 1525737 AU - Mami, F AU - Kindt, T J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/41015439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evolution+of+murine+immunoglobulin+C+lambda+2+and+C+lambda+4+genes&rft.au=Mami%2C+F%3BKindt%2C+T+J&rft.aulast=Mami&rft.aufirst=F&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Paper No. 1000 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sex difference in CHD mortality among diabetics: NHANES I epidemiologic followup study AN - 40996464; 1441670 AU - Donahue, R P AU - Moore, L AU - Kleinman, J AU - Harris, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40996464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sex+difference+in+CHD+mortality+among+diabetics%3A+NHANES+I+epidemiologic+followup+study&rft.au=Donahue%2C+R+P%3BMoore%2C+L%3BKleinman%2C+J%3BHarris%2C+M&rft.aulast=Donahue&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Heart Association, 7320 Greenville Avenue, Dallas, TX 75231 (USA), Abstract No. 1699 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serial changes in left ventricular function and reversal of dilatation after valve replacement for aortic regurgitation AN - 40994539; 1420511 AU - Bonow, RO AU - Dodd, J T AU - White, G G AU - Maron, B J AU - O'Gara, P T AU - McIntosh, CL Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40994539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Serial+changes+in+left+ventricular+function+and+reversal+of+dilatation+after+valve+replacement+for+aortic+regurgitation&rft.au=Bonow%2C+RO%3BDodd%2C+J+T%3BWhite%2C+G+G%3BMaron%2C+B+J%3BO%27Gara%2C+P+T%3BMcIntosh%2C+CL&rft.aulast=Bonow&rft.aufirst=RO&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Heart Association, 7320 Greenville Avenue, Dallas, TX 75231 (USA), Abstract No. 222 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution and characterization of two nonopiod peptides with morphine-modulating activity in the brain AN - 40912352; 1200745 AU - Majane, E A AU - Yang, H-YT Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40912352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distribution+and+characterization+of+two+nonopiod+peptides+with+morphine-modulating+activity+in+the+brain&rft.au=Majane%2C+E+A%3BYang%2C+H-YT&rft.aulast=Majane&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell lines with pre-B or pre-B/myeloid characteristics are generated by in vitro infection with retroviruses containing fes, ras, abl and src oncogenes AN - 40911224; 1201490 AU - Holmes, K L AU - Pierce, J H AU - Davidson, W F AU - Morse, HC III Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40911224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cell+lines+with+pre-B+or+pre-B%2Fmyeloid+characteristics+are+generated+by+in+vitro+infection+with+retroviruses+containing+fes%2C+ras%2C+abl+and+src+oncogenes&rft.au=Holmes%2C+K+L%3BPierce%2C+J+H%3BDavidson%2C+W+F%3BMorse%2C+HC+III&rft.aulast=Holmes&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Presence of interleukin 2 receptor (IL-2R) mRNA in mitogen-activated human B lymphocytes and its regulation by IL-2 AN - 40908298; 1199946 AU - Kehrl, J H AU - Peffer, N J AU - Greene, W L AU - Fauci, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40908298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Presence+of+interleukin+2+receptor+%28IL-2R%29+mRNA+in+mitogen-activated+human+B+lymphocytes+and+its+regulation+by+IL-2&rft.au=Kehrl%2C+J+H%3BPeffer%2C+N+J%3BGreene%2C+W+L%3BFauci%2C+A+S&rft.aulast=Kehrl&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 4904 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cadmium:zinc binding to metallothionein and renal cell injury AN - 40907272; 1189094 AU - Miller, C R AU - Zhu, S AU - Victery, W AU - Goyer, R A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40907272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cadmium%3Azinc+binding+to+metallothionein+and+renal+cell+injury&rft.au=Miller%2C+C+R%3BZhu%2C+S%3BVictery%2C+W%3BGoyer%2C+R+A&rft.aulast=Miller&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 2807 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse strain differences in induction of testosterone 16 alpha -hydroxylase isozyme by phenobarbital AN - 40905143; 1172455 AU - Ichikawa, T AU - Negishi, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40905143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mouse+strain+differences+in+induction+of+testosterone+16+alpha+-hydroxylase+isozyme+by+phenobarbital&rft.au=Ichikawa%2C+T%3BNegishi%2C+M&rft.aulast=Ichikawa&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Successful immunotherapy of established pulmonary metastases from weakly and nonimmunogenic sarcomas by systemic administration of high-dose recombinant interleukin 2: In vivo use of monoclonal antibodies to identify effector cells AN - 40904966; 1188761 AU - Mule, J J AU - Shu, S AU - Yang, J C AU - Rosenberg, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40904966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Successful+immunotherapy+of+established+pulmonary+metastases+from+weakly+and+nonimmunogenic+sarcomas+by+systemic+administration+of+high-dose+recombinant+interleukin+2%3A+In+vivo+use+of+monoclonal+antibodies+to+identify+effector+cells&rft.au=Mule%2C+J+J%3BShu%2C+S%3BYang%2C+J+C%3BRosenberg%2C+SA&rft.aulast=Mule&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of glutathione free radicals catalyzed by prostaglandin hydroperoxidase present in intact epidermal cells AN - 40898908; 1198630 AU - Schreiber, J AU - Mason, R P AU - Eling, TE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40898908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Detection+of+glutathione+free+radicals+catalyzed+by+prostaglandin+hydroperoxidase+present+in+intact+epidermal+cells&rft.au=Schreiber%2C+J%3BMason%2C+R+P%3BEling%2C+TE&rft.aulast=Schreiber&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 4530 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in hepatic cellular ploidy and estrogen receptor concentration following 17 alpha -ethynylestradiol-promoted hepatocarcinogenesis in rats AN - 40896289; 1198157 AU - Vickers, AEM AU - McCoy, Z AU - Lucier, G W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40896289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Changes+in+hepatic+cellular+ploidy+and+estrogen+receptor+concentration+following+17+alpha+-ethynylestradiol-promoted+hepatocarcinogenesis+in+rats&rft.au=Vickers%2C+AEM%3BMcCoy%2C+Z%3BLucier%2C+G+W&rft.aulast=Vickers&rft.aufirst=AEM&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular mechanisms in experimental autoimmune uveoretinitis studied with T cell lines AN - 40895029; 1170050 AU - Caspi, R R AU - Roberge, F G AU - McAllister, C G AU - Chan, C C AU - Kuwabara, T AU - Gery, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40895029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cellular+mechanisms+in+experimental+autoimmune+uveoretinitis+studied+with+T+cell+lines&rft.au=Caspi%2C+R+R%3BRoberge%2C+F+G%3BMcAllister%2C+C+G%3BChan%2C+C+C%3BKuwabara%2C+T%3BGery%2C+I&rft.aulast=Caspi&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 613 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of free intrasynaptosomal Ca super(2+) with the fluorescent Ca super(2+) chelators fura-2 and quin-2 AN - 40893528; 1186513 AU - Komulainen, H AU - Bondy, S C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40893528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Measurement+of+free+intrasynaptosomal+Ca+super%282%2B%29+with+the+fluorescent+Ca+super%282%2B%29+chelators+fura-2+and+quin-2&rft.au=Komulainen%2C+H%3BBondy%2C+S+C&rft.aulast=Komulainen&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 2086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel induction of graft-versus-host immunodeficiency across class I MHC disparity following infection with murine cytomegalovirus AN - 40892618; 1170285 AU - Via, C S AU - Shearer, G M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40892618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Novel+induction+of+graft-versus-host+immunodeficiency+across+class+I+MHC+disparity+following+infection+with+murine+cytomegalovirus&rft.au=Via%2C+C+S%3BShearer%2C+G+M&rft.aulast=Via&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 663 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biodistribution of monoclonal IgG, F(ab') sub(2) and Fab' following intravenous injection into mice AN - 40889163; 1170307 AU - Holton, OD III AU - Covell, D G AU - Black, CDV AU - Barbet, J AU - Parker, R J AU - Sieber, S M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40889163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biodistribution+of+monoclonal+IgG%2C+F%28ab%27%29+sub%282%29+and+Fab%27+following+intravenous+injection+into+mice&rft.au=Holton%2C+OD+III%3BCovell%2C+D+G%3BBlack%2C+CDV%3BBarbet%2C+J%3BParker%2C+R+J%3BSieber%2C+S+M&rft.aulast=Holton&rft.aufirst=OD&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 668 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biologic variation of HTLV-III/LAV isolates AN - 40888243; 1169880 AU - Kinter, A AU - Folks, T AU - Hidachi, A AU - Justement, S AU - McCoy, S AU - Martin, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40888243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biologic+variation+of+HTLV-III%2FLAV+isolates&rft.au=Kinter%2C+A%3BFolks%2C+T%3BHidachi%2C+A%3BJustement%2C+S%3BMcCoy%2C+S%3BMartin%2C+M&rft.aulast=Kinter&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 575 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activated platelets release unesterified cholesterol AN - 40887984; 1169183 AU - Kruth, H S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40887984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Activated+platelets+release+unesterified+cholesterol&rft.au=Kruth%2C+H+S&rft.aulast=Kruth&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: FASEB, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 442 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression and cloning of a transformation-regulated lysosomal protein AN - 40885883; 1146189 AU - Troen, B R AU - Rabin, M AU - Doherty, P AU - Gottesman, M M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40885883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Expression+and+cloning+of+a+transformation-regulated+lysosomal+protein&rft.au=Troen%2C+B+R%3BRabin%2C+M%3BDoherty%2C+P%3BGottesman%2C+M+M&rft.aulast=Troen&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 448 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multidrug resistance in human cancer cells is associated with increased expression of an amplified gene AN - 40882016; 1154437 AU - Fojo, A AU - Shen, D-W AU - Richert, N AU - Atlas, D AU - Cardarelli, C AU - Roninson, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40882016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Multidrug+resistance+in+human+cancer+cells+is+associated+with+increased+expression+of+an+amplified+gene&rft.au=Fojo%2C+A%3BShen%2C+D-W%3BRichert%2C+N%3BAtlas%2C+D%3BCardarelli%2C+C%3BRoninson%2C+I&rft.aulast=Fojo&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 1716 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arrangement of coiled-coil alpha -helices in intermediate filaments (IF) AN - 40873517; 1143663 AU - Steinert, P AU - Steven, A AU - Parry, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40873517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Arrangement+of+coiled-coil+alpha+-helices+in+intermediate+filaments+%28IF%29&rft.au=Steinert%2C+P%3BSteven%2C+A%3BParry%2C+D&rft.aulast=Steinert&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 41 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sparing of visual recognition after neonatal lesions of inferior temporal cortex in infant Rhesus monkeys AN - 40869990; 1132834 AU - Hagger, C AU - Brickson, M AU - Bachevalier, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40869990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sparing+of+visual+recognition+after+neonatal+lesions+of+inferior+temporal+cortex+in+infant+Rhesus+monkeys&rft.au=Hagger%2C+C%3BBrickson%2C+M%3BBachevalier%2C+J&rft.aulast=Hagger&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Divalent cation permeability of N-methyl-D-aspartate channels AN - 40868939; 1132690 AU - Mayer, M L AU - Westbrook, G L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40868939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Divalent+cation+permeability+of+N-methyl-D-aspartate+channels&rft.au=Mayer%2C+M+L%3BWestbrook%2C+G+L&rft.aulast=Mayer&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse acrosome-associated constituent identified with a monoclonal antibody AN - 40866491; 1152585 AU - O'Brien, DA AU - Gerton, G L AU - Eddy, E M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mouse+acrosome-associated+constituent+identified+with+a+monoclonal+antibody&rft.au=O%27Brien%2C+DA%3BGerton%2C+G+L%3BEddy%2C+E+M&rft.aulast=O%27Brien&rft.aufirst=DA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society for Cell Biology, 9650 Rockville Pike, Bethesda, MD 20814 (USA), Poster Paper No. 1376 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas AN - 40866243; 1135776 AU - Hill, J M AU - Lesniak, MA AU - Roth, J AU - Pert, C B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Autoradiographic+localization+of+insulin+receptors+in+rat+brain%3A+Prominence+in+olfactory+and+limbic+areas&rft.au=Hill%2C+J+M%3BLesniak%2C+MA%3BRoth%2C+J%3BPert%2C+C+B&rft.aulast=Hill&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of muscarinic stimulation on calcium mobilization phosphoinositide metabolism and transmitter release from PC12 cells AN - 40866128; 1133052 AU - Rabe, C S AU - Weight, F F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40866128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+muscarinic+stimulation+on+calcium+mobilization+phosphoinositide+metabolism+and+transmitter+release+from+PC12+cells&rft.au=Rabe%2C+C+S%3BWeight%2C+F+F&rft.aulast=Rabe&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High rate of glucose utilization in the fasciculus retroflexus in the brain of the conscious mouse AN - 40865511; 1136364 AU - Jay, T AU - Domer AU - Sokoloff, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40865511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=High+rate+of+glucose+utilization+in+the+fasciculus+retroflexus+in+the+brain+of+the+conscious+mouse&rft.au=Jay%2C+T%3BDomer%3BSokoloff%2C+L&rft.aulast=Jay&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies on proenkephalin gene expression in PC12 cells AN - 40861269; 1123135 AU - Byrd, JC III AU - Lindberg, I AU - Naranjo, J R AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40861269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Studies+on+proenkephalin+gene+expression+in+PC12+cells&rft.au=Byrd%2C+JC+III%3BLindberg%2C+I%3BNaranjo%2C+J+R%3BCosta%2C+E&rft.aulast=Byrd&rft.aufirst=JC&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Theory of multiple chemical signals in synaptic transmission as it emerges from GABA/benzodiazepine interactions AN - 40860023; 1103811 AU - Costa, E AU - Ferrero, P AU - Guidotti, A AU - Santi, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40860023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Theory+of+multiple+chemical+signals+in+synaptic+transmission+as+it+emerges+from+GABA%2Fbenzodiazepine+interactions&rft.au=Costa%2C+E%3BFerrero%2C+P%3BGuidotti%2C+A%3BSanti%2C+R&rft.aulast=Costa&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patterns of inhibition in auditory cortical cells of awake squirrel monkeys AN - 40859043; 1121884 AU - Symmes, D AU - Shamma, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40859043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Patterns+of+inhibition+in+auditory+cortical+cells+of+awake+squirrel+monkeys&rft.au=Symmes%2C+D%3BShamma%2C+S&rft.aulast=Symmes&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular cloning of cDNAs from differentially-expressed high and low abundance of mRNAs of differentiated and undifferentiated mouse neuroblastoma cells AN - 40857093; 1123121 AU - Schrier, B K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40857093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Molecular+cloning+of+cDNAs+from+differentially-expressed+high+and+low+abundance+of+mRNAs+of+differentiated+and+undifferentiated+mouse+neuroblastoma+cells&rft.au=Schrier%2C+B+K&rft.aulast=Schrier&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decreased fibroblast growth factor sensitivity of nerve growth factor-treated PC12 cells AN - 40855159; 1134659 AU - Kujita, K AU - Kuzuya, H AU - Guroff, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40855159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Decreased+fibroblast+growth+factor+sensitivity+of+nerve+growth+factor-treated+PC12+cells&rft.au=Kujita%2C+K%3BKuzuya%2C+H%3BGuroff%2C+G&rft.aulast=Kujita&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Society for Neuroscience, 11 Dupont Circle, N.W., Suite 130, Washington, DC 20036 (USA) N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of recurrent sarcomas with ifosfamide (IF) AN - 40839273; 1077276 AU - Magrath, I T AU - Sandlund, J T AU - Rayner, A AU - Rosenberg, SA AU - Arasi, V AU - Miser, J S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40839273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Treatment+of+recurrent+sarcomas+with+ifosfamide+%28IF%29&rft.au=Magrath%2C+I+T%3BSandlund%2C+J+T%3BRayner%2C+A%3BRosenberg%2C+SA%3BArasi%2C+V%3BMiser%2C+J+S&rft.aulast=Magrath&rft.aufirst=I&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oncogene amplification of c-myc and n-myc in cell lines established from patients with small cell lung cancer (SCLC) is associated with shortened survival AN - 40835478; 1078891 AU - Johnson, B E AU - Nau, M N AU - Gazdar, A F AU - Carney, D C AU - Oie, H K AU - Minna, J D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40835478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Oncogene+amplification+of+c-myc+and+n-myc+in+cell+lines+established+from+patients+with+small+cell+lung+cancer+%28SCLC%29+is+associated+with+shortened+survival&rft.au=Johnson%2C+B+E%3BNau%2C+M+N%3BGazdar%2C+A+F%3BCarney%2C+D+C%3BOie%2C+H+K%3BMinna%2C+J+D&rft.aulast=Johnson&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased sister chromatid exchange (SCE) in bone marrow and peripheral blood of young cigarette smokers AN - 40833795; 1073758 AU - Fine, R L AU - Kao-Shan, C S AU - Whang-Peng, J AU - Chabner, BA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40833795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Increased+sister+chromatid+exchange+%28SCE%29+in+bone+marrow+and+peripheral+blood+of+young+cigarette+smokers&rft.au=Fine%2C+R+L%3BKao-Shan%2C+C+S%3BWhang-Peng%2C+J%3BChabner%2C+BA&rft.aulast=Fine&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective systemic management of locally advanced breast cancer (LABC) AN - 40833233; 1075522 AU - Lippman, M AU - Sorace, R AU - Bagley, C AU - Lichter, A AU - Danforth, D AU - Wesley, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40833233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effective+systemic+management+of+locally+advanced+breast+cancer+%28LABC%29&rft.au=Lippman%2C+M%3BSorace%2C+R%3BBagley%2C+C%3BLichter%2C+A%3BDanforth%2C+D%3BWesley%2C+M&rft.aulast=Lippman&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advantages of early stopping rules for randomized trials (RT) in head and neck cancer AN - 40832170; 1077246 AU - Eisenberger, MA AU - Ellenberg, S S AU - Leyland-Jones, B AU - Friedman, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40832170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Advantages+of+early+stopping+rules+for+randomized+trials+%28RT%29+in+head+and+neck+cancer&rft.au=Eisenberger%2C+MA%3BEllenberg%2C+S+S%3BLeyland-Jones%2C+B%3BFriedman%2C+MA&rft.aulast=Eisenberger&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New and unusual retinal toxicity (RT) after high dose (HD) cisplatin (P) therapy for ovarian cancer (OC) AN - 40830461; 1074826 AU - Wilding, G AU - Caruso, R AU - Lawrence, T S AU - Ostchega, Y AU - Ballintine, E J AU - Ozols, R F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40830461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+and+unusual+retinal+toxicity+%28RT%29+after+high+dose+%28HD%29+cisplatin+%28P%29+therapy+for+ovarian+cancer+%28OC%29&rft.au=Wilding%2C+G%3BCaruso%2C+R%3BLawrence%2C+T+S%3BOstchega%2C+Y%3BBallintine%2C+E+J%3BOzols%2C+R+F&rft.aulast=Wilding&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase II trial of recombinant leukocyte A interferon (rIFN- sub( alpha )A) for advanced hairy cell leukemia AN - 40827996; 1079391 AU - Foon, KA AU - Maluish, A E AU - Abrams, P G AU - Wrighington, C S AU - Schnipper, E F AU - Herberman, R B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40827996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Phase+II+trial+of+recombinant+leukocyte+A+interferon+%28rIFN-+sub%28+alpha+%29A%29+for+advanced+hairy+cell+leukemia&rft.au=Foon%2C+KA%3BMaluish%2C+A+E%3BAbrams%2C+P+G%3BWrighington%2C+C+S%3BSchnipper%2C+E+F%3BHerberman%2C+R+B&rft.aulast=Foon&rft.aufirst=KA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selectivity in the action of recombinant TFNs on the susceptibility of K562 cells to NK cell-mediated lysis AN - 40823151; 1075808 AU - Gronberg, A AU - Reynolds, C W AU - Ortaldo, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40823151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Selectivity+in+the+action+of+recombinant+TFNs+on+the+susceptibility+of+K562+cells+to+NK+cell-mediated+lysis&rft.au=Gronberg%2C+A%3BReynolds%2C+C+W%3BOrtaldo%2C+J+R&rft.aulast=Gronberg&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Alan R. Liss, Inc., 41 East 11th Street, New York, NY 10003, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interleukin 1 (IL 1) as an autocrine signal: Evidence for the existence of specific IL 1 receptors on human Epstein Barr virus transformed B lymphocytes AN - 40822112; 1074316 AU - Matsushima, K AU - Tosato, G AU - Oppenheim, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40822112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interleukin+1+%28IL+1%29+as+an+autocrine+signal%3A+Evidence+for+the+existence+of+specific+IL+1+receptors+on+human+Epstein+Barr+virus+transformed+B+lymphocytes&rft.au=Matsushima%2C+K%3BTosato%2C+G%3BOppenheim%2C+J+J&rft.aulast=Matsushima&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Alan R. Liss, Inc., 41 East 11th Street, New York, NY 10003, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Database of selected air pollutants and their biological activities AN - 40819075; 1021132 AU - Kelsey, MI AU - Helmes, C T AU - Singh, H B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 8000:PHYSICS AND ASTRONOMY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40819075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Database+of+selected+air+pollutants+and+their+biological+activities&rft.au=Kelsey%2C+MI%3BHelmes%2C+C+T%3BSingh%2C+H+B&rft.aulast=Kelsey&rft.aufirst=MI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: No ordering information available at the present time, Abstract No. 683 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Subunit structure of membrane prolactin receptors from rat ovaries AN - 40814735; 1033876 AU - Mitani, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40814735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Subunit+structure+of+membrane+prolactin+receptors+from+rat+ovaries&rft.au=Mitani%2C+M&rft.aulast=Mitani&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular signals and neural peptide release: Unmasking by diacylglycerol of stimulatory cyclooxygenase and inhibitory lipoxygenase pathways modulating LHRH secretion AN - 40813567; 1033104 AU - Negro-Vilar, A AU - Conte, D AU - Valenca, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40813567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intracellular+signals+and+neural+peptide+release%3A+Unmasking+by+diacylglycerol+of+stimulatory+cyclooxygenase+and+inhibitory+lipoxygenase+pathways+modulating+LHRH+secretion&rft.au=Negro-Vilar%2C+A%3BConte%2C+D%3BValenca%2C+M&rft.aulast=Negro-Vilar&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biphasic inhibitory effect of corticosterone on CRF-induced ACTH release in cultured pituitary cells AN - 40810864; 1025930 AU - Samra, ABA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40810864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biphasic+inhibitory+effect+of+corticosterone+on+CRF-induced+ACTH+release+in+cultured+pituitary+cells&rft.au=Samra%2C+ABA&rft.aulast=Samra&rft.aufirst=ABA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anti-hCG antibodies enhance cAMP and progesterone production induced by deglycosylated hCG in granulosa cells AN - 40810769; 1035179 AU - Feng, P AU - Bartkiewicz, A AU - Chen, H C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40810769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tumor+necrosis+factor-alpha+%28TNF-alpha%29+directly+inhibits+and+indirectly+enhances+hematopoietic+progenitor+cell+proliferation%3A+Correlation+with+colony+stimulating+factor+%28CSF%29+receptor+modulation&rft.au=Keller%2C+J+R%3BRuscetti%2C+F+W%3BJacobsen%2C+SEW&rft.aulast=Keller&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Attenuation of the response of malic enzyme activity to glucose, insulin, dexamethasone and triiodothronine by growth hormone in primary cultures of adult rat hepatocytes AN - 40809662; 1036378 AU - Schaffer, W T AU - Mariash, C N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Attenuation+of+the+response+of+malic+enzyme+activity+to+glucose%2C+insulin%2C+dexamethasone+and+triiodothronine+by+growth+hormone+in+primary+cultures+of+adult+rat+hepatocytes&rft.au=Schaffer%2C+W+T%3BMariash%2C+C+N&rft.aulast=Schaffer&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Practical method for separation of radioactive impurities from steroid radioligands used in plasma protein binding studies AN - 40808851; 1031205 AU - Hiramatsu, R AU - Nisula, B C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40808851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Practical+method+for+separation+of+radioactive+impurities+from+steroid+radioligands+used+in+plasma+protein+binding+studies&rft.au=Hiramatsu%2C+R%3BNisula%2C+B+C&rft.aulast=Hiramatsu&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Leydig cell membrane phosphorylation: Implications for gonadotropic hormone action AN - 40807761; 1033945 AU - Winters, CA AU - Dufau, M L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Leydig+cell+membrane+phosphorylation%3A+Implications+for+gonadotropic+hormone+action&rft.au=Winters%2C+CA%3BDufau%2C+M+L&rft.aulast=Winters&rft.aufirst=CA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethanol decreases plasma beta-endorphin and pituitary pro-opiomelanocortin messenger RNA levels in the rat AN - 40806526; 1028974 AU - Dave, J R AU - Eiden, LE AU - Karanian, J W AU - Eskay, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40806526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ethanol+decreases+plasma+beta-endorphin+and+pituitary+pro-opiomelanocortin+messenger+RNA+levels+in+the+rat&rft.au=Dave%2C+J+R%3BEiden%2C+LE%3BKaranian%2C+J+W%3BEskay%2C+R+L&rft.aulast=Dave&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acquisition of estradiol-mediated regulatory mechanism of steroidogenesis in cultured fetal rat Leydig cells AN - 40806294; 1028558 AU - Tsai-Morris, CH AU - Knox, G AU - Luna, S AU - Ciocca, D AU - Dufau, M L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40806294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Acquisition+of+estradiol-mediated+regulatory+mechanism+of+steroidogenesis+in+cultured+fetal+rat+Leydig+cells&rft.au=Tsai-Morris%2C+CH%3BKnox%2C+G%3BLuna%2C+S%3BCiocca%2C+D%3BDufau%2C+M+L&rft.aulast=Tsai-Morris&rft.aufirst=CH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential release of corticotropin releasing factor and vasopressin from median eminences incubated in vitro AN - 40804668; 1034545 AU - Holmes, M C AU - Antoni, F A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40804668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+release+of+corticotropin+releasing+factor+and+vasopressin+from+median+eminences+incubated+in+vitro&rft.au=Holmes%2C+M+C%3BAntoni%2C+F+A&rft.aulast=Holmes&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cross reacting (common) tumor rejection antigens present on murine melanoma cells AN - 40798338; 0958153 AU - Hearing, V J AU - Vieira, W D AU - Law, L W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40798338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cross+reacting+%28common%29+tumor+rejection+antigens+present+on+murine+melanoma+cells&rft.au=Hearing%2C+V+J%3BVieira%2C+W+D%3BLaw%2C+L+W&rft.aulast=Hearing&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prolactin secretory dynamics in idiopathic precocious puberty and precocious puberty associated with hypothalamic hamartoma AN - 40797950; 1034346 AU - Uriarte, M AU - Pescovitz, OH AU - Barnes, K M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40797950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prolactin+secretory+dynamics+in+idiopathic+precocious+puberty+and+precocious+puberty+associated+with+hypothalamic+hamartoma&rft.au=Uriarte%2C+M%3BPescovitz%2C+OH%3BBarnes%2C+K+M&rft.aulast=Uriarte&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Endocrine Society, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proliferative helper T cells specific for a purified glycoprotein tumor transplantation antigen from Rauscher-MuLV induced tumors AN - 40796569; 0958190 AU - Swerdlow, R D AU - Bookman, M AU - Matis, L AU - Rogers, MJ Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40796569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Proliferative+helper+T+cells+specific+for+a+purified+glycoprotein+tumor+transplantation+antigen+from+Rauscher-MuLV+induced+tumors&rft.au=Swerdlow%2C+R+D%3BBookman%2C+M%3BMatis%2C+L%3BRogers%2C+MJ&rft.aulast=Swerdlow&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary retinol and carotene and risk of human lung cancer AN - 40791783; 0932827 AU - Ershow, A G AU - Ziegler, R G AU - Pickle, L W AU - Mason, T W AU - Buffler, P A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40791783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dietary+retinol+and+carotene+and+risk+of+human+lung+cancer&rft.au=Ershow%2C+A+G%3BZiegler%2C+R+G%3BPickle%2C+L+W%3BMason%2C+T+W%3BBuffler%2C+P+A&rft.aulast=Ershow&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory cells associated with acute bronchitis can damage the bronchial epithelium AN - 40791576; 0970089 AU - Willey, J C AU - Cantin, A AU - Crystal, R G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40791576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inflammatory+cells+associated+with+acute+bronchitis+can+damage+the+bronchial+epithelium&rft.au=Willey%2C+J+C%3BCantin%2C+A%3BCrystal%2C+R+G&rft.aulast=Willey&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Thoracic Society, Meetings and Conventions, 1740 Broadway, New York, NY 10019, USA, Abstracts published in April supplement issue of the American Review of Respiratory Diseases N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interleukin 2: Important co-factor in human B cell growth and differentiation AN - 40791518; 0931904 AU - Kehrl, J H AU - Grove, J H AU - Fauci, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40791518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interleukin+2%3A+Important+co-factor+in+human+B+cell+growth+and+differentiation&rft.au=Kehrl%2C+J+H%3BGrove%2C+J+H%3BFauci%2C+A+S&rft.aulast=Kehrl&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurophysiological approaches to a higher brain function AN - 40789004; 0979932 AU - Wise, S P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:MUTIDISCIPLINARY KW - U 3500:CLINICAL MEDICINE KW - U 2000:BIOLOGY GENERAL KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40789004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neurophysiological+approaches+to+a+higher+brain+function&rft.au=Wise%2C+S+P&rft.aulast=Wise&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: AAAS, 1515 Massachusetts Avenue, N.W., Washington, DC 20005, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Augmentation of adriamycin (AD), melphalan (ME), and cisplatin (CP) cytotoxicity (CT) by buthionine sulfoximine depletion of glutathione (GSH) in drug (D) resistant (R) human ovarian cancer (OC) cell lines (CL) AN - 40786368; 0958851 AU - Hamilton, T C AU - Winker, MA AU - Louie, K G AU - Batist, G AU - Fine, R L AU - Behrens, B C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40786368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Augmentation+of+adriamycin+%28AD%29%2C+melphalan+%28ME%29%2C+and+cisplatin+%28CP%29+cytotoxicity+%28CT%29+by+buthionine+sulfoximine+depletion+of+glutathione+%28GSH%29+in+drug+%28D%29+resistant+%28R%29+human+ovarian+cancer+%28OC%29+cell+lines+%28CL%29&rft.au=Hamilton%2C+T+C%3BWinker%2C+MA%3BLouie%2C+K+G%3BBatist%2C+G%3BFine%2C+R+L%3BBehrens%2C+B+C&rft.aulast=Hamilton&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of cigarette smoking on T-cell subsets in healthy subjects AN - 40786202; 0980721 AU - Tollerud, D J AU - Clark, J W AU - Brown, L M AU - Neuland, CY AU - Mann, D L AU - Hoover, R N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40786202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+cigarette+smoking+on+T-cell+subsets+in+healthy+subjects&rft.au=Tollerud%2C+D+J%3BClark%2C+J+W%3BBrown%2C+L+M%3BNeuland%2C+CY%3BMann%2C+D+L%3BHoover%2C+R+N&rft.aulast=Tollerud&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Thoracic Society, Meetings and Conventions, 1740 Broadway, New York, NY 10019, USA, Abstracts published in April supplement issue of the American Review of Respiratory Diseases N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spectrum of HTLV-related diseases AN - 40785494; 0944108 AU - Blattner, WA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40785494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Spectrum+of+HTLV-related+diseases&rft.au=Blattner%2C+WA&rft.aulast=Blattner&rft.aufirst=WA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - artial characterization of HTLV-III envelope and structural gene products AN - 40784488; 0959115 AU - Robey, W G AU - Fischinger, P J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40784488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=artial+characterization+of+HTLV-III+envelope+and+structural+gene+products&rft.au=Robey%2C+W+G%3BFischinger%2C+P+J&rft.aulast=Robey&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Establishment and characterization of a large comprehensive panel of cell lines demonstrates the diversity of human lung cancer AN - 40784119; 0949800 AU - Gazdar, A F AU - Oie, H AU - Russell, E AU - Carney, D N AU - Linnoila, I AU - Ruckdeschel, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40784119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Establishment+and+characterization+of+a+large+comprehensive+panel+of+cell+lines+demonstrates+the+diversity+of+human+lung+cancer&rft.au=Gazdar%2C+A+F%3BOie%2C+H%3BRussell%2C+E%3BCarney%2C+D+N%3BLinnoila%2C+I%3BRuckdeschel%2C+J&rft.aulast=Gazdar&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stable chromosome alterations associated with in vitro exposure of human fibroblasts to chemical or physical carcinogens AN - 40783723; 0949874 AU - Popescu, N C AU - Amsbaugh, S C AU - Milo, G AU - DiPaolo, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40783723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stable+chromosome+alterations+associated+with+in+vitro+exposure+of+human+fibroblasts+to+chemical+or+physical+carcinogens&rft.au=Popescu%2C+N+C%3BAmsbaugh%2C+S+C%3BMilo%2C+G%3BDiPaolo%2C+JA&rft.aulast=Popescu&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential metabolism of arachidonic acid in human lung cancer cell lines (HLCCL) AN - 40783063; 0948757 AU - Lau, S S AU - McMahon, J B AU - McMenamin, M G AU - Hubbard, W C AU - Schuller, H M AU - Boyd, M R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40783063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+metabolism+of+arachidonic+acid+in+human+lung+cancer+cell+lines+%28HLCCL%29&rft.au=Lau%2C+S+S%3BMcMahon%2C+J+B%3BMcMenamin%2C+M+G%3BHubbard%2C+W+C%3BSchuller%2C+H+M%3BBoyd%2C+M+R&rft.aulast=Lau&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic 5-methylcytosine determination by super(32)P post labeling analysis AN - 40782606; 0953773 AU - Wilson, V L AU - Smith, R A AU - Musci, DE AU - Autrup, H AU - Krokan, H AU - Harris, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40782606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genomic+5-methylcytosine+determination+by+super%2832%29P+post+labeling+analysis&rft.au=Wilson%2C+V+L%3BSmith%2C+R+A%3BMusci%2C+DE%3BAutrup%2C+H%3BKrokan%2C+H%3BHarris%2C+C+C&rft.aulast=Wilson&rft.aufirst=V&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequential analysis of chemically induced hepatoma development by two dimensional electrophoresis (2DE) AN - 40781663; 0951700 AU - Wirth, P J AU - Benjamin, T AU - Schwartz, D M AU - Thorgeirsson, S S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sequential+analysis+of+chemically+induced+hepatoma+development+by+two+dimensional+electrophoresis+%282DE%29&rft.au=Wirth%2C+P+J%3BBenjamin%2C+T%3BSchwartz%2C+D+M%3BThorgeirsson%2C+S+S&rft.aulast=Wirth&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 3-Deazaadenosine induces transformation and DNA hypomethylation in rat liver cells in culture AN - 40780658; 0953413 AU - Wilson, MJ AU - Bare, R M AU - Kwiecinski, ED AU - Poirier, LA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40780658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=3-Deazaadenosine+induces+transformation+and+DNA+hypomethylation+in+rat+liver+cells+in+culture&rft.au=Wilson%2C+MJ%3BBare%2C+R+M%3BKwiecinski%2C+ED%3BPoirier%2C+LA&rft.aulast=Wilson&rft.aufirst=MJ&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential control by serum factors of squamous differentiation in normal and malignant human bronchial epithelial cells AN - 40780096; 0943442 AU - Lechner, J F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40780096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+control+by+serum+factors+of+squamous+differentiation+in+normal+and+malignant+human+bronchial+epithelial+cells&rft.au=Lechner%2C+J+F&rft.aulast=Lechner&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered gene expression after neoplastic transformation of Syrian hamster cells by bisulfite (NaHSO sub(3)) AN - 40779889; 0951695 AU - DiPaolo, JA AU - Wirth, P J AU - Thorgeirsson, S S AU - Doniger, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40779889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Altered+gene+expression+after+neoplastic+transformation+of+Syrian+hamster+cells+by+bisulfite+%28NaHSO+sub%283%29%29&rft.au=DiPaolo%2C+JA%3BWirth%2C+P+J%3BThorgeirsson%2C+S+S%3BDoniger%2C+J&rft.aulast=DiPaolo&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transplantable pancreatic cancer tumor model in hamsters AN - 40779719; 0949647 AU - Sindelar, W F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40779719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Transplantable+pancreatic+cancer+tumor+model+in+hamsters&rft.au=Sindelar%2C+W+F&rft.aulast=Sindelar&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Strand breaks in mouse epidermal DNA are associated with phorbol ester induced differentiation AN - 40779533; 0953706 AU - Hartley, JA AU - Gibson, N W AU - Zwelling, LA AU - Yuspa, SH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40779533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Strand+breaks+in+mouse+epidermal+DNA+are+associated+with+phorbol+ester+induced+differentiation&rft.au=Hartley%2C+JA%3BGibson%2C+N+W%3BZwelling%2C+LA%3BYuspa%2C+SH&rft.aulast=Hartley&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genes encoding the beta chain of the T cell antigen receptor in the rabbit AN - 40778889; 0944523 AU - Kindt, T J AU - Marche, P N Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40778889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Genes+encoding+the+beta+chain+of+the+T+cell+antigen+receptor+in+the+rabbit&rft.au=Kindt%2C+T+J%3BMarche%2C+P+N&rft.aulast=Kindt&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary toxicity (PT) with combined modality therapy for limited stage small cell lung cancer (SCLC) AN - 40778130; 0954505 AU - Brooks, B AU - Seifter, E AU - Walsh, T AU - Zabell, A AU - Johnston-Early, A AU - Makuch, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40778130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pulmonary+toxicity+%28PT%29+with+combined+modality+therapy+for+limited+stage+small+cell+lung+cancer+%28SCLC%29&rft.au=Brooks%2C+B%3BSeifter%2C+E%3BWalsh%2C+T%3BZabell%2C+A%3BJohnston-Early%2C+A%3BMakuch%2C+R&rft.aulast=Brooks&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential production of B cell stimulatory factors by T cell lines AN - 40777455; 0931767 AU - Ennist, D L AU - Bottomly, K AU - Howard, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40777455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differential+production+of+B+cell+stimulatory+factors+by+T+cell+lines&rft.au=Ennist%2C+D+L%3BBottomly%2C+K%3BHoward%2C+M&rft.aulast=Ennist&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism to CO sub(2) by hepatocytes from Fischer rats AN - 40776306; 0953046 AU - Farrelly, J G AU - Stewart, M L AU - Hecker, LI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40776306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Metabolism+to+CO+sub%282%29+by+hepatocytes+from+Fischer+rats&rft.au=Farrelly%2C+J+G%3BStewart%2C+M+L%3BHecker%2C+LI&rft.aulast=Farrelly&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is the exaggerated helper T cell alveolitis of sarcoidosis associated with an inability of T suppressor cells to proliferate? AN - 40775979; 0970842 AU - Saltini, C AU - Spurzem, J R AU - Crystal, R G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Is+the+exaggerated+helper+T+cell+alveolitis+of+sarcoidosis+associated+with+an+inability+of+T+suppressor+cells+to+proliferate%3F&rft.au=Saltini%2C+C%3BSpurzem%2C+J+R%3BCrystal%2C+R+G&rft.aulast=Saltini&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Thoracic Society, Meetings and Conventions, 1740 Broadway, New York, NY 10019, USA, Abstracts published in April supplement issue of the American Review of Respiratory Diseases N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of fetal risk for transplacental carcinogenesis by fetal and maternal genotype for inducibility of aryl hydrocarbon metabolism AN - 40775962; 0952951 AU - Anderson, L M AU - Jones, AB Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Determination+of+fetal+risk+for+transplacental+carcinogenesis+by+fetal+and+maternal+genotype+for+inducibility+of+aryl+hydrocarbon+metabolism&rft.au=Anderson%2C+L+M%3BJones%2C+AB&rft.aulast=Anderson&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunocytochemical localization of Ras super(Ha) p21 in fixed tissue sections of experimentally induced tumors of mice and rats AN - 40775492; 0950549 AU - Ward, J M AU - Pardue, R AU - Takahashi, K AU - Shih, T AU - Weislow, O Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunocytochemical+localization+of+Ras+super%28Ha%29+p21+in+fixed+tissue+sections+of+experimentally+induced+tumors+of+mice+and+rats&rft.au=Ward%2C+J+M%3BPardue%2C+R%3BTakahashi%2C+K%3BShih%2C+T%3BWeislow%2C+O&rft.aulast=Ward&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of enkephalin precursor messenger RNA content of neuroblastoma x glioma hybrid cells by glucocorticoids and cAMP AN - 40775277; 0895894 AU - Sabol, S L AU - Yoshikawa, K Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+enkephalin+precursor+messenger+RNA+content+of+neuroblastoma+x+glioma+hybrid+cells+by+glucocorticoids+and+cAMP&rft.au=Sabol%2C+S+L%3BYoshikawa%2C+K&rft.aulast=Sabol&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduction of arsenazo III and antipyrylazo III to their free radical metabolites by mitochondrial and cytoplasmic enzymes AN - 40775068; 0939495 AU - Docampo, R AU - Mason, R P AU - Moreno, SNJ Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Reduction+of+arsenazo+III+and+antipyrylazo+III+to+their+free+radical+metabolites+by+mitochondrial+and+cytoplasmic+enzymes&rft.au=Docampo%2C+R%3BMason%2C+R+P%3BMoreno%2C+SNJ&rft.aulast=Docampo&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phorbol esters inhibit short circuit current in A6 epithelia AN - 40775034; 0911533 AU - Yanase, M AU - Handler, J S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Phorbol+esters+inhibit+short+circuit+current+in+A6+epithelia&rft.au=Yanase%2C+M%3BHandler%2C+J+S&rft.aulast=Yanase&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of retinoic acid on proliferation and calcium induced differentiation of papilloma cell lines AN - 40774265; 0953741 AU - Lichti, U AU - Nagae, S AU - Ben, T AU - Hennings, H AU - Yuspa, SH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40774265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+retinoic+acid+on+proliferation+and+calcium+induced+differentiation+of+papilloma+cell+lines&rft.au=Lichti%2C+U%3BNagae%2C+S%3BBen%2C+T%3BHennings%2C+H%3BYuspa%2C+SH&rft.aulast=Lichti&rft.aufirst=U&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ectopic human chorionic gonadotropin production by cultured lung carcinoma cells AN - 40772302; 0955532 AU - Boman, B M AU - Mark, GE AU - Siegel, M AU - Harris, C C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40772302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ectopic+human+chorionic+gonadotropin+production+by+cultured+lung+carcinoma+cells&rft.au=Boman%2C+B+M%3BMark%2C+GE%3BSiegel%2C+M%3BHarris%2C+C+C&rft.aulast=Boman&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radioimmunotherapy of malignant human T cell lines with super(125)I-T101 monoclonal antibody AN - 40772089; 0957643 AU - Boven, E AU - Lindmo, T AU - Mitchell, J AU - Bunn, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40772089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Radioimmunotherapy+of+malignant+human+T+cell+lines+with+super%28125%29I-T101+monoclonal+antibody&rft.au=Boven%2C+E%3BLindmo%2C+T%3BMitchell%2C+J%3BBunn%2C+P&rft.aulast=Boven&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma therapy of primary rat mammary carcinoma: Activation of the alternative complement pathway during absorption of plasma with sepharose derivatives is dependent on the anticoagulant AN - 40771931; 0957390 AU - Nakanishi, K AU - Zbar, B AU - Borsos, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Plasma+therapy+of+primary+rat+mammary+carcinoma%3A+Activation+of+the+alternative+complement+pathway+during+absorption+of+plasma+with+sepharose+derivatives+is+dependent+on+the+anticoagulant&rft.au=Nakanishi%2C+K%3BZbar%2C+B%3BBorsos%2C+T&rft.aulast=Nakanishi&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of vitamin K sub(1) on prostacyclin synthesis by cultured bovine aortic endothelial cells AN - 40770384; 0943447 AU - Nolan, R D AU - Eling, TE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40770384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+vitamin+K+sub%281%29+on+prostacyclin+synthesis+by+cultured+bovine+aortic+endothelial+cells&rft.au=Nolan%2C+R+D%3BEling%2C+TE&rft.aulast=Nolan&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introductory remarks AN - 40769111; 0928994 AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Introductory+remarks&rft.au=Costa%2C+E&rft.aulast=Costa&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein kinase C and endogenous substrates in preneoplastic mouse epidermal cell lines AN - 40768518; 0953694 AU - Gindhart, T D AU - Smith, B M AU - Colburn, N H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Protein+kinase+C+and+endogenous+substrates+in+preneoplastic+mouse+epidermal+cell+lines&rft.au=Gindhart%2C+T+D%3BSmith%2C+B+M%3BColburn%2C+N+H&rft.aulast=Gindhart&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Association for Cancer Research, Temple University of Medicine, West Building, Room 301, Broad and Tioga Streets, Philadelphia, PA 19140 (USA), Request Volume 26, March 1985 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of P-450b and its mRNA by 5-t-butyl-1,3-benzodioxole and its methylene disubstituted analog: Repression of this induction by coadministration of 3-methylcholanthrene AN - 40768264; 0929359 AU - Yeowell, H N AU - Linko, P AU - Hodgson, E AU - Goldstein, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+P-450b+and+its+mRNA+by+5-t-butyl-1%2C3-benzodioxole+and+its+methylene+disubstituted+analog%3A+Repression+of+this+induction+by+coadministration+of+3-methylcholanthrene&rft.au=Yeowell%2C+H+N%3BLinko%2C+P%3BHodgson%2C+E%3BGoldstein%2C+JA&rft.aulast=Yeowell&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - C3 deposition and cleavage on epimastigotes and metacyclic trypomastigotes of Trypanosoma cruzi AN - 40767654; 0928484 AU - Joiner, KA AU - Sher, A AU - Kirchhoff, LV AU - Gaither, T AU - Hammer, CH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=C3+deposition+and+cleavage+on+epimastigotes+and+metacyclic+trypomastigotes+of+Trypanosoma+cruzi&rft.au=Joiner%2C+KA%3BSher%2C+A%3BKirchhoff%2C+LV%3BGaither%2C+T%3BHammer%2C+CH&rft.aulast=Joiner&rft.aufirst=KA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Partitioning of renal zinc between metallothionein and ethylene-diaminetetraacetic acid (EDTA) during treatment of rats with Na sub(2)Ca EDTA AN - 40767433; 0922615 AU - Zhu, S AU - Miller, C R AU - Victery, W AU - Goyer, R A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Partitioning+of+renal+zinc+between+metallothionein+and+ethylene-diaminetetraacetic+acid+%28EDTA%29+during+treatment+of+rats+with+Na+sub%282%29Ca+EDTA&rft.au=Zhu%2C+S%3BMiller%2C+C+R%3BVictery%2C+W%3BGoyer%2C+R+A&rft.aulast=Zhu&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of protein synthesis as a mechanism of tunicamycin induced decrease in liver cytochrome P-450 AN - 40767220; 0935742 AU - Singh, Y AU - Shirhatti, V AU - Liu, C T AU - Feller AU - Krishna, G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inhibition+of+protein+synthesis+as+a+mechanism+of+tunicamycin+induced+decrease+in+liver+cytochrome+P-450&rft.au=Singh%2C+Y%3BShirhatti%2C+V%3BLiu%2C+C+T%3BFeller%3BKrishna%2C+G&rft.aulast=Singh&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - T cell-dependent Ia expression on B cells AN - 40766921; 0921897 AU - Tartakovsky, R AU - Durum, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=T+cell-dependent+Ia+expression+on+B+cells&rft.au=Tartakovsky%2C+R%3BDurum%2C+S&rft.aulast=Tartakovsky&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ouabain-sensitive components of brain Na super(+), K super(+)-ATPase: Effects of ethanol AN - 40766614; 0930447 AU - Nhamburo, P T AU - Hoffman, P L AU - Tabakoff, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ouabain-sensitive+components+of+brain+Na+super%28%2B%29%2C+K+super%28%2B%29-ATPase%3A+Effects+of+ethanol&rft.au=Nhamburo%2C+P+T%3BHoffman%2C+P+L%3BTabakoff%2C+B&rft.aulast=Nhamburo&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vanadate enhances phosphotyrosine protein levels in Nakano lens cells AN - 40765587; 0923993 AU - Gentleman, S AU - Reid, T W AU - Martensen, T M AU - Chader, G J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Vanadate+enhances+phosphotyrosine+protein+levels+in+Nakano+lens+cells&rft.au=Gentleman%2C+S%3BReid%2C+T+W%3BMartensen%2C+T+M%3BChader%2C+G+J&rft.aulast=Gentleman&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inducible form of testosterone 16 alpha -hydroxylase in mice: Purification, sexual dimorphism, and genetic variants AN - 40765404; 0929369 AU - Negishi, M AU - de Vore, K AU - Serabjit-Singh, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inducible+form+of+testosterone+16+alpha+-hydroxylase+in+mice%3A+Purification%2C+sexual+dimorphism%2C+and+genetic+variants&rft.au=Negishi%2C+M%3Bde+Vore%2C+K%3BSerabjit-Singh%2C+C&rft.aulast=Negishi&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a serum growth factor which stimulates hepatocyte proliferation AN - 40764428; 0913038 AU - Thorgeirsson, S S AU - Song, M-KH AU - Cone, J L AU - Roller, P P AU - Huggett, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+a+serum+growth+factor+which+stimulates+hepatocyte+proliferation&rft.au=Thorgeirsson%2C+S+S%3BSong%2C+M-KH%3BCone%2C+J+L%3BRoller%2C+P+P%3BHuggett%2C+A&rft.aulast=Thorgeirsson&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prolonged elevation of intracellular calcium by calcium ionophore, ionomycin, stimulates production of superoxide anion AN - 40764367; 0909389 AU - Seligmann, B AU - Gallin, JI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prolonged+elevation+of+intracellular+calcium+by+calcium+ionophore%2C+ionomycin%2C+stimulates+production+of+superoxide+anion&rft.au=Seligmann%2C+B%3BGallin%2C+JI&rft.aulast=Seligmann&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purification and characterization of E. coli protease which degrades oxidized glutamine synthetase AN - 40764228; 0926475 AU - Roseman, JE AU - Levine, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Purification+and+characterization+of+E.+coli+protease+which+degrades+oxidized+glutamine+synthetase&rft.au=Roseman%2C+JE%3BLevine%2C+R+L&rft.aulast=Roseman&rft.aufirst=JE&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temperature dependent conformational change in human plasma fibronectin demonstrated with monoclonal antibodies AN - 40764137; 0925879 AU - Brown, E J AU - Bohnsack, J F AU - O'Shea, J J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Temperature+dependent+conformational+change+in+human+plasma+fibronectin+demonstrated+with+monoclonal+antibodies&rft.au=Brown%2C+E+J%3BBohnsack%2C+J+F%3BO%27Shea%2C+J+J&rft.aulast=Brown&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationships between levels of lead exposure and excretion of lead and essential trace metals AN - 40763660; 0921030 AU - Victery, W AU - Miller, C R AU - Zhu, S AU - Goyer, R A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Relationships+between+levels+of+lead+exposure+and+excretion+of+lead+and+essential+trace+metals&rft.au=Victery%2C+W%3BMiller%2C+C+R%3BZhu%2C+S%3BGoyer%2C+R+A&rft.aulast=Victery&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interleukin 2 (IL-2) upregulates IL-2 receptor expression: Evidence that IL-2 augments IL-2 receptor mRNA AN - 40763041; 0916517 AU - Depper, J AU - Leonard, W AU - Drogula, C AU - Kroenke, M AU - Waldmann, T AU - Greene, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Interleukin+2+%28IL-2%29+upregulates+IL-2+receptor+expression%3A+Evidence+that+IL-2+augments+IL-2+receptor+mRNA&rft.au=Depper%2C+J%3BLeonard%2C+W%3BDrogula%2C+C%3BKroenke%2C+M%3BWaldmann%2C+T%3BGreene%2C+W&rft.aulast=Depper&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human T cell leukemia virus-I infection of T lymphocytes separated from human cord and peripheral blood by fractionation AN - 40762458; 0910027 AU - Macchi, B AU - Popovic, M AU - Allavena, P AU - Ortaldo, J R AU - Bonmassar, E AU - Gallo, R C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+T+cell+leukemia+virus-I+infection+of+T+lymphocytes+separated+from+human+cord+and+peripheral+blood+by+fractionation&rft.au=Macchi%2C+B%3BPopovic%2C+M%3BAllavena%2C+P%3BOrtaldo%2C+J+R%3BBonmassar%2C+E%3BGallo%2C+R+C&rft.aulast=Macchi&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of activation of ras oncogenes in experimental mammary cancer AN - 40762059; 0928930 AU - Sukumar, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanisms+of+activation+of+ras+oncogenes+in+experimental+mammary+cancer&rft.au=Sukumar%2C+S&rft.aulast=Sukumar&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary forms of rabbit and mouse microsomal flavin containing monooxygenase have unique primary amine N-hydroxylase activity AN - 40761508; 0929636 AU - Tynes, R E AU - Sabourin, P J AU - Hodgson, E AU - Philpot, R M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pulmonary+forms+of+rabbit+and+mouse+microsomal+flavin+containing+monooxygenase+have+unique+primary+amine+N-hydroxylase+activity&rft.au=Tynes%2C+R+E%3BSabourin%2C+P+J%3BHodgson%2C+E%3BPhilpot%2C+R+M&rft.aulast=Tynes&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cis and trans regulation of the cloned alpha sub(2) type I collagen promoter AN - 40759705; 0919381 AU - Schmidt, A AU - de Crombrugghe, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cis+and+trans+regulation+of+the+cloned+alpha+sub%282%29+type+I+collagen+promoter&rft.au=Schmidt%2C+A%3Bde+Crombrugghe%2C+B&rft.aulast=Schmidt&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional control of the delta opiate receptor by the inhibitory guanine nucleotide binding protein (Ni) AN - 40759151; 0914246 AU - Milligan, G AU - Simonds, W F AU - Tocque, B AU - Klee, WA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Functional+control+of+the+delta+opiate+receptor+by+the+inhibitory+guanine+nucleotide+binding+protein+%28Ni%29&rft.au=Milligan%2C+G%3BSimonds%2C+W+F%3BTocque%2C+B%3BKlee%2C+WA&rft.aulast=Milligan&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For ordering information contact the Biochemical Society, 7 Warwick Court, London WC1R 5DP, UK N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in keratin gene expression during hormone induced differentiation AN - 40735937; 0900811 AU - Roop AU - Kronenberg AU - Clark, J H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40735937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Changes+in+keratin+gene+expression+during+hormone+induced+differentiation&rft.au=Roop%3BKronenberg%3BClark%2C+J+H&rft.aulast=Roop&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information concerning UCLA Symposia publication, contact Allan R. Liss, Inc., 150 Fifth Avenue, New York, NY 10011, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of perinatal exposure to ethylenethiourea on the thyroid of rats and mice exposed as adults AN - 40729368; 0851817 AU - Chhabra, R S AU - Wilkinson, GE AU - Carlton, B D AU - Kurtz, P J AU - Grumbein, S L AU - Toft, J D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40729368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+perinatal+exposure+to+ethylenethiourea+on+the+thyroid+of+rats+and+mice+exposed+as+adults&rft.au=Chhabra%2C+R+S%3BWilkinson%2C+GE%3BCarlton%2C+B+D%3BKurtz%2C+P+J%3BGrumbein%2C+S+L%3BToft%2C+J+D&rft.aulast=Chhabra&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For proceedings availability contact Society of Toxicology, c/o Joseph R. Wasdovich, 475 Wolf Ledges Parkway, Akron, OH 44311, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity testing program of chemicals in priority hazardous waste sites at the National Toxicology Program AN - 40729191; 0852227 AU - Yang, RSH AU - Rauckman, E J AU - Kluwe, WM Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40729191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Toxicity+testing+program+of+chemicals+in+priority+hazardous+waste+sites+at+the+National+Toxicology+Program&rft.au=Yang%2C+RSH%3BRauckman%2C+E+J%3BKluwe%2C+WM&rft.aulast=Yang&rft.aufirst=RSH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For proceedings availability contact Society of Toxicology, c/o Joseph R. Wasdovich, 475 Wolf Ledges Parkway, Akron, OH 44311, USA, Poster Paper N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stimulatory role of purified IL-1 on human NK cells AN - 40725256; 0854524 AU - Benczur, M AU - Matsushima, K AU - Oppenheim, J J AU - Herberman, R B AU - Ortaldo, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40725256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stimulatory+role+of+purified+IL-1+on+human+NK+cells&rft.au=Benczur%2C+M%3BMatsushima%2C+K%3BOppenheim%2C+J+J%3BHerberman%2C+R+B%3BOrtaldo%2C+J+R&rft.aulast=Benczur&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For proceedings availability contact Reticuloendothelial Society, c/o Dr. Sherwood M. Richard, Medical College of Georgia, Augusta, GA 30912, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Issues in the statistical analysis of spontaneous abortions (miscarriages) AN - 40715804; 0855009 AU - Gladen, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 6500:MATHEMATICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Issues+in+the+statistical+analysis+of+spontaneous+abortions+%28miscarriages%29&rft.au=Gladen%2C+B&rft.aulast=Gladen&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For proceedings availability contact Dr. Rita Zemach, 519 N. Harrison Rd., East Lansing, MI 48823, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Excess incidence of pneumocystis pneumonia (PCP) in lymphoma patients (pts) receiving combination chemotherapy AN - 40712523; 0812231 AU - Browne, M AU - Wesley, R AU - Cotton, D AU - Fisher, R AU - Pizzo, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL KW - U 1500:BIOCHEMISTRY KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40712523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Excess+incidence+of+pneumocystis+pneumonia+%28PCP%29+in+lymphoma+patients+%28pts%29+receiving+combination+chemotherapy&rft.au=Browne%2C+M%3BWesley%2C+R%3BCotton%2C+D%3BFisher%2C+R%3BPizzo%2C+P&rft.aulast=Browne&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Program and Abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy", 1984, ASM Publications Office, 1913 I Street, NW, Washington, DC 20006, USA, ISBN 0-914826-67-0; ISSN 0733-6373; Price: $10.00 Abstract No. 686 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Practical aspects of analytical chemistry support for toxicity studies AN - 40708167; 0810051 AU - Jameson, C W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 8000:PHYSICS AND ASTRONOMY KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40708167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Practical+aspects+of+analytical+chemistry+support+for+toxicity+studies&rft.au=Jameson%2C+C+W&rft.aulast=Jameson&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available: Dr. Ed Brame, E.I. DuPont Experimental Station, E269, Wilmington, DE 19898, USA, Price: $10.00 Abstract No. 466 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human cell sensitivity to natural killer cell during carcinogenesis AN - 40681579; 0704883 AU - DiPaolo, JA AU - Doniger, J AU - Popescu, N C AU - Heinbaugh, JA AU - Evans, CH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40681579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+cell+sensitivity+to+natural+killer+cell+during+carcinogenesis&rft.au=DiPaolo%2C+JA%3BDoniger%2C+J%3BPopescu%2C+N+C%3BHeinbaugh%2C+JA%3BEvans%2C+CH&rft.aulast=DiPaolo&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fifth Annual Meeting of the American Association for Cancer Research", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 534 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time course and dose-response for induction of two cytochrome P-450 isozymes and translation of their mRNAs in rat liver after administration of 3,4,5,3',4',5'-hexachlorobiphenyl (HCB) AN - 40677551; 0742943 AU - Hardwick, J P AU - Linko, P AU - Goldstein, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40677551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Time+course+and+dose-response+for+induction+of+two+cytochrome+P-450+isozymes+and+translation+of+their+mRNAs+in+rat+liver+after+administration+of+3%2C4%2C5%2C3%27%2C4%27%2C5%27-hexachlorobiphenyl+%28HCB%29&rft.au=Hardwick%2C+J+P%3BLinko%2C+P%3BGoldstein%2C+JA&rft.aulast=Hardwick&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1984, Abstracts booklet available: Special Publications Dep., FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, 2 vols.; Price: $25.00 Paper No. 343 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Instability of 7,12-dimethylbenz(a)anthracene-modified DNA AN - 40674914; 0702871 AU - Moschel, R C AU - Pigott, MA AU - Dipple, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40674914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Instability+of+7%2C12-dimethylbenz%28a%29anthracene-modified+DNA&rft.au=Moschel%2C+R+C%3BPigott%2C+MA%3BDipple%2C+A&rft.aulast=Moschel&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fifth Annual Meeting of the American Association for Cancer Research", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 355 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early changes induced in rat liver cells by methapyrilene AN - 40674728; 0702329 AU - Iype, P T AU - Bucana, C D AU - Kelley, S P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40674728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Early+changes+induced+in+rat+liver+cells+by+methapyrilene&rft.au=Iype%2C+P+T%3BBucana%2C+C+D%3BKelley%2C+S+P&rft.aulast=Iype&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fifth Annual Meeting of the American Association for Cancer Research", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 291 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Separation of polychlorinated biphenyls by high performance liquid chromatography AN - 40668725; 0732522 AU - Issaq, HJ AU - Klose, J AU - Muschik, G M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40668725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Separation+of+polychlorinated+biphenyls+by+high+performance+liquid+chromatography&rft.au=Issaq%2C+HJ%3BKlose%2C+J%3BMuschik%2C+G+M&rft.aulast=Issaq&rft.aufirst=HJ&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Proceedings in: "Advances in Chromatography - 1984" edited by A. Zlatkis, Sep. 15, 1984, Dr. A. Zlatkis, Chromatography Division, Chemistry Department, University of Houston, Houston, TX 77004, USA, Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serial nuclear magnetic resonance (NMR) scans of inflammatory carcinoma of the breast AN - 40666097; 0709089 AU - Weiss, SH AU - Ross, R J AU - Lippman, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40666097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Serial+nuclear+magnetic+resonance+%28NMR%29+scans+of+inflammatory+carcinoma+of+the+breast&rft.au=Weiss%2C+SH%3BRoss%2C+R+J%3BLippman%2C+M&rft.aulast=Weiss&rft.aufirst=SH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings American Society of Clinical Oncology", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Abstract No. C-53 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of lymph node biopsy in evaluation of cutaneous T-cell lymphoma (CTCL) AN - 40665560; 0706388 AU - Sausville, E AU - Matthews, M AU - Gazdar, A AU - Worsham, G F AU - Makuch, R AU - Bunn, PA Jr Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40665560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+lymph+node+biopsy+in+evaluation+of+cutaneous+T-cell+lymphoma+%28CTCL%29&rft.au=Sausville%2C+E%3BMatthews%2C+M%3BGazdar%2C+A%3BWorsham%2C+G+F%3BMakuch%2C+R%3BBunn%2C+PA+Jr&rft.aulast=Sausville&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fifth Annual Meeting of the American Association for Cancer Research", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 766 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of tumor cell cytostasis by polypeptides isolated from human tumor cells AN - 40664484; 0701304 AU - Funkhouser, W K AU - Neckers, L M AU - Ames, R S AU - Carney, D N AU - Trepel, J B AU - Roth, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40664484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+tumor+cell+cytostasis+by+polypeptides+isolated+from+human+tumor+cells&rft.au=Funkhouser%2C+W+K%3BNeckers%2C+L+M%3BAmes%2C+R+S%3BCarney%2C+D+N%3BTrepel%2C+J+B%3BRoth%2C+JA&rft.aulast=Funkhouser&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fifth Annual Meeting of the American Association for Cancer Research", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 134 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA lesions induced by aziridinylbenzoquinone (AZQ, NSC 182986) in human glioblastoma cell lines AN - 40663904; 0708968 AU - Sariban, E AU - D'Incalci, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40663904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=DNA+lesions+induced+by+aziridinylbenzoquinone+%28AZQ%2C+NSC+182986%29+in+human+glioblastoma+cell+lines&rft.au=Sariban%2C+E%3BD%27Incalci%2C+M&rft.aulast=Sariban&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fifth Annual Meeting of the American Association for Cancer Research", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 1144 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prediction of toxicity (T) in phase I (PI) anticancer drug trials by the National Cancer Institute (NCI) preclinical toxicology protocol (NPTP) AN - 40663861; 0705977 AU - Marsoni, S AU - Hurson, S AU - Simon, R AU - Grieshaber, C AU - Hoth, D AU - Shoemaker, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40663861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prediction+of+toxicity+%28T%29+in+phase+I+%28PI%29+anticancer+drug+trials+by+the+National+Cancer+Institute+%28NCI%29+preclinical+toxicology+protocol+%28NPTP%29&rft.au=Marsoni%2C+S%3BHurson%2C+S%3BSimon%2C+R%3BGrieshaber%2C+C%3BHoth%2C+D%3BShoemaker%2C+D&rft.aulast=Marsoni&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fifth Annual Meeting of the American Association for Cancer Research", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 664 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cardiac events (CE) in patients (PTS) treated with mitoxantrone (M) in phase II trials (Ph II) sponsored by the National Cancer Institute (NCI) AN - 40663825; 0705975 AU - Foster, B AU - Lev, L AU - Bergmann, C AU - Claggett-Carr, C AU - Marsoni, S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40663825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cardiac+events+%28CE%29+in+patients+%28PTS%29+treated+with+mitoxantrone+%28M%29+in+phase+II+trials+%28Ph+II%29+sponsored+by+the+National+Cancer+Institute+%28NCI%29&rft.au=Foster%2C+B%3BLev%2C+L%3BBergmann%2C+C%3BClaggett-Carr%2C+C%3BMarsoni%2C+S&rft.aulast=Foster&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fifth Annual Meeting of the American Association for Cancer Research", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 663 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chrysotile asbestos directly suppresses the activity of natural killer cells AN - 40663491; 0705960 AU - Robinson, B AU - Crystal, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40663491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chrysotile+asbestos+directly+suppresses+the+activity+of+natural+killer+cells&rft.au=Robinson%2C+B%3BCrystal%2C+R&rft.aulast=Robinson&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "American Review of Respiratory Disease", Apr. 1984, American Lung Association, 1740 Broadway, New York, NY 10019, USA, ISSN 0003-0805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuropeptide precursor of anxiogenic putative ligand of benzodiazepine recognition site AN - 40659793; 0690652 AU - Ferrari, M AU - Corda, M G AU - Guidotti, A AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neuropeptide+precursor+of+anxiogenic+putative+ligand+of+benzodiazepine+recognition+site&rft.au=Ferrari%2C+M%3BCorda%2C+M+G%3BGuidotti%2C+A%3BCosta%2C+E&rft.aulast=Ferrari&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 4723 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduced expression of glycolipid antigens in small cell lung cancer variant cell lines (SCLC-v) as detected by a panel of monoclonal antibodies (MoAb) AN - 40659297; 0709159 AU - Mulshine, J AU - Cuttitta, F AU - Rosen, S AU - Carney, D AU - Minna, J AU - Gazdar, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Reduced+expression+of+glycolipid+antigens+in+small+cell+lung+cancer+variant+cell+lines+%28SCLC-v%29+as+detected+by+a+panel+of+monoclonal+antibodies+%28MoAb%29&rft.au=Mulshine%2C+J%3BCuttitta%2C+F%3BRosen%2C+S%3BCarney%2C+D%3BMinna%2C+J%3BGazdar%2C+A&rft.aulast=Mulshine&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings American Society of Clinical Oncology", Mar. 1984, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Abstract No. C-64 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of human alpha 1-antitrypsin gene directed E. coli produced alpha 1-antitrypsin AN - 40657415; 0708075 AU - Straus, S AU - Fells, G AU - Dalgleish, R AU - Courtney, M AU - Tessiere, L-H AU - Roitsch, C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40657415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Characterization+of+human+alpha+1-antitrypsin+gene+directed+E.+coli+produced+alpha+1-antitrypsin&rft.au=Straus%2C+S%3BFells%2C+G%3BDalgleish%2C+R%3BCourtney%2C+M%3BTessiere%2C+L-H%3BRoitsch%2C+C&rft.aulast=Straus&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "American Review of Respiratory Disease", Apr. 1984, American Lung Association, 1740 Broadway, New York, NY 10019, USA, ISSN 0003-0805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory response to intrapleural injection of complement activators and histamine liberators in the rat AN - 40655682; 0679499 AU - Lo, T N AU - WoldeMussie, E AU - Beaven, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Inflammatory+response+to+intrapleural+injection+of+complement+activators+and+histamine+liberators+in+the+rat&rft.au=Lo%2C+T+N%3BWoldeMussie%2C+E%3BBeaven%2C+MA&rft.aulast=Lo&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 589 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences between human monocytes and lymphocytes at the level of interferon gene expression AN - 40654830; 0679143 AU - Stevenson, H AU - Dekaban, G AU - Benyajati, C AU - Miller, P AU - Pearson, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differences+between+human+monocytes+and+lymphocytes+at+the+level+of+interferon+gene+expression&rft.au=Stevenson%2C+H%3BDekaban%2C+G%3BBenyajati%2C+C%3BMiller%2C+P%3BPearson%2C+M&rft.aulast=Stevenson&rft.aufirst=H&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 510 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is the human lung a site of immunoglobulin synthesis? AN - 40653944; 0701100 AU - Hance, A J AU - Zimmerman, R AU - Crystal, R G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40653944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Is+the+human+lung+a+site+of+immunoglobulin+synthesis%3F&rft.au=Hance%2C+A+J%3BZimmerman%2C+R%3BCrystal%2C+R+G&rft.aulast=Hance&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "American Review of Respiratory Disease", Apr. 1984, American Lung Association, 1740 Broadway, New York, NY 10019, USA, ISSN 0003-0805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the human T-cell leukemia-lymphoma virus as a possible etiology of sarcoidosis AN - 40651705; 0703056 AU - Pinkston, P AU - Sarin, P AU - Saxinger, W C AU - Hahn, B AU - Gallo, R AU - Crystal, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40651705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evaluation+of+the+human+T-cell+leukemia-lymphoma+virus+as+a+possible+etiology+of+sarcoidosis&rft.au=Pinkston%2C+P%3BSarin%2C+P%3BSaxinger%2C+W+C%3BHahn%2C+B%3BGallo%2C+R%3BCrystal%2C+R&rft.aulast=Pinkston&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "American Review of Respiratory Disease", Apr. 1984, American Lung Association, 1740 Broadway, New York, NY 10019, USA, ISSN 0003-0805 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of chronic ethionine feeding on the levels of S-adenosylmethionine, S-adenosylethionine, and DNA 5-methyldeoxycytidine in rat tissues AN - 40648480; 0682258 AU - Shivapurkar, N AU - Wilson, MJ AU - Poirier, LA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40648480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+chronic+ethionine+feeding+on+the+levels+of+S-adenosylmethionine%2C+S-adenosylethionine%2C+and+DNA+5-methyldeoxycytidine+in+rat+tissues&rft.au=Shivapurkar%2C+N%3BWilson%2C+MJ%3BPoirier%2C+LA&rft.aulast=Shivapurkar&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in Federation Proceedings (Mar. 1 and Mar. 5), 1984, FASEB, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstract No. 1790 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monoclonal antibodies to smooth muscle myosin heavy chain subfragments S-1, S-2, and light meromyosin AN - 40645289; 0669860 AU - Schneider, MD AU - Sellers, J R AU - Preston, YA AU - Adelstein, R S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 8000:PHYSICS AND ASTRONOMY KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40645289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Monoclonal+antibodies+to+smooth+muscle+myosin+heavy+chain+subfragments+S-1%2C+S-2%2C+and+light+meromyosin&rft.au=Schneider%2C+MD%3BSellers%2C+J+R%3BPreston%2C+YA%3BAdelstein%2C+R+S&rft.aulast=Schneider&rft.aufirst=MD&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Biophysical Journal", Feb. 1984, Rockefeller University Press, P.O. Box 5108, Church St. Station, New York, NY 10249, USA, Price: $18.50 Paper No. W-Pos151 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polycation induced fusion of acidic lipid containing vesicles: pH and charge dependence AN - 40635446; 0662938 AU - Walter, A AU - Margolis, D AU - Blumenthal, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 8000:PHYSICS AND ASTRONOMY KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40635446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Polycation+induced+fusion+of+acidic+lipid+containing+vesicles%3A+pH+and+charge+dependence&rft.au=Walter%2C+A%3BMargolis%2C+D%3BBlumenthal%2C+R&rft.aulast=Walter&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Biophysical Journal", Feb. 1984, Rockefeller University Press, P.O. Box 5108, Church St. Station, New York, NY 10249, USA, Price: $18.50 Paper No. M-Pos59 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Different noradrenergic responses to norepinephrine reuptake inhibition in middle-aged vs young volunteers AN - 40634200; 0642116 AU - Lesieur, P AU - Ross, R J AU - Rudorfer, M V AU - Linnoila, M AU - Potter, W Z Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7500:PHARMACOLOGY KW - U 3500:CLINICAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40634200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Different+noradrenergic+responses+to+norepinephrine+reuptake+inhibition+in+middle-aged+vs+young+volunteers&rft.au=Lesieur%2C+P%3BRoss%2C+R+J%3BRudorfer%2C+M+V%3BLinnoila%2C+M%3BPotter%2C+W+Z&rft.aulast=Lesieur&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Pharmacology and Therapeutics", Feb. 1984, American Society for Clinical Pharmacology and Therapeutics, 1718 Gallagher Road, Norristown, PA 19401, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective inter-residue contact energies from protein crystal structures AN - 40630026; 0663743 AU - Miyazawa, S AU - Jernigan, R L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 8000:PHYSICS AND ASTRONOMY KW - U 1500:BIOCHEMISTRY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40630026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effective+inter-residue+contact+energies+from+protein+crystal+structures&rft.au=Miyazawa%2C+S%3BJernigan%2C+R+L&rft.aulast=Miyazawa&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Biophysical Journal", Feb. 1984, Rockefeller University Press, P.O. Box 5108, Church St. Station, New York, NY 10249, USA, Price: $18.50 Paper No. M-Pos223 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preservation of multilamellar lipid vesicles (liposomes) for ultrastructural studies AN - 40598750; 0566239 AU - Bucana, C AU - Hoyer, L C AU - Plentovich, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 8000:PHYSICS AND ASTRONOMY UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40598750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preservation+of+multilamellar+lipid+vesicles+%28liposomes%29+for+ultrastructural+studies&rft.au=Bucana%2C+C%3BHoyer%2C+L+C%3BPlentovich%2C+D&rft.aulast=Bucana&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Proceedings in: "Scanning Electron Microscopy/1983/I-III", 1983, Scanning Electron Microscopy, Inc., P.O. Box 66507, AMF O'Hare (Chicago), IL 60666 USA, ISSN 0586-5581. Proceedings consists of 3 issues N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High metabolic activity in the septal triangular nucleus in rat models of thirst AN - 40597161; 0592433 AU - Kadekaro, M AU - Gross, P M AU - Sokoloff, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40597161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=High+metabolic+activity+in+the+septal+triangular+nucleus+in+rat+models+of+thirst&rft.au=Kadekaro%2C+M%3BGross%2C+P+M%3BSokoloff%2C+L&rft.aulast=Kadekaro&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "The Physiologist", Aug 1983, American Physiological Society, 9650 Rockville Pike, Bethesda, MD 20814, USA, ISSN 0031-9376 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development and use of a cell surface ELISA assay for the purification of swine Ia antigens AN - 40573697; 0479976 AU - Lunney, J K AU - Osborne, BA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40573697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Development+and+use+of+a+cell+surface+ELISA+assay+for+the+purification+of+swine+Ia+antigens&rft.au=Lunney%2C+J+K%3BOsborne%2C+BA&rft.aulast=Lunney&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decreased cyclophosphamide (CP) induced myelosuppression (MS) in mice fed a high protein diet AN - 40571359; 0498425 AU - Ioannou, IA AU - Demetrakopoulos, GE AU - Rosenthal, A AU - Pizzo, P A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40571359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Decreased+cyclophosphamide+%28CP%29+induced+myelosuppression+%28MS%29+in+mice+fed+a+high+protein+diet&rft.au=Ioannou%2C+IA%3BDemetrakopoulos%2C+GE%3BRosenthal%2C+A%3BPizzo%2C+P+A&rft.aulast=Ioannou&rft.aufirst=IA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings American Society of Clinical Oncology Nineteenth Annual Meeting", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Abstract No. C-368 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunologic function of Hodgkin's disease cells: accessory cell function for mitogen-induced, human T cell proliferative responses AN - 40570599; 0479863 AU - Fisher, R I AU - Bostick-Bruton, F AU - Diehl, V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40570599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunologic+function+of+Hodgkin%27s+disease+cells%3A+accessory+cell+function+for+mitogen-induced%2C+human+T+cell+proliferative+responses&rft.au=Fisher%2C+R+I%3BBostick-Bruton%2C+F%3BDiehl%2C+V&rft.aulast=Fisher&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vitro phase II trials of standard and escalated dose chemotherapy using cell lines of human non-small cell lung cancer AN - 40569850; 0497269 AU - Brower, M AU - Carney, D AU - Dainer, P AU - Minna, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40569850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vitro+phase+II+trials+of+standard+and+escalated+dose+chemotherapy+using+cell+lines+of+human+non-small+cell+lung+cancer&rft.au=Brower%2C+M%3BCarney%2C+D%3BDainer%2C+P%3BMinna%2C+J&rft.aulast=Brower&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings American Society of Clinical Oncology Nineteenth Annual Meeting", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Abstract No. C-135 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Murine monoclonal antibodies which selectively bind non-small cell lung cancer (non-SCLC) AN - 40569734; 0497015 AU - Mulshine, J AU - Cuttitta, F AU - Little, C AU - Fargion, S AU - Fedorko, J AU - Bibro, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40569734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Murine+monoclonal+antibodies+which+selectively+bind+non-small+cell+lung+cancer+%28non-SCLC%29&rft.au=Mulshine%2C+J%3BCuttitta%2C+F%3BLittle%2C+C%3BFargion%2C+S%3BFedorko%2C+J%3BBibro%2C+M&rft.aulast=Mulshine&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings American Society of Clinical Oncology Nineteenth Annual Meeting", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Abstract No. C-57 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adoptively transferred, in vitro sensitized, Ly 2+ cells mediate accelerated rejection of murine skin grafts AN - 40561576; 0473885 AU - McCullough, C S AU - Sugarbaker, PH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40561576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Adoptively+transferred%2C+in+vitro+sensitized%2C+Ly+2%2B+cells+mediate+accelerated+rejection+of+murine+skin+grafts&rft.au=McCullough%2C+C+S%3BSugarbaker%2C+PH&rft.aulast=McCullough&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Randomized trial of chemotherapy versus chemotherapy plus radiotherapy in limited stage small cell lung cancer (SCLC) AN - 40560304; 0500882 AU - Bunn, P AU - Cohen, M AU - Lichter, A AU - Makuch, R AU - Ihde, D AU - Carney, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Randomized+trial+of+chemotherapy+versus+chemotherapy+plus+radiotherapy+in+limited+stage+small+cell+lung+cancer+%28SCLC%29&rft.au=Bunn%2C+P%3BCohen%2C+M%3BLichter%2C+A%3BMakuch%2C+R%3BIhde%2C+D%3BCarney%2C+D&rft.aulast=Bunn&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings American Society of Clinical Oncology Nineteenth Annual Meeting", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Abstract No. C-780 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue similarity within a species in the form of cytochrome P-450 blocked by a monoclonal antibody AN - 40559707; 0473392 AU - Sasame, HA AU - Gillette, J R AU - Park, S S AU - Gelboin, H V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tissue+similarity+within+a+species+in+the+form+of+cytochrome+P-450+blocked+by+a+monoclonal+antibody&rft.au=Sasame%2C+HA%3BGillette%2C+J+R%3BPark%2C+S+S%3BGelboin%2C+H+V&rft.aulast=Sasame&rft.aufirst=HA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histamine metabolism by rat and guinea pig microvascular endothelial cells AN - 40559587; 0473346 AU - Robinson-White, A AU - Beaven, MA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Histamine+metabolism+by+rat+and+guinea+pig+microvascular+endothelial+cells&rft.au=Robinson-White%2C+A%3BBeaven%2C+MA&rft.aulast=Robinson-White&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - KCl cotransport during epithelial cell volume regulation AN - 40559191; 0474761 AU - Larson, M AU - Spring, K R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=KCl+cotransport+during+epithelial+cell+volume+regulation&rft.au=Larson%2C+M%3BSpring%2C+K+R&rft.aulast=Larson&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase II efficacy trials of recombinant leukocyte a interferon in previously treated non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and mycosis fungoides AN - 40559008; 0501152 AU - Sherwin, S AU - Longo, D AU - Bunn, P AU - Fein, S AU - Abrams, P AU - Ochs, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Phase+II+efficacy+trials+of+recombinant+leukocyte+a+interferon+in+previously+treated+non-Hodgkin%27s+lymphoma%2C+chronic+lymphocytic+leukemia%2C+and+mycosis+fungoides&rft.au=Sherwin%2C+S%3BLongo%2C+D%3BBunn%2C+P%3BFein%2C+S%3BAbrams%2C+P%3BOchs%2C+J&rft.aulast=Sherwin&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings American Society of Clinical Oncology Nineteenth Annual Meeting", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Abstract No. C-823 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Late intensive combined modality therapy (LIPX) with autologous bone marrow (ABM) infusion in extensive stage small cell lung cancer (SCLC) AN - 40558376; 0500866 AU - Ihde, D C AU - Lichter, A S AU - Deisseroth, AB AU - Bunn, P A AU - Carney, D N AU - Cohen, M H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Late+intensive+combined+modality+therapy+%28LIPX%29+with+autologous+bone+marrow+%28ABM%29+infusion+in+extensive+stage+small+cell+lung+cancer+%28SCLC%29&rft.au=Ihde%2C+D+C%3BLichter%2C+A+S%3BDeisseroth%2C+AB%3BBunn%2C+P+A%3BCarney%2C+D+N%3BCohen%2C+M+H&rft.aulast=Ihde&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings American Society of Clinical Oncology Nineteenth Annual Meeting", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Abstract No. C-774 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In vivo metabolism of murine interleukin 2 AN - 40557930; 0476258 AU - Donohue, J H AU - Rosenberg, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=In+vivo+metabolism+of+murine+interleukin+2&rft.au=Donohue%2C+J+H%3BRosenberg%2C+SA&rft.aulast=Donohue&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppression of immunoglobulin synthesis by lymphocytes reactive with Leu-2a and HNK-1 in patients with Crohn's disease AN - 40557873; 0481950 AU - James, S P AU - Neckers, L M AU - Graeff, A S AU - Cossman, J AU - Balch, C M AU - Strober, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Suppression+of+immunoglobulin+synthesis+by+lymphocytes+reactive+with+Leu-2a+and+HNK-1+in+patients+with+Crohn%27s+disease&rft.au=James%2C+S+P%3BNeckers%2C+L+M%3BGraeff%2C+A+S%3BCossman%2C+J%3BBalch%2C+C+M%3BStrober%2C+W&rft.aulast=James&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dual role for glutathione transferase in detoxification of bromobenzene-3,4-oxide AN - 40557651; 0477606 AU - Monks, T J AU - Lau, S S AU - Gillette, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dual+role+for+glutathione+transferase+in+detoxification+of+bromobenzene-3%2C4-oxide&rft.au=Monks%2C+T+J%3BLau%2C+S+S%3BGillette%2C+J+R&rft.aulast=Monks&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intra- and extracellular distribution of surfactant phospholipids in lungs of rabbits AN - 40556272; 0480600 AU - Dethloff, LA AU - Hook, GER Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intra-+and+extracellular+distribution+of+surfactant+phospholipids+in+lungs+of+rabbits&rft.au=Dethloff%2C+LA%3BHook%2C+GER&rft.aulast=Dethloff&rft.aufirst=LA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethyl choline mustard aziridinium ion, a selective cholinergic neurotoxin, produces long-term learning and memory impairments AN - 40555444; 0470126 AU - Walsh, T J AU - Tilson, HA AU - Fisher, A AU - Hanin, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ethyl+choline+mustard+aziridinium+ion%2C+a+selective+cholinergic+neurotoxin%2C+produces+long-term+learning+and+memory+impairments&rft.au=Walsh%2C+T+J%3BTilson%2C+HA%3BFisher%2C+A%3BHanin%2C+I&rft.aulast=Walsh&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ionic dependence of epithelial cell volume regulation AN - 40554722; 0474759 AU - Fisher, R S AU - Spring, K R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Ionic+dependence+of+epithelial+cell+volume+regulation&rft.au=Fisher%2C+R+S%3BSpring%2C+K+R&rft.aulast=Fisher&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary macrophage accumulation at sites of asbestos deposition and the earliest anatomic lesion of asbestosis AN - 40554448; 0470657 AU - Warheit, D B AU - Chang, L Y AU - Hill, L H AU - Crapo, J D AU - Brody, A R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pulmonary+macrophage+accumulation+at+sites+of+asbestos+deposition+and+the+earliest+anatomic+lesion+of+asbestosis&rft.au=Warheit%2C+D+B%3BChang%2C+L+Y%3BHill%2C+L+H%3BCrapo%2C+J+D%3BBrody%2C+A+R&rft.aulast=Warheit&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of plasmacytoid differentiation in undifferentiated B-cell lymphoma (UL) cell lines (CL) by phorbolester (TPA) AN - 40551457; 0456666 AU - Benjamin, D AU - Magrath, I T AU - Triche, T J AU - Korsmeyer, S J AU - Schroff, R W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40551457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Induction+of+plasmacytoid+differentiation+in+undifferentiated+B-cell+lymphoma+%28UL%29+cell+lines+%28CL%29+by+phorbolester+%28TPA%29&rft.au=Benjamin%2C+D%3BMagrath%2C+I+T%3BTriche%2C+T+J%3BKorsmeyer%2C+S+J%3BSchroff%2C+R+W&rft.aulast=Benjamin&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fourth Annual Meeting of the American Association for Cancer Research", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 819 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lysis of fresh atuologous human solid tumor cells by lymphokine activated killer cells (LAK): characterization of the cell type and responsible lymphokine AN - 40550694; 0456838 AU - Grimm, E A AU - Wilson, D J AU - Rosenberg, SA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40550694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Lysis+of+fresh+atuologous+human+solid+tumor+cells+by+lymphokine+activated+killer+cells+%28LAK%29%3A+characterization+of+the+cell+type+and+responsible+lymphokine&rft.au=Grimm%2C+E+A%3BWilson%2C+D+J%3BRosenberg%2C+SA&rft.aulast=Grimm&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fourth Annual Meeting of the American Association for Cancer Research", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 835 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytotoxicity, mutation and neoplastic transformation induced by single and split doses of N-methyl-N'-nitro-N-nitrosoguanidine in the BALB/3T3-C1A31-1-1 cell line AN - 40550641; 0467254 AU - Bignami, M AU - Dogliotti, E AU - Benigni, R AU - Kaighn, ME AU - Saffiotti, U Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40550641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cytotoxicity%2C+mutation+and+neoplastic+transformation+induced+by+single+and+split+doses+of+N-methyl-N%27-nitro-N-nitrosoguanidine+in+the+BALB%2F3T3-C1A31-1-1+cell+line&rft.au=Bignami%2C+M%3BDogliotti%2C+E%3BBenigni%2C+R%3BKaighn%2C+ME%3BSaffiotti%2C+U&rft.aulast=Bignami&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of fluoresceinated complement coated bacteria (FBC) and EAC sub(M) for identification of complement receptors on lymphoid cell lines: differences in binding characteristics between cell lines of normal and malignant origin AN - 40550198; 0456460 AU - Benjamin, D AU - Magrath, I T AU - Freeman, C B AU - Weiss, R B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40550198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+fluoresceinated+complement+coated+bacteria+%28FBC%29+and+EAC+sub%28M%29+for+identification+of+complement+receptors+on+lymphoid+cell+lines%3A+differences+in+binding+characteristics+between+cell+lines+of+normal+and+malignant+origin&rft.au=Benjamin%2C+D%3BMagrath%2C+I+T%3BFreeman%2C+C+B%3BWeiss%2C+R+B&rft.aulast=Benjamin&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fourth Annual Meeting of the American Association for Cancer Research", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 786 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purification and characterization of an endogenous effector for benzodiazepine recognition sites located in brain AN - 40550101; 0460830 AU - Guidotti, A AU - Corda, M G AU - Forchetti, M C AU - Konkel, D AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40550101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Purification+and+characterization+of+an+endogenous+effector+for+benzodiazepine+recognition+sites+located+in+brain&rft.au=Guidotti%2C+A%3BCorda%2C+M+G%3BForchetti%2C+M+C%3BKonkel%2C+D%3BCosta%2C+E&rft.aulast=Guidotti&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hypotensive action of 4-(5,6-dimethyl-2-benzofuranyl) piperidine HCl in SHR and normotensive Wistar-Kyoto rats AN - 40549387; 0467820 AU - Kulakowski, E C AU - Hurst, J H AU - Lovenberg, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40549387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hypotensive+action+of+4-%285%2C6-dimethyl-2-benzofuranyl%29+piperidine+HCl+in+SHR+and+normotensive+Wistar-Kyoto+rats&rft.au=Kulakowski%2C+E+C%3BHurst%2C+J+H%3BLovenberg%2C+W&rft.aulast=Kulakowski&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral and biochemical actions of GABAergic drugs on the septal-hippocampal system AN - 40546680; 0464115 AU - Blaker, W D AU - Cheney, D L AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40546680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Behavioral+and+biochemical+actions+of+GABAergic+drugs+on+the+septal-hippocampal+system&rft.au=Blaker%2C+W+D%3BCheney%2C+D+L%3BCosta%2C+E&rft.aulast=Blaker&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Federation Proceedings", Mar. 1983, FASEB Special Publications Office, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts in a 3 vol. set. Price: $40.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in lipid composition and structural order between anthracycline sensitive and resistant P388 murine leukemia cells AN - 40542871; 0460870 AU - Glaubiger, D AU - Ramu, A AU - Weintraub, H AU - Magrath, I AU - Brereton, H AU - Joshi, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40542871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differences+in+lipid+composition+and+structural+order+between+anthracycline+sensitive+and+resistant+P388+murine+leukemia+cells&rft.au=Glaubiger%2C+D%3BRamu%2C+A%3BWeintraub%2C+H%3BMagrath%2C+I%3BBrereton%2C+H%3BJoshi%2C+A&rft.aulast=Glaubiger&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fourth Annual Meeting of the American Association for Cancer Research", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 1124 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of prostaglandin endoperoxide synthetase (PES) inhibitors on the formation of benzo(a)pyrene (BP)-induced pulmonary adenomas and on the binding of BP metabolites to DNA AN - 40541815; 0451189 AU - Anderson, M W AU - Sivarajah, K AU - Adriaenssens, P I AU - Boorman, G A AU - Eling, TE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40541815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+prostaglandin+endoperoxide+synthetase+%28PES%29+inhibitors+on+the+formation+of+benzo%28a%29pyrene+%28BP%29-induced+pulmonary+adenomas+and+on+the+binding+of+BP+metabolites+to+DNA&rft.au=Anderson%2C+M+W%3BSivarajah%2C+K%3BAdriaenssens%2C+P+I%3BBoorman%2C+G+A%3BEling%2C+TE&rft.aulast=Anderson&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fourth Annual Meeting of the American Association for Cancer Research", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 340 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Energy metabolism of cultured human normal lymphocytes and American Burkitt lymphoma cells AN - 40541646; 0448746 AU - Sariban-Sohraby, S AU - Balaban, R S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40541646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Energy+metabolism+of+cultured+human+normal+lymphocytes+and+American+Burkitt+lymphoma+cells&rft.au=Sariban-Sohraby%2C+S%3BBalaban%2C+R+S&rft.aulast=Sariban-Sohraby&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Proceedings of Seventy-Fourth Annual Meeting of the American Association for Cancer Research", Mar. 1983, Waverly Press, Inc., 428 E. Preston St., Baltimore, MD 21202, USA, Price: $20.00 Abstract No. 146 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms involved in the separation of isomers by nematic liquid crystal phases AN - 40538350; 0461421 AU - Muschik, G M AU - Shipe, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 8000:PHYSICS AND ASTRONOMY KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40538350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanisms+involved+in+the+separation+of+isomers+by+nematic+liquid+crystal+phases&rft.au=Muschik%2C+G+M%3BShipe%2C+R&rft.aulast=Muschik&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts booklet available to conference registrants. For information on individual papers please contact authors directly N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of allotype-defined probes for comparative studies of mRNAs from spleens and cultured cells of rabbits with defined a@d- and b@d- allotypes AN - 40533485; 0461566 AU - McCartney-Francis, N AU - Alexander, C AU - Bernstein, K AU - Fitzmaurice, L AU - Jacobsen, F AU - Pavirani, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1500:BIOCHEMISTRY KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40533485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Use+of+allotype-defined+probes+for+comparative+studies+of+mRNAs+from+spleens+and+cultured+cells+of+rabbits+with+defined+a%40d-+and+b%40d-+allotypes&rft.au=McCartney-Francis%2C+N%3BAlexander%2C+C%3BBernstein%2C+K%3BFitzmaurice%2C+L%3BJacobsen%2C+F%3BPavirani%2C+A&rft.aulast=McCartney-Francis&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1983, Abstracts booklet available: Division of Immunology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38101, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid development and scaleup for production of the nucleoside antibiotic toyocamycin AN - 40521941; 0395264 AU - Flickinger, M C AU - Boyer, S D AU - Moore, MU AU - Bremmon, C AU - Thomas, M C AU - Greenstein, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2500:CHEMISTRY AND CHEMICAL ENGINEERING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40521941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Rapid+development+and+scaleup+for+production+of+the+nucleoside+antibiotic+toyocamycin&rft.au=Flickinger%2C+M+C%3BBoyer%2C+S+D%3BMoore%2C+MU%3BBremmon%2C+C%3BThomas%2C+M+C%3BGreenstein%2C+M&rft.aulast=Flickinger&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: For information please contact: American Chemical Society, A.T. Winstead, 1155 16th St. NW, Washington, DC 20036, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Murine model for chronic myelogenous leukemia AN - 40516074; 0381225 AU - Fredrickson, T AU - Hartley, J AU - Rowe, W AU - Hagan, M AU - Patchen, M AU - MacVittie, T Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40516074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Murine+model+for+chronic+myelogenous+leukemia&rft.au=Fredrickson%2C+T%3BHartley%2C+J%3BRowe%2C+W%3BHagan%2C+M%3BPatchen%2C+M%3BMacVittie%2C+T&rft.aulast=Fredrickson&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Blood - The Journal of the American Society of Hematology", Nov. 1982, Grune & Stratton, Inc., 111 Fifth Ave., New York, NY 10003, USA, ISSN 0006-4971 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Silent nucleotide in beta super(+) thalassemia gene activates a cryptic splice site in beta globin RNA coding sequence AN - 40514107; 0379655 AU - Humphries, R K AU - Ley, T J AU - Goldsmith, ME AU - Cline, A AU - Kantor, JA AU - Nienhuis, A W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40514107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Silent+nucleotide+in+beta+super%28%2B%29+thalassemia+gene+activates+a+cryptic+splice+site+in+beta+globin+RNA+coding+sequence&rft.au=Humphries%2C+R+K%3BLey%2C+T+J%3BGoldsmith%2C+ME%3BCline%2C+A%3BKantor%2C+JA%3BNienhuis%2C+A+W&rft.aulast=Humphries&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Blood - The Journal of the American Society of Hematology", Nov. 1982, Grune & Stratton, Inc., 111 Fifth Ave., New York, NY 10003, USA, ISSN 0006-4971 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Flow Cytometric Analysis of Trypanosoma cruzi Clones AN - 40512935; 0319133 AU - Dvorak, JA AU - Hall, TE AU - Crane AU - Engel, J C Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40512935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Flow+Cytometric+Analysis+of+Trypanosoma+cruzi+Clones&rft.au=Dvorak%2C+JA%3BHall%2C+TE%3BCrane%3BEngel%2C+J+C&rft.aulast=Dvorak&rft.aufirst=JA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in "Molecular and Biochemical Parasitology", 1982, Elsevier Biomedical Press, Journal Division, P.O. Box 211, 1000 AE Amsterdam, The Netherlands, ISSN 0166-6851; Available as a journal supplement N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human T-T hybridomas secreting lymphokines AN - 40511203; 0380288 AU - Foon, KA AU - Rossio, J AU - Schroff, R W AU - Wahl, S M AU - Abrams, P G AU - Rager, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40511203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+T-T+hybridomas+secreting+lymphokines&rft.au=Foon%2C+KA%3BRossio%2C+J%3BSchroff%2C+R+W%3BWahl%2C+S+M%3BAbrams%2C+P+G%3BRager%2C+H&rft.aulast=Foon&rft.aufirst=KA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Blood - The Journal of the American Society of Hematology", Nov. 1982, Grune & Stratton, Inc., 111 Fifth Ave., New York, NY 10003, USA, ISSN 0006-4971 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapy of multiple myeloma with alternating noncross-resistant chemotherapy combinations AN - 40508070; 0382483 AU - Morstyn, G AU - Schechter, G AU - Ihde, D AU - Carney, D AU - Eddy, J AU - Cohen, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40508070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Therapy+of+multiple+myeloma+with+alternating+noncross-resistant+chemotherapy+combinations&rft.au=Morstyn%2C+G%3BSchechter%2C+G%3BIhde%2C+D%3BCarney%2C+D%3BEddy%2C+J%3BCohen%2C+M&rft.aulast=Morstyn&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Blood - The Journal of the American Society of Hematology", Nov. 1982, Grune & Stratton, Inc., 111 Fifth Ave., New York, NY 10003, USA, ISSN 0006-4971 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Growth Kinetics Analysis of 19 Trypanosoma cruzi Clones AN - 40497937; 0322428 AU - Engel, J C AU - Dvorak, JA AU - Segura, EL AU - Crane Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40497937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Growth+Kinetics+Analysis+of+19+Trypanosoma+cruzi+Clones&rft.au=Engel%2C+J+C%3BDvorak%2C+JA%3BSegura%2C+EL%3BCrane&rft.aulast=Engel&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in "Molecular and Biochemical Parasitology", 1982, Elsevier Biomedical Press, Journal Division, P.O. Box 211, 1000 AE Amsterdam, The Netherlands, ISSN 0166-6851; Available as a journal supplement N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in the Susceptibility of C3H/Hen super(-) Mice to Two Clones of Trypanosoma cruzi) Isolated From a Common Source AN - 40495770; 0320566 AU - Postan, M AU - McDaniel, J P AU - Dvorak, JA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE KW - U 1000:ANIMAL AND PLANT SCIENCE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40495770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differences+in+the+Susceptibility+of+C3H%2FHen+super%28-%29+Mice+to+Two+Clones+of+Trypanosoma+cruzi%29+Isolated+From+a+Common+Source&rft.au=Postan%2C+M%3BMcDaniel%2C+J+P%3BDvorak%2C+JA&rft.aulast=Postan&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in "Molecular and Biochemical Parasitology", 1982, Elsevier Biomedical Press, Journal Division, P.O. Box 211, 1000 AE Amsterdam, The Netherlands, ISSN 0166-6851; Available as a journal supplement N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of Urethane on Glucose Utilization in the Superior Cervical Ganglion and in the Brain AN - 40494389; 0301690 AU - Ito, M AU - Kadekaro, M AU - Sokoloff, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40494389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Influence+of+Urethane+on+Glucose+Utilization+in+the+Superior+Cervical+Ganglion+and+in+the+Brain&rft.au=Ito%2C+M%3BKadekaro%2C+M%3BSokoloff%2C+L&rft.aulast=Ito&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 285.7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Nifedipine and Propranolol on Left Ventricular Function During Exercise in Patients With Coronary Artery Disease AN - 40490164; 0303636 AU - Bonow, RO AU - Rosing AU - Cannon, RO AU - Watson, R M AU - Lipson, L C AU - Palmeri, ST Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40490164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effects+of+Nifedipine+and+Propranolol+on+Left+Ventricular+Function+During+Exercise+in+Patients+With+Coronary+Artery+Disease&rft.au=Bonow%2C+RO%3BRosing%3BCannon%2C+RO%3BWatson%2C+R+M%3BLipson%2C+L+C%3BPalmeri%2C+ST&rft.aulast=Bonow&rft.aufirst=RO&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: CIRCULATION, Oct. 1982, American Heart Association, Distribution Center, 2005 Hightower, Garland, TX 75041, USA, Monograph No. 91 73-077A; Price: $10.00 Abstract No. 83 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunocytochemical Localization of D-2 Binding Sites in the Rodent Forebrain AN - 40486282; 0297633 AU - Church, A C AU - Kleinman, JE AU - Wyatt, R J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40486282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Immunocytochemical+Localization+of+D-2+Binding+Sites+in+the+Rodent+Forebrain&rft.au=Church%2C+A+C%3BKleinman%2C+JE%3BWyatt%2C+R+J&rft.aulast=Church&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 208.4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Action Potential Repolarization Involves a Fast, Calcium-Sensitive Potassium Current in a Vertebrate Neuron AN - 40486183; 0297840 AU - MacDermott, AB AU - Weight, F F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40486183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Action+Potential+Repolarization+Involves+a+Fast%2C+Calcium-Sensitive+Potassium+Current+in+a+Vertebrate+Neuron&rft.au=MacDermott%2C+AB%3BWeight%2C+F+F&rft.aulast=MacDermott&rft.aufirst=AB&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 211.8 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Verapamil and Nifedipine Effects on Symptoms and Exercise Capacity in Patients With Hypertrophic Cardiomyopathy AN - 40485694; 0303746 AU - Rosing AU - Cannon, RO AU - Watson, R M AU - Kent, K M AU - Lakatos, E AU - Epstein, SE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40485694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Comparison+of+Verapamil+and+Nifedipine+Effects+on+Symptoms+and+Exercise+Capacity+in+Patients+With+Hypertrophic+Cardiomyopathy&rft.au=Rosing%3BCannon%2C+RO%3BWatson%2C+R+M%3BKent%2C+K+M%3BLakatos%2C+E%3BEpstein%2C+SE&rft.aulast=Rosing&rft.aufirst=&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: CIRCULATION, Oct. 1982, American Heart Association, Distribution Center, 2005 Hightower, Garland, TX 75041, USA, Monograph No. 91 73-077A; Price: $10.00 Abstract No 95 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Circadian Rhythms in Alpha- and Beta-Adrenergic Receptor Number and Cyclic AMP Production in Rat Cerebral Cortical Slices AN - 40484950; 0296873 AU - Benedito, MA AU - Kafka Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40484950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Circadian+Rhythms+in+Alpha-+and+Beta-Adrenergic+Receptor+Number+and+Cyclic+AMP+Production+in+Rat+Cerebral+Cortical+Slices&rft.au=Benedito%2C+MA%3BKafka&rft.aulast=Benedito&rft.aufirst=MA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 187.9 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Mitral Annular and Submitral Calcification and Their Relation to Cardiovascular Risk Factors in a General Free-Living Population - Preliminary Findings: The Framingham Study AN - 40484738; 0309009 AU - Savage, D D AU - Garrison, R J AU - Castelli, W P AU - McNamara, P M AU - Anderson, S J AU - Kannel, W B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40484738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Prevalence+of+Mitral+Annular+and+Submitral+Calcification+and+Their+Relation+to+Cardiovascular+Risk+Factors+in+a+General+Free-Living+Population+-+Preliminary+Findings%3A+The+Framingham+Study&rft.au=Savage%2C+D+D%3BGarrison%2C+R+J%3BCastelli%2C+W+P%3BMcNamara%2C+P+M%3BAnderson%2C+S+J%3BKannel%2C+W+B&rft.aulast=Savage&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: CIRCULATION, Oct. 1982, American Heart Association, Distribution Center, 2005 Hightower, Garland, TX 75041, USA, Monograph No. 91 73-077A; Price: $10.00 Abstract No. 752 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neonatal Chlordecone Exposure Alters Learning/Retention of Active Avoidance in the Rat AN - 40482940; 0286426 AU - Mactutus, C F AU - Tilson, HA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40482940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neonatal+Chlordecone+Exposure+Alters+Learning%2FRetention+of+Active+Avoidance+in+the+Rat&rft.au=Mactutus%2C+C+F%3BTilson%2C+HA&rft.aulast=Mactutus&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 23.17 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Corticotropin-Releasing Factor on Phospholipid Methylation and ACTH Secretion in Mouse Pituitary Tumor Cells AN - 40482649; 0286119 AU - Hook, VYH AU - Heisler, S AU - Axelrod, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40482649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+Corticotropin-Releasing+Factor+on+Phospholipid+Methylation+and+ACTH+Secretion+in+Mouse+Pituitary+Tumor+Cells&rft.au=Hook%2C+VYH%3BHeisler%2C+S%3BAxelrod%2C+J&rft.aulast=Hook&rft.aufirst=VYH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 18.44 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurochemical and Toxicologic Effects of Anticonvulsant Drugs on Cerebral Cortical Cultures AN - 40479334; 0286423 AU - Neale, E A AU - Sher, P K AU - Nelson, P G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40479334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neurochemical+and+Toxicologic+Effects+of+Anticonvulsant+Drugs+on+Cerebral+Cortical+Cultures&rft.au=Neale%2C+E+A%3BSher%2C+P+K%3BNelson%2C+P+G&rft.aulast=Neale&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 23.16 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Peripheral Nerve Repair With Distributed Mechanical Support AN - 40479167; 0285425 AU - de Medinaceli, L AU - Freed, W J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40479167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Peripheral+Nerve+Repair+With+Distributed+Mechanical+Support&rft.au=de+Medinaceli%2C+L%3BFreed%2C+W+J&rft.aulast=de+Medinaceli&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 12.4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Local Cerebral Glucose Metabolism by Estrogen and Progesterone in the Hypothalamus of Ovariectomized Female Rats AN - 40479104; 0286222 AU - Porrino, L AU - Namba, H AU - Crane, A AU - Jehle, J AU - Sokoloff, L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40479104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modulation+of+Local+Cerebral+Glucose+Metabolism+by+Estrogen+and+Progesterone+in+the+Hypothalamus+of+Ovariectomized+Female+Rats&rft.au=Porrino%2C+L%3BNamba%2C+H%3BCrane%2C+A%3BJehle%2C+J%3BSokoloff%2C+L&rft.aulast=Porrino&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 19.9 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence for Three Kinetically Different Forms of Tyrosine Hydroxylase in Rat Striatum Using BH sub(4) AN - 40478115; 0299003 AU - Miller, L AU - Lovenberg, W Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40478115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Evidence+for+Three+Kinetically+Different+Forms+of+Tyrosine+Hydroxylase+in+Rat+Striatum+Using+BH+sub%284%29&rft.au=Miller%2C+L%3BLovenberg%2C+W&rft.aulast=Miller&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 234.1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Blindness Following Nonvisual Lesions in Monkeys: Partial Lesions and Disconnection Effects AN - 40478102; 0298939 AU - Nakamura, R K AU - Mishkin, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40478102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Chronic+Blindness+Following+Nonvisual+Lesions+in+Monkeys%3A+Partial+Lesions+and+Disconnection+Effects&rft.au=Nakamura%2C+R+K%3BMishkin%2C+M&rft.aulast=Nakamura&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 232.12 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Mnemonic Role for the Hippocampus in Monkeys: Memory for the Location of Objects AN - 40478008; 0285363 AU - Parkinson, J K AU - Mishkin, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40478008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Selective+Mnemonic+Role+for+the+Hippocampus+in+Monkeys%3A+Memory+for+the+Location+of+Objects&rft.au=Parkinson%2C+J+K%3BMishkin%2C+M&rft.aulast=Parkinson&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 11.7 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Benzodiazepines Facilitate the Binding of GABA to GABA but not GABA sub(B) Recognition Sites AN - 40476147; 0292158 AU - Majewska, MD AU - Chuang, D-M AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40476147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Benzodiazepines+Facilitate+the+Binding+of+GABA+to+GABA+but+not+GABA+sub%28B%29+Recognition+Sites&rft.au=Majewska%2C+MD%3BChuang%2C+D-M%3BCosta%2C+E&rft.aulast=Majewska&rft.aufirst=MD&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 111.3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monoclonal Antibodies That Recognize Specific Retina Cell Types, Affect Synaptic Function, or Inhibit Cell Adhesion AN - 40475963; 0287364 AU - Grunwald, G B AU - Trisler, G D AU - Higashida, H AU - Darveniza, P AU - Nirenberg, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40475963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Monoclonal+Antibodies+That+Recognize+Specific+Retina+Cell+Types%2C+Affect+Synaptic+Function%2C+or+Inhibit+Cell+Adhesion&rft.au=Grunwald%2C+G+B%3BTrisler%2C+G+D%3BHigashida%2C+H%3BDarveniza%2C+P%3BNirenberg%2C+M&rft.aulast=Grunwald&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 36.1 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Sodium Channels During Differentiation of Chick Skeletal Muscle in Culture AN - 40475899; 0287326 AU - Baumgold, J AU - Parent, J B AU - Spector, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40475899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Development+of+Sodium+Channels+During+Differentiation+of+Chick+Skeletal+Muscle+in+Culture&rft.au=Baumgold%2C+J%3BParent%2C+J+B%3BSpector%2C+I&rft.aulast=Baumgold&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 33.11 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nigrostriatal Dopamine Terminals Bear Neurotensin Receptors but the Mesolimbic do not AN - 40475555; 0295549 AU - Quirion, R AU - Everist, H D AU - Pert, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40475555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Nigrostriatal+Dopamine+Terminals+Bear+Neurotensin+Receptors+but+the+Mesolimbic+do+not&rft.au=Quirion%2C+R%3BEverist%2C+H+D%3BPert%2C+A&rft.aulast=Quirion&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 160.5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elevated Glucose Utilization in Neurohypophysis and Subfornical Organ of Brattleboro Rats Lacking Vasopressin AN - 40475429; 0287468 AU - Kadekaro, M AU - Gross, P M AU - Holcomb, H H AU - Sokoloff, L AU - Saavedra, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40475429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Elevated+Glucose+Utilization+in+Neurohypophysis+and+Subfornical+Organ+of+Brattleboro+Rats+Lacking+Vasopressin&rft.au=Kadekaro%2C+M%3BGross%2C+P+M%3BHolcomb%2C+H+H%3BSokoloff%2C+L%3BSaavedra%2C+J+M&rft.aulast=Kadekaro&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 39.6 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Determination of Acetylcholine and Choline in Nuronal Tissue by HPLC With Electrochemical Detection AN - 40473169; 0294183 AU - Potter, P E AU - Meek, J L AU - Neff, N H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40473169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Simultaneous+Determination+of+Acetylcholine+and+Choline+in+Nuronal+Tissue+by+HPLC+With+Electrochemical+Detection&rft.au=Potter%2C+P+E%3BMeek%2C+J+L%3BNeff%2C+N+H&rft.aulast=Potter&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 143.8 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cortical Projections of Area MT in the Macaque AN - 40472958; 0297166 AU - Ungerleider, L G AU - Desimone, R AU - Mishkin, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40472958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Cortical+Projections+of+Area+MT+in+the+Macaque&rft.au=Ungerleider%2C+L+G%3BDesimone%2C+R%3BMishkin%2C+M&rft.aulast=Ungerleider&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 193.4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Motor Cortex of the Rat: Connectivity and Single Unit Discharge During Movement AN - 40472062; 0294718 AU - Donoghue, J P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40472062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Motor+Cortex+of+the+Rat%3A+Connectivity+and+Single+Unit+Discharge+During+Movement&rft.au=Donoghue%2C+J+P&rft.aulast=Donoghue&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 150.10 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sensory Responses of Pyramidal Tract Neurons in Unanesthetized Rhesus Monkey AN - 40470425; 0294685 AU - Wise, S P AU - Fromm, C AU - Evarts, E V Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40470425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Sensory+Responses+of+Pyramidal+Tract+Neurons+in+Unanesthetized+Rhesus+Monkey&rft.au=Wise%2C+S+P%3BFromm%2C+C%3BEvarts%2C+E+V&rft.aulast=Wise&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: 1982, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, USA, Abstracts volume available. Price: $10.00 Abstract No. 150.4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biosynthesis of Fredericamycin, a New Antitumor Antibiotic AN - 40463669; 0273674 AU - Byrne, K M AU - Wei, T T AU - White, R J AU - Hilton, B AU - Pandey, R C AU - Misra, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:BIOLOGY GENERAL KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40463669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Biosynthesis+of+Fredericamycin%2C+a+New+Antitumor+Antibiotic&rft.au=Byrne%2C+K+M%3BWei%2C+T+T%3BWhite%2C+R+J%3BHilton%2C+B%3BPandey%2C+R+C%3BMisra%2C+R&rft.aulast=Byrne&rft.aufirst=K&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Program and Abstracts of the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy", 1982, American Society for Microbiology, 1913 I St., NW, Washington, DC 20006 USA, Abstracts and program booklet $10.00 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of Adenylate Cyclase by Cholera Toxin: Evidence for the Generation of Active Al Peptide in Cultured Cells AN - 40453009; 0214987 AU - Kassis, S AU - Hagmann, J AU - Fishman, H AU - Chang, P P AU - Moss, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40453009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Activation+of+Adenylate+Cyclase+by+Cholera+Toxin%3A+Evidence+for+the+Generation+of+Active+Al+Peptide+in+Cultured+Cells&rft.au=Kassis%2C+S%3BHagmann%2C+J%3BFishman%2C+H%3BChang%2C+P+P%3BMoss%2C+J&rft.aulast=Kassis&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhancement of Intercalator-Induced DNA Breakage in Mammalian Cells by Dimethyl Sulfoxide (DMSO) AN - 40446840; 0209704 AU - Pommier, Y AU - Kerrigan, D AU - Zwelling, LA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40446840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Enhancement+of+Intercalator-Induced+DNA+Breakage+in+Mammalian+Cells+by+Dimethyl+Sulfoxide+%28DMSO%29&rft.au=Pommier%2C+Y%3BKerrigan%2C+D%3BZwelling%2C+LA&rft.aulast=Pommier&rft.aufirst=Y&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pyrroline Carboxylic Acids: Mediators of a Metabolic Interaction Between Hepatocytes and Fibroblasts AN - 40445112; 0210405 AU - Hagedorn, CH AU - Phang, J M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40445112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Pyrroline+Carboxylic+Acids%3A+Mediators+of+a+Metabolic+Interaction+Between+Hepatocytes+and+Fibroblasts&rft.au=Hagedorn%2C+CH%3BPhang%2C+J+M&rft.aulast=Hagedorn&rft.aufirst=CH&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role for Interleukin-2 in the Expansion of Lung T-Lymphocyte Population in Pulmonary Sarcoidosis AN - 40443257; 0210161 AU - Pinkston, P AU - Bitterman, P AU - Crystal, R G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40443257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+for+Interleukin-2+in+the+Expansion+of+Lung+T-Lymphocyte+Population+in+Pulmonary+Sarcoidosis&rft.au=Pinkston%2C+P%3BBitterman%2C+P%3BCrystal%2C+R+G&rft.aulast=Pinkston&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Defect in Neutrophil (PMN) Superoxide Generation by the Chemoattractant F-MET-LEU-PHE (FMLP) in Pregnancy AN - 40441211; 0211548 AU - Cotton, D AU - Seligmann, B AU - O'Brien, W AU - Gallin, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40441211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Selective+Defect+in+Neutrophil+%28PMN%29+Superoxide+Generation+by+the+Chemoattractant+F-MET-LEU-PHE+%28FMLP%29+in+Pregnancy&rft.au=Cotton%2C+D%3BSeligmann%2C+B%3BO%27Brien%2C+W%3BGallin%2C+J&rft.aulast=Cotton&rft.aufirst=D&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hypothalamic-Pituitary Function in Fetal and Neonatal Monkeys: Inhibition by the Gestational Milieu AN - 40440650; 0221447 AU - Williams, R F AU - Yonekura, M L Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40440650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Hypothalamic-Pituitary+Function+in+Fetal+and+Neonatal+Monkeys%3A+Inhibition+by+the+Gestational+Milieu&rft.au=Williams%2C+R+F%3BYonekura%2C+M+L&rft.aulast=Williams&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: Biology of Reproduction, 1982, Society for the Study of Reproduction, 309 West Clark St., Champaign, IL 61820, ISSN: 0006-3363 Abstract No. 173 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppression of In Vitro Lymphocyte Proliferation Due to In Vitro Histamine Release in Patients With Schistosomiasis AN - 40440093; 0208006 AU - Hofstetter, M AU - Fasano, M B AU - Ottesen, E A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40440093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Suppression+of+In+Vitro+Lymphocyte+Proliferation+Due+to+In+Vitro+Histamine+Release+in+Patients+With+Schistosomiasis&rft.au=Hofstetter%2C+M%3BFasano%2C+M+B%3BOttesen%2C+E+A&rft.aulast=Hofstetter&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antigen Specific Human B Cell Activation by Mixed Lymphocyte Culture Supernatants AN - 40439884; 0207721 AU - Peters, M AU - Fauci, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40439884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Antigen+Specific+Human+B+Cell+Activation+by+Mixed+Lymphocyte+Culture+Supernatants&rft.au=Peters%2C+M%3BFauci%2C+A+S&rft.aulast=Peters&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Rise in Left Ventricular Filling Pressure on Coronary Collateral Function AN - 40434345; 0206892 AU - Bolli, R AU - Goldstein, R E AU - Brandon, T A AU - Miller, R R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40434345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Effect+of+Rise+in+Left+Ventricular+Filling+Pressure+on+Coronary+Collateral+Function&rft.au=Bolli%2C+R%3BGoldstein%2C+R+E%3BBrandon%2C+T+A%3BMiller%2C+R+R&rft.aulast=Bolli&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Uptake of Gallium-67 by Alveolar Macrophages Activated by Exposure to Inorganic Compounds AN - 40432283; 0177080 AU - Bakshi, G C AU - Moritz, ED AU - Rossi, G A AU - Gadek, JE AU - Crystal, R G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40432283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Uptake+of+Gallium-67+by+Alveolar+Macrophages+Activated+by+Exposure+to+Inorganic+Compounds&rft.au=Bakshi%2C+G+C%3BMoritz%2C+ED%3BRossi%2C+G+A%3BGadek%2C+JE%3BCrystal%2C+R+G&rft.aulast=Bakshi&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Delineation of Optimal Conditions for Producing Hybridomas From Human Peripheral Blood B Lymphocytes of Immunized Subjects AN - 40428935; 0207128 AU - Butler, J L AU - Lane, H C AU - Fauci, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40428935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Delineation+of+Optimal+Conditions+for+Producing+Hybridomas+From+Human+Peripheral+Blood+B+Lymphocytes+of+Immunized+Subjects&rft.au=Butler%2C+J+L%3BLane%2C+H+C%3BFauci%2C+A+S&rft.aulast=Butler&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: "Clinical Research", Apr. 1982, American Federation for Clinical Research, 6900 Grove Rd., Thorofare, NJ 08086 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissolution and Reconstitution of Tubular Myelinlike Structures From the Lungs of Patients With Pulmonary Alveolar Proteinosis AN - 40428306; 0177890 AU - Hook, GER AU - Gilmore, L B AU - Talley, F A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40428306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dissolution+and+Reconstitution+of+Tubular+Myelinlike+Structures+From+the+Lungs+of+Patients+With+Pulmonary+Alveolar+Proteinosis&rft.au=Hook%2C+GER%3BGilmore%2C+L+B%3BTalley%2C+F+A&rft.aulast=Hook&rft.aufirst=GER&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modification of Opioid Peptides Level in the Hypothalamus by Chronic Treatment With d-Fenfluramine AN - 40422075; 0158481 AU - Harsing, L G AU - Yang, H-YT AU - Govoni, S AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40422075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modification+of+Opioid+Peptides+Level+in+the+Hypothalamus+by+Chronic+Treatment+With+d-Fenfluramine&rft.au=Harsing%2C+L+G%3BYang%2C+H-YT%3BGovoni%2C+S%3BCosta%2C+E&rft.aulast=Harsing&rft.aufirst=L&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 257.12 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Origin of the Cholecystokinin-Containing Efferents of the Caudatoputamen in the Rat AN - 40421163; 0156238 AU - Beinfeld, M C AU - Meyer, D K AU - Oertel, W H AU - Brownstein, MJ Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40421163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Origin+of+the+Cholecystokinin-Containing+Efferents+of+the+Caudatoputamen+in+the+Rat&rft.au=Beinfeld%2C+M+C%3BMeyer%2C+D+K%3BOertel%2C+W+H%3BBrownstein%2C+MJ&rft.aulast=Beinfeld&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 197.5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laminar Analysis of Opiate Receptor Distribution in Rat Cerebral Cortex AN - 40419649; 0154743 AU - Lewis, ME AU - Pert, A AU - Pert, C B AU - Herkenham, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40419649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Laminar+Analysis+of+Opiate+Receptor+Distribution+in+Rat+Cerebral+Cortex&rft.au=Lewis%2C+ME%3BPert%2C+A%3BPert%2C+C+B%3BHerkenham%2C+M&rft.aulast=Lewis&rft.aufirst=ME&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 161.9 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dermal Exposure to Paraquat as an Occupational Cause of Interstitial Lung Disease AN - 40418871; 0175403 AU - Keogh, BA AU - Schoenberger, C AU - Price, D L AU - Crystal, R G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 3500:CLINICAL MEDICINE KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40418871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dermal+Exposure+to+Paraquat+as+an+Occupational+Cause+of+Interstitial+Lung+Disease&rft.au=Keogh%2C+BA%3BSchoenberger%2C+C%3BPrice%2C+D+L%3BCrystal%2C+R+G&rft.aulast=Keogh&rft.aufirst=BA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Abstracts in: American Review of Respiratory Diseases, Apr. 1982, American Lung Association, 1740 Broadway, New York, NY 10019 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuroendocrine, Neuroanatomical and Neuropharmacological Studies of a Putative Ventral Tegmental Area/N. Tractus Diagonalis Neuronal System AN - 40416968; 0158436 AU - Muth, E A AU - Jacobowitz, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40416968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neuroendocrine%2C+Neuroanatomical+and+Neuropharmacological+Studies+of+a+Putative+Ventral+Tegmental+Area%2FN.+Tractus+Diagonalis+Neuronal+System&rft.au=Muth%2C+E+A%3BJacobowitz%2C+D+M&rft.aulast=Muth&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 256.14 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modification of Cholinergic Dynamics in Rat Brain by Intraventricular Administration of Adenosine Analogs AN - 40415405; 0154649 AU - Murray, T F AU - Cheney, D L AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40415405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Modification+of+Cholinergic+Dynamics+in+Rat+Brain+by+Intraventricular+Administration+of+Adenosine+Analogs&rft.au=Murray%2C+T+F%3BCheney%2C+D+L%3BCosta%2C+E&rft.aulast=Murray&rft.aufirst=T&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 159.13 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - super(3)H-Saxitoxin Binding and Scorpion Toxin-Stimulated super(22)NA super(+) Fluxes Show Different Developmental Kinetics AN - 40415351; 0143819 AU - Baumgold, J AU - Parent, J B AU - Spector, I Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40415351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=super%283%29H-Saxitoxin+Binding+and+Scorpion+Toxin-Stimulated+super%2822%29NA+super%28%2B%29+Fluxes+Show+Different+Developmental+Kinetics&rft.au=Baumgold%2C+J%3BParent%2C+J+B%3BSpector%2C+I&rft.aulast=Baumgold&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 83.4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Olfactory Bulb Adenylate Cyclase: Interactions Between Dopamine and Insulin AN - 40411900; 0139385 AU - Barbaccia, M L AU - Chuang, D M AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40411900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Regulation+of+Olfactory+Bulb+Adenylate+Cyclase%3A+Interactions+Between+Dopamine+and+Insulin&rft.au=Barbaccia%2C+M+L%3BChuang%2C+D+M%3BCosta%2C+E&rft.aulast=Barbaccia&rft.aufirst=M&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 7.13 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purification and Characterization of an Endogenous Brain Peptide That Competes With super(3)H-Diazepam Binding AN - 40410664; 0156793 AU - Guidotti, A AU - Ebstein, B AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40410664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Purification+and+Characterization+of+an+Endogenous+Brain+Peptide+That+Competes+With+super%283%29H-Diazepam+Binding&rft.au=Guidotti%2C+A%3BEbstein%2C+B%3BCosta%2C+E&rft.aulast=Guidotti&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 208.4 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Action of Antidepressants AN - 40410160; 0143671 AU - Costa, E AU - Langer, S Z AU - Goodwin, F AU - Sulser, F AU - Fuxe, K AU - Snyder, SH Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40410160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Mechanism+of+Action+of+Antidepressants&rft.au=Costa%2C+E%3BLanger%2C+S+Z%3BGoodwin%2C+F%3BSulser%2C+F%3BFuxe%2C+K%3BSnyder%2C+SH&rft.aulast=Costa&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 74 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in the Brain Recognition Sites for Typical and Atypical Antidepressants AN - 40408744; 0160072 AU - Brunello, N AU - Chuang, D M AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40408744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Differences+in+the+Brain+Recognition+Sites+for+Typical+and+Atypical+Antidepressants&rft.au=Brunello%2C+N%3BChuang%2C+D+M%3BCosta%2C+E&rft.aulast=Brunello&rft.aufirst=N&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 298.16 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple Binding Sites for Ouabain in the Central Nervous System AN - 40407392; 0143686 AU - Hauger, R AU - Do, H M AU - Goodwin, F K AU - Paul, S M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40407392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Multiple+Binding+Sites+for+Ouabain+in+the+Central+Nervous+System&rft.au=Hauger%2C+R%3BDo%2C+H+M%3BGoodwin%2C+F+K%3BPaul%2C+S+M&rft.aulast=Hauger&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 76.5 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monkey's Premotor Cortex AN - 40406496; 0139507 AU - Wise, S P AU - Weinrich, M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40406496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Monkey%27s+Premotor+Cortex&rft.au=Wise%2C+S+P%3BWeinrich%2C+M&rft.aulast=Wise&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 9.3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stimulation of Dopamine Receptors Inhibits VIP Sensitive Adenylate Cyclase Activity in Male Rat Anterior Pituitary AN - 40406411; 0142662 AU - Onali, P AU - Schwartz, J P AU - Costa, E Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40406411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Stimulation+of+Dopamine+Receptors+Inhibits+VIP+Sensitive+Adenylate+Cyclase+Activity+in+Male+Rat+Anterior+Pituitary&rft.au=Onali%2C+P%3BSchwartz%2C+J+P%3BCosta%2C+E&rft.aulast=Onali&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 51.3 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Calcium Transients Elicited by Synaptic and Electrical Membrane Activation and by Theophylline Measured in Bullfrog Neurons Using Arsenazo III AN - 40400352; 0139409 AU - Smith, S J AU - MacDermott, AB AU - Weight, F F Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:EXPERIMENTAL MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40400352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Intracellular+Calcium+Transients+Elicited+by+Synaptic+and+Electrical+Membrane+Activation+and+by+Theophylline+Measured+in+Bullfrog+Neurons+Using+Arsenazo+III&rft.au=Smith%2C+S+J%3BMacDermott%2C+AB%3BWeight%2C+F+F&rft.aulast=Smith&rft.aufirst=S&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: In "Society for Neuroscience Abstracts", 1981, Society for Neuroscience, 9650 Rockville Pike, Bethesda, MD 20814, ISBN: 0-916110-11-7; LC No. 75-7761 Abstract No. 8.6 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of pulegone in B6C3F1 mice and F-344 rats AN - 39267520; 3524511 AU - Lebetkin, E H AU - Burka, L T AU - Chen, L J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39267520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distribution+of+pulegone+in+B6C3F1+mice+and+F-344+rats&rft.au=Lebetkin%2C+E+H%3BBurka%2C+L+T%3BChen%2C+L+J&rft.aulast=Lebetkin&rft.aufirst=E&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; 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3550726 AU - McKay, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 4500:Experimental Medicine KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39257480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Building+brains+with+stem+cells&rft.au=McKay%2C+R&rft.aulast=McKay&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: BioConferences International, Inc., 2 Madison Avenue, Larchmont, NY 10538, USA; phone: 914-834-3100; fax: 914-834-3689; email: hmatysko@liebertpub.com; URL: www.bioconferences.com/ N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Secretion of GP63 by Leishmania and other kinetoplastida AN - 39254552; 3547285 AU - Jaffe, CL AU - Dwyer, D M Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39254552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Secretion+of+GP63+by+Leishmania+and+other+kinetoplastida&rft.au=Jaffe%2C+CL%3BDwyer%2C+D+M&rft.aulast=Jaffe&rft.aufirst=CL&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Tropical Medicine and Hygiene, 3088 Briarcliff Rd., Ste. 11A, Atlanta, GA 30329, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A quantitative estimate of individual genetic vulnerability for a multifactorial condition: Application to bipolar illness AN - 39241858; 3537306 AU - Nurnberger, J AU - Foroud, T AU - Meyer, E T AU - Hu, K L AU - Flury, L AU - Su, J Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39241858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=A+quantitative+estimate+of+individual+genetic+vulnerability+for+a+multifactorial+condition%3A+Application+to+bipolar+illness&rft.au=Nurnberger%2C+J%3BForoud%2C+T%3BMeyer%2C+E+T%3BHu%2C+K+L%3BFlury%2C+L%3BSu%2C+J&rft.aulast=Nurnberger&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., 605 Third Ave., New York, NY, 10158, USA; phone: (212) 850 6011; fax: (212) 850 6008; email: permreq@wiley.com; URL: www.wiley.com N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Role of map kinases (MAPKs) and apoptosis in arsenic-induced malignant transformation and self-tolerance AN - 39222734; 3525183 AU - Qu, W AU - Bortner, C AU - Hobson, M AU - Liu, J AU - Knowles, T AU - Waalkes, M P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39222734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Role+of+map+kinases+%28MAPKs%29+and+apoptosis+in+arsenic-induced+malignant+transformation+and+self-tolerance&rft.au=Qu%2C+W%3BBortner%2C+C%3BHobson%2C+M%3BLiu%2C+J%3BKnowles%2C+T%3BWaalkes%2C+M+P&rft.aulast=Qu&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Complete protection from homologous challenge of Aotus monkeys immunized with the CD36-binding region of PfEMP1 AN - 39210166; 3547237 AU - Gamain, G AU - Barnwell, J AU - Sullivan, J AU - Collins, W E AU - Miller, L H AU - Baruch, DI Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39210166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Complete+protection+from+homologous+challenge+of+Aotus+monkeys+immunized+with+the+CD36-binding+region+of+PfEMP1&rft.au=Gamain%2C+G%3BBarnwell%2C+J%3BSullivan%2C+J%3BCollins%2C+W+E%3BMiller%2C+L+H%3BBaruch%2C+DI&rft.aulast=Gamain&rft.aufirst=G&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: American Society of Tropical Medicine and Hygiene, 3088 Briarcliff Rd., Ste. 11A, Atlanta, GA 30329, USA N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Population genetics of complex alcoholism AN - 39201693; 3537186 AU - Long, J C AU - Brooks, J AU - Bergen, A W AU - Kittles, R A AU - Goldman, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39201693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Population+genetics+of+complex+alcoholism&rft.au=Long%2C+J+C%3BBrooks%2C+J%3BBergen%2C+A+W%3BKittles%2C+R+A%3BGoldman%2C+D&rft.aulast=Long&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: John Wiley & Sons, Inc., 605 Third Ave., New York, NY, 10158, USA; phone: (212) 850 6011; fax: (212) 850 6008; email: permreq@wiley.com; URL: www.wiley.com N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Developmental exposure to TCDD and mercuric chloride in autoimmune-prone MRL/lpr mice AN - 39194665; 3524499 AU - Smith, DA AU - Germolec Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39194665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Developmental+exposure+to+TCDD+and+mercuric+chloride+in+autoimmune-prone+MRL%2Flpr+mice&rft.au=Smith%2C+DA%3BGermolec&rft.aulast=Smith&rft.aufirst=DA&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Semantic boundaries are intact in schizophrenia AN - 39190634; 3530151 AU - Schwartz, A AU - Elvevaeg, B AU - Weinberger AU - Goldberg, TE Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39190634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Semantic+boundaries+are+intact+in+schizophrenia&rft.au=Schwartz%2C+A%3BElvevaeg%2C+B%3BWeinberger%3BGoldberg%2C+TE&rft.aulast=Schwartz&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Cognitive Neuroscience Society, 6162 Moore Hall, Dartmouth College, Hanover, NH 03755, USA; phone: 603-646-1189; email: cns@dartmouth.edu; URL: www.dartmouth.edu/~cns. Poster Paper N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Tramtrack co-operates to prevent ectopic sensilla development in the adult PNS AN - 39189126; 3519202 AU - Badenhorst, P AU - Travers, A Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39189126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Tramtrack+co-operates+to+prevent+ectopic+sensilla+development+in+the+adult+PNS&rft.au=Badenhorst%2C+P%3BTravers%2C+A&rft.aulast=Badenhorst&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Genetics Society of America, 9650 Rockville Pike, Bethesda, Md 20814-3998, USA; phone: (301) 571-1825; fax: (301) 530-7079; email: society@genetics.faseb.org; URL: http://www.faseb.org/genetics/gsa/gsamenu.htm. Paper No. 744B N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Okadaic acid induced apoptosis and resistance in HT 1080 human fibrosarcoma cells AN - 39186839; 3526028 AU - Zhao, W AU - Merrick, BA Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39186839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Okadaic+acid+induced+apoptosis+and+resistance+in+HT+1080+human+fibrosarcoma+cells&rft.au=Zhao%2C+W%3BMerrick%2C+BA&rft.aulast=Zhao&rft.aufirst=W&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Dermal and oral exposure of TCDD in TG.AC mice: Dose- and time-response studies AN - 39178523; 3526007 AU - Van Birgelen, APJ AU - Johnson, J D AU - Fuciarelli, A F AU - Toft, J D AU - Hejtmancik, M AU - Mahler, J AU - Bucher, J R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science KW - U 4300: Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39178523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Dermal+and+oral+exposure+of+TCDD+in+TG.AC+mice%3A+Dose-+and+time-response+studies&rft.au=Van+Birgelen%2C+APJ%3BJohnson%2C+J+D%3BFuciarelli%2C+A+F%3BToft%2C+J+D%3BHejtmancik%2C+M%3BMahler%2C+J%3BBucher%2C+J+R&rft.aulast=Van+Birgelen&rft.aufirst=APJ&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: The Society of Toxicology, 1767 Business Center Drive, Suite 302, Reston, VA 20190-5332, USA; phone: (703) 438-3115; fax: (703) 438-3113; email: sothq@toxicology.org; URL: www.toxicology.org N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Telomeric interactions have genetic consequences AN - 39174223; 3518700 AU - Mason, J M AU - Golubovsky, MD AU - Konev, A Y AU - Walter, M F AU - Biessmann, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39174223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Telomeric+interactions+have+genetic+consequences&rft.au=Mason%2C+J+M%3BGolubovsky%2C+MD%3BKonev%2C+A+Y%3BWalter%2C+M+F%3BBiessmann%2C+H&rft.aulast=Mason&rft.aufirst=J&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Genetics Society of America, 9650 Rockville Pike, Bethesda, Md 20814-3998, USA; phone: (301) 571-1825; fax: (301) 530-7079; email: society@genetics.faseb.org; URL: http://www.faseb.org/genetics/gsa/gsamenu.htm. Paper No. 241 N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Distributed neural systems for the generation of visual images AN - 39173487; 3529968 AU - Ishai, A AU - Haxby, J V AU - Ungerleider, L G Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 1000:Animal and Plant Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39173487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Distributed+neural+systems+for+the+generation+of+visual+images&rft.au=Ishai%2C+A%3BHaxby%2C+J+V%3BUngerleider%2C+L+G&rft.aulast=Ishai&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Cognitive Neuroscience Society, 6162 Moore Hall, Dartmouth College, Hanover, NH 03755, USA; phone: 603-646-1189; email: cns@dartmouth.edu; URL: www.dartmouth.edu/~cns. Poster Paper N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Relationship between alcoholism and depression: A molecular analysis AN - 39167974; 3504284 AU - Nurnberger, JI AU - Foroud, T AU - Flury, L AU - Meyer, E T AU - Crowe, R AU - Hesselbrock, V AU - Porjesz, B AU - Reich, T AU - Schuckit, M AU - Begleiter, H Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39167974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Relationship+between+alcoholism+and+depression%3A+A+molecular+analysis&rft.au=Nurnberger%2C+JI%3BForoud%2C+T%3BFlury%2C+L%3BMeyer%2C+E+T%3BCrowe%2C+R%3BHesselbrock%2C+V%3BPorjesz%2C+B%3BReich%2C+T%3BSchuckit%2C+M%3BBegleiter%2C+H&rft.aulast=Nurnberger&rft.aufirst=JI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Stockton Press, Houndmills, Basingstoke, Hants RG21 6XS, UK; phone: 44 0 1256 329 242; URL: www.stockton-press.co.uk, Abstracts available. Price L104 or $172. Contact Stockton for exact single issue rate. N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Human TH01 tetra-tandem repeat and its role in schizophrenia and bipolar disorder AN - 39148693; 3504346 AU - Mazzanti, C M AU - Malhotra, A AU - Rotondo, A AU - Lipsky, R AU - Kolachana, B AU - Bozak, D AU - Vyas, G AU - Goldman, D Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39148693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Human+TH01+tetra-tandem+repeat+and+its+role+in+schizophrenia+and+bipolar+disorder&rft.au=Mazzanti%2C+C+M%3BMalhotra%2C+A%3BRotondo%2C+A%3BLipsky%2C+R%3BKolachana%2C+B%3BBozak%2C+D%3BVyas%2C+G%3BGoldman%2C+D&rft.aulast=Mazzanti&rft.aufirst=C&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Stockton Press, Houndmills, Basingstoke, Hants RG21 6XS, UK; phone: 44 0 1256 329 242; URL: www.stockton-press.co.uk, Abstracts available. Price L104 or $172. Contact Stockton for exact single issue rate. N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - New analyses of the NIMH bipolar dataset AN - 39147354; 3504330 AU - Nurnberger, JI AU - Foroud, T AU - Flury, L AU - Meyer, E T AU - Edenberg, H AU - DePaulo, J R AU - Stine, O C AU - Blehar, M C AU - Detera-Wadleigh, S AU - Gershon, E S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39147354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=New+analyses+of+the+NIMH+bipolar+dataset&rft.au=Nurnberger%2C+JI%3BForoud%2C+T%3BFlury%2C+L%3BMeyer%2C+E+T%3BEdenberg%2C+H%3BDePaulo%2C+J+R%3BStine%2C+O+C%3BBlehar%2C+M+C%3BDetera-Wadleigh%2C+S%3BGershon%2C+E+S&rft.aulast=Nurnberger&rft.aufirst=JI&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Stockton Press, Houndmills, Basingstoke, Hants RG21 6XS, UK; phone: 44 0 1256 329 242; URL: www.stockton-press.co.uk, Abstracts available. Price L104 or $172. Contact Stockton for exact single issue rate. N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Essential posttranscriptional control systems in retroviruses: Role in viral load AN - 39142758; 3500838 AU - Felber, B Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39142758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Essential+posttranscriptional+control+systems+in+retroviruses%3A+Role+in+viral+load&rft.au=Felber%2C+B&rft.aulast=Felber&rft.aufirst=B&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute for Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA; phone: 410-706-8614; email: valuckas@umbi.umd.edu; URL: www.ihv.org, Abstracts available. Contact IHV for price. N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Preliminary results of a pilot study on the administration of interleukin 12 (IL-12) to patients with AIDS-associated Kaposi's sarcoma (KS) AN - 39141898; 3500937 AU - Yarchoan, R Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39141898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Preliminary+results+of+a+pilot+study+on+the+administration+of+interleukin+12+%28IL-12%29+to+patients+with+AIDS-associated+Kaposi%27s+sarcoma+%28KS%29&rft.au=Yarchoan%2C+R&rft.aulast=Yarchoan&rft.aufirst=R&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute for Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA; phone: 410-706-8614; email: valuckas@umbi.umd.edu; URL: www.ihv.org, Abstracts available. Contact IHV for price. N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - Corticosteroids and cyclosporine directly stimulate human herpesvirus 8 reactivation in latently infected cells: Implications for development of Kaposi's sarcoma AN - 39135976; 3500939 AU - Zoeteweij, P Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39135976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Corticosteroids+and+cyclosporine+directly+stimulate+human+herpesvirus+8+reactivation+in+latently+infected+cells%3A+Implications+for+development+of+Kaposi%27s+sarcoma&rft.au=Zoeteweij%2C+P&rft.aulast=Zoeteweij&rft.aufirst=P&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute for Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA; phone: 410-706-8614; email: valuckas@umbi.umd.edu; URL: www.ihv.org, Abstracts available. 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N1 - Last updated - 2011-10-26 ER - TY - CPAPER T1 - AIDS paradigm: Scientific and policy lessons for the 21st century AN - 39118210; 3500874 AU - Fauci, A S Y1 - 2000/12/31/ PY - 2000 DA - 2000 Dec 31 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39118210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=AIDS+paradigm%3A+Scientific+and+policy+lessons+for+the+21st+century&rft.au=Fauci%2C+A+S&rft.aulast=Fauci&rft.aufirst=A&rft.date=2000-12-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Institute for Human Virology, 725 West Lombard Street, Baltimore, MD 21201, USA; phone: 410-706-8614; email: valuckas@umbi.umd.edu; URL: www.ihv.org, Abstracts available. Contact IHV for price. N1 - Last updated - 2011-10-26 ER - TY - JOUR T1 - Expression of a smaller lecithin:retinol acyl transferase transcript and reduced retinol esterification in MCF-7 cells. AN - 72556785; 11162450 AB - Retinyl ester concentration is regulated by retinoic acid (RA) through an autoregulatory loop, which acts on lecithin:retinol acyltransferase (LRAT). We tested whether retinol esterification activity is downregulated in human mammary carcinoma cells and whether LRAT expression is RAR-regulated. Normal human mammary epithelial (HMEC) cells expressed a retinoid-upregulated 5-kb LRAT transcript and synthesized retinyl esters from 3H-retinol. Human carcinoma MCF-7 cells failed to express the 5-kb LRAT transcript and to synthesize retinyl esters. Instead, they expressed a 2.7-kb LRAT transcript. Both transcripts were upregulated by RA. Stable expression of the dominant-negative RARalpha403 blunted the up-regulation of LRAT mRNA by RA. We conclude that retinol esterification is decreased in MCF-7 vs normal mammary cells; that these cancer cells express a shorter (2.7 kb) LRAT transcript, and that retinoid receptors are involved in the regulation of LRAT-mediated retinyl ester synthesis by RA. JF - Biochemical and biophysical research communications AU - Andreola, F AU - Giandomenico, V AU - Spero, R AU - De Luca, L M AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. Y1 - 2000/12/29/ PY - 2000 DA - 2000 Dec 29 SP - 920 EP - 924 VL - 279 IS - 3 SN - 0006-291X, 0006-291X KW - RNA, Messenger KW - 0 KW - Receptors, Retinoic Acid KW - Retinoids KW - Tritium KW - 10028-17-8 KW - Vitamin A KW - 11103-57-4 KW - Acyltransferases KW - EC 2.3.- KW - lecithin-retinol acyltransferase KW - EC 2.3.1.- KW - Index Medicus KW - Humans KW - RNA, Messenger -- drug effects KW - Transcription, Genetic KW - Retinoids -- pharmacology KW - Molecular Weight KW - Receptors, Retinoic Acid -- physiology KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- enzymology KW - Esterification KW - RNA, Messenger -- metabolism KW - Tumor Cells, Cultured KW - Up-Regulation -- drug effects KW - Acyltransferases -- biosynthesis KW - Acyltransferases -- genetics KW - Vitamin A -- metabolism KW - Acyltransferases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72556785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Expression+of+a+smaller+lecithin%3Aretinol+acyl+transferase+transcript+and+reduced+retinol+esterification+in+MCF-7+cells.&rft.au=Andreola%2C+F%3BGiandomenico%2C+V%3BSpero%2C+R%3BDe+Luca%2C+L+M&rft.aulast=Andreola&rft.aufirst=F&rft.date=2000-12-29&rft.volume=279&rft.issue=3&rft.spage=920&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A stereospecific synthesis of (+/-)-5,8-disubstituted indolizidines and (+/-)-1,4-disubstituted quinolizidines found in poison frog skins. AN - 72475319; 11149832 AB - An efficient, high-yield stereospecific route to three (+/-)-5, 8-disubstituted indolizidines, (209B (I), 209I (II), 223J (III)) and two (+/-)-1,4-disubstituted quinolizidines (207I (IV), 233A (V)), racemates of alkaloids found in the skins of neotropical and Madagascan poison frogs is reported. The structures of the natural alkaloids were thereby established by chiral GC comparison with the exception of indolizidine 209B (I) for which a natural 209B could no longer be detected. JF - The Journal of organic chemistry AU - Michel, P AU - Rassat, A AU - Daly, J W AU - Spande, T F AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0820, USA. Y1 - 2000/12/29/ PY - 2000 DA - 2000 Dec 29 SP - 8908 EP - 8918 VL - 65 IS - 26 SN - 0022-3263, 0022-3263 KW - Indicators and Reagents KW - 0 KW - Indolizines KW - Quinolizines KW - Index Medicus KW - Spectrophotometry, Infrared KW - Oxidation-Reduction KW - Spectroscopy, Fourier Transform Infrared KW - Mass Spectrometry KW - Animals KW - Magnetic Resonance Spectroscopy KW - Alkylation KW - Skin -- chemistry KW - Quinolizines -- chemical synthesis KW - Indolizines -- chemical synthesis KW - Ranidae KW - Animals, Poisonous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72475319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+organic+chemistry&rft.atitle=A+stereospecific+synthesis+of+%28%2B%2F-%29-5%2C8-disubstituted+indolizidines+and+%28%2B%2F-%29-1%2C4-disubstituted+quinolizidines+found+in+poison+frog+skins.&rft.au=Michel%2C+P%3BRassat%2C+A%3BDaly%2C+J+W%3BSpande%2C+T+F&rft.aulast=Michel&rft.aufirst=P&rft.date=2000-12-29&rft.volume=65&rft.issue=26&rft.spage=8908&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+organic+chemistry&rft.issn=00223263&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons. AN - 72538181; 11146106 AB - Peroxidation of membrane lipids occurs in many different neurodegenerative conditions including stroke, and Alzheimer's and Parkinson's diseases. Recent findings suggest that lipid peroxidation can promote neuronal death by a mechanism involving production of the toxic aldehyde 4-hydroxy-2,3-nonenal (HNE), which may act by covalently modifying proteins and impairing their function. The transcription factor NF-kappa B can prevent neuronal death in experimental models of neurodegenerative disorders by inducing the expression of anti-apoptotic proteins including Bcl-2 and manganese superoxide dismutase. We now report that HNE selectively suppresses basal and inducible NF-kappa B DNA binding activity in cultured rat cortical neurons. Immunoprecipitation-immunoblot analyses using antibodies against HNE-conjugated proteins and p50 and p65 NF-kappa B subunits indicate that HNE does not directly modify NF-kappa B proteins. Moreover, HNE did not affect NF-kappa B DNA-binding activity when added directly to cytosolic extracts, suggesting that HNE inhibits an upstream component of the NF-kappa B signaling pathway. Inhibition of the survival-promoting NF-kappa B signaling pathway by HNE may contribute to neuronal death under conditions in which membrane lipid peroxidation occurs. JF - Brain research. Molecular brain research AU - Camandola, S AU - Poli, G AU - Mattson, M P AD - Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center 4F02, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2000/12/28/ PY - 2000 DA - 2000 Dec 28 SP - 53 EP - 60 VL - 85 IS - 1-2 SN - 0169-328X, 0169-328X KW - Aldehydes KW - 0 KW - Cysteine Proteinase Inhibitors KW - Enzyme Inhibitors KW - NF-kappa B KW - Protein Synthesis Inhibitors KW - Transcription Factor AP-1 KW - pervanadate KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Vanadates KW - 3WHH0066W5 KW - Cycloheximide KW - 98600C0908 KW - 4-hydroxy-2-nonenal KW - K1CVM13F96 KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Cerebral Cortex -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - Vanadates -- pharmacology KW - Apoptosis -- physiology KW - Rats KW - Protein Synthesis Inhibitors -- pharmacology KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Nerve Degeneration -- metabolism KW - Cycloheximide -- pharmacology KW - Apoptosis -- drug effects KW - Okadaic Acid -- pharmacology KW - Stroke -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Alzheimer Disease -- metabolism KW - Cell Survival -- physiology KW - Cysteine Proteinase Inhibitors -- pharmacology KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Neurons -- cytology KW - Lipid Peroxidation -- physiology KW - Aldehydes -- pharmacology KW - NF-kappa B -- metabolism KW - NF-kappa B -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72538181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research.+Molecular+brain+research&rft.atitle=The+lipid+peroxidation+product+4-hydroxy-2%2C3-nonenal+inhibits+constitutive+and+inducible+activity+of+nuclear+factor+kappa+B+in+neurons.&rft.au=Camandola%2C+S%3BPoli%2C+G%3BMattson%2C+M+P&rft.aulast=Camandola&rft.aufirst=S&rft.date=2000-12-28&rft.volume=85&rft.issue=1-2&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Brain+research.+Molecular+brain+research&rft.issn=0169328X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monomer-dimer equilibrium of normal and modified beta A3-crystallins: experimental determination and molecular modeling. AN - 72466136; 11123905 AB - Beta- and gamma-crystallins are major protein constituents of the mammalian lens, where their stability and association into higher order complexes are critical for clarity and refraction. Two regions of the betagamma-crystallins have been suggested to modulate protein association, namely, the flexible N-terminal extensions and the intramolecular domain interfaces. The oligomeric state of wild-type recombinant murine betaA3-crystallin (rbetaA3) was compared to that of modified betaA3-crystallins with either an N-terminal deletion of residues 1 to 29 (rbetaA3tr) or with residues 114 to 123 of the interdomain linker replaced with the analogous linker from murine gammaB-crystallin (rbetaA3cp). All three proteins exhibited reversible monomer-dimer formation. The modifications to the N-terminus and domain linker resulted in tighter dimer formation as compared to wild-type protein as indicated by disassociation constants determined by sedimentation equilibrium: 6.62 x 10(-6) M (rbetaA3), 0.86 x 10(-6) M (rbetaA3cp), and 1.83 x 10(-7) M (rbetaA3tr). Homology modeling of betaA3-crystallins and solvation energy calculations also predicted tighter binding of the modified crystallins consistent with the centrifugation results. The findings suggest that under physiological conditions betaA3 crystallin exists in a dynamic equilibrium between monomeric and dimeric protein and that modification, especially to the N-terminal extension, can promote self-association. JF - Biochemistry AU - Sergeev, Y V AU - Wingfield, P T AU - Hejtmancik, J F AD - National Eye Institute and National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20982, USA. sergeev@helix.nih.gov Y1 - 2000/12/26/ PY - 2000 DA - 2000 Dec 26 SP - 15799 EP - 15806 VL - 39 IS - 51 SN - 0006-2960, 0006-2960 KW - Cryba1 protein, mouse KW - 0 KW - Crystallins KW - Recombinant Proteins KW - Solvents KW - Index Medicus KW - Animals KW - Computer Simulation KW - Dimerization KW - Amino Acid Sequence KW - Mice KW - Ultracentrifugation KW - Mutagenesis, Site-Directed KW - Cattle KW - Sequence Alignment KW - Chromatography, Gel KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Protein Binding -- genetics KW - Recombinant Proteins -- chemistry KW - Sequence Homology, Amino Acid KW - Protein Conformation KW - Models, Molecular KW - Crystallins -- chemistry KW - Crystallins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72466136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Monomer-dimer+equilibrium+of+normal+and+modified+beta+A3-crystallins%3A+experimental+determination+and+molecular+modeling.&rft.au=Sergeev%2C+Y+V%3BWingfield%2C+P+T%3BHejtmancik%2C+J+F&rft.aulast=Sergeev&rft.aufirst=Y&rft.date=2000-12-26&rft.volume=39&rft.issue=51&rft.spage=15799&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Novel Membrane Anchor Function for the N-terminal Amphipathic Sequence of the Signal-transducing Protein IIA super(Glucose) of the Escherichia coli Phosphotransferase System AN - 17735785; 4798386 AB - Enzyme IIA super(Glucose) (IIA super(Glc)) is a signal-transducing protein in the phosphotransferase system of Escherichia coli. Structural studies of free IIA super(Glc) and the HPr-IIA super(Glc) complex have shown that IIA super(Glc) comprises a globular beta -sheet sandwich core (residues 19-168) and a disordered N-terminal tail (residues 1-18). Although the presence of the N-terminal tail is not required for IIA super(Glc) to accept a phosphorus from the histidine phosphocarrier protein HPr, its presence is essential for effective phosphotransfer from IIA super(Glc) to the membrane-bound IIBC super(Glc). The sequence of the N-terminal tail suggests that it has the potential to form an amphipathic helix. Using CD, we demonstrate that a peptide, corresponding to the N-terminal 18 residues of IIA super(Glc), adopts a helical conformation in the presence of either the anionic lipid phosphatidylglycerol or a mixture of anionic E. coli lipids phosphatidylglycerol (25%) and phosphatidylethanolamine (75%). The peptide, however, is in a random coil state in the presence of the zwitterionic lipid phosphatidylcholine, indicating that electrostatic interactions play a role in the binding of the lipid to the peptide. In addition, we show that intact IIA super(Glc) also interacts with anionic lipids, resulting in an increase in helicity, which can be directly attributed to the N-terminal segment. From these data we propose that IIA super(Glc) comprises two functional domains: a folded domain containing the active site and capable of weakly interacting with the peripheral IIB domain of the membrane protein IIBC super(Glc); and the N-terminal tail, which interacts with the negatively charged E. coli membrane, thereby stabilizing the complex of IIA super(Glc) with IIBC super(Glc). This stabilization is essential for the final step of the phosphoryl transfer cascade in the glucose transport pathway. JF - Journal of Biological Chemistry AU - Wang, G AU - Peterkofsky, A AU - Clore, G M AD - Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0510, clore@speck.niddk.nih.gov Y1 - 2000/12/22/ PY - 2000 DA - 2000 Dec 22 SP - 39811 EP - 39814 VL - 275 IS - 51 SN - 0021-9258, 0021-9258 KW - Enzyme IIA super(Glucose) KW - electrostatic properties KW - phosphotransferase KW - Microbiology Abstracts B: Bacteriology KW - Enzyme IIA@@uGlucose@ KW - Escherichia coli KW - Signal transduction KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17735785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=A+Novel+Membrane+Anchor+Function+for+the+N-terminal+Amphipathic+Sequence+of+the+Signal-transducing+Protein+IIA+super%28Glucose%29+of+the+Escherichia+coli+Phosphotransferase+System&rft.au=Wang%2C+G%3BPeterkofsky%2C+A%3BClore%2C+G+M&rft.aulast=Wang&rft.aufirst=G&rft.date=2000-12-22&rft.volume=275&rft.issue=51&rft.spage=39811&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Signal transduction ER - TY - JOUR T1 - The genetic toxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4, 4'-tetrachloroazoxybenzene: discordance between acute mouse bone marrow and subchronic mouse peripheral blood micronucleus test results. AN - 72478009; 11113707 AB - 3,3',4,4'-Tetrachloroazobenzene (TCAB) and 3,3',4, 4'-tetrachloroazoxybenzene (TCAOB) are dioxin-like chemicals that were investigated for toxicity in 13-week gavage studies in male and female B6C3F(1) mice and F344N rats by the National Toxicology Program. As part of the comprehensive toxicological investigation of these chemicals, peripheral blood smears from mice treated 5 days per week for 13 weeks with 0.1-30mg/kg/day TCAB or TCAOB were analyzed for the frequency of micronucleated (MN) normochromatic erythrocytes (NCE). Both chemicals produced significant increases in MN-NCE in male and female mice. In contrast to these positive results in subchronic exposure studies, no significant increases were seen in acute bone marrow MN tests in male mice administered three daily injections of 50-200mg/kg/day TCAB and TCAOB. The results with TCAB and TCAOB suggest that the routine integration of MN tests with subchronic toxicity studies may allow detection of mutagenic activity for some chemicals that fail to elicit responses in short-term, high dose tests. In addition, the integration of mutagenicity tests into general toxicity tests reduces the use of laboratory animals and the cost of the testing. JF - Mutation research AU - Witt, K L AU - Zeiger, E AU - Tice, R R AU - van Birgelen, A P AD - ILS Inc., P.O. Box 13501, Research Triangle Park, NC 27709, USA. witt@niehs.nih.gov Y1 - 2000/12/20/ PY - 2000 DA - 2000 Dec 20 SP - 147 EP - 154 VL - 472 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Azo Compounds KW - 0 KW - Chlorobenzenes KW - Mutagens KW - 3,4,3',4'-tetrachloroazobenzene KW - 14047-09-7 KW - 3,4,3',4'-tetrachloroazoxybenzene KW - 21232-47-3 KW - Index Medicus KW - Rats KW - Mice, Inbred Strains KW - Erythrocytes -- drug effects KW - Animals KW - Rats, Inbred F344 KW - Micronucleus Tests KW - Reproducibility of Results KW - Sex Characteristics KW - Mutagens -- toxicity KW - Mice KW - Male KW - Female KW - Bone Marrow Cells -- drug effects KW - Micronuclei, Chromosome-Defective -- drug effects KW - Chlorobenzenes -- toxicity KW - Mutagenicity Tests KW - Azo Compounds -- toxicity KW - Bone Marrow Cells -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72478009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+genetic+toxicity+of+3%2C3%27%2C4%2C4%27-tetrachloroazobenzene+and+3%2C3%27%2C4%2C+4%27-tetrachloroazoxybenzene%3A+discordance+between+acute+mouse+bone+marrow+and+subchronic+mouse+peripheral+blood+micronucleus+test+results.&rft.au=Witt%2C+K+L%3BZeiger%2C+E%3BTice%2C+R+R%3Bvan+Birgelen%2C+A+P&rft.aulast=Witt&rft.aufirst=K&rft.date=2000-12-20&rft.volume=472&rft.issue=1-2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-26 N1 - Date created - 2001-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ets and retroviruses - transduction and activation of members of the Ets oncogene family in viral oncogenesis. AN - 72565794; 11175363 AB - Studies of retroviral-induced oncogenesis in animal systems led to the initial discovery of viral oncogenes and their cellular homologs, and provided critical insights into their role in the neoplastic process. V-ets, the founding member of the ETS oncogene family, was originally identified as part of the fusion oncogene encoded by the avian acute leukemia virus E26 and subsequent analysis of virus induced leukemias led to the initial isolation of two other members of the ETS gene family. PU.1 was identified as a target of insertional activation in the majority of tumors induced by the murine Spleen Focus Forming virus (SFFV), while fli-1 proved to be the target of Friend murine leukemia virus (F-MuLV) in F-MuLV induced erythroleukemia, as well as that of the 10A1 and Graffi viruses. The common features of the erythroid and myeloid diseases induced by these viruses provided the initial demonstration that these and other members of the ETS family play important roles in hematopoietic development as well as disease. This review provides an overview of the role of ETS genes in retrovirally induced neoplasia, their possible mechanisms of action, and how these viral studies relate to current knowledge of the functions of these genes in hematopoiesis. JF - Oncogene AU - Blair, D G AU - Athanasiou, M AD - National Cancer Institute, Division of Basic Science, Basic Research Laboratory, Oncogene Mechanisms Section, Frederick, Maryland, MD 21702-1207, USA. Y1 - 2000/12/18/ PY - 2000 DA - 2000 Dec 18 SP - 6472 EP - 6481 VL - 19 IS - 55 SN - 0950-9232, 0950-9232 KW - DNA-Binding Proteins KW - 0 KW - Fli1 protein, mouse KW - Proto-Oncogene Protein c-fli-1 KW - Proto-Oncogene Proteins KW - Trans-Activators KW - Index Medicus KW - 3T3 Cells KW - Animals KW - Avian Myeloblastosis Virus -- physiology KW - Leukemia Virus, Murine -- genetics KW - Humans KW - DNA-Binding Proteins -- genetics KW - Mice KW - Fibroblasts -- metabolism KW - Leukemia Virus, Murine -- physiology KW - Chickens KW - Alpharetrovirus -- genetics KW - Trans-Activators -- genetics KW - Avian Myeloblastosis Virus -- genetics KW - Proviruses -- genetics KW - Alpharetrovirus -- physiology KW - Spleen Focus-Forming Viruses -- physiology KW - DNA-Binding Proteins -- physiology KW - Trans-Activators -- physiology KW - Mutagenesis, Insertional KW - Hematopoiesis -- genetics KW - Spleen Focus-Forming Viruses -- genetics KW - Gene Expression Regulation, Neoplastic KW - Oncogenes KW - Gene Expression Regulation, Viral KW - Multigene Family KW - Retroviridae -- physiology KW - Cell Transformation, Viral -- genetics KW - Retroviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72565794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Ets+and+retroviruses+-+transduction+and+activation+of+members+of+the+Ets+oncogene+family+in+viral+oncogenesis.&rft.au=Blair%2C+D+G%3BAthanasiou%2C+M&rft.aulast=Blair&rft.aufirst=D&rft.date=2000-12-18&rft.volume=19&rft.issue=55&rft.spage=6472&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure-Function Modeling of the Interactions of N-Alkyl-N-hydroxyanilines with Rat Hepatic Aryl Sulfotransferase IV AN - 17756160; 4821001 AB - Although previous investigations have clearly shown that N-hydroxy arylamines and N-hydroxy heterocyclic amines are substrates for sulfotransferases, relatively little is known about which structural features of the N-hydroxy arylamines are important for sulfation to occur. The purpose of this investigation was to determine the extent to which secondary N-alkyl-N-hydroxy arylamines interact with aryl sulfotransferase (AST) IV (also known as tyrosine-ester sulfotransferase or ST1A1) and to evaluate these interactions using molecular modeling techniques. AST IV is a major cytosolic sulfotransferase in the rat, and it catalyzes the sulfation of various phenols, benzylic alcohols, arylhydroxamic acids, oximes, and primary N-hydroxy arylamines. In this study, three secondary N-hydroxy arylamines, N-hydroxy-N-methylaniline, N-ethyl-N-hydroxyaniline, and N-hydroxy-N-n-propylaniline, were found to be substrates for the purified rat hepatic AST IV. However, when the N-alkyl substituent was an n-butyl group (i.e., N-n-butyl-N-hydroxyaniline), the interaction with the enzyme changed from that of a substrate to competitive inhibition. This change in specificity was further explored through the construction and use of a model for AST IV based on mouse estrogen sulfotransferase, an enzyme whose crystal structure has been previously determined to high resolution. Molecular modeling techniques were used to dock each of the above N-hydroxy arylamines into the active site of the homology model of AST IV and determine optimum ligand geometries. The results of these experiments indicated that steric constraints on the orientation of binding of secondary N-alkyl-N-hydroxy arylamines at the active site of AST IV play a significant role in determining the nature of the interaction of the enzyme with these compounds. JF - Chemical Research in Toxicology AU - King, R S AU - Sharma, V AU - Pedersen, L C AU - Kakuta, Yoshimitsu AU - Negishi, Masahiko AU - Duffel, M W AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA Y1 - 2000/12/18/ PY - 2000 DA - 2000 Dec 18 SP - 1251 EP - 1258 VL - 13 IS - 12 SN - 0893-228X, 0893-228X KW - rats KW - N-Alkyl-N-hydroxyanilines KW - aryl sulfotransferase IV KW - Toxicology Abstracts KW - Liver KW - Structure-activity relationships KW - X 24155:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17756160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Structure-Function+Modeling+of+the+Interactions+of+N-Alkyl-N-hydroxyanilines+with+Rat+Hepatic+Aryl+Sulfotransferase+IV&rft.au=King%2C+R+S%3BSharma%2C+V%3BPedersen%2C+L+C%3BKakuta%2C+Yoshimitsu%3BNegishi%2C+Masahiko%3BDuffel%2C+M+W&rft.aulast=King&rft.aufirst=R&rft.date=2000-12-18&rft.volume=13&rft.issue=12&rft.spage=1251&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Structure-activity relationships; Liver ER - TY - JOUR T1 - Expression and localization of prestin and the sugar transporter GLUT-5 during development of electromotility in cochlear outer hair cells. AN - 85291388; pmid-11125015 AB - Electromotility, i.e., the ability of cochlear outer hair cells (OHCs) to contract and elongate at acoustic frequencies, is presumed to depend on the voltage-driven conformational changes of "motor" proteins present in the OHC lateral plasma membrane. Recently, two membrane proteins have been proposed as candidates for the OHC motor. A sugar transporter, GLUT-5, was proposed based on its localization in the OHCs and on the observation that sugar transport alters the voltage sensitivity of the OHC motor mechanism. Another candidate, "prestin," was identified from a subtracted OHC cDNA library and shown to impart voltage-driven shape changes to transfected cultured cells. We used antibodies specific for these two proteins to show that they are highly expressed in the lateral membrane of OHCs. We also compared the postnatal expression patterns of these proteins with the development of electromotility in OHCs of the apical turn of the rat organ of Corti. The patch-clamp recording of transient charge movement associated with electromotility indicates that half of the maximal expression of the motor protein occurs at postnatal day 9. Prestin incorporation in the plasma membrane begins from postnatal day 0 and increases progressively in a time course coinciding with that of electromotility. GLUT-5 is not incorporated into the lateral plasma membrane of apical OHCs until postnatal day 15. Our results suggest that, although GLUT-5 may be involved in the control of electromotility, prestin is likely to be a fundamental component of the OHC membrane motor mechanism. JF - The Journal of Neuroscience AU - Belyantseva, I A AU - Adler, H J AU - Curi, R AU - Frolenkov, G I AU - Kachar Bechara AD - Section on Structural Cell Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA.; National Institute on Deafness and Other Communication Disorders Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 1 VL - 20 IS - 24 SN - 0270-6474, 0270-6474 KW - Cochlea KW - Animals KW - Cell Size KW - In Vitro KW - Aging KW - Cell Differentiation KW - Electrophysiology KW - Organ of Corti KW - Research Support, U.S. Gov't, P.H.S. KW - Research Support, Non-U.S. Gov't KW - Rats KW - Rats, Sprague-Dawley KW - Patch-Clamp Techniques KW - Hair Cells, Outer KW - Molecular Motors KW - Cell Membrane KW - Proteins KW - Immunohistochemistry KW - Fluorescent Antibody Technique KW - Monosaccharide Transport Proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85291388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Expression+and+localization+of+prestin+and+the+sugar+transporter+GLUT-5+during+development+of+electromotility+in+cochlear+outer+hair+cells.&rft.au=Belyantseva%2C+I+A%3BAdler%2C+H+J%3BCuri%2C+R%3BFrolenkov%2C+G+I%3BKachar+Bechara&rft.aulast=Belyantseva&rft.aufirst=I&rft.date=2000-12-15&rft.volume=20&rft.issue=24&rft.spage=RC116&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Estrogen promotes mammary tumor development in C3(1)/SV40 large T-antigen transgenic mice: paradoxical loss of estrogen receptoralpha expression during tumor progression. AN - 72537191; 11156389 AB - Although several lines of epidemiological evidence suggest that estrogen exposure influences the incidence of breast cancer development, the mechanisms by which estrogen may stimulate the formation of breast cancer remain poorly understood. We have explored how alterations in estrogen exposure can influence the development of mammary cancer in the C3(1)/T(AG) transgenic model, where estrogen levels and estrogen receptor alpha (ERalpha) expression do not appear to modify the level of transgene expression. The C3(1)/T(AG) transgene becomes transcriptionally active in mammary ductal target cells at 3 weeks of age after the estrogen-induced differentiation of the mammary epithelial anlage to the ductal outgrowth stage. Complete maturation of the mammary ductal tree, however, is not required for cancer development because tumors arise in animals where ductal branching and terminal end bud formation have been prematurely arrested by ovariectomy. Mammary tumorigenesis in this model is promoted by increased estrogen exposure with the development of significantly more mammary intraepithelial neoplastic lesions and carcinomas associated with accelerated malignant conversion. The promotion of mammary tumors in this model appears to occur through an estrogen-induced proliferation and increase in the number of available target cells for transformation at the terminal ductal lobular units, as has been postulated to occur in women who receive hormone replacement therapy and/or by additional molecular mechanisms. We show, for the first time in a transgenic mouse model, that mammary tumor progression is associated with the loss of ERalpha expression, as has been often observed in human breast cancers with important clinical significance. Estrogen signaling may, therefore, serve different functions, depending upon the stage of tumorigenesis. ERbeta expression is up-regulated during tumor progression, although the functional significance of this remains to be determined. JF - Cancer research AU - Yoshidome, K AU - Shibata, M A AU - Couldrey, C AU - Korach, K S AU - Green, J E AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, NIH, Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 6901 EP - 6910 VL - 60 IS - 24 SN - 0008-5472, 0008-5472 KW - Antigens, Viral, Tumor KW - 0 KW - Estrogen Receptor alpha KW - Estrogens KW - Receptors, Estrogen KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Disease Progression KW - Mice KW - Tissue Distribution KW - Reverse Transcriptase Polymerase Chain Reaction KW - Blotting, Western KW - Tumor Cells, Cultured KW - Phosphorylation KW - Transfection KW - RNA -- metabolism KW - Time Factors KW - Immunohistochemistry KW - Mutation KW - Female KW - Receptors, Estrogen -- biosynthesis KW - Estrogens -- pharmacology KW - Estrogens -- metabolism KW - Antigens, Viral, Tumor -- genetics KW - Mammary Neoplasms, Experimental -- genetics KW - Mice, Transgenic KW - Mammary Neoplasms, Experimental -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72537191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Estrogen+promotes+mammary+tumor+development+in+C3%281%29%2FSV40+large+T-antigen+transgenic+mice%3A+paradoxical+loss+of+estrogen+receptoralpha+expression+during+tumor+progression.&rft.au=Yoshidome%2C+K%3BShibata%2C+M+A%3BCouldrey%2C+C%3BKorach%2C+K+S%3BGreen%2C+J+E&rft.aulast=Yoshidome&rft.aufirst=K&rft.date=2000-12-15&rft.volume=60&rft.issue=24&rft.spage=6901&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2001-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2. AN - 72488574; 11120846 AB - LMB-2 (anti-Tac(Fv)-PE38) is a recombinant immunotoxin composed of the Fv fragment of the anti-Tac Ab fused to a 38-kDa form of Pseudomonas: exotoxin A. Recent clinical trials showed that LMB-2 is a promising agent for the treatment of patients with Tac-positive leukemia or lymphoma. One major side effect that needs to be overcome is nonspecific liver toxicity. In the current study, we have analyzed the mechanism of this toxicity using a mouse model. Mice that were injected with a lethal dose of LMB-2 showed severe hepatic necrosis. Immunohistochemistry revealed that LMB-2 accumulated in Kupffer cells in the liver, suggesting that the damage to the hepatocytes was indirect. When we examined the effects of LMB-2 on peritoneal macrophages, cells in the same lineage as Kupffer cells, we found that LMB-2 induced the production of TNF-alpha by these cells. Following LMB-2 administration to mice, the levels of TNF-alpha in the liver increased to very high levels, whereas the rise in serum levels was modest. In addition, the LMB-2-induced liver toxicity was blocked by a specific TNF binding protein (TNFsRp55). Liver toxicity was also blocked by indomethacin, which also blocked the rise of TNF-alpha in the liver. Both TNFsRp55 and indomethacin treatment protected mice against a lethal dose of LMB-2. These data indicate that TNF-alpha produced in the liver by Kupffer cells has an important causal role in the nonspecific liver toxicity of LMB-2. These findings have important clinical implications for the use of immunotoxins in the therapy of patients with cancer. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Onda, M AU - Willingham, M AU - Wang, Q C AU - Kreitman, R J AU - Tsutsumi, Y AU - Nagata, S AU - Pastan, I AD - Laboratory of Molecular Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 7150 EP - 7156 VL - 165 IS - 12 SN - 0022-1767, 0022-1767 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Cytokines KW - Exotoxins KW - Immunoglobulin Fragments KW - Immunotoxins KW - Receptors, Tumor Necrosis Factor KW - Receptors, Tumor Necrosis Factor, Type I KW - Recombinant Proteins KW - Tumor Necrosis Factor-alpha KW - immunoglobulin Fv KW - Indomethacin KW - XXE1CET956 KW - Abridged Index Medicus KW - Index Medicus KW - Cytokines -- blood KW - Animals KW - Cytokines -- biosynthesis KW - Macrophages, Peritoneal -- immunology KW - Indomethacin -- pharmacology KW - Tumor Cells, Cultured -- immunology KW - Recombinant Proteins -- metabolism KW - Macrophages, Peritoneal -- metabolism KW - Immunoglobulin Fragments -- metabolism KW - Tumor Cells, Cultured -- pathology KW - Antigens, CD -- pharmacology KW - Immunoglobulin Fragments -- toxicity KW - Recombinant Proteins -- administration & dosage KW - Exotoxins -- administration & dosage KW - Tumor Cells, Cultured -- metabolism KW - Injections, Intravenous KW - Antibodies, Monoclonal -- metabolism KW - Mice KW - Pseudomonas -- immunology KW - Antibodies, Monoclonal -- administration & dosage KW - Recombinant Proteins -- toxicity KW - Antibodies, Monoclonal -- toxicity KW - Immunoglobulin Fragments -- administration & dosage KW - Exotoxins -- metabolism KW - Recombinant Proteins -- immunology KW - Exotoxins -- toxicity KW - Female KW - Liver -- pathology KW - Immunotoxins -- toxicity KW - Liver -- immunology KW - Kupffer Cells -- immunology KW - Liver -- metabolism KW - Kupffer Cells -- metabolism KW - Tumor Necrosis Factor-alpha -- physiology KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Immunotoxins -- metabolism KW - Immunotoxins -- administration & dosage KW - Kupffer Cells -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72488574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Inhibition+of+TNF-alpha+produced+by+Kupffer+cells+protects+against+the+nonspecific+liver+toxicity+of+immunotoxin+anti-Tac%28Fv%29-PE38%2C+LMB-2.&rft.au=Onda%2C+M%3BWillingham%2C+M%3BWang%2C+Q+C%3BKreitman%2C+R+J%3BTsutsumi%2C+Y%3BNagata%2C+S%3BPastan%2C+I&rft.aulast=Onda&rft.aufirst=M&rft.date=2000-12-15&rft.volume=165&rft.issue=12&rft.spage=7150&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. AN - 72487016; 11120818 AB - We have used a recombinant, biotinylated form of the mouse NK cell inhibitory receptor, Ly49A, to visualize the expression of MHC class I (MHC-I) ligands on living lymphoid cells. A panel of murine strains, including MHC congenic lines, was examined. We detected binding of Ly49A to cells expressing H-2D(d), H-2D(k), and H-2D(p) but not to those expressing other MHC molecules. Cells of the MHC-recombinant strain B10.PL (H-2(u)) not only bound Ly49A but also inhibited cytolysis by Ly49A(+) effector cells, consistent with the correlation of in vitro binding and NK cell function. Binding of Ly49A to H-2D(d)-bearing cells of different lymphoid tissues was proportional to the level of H-2D(d) expression and was not related to the lineage of the cells examined. These binding results, interpreted in the context of amino acid sequence comparisons and the recently determined three-dimensional structure of the Ly49A/H-2D(d) complex, suggest a role for amino acid residues at the amino-terminal end of the alpha1 helix of the MHC-I molecule for Ly49A interaction. This view is supported by a marked decrease in affinity of an H-2D(d) mutant, I52 M, for Ly49A. Thus, allelic variation of MHC-I molecules controls measurable affinity for the NK inhibitory receptor Ly49A and explains differences in functional recognition in different mouse strains. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Chung, D H AU - Natarajan, K AU - Boyd, L F AU - Tormo, J AU - Mariuzza, R A AU - Yokoyama, W M AU - Margulies, D H AD - Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 6922 EP - 6932 VL - 165 IS - 12 SN - 0022-1767, 0022-1767 KW - Antigens, Ly KW - 0 KW - Carrier Proteins KW - Epitopes KW - H-2 Antigens KW - Histocompatibility Antigen H-2D KW - Klra1 protein, mouse KW - Lectins, C-Type KW - Ligands KW - Membrane Proteins KW - NK Cell Lectin-Like Receptor Subfamily A KW - Receptors, NK Cell Lectin-Like KW - Abridged Index Medicus KW - Index Medicus KW - Lymph Nodes -- metabolism KW - Animals KW - Mice, Inbred BALB C KW - Mice, Transgenic KW - Lymph Nodes -- cytology KW - Biotinylation KW - Mutagenesis, Site-Directed KW - Epitopes -- analysis KW - Tumor Cells, Cultured KW - Sequence Alignment KW - Lymph Nodes -- chemistry KW - Lymph Nodes -- immunology KW - Solubility KW - Staining and Labeling -- methods KW - Amino Acid Sequence KW - Mice KW - Lymphocyte Subsets -- metabolism KW - Mice, Inbred A KW - Lymphocyte Subsets -- chemistry KW - Mice, Inbred C57BL KW - Lymphocyte Subsets -- immunology KW - H-2 Antigens -- genetics KW - Carrier Proteins -- metabolism KW - Membrane Proteins -- metabolism KW - Carrier Proteins -- analysis KW - Membrane Proteins -- analysis KW - Killer Cells, Natural -- metabolism KW - Killer Cells, Natural -- immunology KW - H-2 Antigens -- analysis KW - Epitope Mapping -- methods KW - H-2 Antigens -- metabolism KW - H-2 Antigens -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72487016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Mapping+the+ligand+of+the+NK+inhibitory+receptor+Ly49A+on+living+cells.&rft.au=Chung%2C+D+H%3BNatarajan%2C+K%3BBoyd%2C+L+F%3BTormo%2C+J%3BMariuzza%2C+R+A%3BYokoyama%2C+W+M%3BMargulies%2C+D+H&rft.aulast=Chung&rft.aufirst=D&rft.date=2000-12-15&rft.volume=165&rft.issue=12&rft.spage=6922&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of smoking during antipsychotic withdrawal in patients with chronic schizophrenia. AN - 72478873; 11120424 AB - A number of studies have shown that patients with schizophrenia smoke more than other psychiatric patients and more than the general population. Also, medicated schizophrenics who smoke present more positive symptoms of schizophrenia than non-smokers. The objective of the present study was to assess the effect of smoking on ratings of psychopathology for 30 days following discontinuation of antipsychotic medication. The subjects were 101 treatment-resistant patients with schizophrenia who had been admitted to the inpatient service of Neuroscience Research Hospital (NRH), National Institute of Mental Health, between 1982 and 1994 to undergo studies involving discontinuation of antipsychotic medication. Patients were rated independently on a daily basis on the 22-item Psychiatric Symptom Assessment Scale (PSAS), an extended version of the Brief Psychiatric Rating Scale (BPRS). At baseline, ratings for Verbal Positive, Paranoia and Loss of Function were higher in smokers (n=65) than non-smokers (n=36), but a statistically significant difference was observed only for the Verbal Positive cluster. Analysis by gender revealed that male non-smokers had the lowest psychopathology ratings at baseline. There were no differences in Anxiety/depression, Behavior Positive, Deficit Symptoms or Mannerisms (a measure for abnormal involuntary movements). Following medication discontinuation, repeated-measure analysis demonstrated a 'time' effect for all the variables studied and a 'group' (smokers vs. non-smokers) effect for Verbal Positive, Paranoia, and Loss of Function. Post-hoc comparisons at individual time points showed significantly higher ratings for smokers at week 1 for Paranoia. No differences were observed at later time points. In conclusion, at baseline, smokers had more positive symptoms and were apparently more functionally impaired than non-smokers. This difference was no longer evident after a 30 day medication discontinuation period. JF - Schizophrenia research AU - Apud, J A AU - Egan, M F AU - Wyatt, R J AD - Neuroscience Center at St. Elizabeth's, Neuropsychiatry Branch, National Institute of Mental Health, 2700 Martin Luther King, Jr. Ave., SE, Washington, DC 20032, USA. apudj@intra.nimh.nih.gov Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 119 EP - 127 VL - 46 IS - 2-3 SN - 0920-9964, 0920-9964 KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Humans KW - Adult KW - Retrospective Studies KW - Chronic Disease KW - Male KW - Female KW - Mental Disorders -- diagnosis KW - Substance Withdrawal Syndrome -- etiology KW - Substance Withdrawal Syndrome -- diagnosis KW - Mental Disorders -- epidemiology KW - Smoking -- adverse effects KW - Schizophrenia -- drug therapy KW - Mental Disorders -- etiology KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72478873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Effects+of+smoking+during+antipsychotic+withdrawal+in+patients+with+chronic+schizophrenia.&rft.au=Apud%2C+J+A%3BEgan%2C+M+F%3BWyatt%2C+R+J&rft.aulast=Apud&rft.aufirst=J&rft.date=2000-12-15&rft.volume=46&rft.issue=2-3&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-02 N1 - Date created - 2001-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. AN - 72476659; 11137053 AB - High (10-20 Hz) and low frequency (1-5 Hz) repetitive transcranial magnetic stimulation (rTMS) have been explored for possible therapeutic effects in the treatment of neuropsychiatric disorders. As part of a double-blind, placebo-controlled, crossover study evaluating the antidepressant effect of daily rTMS over the left prefrontal cortex, we evaluated changes in absolute regional cerebral blood flow (rCBF) after treatment with 1- and 20-Hz rTMS. Based on preclinical data, we postulated that high frequency rTMS would increase and low frequency rTMS would decrease flow in frontal and related subcortical circuits. Ten medication-free, adult patients with major depression (eight unipolar and two bipolar) were serially imaged using (15)O water and positron emission tomography to measure rCBF. Each patient was scanned at baseline and 72 hours after 10 daily treatments with 20-Hz rTMS and 10 daily treatments with 1 Hz rTMS given in a randomized order. TMS was administered over the left prefrontal cortex at 100% of motor threshold (MT). Significant changes in rCBF from pretreatment baseline were determined by paired t test. Twenty-hertz rTMS over the left prefrontal cortex was associated only with increases in rCBF. Significant increases in rCBF across the group of all 10 patients were located in the prefrontal cortex (L > R), the cingulate gyrus (L >> R), and the left amygdala, as well as bilateral insula, basal ganglia, uncus, hippocampus, parahippocampus, thalamus, and cerebellum. In contrast, 1-Hz rTMS was associated only with decreases in rCBF. Significant decreases in flow were noted in small areas of the right prefrontal cortex, left medial temporal cortex, left basal ganglia, and left amygdala. The changes in mood following the two rTMS frequencies were inversely related (r = -.78, p <.005, n = 10) such that individuals who improved with one frequency worsened with the other. These data indicate that 2 weeks of daily 20-Hz rTMS over the left prefrontal cortex at 100% MT induce persistent increases in rCBF in bilateral frontal, limbic, and paralimbic regions implicated in depression, whereas 1-Hz rTMS produces more circumscribed decreases (including in the left amygdala). These data demonstrate frequency-dependent, opposite effects of high and low frequency rTMS on local and distant regional brain activity that may have important implications for clinical therapeutics in various neuropsychiatric disorders. JF - Biological psychiatry AU - Speer, A M AU - Kimbrell, T A AU - Wassermann, E M AU - D Repella, J AU - Willis, M W AU - Herscovitch, P AU - Post, R M AD - Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20895, USA. Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 1133 EP - 1141 VL - 48 IS - 12 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Magnetoencephalography KW - Double-Blind Method KW - Humans KW - Prefrontal Cortex -- blood supply KW - Dose-Response Relationship, Radiation KW - Brain Mapping KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Tomography, Emission-Computed KW - Bipolar Disorder -- therapy KW - Middle Aged KW - Female KW - Male KW - Brain -- physiopathology KW - Depressive Disorder, Major -- diagnostic imaging KW - Brain -- pathology KW - Brain -- blood supply KW - Depressive Disorder, Major -- therapy KW - Cerebrovascular Circulation KW - Brain -- diagnostic imaging KW - Electromagnetic Phenomena KW - Electric Stimulation Therapy -- methods KW - Depressive Disorder, Major -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72476659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Opposite+effects+of+high+and+low+frequency+rTMS+on+regional+brain+activity+in+depressed+patients.&rft.au=Speer%2C+A+M%3BKimbrell%2C+T+A%3BWassermann%2C+E+M%3BD+Repella%2C+J%3BWillis%2C+M+W%3BHerscovitch%2C+P%3BPost%2C+R+M&rft.aulast=Speer&rft.aufirst=A&rft.date=2000-12-15&rft.volume=48&rft.issue=12&rft.spage=1133&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. AN - 72475562; 11125013 AB - Coadministration of kappa-opioid receptor agonists (kappa-agonists) with cocaine prevents alterations in dialysate dopamine (DA) concentration in the nucleus accumbens (Acb) that occur during abstinence from repeated cocaine treatment. Quantitative microdialysis was used to determine the mechanism producing these effects. Rats were injected with cocaine (20 mg/kg, i.p.), or saline, and the selective kappa-agonist U-69593 (0.32 mg/kg, s.c.), or vehicle, once daily for 5 d. Extracellular DA concentration (DA(ext)) and extraction fraction (E(d)), an indirect measure of DA uptake, were determined 3 d later. Repeated cocaine treatment increased E(d), whereas repeated U-69593 treatment decreased E(d), relative to controls. Coadministration of both drugs yielded intermediate E(d) values not different from controls. In vitro DA uptake assays confirmed that repeated U-69593 treatment produces a dose-related, region-specific decrease in DA uptake and showed that acute U-69593 administration increases DA uptake in a nor-binaltorphimine reversible manner. Repeated U-69593 also led to a decrease in [(125)I]RTI-55 binding to the DA transporter (DAT), but did not decrease total DAT protein. These results demonstrate that kappa-opioid receptor activation modulates DA uptake in the Acb in a manner opposite to that of cocaine: repeated U-69593 administration decreases the basal rate of DA uptake, and acute U-69593 administration transiently increases DA uptake. kappa-agonist treatment also alters DAT function. The action of kappa-agonists on DA uptake or DAT binding, or both, may be the mechanism(s) mediating the previously reported "cocaine-antagonist" effect of kappa-opioid receptor agonists. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Thompson, A C AU - Zapata, A AU - Justice, J B AU - Vaughan, R A AU - Sharpe, L G AU - Shippenberg, T S AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. act2@buffalo.edu Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 9333 EP - 9340 VL - 20 IS - 24 KW - Benzeneacetamides KW - 0 KW - Carrier Proteins KW - Dopamine Plasma Membrane Transport Proteins KW - Iodine Radioisotopes KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Pyrrolidines KW - Receptors, Opioid, kappa KW - Slc6a3 protein, rat KW - norbinaltorphimine KW - 36OOQ86QM1 KW - Naltrexone KW - 5S6W795CQM KW - Cocaine KW - I5Y540LHVR KW - U 69593 KW - J5S4K6TKTG KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Injections, Intraperitoneal KW - Pyrrolidines -- administration & dosage KW - Animals KW - Analysis of Variance KW - Drug Administration Schedule KW - Carrier Proteins -- metabolism KW - Extracellular Space -- chemistry KW - Corpus Striatum -- metabolism KW - Linear Models KW - Autoradiography KW - Rats KW - Microdialysis KW - Rats, Sprague-Dawley KW - Corpus Striatum -- chemistry KW - Extracellular Space -- metabolism KW - Injections, Subcutaneous KW - Drug Antagonism KW - Male KW - Naltrexone -- administration & dosage KW - Nucleus Accumbens -- chemistry KW - Nucleus Accumbens -- drug effects KW - Naltrexone -- analogs & derivatives KW - Receptors, Opioid, kappa -- metabolism KW - Cocaine -- administration & dosage KW - Receptors, Opioid, kappa -- agonists KW - Dopamine -- pharmacokinetics KW - Nucleus Accumbens -- metabolism KW - Dopamine -- analysis KW - Cocaine -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72475562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Kappa-opioid+receptor+activation+modifies+dopamine+uptake+in+the+nucleus+accumbens+and+opposes+the+effects+of+cocaine.&rft.au=Thompson%2C+A+C%3BZapata%2C+A%3BJustice%2C+J+B%3BVaughan%2C+R+A%3BSharpe%2C+L+G%3BShippenberg%2C+T+S&rft.aulast=Thompson&rft.aufirst=A&rft.date=2000-12-15&rft.volume=20&rft.issue=24&rft.spage=9333&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Requirement for ERK activation in cisplatin-induced apoptosis. AN - 72463660; 10993883 AB - Cisplatin activates multiple signal transduction pathways involved in coordinating cellular responses to stress. Here we demonstrate a requirement for extracellular signal-regulated protein kinase (ERK), a member of the mitogen-activated protein kinase family in mediating cisplatin-induced apoptosis of human cervical carcinoma HeLa cells. Cisplatin treatment resulted in dose- and time- dependent activation of ERK. That elevated ERK activity contributed to cell death by cisplatin was supported by several observations: 1) PD98059 and U0126, chemical inhibitors of the MEK/ERK signaling pathway, prevented apoptosis; 2) pretreatment of cells with TPA, an activator of the ERK pathway, enhanced their sensitivity to cisplatin; 3) suramin, a growth factor receptor antagonist that greatly suppressed ERK activation, likewise inhibited cisplatin-induced apoptosis; and, finally, 4) HeLa cell variants selected for cisplatin resistance showed reduced activation of ERK following cisplatin treatment. Cisplatin-induced apoptosis was associated with cytochrome c release and subsequent caspase-3 activation, both of which could be prevented by treatment with the MEK inhibitors. However, the caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone protected HeLa cells against apoptosis without affecting ERK activation. Taken together, our findings suggest that ERK activation plays an active role in mediating cisplatin-induced apoptosis of HeLa cells and functions upstream of caspase activation to initiate the apoptotic signal. JF - The Journal of biological chemistry AU - Wang, X AU - Martindale, J L AU - Holbrook, N J AD - Cell Stress and Aging Section, Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224-6825, USA. Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 39435 EP - 39443 VL - 275 IS - 50 SN - 0021-9258, 0021-9258 KW - 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one KW - 0 KW - Amino Acid Chloromethyl Ketones KW - Antineoplastic Agents KW - Butadienes KW - Cysteine Proteinase Inhibitors KW - Cytochrome c Group KW - Enzyme Inhibitors KW - Flavonoids KW - Indoles KW - Nitriles KW - U 0126 KW - benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone KW - DAPI KW - 47165-04-8 KW - Suramin KW - 6032D45BEM KW - MAP2K2 protein, human KW - EC 2.7.1.- KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase 1 KW - EC 2.7.12.2 KW - MAP Kinase Kinase 2 KW - MAP2K1 protein, human KW - Mitogen-Activated Protein Kinase Kinases KW - CASP3 protein, human KW - EC 3.4.22.- KW - Caspase 3 KW - Caspases KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Humans KW - Protein-Serine-Threonine Kinases -- antagonists & inhibitors KW - Suramin -- pharmacology KW - Models, Biological KW - Caspases -- metabolism KW - Cysteine Proteinase Inhibitors -- pharmacology KW - Cell Survival -- drug effects KW - Flavonoids -- pharmacology KW - Cytochrome c Group -- metabolism KW - Time Factors KW - Signal Transduction KW - Nitriles -- pharmacology KW - Enzyme Activation KW - Dose-Response Relationship, Drug KW - HeLa Cells KW - Protein-Tyrosine Kinases -- antagonists & inhibitors KW - Blotting, Western KW - Butadienes -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors KW - Indoles -- pharmacology KW - Amino Acid Chloromethyl Ketones -- pharmacology KW - Cell Line KW - Mitogen-Activated Protein Kinases -- metabolism KW - Apoptosis -- drug effects KW - Cisplatin -- pharmacology KW - Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72463660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Requirement+for+ERK+activation+in+cisplatin-induced+apoptosis.&rft.au=Wang%2C+X%3BMartindale%2C+J+L%3BHolbrook%2C+N+J&rft.aulast=Wang&rft.aufirst=X&rft.date=2000-12-15&rft.volume=275&rft.issue=50&rft.spage=39435&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stability of DNA triplexes on shuttle vector plasmids in the replication pool in mammalian cells. AN - 72459285; 10993885 AB - Triple helix-forming oligonucleotides may be useful as gene-targeting reagents in vivo, for applications such as gene knockout. One important property of these complexes is their often remarkable stability, as demonstrated in solution and in cells following transfection. Although encouraging, these measurements do not necessarily report triplex stability in cellular compartments that support DNA functions such as replication and mutagenesis. We have devised a shuttle vector plasmid assay that reports the stability of triplexes on DNA that undergoes replication and mutagenesis. The assay is based on plasmids with novel variant supF tRNA genes containing embedded sequences for triplex formation and psoralen cross-linking. Triple helix-forming oligonucleotides were linked to psoralen and used to form triplexes on the plasmids. At various times after introduction into cells, the psoralen was activated by exposure to long wave ultraviolet light (UVA). After time for replication and mutagenesis, progeny plasmids were recovered and the frequency of plasmids with mutations in the supF gene determined. Site-specific mutagenesis by psoralen cross-links was dependent on precise placement of the psoralen by the triple helix-forming oligonucleotide at the time of UVA treatment. The results indicated that both pyrimidine and purine motif triplexes were much less stable on replicated DNA than on DNA in vitro or in total transfected DNA. Incubation of cells with amidoanthraquinone-based triplex stabilizing compounds enhanced the stability of the pyrimidine triplex. JF - The Journal of biological chemistry AU - Lin, F L AU - Majumdar, A AU - Klotz, L C AU - Reszka, A P AU - Neidle, S AU - Seidman, M M AD - Laboratory of Molecular Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 39117 EP - 39124 VL - 275 IS - 50 SN - 0021-9258, 0021-9258 KW - Anthraquinones KW - 0 KW - Ligands KW - supF tRNA KW - triplex DNA KW - DNA KW - 9007-49-2 KW - RNA, Transfer KW - 9014-25-9 KW - Ficusin KW - KTZ7ZCN2EX KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - COS Cells KW - Anthraquinones -- chemistry KW - Ficusin -- metabolism KW - Mutagenesis, Site-Directed KW - Base Sequence KW - RNA, Transfer -- genetics KW - Transfection KW - Genetic Vectors KW - Molecular Sequence Data KW - Genes, Suppressor KW - Time Factors KW - Plasmids -- metabolism KW - DNA -- chemistry KW - Nucleic Acid Conformation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72459285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Stability+of+DNA+triplexes+on+shuttle+vector+plasmids+in+the+replication+pool+in+mammalian+cells.&rft.au=Lin%2C+F+L%3BMajumdar%2C+A%3BKlotz%2C+L+C%3BReszka%2C+A+P%3BNeidle%2C+S%3BSeidman%2C+M+M&rft.aulast=Lin&rft.aufirst=F&rft.date=2000-12-15&rft.volume=275&rft.issue=50&rft.spage=39117&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroprotective signaling and the aging brain: take away my food and let me run AN - 18138111; 4806535 AB - It is remarkable that neurons are able to survive and function for a century or more in many persons that age successfully. A better understanding of the molecular signaling mechanisms that permit such cell survival and synaptic plasticity may therefore lead to the development of new preventative and therapeutic strategies for age-related neurodegenerative disorders. We all know that overeating and lack of exercise are risk factors for many different age-related diseases including cardiovascular disease, diabetes and cancers. Our recent studies have shown that dietary restriction (reduced calorie intake) can increase the resistance of neurons in the brain to dysfunction and death in experimental models of Alzheimer's disease, Parkinson's disease, Huntington's disease and stroke. The mechanism underlying the beneficial effects of dietary restriction involves stimulation of the expression of 'stress proteins' and neurotrophic factors. The neurotrophic factors induced by dietary restriction may protect neurons by inducing the production of proteins that suppress oxyradical production, stabilize cellular calcium homeostasis and inhibit apoptotic biochemical cascades. Interestingly, dietary restriction also increases numbers of newly-generated neural cells in the adult brain suggesting that this dietary manipulation can increase the brain's capacity for plasticity and self-repair. Work in other laboratories suggests that physical and intellectual activity can similarly increase neurotrophic factor production and neurogenesis. Collectively, the available data suggest the that dietary restriction, and physical and mental activity, may reduce both the incidence and severity of neurodegenerative disorders in humans. A better understanding of the cellular and molecular mechanisms underlying these effects of diet and behavior on the brain is also leading to novel therapeutic agents that mimick the beneficial effects of dietary restriction and exercise. JF - Brain Research AU - Mattson, M P AD - Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, 21224-6825 Baltimore, MD USA Y1 - 2000/12/15/ PY - 2000 DA - 2000 Dec 15 SP - 47 EP - 53 PB - Elsevier VL - 886 IS - 1-2 SN - 0006-8993, 0006-8993 KW - man KW - CSA Neurosciences Abstracts; Physical Education Index KW - Exercise physiology KW - Age KW - Dietary restrictions KW - Physical activity KW - Aging KW - Gerontology KW - Brain KW - Stress KW - Nutrition KW - Neurodegenerative diseases KW - Nervous system KW - Reviews KW - Proteins KW - Diseases KW - Diet KW - N3 11055:Primates KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18138111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+Research&rft.atitle=Neuroprotective+signaling+and+the+aging+brain%3A+take+away+my+food+and+let+me+run&rft.au=Mattson%2C+M+P&rft.aulast=Mattson&rft.aufirst=M&rft.date=2000-12-15&rft.volume=886&rft.issue=1-2&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Brain+Research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Nervous system; Brain; Gerontology; Age; Diet; Nutrition; Diseases; Exercise physiology; Aging; Neurodegenerative diseases; Dietary restrictions; Stress; Proteins; Physical activity; Reviews ER - TY - JOUR T1 - Generation of Gene-Modified T Cells Reactive against the Angiogenic Kinase Insert Domain-Containing Receptor (KDR) Found on Tumor Vasculature AN - 17758736; 4821591 AB - The destruction of newly forming tumor vasculature is a promising approach to inhibit tumor growth. The goal of the present study was to investigate whether human lymphocytes gene modified to express a chimeric receptor specific for the angiogenic endothelial cell receptor, KDR, could react against KDR super(+) cells. Gene-modified lymphocytes specifically lysed KDR super(+) cells and secreted cytokines in response to KDR super(+) target cells including human umbilical vein endothelial cells (HUVECs). Anti-KDR lymphocytes induced HUVECs to secrete the chemokine interleukin 8 and upregulate the adhesion molecules VCAM and E-selectin, which may be important in the recruitment of further immune effector cells to tumor. These KDR-specific lymphocytes may be useful in the adoptive immunotherapy of a broad range of cancers by inducing immune-mediated destruction of tumor neovasculature. JF - Human Gene Therapy AU - Kershaw, M H AU - Westwood, JA AU - Zhu, Zhenping AU - Witte, L AU - Libutti, S K AU - Hwu, P AD - Surgery Branch, NCI, NIH Building 10, Room 2B42 9000 Rockville Pike Bethesda, MD 20892, USA, Patrick_Hwu@nih.gov Y1 - 2000/12/10/ PY - 2000 DA - 2000 Dec 10 SP - 2445 EP - 2452 VL - 11 IS - 18 SN - 1043-0342, 1043-0342 KW - man KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Microvasculature KW - Gene therapy KW - Tumors KW - Endothelium KW - Adoptive immunotherapy KW - Lymphocytes T KW - Protein kinase KW - F 06818:Cancer immunotherapy KW - F 06756:Function KW - W 30965:Miscellaneous, Reviews KW - W3 33180:Gene based (protocols, clinical trials, and animal models) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17758736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Generation+of+Gene-Modified+T+Cells+Reactive+against+the+Angiogenic+Kinase+Insert+Domain-Containing+Receptor+%28KDR%29+Found+on+Tumor+Vasculature&rft.au=Kershaw%2C+M+H%3BWestwood%2C+JA%3BZhu%2C+Zhenping%3BWitte%2C+L%3BLibutti%2C+S+K%3BHwu%2C+P&rft.aulast=Kershaw&rft.aufirst=M&rft.date=2000-12-10&rft.volume=11&rft.issue=18&rft.spage=2445&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lymphocytes T; Tumors; Microvasculature; Protein kinase; Adoptive immunotherapy; Endothelium; Gene therapy ER - TY - JOUR T1 - Preincubation with Endothelial Cell Monolayers Increases Gene Transfer Efficiency into Human Bone Marrow CD34 super(+)CD38 super(-) Progenitor Cells AN - 17755527; 4821596 AB - Retroviral gene transfer studies targeting bone marrow CD34 super(+)CD38 super(-) stem cells have been disappointing because of the rarity of these cells, their G sub(0) cell cycle status, and their low or absent expression of surface retroviral receptors. In this study, we examined whether preincubation of bone marrow CD34 super(+)CD38 super(-) stem cells with a hematopoietically supportive porcine microvascular endothelial cell line (PMVECs) could impact the cell cycle status and expression of retroviral receptors in pluripotent CD34 super(+)CD38 super(-) cells and the efficiency of gene transfer into these primitive target cells. PMVEC coculture supplemented with GM-CSF + IL-3 + IL-6 + SCF + Flt-3 ligand induced >93% of the CD34 super(+)CD38 super(-) population to enter the G sub(1) or G sub(2)/S/M phase while increasing this population from 1.4% on day 0 to 6.5% of the total population by day 5. Liquid cultures supplemented with the identical cytokines induced 73% of the CD34 super(+)CD38 super(-) population into cell cycle but did not maintain cells with the CD34 super(+)CD38 super(-) phenotype over time. We found no significant increase in the levels of AmphoR or GaLVR mRNA in PMVEC-expanded CD34 super(+)CD38 super(-) cells after coculture. Despite this, the efficiency of gene transfer using either amphotropic vector (PA317) or GaLV vector (PG13) was significantly greater in PMVEC-expanded CD34 super(+)CD38 super(-) cells (11.4 plus or minus 5.6 and 10.9 plus or minus 5.2%, respectively) than in either steady state bone marrow CD34 super(+)CD38 super(-) cells (0.6 plus or minus 1.7 and 0.2 plus or minus 0.6%, respectively; p < 0.01 and p < 0.01) or liquid culture-expanded CD34 super(+)CD38 super(-) cells (1.4 plus or minus 3.5 and 0.0%, respectively; p < 0.01 and p < 0.01). Since PMVEC coculture induces a high level of cell cycling in human bone marrow CD34 super(+)CD38 super(-) cells and expands hematopoietic cells capable of in vivo repopulation, this system offers potential advantages for application in clinical gene therapy protocols. JF - Human Gene Therapy AU - Chute, J P AU - Saini, A AU - Wells, M AU - Clark, W AU - Wu, A AU - St Louis, D AU - Blair, P AU - Harlan, D AU - Kaushal, S AD - Stem Cell Biology Laboratory, NIDDK-Navy Transplantation and Autoimmunity Branch, Building 46, Room 2417A, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA Y1 - 2000/12/10/ PY - 2000 DA - 2000 Dec 10 SP - 2515 EP - 2528 VL - 11 IS - 18 SN - 1043-0342, 1043-0342 KW - endothelial cells KW - man KW - CD34 antigen KW - CD38 antigen KW - Flt-3 ligand KW - Flt3L protein KW - stem cell factor KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Interleukin 6 KW - Gene therapy KW - Interleukin 3 KW - Cell cycle KW - Bone marrow KW - Granulocyte-macrophage colony-stimulating factor KW - Retrovirus KW - Gene transfer KW - Hemopoiesis KW - G 07443:Gene therapy KW - W 30965:Miscellaneous, Reviews KW - W3 33180:Gene based (protocols, clinical trials, and animal models) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17755527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Preincubation+with+Endothelial+Cell+Monolayers+Increases+Gene+Transfer+Efficiency+into+Human+Bone+Marrow+CD34+super%28%2B%29CD38+super%28-%29+Progenitor+Cells&rft.au=Chute%2C+J+P%3BSaini%2C+A%3BWells%2C+M%3BClark%2C+W%3BWu%2C+A%3BSt+Louis%2C+D%3BBlair%2C+P%3BHarlan%2C+D%3BKaushal%2C+S&rft.aulast=Chute&rft.aufirst=J&rft.date=2000-12-10&rft.volume=11&rft.issue=18&rft.spage=2515&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Gene transfer; Granulocyte-macrophage colony-stimulating factor; Gene therapy; Bone marrow; Retrovirus; Cell cycle; Interleukin 3; Interleukin 6; Hemopoiesis ER - TY - JOUR T1 - Ubiquitination of HIV-1 and MuLV Gag. AN - 72471461; 11112487 AB - Our previous biochemical studies of HIV-1 and MuLV virions isolated and identified mature Gag products, HIV-1 p6(Gag) and MuLV p12(Gag), that were conjugated to a single ubiquitin. To study the importance of the monoubiquitination of Gag, a series of lysine to arginine mutants were constructed that eliminated ubiquitination at one or both of the lysines in HIV-1(NL4-3) p6(Gag) and both lysines in Moloney MuLV p12(Gag). HPLC and immunoblot analysis of the HIV-1 mutants demonstrated that either of the lysines in p6(Gag), K27 or K33, could be monoubiquitinated. However, infectivity assays showed that monoubiquitination of HIV-1 p6(Gag) or MuLV p12(Gag) is not required for viral replication in vitro. Pulse-chase radiolabeling of HIV-1-producing cells revealed that monoubiquitination of p6(Gag) does not affect the short-term release of virus from the cell, the maturation of Pr55(Gag), or the sensitivity of these processes to proteasome inhibitors. Experiments with protease-deficient HIV-1 showed that Pr55(Gag) can be monoubiquitinated, suggesting that p6(Gag) is first modified as a domain within Gag. Examination of the proteins inside an HIV-1 mutant found that free ubiquitin was incorporated into the virions in the absence of the lysines in p6(Gag), showing that the ubiquitin inside the virus is not initially brought in as a p6(Gag) conjugate. Although our results establish that monoubiquitination of p6(Gag) and p12(Gag) is not required for viral replication in vitro, this modification may be a by-product of interactions between Gag and cellular proteins during assembly and budding. Copyright 2000 Academic Press. JF - Virology AU - Ott, D E AU - Coren, L V AU - Chertova, E N AU - Gagliardi, T D AU - Schubert, U AD - AIDS Vaccine Program, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702-1201, USA. ott@avpvx1.ncifcrf.gov Y1 - 2000/12/05/ PY - 2000 DA - 2000 Dec 05 SP - 111 EP - 121 VL - 278 IS - 1 SN - 0042-6822, 0042-6822 KW - Gene Products, gag KW - 0 KW - Protein Precursors KW - Ubiquitins KW - gag Gene Products, Human Immunodeficiency Virus KW - p55 gag precursor protein, Human immunodeficiency virus 1 KW - p6 gag protein, Human immunodeficiency virus 1 KW - Arginine KW - 94ZLA3W45F KW - HIV Protease KW - EC 3.4.23.- KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Virus Replication KW - Immunoblotting KW - Animals KW - Gene Products, gag -- genetics KW - HIV Protease -- genetics KW - Protein Precursors -- metabolism KW - Humans KW - Mice KW - Amino Acid Sequence KW - Lysine -- genetics KW - Gene Products, gag -- metabolism KW - Chromatography, High Pressure Liquid KW - Mutagenesis, Site-Directed KW - Arginine -- genetics KW - HIV Protease -- deficiency KW - Molecular Sequence Data KW - Amino Acid Substitution KW - Cell Line KW - Gene Products, gag -- analysis KW - HIV-1 -- metabolism KW - Moloney murine leukemia virus -- pathogenicity KW - Ubiquitins -- metabolism KW - HIV-1 -- pathogenicity KW - HIV-1 -- enzymology KW - Ubiquitins -- analysis KW - Moloney murine leukemia virus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72471461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Ubiquitination+of+HIV-1+and+MuLV+Gag.&rft.au=Ott%2C+D+E%3BCoren%2C+L+V%3BChertova%2C+E+N%3BGagliardi%2C+T+D%3BSchubert%2C+U&rft.aulast=Ott&rft.aufirst=D&rft.date=2000-12-05&rft.volume=278&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. AN - 72467792; 11104741 AB - Serotonergic medications with various mechanisms of action are used to treat psychiatric disorders and are being investigated as treatments for drug dependence. The occurrence of fenfluramine-associated valvular heart disease (VHD) has raised concerns that other serotonergic medications might also increase the risk of developing VHD. We hypothesized that fenfluramine or its metabolite norfenfluramine and other medications known to produce VHD have preferentially high affinities for a particular serotonin receptor subtype capable of stimulating mitogenesis. Medications known or suspected to cause VHD (positive controls) and medications not associated with VHD (negative controls) were screened for activity at 11 cloned serotonin receptor subtypes by use of ligand-binding methods and functional assays. The positive control drugs were (+/-)-fenfluramine; (+)-fenfluramine; (-)-fenfluramine; its metabolites (+/-)-norfenfluramine, (+)-norfenfluramine, and (-)-norfenfluramine; ergotamine; and methysergide and its metabolite methylergonovine. The negative control drugs were phentermine, fluoxetine, its metabolite norfluoxetine, and trazodone and its active metabolite m-chlorophenylpiperazine. (+/-)-, (+)-, and (-)-Norfenfluramine, ergotamine, and methylergonovine all had preferentially high affinities for the cloned human serotonin 5-HT(2B) receptor and were partial to full agonists at the 5-HT(2B) receptor. Our data imply that activation of 5-HT(2B) receptors is necessary to produce VHD and that serotonergic medications that do not activate 5-HT(2B) receptors are unlikely to produce VHD. We suggest that all clinically available medications with serotonergic activity and their active metabolites be screened for agonist activity at 5-HT(2B) receptors and that clinicians should consider suspending their use of medications with significant activity at 5-HT(2B) receptors. JF - Circulation AU - Rothman, R B AU - Baumann, M H AU - Savage, J E AU - Rauser, L AU - McBride, A AU - Hufeisen, S J AU - Roth, B L AD - Clinical Psychopharmacology Section, Division of Intramural Research, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA. Y1 - 2000/12/05/ PY - 2000 DA - 2000 Dec 05 SP - 2836 EP - 2841 VL - 102 IS - 23 KW - Receptors, Serotonin KW - 0 KW - Serotonin Antagonists KW - Norfenfluramine KW - 1886-26-6 KW - Fenfluramine KW - 2DS058H2CF KW - Ergotamine KW - PR834Q503T KW - Methylergonovine KW - W53L6FE61V KW - Index Medicus KW - Ergotamine -- pharmacokinetics KW - Serotonin Antagonists -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Ergotamine -- pharmacology KW - Serotonin Antagonists -- pharmacokinetics KW - Methylergonovine -- pharmacokinetics KW - Serotonin Antagonists -- adverse effects KW - Methylergonovine -- pharmacology KW - Receptors, Serotonin -- drug effects KW - Fenfluramine -- adverse effects KW - Norfenfluramine -- pharmacokinetics KW - Norfenfluramine -- pharmacology KW - Heart Valve Diseases -- epidemiology KW - Fenfluramine -- pharmacokinetics KW - Norfenfluramine -- adverse effects KW - Heart Valve Diseases -- chemically induced KW - Fenfluramine -- pharmacology KW - Receptors, Serotonin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72467792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation&rft.atitle=Evidence+for+possible+involvement+of+5-HT%282B%29+receptors+in+the+cardiac+valvulopathy+associated+with+fenfluramine+and+other+serotonergic+medications.&rft.au=Rothman%2C+R+B%3BBaumann%2C+M+H%3BSavage%2C+J+E%3BRauser%2C+L%3BMcBride%2C+A%3BHufeisen%2C+S+J%3BRoth%2C+B+L&rft.aulast=Rothman&rft.aufirst=R&rft.date=2000-12-05&rft.volume=102&rft.issue=23&rft.spage=2836&rft.isbn=&rft.btitle=&rft.title=Circulation&rft.issn=1524-4539&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2000-12-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Motor Strategy in Rapid Sequential Swallowing: New Insights AN - 85531960; 200107092 AB - Examined the physiological properties & movement strategies of normal, rapid sequential swallowing during simultaneous videofluoroscopy (VFS) & submental surface electromyography (EMG) in a sample of 5 men & 5 women, ages 31-55. Subjects (Ss) performed discrete (5 & 15 cc) & sequential (150 cc in tilted & upright head postures) swallowing tasks. Analyses included VFS event timing, movement/bolus passage characteristics, EMG amplitude waveforms, & peak & offset EMG amplitudes. Results revealed that sequential swallows were significantly shorter than discrete swallows in several VFS event durations, but significantly longer in pharyngeal transit & stage transition times. The hyolaryngeal system exhibited a cyclical rise & partial fall movement pattern during sequential swallows on VFS, corresponding to a repetitive activation & partial deactivation characteristic on EMG. Greater peak EMG amplitude for sequential than discrete swallows was found in 6 of the 10 Ss. Pharyngeal bolus merging, preparatory laryngeal gestures, & penetration without aspiration were also observed in some Ss on VFS. Intersubject differences were significant in timing measures & EMG amplitude. Findings of individual variability & subject-specific strategies for task accommodation support the notion of built-in plasticity in the deglutitive motor complex. 2 Tables, 4 Figures, 28 References. Adapted from the source document JF - Journal of Speech, Language, and Hearing Research AU - Chi-Fishman, Gloria AU - Sonies, Barbara C AD - Clinical Center, National Instits Health, Bethesda, MD gcf@nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1481 EP - 1492 VL - 43 IS - 6 SN - 1092-4388, 1092-4388 KW - swallowing KW - Respiratory System (73100) KW - Pharyngeal Structures (64200) KW - Vocal Tract (94900) KW - Speech Motor Control (82600) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85531960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Motor+Strategy+in+Rapid+Sequential+Swallowing%3A+New+Insights&rft.au=Chi-Fishman%2C+Gloria%3BSonies%2C+Barbara+C&rft.aulast=Chi-Fishman&rft.aufirst=Gloria&rft.date=2000-12-01&rft.volume=43&rft.issue=6&rft.spage=1481&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2003-10-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Pharyngeal Structures (64200); Speech Motor Control (82600); Vocal Tract (94900); Respiratory System (73100) ER - TY - JOUR T1 - Pathological features of lymphoid proliferations of the salivary glands: lymphoepithelial sialadenitis versus low-grade B-cell lymphoma of the malt type. AN - 85358202; pmid-11130833 AB - Lymphoid proliferations of the salivary glands can be either reactive or neoplastic. Reactive lesions include the lymphoepithelial sialadenitis (LESA; also known as myoepithelial sialadenitis [MESA]) of Sjogren's syndrome. Lymphomas of the salivary glands are predominantly B-cell type and include extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type. The spectrum of histopathologic features of LESA/MESA includes 1) "fully benign lymphoid infiltrate," with or without an associated lymphoid follicular structure, without immunoglobulin (Ig) light chain restriction in B-cells, and without any features of aggressive behavior, and 2) "lymphoproliferative lesions," with or without areas of Ig light chain restriction in B-cells, with the usual presence of centrocyte-like cells. A more or less pronounced lymphoepithelial aggressiveness may be present without definite evidence of malignancy. B-cell clones are detected in over 50% of cases of LESA/MESA by molecular genetic methods, but this does not correlate with morphological or clinical evidence of overt lymphoma. On the other hand, "marginal zone B-cell lymphoma of the MALT type" of the salivary glands produces a dense lymphoid infiltrate diffusely involving the gland, with obliteration of acini. The centrocyte-like cells form broad "halos" around the epithelial cell nests and broad strands between lymphoepithelial lesions, often linking together several lymphoepithelial lesions. Further, lymphoma cells express monotypic surface Ig, and in the majority of the cases, the plasma cells are also monoclonal. In conclusion, the diagnosis of LESA/MESA versus marginal zone B-cell lymphoma of the MALT type still relies on the evaluation of morphological features. It seems that molecular genetic analysis has little or no practical role in the clinical diagnosis of salivary gland lymphoma in a setting of LESA/MESA and Sjögren's syndrome. JF - The Annals of otology, rhinology, and laryngology AU - Carbone, A AU - Gloghini, A AU - Ferlito, A AD - Division of Pathology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy. Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 1170 EP - 1175 VL - 109 IS - 12 Pt 1 SN - 0003-4894, 0003-4894 KW - National Library of Medicine KW - Diagnosis, Differential KW - Mikulicz' Disease -- classification KW - Lymphoma, B-Cell, Marginal Zone -- classification KW - Lymphoproliferative Disorders -- etiology KW - Humans KW - Disease Progression KW - Lymphoma, B-Cell, Marginal Zone -- pathology KW - Salivary Gland Neoplasms -- classification KW - Biopsy KW - Lymphoproliferative Disorders -- classification KW - Sialadenitis -- classification KW - Sialadenitis -- pathology KW - Neoplasm Staging -- methods KW - Mikulicz' Disease -- pathology KW - Lymphoproliferative Disorders -- pathology KW - Salivary Gland Neoplasms -- pathology KW - Mikulicz' Disease -- etiology KW - Sialadenitis -- etiology KW - Sjogren's Syndrome -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85358202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.atitle=Pathological+features+of+lymphoid+proliferations+of+the+salivary+glands%3A+lymphoepithelial+sialadenitis+versus+low-grade+B-cell+lymphoma+of+the+malt+type.&rft.au=Carbone%2C+A%3BGloghini%2C+A%3BFerlito%2C+A&rft.aulast=Carbone&rft.aufirst=A&rft.date=2000-12-01&rft.volume=109&rft.issue=12+Pt+1&rft.spage=1170&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Water permeability of cochlear outer hair cells: characterization and relationship to electromotility. AN - 85280698; pmid-11124975 AB - The distinguishing feature of the mammalian outer hair cells (OHCs) is to elongate and shorten at acoustic frequencies, when their intracellular potential is changed. This "electromotility" or "electromechanics" depends critically on positive intracellular pressure (turgor), maintained by the inflow of water through yet uncharacterized water pathways. We measured the water volume flow, J(v), across the plasma membrane of isolated guinea pig and rat OHCs after osmotic challenges and estimated the osmotic water permeability coefficient, P(f), to be approximately 10(-2) cm/sec. This value is within the range reported for osmotic flow mediated by the water channel proteins, aquaporins. J(v) was inhibited by HgCl(2), which is known to block aquaporin-mediated water transport. P(f) values that were estimated for OHCs from neonatal rats were of the order of approximately 2 x 10(-3) cm/sec, equivalent to that of membranes lacking water channel proteins. In an immunofluorescence assay we showed that an anti-peptide antibody specific for aquaporins labels the lateral plasma membrane of the OHC in the region in which electromotility is generated. Using patch-clamp recording, we found that water influx into the OHC is regulated by intracellular voltage. We also found that the most pronounced increases of the electromotility-associated charge movement and of the expression of OHC water channels occur between postnatal days 8 and 12, preceding the onset of hearing function in the rat. Our data indicate that electromotility and water transport in OHCs may influence each other structurally and functionally. JF - The Journal of Neuroscience AU - Belyantseva, I A AU - Frolenkov, G I AU - Wade, J B AU - Mammano, F AU - Kachar Bechara AD - Section on Structural Cell Biology, National Institute on Deafness and other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA.; National Institute on Deafness and Other Communication Disorders PY - 2000 SP - 8996 EP - 9003 VL - 20 IS - 24 SN - 0270-6474, 0270-6474 KW - Aquaporins KW - In Vitro KW - Cell Size KW - Guinea Pigs KW - Aging KW - Animal KW - Biological Transport KW - Water KW - Rats KW - Hypotonic Solutions KW - Cell Membrane KW - Support, Non-U.S. Gov't KW - Fluorescent Antibody Technique KW - Mercuric Chloride KW - Cochlea KW - Osmolar Concentration KW - Dose-Response Relationship, Drug KW - Electrophysiology KW - Blotting, Western KW - Antibodies KW - Patch-Clamp Techniques KW - Cells, Cultured KW - Hair Cells, Outer KW - Cell Membrane Permeability KW - Immunohistochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85280698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Water+permeability+of+cochlear+outer+hair+cells%3A+characterization+and+relationship+to+electromotility.&rft.au=Belyantseva%2C+I+A%3BFrolenkov%2C+G+I%3BWade%2C+J+B%3BMammano%2C+F%3BKachar+Bechara&rft.aulast=Belyantseva&rft.aufirst=I&rft.date=2000-12-01&rft.volume=20&rft.issue=24&rft.spage=8996&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Cytokine gene expression in different strains of mice with endotoxin-induced uveitis (EIU). AN - 72596603; 11262651 AB - The kinetics of various cytokines in the eye plays a critical role in endotoxin-induced uveitis (EIU). This study examined the cytokine kinetics and susceptibility of EIU in four mice strains. Four strains of TLR-4 or Toll-like receptor-4 (Lps, lipopolysaccharide-susceptible) gene-positive mice (C3H/HeN of H-2(k), C57/B6 of H-2(b), Balb/C of H-2(d), and 129/J of H-2(b)) were injected subcutaneously with either lipopolysaccharide (LPS) in phosphate-buffered saline (PBS) or PBS alone in two repeated experiments. Mice were sacrificed 1, 3, 6, 24 (1 d), 72 (3 d), 120 (5 d), or 168 (7 d) hours after LPS injection. Ocular histology and reverse transcriptase-polymerase chain reaction (RT-PCR) to detect ocular interleukin-1 alpha (IL-1 alpha), IL-6, tumor necrosis factor-alpha (TNF-alpha), and granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA were performed. Serum IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha levels were measured using enzyme-linked immunosorbent assay (ELISA). No ocular inflammation was present in any mice within six hours after LPS injection. Only the C3H/HeN mice developed a biphasic ocular inflammatory response (1 d and 5 d), during which all proinflammatory cytokine messages were expressed. In the other three strains with minimal (129/J and Balb/C) to mild (C57/B6) EIU that peaked at 1 d, IL-6 mRNA was barely detectable in C57/B6 and Balb/C; GM-CSF mRNA was also present in C57/B6. Serum IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha were high in all EIU mice within six hours after LPS injection. Control mice did not develop uveitis or measurable cytokine messages. In the most susceptible strain, C3H/HeN, EIU was biphasic and correlated to multiple proinflammatory cytokines released in the eye. The less susceptible mice strains exhibited a monophasic response to LPS that may result from no cytokine cascade. JF - Ocular immunology and inflammation AU - Shen, D F AU - Buggage, R R AU - Eng, H C AU - Chan, C C AD - Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 221 EP - 225 VL - 8 IS - 4 SN - 0927-3948, 0927-3948 KW - Biomarkers KW - 0 KW - Cytokines KW - Lipopolysaccharides KW - RNA, Messenger KW - Index Medicus KW - Severity of Illness Index KW - Animals KW - Mice, Inbred C57BL KW - Mice, Inbred C3H KW - Gene Expression KW - Enzyme-Linked Immunosorbent Assay KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Inbred BALB C KW - Female KW - Cytokines -- genetics KW - Uveitis -- genetics KW - Lipopolysaccharides -- toxicity KW - Uveitis -- metabolism KW - Salmonella typhimurium KW - Uveitis -- chemically induced KW - RNA, Messenger -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72596603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ocular+immunology+and+inflammation&rft.atitle=Cytokine+gene+expression+in+different+strains+of+mice+with+endotoxin-induced+uveitis+%28EIU%29.&rft.au=Shen%2C+D+F%3BBuggage%2C+R+R%3BEng%2C+H+C%3BChan%2C+C+C&rft.aulast=Shen&rft.aufirst=D&rft.date=2000-12-01&rft.volume=8&rft.issue=4&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Ocular+immunology+and+inflammation&rft.issn=09273948&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-06-07 N1 - Date created - 2001-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vasoactive intestinal peptide (VIP) exacerbates endotoxin-induced uveitis (EIU) in mice. AN - 72591854; 11262614 AB - We have previously shown that inhibition of the proinflammatory cytokine tumor necrosis factor- (TNF)-alpha exacerbates the inflammatory process of EIU. To further examine this paradoxic phenomenon, we investigated here the effect on EIU of VIP, a neuropeptide that inbibits TNF-alpha production. VIP was injected concurrently with endotoxin at doses that induce EIU or lethality in mice. Severity of EIU was measured by counting infiltrating cells in eye sections, at 1 or 5 days post endotoxin injection. Survival of mice was monitored periodically, while serum levels of TNF-alpha, interleukin-(IL)-1beta and IL-10 were determined by caputure ELISA. Treatment with VIP exacerbated EIU but provided partial protection from the lethal endotoxin effect. VIP treatment also reduced serum levels of TNF-alpha and IL-1beta, but increased levels of IL-10. This study further established the paradoxical observation that EIU is exacerbated by lowering the levels of circulating pro-inflammatory cytokines, in particular TNF-alpha. JF - Current eye research AU - Zhang, M AU - Hung, L AU - Gery, I AD - Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland, United States of America. zhangm@intra.nei.nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 913 EP - 917 VL - 21 IS - 6 SN - 0271-3683, 0271-3683 KW - Endotoxins KW - 0 KW - Interleukin-1 KW - Tumor Necrosis Factor-alpha KW - Interleukin-10 KW - 130068-27-8 KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Index Medicus KW - Animals KW - Staphylococcal Infections -- prevention & control KW - Endotoxemia -- prevention & control KW - Mice KW - Mice, Inbred BALB C KW - Anterior Eye Segment -- pathology KW - Interleukin-1 -- blood KW - Mice, Inbred C3H KW - Enzyme-Linked Immunosorbent Assay KW - Interleukin-10 -- blood KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Tumor Necrosis Factor-alpha -- metabolism KW - Interleukin-1 -- antagonists & inhibitors KW - Vasoactive Intestinal Peptide -- pharmacology KW - Uveitis, Anterior -- chemically induced KW - Uveitis, Anterior -- pathology KW - Staphylococcus KW - Uveitis, Anterior -- blood KW - Endotoxins -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72591854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+eye+research&rft.atitle=Vasoactive+intestinal+peptide+%28VIP%29+exacerbates+endotoxin-induced+uveitis+%28EIU%29+in+mice.&rft.au=Zhang%2C+M%3BHung%2C+L%3BGery%2C+I&rft.aulast=Zhang&rft.aufirst=M&rft.date=2000-12-01&rft.volume=21&rft.issue=6&rft.spage=913&rft.isbn=&rft.btitle=&rft.title=Current+eye+research&rft.issn=02713683&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Emerging trends in the treatment of rapid cycling bipolar disorder: a selected review. AN - 72570947; 11252642 AB - Recent evidence suggests that lithium therapy (even as supplemented by antidepressants and neuroleptics) is inadequate for the majority of patients with bipolar illness, and particularly those with rapid cycling. Valproate and carbamazepine have emerged as adjuncts and alternatives, but they, too, often require additional approaches with lithium, thyroid hormones, and other putative mood stabilizers, including nimodipine (and related dihydropyridine calcium channel blockers), lamotrigine, gabapentin, topiramate, and the atypical neuroleptics. Evaluating how these agents and the unimodal antidepressants are optimally applied and sequenced in the treatment of bipolar illness with its multiple subtypes, patterns and comorbidities will require much future investigation and the development of new methodological clinical trial approaches. JF - Bipolar disorders AU - Post, R M AU - Frye, M A AU - Denicoff, K D AU - Leverich, G S AU - Dunn, R T AU - Osuch, E A AU - Speer, A M AU - Obrocea, G AU - Jajodia, K AD - Biological Psychiatry Branch, National Institute of Mental Health, NIH, Bethesda, MD 20892-1272, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 305 EP - 315 VL - 2 IS - 4 SN - 1398-5647, 1398-5647 KW - Anticonvulsants KW - 0 KW - Antidepressive Agents KW - Antipsychotic Agents KW - Calcium Channel Blockers KW - Lithium Compounds KW - Index Medicus KW - Drug Therapy, Combination KW - Drug Tolerance KW - Randomized Controlled Trials as Topic KW - Substance Withdrawal Syndrome KW - Humans KW - Practice Guidelines as Topic KW - Cyclothymic Disorder -- drug therapy KW - Algorithms KW - Remission Induction KW - Antipsychotic Agents -- therapeutic use KW - Bipolar Disorder -- drug therapy KW - Lithium Compounds -- therapeutic use KW - Antidepressive Agents -- therapeutic use KW - Anticonvulsants -- therapeutic use KW - Calcium Channel Blockers -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72570947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bipolar+disorders&rft.atitle=Emerging+trends+in+the+treatment+of+rapid+cycling+bipolar+disorder%3A+a+selected+review.&rft.au=Post%2C+R+M%3BFrye%2C+M+A%3BDenicoff%2C+K+D%3BLeverich%2C+G+S%3BDunn%2C+R+T%3BOsuch%2C+E+A%3BSpeer%2C+A+M%3BObrocea%2C+G%3BJajodia%2C+K&rft.aulast=Post&rft.aufirst=R&rft.date=2000-12-01&rft.volume=2&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Bipolar+disorders&rft.issn=13985647&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-12 N1 - Date created - 2001-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bilirubin UDP-glucuronosyltransferase 1A1 gene polymorphisms: susceptibility to oxidative damage and cancer? AN - 72564835; 11170257 AB - The UDP-glucuronosyltransferase 1A1 (UGT1A1) gene product catalyzes the glucuronidation of serum bilirubin as part of normal heme catabolism. Recently, TA repeat polymorphisms containing five, six, seven, and eight TA dinucleotides in a putative TATA box in the promoter region of the UGT1A1 gene have been described. TA repeat number modulates UGT1A1 transcriptional activity and the quantity of enzyme available to conjugate serum bilirubin. Serum bilirubin is a known antioxidant, and low serum bilirubin has been associated with increased risk for coronary artery disease and inhibition of reactive oxygen species (ROS)-induced damage to erythrocytes in vitro. We hypothesize that the UGT1A1 TA repeats or other functional polymorphisms resulting in lower serum bilirubin levels may be predictive of genetic susceptibility to oxidative damage and cancer. Exposure-related or endogenous production of ROS may impact the integrity of cellular macromolecules and infrastructure, lead to DNA base changes or chromosomal aberrations, and induce toxicity or apoptosis. ROS damage to lipoproteins may be a factor in formation of atherogenic plaques in coronary heart disease. Thus, cellular oxidative stress could contribute to tumorigenesis through mutagenic or epigenetic pathways, and higher serum bilirubin levels should inhibit this process. No definitive studies have been performed, but in a small prospective study of colon cancer, serum bilirubin levels were observed to be lower in these cases. Another study has suggested a link between UGT1A1 alleles, estrogen metabolism, and risk in breast cancer. Epidemiologic studies examining variation in ROS metabolism, ROS damage, bilirubin, and cancer risk will demonstrate the value of this hypothesis. JF - Molecular carcinogenesis AU - Grant, D J AU - Bell, D A AD - Laboratory of Computational Biology and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 198 EP - 204 VL - 29 IS - 4 SN - 0899-1987, 0899-1987 KW - Antioxidants KW - 0 KW - Reactive Oxygen Species KW - UGT1A1 enzyme KW - EC 2.4.1.- KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Genetic Variation KW - DNA Damage KW - Polymorphism, Genetic KW - Humans KW - Neoplasms -- genetics KW - Antioxidants -- metabolism KW - Neoplasms -- pathology KW - Oxidative Stress KW - Promoter Regions, Genetic -- genetics KW - Genetic Predisposition to Disease KW - Neoplasms -- metabolism KW - Glucuronosyltransferase -- genetics KW - Bilirubin -- metabolism KW - Glucuronosyltransferase -- metabolism KW - Bilirubin -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72564835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Bilirubin+UDP-glucuronosyltransferase+1A1+gene+polymorphisms%3A+susceptibility+to+oxidative+damage+and+cancer%3F&rft.au=Grant%2C+D+J%3BBell%2C+D+A&rft.aulast=Grant&rft.aufirst=D&rft.date=2000-12-01&rft.volume=29&rft.issue=4&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - JC virus as a marker of human migration to the Americas. AN - 72560410; 11165934 AB - JC virus is a ubiquitous human polyomavirus present in populations worldwide. Seven genotypes differing in DNA sequence by approximately 1-3% characterize three Old World population groups (African, European and Asian) as well as Oceania. It is possible to follow Old World populations into the New World by the JC virus genotypes they carried. The first population to settle in the Americas, the Native Americans, brought with them type 2A from northeast Asia. European settlers arriving after Columbus carried primarily type 1 and type 4. Africans brought by the slave trade carried type 3 and type 6. JF - Microbes and infection AU - Stoner, G L AU - Jobes, D V AU - Fernandez Cobo, M AU - Agostini, H T AU - Chima, S C AU - Ryschkewitsch, C F AD - Neurotoxicology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. stonerg@ninds.nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1905 EP - 1911 VL - 2 IS - 15 SN - 1286-4579, 1286-4579 KW - Biomarkers KW - 0 KW - Index Medicus KW - Phylogeny KW - Humans KW - Americas -- epidemiology KW - JC Virus -- genetics KW - JC Virus -- classification KW - Genetics, Population KW - Polyomavirus Infections -- virology KW - Polyomavirus Infections -- epidemiology KW - Emigration and Immigration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72560410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+infection&rft.atitle=JC+virus+as+a+marker+of+human+migration+to+the+Americas.&rft.au=Stoner%2C+G+L%3BJobes%2C+D+V%3BFernandez+Cobo%2C+M%3BAgostini%2C+H+T%3BChima%2C+S+C%3BRyschkewitsch%2C+C+F&rft.aulast=Stoner&rft.aufirst=G&rft.date=2000-12-01&rft.volume=2&rft.issue=15&rft.spage=1905&rft.isbn=&rft.btitle=&rft.title=Microbes+and+infection&rft.issn=12864579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-07-26 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurochemical neutralization of amphetamine-type stimulants in rat brain by the indatraline analog (-)-HY038. AN - 72557957; 11179849 AB - Amphetamine-type stimulants are substrates for the proteins that serve as transporters for the biogenic amines dopamine (DA), serotonin (5HT), and norepinephrine (NE) and release these neurotransmitters from neurons located in the peripheral and central nervous system. Using indatraline as a lead compound, we sought to develop a long-acting depot medication that would neutralize the deleterious effects of amphetamine-type stimulants. Our first efforts produced (+/-)-HY038, and its two stereoisomers, which are hydroxy-substituted analog of indatraline. The K(i) values for [(3)H]DA reuptake inhibition by (-)-HY038 and (+)-HY038 were 3.2 +/- 0.1 and 32 +/- 1 nM. Similar results were obtained for [(3)H]5HT reuptake inhibition. (-)-HY038 and (+)-HY038 were slightly less potent at inhibiting [(3)H]NE reuptake (K(i) values of 20 +/- 2 and 159 +/- 12 nM). Low doses of (-)-HY038 blunted the ability of AMPH to release [(3)H]DA by shifting the AMPH dose-response curve to the right in a dose-dependent manner. (-)-HY038 also inhibited the ability of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine ((+/-)-MDMA) to release [(3)H]DA. Low doses of (-)-HY038 blunted the ability of these stimulants to release [(3)H]NE and [(3)H]5HT by shifting their dose-response curves to the right in a manner similar to that seen for inhibition of [(3)H]DA release. These data indicate that (-)-HY038 inhibits the ability of AMPH, (+)-methamphetamine and (+/-)-MDMA to release DA, NE, and 5HT and therefore might have the potential to neutralize the neurotoxic and cardiovascular side-effects of substrate-type stimulants. JF - Brain research bulletin AU - Partilla, J S AU - Dersch, C M AU - Yu, H AU - Rice, K C AU - Rothman, R B AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 821 EP - 826 VL - 53 IS - 6 SN - 0361-9230, 0361-9230 KW - Amphetamines KW - 0 KW - Biogenic Monoamines KW - Carrier Proteins KW - Central Nervous System Stimulants KW - HY 038 KW - Indans KW - Methylamines KW - Neurotransmitter Uptake Inhibitors KW - Tritium KW - 10028-17-8 KW - indatraline KW - 4U40Y96J1Z KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Synaptosomes -- drug effects KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- drug effects KW - Dopamine -- pharmacokinetics KW - Radioligand Assay KW - Biogenic Monoamines -- metabolism KW - Synaptosomes -- metabolism KW - Male KW - Amphetamine-Related Disorders -- metabolism KW - Central Nervous System Stimulants -- pharmacology KW - Brain -- drug effects KW - Amphetamines -- agonists KW - Brain -- metabolism KW - Neurotransmitter Uptake Inhibitors -- metabolism KW - Indans -- metabolism KW - Amphetamine-Related Disorders -- physiopathology KW - Brain -- physiopathology KW - Methylamines -- agonists KW - Indans -- pharmacology KW - Indans -- agonists KW - Methylamines -- metabolism KW - Neurotransmitter Uptake Inhibitors -- agonists KW - Amphetamine-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72557957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research+bulletin&rft.atitle=Neurochemical+neutralization+of+amphetamine-type+stimulants+in+rat+brain+by+the+indatraline+analog+%28-%29-HY038.&rft.au=Partilla%2C+J+S%3BDersch%2C+C+M%3BYu%2C+H%3BRice%2C+K+C%3BRothman%2C+R+B&rft.aulast=Partilla&rft.aufirst=J&rft.date=2000-12-01&rft.volume=53&rft.issue=6&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Brain+research+bulletin&rft.issn=03619230&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-10 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Laser capture microdissection: beyond functional genomics to proteomics. AN - 72553209; 11172494 AB - Proteomics will drive biology and medicine beyond genomics, and can have a profound impact on molecular diagnostics. The posttranslational modifications of cellular proteins that govern physiology and become deranged in disease cannot be accurately portrayed by gene expression alone. Consequently, new technology is being developed to discover, and quantitatively monitor, proteomic changes that are associated with disease etiology and progression. In the past, proteomic technologies were restricted to tumor cell lines or homogenized bulk tissue specimens. This source material may not accurately reflect molecular events taking place in the specific cells of the tissue itself. This article describes a completely new class of proteomic-based approaches aimed at the identification and investigation of protein markers in the actual histologically defined cell populations that are immersed in heterogeneous diseased tissue. It is envisioned that these investigations will eventually lead to novel diagnostic, prognostic, or therapeutic markers that can be applied to monitor therapeutic toxicity or efficacy. JF - Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology AU - Simone, N L AU - Paweletz, C P AU - Charboneau, L AU - Petricoin, E F AU - Liotta, L A AD - Laboratory of Pathology, National Cancer Institute/NIH, Building 10, 10 Center Drive, Bethesda, MD 20892-1500, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 301 EP - 307 VL - 5 IS - 4 SN - 1084-8592, 1084-8592 KW - DNA, Complementary KW - 0 KW - Proteins KW - Proteome KW - Index Medicus KW - Microscopy -- trends KW - Microscopy -- methods KW - Humans KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - DNA, Complementary -- isolation & purification KW - Proteins -- genetics KW - Microscopy -- instrumentation KW - Dissection -- trends KW - Dissection -- instrumentation KW - Lasers KW - Dissection -- methods KW - Genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72553209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+diagnosis+%3A+a+journal+devoted+to+the+understanding+of+human+disease+through+the+clinical+application+of+molecular+biology&rft.atitle=Laser+capture+microdissection%3A+beyond+functional+genomics+to+proteomics.&rft.au=Simone%2C+N+L%3BPaweletz%2C+C+P%3BCharboneau%2C+L%3BPetricoin%2C+E+F%3BLiotta%2C+L+A&rft.aulast=Simone&rft.aufirst=N&rft.date=2000-12-01&rft.volume=5&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Molecular+diagnosis+%3A+a+journal+devoted+to+the+understanding+of+human+disease+through+the+clinical+application+of+molecular+biology&rft.issn=10848592&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Japanese version of Substance Abuse Subtle Screening Inventory and its psychometric assessment. AN - 72542245; 11197873 AB - The purpose of our study was the development of the Japanese version of the Substance Abuse Subtle Screening Inventory (SASSI) and its psychometric assessment. We translated SASSI-3 into Japanese and refined it through a back-translation technique and focus group approach. Study 1 was a preliminary study to examine the internal consistency and discriminant function of subscales, sensitivity and specificity of the Japanese version SASSI-3 (SASSI-3J). The participants were 20 drug-dependent individuals and 23 non-dependent comparison individuals. Study 2 comprised three parts. The participants were university students recruited from three classes. The first part examined the internal consistency of subscales and the relationship between the subscale Face Valid Alcohol (FVA) and the Kurihama Alcoholism Screening Test (KAST) with 269 students. The second part examined the 2-week test-retest reliability with 51 students. The third part examined the robustness of SASSI-3J against response distortion with 65 students: participants completed the SASSI-3J under standard instructions, under instructions to minimize any alcohol problems they might have (fake good), and under instructions to exaggerate any alcohol problems they might have (fake bad). They also completed the Social Desirability Scale. 1) SASSI-3J showed relatively high sensitivity and specificity when only the Risk Prediction Scales were used or when Rule 9 was excluded from the decision tree; 2) The Risk Prediction Scales of SASSI-3J had high internal consistency, and among them, Face Valid Alcohol (FVA) showed moderately high concurrent validity with the KAST; 3) In both Study 1 and Study 2, the internal consistencies of OAT, SAT, DEF and SAM were moderate to low (0.05 to 0.57). This may not interfere with the subscales' discriminant power but does deny sufficient uni-dimensionality of these scales; 4) SASSI-3J clinical scale scores were shown to be robust against faking good/social desirability bias. JF - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence AU - Kikuchi, A AU - Wada, K AD - Division of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 1-7-3 Kohnodai, Ichikawa City, Chiba 272-0827, Japan. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 388 EP - 401 VL - 35 IS - 6 SN - 1341-8963, 1341-8963 KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Adult KW - Male KW - Japan KW - Female KW - Substance-Related Disorders -- diagnosis KW - Mass Screening KW - Personality Inventory -- standards KW - Psychometrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72542245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.atitle=The+Japanese+version+of+Substance+Abuse+Subtle+Screening+Inventory+and+its+psychometric+assessment.&rft.au=Kikuchi%2C+A%3BWada%2C+K&rft.aulast=Kikuchi&rft.aufirst=A&rft.date=2000-12-01&rft.volume=35&rft.issue=6&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.issn=13418963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-29 N1 - Date created - 2001-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Minimization and management of wastes from biomedical research. AN - 72536759; 11121362 AB - Several committees were established by the National Association of Physicians for the Environment to investigate and report on various topics at the National Leadership Conference on Biomedical Research and the Environment held at the 1--2 November 1999 at the National Institutes of Health in Bethesda, Maryland. This is the report of the Committee on Minimization and Management of Wastes from Biomedical Research. Biomedical research facilities contribute a small fraction of the total amount of wastes generated in the United States, and the rate of generation appears to be decreasing. Significant reductions in generation of hazardous, radioactive, and mixed wastes have recently been reported, even at facilities with rapidly expanding research programs. Changes in the focus of research, improvements in laboratory techniques, and greater emphasis on waste minimization (volume and toxicity reduction) explain the declining trend in generation. The potential for uncontrolled releases of wastes from biomedical research facilities and adverse impacts on the general environment from these wastes appears to be low. Wastes are subject to numerous regulatory requirements and are contained and managed in a manner protective of the environment. Most biohazardous agents, chemicals, and radionuclides that find significant use in research are not likely to be persistent, bioaccumulative, or toxic if they are released. Today, the primary motivations for the ongoing efforts by facilities to improve minimization and management of wastes are regulatory compliance and avoidance of the high disposal costs and liabilities associated with generation of regulated wastes. The committee concluded that there was no evidence suggesting that the anticipated increases in biomedical research will significantly increase generation of hazardous wastes or have adverse impacts on the general environment. This conclusion assumes the positive, countervailing trends of enhanced pollution prevention efforts by facilities and reductions in waste generation resulting from improvements in research methods will continue. JF - Environmental health perspectives AU - Rau, E H AU - Alaimo, R J AU - Ashbrook, P C AU - Austin, S M AU - Borenstein, N AU - Evans, M R AU - French, H M AU - Gilpin, R W AU - Hughes, J AU - Hummel, S J AU - Jacobsohn, A P AU - Lee, C Y AU - Merkle, S AU - Radzinski, T AU - Sloane, R AU - Wagner, K D AU - Weaner, L E AD - Environmental Protection Branch, Division of Safety, Office of Research Services, National Institutes of Health, Bethesda, Maryland 20892-5746, USA. edrau@helix.nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 953 EP - 977 VL - 108 Suppl 6 SN - 0091-6765, 0091-6765 KW - Hazardous Waste KW - 0 KW - Medical Waste Disposal KW - Index Medicus KW - Policy Making KW - Drug Industry KW - Humans KW - Facility Design and Construction KW - Public Policy KW - Leadership KW - Biomedical Technology KW - Conservation of Natural Resources KW - Environmental Pollution -- prevention & control KW - Medical Waste Disposal -- methods KW - Medical Waste Disposal -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72536759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Minimization+and+management+of+wastes+from+biomedical+research.&rft.au=Rau%2C+E+H%3BAlaimo%2C+R+J%3BAshbrook%2C+P+C%3BAustin%2C+S+M%3BBorenstein%2C+N%3BEvans%2C+M+R%3BFrench%2C+H+M%3BGilpin%2C+R+W%3BHughes%2C+J%3BHummel%2C+S+J%3BJacobsohn%2C+A+P%3BLee%2C+C+Y%3BMerkle%2C+S%3BRadzinski%2C+T%3BSloane%2C+R%3BWagner%2C+K+D%3BWeaner%2C+L+E&rft.aulast=Rau&rft.aufirst=E&rft.date=2000-12-01&rft.volume=108+Suppl+6&rft.issue=&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-20 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharm Pharmacol. 1990 Oct;42(10):741-2 [1707456] J Clin Eng. 1991 Mar-Apr;16(2):137-44 [10110257] J Appl Bacteriol. 1992 Jul;73(1):1-6 [1512173] J R Soc Med. 1992 Sep;85(9):553-5 [1433125] Health Phys. 1993 Jan;64(1):86-90 [8416222] Health Phys. 1993 Aug;65(2):193-9 [8330967] Health Phys. 1993 Nov;65(5):556-9 [8225997] Am J Crit Care. 1994 Jan;3(1):40-54 [8118492] Pediatr Nurs. 1994 Jan-Feb;20(1):58-63 [8159486] Health Phys. 1995 Jul;69(1):1-5 [7790201] Health Phys. 1995 Jul;69(1):115-6 [7790204] Health Phys. 1995 Jul;69(1):117-20 [7790205] J Hum Hypertens. 1995 Dec;9(12):933-4 [8746636] Vet Hum Toxicol. 1996 Feb;38(1):48-9 [8825752] Environ Health Perspect. 1996 Jul;104(7):708-10 [8841755] J Appl Bacteriol. 1996 Nov;81(5):538-44 [8939032] Todays Surg Nurse. 1996 Jul-Aug;18(4):23-6 [8991726] Appl Microbiol Biotechnol. 1996 Dec;46(5-6):587-92 [9008891] Ecotoxicol Environ Saf. 1997 Mar;36(2):174-9 [9126435] AORN J. 1996 Jan;63(1):236-8 [9131112] Appl Environ Microbiol. 1997 Jul;63(7):2607-12 [9212410] Am Ind Hyg Assoc J. 1997 Nov;58(11):800-8 [9373926] Cancer J Sci Am. 1998 Jan-Feb;4(1):2-11 [9467038] J Clin Oncol. 1998 Apr;16(4):1479-89 [9552055] Chemosphere. 1998 Jan;36(2):357-93 [9569937] Public Health Rep. 1998 May-Jun;113(3):268-72 [9633875] JAMA. 1998 Aug 12;280(6):501-2 [9707129] Appl Environ Microbiol. 1998 Sep;64(9):3499-502 [9726904] Clin Cancer Res. 1998 Oct;4(10):2357-62 [9796965] CMAJ. 1998 Nov 3;159(9):1129-36 [9835883] Am J Infect Control. 1999 Apr;27(2):165-75 [10196493] Environ Health Perspect. 1999 Dec;107 Suppl 6:907-38 [10592150] Vet J. 2000 Jan;159(1):10-7 [10640408] J Hosp Infect. 1999 Dec;43 Suppl:S69-76 [10658760] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3418-21 [10716712] Environ Health Perspect. 2000 Dec;108 Suppl 6:949-51 [11121361] Am J Public Health. 2001 Mar;91(3):513-4 [11236453] Health Lab Sci. 1976 Oct;13(4):238-45 [789292] Life Sci. 1977 Jan 15;20(2):337-41 [839964] Can J Microbiol. 1978 Jul;24(7):886-8 [354758] Appl Environ Microbiol. 1983 Jul;46(1):227-32 [6614905] Am J Hosp Pharm. 1984 Jan;41(1):87-93 [6695939] J Pharm Pharmacol. 1985 Jan;37(1):1-12 [2858520] Appl Environ Microbiol. 1985 Oct;50(4):930-3 [4083887] MMWR Morb Mortal Wkly Rep. 1988 Jun 24;37(24):377-82, 387-8 [2836717] Health Phys. 1989 Apr;56(4):571-2 [2925402] J R Soc Health. 1989 Jun;109(3):110-1 [2501484] JAMA. 1989 Sep 22-29;262(12):1635-40 [2549278] Health Phys. 1990 Oct;59(4):461-70 [2398014] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activities of the National Institutes of Health relating to energy efficiency and pollution prevention. AN - 72532787; 11121359 AB - The National Institutes of Health (NIH) is one of the world's premier biomedical research centers. Although NIH owns and operates more than 1,300 acres and 197 buildings across the country, the main campus is in Bethesda, Maryland. This campus consists of over 312 acres and 75 laboratories and other buildings, which consume vast amounts of energy. Aware of the NIH role in setting biomedical research agendas and priorities, its administrators strive to set good examples in energy efficiency and pollution prevention. Three current projects are presented as "best practices" examples of meeting the stated commitment of NIH to leadership in environmental stewardship: a) design and current construction of a 250-bed clinical research hospital designed to allow conversion of patient care units to research laboratories and vice-versa; b) design and construction of a six-story research laboratory that combines energy-saving innovations with breakthroughs in research technologies; and c) a massive, $200-million modernization of the campus utility infrastructure that involves generation systems for steam and chilled water and distribution systems for chilled water, steam, potable water, electricity, communications and computer networking, compressed air, and natural gas. Based on introduction of energy-efficiency measures, millions of dollars in savings for energy needs are projected; already the local electric utility has granted several million dollars in rebates. The guiding principles of NIH environmental stewardship help to ensure that energy conservation measures maximize benefits versus cost and also balance expediency with efficiency within available funding resources. This is a committee report for the Leadership Conference: Biomedical Research and the Environment held 1--2 November 1999 at the National Institutes of Health, Bethesda, Maryland. JF - Environmental health perspectives AU - Ficca, S A AU - Chyun, Y D AU - Ebrahimi, M AU - Kutlak, F AU - Memarzadeh, F AD - Office of Research Services, National Institutes of Health, Bethesda, Maryland 20892, USA. ficcas@ors.od.nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 939 EP - 944 VL - 108 Suppl 6 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - United States KW - Humans KW - Facility Design and Construction KW - Public Policy KW - Environmental Pollution -- prevention & control KW - National Institutes of Health (U.S.) KW - Conservation of Natural Resources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72532787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Activities+of+the+National+Institutes+of+Health+relating+to+energy+efficiency+and+pollution+prevention.&rft.au=Ficca%2C+S+A%3BChyun%2C+Y+D%3BEbrahimi%2C+M%3BKutlak%2C+F%3BMemarzadeh%2C+F&rft.aulast=Ficca&rft.aufirst=S&rft.date=2000-12-01&rft.volume=108+Suppl+6&rft.issue=&rft.spage=939&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-20 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transforming growth factor-beta 1 and its receptors in human lung cancer and mouse lung carcinogenesis. AN - 72532121; 11195465 AB - The transforming growth factor-betas (TGF-beta s) are multifunctional proteins that inhibit the proliferation of many epithelial cells through a set of cell protein receptors that includes the TGF-beta type I (RI) and type II (RII) receptors. Loss of growth inhibition by TGF-beta is thought to contribute to the development of many types of tumors. In the present study, we have examined expression of the proteins and mRNAs for TGF-beta 1, TGF-beta RI, and TGF-beta RII in normal human lung, well-characterized non-small cell lung cancer (NSCLC) cell lines, and primary NSCLC specimens. Immunohistochemical staining for TGF-beta 1, TGF-beta RI, and TGF-beta RII using specific antibodies in normal human lung showed expression of the 3 proteins in the epithelium of bronchi and bronchioles as well as in alveoli. Differential expression of TGF-beta RI and TGF-beta RII proteins was detected in 5 NSCLC cell lines using Western blot analysis, with reduced levels in 3 cell lines. A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas. In situ hybridization studies conducted with specific riboprobes for TGF-beta 1, TGF-beta RI, and TGF-beta RII showed corresponding localization of expression of the mRNAs in the specimens that showed positive immunostaining for the proteins. To investigate the roles of TGF-beta 1, TGF-beta RI, and TGF-beta RII in chemically induced mouse lung tumorigenesis, we examined the expression of their proteins and mRNAs in 2 mouse model systems. Whereas expression of the proteins and mRNAs for TGF-beta 1 and TGF-beta RI was comparable in lung adenomas and bronchioles of A/J mice treated with benzo(alpha)pyrene, decreased immunostaining and hybridization for TGF-beta RII protein and mRNA was detected in 50% of lung adenomas in these mice. Interestingly, expression of TGF-beta 1 and the TGF-beta receptor proteins was similar to that of bronchioles in C57B1/6 mice and their littermates heterozygous for deletion of the TGF-beta 1 gene treated with diethylnitrosamine. These data show that reduced levels of expression of TGF-beta RII occur in some, but not all, human and mouse lung tumors. This suggests that different mechanisms of action, some of which may involve the TGF-beta signaling pathway, may contribute to the progression of lung tumorigenesis. JF - Experimental lung research AU - Kang, Y AU - Prentice, M A AU - Mariano, J M AU - Davarya, S AU - Linnoila, R I AU - Moody, T W AU - Wakefield, L M AU - Jakowlew, S B AD - Medicine Branch, National Cancer Institute, 9610 Medical Center Drive, Suite 300, Rockville, MD 20850, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 685 EP - 707 VL - 26 IS - 8 SN - 0190-2148, 0190-2148 KW - Carcinogens KW - 0 KW - DNA Primers KW - RNA, Messenger KW - Receptors, Transforming Growth Factor beta KW - TGFB1 protein, human KW - Tgfb1 protein, mouse KW - Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Animals KW - Humans KW - Carcinogens -- toxicity KW - Disease Models, Animal KW - Mice KW - Bronchi -- drug effects KW - Reverse Transcriptase Polymerase Chain Reaction KW - Bronchi -- pathology KW - Mice, Inbred A KW - Blotting, Western KW - In Situ Hybridization KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Mice, Inbred C57BL KW - Bronchi -- metabolism KW - Immunohistochemistry KW - Female KW - DNA Primers -- chemistry KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Adenoma -- metabolism KW - Adenoma -- chemically induced KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Lung Neoplasms -- chemically induced KW - Transforming Growth Factor beta -- genetics KW - Adenoma -- pathology KW - Transforming Growth Factor beta -- metabolism KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72532121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Transforming+growth+factor-beta+1+and+its+receptors+in+human+lung+cancer+and+mouse+lung+carcinogenesis.&rft.au=Kang%2C+Y%3BPrentice%2C+M+A%3BMariano%2C+J+M%3BDavarya%2C+S%3BLinnoila%2C+R+I%3BMoody%2C+T+W%3BWakefield%2C+L+M%3BJakowlew%2C+S+B&rft.aulast=Kang&rft.aufirst=Y&rft.date=2000-12-01&rft.volume=26&rft.issue=8&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers. AN - 72531250; 11180020 AB - St John's Wort is a popular herbal product used by approximately 7% of patients with epilepsy. Previous reports have described reductions in concentrations of CYP3A4 substrates indinavir and cyclosporine (INN, ciclosporin) associated with St John's Wort. Our objective was to determine the effect of St John's Wort on steady state carbamazepine and carbamazepine-10,11-epoxide pharmacokinetics. Eight healthy volunteers (5 men; age range, 24-43 years) participated in this unblinded study. Subjects received 100 mg of carbamazepine twice daily for 3 days, 200 mg twice daily for 3 days, and then 400 mg once daily for 14 days. Blood samples were collected before and 1, 2, 4, 6, 8, 10, 12, and 24 hours after the dose on day 21. The subjects then took 300 mg of St John's Wort (0.3% hypericin standardized tablet) 3 times daily with meals and with carbamazepine for 14 days. On day 35, blood sampling was repeated. Plasma samples were analyzed for carbamazepine and carbamazepine-10,11-epoxide with HPLC. We compared carbamazepine and carbamazepine-10,11-epoxide noncompartmental pharmacokinetic parameter values before and after St John's Wort with a paired Student t test. We found no significant differences before or after the administration of St John's Wort in carbamazepine peak concentration (7.2 +/- 1 mg/L before versus 7.6 +/- 1.3 mg/L after), trough concentration (4.8 +/- 0.5 mg/L before versus 4.3 +/- 0.8 mg/L after), area under the plasma concentration-time curve (142.4 +/- 12.9 mg x h/L before versus 143.8 +/- 27.2 mg x h/L after), or oral clearance (2.8 +/- 0.3 L/h before versus 2.9 +/- 0.6 L/h after). Similarly, no differences were found in peak concentration (2 +/- 0.5 mg/L before versus 2.1 +/- 0.4 mg/L after), trough concentration (1.3 +/- 0.3 mg/L before versus 1.4 +/- 0.3 mg/L after), and area under the plasma concentration-time curve (37.5 +/- 7.4 mg x h/L before versus 41.9 +/- 10.3 mg x h/L after) of carbamazepine-10,11-epoxide. The results suggest that treatment with St John's Wort for 14 days did not further induce the clearance of carbamazepine. JF - Clinical pharmacology and therapeutics AU - Burstein, A H AU - Horton, R L AU - Dunn, T AU - Alfaro, R M AU - Piscitelli, S C AU - Theodore, W AD - Clinical Center Pharmacy Department, Epilepsy Research Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. aburstein@nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 605 EP - 612 VL - 68 IS - 6 SN - 0009-9236, 0009-9236 KW - Anticonvulsants KW - 0 KW - Carbamazepine KW - 33CM23913M KW - carbamazepine epoxide KW - QC9505F279 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Interactions KW - Humans KW - Adult KW - Male KW - Carbamazepine -- pharmacokinetics KW - Anticonvulsants -- pharmacokinetics KW - Hypericum -- adverse effects KW - Plants, Medicinal KW - Carbamazepine -- blood KW - Carbamazepine -- analogs & derivatives KW - Anticonvulsants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72531250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Lack+of+effect+of+St+John%27s+Wort+on+carbamazepine+pharmacokinetics+in+healthy+volunteers.&rft.au=Burstein%2C+A+H%3BHorton%2C+R+L%3BDunn%2C+T%3BAlfaro%2C+R+M%3BPiscitelli%2C+S+C%3BTheodore%2C+W&rft.aulast=Burstein&rft.aufirst=A&rft.date=2000-12-01&rft.volume=68&rft.issue=6&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=00099236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2001-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. AN - 72529181; 11156228 AB - We have investigated the hypothesis that nitric oxide synthase (NOS2), cyclooxygenase-2 (COX2), and vascular endothelial growth factor (VEGF) protein levels individually demonstrate a direct correlation with microvessel density (MVD) and clinical outcome in human non-small cell lung cancer (NSCLC). Furthermore, we hypothesized that MVD may explain the propensity of certain histological lung cancer subtypes for early metastasis via a hematological route. Immunohistochemically, we studied the protein expression levels of NOS2, COX2, and VEGF and MVD by counting CD31-reactive blood vessels (BVs) in 106 surgically resected NSCLC specimens. NOS2, COX2, and VEGF immunoreactivity were observed in 48, 48, and 58%, respectively, of the study subjects, and their levels correlated with MVD at the tumor-stromal interphase (P < or = 0.001). More adenocarcindmas and large cell carcinomas displayed overexpression of NOS2 when compared with squamous cell carcinoma (SCC; r = 0.44; P < 0.001). NOS2 and COX2 levels were found to correlate positively with VEGF status (r = 0.44; P < 0.001, 0.01, and 0.03, respectively). These results attest to the significant interaction of these factors in the angiogenesis of NSCLC. Although neither angiogenic factors nor MVD correlated with patient survival, the latter correlated with tumor clinical stage in both squamous (SCC; 73 BVs/mm2) and non-SCC (78 BVs/mm2) tumors. These results indicate that angiogenesis is a complex process that involves multiple factors including NOS2, COX2, and VEGF. Furthermore, the role of angiogenesis in the biology of various histological lung cancer types may be different. The complexity of angiogenesis may explain the modest results observed in antiangiogenesis therapy that target a single protein. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Marrogi, A J AU - Travis, W D AU - Welsh, J A AU - Khan, M A AU - Rahim, H AU - Tazelaar, H AU - Pairolero, P AU - Trastek, V AU - Jett, J AU - Caporaso, N E AU - Liotta, L A AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 4739 EP - 4744 VL - 6 IS - 12 SN - 1078-0432, 1078-0432 KW - Endothelial Growth Factors KW - 0 KW - Isoenzymes KW - Lymphokines KW - Membrane Proteins KW - Vascular Endothelial Growth Factor A KW - Vascular Endothelial Growth Factors KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Prostaglandin-Endoperoxide Synthases KW - Index Medicus KW - Disease-Free Survival KW - Lymphatic Metastasis KW - Humans KW - Smoking KW - Cytoplasm -- metabolism KW - Microcirculation -- metabolism KW - Immunohistochemistry KW - Female KW - Male KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Lymphokines -- biosynthesis KW - Lung Neoplasms -- diagnosis KW - Endothelial Growth Factors -- biosynthesis KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Isoenzymes -- biosynthesis KW - Lung Neoplasms -- mortality KW - Neovascularization, Pathologic KW - Carcinoma, Non-Small-Cell Lung -- diagnosis KW - Prostaglandin-Endoperoxide Synthases -- biosynthesis KW - Nitric Oxide Synthase -- biosynthesis KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72529181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Nitric+oxide+synthase%2C+cyclooxygenase+2%2C+and+vascular+endothelial+growth+factor+in+the+angiogenesis+of+non-small+cell+lung+carcinoma.&rft.au=Marrogi%2C+A+J%3BTravis%2C+W+D%3BWelsh%2C+J+A%3BKhan%2C+M+A%3BRahim%2C+H%3BTazelaar%2C+H%3BPairolero%2C+P%3BTrastek%2C+V%3BJett%2C+J%3BCaporaso%2C+N+E%3BLiotta%2C+L+A%3BHarris%2C+C+C&rft.aulast=Marrogi&rft.aufirst=A&rft.date=2000-12-01&rft.volume=6&rft.issue=12&rft.spage=4739&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-19 N1 - Date created - 2001-01-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Cancer Res. 2000 Dec;6(12):4604-6 [11156208] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adenosine induced direct negative inotropic effect is abolished during global ischemia: role of protein kinase C and prostacyclin. AN - 72529162; 11133171 AB - Adenosine acts as a cardioprotective agent by producing coronary vasodilation, decreasing heart rate and by antagonizing the cardiostimulatory effect of catecholamines; adenosine also exerts a direct negative inotropic effect. Myocardial ischemia is known to be associated with enhanced levels of adenosine, increased protein kinase C (PKC) activity and prostacyclin (PGI2) release. The present study was conducted to determine if myocardial ischemia alters the cardioprotective effect of adenosine by increasing PKC activity and PGI2 release in the isolated rat heart perfused at 10 ml/min with Krebs-Henseleit buffer (KHB; 95% O2+5% CO2). Adenosine (10 mmol/min) reduced myocardial contractility as indicated by a decrease in contractility (dp/dtmax), heart rate (HR) and coronary perfusion pressure (PP). In hearts subjected to 30 min of ischemia (without perfusion) and then reperfused with KHB, adenosine failed to decrease dp/dtmax, HR or PP. However, during infusion of PKC inhibitor H-7 (1-(5-Isoquinolinesulfonyl)-2-methylpiperazine hydrochloride) (H-7; 6 mmol/min), which commenced 10 min before ischemia and continued throughout reperfusion, adenosine produced a decrease in dp/dtmax, HR and PP, similar to that before ischemia. Infusion of the PKC activator phorbol 12,13-dibutyrate (PDBu; 2 nmol/min) but not an inactive analogue in non-ischemic hearts prevented the adenosine induced decrease in dp/dtmax. During infusion of H-7, PDBu failed to block the direct negative inotropic effect of adenosine in non-ischemic hearts. In addition, pretreatment with H-7 or indomethacin (cyclooxygenase inhibitor) significantly reduced the PGI2 release following ischemia. This data suggest that PKC and PGI2 regulate the direct negative inotropic effect of adenosine, which is abolished during ischemia. JF - Prostaglandins, leukotrienes, and essential fatty acids AU - Oriji, G K AD - Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 343 EP - 349 VL - 63 IS - 6 SN - 0952-3278, 0952-3278 KW - Enzyme Inhibitors KW - 0 KW - Prostaglandin Antagonists KW - Vasodilator Agents KW - Phorbol 12,13-Dibutyrate KW - 37558-16-0 KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine KW - 84477-87-2 KW - Epoprostenol KW - DCR9Z582X0 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Adenosine KW - K72T3FS567 KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Rats KW - Animals KW - 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine -- pharmacology KW - Drug Interactions KW - Perfusion KW - Enzyme Activation -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Prostaglandin Antagonists -- pharmacology KW - Male KW - Phorbol 12,13-Dibutyrate -- pharmacology KW - Indomethacin -- pharmacology KW - Depression, Chemical KW - Protein Kinase C -- antagonists & inhibitors KW - Heart Rate -- drug effects KW - Adenosine -- pharmacology KW - Myocardial Ischemia -- metabolism KW - Epoprostenol -- physiology KW - Myocardial Contraction -- drug effects KW - Protein Kinase C -- physiology KW - Vasodilator Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72529162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.atitle=Adenosine+induced+direct+negative+inotropic+effect+is+abolished+during+global+ischemia%3A+role+of+protein+kinase+C+and+prostacyclin.&rft.au=Oriji%2C+G+K&rft.aulast=Oriji&rft.aufirst=G&rft.date=2000-12-01&rft.volume=63&rft.issue=6&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.issn=09523278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Biomedical research leaders: report on needs, opportunities, difficulties, education and training, and evaluation. AN - 72528584; 11121363 AB - The National Association of Physicians for the Environment (NAPE) has assumed a leadership role in protecting environmental health in recent years. The Committee of Biomedical Research Leaders was convened at the recent NAPE Leadership Conference: Biomedical Research and the Environment held on 1--2 November 1999, at the National Institutes of Health, Bethesda, Maryland. This report summarizes the discussion of the committee and its recommendations. The charge to the committee was to raise and address issues that will promote and sustain environmental health, safety, and energy efficiency within the biomedical community. Leaders from every important research sector (industry laboratories, academic health centers and institutes, hospitals and care facilities, Federal laboratories, and community-based research facilities) were gathered in this committee to discuss issues relevant to promoting environmental health. The conference and this report focus on the themes of environmental stewardship, sustainable development and "best greening practices." Environmental stewardship, an emerging theme within and outside the biomedical community, symbolizes the effort to provide an integrated, synthesized, and concerted effort to protect the health of the environment in both the present and the future. The primary goal established by the committee is to promote environmentally responsible leadership in the biomedical research community. Key outcomes of the committee's discussion and deliberation were a) the need for a central organization to evaluate, promote, and oversee efforts in environmental stewardship; and b) immediate need to facilitate efficient information transfer relevant to protecting the global environment through a database/clearinghouse. Means to fulfill these needs are discussed in this report. JF - Environmental health perspectives AU - Wilson, S H AU - Merkle, S AU - Brown, D AU - Moskowitz, J AU - Hurley, D AU - Bailey, B J AU - McClain, M AU - Misenhimer, M AU - Buckalew, J AU - Burks, T AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 979 EP - 995 VL - 108 Suppl 6 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Environmental Health KW - Humans KW - Public Policy KW - Leadership KW - Environmental Pollution -- prevention & control KW - Physician's Role KW - Biomedical Technology KW - Conservation of Natural Resources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72528584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Biomedical+research+leaders%3A+report+on+needs%2C+opportunities%2C+difficulties%2C+education+and+training%2C+and+evaluation.&rft.au=Wilson%2C+S+H%3BMerkle%2C+S%3BBrown%2C+D%3BMoskowitz%2C+J%3BHurley%2C+D%3BBailey%2C+B+J%3BMcClain%2C+M%3BMisenhimer%2C+M%3BBuckalew%2C+J%3BBurks%2C+T&rft.aulast=Wilson&rft.aufirst=S&rft.date=2000-12-01&rft.volume=108+Suppl+6&rft.issue=&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-09-20 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - K-ras p21 expression and activity in lung and lung tumors. AN - 72528075; 11195463 AB - Although K-ras is mutated in many human and mouse lung adenocarcinomas, the function of K-ras p21 in lung is not known. We sought evidence for the prevalent hypothesis that K-ras p21 activates raf, which in turn passes the signal through the extracellular signal regulated kinases (Erks) to stimulate cell division, and that this pathway is upregulated when K-ras is mutated. Results from both mouse lung tumors and immortalized cultured E10 and C10 lung type II cells failed to substantiate this hypothesis. Lung tumors did not have more total K-ras p21 or K-ras p21 GTP than normal lung tissue, nor were high levels of these proteins found in tumors with mutant K-ras. Activated K-ras p21-GTP levels did not correlate with proliferating cell nuclear antigen. Special features of tumors with mutant K-ras included small size of carcinomas compared with carcinomas lacking this mutation, and correlation of proliferating cell nuclear antigen with raf-1. In nontransformed type II cells in culture, both total and activated K-ras p21 increased markedly at confluence but not after serum stimulation, whereas both Erk1/2 and the protein kinase Akt were rapidly activated by the serum treatment. Reverse transcriptase-polymerase chain reaction (RT-PCR) assays of K-ras mRNA indicated an increase in confluent and especially in postconfluent cells. Together the findings indicate that normal K-ras p21 activity is associated with growth arrest of lung type II cells, and that the exact contribution of mutated K-ras p21 to tumor development remains to be discovered. JF - Experimental lung research AU - Ramakrishna, G AU - Sithanandam, G AU - Cheng, R Y AU - Fornwald, L W AU - Smith, G T AU - Diwan, B A AU - Anderson, L M AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, Maryland, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 659 EP - 671 VL - 26 IS - 8 SN - 0190-2148, 0190-2148 KW - Proliferating Cell Nuclear Antigen KW - 0 KW - RNA, Messenger KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Epithelial Cells -- metabolism KW - Animals KW - Pulmonary Alveoli -- metabolism KW - RNA, Messenger -- analysis KW - Pulmonary Alveoli -- cytology KW - Mice KW - Cell Line, Transformed KW - Reverse Transcriptase Polymerase Chain Reaction KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Genes, ras KW - Gene Expression Regulation, Neoplastic KW - Proto-Oncogene Proteins p21(ras) -- metabolism KW - Adenocarcinoma -- metabolism KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Lung -- metabolism KW - Proto-Oncogene Proteins p21(ras) -- genetics KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72528075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=K-ras+p21+expression+and+activity+in+lung+and+lung+tumors.&rft.au=Ramakrishna%2C+G%3BSithanandam%2C+G%3BCheng%2C+R+Y%3BFornwald%2C+L+W%3BSmith%2C+G+T%3BDiwan%2C+B+A%3BAnderson%2C+L+M&rft.aulast=Ramakrishna&rft.aufirst=G&rft.date=2000-12-01&rft.volume=26&rft.issue=8&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental transmission of DSM-IV substance use disdorders in adoptive and step families. AN - 72527941; 11141037 AB - One factor contributing to the 3- to 5-fold increase in risk for substance use disorders (SUDs) among children of alcoholics may be the rearing environment. These influences may include availability of substances, modeling of SUDs, inadequate parenting, or other factors. The contribution of parental environmental influences on offspring with SUDs may be estimated independently of genetic influences through assessment of adoptees raised by nonbiological parents. Relative risk of SUDs was assessed in adult adoptees (N = 442) of alcoholic and nonalcoholic adoptive parents as well as in stepchildren (N = 1859) with alcoholic or nonalcoholic stepfathers who participated in the community-based National Longitudinal Alcohol Epidemiologic Survey (NLAES). Rearing by an alcoholic adoptive mother was associated with increased DSM-IV alcohol abuse. Rearing by an alcoholic adoptive father was predictive of adoptees' illicit drug use, as well as DSM-IV drug dependence. Rearing by an alcoholic stepfather was predictive of stepchild DSM-IV alcohol abuse, illicit drug use, and drug dependence, whereas an alcoholic stepmother was associated with increased illicit drug use in the stepchild. Alcoholism in adoptive parents or step parents did not increase risk for offspring DSM-IV alcohol dependence. In both adoptive and biological families, there was a subadditive interaction of mother by father alcoholism such that the rate of substance abuse when both parents were alcoholic was less than that expected based on the additive effects of each alcoholic parent. Rearing by an alcoholic parent had a greater influence on alcohol abuse by offspring than on alcohol dependence. The increased risk of proband illicit drug use and drug dependence associated with paternal alcoholism suggested nonspecificity of environmental transmission. Both maternal and paternal cultural transmission effects influenced offspring SUDs. JF - Alcoholism, clinical and experimental research AU - Newlin, D B AU - Miles, D R AU - van den Bree, M B AU - Gupman, A E AU - Pickens, R W AD - Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA. dnewlin@intra.nida.nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1785 EP - 1794 VL - 24 IS - 12 SN - 0145-6008, 0145-6008 KW - Street Drugs KW - 0 KW - Index Medicus KW - United States KW - Risk KW - Genetic Predisposition to Disease -- genetics KW - Humans KW - Health Surveys KW - Adult KW - Substance-Related Disorders -- psychology KW - Longitudinal Studies KW - Adolescent KW - Substance-Related Disorders -- genetics KW - Male KW - Female KW - Child of Impaired Parents -- psychology KW - Adoption -- psychology KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Social Environment KW - Parents -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72527941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Environmental+transmission+of+DSM-IV+substance+use+disdorders+in+adoptive+and+step+families.&rft.au=Newlin%2C+D+B%3BMiles%2C+D+R%3Bvan+den+Bree%2C+M+B%3BGupman%2C+A+E%3BPickens%2C+R+W&rft.aulast=Newlin&rft.aufirst=D&rft.date=2000-12-01&rft.volume=24&rft.issue=12&rft.spage=1785&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Morphometric analysis of CC10-hASH1 transgenic mouse lung: a model for bronchiolization of alveoli and neuroendocrine carcinoma. AN - 72527787; 11195458 AB - Constitutive expression of human achaete-scute homolog-1 (hASH1) alone or in combination with Simian virus 40 (SV40) large T antigen (TAg) under the Clara cell 10-kDa secretory protein (CC10) promoter results in bronchiolization of alveoli and enhanced tumorigenesis, respectively. A novel morphometric system composed of series of fixed distance concentric rings originating at the bronchioloalveolar junction was used to determine spatial growth patterns. hASH1 mice exhibited progressive airway epithelial hyperplasia near this junction, and minimal changes further away in the alveolar compartment. TAg animals shared this increase, but exhibited variable distance-dependent growth. By 2 months TAg/hASH1 animals showed highly increased growth at all points measured. Remarkably, TAg/hASH1 animals expressed both CC10 and extensive neuroendocrine differentiation in airways and tumors. The results suggest that these transgenic mice provide a useful model with many similarities to human lung carcinogenesis, which originates in airway epithelium, and often reveals neuroendocrine differentiation. JF - Experimental lung research AU - Linnoila, R I AU - Sahu, A AU - Miki, M AU - Ball, D W AU - DeMayo, F J AD - Cell and Cancer Biology Department, Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Institute of Health, 9610 Medical Center Drive, Suite 300, Rockville, MD 20850, USA. il17h@nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 595 EP - 615 VL - 26 IS - 8 SN - 0190-2148, 0190-2148 KW - ASCL1 protein, human KW - 0 KW - Antigens, Polyomavirus Transforming KW - Ascl1 protein, mouse KW - Basic Helix-Loop-Helix Transcription Factors KW - Biomarkers, Tumor KW - DNA Primers KW - DNA-Binding Proteins KW - Proteins KW - RNA, Neoplasm KW - SCGB1A1 protein, human KW - Scgb1a1 protein, mouse KW - Transcription Factors KW - Uteroglobin KW - 9060-09-7 KW - Index Medicus KW - Pulmonary Alveoli -- pathology KW - Animals KW - Hyperplasia -- pathology KW - Humans KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Neoplasm -- analysis KW - Bronchi -- pathology KW - Biomarkers, Tumor -- metabolism KW - Pulmonary Alveoli -- metabolism KW - Metaplasia -- pathology KW - Bronchi -- metabolism KW - Image Processing, Computer-Assisted KW - Immunoenzyme Techniques KW - DNA Primers -- chemistry KW - Carcinoma, Neuroendocrine -- pathology KW - Transcription Factors -- metabolism KW - DNA-Binding Proteins -- genetics KW - Disease Models, Animal KW - Lung -- metabolism KW - Lung -- pathology KW - Mice, Transgenic KW - Transcription Factors -- genetics KW - Proteins -- metabolism KW - Proteins -- genetics KW - Carcinoma, Neuroendocrine -- genetics KW - Carcinoma, Neuroendocrine -- metabolism KW - Lung Neoplasms -- genetics KW - DNA-Binding Proteins -- metabolism KW - Lung Neoplasms -- metabolism KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72527787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Morphometric+analysis+of+CC10-hASH1+transgenic+mouse+lung%3A+a+model+for+bronchiolization+of+alveoli+and+neuroendocrine+carcinoma.&rft.au=Linnoila%2C+R+I%3BSahu%2C+A%3BMiki%2C+M%3BBall%2C+D+W%3BDeMayo%2C+F+J&rft.aulast=Linnoila&rft.aufirst=R&rft.date=2000-12-01&rft.volume=26&rft.issue=8&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic acidosis and hyperventilation induced by acetazolamide in patients with central nervous system pathology. AN - 72527262; 11149457 JF - Anesthesiology AU - Venkatesha, S L AU - Umamaheswara Rao, G S AD - Department of Neuroanaesthesia, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1546 EP - 1548 VL - 93 IS - 6 SN - 0003-3022, 0003-3022 KW - Carbonic Anhydrase Inhibitors KW - 0 KW - Acetazolamide KW - O3FX965V0I KW - Abridged Index Medicus KW - Index Medicus KW - Hematoma, Subdural -- surgery KW - Neurocysticercosis -- complications KW - Humans KW - Adult KW - Respiration -- drug effects KW - Headache -- drug therapy KW - Hematoma, Subdural -- metabolism KW - Headache -- etiology KW - Craniocerebral Trauma -- surgery KW - Craniocerebral Trauma -- metabolism KW - Male KW - Female KW - Hyperventilation -- chemically induced KW - Acetazolamide -- adverse effects KW - Acidosis -- chemically induced KW - Carbonic Anhydrase Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72527262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=Metabolic+acidosis+and+hyperventilation+induced+by+acetazolamide+in+patients+with+central+nervous+system+pathology.&rft.au=Venkatesha%2C+S+L%3BUmamaheswara+Rao%2C+G+S&rft.aulast=Venkatesha&rft.aufirst=S&rft.date=2000-12-01&rft.volume=93&rft.issue=6&rft.spage=1546&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=00033022&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of p53 transgenic mice in the development of cancer models for multiple purposes. AN - 72525984; 11195457 AB - The tumor suppressor gene p53 is perhaps the most commonly mutated gene in human cancer, being mutated in a high percentage of colon, breast, skin, bladder, and many cancers of the aerodigestive tract. Individuals with Li-Fraumeni syndrome, who routinely have a germline mutation in the p53 tumor suppressor gene, are at high risk for lung cancer, confirming its intimate role in lung tumorigenesis in humans. In contrast, the majority of chemically induced or spontaneous cancers in rodents do not contain mutations in p53. Therefore, we examined a transgenic mouse that contains a dominant negative mutation (Arg135Val) in the p53 gene placed under the control of its own endogenous promoter. The resulting mice have 3 copies of the mutated transgene as well as 2 normal p53 alleles. In the chemical carcinogenesis studies, we employed mice containing the mutated p53 gene to examine for carcinogen susceptibility. We found that mice with the p53 mutation, on an A/J F1 background, were more susceptible to a number of potential lung carcinogens, including N-methyl-N-nitrosourea (MNU) and the known tobacco carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo(a)pyrene (BP). Mice with a mutant p53 developed larger tumors and roughly 3 times as many tumors, emphasizing the potential effects of a p53 mutation both on tumor initiation and progression. In addition, we examined 2 nonlung carcinogens, 1,2-dimethylhydrazine (DMH), a colon carcinogen, and N-butyl-N-(4-hydroxybutyl)-nitrosamine (OHBBN), a bladder carcinogen. Interestingly a germline p53 mutation increased the incidence of DMH-induced colon, lung, hepatic, and uterine tumors, while having limited effects on OHBBN-induced bladder tumors. Because of its heightened susceptibility we are examining the use of this model in smoke-induced tumorigenesis in A/J mice as well. Employing the lung adenomas induced by NNK, we found that mice with or without a p53 mutation were equally susceptible to the chemopreventive effects of dexamethasone plus myo-inisitol and green tea. These tumors, which arise in a highly reproducible manner in p53 transgenic mice following carcinogen treatment, have mutations in both p53 and the K-ras oncogene. Thus, this model appears useful for examining for potential chemotherapeutic agents. p53-mutated or wild-type mice were equally susceptible to the therapeutic effects of Taxol or Adriamycin. Interestingly, piroxicam was similarly effective in inhibiting colon tumor formation by DMH in mice with or without a mutation in the p53 tumor suppressor gene. In contrast, lung and uterine tumors developing in these mice were not susceptible to the chemopreventive effects of piroxicam. In summary, mice with mutations in the p53 tumor suppressor gene appear to be particularly applicable for basic mechanistic studies, for screening for potential carcinogens, and for screening for chemopreventive or chemotherapeutic agents. JF - Experimental lung research AU - Lubet, R A AU - Zhang, Z AU - Wiseman, R W AU - You, M AD - Chemoprevention Branch, National Cancer Institute, Executive Plaza North, Room 201, 6130 Executive Boulevard, Bethesda, MD 20852, USA. rl578@nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 581 EP - 593 VL - 26 IS - 8 SN - 0190-2148, 0190-2148 KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Mutation KW - Genes, p53 KW - Neoplasms, Experimental -- chemically induced KW - Neoplasms, Experimental -- genetics KW - Disease Models, Animal KW - Neoplasms, Experimental -- prevention & control KW - Neoplasms, Experimental -- drug therapy KW - Genetic Predisposition to Disease KW - Mice, Transgenic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72525984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+lung+research&rft.atitle=Use+of+p53+transgenic+mice+in+the+development+of+cancer+models+for+multiple+purposes.&rft.au=Lubet%2C+R+A%3BZhang%2C+Z%3BWiseman%2C+R+W%3BYou%2C+M&rft.aulast=Lubet&rft.aufirst=R&rft.date=2000-12-01&rft.volume=26&rft.issue=8&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Experimental+lung+research&rft.issn=01902148&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - US low-risk drinking guidelines: an examination of four alternatives. AN - 72523829; 11141041 AB - This study compared four sets of US low-risk drinking guidelines (two interpretations of the US Dietary Guidelines and two variations of the NIAAA physicians' guidelines) in terms of adherence and how well they predicted five different alcohol-related outcomes. Using data from a nationally representative sample of 17,542 US adults 21 years of age and over who drank 12 or more drinks in the past year, this study assessed the sensitivity, specificity, overall accuracy, positive and negative predictive values, and odds ratios of the various drinking guidelines (specifically, of having exceeded them with different degrees of frequency) as predictors of alcohol dependence, impaired driving, liver disease, peptic ulcer, and hypertension. The proportions of past-year regular drinkers exceeding the four sets of guidelines varied from 20.9%, whose average intake exceeded the weekly limits, to between 21.0% and 42.7% who exceeded the daily guidelines at least once a week, and to between 69.2% and 94.2% who ever exceeded the daily limits in the year preceding the interview. Sensitivity and odds ratios were highest for the ever exceeding the Dietary Guidelines daily limits, intermediate for ever exceeding the two variations based on the NIAAA physicians' guidelines, and lowest for exceeding the Dietary Guidelines interpreted as weekly limits. The opposite pattern was observed for specificity and overall predictive accuracy. When frequently exceeding the daily limits was considered, their sensitivity declined but their specificity and positive predictive value increased. If sensitivity and specificity are deemed equally important, the NIAAA physicians' guidelines incorporating both daily and weekly limits seem to do the best job of balancing these dimensions in the prediction of a variety of alcohol-related outcomes. JF - Alcoholism, clinical and experimental research AU - Dawson, D A AD - Division of Biometry and Epidemiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-7003, USA. ddawson@sillco.niaaa.nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1820 EP - 1829 VL - 24 IS - 12 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Sensitivity and Specificity KW - Odds Ratio KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Guidelines as Topic KW - Longitudinal Studies KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Alcohol Drinking -- adverse effects KW - Alcohol Drinking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72523829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=US+low-risk+drinking+guidelines%3A+an+examination+of+four+alternatives.&rft.au=Dawson%2C+D+A&rft.aulast=Dawson&rft.aufirst=D&rft.date=2000-12-01&rft.volume=24&rft.issue=12&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-15 N1 - Date created - 2001-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Micronucleus frequencies in exfoliated buccal cells in normal mucosa, precancerous lesions and squamous cell carcinoma. AN - 72521705; 11147304 AB - To assess the value of micronuclei in the characterization of precancerous lesions of the oral cavity with reference to their likelihood of progressing to malignant lesions. The frequency of micronuclei was determined in exfoliated cells from normal oral mucosa, a preneoplastic condition (leukoplakia) and precancerous lesions with and without dysplasia, squamous cell carcinomas and sites of previous carcinomas that had been removed. Average micronucleus frequencies were increased in precancerous lesions as compared to normal mucosa and further increased in carcinomas, suggesting that micronuclei are a biomarker of neoplastic progression in this type of cancer. With all samples, micronucleus frequencies were systematically higher when cells were collected by vigorous than by light scraping, suggesting a decreasing gradient from basal to superficial layers of mucosa. The micronucleus frequency did not vary with the sex or age of patients, while it did vary with the anatomic site of the lesions. Although the gradual increase in micronucleus counts from normal mucosa to precancerous lesions to carcinomas suggests a link of this biomarker with neoplastic progression, the large overlapping of data prevents its use as a predictor of progression of precancerous lesions to malignancy in individual patients. JF - Analytical and quantitative cytology and histology AU - Casartelli, G AU - Bonatti, S AU - De Ferrari, M AU - Scala, M AU - Mereu, P AU - Margarino, G AU - Abbondandolo, A AD - Mutagenesis Laboratory, National Cancer Institute-Genoa, Genoa, Italy. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 486 EP - 492 VL - 22 IS - 6 SN - 0884-6812, 0884-6812 KW - Index Medicus KW - Cheek -- anatomy & histology KW - Reproducibility of Results KW - Humans KW - Leukoplakia, Oral -- pathology KW - Prognosis KW - Disease Progression KW - Aged KW - Predictive Value of Tests KW - Cheek -- pathology KW - Leukoplakia, Oral -- epidemiology KW - Erythroplasia -- epidemiology KW - Aged, 80 and over KW - Erythroplasia -- pathology KW - Adult KW - Incidence KW - Middle Aged KW - Male KW - Female KW - Carcinoma, Squamous Cell -- epidemiology KW - Mouth Mucosa -- pathology KW - Micronuclei, Chromosome-Defective -- pathology KW - Carcinoma, Squamous Cell -- pathology KW - Mouth Neoplasms -- pathology KW - Mouth Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72521705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+quantitative+cytology+and+histology&rft.atitle=Micronucleus+frequencies+in+exfoliated+buccal+cells+in+normal+mucosa%2C+precancerous+lesions+and+squamous+cell+carcinoma.&rft.au=Casartelli%2C+G%3BBonatti%2C+S%3BDe+Ferrari%2C+M%3BScala%2C+M%3BMereu%2C+P%3BMargarino%2C+G%3BAbbondandolo%2C+A&rft.aulast=Casartelli&rft.aufirst=G&rft.date=2000-12-01&rft.volume=22&rft.issue=6&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=Analytical+and+quantitative+cytology+and+histology&rft.issn=08846812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stem-cell transplantation for inherited immunodeficiency disorders. AN - 72511935; 11131001 AB - For patients with well-characterized, rapidly fatal, nonmalignant immunodeficiency disorders, such as SCID, the decision to proceed with allogeneic SCT is clear-cut. For patients with many other disorders, this decision can be extremely difficult. Disorders such as LAD or CGD have a variable natural history. Each patient must be considered individually, with the risk for SCT-related morbidity and mortality carefully weighed against that of the underlying disease. Significant advances during the past 10 years have made SCT a much safer procedure. Use of nonmyeloablative conditioning regimens as a means of reducing toxicity of high-dose chemotherapy and irradiation hold great promise. Highly immunosuppressive, nonchemotherapeutic agents that inhibit graft rejection or GVHD by blocking the critical costimulatory component of the T-cell receptor-antigen interaction are beginning to emerge and may be ideal for SCT of nonmalignant diseases. Therefore, the risk-benefit equation must be reassessed each year as the severity of patients' disorders is better defined and techniques of SCT improve. JF - Pediatric clinics of North America AU - Horwitz, M E AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1371 EP - 1387 VL - 47 IS - 6 SN - 0031-3955, 0031-3955 KW - Abridged Index Medicus KW - Index Medicus KW - Infant KW - Humans KW - Treatment Outcome KW - Prognosis KW - Infant, Newborn KW - Genetic Diseases, Inborn -- diagnosis KW - Child KW - Genetic Diseases, Inborn -- therapy KW - Male KW - Female KW - Child, Preschool KW - Immunologic Deficiency Syndromes -- diagnosis KW - Immunologic Deficiency Syndromes -- therapy KW - Immunologic Deficiency Syndromes -- genetics KW - Hematopoietic Stem Cell Transplantation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72511935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+clinics+of+North+America&rft.atitle=Stem-cell+transplantation+for+inherited+immunodeficiency+disorders.&rft.au=Horwitz%2C+M+E&rft.aulast=Horwitz&rft.aufirst=M&rft.date=2000-12-01&rft.volume=47&rft.issue=6&rft.spage=1371&rft.isbn=&rft.btitle=&rft.title=Pediatric+clinics+of+North+America&rft.issn=00313955&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bilateral median neuropathy and growth hormone use: a case report. AN - 72509567; 11128896 AB - A male elite bodybuilder suffered bilateral median nerve neuropathy during a self-administered course of growth hormone (GH). Nerve conduction velocities revealed bilateral median neuropathy consistent with carpal tunnel syndrome (CTS). This is the first case of GH-induced CTS occurring in an athlete. Contrary to earlier studies, this report demonstrates that GH-induced CTS is not an age-related phenomenon and alerts physicians to include GH abuse as a possible etiology of median neuropathy in athletes. JF - Archives of physical medicine and rehabilitation AU - Dickerman, R D AU - Douglas, J A AU - East, J W AD - Surgical Neurology Branch, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1594 EP - 1595 VL - 81 IS - 12 SN - 0003-9993, 0003-9993 KW - Growth Hormone KW - 9002-72-6 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Self Medication KW - Growth Hormone -- adverse effects KW - Carpal Tunnel Syndrome -- diagnosis KW - Carpal Tunnel Syndrome -- chemically induced KW - Weight Lifting KW - Carpal Tunnel Syndrome -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72509567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+physical+medicine+and+rehabilitation&rft.atitle=Bilateral+median+neuropathy+and+growth+hormone+use%3A+a+case+report.&rft.au=Dickerman%2C+R+D%3BDouglas%2C+J+A%3BEast%2C+J+W&rft.aulast=Dickerman&rft.aufirst=R&rft.date=2000-12-01&rft.volume=81&rft.issue=12&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=Archives+of+physical+medicine+and+rehabilitation&rft.issn=00039993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of exposure-time-response relationships using a spline weight function. AN - 72503874; 11129467 AB - To examine the time-dependent effects of exposure histories on disease, we estimate a weight function within a generalized linear model. The shape of the weight function, which is modeled as a cubic B-spline, gives information about the impact of exposure increments at different times on disease risk. The method is evaluated in a simulation study and is applied to data on smoking histories and lung cancer from a recent case-control study in Germany. JF - Biometrics AU - Hauptmann, M AU - Wellmann, J AU - Lubin, J H AU - Rosenberg, P S AU - Kreienbrock, L AD - GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany. hauptmann@nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1105 EP - 1108 VL - 56 IS - 4 SN - 0006-341X, 0006-341X KW - Index Medicus KW - Probability KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Germany KW - Time Factors KW - Lung Neoplasms -- epidemiology KW - Biometry -- methods KW - Epidemiologic Methods KW - Inhalation Exposure KW - Smoking -- adverse effects KW - Models, Statistical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72503874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Analysis+of+exposure-time-response+relationships+using+a+spline+weight+function.&rft.au=Hauptmann%2C+M%3BWellmann%2C+J%3BLubin%2C+J+H%3BRosenberg%2C+P+S%3BKreienbrock%2C+L&rft.aulast=Hauptmann&rft.aufirst=M&rft.date=2000-12-01&rft.volume=56&rft.issue=4&rft.spage=1105&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distinguishing effects on tumor multiplicity and growth rate in chemoprevention experiments. AN - 72503006; 11129462 AB - In some types of cancer chemoprevention experiments and short-term carcinogenicity bioassays, the data consist of the number of observed tumors per animal and the times at which these tumors were first detected. In such studies, there is interest in distinguishing between treatment effects on the number of tumors induced by a known carcinogen and treatment effects on the tumor growth rate. Since animals may die before all induced tumors reach a detectable size, separation of these effects can be difficult. This paper describes a flexible parametric model for data of this type. Under our model, the tumor detection times are realizations of a delayed Poisson process that is characterized by the age-specific tumor induction rate and a random latency interval between tumor induction and detection. The model accommodates distinct treatment and animal-specific effects on the number of induced tumors (multiplicity) and the time to tumor detection (growth rate). A Gibbs sampler is developed for estimation of the posterior distributions of the parameters. The methods are illustrated through application to data from a breast cancer chemoprevention experiment. JF - Biometrics AU - Dunson, D B AU - Dinse, G E AD - Biostatistics Branch, MD A3-03, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, North Carolina 27709, USA. dunson1@niehs.nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1068 EP - 1075 VL - 56 IS - 4 SN - 0006-341X, 0006-341X KW - Anticarcinogenic Agents KW - 0 KW - Vitamin A KW - 11103-57-4 KW - retinol acetate KW - 3LE3D9D6OY KW - Canthaxanthin KW - 4C3C6403MU KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Index Medicus KW - Rats KW - Mammary Neoplasms, Experimental -- chemically induced KW - Animals KW - Rats, Sprague-Dawley KW - Biometry -- methods KW - Models, Statistical KW - Canthaxanthin -- therapeutic use KW - Mammary Neoplasms, Experimental -- prevention & control KW - Female KW - Mammary Neoplasms, Experimental -- pathology KW - Vitamin A -- therapeutic use KW - Vitamin A -- analogs & derivatives KW - Anticarcinogenic Agents -- therapeutic use KW - Neoplasms, Experimental -- prevention & control KW - Neoplasms, Experimental -- pathology KW - Drug Screening Assays, Antitumor -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72503006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Distinguishing+effects+on+tumor+multiplicity+and+growth+rate+in+chemoprevention+experiments.&rft.au=Dunson%2C+D+B%3BDinse%2C+G+E&rft.aulast=Dunson&rft.aufirst=D&rft.date=2000-12-01&rft.volume=56&rft.issue=4&rft.spage=1068&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activity of a novel camptothecin analogue, homocamptothecin, in camptothecin-resistant cell lines with topoisomerase I alterations. AN - 72490870; 11118036 AB - Homocamptothecin (hCPT), which differs from camptothecin (CPT) by the presence of an additional methylene group in the E-ring, was evaluated in CPT-resistant cell lines. Topoisomerase I (top1)-deficient leukemia P388/CPT45 cells were highly resistant to hCPT, which demonstrates that top1 is the primary target of hCPT. Three CPT-resistant cell lines with top1 point mutations (Chinese hamster lung fibroblast DC3F/C10, human prostate carcinoma DU-145/RC1, and human leukemia CEM/C2) and their top1 enzymes were cross-resistant to hCPT. The antiproliferative activity of hCPT was greater than that of CPT in both parental and CPT-resistant cell lines, particularly in the prostate cell lines. The top1 cleavage complexes formed in the presence of hCPT appear to be more stable than those induced by CPT. Together, these data indicate that hCPT is a specific top1 inhibitor, which shares a common binding site with CPT in the topl-DNA cleavage complexes. Because of its potency, hCPT might overcome resistance to CPT in some cancer cells. JF - Cancer research AU - Urasaki, Y AU - Takebayashi, Y AU - Pommier, Y AD - Laboratory of Molecular Pharmacology, Division of Baisic Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 6577 EP - 6580 VL - 60 IS - 23 SN - 0008-5472, 0008-5472 KW - Antineoplastic Agents KW - 0 KW - DNA, Neoplasm KW - Enzyme Inhibitors KW - Topoisomerase I Inhibitors KW - homocamptothecin KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Animals KW - Drug Screening Assays, Antitumor KW - Leukemia P388 -- drug therapy KW - Humans KW - Prostatic Neoplasms -- genetics KW - Leukemia P388 -- enzymology KW - Mice KW - Drug Resistance, Neoplasm KW - Prostatic Neoplasms -- drug therapy KW - Leukemia P388 -- genetics KW - Tumor Cells, Cultured KW - Point Mutation KW - Enzyme Stability -- drug effects KW - Prostatic Neoplasms -- enzymology KW - Inhibitory Concentration 50 KW - DNA, Neoplasm -- metabolism KW - Male KW - Cricetinae KW - Camptothecin -- pharmacology KW - Camptothecin -- analogs & derivatives KW - Enzyme Inhibitors -- pharmacology KW - DNA Topoisomerases, Type I -- genetics KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72490870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Activity+of+a+novel+camptothecin+analogue%2C+homocamptothecin%2C+in+camptothecin-resistant+cell+lines+with+topoisomerase+I+alterations.&rft.au=Urasaki%2C+Y%3BTakebayashi%2C+Y%3BPommier%2C+Y&rft.aulast=Urasaki&rft.aufirst=Y&rft.date=2000-12-01&rft.volume=60&rft.issue=23&rft.spage=6577&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential DNA damage in response to the neonatal and adult excitotoxic hippocampal lesion in rats. AN - 72485569; 11122353 AB - We examined the developmental profile of excitotoxin-induced nuclear DNA fragmentation using the transferase dUTP nick-end labelling (TUNEL) technique, as a marker of DNA damage and cell death in rats with neonatal and adult excitotoxic lesions of the ventral hippocampus. We hypothesized that infusion of neurotoxin may result in a differential pattern of cell death in neonatally and adult lesioned rats, both in the infusion site and in remote brain regions presumably involved in mediating behavioural changes observed in these animals. Brains of rats lesioned at 7 days of age and in adulthood were collected at several survival times 1-21 days after the lesion. In the lesioned neonates 1-3 days postlesion, marked increases in TUNEL-positive cells occurred in the ventral hippocampus, the site of neurotoxin infusion, and in a wide surrounding area. Adult lesioned brains showed more positive cells than controls only at the infusion site. In the lesioned neonates, TUNEL-labelled cells were also present in the striatum and nucleus accumbens 1 day postlesion but not at later survival times. Our findings indicate that cell death in remote regions is more prominent in immature than adult brains, that it may lead to distinct alterations in development of these brain regions, and thus may be responsible for functional differences between neonatally and adult lesioned rats. JF - The European journal of neuroscience AU - Khaing, Z Z AU - Weickert, C S AU - Weinberger, D R AU - Lipska, B K AD - National Institute of Mental Health, IRP, Clinical Brain Disorders Branch, Building 10, Room 4N306, Bethesda, MD 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 4424 EP - 4433 VL - 12 IS - 12 SN - 0953-816X, 0953-816X KW - Ibotenic Acid KW - 2552-55-8 KW - Index Medicus KW - Animals KW - Nucleus Accumbens -- drug effects KW - Prefrontal Cortex -- physiology KW - Nucleus Accumbens -- pathology KW - Prefrontal Cortex -- drug effects KW - Rats KW - Animals, Newborn KW - In Situ Nick-End Labeling KW - Rats, Sprague-Dawley KW - Corpus Striatum -- physiology KW - Prefrontal Cortex -- pathology KW - Nucleus Accumbens -- physiology KW - Apoptosis -- drug effects KW - Corpus Striatum -- drug effects KW - Corpus Striatum -- pathology KW - DNA Fragmentation KW - Aging -- physiology KW - Hippocampus -- physiology KW - DNA Damage KW - Hippocampus -- pathology KW - Ibotenic Acid -- toxicity KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72485569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Differential+DNA+damage+in+response+to+the+neonatal+and+adult+excitotoxic+hippocampal+lesion+in+rats.&rft.au=Khaing%2C+Z+Z%3BWeickert%2C+C+S%3BWeinberger%2C+D+R%3BLipska%2C+B+K&rft.aulast=Khaing&rft.aufirst=Z&rft.date=2000-12-01&rft.volume=12&rft.issue=12&rft.spage=4424&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2001-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DNA damage in brain mitochondria caused by aging and MPTP treatment. AN - 72483665; 11121528 AB - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment leads to marked depletion of dopamine (DA) levels in the nigrostriatal pathway and dopaminergic neuronal degeneration in caudate-putamen and substantia nigra. MPTP is believed to inhibit complex I of the electron transport system leading to the generation of reactive oxygen species. We sought to test the hypotheses that MPTP treatment: (1) leads to dopamine depletion; (2) causes extensive mitochondrial DNA damage, and (3) that these effects would be age dependent. The levels of dopamine and its metabolites, DOPAC and HVA were analyzed by HPLC equipped with electrochemical detection. DNA damage was measured by quantitative PCR in both mitochondrial and nuclear (beta-polymerase) targets from the caudate-putamen, substantia nigra and cerebellum regions of control and MPTP-treated mice. The age groups studied were 22 days and 12 months. MPTP produced no significant effect on the levels of dopamine and its metabolites in young mice whereas in old, there was a significant decrease in this neurotransmitter system after MPTP administration. These 12-month-old mice, when compared to the young mice, showed a significant increase in mitochondrial DNA damage in the caudate-putamen and cerebellum. The latter region also displayed a significant increase in DNA damage in a nuclear gene. After treatment with MPTP, there was an age-dependent increase in DNA damage in mitochondria of the caudate-putamen while there was no significant DNA damage in the nuclear target. MPTP treatment led to damage in both mitochondrial and nuclear DNA of the substantia nigra, while there was no damage in either mitochondria or nucleus in cerebellum which was used as a negative control. JF - Brain research AU - Mandavilli, B S AU - Ali, S F AU - Van Houten, B AD - Laboratory of Molecular Genetics, National Institute of Environmental and Health Sciences, 111 Alexander Drive, Box 12233, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 45 EP - 52 VL - 885 IS - 1 SN - 0006-8993, 0006-8993 KW - DNA, Mitochondrial KW - 0 KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Homovanillic Acid -- analysis KW - DNA, Mitochondrial -- drug effects KW - Age Factors KW - Brain Chemistry -- drug effects KW - 3,4-Dihydroxyphenylacetic Acid -- analysis KW - Mice, Inbred C57BL KW - Dopamine -- analysis KW - Oxidative Stress -- genetics KW - Mice KW - Male KW - DNA, Mitochondrial -- genetics KW - DNA Damage -- physiology KW - Mitochondria -- drug effects KW - Mitochondria -- genetics KW - Aging -- genetics KW - MPTP Poisoning -- physiopathology KW - MPTP Poisoning -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72483665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=DNA+damage+in+brain+mitochondria+caused+by+aging+and+MPTP+treatment.&rft.au=Mandavilli%2C+B+S%3BAli%2C+S+F%3BVan+Houten%2C+B&rft.aulast=Mandavilli&rft.aufirst=B&rft.date=2000-12-01&rft.volume=885&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Age-dependent cytokine responses: trimethyltin hippocampal injury in wild-type, APOE knockout, and APOE4 mice. AN - 72479827; 11120597 AB - In this study, the hippocampal neurotoxicant trimethyltin (TMT) was used to examine possible differential susceptibility associated with the apolipoprotein E genotype. Mice-wild type (C57BL6J), APOE knockout, and APOE4 transgenic-received either saline or TMT (2 mg/kg, ip) at either 21 days or 8 months of age. At both ages, similar mRNA levels were seen in the hippocampus across genotypes for ICAM-1, A20, and MAC-1. GFAP mRNA was higher in the APOE knockouts and APOE4 as compared to wild-type mice. Within 24 h, TMT produced cell death of hippocampal dentate granule neurons and mild astrogliosis in all animals. In 21-day-old mice, TMT exposure significantly increased mRNA levels for ICAM-1 and MIP-1alpha in all genotypes. EB-22, GFAP, TNFalpha, and TGF-beta1 levels were significantly elevated in both wild-type and APOE knockout mice following TMT. At 8 months of age, genotype specific differences were observed. mRNA levels for GFAP, TNFbeta, TNFalpha, and MIP-1alpha were increased in both APOE knockout and APOE4 mice compared to wild-type mice. TMT exposure significantly increased mRNA levels for GFAP and MIP-1alpha in all animals. TNFalpha mRNA levels were increased in wild-type and APOE4 mice while EB22 mRNA levels were increased in both the APOE knockout and APOE4 mice but not wild-type mice. These data suggest an age-dependent effect on both microglia early inflammatory responses to injury associated with the APOE genotype. JF - Brain, behavior, and immunity AU - Harry, G J AU - Lefebvre d'Hellencourt, C AU - Bruccoleri, A AU - Schmechel, D AD - Neurotoxicology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 288 EP - 304 VL - 14 IS - 4 SN - 0889-1591, 0889-1591 KW - Apolipoprotein E4 KW - 0 KW - Apolipoproteins E KW - Chemokine CCL3 KW - Chemokine CCL4 KW - Cytokines KW - Glial Fibrillary Acidic Protein KW - Lymphotoxin-alpha KW - Macrophage Inflammatory Proteins KW - RNA, Messenger KW - Tgfb1 protein, mouse KW - Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Trimethyltin Compounds KW - Tumor Necrosis Factor-alpha KW - alpha 1-Antichymotrypsin KW - Intercellular Adhesion Molecule-1 KW - 126547-89-5 KW - trimethyltin KW - 1631-73-8 KW - Ribonucleases KW - EC 3.1.- KW - Index Medicus KW - Animals KW - Lymphotoxin-alpha -- genetics KW - Tumor Necrosis Factor-alpha -- immunology KW - Intercellular Adhesion Molecule-1 -- genetics KW - Tumor Necrosis Factor-alpha -- genetics KW - Cell Death -- immunology KW - Mice, Knockout KW - Gene Expression -- immunology KW - Macrophage Inflammatory Proteins -- immunology KW - Transforming Growth Factor beta -- genetics KW - Male KW - Macrophage Inflammatory Proteins -- genetics KW - RNA, Messenger -- analysis KW - Mice KW - Trimethyltin Compounds -- toxicity KW - Glial Fibrillary Acidic Protein -- genetics KW - Mice, Inbred DBA KW - Genotype KW - alpha 1-Antichymotrypsin -- genetics KW - Mice, Inbred C57BL KW - Lymphotoxin-alpha -- immunology KW - Female KW - Cytokines -- genetics KW - Nerve Degeneration -- immunology KW - Nerve Degeneration -- pathology KW - Cytokines -- immunology KW - Nerve Degeneration -- chemically induced KW - Hippocampus -- pathology KW - Hippocampus -- immunology KW - Aging -- immunology KW - Apolipoproteins E -- immunology KW - Apolipoproteins E -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72479827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain%2C+behavior%2C+and+immunity&rft.atitle=Age-dependent+cytokine+responses%3A+trimethyltin+hippocampal+injury+in+wild-type%2C+APOE+knockout%2C+and+APOE4+mice.&rft.au=Harry%2C+G+J%3BLefebvre+d%27Hellencourt%2C+C%3BBruccoleri%2C+A%3BSchmechel%2C+D&rft.aulast=Harry&rft.aufirst=G&rft.date=2000-12-01&rft.volume=14&rft.issue=4&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Brain%2C+behavior%2C+and+immunity&rft.issn=08891591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predisposition, susceptibility and DNA repair in radiation-induced skin cancer. AN - 72474954; 11187013 JF - Radiation research AU - Kraemer, K H AD - Basic Research Laboratory, National Cancer Institute, Rockville, Maryland, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 724;discussion 726 EP - 7 VL - 154 IS - 6 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Age of Onset KW - Sunlight -- adverse effects KW - Polymorphism, Genetic -- genetics KW - Humans KW - Xeroderma Pigmentosum -- genetics KW - Xeroderma Pigmentosum -- complications KW - Aging -- genetics KW - Skin Neoplasms -- genetics KW - DNA Repair -- genetics KW - Neoplasms, Radiation-Induced -- etiology KW - Genetic Predisposition to Disease -- genetics KW - Skin Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- metabolism KW - Neoplasms, Radiation-Induced -- genetics KW - Skin Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72474954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Predisposition%2C+susceptibility+and+DNA+repair+in+radiation-induced+skin+cancer.&rft.au=Kraemer%2C+K+H&rft.aulast=Kraemer&rft.aufirst=K&rft.date=2000-12-01&rft.volume=154&rft.issue=6&rft.spage=724%3Bdiscussion+726&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serologic examination of hepatitis B infection and immunization in HIV-positive youth and associated risks. The Pediatric AIDS Clinical Trials Group Protocol 220 Team. AN - 72473903; 11119432 AB - This seroprevalence report examines serologic evidence of hepatitis B immunization or infection and associated demographic/behavioral factors in adolescent (aged 12-20) subjects enrolled in a nontherapeutic clinical trial at 43 Pediatric AIDS Clinical Trials Group (PACTG) clinical centers. Subjects (n = 94) infected with the human immunodeficiency virus (HIV) through sexual activity were categorized as hepatitis B virus (HBV)-immunized, HBV-infected, or nonimmune by hepatitis B serology performed on specimens collected within the subject's first 48 weeks on study (1993-1995). Sixteen percent of the 94 serologically classified subjects were immunized; 19% HBV-infected; 65% nonimmune. Of the three risk factor scores examined (sociodemographic, sexual, and substance abuse), substance use alone demonstrated a significant difference among groups (despite virtually no reported injecting drug behavior), with the sexual risk score exhibiting marginally significant differences. Logistic regression analysis (restricted to nonimmunized subjects) showed that male-male sexual activity raised the odds of HBV infection by a factor of 5.14 (95% confidence interval [CI]: 1.45-18. 23) relative to heterosexual activity; and that for every one point increase on the substance abuse risk scale the odds of infection increased 5% (95% CI: 0.99-1.10). The HBV infection rate in PACTG 220 HIV-positive females is twice United States population-based rates; the rate in PACTG 220 HIV-positive males is nearly seven times higher. Past immunization efforts in this population appear to have been based on sexual activity volume without regard to injecting-drug use in sex partners. JF - AIDS patient care and STDs AU - Rogers, A S AU - Lindsey, J C AU - Futterman, D C AU - Zimmer, B AU - Abdalian, S E AU - D'Angelo, L J AD - Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892-7510, USA. ar44n@nih.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 651 EP - 657 VL - 14 IS - 12 SN - 1087-2914, 1087-2914 KW - Hepatitis B Antibodies KW - 0 KW - Hepatitis B Vaccines KW - AIDS/HIV KW - Humans KW - Seroepidemiologic Studies KW - Child KW - Predictive Value of Tests KW - Population Surveillance KW - Socioeconomic Factors KW - Logistic Models KW - Risk Factors KW - Adult KW - Substance Abuse, Intravenous -- complications KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Sexual Behavior -- statistics & numerical data KW - Hepatitis B Antibodies -- blood KW - Hepatitis B -- blood KW - Hepatitis B -- complications KW - Hepatitis B -- prevention & control KW - Hepatitis B -- immunology KW - Vaccination -- statistics & numerical data KW - HIV Seropositivity -- complications KW - Hepatitis B -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72473903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+patient+care+and+STDs&rft.atitle=Serologic+examination+of+hepatitis+B+infection+and+immunization+in+HIV-positive+youth+and+associated+risks.+The+Pediatric+AIDS+Clinical+Trials+Group+Protocol+220+Team.&rft.au=Rogers%2C+A+S%3BLindsey%2C+J+C%3BFutterman%2C+D+C%3BZimmer%2C+B%3BAbdalian%2C+S+E%3BD%27Angelo%2C+L+J&rft.aulast=Rogers&rft.aufirst=A&rft.date=2000-12-01&rft.volume=14&rft.issue=12&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=AIDS+patient+care+and+STDs&rft.issn=10872914&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2001-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protraction effects in radiation studies: epidemiology. AN - 72471843; 11187024 JF - Radiation research AU - Ron, E AD - Radiation Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 737 EP - 738 VL - 154 IS - 6 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Animals KW - Time KW - Radioactive Hazard Release KW - Dose Fractionation KW - Humans KW - Cohort Studies KW - Dose-Response Relationship, Radiation KW - Mutation KW - Linear Energy Transfer KW - Cells -- radiation effects KW - Risk Assessment KW - Cell Division -- radiation effects KW - Neoplasms, Radiation-Induced -- epidemiology KW - Radiation, Ionizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72471843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Protraction+effects+in+radiation+studies%3A+epidemiology.&rft.au=Ron%2C+E&rft.aulast=Ron&rft.aufirst=E&rft.date=2000-12-01&rft.volume=154&rft.issue=6&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adrenal cortical activation in murine colitis. AN - 72466912; 11113077 AB - Proper adrenal glucocorticoid secretion is crucial in the course of inflammatory diseases. However, the function and structure of the adrenal glands have not been examined in inflammatory bowel diseases. After induction of trinitrobenzene sulfonic acid (TNBS) colitis in SJL/J mice, plasma hormone and cytokine levels were measured, adrenal structure was analyzed by immunohistochemistry and electron microscopy, and adrenal cytokine/cytokine receptor expression were studied by RNase protection. Adrenals of colitic animals were enlarged and hypervascularized. These animals had a marked increase in plasma corticosterone levels during the course of colitis (270 +/- 34 vs. 16 +/- 11 ng/mL; P < 0.0001) but only a modest elevation of their concurrent adrenocorticotropin levels (57 +/- 13 vs. 29 +/- 9 pmol/L; NS). On electron microscopy, adrenocortical cells showed ultrastructural signs of marked stimulation, and intra-adrenal lymphocytes were frequently found in direct contact with these cells. Concurrent plasma levels of interleukin (IL)-6, the major cytokine activating the hypothalamic-pituitary-adrenal axis, were markedly increased (495 +/- 131 vs. 20 +/- 1.5 pg/mL; P < 0.0001), and this cytokine directly stimulated corticosterone secretion by adrenocortical cells in vitro. Intra-adrenal expression of IL-6 in animals with colitis was increased 80-fold, and the IL-6 receptor subunits IL-6R alpha and gp130 were present in the adrenal cells. Treatment of animals with neutralizing anti-IL-6 antibody reduced the TNBS-induced growth and activation of the adrenal cortices. Colitis is associated with a profound stimulation of adrenocortical cell function and glucocorticoid release. Direct immune-adrenal interactions seem to contribute to this activation of the adrenal glands during colitis. JF - Gastroenterology AU - Franchimont, D AU - Bouma, G AU - Galon, J AU - Wolkersdörfer, G W AU - Haidan, A AU - Chrousos, G P AU - Bornstein, S R AD - Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1560 EP - 1568 VL - 119 IS - 6 SN - 0016-5085, 0016-5085 KW - Antibodies, Monoclonal KW - 0 KW - Interleukin-6 KW - Trinitrobenzenesulfonic Acid KW - 8T3HQG2ZC4 KW - Corticosterone KW - W980KJ009P KW - Abridged Index Medicus KW - Index Medicus KW - Corticosterone -- secretion KW - Animals KW - Adrenal Glands -- metabolism KW - Disease Susceptibility KW - Interleukin-6 -- metabolism KW - Drug Resistance KW - Mice KW - Adrenal Glands -- drug effects KW - Antibodies, Monoclonal -- pharmacology KW - Adrenal Glands -- pathology KW - Mice, Inbred Strains KW - Interleukin-6 -- blood KW - Tumor Cells, Cultured KW - Mice, Inbred C57BL KW - Interleukin-6 -- immunology KW - Microscopy, Electron KW - Male KW - Adrenal Cortex -- secretion KW - Adrenal Cortex -- physiopathology KW - Colitis -- physiopathology KW - Colitis -- pathology KW - Colitis -- chemically induced KW - Colitis -- metabolism KW - Adrenal Cortex -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72466912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Adrenal+cortical+activation+in+murine+colitis.&rft.au=Franchimont%2C+D%3BBouma%2C+G%3BGalon%2C+J%3BWolkersd%C3%B6rfer%2C+G+W%3BHaidan%2C+A%3BChrousos%2C+G+P%3BBornstein%2C+S+R&rft.aulast=Franchimont&rft.aufirst=D&rft.date=2000-12-01&rft.volume=119&rft.issue=6&rft.spage=1560&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene. AN - 72458166; 11104789 AB - The V2 vasopressin receptor (V2R) plays a key role in the maintenance of a normal body water balance. To generate an in vivo model that allows the physiological and molecular analysis of the role of V2Rs in kidney function, we have created mouse lines that lack functional V2Rs by using targeted mutagenesis in mouse embryonic stem cells. Specifically, we introduced a nonsense mutation known to cause X-linked nephrogenic diabetes insipidus (XNDI) in humans (Glu242stop) into the mouse genome. V2R-deficient hemizygous male pups showed a decrease in basal urine osmolalities and were unable to concentrate their urine. These pups also exhibited an enlargement of renal pelvic space, failed to thrive, and died within the first week after birth due to hypernatremic dehydration. Interestingly, female mice heterozygous for the V2R mutation showed normal growth but displayed an XNDI-like phenotype, characterized by reduced urine concentrating ability of the kidney, polyuria, and polydipsia. Western blot analysis and immunoelectron microscopic studies showed that the loss of functional V2Rs had no significant effect on the basal expression levels of aquaporin-2 and the bumetanide-sensitive Na-K-2Cl cotransporter (BSC-1). The V2R mutant mice described here should serve as highly useful tools for the development of novel therapeutic strategies for the treatment of XNDI. JF - The Journal of clinical investigation AU - Yun, J AU - Schöneberg, T AU - Liu, J AU - Schulz, A AU - Ecelbarger, C A AU - Promeneur, D AU - Nielsen, S AU - Sheng, H AU - Grinberg, A AU - Deng, C AU - Wess, J AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1361 EP - 1371 VL - 106 IS - 11 SN - 0021-9738, 0021-9738 KW - Aqp2 protein, mouse KW - 0 KW - Aquaporin 2 KW - Aquaporin 6 KW - Aquaporins KW - Carrier Proteins KW - Codon, Nonsense KW - Receptors, Vasopressin KW - Sodium-Potassium-Chloride Symporters KW - Abridged Index Medicus KW - Index Medicus KW - Genetic Linkage KW - Animals KW - Carrier Proteins -- genetics KW - Aquaporins -- genetics KW - Gene Expression KW - Genetic Engineering -- methods KW - Kidney -- chemistry KW - Diabetes Insipidus -- mortality KW - Phenotype KW - Breeding KW - Aquaporins -- metabolism KW - Kidney -- ultrastructure KW - Microscopy, Immunoelectron KW - Male KW - Carrier Proteins -- metabolism KW - Kidney -- pathology KW - Diabetes Insipidus -- pathology KW - Diabetes Insipidus -- genetics KW - Mice KW - Genotype KW - Animals, Newborn KW - Mice, Inbred Strains KW - Mice, Mutant Strains KW - X Chromosome KW - Survival Rate KW - Female KW - Receptors, Vasopressin -- genetics KW - Receptors, Vasopressin -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72458166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Generation+and+phenotype+of+mice+harboring+a+nonsense+mutation+in+the+V2+vasopressin+receptor+gene.&rft.au=Yun%2C+J%3BSch%C3%B6neberg%2C+T%3BLiu%2C+J%3BSchulz%2C+A%3BEcelbarger%2C+C+A%3BPromeneur%2C+D%3BNielsen%2C+S%3BSheng%2C+H%3BGrinberg%2C+A%3BDeng%2C+C%3BWess%2C+J&rft.aulast=Yun&rft.aufirst=J&rft.date=2000-12-01&rft.volume=106&rft.issue=11&rft.spage=1361&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 2000 Apr;105(7):887-95 [10749568] Semin Nephrol. 1999 Jul;19(4):344-52 [10435672] Mol Cell Endocrinol. 1976 Mar;4(4):271-85 [177322] Anal Biochem. 1980 Sep 1;107(1):220-39 [6254391] Dev Psychobiol. 1986 May;19(3):211-22 [3709976] Endocrinology. 1988 Apr;122(4):1328-36 [2964362] J Androl. 1989 Sep-Oct;10(5):393-400 [2592268] J Pediatr. 1990 Sep;117(3):499-502 [2391611] Nature. 1992 May 28;357(6376):333-5 [1534149] Nature. 1992 May 28;357(6376):336-9 [1534150] Am J Hum Genet. 1992 Nov;51(5):1078-83 [1415251] Clin Nephrol. 1992 Oct;38(4):196-202 [1424306] Nature. 1993 Feb 11;361(6412):549-52 [8429910] N Engl J Med. 1993 May 27;328(21):1534-7 [8479490] Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8424-8 [8378314] Endocrinology. 1993 Oct;133(4):1849-59 [8404628] Methods Enzymol. 1993;225:890-900 [8231893] Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11663-7 [8265605] Nephron. 1993;65(3):346-9 [8289981] Hosp Pract (Off Ed). 1994 Mar 15;29(3):89-93, 97-8, 103-4 [8132731] Am J Hum Genet. 1994 Aug;55(2):266-77 [7913579] Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8984-8 [7522327] J Clin Endocrinol Metab. 1995 Apr;80(4):1184-6 [7714087] Annu Rev Med. 1995;46:331-43 [7541187] Hum Genet. 1995 Jul;96(1):70-8 [7607658] Nat Genet. 1995 Sep;11(1):33-9 [7550311] Cell. 1996 Mar 22;84(6):911-21 [8601314] EMBO J. 1996 Mar 15;15(6):1283-91 [8635461] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5860-5 [8650183] Kidney Int. 1996 Jun;49(6):1718-23 [8743484] J Clin Invest. 1996 Dec 15;98(12):2729-38 [8981918] Am J Physiol. 1997 Jan;272(1 Pt 2):F3-12 [9039043] J Clin Invest. 1997 Apr 15;99(8):1852-63 [9109429] J Clin Endocrinol Metab. 1997 Oct;82(10):3434-7 [9329382] J Am Soc Nephrol. 1997 Dec;8(12):1951-8 [9402099] Curr Opin Nephrol Hypertens. 1998 Jan;7(1):37-42 [9442361] J Biol Chem. 1998 Feb 20;273(8):4296-9 [9468475] J Mol Med (Berl). 1998 Apr;76(5):326-37 [9587067] J Am Soc Nephrol. 1998 Sep;9(9):1553-9 [9727361] Am J Physiol. 1998 Sep;275(3 Pt 2):F328-31 [9729503] Am J Physiol. 1998 Sep;275(3 Pt 2):F400-9 [9729513] Am J Physiol. 1998 Nov;275(5 Pt 2):F752-60 [9815132] Am J Med Sci. 1998 Nov;316(5):291-9 [9822111] Am J Med. 1998 Nov;105(5):431-42 [9831428] Am J Physiol. 1998 Dec;275(6 Pt 2):F885-93 [9843905] Am J Physiol. 1999 Jan;276(1 Pt 2):F96-F103 [9887085] Nat Genet. 1999 Jan;21(1):95-8 [9916798] Am J Physiol. 1999 Feb;276(2 Pt 2):F179-90 [9950948] Annu Rev Physiol. 1999;61:683-97 [10099706] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4386-91 [10737773] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sequence variation at two eosinophil-associated ribonuclease loci in humans. AN - 72453395; 11102386 AB - Host defense against invading pathogens is of great importance to the survival of higher organisms. We have been studying the evolution of mammalian eosinophil-associated ribonucleases (EARs), which are members of the ribonuclease A superfamily with known antipathogen activities. Earlier studies showed that positive selection promoted rapid diversification of paralogous EAR genes in both primates and rodents. Intraspecifically, however, it is unknown whether these genes also have divergent alleles. The recent discovery that the gene repertoire of the EAR family is much larger in rodents than in primates has led us to consider the possibility that primates maintain a large number of polymorphic alleles to compensate for a smaller gene repertoire. Here we present sequences of 2417 nucleotides at the two EAR loci, the eosinophil-derived neurotoxin (EDN, RNase 2) and eosinophil cationic protein (ECP, RNase 3), from >50 human individuals. Our data demonstrate that the nucleotide diversities (0.06-0.11%) at these loci are typical for human nuclear genes, thus permitting us to reject this polymorphism hypothesis. No significant departure from neutrality is noted and no signs of overdominant selection are observed. Similar patterns were observed in a preliminary study of chimpanzees. In summary, our results suggest that the antipathogen functions of the primate EARs are conserved after they are established and that these proteins are not currently undergoing rapid diversification in response to challenge from invading microorganisms. JF - Genetics AU - Zhang, J AU - Rosenberg, H F AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1949 EP - 1958 VL - 156 IS - 4 SN - 0016-6731, 0016-6731 KW - Blood Proteins KW - 0 KW - Eosinophil Granule Proteins KW - Proteins KW - Eosinophil-Derived Neurotoxin KW - EC 3.1.- KW - Ribonucleases KW - Eosinophil Cationic Protein KW - EC 3.1.27.- KW - RNASE3 protein, human KW - RNASE2 protein, human KW - EC 3.1.27.5 KW - Index Medicus KW - Infection -- genetics KW - Animals KW - Genetic Variation KW - Humans KW - Primates -- genetics KW - Amino Acid Sequence KW - Linkage Disequilibrium KW - European Continental Ancestry Group -- genetics KW - Infection -- enzymology KW - Alleles KW - Base Sequence KW - Haplotypes -- genetics KW - Models, Genetic KW - Molecular Sequence Data KW - Pan troglodytes -- genetics KW - Rodentia -- genetics KW - Species Specificity KW - Sequence Deletion KW - Genes KW - Multigene Family KW - Proteins -- genetics KW - Evolution, Molecular KW - Blood Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72453395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Sequence+variation+at+two+eosinophil-associated+ribonuclease+loci+in+humans.&rft.au=Zhang%2C+J%3BRosenberg%2C+H+F&rft.aulast=Zhang&rft.aufirst=J&rft.date=2000-12-01&rft.volume=156&rft.issue=4&rft.spage=1949&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-15 N1 - Date created - 2000-12-28 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AF294026; GENBANK; AF294027; AF294028; AF294022; AF294023; AF294024; AF294025; AF294020; AF294021; AF294019 N1 - SuppNotes - Cited By: J Mol Evol. 1999 Dec;49(6):721-8 [10594173] Nature. 1999 Aug 12;400(6745):667-71 [10458161] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4701-6 [10758160] Genetics. 1985 Sep;111(1):147-64 [4029609] Infect Immun. 1987 Apr;55(4):877-81 [3549562] Nature. 1988 Sep 8;335(6186):167-70 [3412472] J Immunol. 1989 Jun 15;142(12):4428-34 [2656865] Genetics. 1989 Nov;123(3):585-95 [2513255] Mol Biol Evol. 1990 Mar;7(2):111-22 [2108305] Genomics. 1990 Aug;7(4):535-46 [2387583] Genetics. 1991 Oct;129(2):513-23 [1743489] Genetics. 1993 Mar;133(3):693-709 [8454210] Mol Biol Evol. 1993 Sep;10(5):927-43 [8412653] Nature. 1995 Mar 9;374(6518):168-73 [7877689] Genomics. 1995 Mar 20;26(2):199-206 [7601443] Nat Genet. 1995 Jun;10(2):219-23 [7663519] J Biol Chem. 1995 Sep 15;270(37):21539-44 [7665566] J Biol Chem. 1996 May 24;271(21):12387-93 [8647842] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5 [8901588] J Biol Chem. 1997 Jan 17;272(3):1665-9 [8999843] Nucleic Acids Res. 1997 Nov 1;25(21):4235-9 [9336452] Blood. 1998 Mar 15;91(6):2126-32 [9490699] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3708-13 [9520431] J Infect Dis. 1998 Jun;177(6):1458-64 [9607820] Nucleic Acids Res. 1998 Jul 15;26(14):3358-63 [9649619] Nat Genet. 1998 Jul;19(3):233-40 [9662394] Curr Biol. 1998 Jul 30-Aug 13;8(16):943-6 [9707408] Lancet. 1998 Sep 12;352(9131):866-70 [9742978] Plant Cell. 1998 Nov;10(11):1833-46 [9811792] Nat Genet. 1999 May;22(1):59-62 [10319862] Nat Genet. 1999 Jul;22(3):231-8 [10391209] Nat Genet. 1999 Jul;22(3):239-47 [10391210] Immunol Res. 1999;20(3):261-74 [10741866] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Luteinizing hormone-releasing hormone (LHRH) biosynthesis and secretion in embryonic LHRH. AN - 72449599; 11108259 AB - Evidence indicates that LH-releasing hormone (LHRH) neurons can exhibit neuroendocrine secretory properties before entrance into the central nervous system. In this study, we evaluated LHRH biosynthesis and secretion in embryonic LHRH neurons maintained in nasal explants. Using ELISA and calcium imaging techniques, peptide content and single neuron activities were examined. LHRH neurons maintained for 7-10 days in vitro were found to possess a similar amount of LHRH/cell as the equivalent aged LHRH cells in vivo (postnatal day 1). LHRH peptide was measured in the medium of these relatively young cultures, and 40 mM KCl stimulated a 4-fold increase in LHRH secretion. KCl enhanced medium also resulted in a significant increase in LHRH content per culture (24.5 pg vs. 32.3). A similar effect was observed after muscimol-enhanced media (32.2 pg). Both agents also stimulated a substantial rise in intracellular calcium. Pretreatment of cultures with tetrodotoxin partially blocked the affects of muscimol on both peptide content and calcium activity, but not KCl. Calcium-depleted medium blocked the effects of KCl yet only attenuated the effects of muscimol. Treatment of cultures with cycloheximide blocked the effects of both muscimol and KCl. These results indicate that developing LHRH neurons are capable of synthesizing, secreting, and rapidly replenishing stores of LHRH peptide. JF - Endocrinology AU - Moore, J P AU - Wray, S AD - Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 4486 EP - 4495 VL - 141 IS - 12 SN - 0013-7227, 0013-7227 KW - GABA Agonists KW - 0 KW - Muscimol KW - 2763-96-4 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Tetrodotoxin KW - 4368-28-9 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Potassium Chloride KW - 660YQ98I10 KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Brain Chemistry KW - Calcium -- analysis KW - Potassium Chloride -- pharmacology KW - gamma-Aminobutyric Acid -- physiology KW - Mice KW - Pregnancy KW - Calcium -- metabolism KW - Culture Techniques KW - GABA Agonists -- pharmacology KW - Periodicity KW - Tetrodotoxin -- pharmacology KW - Muscimol -- pharmacology KW - Signal Transduction KW - Female KW - Gonadotropin-Releasing Hormone -- analysis KW - Neurons -- metabolism KW - Hypothalamus -- metabolism KW - Hypothalamus -- embryology KW - Gonadotropin-Releasing Hormone -- biosynthesis KW - Nose -- embryology KW - Nose -- metabolism KW - Gonadotropin-Releasing Hormone -- secretion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72449599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Luteinizing+hormone-releasing+hormone+%28LHRH%29+biosynthesis+and+secretion+in+embryonic+LHRH.&rft.au=Moore%2C+J+P%3BWray%2C+S&rft.aulast=Moore&rft.aufirst=J&rft.date=2000-12-01&rft.volume=141&rft.issue=12&rft.spage=4486&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Coexposure to ethanol with N-nitrosodimethylamine or 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone during lactation of rats: marked increase in O(6)-methylguanine-DNA adducts in maternal mammary gland and in suckling lung and kidney. AN - 72437744; 11097872 AB - Use of alcoholic beverages increases risk of cancer at several target sites, including the breast. Of several possible mechanisms for this effect, competitive inhibition by ethanol of hepatic clearance of nitrosamines, resulting in increased dose delivery to posthepatic tissues, gives the quantitatively most pronounced enhancement. We investigated whether this effect would pertain to the mammary gland, and to ethanol and nitrosamines delivered translactationally to sucklings. Ethanol (1.6 g/kg) was administered by gavage to nursing Sprague-Dawley rats 10 min before 5 mg/kg N-nitrosodimethylamine (NDMA) or 50 mg/kg 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK); treatment was on postnatal days 1, 7, or 14. Tissues taken 4 h later for analysis of O(6)-methylguanine in DNA were liver, blood, and mammary glands from the mothers, and liver, lung, kidney, and blood from the sucklings. Ethanol cotreatment resulted in a marked, 10-fold increase in O(6)-methylguanine adducts from NDMA in mammary gland, as well as smaller but significant increases in this tissue from NNK and in maternal blood cells from both chemicals; adducts in maternal liver decreased slightly. In the sucklings, ethanol cotreatment also lowered adducts in liver after NDMA or NNK treatment. After NDMA, adducts were also detected in suckling lung and kidney and were increased five- to 10-fold after ethanol coexposure. Adducts from either chemical, with or without ethanol, decreased markedly in all suckling tissues with development from postnatal day 1 to day 14. Thus ethanol coexposure with nitrosamines increases O(6)-methylguanine DNA adducts in mammary gland and strongly influences adduct formation in suckling tissues after translactational delivery. Copyright 2000 Academic Press. JF - Toxicology and applied pharmacology AU - Chhabra, S K AU - Anderson, L M AU - Perella, C AU - Desai, D AU - Amin, S AU - Kyrtopoulos, S A AU - Souliotis, V L AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, Frederick, Maryland 21702, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 191 EP - 200 VL - 169 IS - 2 SN - 0041-008X, 0041-008X KW - Carcinogens KW - 0 KW - DNA Adducts KW - Nitrosamines KW - Nitroso Compounds KW - 4-nitrosodimethylaniline KW - 138-89-6 KW - Ethanol KW - 3K9958V90M KW - Guanine KW - 5Z93L87A1R KW - 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone KW - 7S395EDO61 KW - O-(6)-methylguanine KW - 9B710FV2AE KW - Index Medicus KW - Rats KW - Animals, Suckling KW - Animals, Newborn KW - Animals KW - Rats, Sprague-Dawley KW - Female KW - Lactation -- physiology KW - Nitrosamines -- toxicity KW - Kidney -- metabolism KW - Carcinogens -- toxicity KW - Guanine -- pharmacokinetics KW - Lung -- metabolism KW - DNA Adducts -- metabolism KW - DNA Adducts -- blood KW - Mammary Glands, Animal -- metabolism KW - Guanine -- blood KW - Ethanol -- toxicity KW - Nitroso Compounds -- toxicity KW - Guanine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72437744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Coexposure+to+ethanol+with+N-nitrosodimethylamine+or+4-%28Methylnitrosamino%29-1-%283-pyridyl%29-1-butanone+during+lactation+of+rats%3A+marked+increase+in+O%286%29-methylguanine-DNA+adducts+in+maternal+mammary+gland+and+in+suckling+lung+and+kidney.&rft.au=Chhabra%2C+S+K%3BAnderson%2C+L+M%3BPerella%2C+C%3BDesai%2C+D%3BAmin%2C+S%3BKyrtopoulos%2C+S+A%3BSouliotis%2C+V+L&rft.aulast=Chhabra&rft.aufirst=S&rft.date=2000-12-01&rft.volume=169&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-08 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I and pharmacokinetic trial of weekly oral fluorouracil given with eniluracil and low-dose leucovorin to patients with solid tumors. AN - 72435985; 11099325 AB - Fluorouracil (5-FU) given as a weekly, high-dose 24-hour infusion is active and tolerable. We evaluated an oral regimen of eniluracil (which inactivates dihydropyrimidine dehydrogenase [DPD]), 5-FU, and leucovorin to simulate this schedule. Patients received a single 24-hour infusion of 5-FU (2,300 mg/m(2) on day 2) with leucovorin (15 mg orally [PO] bid on days 1 through 3) to provide reference pharmacokinetic data. Two weeks later, patients began treatment with eniluracil (20 mg) and leucovorin (15 mg) (PO bid on days 1 through 3) and 5-FU (10 to 15 mg/m(2) PO bid on day 2). Dose-limiting toxicity (diarrhea, neutropenia, and fatigue) was seen with 5-FU 15 mg/m(2) PO bid on day 2 given weekly for either 6 of 8 weeks or 3 of 4 weeks, whereas five of seven patients tolerated 5-FU 10 mg/m(2) PO bid given weekly for 3 of 4 weeks. Eniluracil led to a 35-fold reduction in 5-FU clearance. Fluoro-beta-alanine, a 5-FU catabolite, was not detected in plasma during oral 5-FU-eniluracil therapy. DPD activity was markedly suppressed in all patients during eniluracil therapy; the inactivation persisted after the last eniluracil dose; percentages of baseline values were 1.8% on day 5, 4.5% on day 12, and 23.6% on day 19. The recommended oral dosage of 5-FU (10 mg/m(2) PO bid) given with eniluracil and leucovorin is approximately 115-fold lower than the reference dosage for 24-hour infusional 5-FU. This difference is greater than expected given the reduction in 5-FU clearance. DPD inactivation persisted for several weeks after completion of eniluracil therapy. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Grem, J L AU - Harold, N AU - Shapiro, J AU - Bi, D Q AU - Quinn, M G AU - Zentko, S AU - Keith, B AU - Hamilton, J M AU - Monahan, B P AU - Donavan, S AU - Grollman, F AU - Morrison, G AU - Takimoto, C H AD - Medicine Branch, Division of Clinical Sciences, National Cancer Institute, National Naval Medical Center, Bethesda, MD 20889, USA. jgrem@helix.nih.gov Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 3952 EP - 3963 VL - 18 IS - 23 SN - 0732-183X, 0732-183X KW - Antimetabolites, Antineoplastic KW - 0 KW - Enzyme Inhibitors KW - eniluracil KW - 2E2W0W5XIU KW - Uracil KW - 56HH86ZVCT KW - Oxidoreductases KW - EC 1.- KW - Dihydrouracil Dehydrogenase (NADP) KW - EC 1.3.1.2 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Administration, Oral KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Leucovorin -- administration & dosage KW - Humans KW - Adult KW - Leucovorin -- adverse effects KW - Aged KW - Middle Aged KW - Oxidoreductases -- antagonists & inhibitors KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Enzyme Inhibitors -- adverse effects KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Neoplasms -- enzymology KW - Enzyme Inhibitors -- administration & dosage KW - Uracil -- analogs & derivatives KW - Antimetabolites, Antineoplastic -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacokinetics KW - Antimetabolites, Antineoplastic -- pharmacokinetics KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Uracil -- pharmacology KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- adverse effects KW - Uracil -- administration & dosage KW - Enzyme Inhibitors -- pharmacology KW - Fluorouracil -- pharmacokinetics KW - Uracil -- adverse effects KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72435985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+and+pharmacokinetic+trial+of+weekly+oral+fluorouracil+given+with+eniluracil+and+low-dose+leucovorin+to+patients+with+solid+tumors.&rft.au=Grem%2C+J+L%3BHarold%2C+N%3BShapiro%2C+J%3BBi%2C+D+Q%3BQuinn%2C+M+G%3BZentko%2C+S%3BKeith%2C+B%3BHamilton%2C+J+M%3BMonahan%2C+B+P%3BDonavan%2C+S%3BGrollman%2C+F%3BMorrison%2C+G%3BTakimoto%2C+C+H&rft.aulast=Grem&rft.aufirst=J&rft.date=2000-12-01&rft.volume=18&rft.issue=23&rft.spage=3952&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cisplatin and radiation sensitivity in human head and neck squamous carcinomas are independently modulated by glutathione and transcription factor NF-kappaB. AN - 72432745; 11084634 AB - Response to neoadjuvant cisplatin-based chemotherapy has been used to predict overall response to chemoradiation therapy and to select patients with head and neck squamous cell carcinoma (HNSCC) for organ preservation therapy in NCI and VA cooperative group trials. However, different molecular determinants have been reported to contribute to sensitivity of cells to cisplatin and radiation, including glutathione (GSH), and activation of nuclear factor-kappaB (NF-kappaB), a transcription factor that regulates cytoprotective genes. We have reported that NF-kappaB is constitutively activated in HNSCC, but the relationship of NF-kappaB to GSH and to cisplatin and radiation sensitivity in HNSCC is unknown. We examined human HNSCC lines to define the relationship of cisplatin and radiation sensitivity to intracellular GSH and NF-kappaB and determined whether HNSCC could be sensitized to these modalities by lowering the concentration of glutathione with L-buthionine sulfoximine or inhibiting activation of NF-kappaB by expression of a degradation-resistant mutant inhibitor-kappaBalpha. Cisplatin resistance did not predict radiation resistance in three HNSCC cell lines, UM-SCC-9, 11B, and, 38. Resistance to cisplatin correlated with intracellular GSH, and depletion of GSH by treatment with L-BSO sensitized UM-SCC-9 cells to cisplatin but not radiation. Conversely, radiation resistance was correlated with activation of NF-kappaB. Expression of a mutant Inhibitor-kappaB after gene transfer inhibited NF-kappaB and sensitized UM-SCC-9 cells to radiation but not cisplatin. GSH and transcription factor NF-alphaB can contribute independently to cisplatin and radiation sensitivity of human HNSCC. These results highlight the need to define molecular determinants of chemotherapy and radiation sensitivity for use in the selection of patients and as novel targets for therapy in future chemoradiation therapy trials for organ preservation in patients with HNSCC. JF - Head & neck AU - Kato, T AU - Duffey, D C AU - Ondrey, F G AU - Dong, G AU - Chen, Z AU - Cook, J A AU - Mitchell, J B AU - Van Waes, C AD - Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders National Institute of Health, Bldg. 10, Rm. 5D55, Bethesda, MD 20892, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 748 EP - 759 VL - 22 IS - 8 SN - 1043-3074, 1043-3074 KW - DNA, Complementary KW - 0 KW - DNA, Neoplasm KW - NF-kappa B KW - Glutathione KW - GAN16C9B8O KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Sensitivity and Specificity KW - Radiation Dosage KW - Reference Values KW - Tumor Cells, Cultured -- drug effects KW - Humans KW - Radiation Tolerance KW - DNA, Neoplasm -- analysis KW - Tumor Cells, Cultured -- radiation effects KW - DNA, Complementary -- analysis KW - Cell Survival KW - Polymerase Chain Reaction KW - Base Sequence KW - Drug Resistance, Neoplasm -- genetics KW - Cisplatin -- pharmacology KW - Molecular Sequence Data KW - Pharyngeal Neoplasms -- physiopathology KW - Pharyngeal Neoplasms -- radiotherapy KW - Glutathione -- metabolism KW - Carcinoma, Squamous Cell -- physiopathology KW - Pharyngeal Neoplasms -- drug therapy KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - NF-kappa B -- genetics KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72432745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Head+%26+neck&rft.atitle=Cisplatin+and+radiation+sensitivity+in+human+head+and+neck+squamous+carcinomas+are+independently+modulated+by+glutathione+and+transcription+factor+NF-kappaB.&rft.au=Kato%2C+T%3BDuffey%2C+D+C%3BOndrey%2C+F+G%3BDong%2C+G%3BChen%2C+Z%3BCook%2C+J+A%3BMitchell%2C+J+B%3BVan+Waes%2C+C&rft.aulast=Kato&rft.aufirst=T&rft.date=2000-12-01&rft.volume=22&rft.issue=8&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=Head+%26+neck&rft.issn=10433074&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-08 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The status of voltage-dependent calcium channels in alpha 1E knock-out mice. AN - 72431803; 11102459 AB - It has been hypothesized that R-type Ca currents result from the expression of the alpha(1E) gene. To test this hypothesis we examined the properties of voltage-dependent Ca channels in mice in which the alpha(1E) Ca channel subunit had been deleted. Application of omega-conotoxin GVIA, omega-agatoxin IVA, and nimodipine to cultured cerebellar granule neurons from wild-type mice inhibited components of the whole-cell Ba current, leaving a "residual" R current with an amplitude of approximately 30% of the total Ba current. A minor portion of this R current was inhibited by the alpha(1E)-selective toxin SNX-482, indicating that it resulted from the expression of alpha(1E). However, the majority of the R current was not inhibited by SNX-482. The SNX-482-sensitive portion of the granule cell R current was absent from alpha(1E) knock-out mice. We also identified a subpopulation of dorsal root ganglion (DRG) neurons from wild-type mice that expressed an SNX-482-sensitive component of the R current. However as with granule cells, most of the DRG R current was not blocked by SNX-482. We conclude that there exists a component of the R current that results from the expression of the alpha(1E) Ca channel subunit but that the majority of R currents must result from the expression of other Ca channel alpha subunits. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Wilson, S M AU - Toth, P T AU - Oh, S B AU - Gillard, S E AU - Volsen, S AU - Ren, D AU - Philipson, L H AU - Lee, E C AU - Fletcher, C F AU - Tessarollo, L AU - Copeland, N G AU - Jenkins, N A AU - Miller, R J AD - Mouse Cancer Genetics Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 8566 EP - 8571 VL - 20 IS - 23 KW - Calcium Channel Blockers KW - 0 KW - Calcium Channels, R-Type KW - Protein Subunits KW - SNX 482 KW - Spider Venoms KW - omega-Agatoxin IVA KW - Barium KW - 24GP945V5T KW - Nimodipine KW - 57WA9QZ5WH KW - omega-Conotoxin GVIA KW - 92078-76-7 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Ion Transport -- drug effects KW - Neurons -- drug effects KW - Cerebellum -- metabolism KW - Mice, Knockout KW - Calcium -- metabolism KW - Cerebellum -- cytology KW - Calcium Channel Blockers -- pharmacology KW - Ganglia, Spinal -- drug effects KW - Barium -- pharmacology KW - Neurons -- metabolism KW - Cell Survival -- genetics KW - omega-Agatoxin IVA -- pharmacology KW - Synaptic Transmission -- drug effects KW - Mice KW - Electrophysiology KW - Ganglia, Spinal -- cytology KW - Blotting, Western KW - Patch-Clamp Techniques KW - Cells, Cultured KW - Cerebellum -- drug effects KW - Ganglia, Spinal -- metabolism KW - Neurons -- cytology KW - Nimodipine -- pharmacology KW - Mice, Inbred C57BL KW - omega-Conotoxin GVIA -- pharmacology KW - Spider Venoms -- pharmacology KW - Calcium Channels, R-Type -- genetics KW - Calcium Channels, R-Type -- metabolism KW - Calcium Channels, R-Type -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72431803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=The+status+of+voltage-dependent+calcium+channels+in+alpha+1E+knock-out+mice.&rft.au=Wilson%2C+S+M%3BToth%2C+P+T%3BOh%2C+S+B%3BGillard%2C+S+E%3BVolsen%2C+S%3BRen%2C+D%3BPhilipson%2C+L+H%3BLee%2C+E+C%3BFletcher%2C+C+F%3BTessarollo%2C+L%3BCopeland%2C+N+G%3BJenkins%2C+N+A%3BMiller%2C+R+J&rft.aulast=Wilson&rft.aufirst=S&rft.date=2000-12-01&rft.volume=20&rft.issue=23&rft.spage=8566&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antineoplastic agents from natural sources: achievements and future directions. AN - 72431551; 11093353 AB - The influence of natural products upon anticancer drug discovery and design cannot be overestimated. Approximately 60% of all drugs now in clinical trials for the multiplicity of cancers are either natural products, compounds derived from natural products, contain pharmacophores derived from active natural products or are 'old drugs in new clothes', where (modified) natural products are attached to targeting systems. This review covers those materials that the authors are aware of as being in clinical trials through early 2000 and demonstrates how, even today, in the presence of massive numbers of agents from combinatorial libraries, the compounds produced by 'Mother Nature' are still in the forefront of cancer chemotherapeutics as sources of active chemotypes. JF - Expert opinion on investigational drugs AU - Cragg, G M AU - Newman, D J AD - Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick, Fairview Center, PO Box B, Frederick, MD 21702-1201, USA. cragg@dtpax2.ncifcrf.gov Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 2783 EP - 2797 VL - 9 IS - 12 SN - 1354-3784, 1354-3784 KW - Antineoplastic Agents KW - 0 KW - Antineoplastic Agents, Phytogenic KW - Marine Toxins KW - Index Medicus KW - Animals KW - Fungi -- chemistry KW - Humans KW - Bacteria -- chemistry KW - Marine Toxins -- pharmacology KW - Marine Toxins -- therapeutic use KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Antineoplastic Agents, Phytogenic -- pharmacology KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72431551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+investigational+drugs&rft.atitle=Antineoplastic+agents+from+natural+sources%3A+achievements+and+future+directions.&rft.au=Cragg%2C+G+M%3BNewman%2C+D+J&rft.aulast=Cragg&rft.aufirst=G&rft.date=2000-12-01&rft.volume=9&rft.issue=12&rft.spage=2783&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+investigational+drugs&rft.issn=13543784&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-08 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL. AN - 72430175; 11086085 AB - We examined the interplay between cytokines and adjuvants to optimize the induction of CTL by a mucosal HIV peptide vaccine. We show synergy between IL-12 and GM-CSF when administered together with the HIV peptide PCLUS3-18IIIB and cholera toxin (CT) in the induction of CTL activity and protection against mucosal viral transmission. Further, we examine the efficacy of mutant Escherichia coli labile toxin, LT(R192G), as a less toxic adjuvant than CT. LT(R192G) was as effective as or more effective than CT at inducing a mucosal CTL response. Moreover, LT(R192G) was as effective without IL-12 as CT was when combined with IL-12, and the response elicited by LT(R192G) with the vaccine was not further enhanced by the addition of IL-12. GM-CSF synergized with LT(R192G) without exogenous IL-12. Therefore, LT(R192G) may induce a more favorable cytokine response by not inhibiting IL-12 production. In particular, less IL-4 is made after LT(R192G) than CT immunization, and the response is less susceptible to anti-IL-12 inhibition. Thus, the choice of mucosal adjuvant affects the cytokine environment, and the mucosal response and protection can be enhanced by manipulating the cytokine environment with synergistic cytokine combinations incorporated in the vaccine. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Belyakov, I M AU - Ahlers, J D AU - Clements, J D AU - Strober, W AU - Berzofsky, J A AD - Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/12/01/ PY - 2000 DA - 2000 Dec 01 SP - 6454 EP - 6462 VL - 165 IS - 11 SN - 0022-1767, 0022-1767 KW - AIDS Vaccines KW - 0 KW - Adjuvants, Immunologic KW - Cytokines KW - Epitopes, T-Lymphocyte KW - Vaccines, Synthetic KW - Interleukin-12 KW - 187348-17-0 KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Abridged Index Medicus KW - Index Medicus KW - AIDS Vaccines -- administration & dosage KW - Peyer's Patches -- immunology KW - 3T3 Cells KW - Animals KW - Peyer's Patches -- cytology KW - Interleukin-12 -- administration & dosage KW - Spleen -- cytology KW - AIDS Vaccines -- immunology KW - Peyer's Patches -- virology KW - AIDS Vaccines -- chemical synthesis KW - Mice KW - Administration, Rectal KW - Amino Acid Sequence KW - Immunity, Innate KW - Mice, Inbred BALB C KW - Cytotoxicity, Immunologic -- immunology KW - Granulocyte-Macrophage Colony-Stimulating Factor -- administration & dosage KW - Lymphocyte Activation -- immunology KW - Vaccines, Synthetic -- immunology KW - Molecular Sequence Data KW - Vaccines, Synthetic -- administration & dosage KW - Spleen -- immunology KW - Spleen -- virology KW - Drug Synergism KW - Female KW - Cytokines -- administration & dosage KW - HIV-1 -- immunology KW - Adjuvants, Immunologic -- administration & dosage KW - Adjuvants, Immunologic -- physiology KW - Intestinal Mucosa -- immunology KW - Intestinal Mucosa -- virology KW - Intestinal Mucosa -- metabolism KW - Cytokines -- physiology KW - T-Lymphocytes, Cytotoxic -- immunology KW - Epitopes, T-Lymphocyte -- immunology KW - T-Lymphocytes, Cytotoxic -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72430175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Interplay+of+cytokines+and+adjuvants+in+the+regulation+of+mucosal+and+systemic+HIV-specific+CTL.&rft.au=Belyakov%2C+I+M%3BAhlers%2C+J+D%3BClements%2C+J+D%3BStrober%2C+W%3BBerzofsky%2C+J+A&rft.aulast=Belyakov&rft.aufirst=I&rft.date=2000-12-01&rft.volume=165&rft.issue=11&rft.spage=6454&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Opioid receptor imaging with positron emission tomography and [(18)F]cyclofoxy in long-term, methadone-treated former heroin addicts. AN - 72424147; 11082442 AB - Stabilized methadone-maintained former heroin addicts (MTPs) treated with effective doses of methadone have markedly reduced drug craving; reduction or elimination of heroin use; normalized stress-responsive hypothalamic-pituitary-adrenal, reproductive, and gastrointestinal function; and marked improvement in immune function and normal responses to pain, all of which are physiological indices modulated in part by endogenous and exogenous opioids directed at the mu and, in some cases, the kappa-opioid systems. This study was performed to explore opioid receptor binding in MTPs. Fourteen normal, healthy volunteers and 14 long-term MTPs in treatment for 2 to 27 years and receiving 30 to 90 mg/day of methadone were studied with positron emission tomography using tracer amounts of [(18)F]cyclofoxy, an opioid antagonist that labels mu and kappa opioid receptors. Imaging was performed in the morning, 22 h after the last dose of methadone in patients, and concurrent plasma levels of methadone were determined. Five brain regions of specific interest for addiction and pain research (thalamus, amygdala, caudate, anterior cingulate cortex, and putamen) were among the six regions of highest [(18)F]cyclofoxy binding. Specific binding of [(18)F]cyclofoxy was lower by 19 to 32% in these regions in MTPs compared with those in normal volunteers. The degree to which specific binding was lower in caudate and putamen correlated with methadone plasma levels (P <.01 and P <.05, respectively), suggesting that these lower levels of binding may be related to receptor occupancy with methadone and that significant numbers of opioid receptors may be available to function in their normal physiological roles. JF - The Journal of pharmacology and experimental therapeutics AU - Kling, M A AU - Carson, R E AU - Borg, L AU - Zametkin, A AU - Matochik, J A AU - Schluger, J AU - Herscovitch, P AU - Rice, K C AU - Ho, A AU - Eckelman, W C AU - Kreek, M J AD - National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1070 EP - 1076 VL - 295 IS - 3 SN - 0022-3565, 0022-3565 KW - Fluorine Radioisotopes KW - 0 KW - Receptors, Opioid, kappa KW - Receptors, Opioid, mu KW - Naltrexone KW - 5S6W795CQM KW - 6-deoxy-6-fluoronaltrexone KW - 669I3FR8VF KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Brain -- metabolism KW - Male KW - Female KW - Methadone -- therapeutic use KW - Heroin Dependence -- metabolism KW - Receptors, Opioid, mu -- analysis KW - Heroin Dependence -- drug therapy KW - Naltrexone -- analogs & derivatives KW - Tomography, Emission-Computed KW - Naltrexone -- metabolism KW - Methadone -- blood KW - Receptors, Opioid, kappa -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72424147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Opioid+receptor+imaging+with+positron+emission+tomography+and+%5B%2818%29F%5Dcyclofoxy+in+long-term%2C+methadone-treated+former+heroin+addicts.&rft.au=Kling%2C+M+A%3BCarson%2C+R+E%3BBorg%2C+L%3BZametkin%2C+A%3BMatochik%2C+J+A%3BSchluger%2C+J%3BHerscovitch%2C+P%3BRice%2C+K+C%3BHo%2C+A%3BEckelman%2C+W+C%3BKreek%2C+M+J&rft.aulast=Kling&rft.aufirst=M&rft.date=2000-12-01&rft.volume=295&rft.issue=3&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-20 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [URE3] prion propagation in Saccharomyces cerevisiae: requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydj1p. AN - 72415507; 11073991 AB - The [URE3] nonchromosomal genetic element is an infectious form (prion) of the Ure2 protein, apparently a self-propagating amyloidosis. We find that an insertion mutation or deletion of HSP104 results in inability to propagate the [URE3] prion. Our results indicate that Hsp104 is a common factor in the maintenance of two independent yeast prions. However, overproduction of Hsp104 does not affect the stability of [URE3], in contrast to what is found for the [PSI(+)] prion, which is known to be cured by either overproduction or deficiency of Hsp104. Like Hsp104, the Hsp40 class chaperone Ydj1p, with the Hsp70 class Ssa1p, can renature proteins. We find that overproduction of Ydj1p results in a gradual complete loss of [URE3]. The involvement of protein chaperones in the propagation of [URE3] indicates a role for protein conformation in inheritance. JF - Molecular and cellular biology AU - Moriyama, H AU - Edskes, H K AU - Wickner, R B AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0830, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 8916 EP - 8922 VL - 20 IS - 23 SN - 0270-7306, 0270-7306 KW - HSP40 Heat-Shock Proteins KW - 0 KW - HSP70 Heat-Shock Proteins KW - Heat-Shock Proteins KW - Molecular Chaperones KW - Prions KW - Saccharomyces cerevisiae Proteins KW - YDJ1 protein, S cerevisiae KW - 139874-78-5 KW - HsP104 protein, S cerevisiae KW - 143012-44-6 KW - Index Medicus KW - Genes, Fungal KW - Genetic Complementation Test KW - Models, Biological KW - Mutagenesis, Insertional KW - Gene Deletion KW - Heat-Shock Proteins -- metabolism KW - HSP70 Heat-Shock Proteins -- metabolism KW - HSP70 Heat-Shock Proteins -- genetics KW - Molecular Chaperones -- metabolism KW - Prions -- metabolism KW - Heat-Shock Proteins -- genetics KW - Saccharomyces cerevisiae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72415507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=%5BURE3%5D+prion+propagation+in+Saccharomyces+cerevisiae%3A+requirement+for+chaperone+Hsp104+and+curing+by+overexpressed+chaperone+Ydj1p.&rft.au=Moriyama%2C+H%3BEdskes%2C+H+K%3BWickner%2C+R+B&rft.aulast=Moriyama&rft.aufirst=H&rft.date=2000-12-01&rft.volume=20&rft.issue=23&rft.spage=8916&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-19 N1 - Date created - 2000-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1996 Aug;16(8):4378-86 [8754838] EMBO J. 1996 Jun 17;15(12):3127-34 [8670813] Genetics. 1996 Dec;144(4):1375-86 [8978027] Cell. 1997 May 30;89(5):811-9 [9182769] Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6618-22 [9192614] Science. 1997 Jul 18;277(5324):381-3 [9219697] Genetics. 1997 Oct;147(2):507-19 [9335589] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12503-8 [9356479] Chem Biol. 1995 Jan;2(1):1-5 [9383397] Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13932-7 [9391130] J Biol Chem. 1998 May 22;273(21):13203-7 [9582363] Cell. 1998 Jul 10;94(1):73-82 [9674429] J Biol Chem. 1998 Oct 23;273(43):27824-30 [9774392] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13363-83 [9811807] J Biol Chem. 1999 Jan 1;274(1):3-6 [9867802] J Biol Chem. 1999 Jan 8;274(2):555-8 [9872986] J Biol Chem. 1999 Jan 15;274(3):1181-4 [9880481] Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1498-503 [9990052] Science. 1999 Feb 26;283(5406):1339-43 [10037606] Genetics. 1999 Oct;153(2):585-94 [10511541] J Biol Chem. 1999 Nov 26;274(48):34396-402 [10567418] EMBO J. 2000 Feb 1;19(3):324-31 [10654931] EMBO J. 2000 May 2;19(9):1942-52 [10790361] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6625-9 [10823922] Genetics. 2000 Oct;156(2):559-70 [11014806] Nature. 1967 May 20;214(5090):764-6 [4963878] Nature. 1967 Sep 2;215(5105):1043-4 [4964084] Eur J Biochem. 1970 Jan;12(1):31-9 [5434281] J Bacteriol. 1971 May;106(2):519-22 [5573734] Biochem Biophys Res Commun. 1973 Jul 17;53(2):367-72 [4146147] Proc Natl Acad Sci U S A. 1976 Oct;73(10):3651-5 [790391] Science. 1982 Apr 9;216(4542):136-44 [6801762] Mol Gen Genet. 1984;197(2):345-6 [6394957] J Bacteriol. 1987 Jun;169(6):2598-600 [3294799] J Bacteriol. 1987 Aug;169(8):3521-4 [3301804] Gene. 1987;58(2-3):201-16 [2828185] Genetics. 1989 May;122(1):19-27 [2659436] Cell. 1990 Nov 16;63(4):673-86 [1977523] Mol Cell Biol. 1991 Feb;11(2):822-32 [1990286] Methods Enzymol. 1991;194:3-21 [2005794] J Cell Biol. 1991 Aug;114(4):609-21 [1869583] Mol Cell Biol. 1992 Jan;12(1):283-91 [1729605] Gene. 1992 Jan 2;110(1):119-22 [1544568] Genetics. 1993 May;134(1):81-150 [8514151] Science. 1994 Apr 22;264(5158):566-9 [7909170] Genes Dev. 1994 May 1;8(9):1087-105 [7926789] Nature. 1994 Dec 1;372(6505):475-8 [7984243] Science. 1995 May 12;268(5212):880-4 [7754373] Yeast. 1995 Apr 15;11(4):355-60 [7785336] EMBO J. 1995 Aug 15;14(16):4065-72 [7664746] Science. 1995 Oct 6;270(5233):93-5 [7569955] EMBO J. 1995 Sep 1;14(17):4365-73 [7556078] Science. 1996 Aug 2;273(5275):622-6 [8662547] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methamphetamine-induced neurotoxicity is attenuated in transgenic mice with a null mutation for interleukin-6. AN - 70777693; 11093760 AB - Increasing evidence implicates apoptosis as a major mechanism of cell death in methamphetamine (METH) neurotoxicity. The involvement of a neuroimmune component in apoptotic cell death after injury or chemical damage suggests that cytokines may play a role in METH effects. In the present study, we examined if the absence of IL-6 in knockout (IL-6-/-) mice could provide protection against METH-induced neurotoxicity. Administration of METH resulted in a significant reduction of [(125)I]RTI-121-labeled dopamine transporters in the caudate-putamen (CPu) and cortex as well as depletion of dopamine in the CPu and frontal cortex of wild-type mice. However, these METH-induced effects were significantly attenuated in IL-6-/- animals. METH also caused a decrease in serotonin levels in the CPu and hippocampus of wild-type mice, but no reduction was observed in IL-6-/- animals. Moreover, METH induced decreases in [(125)I]RTI-55-labeled serotonin transporters in the hippocampal CA3 region and in the substantia nigra-reticulata but increases in serotonin transporters in the CPu and cingulate cortex in wild-type animals, all of which were attenuated in IL-6-/- mice. Additionally, METH caused increased gliosis in the CPu and cortices of wild-type mice as measured by [(3)H]PK-11195 binding; this gliotic response was almost completely inhibited in IL-6-/- animals. There was also significant protection against METH-induced DNA fragmentation, measured by the number of terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeled (TUNEL) cells in the cortices. The protective effects against METH toxicity observed in the IL-6-/- mice were not caused by differences in temperature elevation or in METH accumulation in wild-type and mutant animals. Therefore, these observations support the proposition that IL-6 may play an important role in the neurotoxicity of METH. JF - Molecular pharmacology AU - Ladenheim, B AU - Krasnova, I N AU - Deng, X AU - Oyler, J M AU - Polettini, A AU - Moran, T H AU - Huestis, M A AU - Cadet, J L AD - Molecular Neuropsychiatry Section, National Institutes of Health/National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1247 EP - 1256 VL - 58 IS - 6 SN - 0026-895X, 0026-895X KW - Carrier Proteins KW - 0 KW - Dopamine Agents KW - Dopamine Plasma Membrane Transport Proteins KW - Interleukin-6 KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Serotonin Plasma Membrane Transport Proteins KW - Slc6a4 protein, mouse KW - Benzodiazepines KW - 12794-10-4 KW - Methamphetamine KW - 44RAL3456C KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Animals KW - Dopamine Agents -- toxicity KW - Drug Interactions KW - Carrier Proteins -- metabolism KW - Neurotoxicity Syndromes KW - Amphetamine -- toxicity KW - Temperature KW - Mice KW - Mice, Transgenic KW - Chromatography, High Pressure Liquid KW - Dopamine Agents -- pharmacokinetics KW - Mice, Knockout KW - Amphetamine -- pharmacokinetics KW - In Situ Nick-End Labeling KW - Mitochondria -- drug effects KW - Mice, Inbred C57BL KW - Mitochondria -- metabolism KW - Benzodiazepines -- pharmacology KW - Mutation KW - Membrane Glycoproteins -- metabolism KW - Methamphetamine -- pharmacokinetics KW - Interleukin-6 -- metabolism KW - Interleukin-6 -- genetics KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70777693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Methamphetamine-induced+neurotoxicity+is+attenuated+in+transgenic+mice+with+a+null+mutation+for+interleukin-6.&rft.au=Ladenheim%2C+B%3BKrasnova%2C+I+N%3BDeng%2C+X%3BOyler%2C+J+M%3BPolettini%2C+A%3BMoran%2C+T+H%3BHuestis%2C+M+A%3BCadet%2C+J+L&rft.aulast=Ladenheim&rft.aufirst=B&rft.date=2000-12-01&rft.volume=58&rft.issue=6&rft.spage=1247&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. AN - 70762930; 11093799 AB - Cocaine blocks the normal role of the dopamine transporter (DAT) in terminating dopamine signaling and in restricting its spatial spread through molecular interactions that remain largely obscure. Cocaine analog structure-activity studies suggest roles for cationic and hydrophobic interactions between DAT, dopamine, cocaine, and the sodium and chloride ions whose gradients power uptake processes. Tryptophan residues lying in putative DAT transmembrane domains could contribute to both aromatic and cationic interactions between DAT and dopamine or cocaine. We thus produced mutant DATs with alanine substitutions for tryptophans lying in or near putative DAT transmembrane domains. We have focused analyses on mutations that exert selective influences on affinities for dopamine or the cocaine analog CFT [(-)-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane]. Substitutions W162A, W255A, and W310A reduced dopamine uptake affinities. 5W266A, 12W555A, and 12W561A each reduced dopamine superficial recognition affinities by more than 3-fold and all retained affinity for CFT. W406A, W496A and W523A each reduced CFT affinity, and W84A increased CFT affinity. None of these four mutations decreased dopamine uptake affinity. These data, current provisional DAT structural models, and results from parallel studies of other mutants identify candidate dopamine-selective DAT domains for transmembrane dopamine permeation and regions in which mutations selectively lower CFT affinities. Tryptophan residues may contribute more extensively to these selective domains than other previously studied DAT amino acids. These sites provide tempting targets for selective blockers of cocaine recognition by DAT. JF - Molecular pharmacology AU - Lin, Z AU - Wang, W AU - Uhl, G R AD - Molecular Neurobiology Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA. Y1 - 2000/12// PY - 2000 DA - December 2000 SP - 1581 EP - 1592 VL - 58 IS - 6 SN - 0026-895X, 0026-895X KW - Carrier Proteins KW - 0 KW - Cations KW - Dopamine Plasma Membrane Transport Proteins KW - Dopamine Uptake Inhibitors KW - Ions KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Tritium KW - 10028-17-8 KW - (1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester KW - 50370-56-4 KW - Tryptophan KW - 8DUH1N11BX KW - Cocaine KW - I5Y540LHVR KW - Alanine KW - OF5P57N2ZX KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - COS Cells KW - Dose-Response Relationship, Drug KW - Amino Acid Sequence KW - Radioligand Assay KW - Tryptophan -- metabolism KW - Models, Biological KW - Cations -- metabolism KW - Mutagenesis, Site-Directed KW - Ions -- metabolism KW - Alanine -- metabolism KW - Signal Transduction -- drug effects KW - Binding, Competitive KW - Molecular Sequence Data KW - Alanine -- genetics KW - Mutation KW - Immunohistochemistry KW - Amino Acid Substitution KW - Tryptophan -- genetics KW - Protein Conformation KW - Cocaine -- analogs & derivatives KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- chemistry KW - Carrier Proteins -- drug effects KW - Carrier Proteins -- genetics KW - Dopamine -- metabolism KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70762930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Dopamine+transporter+tryptophan+mutants+highlight+candidate+dopamine-+and+cocaine-selective+domains.&rft.au=Lin%2C+Z%3BWang%2C+W%3BUhl%2C+G+R&rft.aulast=Lin&rft.aufirst=Z&rft.date=2000-12-01&rft.volume=58&rft.issue=6&rft.spage=1581&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Community outreach at biomedical research facilities. AN - 21250603; 11702244 AB - For biomedical researchers to fulfill their responsibility for protecting the environment, they must do more than meet the scientific challenge of reducing the number and volume of hazardous materials used in their laboratories and the engineering challenge of reducing pollution and shifting to cleaner energy sources. They must also meet the public relations challenge of informing and involving their neighbors in these efforts. The experience of the Office of Community Liaison of the National Institutes of Health (NIH) in meeting the latter challenge offers a model and several valuable lessons for other biomedical research facilities to follow. This paper is based on presentations by an expert panel during the Leadership Conference on Biomedical Research and the Environment held 1--2 November 1999 at NIH, Bethesda, Maryland. The risks perceived by community members are often quite different from those identified by officials at the biomedical research facility. The best antidote for misconceptions is more and better information. If community organizations are to be informed participants in the decision-making process, they need a simple but robust mechanism for identifying and evaluating the environmental hazards in their community. Local government can and should be an active and fully informed partner in planning and emergency preparedness. In some cases this can reduce the regulatory burden on the biomedical research facility. In other cases it might simplify and expedite the permitting process or help the facility disseminate reliable information to the community. When a particular risk, real or perceived, is of special concern to the community, community members should be involved in the design, implementation, and evaluation of targeted risk assessment activities. Only by doing so will the community have confidence in the results of those activities. NIH has involved community members in joint efforts to deal with topics as varied as recycling and soil testing. These ad hoc efforts are more likely to succeed if community members and groups have also been included in larger and longer term advisory committees. These committees institutionalize the outreach process. This can provide the facility with vocal and influential allies who create an independent line of communication with the larger community. JF - Environmental Health Perspectives AU - Goldman, M AU - Hedetniemi, J N AU - Herbert, E R AU - Sassaman, J S AU - Walker, B C AD - Office of Community Liason, National Institutes of Health, Bethesda, Maryland 20892-0002, USA., jh69z@nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 1009 EP - 1013 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 108 IS - Suppl 6 SN - 0091-6765, 0091-6765 KW - Risk Abstracts; Pollution Abstracts; Environment Abstracts KW - Risk assessment KW - Conferences KW - advisory committees KW - committees KW - Recycling KW - Energy sources KW - environmental hazards KW - Environmental protection KW - Waste management KW - Soil KW - Communications KW - Hazardous materials KW - Perception KW - Emergency preparedness KW - USA, Maryland KW - community organizations KW - responsibility KW - ENA 03:Energy KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21250603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Community+outreach+at+biomedical+research+facilities.&rft.au=Goldman%2C+M%3BHedetniemi%2C+J+N%3BHerbert%2C+E+R%3BSassaman%2C+J+S%3BWalker%2C+B+C&rft.aulast=Goldman&rft.aufirst=M&rft.date=2000-12-01&rft.volume=108&rft.issue=Suppl+6&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Conferences; advisory committees; committees; Recycling; environmental hazards; Energy sources; Environmental protection; Waste management; Soil; Communications; Hazardous materials; Perception; Emergency preparedness; community organizations; responsibility; USA, Maryland ER - TY - JOUR T1 - Design of Retroviral Vectors and Helper Cells for Gene Therapy AN - 18181089; 5209145 AB - During the past decade, gene therapy has been applied to the treatment of disease in hundreds of clinical trials. Various tools have been developed to deliver genes into human cells; among them, genetically engineered retroviruses are currently the most popular tool for gene delivery. Most of the systems contain vectors that are capable of accommodating genes of interest and helper cells that can provide the viral structural proteins and enzymes to allow for the generation of vector-containing infectious viral particles. Retroviridae is a family of retroviruses that differs in nucleotide and amino acid sequence, genome structure, pathogenicity, and host range. This diversity provides opportunities to use viruses with different biological characteristics to develop different therapeutic applications. Currently, a variety of retroviruses that provide distinct advantages for gene delivery has been modified and used in clinical trials. In this review, the genome structures of oncoviruses, lentiviruses, and spumaviruses are reviewed and examples of vectors derived from these viruses are described. As with any delivery tool, the efficiency, the ability to target certain tissue or cell type, the expression of the gene of interest, and the safety of retroviral-based systems are important for successful application of gene therapy. Significant efforts have been dedicated to these areas of research in recent years. Various modifications have been made to retroviral-based vectors and helper cells to alter gene expression, target delivery, improve viral titers, and increase safety. The principles and design of these modifications are discussed in this review. JF - Pharmacological Reviews AU - Hu, Wei-Shau AU - Pathak, V K AD - Bldg. 535, Rm. 336, HIV Drug Resistance Program, National Cancer Institute, FCRDC, Frederick, MD 21702, USA, whu@mail.ncifcrf.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 493 EP - 512 VL - 52 IS - 4 SN - 0031-6997, 0031-6997 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Expression vectors KW - Retrovirus KW - Gene therapy KW - Gene transfer KW - Reviews KW - Helper cells KW - W3 33181:Gene therapy vectors KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18181089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+Reviews&rft.atitle=Design+of+Retroviral+Vectors+and+Helper+Cells+for+Gene+Therapy&rft.au=Hu%2C+Wei-Shau%3BPathak%2C+V+K&rft.aulast=Hu&rft.aufirst=Wei-Shau&rft.date=2000-12-01&rft.volume=52&rft.issue=4&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Pharmacological+Reviews&rft.issn=00316997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Retrovirus; Gene therapy; Gene transfer; Expression vectors; Helper cells; Reviews ER - TY - JOUR T1 - Promoting Cessation of Tobacco Use AN - 18154592; 4876983 AB - Tobacco exacts an exorbitant toll on the nation's health, causing more than 450,000 deaths yearly. Although rates of smoking (the most common form of tobacco use) among adults have decreased in the past two decades, the decline has recently leveled off. Of additional concern is that youth tobacco use is increasing. A combination of recent scientific advances and social, legal, and public policy developments provides an unprecedented opportunity to reduce the burden of death and disease caused by tobacco use. Reducing tobacco use among adults and adolescents is an important public health goal. JF - Physician and Sportsmedicine AU - Morgan, G D AU - Fox, B J AD - Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Blvd, Rm 4034 MSC 7337, Rockville, USA, gmorgan@nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 59 EP - 64 VL - 28 IS - 12 SN - 0091-3847, 0091-3847 KW - Physical Education Index KW - Smoking cessation KW - Tobacco KW - Sports medicine KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18154592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physician+and+Sportsmedicine&rft.atitle=Promoting+Cessation+of+Tobacco+Use&rft.au=Morgan%2C+G+D%3BFox%2C+B+J&rft.aulast=Morgan&rft.aufirst=G&rft.date=2000-12-01&rft.volume=28&rft.issue=12&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Physician+and+Sportsmedicine&rft.issn=00913847&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Sports medicine; Tobacco; Smoking cessation ER - TY - JOUR T1 - Immortalization of mammary cells from estrogen receptor alpha knock-out and wild-type mice AN - 18025567; 4862550 AB - The development and morphogenesis of the mammary gland, a major estrogen target tissue, is regulated cooperatively by the ovarian steroid hormones 17 beta -estradiol and progesterone. The estrogen receptor (ER) alpha knock-out ( alpha ERKO) mouse is an informative model to study ER-dependent development and ER signaling pathways in vivo. However, compatible in vitro models are not yet established. Crucial insights into cellular signaling and tissue interaction were achieved by the study of primary cultures of mammary cells and whole-organ culture. However, these models have their limitations due to their short lifespan and, as such, do not represent stable in vitro models. Here, we report the establishment of five immortalized cell lines derived from the mammary gland of 12-wk-old alpha ERKO and wild-type mice (C57BL/6). The use of a nitex filter and a Percoll gradient allowed the separation of different cell pools derived from the mammary gland of either alpha ERKO or wild-type mice. Primary cultures were established according to previously described procedures. Immortalization was accomplished by retroviral infection of primary cultures with the catalytic unit of the human telomerase gene, the telomerase reverse transcriptase (hTERT). hTERT expression is reported to be critical for cell immortalization by preventing telomere shortening. JF - In Vitro Cellular & Developmental Biology - Animal AU - Mueller, SO AU - Barrett, J C AU - Tahara, Hidetoshi AU - Korach, K S AD - Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA, korach@niehs.nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 620 EP - 624 PB - [URL:http://journals.allenpress.com/jrnlserv/?request=get-abstract &issn=1071-2690&volume=36&page=620] VL - 36 IS - 10 SN - 1071-2690, 1071-2690 KW - knockout mice KW - C57BL/6 mice KW - estrogen receptors KW - steroid hormones KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Telomeres KW - Mammary gland KW - Organ culture KW - Immortalization KW - W 30965:Miscellaneous, Reviews KW - W3 33220:Cell culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18025567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.atitle=Immortalization+of+mammary+cells+from+estrogen+receptor+alpha+knock-out+and+wild-type+mice&rft.au=Mueller%2C+SO%3BBarrett%2C+J+C%3BTahara%2C+Hidetoshi%3BKorach%2C+K+S&rft.aulast=Mueller&rft.aufirst=SO&rft.date=2000-12-01&rft.volume=36&rft.issue=10&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=In+Vitro+Cellular+%26+Developmental+Biology+-+Animal&rft.issn=10712690&rft_id=info:doi/10.1290%2F1071-2690%282000%29036%280620%3AIOMCFE%292.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mammary gland; Immortalization; Organ culture; Telomeres DO - http://dx.doi.org/10.1290/1071-2690(2000)036(0620:IOMCFE)2.0.CO;2 ER - TY - JOUR T1 - The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins AN - 18013429; 4863575 AB - Monoamine compartmentalization in monoaminergic neurons uses serial action of the plasma membrane and vesicular monoamine (VAMT2) transporters. We can now define the sequences of the genes encoding these transporters in mice and humans, examine influences of deletions of this gene and alteration in its expression levels in transgenic mice, and identify sequence polymorphisms in the human VMAT2 gene. Examination of VMAT2 variants can provide potential insights into roles for allelic variants at these loci in variant drug responses and in diseases linked to monoaminergic systems, including substance abuse and Parkinson's disease. JF - FASEB Journal AU - Uhl, G R AU - Li, Su AU - Takahashi, Nobuyuki AU - Itokawa, Kaori AU - Lin, Zhicheng AU - Hazama, Masatoshi AU - Sora, Ichiro AD - Molecular Neurobiology, Rm. 302, 5500 Nathan Shock Dr., Baltimore, MD 21224, USA, guhl@intra.nida.nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 2459 EP - 2465 VL - 14 IS - 15 SN - 0892-6638, 0892-6638 KW - VMAT2 gene KW - transgenic mice KW - man KW - vesicular monoamine transporters KW - monoamines KW - vesicular monoamine transporter KW - CSA Neurosciences Abstracts; Toxicology Abstracts; Genetics Abstracts KW - Heart KW - Parkinson's disease KW - Aging KW - Drug abuse KW - Toxins KW - Plasma membranes KW - Reviews KW - Neurons KW - Locomotor activity KW - Amphetamine KW - G 07397:Rodentia (mice) KW - N3 11115:Neurogenetics KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18013429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+Journal&rft.atitle=The+VMAT2+gene+in+mice+and+humans%3A+amphetamine+responses%2C+locomotion%2C+cardiac+arrhythmias%2C+aging%2C+and+vulnerability+to+dopaminergic+toxins&rft.au=Uhl%2C+G+R%3BLi%2C+Su%3BTakahashi%2C+Nobuyuki%3BItokawa%2C+Kaori%3BLin%2C+Zhicheng%3BHazama%2C+Masatoshi%3BSora%2C+Ichiro&rft.aulast=Uhl&rft.aufirst=G&rft.date=2000-12-01&rft.volume=14&rft.issue=15&rft.spage=2459&rft.isbn=&rft.btitle=&rft.title=FASEB+Journal&rft.issn=08926638&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Toxins; Aging; Locomotor activity; Heart; Amphetamine; Neurons; Drug abuse; Parkinson's disease; Plasma membranes; Reviews ER - TY - JOUR T1 - Attenuated Allergic Responses to House Dust Mite Antigen in Feed-Restricted Rats AN - 17863329; 5113355 AB - Caloric restriction has been shown to alter a broad range of immunological end points in both experimental animals and humans. The objective of this study was to investigate the effect of short-term moderate feed restriction (25% reduction) on allergic immune responses in Brown Norway rats. After 3 weeks of acclimation to their feed regimens, rats were sensitized and 2 weeks later challenged with house dust mite (HDM) antigen via intratracheal instillation. Feed restriction resulted in lower levels of antigen-specific IgE in serum and reduced antigenspecific lympho-proliferative activity in pulmonary lymph nodes. Feed restriction also attenuated pulmonary inflammation, as evidenced by lower levels of lactate dehydrogenase and total protein, decreased infiltration of neutrophils and eosinophils, and reduced secretion of pro-inflammatory cytokine tumor necrosis factor (TNF)- alpha in bronchoalveolar lavage fluid. In addition, feed restriction decreased TNF- alpha secretion in serum and decreased mRNA expression of TNF- alpha and interleukin-6 in pulmonary lymph nodes. We conclude that feed restriction strongly dampened the allergic immune responses to HDM in rats and that this attenuation was associated with decreased expression and secretion of pro-inflammatory cytokines. JF - Environmental Health Perspectives AU - Dong, W AU - Kari, F W AU - Selgrade, MJK AU - Gilmour, MI AD - National Institute of Environmental Health Sciences, MD F1-05, P.O. Box 12233, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709 USA, kari@niehs.nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 1125 EP - 1131 VL - 108 IS - 12 SN - 0091-6765, 0091-6765 KW - rats KW - Acari KW - dust mites KW - chiggers KW - ticks KW - Entomology Abstracts; Toxicology Abstracts KW - Interleukin 6 KW - Diets KW - Allergenicity KW - Hypersensitivity KW - Antigens KW - House dust KW - Allergens KW - Tumor necrosis factor-^a KW - Cytokines KW - Immune response KW - Z 05206:Medical & veterinary entomology KW - X 24173:Animals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17863329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Attenuated+Allergic+Responses+to+House+Dust+Mite+Antigen+in+Feed-Restricted+Rats&rft.au=Dong%2C+W%3BKari%2C+F+W%3BSelgrade%2C+MJK%3BGilmour%2C+MI&rft.aulast=Dong&rft.aufirst=W&rft.date=2000-12-01&rft.volume=108&rft.issue=12&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Acari; Hypersensitivity; House dust; Antigens; Allergens; Allergenicity; Diets; Immune response; Cytokines; Tumor necrosis factor-^a; Interleukin 6 ER - TY - JOUR T1 - Identification and Characterization of the scl Gene Encoding a Group A Streptococcus Extracellular Protein Virulence Factor with Similarity to Human Collagen AN - 17857311; 4869420 AB - Group A Streptococcus (GAS) expresses cell surface proteins that mediate important biological functions such as resistance to phagocytosis, adherence to plasma and extracellular matrix proteins, and degradation of host proteins. An open reading frame encoding a protein of 348 amino acid residues was identified by analysis of the genome sequence available for a serotype M1 strain. The protein has an LPATGE sequence located near the carboxy terminus that matches the consensus sequence (LPXTGX) present in many gram-positive cell wall-anchored molecules. Importantly, the central region of this protein contains 50 contiguous Gly-X-X triplet amino acid motifs characteristic of the structure of human collagen. The structural gene (designated scl for streptococcal collagen-like) was present in all 50 GAS isolates tested, which together express 21 different M protein types and represent the breadth of genomic diversity in the species. DNA sequence analysis of the gene in these 50 isolates found that the number of contiguous Gly-X-X motifs ranged from 14 in serotype M6 isolates to 62 in a serotype M41 organism. M1 and M18 organisms had the identical allele, which indicates very recent horizontal gene transfer. The gene was transcribed abundantly in the logarithmic but not stationary phase of growth, a result consistent with the occurrence of a DNA sequence with substantial homology with a consensus Mga binding site immediately upstream of the scl open reading frame. Two isogenic mutant M1 strains created by nonpolar mutagenesis of the scl structural gene were not attenuated for mouse virulence as assessed by intraperitoneal inoculation. In contrast, the isogenic mutant derivative made from the M1 strain representative of the subclone most frequently causing human infections was significantly less virulent when inoculated subcutaneously into mice. In addition, both isogenic mutant strains had significantly reduced adherence to human A549 epithelial cells grown in culture. These studies identify a new extracellular GAS virulence factor that is widely distributed in the species and participates in adherence to host cells and soft tissue pathology. JF - Infection and Immunity AU - Lukomski, S AU - Nakashima, K AU - Abdi, I AU - Cipriano, V J AU - Ireland, R M AU - Reid, S D AU - Adams, G G AU - Musser, J M AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th St., Hamilton, MT 59840, jmusser@niaid.nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 6542 EP - 6553 VL - 68 IS - 12 SN - 0019-9567, 0019-9567 KW - mice KW - streptococci KW - scl gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Nucleotide sequence KW - Mutagenesis KW - Collagen KW - Cell adhesion KW - Virulence KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17857311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+and+Characterization+of+the+scl+Gene+Encoding+a+Group+A+Streptococcus+Extracellular+Protein+Virulence+Factor+with+Similarity+to+Human+Collagen&rft.au=Lukomski%2C+S%3BNakashima%2C+K%3BAbdi%2C+I%3BCipriano%2C+V+J%3BIreland%2C+R+M%3BReid%2C+S+D%3BAdams%2C+G+G%3BMusser%2C+J+M&rft.aulast=Lukomski&rft.aufirst=S&rft.date=2000-12-01&rft.volume=68&rft.issue=12&rft.spage=6542&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus; Nucleotide sequence; Cell adhesion; Collagen; Virulence; Mutagenesis ER - TY - JOUR T1 - Identification of 11 pH-Regulated Genes in Borrelia burgdorferi Localizing to Linear Plasmids AN - 17839004; 4869400 AB - When Borrelia burgdorferi is transmitted from the tick vector to the mammalian host, the bacterium experiences alterations in its environment, such as changes in temperature and pH. Previously, we observed numerous alterations in the membrane protein profile when B. burgdorferi B31 was grown at pH 7.0 compared to pH 8.0Here we identify 11 genes localizing to linear plasmids that are up- regulated at pH 7.0 relative to pH 8.0 in vitro. Seven genes (bba03, bba24, bba64, bba66, bbe31, bbj41/bbi39 [encoding products that are 99% identical], and bbk01) were indirectly identified by proteomic analysis of membrane proteins. Another gene, bba36, was identified by screening a B. burgdorferi B31 genomic library with cross-adsorbed hyperimmune rabbit serum. Two additional genes, bba65 and bba73, were identified by Northern blot analysis. Genes bba64, bba65, bba66, bbj41/bbi39, and bba73 are members of paralogous gene family 54, and bbe31 is a member of the closely related paralogous gene family 60. Gene bba24 is part of a bicistronic operon with bba25 that encodes the well-characterized decorin binding proteins A and B. All 11 genes were transcriptionally regulated, yet the degree of pH regulation varied, with some genes more tightly regulated than others. The regions upstream of these pH-regulated genes appeared to be unrelated, yet many contained dyad repeats ranging from 12 to 25 nucleotides in length that may be involved in the regulation of these genes. JF - Infection and Immunity AU - Carroll, JA AU - Cordova, R M AU - Garon, C F AD - 903 South 4th St., Hamilton, MT 59840, jcarroll@niaid.nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 6677 EP - 6684 VL - 68 IS - 12 SN - 0019-9567, 0019-9567 KW - bba gene KW - bbe gene KW - bbj gene KW - bbk gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Borrelia burgdorferi KW - Vectors KW - Plasmids KW - Gene families KW - Gene regulation KW - pH effects KW - Lyme disease KW - J 02855:Human Bacteriology: Others KW - G 07203:Plasmids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17839004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+of+11+pH-Regulated+Genes+in+Borrelia+burgdorferi+Localizing+to+Linear+Plasmids&rft.au=Carroll%2C+JA%3BCordova%2C+R+M%3BGaron%2C+C+F&rft.aulast=Carroll&rft.aufirst=JA&rft.date=2000-12-01&rft.volume=68&rft.issue=12&rft.spage=6677&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Borrelia burgdorferi; pH effects; Gene families; Gene regulation; Lyme disease; Vectors; Plasmids ER - TY - JOUR T1 - Identification and Immunogenicity of Group A Streptococcus Culture Supernatant Proteins AN - 17837006; 4869405 AB - Extracellular proteins made by group A Streptococcus (GAS) play critical roles in the pathogenesis of human infections caused by this bacterium. Although many extracellular GAS proteins have been identified and characterized, there has been no systematic analysis of culture supernatant proteins. Proteins present in the culture supernatant of strains of serotype M1 (MGAS 5005) and M3 (MGAS 315) mutants lacking production of the major extracellular cysteine protease were separated by two-dimensional gel electrophoresis and identified by amino-terminal amino acid sequencing and interrogation of available databases, including a serotype M1 genome sequence. In the aggregate, amino-terminal amino acid sequence data for 66 protein spots were generated, 53 unique sequences were obtained, and 44 distinct proteins were identified. Sixteen of the 44 proteins had apparent secretion signal sequences and 27 proteins did not. Eight of the 16 proteins with apparent secretion signal sequences have not been previously described for GAS. Antibodies against most of the apparently secreted proteins were present in sera from mice infected subcutaneously with MGAS 5005 or MGAS 315Humans with documented GAS infections (pharyngitis, acute rheumatic fever, and severe invasive disease) also had serum antibodies reacting with many of the apparently secreted proteins, indicating that they were synthesized in the course of GAS-human interaction. The genes encoding four of the eight previously undescribed and apparently secreted culture supernatant proteins were cloned, and the proteins were overexpressed in Escherichia coli. Western blot analysis with these recombinant proteins and sera from GAS-infected mice and humans confirmed the immunogenicity of these proteins. Taken together, the data provide new information about the molecular aspects of GAS-host interactions. JF - Infection and Immunity AU - Lei, B AU - Mackie, S AU - Lukomski, S AU - Musser, J M AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th St., Hamilton, MT 59840, jmusser@niaid.nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 6807 EP - 6818 VL - 68 IS - 12 SN - 0019-9567, 0019-9567 KW - culture supernatant KW - overexpression KW - amino acid sequence KW - extracellular proteins KW - Microbiology Abstracts B: Bacteriology KW - Antibodies KW - Antigens KW - Immunogenicity KW - Escherichia coli KW - Streptococcus pyogenes KW - J 02833:Immune response and immune mechanisms KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17837006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+and+Immunogenicity+of+Group+A+Streptococcus+Culture+Supernatant+Proteins&rft.au=Lei%2C+B%3BMackie%2C+S%3BLukomski%2C+S%3BMusser%2C+J+M&rft.aulast=Lei&rft.aufirst=B&rft.date=2000-12-01&rft.volume=68&rft.issue=12&rft.spage=6807&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Streptococcus pyogenes; Antibodies; Immunogenicity; Antigens ER - TY - JOUR T1 - Visualization of Substrate Binding and Translocation by the ATP-Dependent Protease, ClpXP AN - 17772504; 4826177 AB - Binding and internalization of a protein substrate by E. coli ClpXP was investigated by electron microscopy. In sideviews of ATP gamma S-stabilized ClpXP complexes, a narrow axial channel was visible in ClpX, surrounded by protrusions on its distal surface. When substrate lambda O protein was added, extra density attached to this surface. Upon addition of ATP, this density disappeared as lambda O was degraded. When ATP was added to proteolytically inactive ClpXP- lambda O complexes, the extra density transferred to the center of ClpP and remained inside ClpP after separation from ClpX. We propose that substrates of ATP-dependent proteases bind to specific sites on the distal surface of the ATPase, and are subsequently unfolded and translocated into the internal chamber of the protease. JF - Molecular Cell AU - Ortega, J AU - Singh, S K AU - Ishikawa, T AU - Maurizi, M R AU - Steven, A C AD - Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases and National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA, alasdair_steven@nih.gov Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 1515 EP - 1521 VL - 6 IS - 6 SN - 1097-2765, 1097-2765 KW - substrate binding KW - ClpXP protein KW - Microbiology Abstracts B: Bacteriology KW - Escherichia coli KW - Proteinase KW - Electron microscopy KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17772504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cell&rft.atitle=Visualization+of+Substrate+Binding+and+Translocation+by+the+ATP-Dependent+Protease%2C+ClpXP&rft.au=Ortega%2C+J%3BSingh%2C+S+K%3BIshikawa%2C+T%3BMaurizi%2C+M+R%3BSteven%2C+A+C&rft.aulast=Ortega&rft.aufirst=J&rft.date=2000-12-01&rft.volume=6&rft.issue=6&rft.spage=1515&rft.isbn=&rft.btitle=&rft.title=Molecular+Cell&rft.issn=10972765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; Proteinase; Electron microscopy ER - TY - JOUR T1 - Targeting the Human mdr1 Gene by super(125)I-Labeled Triplex-Forming Oligonucleotides AN - 17768519; 4827424 AB - Antigene radiotherapy is our approach to targeting specific sites in the genome by combining the highly localized DNA damage produced by the decay of Auger electron emitters, such as super(125)I, with the sequence-specific action of triplex-forming oligonucleotides (TFO). As a model, we used the multidrug resistance gene (mdr1) overexpressed and amplified nearly 100 times in the human KB-V1 carcinoma cell line. Phosphodiester pyrrazolopyrimidine dG (PPG)-modified TFO complementary to the polypurine-polypyrimidine region of the mdr1 gene were synthesized and labeled with super(125)I-dCTP at the C5 position of two cytosines by the primer extension method. super(125)I-TFO were delivered into KB-V1 cells with several delivery systems. DNA from the super(125)I-TFO-treated cells was recovered and analyzed for sequence-specific cleavage in the mdr1 target by Southern hybridization. Experiments with plasmid DNA containing the mdr1 polypurine-polypyrimidine region and with purified genomic DNA confirmed the ability of the designed super(125)I-TFO to bind to and introduce double-strand breaks into the target sequence. We showed that super(125)I-TFO in nanomolar concentrations can recognize and cleave a target sequence in the mdr1 gene in situ, that is, within isolated nuclei and intact digitonin-permeabilized cells. Our results demonstrate the ability of super(125)I-TFO to target specific sequences in their natural environment, that is, within the eukaryotic nucleus. The nearly 100-fold amplification of the mdr1 gene in KB-V1 cells affords a very useful cell culture model for evaluation of methods to produce sequence-specific DNA double-strand breaks for gene-specific radiotherapy. JF - Antisense and Nucleic Acid Drug Development AU - Sedelnikova, O A AU - Panyutin, I G AU - Luu, AN AU - Reed, M W AU - Licht, T AU - Gottesman, M M AU - Neumann, R D AD - NMD, CC, National Institutes of Health, Building 10, Room IC401, 10 Center Drive MSC 1180, Bethesda, MD 20892-1180, USA Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 443 EP - 452 VL - 10 IS - 6 SN - 1087-2906, 1087-2906 KW - man KW - cancer KW - mdr1 gene KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Antisense KW - Radiotherapy KW - Multidrug resistance KW - Oligonucleotides KW - N 14560:Antisense research KW - W 30965:Miscellaneous, Reviews KW - W3 33380:Antisense UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17768519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antisense+and+Nucleic+Acid+Drug+Development&rft.atitle=Targeting+the+Human+mdr1+Gene+by+super%28125%29I-Labeled+Triplex-Forming+Oligonucleotides&rft.au=Sedelnikova%2C+O+A%3BPanyutin%2C+I+G%3BLuu%2C+AN%3BReed%2C+M+W%3BLicht%2C+T%3BGottesman%2C+M+M%3BNeumann%2C+R+D&rft.aulast=Sedelnikova&rft.aufirst=O&rft.date=2000-12-01&rft.volume=10&rft.issue=6&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Antisense+and+Nucleic+Acid+Drug+Development&rft.issn=10872906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Antisense; Oligonucleotides; Multidrug resistance; Radiotherapy ER - TY - JOUR T1 - Oligonucleotide Sequence-Specific Inhibition of Gene Expression, Tumor Growth Inhibition, and Modulation of cAMP Signaling by an RNA-DNA Hybrid Antisense Targeted to Protein Kinase A RI sub( alpha ) Subunit AN - 17766702; 4827422 AB - The primary mediator of cAMP action in mammalian cells is cAMP-dependent protein kinase (PKA). There are two types of PKA, type I (PKA-I) and type II (PKA-II), which share a common catalytic subunit but contain distinct regulatory subunits, RI and RII, respectively. Evidence suggests that increased expression of RI sub( alpha )/PKA-I correlates with neoplastic cell growth. Here, we show that sequence-specific oligonucleotide inhibition of RI sub( alpha ) expression results in inhibition of growth and modulation of cAMP signaling in cancer cells. The antisense promoted growth inhibition in a time-dependent, concentration-dependent, and sequence-dependent manner in human cancer cells in monolayer culture, and it inhibited colony formation in soft agar and tumor growth in nude mice. Among the cancer cells are LS-174T, HCT-15, and Colo-205 colon carcinoma cells; A-549 lung carcinoma cells; LNCaP prostate adenocarcinoma cells; Molt-4 leukemia cells; and Jurkat T lymphoma cells. Northern blot and immunoprecipitation analyses revealed that the growth inhibitory effect of the antisense correlated with a decrease in RI sub( alpha ) expression at both the mRNA and protein levels. Pulse-chase experiments revealed that the antisense-directed inhibition of RI sub( alpha ) expression resulted in compensatory changes in expression of the isoforms of R and C subunits and cAMP signaling in a cell type-specific manner. These results demonstrate that cAMP is ubiquitous in the regulation of cell growth and that the antisense oligonucleotide, which inhibits the synthesis of the RI sub( alpha ) subunit of PKA, can be targeted to a single gene for treatment of cancer in a variety of cell types. JF - Antisense and Nucleic Acid Drug Development AU - Nesterova, M AU - Cho-Chung, Y S AD - National Cancer Institute, Building 10, Room 5B05, 9000 Rockville Pike, Bethesda, MD 20892-1750, USA Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 423 EP - 433 VL - 10 IS - 6 SN - 1087-2906, 1087-2906 KW - man KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Protein kinase A KW - Antisense KW - Cyclic AMP KW - Oligonucleotides KW - Cancer KW - N 14560:Antisense research KW - W 30965:Miscellaneous, Reviews KW - W3 33380:Antisense UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17766702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antisense+and+Nucleic+Acid+Drug+Development&rft.atitle=Oligonucleotide+Sequence-Specific+Inhibition+of+Gene+Expression%2C+Tumor+Growth+Inhibition%2C+and+Modulation+of+cAMP+Signaling+by+an+RNA-DNA+Hybrid+Antisense+Targeted+to+Protein+Kinase+A+RI+sub%28+alpha+%29+Subunit&rft.au=Nesterova%2C+M%3BCho-Chung%2C+Y+S&rft.aulast=Nesterova&rft.aufirst=M&rft.date=2000-12-01&rft.volume=10&rft.issue=6&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Antisense+and+Nucleic+Acid+Drug+Development&rft.issn=10872906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Antisense; Cyclic AMP; Protein kinase A; Oligonucleotides; Cancer ER - TY - JOUR T1 - Considerations in developing successful, population-based molecular screening and prevention of lung cancer AN - 1434023970; 18537584 AB - The current mortality rate for lung cancer exceeds 85%, as it has for the last 3 decades. This statistic reflects the utility of the major diagnostic tool that has been used during this period to diagnose lung cancer: the chest X-ray. The overwhelming majority of new cases of lung cancer that are detected with chest X-rays involve individuals who already have regional or distant metastatic disease. Because the systemic treatment of this disease has not improved greatly, patients with metastatic disease rarely are cured. This article reviews the issues involved with the development of sputum-based cellular diagnostics for early stage lung cancer. The biomarker, heterogeneous nuclear ribonucleoprotein A2/B1, is the lead marker for this approach. It has been used in several studies in independent cohorts that have suggested that its overexpression in bronchial epithelial cells is associated highly with the development of lung cancer. This marker is detectable 1 year or more prior to the detection of lung cancer by chest X-ray. Finding this early airway-confined phase of lung cancer may allow for the evolution of new management approaches for very early stage lung cancer. Research activities, such aerosolized chemoprevention, are discussed. Cancer 2000; 89:2465-7. [copy 2000 American Cancer Society. With the high mortality rates for patients with symptomatic lung carcinoma, research efforts to routinely detect lung carcinoma prior to the development of symptoms are a major priority. New tools are required to enable such an approach, and, because this is such a large public health problem, critical analysis of the design considerations is essential to ensure that optimal benefits are achieved. JF - Cancer AU - Mulshine, James L AU - De Luca, Luigi M AU - Dedrick, Robert L AU - Tockman, Melvyn S AU - Webster, Robert AU - Placke, Michael E AD - National Institutes of Health, Bethesda, Maryland. Y1 - 2000/12// PY - 2000 DA - Dec 2000 SP - 2465 EP - 2467 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 89 IS - S11 SN - 0008-543X, 0008-543X KW - Health & Safety Science Abstracts KW - Bioindicators KW - Mortality KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434023970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Considerations+in+developing+successful%2C+population-based+molecular+screening+and+prevention+of+lung+cancer&rft.au=Mulshine%2C+James+L%3BDe+Luca%2C+Luigi+M%3BDedrick%2C+Robert+L%3BTockman%2C+Melvyn+S%3BWebster%2C+Robert%3BPlacke%2C+Michael+E&rft.aulast=Mulshine&rft.aufirst=James&rft.date=2000-12-01&rft.volume=89&rft.issue=S11&rft.spage=2465&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2F1097-0142%2820001201%2989%3A11%2B3.0.CO%3B2-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2014-03-10 N1 - SubjectsTermNotLitGenreText - Mortality DO - http://dx.doi.org/10.1002/1097-0142(20001201)89:11+<2465::AID-CNCR24>3.0.CO;2-6 ER - TY - JOUR T1 - Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. AN - 72410315; 11096166 AB - Neutralization of tumor necrosis factor a (TNF-alpha) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known. We treated 428 patients who had active rheumatoid arthritis despite methotrexate therapy with placebo or infliximab, a chimeric monoclonal antibody against TNF-alpha, in intravenous doses of 3 or 10 mg per kilogram of body weight every 4 or 8 weeks in combination with oral methotrexate for 54 weeks. We assessed clinical responses with use of the criteria of the American College of Rheumatology, the quality of life with a health-status questionnaire, and the effect on joint damage radiographically. The combination of infliximab and methotrexate was well tolerated and resulted in a sustained reduction in the symptoms and signs of rheumatoid arthritis that was significantly greater than the reduction associated with methotrexate therapy alone (clinical response, 51.8 percent vs. 17.0 percent; P<0.001). The quality of life was also significantly better with infliximab plus methotrexate than with methotrexate alone. Radiographic evidence of joint damage increased in the group given methotrexate, but not in the groups given infliximab and methotrexate (mean change in radiographic score, 7.0 vs. 0.6, P<0.001). Radiographic evidence of progression of joint damage was absent in infliximab-treated patients whether or not they had a clinical response. In patients with persistently active rheumatoid arthritis despite methotrexate therapy, repeated doses of infliximab in combination with methotrexate provided clinical benefit and halted the progression of joint damage. JF - The New England journal of medicine AU - Lipsky, P E AU - van der Heijde, D M AU - St Clair, E W AU - Furst, D E AU - Breedveld, F C AU - Kalden, J R AU - Smolen, J S AU - Weisman, M AU - Emery, P AU - Feldmann, M AU - Harriman, G R AU - Maini, R N AU - Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group AD - University of Texas Southwestern Medical Center at Dallas, USA. lipskyp@mail.nih.gov ; Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group Y1 - 2000/11/30/ PY - 2000 DA - 2000 Nov 30 SP - 1594 EP - 1602 VL - 343 IS - 22 SN - 0028-4793, 0028-4793 KW - Antibodies, Monoclonal KW - 0 KW - Antirheumatic Agents KW - Tumor Necrosis Factor-alpha KW - Infliximab KW - B72HH48FLU KW - Methotrexate KW - YL5FZ2Y5U1 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Joints -- pathology KW - Injections, Intravenous KW - Humans KW - Disease Progression KW - Middle Aged KW - Arthrography KW - Male KW - Female KW - Arthritis, Rheumatoid -- drug therapy KW - Methotrexate -- adverse effects KW - Arthritis, Rheumatoid -- physiopathology KW - Antirheumatic Agents -- adverse effects KW - Methotrexate -- therapeutic use KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Antibodies, Monoclonal -- adverse effects KW - Arthritis, Rheumatoid -- diagnostic imaging KW - Antirheumatic Agents -- therapeutic use KW - Arthritis, Rheumatoid -- pathology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72410315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Infliximab+and+methotrexate+in+the+treatment+of+rheumatoid+arthritis.+Anti-Tumor+Necrosis+Factor+Trial+in+Rheumatoid+Arthritis+with+Concomitant+Therapy+Study+Group.&rft.au=Lipsky%2C+P+E%3Bvan+der+Heijde%2C+D+M%3BSt+Clair%2C+E+W%3BFurst%2C+D+E%3BBreedveld%2C+F+C%3BKalden%2C+J+R%3BSmolen%2C+J+S%3BWeisman%2C+M%3BEmery%2C+P%3BFeldmann%2C+M%3BHarriman%2C+G+R%3BMaini%2C+R+N%3BAnti-Tumor+Necrosis+Factor+Trial+in+Rheumatoid+Arthritis+with+Concomitant+Therapy+Study+Group&rft.aulast=Lipsky&rft.aufirst=P&rft.date=2000-11-30&rft.volume=343&rft.issue=22&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-07 N1 - Date created - 2000-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: ACP J Club. 2001 Jul-Aug;135(1):3 N Engl J Med. 2000 Nov 30;343(22):1640-1 [11096174] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues. AN - 72463518; 11111041 AB - Smad1 belongs to a family of receptor-activated proteins which mediate signals from TGF-beta superfamily ligands, including TGF-beta and BMPs. Although much is known about the biochemistry of Smad1 signal transduction, the role of Smad1 in vivo is still unclear. Here we present the first description of the genomic structure of the mouse Smad1 gene and the characterization of its expression pattern in adult mouse tissues by immunohistochemistry. The Smad1 gene contains 7 exons and spans >42 kb of genomic DNA. Its coding region is contained within 6 exons and all introns, except intron 1, follow the GT/AG rule. Immunohistochemical analysis shows that Smad1 is widely expressed in adult mouse tissues, with a varying degree of nuclear localization in different cell types, suggesting a regulated function for this protein. This study assigns all of the exon-intron boundaries of the mouse Smad1 gene and provides the basis for assessing the functional significance of this gene using targeted gene manipulation in the mouse. JF - Gene AU - Huang, S AU - Flanders, K C AU - Roberts, A B AD - Laboratory of Cell Regulation and Carcinogenesis, NCI, 41 Library Drive, Bethesda, MD 20892, USA. Y1 - 2000/11/27/ PY - 2000 DA - 2000 Nov 27 SP - 43 EP - 53 VL - 258 IS - 1-2 SN - 0378-1119, 0378-1119 KW - 5' Untranslated Regions KW - 0 KW - DNA, Complementary KW - DNA-Binding Proteins KW - SMAD1 protein, human KW - Smad Proteins KW - Smad1 Protein KW - Smad1 protein, mouse KW - Trans-Activators KW - DNA KW - 9007-49-2 KW - Index Medicus KW - 5' Untranslated Regions -- genetics KW - Animals KW - DNA, Complementary -- genetics KW - COS Cells KW - Exons KW - Humans KW - Mice KW - Amino Acid Sequence KW - Tissue Distribution KW - Sequence Analysis, DNA KW - Genes -- genetics KW - Base Sequence KW - Sequence Alignment KW - DNA -- genetics KW - Molecular Sequence Data KW - Introns KW - DNA, Complementary -- chemistry KW - DNA -- chemistry KW - Sequence Homology, Amino Acid KW - Immunohistochemistry KW - Male KW - Female KW - Trans-Activators -- metabolism KW - Gene Expression Profiling KW - Trans-Activators -- genetics KW - DNA-Binding Proteins -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72463518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Characterization+of+the+mouse+Smad1+gene+and+its+expression+pattern+in+adult+mouse+tissues.&rft.au=Huang%2C+S%3BFlanders%2C+K+C%3BRoberts%2C+A+B&rft.aulast=Huang&rft.aufirst=S&rft.date=2000-11-27&rft.volume=258&rft.issue=1-2&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2001-01-04 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AF295772; GENBANK; AF295763; AF295771; AF295762; AF295767; AF295766; AF295765; AF295764; AF295768; AF295769; AF295770 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of a functional domain in a GADD45-mediated G2/M checkpoint. AN - 72432494; 10973963 AB - Cell cycle checkpoints are essential for the maintenance of genomic stability in response to DNA damage. We demonstrated recently that GADD45, a DNA damage-inducible protein, activates a G(2)/M checkpoint induced by either UV radiation or alkylating agents. GADD45 can interact in vivo with the G(2) cell cycle-specific kinase, Cdc2, proliferating cell nuclear antigen (PCNA), and the cell cycle kinase inhibitor p21(waf1). The ability of GADD45 to induce a G(2)/M arrest may be caused in part by the inhibition of Cdc2 kinase activity. Here, we report the identification of a region of GADD45 that is involved in this G(2)/M checkpoint. Mutants of GADD45 that lacked either the first 35 or the last 80 residues still retained an ability to induce G(2)/M arrest. A mutant with a deletion of the central region (residues 50-76), which is conserved in the family members GADD45beta and GADD45gamma, lacked such activity. This mutant also lacked an ability to bind to Cdc2, PCNA, and p21(waf1) in vivo. Consistently, either GADD45beta or GADD45gamma bind to Cdc2 in vivo. However, unlike GADD45, neither GADD45beta nor GADD45gamma inhibited the Cdc2 kinase or induced G(2)/M arrest. The unique effect of GADD45 may be caused by the presence of a region containing DEDDDR residues. Alanine substitutions in the region abolished GADD45 induction of a G(2)/M arrest and its inactivation of the Cdc2 kinase but not its binding to Cdc2, PCNA, or p21(waf1). Therefore, the binding of GADD45 to Cdc2 was insufficient to induce a G(2)/M arrest, and additional activity contributed by the DEDDDR residues may be necessary to regulate the G(2)/M checkpoint. JF - The Journal of biological chemistry AU - Yang, Q AU - Manicone, A AU - Coursen, J D AU - Linke, S P AU - Nagashima, M AU - Forgues, M AU - Wang, X W AD - Laboratory of Human Carcinogenesis, DBS, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/11/24/ PY - 2000 DA - 2000 Nov 24 SP - 36892 EP - 36898 VL - 275 IS - 47 SN - 0021-9258, 0021-9258 KW - CCNB1 protein, human KW - 0 KW - CDKN1A protein, human KW - Cyclin B KW - Cyclin B1 KW - Cyclin-Dependent Kinase Inhibitor p21 KW - Cyclins KW - GADD45 protein KW - Intracellular Signaling Peptides and Proteins KW - Proliferating Cell Nuclear Antigen KW - Proteins KW - CDC2 Protein Kinase KW - EC 2.7.11.22 KW - CDC2-CDC28 Kinases KW - Cyclin-Dependent Kinases KW - Index Medicus KW - Peptide Mapping KW - CDC2 Protein Kinase -- metabolism KW - Humans KW - Cyclin B -- metabolism KW - Amino Acid Sequence KW - Mutagenesis, Site-Directed KW - Tumor Cells, Cultured KW - Point Mutation KW - Molecular Sequence Data KW - Cyclin-Dependent Kinases -- antagonists & inhibitors KW - Cyclins -- metabolism KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Amino Acid Substitution KW - Proteins -- chemistry KW - Mitosis KW - G2 Phase KW - Proteins -- metabolism KW - Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72432494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Identification+of+a+functional+domain+in+a+GADD45-mediated+G2%2FM+checkpoint.&rft.au=Yang%2C+Q%3BManicone%2C+A%3BCoursen%2C+J+D%3BLinke%2C+S+P%3BNagashima%2C+M%3BForgues%2C+M%3BWang%2C+X+W&rft.aulast=Yang&rft.aufirst=Q&rft.date=2000-11-24&rft.volume=275&rft.issue=47&rft.spage=36892&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-08 N1 - Date created - 2001-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils. AN - 72432632; 11069287 AB - Senile plaques associated with Alzheimer's disease contain deposits of fibrils formed by 39- to 43-residue beta-amyloid peptides with possible neurotoxic effects. X-ray diffraction measurements on oriented fibril bundles have indicated an extended beta-sheet structure for Alzheimer's beta-amyloid fibrils and other amyloid fibrils, but the supramolecular organization of the beta-sheets and other structural details are not well established because of the intrinsically noncrystalline, insoluble nature of amyloid fibrils. Here we report solid-state NMR measurements, using a multiple quantum (MQ) (13)C NMR technique, that probe the beta-sheet organization in fibrils formed by the full-length, 40-residue beta-amyloid peptide (Abeta(1-40)). Although an antiparallel beta-sheet organization often is assumed and is invoked in recent structural models for full-length beta-amyloid fibrils, the MQNMR data indicate an in-register, parallel organization. This work provides site-specific, atomic-level structural constraints on full-length beta-amyloid fibrils and applies MQNMR to a significant problem in structural biology. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Antzutkin, O N AU - Balbach, J J AU - Leapman, R D AU - Rizzo, N W AU - Reed, J AU - Tycko, R AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. Y1 - 2000/11/21/ PY - 2000 DA - 2000 Nov 21 SP - 13045 EP - 13050 VL - 97 IS - 24 SN - 0027-8424, 0027-8424 KW - Amyloid beta-Peptides KW - 0 KW - Peptide Fragments KW - amyloid beta-protein (1-40) KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Quantum Theory KW - Nuclear Magnetic Resonance, Biomolecular -- methods KW - Humans KW - Dimerization KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Amyloid beta-Peptides -- chemical synthesis KW - Protein Structure, Secondary KW - Peptide Fragments -- chemistry KW - Amyloid beta-Peptides -- ultrastructure KW - Amyloid beta-Peptides -- chemistry KW - Peptide Fragments -- ultrastructure KW - Peptide Fragments -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72432632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Multiple+quantum+solid-state+NMR+indicates+a+parallel%2C+not+antiparallel%2C+organization+of+beta-sheets+in+Alzheimer%27s+beta-amyloid+fibrils.&rft.au=Antzutkin%2C+O+N%3BBalbach%2C+J+J%3BLeapman%2C+R+D%3BRizzo%2C+N+W%3BReed%2C+J%3BTycko%2C+R&rft.aulast=Antzutkin&rft.aufirst=O&rft.date=2000-11-21&rft.volume=97&rft.issue=24&rft.spage=13045&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2000-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 2000 May 26;299(1):225-31 [10860734] J Magn Reson. 1999 Aug;139(2):302-7 [10423367] Biochem Biophys Res Commun. 1984 May 16;120(3):885-90 [6375662] Proc Natl Acad Sci U S A. 1987 Oct;84(19):6953-7 [3477820] Biochemistry. 1990 Mar 20;29(11):2639-44 [2346740] J Mol Biol. 1991 Mar 5;218(1):149-63 [2002499] Biochemistry. 1992 Aug 4;31(30):6865-70 [1637821] Annu Rev Biochem. 1992;61:947-75 [1497327] Biochemistry. 1992 Nov 10;31(44):10716-23 [1420187] J Biol Chem. 1993 Feb 15;268(5):3072-83 [8428986] Biochemistry. 1993 May 11;32(18):4693-7 [8490014] Neuron. 1994 Jul;13(1):45-53 [8043280] J Mol Biol. 1994 Nov 18;244(1):64-73 [7966323] Eur J Biochem. 1995 Oct 1;233(1):293-8 [7588758] Nat Struct Biol. 1995 Nov;2(11):990-8 [7583673] Neuron. 1996 May;16(5):921-32 [8630250] Structure. 1996 Aug 15;4(8):989-98 [8805583] Biopolymers. 1999 Dec;50(7):733-41 [10547528] Biochemistry. 1999 Nov 23;38(47):15514-21 [10569934] Biochemistry. 2000 Mar 28;39(12):3491-9 [10727245] J Mol Biol. 1997 Jun 6;269(2):214-24 [9191066] J Mol Biol. 1997 Oct 31;273(3):729-39 [9356260] Biophys J. 1998 Jan;74(1):537-45 [9449354] Biochemistry. 1998 Feb 17;37(7):1731-5 [9492738] Q Rev Biophys. 1998 Feb;31(1):1-39 [9717197] Protein Eng. 1998 Sep;11(9):761-7 [9796824] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13407-12 [9811813] J Mol Biol. 1999 Jan 15;285(2):755-73 [9878442] Solid State Nucl Magn Reson. 1998 Dec;13(3):149-66 [10023844] EMBO J. 1999 Feb 15;18(4):815-21 [10022824] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3590-4 [10097081] J Biol Chem. 1999 Apr 30;274(18):12619-25 [10212241] Neuropathol Appl Neurobiol. 1999 Apr;25(2):81-97 [10215996] Biophys J. 1999 Jun;76(6):2871-8 [10354415] Biochemistry. 2000 Nov 14;39(45):13748-59 [11076514] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A multi-stage model of adenoma development. AN - 72340552; 11034825 AB - The overwhelming proportion of colorectal carcinomas are believed to originate as adenomatous polyps (adenomas), and the identification and removal of adenomas is an important component of colorectal cancer prevention efforts. Mathematical modeling of adenomas can increase our understanding of the natural history and biology of adenomas and colorectal cancer and can help in the effort to devise optimal prevention and screening strategies. Here we adapt the multi-stage model of carcinogenesis to the problem of the development and growth of adenomas. We show that, using plausible values for the biological parameters, the model can fit various aspects of adenoma data including adenoma prevalence by age, the size distribution of adenomas, clustering of adenomas within individuals and the correlation between distal and proximal adenomas. Explaining the clustering of adenomas within individuals, as well as other findings, requires heterogeneity in risk in the population; we show how such heterogeneity can be related to the distribution of biological parameters in the population. The model can also be adapted to account for adenoma development in two major syndromes related to colorectal cancer, familial adenomatous polyposis and hereditary non-polyposis colorectal cancer. Copyright 2000 Academic Press. JF - Journal of theoretical biology AU - Pinsky, P F AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. Y1 - 2000/11/21/ PY - 2000 DA - 2000 Nov 21 SP - 129 EP - 143 VL - 207 IS - 2 SN - 0022-5193, 0022-5193 KW - Index Medicus KW - Adenomatous Polyposis Coli -- pathology KW - Adenomatous Polyposis Coli -- genetics KW - Apoptosis KW - Humans KW - Colorectal Neoplasms, Hereditary Nonpolyposis -- pathology KW - Colorectal Neoplasms, Hereditary Nonpolyposis -- genetics KW - Cell Death KW - Aging KW - Adult KW - Prognosis KW - Mutation KW - Likelihood Functions KW - Colorectal Neoplasms -- pathology KW - Models, Genetic KW - Colorectal Neoplasms -- genetics KW - Adenoma -- pathology KW - Adenoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72340552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+theoretical+biology&rft.atitle=A+multi-stage+model+of+adenoma+development.&rft.au=Pinsky%2C+P+F&rft.aulast=Pinsky&rft.aufirst=P&rft.date=2000-11-21&rft.volume=207&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Journal+of+theoretical+biology&rft.issn=00225193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatitis C virus lacking the hypervariable region 1 of the second envelope protein is infectious and causes acute resolving or persistent infection in chimpanzees. AN - 70776753; 11078521 AB - Persistent infection with hepatitis C virus (HCV) is among the leading causes of chronic liver disease. Previous studies suggested that genetic variation in hypervariable region 1 (HVR1) of the second envelope protein, possibly in response to host immune pressure, influences the outcome of HCV infection. In the present study, a chimpanzee transfected intrahepatically with RNA transcripts of an infectious HCV clone (pCV-H77C) from which HVR1 was deleted became infected; the DeltaHVR1 virus was subsequently transmitted to a second chimpanzee. Infection with DeltaHVR1 virus resulted in persistent infection in the former chimpanzee and in acute resolving infection in the latter chimpanzee. Both chimpanzees developed hepatitis. The DeltaHVR1 virus initially replicated to low titers, but virus titer increased significantly after mutations appeared in the viral genome. Thus, wild-type HCV without HVR1 was apparently attenuated, suggesting a functional role of HVR1. However, our data indicate that HVR1 is not essential for the viability of HCV, the resolution of infection, or the progression to chronicity. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Forns, X AU - Thimme, R AU - Govindarajan, S AU - Emerson, S U AU - Purcell, R H AU - Chisari, F V AU - Bukh, J AD - Hepatitis Viruses Section and Molecular Hepatitis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/11/21/ PY - 2000 DA - 2000 Nov 21 SP - 13318 EP - 13323 VL - 97 IS - 24 SN - 0027-8424, 0027-8424 KW - HVR1 protein, Hepatitis C virus KW - 0 KW - RNA, Viral KW - Viral Proteins KW - Index Medicus KW - Animals KW - Transfection KW - Biological Evolution KW - Open Reading Frames KW - Genes, env KW - RNA, Viral -- genetics KW - Sequence Deletion KW - Pan troglodytes KW - Mutagenesis KW - Viral Proteins -- genetics KW - Hepacivirus -- pathogenicity KW - Hepacivirus -- genetics KW - Hepatitis C -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70776753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Hepatitis+C+virus+lacking+the+hypervariable+region+1+of+the+second+envelope+protein+is+infectious+and+causes+acute+resolving+or+persistent+infection+in+chimpanzees.&rft.au=Forns%2C+X%3BThimme%2C+R%3BGovindarajan%2C+S%3BEmerson%2C+S+U%3BPurcell%2C+R+H%3BChisari%2C+F+V%3BBukh%2C+J&rft.aulast=Forns&rft.aufirst=X&rft.date=2000-11-21&rft.volume=97&rft.issue=24&rft.spage=13318&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-24 N1 - Date created - 2000-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 Feb;74(4):2046-51 [10644379] Trends Microbiol. 1999 Oct;7(10):402-10 [10498948] Science. 2000 Apr 14;288(5464):339-44 [10764648] J Exp Med. 2000 May 1;191(9):1499-512 [10790425] J Infect Dis. 2000 May;181(5):1528-36 [10823750] Virology. 2000 Aug 15;274(1):75-85 [10936090] Hepatology. 2000 Sep;32(3):618-25 [10960458] Virology. 1991 Feb;180(2):842-8 [1846505] Biochem Biophys Res Commun. 1991 Feb 28;175(1):220-8 [1847805] Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3392-6 [1849654] Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3468-72 [1314389] J Virol. 1993 Jul;67(7):3923-30 [7685404] Virology. 1993 Jul;195(1):297-301 [7686313] J Virol. 1993 Aug;67(8):4557-65 [8331723] J Immunol. 1993 Oct 15;151(8):4189-99 [7691940] J Clin Invest. 1995 Feb;95(2):521-30 [7860734] Virology. 1995 Apr 20;208(2):653-61 [7538251] Semin Liver Dis. 1995 Feb;15(1):41-63 [7597443] Lancet. 1995 Oct 14;346(8981):1006-7 [7475549] Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1759-63 [8700831] J Clin Invest. 1996 Aug 1;98(3):706-14 [8698862] Virology. 1996 Sep 15;223(2):409-12 [8806581] J Infect Dis. 1997 Jan;175(1):26-31 [8985192] Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15394-9 [8986822] J Virol. 1997 May;71(5):4123-7 [9094694] Hepatology. 1997 May;25(5):1245-9 [9141445] Science. 1997 Jul 25;277(5325):570-4 [9228008] Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8738-43 [9238047] Eur J Immunol. 1997 Jul;27(7):1782-7 [9247592] Springer Semin Immunopathol. 1997;19(1):5-26 [9266628] Hepatology. 1997 Sep;26(3 Suppl 1):2S-10S [9305656] J Clin Invest. 1997 Nov 1;100(9):2376-85 [9410918] AIDS. 1997;11 Suppl A:S3-16 [9451961] Virology. 1998 Apr 25;244(1):161-72 [9581788] J Virol. 1998 Jun;72(6):4893-905 [9573256] EMBO J. 1998 Jul 1;17(13):3521-33 [9649423] Gastroenterology. 1998 Oct;115(4):954-65 [9753499] Science. 1998 Oct 30;282(5390):938-41 [9794763] J Infect Dis. 1998 Oct;178(4):1193-7 [9806059] Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2291-5 [10051634] J Virol. 1999 Apr;73(4):2938-46 [10074143] Science. 1999 Apr 30;284(5415):825-9 [10221919] Immunity. 1999 Apr;10(4):439-49 [10229187] J Immunol. 1999 Jul 15;163(2):650-8 [10395654] J Virol. 1999 Aug;73(8):6235-44 [10400713] Virology. 1999 Sep 15;262(1):250-63 [10489358] J Viral Hepat. 1999 Jul;6 Suppl 1:41-6 [10760034] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acquired, nonrandom chromosomal abnormalities associated with the development of acute promyelocytic leukemia in transgenic mice. AN - 70775823; 11087871 AB - We previously generated a transgenic mouse model for acute promyelocytic leukemia (APL) by expressing the promyelocytic leukemia (PML)-retinoic acid receptor (RARalpha) cDNA in early myeloid cells. This fusion protein causes a myeloproliferative disease in 100% of animals, but only 15-20% of the animals develop acute leukemia after a long latency period (6-13 months). PML-RARalpha is therefore necessary, but not sufficient, for APL development. The coexpression of a reciprocal form of the fusion, RARalpha-PML, increased the likelihood of APL development (55-60%), but did not shorten latency. Together, these results suggested that additional genetic events are required for the development of APL. We therefore evaluated the splenic tumor cells from 18 transgenic mice with APL for evidence of secondary genetic events, by using spectral karyotyping analysis. Interstitial or terminal deletions of the distal region of one copy of chromosome 2 [del(2)] were found in 1/5 tumors expressing PML-RARalpha, but in 11/13 tumors expressing both PML-RARalpha and RARalpha-PML (P < 0.05). Leukemic cells that contained a deletion on chromosome 2 often contained additional chromosomal gains (especially of 15), chromosomal losses (especially of 11 or X/Y), or were tetraploid (P p, a product of the tRNA splicing reaction. AN - 72416925; 11080166 AB - The crystal structure of the cyclic phosphodiesterase (CPDase) from Arabidopsis thaliana, an enzyme involved in the tRNA splicing pathway, was determined at 2.5 A resolution. CPDase hydrolyzes ADP-ribose 1",2"-cyclic phosphate (Appr>p), a product of the tRNA splicing reaction, to the monoester ADP-ribose 1"-phosphate (Appr-1"p). The 181 amino acid protein shows a novel, bilobal arrangement of two alphabeta modules. Each lobe consists of two alpha-helices on the outer side of the molecule, framing a three- or four-stranded antiparallel beta-sheet in the core of the protein. The active site is formed at the interface of the two beta-sheets in a water-filled cavity involving residues from two H-X-T/S-X motifs. This previously noticed motif participates in coordination of a sulfate ion. A solvent-exposed surface loop (residues 100-115) is very likely to play a flap-like role, opening and closing the active site. Based on the crystal structure and on recent mutagenesis studies of a homologous CPDase from Saccharomyces cerevisiae, we propose an enzymatic mechanism that employs the nucleophilic attack of a water molecule activated by one of the active site histidines. JF - The EMBO journal AU - Hofmann, A AU - Zdanov, A AU - Genschik, P AU - Ruvinov, S AU - Filipowicz, W AU - Wlodawer, A AD - Protein Structure Section, Macromolecular Crystallography Laboratory, Program in Structural Biology, NCI-Frederick, Frederick, MD 21702, USA. hofmanna@ncifcrf.gov Y1 - 2000/11/15/ PY - 2000 DA - 2000 Nov 15 SP - 6207 EP - 6217 VL - 19 IS - 22 SN - 0261-4189, 0261-4189 KW - RNA, Plant KW - 0 KW - adenosine diphosphate-ribose 1''-2''cyclic phosphate KW - Adenosine Diphosphate Ribose KW - 20762-30-5 KW - RNA, Transfer KW - 9014-25-9 KW - 2',3'-Cyclic-Nucleotide Phosphodiesterases KW - EC 3.1.4.- KW - Index Medicus KW - Models, Molecular KW - RNA Splicing KW - Catalytic Domain KW - Amino Acid Sequence KW - Saccharomyces cerevisiae -- enzymology KW - Saccharomyces cerevisiae -- genetics KW - Arabidopsis -- genetics KW - Arabidopsis -- metabolism KW - RNA, Transfer -- metabolism KW - RNA, Transfer -- genetics KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - RNA, Plant -- genetics KW - Sequence Homology, Amino Acid KW - RNA, Plant -- metabolism KW - Protein Conformation KW - 2',3'-Cyclic-Nucleotide Phosphodiesterases -- metabolism KW - Adenosine Diphosphate Ribose -- analogs & derivatives KW - 2',3'-Cyclic-Nucleotide Phosphodiesterases -- genetics KW - 2',3'-Cyclic-Nucleotide Phosphodiesterases -- chemistry KW - Adenosine Diphosphate Ribose -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72416925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=Structure+and+mechanism+of+activity+of+the+cyclic+phosphodiesterase+of+Appr%26gt%3Bp%2C+a+product+of+the+tRNA+splicing+reaction.&rft.au=Hofmann%2C+A%3BZdanov%2C+A%3BGenschik%2C+P%3BRuvinov%2C+S%3BFilipowicz%2C+W%3BWlodawer%2C+A&rft.aulast=Hofmann&rft.aufirst=A&rft.date=2000-11-15&rft.volume=19&rft.issue=22&rft.spage=6207&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-12-15 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 1FSI; PDB N1 - SuppNotes - Cited By: Crit Rev Neurobiol. 1989;4(3):235-301 [2537684] Nature. 1992 Jan 30;355(6359):472-5 [18481394] Biochemistry. 1990 Jul 3;29(26):6132-8 [2207062] Acta Crystallogr A. 1990 Oct 1;46 ( Pt 10):783-92 [2174243] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Mol Cell Biol. 1991 Nov;11(11):5410-6 [1922054] J Biol Chem. 1992 May 25;267(15):10289-94 [1316896] J Mol Biol. 1993 Jan 5;229(1):105-24 [7678431] Protein Eng. 1993 Jan;6(1):37-40 [8433969] Trends Biochem Sci. 1993 Jan;18(1):31-4 [8438235] Science. 1993 Jul 9;261(5118):206-8 [8392224] J Biol Chem. 1994 Oct 7;269(40):24928-34 [7929175] J Biol Chem. 1996 Dec 6;271(49):31145-53 [8940112] J Biol Chem. 1997 May 16;272(20):13203-10 [9148937] J Biol Chem. 1997 May 16;272(20):13211-9 [9148938] EMBO J. 1997 May 15;16(10):2955-67 [9184239] Nat Struct Biol. 1997 Dec;4(12):973-4 [9406542] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Structure. 1998 Nov 15;6(11):1407-18 [9817843] Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14136-41 [9826666] Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2204-9 [10051619] Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):849-61 [10089316] Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):938-40 [10089341] J Neurochem. 1999 Apr;72(4):1362-71 [10098837] Science. 1999 Nov 5;286(5442):1153-5 [10550052] Cell. 1999 Dec 23;99(7):691-702 [10619423] Nucleic Acids Res. 2000 Apr 15;28(8):1676-83 [10734185] J Mol Biol. 1968 Apr 28;33(2):491-7 [5700707] Cell. 1983 Feb;32(2):547-57 [6186399] Biochemistry. 1983 May 24;22(11):2720-8 [6871157] J Biol Chem. 1983 Oct 10;258(19):11974-80 [6413507] Annu Rev Biophys Bioeng. 1984;13:145-65 [6378067] J Biol Chem. 1986 Feb 25;261(6):2978-86 [3512545] J Biol Chem. 1987 Sep 25;262(27):12994-3000 [3654600] EMBO J. 1999 Jun 1;18(11):3119-32 [10357823] J Biol Chem. 1990 Aug 15;265(23):13553-9 [2199440] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Signal transduction pathways that contribute to increased protein synthesis during T-cell activation. AN - 72407841; 11072066 AB - Protein synthesis rates were maximally stimulated in human lymphocytes by ionomycin and the phorbol ester PMA (I+P), which promotes proliferation, whereas PMA alone, which does not promote proliferation, stimulated protein synthesis to a lesser degree. Three translation-associated activities, eIF4E phosphorylation, eIF2B activity and 4E-BP1 phosphorylation also increased with stimulation by I+P and PMA, but only 4E-BP1 phosphorylation was differentially stimulated by these conditions. Correspondingly, signaling pathways activated in T cells were probed for their connection to these activities. Immunosuppressants FK506 and rapamycin partially blocked the protein synthesis rate increases by I+P stimulation. FK506 had less of an inhibitory effect with PMA stimulation suggesting that its mechanism mostly affected ionomycin-activated signals. I+P and PMA equally stimulated phosphorylation of ERK1/2, but I+P more strongly stimulated Akt, and p70(S6K) phosphorylation. An inhibitor that blocks ERK1/2 phosphorylation only slightly reduced protein synthesis rates stimulated by I+P or PMA, but greatly reduced eIF4E phosphorylation and eIF2B activity. In contrast, inhibitors of the PI-3 kinase and mTOR pathways strongly blocked early protein synthesis rate stimulated by I+P and PMA and also blocked 4E-BP1 phosphorylation and release of eIF4E suggesting that these pathways regulate protein synthesis activities, which are important for proliferation in T cells. JF - Biochimica et biophysica acta AU - Miyamoto, S AU - Kimball, S R AU - Safer, B AD - Molecular Hematology Branch, NHLBI, Bethesda, MD 20892-1654, USA. smiyamot@ucdavis.edu Y1 - 2000/11/15/ PY - 2000 DA - 2000 Nov 15 SP - 28 EP - 42 VL - 1494 IS - 1-2 SN - 0006-3002, 0006-3002 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Androstadienes KW - Carrier Proteins KW - EIF4EBP1 protein, human KW - Eukaryotic Initiation Factor-2B KW - Eukaryotic Initiation Factor-4E KW - Peptide Initiation Factors KW - Phosphoproteins KW - Proto-Oncogene Proteins KW - Ionomycin KW - 56092-81-0 KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - AKT1 protein, human KW - EC 2.7.11.1 KW - Protein-Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - Ribosomal Protein S6 Kinases KW - Protein Kinase C KW - EC 2.7.11.13 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Sirolimus KW - W36ZG6FT64 KW - Tacrolimus KW - WM0HAQ4WNM KW - wortmannin KW - XVA4O219QW KW - Index Medicus KW - Humans KW - Proto-Oncogene Proteins -- metabolism KW - Ionomycin -- pharmacology KW - Models, Biological KW - Peptide Initiation Factors -- metabolism KW - Ribosomal Protein S6 Kinases -- metabolism KW - Phosphoproteins -- metabolism KW - MAP Kinase Signaling System -- drug effects KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Androstadienes -- pharmacology KW - Phosphorylation -- drug effects KW - Protein Kinase C -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Eukaryotic Initiation Factor-2B -- metabolism KW - Cells, Cultured KW - Kinetics KW - Tacrolimus -- pharmacology KW - Sirolimus -- pharmacology KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Phosphatidylinositol 3-Kinases -- antagonists & inhibitors KW - Lymphocyte Activation -- drug effects KW - Protein Biosynthesis -- drug effects KW - T-Lymphocytes -- metabolism KW - Signal Transduction -- drug effects KW - T-Lymphocytes -- drug effects KW - T-Lymphocytes -- immunology KW - T-Lymphocytes -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72407841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Signal+transduction+pathways+that+contribute+to+increased+protein+synthesis+during+T-cell+activation.&rft.au=Miyamoto%2C+S%3BKimball%2C+S+R%3BSafer%2C+B&rft.aulast=Miyamoto&rft.aufirst=S&rft.date=2000-11-15&rft.volume=1494&rft.issue=1-2&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. AN - 72401531; 11069970 AB - Chronic alcohol consumption produces a painful peripheral neuropathy for which there is no reliably successful therapy, attributable to, in great part, a lack of understanding of the underlying mechanisms. We tested the hypothesis that neuropathic pain associated with chronic alcohol consumption is a result of abnormal peripheral nociceptor function. In rats maintained on a diet to simulate chronic alcohol consumption in humans, mechanical hyperalgesia was present by the fourth week and maximal at 10 weeks. Thermal hyperalgesia and mechanical allodynia were also present. Mechanical threshold of C-fibers in ethanol fed rats was lowered, and the number of action potentials during sustained stimulation increased. The hyperalgesia was acutely attenuated by intradermal injection of nonselective protein kinase C (PKC) or selective PKCepsilon inhibitors injected at the site of nociceptive testing. Western immunoblot analysis indicated a higher level of PKCepsilon in dorsal root ganglia from alcohol-fed rats, supporting a role for enhanced PKCepsilon second-messenger signaling in nociceptors contributing to alcohol-induced hyperalgesia. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Dina, O A AU - Barletta, J AU - Chen, X AU - Mutero, A AU - Martin, A AU - Messing, R O AU - Levine, J D AD - Departments of Medicine and Oral and Maxillofacial Surgery, Division of Neuroscience and Biomedical Sciences Program, National Institutes of Health Pain Center (UCSF), University of California at San Francisco, San Francisco, California 94143-0440, USA. Y1 - 2000/11/15/ PY - 2000 DA - 2000 Nov 15 SP - 8614 EP - 8619 VL - 20 IS - 22 KW - Isoenzymes KW - 0 KW - Ethanol KW - 3K9958V90M KW - Prkce protein, rat KW - EC 2.7.1.- KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C-epsilon KW - Index Medicus KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Reaction Time -- drug effects KW - Nerve Fibers -- drug effects KW - Animals KW - Drug Administration Schedule KW - Energy Intake -- physiology KW - Ethanol -- administration & dosage KW - Action Potentials KW - Disease Models, Animal KW - Rats KW - Ethanol -- blood KW - Hot Temperature KW - Rats, Sprague-Dawley KW - Pain Threshold -- drug effects KW - Body Weight -- drug effects KW - Pain Measurement -- drug effects KW - Ethanol -- toxicity KW - Physical Stimulation KW - Male KW - Hyperalgesia -- chemically induced KW - Protein Kinase C -- metabolism KW - Alcoholic Neuropathy -- enzymology KW - Ganglia, Spinal -- metabolism KW - Alcoholic Neuropathy -- chemically induced KW - Ganglia, Spinal -- drug effects KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72401531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Key+role+for+the+epsilon+isoform+of+protein+kinase+C+in+painful+alcoholic+neuropathy+in+the+rat.&rft.au=Dina%2C+O+A%3BBarletta%2C+J%3BChen%2C+X%3BMutero%2C+A%3BMartin%2C+A%3BMessing%2C+R+O%3BLevine%2C+J+D&rft.aulast=Dina&rft.aufirst=O&rft.date=2000-11-15&rft.volume=20&rft.issue=22&rft.spage=8614&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2000-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Progression from acute to chronic disease in a murine parent-into-F1 model of graft-versus-host disease. AN - 72400187; 11067962 AB - The parent-into-immunocompetent-F(1) model of graft-vs-host disease (GVHD) induces immune dysregulation, resulting in acute or chronic GVHD. The disease outcome is thought to be determined by the number of parental anti-F(1) CTL precursor cells present in the inoculum. Injection of C57BL/6 (B6) splenocytes into (B6 x DBA/2)F(1) (B6D2F(1)) mice (acute model) leads to extensive parental cell engraftment and early death, whereas injection of DBA/2 cells (chronic model) results in little parental cell engraftment and a lupus-like disease. This study demonstrated that injection of BALB/c splenocytes into (BALB/c x B6)F(1) (CB6F(1)) mice resulted in little engraftment of parental lymphocytes and the development of lupus as expected. Injection of B6 splenocytes into CB6F(1) initiated an initial burst of parental cell engraftment similar to that of B6 into B6D2F(1). However, the acute disease resolved, and the CB6F(1) mice went on to develop chronic GVHD with detectable Abs to ssDNA, dsDNA, and extractable nuclear Ags. Limiting dilution CTL assays determined that B6 splenocytes have CTL precursor frequencies of 1/1000 against both CB6F(1) and B6D2F(1), whereas DBA/2 and BALB/c splenocytes have a CTL precursor frequency of 1/20,000 for their respective F(1)s. The Th cell precursor frequency for B6 anti-DBA/2 was 3-fold higher than that for B6 anti-BALB/c determined by limiting dilution proliferation assays. These results indicate the importance of adequate allospecific helper as well as effector T cells for the induction and maintenance of acute GVHD in this model, and presents an unexpected model in which initial acute GVHD is replaced by the chronic form of disease. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Tschetter, J R AU - Mozes, E AU - Shearer, G M AD - Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/11/15/ PY - 2000 DA - 2000 Nov 15 SP - 5987 EP - 5994 VL - 165 IS - 10 SN - 0022-1767, 0022-1767 KW - H-2 Antigens KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Animals KW - Disease Progression KW - Stem Cells -- pathology KW - Spleen -- pathology KW - Disease Models, Animal KW - H-2 Antigens -- immunology KW - T-Lymphocytes, Cytotoxic -- immunology KW - Mice KW - Mice, Inbred BALB C KW - T-Lymphocytes, Helper-Inducer -- immunology KW - T-Lymphocytes, Cytotoxic -- pathology KW - Mice, Inbred DBA KW - Autoimmune Diseases -- genetics KW - Lymphocyte Activation KW - Stem Cells -- immunology KW - Mice, Inbred C57BL KW - Spleen -- immunology KW - Cytotoxicity Tests, Immunologic KW - Chronic Disease KW - Species Specificity KW - Female KW - Spleen -- transplantation KW - Graft vs Host Disease -- pathology KW - Graft vs Host Disease -- immunology KW - Crosses, Genetic KW - Graft vs Host Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72400187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Progression+from+acute+to+chronic+disease+in+a+murine+parent-into-F1+model+of+graft-versus-host+disease.&rft.au=Tschetter%2C+J+R%3BMozes%2C+E%3BShearer%2C+G+M&rft.aulast=Tschetter&rft.aufirst=J&rft.date=2000-11-15&rft.volume=165&rft.issue=10&rft.spage=5987&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Microarray Explorer tool for data mining of cDNA microarrays: application for the mammary gland AN - 17763557; 4824748 AB - The Microarray Explorer (MAExplorer) is a versatile Java-based data mining bioinformatic tool for analyzing quantitative cDNA expression profiles across multiple microarray platforms and DNA labeling systems. It may be run as either a stand-alone application or as a Web browser applet over the Internet. With this program it is possible to (i) analyze the expression of individual genes, (ii) analyze the expression of gene families and clusters, (iii) compare expression patterns and (iv) directly access other genomic databases for clones of interest. Data may be downloaded as required from a Web server or in the case of the stand-alone version, reside on the user's computer. Analyses are performed in real-time and may be viewed and directly manipulated in images, reports, scatter plots, histograms, expression profile plots and cluster analyses plots. A key feature is the clone data filter for constraining a working set of clones to those passing a variety of user-specified logical and statistical tests. Reports may be generated with hypertext Web access to UniGene, GenBank and other Internet databases for sets of clones found to be of interest. Users may save their explorations on the Web server or local computer and later recall or share them with other scientists in this groupware Web environment. The emphasis on direct manipulation of clones and sets of clones in graphics and tables provides a high level of interaction with the data, making it easier for investigators to test ideas when looking for patterns. We have used the MAExplorer to profile gene expression patterns of 1500 duplicated genes isolated from mouse mammary tissue. We have identified genes that are preferentially expressed during pregnancy and during lactation. One gene we identified, carbonic anhydrase III, is highly expressed in mammary tissue from virgin and pregnant mice and in gene knock-out mice with underdeveloped mammary epithelium. Other genes, which include those encoding milk proteins, are preferentially expressed during lactation. MAExplorer may be accessed at http://www.lecb.ncifcrf.gov/MAExplorer. JF - Nucleic Acids Research AU - Lemkin, P F AU - Thornwall, G C AU - Walton, K D AU - Hennighausen, L AD - Laboratory of Experimental and Computational Biology, NCI, FCRDC, Frederick, MD 21702, USA, lemkin@ncifcrf.gov Y1 - 2000/11/15/ PY - 2000 DA - 2000 Nov 15 SP - 4452 EP - 4459 VL - 28 IS - 22 SN - 0305-1048, 0305-1048 KW - mice KW - DNA microarrays KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Mammary gland KW - Carbonate dehydratase KW - Gene families KW - Lactation KW - Gene expression KW - cDNA KW - Gene clusters KW - Bioinformatics KW - N 14510:Occurrence, isolation & assay KW - W3 33385:DNA/RNA KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17763557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+Microarray+Explorer+tool+for+data+mining+of+cDNA+microarrays%3A+application+for+the+mammary+gland&rft.au=Lemkin%2C+P+F%3BThornwall%2C+G+C%3BWalton%2C+K+D%3BHennighausen%2C+L&rft.aulast=Lemkin&rft.aufirst=P&rft.date=2000-11-15&rft.volume=28&rft.issue=22&rft.spage=4452&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mammary gland; Gene families; Gene clusters; Carbonate dehydratase; Lactation; Bioinformatics; cDNA; Gene expression ER - TY - JOUR T1 - A case for sliding SeqA tracts at anchored replication forks during Escherichia coli chromosome replication and segregation AN - 17743292; 4809191 AB - SeqA is an Escherichia coli DNA-binding protein that acts at replication origins and controls DNA replication. However, binding is not exclusive to origins. Many fragments containing two or more hemi-methylated GATC sequences bind efficiently. Binding was optimal when two such sequences were closely apposed or up to 31 bases apart on the same face of the DNA helix. Binding studies suggest that neighboring bound proteins contact each other to form a complex with the intervening DNA looped out. There are many potential binding sites distributed around the E.coli chromosome. As replication produces a transient wave of hemi- methylation, tracts of SeqA binding are likely to associate with each fork as replication progresses. The number and positions of green fluorescent protein-SeqA foci seen in living cells suggest that they correspond to these tracts, and that the forks are tethered to planes of cell division. SeqA may help to tether the forks or to organize newly replicated DNA into a structure that aids DNA to segregate away from the replication machinery. JF - EMBO Journal AU - Brendler, T AU - Sawitzke, J AU - Sergueev, K AU - Austin, S AD - Gene Regulation and Chromosome Biology Laboratory, Division of Basic Sciences, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702-1201, USA, austin@ncifcrf.gov Y1 - 2000/11/15/ PY - 2000 DA - 2000 Nov 15 SP - 6249 EP - 6258 VL - 19 IS - 22 SN - 0261-4189, 0261-4189 KW - SeqA protein KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - DNA biosynthesis KW - Chromosomes KW - Replication forks KW - DNA-binding protein KW - Escherichia coli KW - J 02725:DNA KW - N 14650:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17743292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=A+case+for+sliding+SeqA+tracts+at+anchored+replication+forks+during+Escherichia+coli+chromosome+replication+and+segregation&rft.au=Brendler%2C+T%3BSawitzke%2C+J%3BSergueev%2C+K%3BAustin%2C+S&rft.aulast=Brendler&rft.aufirst=T&rft.date=2000-11-15&rft.volume=19&rft.issue=22&rft.spage=6249&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; DNA biosynthesis; Replication forks; Chromosomes; DNA-binding protein ER - TY - JOUR T1 - Characterization of the repressor function of the nuclear orphan receptor retinoid receptor-related testis-associated receptor/germ cell nuclear factor. AN - 72394299; 10940306 AB - Retinoid receptor-related testis-associated receptor (RTR)/germ cell nuclear factor is a nuclear orphan receptor that plays an important role in the control of gene expression during early embryonic development and gametogenesis. It has been shown to repress transcriptional activation. In this study, we further characterize this repressor function. We demonstrate that RTR can suppress the transcriptional activation induced by the estrogen receptor related-receptor alpha1 through its response element. The latter is at least in part due to competition for binding to the same response element. In addition, RTR inhibits basal transcriptional activation, indicating that it functions as an active repressor. Mammalian two-hybrid analyses showed that RTR interacts with the co-repressor nuclear co-repressor (N-CoR) but is unable to interact with the co-repressor SMRT or RIP140. Pull-down analyses with glutathione S-transferase-RTR fusion protein demonstrated that RTR physically interacts with N-CoR in vitro, suggesting a potential role for N-CoR in the transcriptional repression by RTR. To identify the regions in RTR essential for the binding of RTR to N-CoR, the effect of various deletion and point mutations on this interaction was examined. This analysis revealed that this interaction requires the hinge domain, helix 3 as well as the helix 12 region of RTR. The residues Ser(246)-Tyr(247) in the hinge domain, Lys(318) in helix 3, and Lys(489)-Thr(490) in helix 12 are identified as being critical in this interaction. Our results demonstrate that RTR can function as an active transcriptional repressor and that this repression can be mediated through interactions with the co-repressor N-CoR. We show that this interaction exhibits several characteristics unique to RTR. Through its repressor function, RTR can suppress the induction of transcriptional activation by other nuclear receptors. These repressor activities may provide important mechanisms by which RTR regulates gene expression during development and gametogenesis. JF - The Journal of biological chemistry AU - Yan, Z AU - Jetten, A M AD - Cell Biology Section, Laboratory of Pulmonary Pathobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2000/11/10/ PY - 2000 DA - 2000 Nov 10 SP - 35077 EP - 35085 VL - 275 IS - 45 SN - 0021-9258, 0021-9258 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - DNA-Binding Proteins KW - ERRalpha estrogen-related receptor KW - Nuclear Proteins KW - Nuclear Receptor Co-Repressor 1 KW - Nuclear Receptor Co-Repressor 2 KW - Nuclear Receptor Subfamily 6, Group A, Member 1 KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Estrogen KW - Receptors, Retinoic Acid KW - Recombinant Fusion Proteins KW - Repressor Proteins KW - nuclear receptor interacting protein 1 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Animals KW - Electrophoresis, Polyacrylamide Gel KW - Cell Nucleus -- metabolism KW - Two-Hybrid System Techniques KW - Repressor Proteins -- metabolism KW - Transcription, Genetic KW - Mutagenesis, Site-Directed KW - Recombinant Fusion Proteins -- metabolism KW - Molecular Sequence Data KW - Point Mutation KW - CHO Cells KW - Sequence Homology, Amino Acid KW - Nuclear Proteins -- metabolism KW - Response Elements KW - Plasmids -- metabolism KW - Glutathione Transferase -- metabolism KW - Amino Acid Sequence KW - Receptors, Estrogen -- metabolism KW - Protein Binding KW - Transcriptional Activation KW - Gene Deletion KW - Protein Structure, Tertiary KW - Gene Expression Regulation, Developmental KW - Cricetinae KW - Receptors, Retinoic Acid -- metabolism KW - DNA-Binding Proteins -- chemistry KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- chemistry KW - Receptors, Retinoic Acid -- chemistry KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72394299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Characterization+of+the+repressor+function+of+the+nuclear+orphan+receptor+retinoid+receptor-related+testis-associated+receptor%2Fgerm+cell+nuclear+factor.&rft.au=Yan%2C+Z%3BJetten%2C+A+M&rft.aulast=Yan&rft.aufirst=Z&rft.date=2000-11-10&rft.volume=275&rft.issue=45&rft.spage=35077&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oxidants, oxidative stress and the biology of ageing. AN - 72426357; 11089981 AB - Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span. JF - Nature AU - Finkel, T AU - Holbrook, N J AD - Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute/National Institutes of Health, Bethesda, Maryland 20892-1622, USA. finkelt@nih.gov Y1 - 2000/11/09/ PY - 2000 DA - 2000 Nov 09 SP - 239 EP - 247 VL - 408 IS - 6809 SN - 0028-0836, 0028-0836 KW - Oxidants KW - 0 KW - Reactive Oxygen Species KW - Index Medicus KW - Animals KW - Humans KW - Cell Aging -- physiology KW - Energy Intake KW - Signal Transduction KW - Longevity KW - Aging -- physiology KW - Oxidative Stress KW - Oxidants -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72426357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Oxidants%2C+oxidative+stress+and+the+biology+of+ageing.&rft.au=Finkel%2C+T%3BHolbrook%2C+N+J&rft.aulast=Finkel&rft.aufirst=T&rft.date=2000-11-09&rft.volume=408&rft.issue=6809&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-14 N1 - Date created - 2000-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. AN - 72399204; 11050162 AB - Hemochromatosis and Wilson disease (WD), characterized by the excess hepatic deposition of iron and copper, respectively, produce oxidative stress and increase the risk of liver cancer. Because the frequency of p53 mutated alleles in nontumorous human tissue may be a biomarker of oxyradical damage and identify individuals at increased cancer risk, we have determined the frequency of p53 mutated alleles in nontumorous liver tissue from WD and hemochromatosis patients. When compared with the liver samples from normal controls, higher frequencies of G:C to T:A transversions at codon 249 (P < 0.001) and C:G to A:T transversions and C:G to T:A transitions at codon 250 (P < 0.001 and P < 0.005) were found in liver tissue from WD cases, and a higher frequency of G:C to T:A transversions at codon 249 (P < 0.05) also was found in liver tissue from hemochromatosis cases. Sixty percent of the WD and 28% of hemochromatosis cases also showed a higher expression of inducible nitric oxide synthase in the liver, which suggests nitric oxide as a source of increased oxidative stress. A high level of etheno-DNA adducts, formed from oxyradical-induced lipid peroxidation, in liver from WD and hemochromatosis patients has been reported previously. Therefore, we exposed a wild-type p53 TK-6 lymphoblastoid cell line to 4-hydroxynonenal, an unsaturated aldehyde involved in lipid peroxidation, and observed an increase in G to T transversions at p53 codon 249 (AGG to AGT). These results are consistent with the hypothesis that the generation of oxygen/nitrogen species and unsaturated aldehydes from iron and copper overload in hemochromatosis and WD causes mutations in the p53 tumor suppressor gene. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Hussain, S P AU - Raja, K AU - Amstad, P A AU - Sawyer, M AU - Trudel, L J AU - Wogan, G N AU - Hofseth, L J AU - Shields, P G AU - Billiar, T R AU - Trautwein, C AU - Hohler, T AU - Galle, P R AU - Phillips, D H AU - Markin, R AU - Marrogi, A J AU - Harris, C C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/11/07/ PY - 2000 DA - 2000 Nov 07 SP - 12770 EP - 12775 VL - 97 IS - 23 SN - 0027-8424, 0027-8424 KW - Aldehydes KW - 0 KW - Free Radicals KW - HFE protein, human KW - HLA Antigens KW - Hemochromatosis Protein KW - Histocompatibility Antigens Class I KW - Membrane Proteins KW - Tumor Suppressor Protein p53 KW - Copper KW - 789U1901C5 KW - Iron KW - E1UOL152H7 KW - NOS2 protein, human KW - EC 1.14.13.39 KW - Nitric Oxide Synthase KW - Nitric Oxide Synthase Type II KW - 4-hydroxy-2-nonenal KW - K1CVM13F96 KW - Index Medicus KW - Animals KW - HLA Antigens -- genetics KW - Mutagenesis -- drug effects KW - Humans KW - Copper -- metabolism KW - Rabbits KW - Histocompatibility Antigens Class I -- genetics KW - Aldehydes -- pharmacology KW - Iron -- metabolism KW - Nitric Oxide Synthase -- biosynthesis KW - Cell Line KW - Genes, MHC Class I KW - Hepatolenticular Degeneration -- genetics KW - Liver -- pathology KW - Hemochromatosis -- pathology KW - Hepatolenticular Degeneration -- pathology KW - Liver -- metabolism KW - Tumor Suppressor Protein p53 -- genetics KW - Hemochromatosis -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72399204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Increased+p53+mutation+load+in+nontumorous+human+liver+of+wilson+disease+and+hemochromatosis%3A+oxyradical+overload+diseases.&rft.au=Hussain%2C+S+P%3BRaja%2C+K%3BAmstad%2C+P+A%3BSawyer%2C+M%3BTrudel%2C+L+J%3BWogan%2C+G+N%3BHofseth%2C+L+J%3BShields%2C+P+G%3BBilliar%2C+T+R%3BTrautwein%2C+C%3BHohler%2C+T%3BGalle%2C+P+R%3BPhillips%2C+D+H%3BMarkin%2C+R%3BMarrogi%2C+A+J%3BHarris%2C+C+C&rft.aulast=Hussain&rft.aufirst=S&rft.date=2000-11-07&rft.volume=97&rft.issue=23&rft.spage=12770&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13312-7 [10557317] Mol Pharmacol. 1993 Jul;44(1):222-7 [8393522] IARC Sci Publ. 1999;(150):295-302 [10626229] Tumour Biol. 2000 Mar-Apr;21(2):90-7 [10686538] J Biol Chem. 2000 Apr 14;275(15):10954-61 [10753895] J Clin Pathol. 1968 Jan;21(1):8-11 [5697340] Arch Pathol. 1969 Apr;87(4):370-9 [5766764] Nature. 1978 Aug 24;274(5673):775-80 [355893] Science. 1985 Jan 25;227(4685):375-81 [2981433] N Engl J Med. 1985 Nov 14;313(20):1256-62 [4058506] Liver. 1986 Apr;6(2):111-7 [3736354] Annu Rev Genet. 1986;20:201-30 [3545059] Bull Cancer. 1990;77(5):501-2 [2400824] Nature. 1991 Jan 31;349(6308):431-4 [1992344] Cancer Cells. 1991 Jan;3(1):1-7 [2025490] Nature. 1991 Jun 6;351(6326):453-6 [2046748] Science. 1991 Jul 5;253(5015):49-53 [1905840] Science. 1991 Nov 15;254(5034):1001-3 [1948068] Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3030-4 [1557408] Liver. 1992 Feb;12(1):42-5 [1314321] Ann N Y Acad Sci. 1992 Nov 21;663:158-66 [1482049] Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8586-90 [8397412] Nat Genet. 1993 Dec;5(4):327-37 [8298639] Science. 1994 May 27;264(5163):1317-9 [8191284] Oncogene. 1994 Aug;9(8):2277-81 [8036011] Free Radic Biol Med. 1994 Mar;16(3):393-7 [8063202] Cancer Res. 1994 Sep 15;54(18):4855-78 [8069852] Nat Genet. 1994 Aug;7(4):541-5 [7951327] Gastroenterology. 1994 Dec;107(6):1788-98 [7958693] Hum Exp Toxicol. 1994 Dec;13(12):910-2 [7718314] J Clin Invest. 1995 Sep;96(3):1653-7 [7657835] Carcinogenesis. 1995 Sep;16(9):2045-50 [7554052] Chem Res Toxicol. 1995 Apr-May;8(3):473-7 [7578935] Semin Liver Dis. 1996 Feb;16(1):3-12 [8723319] Nat Genet. 1996 Aug;13(4):399-408 [8696333] Chem Res Toxicol. 1997 Apr;10(4):386-92 [9114974] J Biol Chem. 1997 Aug 1;272(31):19095-8 [9235895] Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2492-7 [9482913] Drug Metab Rev. 1998 May;30(2):313-26 [9606606] Cancer Epidemiol Biomarkers Prev. 1998 May;7(5):435-40 [9610794] Mutat Res. 1998 May 25;400(1-2):99-115 [9685598] J Natl Cancer Inst. 1999 Jan 6;91(1):86-8 [9890175] Adv Intern Med. 1999;44:91-116 [9929706] Mutat Res. 1999 Mar 8;424(1-2):23-36 [10064847] Mutat Res. 1999 Mar 8;424(1-2):37-49 [10064848] Mutat Res. 1999 Mar 8;424(1-2):59-69 [10064850] Mutat Res. 1999 Mar 8;424(1-2):83-95 [10064852] Met Ions Biol Syst. 1999;36:179-209 [10093925] J Lab Clin Med. 1999 May;133(5):451-60 [10235128] Arch Pathol Lab Med. 1999 Apr;123(4):310-6 [10320143] J Cancer Res Clin Oncol. 1999;125(6):321-6 [10363563] Gastroenterology. 1999 Jul;117(1):154-60 [10381922] Nat Genet. 1999 Aug;22(4):325-6 [10431233] N Engl J Med. 1999 Sep 2;341(10):725-32 [10471458] IARC Sci Publ. 1999;(150):1-16 [10626204] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial. AN - 72402839; 11075769 AB - High-dose cyclophosphamide has been proposed as an alternative immunosuppressive agent for treatment of severe aplastic anaemia, with a response rate similar to that with regimens containing antithymocyte globulin (ATG) but neither relapse nor clonal haematological complications. We undertook a phase III, prospective, randomised trial to compare response rates to immunosuppression with either high-dose cyclophosphamide plus cyclosporin or conventional immunosuppression with ATG plus cyclosporin in previously untreated patients. Between June, 1997, and March, 2000, 31 patients were enrolled. 15 were assigned cyclophosphamide (1 h intravenous infusion of 50 mg/kg daily for 4 days) and 16 were assigned ATG (40 mg/kg daily for 4 days); both groups received cyclosporin, initially at 12 mg/kg daily with adjustment to maintain concentrations at 200-400 microg/L, for 6 months. The primary endpoint was haematological response (no longer meeting criteria for severe aplastic anaemia). The trial was terminated prematurely after three early deaths in the cyclophosphamide group. Analyses were by intention to treat. Median follow-up was 21.9 months (range 1-33). There was excess morbidity in the cyclophosphamide group (invasive fungal infections, four cyclophosphamide vs no ATG patients; p=0.043) as well as excess early mortality (three deaths within the first 3 months cyclophosphamide vs no ATG patients; p=0.101). There was no significant difference at 6 months after treatment in the overall response rates among evaluable patients (six of 13 [46%] cyclophosphamide vs nine of 12 [75%] ATG). A longer period of observation will be necessary to assess the secondary endpoints of relapse and late clonal complications as well as disease-free and overall survival. However, cyclophosphamide seems a dangerous choice for treatment of this disorder, given the good results achievable with standard therapy. JF - Lancet (London, England) AU - Tisdale, J F AU - Dunn, D E AU - Geller, N AU - Plante, M AU - Nunez, O AU - Dunbar, C E AU - Barrett, A J AU - Walsh, T J AU - Rosenfeld, S J AU - Young, N S AD - Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. johntis@intra.niddk.nih.gov Y1 - 2000/11/04/ PY - 2000 DA - 2000 Nov 04 SP - 1554 EP - 1559 VL - 356 IS - 9241 SN - 0140-6736, 0140-6736 KW - Antilymphocyte Serum KW - 0 KW - Immunosuppressive Agents KW - Cyclosporine KW - 83HN0GTJ6D KW - Cyclophosphamide KW - 8N3DW7272P KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Mycoses -- etiology KW - Cyclophosphamide -- administration & dosage KW - Cyclosporine -- administration & dosage KW - Cyclophosphamide -- therapeutic use KW - Anemia, Aplastic -- mortality KW - Cyclosporine -- therapeutic use KW - Anemia, Aplastic -- drug therapy KW - Antilymphocyte Serum -- administration & dosage KW - Immunosuppressive Agents -- therapeutic use KW - Antilymphocyte Serum -- therapeutic use KW - Immunosuppressive Agents -- adverse effects KW - Immunosuppressive Agents -- administration & dosage KW - Cyclophosphamide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72402839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=High-dose+cyclophosphamide+in+severe+aplastic+anaemia%3A+a+randomised+trial.&rft.au=Tisdale%2C+J+F%3BDunn%2C+D+E%3BGeller%2C+N%3BPlante%2C+M%3BNunez%2C+O%3BDunbar%2C+C+E%3BBarrett%2C+A+J%3BWalsh%2C+T+J%3BRosenfeld%2C+S+J%3BYoung%2C+N+S&rft.aulast=Tisdale&rft.aufirst=J&rft.date=2000-11-04&rft.volume=356&rft.issue=9241&rft.spage=1554&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=01406736&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-01 N1 - Date created - 2000-12-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Lancet. 2001 Apr 7;357(9262):1128-9 [11303606] Lancet. 2000 Nov 4;356(9241):1536-7 [11075760] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Calcium-dependent threonine phosphorylation of nonmuscle myosin in stimulated RBL-2H3 mast cells. AN - 72368378; 10945986 AB - Stimulation of RBL-2H3 m1 mast cells through the IgE receptor with antigen, or through a G protein-coupled receptor with carbachol, leads to the rapid appearance of phosphothreonine in nonmuscle myosin heavy chain II-A (NMHC-IIA). We demonstrate that this results from phosphorylation of Thr-1940 by calcium/calmodulin-dependent protein kinase II (CaM kinase II), activated by increased intracellular calcium. The phosphorylation site in rodent NMHC-IIA was localized to the carboxyl terminus of NMHC-IIA distal to the coiled-coil region, and identified as Thr-1940 by site-directed mutagenesis. A fusion protein containing the NMHC-IIA carboxyl terminus was phosphorylated by CaM kinase II in vitro, while mutation of Thr-1940 to Ala eliminated phosphorylation. In contrast to rodents, in humans Thr-1940 is replaced by Ala, and human NMHC-IIA fusion protein was not phosphorylated by CaM kinase II unless Ala-1940 was mutated to Thr. Similarly, co-transfected Ala --> Thr-1940 human NMHC-IIA was phosphorylated by activated CaM kinase II in HeLa cells, while wild type was not. In RBL-2H3 m1 cells, inhibition of CaM kinase II decreased Thr-1940 phosphorylation, and inhibited release of the secretory granule marker hexosaminidase in response to carbachol but not to antigen. These data indicate a role for CaM kinase stimulation and resultant threonine phosphorylation of NMHC-IIA in RBL-2H3 m1 cell activation. JF - The Journal of biological chemistry AU - Buxton, D B AU - Adelstein, R S AD - Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. db225a@nih.gov Y1 - 2000/11/03/ PY - 2000 DA - 2000 Nov 03 SP - 34772 EP - 34779 VL - 275 IS - 44 SN - 0021-9258, 0021-9258 KW - DNA Primers KW - 0 KW - Enzyme Inhibitors KW - Threonine KW - 2ZD004190S KW - Ionomycin KW - 56092-81-0 KW - Calcium-Calmodulin-Dependent Protein Kinase Type 2 KW - EC 2.7.11.17 KW - Calcium-Calmodulin-Dependent Protein Kinases KW - Myosins KW - EC 3.6.4.1 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium-Calmodulin-Dependent Protein Kinases -- metabolism KW - Animals KW - Base Sequence KW - Phosphorylation KW - Humans KW - Calcium-Calmodulin-Dependent Protein Kinases -- antagonists & inhibitors KW - Molecular Sequence Data KW - Enzyme Inhibitors -- pharmacology KW - Mice KW - Ionomycin -- pharmacology KW - Amino Acid Sequence KW - Cell Line KW - Calcium -- metabolism KW - Myosins -- metabolism KW - Threonine -- metabolism KW - Mast Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72368378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Calcium-dependent+threonine+phosphorylation+of+nonmuscle+myosin+in+stimulated+RBL-2H3+mast+cells.&rft.au=Buxton%2C+D+B%3BAdelstein%2C+R+S&rft.aulast=Buxton&rft.aufirst=D&rft.date=2000-11-03&rft.volume=275&rft.issue=44&rft.spage=34772&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-14 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cys-140 is critical for metabotropic glutamate receptor-1 dimerization. AN - 72367592; 10945991 AB - Metabotropic glutamate receptor 1 (mGluR1) expresses at the cell surface as disulfide-linked dimers and can be reduced to monomers with sulfhydryl reagents. To identify the dimerization domain, we transiently expressed in HEK-293 cells a truncated version of mGluR1 (RhodC-R1) devoid of the extracellular domain (ECD). RhodC-R1 was a monomer in the absence or presence of the reducing agents, suggesting that dimerization occurs via the ECD. To identify cysteine residues involved in dimerization within the ECD, cysteine to serine point mutations were made at three cysteines within the amino-terminal half of the ECD. A mutation at positions Cys-67, Cys-109, and Cys-140 all resulted in significant amounts of monomers in the absence of reducing agents. The monomeric C67S and C109S mutants were not properly glycosylated, failed to reach the cell surface, and showed no glutamate response, indicating that these mutant receptors were improperly folded and/or processed and thus retained intracellularly. In contrast, the monomeric C140S mutant was properly glycosylated, processed, and expressed at the cell surface. Phosphoinositide hydrolysis assay showed that the glutamate response of the C140S mutant receptor was similar to the wild type receptor. Substitution of a cysteine for Ser-129, Lys-134, Asp-143, and Thr-146 on the C140S mutant background restored receptor dimerization. Taken together, the results suggest that Cys-140 contributes to intermolecular disulfide-linked dimerization of mGluR1. JF - The Journal of biological chemistry AU - Ray, K AU - Hauschild, B C AD - Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. Kray@helix.nih.gov Y1 - 2000/11/03/ PY - 2000 DA - 2000 Nov 03 SP - 34245 EP - 34251 VL - 275 IS - 44 SN - 0021-9258, 0021-9258 KW - Receptors, Metabotropic Glutamate KW - 0 KW - Type C Phospholipases KW - EC 3.1.4.- KW - GTP-Binding Protein alpha Subunits, Gq-G11 KW - EC 3.6.5.1 KW - Heterotrimeric GTP-Binding Proteins KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Humans KW - Dimerization KW - Molecular Sequence Data KW - Heterotrimeric GTP-Binding Proteins -- metabolism KW - Amino Acid Sequence KW - Hydrolysis KW - Signal Transduction KW - Cell Line KW - Type C Phospholipases -- metabolism KW - Cysteine -- metabolism KW - Receptors, Metabotropic Glutamate -- chemistry KW - Receptors, Metabotropic Glutamate -- genetics KW - Receptors, Metabotropic Glutamate -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72367592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cys-140+is+critical+for+metabotropic+glutamate+receptor-1+dimerization.&rft.au=Ray%2C+K%3BHauschild%2C+B+C&rft.aulast=Ray&rft.aufirst=K&rft.date=2000-11-03&rft.volume=275&rft.issue=44&rft.spage=34245&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-14 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of turgor pressure on outer hair cell motility. AN - 85357872; pmid-11108370 AB - The motor in the outer hair cell converts electrical energy directly into mechanical energy. There are two possible mechanisms for such a motor: one depends on changes in the membrane area ("area motor") and the other on changes in the stiffness ("stiffness motor"). These two mechanisms, which are not mutually exclusive, give different predictions on turgor pressure dependence of the amplitude. It was found that an increased pressure shifts the voltage dependence but does not change the amplitude of length changes. This observation is incompatible with a pure stiffness motor model. It was also confirmed that length changes are closely related to charge movements by monitoring the membrane capacitance. It can be concluded that hair cell motility is primarily based on area changes, and not changes in the elastic moduli. JF - The Journal of the Acoustical Society of America AU - Adachi, M AU - Sugawara, M AU - Iwasa, K H AD - Biophysics Section, Laboratory of Cellular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892-0922, USA. Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 2299 EP - 2306 VL - 108 IS - 5 Pt 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine KW - Patch-Clamp Techniques -- methods KW - Animals KW - Guinea Pigs KW - Pressure KW - Models, Biological KW - Biomechanics KW - Cell Movement -- physiology KW - Hair Cells, Auditory, Outer -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85357872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Effect+of+turgor+pressure+on+outer+hair+cell+motility.&rft.au=Adachi%2C+M%3BSugawara%2C+M%3BIwasa%2C+K+H&rft.aulast=Adachi&rft.aufirst=M&rft.date=2000-11-01&rft.volume=108&rft.issue=5+Pt+1&rft.spage=2299&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Effects of adductor muscle stimulation on speech in abductor spasmodic dysphonia. AN - 85354127; pmid-11081615 AB - OBJECTIVE: To determine whether adductor laryngeal muscle stimulation might be a beneficial treatment alternative for abductor spasmodic dysphonia (ABSD). STUDY DESIGN: Baseline comparisons were made on measures of voiceless consonant and syllable duration between patients with ABSD and normal control subjects, and speech and voice production with and without muscle stimulation were compared within 10 patients with ABSD. METHODS: Baseline group comparisons were conducted on measures of syllable and voiceless consonant duration between the patients and the control subjects. Neuromuscular stimulation was applied to the thyroarytenoid or lateral cricoarytenoid muscles in the patients during extended phonation, and measures were made of fundamental frequency and sound pressure level in the stimulated and nonstimulated conditions. Voiceless consonant duration was compared with and without adductor laryngeal muscle stimulation during syllable repetitions and sentences in the patients. RESULTS: Before stimulation, the patients had increased syllable durations in comparison with control subjects (P = .003). Repeated within-patient comparisons with and without stimulation demonstrated significant (P < .008) reductions in voiceless consonant durations during syllable repetition. The more severely affected patients had the greatest reductions in voiceless consonant duration during sentence production. CONCLUSIONS: Adductor muscle stimulation improved speech production in patients with ABSD, and the improvement was greatest in the most severely affected patients. Therefore adductor muscle stimulation has potential for benefiting patients with ABSD. JF - The Laryngoscope AU - Bidus, K A AU - Thomas, G R AU - Ludlow, C L AD - Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1943 EP - 1949 VL - 110 IS - 11 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Vocal Cords -- physiology KW - Voice Disorders -- etiology KW - Humans KW - Adult KW - Laryngoscopy -- methods KW - Sound Spectrography KW - Aged KW - Middle Aged KW - Electric Stimulation KW - Female KW - Male KW - Voice Disorders -- therapy KW - Laryngeal Muscles -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85354127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Effects+of+adductor+muscle+stimulation+on+speech+in+abductor+spasmodic+dysphonia.&rft.au=Bidus%2C+K+A%3BThomas%2C+G+R%3BLudlow%2C+C+L&rft.aulast=Bidus&rft.aufirst=K&rft.date=2000-11-01&rft.volume=110&rft.issue=11&rft.spage=1943&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-04-12 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - A-ZIP/F-1 mice lacking white fat: a model for understanding lipoatrophic diabetes AN - 759313333; 13652742 AB - The A-ZIP/F-1 mouse is lacking virtually all white adipose tissue. Like humans with extensive deficiencies of adipose tissue, the A-ZIP/F-1 mice develop a severe form of insulin resistant diabetes. We have studied the physiology of the A-ZIP/F-1 mice. Their adaptation to fasting is notable for its rapidity and the use of torpor, a hibernation-like state, to minimize energy needs. Transplantation of adipose tissue reversed the metabolic manifestations in the mice, demonstrating that the lack of adipose tissue is the cause of the insulin resistance. Leptin replacement is not very effective in reversing the diabetes of the A-ZIP/F-1 mice, which contrasts with its efficacy in the aP2-SREBP-1c mouse. INTERNATIONAL JOURNAL OF OBESITY: (2000) 24, Suppl 4, S11-S14 JF - International Journal of Obesity AU - Reitman, M L AU - Gavrilova, O AD - Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - S11 EP - S14 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 24 IS - S4 SN - 0307-0565, 0307-0565 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759313333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=A-ZIP%2FF-1+mice+lacking+white+fat%3A+a+model+for+understanding+lipoatrophic+diabetes&rft.au=Reitman%2C+M+L%3BGavrilova%2C+O&rft.aulast=Reitman&rft.aufirst=M&rft.date=2000-11-01&rft.volume=24&rft.issue=S4&rft.spage=S11&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fsj.ijo.0801493 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1038/sj.ijo.0801493 ER - TY - JOUR T1 - [A "technically attainable" refernce value for exposure to wood dust in the light of Law 66/2000]. TT - Un "tecnicamente ottenibile" livello di riferimento per esposizione a polvere di legno dopo il D.lgs. 66/2000. AN - 72573372; 11233576 AB - The question of appropriate exposure standards for wood dust is addressed by reference to the major health effects, especially sino-nasal cancer, that have been investigated. A review of several key papers on wood dust exposure permits some associations to be made between exposure data and effects, particularly impaired/suppressed nasal mucociliary clearance, according to which it may be suggested, based on available evidence, that a standard of 1.5-2 mg/m3 of total suspended wood dust could reasonably protect against the observed effects. Moreover, data from the literature show that reducing personal wood dust exposures to below 2 mg/m3 is accomplished relatively easily, whereas reducing exposures to below 1 mg/m3 is considerably more difficult and expensive. The exposure level of 1.5-2 mg/m3 is suggested for all wood dusts; it does not seem reasonable at the present time to distinguish between hardwood and softwood because many of the important mortality studies report results based on patients with mixed exposures. The threshold exposure value of 5 mg/m3 for hardwood proposed from 1/1/2003 by Law 66/2000 is deemed to be too high as a health-based occupational exposure limit. JF - La Medicina del lavoro AU - Innocenti, A AD - U.O. Igiene e Salute nei Luoghi di Lavoro, USL 3 Pistoia, Regione Toscana, Villa Ankurj, via provinciale lucchese, 51010 Massa e Cozzile, PT. PY - 2000 SP - 565 EP - 574 VL - 91 IS - 6 SN - 0025-7818, 0025-7818 KW - Dust KW - 0 KW - Index Medicus KW - Humans KW - Italy KW - Threshold Limit Values KW - Wood KW - Occupational Exposure -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72573372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=La+Medicina+del+lavoro&rft.atitle=%5BA+%22technically+attainable%22+refernce+value+for+exposure+to+wood+dust+in+the+light+of+Law+66%2F2000%5D.&rft.au=Innocenti%2C+A&rft.aulast=Innocenti&rft.aufirst=A&rft.date=2000-11-01&rft.volume=91&rft.issue=6&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=La+Medicina+del+lavoro&rft.issn=00257818&rft_id=info:doi/ LA - Italian DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-03 N1 - Date created - 2001-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polycyclic aromatic hydrocarbons in placenta. AN - 72546738; 11211237 AB - Concentrations of chrysene, benz [a] anthracene, benzo [a]-pyrene, benzo [b] fluoranthene, indeno [1,2,3-c,d] pyrene, dibenz [a,h] anthracene, and benzo [g,h,i] perylene were measured in placentas from 200 women from two cities in Ukraine, Kyiv and Dniprodzerzhinsk. The participants had no special exposures and were chosen from among subjects in an ongoing study of reproductive health. All seven of the polycyclic aromatic hydrocarbons (PAHs) were found in all placentas, with the sole exception of benzo [a] pyrene in one placenta. Chrysene was present at the highest concentrations, with median 1.38 ng/g dry weight. Dibenz [a,h] anthracene and benzo [g,h,i] perylene had the lowest concentrations; each had median 0.73 ng/g dry weight. Concentrations in Kyiv were slightly higher than those in Dniprodzerzhinsk, but the difference was significant only for dibenz [a,h] anthracene. Dibenz [a,h] anthracene and benzo [g,h,i] perylene increased significantly with maternal body mass index, but other PAHs showed no such pattern. Placentas from deliveries in autumn or winter had slightly but not significantly higher concentrations. Concentrations were not related to maternal age. There were too few smokers in the sample for meaningful evaluation. No associations were seen between any of the placental PAH concentrations and birth weight of the infant. JF - Human & experimental toxicology AU - Gladen, B C AU - Zadorozhnaja, T D AU - Chislovska, N AU - Hryhorczuk, D O AU - Kennicutt, M C AU - Little, R E AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 597 EP - 603 VL - 19 IS - 11 SN - 0960-3271, 0960-3271 KW - Air Pollutants KW - 0 KW - Polycyclic Aromatic Hydrocarbons KW - Index Medicus KW - Humans KW - Ukraine KW - Adult KW - Infant, Newborn KW - Environmental Exposure KW - Birth Weight -- drug effects KW - Male KW - Female KW - Environmental Monitoring -- methods KW - Pregnancy KW - Placenta -- chemistry KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Polycyclic Aromatic Hydrocarbons -- adverse effects KW - Air Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72546738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+experimental+toxicology&rft.atitle=Polycyclic+aromatic+hydrocarbons+in+placenta.&rft.au=Gladen%2C+B+C%3BZadorozhnaja%2C+T+D%3BChislovska%2C+N%3BHryhorczuk%2C+D+O%3BKennicutt%2C+M+C%3BLittle%2C+R+E&rft.aulast=Gladen&rft.aufirst=B&rft.date=2000-11-01&rft.volume=19&rft.issue=11&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Human+%26+experimental+toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-22 N1 - Date created - 2001-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Solution structure of DinI provides insight into its mode of RecA inactivation. AN - 72522280; 11152126 AB - The Escherichia coli RecA protein triggers both DNA repair and mutagenesis in a process known as the SOS response. The 81-residue E. coli protein DinI inhibits activity of RecA in vivo. The solution structure of DinI has been determined by multidimensional triple resonance NMR spectroscopy, using restraints derived from two sets of residual dipolar couplings, obtained in bicelle and phage media, supplemented with J couplings and a moderate number of NOE restraints. DinI has an alpha/beta fold comprised of a three-stranded beta-sheet and two alpha-helices. The beta-sheet topology is unusual: the central strand is flanked by a parallel and an antiparallel strand and the sheet is remarkably flat. The structure of DinI shows that six negatively charged Glu and Asp residues on DinI's kinked C-terminal alpha-helix form an extended, negatively charged ridge. We propose that this ridge mimics the electrostatic character of the DNA phospodiester backbone, thereby enabling DinI to compete with single-stranded DNA for RecA binding. Biochemical data confirm that DinI is able to displace ssDNA from RecA. JF - Protein science : a publication of the Protein Society AU - Ramirez, B E AU - Voloshin, O N AU - Camerini-Otero, R D AU - Bax, A AD - Laboratory of Chemical Physics, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 2161 EP - 2169 VL - 9 IS - 11 SN - 0961-8368, 0961-8368 KW - Bacterial Proteins KW - 0 KW - DinI protein, E coli KW - Escherichia coli Proteins KW - Aspartic Acid KW - 30KYC7MIAI KW - Glutamic Acid KW - 3KX376GY7L KW - DNA KW - 9007-49-2 KW - Rec A Recombinases KW - EC 2.7.7.- KW - Index Medicus KW - Software KW - Protein Structure, Secondary KW - DNA Repair KW - Models, Molecular KW - DNA -- metabolism KW - Protein Folding KW - Glutamic Acid -- chemistry KW - Escherichia coli -- chemistry KW - Protein Structure, Tertiary KW - Protein Binding KW - Aspartic Acid -- chemistry KW - Protein Conformation KW - Mutagenesis KW - Magnetic Resonance Spectroscopy KW - Bacterial Proteins -- chemistry KW - Rec A Recombinases -- chemistry KW - Bacterial Proteins -- metabolism KW - Rec A Recombinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72522280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+science+%3A+a+publication+of+the+Protein+Society&rft.atitle=Solution+structure+of+DinI+provides+insight+into+its+mode+of+RecA+inactivation.&rft.au=Ramirez%2C+B+E%3BVoloshin%2C+O+N%3BCamerini-Otero%2C+R+D%3BBax%2C+A&rft.aulast=Ramirez&rft.aufirst=B&rft.date=2000-11-01&rft.volume=9&rft.issue=11&rft.spage=2161&rft.isbn=&rft.btitle=&rft.title=Protein+science+%3A+a+publication+of+the+Protein+Society&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-01-09 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 1F0A; PDB N1 - SuppNotes - Cited By: Science. 1999 Dec 17;286(5448):2349-52 [10600747] Prog Nucleic Acid Res Mol Biol. 1999;63:311-66 [10506835] J Mol Biol. 1987 Apr 5;194(3):531-44 [3041007] Proc Natl Acad Sci U S A. 1988 Mar;85(6):1806-10 [3126496] J Mol Biol. 1991 Feb 5;217(3):517-30 [1847217] Proteins. 1991;11(4):281-96 [1758883] Biochemistry. 1992 Sep 22;31(37):8898-905 [1390677] J Mol Biol. 1993 Sep 5;233(1):123-38 [8377180] J Biomol NMR. 1993 Jul;3(4):487-93 [8400833] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] Biochemistry. 1996 Jan 23;35(3):792-802 [8547259] J Mol Graph. 1996 Feb;14(1):51-5, 29-32 [8744573] Protein Sci. 1997 Jun;6(6):1248-63 [9194185] J Biomol NMR. 1997 Apr;9(3):329-35 [9229505] Nat Struct Biol. 1997 Sep;4(9):732-8 [9303001] Science. 1997 Nov 7;278(5340):1111-4 [9353189] J Magn Reson. 1997 Mar;125(1):171-7 [9245376] J Magn Reson. 1998 Apr;131(2):373-8 [9571116] EMBO J. 1998 Jun 1;17(11):3207-16 [9606202] J Magn Reson. 1998 Jul;133(1):216-21 [9654491] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10348-50 [9724704] Cell. 1998 Sep 4;94(5):573-83 [9741622] J Magn Reson. 1998 Nov;135(1):185-93 [9799693] J Biomol NMR. 1998 Oct;12(3):361-72 [9835045] Nat Struct Biol. 1998 Dec;5(12):1065-74 [9846877] J Magn Reson. 1998 Dec;135(2):541-6 [9878482] Biochemistry. 1999 Mar 16;38(11):3268-79 [10079069] Protein Sci. 1999 Apr;8(4):800-9 [10211826] J Biomol NMR. 1999 Mar;13(3):289-302 [10212987] J Mol Biol. 1986 Oct 5;191(3):523-51 [3029386] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Homology modeling and molecular dynamics simulations of lymphotactin. AN - 72520625; 11152129 AB - We have modeled the structure of human lymphotactin (hLpnt), by homology modeling and molecular dynamics simulations. This chemokine is unique in having a single disulfide bond and a long C-terminal tail. Because other structural classes of chemokines have two pairs of Cys residues, compared to one in Lpnt, and because it has been shown that both disulfide bonds are required for stability and function, the question arises how the Lpnt maintains its structural integrity. The initial structure of hLpnt was constructed by homology modeling. The first 63 residues in the monomer of hLpnt were modeled using the structure of the human CC chemokine, RANTES, whose sequence appeared most similar. The structure of the long C-terminal tail, missing in RANTES, was taken from the human muscle fatty-acid binding protein. In a Protein Data Bank search, this protein was found to contain a sequence that was most homologous to the long tail. Consequently, the modeled hLpnt C-terminal tail consisted of both alpha-helical and beta-motifs. The complete model of the hLpnt monomer consisted of two alpha-helices located above the five-stranded beta-sheet. Molecular dynamics simulations of the solvated initial model have indicated that the stability of the predicted fold is related to the geometry of Pro78. The five-stranded beta-sheet appeared to be preserved only when Pro78 was modeled in the cis conformation. Simulations were also performed both for the C-terminal truncated forms of the hLpnt that contained one or two (CC chemokine-like) disulfide bonds, and for the chicken Lpnt (cLpnt). Our MD simulations indicated that the turn region (T30-G34) in hLpnt is important for the interactions with the receptor, and that the long C-terminal region stabilizes both the turn (T30-G34) and the five-stranded beta-sheet. The major conclusion from our theoretical studies is that the lack of one disulfide bond and the extension of the C-terminus in hLptn are mutually complementary. It is very likely that removal of two Cys residues sufficiently destabilizes the structure of a chemokine molecule, particularly the core beta-sheet, to abolish its biological function. However, this situation is rectified by the long C-terminal segment. The role of this long region is most likely to stabilize the first beta-turn region and alpha-helix H1, explaining how this chemokine can function with a single disulfide bond. JF - Protein science : a publication of the Protein Society AU - Buyong AU - Xiong, J AU - Lubkowski, J AU - Nussinov, R AD - Laboratory of Experimental and Computational Biology, NCI-FCRDC, Frederick, Maryland 21702, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 2192 EP - 2199 VL - 9 IS - 11 SN - 0961-8368, 0961-8368 KW - Carrier Proteins KW - 0 KW - Chemokine CCL5 KW - Chemokines, C KW - Disulfides KW - FABP7 protein, human KW - Fatty Acid-Binding Protein 7 KW - Fatty Acid-Binding Proteins KW - Lymphokines KW - Neoplasm Proteins KW - Sialoglycoproteins KW - Tumor Suppressor Proteins KW - XCL1 protein, human KW - Xcl1 protein, mouse KW - lymphotactin KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Software KW - Animals KW - Protein Structure, Secondary KW - Carrier Proteins -- chemistry KW - Humans KW - Amino Acid Sequence KW - Mutagenesis KW - Chickens KW - Cysteine -- chemistry KW - Protein Folding KW - Molecular Sequence Data KW - Databases, Factual KW - Models, Chemical KW - Chemokine CCL5 -- chemistry KW - Sequence Homology, Amino Acid KW - Protein Conformation KW - Models, Theoretical KW - Lymphokines -- metabolism KW - Lymphokines -- chemistry KW - Sialoglycoproteins -- metabolism KW - Sialoglycoproteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72520625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+science+%3A+a+publication+of+the+Protein+Society&rft.atitle=Homology+modeling+and+molecular+dynamics+simulations+of+lymphotactin.&rft.au=Buyong%3BXiong%2C+J%3BLubkowski%2C+J%3BNussinov%2C+R&rft.aulast=Buyong&rft.aufirst=&rft.date=2000-11-01&rft.volume=9&rft.issue=11&rft.spage=2192&rft.isbn=&rft.btitle=&rft.title=Protein+science+%3A+a+publication+of+the+Protein+Society&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-26 N1 - Date created - 2001-01-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1991 Sep 13;253(5025):1280-3 [1891716] Biochemistry. 1999 May 11;38(19):5995-6002 [10320325] J Biol Chem. 1991 Dec 5;266(34):23128-34 [1744111] Nature. 1994 Feb 17;367(6464):660-3 [8107853] Science. 1994 Mar 25;263(5154):1762-7 [8134838] Science. 1994 Apr 1;264(5155):90-2 [8140420] J Biol Chem. 1994 Jun 10;269(23):16075-81 [8206907] Biochemistry. 1994 Jul 12;33(27):8361-6 [8031770] J Biol Chem. 1995 Mar 31;270(13):7077-87 [7706245] J Leukoc Biol. 1995 May;57(5):703-11 [7759949] J Biol Chem. 1996 Apr 19;271(16):9579-86 [8621632] Biochemistry. 1996 May 28;35(21):6569-84 [8639605] J Biol Chem. 1996 Jun 14;271(24):14344-52 [8662882] FEBS Lett. 1996 Oct 21;395(2-3):277-82 [8898111] Nat Struct Biol. 1997 Jan;4(1):64-9 [8989326] J Biol Chem. 1997 Jan 17;272(3):1725-9 [8999852] Protein Sci. 1997 Mar;6(3):598-608 [9070442] Biochemistry. 1997 Apr 15;36(15):4412-22 [9109648] Proteins. 1997 Apr;27(4):556-66 [9141135] J Biol Chem. 1997 Aug 1;272(31):19518-24 [9235955] Blood. 1997 Aug 1;90(3):909-28 [9242519] Biochemistry. 1997 Aug 12;36(32):9642-8 [9289016] J Immunol. 1997 Sep 15;159(6):2554-8 [9300671] Methods Enzymol. 1997;287:206-15 [9330324] J Biol Chem. 1998 Mar 20;273(12):7118-22 [9507024] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6941-6 [9618518] J Biol Chem. 1998 Aug 28;273(35):22471-9 [9712872] J Leukoc Biol. 1999 Jan;65(1):87-93 [9886250] Chem Biol. 1999 Jan;6(1):43-51 [9889151] Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9074-6 [10430897] J Mol Biol. 1999 Oct 22;293(2):321-31 [10550212] J Mol Biol. 2000 Mar 3;296(4):1091-104 [10686106] Biochemistry. 1989 Nov 28;28(24):9469-78 [2611243] Biochemistry. 1990 Feb 20;29(7):1689-96 [2184886] Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):502-6 [1988949] Science. 1991 Sep 13;253(5025):1278-80 [1840701] Biochemistry. 1999 Feb 2;38(5):1402-14 [9931005] Structure. 1999 Feb 15;7(2):157-68 [10368283] J Biol Chem. 1991 Oct 5;266(28):18989-94 [1918013] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - SM22alpha promoter targets gene expression to vascular smooth muscle cells in vitro and in vivo. AN - 72517959; 11147575 AB - Gene transfer into vascular smooth muscle cells (vsmcs) holds promise for studying the pathogenesis of arterial disorders. However, a potential limitation of vectors with heterologous promoters is organ toxicity resulting from unrestricted transgene expression. Vascular smooth muscle cell-specific gene expression could increase the safety of vectors for vascular diseases. To develop vectors that target gene expression to vsmcs, we constructed vectors encoding human placental alkaline phosphatase (hpAP) and chloramphenicol transferase (CAT) driven by a 441-bp region of the murine SM22alpha promoter (AdSM22alpha-hpAP). Transfection of AdSM22alpha-hpAP into vascular and nonvascular cells resulted in the expression of alkaline phosphatase (AP) in primary arterial and venous smcs, but not in primary endothelial cells or National Institutes of Health (NIH) 3T3 cells. Expression of AP was observed on 32.5 +/- 1.4% of primary pig vsmcs-infected AdSM22alpha-hpAP at a multiplicity of infection (MOI) of 500; whereas, infection with AdCMV-hpAP resulted in 100 +/- 0.0% expression at a MOI of 250. In vitro, expression from the heterologous cytomegalovirus (CMV) promoter was approximately 10(3)-fold higher in vsmcs, compared with the SM22alpha promoter. Following introduction of AdSM22alpha-hpAP vectors into balloon-injured pig arteries, AP recombinant protein was detected in neointimal (2.23 +/- 1.14%) and medial (0.56 +/- 0.21%) smcs, but not in endothelial or adventitial cells. In contrast, AdCMV-hpAP vectors led to AP expression in intimal endothelial and smcs cells (39.14 +/- 10.09%) and medial smcs (2.84 +/- 1.05%). AP expression was not observed in endothelial or vsmcs following transfection with the control vector, adenoviral vector lacking E1 (AddeltaE1). The SM22alpha promoter programs recombinant gene expression exclusively to vascular smcs in vitro and in vivo. Although expression levels are lower than with heterologous promoters, these vectors may provide a safe and effective tool for gene therapy of vascular diseases. JF - Molecular medicine (Cambridge, Mass.) AU - Akyürek, L M AU - Yang, Z Y AU - Aoki, K AU - San, H AU - Nabel, G J AU - Parmacek, M S AU - Nabel, E G AD - Vascular Biology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 983 EP - 991 VL - 6 IS - 11 SN - 1076-1551, 1076-1551 KW - Microfilament Proteins KW - 0 KW - Muscle Proteins KW - Tagln protein, mouse KW - transgelin KW - Index Medicus KW - Animals KW - Mice KW - Muscle Proteins -- genetics KW - Promoter Regions, Genetic KW - Microfilament Proteins -- genetics KW - Muscle, Smooth, Vascular -- metabolism KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72517959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+medicine+%28Cambridge%2C+Mass.%29&rft.atitle=SM22alpha+promoter+targets+gene+expression+to+vascular+smooth+muscle+cells+in+vitro+and+in+vivo.&rft.au=Aky%C3%BCrek%2C+L+M%3BYang%2C+Z+Y%3BAoki%2C+K%3BSan%2C+H%3BNabel%2C+G+J%3BParmacek%2C+M+S%3BNabel%2C+E+G&rft.aulast=Aky%C3%BCrek&rft.aufirst=L&rft.date=2000-11-01&rft.volume=6&rft.issue=11&rft.spage=983&rft.isbn=&rft.btitle=&rft.title=Molecular+medicine+%28Cambridge%2C+Mass.%29&rft.issn=10761551&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-22 N1 - Date created - 2001-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines. AN - 72513206; 11194457 AB - Most breast cancer cell lines are resistant to TNF-related apoptosis inducing ligand (TRAIL) induced apoptosis. In sensitive breast cancer cell lines TRAIL rapidly induces the cleavage and activation of caspases leading to the subsequent cleavage of downstream caspase substrates. In contrast, there is no caspase activation in the resistant cell lines. The transcription factor NF-KB can inhibit apoptosis induced by a variety of stimuli including activation of death receptors. We investigated whether NF-kappaB contributes to the resistance of breast cancer cells to TRAIL induced apoptosis. All of the resistant breast cancer cell lines expressed NF-kappaB and had detectable NF-kappaB activity in nuclear extracts prior to treatment with TRAIL. Upon TRAIL treatment, a significant increase in NF-kappaB activity was seen in most of the cell lines. To directly test if NF-kappaB activity contributes to the resistance of these cell lines to TRAIL, we transiently transfected the resistant cell lines with an inhibitor of NF-kappaB (IkappaBdeltaN) and measured TRAIL induced apoptosis in control and transfected cells. All of the resistant cell lines tested showed an increase in TRAIL induced apoptosis when transfected with the IKBdeltaN. These results demonstrate that TRAIL resistant breast cancer cells fail to rapidly activate the apoptotic machinery but they do activate NF-kappaB. Inhibition of NF-kappaB activity increases the sensitivity to TRAIL mediated apoptosis in resistant cells. These results suggest that agents which inhibit NF-kappaB should increase the clinical efficacy of TRAIL in breast cancer cells. JF - Breast cancer research and treatment AU - Keane, M M AU - Rubinstein, Y AU - Cuello, M AU - Ettenberg, S A AU - Banerjee, P AU - Nau, M M AU - Lipkowitz, S AD - Genetics Department, Medicine Branch, National Cancer Institute, Bethesda 20889, MD, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 211 EP - 219 VL - 64 IS - 2 SN - 0167-6806, 0167-6806 KW - Apoptosis Regulatory Proteins KW - 0 KW - Membrane Glycoproteins KW - NF-kappa B KW - TNF-Related Apoptosis-Inducing Ligand KW - TNFSF10 protein, human KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Drug Interactions KW - Apoptosis KW - Tumor Cells, Cultured -- drug effects KW - Transfection KW - Humans KW - Female KW - Breast Neoplasms -- pathology KW - Tumor Necrosis Factor-alpha -- pharmacology KW - NF-kappa B -- pharmacology KW - Membrane Glycoproteins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72513206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Inhibition+of+NF-kappaB+activity+enhances+TRAIL+mediated+apoptosis+in+breast+cancer+cell+lines.&rft.au=Keane%2C+M+M%3BRubinstein%2C+Y%3BCuello%2C+M%3BEttenberg%2C+S+A%3BBanerjee%2C+P%3BNau%2C+M+M%3BLipkowitz%2C+S&rft.aulast=Keane&rft.aufirst=M&rft.date=2000-11-01&rft.volume=64&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-08 N1 - Date created - 2001-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - State-of-the-art methodologies in alcohol-related health services research. AN - 72511593; 11132358 AB - Many of the failures to replicate clinical findings of treatment efficacy in more realistic field and community settings can be attributed to inappropriate research designs and other methodological shortcomings. In order to increase research designers' awareness of existing methodologies that may be better suited to answer the critical questions inherent in health services research on alcohol-related issues, the National Institute on Alcohol Abuse and Alcoholism (NIAAA) convened an expert conference with three specific goals; (1) to identify the critical issues involved in alcohol services research; (2) to develop a primer that explicated each key area; and (3) to compile the resulting primers into an accessible resource for researchers, policy makers and consumers. The 9 papers in this special supplement are the product of that conference and are organized broadly around three phases of the research process: study design and implementation, data collection and use, and the analysis and interpretation of data. A final summary paper discusses the issues and offers a synthesis of key themes as well as some direction for the future. JF - Addiction (Abingdon, England) AU - Perl, H I AU - Dennis, M L AU - Huebner, R B AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 6000 Executive Blvd., MSC 7003, Suite 505, Bethesda, MD 20892-7003, USA. perl@nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - S275 EP - S280 VL - 95 Suppl 3 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - United States KW - Humans KW - Research Design KW - Health Services Research -- methods KW - Alcoholism -- therapy KW - Consensus Development Conferences, NIH as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72511593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=State-of-the-art+methodologies+in+alcohol-related+health+services+research.&rft.au=Perl%2C+H+I%3BDennis%2C+M+L%3BHuebner%2C+R+B&rft.aulast=Perl&rft.aufirst=H&rft.date=2000-11-01&rft.volume=95+Suppl+3&rft.issue=&rft.spage=S275&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-01 N1 - Date created - 2000-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessing environmental exposure in children: immunotoxicology screening. AN - 72508412; 11138669 AB - Environmental exposure to a number of xenobiotics, including pesticides, can have serious effects on the immune system of children, thus rendering them susceptible to infections or other disease states. To study this problem, a recycling chromatographic system for assessing cytokine profiles in humans has been developed and used for the measurement of immune system function in children with documented exposure to residential pesticides. The system is capable of measuring 30 different analytes in a single sample thus enabling the same time examination of representative markers of immune differentiation and function. In the present study, a cohort of 25 exposed children were examined and shown to exhibit a number of features; all subjects demonstrated some abnormalities in cytokines associated with hematopoiesis. Additionally, elevations in pro-inflammatory cytokines and neuropeptides indicated a state of generalized and neurogenic inflammation. Further analysis indicated that a depression of the cellular arm of the immune system that correlated with clinical indicators of lowered host resistance to infection could also be detected in a subgroup of the exposed subjects. All exposed children demonstrated evidence of hyperstimulation of the humoral immune system as indicated by elevated IL-5 concentrations and clinical allergy. The degree of immune dysregulation in the exposed children was found to be quite marked when compared to similar studies performed on age-matched controls. JF - Journal of exposure analysis and environmental epidemiology AU - Phillips, T M AD - Immunochemistry Laboratory, The George Washington University Medical Center, Washington, Distric of Columbia, USA. phillipt@ors.od.nih.gov PY - 2000 SP - 769 EP - 775 VL - 10 IS - 6 Pt 2 SN - 1053-4245, 1053-4245 KW - Biomarkers KW - 0 KW - Cytokines KW - Interleukin-5 KW - Pesticide Residues KW - Xenobiotics KW - Index Medicus KW - Cytokines -- analysis KW - Humans KW - Biomarkers -- analysis KW - Hypersensitivity -- etiology KW - Cohort Studies KW - Child KW - Child Welfare KW - Male KW - Female KW - Interleukin-5 -- analysis KW - Inflammation KW - Child, Preschool KW - Pesticide Residues -- immunology KW - Pesticide Residues -- adverse effects KW - Immune System -- drug effects KW - Xenobiotics -- immunology KW - Environmental Exposure -- analysis KW - Xenobiotics -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72508412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+analysis+and+environmental+epidemiology&rft.atitle=Assessing+environmental+exposure+in+children%3A+immunotoxicology+screening.&rft.au=Phillips%2C+T+M&rft.aulast=Phillips&rft.aufirst=T&rft.date=2000-11-01&rft.volume=10&rft.issue=6+Pt+2&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+analysis+and+environmental+epidemiology&rft.issn=10534245&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metaphors and models of executive functioning: comment on Giancola (2000). AN - 72506716; 11127434 AB - Clinical researchers have become increasingly interested in considering the role of normal and impaired executive functioning in psychopathology. The concept of executive functions is, however, often used as a metaphor for a wide range of operations that may, on the one hand, be distinct from one another, but also may be integrated in various ways under different information-processing conditions. A clinician's perspective of executive functioning should take full advantage of the rich body of data and theory that has developed in contemporary cognitive neuroscience around functions such as forms of inhibition and controlled (in contrast to automatic) functions, in a variety of cognitive domains such as making decisions and tracking performance. JF - Experimental and clinical psychopharmacology AU - Weingartner, H AD - Division of Basic Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA. herbw@nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 609 EP - 11; discussion 612-7 VL - 8 IS - 4 SN - 1064-1297, 1064-1297 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Aggression -- drug effects KW - Models, Psychological KW - Cognition -- drug effects KW - Ethanol -- pharmacology KW - Humans KW - Research Design KW - Metaphor KW - Alcohol-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72506716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Metaphors+and+models+of+executive+functioning%3A+comment+on+Giancola+%282000%29.&rft.au=Weingartner%2C+H&rft.aulast=Weingartner&rft.aufirst=H&rft.date=2000-11-01&rft.volume=8&rft.issue=4&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Exp Clin Psychopharmacol. 2000 Nov;8(4):576-97 [11127429] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDT) in relation to bone mineral density and rate of bone loss in menopausal women. AN - 72506581; 11128875 AB - The organochlorine pesticide 2,2-bis(p-chlorophenyl)-1,1,1,-trichloroethane (DDT) and its metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) are examples of an environmental contaminant that may have hormonal properties. Bone metabolism is both estrogen- and androgen-dependent. Exposures to various environmental endocrine disrupters can affect bone metabolism in animals, but there are no published data concerning the effect of DDE exposure on bone metabolism in humans. We hypothesized that high levels of DDE would be associated with lower bone density in peri- and postmenopausal women than in premenopausal women. Study subjects were drawn from the cohort of women who had participated in the Mount Sinai Medical Center Longitudinal Normative Bone Density Study (1984-1987). We used serum samples obtained at study entry to measure DDE levels in 103 (50 black, 53 white) women (mean age = 54.5 y [standard deviation = 5 y]). Measurements of bone mineral density at the lumbar spine and radius were made at 6-mo intervals during a 2-y period. DDE concentrations were significantly (p < .001) higher in blacks (13.9 ng/ml) than in whites (8.4 ng/ml), but there was no correlation between DDE concentration and bone density at the spine (mean levels = 1.065 g/cm2 and 1.043 g/cm2 in the lowest and highest quartiles, respectively, of DDE [trend p value = .85]) or at the radius (mean levels = 0.658 g/cm and 0.664 g/cm in the lowest and highest quartiles, respectively, of DDE [trend p value = .34]). Longitudinal analyses revealed no correlation between DDE and the rate of bone loss at either bone site. Similar results were seen in race-stratified analyses, as well as in analyses in which we controlled for lactation history and other potential confounders. We found little evidence that chronic low-level DDT exposure is associated with bone density in peri- and postmenopausal women. JF - Archives of environmental health AU - Bohannon, A D AU - Cooper, G S AU - Wolff, M S AU - Meier, D E AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. PY - 2000 SP - 386 EP - 391 VL - 55 IS - 6 SN - 0003-9896, 0003-9896 KW - Environmental Pollutants KW - 0 KW - DDT KW - CIW5S16655 KW - Abridged Index Medicus KW - Index Medicus KW - Probability KW - Humans KW - European Continental Ancestry Group KW - Linear Models KW - Cohort Studies KW - Absorptiometry, Photon KW - Middle Aged KW - Longitudinal Studies KW - African Continental Ancestry Group KW - Menopause KW - Female KW - Bone Density -- drug effects KW - Osteoporosis, Postmenopausal -- ethnology KW - Osteoporosis, Postmenopausal -- chemically induced KW - Osteoporosis, Postmenopausal -- diagnosis KW - DDT -- blood KW - DDT -- adverse effects KW - Environmental Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72506581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+environmental+health&rft.atitle=Exposure+to+1%2C1-dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDT%29+in+relation+to+bone+mineral+density+and+rate+of+bone+loss+in+menopausal+women.&rft.au=Bohannon%2C+A+D%3BCooper%2C+G+S%3BWolff%2C+M+S%3BMeier%2C+D+E&rft.aulast=Bohannon&rft.aufirst=A&rft.date=2000-11-01&rft.volume=55&rft.issue=6&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Archives+of+environmental+health&rft.issn=00039896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Using cytochrome P-450 gene knock-out mice to study chemical metabolism, toxicity, and carcinogenicity. AN - 72506006; 11127301 AB - Cytochrome P-450 (CYP) enzymes are heme-containing proteins that carry out oxidative metabolism of a wide range of structurally diverse exogenous chemicals and therapeutic agents as well as endogenous compounds. For some of these xenobiotics, oxidative metabolism results in the formation of toxic, mutagenic, or carcinogenic metabolites. In the past, the role of CYP enzymes in metabolism and chemical-induced toxicity was studied indirectly through use of specific antibodies or inducers and inhibitors of these enzymes. Progress in molecular biology and the ability to bioengineer animal models that do not express CYP1A2, CYP1A1, CYP1B1, CYP2E1, or both CYP1A2 and CYP2E1 isozymes has allowed for direct investigations of the in vivo role of these enzymes in the metabolism, toxicity, and carcinogenicity of xenobiotics. This article reviews research conducted to date that utilizes these genetically bioengineered mice in metabolism, toxicity, or carcinogenicity studies of chemicals. Some studies showed a positive correlation between in vivo results and in vitro predictions for the role of a specific CYP in chemical-induced effects, whereas other studies did not support in vitro predictions. Work reviewed herein demonstrates the importance of using animal models for investigating the role of specific CYP enzymes in metabolism and chemical-induced toxicity or carcinogenicity rather than relying solely on in vitro techniques. Eventually, studies of this nature will facilitate a more accurate assessment of human risks with regard to chemicals by helping us to understand the relationships between chemical metabolism, carcinogenicity, and polymorphisms in CYP enzymes. JF - Toxicologic pathology AU - Ghanayem, B I AU - Wang, H AU - Sumner, S AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Ghanayem@niehs.nih.gov PY - 2000 SP - 839 EP - 850 VL - 28 IS - 6 SN - 0192-6233, 0192-6233 KW - Carcinogens KW - 0 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cyp1b1 protein, mouse KW - Cytochrome P-450 CYP1B1 KW - Index Medicus KW - Animals KW - Carcinogenicity Tests -- methods KW - Disease Models, Animal KW - Mice KW - Metabolism KW - Carcinogens -- metabolism KW - Carcinogens -- toxicity KW - Cytochrome P-450 CYP2E1 -- physiology KW - Mice, Knockout UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72506006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Using+cytochrome+P-450+gene+knock-out+mice+to+study+chemical+metabolism%2C+toxicity%2C+and+carcinogenicity.&rft.au=Ghanayem%2C+B+I%3BWang%2C+H%3BSumner%2C+S&rft.aulast=Ghanayem&rft.aufirst=B&rft.date=2000-11-01&rft.volume=28&rft.issue=6&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-02-08 N1 - Date created - 2000-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of chemotherapy for AIDS-related malignancies in pediatric HIV disease. AN - 72505552; 11131726 JF - Annals of the New York Academy of Sciences AU - Gonzalez, C E AU - Adde, M AU - Taylor, P AU - Wood, L V AU - Magrath, I AD - HIV/AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. cgonzalez@cnmc.org Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 362 EP - 366 VL - 918 SN - 0077-8923, 0077-8923 KW - RNA, Viral KW - 0 KW - Index Medicus KW - Virus Replication -- drug effects KW - HIV-1 -- isolation & purification KW - Humans KW - Child KW - HIV-1 -- physiology KW - CD4 Lymphocyte Count KW - HIV-1 -- drug effects KW - RNA, Viral -- blood KW - Neoplasms -- drug therapy KW - Acquired Immunodeficiency Syndrome -- complications KW - HIV Infections -- complications KW - HIV Infections -- immunology KW - Acquired Immunodeficiency Syndrome -- immunology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72505552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Impact+of+chemotherapy+for+AIDS-related+malignancies+in+pediatric+HIV+disease.&rft.au=Gonzalez%2C+C+E%3BAdde%2C+M%3BTaylor%2C+P%3BWood%2C+L+V%3BMagrath%2C+I&rft.aulast=Gonzalez&rft.aufirst=C&rft.date=2000-11-01&rft.volume=918&rft.issue=&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incorporation of zidovudine into cord blood DNA of infants and peripheral blood DNA of their HIV-1-positive mothers. AN - 72505498; 11131712 AB - The nucleoside analogue 3'-azido-3'-deoxythymidine (AZT) is a weak carcinogen in adult female mice and a moderately strong carcinogen in the offspring of female mice given the drug during gestation. In addition, incorporation of AZT into DNA was observed in multiple organs of transplacentally exposed newborn mice. Here we investigate the incorporation of AZT into peripheral leukocyte DNA of HIV-1-positive adult pregnant women given AZT for variable times during gestation and cord blood of infants exposed to AZT in utero. The length of treatment varied between 10 days and 9 months. High molecular weight DNA was extracted from maternal peripheral blood mononuclear cells (PBMC) and infant cord blood. A specific AZT-DNA radioimmunoassay was used to determine the amount of AZT incorporated into leukocyte DNA. Incorporation of AZT into DNA ranged up to 183.3 and 344.5 molecules of AZT/10(6) nucleotides in the mothers and infants, respectively, and was detected in about 70% of samples. Therefore, AZT-induced mutagenic events are possible in the majority of adults and infants. No correlation was found between level of incorporation and length of AZT treatment, suggesting that the differences observed among the individuals arise from variability in AZT metabolism. These data support previous observations that a high degree of inter-individual variability in AZT phosphorylation occurs in primates. JF - Annals of the New York Academy of Sciences AU - Olivero, O A AU - Shearer, G M AU - Chougnet, C A AU - Kovacs, A A AU - Baker, R AU - Stek, A M AU - Khoury, M M AU - Poirier, M C AD - Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 37 Convent Drive MSC 4255, Bethesda, Maryland 20892-4255, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 262 EP - 268 VL - 918 SN - 0077-8923, 0077-8923 KW - Anti-HIV Agents KW - 0 KW - Zidovudine KW - 4B9XT59T7S KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Leukocytes -- metabolism KW - Infectious Disease Transmission, Vertical -- prevention & control KW - Animals KW - Humans KW - Adult KW - Infant, Newborn KW - Mice KW - HIV-1 KW - Female KW - Pregnancy KW - Zidovudine -- therapeutic use KW - Anti-HIV Agents -- pharmacokinetics KW - Fetal Blood -- chemistry KW - HIV Infections -- transmission KW - Pregnancy Complications, Infectious -- drug therapy KW - HIV Seropositivity -- drug therapy KW - Maternal-Fetal Exchange KW - Zidovudine -- pharmacokinetics KW - Anti-HIV Agents -- therapeutic use KW - DNA -- blood KW - HIV Infections -- drug therapy KW - HIV Infections -- prevention & control KW - Zidovudine -- blood KW - Anti-HIV Agents -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72505498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Incorporation+of+zidovudine+into+cord+blood+DNA+of+infants+and+peripheral+blood+DNA+of+their+HIV-1-positive+mothers.&rft.au=Olivero%2C+O+A%3BShearer%2C+G+M%3BChougnet%2C+C+A%3BKovacs%2C+A+A%3BBaker%2C+R%3BStek%2C+A+M%3BKhoury%2C+M+M%3BPoirier%2C+M+C&rft.aulast=Olivero&rft.aufirst=O&rft.date=2000-11-01&rft.volume=918&rft.issue=&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposure. AN - 72501809; 11131713 AB - Mitochondrial toxicity was examined in near-term fetuses of pregnant Erythrocebus patas monkeys given human equivalent doses of 3'-azido-3'deoxythymidine (AZT) during the second half of gestation. Pregnant monkeys were dosed daily with 10 or 40 mg AZT, equivalent to about 21% and 86% of the daily AZT dose (500 mg) given to HIV-1-positive pregnant women to prevent maternal-fetal virus transmission. The fetal tissues examined include heart and skeletal muscle, which have high energy requirements, and placenta, which is less dependent on mitochondrial integrity. Slot blot quantitation of mitochondrial DNA (mtDNA) levels showed dose-dependent depletion in heart, skeletal muscle, and placenta from AZT-exposed fetuses compared to unexposed controls. Furthermore, mtDNA degradation, observed by Southern blot analysis, appeared more extensive in AZT-exposed tissues compared to unexposed controls. Mitochondrial functional integrity, as determined by oxidative phosphorylation (OXPHOS) enzyme assays, was also examined in heart, skeletal muscle, and placenta. All three tissues showed strong dose-related decreases in Complex I. In placenta, dose-related increases for Complexes II and IV and a decrease for Complex III were observed. Dose-related increases for Complexes II and IV observed in heart and skeletal muscle have been reported. The increase in Complex IV (cytochrome c oxidase) activity in heart and skeletal muscle tissue from patas fetuses exposed to 40 mg AZT/day has been confirmed here by histochemical staining. Overall, data demonstrate that mitochondrial toxicity, evidenced by depletion in mtDNA and OXPHOS enzyme abnormalities, is manifested similarly in heart, skeletal muscle, and placenta of AZT-exposed monkey fetuses. It is therefore possible that the placenta, which is a readily accessible tissue, might be an indicator of potential mitochondrial toxicity in human pregnancies involving nucleoside analog drug exposure. JF - Annals of the New York Academy of Sciences AU - Gerschenson, M AU - Poirier, M C AD - Division of Basic Sciences, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892-4255, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 269 EP - 281 VL - 918 SN - 0077-8923, 0077-8923 KW - Anti-HIV Agents KW - 0 KW - DNA, Mitochondrial KW - Zidovudine KW - 4B9XT59T7S KW - Electron Transport Complex IV KW - EC 1.9.3.1 KW - Index Medicus KW - Animals KW - Mitochondria, Muscle -- metabolism KW - Humans KW - Placenta -- drug effects KW - Mitochondria, Muscle -- drug effects KW - Pregnancy KW - Muscle, Skeletal -- embryology KW - DNA, Mitochondrial -- drug effects KW - Placenta -- pathology KW - Mitochondria, Heart -- drug effects KW - Erythrocebus patas KW - Heart -- embryology KW - Mitochondria, Heart -- metabolism KW - Electron Transport Complex IV -- metabolism KW - Female KW - Male KW - DNA, Mitochondrial -- genetics KW - Anti-HIV Agents -- toxicity KW - Maternal-Fetal Exchange KW - Zidovudine -- toxicity KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72501809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Fetal+patas+monkeys+sustain+mitochondrial+toxicity+as+a+result+of+in+utero+zidovudine+exposure.&rft.au=Gerschenson%2C+M%3BPoirier%2C+M+C&rft.aulast=Gerschenson&rft.aufirst=M&rft.date=2000-11-01&rft.volume=918&rft.issue=&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The National Institute of Environmental Health Sciences' research program on children's environmental health. AN - 72499396; 11138655 AB - This article highlights the wide array of research programs supported by the National Institute of Environmental Health Sciences (NIEHS) that address issues related to children's environmental health. Special attention is given to the interagency, collaborative Centers for Children's Environmental Health and Disease Prevention Research program. A brief description of each of the eight centers highlights scientific foci and research efforts to date. In addition to discussing NIEHS-supported research programs, the article emphasizes the NIEHS' commitment to the promotion of translating basic research findings into public health knowledge so that culturally sensitive and applicable interventions may be developed. JF - Journal of exposure analysis and environmental epidemiology AU - O'Fallon, L R AU - Collman, G W AU - Dearry, A AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. PY - 2000 SP - 630 EP - 637 VL - 10 IS - 6 Pt 2 SN - 1053-4245, 1053-4245 KW - Index Medicus KW - Public Health KW - Interinstitutional Relations KW - Humans KW - Health Knowledge, Attitudes, Practice KW - Child KW - Research -- trends KW - Research Support as Topic KW - Environmental Health KW - Environmental Exposure KW - Child Welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72499396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+analysis+and+environmental+epidemiology&rft.atitle=The+National+Institute+of+Environmental+Health+Sciences%27+research+program+on+children%27s+environmental+health.&rft.au=O%27Fallon%2C+L+R%3BCollman%2C+G+W%3BDearry%2C+A&rft.aulast=O%27Fallon&rft.aufirst=L&rft.date=2000-11-01&rft.volume=10&rft.issue=6+Pt+2&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+analysis+and+environmental+epidemiology&rft.issn=10534245&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Somatic alterations of the androgen receptor CAG repeat in human colon cancer delineate a novel mutation pathway independent of microsatellite instability. AN - 72482533; 11120331 AB - The human androgen receptor gene contains a polymorphic CAG repeat region ranging from 8 to about 35 repeats in the normal human population. The repeat length is inversely related to the transactivation potential of the receptor. We have analyzed the repeat length in 50 sporadic colon cancer samples in comparison to surrounding healthy mucosa and have found somatic reductions of up to 10 repeats in 5 cases (10%), 3 of which were complex, probably involving both alleles. Alterations occurred in tumors with and without microsatellite instability indicating that they follow an independent mutation pathway. The similar repeat of the huntingtin gene did not show any somatic alterations in the same cases. No correlation to sex, tumor stage, location, or histology was evident. In the tumors that showed somatic reductions, the reduced allele was present in at least half of the cells and thus in most, if not all, of the tumor component of the sample. Somatic reductions of the androgen receptor CAG repeat thus occur frequently, through a pathway distinct from microsatellite instability and early during colon carcinogenesis. The receptor is expressed in most normal and neoplastic tissue samples analyzed. Apparent growth selection of cells bearing shortened AR alleles suggests that androgens contribute to colon carcinogenesis in a yet unknown way. JF - Cancer genetics and cytogenetics AU - Ferro, P AU - Catalano, M G AU - Raineri, M AU - Reato, G AU - dell'Eva, R AU - Risio, M AU - Foà, R AU - Fortunati, N AU - Pfeffer, U AD - Laboratory of Molecular Biology, National Cancer Institute, Genoa, Genoa, Italy. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 35 EP - 40 VL - 123 IS - 1 SN - 0165-4608, 0165-4608 KW - DNA, Neoplasm KW - 0 KW - Receptors, Androgen KW - Index Medicus KW - DNA, Neoplasm -- chemistry KW - Alleles KW - Gene Frequency KW - Humans KW - DNA Mutational Analysis KW - DNA, Neoplasm -- genetics KW - Mutation KW - Male KW - Female KW - Microsatellite Repeats -- genetics KW - Colonic Neoplasms -- genetics KW - Receptors, Androgen -- genetics KW - Trinucleotide Repeats -- genetics KW - Colonic Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72482533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+genetics+and+cytogenetics&rft.atitle=Somatic+alterations+of+the+androgen+receptor+CAG+repeat+in+human+colon+cancer+delineate+a+novel+mutation+pathway+independent+of+microsatellite+instability.&rft.au=Ferro%2C+P%3BCatalano%2C+M+G%3BRaineri%2C+M%3BReato%2C+G%3Bdell%27Eva%2C+R%3BRisio%2C+M%3BFo%C3%A0%2C+R%3BFortunati%2C+N%3BPfeffer%2C+U&rft.aulast=Ferro&rft.aufirst=P&rft.date=2000-11-01&rft.volume=123&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Cancer+genetics+and+cytogenetics&rft.issn=01654608&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2001-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of a ras oncogene peptide that contains both CD4(+) and CD8(+) T cell epitopes in a nested configuration and elicits both T cell subset responses by peptide or DNA immunization. AN - 72459453; 11104579 AB - Mutations in ras proto-oncogenes are commonly found in a diversity of malignancies and may encode unique, non-self epitopes for T cell-mediated antitumor activity. In a BALB/c (H-2(d)) murine model, we have identified a single peptide sequence derived from the ras oncogenes that contained both CD8(+) and CD4(+) T cell epitopes in a nested configuration. This peptide reflected ras sequence 4-16, and contained the substitution of Gly to Val at position 12 ¿i.e., 4-16(Val12)¿. Mice immunized with this 13-mer peptide induced a strong antigen (Ag)-specific CD4(+) proliferative response in vitro. In contrast, mice inoculated with the wild-type ras sequence failed to generate a peptide-specific T cell response. Additionally, mice immunized with the ras 4-16(Val12) peptide concomitantly displayed an Ag-specific CD8(+) cytotoxic T lymphocyte (CTL) response, as determined by lysis of syngeneic tumor target cells incubated with the nominal 9-mer nested epitope peptide ¿i.e., 4-12(Val12)¿, as well as lysis of tumor target cells expressing the corresponding ras codon 12 mutation. Analysis of the Valpha- and Vbeta-chains of the T cell receptor (TCR) expressed by these CTL revealed usage of the Valpha1 and Vbeta9 subunits, consistent with the TCR phenotype of anti-ras Val12 CTL lines produced by in vivo immunization with the nominal peptide epitope alone. Moreover, immunization with the nested epitope peptide, as compared to immunization with either the 9-mer CTL peptide alone or an admixture of the 9-mer CTL peptide with an overlapping 13-mer CD4(+) T cell helper peptide ¿i.e., 5-17(Val12)¿ lacking the class I N-terminus anchor site, enhanced the production of the CD8(+) T cell response. Finally, immunization with plasmid DNA encoding the ras 4-16(Val12) sequence led to the induction of both Ag-specific proliferative and cytotoxic responses. Overall, these results suggested that a single peptide immunogen containing nested mutant ras-specific CD4(+) and CD8(+) T cell epitopes: (1) can be processed in vivo to induce both subset-specific T lymphocyte responses; and (2) leads to the generation of a quantitatively enhanced CD8(+) CTL response, likely due to the intimate coexistence of CD4(+) help, which may have implications in peptide- or DNA-based immunotherapies. Copyright 2000 Academic Press. JF - Cellular immunology AU - Bristol, J A AU - Orsini, C AU - Lindinger, P AU - Thalhamer, J AU - Abrams, S I AD - Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 73 EP - 83 VL - 205 IS - 2 SN - 0008-8749, 0008-8749 KW - Cancer Vaccines KW - 0 KW - Epitopes, T-Lymphocyte KW - Peptides KW - Vaccines, DNA KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Peptides -- immunology KW - Mice KW - Peptides -- genetics KW - Mice, Inbred BALB C KW - Vaccination KW - Female KW - Mutagenesis KW - Vaccines, DNA -- immunology KW - Cancer Vaccines -- immunology KW - CD8-Positive T-Lymphocytes -- immunology KW - Proto-Oncogene Proteins p21(ras) -- immunology KW - CD4-Positive T-Lymphocytes -- immunology KW - Epitopes, T-Lymphocyte -- immunology KW - Proto-Oncogene Proteins p21(ras) -- genetics KW - Epitopes, T-Lymphocyte -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72459453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+immunology&rft.atitle=Identification+of+a+ras+oncogene+peptide+that+contains+both+CD4%28%2B%29+and+CD8%28%2B%29+T+cell+epitopes+in+a+nested+configuration+and+elicits+both+T+cell+subset+responses+by+peptide+or+DNA+immunization.&rft.au=Bristol%2C+J+A%3BOrsini%2C+C%3BLindinger%2C+P%3BThalhamer%2C+J%3BAbrams%2C+S+I&rft.aulast=Bristol&rft.aufirst=J&rft.date=2000-11-01&rft.volume=205&rft.issue=2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Cellular+immunology&rft.issn=00088749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-25 N1 - Date created - 2000-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study. AN - 72433044; 11097231 AB - Pancreatic cancer is a highly fatal cancer with few identified risk factors. Increased risk of pancreatic cancer in tobacco smokers and among diabetic patients is well established, and some reports have suggested associations with coffee consumption and occupational exposure to organochlorines. At present, there is little information regarding the possible association of these risk factors with the known genetic alterations found in pancreatic cancers, such as activation of the K-ras oncogene and inactivation of the p53 tumor suppressor gene. Knowledge of such relationships may help to understand the molecular pathways of pancreatic tumorigenesis. We investigated the association between these molecular defects and risk factors for pancreatic cancer in 61 newly diagnosed patients identified through an ongoing study of pancreatic cancer in the San Francisco Bay Area. Interview information was obtained regarding environmental exposures, medical history, and demographic factors. Serum levels of dichlorodiphenyltrichloroethylene (DDE) and polychlorinated biphenyls were available on a subset of 24 patients. Tumor blocks were located from local hospitals and used for K-ras mutational analysis at codon 12 and for p53 protein immunohistochemistry. The molecular analyses were facilitated through the use of laser capture microdissection, which provides a reliable method to obtain almost pure populations of tumor cells. Mutations in K-ras codon 12 were found in 46 (75%) of 61 pancreatic cancers. A prior diagnosis of diabetes was significantly associated with K-ras negative tumors (P = 0.002, Fisher's exact test). The absence of this mutation was also associated with increased serum levels of DDE, although this association was not statistically significant (P = 0.16, Wilcoxon's test). There was no difference in polychlorinated biphenyl levels between the K-ras wild-type and mutant groups. Immunohistochemical staining for p53 protein did not differ by patient characteristics or clinical history, but significant associations were found with poor glandular differentiation (P = 0.002, chi2 trend test), severe nuclear atypia (P = 0.0007, chi2 trend test), and high tumor grade (P = 0.004, chi2 trend test). Our results are suggestive of the presence of K-ras codon 12 mutation-independent tumorigenesis pathways in patients with prior diabetes and possibly in patients with higher serum levels of DDE. Our results also support a role for the p53 tumor suppressor protein in the maintenance of genomic integrity. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Slebos, R J AU - Hoppin, J A AU - Tolbert, P E AU - Holly, E A AU - Brock, J W AU - Zhang, R H AU - Bracci, P M AU - Foley, J AU - Stockton, P AU - McGregor, L M AU - Flake, G P AU - Taylor, J A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1223 EP - 1232 VL - 9 IS - 11 SN - 1055-9965, 1055-9965 KW - Carcinogens KW - 0 KW - Insecticides KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Index Medicus KW - DNA Mutational Analysis KW - Humans KW - Aged KW - Dichlorodiphenyl Dichloroethylene -- adverse effects KW - Medical History Taking KW - Insecticides -- adverse effects KW - Risk Factors KW - Case-Control Studies KW - Middle Aged KW - Immunohistochemistry KW - Diabetes Complications KW - Female KW - Male KW - Genes, ras -- genetics KW - Genes, p53 -- genetics KW - Environmental Exposure KW - Pancreatic Neoplasms -- genetics KW - Pancreatic Neoplasms -- etiology KW - Carcinogens -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72433044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=K-ras+and+p53+in+pancreatic+cancer%3A+association+with+medical+history%2C+histopathology%2C+and+environmental+exposures+in+a+population-based+study.&rft.au=Slebos%2C+R+J%3BHoppin%2C+J+A%3BTolbert%2C+P+E%3BHolly%2C+E+A%3BBrock%2C+J+W%3BZhang%2C+R+H%3BBracci%2C+P+M%3BFoley%2C+J%3BStockton%2C+P%3BMcGregor%2C+L+M%3BFlake%2C+G+P%3BTaylor%2C+J+A&rft.aulast=Slebos&rft.aufirst=R&rft.date=2000-11-01&rft.volume=9&rft.issue=11&rft.spage=1223&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors. AN - 72431352; 11089548 AB - Naturally occurring mutations identified in subjects with autosomal dominant hypocalcemia (ADH) and the calcimimetic compound, R-568, have both been reported to increase Ca2+ sensitivity of the Ca2+ receptor (CaR). To gain insight into their mechanism of action, we studied interactions between four different ADH mutations located in the amino-terminal extracellular domain (ECD) and R-568. We found that R-568 increased the sensitivity of three of the ADH mutant receptors, but the Leu125Pro mutant appeared to be maximally left-shifted in that neither R-568 addition nor combining other ADH mutations with Leu125Pro gave increases in sensitivity comparable to those seen with the three other ADH mutations studied. We also made use of truncation and deletion mutants of the CaR and CaR/metabotropic glutamate receptor type 1 (mGluR1) chimeras to study both the site of action of R-568 and the effect of the Leu125Pro activating mutation. R-568 was effective in receptor constructs containing the seven transmembrane domain (7TM) of the CaR, but not in those containing the mGluR1 7TM. R-568, moreover, imparted Ca2+ responsiveness to CaR constructs lacking all or part of the CaR ECD. The Leu125Pro mutation in contrast conferred no or minimal increase in Ca2+ responsiveness to CaR constructs lacking part of the CaR ECD but showed a striking increase in basal activity in the context of chimeras containing an mGluR1 7TM. Our results localize the site of action of NPS-568 specifically to the CaR 7TM. Our results with the Leu125Pro mutant, furthermore, suggest that the mGluR1 7TM domain may be more permissive for activation than the 7TM domain of the CaR. JF - Endocrinology AU - Hauache, O M AU - Hu, J AU - Ray, K AU - Xie, R AU - Jacobson, K A AU - Spiegel, A M AD - Metabolic Diseases Branch NIDDK, NIH, Bethesda, Maryland 20892, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 4156 EP - 4163 VL - 141 IS - 11 SN - 0013-7227, 0013-7227 KW - Aniline Compounds KW - 0 KW - Calcium-Binding Proteins KW - N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine KW - Phenethylamines KW - Phosphatidylinositols KW - Propylamines KW - Receptors, Metabotropic Glutamate KW - Recombinant Fusion Proteins KW - Calcium KW - SY7Q814VUP KW - Abridged Index Medicus KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Phosphatidylinositols -- metabolism KW - Immunoblotting KW - Transfection KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Hydrolysis KW - Gene Deletion KW - Calcium -- agonists KW - Aniline Compounds -- pharmacology KW - Receptors, Metabotropic Glutamate -- genetics KW - Receptors, Metabotropic Glutamate -- metabolism KW - Receptors, Metabotropic Glutamate -- drug effects KW - Calcium -- pharmacology KW - Calcium-Binding Proteins -- genetics KW - Calcium-Binding Proteins -- drug effects KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72431352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Effects+of+a+calcimimetic+compound+and+naturally+activating+mutations+on+the+human+Ca2%2B+receptor+and+on+Ca2%2B+receptor%2Fmetabotropic+glutamate+chimeric+receptors.&rft.au=Hauache%2C+O+M%3BHu%2C+J%3BRay%2C+K%3BXie%2C+R%3BJacobson%2C+K+A%3BSpiegel%2C+A+M&rft.aulast=Hauache&rft.aufirst=O&rft.date=2000-11-01&rft.volume=141&rft.issue=11&rft.spage=4156&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Issues for discussion: benzene-induced leukemia--human studies. AN - 72430823; 11086953 JF - Journal of toxicology and environmental health. Part A AU - Bayliss, D AU - Sonawane, B AD - National Center for Environmental Assessment, US Environmental Protection Agency, National Cancer Institute/Chinese Epidemiologic Study. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 467 EP - 470 VL - 61 IS - 5-6 SN - 1528-7394, 1528-7394 KW - Biomarkers, Tumor KW - 0 KW - Petroleum KW - Benzene KW - J64922108F KW - Index Medicus KW - Occupational Exposure KW - Extraction and Processing Industry KW - Humans KW - China -- epidemiology KW - Biomarkers, Tumor -- analysis KW - Occupational Diseases -- epidemiology KW - United States -- epidemiology KW - Occupational Diseases -- chemically induced KW - Epidemiology -- standards KW - Leukemia -- chemically induced KW - Leukemia -- epidemiology KW - Benzene -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72430823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Issues+for+discussion%3A+benzene-induced+leukemia--human+studies.&rft.au=Bayliss%2C+D%3BSonawane%2C+B&rft.aulast=Bayliss&rft.aufirst=D&rft.date=2000-11-01&rft.volume=61&rft.issue=5-6&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concerted regulation of steroidogenic acute regulatory gene expression by luteinizing hormone and insulin (or insulin-like growth factor I) in primary cultures of porcine granulosa-luteal cells. AN - 72430427; 11089528 AB - The steroidogenic acute regulatory (StAR) protein is indispensable for maximal trophic hormone-stimulated steroidogenesis by the adrenal gland, testis, and ovary. Recently, our laboratory developed an in vitro primary culture system of porcine granulosa-luteal cells that retain responsiveness to LH and show LH and insulin [or insulin-like growth factor (IGF-I)] synergy in stimulating StAR messenger RNA accumulation. Here, we examine the mechanisms subserving this LH-insulin (IGF-I) augmentation. We corroborate LH's amplification of insulin as well as IGF-I-stimulated granulosa-luteal cell progesterone and cAMP accumulation (P < 0.001). Insulin or IGF-I elevated LH receptor transcript accumulation, and LH did not alter this effect. To determine the hormonal responsiveness of StAR promoter, truncated regions of the -1423 to +130 bp upstream sequence of the porcine gene were ligated into a firefly luciferase reporter plasmid. Transient transfection of the StAR plasmid containing the full-length porcine 5'-flanking region of StAR (pStAR1423/luc) showed superadditive stimulation by LH and insulin or IGF-I after 24 h. LH, but not insulin or IGF-I alone, stimulated pStAR1423/luc activity. Deletion of the proximal putative steroidogenic factor-1 (-48 to -41) site abolished hormonally driven StAR promoter activity. A stable cAMP analog, 8-bromo-cAMP (1 mM), and insulin/IGF-I also evoked supraadditive StAR promoter expression. To further explore the role of cAMP in LH-insulin (or IGF-I) actions, we cotransfected a Rous sarcoma virus (RSV)-driven minigene encoding the heat-stable inhibitor of the cAMP-dependent protein kinase (RSV/PKI) or a mutant plasmid (RSV/PKImut) along with the pStAR1423/luc promoter construct. Cotransfection of PKI, but not PKImut, with pStAR1423/luc significantly attenuated LH's stimulation of luciferase activity and also reduced the magnitude of the transcriptional amplification exerted by LH and insulin or IGF-I. In corollary analyses of the protein kinase A (PKA) pathway, cotransfection of full-length pStAR1423/luc and a complementary DNA encoding a constitutively activated PKA catalytic subunit elevated basal and insulin (or IGF-I)-stimulated StAR promoter expression. LH and insulin (or IGF-I) also augmented steady state StAR transcript levels, as assessed by homologous RT-PCR, and StAR protein concentrations, as evaluated by Western blotting. Together, these investigations document a significant role for insulin or IGF-I in enhancing LH-stimulated progesterone and cAMP biosynthesis and endogenous StAR message and protein accumulation and in augmenting cAMP-PKA-dependent transcriptional activation of the exogenous StAR promoter. JF - Endocrinology AU - Sekar, N AU - Lavoie, H A AU - Veldhuis, J D AD - Department of Internal Medicine, National Institutes of Health Specialized Cooperative Center in Reproductive Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 3983 EP - 3992 VL - 141 IS - 11 SN - 0013-7227, 0013-7227 KW - Insulin KW - 0 KW - Phosphoproteins KW - RNA, Messenger KW - Receptors, LH KW - Recombinant Fusion Proteins KW - steroidogenic acute regulatory protein KW - 8-Bromo Cyclic Adenosine Monophosphate KW - 23583-48-4 KW - Progesterone KW - 4G7DS2Q64Y KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Luteinizing Hormone KW - 9002-67-9 KW - Cyclic AMP KW - E0399OZS9N KW - Luciferases KW - EC 1.13.12.- KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Abridged Index Medicus KW - Index Medicus KW - Swine KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Animals KW - Receptors, LH -- genetics KW - Cyclic AMP-Dependent Protein Kinases -- genetics KW - 8-Bromo Cyclic Adenosine Monophosphate -- pharmacology KW - Insulin-Like Growth Factor I -- pharmacology KW - Promoter Regions, Genetic KW - RNA, Messenger -- metabolism KW - Transfection KW - Cells, Cultured KW - Progesterone -- metabolism KW - Cyclic AMP -- metabolism KW - Drug Synergism KW - Luciferases -- genetics KW - Female KW - Phosphoproteins -- genetics KW - Luteinizing Hormone -- pharmacology KW - Insulin -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Luteal Cells -- metabolism KW - Granulosa Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72430427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Concerted+regulation+of+steroidogenic+acute+regulatory+gene+expression+by+luteinizing+hormone+and+insulin+%28or+insulin-like+growth+factor+I%29+in+primary+cultures+of+porcine+granulosa-luteal+cells.&rft.au=Sekar%2C+N%3BLavoie%2C+H+A%3BVeldhuis%2C+J+D&rft.aulast=Sekar&rft.aufirst=N&rft.date=2000-11-01&rft.volume=141&rft.issue=11&rft.spage=3983&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin. AN - 72427992; 11085528 AB - Matrix metalloproteinases (MMPs) are overexpressed in a variety of tumor tissues and cell lines, and their expression is highly correlated to tumor invasion and metastasis. To exploit these characteristics in the design of tumor cell-selective cytotoxins, we constructed two mutated anthrax toxin protective antigen (PA) proteins in which the furin protease cleavage site is replaced by sequences selectively cleaved by MMPs. These MMP-targeted PA proteins were activated rapidly and selectively on the surface of MMP-overexpressing tumor cells. The activated PA proteins caused internalization of a recombinant cytotoxin, FP59, consisting of anthrax toxin lethal factor residues 1-254 fused to the ADP-ribosylation domain of Pseudomonas exotoxin A. The toxicity of the mutated PA proteins for MMP-overexpressing cells was blocked by hydroxamate inhibitors of MMPs, including BB94, and by a tissue inhibitor of matrix metalloproteinases (TIMP-2). The mutated PA proteins killed MMP-overexpressing tumor cells while sparing nontumorigenic normal cells when these were grown together in a coculture model, indicating that PA activation occurred on the tumor cell surface and not in the supernatant. This method of achieving cell-type specificity is conceptually distinct from, and potentially synergistic with, the more common strategy of retargeting a protein toxin by fusion to a growth factor, cytokine, or antibody. JF - Cancer research AU - Liu, S AU - Netzel-Arnett, S AU - Birkedal-Hansen, H AU - Leppla, S H AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4350, USA. Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 6061 EP - 6067 VL - 60 IS - 21 SN - 0008-5472, 0008-5472 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - anthrax toxin KW - Matrix Metalloproteinases KW - EC 3.4.24.- KW - Matrix Metalloproteinases, Membrane-Associated KW - Metalloendopeptidases KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Index Medicus KW - Breast Neoplasms -- drug therapy KW - Animals KW - Coculture Techniques KW - Vero Cells -- enzymology KW - Melanoma -- enzymology KW - Humans KW - Fibrosarcoma -- drug therapy KW - Amino Acid Sequence KW - Matrix Metalloproteinase 9 -- biosynthesis KW - Matrix Metalloproteinase 2 -- metabolism KW - Matrix Metalloproteinase 2 -- biosynthesis KW - Binding Sites KW - COS Cells -- enzymology KW - Matrix Metalloproteinase 9 -- metabolism KW - Tumor Cells, Cultured KW - Biotransformation KW - Melanoma -- drug therapy KW - Cercopithecus aethiops KW - Fibrosarcoma -- enzymology KW - Metalloendopeptidases -- metabolism KW - Metalloendopeptidases -- biosynthesis KW - Breast Neoplasms -- enzymology KW - Mutation KW - Bacterial Toxins -- genetics KW - Bacterial Toxins -- pharmacokinetics KW - Matrix Metalloproteinases -- metabolism KW - Matrix Metalloproteinases -- biosynthesis KW - Bacterial Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72427992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Tumor+cell-selective+cytotoxicity+of+matrix+metalloproteinase-activated+anthrax+toxin.&rft.au=Liu%2C+S%3BNetzel-Arnett%2C+S%3BBirkedal-Hansen%2C+H%3BLeppla%2C+S+H&rft.aulast=Liu&rft.aufirst=S&rft.date=2000-11-01&rft.volume=60&rft.issue=21&rft.spage=6061&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comments on a biochemical model of cyclophosphamide hematotoxicity. AN - 72426500; 11086963 JF - Journal of toxicology and environmental health. Part A AU - Portier, C J AU - Parham, F M AD - Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. portier@niehs.nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 525 EP - 528 VL - 61 IS - 5-6 SN - 1528-7394, 1528-7394 KW - Immunosuppressive Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Hematologic Diseases -- chemically induced KW - Animals KW - Reproducibility of Results KW - Hematopoiesis -- drug effects KW - Humans KW - Granulocytes -- drug effects KW - Mice KW - Granulocytes -- cytology KW - Immunosuppressive Agents -- toxicity KW - Hematopoietic Stem Cells -- cytology KW - Cyclophosphamide -- toxicity KW - Cyclophosphamide -- pharmacokinetics KW - Models, Biological KW - Immunosuppressive Agents -- pharmacokinetics KW - Proportional Hazards Models KW - Hematopoietic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72426500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Comments+on+a+biochemical+model+of+cyclophosphamide+hematotoxicity.&rft.au=Portier%2C+C+J%3BParham%2C+F+M&rft.aulast=Portier&rft.aufirst=C&rft.date=2000-11-01&rft.volume=61&rft.issue=5-6&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Toxicol Environ Health A. 2000 Nov;61(5-6):501-10 [11086959] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Benzene and lymphohematopoietic malignancies in China. AN - 72424886; 11086948 AB - While this study is larger than previous investigations and includes workers with a wide range of exposures to benzene, the estimates of risk, as measured by statistical confidence intervals, are still fairly broad, and would benefit from the larger numbers that could be provided by continued follow-up of this population. Nevertheless, the study confirms earlier findings of increased risk for ANLL and aplastic anemia among benzene-exposed workers, provides the first substantial evidence that MDS is linked to benzene exposure, and provides evidence that benzene increases risk for ANLL/MDS at lower levels of exposure than had previously been demonstrated. Currently we are evaluating the potential for extending the follow-up of workers included in this study. A new study would include expanded data collection for cases of hematopoietic malignancy and related disorders and for an appropriate control series. JF - Journal of toxicology and environmental health. Part A AU - Hayes, R B AU - Yin, S AU - Rothman, N AU - Dosemeci, M AU - Li, G AU - Travis, L T AU - Smith, M T AU - Linet, M S AD - Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, Maryland 20892, USA. hayesr@mail.nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 419 EP - 432 VL - 61 IS - 5-6 SN - 1528-7394, 1528-7394 KW - Carcinogens KW - 0 KW - Benzene KW - J64922108F KW - Index Medicus KW - Anemia, Aplastic -- epidemiology KW - Anemia, Aplastic -- chemically induced KW - Dose-Response Relationship, Drug KW - Humans KW - Leukemia, Myeloid, Acute -- chemically induced KW - Myelodysplastic Syndromes -- chemically induced KW - Lymphoma, Non-Hodgkin -- chemically induced KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Leukemia, Myeloid -- chemically induced KW - Leukemia, Myeloid -- epidemiology KW - Leukemia, Myeloid, Acute -- epidemiology KW - China -- epidemiology KW - Adult KW - Cohort Studies KW - Occupational Exposure -- adverse effects KW - Myelodysplastic Syndromes -- epidemiology KW - Follow-Up Studies KW - Male KW - Female KW - Hematologic Neoplasms -- chemically induced KW - Occupational Diseases -- epidemiology KW - Hematologic Neoplasms -- epidemiology KW - Occupational Diseases -- chemically induced KW - Benzene -- adverse effects KW - Carcinogens -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72424886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Benzene+and+lymphohematopoietic+malignancies+in+China.&rft.au=Hayes%2C+R+B%3BYin%2C+S%3BRothman%2C+N%3BDosemeci%2C+M%3BLi%2C+G%3BTravis%2C+L+T%3BSmith%2C+M+T%3BLinet%2C+M+S&rft.aulast=Hayes&rft.aufirst=R&rft.date=2000-11-01&rft.volume=61&rft.issue=5-6&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. AN - 72420049; 11069615 AB - To produce conditional expression of genes in the mouse epidermis we have generated transgenic mouse lines in which the tetracycline-regulated transcriptional transactivators, tTA and rTA, are linked to the bovine keratin 5 promoter. The transactivator lines were crossed with the tetOlacZ indicator line to test for transactivation in vivo. In the absence of doxycycline, the K5/tTA line induced beta-galactosidase enzyme activity in the epidermis at a level 500-fold higher than controls, and oral and topical doxycycline caused a dose- and time-dependent suppression of beta-galactosidase mRNA levels and enzyme activity. In the K5/rTA lines, doxycycline induced beta-galactosidase activity between 3- and 50-fold higher depending on the founder line, and this occurred within 24-48 h after dosing. Histochemical analysis of all lines localized beta-galactosidase expression to the basal layer of the epidermis and the outer root sheath of the hair follicle, as well as other keratin 5 positive tissues. In several K5/rTA lines, skin-specific transactivation was restricted to the hair follicle. Treatment of these double transgenic mice with 12-O-tetradecanoyl-phorbol-13-acetate caused rapid migration of beta-galactosidase marked cells from the hair follicle through the interfollicular epidermis, demonstrating the usefulness of this specific double transgenic for fate mapping cells in the epidermis. These results show that the tetracycline regulatory system produces effective conditional gene expression in the mouse epidermis, and suggest that it should be amenable to suppression and activation of foreign genes during development and specific pathologic conditions relevant to the epidermis. JF - The Journal of investigative dermatology AU - Diamond, I AU - Owolabi, T AU - Marco, M AU - Lam, C AU - Glick, A AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 788 EP - 794 VL - 115 IS - 5 SN - 0022-202X, 0022-202X KW - Trans-Activators KW - 0 KW - Keratins KW - 68238-35-7 KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Tetracycline KW - F8VB5M810T KW - Doxycycline KW - N12000U13O KW - Index Medicus KW - Keratins -- genetics KW - Genetic Linkage KW - Cell Movement KW - Animals KW - Promoter Regions, Genetic KW - Hair Follicle -- cytology KW - Gene Expression KW - Doxycycline -- pharmacology KW - Transcriptional Activation -- drug effects KW - beta-Galactosidase -- genetics KW - Mice KW - Trans-Activators -- pharmacology KW - Trans-Activators -- genetics KW - Tetracycline -- pharmacology KW - Mice, Transgenic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72420049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Conditional+gene+expression+in+the+epidermis+of+transgenic+mice+using+the+tetracycline-regulated+transactivators+tTA+and+rTA+linked+to+the+keratin+5+promoter.&rft.au=Diamond%2C+I%3BOwolabi%2C+T%3BMarco%2C+M%3BLam%2C+C%3BGlick%2C+A&rft.aulast=Diamond&rft.aufirst=I&rft.date=2000-11-01&rft.volume=115&rft.issue=5&rft.spage=788&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-28 N1 - Date created - 2000-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development. AN - 72419264; 11081567 AB - 5-Fluorouracil (5-FU) and 5-fluoro-2'-deoxyuridine (FdUrd) are pyrimidine analogs that have been part of the therapeutic armamentarium for a variety of solid tumors for over forty years. 5-FU has customarily required intravenous administration due to poor and erratic oral bioavailability, while FdUrd has generally been employed for regional administration to the liver or the peritoneal cavity. A great deal of knowledge has been gained concerning the cellular pharmacology and mechanism of action of 5-FU since it was first synthesized in the late 1950's. A more thorough understanding of the factors influencing the metabolic activation of 5-FU and its cellular effects has generated considerable interest in combining it with both modulatory agents such as leucovorin and methotrexate that enhance its metabolism or cytotoxic effects. In addition, 5-FU has also been employed to enhance the therapeutic activity of other antineoplastic agents or modalities such as cisplatin and ionizing radiation with which it can synergize. Appreciation of the clinical pharmacology of 5-FU and FdUrd have led to a variety of schedules that are clinically useful. The preclinical and clinical pharmacology of 5-FU is reviewed to provide a basis for exploring the novel approaches to permit oral administration of 5-FU or its prodrugs that will be described in other articles in this issue. JF - Investigational new drugs AU - Grem, J L AD - Developmental Therapeutics Department, National Cancer Institute- Medicine Branch, National Naval Medical Center, Bethesda, MD 20889, USA. jgrem@helix.nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 299 EP - 313 VL - 18 IS - 4 SN - 0167-6997, 0167-6997 KW - Antimetabolites, Antineoplastic KW - 0 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Animals KW - Humans KW - Clinical Trials as Topic KW - Fluorouracil -- toxicity KW - Antimetabolites, Antineoplastic -- toxicity KW - Fluorouracil -- pharmacology KW - Fluorouracil -- metabolism KW - Antimetabolites, Antineoplastic -- metabolism KW - Antimetabolites, Antineoplastic -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72419264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=5-Fluorouracil%3A+forty-plus+and+still+ticking.+A+review+of+its+preclinical+and+clinical+development.&rft.au=Grem%2C+J+L&rft.aulast=Grem&rft.aufirst=J&rft.date=2000-11-01&rft.volume=18&rft.issue=4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. AN - 72418991; 11085536 AB - We used overlapping and nested homozygous deletions, contig building, genomic sequencing, and physical and transcript mapping to further define a approximately 630-kb lung cancer homozygous deletion region harboring one or more tumor suppressor genes (TSGs) on chromosome 3p21.3. This location was identified through somatic genetic mapping in tumors, cancer cell lines, and premalignant lesions of the lung and breast, including the discovery of several homozygous deletions. The combination of molecular manual methods and computational predictions permitted us to detect, isolate, characterize, and annotate a set of 25 genes that likely constitute the complete set of protein-coding genes residing in this approximately 630-kb sequence. A subset of 19 of these genes was found within the deleted overlap region of approximately 370-kb. This region was further subdivided by a nesting 200-kb breast cancer homozygous deletion into two gene sets: 8 genes lying in the proximal approximately 120-kb segment and 11 genes lying in the distal approximately 250-kb segment. These 19 genes were analyzed extensively by computational methods and were tested by manual methods for loss of expression and mutations in lung cancers to identify candidate TSGs from within this group. Four genes showed loss-of-expression or reduced mRNA levels in non-small cell lung cancer (CACNA2D2/alpha2delta-2, SEMA3B [formerly SEMA(V), BLU, and HYAL1] or small cell lung cancer (SEMA3B, BLU, and HYAL1) cell lines. We found six of the genes to have two or more amino acid sequence-altering mutations including BLU, NPRL2/Gene21, FUS1, HYAL1, FUS2, and SEMA3B. However, none of the 19 genes tested for mutation showed a frequent (>10%) mutation rate in lung cancer samples. This led us to exclude several of the genes in the region as classical tumor suppressors for sporadic lung cancer. On the other hand, the putative lung cancer TSG in this location may either be inactivated by tumor-acquired promoter hypermethylation or belong to the novel class of haploinsufficient genes that predispose to cancer in a hemizygous (+/-) state but do not show a second mutation in the remaining wild-type allele in the tumor. We discuss the data in the context of novel and classic cancer gene models as applied to lung carcinogenesis. Further functional testing of the critical genes by gene transfer and gene disruption strategies should permit the identification of the putative lung cancer TSG(s), LUCA, Analysis of the approximately 630-kb sequence also provides an opportunity to probe and understand the genomic structure, evolution, and functional organization of this relatively gene-rich region. JF - Cancer research AU - Lerman, M I AU - Minna, J D AD - Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA. lerman@ncifcrf.gov Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 6116 EP - 6133 VL - 60 IS - 21 SN - 0008-5472, 0008-5472 KW - DNA, Neoplasm KW - 0 KW - Index Medicus KW - Gene Expression Profiling KW - Homozygote KW - Tumor Cells, Cultured KW - Humans KW - DNA Mutational Analysis KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Computational Biology -- methods KW - DNA, Neoplasm -- genetics KW - Chromosome Mapping -- methods KW - Carcinoma, Small Cell -- genetics KW - Gene Deletion KW - Cloning, Molecular KW - Genes, Tumor Suppressor -- genetics KW - Chromosomes, Human, Pair 3 -- genetics KW - Lung Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72418991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=The+630-kb+lung+cancer+homozygous+deletion+region+on+human+chromosome+3p21.3%3A+identification+and+evaluation+of+the+resident+candidate+tumor+suppressor+genes.+The+International+Lung+Cancer+Chromosome+3p21.3+Tumor+Suppressor+Gene+Consortium.&rft.au=Lerman%2C+M+I%3BMinna%2C+J+D&rft.aulast=Lerman&rft.aufirst=M&rft.date=2000-11-01&rft.volume=60&rft.issue=21&rft.spage=6116&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Technique and results of hyperthermic isolated hepatic perfusion with tumor necrosis factor and melphalan for the treatment of unresectable hepatic malignancies. AN - 72417917; 11085732 AB - For a variety of histologies, the liver represents the only or the dominant site of metastatic disease. Regional treatment of the liver has the theoretic advantage of maximizing drug delivery while minimizing systemic toxicity. This article describes the technique of isolated hepatic perfusion using tumor necrosis factor and melphalan under conditions of moderate hyperthermia for the treatment of unresectable liver tumors. Fifty patients with biopsy-proved unresectable primary or metastatic cancer to the liver were treated. Isolated hepatic perfusion was performed for 60 minutes under conditions of moderate hyperthermia during a laparotomy with inflow through the gastroduodenal artery and outflow through an isolated segment of inferior vena cava. During isolated hepatic perfusion portal and infrahepatic blood flow were shunted externally by a centrifugal pump to the axillary vein. Complete vascular isolation was confirmed intraoperatively using a continuous 131I-labeled serum albumin leak monitoring system. Operative and perfusion parameters were recorded. By using a standard operative technique to achieve complete vascular isolation of the liver during perfusion, there was no leak ofperfusate detected in 48 of 50 patients as determined by the continuous leak monitoring system and absence of detectable systemic tumor necrosis factor levels. Operating time, transfusion requirements, and blood loss were within the range expected for a major operative procedure. Stable hemodynamic and perfusion parameters were achieved consistently and all patients successfully completed the 60-minute perfusion. Two patients (4%) died as a result of treatment and significant tumor regression was observed in 75%. Isolated hepatic perfusion is a technique that can be used to deliver high doses of chemotherapy or biologic therapy regionally and without systemic exposure. By using a standard operative technique, continuous intraoperative leak monitoring, and an external veno-veno bypass circuit, this procedure can be done safely and with acceptable morbidity and mortality. This article demonstrates that sustained and complete vascular isolation of the liver can be achieved and indicates further study is warranted to better define the role of isolated hepatic perfusion in the treatment of unresectable liver tumors. JF - Journal of the American College of Surgeons AU - Libutti, S K AU - Barlett, D L AU - Fraker, D L AU - Alexander, H R AD - Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1502, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 519 EP - 530 VL - 191 IS - 5 SN - 1072-7515, 1072-7515 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Serum Albumin, Radio-Iodinated KW - Tumor Necrosis Factor-alpha KW - Melphalan KW - Q41OR9510P KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Aged KW - Serum Albumin, Radio-Iodinated -- administration & dosage KW - Middle Aged KW - Male KW - Female KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Liver Neoplasms -- therapy KW - Melphalan -- administration & dosage KW - Melphalan -- adverse effects KW - Hyperthermia, Induced -- adverse effects KW - Antineoplastic Agents, Alkylating -- adverse effects KW - Tumor Necrosis Factor-alpha -- adverse effects KW - Antineoplastic Agents, Alkylating -- administration & dosage KW - Chemotherapy, Cancer, Regional Perfusion -- methods KW - Chemotherapy, Cancer, Regional Perfusion -- adverse effects KW - Liver Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72417917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Surgeons&rft.atitle=Technique+and+results+of+hyperthermic+isolated+hepatic+perfusion+with+tumor+necrosis+factor+and+melphalan+for+the+treatment+of+unresectable+hepatic+malignancies.&rft.au=Libutti%2C+S+K%3BBarlett%2C+D+L%3BFraker%2C+D+L%3BAlexander%2C+H+R&rft.aulast=Libutti&rft.aufirst=S&rft.date=2000-11-01&rft.volume=191&rft.issue=5&rft.spage=519&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Surgeons&rft.issn=10727515&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Benzene leukemogenesis: an environmental carcinogen-induced tissue-specific model of neoplasia using genetically altered mouse models. AN - 72415209; 11086942 JF - Journal of toxicology and environmental health. Part A AU - French, J E AU - Saulnier, M AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. french@niehs.nih.com Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 377 EP - 379 VL - 61 IS - 5-6 SN - 1528-7394, 1528-7394 KW - Carcinogens, Environmental KW - 0 KW - Benzene KW - J64922108F KW - Index Medicus KW - Animals KW - Neoplasms, Experimental -- chemically induced KW - Neoplasms, Experimental -- genetics KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Organ Specificity KW - Mice KW - Female KW - Benzene -- toxicity KW - Carcinogens, Environmental -- toxicity KW - Mice, Transgenic KW - Leukemia, Experimental -- chemically induced KW - Leukemia, Experimental -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72415209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Benzene+leukemogenesis%3A+an+environmental+carcinogen-induced+tissue-specific+model+of+neoplasia+using+genetically+altered+mouse+models.&rft.au=French%2C+J+E%3BSaulnier%2C+M&rft.aulast=French&rft.aufirst=J&rft.date=2000-11-01&rft.volume=61&rft.issue=5-6&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. AN - 72403083; 11075820 AB - The nuclear orphan receptor CAR (constitutively active receptor or constitutive androstane receptor) can be activated in response to xenochemical exposure, such as activation by phenobarbital of a response element called NR1 found in the CYP2B gene. Here various steroids were screened for potential endogenous chemicals that may activate CAR, using the NR1 enhancer and Cyp2b10 induction in transfected HepG2 cell and/or in mouse primary hepatocytes as the experimental criteria. 17beta-Estradiol and estrone activated NR1, whereas estriol, estetrol, estradiol sulfate, and the synthetic estrogen diethylstilbestrol did not. On the other hand, progesterone and androgens repressed NR1 activity in HepG2 cells, and the repressed NR1 activity was fully restored by estradiol. Moreover, estrogen treatment elicited nuclear accumulation of CAR in the mouse livers, as well as primary hepatocytes, and induced the endogenous Cyp2b10 gene. Ovariectomy did not affect either the basal or induced level of CAR in the nucleus of the female livers, while castration slightly increased the basal and greatly increased the induced levels in the liver nucleus of male mice. Thus, endogenous estrogen appears not to regulate CAR in female mice, whereas endogenous androgen may be the repressive factor in male mice. Estrogen at pharmacological levels is an effective activator of CAR in both female and male mice, suggesting a biological and/or toxicological role of this receptor in estrogen metabolism. In addition to mouse CAR, estrogens activated rat CAR, whereas human CAR did not respond well to the estrogens under the experimental conditions. JF - Molecular endocrinology (Baltimore, Md.) AU - Kawamoto, T AU - Kakizaki, S AU - Yoshinari, K AU - Negishi, M AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1897 EP - 1905 VL - 14 IS - 11 SN - 0888-8809, 0888-8809 KW - Androgens KW - 0 KW - Estrogens KW - Receptors, Cytoplasmic and Nuclear KW - Steroids KW - Transcription Factors KW - constitutive androstane receptor KW - Progesterone KW - 4G7DS2Q64Y KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Steroid Hydroxylases KW - EC 1.14.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cyp2b10 protein, mouse KW - Cytochrome P450 Family 2 KW - Index Medicus KW - Animals KW - Hepatocytes -- drug effects KW - Mice, Inbred ICR KW - Progesterone -- pharmacology KW - Humans KW - Steroids -- pharmacology KW - Mice KW - Androgens -- pharmacology KW - Rats KW - Transfection KW - Progesterone -- metabolism KW - Enhancer Elements, Genetic KW - Ovariectomy KW - Species Specificity KW - Androgens -- metabolism KW - Female KW - Male KW - Steroids -- metabolism KW - Hepatocytes -- metabolism KW - Estrogens -- pharmacology KW - Estrogens -- metabolism KW - Transcription Factors -- metabolism KW - Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- genetics KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Liver -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72403083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Estrogen+activation+of+the+nuclear+orphan+receptor+CAR+%28constitutive+active+receptor%29+in+induction+of+the+mouse+Cyp2b10+gene.&rft.au=Kawamoto%2C+T%3BKakizaki%2C+S%3BYoshinari%2C+K%3BNegishi%2C+M&rft.aulast=Kawamoto&rft.aufirst=T&rft.date=2000-11-01&rft.volume=14&rft.issue=11&rft.spage=1897&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-05-31 N1 - Date created - 2001-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bayesian analysis of mutational spectra. AN - 72394528; 11063712 AB - Studies that examine both the frequency of gene mutation and the pattern or spectrum of mutational changes can be used to identify chemical mutagens and to explore the molecular mechanisms of mutagenesis. In this article, we propose a Bayesian hierarchical modeling approach for the analysis of mutational spectra. We assume that the total number of independent mutations and the numbers of mutations falling into different response categories, defined by location within a gene and/or type of alteration, follow binomial and multinomial sampling distributions, respectively. We use prior distributions to summarize past information about the overall mutation frequency and the probabilities corresponding to the different mutational categories. These priors can be chosen on the basis of data from previous studies using an approach that accounts for heterogeneity among studies. Inferences about the overall mutation frequency, the proportions of mutations in each response category, and the category-specific mutation frequencies can be based on posterior distributions, which incorporate past and current data on the mutant frequency and on DNA sequence alterations. Methods are described for comparing groups and for assessing dose-related trends. We illustrate our approach using data from the literature. JF - Genetics AU - Dunson, D B AU - Tindall, K R AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. dunson1@niehs.nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1411 EP - 1418 VL - 156 IS - 3 SN - 0016-6731, 0016-6731 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Probability KW - Base Pairing KW - Animals KW - Humans KW - DNA -- genetics KW - Confidence Intervals KW - Models, Genetic KW - Bayes Theorem KW - Models, Statistical KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72394528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Bayesian+analysis+of+mutational+spectra.&rft.au=Dunson%2C+D+B%3BTindall%2C+K+R&rft.aulast=Dunson&rft.aufirst=D&rft.date=2000-11-01&rft.volume=156&rft.issue=3&rft.spage=1411&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 1997 Jan 1;25(1):136-7 [9016522] Environ Mol Mutagen. 1996;28(4):418-23 [8991072] Environ Mol Mutagen. 1998;31(1):48-54 [9464315] Toxicol Pathol. 1984;12(2):126-35 [11478313] Nature. 1982 Sep 23;299(5881):365-7 [6213867] J Mol Biol. 1987 Apr 5;194(3):391-6 [3305960] Mol Biol Evol. 1989 Sep;6(5):539-45 [2677600] Biometrics. 1992 Jun;48(2):459-78 [1637972] Environ Mol Mutagen. 1994;23(1):17-31 [8125080] Genetics. 1994 Jan;136(1):403-16 [8138174] Risk Anal. 1994 Aug;14(4):639-48 [7972964] Environ Mol Mutagen. 1994;24(4):276-82 [7851339] Environ Mol Mutagen. 1995;25(3):246-55 [7737142] Environ Mol Mutagen. 1996;28(4):405-13 [8991070] Environ Mol Mutagen. 1996;28(4):414-7 [8991071] Mutat Res. 1997 Feb 14;388(2-3):249-89 [9057887] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative reactions of anti 5,9-dimethylchrysene dihydrodiol epoxide with DNA and deoxyribonucleotides. AN - 72394231; 11064001 AB - Native as well as denatured calf thymus DNA, deoxyguanylic and deoxyadenylic acid, respectively, were reacted with the racemic anti 5,9-dimethylchrysene dihydrodiol epoxide (5,9-DMCDE). The deoxyribonucleoside adducts were separated by HPLC and characterized by CD and NMR. Approximately 17% of the epoxide was trapped by native DNA and 76% of the adducts were derived from the RSSR enantiomer. The ratios of dAdo/dGuo modification in DNA were 14/86 and 19/81 for RSSR and SRRS enantiomers, respectively. By monitoring the product yields of anti 5,9-DMCDE with DNA and deoxyribonucleotides, we hoped to gain further insight into the factors responsible for deoxyguanosine adduct formation by 5-methylchrysene dihydrodiol epoxide (5-MCDE) compared to 5, 6-dimethylchrysene dihydrodiol epoxide (5,6-DMCDE). The adduct yields in deoxyribonucleotide reactions of 5,9-DMCDE were slightly higher than those from 5-MCDE. However, the reaction yields of 5, 9-DMCDE with DNA were lower than those with 5-MCDE in most cases, particularly for the cis and trans deoxyadenosine adducts. It seems that the 9-methyl group of 5,9-DMCDE significantly influences adduct formation with the deoxyadenosine residue in DNA in contrast to the 6-methyl group of 5,6-DMCDE. The 9-methyl group sterically decreases deoxyadenosine adduct yields more in reaction with native DNA than denatured DNA, but it has little effect on deoxyribonucleotide reactions. Adduct formation with deoxyguanosine residues in DNA by all three dihydrodiol epoxides correlate with their respective tumorigenic and mutagenic activities. JF - Chemico-biological interactions AU - Szeliga, J AU - Amin, S AD - Chemistry of Carcinogenesis Laboratory, NCI-Frederick Cancer Research and Development Center, Building 538, Room 114, PO Box B, 21702, Frederick, MD, USA. Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 159 EP - 172 VL - 128 IS - 3 SN - 0009-2797, 0009-2797 KW - Carcinogens KW - 0 KW - Chrysenes KW - DNA Adducts KW - Deoxyadenosines KW - Deoxyribonucleotides KW - Mutagens KW - 1,2-dihydro-5,9-dimethyl-3,4-epoxy-1,2,3,4-tetrahydrochrysene KW - 139493-54-2 KW - 1,2-dihydroxy-epoxy-1,2,3,4-tetrahydro-5-methylchrysene KW - 81851-68-5 KW - DNA KW - 9007-49-2 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Molecular Structure KW - Animals KW - Stereoisomerism KW - Nucleic Acid Denaturation KW - DNA Adducts -- chemistry KW - Spectrophotometry, Ultraviolet KW - Thymus Gland -- chemistry KW - Circular Dichroism KW - Deoxyadenosines -- chemistry KW - Deoxyguanosine -- chemistry KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Cattle KW - Mutagens -- chemistry KW - Carcinogens -- chemistry KW - Deoxyribonucleotides -- chemistry KW - DNA -- chemistry KW - Chrysenes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72394231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Quantitative+reactions+of+anti+5%2C9-dimethylchrysene+dihydrodiol+epoxide+with+DNA+and+deoxyribonucleotides.&rft.au=Szeliga%2C+J%3BAmin%2C+S&rft.aulast=Szeliga&rft.aufirst=J&rft.date=2000-11-01&rft.volume=128&rft.issue=3&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels. AN - 72379646; 11055992 AB - The gating modifier toxins are a large family of protein toxins that modify either activation or inactivation of voltage-gated ion channels. omega-Aga-IVA is a gating modifier toxin from spider venom that inhibits voltage-gated Ca(2+) channels by shifting activation to more depolarized voltages. We identified two Glu residues near the COOH-terminal edge of S3 in the alpha(1A) Ca(2+) channel (one in repeat I and the other in repeat IV) that align with Glu residues previously implicated in forming the binding sites for gating modifier toxins on K(+) and Na(+) channels. We found that mutation of the Glu residue in repeat I of the Ca(2+) channel had no significant effect on inhibition by omega-Aga-IVA, whereas the equivalent mutation of the Glu in repeat IV disrupted inhibition by the toxin. These results suggest that the COOH-terminal end of S3 within repeat IV contributes to forming a receptor for omega-Aga-IVA. The strong predictive value of previous mapping studies for K(+) and Na(+) channel toxins argues for a conserved binding motif for gating modifier toxins within the voltage-sensing domains of voltage-gated ion channels. JF - The Journal of general physiology AU - Winterfield, J R AU - Swartz, K J AD - Molecular Physiology and Biophysics Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 637 EP - 644 VL - 116 IS - 5 SN - 0022-1295, 0022-1295 KW - Calcium Channel Blockers KW - 0 KW - Calcium Channels KW - DNA, Complementary KW - Spider Venoms KW - omega-Agatoxin IVA KW - Glutamine KW - 0RH81L854J KW - Index Medicus KW - Rats KW - Mutagenesis, Site-Directed KW - Animals KW - DNA, Complementary -- genetics KW - Glutamine -- metabolism KW - Muscle, Skeletal -- physiology KW - Point Mutation KW - Rabbits KW - Brain -- physiology KW - Binding Sites KW - Ion Channel Gating -- physiology KW - Calcium Channels -- physiology KW - Calcium Channel Blockers -- pharmacology KW - omega-Agatoxin IVA -- pharmacology KW - Calcium Channels -- drug effects KW - Spider Venoms -- pharmacology KW - Ion Channel Gating -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72379646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+physiology&rft.atitle=A+hot+spot+for+the+interaction+of+gating+modifier+toxins+with+voltage-dependent+ion+channels.&rft.au=Winterfield%2C+J+R%3BSwartz%2C+K+J&rft.aulast=Winterfield&rft.aufirst=J&rft.date=2000-11-01&rft.volume=116&rft.issue=5&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+physiology&rft.issn=00221295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann N Y Acad Sci. 1986;479:113-32 [2433986] Biophys J. 1999 Aug;77(2):747-57 [10423423] Pflugers Arch. 1987 Aug;409(4-5):381-93 [2442707] Science. 1988 Sep 23;241(4873):1661-4 [2458626] Proteins. 1989;6(4):357-71 [2576133] Nature. 1991 Apr 4;350(6317):398-402 [1849233] FEBS Lett. 1991 Oct 21;291(2):253-8 [1657644] J Biol Chem. 1991 Nov 15;266(32):21943-7 [1718988] Nature. 1992 Feb 27;355(6363):827-9 [1311418] Toxicon. 1991;29(9):1051-84 [1686683] Neuron. 1992 Jul;9(1):85-95 [1321648] Mol Pharmacol. 1993 Aug;44(2):451-60 [8394998] Biochemistry. 1993 Dec 7;32(48):13123-9 [8241166] J Biol Chem. 1994 Jan 28;269(4):2574-80 [8300586] Biochemistry. 1994 Sep 27;33(38):11420-5 [7918355] J Biol Chem. 1995 Jan 20;270(3):1123-9 [7836370] J Biomol NMR. 1995 Feb;5(2):122-32 [7703698] J Mol Biol. 1995 Apr 28;248(2):449-58 [7739052] Neuron. 1995 Jul;15(1):5-10 [7542463] J Mol Biol. 1995 Jul 28;250(5):659-71 [7623383] Structure. 1995 Aug 15;3(8):791-803 [7582896] J Gen Physiol. 1995 Oct;106(4):601-16 [8576699] J Gen Physiol. 1995 Oct;106(4):617-40 [8576700] J Biol Chem. 1996 Jul 5;271(27):15950-62 [8663157] J Bioenerg Biomembr. 1996 Jun;28(3):219-30 [8807398] Biophys J. 1997 May;72(5):2117-28 [9129813] Neuron. 1997 Apr;18(4):665-73 [9136774] Neuron. 1997 Apr;18(4):675-82 [9136775] J Gen Physiol. 2000 Jan;115(1):33-50 [10613917] J Gen Physiol. 2000 Jan;115(1):51-8 [10613918] J Mol Biol. 2000 Mar 31;297(3):771-80 [10731427] Neuron. 2000 Apr;26(1):13-25 [10798388] J Gen Physiol. 2000 Jun;115(6):673-84 [10828242] J Physiol. 1975 Jan;244(2):511-34 [1079869] J Gen Physiol. 1979 Sep;74(3):375-91 [479827] Mol Pharmacol. 1983 Mar;23(2):519-33 [6300654] J Gen Physiol. 1986 Sep;88(3):413-35 [2428923] Adv Cytopharmacol. 1979;3:345-52 [474301] Mol Pharmacol. 1997 Dec;52(6):1095-104 [9415720] Science. 1998 Apr 3;280(5360):69-77 [9525859] Science. 1998 Apr 3;280(5360):106-9 [9525854] Neuron. 1998 Mar;20(3):371-80 [9539115] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8585-9 [9671721] Neuron. 1998 Oct;21(4):919-31 [9808476] Biophys J. 1999 Mar;76(3):1384-400 [10049321] J Gen Physiol. 1999 Mar;113(3):415-23 [10051517] Nat Neurosci. 1998 Dec;1(8):668-74 [10196582] Nat Neurosci. 1999 May;2(5):407-15 [10321243] J Gen Physiol. 1987 Feb;89(2):253-74 [2435840] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of a doxorubicin-containing regimen in relapsed and resistant lymphomas: an 8-year follow-up study of EPOCH. AN - 72378789; 11054436 AB - Curative up-front regimens for non-Hodgkin's lymphomas contain doxorubicin, vincristine, and cyclophosphamide, whereas salvage regimens generally contain non-cross-resistant agents. We hypothesized that up-front agents may be highly effective for salvage and developed an infusional regimen based on in vitro evidence of increased efficacy. A prospective phase II study of etoposide, vincristine, and doxorubicin over 96 hours with bolus cyclophosphamide and oral prednisone (EPOCH) was performed in 131 patients with relapsed or resistant lymphoma. Seventy-nine percent of patients had aggressive histologies, 46% were considered high risk by the International Prognostic Index, and 34% had resistant disease. Eighty-eight percent of patients had received at least four of the agents in EPOCH, and 94% had received doxorubicin. In 125 assessable patients, 29 (24%) achieved complete responses and 60 (50%) achieved partial responses. Among 42 patients with resistant disease, 57% responded, and in 28 patients with relapsed aggressive de novo lymphomas, 89% responded with 54% complete responses. With a median follow-up of 76 months, the overall and event-free survivals (EFS) were 17.5 and 7 months, respectively. In 33 patients with sensitive aggressive disease who did not receive stem-cell transplantation, EFS was 19% at 36 months. Toxicity was primarily hematologic, with an 18% incidence of febrile neutropenia. No clinically significant cardiac toxicity was observed, despite no maximum cumulative doxorubicin dose. EPOCH is highly effective in patients who had previously received most/all of the same drugs and produces durable remissions in curable subtypes. Salvage regimens need not contain non-cross-resistant agents, and infusional schedules may partially reverse drug resistance and reduce toxicity. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Gutierrez, M AU - Chabner, B A AU - Pearson, D AU - Steinberg, S M AU - Jaffe, E S AU - Cheson, B D AU - Fojo, A AU - Wilson, W H AD - Division of Clinical Sciences, National Cancer Institute, Bethesda, MD, USA. Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 3633 EP - 3642 VL - 18 IS - 21 SN - 0732-183X, 0732-183X KW - Vincristine KW - 5J49Q6B70F KW - Etoposide KW - 6PLQ3CP4P3 KW - Doxorubicin KW - 80168379AG KW - Cyclophosphamide KW - 8N3DW7272P KW - Prednisone KW - VB0R961HZT KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Disease-Free Survival KW - Vincristine -- adverse effects KW - Humans KW - Salvage Therapy KW - Aged KW - Prednisone -- adverse effects KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Male KW - Prednisone -- administration & dosage KW - Survival Analysis KW - Doxorubicin -- adverse effects KW - Dose-Response Relationship, Drug KW - Vincristine -- administration & dosage KW - Doxorubicin -- administration & dosage KW - Cyclophosphamide -- adverse effects KW - Prospective Studies KW - Etoposide -- administration & dosage KW - Etoposide -- adverse effects KW - Cardiomyopathies -- chemically induced KW - Follow-Up Studies KW - Middle Aged KW - Stroke Volume -- drug effects KW - Female KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72378789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Role+of+a+doxorubicin-containing+regimen+in+relapsed+and+resistant+lymphomas%3A+an+8-year+follow-up+study+of+EPOCH.&rft.au=Gutierrez%2C+M%3BChabner%2C+B+A%3BPearson%2C+D%3BSteinberg%2C+S+M%3BJaffe%2C+E+S%3BCheson%2C+B+D%3BFojo%2C+A%3BWilson%2C+W+H&rft.aulast=Gutierrez&rft.aufirst=M&rft.date=2000-11-01&rft.volume=18&rft.issue=21&rft.spage=3633&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-30 N1 - Date created - 2000-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conditioning regimens for allogeneic stem cell transplants. AN - 72372031; 11055505 AB - In addition to providing cytoreduction at myeloablative dose intensity, conditioning regimens for allogeneic transplantation are designed to immunosuppress the recipient to permit donor lymphohematopoietic engraftment and thereby establish a graft-versus-malignancy effect. Increased confidence in the potency of this allogeneic graft-versus-malignancy effect, together with the need to reduce dose intensity to make transplantation safer and more widely applicable in older patients, has led to a conceptual revolution in conditioning regimen design. Novel nonmyeloablative transplant conditioning treatments have low regimen-related toxicity and low transplant-related mortality. The transplants confer a graft-versus-malignancy effect in myeloid and lymphoid malignancies and in metastatic renal cell cancer. Future prospects are for low toxicity conditioning regimens combined with specific antileukemia or antitumor intensification with radioconjugated or unmodified antibodies and the application of highly immunosuppressive but low toxicity conditioning regimens for mismatched transplants. JF - Current opinion in hematology AU - Barrett, A J AD - Allogeneic Stem Cell Transplant Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institute of Health, Bethesda, Maryland 20892, USA. barrettj@nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 339 EP - 342 VL - 7 IS - 6 SN - 1065-6251, 1065-6251 KW - Index Medicus KW - Graft vs Tumor Effect KW - Histocompatibility Testing -- adverse effects KW - Humans KW - Transplantation, Homologous -- methods KW - Graft vs Host Disease -- prevention & control KW - Hematopoietic Stem Cell Transplantation -- methods KW - Transplantation Conditioning -- adverse effects KW - Transplantation Conditioning -- methods KW - Transplantation Conditioning -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72372031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+hematology&rft.atitle=Conditioning+regimens+for+allogeneic+stem+cell+transplants.&rft.au=Barrett%2C+A+J&rft.aulast=Barrett&rft.aufirst=A&rft.date=2000-11-01&rft.volume=7&rft.issue=6&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+hematology&rft.issn=10656251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-04-05 N1 - Date created - 2001-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Advances in interleukin 2 receptor targeted treatment. AN - 72370797; 11053100 AB - T cell activation and cellular immune responses are modulated by interleukin 2 (IL2) through binding to its corresponding cell surface receptor. Three forms of the receptor are recognised based on IL2 binding affinity. The high affinity receptor is a heterotrimer composed of alpha, beta, and gamma(c)-polypeptide chains. The 55 kDa alpha-chain also known as the Tac (T cell activation) antigen or CD-25 is a unique subunit of the high affinity IL2 receptor (IL2Ralpha). Resting T cells express few IL2Ralpha, however, when activated, the expression of ILR2alpha rapidly increases. The IL2Ralpha is shed from the cell surface and is measurable in the serum as a 45 kDa soluble form (s-Tac or s-IL2Ralpha). Serum concentrations of s-Tac can be used as a surrogate marker for T cell activation and IL2Ralpha expression. IL2Ralpha is over expressed by T cells in a number of autoimmune diseases, allograft rejection and a variety of lymphoid neoplasms. IL2 induced proliferation of T cells can be inhibited by the murine monoclonal antibody (anti-Tac) directed against the alpha-chain of the IL2R. Through molecular engineering, murine anti-Tac has been humanised reducing its immunogenicity without changing its specificity. Humanised anti-Tac (HAT) has been shown to reduce the incidence of renal and cardiac allograft rejection as well as decrease the severity of graft versus host disease in patients undergoing HLA matched allogeneic bone marrow transplantation. IL2Ralpha targeted treatment with radioimmunoconjugates of anti-Tac and immunotoxins has shown promise in the treatment of CD25 expressing lymphomas. JF - Annals of the rheumatic diseases AU - Morris, J C AU - Waldmann, T A AD - Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, NIH, Bldg 10, Rm 4N115, 10 Center Drive, Bethesda, MD 20892-1374, USA. jmorris@mail.nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - i109 EP - i114 VL - 59 Suppl 1 SN - 0003-4967, 0003-4967 KW - Antibodies, Monoclonal KW - 0 KW - Receptors, Interleukin-2 KW - Index Medicus KW - Humans KW - Autoimmune Diseases -- therapy KW - Receptors, Interleukin-2 -- antagonists & inhibitors KW - Neoplasms -- therapy KW - Graft Rejection -- prevention & control KW - Receptors, Interleukin-2 -- immunology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72370797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+rheumatic+diseases&rft.atitle=Advances+in+interleukin+2+receptor+targeted+treatment.&rft.au=Morris%2C+J+C%3BWaldmann%2C+T+A&rft.aulast=Morris&rft.aufirst=J&rft.date=2000-11-01&rft.volume=59+Suppl+1&rft.issue=&rft.spage=i109&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+rheumatic+diseases&rft.issn=00034967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-21 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 1994 Jul 14;370(6485):151-3 [8022485] Nature. 1994 Jul 14;370(6485):153-7 [8022486] Blood. 1994 Aug 15;84(4):1320-7 [8049447] Clin Immunol Immunopathol. 1994 Dec;73(3):296-304 [7661913] J Rheumatol. 1994 Oct;21(10):1820-4 [7837144] J Rheumatol. 1994 Dec;21(12):2359-63 [7699643] N Engl J Med. 1995 Jun 29;332(26):1744-8 [7760890] J Natl Cancer Inst. 1995 Jul 5;87(13):1009-14 [7629870] Clin Rheumatol. 1995 May;14(3):293-300 [7641505] Blood. 1995 Dec 1;86(11):4063-75 [7492762] Transfus Sci. 1994 Sep;15(3):189-96 [10155540] Bone Marrow Transplant. 1995 Oct;16(4):577-81 [8528175] J Biol Chem. 1996 May 3;271(18):10453-60 [8631840] Bone Marrow Transplant. 1996 Feb;17(2):185-90 [8640164] J Exp Med. 1996 Apr 1;183(4):1587-602 [8666917] J Clin Pathol. 1996 Aug;49(8):660-3 [8881918] Stem Cells. 1996 Sep;14(5):473-89 [8888489] West Indian Med J. 1996 Dec;45(4):107-9 [9033228] Br J Rheumatol. 1997 Feb;36(2):194-7 [9133928] J Rheumatol. 1991 Jun;18(6):831-6 [1680190] J Immunol Methods. 1991 Aug 28;142(1):61-72 [1717594] Science. 1992 Jul 17;257(5068):379-82 [1631559] Autoimmunity. 1992;13(4):303-9 [1472640] Ann Rheum Dis. 1993 Jan;52(1):58-60 [8093995] Int J Cancer. 1993 May 8;54(2):255-60 [8486428] Blood. 2000 Jan 1;95(1):83-9 [10607689] Drugs. 1999 Dec;58(6):1029-42 [10651389] Transplantation. 2000 Jan 27;69(2):307-11 [10670644] N Engl J Med. 2000 Mar 2;342(9):613-9 [10699160] J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] Science. 1976 Sep 10;193(4257):1007-8 [181845] Blood. 1977 Sep;50(3):481-92 [301762] Nature. 1977 Jul 14;268(5616):154-6 [145543] Cell. 1978 Sep;15(1):245-50 [699044] J Immunol. 1981 Apr;126(4):1398-403 [6451645] Proc Natl Acad Sci U S A. 1981 Mar;78(3):1887-91 [6262827] J Exp Med. 1981 Nov 1;154(5):1455-74 [6975347] Nature. 1983 Mar 24-30;302(5906):305-10 [6403867] Lancet. 1984 Mar 3;1(8375):472-6 [6142207] J Clin Invest. 1984 Jun;73(6):1711-8 [6327770] Nature. 1984 Oct 18-24;311(5987):626-31 [6090948] Hybridoma. 1985 Summer;4(2):91-102 [2408992] Science. 1986 May 9;232(4751):727-32 [3008337] Science. 1986 Nov 14;234(4778):859-63 [3095922] Proc Natl Acad Sci U S A. 1986 Dec;83(24):9694-8 [3099289] Clin Exp Immunol. 1986 Oct;66(1):126-31 [3100116] Cancer Res. 1987 Apr 15;47(8):2188-95 [3030546] J Immunol. 1987 Aug 1;139(3):855-62 [3036946] Science. 1988 May 27;240(4856):1169-76 [3131876] J Clin Oncol. 1988 Jul;6(7):1088-97 [2899140] Arthritis Rheum. 1988 Jul;31(7):844-9 [3134896] Arthritis Rheum. 1988 Nov;31(11):1358-64 [3263865] Proc Natl Acad Sci U S A. 1989 Mar;86(6):1982-6 [2467293] Proc Natl Acad Sci U S A. 1989 Jun;86(11):4220-4 [2726771] J Autoimmun. 1988 Aug;1(4):353-61 [3266993] Pathol Annu. 1989;24 Pt 2:149-65 [2671880] Proc Natl Acad Sci U S A. 1989 Dec;86(24):10029-33 [2513570] Annu Rev Immunol. 1997;15:15-37 [9143680] N Engl J Med. 1998 Jan 15;338(3):161-5 [9428817] Bone Marrow Transplant. 1998 Jan;21(1):29-32 [9486491] Leuk Lymphoma. 1997 Dec;28(1-2):159-69 [9498715] Bone Marrow Transplant. 1998 Apr;21(8):769-73 [9603399] J Am Acad Dermatol. 1998 Jul;39(1):63-73 [9674399] Bone Marrow Transplant. 1998 Jun;21 Suppl 3:S13-5 [9712485] Clin Rheumatol. 1998;17(4):311-7 [9776115] Curr Opin Immunol. 1998 Oct;10(5):507-12 [9794841] Transplantation. 1999 Jan 15;67(1):110-5 [9921806] Bone Marrow Transplant. 1999 Jan;23(2):137-44 [10197798] Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7462-6 [10377437] Pharmacotherapy. 1999 Oct;19(10):1127-37 [10512062] J Biol Chem. 1991 Feb 15;266(5):2681-4 [1993646] N Engl J Med. 1991 Mar 7;324(10):667-74 [1994250] Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2663-7 [2011577] Annu Rev Med. 1991;42:189-97 [2035965] Transplantation. 1991 Jun;51(6):1197-203 [2048196] Bone Marrow Transplant. 1991;7 Suppl 2:117-9 [1715225] Cancer Res. 1990 Mar 1;50(5):1495-502 [2406013] J Biol Chem. 1990 Jul 15;265(20):11885-9 [2195027] Arthritis Rheum. 1990 Aug;33(8):1145-8 [2390120] Ann Intern Med. 1990 Oct 15;113(8):619-27 [2205142] Bone Marrow Transplant. 1990 Aug;6(2):97-101 [2207458] J Immunol. 1993 Jul 15;151(2):1075-85 [8335891] Blood. 1993 Sep 15;82(6):1701-12 [8400227] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Theoretical and observed subtypes of DSM-IV alcohol abuse and dependence in a general population sample. AN - 72363041; 11053763 AB - The purpose of this study was to quantify the degree of heterogeneity of the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) alcohol abuse and dependence categories by comparing the number of theoretically predicted subtypes of each category with those observed in a nationally representative sample of the US general population. Among respondents classified with a past year diagnosis of abuse, only 11 (47.8%) of the 23 theoretically predicted subtypes of abuse were observed, while 53 (53.5%) of the 99 theoretically predicted subtypes of dependence were observed in this general population sample. Approximately 90% of the respondents classified with abuse could be represented by three subtypes of abuse and 70% of the respondents with current diagnoses of dependence could be characterized by six subtypes of dependence, indicating the relative homogeneity of both diagnostic categories. Sociodemographic differentials were also observed including the reduction in the number of observed subtypes of abuse and dependence with age as well as the larger numbers of subtypes associated with males and whites relative to females and blacks, respectively. Implications of these results are discussed in terms of increased physical morbidity and disruption of family life as persons with alcohol use disorders age, the potential role of physiological and impaired control over drinking indicators of dependence as critical features of the disorder, and the future need to examine the conceptual basis of the abuse category and to conduct longitudinal epidemiological research. JF - Drug and alcohol dependence AU - Grant, B F AD - Division of Biometry and Epidemiology, Suite 514, National Institute on Alcohol Abuse and Alcoholism, MSC-7003, 6000 Executive Boulevard, Bethesda, MD 20892-7003, USA. Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 287 EP - 293 VL - 60 IS - 3 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Male KW - Female KW - Prevalence KW - Psychiatric Status Rating Scales KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Population Surveillance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72363041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Theoretical+and+observed+subtypes+of+DSM-IV+alcohol+abuse+and+dependence+in+a+general+population+sample.&rft.au=Grant%2C+B+F&rft.aulast=Grant&rft.aufirst=B&rft.date=2000-11-01&rft.volume=60&rft.issue=3&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-21 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substance P differentially stimulates IL-8 synthesis in human corneal epithelial cells. AN - 72361317; 11053288 AB - To determine whether substance P (SP), a neuropeptide with proinflammatory properties, specifically interacts with human corneal epithelial cells to stimulate synthesis of the chemokines interleukin (IL)-8, monocyte chemo-attractant protein (MCP)-1, and regulated on activation normal T-cell expressed and secreted (RANTES) protein. Primary cultures of human corneal epithelial cells were established from human corneas. Expression of the SP receptor neurokinin (NK)-1 was determined by both the reverse transcription-polymerase chain reaction (RT-PCR) and radiolabeled saturation binding experiments. Synthesis of chemokine-specific RNA in cells stimulated with SP was analyzed by RT-PCR, and quantitation of chemokine protein synthesis was achieved by enzyme-linked immunosorbent assay. Human corneal epithelial cells expressed NK-1 mRNA and bound SP with a K:(d) characteristic of NK-1. Exposure of cells to SP had no effect on IL-8-specific mRNA synthesis, whereas it increased the half-life of IL-8 transcripts by more than twofold, resulting in significant enhancement of IL-8 synthesis. The capacity of SP to bind to corneal epithelial cells and to induce IL-8 synthesis was abrogated in the presence of a specific NK-1 receptor antagonist. In contrast to IL-8, exposure of cells to SP did not stimulate synthesis of MCP-1 or RANTES. The results suggest that human corneal cells express NK-1 receptors that specifically bind SP and induce IL-8 synthesis by stabilizing the chemokine's transcripts. JF - Investigative ophthalmology & visual science AU - Tran, M T AU - Lausch, R N AU - Oakes, J E AD - Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 3871 EP - 3877 VL - 41 IS - 12 SN - 0146-0404, 0146-0404 KW - Chemokine CCL2 KW - 0 KW - Chemokine CCL5 KW - DNA Primers KW - Interleukin-8 KW - Neurokinin-1 Receptor Antagonists KW - RNA, Messenger KW - Receptors, Neurokinin-1 KW - Substance P KW - 33507-63-0 KW - spantide KW - 91224-37-2 KW - Index Medicus KW - Chemokine CCL5 -- biosynthesis KW - Gene Expression -- drug effects KW - Chemokine CCL2 -- genetics KW - Receptors, Neurokinin-1 -- biosynthesis KW - Receptors, Neurokinin-1 -- genetics KW - Humans KW - Reverse Transcriptase Polymerase Chain Reaction KW - Chemokine CCL5 -- genetics KW - RNA, Messenger -- biosynthesis KW - Half-Life KW - Cells, Cultured KW - Chemokine CCL2 -- biosynthesis KW - Enzyme-Linked Immunosorbent Assay KW - DNA Primers -- chemistry KW - Epithelium, Corneal -- metabolism KW - Substance P -- pharmacology KW - Interleukin-8 -- biosynthesis KW - Epithelium, Corneal -- drug effects KW - Substance P -- antagonists & inhibitors KW - Interleukin-8 -- genetics KW - Epithelium, Corneal -- cytology KW - Substance P -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72361317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Substance+P+differentially+stimulates+IL-8+synthesis+in+human+corneal+epithelial+cells.&rft.au=Tran%2C+M+T%3BLausch%2C+R+N%3BOakes%2C+J+E&rft.aulast=Tran&rft.aufirst=M&rft.date=2000-11-01&rft.volume=41&rft.issue=12&rft.spage=3871&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-14 N1 - Date created - 2000-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression and characterization of recombinant human-derived Pneumocystis carinii dihydrofolate reductase. AN - 72343527; 11036028 AB - Dihydrofolate reductase (DHFR) is the target of trimethoprim (TMP), which has been widely used in combination with sulfa drugs for treatment and prophylaxis of Pneumocystis carinii pneumonia. While the rat-derived P. carinii DHFR has been well characterized, kinetic studies of human-derived P. carinii DHFR, which differs from rat-derived P. carinii DHFR by 38% in amino acid sequence, have not been reported to date. Here we report on the expression and kinetic characterization of the recombinant human-derived P. carinii DHFR. The 618-bp coding sequence of the human-derived P. carinii DHFR gene was expressed in Escherichia coli. As determined by sodium dodecyl sulfate-polyacrylamide gel eletrophoresis, the purified enzyme had a molecular mass of 25 kDa, consistent with that predicted from the DNA sequence. Kinetic analysis showed that the K(m) values for dihydrofolate and NADPH were 2.7 +/- 0.3 and 14.0 +/- 4.3 microM, respectively, which are similar to those reported for rat-derived P. carinii DHFR. Inhibition studies revealed that both TMP and pyrimethamine were poor inhibitors of human-derived P. carinii DHFR, with K(i) values of 0.28 +/- 0.08 and 0.065 +/- 0.005 microM, respectively, while trimetrexate and methotrexate were potent inhibitors, with K(i) values of 0.23 +/- 0.03 and 0.016 +/- 0.004 nM, respectively. The availability of purified recombinant enzyme in large quantities should facilitate the identification of antifolate inhibitors with greater potency and higher selectivity for human-derived P. carinii DHFR. JF - Antimicrobial agents and chemotherapy AU - Ma, L AU - Kovacs, J A AD - Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 3092 EP - 3096 VL - 44 IS - 11 SN - 0066-4804, 0066-4804 KW - Folic Acid Antagonists KW - 0 KW - Recombinant Proteins KW - Tetrahydrofolate Dehydrogenase KW - EC 1.5.1.3 KW - Index Medicus KW - Recombinant Proteins -- isolation & purification KW - Recombinant Proteins -- drug effects KW - Polymerase Chain Reaction KW - Folic Acid Antagonists -- pharmacology KW - Transfection KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Humans KW - Binding, Competitive KW - Escherichia coli KW - Inhibitory Concentration 50 KW - Catalysis KW - Pneumocystis -- metabolism KW - Pneumocystis -- enzymology KW - Pneumocystis -- genetics KW - Tetrahydrofolate Dehydrogenase -- isolation & purification KW - Pneumocystis -- drug effects KW - Tetrahydrofolate Dehydrogenase -- drug effects KW - Tetrahydrofolate Dehydrogenase -- metabolism KW - Tetrahydrofolate Dehydrogenase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72343527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Expression+and+characterization+of+recombinant+human-derived+Pneumocystis+carinii+dihydrofolate+reductase.&rft.au=Ma%2C+L%3BKovacs%2C+J+A&rft.aulast=Ma&rft.aufirst=L&rft.date=2000-11-01&rft.volume=44&rft.issue=11&rft.spage=3092&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Biochem Biophys. 1993 Sep;305(2):499-508 [8373187] Protein Expr Purif. 1993 Feb;4(1):16-23 [8425104] AIDS. 1998 May 28;12(8):873-8 [9631140] Lancet. 1999 Oct 16;354(9187):1347-51 [10533864] J Infect Dis. 1999 Dec;180(6):1969-78 [10558954] Mol Biochem Parasitol. 1999 Oct 25;104(1):55-66 [10589981] J Biol Chem. 2000 Apr 7;275(14):10702-8 [10744768] Anal Biochem. 1967 Nov;21(2):178-89 [4384177] Biochem J. 1973 Sep;135(1):101-7 [4204669] Anal Biochem. 1976 May 7;72:248-54 [942051] Antimicrob Agents Chemother. 1978 Jun;13(6):975-8 [307941] Biochemistry. 1981 Mar 31;20(7):1710-6 [7013798] J Exp Med. 1987 Mar 1;165(3):926-31 [2950200] N Engl J Med. 1987 Oct 15;317(16):978-85 [2958710] Antimicrob Agents Chemother. 1987 Sep;31(9):1323-7 [2445281] Antimicrob Agents Chemother. 1988 Jan;32(1):96-103 [3258144] J Infect Dis. 1988 Jul;158(1):254-9 [2969023] J Infect Dis. 1989 Aug;160(2):312-20 [2527275] Proc Natl Acad Sci U S A. 1989 Nov;86(22):8625-9 [2682653] Exp Parasitol. 1990 Jul;71(1):60-8 [2354716] Biochem Cell Biol. 1990 Sep;68(9):1075-82 [2124130] Antimicrob Agents Chemother. 1991 Jul;35(7):1348-55 [1929292] Protein Expr Purif. 1991 Oct-Dec;2(5-6):313-6 [1821803] Adv Enzymol Relat Areas Mol Biol. 1995;70:23-102 [8638484] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic analysis of azole resistance in the Darlington strain of Candida albicans. AN - 72341830; 11036010 AB - High-level azole resistance in the Darlington strain of Candida albicans was investigated by gene replacement in C. albicans and expression in Saccharomyces cerevisiae. We sequenced the ERG11 gene, which encodes the sterol C(14)alpha-demethylase, from our copy of the Darlington strain. Both alleles contained the histidine for tyrosine substitution at position 132 (Y132H) reported in Darlington by others, but we also found a threonine-for-isoleucine substitution (I471T) not previously reported in the C. albicans ERG11. The encoded I471T change in amino acids conferred azole resistance when overexpressed alone and increased azole resistance when added to the Y132H amino acid sequence in an S. cerevisiae expression system. Replacement of one copy of ERG11 in an azole-susceptible strain of C. albicans with a single copy of the Darlington ERG11 resulted in expression of the integrated copy and a modest increase in azole resistance. The profound azole resistance of the Darlington strain is the result of multiple mutations. JF - Antimicrobial agents and chemotherapy AU - Kakeya, H AU - Miyazaki, Y AU - Miyazaki, H AU - Nyswaner, K AU - Grimberg, B AU - Bennett, J E AD - Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 2985 EP - 2990 VL - 44 IS - 11 SN - 0066-4804, 0066-4804 KW - Antifungal Agents KW - 0 KW - Fluconazole KW - 8VZV102JFY KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Oxidoreductases KW - EC 1.- KW - Sterol 14-Demethylase KW - EC 1.14.13.70 KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - Mutagenesis, Site-Directed KW - Transfection KW - Drug Resistance, Microbial -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Microbial Sensitivity Tests KW - Amino Acid Substitution KW - Chromosomes, Fungal -- genetics KW - Candida albicans -- genetics KW - Oxidoreductases -- genetics KW - Antifungal Agents -- pharmacology KW - Cytochrome P-450 Enzyme System -- genetics KW - Fluconazole -- pharmacology KW - Candida albicans -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72341830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Genetic+analysis+of+azole+resistance+in+the+Darlington+strain+of+Candida+albicans.&rft.au=Kakeya%2C+H%3BMiyazaki%2C+Y%3BMiyazaki%2C+H%3BNyswaner%2C+K%3BGrimberg%2C+B%3BBennett%2C+J+E&rft.aulast=Kakeya&rft.aufirst=H&rft.date=2000-11-01&rft.volume=44&rft.issue=11&rft.spage=2985&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-04 N1 - Date created - 2000-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Microbiology. 1999 Oct;145 ( Pt 10):2701-13 [10537192] Gene. 1999 Aug 5;236(1):43-51 [10433965] Lancet. 1983 Mar 19;1(8325):642-3 [6131314] J Med Vet Mycol. 1987 Oct;25(5):329-33 [3323450] Nucleic Acids Res. 1989 Jan 25;17(2):804 [2644625] Biochem Soc Trans. 1990 Feb;18(1):56-9 [2185088] J Appl Bacteriol. 1990 Nov;69(5):692-6 [2276986] J Clin Microbiol. 1991 Jul;29(7):1364-7 [1679438] Infect Immun. 1992 Mar;60(3):1101-8 [1541525] Nucleic Acids Res. 1992 Mar 25;20(6):1425 [1561104] Biotechniques. 1993 Apr;14(4):538-40 [8476589] Genetics. 1993 Jul;134(3):717-28 [8349105] Science. 1994 Apr 22;264(5158):566-9 [7909170] Mol Cell Biol. 1994 Jul;14(7):4653-61 [8007969] J Mol Evol. 1996 Feb;42(2):321-2 [8919884] Antimicrob Agents Chemother. 1996 Dec;40(12):2835-41 [9124851] J Biol Chem. 1997 Feb 28;272(9):5682-8 [9038178] Antimicrob Agents Chemother. 1997 Jul;41(7):1482-7 [9210670] Antimicrob Agents Chemother. 1997 Jul;41(7):1488-94 [9210671] FEMS Microbiol Lett. 1997 Jun 15;151(2):263-8 [9228762] Antimicrob Agents Chemother. 1998 Feb;42(2):241-53 [9527767] Clin Microbiol Rev. 1998 Apr;11(2):382-402 [9564569] Antimicrob Agents Chemother. 1999 May;43(5):1163-9 [10223930] Microbiology. 1999 Oct;145 ( Pt 10):2715-25 [10537193] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elevated ceramide is downstream of altered calcium homeostasis in low serum-induced apoptosis. AN - 72334052; 11029312 AB - Two immortalized cell lines, sup (+) and sup (-), derived from mutagenized Syrian hamster embryo cells, were used to study the relationship and temporal order between calcium and ceramide signals during apoptosis. The early preneoplastic cells, termed sup (+), suppress tumorigenicity when hybridized with tumor cells, whereas later-stage sup (-) cells do not. In reduced serum conditions, sup (+) cells cease proliferating and undergo apoptosis; in contrast, sup (-) cells continue slow growth and undergo necrosis. In sup (+) cells, decreased endoplasmic reticulum (ER) calcium occurs 4 h after low serum treatment and precedes apoptosis. Significant elevations in ceramide are observed 16 h after reduced serum treatment of sup (+) cells but are not found in sup (-) cells. Inhibiting ER calcium depletion in low serum-treated sup (+) cells by treating with high levels of calcium prevents both ceramide generation and apoptosis. Conversely, inducing ER calcium depletion in sup (-) cells by treating with low serum plus thapsigargin results in elevated ceramide levels and apoptosis. Furthermore, C(6)-ceramide treatment induced apoptosis of sup (-) cells in low serum, a condition that does not normally cause apoptosis. C(6)-ceramide treatment did not induce apoptosis in either sup (+) or sup (-) cells in 10% serum but did cause G(2)/M arrest. These studies show that ceramide production is downstream of ER calcium release. JF - American journal of physiology. Cell physiology AU - Jayadev, S AU - Barrett, J C AU - Murphy, E AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - C1640 EP - C1647 VL - 279 IS - 5 SN - 0363-6143, 0363-6143 KW - Ceramides KW - 0 KW - Culture Media KW - Diglycerides KW - Enzyme Inhibitors KW - N-caproylsphingosine KW - 038753E78J KW - Thapsigargin KW - 67526-95-8 KW - Index Medicus KW - Thapsigargin -- pharmacology KW - Endoplasmic Reticulum -- metabolism KW - Animals KW - Mesocricetus KW - Enzyme Inhibitors -- pharmacology KW - Cells, Cultured -- drug effects KW - Cell Cycle -- drug effects KW - Diglycerides -- metabolism KW - Cricetinae KW - Signal Transduction -- physiology KW - Blood KW - Calcium Signaling -- physiology KW - Apoptosis -- physiology KW - Ceramides -- physiology KW - Ceramides -- pharmacology KW - Culture Media -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72334052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Cell+physiology&rft.atitle=Elevated+ceramide+is+downstream+of+altered+calcium+homeostasis+in+low+serum-induced+apoptosis.&rft.au=Jayadev%2C+S%3BBarrett%2C+J+C%3BMurphy%2C+E&rft.aulast=Jayadev&rft.aufirst=S&rft.date=2000-11-01&rft.volume=279&rft.issue=5&rft.spage=C1640&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Cell+physiology&rft.issn=03636143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-16 N1 - Date created - 2000-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intravenous cocaine decreases cardiac vagal tone, vagal index (derived in lorenz space), and heart period complexity (approximate entropy) in cocaine abusers. AN - 72329853; 11027921 AB - We assessed the effects of i.v. cocaine on parasympathetic and sympathetic nervous system activity, and on the complexity vs. regularity of changes in heart rate over time. Fourteen otherwise healthy men with histories of i.v. cocaine abuse received bolus injections of cocaine (20 mg or 40 mg) and placebo (saline) on different days. Cardiovascular measures derived from the electrocardiogram, including heart rate, Porges' vagal tone (respiratory sinus arrhythmia), the 0.10 Hz rhythm, Toichi's vagal index, Toichi's sympathetic index, and approximate entropy (ApEn), were measured continuously. As predicted, cocaine produced tachycardia, accompanied by pronounced decreases in response to 40 mg cocaine in two different vagal tone indexes that precisely mirrored the increases in heart rate. The measure of sympathetic (and vagal) neural influences on the heart (0.10 Hz wave) also decreased in response to cocaine. Converging evidence from Toichi's vagal index supported the conclusion that the tachycardia from cocaine was due to withdrawal of cardiac vagal tone. These findings, and evidence that cocaine decreased cardiovascular complexity, contradict the prevailing assumption that the mechanism by which cocaine produces tachycardia is sympathetic (beta-adrenergic). We discuss implications for cardiac arrhythmias associated with cocaine abuse and death due to overdose. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Newlin, D B AU - Wong, C J AU - Stapleton, J M AU - London, E D AD - National Institute on Drug Abuse, Baltimore, MD 21224, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 560 EP - 568 VL - 23 IS - 5 SN - 0893-133X, 0893-133X KW - Dopamine Uptake Inhibitors KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Hemodynamics -- drug effects KW - Injections, Intravenous KW - Humans KW - Adult KW - Time Factors KW - Male KW - Entropy KW - Electrocardiography -- drug effects KW - Heart Rate -- drug effects KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Cocaine-Related Disorders -- physiopathology KW - Heart -- drug effects KW - Vagus Nerve -- drug effects KW - Cocaine -- pharmacology KW - Cocaine -- administration & dosage KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72329853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Intravenous+cocaine+decreases+cardiac+vagal+tone%2C+vagal+index+%28derived+in+lorenz+space%29%2C+and+heart+period+complexity+%28approximate+entropy%29+in+cocaine+abusers.&rft.au=Newlin%2C+D+B%3BWong%2C+C+J%3BStapleton%2C+J+M%3BLondon%2C+E+D&rft.aulast=Newlin&rft.aufirst=D&rft.date=2000-11-01&rft.volume=23&rft.issue=5&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-21 N1 - Date created - 2000-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - PKC and ERK1/2 regulate amylase promoter activity during differentiation of a salivary gland cell line. AN - 72324439; 11025443 AB - The addition of transforming growth factor alpha (TGFalpha) to a human submandibular gland cell line (HSG) cultured on basement membrane extract Matrigel, synergistically activates the acinar cell-specific salivary amylase promoter. Signaling through beta1 integrins and increased phosphorylation of ERK1/2 are involved in the increased promoter activity. Phorbol-12-myristate-13-acetate (PMA) and thapsigargin increase amylase promoter activity, suggesting that phorbol ester and calcium-dependent protein kinase C (PKC) pathways are also involved. The combination of specific inhibitors of PKC and MEK1 inhibits the amylase promoter. Inhibitors of the calcium-dependent PKC isoforms alpha, beta, and gamma decrease the promoter activity; however, PKCbeta is not detectable in HSG cells. TGFalpha alters the cellular localization of PKCalpha but not -gamma, suggesting PKCalpha is involved in TGFalpha upregulation of the amylase promoter. Furthermore, rottlerin, a PKCdelta-specific inhibitor, increases the promoter activity, suggesting PKC isoforms differentially regulate the amylase promoter. In conclusion, beta1-integrin and TGFalpha signaling pathways regulate the amylase promoter activity in HSG cells. In response to Matrigel and TGFalpha, the activation of both PKCalpha and phosphorylation of ERK1/2 results in synergistic activation of the amylase promoter. Published 2000 Wiley-Liss, Inc. JF - Journal of cellular physiology AU - Jung, D W AU - Hecht, D AU - Ho, S W AU - O'Connell, B C AU - Kleinman, H K AU - Hoffman, M P AD - Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 215 EP - 225 VL - 185 IS - 2 SN - 0021-9541, 0021-9541 KW - Drug Combinations KW - 0 KW - Integrins KW - Isoenzymes KW - Laminin KW - Proteoglycans KW - Transforming Growth Factor alpha KW - matrigel KW - 119978-18-6 KW - Threonine KW - 2ZD004190S KW - Serine KW - 452VLY9402 KW - Collagen KW - 9007-34-5 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Mitogen-Activated Protein Kinases KW - MAP Kinase Kinase 1 KW - EC 2.7.12.2 KW - MAP2K1 protein, human KW - Mitogen-Activated Protein Kinase Kinases KW - Amylases KW - EC 3.2.1.- KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Threonine -- metabolism KW - Cell Adhesion -- physiology KW - Humans KW - Protein-Serine-Threonine Kinases -- antagonists & inhibitors KW - Serine -- metabolism KW - Calcium -- metabolism KW - Proteoglycans -- pharmacology KW - Phosphorylation KW - Cell Differentiation -- physiology KW - Isoenzymes -- physiology KW - Transforming Growth Factor alpha -- pharmacology KW - Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors KW - Collagen -- pharmacology KW - Intracellular Membranes -- metabolism KW - Drug Synergism KW - Laminin -- pharmacology KW - Cell Line KW - Integrins -- physiology KW - Promoter Regions, Genetic -- physiology KW - Promoter Regions, Genetic -- drug effects KW - Submandibular Gland -- cytology KW - Protein Kinase C -- physiology KW - Submandibular Gland -- physiology KW - Mitogen-Activated Protein Kinases -- physiology KW - Mitogen-Activated Protein Kinase 1 -- physiology KW - Amylases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72324439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=PKC+and+ERK1%2F2+regulate+amylase+promoter+activity+during+differentiation+of+a+salivary+gland+cell+line.&rft.au=Jung%2C+D+W%3BHecht%2C+D%3BHo%2C+S+W%3BO%27Connell%2C+B+C%3BKleinman%2C+H+K%3BHoffman%2C+M+P&rft.aulast=Jung&rft.aufirst=D&rft.date=2000-11-01&rft.volume=185&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-30 N1 - Date created - 2000-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation. AN - 72319458; 11023867 AB - Primordial follicles are formed perinatally in mammalian ovaries and at birth represent the lifetime complement of germ cells. With cyclic periodicity, cohorts enter into a growth phase that culminates in ovulation of mature eggs, but little is known about the regulatory cascades that govern these events. FIGalpha, a transcription factor implicated in postnatal oocyte-specific gene expression, is detected as early as embryonic day 13. Mouse lines lacking FIGalpha were established by targeted mutagenesis in embryonic stem cells. Although embryonic gonadogenesis appeared normal, primordial follicles were not formed at birth, and massive depletion of oocytes resulted in shrunken ovaries and female sterility. Fig(&agr;) (the gene for FIGalpha null males have normal fertility. The additional observation that null females do not express Zp1, Zp2 or Zp3 indicates that FIGalpha plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida required for fertilization and early embryonic survival. The persistence of FIGalpha in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. JF - Development (Cambridge, England) AU - Soyal, S M AU - Amleh, A AU - Dean, J AD - Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. ss278v@nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 4645 EP - 4654 VL - 127 IS - 21 SN - 0950-1991, 0950-1991 KW - Basic Helix-Loop-Helix Transcription Factors KW - 0 KW - DNA-Binding Proteins KW - Figla protein, mouse KW - Transcription Factors KW - Index Medicus KW - Animals KW - Aging KW - Gestational Age KW - Oocytes -- physiology KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Genomic Library KW - Pregnancy KW - Mice, Knockout KW - Mutagenesis, Site-Directed KW - Animals, Newborn KW - Helix-Loop-Helix Motifs KW - Embryonic and Fetal Development KW - Heterozygote KW - Crosses, Genetic KW - Female KW - Male KW - Ovarian Follicle -- physiology KW - Transcription Factors -- metabolism KW - DNA-Binding Proteins -- genetics KW - Ovarian Follicle -- embryology KW - Transcription Factors -- genetics KW - Gene Expression Regulation, Developmental KW - Ovarian Follicle -- growth & development KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72319458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development+%28Cambridge%2C+England%29&rft.atitle=FIGalpha%2C+a+germ+cell-specific+transcription+factor+required+for+ovarian+follicle+formation.&rft.au=Soyal%2C+S+M%3BAmleh%2C+A%3BDean%2C+J&rft.aulast=Soyal&rft.aufirst=S&rft.date=2000-11-01&rft.volume=127&rft.issue=21&rft.spage=4645&rft.isbn=&rft.btitle=&rft.title=Development+%28Cambridge%2C+England%29&rft.issn=09501991&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-22 N1 - Date created - 2000-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of behavioral sensitization to cocaine by NAALADase inhibition. AN - 72310096; 11018790 AB - Sensitization to cocaine has been attributed to alterations in excitatory amino acid and dopamine neurotransmission in the mesolimbic system. The present study sought to determine whether inhibition of NAALADase, an enzyme that cleaves glutamate from the endogenous neuropeptide, N-acetyl-aspartyl-glutamate (NAAG), attenuates sensitization to the psychomotor stimulant effects of cocaine. Rats received daily injections of cocaine (20.0 mg/kg/day; i.p.) or saline for 5 days. Fifteen minutes prior to these injections they received an i.p. injection of the NAALADase inhibitor, 2-PMPA (50.0-100 mg/kg), or vehicle. Locomotor activity and stereotypy produced by a challenge dose of cocaine (15.0 mg/kg) were assessed 3 days later. Acute cocaine administration increased locomotor activity in control animals. In animals with a prior history of cocaine administration, the behavioral response to cocaine was significantly enhanced. In animals that had received 2-PMPA in combination with cocaine, the enhancement of cocaine-induced locomotor activity was attenuated. No alteration in cocaine-evoked activity was observed in animals that had received once daily injections of 2-PMPA, alone. Acute administration of 2-PMPA also did not modify saline-induced locomotor activity or activity produced by an acute cocaine challenge. These data demonstrate that NAALADase inhibition attenuates the development of sensitization to the locomotor-activating effects of cocaine. Furthermore, this action cannot be attributed to an antagonism of the acute effects of cocaine. Copyright 2000 Wiley-Liss, Inc. JF - Synapse (New York, N.Y.) AU - Shippenberg, T S AU - Rea, W AU - Slusher, B S AD - Integrative Neuroscience Unit, Behavioral Neuroscience Laboratory, NIH/NIDA Intramural Research Program, Baltimore, Maryland 21224, USA. tshippen@intra.nida.nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 161 EP - 166 VL - 38 IS - 2 SN - 0887-4476, 0887-4476 KW - 2-(phosphonomethyl)pentanedioic acid KW - 0 KW - Dopamine Uptake Inhibitors KW - Organophosphorus Compounds KW - Carboxypeptidases KW - EC 3.4.- KW - Glutamate Carboxypeptidase II KW - EC 3.4.17.21 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Organophosphorus Compounds -- pharmacology KW - Male KW - Carboxypeptidases -- antagonists & inhibitors KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Cocaine -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72310096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Modulation+of+behavioral+sensitization+to+cocaine+by+NAALADase+inhibition.&rft.au=Shippenberg%2C+T+S%3BRea%2C+W%3BSlusher%2C+B+S&rft.aulast=Shippenberg&rft.aufirst=T&rft.date=2000-11-01&rft.volume=38&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-28 N1 - Date created - 2000-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors. AN - 72297821; 11008128 AB - Histones H2A and H2B are known to be reversibly post-translationally modified by ubiquitination. We previously observed in cultured tumor cells that proteasome inhibition stabilizes polyubiquitinated proteins, depletes unconjugated ubiquitin, and thereby promotes the deubiquitination of nucleosomal histones in chromatin. Provocative indirect evidence suggests that histone ubiquitination/deubiquitination cycles alter chromatin structure, which may limit accessibility of DNA repair proteins to damaged sites. In the present study, we focused on the relationship between the ubiquitination status of histone H2A, the structure of chromatin, and the efficiency of nucleotide excision repair (NER) of cisplatin-DNA adducts in human ovarian carcinoma cells exposed to the antitumor drug cisplatin. Pretreating cells with the proteasome inhibitor lactacystin (LC) or N-acetyl-leucyl-leucyl-norleucinal (ALLnL) induced deubiquitination of ubiquitinated histone H2A (uH2A) and concomitantly promoted chromatin condensation, increased the extent of cisplatin-DNA adducts, and diminished NER-dependent repair of cisplatin-DNA lesions, compared with control cells treated with cisplatin alone. Both proteasome inhibitors also prevented the increase in ERCC-1 mRNA expression that occurs in cells exposed to cisplatin. Cells treated with the combination of ALLnL and cisplatin underwent apoptosis, as indicated by caspase-dependent poly(ADP-ribose) polymerase (PARP) cleavage, more quickly than cells treated with either agent alone. Additionally, the combination of ALLnL and cisplatin potently increased p53 levels in cell lysates and stimulated the binding of p53 to chromatin. Together, these observations suggest that proteasome inhibition may be exploited therapeutically for its potential to sensitize ovarian tumor cells to cisplatin. JF - Biochemical pharmacology AU - Mimnaugh, E G AU - Yunmbam, M K AU - Li, Q AU - Bonvini, P AU - Hwang, S G AU - Trepel, J AU - Reed, E AU - Neckers, L AD - Tumor Cell Biology Section, Cell and Cancer Biology Department, Medicine Branch, National Cancer Institute, NIH, 20892, Bethesda, MD 20892, USA. edmim@boe-e.nih.gov Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 1343 EP - 1354 VL - 60 IS - 9 SN - 0006-2952, 0006-2952 KW - Antineoplastic Agents KW - 0 KW - Chromatin KW - DNA Adducts KW - DNA-Binding Proteins KW - Enzyme Inhibitors KW - Histones KW - Multienzyme Complexes KW - Proteins KW - RNA, Messenger KW - Ubiquitins KW - acetyl-leucinal-nor-leucinal KW - cisplatin-DNA adduct KW - lactacystin KW - 133343-34-7 KW - DNA KW - 9007-49-2 KW - PARP1 protein, human KW - EC 2.4.2.30 KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerases KW - ERCC1 protein, human KW - EC 3.1.- KW - Endonucleases KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Leucine KW - GMW67QNF9C KW - Cisplatin KW - Q20Q21Q62J KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Protein Biosynthesis KW - Cytosol -- metabolism KW - Drug Interactions KW - Chromatin -- metabolism KW - Cytosol -- drug effects KW - Humans KW - Proteins -- metabolism KW - Proteins -- genetics KW - RNA, Messenger -- biosynthesis KW - DNA -- drug effects KW - Ubiquitins -- metabolism KW - Cells, Cultured KW - Ovarian Neoplasms -- pathology KW - Histones -- metabolism KW - Chromatin -- drug effects KW - DNA -- chemistry KW - Female KW - Leucine -- analogs & derivatives KW - Apoptosis KW - Acetylcysteine -- analogs & derivatives KW - Multienzyme Complexes -- antagonists & inhibitors KW - Cisplatin -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Acetylcysteine -- pharmacology KW - Leucine -- pharmacology KW - Antineoplastic Agents -- pharmacology KW - DNA Repair -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72297821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Prevention+of+cisplatin-DNA+adduct+repair+and+potentiation+of+cisplatin-induced+apoptosis+in+ovarian+carcinoma+cells+by+proteasome+inhibitors.&rft.au=Mimnaugh%2C+E+G%3BYunmbam%2C+M+K%3BLi%2C+Q%3BBonvini%2C+P%3BHwang%2C+S+G%3BTrepel%2C+J%3BReed%2C+E%3BNeckers%2C+L&rft.aulast=Mimnaugh&rft.aufirst=E&rft.date=2000-11-01&rft.volume=60&rft.issue=9&rft.spage=1343&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=00062952&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brain atrophy and neuronal loss in alcoholism: a role for DNA damage? AN - 71219044; 10871692 AB - Chronic alcohol abuse has deleterious effects on several organs in the body including the brain. Neuroradiological studies have demonstrated that the brains of chronic alcoholics undergo loss of both gray and white matter volumes. Neuropathological studies using unbiased stereological methods have provided evidence for loss of neurons in specific parts of the brain in chronic alcoholics. The purpose of this paper is to propose a mechanism for this alcohol related neuronal loss. The hypothesis is based on the neurodegeneration observed in patients with the genetic disorder xeroderma pigmentosum (XP), who lack the capacity to carry out a specific type of DNA repair called nucleotide excision repair (NER). Some XP patients develop a progressive atrophic neurodegeneration, termed XP neurological disease, indicating that endogenous DNA damage that is normally repaired by NER has the capacity to cause neuronal death. Accumulating evidence indicates that the neurodegenerative DNA damage that is responsible for neuronal loss in XP patients results from reactive oxygen species (ROS) and lipid peroxidation products, and has the capacity to inhibit gene expression by RNA polymerase II. Therefore, the following model is proposed: chronic alcohol abuse results in increased levels of ROS and lipid peroxidation products in neurons, which results in an overwhelming burden on the NER pathway, and increased steady state levels of DNA lesions that inhibit gene expression. This results in neuronal death either by reduction in the levels of essential gene products or by apoptosis. The implications of this model for future studies are discussed. JF - Neurochemistry international AU - Brooks, P J AD - Section on Molecular Neurobiology, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, 12420 Parklawn Drive, MSC 8110, MD 20892-8110, Bethesda, USA. pjbrooks@dicbr.niaaa.nih.gov PY - 2000 SP - 403 EP - 412 VL - 37 IS - 5-6 SN - 0197-0186, 0197-0186 KW - Index Medicus KW - Xeroderma Pigmentosum -- pathology KW - DNA Repair KW - Humans KW - Nerve Degeneration -- pathology KW - Xeroderma Pigmentosum -- genetics KW - Atrophy KW - Alcoholism -- pathology KW - DNA Damage KW - Brain -- pathology KW - Alcoholism -- genetics KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71219044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Brain+atrophy+and+neuronal+loss+in+alcoholism%3A+a+role+for+DNA+damage%3F&rft.au=Brooks%2C+P+J&rft.aulast=Brooks&rft.aufirst=P&rft.date=2000-11-01&rft.volume=37&rft.issue=5-6&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-18 N1 - Date created - 2000-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transketolase gene expression in the cornea is influenced by environmental factors and developmentally controlled events. AN - 70783586; 11095059 AB - Transketolase (TKT) has been proposed to be a corneal crystallin, and its gene and protein are abundantly expressed in the corneal epithelium of several mammals. A marked up-regulation of TKT gene expression coincides with the time of eyelid opening in the mouse. Here, we examined whether exposure to incident light contributes to the up-regulation of TKT gene expression during cornea maturation. Mice were raised in either standard light/dark cycling conditions or total darkness. In some cases, subcutaneous injections of epidermal growth factor (EGF) were given beginning on the day of birth to induce early eyelid opening. RNA was prepared from the corneas of mothers and pups and subjected to Northern blot analyses. In addition, the relative levels of TKT mRNA and/or enzyme activity were examined in the corneas of human, bovine, rat, chicken, and zebrafish. TKT mRNA levels were 2.1-fold higher in the corneas of 25-day-old mouse pups ( 12 days after eyelid opening) that had been born and raised in light/dark conditions compared to pups born and raised in total darkness. By contrast, the level of TKT mRNA in the mature corneas of adult mice maintained in the dark for 2-8 weeks did not vary greatly from those of mice maintained in light/dark conditions. Interestingly, TKT mRNA levels in the corneas of dark-raised mice, although reduced, did exhibit the increase characteristically observed before and after eyelid opening. In addition, TKT mRNA levels were elevated fivefold in the corneas of 28-day-old mice raised in darkness and injected with EGF compared to uninjected mice also deprived of light. The EGF-injected mice opened their eyes 3 days early, and their corneal epithelium did not grossly differ from that of control mice. TKT mRNA and/or enzyme activity was found to be much higher in the corneas than in other tissues of humans, bovines, and rats but was extremely low in the corneas of chicken and zebrafish. Our studies suggest that both exposure to incident light and events surrounding the process of eyelid opening play a role in the up-regulation of TKT gene expression observed during corneal maturation in mice. Light appears to play a less important role in the mature cornea in maintaining high levels of TKT gene expression. The low levels of TKT in the cornea of chicken and zebrafish support the notion that TKT acts as a taxon-specific enzyme-crystallin in mammals. The involvement of environmental signals for this putative, mammalian cornea crystallin contrasts with the purely developmental signals involved in the up-regulation of the crystallin genes of the lens. JF - Cornea AU - Sax, C M AU - Kays, W T AU - Salamon, C AU - Chervenak, M M AU - Xu, Y S AU - Piatigorsky, J AD - Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892-2730, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 833 EP - 841 VL - 19 IS - 6 SN - 0277-3740, 0277-3740 KW - RNA, Messenger KW - 0 KW - Epidermal Growth Factor KW - 62229-50-9 KW - Transketolase KW - EC 2.2.1.1 KW - Index Medicus KW - Darkness KW - Aging -- metabolism KW - Animals KW - Blotting, Northern KW - Humans KW - Rabbits KW - Mice KW - Epidermal Growth Factor -- pharmacology KW - Zebrafish KW - Pregnancy KW - Rats KW - Animals, Newborn KW - Cattle KW - Chickens KW - Adult KW - Light KW - Male KW - Cell Line KW - Female KW - RNA, Messenger -- metabolism KW - Epithelium, Corneal -- drug effects KW - Gene Expression KW - Epithelium, Corneal -- enzymology KW - Environmental Exposure KW - Epithelium, Corneal -- cytology KW - RNA, Messenger -- genetics KW - Transketolase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70783586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cornea&rft.atitle=Transketolase+gene+expression+in+the+cornea+is+influenced+by+environmental+factors+and+developmentally+controlled+events.&rft.au=Sax%2C+C+M%3BKays%2C+W+T%3BSalamon%2C+C%3BChervenak%2C+M+M%3BXu%2C+Y+S%3BPiatigorsky%2C+J&rft.aulast=Sax&rft.aufirst=C&rft.date=2000-11-01&rft.volume=19&rft.issue=6&rft.spage=833&rft.isbn=&rft.btitle=&rft.title=Cornea&rft.issn=02773740&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-03-01 N1 - Date created - 2001-02-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reduction of 1,3-diphenyl-1-triazene by rat hepatic microsomes, by cecal microflora, and in rats generates the phenyl radical metabolite: nn ESR spin-trapping investigation. AN - 70775873; 11087429 AB - An ESR spin-trapping technique was used to determine whether free radical metabolites are formed as a result of the reduction of 1, 3-diphenyl-1-triazene (DPT) in vivo and in vitro by components of the cytochrome P450 (P450) mixed-function oxidase system in microsomes or by gut microflora in anaerobic cecal incubations. The ESR spectrum of the DMPO-phenyl radical adduct was detected in a microsomal incubation containing DPT, DMPO, and NADPH with the following hyperfine coupling constants: a(N) = 15.95 G and = 24.37 G. The amplitude of the spectrum from the phenyl radical adduct generated in microsomal incubations of DPT with DMPO and NADPH was not attenuated by the P450 inhibitor 1-aminobenzotriazole (ABT) or by carbon monoxide, indicating that P450 is not significantly involved in phenyl radical formation. The formation of a DMPO-phenyl radical adduct was also catalyzed by recombinant human cytochrome P450 reductase. Addition of anti-rat P450 reductase antibody led to an attenuation of the signal in incubations containing either microsomes or reductase. Low concentrations of DMPO-phenyl radical adducts were detected by ESR in the toluene extract of cecal contents containing DPT and the spin trap. In the in vivo experiments with rats treated with DPT and the spin trap DMPO, the six-line ESR signal of the DMPO-phenyl radical adduct was readily detected in bile 40-60 min after rats were treated with DPT and DMPO. The results show for the first time that the phenyl radical is formed by the reduction of DPT and may indicate a toxic potential for this chemical. JF - Chemical research in toxicology AU - Kadiiska, M B AU - De Costa, K S AU - Mason, R P AU - Mathews, J M AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Kadiiska@niehs.nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1082 EP - 1086 VL - 13 IS - 11 SN - 0893-228X, 0893-228X KW - Benzene Derivatives KW - 0 KW - Cyclic N-Oxides KW - Food Additives KW - Free Radicals KW - Recombinant Proteins KW - Spin Labels KW - Triazenes KW - 1,3-diphenyl-1-triazene KW - 5T4EEW75HJ KW - 5,5-dimethyl-1-pyrroline-1-oxide KW - 7170JZ1QF3 KW - Mixed Function Oxygenases KW - EC 1.- KW - NADPH-Ferrihemoprotein Reductase KW - EC 1.6.2.4 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Electron Spin Resonance Spectroscopy -- methods KW - Animals KW - Rats, Inbred F344 KW - Mixed Function Oxygenases -- metabolism KW - Recombinant Proteins -- metabolism KW - Humans KW - Cyclic N-Oxides -- metabolism KW - NADPH-Ferrihemoprotein Reductase -- metabolism KW - Free Radicals -- chemistry KW - Cyclic N-Oxides -- chemistry KW - Free Radicals -- metabolism KW - Male KW - Triazenes -- metabolism KW - Benzene Derivatives -- chemistry KW - Microsomes, Liver -- enzymology KW - Benzene Derivatives -- metabolism KW - Food Additives -- metabolism KW - Cecum -- microbiology KW - Cecum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70775873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Reduction+of+1%2C3-diphenyl-1-triazene+by+rat+hepatic+microsomes%2C+by+cecal+microflora%2C+and+in+rats+generates+the+phenyl+radical+metabolite%3A+nn+ESR+spin-trapping+investigation.&rft.au=Kadiiska%2C+M+B%3BDe+Costa%2C+K+S%3BMason%2C+R+P%3BMathews%2C+J+M&rft.aulast=Kadiiska&rft.aufirst=M&rft.date=2000-11-01&rft.volume=13&rft.issue=11&rft.spage=1082&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethylene glycol generates free radical metabolites in rats: an ESR in vivo spin trapping investigation. AN - 70768689; 11087442 AB - Ethylene glycol, best known as antifreeze, is most often ingested accidentally or as a substitute for alcochol by chronic alcohol abusers. The toxicity of ethylene glycol poisoning is due to its toxic metabolites rather than to ethylene glycol itself. In this study, electron spin resonance (ESR) spectroscopy has been used to study free radical generation in rats by acute ethylene glycol poisoning. The radical spin trapping technique was applied where the spin trapping agent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) reacted with free radical metabolites to form radical adducts in vivo. The radical adducts from ethylene glycol intoxication were detected in both the bile and urine samples of male Sprague-Dawley rats. The identification of the POBN-(.)[(13)C]ethylene glycol radical adduct provides for the first time direct ESR evidence for the generation of the ethylene glycol-derived radicals during acute intoxication by ethylene glycol, suggesting a new metabolic pathway. Simultaneous administration of alcohol dehydrogenase inhibitor 4-methylpyrazole with ethylene glycol resulted in an enhanced free radical generation in the bile. This report is the first evidence of ethylene glycol free radical metabolism in rats with acute ethylene glycol intoxication. JF - Chemical research in toxicology AU - Kadiiska, M B AU - Mason, R P AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Kadiiska@niehs.nih.gov Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 1187 EP - 1191 VL - 13 IS - 11 SN - 0893-228X, 0893-228X KW - Chelating Agents KW - 0 KW - Free Radicals KW - Nitrogen Oxides KW - Pyridines KW - Spin Labels KW - alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone KW - Ethylene Glycol KW - FC72KVT52F KW - Deferoxamine KW - J06Y7MXW4D KW - Index Medicus KW - Bile -- chemistry KW - Free Radicals -- analysis KW - Free Radicals -- toxicity KW - Animals KW - Free Radicals -- urine KW - Bile -- metabolism KW - Free Radicals -- metabolism KW - Rats KW - Chelating Agents -- pharmacology KW - Rats, Sprague-Dawley KW - Spin Trapping KW - Deferoxamine -- pharmacology KW - Electron Spin Resonance Spectroscopy KW - Lipid Metabolism KW - Male KW - Ethylene Glycol -- urine KW - Ethylene Glycol -- toxicity KW - Ethylene Glycol -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70768689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Ethylene+glycol+generates+free+radical+metabolites+in+rats%3A+an+ESR+in+vivo+spin+trapping+investigation.&rft.au=Kadiiska%2C+M+B%3BMason%2C+R+P&rft.aulast=Kadiiska&rft.aufirst=M&rft.date=2000-11-01&rft.volume=13&rft.issue=11&rft.spage=1187&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-18 N1 - Date created - 2000-12-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor. AN - 70539525; 12214090 AB - The amyloid beta protein precursor (AbetaPP) is sequentially processed by beta- and gamma-secretases to generate the Abeta peptide. The biochemical path leading to Abeta formation has been extensively studied since extracellular aggregates of amyloidogenic forms of Abeta peptide (Abeta42) are considered the culprit of Alzheimer's disease. Aside from its pathological relevance, the biological role of AbetaPP proteolysis is unknown. Although never previously described, cleavage of AbetaPP by gamma-secretase should release, together with Abeta, a COOH-terminal AbetaPP Intracellular Domain, herein termed AID. We have now identified AID-like peptides in brain tissue of normal control and patients with sporadic Alzheimer's disease and demonstrate that AID acts as a positive regulator of apoptosis. Thus, overproduction of AID may add to the toxic effect of Abeta42 aggregates and further accelerate neurodegeneration. JF - Journal of Alzheimer's disease : JAD AU - Passer, B AU - Pellegrini, L AU - Russo, C AU - Siegel, R M AU - Lenardo, M J AU - Schettini, G AU - Bachmann, M AU - Tabaton, M AU - D'Adamio, L AD - T-cell apoptosis Unit, Laboratory of Cellular and Molecular Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 289 EP - 301 VL - 2 IS - 3-4 SN - 1387-2877, 1387-2877 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70539525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.atitle=Generation+of+an+apoptotic+intracellular+peptide+by+gamma-secretase+cleavage+of+Alzheimer%27s+amyloid+beta+protein+precursor.&rft.au=Passer%2C+B%3BPellegrini%2C+L%3BRusso%2C+C%3BSiegel%2C+R+M%3BLenardo%2C+M+J%3BSchettini%2C+G%3BBachmann%2C+M%3BTabaton%2C+M%3BD%27Adamio%2C+L&rft.aulast=Passer&rft.aufirst=B&rft.date=2000-11-01&rft.volume=2&rft.issue=3-4&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.issn=13872877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-05 N1 - Date created - 2004-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The mouse Spo11 gene is required for meiotic chromosome synapsis. AN - 70512131; 11106738 AB - The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks (DSBs) and is required for meiotic synapsis in S. cerevisiae. Surprisingly, Spo11 homologs are dispensable for synapsis in C. elegans and Drosophila yet required for meiotic recombination. Disruption of mouse Spo11 results in infertility. Spermatocytes arrest prior to pachytene with little or no synapsis and undergo apoptosis. We did not detect Rad51/Dmc1 foci in meiotic chromosome spreads, indicating DSBs are not formed. Cisplatin-induced DSBs restored Rad51/Dmc1 foci and promoted synapsis. Spo11 localizes to discrete foci during leptotene and to homologously synapsed chromosomes. Other mouse mutants that arrest during meiotic prophase (Atm -/-, Dmc1 -/-, mei1, and Morc(-/-)) showed altered Spo11 protein localization and expression. We speculate that there is an additional role for Spo11, after it generates DSBs, in synapsis. JF - Molecular cell AU - Romanienko, P J AU - Camerini-Otero, R D AD - Genetics and Biochemistry Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health 20892, Bethesda, MD, USA. Y1 - 2000/11// PY - 2000 DA - November 2000 SP - 975 EP - 987 VL - 6 IS - 5 SN - 1097-2765, 1097-2765 KW - Cell Cycle Proteins KW - 0 KW - DNA-Binding Proteins KW - Proteins KW - RNA, Messenger KW - Saccharomyces cerevisiae Proteins KW - RAD51 protein, S cerevisiae KW - EC 2.7.7.- KW - Rad51 Recombinase KW - Rad51 protein, mouse KW - Endodeoxyribonucleases KW - EC 3.1.- KW - Esterases KW - meiotic recombination protein SPO11 KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Animals KW - Sequence Homology, Nucleic Acid KW - Chromosomes -- drug effects KW - RNA, Messenger -- genetics KW - Spermatocytes -- pathology KW - Mice, Knockout KW - Mutagenesis, Site-Directed KW - Ovary -- metabolism KW - Ovary -- pathology KW - Apoptosis -- drug effects KW - Cisplatin -- pharmacology KW - Chromosomes -- metabolism KW - Infertility, Female -- genetics KW - Fluorescent Antibody Technique KW - Male KW - Ovary -- embryology KW - DNA-Binding Proteins -- metabolism KW - Infertility, Female -- pathology KW - Testis -- metabolism KW - Alternative Splicing -- genetics KW - Testis -- pathology KW - RNA, Messenger -- analysis KW - Adenosine Triphosphatases -- metabolism KW - Spermatocytes -- drug effects KW - Mice KW - DNA Damage -- drug effects KW - Gene Deletion KW - Spermatocytes -- metabolism KW - Infertility, Male -- pathology KW - Infertility, Male -- genetics KW - Female KW - Protein Transport KW - Esterases -- genetics KW - Meiosis -- drug effects KW - Esterases -- metabolism KW - Esterases -- deficiency KW - Meiosis -- genetics KW - Chromosome Pairing -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70512131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=The+mouse+Spo11+gene+is+required+for+meiotic+chromosome+synapsis.&rft.au=Romanienko%2C+P+J%3BCamerini-Otero%2C+R+D&rft.aulast=Romanienko&rft.aufirst=P&rft.date=2000-11-01&rft.volume=6&rft.issue=5&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=10972765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-22 N1 - Date created - 2002-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Energy and fat intakes of children and adolescents in the United States: data from the National Health and Nutrition Examination Surveys AN - 18289185; 5342141 AB - Dietary factors related to body weight and chronic disease risk are of interest because of recent increases in the prevalence of overweight. Secular trends in energy and fat intakes of youths aged 2-19 y were assessed. Current intakes were compared with recommendations. Dietary 24-h recall data from the third National Health and Nutrition Examination Survey (1988-1994) and earlier national surveys were examined. Mean energy intake changed little from the 1970s to 1988-1994 except for an increase among adolescent females. Over the same time period, the mean percentage of energy from total and saturated fat decreased, but remained above recommendations, with overall means of 33.5% of energy from fat and 12.2% of energy from saturated fat. In 1988-1994, approximately 1 in 4 youths met the recommendations for intakes of fat and saturated fat and 3 in 4 met the recommendation for cholesterol intake. Beverages contributed 20-24% of energy across all ages and soft drinks provided 8% of energy in adolescents. Except for adolescent girls, beverage energy contributions were generally higher among overweight than nonoverweight youths; soft drink energy contribution was higher among overweight youths than among nonoverweight youths for all groups. The lack of evidence of a general increase in energy intake among youths despite an increase in the prevalence of overweight suggests that physical inactivity is a major public health challenge in this age group. Efforts to increase physical activity and decrease nonnutritive sources of energy may be important approaches to counter the rise in overweight prevalence. JF - American Journal of Clinical Nutrition AU - Troiano, R P AU - Briefel, R R AU - Carroll, MD AU - Bialostosky, K AD - Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1343S EP - 1353S VL - 72 IS - 5 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - USA KW - Health (status) KW - Adolescence KW - Energy KW - Health (behavior) KW - Diet KW - Children KW - Nutrition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18289185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Energy+and+fat+intakes+of+children+and+adolescents+in+the+United+States%3A+data+from+the+National+Health+and+Nutrition+Examination+Surveys&rft.au=Troiano%2C+R+P%3BBriefel%2C+R+R%3BCarroll%2C+MD%3BBialostosky%2C+K&rft.aulast=Troiano&rft.aufirst=R&rft.date=2000-11-01&rft.volume=72&rft.issue=5&rft.spage=1343S&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Energy; Diet; Health (behavior); Health (status); Children; Adolescence; Nutrition; USA ER - TY - JOUR T1 - Human Immune Response to Streptococcal Inhibitor of Complement, a Serotype M1 Group A Streptococcus Extracellular Protein Involved in Epidemics AN - 18101358; 5200697 AB - Streptococcal inhibitor of complement (Sic) is a highly polymorphic extracellular protein made by serotype M1 group A Streptococcus strains that contributes to bacterial persistence in the mammalian upper respiratory tract. New variants of the Sic protein arise very rapidly by positive selection in human populations during M1 epidemics. The human antibody response to Sic was analyzed. Of 636 persons living in diverse localities, 43% had anti-Sic serum antibodies, but only 16.4% had anti_M1 protein serum antibody. Anti-Sic antibody was also present in nasal wash specimens in high frequency. Linear B cell epitope mapping showed that serum antibodies recognized epitopes located in structurally variable regions of Sic and the amino terminal hypervariable region of the M1 protein. Phage display analyses confirmed that the polymorphic regions of Sic are primary targets of host antibodies. These results support the hypothesis that selection of Sic variants occurs on mucosal surfaces by a mechanism that involves acquired host antibody. JF - Journal of Infectious Diseases AU - Hoe, N P AU - Kordari, P AU - Cole, R AU - Liu, M AU - Palzkill, T AU - Huang, W AU - McLellan, D AU - Adams, G J AU - Hu, M AU - Vuopio-Varkila, J AU - Cate, T R AU - Pichichero, ME AU - Edwards, K M AU - Eskola, J AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1425 EP - 1436 VL - 182 IS - 5 SN - 0022-1899, 0022-1899 KW - streptococci KW - Sic protein KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Epidemics KW - Complement KW - Immune response KW - Persistent infection KW - Respiratory tract KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18101358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Human+Immune+Response+to+Streptococcal+Inhibitor+of+Complement%2C+a+Serotype+M1+Group+A+Streptococcus+Extracellular+Protein+Involved+in+Epidemics&rft.au=Hoe%2C+N+P%3BKordari%2C+P%3BCole%2C+R%3BLiu%2C+M%3BPalzkill%2C+T%3BHuang%2C+W%3BMcLellan%2C+D%3BAdams%2C+G+J%3BHu%2C+M%3BVuopio-Varkila%2C+J%3BCate%2C+T+R%3BPichichero%2C+ME%3BEdwards%2C+K+M%3BEskola%2C+J&rft.aulast=Hoe&rft.aufirst=N&rft.date=2000-11-01&rft.volume=182&rft.issue=5&rft.spage=1425&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus; Immune response; Complement; Epidemics; Persistent infection; Respiratory tract ER - TY - JOUR T1 - HIV-Inhibitory Prenylated Xanthones and Flavones from Maclura tinctoria AN - 17844085; 4879719 AB - The organic extract of the plant Maclura tinctoria exhibited moderate anti-HIV activity. Seven prenylated phenolic derivatives were isolated from the active fractions and characterized by spectroanalytical methods. New compounds macluraxanthone B (1), macluraxanthone C (2), and dihydrocudraflavone B (8) were identified. JF - Journal of Natural Products AU - Groweiss, A AU - Cardellina, J H AU - Boyd, M R AD - Laboratory of Drug Discovery Research and Development, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, Maryland 21702-1201, USA, boyd@dtpax2.ncifcrf.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1537 EP - 1539 VL - 63 IS - 11 SN - 0163-3864, 0163-3864 KW - HIV KW - Flavones KW - Xanthones KW - dihydrocudraflavone B KW - macluraxanthone KW - prenylated phenols KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Antiviral agents KW - Human immunodeficiency virus KW - Plant extracts KW - V 22002:AIDS: Molecular and in vitro aspects KW - A 01068:Antiviral & viricidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17844085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=HIV-Inhibitory+Prenylated+Xanthones+and+Flavones+from+Maclura+tinctoria&rft.au=Groweiss%2C+A%3BCardellina%2C+J+H%3BBoyd%2C+M+R&rft.aulast=Groweiss&rft.aufirst=A&rft.date=2000-11-01&rft.volume=63&rft.issue=11&rft.spage=1537&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Antiviral agents; Plant extracts; Acquired immune deficiency syndrome ER - TY - JOUR T1 - Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis AN - 17838897; 4866050 AB - Genetic and biochemical evidence has implicated two different target enzymes for isoniazid (INH) within the unique type II fatty acid synthase (FAS) system involved in the production of mycolic acids. These two components are an enoyl acyl carrier protein (ACP) reductase, InhA, and a beta -ketoacyl-ACP synthase, KasA. We compared the consequences of INH treatment of Mycobacterium tuberculosis (MTB) with two inhibitors having well-defined targets: triclosan (TRC), which inhibits InhA; and thiolactomycin (TLM), which inhibits KasA. INH and TLM, but not TRC, upregulate the expression of an operon containing five FAS II components, including kasA and acpM. Although all three compounds inhibit mycolic acid synthesis, treatment with INH and TLM, but not with TRC, results in the accumulation of ACP-bound lipid precursors to mycolic acids that were 26 carbons long and fully saturated. TLM-resistant mutants of MTB were more cross-resistant to INH than TRC-resistant mutants. Overexpression of KasA conferred more resistance to TLM and INH than to TRC. Overexpression of InhA conferred more resistance to TRC than to INH and TLM. Co-overexpression of both InhA and KasA resulted in strongly enhanced levels of INH resistance, in addition to cross-resistance to both TLM and TRC. These results suggest that these components of the FAS II complex are not independently regulated and that alterations in the expression level of InhA affect expression levels of KasA. Nonetheless, INH appeared to resemble TLM more closely in overall mode of action, and KasA levels appeared to be tightly correlated with INH sensitivity. JF - Molecular Microbiology AU - Slayden, A R AU - Lee, E R AU - Barry, E C AD - Tuberculosis Research Section, Twinbrook II, Room 239, Laboratory of Host Defenses,12441 Parklawn Drive, NIAID, Rockville, MD 20852, USA. Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 514 EP - 525 PB - Blackwell Science Ltd VL - 38 IS - 3 SN - 0950-382X, 0950-382X KW - KasA protein KW - enoyl-(acyl carrier protein) reductase (NADH) KW - thiolactomycin KW - triclosan KW - Microbiology Abstracts B: Bacteriology KW - Isoniazid KW - Fatty-acid synthase KW - Mycobacterium tuberculosis KW - J 02793:Antibiotics: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17838897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Isoniazid+affects+multiple+components+of+the+type+II+fatty+acid+synthase+system+of+Mycobacterium+tuberculosis&rft.au=Slayden%2C+A+R%3BLee%2C+E+R%3BBarry%2C+E+C&rft.aulast=Slayden&rft.aufirst=A&rft.date=2000-11-01&rft.volume=38&rft.issue=3&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium tuberculosis; Fatty-acid synthase; Isoniazid ER - TY - JOUR T1 - Treatment of infections in the patient with Mendelian susceptibility to mycobacterial infection AN - 17832866; 4864061 AB - Cytokines are increasingly used for the therapy of infections in patient populations with special defects in immunity (chemotherapy, bone marrow transplantation, chronic granulomatous disease). The recognition of multiple defects in the systems of the interferon- gamma (IFN- gamma ) receptor, interleukin-12 (IL-12) receptor and IL-12 p40 emphasizes the critical roles that cytokines play in preventing and clearing infection. The cases of patients with partially responsive IFN- gamma receptors (autosomal dominant and partial defects) are ideal candidates for successful cytokine prophylaxis and therapy. Better understanding of the critical elements of the cytokine pathways may show us ways to circumvent these defects with complementary cytokine cascades. JF - Microbes and Infection AU - Holland, S M AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, 11N103, 10 Center Dr., MSC 1886, Bethesda, MD 20892-1886, USA, smh@nih.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1579 EP - 1590 VL - 2 IS - 13 SN - 1286-4579, 1286-4579 KW - Microbiology Abstracts B: Bacteriology KW - Interleukin 12 KW - ^g-Interferon KW - Mycobacterium KW - Receptors KW - Immunodeficiency KW - Cytokines KW - Antibacterial agents KW - J 02833:Immune response and immune mechanisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17832866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Treatment+of+infections+in+the+patient+with+Mendelian+susceptibility+to+mycobacterial+infection&rft.au=Holland%2C+S+M&rft.aulast=Holland&rft.aufirst=S&rft.date=2000-11-01&rft.volume=2&rft.issue=13&rft.spage=1579&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mycobacterium; Immunodeficiency; ^g-Interferon; Interleukin 12; Receptors; Antibacterial agents; Cytokines ER - TY - JOUR T1 - Development of microsatellite markers in the guanaco, Lama guanicoe: utility for South American camelids AN - 17830277; 4866243 JF - Molecular Ecology AU - Sarno, J R AU - David, A V AU - Franklin, L W AU - O'Brien, J S AU - Johnson, E W AD - Laboratory of Genomic Diversity, NCI-C, Frederick, MD, 21702-1201, USA,Department of Animal Ecology, Iowa State University, Ames, IA 50011, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 1922 EP - 1924 PB - Blackwell Science Ltd VL - 9 IS - 11 SN - 0962-1083, 0962-1083 KW - South America KW - guanaco KW - Ecology Abstracts; Genetics Abstracts KW - Genetic markers KW - Microsatellites KW - Ecological genetics KW - Lama guanicoe KW - Markers KW - G 07409:Ruminantia (nondomestic and camelids) KW - D 04672:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17830277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Ecology&rft.atitle=Development+of+microsatellite+markers+in+the+guanaco%2C+Lama+guanicoe%3A+utility+for+South+American+camelids&rft.au=Sarno%2C+J+R%3BDavid%2C+A+V%3BFranklin%2C+L+W%3BO%27Brien%2C+J+S%3BJohnson%2C+E+W&rft.aulast=Sarno&rft.aufirst=J&rft.date=2000-11-01&rft.volume=9&rft.issue=11&rft.spage=1922&rft.isbn=&rft.btitle=&rft.title=Molecular+Ecology&rft.issn=09621083&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lama guanicoe; Genetic markers; Microsatellites; Ecological genetics; Markers ER - TY - JOUR T1 - Upper Respiratory Tract Toxicity of Inhaled Methylvinyl Ketone in F344 Rats and B6C3F1 Mice AN - 17807898; 4848643 AB - The National Toxicology Program is conducting a chemical class study to investigate the structure-activity relationships for the toxicity of alpha , beta -unsaturated ketones. Methylvinyl ketone (MVK) was selected for study because it is a representative straight-chain aliphatic alpha , beta -unsaturated ketone and because of its extensive use and widespread exposure. Short-term inhalation studies of MVK were conducted to provide toxicity data for comparison with other alpha , beta -unsaturated ketones and for use in designing chronic toxicity and carcinogenicity studies. In 2-week studies, rats and mice were exposed to 0, 0.25, 0.5, 1, 2, 4, or 8 ppm MVK 6 h/day, 5 days/week for 12 exposures. Morbidity and early deaths occurred in all male and female rats after 1 exposure and in 2 male mice after 10 exposures to 8 ppm. Rats exhibited nasal cavity toxicity and lung necrosis at 4 ppm. No toxicity was observed in animals exposed to less than 2 ppm. Based on these results a 13-week study was conducted at 0, 0.5, 1, and 2 ppm MVK. As observed in the 2-week study, the nasal cavity was the main target organ and rats were more sensitive than mice. Respiratory and olfactory epithelial necrosis were prominent by day 21 in the rat. At study termination these lesions were still evident but not as severe as noted earlier. Additionally, changes such as olfactory epithelial regeneration and metaplasia (respiratory) as well as respiratory epithelial hyperplasia and metaplasia (squamous) were clearly evident. Nasal lesions in mice were limited to a subtle squamous metaplasia of transitional and/or respiratory epithelium covering predominantly the tips of naso- and maxilloturbinates in Levels I and II. A transient, leukopenia was observed in rats exposed to 2 ppm, however, this effect was not present after 13 weeks of exposure. In mice, leukocyte counts were significantly decreased at all exposure concentrations after 13 weeks of exposure. Absolute testicular and epididymal weights and sperm counts were decreased at the high dose only. MVK can be characterized as a reactive, direct-acting gaseous irritant. MVK exposure causes the same nasal cavity lesions as the cyclic alpha , beta -unsaturated ketone, 2-cyclohexen-1-one, although at lower exposure concentrations. JF - Toxicological Sciences AU - Morgan, D L AU - Price, H C AU - O'Connor, R W AU - Seely, J C AU - Ward, S M AU - Wilson, R E AU - Cunningham, M C AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 182 EP - 194 VL - 58 IS - 1 SN - 1096-6080, 1096-6080 KW - rats KW - mice KW - methyl vinyl ketone KW - Toxicology Abstracts KW - Inhalation KW - Necrosis KW - Olfactory epithelium KW - Respiratory tract KW - X 24152:Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17807898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Upper+Respiratory+Tract+Toxicity+of+Inhaled+Methylvinyl+Ketone+in+F344+Rats+and+B6C3F1+Mice&rft.au=Morgan%2C+D+L%3BPrice%2C+H+C%3BO%27Connor%2C+R+W%3BSeely%2C+J+C%3BWard%2C+S+M%3BWilson%2C+R+E%3BCunningham%2C+M+C&rft.aulast=Morgan&rft.aufirst=D&rft.date=2000-11-01&rft.volume=58&rft.issue=1&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Inhalation; Respiratory tract; Olfactory epithelium; Necrosis ER - TY - JOUR T1 - Can alcohol promote aromatization of androgens to estrogens? A review AN - 17799472; 4845557 AB - Increased aromatization may be a mechanism for feminization of some male alcoholics, as well as for the reported increases in plasma estrogen levels in postmenopausal women subjected to moderate alcohol consumption. Alcohol consumption-related increases in estrogen levels may in turn be partially responsible for the associated decreased risk for coronary artery disease and osteoporosis, as well as for increased risk for breast cancer. The purpose of this review is to evaluate the literature to determine whether alcohol can promote aromatization of androgens to estrogens. In male rats, chronic heavy alcohol administration (36% of total calories = 12-18 g/kg/day) led to increased aromatization of androgen in the liver, but the results were equivocal for the hypothalamus. In female rats, chronic heavy alcohol administration did not promote aromatization in the hypothalamus exposed to alcohol in utero. In human placental tissue, although ex vivo alcohol administration (less or more than 72 g/day) did not affect the rate of aromatization, in vitro incubation of choriocarcinoma cells with 5-50 mM of alcohol increased estradiol secretion, which could be due to increased aromatization. In in vitro human ovarian granulosa cell studies, alcohol increased, had no effect on, or decreased estradiol secretion, and in one study, 20 mM of alcohol significantly increased aromatization of androstenedione to estrogens. These results may not be fully relevant to normal human ovary because in both studies cells were heavily luteinized by gonadotropins. A study of ovariectomized rats shows that only heavy chronic alcohol intake (4.4 g/kg/day) for 10 weeks can increase plasma estradiol levels and uterine weight, which could be due to increased aromatization or delayed clearance of estradiol. In conclusion, chronic heavy alcohol administration can result in aromatization of androgens in male rat liver. It is not clear whether moderate alcohol intake can produce a similar effect in the liver, nor whether alcohol can potentiate aromatization of androgens in other tissue or organs of male rats. In females, the available information is not adequate to evaluate the effect of alcohol on aromatization. Further studies are required in both genders to evaluate the ability of alcohol (moderate vs. heavy dose) to promote aromatization of androgens to estrogens. JF - Alcohol AU - Purohit, V AD - Division of Basic Research, Biomedical Research Branch, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Suite 402, 6000 Executive Boulevard, Bethesda, MD 20892-7003, USA, vpurohit@willco.niaaa.nih.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 123 EP - 127 VL - 22 IS - 3 SN - 0741-8329, 0741-8329 KW - rats KW - aromatization KW - Toxicology Abstracts KW - Estrogens KW - Reviews KW - Ovariectomy KW - Androgens KW - Ethanol KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17799472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Can+alcohol+promote+aromatization+of+androgens+to+estrogens%3F+A+review&rft.au=Purohit%2C+V&rft.aulast=Purohit&rft.aufirst=V&rft.date=2000-11-01&rft.volume=22&rft.issue=3&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ethanol; Androgens; Estrogens; Ovariectomy; Reviews ER - TY - JOUR T1 - Membrane Transporters and Antifungal Drug Resistance AN - 17778298; 4825453 AB - Over the last 30 years or so, the incidence of invasive fungal infections in man has risen dramatically. Patients that become severely immunocompromised because of underlying diseases such as leukemia or recently, acquired immunodeficiency syndrome or patients who undergo cancer chemotherapy or organ transplantation, are particularly susceptible to opportunistic fungal infections. Although Candida species continue to be the major pathogenic fungi in these patients, cryptococcosis, aspergillosis, and coccidioidomycosis, among others, have become increasingly important mycoses. Antifungal drugs currently being used in clinic include polyene antibiotics, azole derivatives and 5-fluorocytosine. With the exception of the latter, all other drugs possess mechanisms of action aimed at disrupting the integrity of the fungal cell membrane by either interfering with the biosynthesis of membrane sterols or by inhibiting sterol functions. However, one significant obstacle preventing successful antifungal therapy is the dramatic increase in drug resistance, especially against azole antimycotics. Among the major mechanisms by which fungi invoke drug resistance is the overexpression of extrusion pumps able to facilitate the efflux of cytotoxic drugs from the cell thus leading to decreased drug accumulation and diminished concentrations. Since the initial observations that azole resistance by fungi may be caused by overexpression of multidrug efflux transporter genes, significant advances have been achieved primarily with Saccharomyces cerevisiae and Candida albicans. The purpose of this review is to discuss various aspects of multidrug resistance in fungi such as antifungal drug mechanisms of action and fungal molecular genetics in the context of targeted drug discovery. The role that membrane transporter proteins play in drug resistance in various species of Candida, Aspergillus and Cryptococcus will be address in more detail, as will be their importance as selective drug targets in the design of novel antifungal agents. JF - Current Drug Targets AU - St.Georgiev, V AD - 7600-B Rockledge Drive, Room 2102, Bethesda, Maryland 20892, USA, vg8q@nih.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 261 EP - 284 VL - 1 IS - 3 SN - 1389-4501, 1389-4501 KW - man KW - Aspergillus KW - Candida KW - Saccharomyces cerevisiae KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Antifungal agents KW - Drug resistance KW - Coccidioidomycosis KW - Aspergillosis KW - Cryptococcosis KW - W3 33370:Antibiotics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17778298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Drug+Targets&rft.atitle=Membrane+Transporters+and+Antifungal+Drug+Resistance&rft.au=St.Georgiev%2C+V&rft.aulast=St.Georgiev&rft.aufirst=V&rft.date=2000-11-01&rft.volume=1&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Current+Drug+Targets&rft.issn=13894501&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Antifungal agents; Drug resistance; Cryptococcosis; Aspergillosis; Coccidioidomycosis ER - TY - JOUR T1 - Structural Preordering in the N-Terminal Region of Ribosomal Protein S4 Revealed by Heteronuclear NMR Spectroscopy AN - 17746811; 4811449 AB - Protein S4, a component of the 30S subunit of the prokaryotic ribosome, is one of the first proteins to interact with rRNA in the process of ribosome assembly and is known to be involved in the regulation of this process. While the structure of the C-terminal 158 residues of Bacillus stearothermophilus S4 has been solved by both X-ray crystallography and NMR, that of the N-terminal 41 residues is unknown. Evidence suggests that the N-terminus is necessary both for the assembly of functional ribosomes and for full binding to 16S RNA, and so we present NMR data collected on the full-length protein (200 aa). Our data indicate that the addition of the N-terminal residues does not significantly change the structure of the C-terminal 158 residues. The data further indicate that the N-terminus is highly flexible in solution, without discernible secondary structure. Nevertheless, structure calculations based on nuclear Overhauser effect spectroscopic data combined with super(15)N relaxation data revealed that two short segments in the N-terminus, S sub(12)RRL sub(15) and P sub(30)YPP sub(33), adopt transiently ordered states in solution. The major conformation of S sub(12)-RRL sub(15) appears to orient the arginine side chains outward toward the solvent in a parallel fashion, while that of P sub(30)YPP sub(33) forms a nascent turn of a polyproline II helix. These segments contain residues that are highly conserved across many prokaryotic species, and thus they are reasonable candidates respectively for sites of interaction with RNA and other ribosomal proteins within the intact ribosome. JF - Biochemistry (Washington) AU - Sayers, E W AU - Gerstner, R B AU - Draper, DE AU - Torchia, DA AD - Molecular Structural Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4307, Bethesda, MD 20892-4307, USA, dtorchia@dir.nidcr.nih.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 13602 EP - 13613 VL - 39 IS - 44 SN - 0006-2960, 0006-2960 KW - double prime S4 protein KW - Microbiology Abstracts B: Bacteriology KW - ^AS4 protein KW - Bacillus stearothermophilus KW - Ribosomal proteins KW - N.M.R. KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17746811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structural+Preordering+in+the+N-Terminal+Region+of+Ribosomal+Protein+S4+Revealed+by+Heteronuclear+NMR+Spectroscopy&rft.au=Sayers%2C+E+W%3BGerstner%2C+R+B%3BDraper%2C+DE%3BTorchia%2C+DA&rft.aulast=Sayers&rft.aufirst=E&rft.date=2000-11-01&rft.volume=39&rft.issue=44&rft.spage=13602&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bacillus stearothermophilus; Ribosomal proteins; N.M.R. ER - TY - JOUR T1 - Solution structure of the phosphoryl transfer complex between the signal transducing proteins HPr and IIA super(Glucose) of the Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system AN - 17740299; 4809133 AB - The solution structure of the second protein-protein complex of the Escherichia coli phosphoenolpyruvate: sugar phosphotransferase system, that between histidine-containing phosphocarrier protein (HPr) and glucose-specific enzyme IIA super(Glucose) (IIA super(Glc)), has been determined by NMR spectroscopy, including the use of dipolar couplings to provide long-range orientational information and newly developed rigid body minimization and constrained/restrained simulated annealing methods. A protruding convex surface on HPr interacts with a complementary concave depression on IIA super(Glc). Both binding surfaces comprise a central hydrophobic core region surrounded by a ring of polar and charged residues, positive for HPr and negative for IIA super(Glc). Formation of the unphosphorylated complex, as well as the phosphorylated transition state, involves little or no change in the protein backbones, but there are conformational rearrangements of the interfacial side chains. Both HPr andIA super(Glc) recognize a variety of structurally diverse proteins. Comparisons with the structures of the enzyme I-HPr and IIA super(Glc)- glycerol kinase complexes reveal how similar binding surfaces can be formed with underlying backbone scaffolds that are structurally dissimilar and highlight the role of redundancy and side chain conformational plasticity. JF - EMBO Journal AU - Wang, G AU - Louis, J M AU - Sondej, M AU - Seok, Y AU - Peterkofsky, A AU - Clore, G M AD - Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0510, clore@speck.niddk.nih.gov Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 5635 EP - 5649 VL - 19 IS - 21 SN - 0261-4189, 0261-4189 KW - Hpr protein KW - histidine-containing phosphocarrier protein KW - phosphoenolpyruvate-sugar phosphotransferase KW - Microbiology Abstracts B: Bacteriology KW - Glucose KW - Glycerol kinase KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17740299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Solution+structure+of+the+phosphoryl+transfer+complex+between+the+signal+transducing+proteins+HPr+and+IIA+super%28Glucose%29+of+the+Escherichia+coli+phosphoenolpyruvate%3Asugar+phosphotransferase+system&rft.au=Wang%2C+G%3BLouis%2C+J+M%3BSondej%2C+M%3BSeok%2C+Y%3BPeterkofsky%2C+A%3BClore%2C+G+M&rft.aulast=Wang&rft.aufirst=G&rft.date=2000-11-01&rft.volume=19&rft.issue=21&rft.spage=5635&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Glucose; Glycerol kinase ER - TY - JOUR T1 - Bacteremia and Skin/Bone Infections in Two Patients with X-Linked Agammaglobulinemia Caused by an Unusual Organism Related to Flexispira/Helicobacter Species AN - 17738138; 4805329 AB - Two patients with Bruton's X-linked agammaglobulinemia are described with bacteremia and skin/bone infection due to an organism which by 16S rRNA gene sequence analysis was most closely related to "Flexispira" rappini (and thus designated a Flexispira-like organism, FLO) and more distantly related to the Helicobacter species. The organism required microaerobic conditions and, supplemental H sub(2) gas for growth and was reliably stained with acridine orange. In common with Helicobacter cinaedi infections, the focus of the FLO infection was in one case in the blood vessels or lymphatics of an extremity and in the other case in the skin and adjacent bone of an extremity. In both cases, prolonged IV antibiotic therapy was necessary to clear the infection. The susceptibility of XLA patients to FLO infection appears to be related to the fact that XLA is associated with severe B cell (humoral) immunodeficiency and thus these patients have difficulty with intravascular or intralymphatic infection. These findings elucidate the nature of FLO infections in humans and point the way to their detection and treatment. JF - Clinical Immunology AU - Cuccherini, B AU - Chua, K AU - Gill, V AU - Weir, S AU - Wray, B AU - Stewart, D AU - Nelson, D AU - Fuss, I AU - Strober, W AD - Mucosal Immunity Section, Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 121 EP - 129 VL - 97 IS - 2 SN - 1521-6616, 1521-6616 KW - immunology KW - man KW - Flexispira KW - Helicobacter KW - Helicobacter cinaedi KW - agammaglobulinemia KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Skin KW - Lymphocytes B KW - X chromosome KW - Immunodeficiency KW - Bacteremia KW - Antibiotics KW - Bone KW - Blood vessels KW - Flexispira rappini KW - F 06858:Antibody KW - J 02843:Skin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17738138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Immunology&rft.atitle=Bacteremia+and+Skin%2FBone+Infections+in+Two+Patients+with+X-Linked+Agammaglobulinemia+Caused+by+an+Unusual+Organism+Related+to+Flexispira%2FHelicobacter+Species&rft.au=Cuccherini%2C+B%3BChua%2C+K%3BGill%2C+V%3BWeir%2C+S%3BWray%2C+B%3BStewart%2C+D%3BNelson%2C+D%3BFuss%2C+I%3BStrober%2C+W&rft.aulast=Cuccherini&rft.aufirst=B&rft.date=2000-11-01&rft.volume=97&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Clinical+Immunology&rft.issn=15216616&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Helicobacter; Flexispira rappini; Skin; Bone; Immunodeficiency; Lymphocytes B; Bacteremia; X chromosome; Antibiotics; Blood vessels ER - TY - JOUR T1 - Towards a quantitative free flow electrophoresis and its application to particle size separations AN - 17724754; 4794091 AB - The possibility to quantify free-flow electrophoresis (FFE) data was explored in application to 6 negatively charged polystyrene size standards in the size range of 73 to 762 nm diameter. Peak fraction numbers in FFE were shown to be proportional to mobilities of the particles, determined by capillary zone electrophoresis in the identical buffer. Standard deviations of peak fraction numbers demonstrate a high degree of intra-experimental reproducibility while inter-experimentally, a variability of 1 to 5 peak fraction numbers within 28 fractions was found. A relative mobility (R sub(f)) scale for peak identification in FFE based on the free mobility of the dye, SPADNS, allowed for the utilization of the entire electrophoretic migration path but failed to improve the precision of fraction numbers in view of the substantial zone spreading of the dye. Mobility differences between particles increased upon lowering the ionic strength of the electrophoretic buffer. Peak width increased with particle size in inverse relation to ionic strength. JF - Preparative Biochemistry and Biotechnology AU - Martynov, A AU - Schepkina, J AU - Chestkov, V AU - Radko, S P AU - Kolosova, I AU - Chrambach, A AD - Section on Macromolecular Analysis, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1850, USA Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 331 EP - 341 VL - 30 IS - 4 SN - 1082-6068, 1082-6068 KW - polystyrene KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Electrophoresis KW - Dyes KW - Buffers KW - W2 32250:Others KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17724754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Preparative+Biochemistry+and+Biotechnology&rft.atitle=Towards+a+quantitative+free+flow+electrophoresis+and+its+application+to+particle+size+separations&rft.au=Martynov%2C+A%3BSchepkina%2C+J%3BChestkov%2C+V%3BRadko%2C+S+P%3BKolosova%2C+I%3BChrambach%2C+A&rft.aulast=Martynov&rft.aufirst=A&rft.date=2000-11-01&rft.volume=30&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Preparative+Biochemistry+and+Biotechnology&rft.issn=10826068&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Electrophoresis; Buffers; Dyes ER - TY - JOUR T1 - Resistance to multiple fluoroquinolones in a clinical isolate of Streptococcus pyogenes: identification of gyrA and parC and specification of point mutations associated with resistance AN - 17646787; 4795110 AB - A strain of Streptococcus pyogenes resistant to multiple fluoroquinolones was isolated from the blood of an immunocompromised patient. Resistance to fluoroquinolones in S. pyogenes has not been previously studied. Compared to 10 sensitive strains of S. pyogenes, the fluoroquinolone-resistant clinical isolate of S. pyogenes presented point mutations in gyrA, predicting that serine-81 was changed to phenylalanine and that methionine-99 was changed to leucine, and in parC, predicting that serine-79 was changed to tyrosine. The mechanism of fluoroquinolone resistance in this isolate of S. pyogenes appears to be analogous to previously reported mechanisms for Streptococcus pneumoniae. JF - Antimicrobial Agents & Chemotherapy AU - Yan, S S AU - Fox, M L AU - Holland, S M AU - Stock, F AU - Gill, V J AU - Fedorko, D P AD - Microbiology Service, CPD, Clinical Center, National Institutes of Health, Building 10, Rm. 2C385, Bethesda, MD 20892-1508, USA, dfedorko@mail.cc.nih.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 3196 EP - 3198 VL - 44 IS - 11 SN - 0066-4804, 0066-4804 KW - gyrA gene KW - parC gene KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus pneumoniae KW - Drug resistance KW - Point mutation KW - Quinolones KW - Antibacterial agents KW - Streptococcus pyogenes KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17646787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Resistance+to+multiple+fluoroquinolones+in+a+clinical+isolate+of+Streptococcus+pyogenes%3A+identification+of+gyrA+and+parC+and+specification+of+point+mutations+associated+with+resistance&rft.au=Yan%2C+S+S%3BFox%2C+M+L%3BHolland%2C+S+M%3BStock%2C+F%3BGill%2C+V+J%3BFedorko%2C+D+P&rft.aulast=Yan&rft.aufirst=S&rft.date=2000-11-01&rft.volume=44&rft.issue=11&rft.spage=3196&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.44.11.3196-3198.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pyogenes; Streptococcus pneumoniae; Antibacterial agents; Quinolones; Drug resistance; Point mutation DO - http://dx.doi.org/10.1128/AAC.44.11.3196-3198.2000 ER - TY - JOUR T1 - Identification of polymorphonuclear leukocyte and HL-60 cell receptors for adhesins of Streptococcus gordonii and Actinomyces naeslundii AN - 17642255; 4795210 AB - Interactions of oral streptococci and actinomyces with polymorphonuclear leukocytes (PMNs), mediated by sialic acid- and Gal/GalNAc-reactive adhesins, respectively, result in activation of the PMNs and thereby may contribute to the initiation of oral inflammation. Sialidase treatment of PMNs or HL-60 cells abolished adhesion of Streptococcus gordonii but was required for adhesion of Actinomyces naeslundii. The same effects of sialidase were noted for adhesion of these bacteria to a major 150-kDa surface glycoprotein of either PMNs or undifferentiated HL-60 cells and to a 130-kDa surface glycoprotein of differentiated HL-60 cells. These glycoproteins were both identified as leukosialin (CD43) by immunoprecipitation with a specific monoclonal antibody (MAb). Adhesion of streptococci and actinomyces to a 200-kDa minor PMN surface glycoprotein was also detected by bacterial overlay of untreated and sialidase-treated nitrocellulose transfers, respectively. This glycoprotein was identified as leukocyte common antigen (CD45) by immunoprecipitation with a specific MAb. CD43 and CD45 both possess extracellular mucinlike domains in addition to intracellular domains that are implicated in signal transduction. Consequently, the interactions of streptococci and actinomyces with the mucinlike domains of these mammalian cell surface glycoproteins result not only in adhesion but, in addition, may represent the initial step in PMN activation by these bacteria. JF - Infection and Immunity AU - Ruhl, S AU - Cisar, JO AU - Sandberg, AL AD - Building 45, Room 4AN-24A, NIH, Bethesda, MD 20892, USA, ann.sandberg@nih.gov Y1 - 2000/11// PY - 2000 DA - Nov 2000 SP - 6346 EP - 6354 VL - 68 IS - 11 SN - 0019-9567, 0019-9567 KW - Leukosialin KW - Sialidase KW - Microbiology Abstracts B: Bacteriology KW - Adhesins KW - HeLa cells KW - Streptococcus gordonii KW - Host-pathogen interactions KW - Leukocytes (polymorphonuclear) KW - Glycoproteins KW - Actinomyces naeslundii KW - Signal transduction KW - J 02832:Antigenic properties and virulence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17642255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+of+polymorphonuclear+leukocyte+and+HL-60+cell+receptors+for+adhesins+of+Streptococcus+gordonii+and+Actinomyces+naeslundii&rft.au=Ruhl%2C+S%3BCisar%2C+JO%3BSandberg%2C+AL&rft.aulast=Ruhl&rft.aufirst=S&rft.date=2000-11-01&rft.volume=68&rft.issue=11&rft.spage=6346&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.68.11.6346-6354.2000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus gordonii; Actinomyces naeslundii; HeLa cells; Leukocytes (polymorphonuclear); Adhesins; Glycoproteins; Signal transduction; Host-pathogen interactions DO - http://dx.doi.org/10.1128/IAI.68.11.6346-6354.2000 ER - TY - JOUR T1 - Nonviral Skin Gene Therapy AN - 17640495; 4794489 AB - Nonviral skin gene therapy is an effective method to directly deliver and transiently express genes in the skin. Several different nonviral delivery methods have been successfully used and are analyzed here for their efficiency and efficacy in achieving specific therapeutic applications. For one important and frequently used application of nonviral skin gene therapy, genetic immunization, the types of resulting immune responses (Th1 versus Th2) will depend on which delivery method is used. In addition, we discuss the contributions of DNA as an immunostimulatory adjuvant in genetic immunization and how activation of skin dendritic cells and induction of IL-12 expression are mechanistically important in this process. Nonviral skin gene therapy has also been successfully used to enhance tumor regression in animal models, frequently by inducing a specific immune response against the tumor. In the future, nonviral skin gene therapy may be successfully used for the treatment of additional skin diseases if genes can be selectively delivered and expressed in specific skin cells, and if increased level and duration of gene expression can be achieved. JF - Human Gene Therapy AU - Vogel, J C AD - Dermatology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm. 12N260, Bethesda, MD 20892-1904, USA Y1 - 2000/11/01/ PY - 2000 DA - 2000 Nov 01 SP - 2253 EP - 2259 VL - 11 IS - 16 SN - 1043-0342, 1043-0342 KW - animal models KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Interleukin 12 KW - Skin KW - Gene therapy KW - Reviews KW - Tumors KW - Immune response KW - G 07443:Gene therapy KW - W3 33000:General topics and reviews KW - W 30965:Miscellaneous, Reviews KW - W3 33180:Gene based (protocols, clinical trials, and animal models) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17640495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Nonviral+Skin+Gene+Therapy&rft.au=Vogel%2C+J+C&rft.aulast=Vogel&rft.aufirst=J&rft.date=2000-11-01&rft.volume=11&rft.issue=16&rft.spage=2253&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2F104303400750035780 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Gene therapy; Skin; Interleukin 12; Immune response; Tumors; Reviews DO - http://dx.doi.org/10.1089/104303400750035780 ER - TY - JOUR T1 - Pseudosubstrate inhibition of protein kinase PKR by swine pox virus C8L gene product. AN - 72348335; 11040133 AB - The interferon-induced protein kinase PKR is activated upon binding double-stranded RNA and phosphorylates the translation initiation factor eIF2alpha on Ser-51 to inhibit protein synthesis in virally infected cells. Swinepox virus C8L and vaccinia virus K3L gene products structurally resemble the amino-terminal third of eIF2alpha. We demonstrate that the C8L protein, like the K3L protein, can reverse the toxic effects caused by high level expression of human PKR in yeast cells. In addition, expression of either the K3L or C8L gene product was found to reverse the inhibition of reporter gene translation caused by PKR expression in mammalian cells. The inhibitory function of the K3L and C8L gene products in these assays was found to be critically dependent on residues near the carboxyl-termini of the proteins including a sequence motif shared among eIF2alpha and the C8L and K3L gene products. Thus, despite significant sequence differences both the C8L and K3L proteins function as pseudosubstrate inhibitors of PKR. Copyright 2000 Academic Press. JF - Virology AU - Kawagishi-Kobayashi, M AU - Cao, C AU - Lu, J AU - Ozato, K AU - Dever, T E AD - Laboratory of Eukaryotic Gene Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland, 20892-2716, USA. Y1 - 2000/10/25/ PY - 2000 DA - 2000 Oct 25 SP - 424 EP - 434 VL - 276 IS - 2 SN - 0042-6822, 0042-6822 KW - C8L protein, Swinepox virus KW - 0 KW - Enzyme Inhibitors KW - Eukaryotic Initiation Factor-2 KW - Viral Proteins KW - pK3 protein, Vaccinia virus KW - Luciferases KW - EC 1.13.12.- KW - eIF-2 Kinase KW - EC 2.7.11.1 KW - Index Medicus KW - 3T3 Cells KW - Animals KW - Protein Biosynthesis KW - Amino Acid Sequence KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Phosphorylation KW - Transfection KW - Eukaryotic Initiation Factor-2 -- metabolism KW - Molecular Sequence Data KW - Enzyme Inhibitors -- metabolism KW - Gene Expression Regulation KW - Substrate Specificity KW - Sequence Homology, Amino Acid KW - Luciferases -- genetics KW - Viral Proteins -- genetics KW - Suipoxvirus -- metabolism KW - eIF-2 Kinase -- metabolism KW - Suipoxvirus -- genetics KW - Viral Proteins -- chemistry KW - Viral Proteins -- metabolism KW - eIF-2 Kinase -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72348335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Pseudosubstrate+inhibition+of+protein+kinase+PKR+by+swine+pox+virus+C8L+gene+product.&rft.au=Kawagishi-Kobayashi%2C+M%3BCao%2C+C%3BLu%2C+J%3BOzato%2C+K%3BDever%2C+T+E&rft.aulast=Kawagishi-Kobayashi&rft.aufirst=M&rft.date=2000-10-25&rft.volume=276&rft.issue=2&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-21 N1 - Date created - 2000-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A regulatory role for ADP-ribosylation factor 6 (ARF6) in activation of the phagocyte NADPH oxidase. AN - 72339405; 10931844 AB - In activated neutrophils NADPH oxidase is regulated through various signaling intermediates, including heterotrimeric G proteins, kinases, GTPases, and phospholipases. ADP-ribosylation factor (ARF) describes a family of GTPases associated with phospholipase D (PLD) activation. PLD is implicated in NADPH oxidase activation, although it is unclear whether activation of PLD by ARF is linked to receptor-mediated oxidase activation. We explored whether ARF participates in NADPH oxidase activation by formyl-methionine-leucine-phenylalanine (fMLP) and whether this involves PLD. Using multicolor forward angle light scattering analyses to measure superoxide production in differentiated neutrophil-like PLB-985 cells, we tested enhanced green fluorescent fusion proteins of wild-type ARF1 or ARF6, or their mutant counterparts. The ARF6(Q67L) mutant defective in GTP hydrolysis caused increased superoxide production, whereas the ARF6(T27N) mutant defective in GTP binding caused diminished responses to fMLP. The ARF1 mutants had no effect on fMLP responses, and none of the ARF proteins affected phorbol 12-myristate 13-acetate-elicited oxidase activity. PLD inhibitors 1-butanol and 2, 3-diphosphoglycerate, or the ARF6(N48R) mutant assumed to be defective in PLD activation, blocked fMLP-elicited oxidase activity in transfected cells. The data suggest that ARF6 but not ARF1 modulates receptor-mediated NADPH oxidase activation in a PLD-dependent mechanism. Because PMA-elicited NADPH oxidase activation also appears to be PLD-dependent, but ARF-independent, ARF6 and protein kinase C may act through distinct pathways, both involving PLD. JF - The Journal of biological chemistry AU - Dana, R R AU - Eigsti, C AU - Holmes, K L AU - Leto, T L AD - Laboratory of Host Defenses and the Flow Cytometry Section, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/10/20/ PY - 2000 DA - 2000 Oct 20 SP - 32566 EP - 32571 VL - 275 IS - 42 SN - 0021-9258, 0021-9258 KW - CYBB protein, human KW - 0 KW - Membrane Glycoproteins KW - Recombinant Fusion Proteins KW - Recombinant Proteins KW - Bucladesine KW - 63X7MBT2LQ KW - NADPH Oxidase KW - EC 1.6.3.1 KW - ADP-Ribosylation Factor 1 KW - EC 3.6.5.2 KW - ADP-Ribosylation Factors KW - ADP-ribosylation factor 6 KW - Index Medicus KW - Enzyme Activation KW - Humans KW - Cell Differentiation KW - Membrane Glycoproteins -- analysis KW - Bucladesine -- pharmacology KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Transfection KW - Recombinant Proteins -- metabolism KW - ADP-Ribosylation Factor 1 -- metabolism KW - Luminescent Measurements KW - Respiratory Burst KW - Flow Cytometry KW - Recombinant Proteins -- chemistry KW - Cell Line KW - Membrane Glycoproteins -- metabolism KW - NADPH Oxidase -- metabolism KW - NADPH Oxidase -- chemistry KW - Granulocytes -- enzymology KW - Phagocytes -- enzymology KW - Granulocytes -- physiology KW - Granulocytes -- drug effects KW - NADPH Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72339405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=A+regulatory+role+for+ADP-ribosylation+factor+6+%28ARF6%29+in+activation+of+the+phagocyte+NADPH+oxidase.&rft.au=Dana%2C+R+R%3BEigsti%2C+C%3BHolmes%2C+K+L%3BLeto%2C+T+L&rft.aulast=Dana&rft.aufirst=R&rft.date=2000-10-20&rft.volume=275&rft.issue=42&rft.spage=32566&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-20 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clastogenic effect of the human T-cell leukemia virus type I Tax oncoprotein correlates with unstabilized DNA breaks. AN - 72336224; 10969065 AB - Expression of the human T-cell leukemia virus type I (HTLV-I) Tax oncoprotein rapidly engenders DNA damage as reflected in a significant increase of micronuclei (MN) in cells. To understand better this phenomenon, we have investigated the DNA content of MN induced by Tax. Using an approach that we termed FISHI, fluorescent in situ hybridization and incorporation, we attempted to characterize MN with centric or acentric DNA fragments for the presence or absence of free 3'-OH ends. Free 3'-OH ends were defined as those ends accessible to in situ addition of digoxigenin-dUTP using terminal deoxynucleotidyl transferase. MN were also assessed for centromeric sequences using standard fluorescent in situ hybridization (FISH). Combining these results, we determined that Tax oncoprotein increased the frequency of MN containing centric DNA with free 3'-OH and decreased the frequency of MN containing DNA fragments that had incorporation-inaccessible 3'-ends. Recently, it has been suggested that intracellular DNA breaks without detectable 3'-OH ends are stabilized by the protective addition of telomeric caps, while breaks with freely detectable 3'-OH are uncapped and are labile to degradation, incomplete replication, and loss during cell division. Accordingly, based on increased detection of free 3'-OH-containing DNA fragments, we concluded that HTLV-I Tax interferes with protective cellular mechanism(s) used normally for stabilizing DNA breaks. JF - The Journal of biological chemistry AU - Majone, F AU - Jeang, K T AD - Department of Biology, University of Padova, Padova 35131 Italy and the Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA. majone@civ.bio.unipd.it Y1 - 2000/10/20/ PY - 2000 DA - 2000 Oct 20 SP - 32906 EP - 32910 VL - 275 IS - 42 SN - 0021-9258, 0021-9258 KW - Gene Products, tat KW - 0 KW - Mutagens KW - Oligodeoxyribonucleotides KW - Oligonucleotide Probes KW - Index Medicus KW - Centromere -- genetics KW - Cell Nucleus -- ultrastructure KW - HeLa Cells KW - Models, Molecular KW - Humans KW - Telomere -- ultrastructure KW - Telomere -- genetics KW - In Situ Hybridization, Fluorescence KW - Interphase KW - Nucleic Acid Conformation KW - Centromere -- ultrastructure KW - Base Sequence KW - Micronucleus Tests KW - Molecular Sequence Data KW - Human T-lymphotropic virus 1 -- genetics KW - DNA Damage KW - Gene Products, tat -- metabolism KW - Gene Products, tat -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72336224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Clastogenic+effect+of+the+human+T-cell+leukemia+virus+type+I+Tax+oncoprotein+correlates+with+unstabilized+DNA+breaks.&rft.au=Majone%2C+F%3BJeang%2C+K+T&rft.aulast=Majone&rft.aufirst=F&rft.date=2000-10-20&rft.volume=275&rft.issue=42&rft.spage=32906&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-20 N1 - Date created - 2000-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis. AN - 72358442; 11042693 AB - Deregulation of E2F transcriptional control has been implicated in oncogenic transformation. Consistent with this idea, we recently demonstrated that during hepatocarcinogenesis in c-myc/TGFalpha double transgenic mice, there is increased expression of E2F-1 and E2F-2, as well as induction of putative E2F target genes. Therefore, we generated transgenic mice expressing E2F-1 under the control of the albumin enhancer/promoter to test the hypothesis that E2F family members may contribute to liver tumor development. Overexpression of E2F-1 resulted in mild but persistent increases in cell proliferation and death during postnatal liver growth, and no increases in hepatic regenerative growth in response to partial hepatectomy. Nevertheless, from 2 months postnatally E2F-1 transgenic mice exhibited prominent hepatic histological abnormalities including preneoplastic foci adjacent to portal tracts and pericentral large cell dysplasia. From 6 to 8 months onward, there was an abrupt increase in the number of neoplastic nodules ('adenomas') with 100% incidence by 10 months. Some adenomas showed evidence of malignant transformation, and two of six mice killed at 12 months showed trabecular hepatocellular carcinoma. Endogenous c-myc was up-regulated in the early stages of E2F-1 hepatocarcinogenesis, whereas p53 was overexpressed in the tumors, suggesting that both E2F-1-mediated proliferation and apoptosis are operative but at different stages of hepatocarcinogenesis. In conclusion, E2F-1 overexpression in the liver causes dysplasia and tumors and suggests a cooperation between E2F-1 and c-myc oncogenes during liver oncogenesis. JF - Oncogene AU - Conner, E A AU - Lemmer, E R AU - Omori, M AU - Wirth, P J AU - Factor, V M AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, MD 20892, USA. Y1 - 2000/10/19/ PY - 2000 DA - 2000 Oct 19 SP - 5054 EP - 5062 VL - 19 IS - 44 SN - 0950-9232, 0950-9232 KW - Albumins KW - 0 KW - Arid4a protein, mouse KW - Carrier Proteins KW - Cell Cycle Proteins KW - DNA-Binding Proteins KW - E2F Transcription Factors KW - E2F1 Transcription Factor KW - E2F1 protein, human KW - E2F2 Transcription Factor KW - E2F2 protein, human KW - E2f1 protein, mouse KW - Proto-Oncogene Proteins c-myc KW - Retinoblastoma-Binding Protein 1 KW - Transcription Factor DP1 KW - Transcription Factors KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Tumor Suppressor Protein p53 -- physiology KW - Apoptosis -- physiology KW - Humans KW - Cell Division -- physiology KW - Liver -- metabolism KW - Mice, Transgenic KW - Liver -- physiology KW - Proto-Oncogene Proteins c-myc -- biosynthesis KW - Gene Expression Regulation, Neoplastic KW - Precancerous Conditions -- genetics KW - Promoter Regions, Genetic -- genetics KW - Hepatocytes -- cytology KW - Liver Regeneration -- physiology KW - Tumor Suppressor Protein p53 -- genetics KW - Genes, myc -- genetics KW - Male KW - Tumor Suppressor Protein p53 -- biosynthesis KW - Liver -- pathology KW - Albumins -- genetics KW - Proto-Oncogene Proteins c-myc -- genetics KW - Mice KW - Precancerous Conditions -- metabolism KW - Mice, Inbred CBA KW - Enhancer Elements, Genetic -- genetics KW - Mice, Inbred C57BL KW - Crosses, Genetic KW - Hepatocytes -- physiology KW - Female KW - Hepatocytes -- metabolism KW - Transcription Factors -- physiology KW - Liver Neoplasms, Experimental -- genetics KW - Liver Neoplasms, Experimental -- pathology KW - Liver Neoplasms, Experimental -- metabolism KW - Cell Transformation, Neoplastic -- metabolism KW - Transcription Factors -- genetics KW - Transcription Factors -- biosynthesis KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72358442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Dual+functions+of+E2F-1+in+a+transgenic+mouse+model+of+liver+carcinogenesis.&rft.au=Conner%2C+E+A%3BLemmer%2C+E+R%3BOmori%2C+M%3BWirth%2C+P+J%3BFactor%2C+V+M%3BThorgeirsson%2C+S+S&rft.aulast=Conner&rft.aufirst=E&rft.date=2000-10-19&rft.volume=19&rft.issue=44&rft.spage=5054&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-30 N1 - Date created - 2000-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residue R216 and catalytic efficiency of a murine class alpha glutathione S-transferase toward benzo[a]pyrene 7(R),8(S)-diol 9(S), 10(R)-epoxide. AN - 72319743; 11027134 AB - Murine class alpha glutathione S-transferase A1-1 (mGSTA1-1), unlike mammalian class alpha GSTs, is the most efficient in the glutathione (GSH) conjugation of the ultimate carcinogenic metabolite of benzo[a]pyrene, (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9, 10-tetrahydrobenzo[a]pyrene [(+)-anti-BPDE] [Hu, X., Srivastava, S. K., Xia, H., Awasthi, Y. C., and Singh, S. V. (1996) J. Biol. Chem. 271, 32684-32688]. Here, we report the crystal structures of mGSTA1-1 in complex with GSH and with the GSH conjugate of (+)-anti-BPDE (GSBpd) at 1.9 and 2.0 A resolution, respectively. Both crystals belong to monoclinic space group C2 with one dimer in the asymmetric unit. The structures reveal that, within one subunit, the GSH moiety interacts with residues Y8, R14, K44, Q53, V54, Q66, and T67, whereas the hydrophobic moiety of GSBpd interacts with the side chains of F9, R14, M207, A215, R216, F219, and I221. In addition, the GSH moiety interacts with D100 and R130 from the other subunit across the dimer interface. The structural comparison between mGSTA1-1.GSH and mGSTA1-1.GSBpd reveals significant conformational differences. The movement of helix alpha9 brings the residues on the helix into direct interaction with the product. Most noticeable are the positional displacement and conformational change of R216, one of the residues located in helix alpha9. The side chain of R216, which points away from the H-site in the mGSTA1-1.GSH complex, probes into the active site and becomes parallel with the aromatic ring system of GSBpd. Moreover, the guanidinium group of R216 shifts approximately 8 A and forms a strong hydrogen bond with the C8 hydroxyl group of GSBpd, suggesting that the electrostatic assistance provided by the guanidinium group facilitates the ring-opening reaction of (+)-anti-BPDE. The structure of mGSTA1-1. GSBpd is also compared with those of hGSTP1-1[V104,A113].GSBpd, hGSPA1-1.S-benzylglutathione, and mGSTA4-4. 4-S-glutathionyl-5-pentyltetrahydrofuran-2-ol. The comparison provides further evidence that supports the functional roles of R216 and helix alpha9. The lack of mobility of helix alpha9 and/or the lack of electrostatic assistance from R216 may be responsible for the relatively lower activity of hGSTA1-1, mGSTA4-4, and hGSTP1-1 toward (+)-anti-BPDE. JF - Biochemistry AU - Gu, Y AU - Singh, S V AU - Ji, X AD - Program in Structural Biology, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA. Y1 - 2000/10/17/ PY - 2000 DA - 2000 Oct 17 SP - 12552 EP - 12557 VL - 39 IS - 41 SN - 0006-2960, 0006-2960 KW - Carcinogens KW - 0 KW - Isoenzymes KW - Xenobiotics KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - Arginine KW - 94ZLA3W45F KW - GSTP1 protein, human KW - EC 2.5.1.18 KW - Glutathione S-Transferase pi KW - Glutathione Transferase KW - Gstp1 protein, mouse KW - glutathione S-transferase alpha KW - Index Medicus KW - Software KW - Animals KW - Protein Structure, Secondary KW - Computer Simulation KW - Models, Molecular KW - Xenobiotics -- metabolism KW - Humans KW - Mice KW - Protein Conformation -- drug effects KW - Xenobiotics -- chemistry KW - Binding Sites KW - Crystallography, X-Ray KW - Substrate Specificity KW - Protein Structure, Tertiary KW - Catalysis KW - Isoenzymes -- chemistry KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- metabolism KW - Carcinogens -- metabolism KW - Arginine -- metabolism KW - Arginine -- chemistry KW - Carcinogens -- chemistry KW - Glutathione Transferase -- metabolism KW - Glutathione Transferase -- chemistry KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- chemistry KW - Isoenzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72319743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Residue+R216+and+catalytic+efficiency+of+a+murine+class+alpha+glutathione+S-transferase+toward+benzo%5Ba%5Dpyrene+7%28R%29%2C8%28S%29-diol+9%28S%29%2C+10%28R%29-epoxide.&rft.au=Gu%2C+Y%3BSingh%2C+S+V%3BJi%2C+X&rft.aulast=Gu&rft.aufirst=Y&rft.date=2000-10-17&rft.volume=39&rft.issue=41&rft.spage=12552&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-07 N1 - Date created - 2000-11-07 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 1F3A; PDB; 1F3B N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor. AN - 72340928; 11032796 AB - GAF domains are ubiquitous motifs present in cyclic GMP (cGMP)-regulated cyclic nucleotide phosphodiesterases, certain adenylyl cyclases, the bacterial transcription factor FhlA, and hundreds of other signaling and sensory proteins from all three kingdoms of life. The crystal structure of the Saccharomyces cerevisiae YKG9 protein was determined at 1.9 A resolution. The structure revealed a fold that resembles the PAS domain, another ubiquitous signaling and sensory transducer. YKG9 does not bind cGMP, but the isolated first GAF domain of phosphodiesterase 5 binds with K:(d) = 650 nM. The cGMP binding site of the phosphodiesterase GAF domain was identified by homology modeling and site-directed mutagenesis, and consists of conserved Arg, Asn, Lys and Asp residues. The structural and binding studies taken together show that the cGMP binding GAF domains form a new class of cyclic nucleotide receptors distinct from the regulatory domains of cyclic nucleotide-regulated protein kinases and ion channels. JF - The EMBO journal AU - Ho, Y S AU - Burden, L M AU - Hurley, J H AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0580, USA. Y1 - 2000/10/16/ PY - 2000 DA - 2000 Oct 16 SP - 5288 EP - 5299 VL - 19 IS - 20 SN - 0261-4189, 0261-4189 KW - Bacterial Proteins KW - 0 KW - Carrier Proteins KW - Contractile Proteins KW - Fungal Proteins KW - Intracellular Signaling Peptides and Proteins KW - Microfilament Proteins KW - Photoreceptors, Microbial KW - Profilins KW - Recombinant Proteins KW - Saccharomyces cerevisiae Proteins KW - YKL069W protein, S cerevisiae KW - cyclic GMP-binding protein KW - photoactive yellow protein, Bacteria KW - Phosphoric Diester Hydrolases KW - EC 3.1.4.- KW - PDE5 protein, S cerevisiae KW - EC 3.1.4.17 KW - Cyclic Nucleotide Phosphodiesterases, Type 5 KW - EC 3.1.4.35 KW - Cyclic GMP KW - H2D2X058MU KW - Index Medicus KW - Protein Structure, Secondary KW - Models, Molecular KW - Amino Acid Sequence KW - Fungal Proteins -- genetics KW - Recombinant Proteins -- genetics KW - Protein Binding KW - Phosphoric Diester Hydrolases -- chemistry KW - Binding Sites KW - Mutagenesis, Site-Directed KW - Fungal Proteins -- chemistry KW - Cyclic GMP -- metabolism KW - Fungal Proteins -- metabolism KW - Sequence Alignment KW - Amino Acid Motifs KW - Bacterial Proteins -- chemistry KW - Microfilament Proteins -- chemistry KW - Recombinant Proteins -- metabolism KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Recombinant Proteins -- chemistry KW - Protein Structure, Tertiary KW - Saccharomyces cerevisiae -- genetics KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- chemistry KW - Carrier Proteins -- genetics KW - Saccharomyces cerevisiae -- chemistry KW - Signal Transduction KW - Carrier Proteins -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72340928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=Structure+of+the+GAF+domain%2C+a+ubiquitous+signaling+motif+and+a+new+class+of+cyclic+GMP+receptor.&rft.au=Ho%2C+Y+S%3BBurden%2C+L+M%3BHurley%2C+J+H&rft.aulast=Ho&rft.aufirst=Y&rft.date=2000-10-16&rft.volume=19&rft.issue=20&rft.spage=5288&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-28 N1 - Date created - 2000-11-28 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 1F5M; PDB; 1FL4 N1 - SuppNotes - Cited By: Annu Rev Biochem. 1999;68:127-55 [10872446] Trends Biochem Sci. 1997 Dec;22(12):458-9 [9433123] Acta Crystallogr D Biol Crystallogr. 2000 Feb;56(Pt 2):232-7 [10666615] Nature. 1981 Apr 30;290(5809):744-9 [6261152] Biochemistry. 1989 Jul 11;28(14):6122-7 [2550070] Proc Natl Acad Sci U S A. 1990 Jan;87(1):288-92 [2153290] J Biol Chem. 1990 Sep 5;265(25):14964-70 [1697584] J Biol Chem. 1990 Sep 25;265(27):16031-4 [2168874] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] J Biol Chem. 1991 Jun 15;266(17):10711-4 [1710212] Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9868-72 [1719541] J Biol Chem. 1991 Dec 15;266(35):23802-9 [1721055] Biochemistry. 1992 May 19;31(19):4643-9 [1316156] Biochem J. 1998 Feb 1;329 ( Pt 3):505-10 [9445376] Nature. 1998 Mar 12;392(6672):206-9 [9515969] Nature. 1998 Apr 30;392(6679):871-4 [9582067] Proc Natl Acad Sci U S A. 1998 May 26;95(11):5857-64 [9600884] Proc Natl Acad Sci U S A. 1998 May 26;95(11):5884-90 [9600888] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8991-6 [9671792] Neuron. 1998 Jul;21(1):1-4 [9697845] J Biol Chem. 1998 Sep 18;273(38):24485-90 [9733741] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Cell. 1998 Nov 25;95(5):649-55 [9845367] Nucleic Acids Res. 1999 Jan 1;27(1):260-2 [9847196] Nature. 1998 Dec 3;396(6710):474-7 [9853756] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15177-82 [9860942] Protein Expr Purif. 1999 Feb;15(1):34-9 [10024467] J Biol Chem. 1999 May 14;274(20):13729-32 [10318772] J Mol Biol. 1999 May 28;289(1):93-101 [10339408] Biochem J. 1999 Jun 15;340 ( Pt 3):863-9 [10359674] Curr Opin Cell Biol. 2000 Apr;12(2):174-9 [10712916] J Mol Biol. 2000 Mar 10;296(5):1319-31 [10698636] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3702-7 [10725373] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7071-6 [10359840] J Biol Chem. 1999 Jun 25;274(26):18813-20 [10373499] J Biol Chem. 1999 Oct 8;274(41):29038-41 [10506154] Proteins. 1999;Suppl 3:133-40 [10526362] Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):560-5 [8570595] Science. 2000 Aug 4;289(5480):765-8 [10926536] Nature. 1993 Oct 28;365(6449):810-6 [8413665] Nat Genet. 1994 May;7(1):64-8 [8075643] Science. 1995 May 5;268(5211):675-80 [7732376] Biochemistry. 1995 May 16;34(19):6278-87 [7756254] Science. 1995 Aug 11;269(5225):807-13 [7638597] FASEB J. 1995 Oct;9(13):1319-30 [7557022] J Biol Chem. 1995 Dec 22;270(51):30671-9 [8530505] Trends Biochem Sci. 1995 Nov;20(11):478-80 [8578593] J Mol Graph. 1995 Oct;13(5):323-30, 307-8 [8603061] J Biol Chem. 1996 Sep 6;271(36):22240-4 [8703039] Science. 1996 Sep 6;273(5280):1409-12 [8703080] Methods Enzymol. 1996;269:134-48 [8791644] Curr Opin Struct Biol. 1996 Jun;6(3):377-85 [8804824] JAMA. 1996 Oct 9;276(14):1189-92 [8827977] Structure. 1997 Jan 15;5(1):19-32 [9016723] Curr Biol. 1997 Nov 1;7(11):R674-7 [9382818] Erratum In: EMBO J 2001 Mar 15;20(6):1483 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Invited commentary: on studying the joint effects of candidate genes and exposures. AN - 72367491; 11052547 JF - American journal of epidemiology AU - Umbach, D M AD - Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709-2233, USA. umbach@niehs.nih.gov Y1 - 2000/10/15/ PY - 2000 DA - 2000 Oct 15 SP - 701 EP - 703 VL - 152 IS - 8 SN - 0002-9262, 0002-9262 KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Benzene KW - J64922108F KW - Index Medicus KW - Genotype KW - Humans KW - Gestational Age KW - Confounding Factors (Epidemiology) KW - Female KW - Benzene -- adverse effects KW - Pregnancy KW - Cytochrome P-450 CYP1A1 -- genetics KW - Genetics, Population KW - Environmental Exposure KW - Genetic Predisposition to Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72367491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Invited+commentary%3A+on+studying+the+joint+effects+of+candidate+genes+and+exposures.&rft.au=Umbach%2C+D+M&rft.aulast=Umbach&rft.aufirst=D&rft.date=2000-10-15&rft.volume=152&rft.issue=8&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-13 N1 - Date created - 2000-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Am J Epidemiol. 2000 Oct 15;152(8):693-700 [11052546] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells. AN - 72347900; 11032763 AB - Toxic metals occur naturally at low concentrations throughout the environment, but are found in higher concentrations at many of the hazardous waste sites on the EPA Superfund list. As part of the Agency for Toxic Substances and Disease Registry (ATSDR) mandate to evaluate the toxicity of metals and mixtures, we chose four of the high-priority metal pollutants from ATSDR's HAZDAT list, including arsenic, cadmium, chromium, and lead, to test in a commercially developed assay system, CAT-Tox(L) (Xenometrix). This assay employs a battery of recombinant HepG2 cell lines to test the transcriptional activation capacity of xenobiotics in any of 13 different signal transduction pathways. Our specific aims were to identify metal-responsive promoters and determine whether the pattern of gene expression changed with a mixture of metals. Humic acid was used in all assays as a carrier to help solubilize the metals and, in all cases, the cells were exposed to the humic acid-metal mixture for 48 h. Humic acid alone, at 50-100 microM, showed moderate activation of the XRE promoter, but little other notable activity. As(V), at doses of 50-250 microM, produced a complex profile of activity showing significant dose-dependent induction of the hMTIIA, GST Ya, HSP70, FOS, XRE, NFkappaBRE, GADD153, p53RE, and CRE promoters. Pb(II) showed dose-related induction of the GST Ya, XRE, hMTIIA, GRP78, and CYP IA1 promoters at doses in the range of 12-100 microM. Cd(II), at 1.25-15 microM, yielded significant dose-dependent induction of hMTIIA, XRE, CYP IA1, GST Ya, HSP70, NFkappaBRE, and FOS. Whereas Cr(III) yielded small, though significant inductions of the CRE, FOS, GADD153, and XRE promoters only at the highest dose (750 microM), Cr(VI) produced significant dose-related inductions of the p53RE, FOS, NFkappaBRE, XRE, GADD45, HSP70, and CRE promoters at much lower doses, in the range of 5-10 microM. Assays testing serial dilutions of a mixture comprising 7.5 microM Cd(II), 750 microM Cr(III), and 100 microM Pb(II) (the combination of metals most frequently found at National Priority List sites) showed significant dose-dependent induction of the hMTIIA promoter, but failed to show dose-related induction of any other promoter and showed no evidence of synergistic activation of gene expression by the metals in this mixture. Our results thus show metal activation of gene expression through several previously unreported signal transduction pathways, including As(V) induction of GST Ya, FOS, XRE, NFkBRE, GADD153, p53RE, and CRE; Pb(II) induction of GST Ya, XRE, Cyp IA1, and GADD153; Cd(II) induction of NFkBRE, Cyp IA1, XRE, and GST Ya; and Cr(VI) induction of p53RE, XRE, GADD45, HSP70, and CRE promoters, and thus suggest new insights into the biochemical mechanisms of toxicity and carcinogenicity of metals. It is also an important finding that no evidence of synergistic activity was detected with the mixture of Cd(II), Cr(III), and Pb(II) tested in these assays. JF - Toxicology and applied pharmacology AU - Tully, D B AU - Collins, B J AU - Overstreet, J D AU - Smith, C S AU - Dinse, G E AU - Mumtaz, M M AU - Chapin, R E AD - Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA. tully@niehs.nih.gov Y1 - 2000/10/15/ PY - 2000 DA - 2000 Oct 15 SP - 79 EP - 90 VL - 168 IS - 2 SN - 0041-008X, 0041-008X KW - Biomarkers KW - 0 KW - Humic Substances KW - Metals, Heavy KW - Cadmium KW - 00BH33GNGH KW - Chromium KW - 0R0008Q3JB KW - Lead KW - 2P299V784P KW - Chloramphenicol O-Acetyltransferase KW - EC 2.3.1.28 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Drug Interactions KW - Chloramphenicol O-Acetyltransferase -- biosynthesis KW - Dose-Response Relationship, Drug KW - Humans KW - Transcriptional Activation -- drug effects KW - Chromium -- toxicity KW - Chloramphenicol O-Acetyltransferase -- genetics KW - Tumor Cells, Cultured KW - Lead -- toxicity KW - Signal Transduction -- drug effects KW - Cadmium -- toxicity KW - Signal Transduction -- genetics KW - Humic Substances -- pharmacology KW - Arsenic -- toxicity KW - Promoter Regions, Genetic -- drug effects KW - Promoter Regions, Genetic -- genetics KW - Metals, Heavy -- toxicity KW - Gene Expression Regulation -- drug effects KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72347900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Effects+of+arsenic%2C+cadmium%2C+chromium%2C+and+lead+on+gene+expression+regulated+by+a+battery+of+13+different+promoters+in+recombinant+HepG2+cells.&rft.au=Tully%2C+D+B%3BCollins%2C+B+J%3BOverstreet%2C+J+D%3BSmith%2C+C+S%3BDinse%2C+G+E%3BMumtaz%2C+M+M%3BChapin%2C+R+E&rft.aulast=Tully&rft.aufirst=D&rft.date=2000-10-15&rft.volume=168&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-16 N1 - Date created - 2000-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protease inhibitors stimulate hematopoiesis and decrease apoptosis and ICE expression in CD34(+) cells. AN - 72315390; 11023506 AB - Highly active retroviral therapy has been associated with a decline in the frequency of cytopenia in patients with human immunodeficiency virus (HIV) infection. This may result from lower hematologic toxicity of newer antiviral drugs and their increased efficacy against HIV-1. Protease inhibitors, in addition to their effects on HIV replication, appear to affect various cellular functions. Recently, it was reported that ritonavir inhibited caspase-1 expression in normal CD4(+) cells. It was hypothesized that protease inhibitors may improve hematopoietic function owing to their direct effects on the bone marrow progenitor cells. When ritonavir was added to methylcellulose cultures of bone marrow cells from HIV-infected patients and normal controls, colony formation increased 2.4-fold (n = 5) in control cultures and 4-fold (n = 5) in cultures of cells from HIV-infected patients. In the presence of ritonavir, cultures of CD34(+) cells showed markedly decreased apoptosis in comparison with untreated cultures (45% decrease in apoptotic cell number; n = 6). A synthetic inhibitor of caspase 1 (Ac-Tyr-Val-Ala-Asp-aldehyde [single-letter amino acid codes]), which inhibits activation of several caspases including CPP32 and interleukin 1beta-converting enzyme (ICE or caspase 1), also decreased the rate of apoptosis and enhanced colony formation by progenitor cells derived from HIV-infected patients (3-fold; n = 5). In ritonavir-treated samples derived from HIV-infected individuals, the number of cells expressing ICE also decreased. In conclusion, HIV protease inhibitors may, by blocking the caspase-dependent apoptotic pathway, overcome inhibition of hematopoiesis seen in patients with HIV infection, an effect unrelated to their antiviral activity. (Blood. 2000;96:2735-2739) JF - Blood AU - Sloand, E M AU - Maciejewski, J AU - Kumar, P AU - Kim, S AU - Chaudhuri, A AU - Young, N AD - National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-2490, USA. Y1 - 2000/10/15/ PY - 2000 DA - 2000 Oct 15 SP - 2735 EP - 2739 VL - 96 IS - 8 SN - 0006-4971, 0006-4971 KW - Cysteine Proteinase Inhibitors KW - 0 KW - HIV Protease Inhibitors KW - Oligopeptides KW - L 709049 KW - 143313-51-3 KW - Caspases KW - EC 3.4.22.- KW - Caspase 1 KW - EC 3.4.22.36 KW - Ritonavir KW - O3J8G9O825 KW - Abridged Index Medicus KW - Index Medicus KW - Cysteine Proteinase Inhibitors -- pharmacology KW - Enzyme Induction -- drug effects KW - Cells, Cultured KW - Caspases -- physiology KW - Antiretroviral Therapy, Highly Active KW - Oligopeptides -- pharmacology KW - Colony-Forming Units Assay KW - Caspase 1 -- biosynthesis KW - Hematopoiesis -- drug effects KW - Ritonavir -- pharmacology KW - Hematopoietic Stem Cells -- enzymology KW - Hematopoietic Stem Cells -- cytology KW - HIV Infections -- drug therapy KW - Apoptosis -- drug effects KW - HIV Protease Inhibitors -- pharmacology KW - HIV Infections -- enzymology KW - HIV Infections -- pathology KW - Hematopoietic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72315390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Protease+inhibitors+stimulate+hematopoiesis+and+decrease+apoptosis+and+ICE+expression+in+CD34%28%2B%29+cells.&rft.au=Sloand%2C+E+M%3BMaciejewski%2C+J%3BKumar%2C+P%3BKim%2C+S%3BChaudhuri%2C+A%3BYoung%2C+N&rft.aulast=Sloand&rft.aufirst=E&rft.date=2000-10-15&rft.volume=96&rft.issue=8&rft.spage=2735&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-09 N1 - Date created - 2000-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Calcium increases apolipoprotein B mRNA editing. AN - 72326770; 11027667 AB - ApoB-100 and apoB-48 are major components of chylomicrons, very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL). The two proteins are generated from a single apoB mRNA by apoB mRNA editing which induces an in-frame stop codon in apoB mRNA. Apolipoprotein B (apoB) mRNA editing is an important determinant of the proportion of full-length (apoB-100) and truncated (apoB-48) proteins in total apoB metabolism. Calcium is involved in the regulation of secretion and synthesis of VLDL and apoB. In this paper, we demonstrate for the first time that the amount of edited apoB mRNA in the cultured cells Caco-2 and McA7777 is markedly increased by calcium. Increasing extracellular calcium concentration, calcium ionophore (A23187 and ionomycin) treatment, and depleting calcium stores and raising cytoplasmic calcium concentration by thapsigargin increase apoB mRNA editing up to threefold in a dose dependent manner. Calcium has no direct stimulative effect on apoB mRNA editing in an in vitro editing system. The editing increase by extracellular calcium is not related to alterations of APOBEC-1 mRNA expression. These data suggest that calcium is not only involved in the regulation of apolipoprotein metabolism but also apoB mRNA editing. Copyright 2000 Academic Press. JF - Biochemical and biophysical research communications AU - Chen, Z AU - Eggerman, T L AU - Potosky, D AU - Arborati, M AU - Patterson, A P AD - National Heart, Lung and Blood Institute, Bethesda, Maryland, 20892, USA. Y1 - 2000/10/14/ PY - 2000 DA - 2000 Oct 14 SP - 221 EP - 227 VL - 277 IS - 1 SN - 0006-291X, 0006-291X KW - Apolipoproteins B KW - 0 KW - RNA, Messenger KW - Calcimycin KW - 37H9VM9WZL KW - Ionomycin KW - 56092-81-0 KW - Thapsigargin KW - 67526-95-8 KW - AICDA (activation-induced cytidine deaminase) KW - EC 3.5.4.- KW - APOBEC-1 Deaminase KW - EC 3.5.4.36 KW - APOBEC1 protein, human KW - Apobec1 protein, rat KW - Cytidine Deaminase KW - EC 3.5.4.5 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Cytidine Deaminase -- metabolism KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Caco-2 Cells KW - Ionomycin -- pharmacology KW - Calcimycin -- pharmacology KW - RNA, Messenger -- genetics KW - Thapsigargin -- pharmacology KW - Rats KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Drug Synergism KW - Time Factors KW - Calcium -- metabolism KW - Apolipoproteins B -- genetics KW - Calcium -- pharmacology KW - RNA Editing -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72326770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Calcium+increases+apolipoprotein+B+mRNA+editing.&rft.au=Chen%2C+Z%3BEggerman%2C+T+L%3BPotosky%2C+D%3BArborati%2C+M%3BPatterson%2C+A+P&rft.aulast=Chen&rft.aufirst=Z&rft.date=2000-10-14&rft.volume=277&rft.issue=1&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-07 N1 - Date created - 2000-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Time dependency of the action of nitric oxide in lipopolysaccharide-interferon-gamma-induced neuronal cell death in murine primary neuron-glia co-cultures. AN - 72336279; 11033002 AB - We investigated the time-dependency of the action of nitric oxide (NO) on glia-mediated neuronal cell death. Cortical neuron-glia co-cultures were treated with lipopolysaccharide and interferon gamma (LPS/IFNgamma). The production of NO was first detectable 9 h after the exposure to LPS/IFNgamma and increased for up to 48 h. A significant neuronal cell death was observed 36-48 h after treatment with LPS/IFNgamma. The NO generated at the initial stage of NO synthesis (about 12 h) following exposure to LPS/IFNgamma was found to be critical for LPS/IFNgamma-induced neurotoxicity. Furthermore, the rate of NO production at the initial stage of NO synthesis was correlated linearly with the extent of neuronal cell death. These findings suggest that the maximal rate of NO synthesis, instead of the accumulated NO(2)(-) level, is a sensitive index for predicting endotoxin-induced cytotoxicity. JF - Brain research AU - Jeohn, G H AU - Kim, W G AU - Hong, J S AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2000/10/13/ PY - 2000 DA - 2000 Oct 13 SP - 173 EP - 177 VL - 880 IS - 1-2 SN - 0006-8993, 0006-8993 KW - Lipopolysaccharides KW - 0 KW - Nitric Oxide KW - 31C4KY9ESH KW - Interferon-gamma KW - 82115-62-6 KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Coculture Techniques KW - Cell Death -- physiology KW - Animals KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Cells, Cultured KW - Kinetics KW - Mice KW - Cell Death -- drug effects KW - Neuroglia -- cytology KW - Cerebral Cortex -- cytology KW - Cerebral Cortex -- physiology KW - Neurons -- drug effects KW - Lipopolysaccharides -- pharmacology KW - Neurons -- cytology KW - Neurons -- physiology KW - Interferon-gamma -- pharmacology KW - Nitric Oxide -- physiology KW - Neuroglia -- drug effects KW - Neuroglia -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72336279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Time+dependency+of+the+action+of+nitric+oxide+in+lipopolysaccharide-interferon-gamma-induced+neuronal+cell+death+in+murine+primary+neuron-glia+co-cultures.&rft.au=Jeohn%2C+G+H%3BKim%2C+W+G%3BHong%2C+J+S&rft.aulast=Jeohn&rft.aufirst=G&rft.date=2000-10-13&rft.volume=880&rft.issue=1-2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-21 N1 - Date created - 2000-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A randomized, controlled trial of high-dose dextromethorphan in facial neuralgias. AN - 72379083; 11061252 AB - NMDA glutamate receptor antagonists such as ketamine and dextromethorphan reduce pain in certain neuropathic pain conditions. However, there have been no controlled trials of NMDA antagonists in facial neuralgias. A randomized, double-blind, crossover trial compared 6 weeks of oral dextromethorphan with active placebo (low-dose lorazepam) in 19 patients, stratified into three groups: 11 with facial pain and possible trigeminal neuropathy, five with anesthesia dolorosa, and three with idiopathic trigeminal neuralgia. Dosage was titrated in each patient to the highest level reached without disrupting normal activities. Patients completing the trial included 10 with possible trigeminal neuropathy, four with anesthesia dolorosa, and two with trigeminal neuralgia. In patients with possible trigeminal neuropathy and anesthesia dolorosa, dextromethorphan decreased pain by a mean of only 2 to 4%, and these estimates were not significant. Both patients with trigeminal neuralgia had more pain during dextromethorphan treatment than during placebo treatment. Of three patients who demonstrated an analgesic response to dextromethorphan during the main trial, only one repeatedly responded in four subsequent confirmatory drug-placebo crossovers. Dextromethorphan shows little or no analgesic efficacy in pain due to possible trigeminal neuropathy and anesthesia dolorosa. Additional trials are necessary to conclusively evaluate the efficacy of NMDA-receptor antagonists in trigeminal neuralgia. JF - Neurology AU - Gilron, I AU - Booher, S L AU - Rowan, M S AU - Smoller, M S AU - Max, M B AD - Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892-1258, USA. Y1 - 2000/10/10/ PY - 2000 DA - 2000 Oct 10 SP - 964 EP - 971 VL - 55 IS - 7 SN - 0028-3878, 0028-3878 KW - Dextromethorphan KW - 7355X3ROTS KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Dextromethorphan -- administration & dosage KW - Dextromethorphan -- adverse effects KW - Facial Neuralgia -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72379083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=A+randomized%2C+controlled+trial+of+high-dose+dextromethorphan+in+facial+neuralgias.&rft.au=Gilron%2C+I%3BBooher%2C+S+L%3BRowan%2C+M+S%3BSmoller%2C+M+S%3BMax%2C+M+B&rft.aulast=Gilron&rft.aufirst=I&rft.date=2000-10-10&rft.volume=55&rft.issue=7&rft.spage=964&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-21 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An alternative interpretation of nanobacteria-induced biomineralization AN - 17723750; 4783470 AB - The reported isolation of nanobacteria from human kidney stones raises the intriguing possibility that these microorganisms are etiological agents of pathological extraskeletal calcification [Kajander, E. O. & Ciftcioglu, N. (1998) Proc. Natl. Acad. Sci. USA 95, 8274-8279]. Nanobacteria were previously isolated from FBS after prolonged incubation in DMEM. These bacteria initiated biomineralization of the culture medium and were identified in calcified particles and biofilms by nucleic acid stains, 16S rDNA sequencing, electron microscopy, and the demonstration of a transferable biomineralization activity. We have now identified putative nanobacteria, not only from FBS, but also from human saliva and dental plaque after the incubation of 0.45- mu m membrane-filtered samples in DMEM. Although biomineralization in our "cultures" was transferable to fresh DMEM, molecular examination of decalcified biofilms failed to detect nucleic acid or protein that would be expected from growth of a living entity. In addition, biomineralization was not inhibited by sodium azide. Furthermore, the 16S rDNA sequences previously ascribed to Nanobacterium sanguineum and Nanobacterium sp. were found to be indistinguishable from those of an environmental microorganism, Phyllobacterium mysinacearum, that has been previously detected as a contaminant in PCR. Thus, these data do not provide plausible support for the existence of a previously undiscovered bacterial genus. Instead, we provide evidence that biomineralization previously attributed to nanobacteria may be initiated by nonliving macromolecules and transferred on "subculture" by self-propagating microcrystalline apatite. JF - Proceedings of the National Academy of Sciences, USA AU - Cisar, JO AU - Xu, D AU - Thompson, J AU - Swaim, W AU - Hu, L AU - Kopecko, D J AD - Oral Infection and Immunity Branch, and Cellular Imaging Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892, john.cisar@nih.gov Y1 - 2000/10/10/ PY - 2000 DA - 2000 Oct 10 SP - 11511 EP - 11515 VL - 97 IS - 21 SN - 0027-8424, 0027-8424 KW - nanobacteria KW - apatite KW - Calcium & Calcified Tissue Abstracts; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Phyllobacterium mysinacearum KW - Dental plaque KW - Mineralization KW - Nanobacterium KW - Calcification KW - Lithiasis KW - Saliva KW - Biofilms KW - rRNA 16S KW - T 20015:Calcification and ossification KW - J 02710:Identification, taxonomy and typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17723750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=An+alternative+interpretation+of+nanobacteria-induced+biomineralization&rft.au=Cisar%2C+JO%3BXu%2C+D%3BThompson%2C+J%3BSwaim%2C+W%3BHu%2C+L%3BKopecko%2C+D+J&rft.aulast=Cisar&rft.aufirst=JO&rft.date=2000-10-10&rft.volume=97&rft.issue=21&rft.spage=11511&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Nanobacterium; Phyllobacterium mysinacearum; Mineralization; Calcification; Biofilms; Saliva; Dental plaque; rRNA 16S; Bacteria; Lithiasis ER - TY - JOUR T1 - Intercellular delivery of a herpes simplex virus VP22 fusion protein from cells infected with lentiviral vectors AN - 17720343; 4783432 AB - Effective gene therapy depends on the efficient transfer of therapeutic genes and their protein products to target cells. Lentiviral vectors appear promising for virus-mediated gene delivery and long-term expression in nondividing cells. The herpes simplex virus type 1 tegument protein VP22 has recently been shown to mediate intercellular transport of proteins, raising the possibility that it may be helpful in a setting where the global delivery of therapeutic proteins is desired. To investigate the effectiveness of lentiviral vectors to deliver genes encoding proteins fused to VP22, and to test whether the system is sufficiently potent to allow protein delivery from transduced cells in vitro and in vivo, fusion constructs of VP22 and the enhanced green fluorescent protein (EGFP) were prepared and delivered into target cells by using HIV-1-based lentiviral vectors. To follow the spread of VP22-EGFP to other cells, transduced COS-7 cells were coplated with a number of different cell types, including brain choroid plexus cells, human endothelial cells, H9 cells, and HeLa cells. We found that VP22-EGFP fusion proteins were transported from transduced cells to recipient cells and that such fusion proteins accumulated in the nucleus and in the cytoplasm of such cells. To determine the ability to deliver fusion proteins in vivo, we injected transduced H9 cells as well as the viral vector directly into the brain of mice. We present evidence that VP22-EGFP fusion proteins were transported effectively from lentivirus transduced cells in vivo. We also show that the VP22-EGFP fusion protein encoded by the lentivirus is transported between cells. Our data indicate that such fusion proteins are present in the nucleus and in the cytoplasm of neighboring cells. Therefore, lentiviral vectors may provide a potent biological system for delivering genes encoding therapeutic proteins fused to VP22. JF - Proceedings of the National Academy of Sciences, USA AU - Lai, Z AU - Han, I AU - Zirzow, G AU - Brady, RO AU - Reiser, J AD - Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, bradyr@ninds.nih.gov Y1 - 2000/10/10/ PY - 2000 DA - 2000 Oct 10 SP - 11297 EP - 11302 VL - 97 IS - 21 SN - 0027-8424, 0027-8424 KW - HSV KW - Herpes simplex virus KW - VP22 protein KW - lentivirus KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Expression vectors KW - Tegument KW - Gene therapy KW - Lentivirus KW - Fusion protein KW - W3 33181:Gene therapy vectors KW - V 22050:Viral genetics including virus reactivation KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17720343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Intercellular+delivery+of+a+herpes+simplex+virus+VP22+fusion+protein+from+cells+infected+with+lentiviral+vectors&rft.au=Lai%2C+Z%3BHan%2C+I%3BZirzow%2C+G%3BBrady%2C+RO%3BReiser%2C+J&rft.aulast=Lai&rft.aufirst=Z&rft.date=2000-10-10&rft.volume=97&rft.issue=21&rft.spage=11297&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lentivirus; Herpes simplex virus; Gene therapy; Expression vectors; Tegument; Fusion protein ER - TY - JOUR T1 - Vulnerability to addiction: new research opportunities. AN - 72366447; 11054764 JF - American journal of medical genetics AU - Leshner, A I AD - National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA. leshner@nih.gov Y1 - 2000/10/09/ PY - 2000 DA - 2000 Oct 09 SP - 590 EP - 591 VL - 96 IS - 5 SN - 0148-7299, 0148-7299 KW - Index Medicus KW - Animals KW - Humans KW - Research KW - Behavior, Addictive -- genetics KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72366447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+genetics&rft.atitle=Vulnerability+to+addiction%3A+new+research+opportunities.&rft.au=Leshner%2C+A+I&rft.aulast=Leshner&rft.aufirst=A&rft.date=2000-10-09&rft.volume=96&rft.issue=5&rft.spage=590&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+genetics&rft.issn=01487299&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-13 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long forms of the dopamine receptor (DRD4) gene VNTR are more prevalent in substance abusers: no interaction with functional alleles of the catechol-o-methyltransferase (COMT) gene. AN - 72365827; 11054777 AB - Substance abuse is a complex behavior that is caused by both environmental and genetic factors. Work to understand the genetic factors has focused on genes related to dopamine activity because of its critical role in rewarding and reinforcing behaviors. The DRD3 and other dopamine receptor subtypes are expressed in many areas of the limbic system, and have been the objects of study for their possible roles in several neuropsychiatric disorders. Interest in variants of the D4 gene was heightened by reports that some alleles were more frequent in individuals who score high on Novelty Seeking, an aspect of personality that may be related to drug seeking behavior. We now show that the long form of the DRD4 gene is more frequent in individuals with high quantity/frequency of drug use compared to controls (chi(2) = 5.7, df = 1, P = 0.017, odds ratio = 1.89, CI = 1.1-3.2). There is no difference in DRD3 allele frequencies in these samples, and there is no interaction of DRD4 alleles with those of the catecholamine-o-methyl- transferase gene (COMT) that we previously identified to be more frequent in substance abusers than controls [Vandenbergh, et al.: 1997: Am. J. Med. Gen. 74:439-442]. JF - American journal of medical genetics AU - Vandenbergh, D J AU - Rodriguez, L A AU - Hivert, E AU - Schiller, J H AU - Villareal, G AU - Pugh, E W AU - Lachman, H AU - Uhl, G R AD - Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA.'' Y1 - 2000/10/09/ PY - 2000 DA - 2000 Oct 09 SP - 678 EP - 683 VL - 96 IS - 5 SN - 0148-7299, 0148-7299 KW - DRD4 protein, human KW - 0 KW - Protein Isoforms KW - Receptors, Dopamine D2 KW - Receptors, Dopamine D4 KW - 137750-34-6 KW - DNA KW - 9007-49-2 KW - Catechol O-Methyltransferase KW - EC 2.1.1.6 KW - Index Medicus KW - Genotype KW - Catechol O-Methyltransferase -- genetics KW - Alleles KW - Gene Frequency KW - Logistic Models KW - Humans KW - DNA -- genetics KW - Protein Isoforms -- genetics KW - Receptors, Dopamine D2 -- genetics KW - Tandem Repeat Sequences -- genetics KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72365827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+genetics&rft.atitle=Long+forms+of+the+dopamine+receptor+%28DRD4%29+gene+VNTR+are+more+prevalent+in+substance+abusers%3A+no+interaction+with+functional+alleles+of+the+catechol-o-methyltransferase+%28COMT%29+gene.&rft.au=Vandenbergh%2C+D+J%3BRodriguez%2C+L+A%3BHivert%2C+E%3BSchiller%2C+J+H%3BVillareal%2C+G%3BPugh%2C+E+W%3BLachman%2C+H%3BUhl%2C+G+R&rft.aulast=Vandenbergh&rft.aufirst=D&rft.date=2000-10-09&rft.volume=96&rft.issue=5&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+genetics&rft.issn=01487299&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-13 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The upstream region of the Rpe65 gene confers retinal pigment epithelium-specific expression in vivo and in vitro and contains critical octamer and E-box binding sites. AN - 72299560; 10896939 AB - RPE65 is essential for all-trans- to 11-cis-retinoid isomerization, the hallmark reaction of the retinal pigment epithelium (RPE). Here, we identify regulatory elements in the Rpe65 gene and demonstrate their functional relevance to Rpe65 gene expression. We show that the 5' flanking region of the mouse Rpe65 gene, like the human gene, lacks a canonical TATA box and consensus GC and CAAT boxes. The mouse and human genes do share several cis-acting elements, including an octamer, a nuclear factor one (NFI) site, and two E-box sites, suggesting a conserved mode of regulation. A mouse Rpe65 promoter/beta-galactosidase transgene containing bases -655 to +52 (TR4) of the mouse 5' flanking region was sufficient to direct high RPE-specific expression in transgenic mice, whereas shorter fragments (-297 to +52 or -188 to +52) generated only background activity. Furthermore, transient transfection of analogous TR4/luciferase constructs also directed high reporter activity in the human RPE cell line D407 but weak activity in the non-RPE cell lines HeLa, HepG2, and HS27. Functional binding of potential transcription factors to the octamer sequence, AP-4, and NFI sites was demonstrated by directed mutagenesis, electrophoretic mobility shift assay, and cross-linking. Mutations of these sites abolished binding and corresponding transcriptional activity and indicated that octamer and E-box transcription factors synergistically regulate the RPE65 promoter function. Thus, we have identified the regulatory region in the Rpe65 gene that accounts for tissue-specific expression in the RPE and found that octamer and E-box transcription factors play a critical role in the transcriptional regulation of the Rpe65 gene. JF - The Journal of biological chemistry AU - Boulanger, A AU - Liu, S AU - Henningsgaard, A A AU - Yu, S AU - Redmond, T M AD - Laboratory of Retinal Cell and Molecular Biology, NEI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2000/10/06/ PY - 2000 DA - 2000 Oct 06 SP - 31274 EP - 31282 VL - 275 IS - 40 SN - 0021-9258, 0021-9258 KW - 5' Untranslated Regions KW - 0 KW - CCAAT-Enhancer-Binding Proteins KW - Carrier Proteins KW - Cross-Linking Reagents KW - DNA-Binding Proteins KW - Eye Proteins KW - NFI Transcription Factors KW - Nuclear Proteins KW - Proteins KW - Transcription Factors KW - Y-Box-Binding Protein 1 KW - YBX1 protein, human KW - enhancer-binding protein AP-4 KW - Luciferases KW - EC 1.13.12.- KW - retinoid isomerohydrolase KW - EC 3.1.1.64 KW - beta-Galactosidase KW - EC 3.2.1.23 KW - cis-trans-Isomerases KW - EC 5.2.- KW - Index Medicus KW - Animals KW - Transcription Factors -- metabolism KW - Cell Nucleus -- metabolism KW - Humans KW - Cross-Linking Reagents -- metabolism KW - Transcription, Genetic KW - Mice, Transgenic KW - Mutagenesis, Site-Directed KW - Promoter Regions, Genetic KW - CCAAT-Enhancer-Binding Proteins -- metabolism KW - Genes, Reporter KW - Molecular Sequence Data KW - Gene Expression Regulation KW - Sequence Homology, Amino Acid KW - Luciferases -- genetics KW - Male KW - DNA-Binding Proteins -- metabolism KW - HeLa Cells KW - Transgenes KW - Amino Acid Sequence KW - Mice KW - Protein Binding KW - Binding Sites KW - Cattle KW - Base Sequence KW - Transfection KW - beta-Galactosidase -- genetics KW - Cell Line KW - Female KW - Pigment Epithelium of Eye -- metabolism KW - Proteins -- genetics KW - Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72299560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+upstream+region+of+the+Rpe65+gene+confers+retinal+pigment+epithelium-specific+expression+in+vivo+and+in+vitro+and+contains+critical+octamer+and+E-box+binding+sites.&rft.au=Boulanger%2C+A%3BLiu%2C+S%3BHenningsgaard%2C+A+A%3BYu%2C+S%3BRedmond%2C+T+M&rft.aulast=Boulanger&rft.aufirst=A&rft.date=2000-10-06&rft.volume=275&rft.issue=40&rft.spage=31274&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-13 N1 - Date created - 2000-10-23 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AF271297; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased c-Jun expression in neurons affected by lysolecithin-induced demyelination in rats. AN - 72281236; 10998551 AB - The objective of this study was to investigate whether the expression of c-Jun is involved in the neuronal response to experimental demyelination. Lysolecithin-induced demyelination was generated in two distinct neural systems in rats: in the pontocerebellar and the septohippocampal pathways. Six days after the stereotaxic injections of lysolecithin, expression of the immediate early gene c-Jun was visualized by immunohistochemistry. Lesion-specific expression of the Jun protein was observed in neurons whose axons transverse the demyelinated area. Unlike the neural response to axotomy, lysolecithin treatment did not alter the expression of the neuropeptide galanin in the septohippocampal pathway. These results suggest that c-Jun protein expression might represent one step in the neuronal response to demyelination and that this response might be distinct in its downstream events from axotomy. JF - Neuroscience letters AU - Lovas, G AU - Palkovits, M AU - Komoly, S AD - Laboratory of Developmental Neurogenetics, NINDS, NIH, Building 36, Room 5D-09, 36 Convent Drive, MSC 4160, Bethesda, MD 20892-4160, USA. lovasg@ninds.nih.gov Y1 - 2000/10/06/ PY - 2000 DA - 2000 Oct 06 SP - 71 EP - 74 VL - 292 IS - 2 SN - 0304-3940, 0304-3940 KW - Lysophosphatidylcholines KW - 0 KW - Proto-Oncogene Proteins c-jun KW - Galanin KW - 88813-36-9 KW - Index Medicus KW - Rats KW - Septum of Brain -- metabolism KW - Animals KW - Rats, Sprague-Dawley KW - Galanin -- metabolism KW - Brain Chemistry -- drug effects KW - Lysophosphatidylcholines -- pharmacology KW - Hippocampus -- metabolism KW - Septum of Brain -- pathology KW - Hippocampus -- pathology KW - Female KW - Brain Chemistry -- physiology KW - Neurons -- metabolism KW - Demyelinating Diseases -- metabolism KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Demyelinating Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72281236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Increased+c-Jun+expression+in+neurons+affected+by+lysolecithin-induced+demyelination+in+rats.&rft.au=Lovas%2C+G%3BPalkovits%2C+M%3BKomoly%2C+S&rft.aulast=Lovas&rft.aufirst=G&rft.date=2000-10-06&rft.volume=292&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-07 N1 - Date created - 2000-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health outcomes after prostatectomy or radiotherapy for prostate cancer: results from the Prostate Cancer Outcomes Study. AN - 72311199; 11018094 AB - Radical prostatectomy and external beam radiotherapy are the two major therapeutic options for treating clinically localized prostate cancer. Because survival is often favorable regardless of therapy, treatment decisions may depend on other therapy-specific health outcomes. In this study, we compared the effects of two treatments on urinary, bowel, and sexual functions and on general health-related quality-of-life outcomes over a 2-year period following initial treatment. A diverse cohort of patients aged 55-74 years who were newly diagnosed with clinically localized prostate cancer and received either radical prostatectomy (n = 1156) or external beam radiotherapy (n = 435) were included in this study. A propensity score was used to balance the two treatment groups because they differed in some baseline characteristics. This score was used in multivariable cross-sectional and longitudinal regression analyses comparing the treatment groups. All statistical tests were two-sided. Almost 2 years after treatment, men receiving radical prostatectomy were more likely than men receiving radiotherapy to be incontinent (9.6% versus 3.5%; P:<.001) and to have higher rates of impotence (79.6% versus 61.5%; P:<.001), although large, statistically significant declines in sexual function were observed in both treatment groups. In contrast, men receiving radiotherapy reported greater declines in bowel function than did men receiving radical prostatectomy. All of these differences remained after adjustments for propensity score. The treatment groups were similar in terms of general health-related quality of life. There are important differences in urinary, bowel, and sexual functions over 2 years after different treatments for clinically localized prostate cancer. In contrast to previous reports, these outcome differences reflect treatment delivered to a heterogeneous group of patients in diverse health care settings. These results provide comprehensive and representative information about long-term treatment complications to help guide and inform patients and clinicians about prostate cancer treatment decisions. JF - Journal of the National Cancer Institute AU - Potosky, A L AU - Legler, J AU - Albertsen, P C AU - Stanford, J L AU - Gilliland, F D AU - Hamilton, A S AU - Eley, J W AU - Stephenson, R A AU - Harlan, L C AD - Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892-7344, USA. potosky@nih.gov Y1 - 2000/10/04/ PY - 2000 DA - 2000 Oct 04 SP - 1582 EP - 1592 VL - 92 IS - 19 SN - 0027-8874, 0027-8874 KW - Index Medicus KW - United States KW - Humans KW - SEER Program KW - Aged KW - Mental Health KW - Radiotherapy -- adverse effects KW - Registries KW - Pain -- etiology KW - Risk Factors KW - Treatment Outcome KW - Role KW - Middle Aged KW - Bias (Epidemiology) KW - Time Factors KW - Male KW - Urinary Incontinence -- etiology KW - Prostatectomy -- adverse effects KW - Prostatic Neoplasms -- surgery KW - Prostatic Neoplasms -- psychology KW - Quality of Life KW - Fecal Incontinence -- etiology KW - Erectile Dysfunction -- etiology KW - Prostatic Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72311199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Health+outcomes+after+prostatectomy+or+radiotherapy+for+prostate+cancer%3A+results+from+the+Prostate+Cancer+Outcomes+Study.&rft.au=Potosky%2C+A+L%3BLegler%2C+J%3BAlbertsen%2C+P+C%3BStanford%2C+J+L%3BGilliland%2C+F+D%3BHamilton%2C+A+S%3BEley%2C+J+W%3BStephenson%2C+R+A%3BHarlan%2C+L+C&rft.aulast=Potosky&rft.aufirst=A&rft.date=2000-10-04&rft.volume=92&rft.issue=19&rft.spage=1582&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-14 N1 - Date created - 2000-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Natl Cancer Inst. 2001 Mar 7;93(5):401-2 [11238710] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines. AN - 72310409; 11018093 AB - HER2 is a membrane receptor whose overexpression is strongly associated with poor prognosis in breast carcinomas. Inhibition of HER2 activity can reduce tumor growth, which led to the development of Herceptin, an anti-HER2 monoclonal antibody (MAb) that is already in clinical use. However, the objective response rate to Herceptin monotherapy is quite low. HER2 activity can also be inhibited by the highly cytotoxic antibiotic geldanamycin (GA). However, GA is not used clinically because of its adverse toxicity. Our purpose was to enhance the inhibitory activity of anti-HER2 MAb by coupling it to GA. We synthesized 17-(3-aminopropylamino)GA (17-APA-GA) and conjugated it to the anti-HER2 MAb e21, to form e21 : GA. The noninternalizing anti-HER2 MAb AE1 was used as a control. Internalization assays and western blot analyses were used to determine whether the anti-HER2 MAbs and their immunoconjugates were internalized into HER2-expressing cells and reduced HER2 levels. All statistical tests were two-sided. The immunoconjugate e21 : GA inhibited the proliferation of HER2-overexpressing cell lines better than unconjugated e21 (concentration required for 50% inhibition = 40 versus 1650 microg/mL, respectively). At 15 microg/mL, e21 : GA reduced HER2 levels by 86% within 16 hours, whereas unconjugated e21, 17-APA-GA, or AE1 : GA reduced HER2 levels by only 20%. These effects were not caused by release of 17-APA-GA from the immunoconjugate because immunoconjugates containing [(3)H]GA were stable in serum at 37 degrees C. Furthermore, e21 : GA did not significantly inhibit proliferation of the adult T-cell leukemia cell line HuT102, which is HER2 negative yet highly sensitive to GA. Our findings suggest that conjugating GA to internalizing MAbs enhances the inhibitory effect of the MAbs. This approach might also be applied in cellular targeting via growth factors and may be of clinical interest. JF - Journal of the National Cancer Institute AU - Mandler, R AU - Wu, C AU - Sausville, E A AU - Roettinger, A J AU - Newman, D J AU - Ho, D K AU - King, C R AU - Yang, D AU - Lippman, M E AU - Landolfi, N F AU - Dadachova, E AU - Brechbiel, M W AU - Waldmann, T A AD - Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. rayam@box-r.nih.gov Y1 - 2000/10/04/ PY - 2000 DA - 2000 Oct 04 SP - 1573 EP - 1581 VL - 92 IS - 19 SN - 0027-8874, 0027-8874 KW - Antibiotics, Antineoplastic KW - 0 KW - Antibodies, Monoclonal KW - Benzoquinones KW - Immunoconjugates KW - Lactams, Macrocyclic KW - Quinones KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Animals KW - Blotting, Western KW - Tumor Cells, Cultured KW - Humans KW - Mice KW - Up-Regulation KW - Mice, Inbred BALB C KW - Female KW - Breast Neoplasms -- immunology KW - Breast Neoplasms -- drug therapy KW - Receptor, ErbB-2 -- metabolism KW - Antibiotics, Antineoplastic -- pharmacology KW - Receptor, ErbB-2 -- immunology KW - Quinones -- immunology KW - Antibiotics, Antineoplastic -- immunology KW - Quinones -- pharmacology KW - Antibodies, Monoclonal -- pharmacology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72310409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Immunoconjugates+of+geldanamycin+and+anti-HER2+monoclonal+antibodies%3A+antiproliferative+activity+on+human+breast+carcinoma+cell+lines.&rft.au=Mandler%2C+R%3BWu%2C+C%3BSausville%2C+E+A%3BRoettinger%2C+A+J%3BNewman%2C+D+J%3BHo%2C+D+K%3BKing%2C+C+R%3BYang%2C+D%3BLippman%2C+M+E%3BLandolfi%2C+N+F%3BDadachova%2C+E%3BBrechbiel%2C+M+W%3BWaldmann%2C+T+A&rft.aulast=Mandler&rft.aufirst=R&rft.date=2000-10-04&rft.volume=92&rft.issue=19&rft.spage=1573&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-14 N1 - Date created - 2000-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Natl Cancer Inst. 2000 Oct 4;92(19):1549-51 [11018081] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo expression and genomic organization of the mouse cyclin I gene (Ccni). AN - 72368626; 11054536 AB - Cyclins control cell-cycle progression by regulating the activity of cyclin-dependent kinases. Cyclin I was recently added to the cyclin family of proteins because of the presence of a cyclin box motif in the deduced amino-acid sequence. Cyclin I may share functional roles with cyclin G1 and G2 because of the high structural similarity between their deduced amino-acid sequences. However, the biological and functional roles of this subclass of cyclins remain obscure. The mouse cyclin G1 and G2 genes have previously been cloned and characterized. In this report, we describe the cloning of the mouse homolog of cyclin I. The cyclin I cDNA sequence was used to determine the genomic organization of the mouse cyclin I gene which co-localizes with cyclin G2 to chromosome 5E3.3-F1.3. Cyclin I was transcribed from seven exons distributed over more than 19kb of genomic sequence. The expression of cyclin I was determined in various tissues, but no clear correlation with the proliferative state was found. Furthermore, in contrast to cyclin G1, cyclin I expression was stable during cell-cycle progression after partial hepatectomy in both the absence and presence of DNA damage. Transient expression of cyclin I-green fluorescent protein (GFP) fusion proteins in cell lines showed that cyclin I was distributed throughout the cell in contrast with the mainly cytoplasmic localization of cyclin G2 and nuclear localization of cyclin G1. Our results indicate that despite the close structural similarity between cyclin G1, G2 and I, these three proteins are likely to have distinct biological roles. JF - Gene AU - Jensen, M R AU - Audolfsson, T AU - Factor, V M AU - Thorgeirsson, S S AD - Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2000/10/03/ PY - 2000 DA - 2000 Oct 03 SP - 59 EP - 67 VL - 256 IS - 1-2 SN - 0378-1119, 0378-1119 KW - Ccni protein, mouse KW - 0 KW - Cyclin I KW - Cyclins KW - DNA, Complementary KW - RNA, Messenger KW - DNA KW - 9007-49-2 KW - Index Medicus KW - 3T3 Cells KW - Animals KW - Blotting, Northern KW - DNA, Complementary -- genetics KW - Exons KW - Gene Expression KW - Mice KW - Amino Acid Sequence KW - Tissue Distribution KW - Sequence Analysis, DNA KW - RNA, Messenger -- genetics KW - Mice, Inbred BALB C KW - Cloning, Molecular KW - Base Sequence KW - RNA, Messenger -- metabolism KW - Blotting, Southern KW - DNA -- genetics KW - Molecular Sequence Data KW - Introns KW - DNA, Complementary -- chemistry KW - DNA -- chemistry KW - Male KW - Genes -- genetics KW - Cyclins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72368626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=In+vivo+expression+and+genomic+organization+of+the+mouse+cyclin+I+gene+%28Ccni%29.&rft.au=Jensen%2C+M+R%3BAudolfsson%2C+T%3BFactor%2C+V+M%3BThorgeirsson%2C+S+S&rft.aulast=Jensen&rft.aufirst=M&rft.date=2000-10-03&rft.volume=256&rft.issue=1-2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-01-11 N1 - Date created - 2000-12-06 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AF228740; GENBANK; AF228739; AF005886 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. AN - 72390349; 11013228 AB - Human DNA polymerase iota (pol(iota)) is a recently discovered enzyme that exhibits extremely low fidelity on undamaged DNA templates. Here, we show that poliota is able to facilitate limited translesion replication of a thymine-thymine cyclobutane pyrimidine dimer (CPD). More importantly, however, the bypass event is highly erroneous. Gel kinetic assays reveal that pol(iota) misinserts T or G opposite the 3' T of the CPD approximately 1.5 times more frequently than the correct base, A. While pol(iota) is unable to extend the T.T mispair significantly, the G.T mispair is extended and the lesion completely bypassed, with the same efficiency as that of the correctly paired A. T base pair. By comparison, pol(iota) readily misinserts two bases opposite a 6-4 thymine-thymine pyrimidine-pyrimidone photoproduct (6-4PP), but complete lesion bypass is only a fraction of that observed with the CPD. Our data indicate, therefore, that poliota possesses the ability to insert nucleotides opposite UV photoproducts as well as to perform unassisted translesion replication that is likely to be highly mutagenic. JF - The EMBO journal AU - Tissier, A AU - Frank, E G AU - McDonald, J P AU - Iwai, S AU - Hanaoka, F AU - Woodgate, R AD - Section on DNA Replication, Repair and Mutagenesis, National Institute of Child Health and Human Development, Bethesda, MD 20892-2725, USA. Y1 - 2000/10/02/ PY - 2000 DA - 2000 Oct 02 SP - 5259 EP - 5266 VL - 19 IS - 19 SN - 0261-4189, 0261-4189 KW - Pyrimidine Dimers KW - 0 KW - pyrimidine-pyrimidone dimer KW - DNA polymerase iota KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Index Medicus KW - Base Pairing KW - Humans KW - Pyrimidine Dimers -- chemistry KW - DNA Damage KW - Base Pair Mismatch KW - DNA Replication KW - DNA-Directed DNA Polymerase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72390349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=Misinsertion+and+bypass+of+thymine-thymine+dimers+by+human+DNA+polymerase+iota.&rft.au=Tissier%2C+A%3BFrank%2C+E+G%3BMcDonald%2C+J+P%3BIwai%2C+S%3BHanaoka%2C+F%3BWoodgate%2C+R&rft.aulast=Tissier&rft.aufirst=A&rft.date=2000-10-02&rft.volume=19&rft.issue=19&rft.spage=5259&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-12-08 N1 - Date created - 2000-12-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3094-9 [10725365] Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11922-7 [10518552] Biochemistry. 2000 Apr 25;39(16):4575-80 [10769112] EMBO J. 2000 Jun 15;19(12):3100-9 [10856253] Genes Dev. 2000 Jul 1;14(13):1642-50 [10887158] Cold Spring Harb Symp Quant Biol. 2000;65:61-9 [12760021] J Biol Chem. 1987 Oct 25;262(30):14689-96 [3667598] Mol Cell Biol. 1993 Jul;13(7):4276-83 [8321229] Methods Enzymol. 1995;262:232-56 [8594351] Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2941-6 [8610147] Science. 1996 Jun 14;272(5268):1646-9 [8658138] Nature. 1996 Aug 22;382(6593):729-31 [8751446] J Biol Chem. 1997 May 23;272(21):13945-54 [9153257] Biochemistry. 1998 Jun 2;37(22):8218-26 [9609718] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6876-80 [9618506] Carcinogenesis. 1998 May;19(5):945-9 [9635887] Mol Cell Biol. 1999 Jan;19(1):147-54 [9858539] Nucleic Acids Res. 1999 Nov 15;27(22):4468-75 [10536157] Genes Cells. 1999 Nov;4(11):607-18 [10620008] J Biol Chem. 2000 Feb 11;275(6):4391-7 [10660610] Trends Biochem Sci. 2000 Mar;25(3):143-7 [10694886] J Biol Chem. 2000 Mar 17;275(11):7447-50 [10713043] J Biol Chem. 2000 Mar 17;275(11):8233-9 [10713149] Cytogenet Cell Genet. 1998;83(1-2):18-20 [9925914] Science. 1999 Feb 12;283(5404):1001-4 [9974380] Mol Cell Biol. 1999 Mar;19(3):2206-11 [10022907] Mutat Res. 1999 Mar 10;433(2):89-98 [10102035] EMBO J. 1999 Jun 15;18(12):3491-501 [10369688] Nature. 1999 Jun 17;399(6737):700-4 [10385124] Science. 1999 Jul 9;285(5425):263-5 [10398605] Genomics. 1999 Aug 15;60(1):20-30 [10458907] Genes Dev. 1999 Sep 1;13(17):2191-5 [10485842] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4186-91 [10760286] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Subunit-specific degradation of the UmuD/D' heterodimer by the ClpXP protease: the role of trans recognition in UmuD' stability AN - 17693114; 4774798 AB - The Escherichia coli UmuD' protein is a subunit of the recently described error-prone DNA polymerase, pol V. UmuD' is initially synthesized as an unstable and mutagenically inactive pro-protein, UmuD. Upon processing, UmuD' assumes a relatively stable conformation and becomes mutagenically active. While UmuD and UmuD' by themselves exist in vivo as homodimers, when together they preferentially interact to form heterodimers. Quite strikingly, it is in this context that UmuD' becomes susceptible to ClpXP-mediated proteolysis. Here we report a novel targeting mechanism designed for degrading the mutagenically active UmuD' subunit of the UmuD/D' heterodimer complex, while leaving the UmuD protein intact. Surprisingly, a signal that is essential and sufficient for targeting UmuD' for degradation was found to reside on UmuD not UmuD'. UmuD was also shown to be capable of channeling an excess of UmuD' to ClpXP for degradation, thereby providing a mechanism whereby cells can limit error-prone DNA replication. JF - EMBO Journal AU - Gonzalez, M AU - Rasulova, F AU - Maurizi, M R AU - Woodgate, R AD - Section on DNA Replication, Repair and Mutagenesis, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2725, woodgate@helix.nih.gov Y1 - 2000/10/02/ PY - 2000 DA - 2000 Oct 02 SP - 5251 EP - 5258 VL - 19 IS - 19 SN - 0261-4189, 0261-4189 KW - ClpXP protease KW - ClpXP protein KW - UmuD protein KW - UmuD' protein KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - DNA biosynthesis KW - Escherichia coli KW - Proteinase KW - J 02727:Amino acids, peptides and proteins KW - N 14940:Nucleic acid-binding proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17693114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Subunit-specific+degradation+of+the+UmuD%2FD%27+heterodimer+by+the+ClpXP+protease%3A+the+role+of+trans+recognition+in+UmuD%27+stability&rft.au=Gonzalez%2C+M%3BRasulova%2C+F%3BMaurizi%2C+M+R%3BWoodgate%2C+R&rft.aulast=Gonzalez&rft.aufirst=M&rft.date=2000-10-02&rft.volume=19&rft.issue=19&rft.spage=5251&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Escherichia coli; DNA biosynthesis; Proteinase ER - TY - JOUR T1 - Hemodynamic dysfunction and cytochrome P4501A mRNA expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin during embryonic stages of lake trout development. AN - 72286123; 11000095 AB - Lake trout embryos exposed to [(3)H]2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) manifest toxicity after hatching by subcutaneous edema of the yolk sac, pericardial edema, meningeal edema, subcutaneous hemorrhages, and a marked congestion of blood flow in various vascular beds culminating in death. Our objective was to determine if this syndrome was associated temporally with morphologic lesions in the vascular endothelium, increased vascular permeability, and cytochrome P4501A (CYP1A) mRNA induction. Lake trout embryos exposed as fertilized eggs to TCDD were found to exhibit marked reductions in perfusion of the peripheral vasculature during the early sac fry stage of development (stage F(1)9), which consistently preceded other gross lesions and mortality observed later in sac fry development (stage F(2)10). This reduction in blood flow was manifested as severe capillary congestion and hemoconcentration in certain vascular beds. Transmission electron microscopic (TEM) examination of endothelial cells in these vascular beds failed to reveal cellular necrosis at hatching (stage E(5)8) and throughout sac fry development (stages F(1)9-F(2)10). Rather, only subtle ultrastructural changes in endothelial cells were found consisting of increased vacuolation, separation of intercellular junctions, and cytoplasmic blebbing, consistent with the TCDD dose and time course for developmental cardiovascular toxicity, which began to manifest itself in some embryos approximately 1 week prior to hatching (E(5)8). To assess permeability of yolk sac vasculature to certain constituents in blood, sac fry (stage F(2)10) were analyzed for the presence of plasma proteins, granulocytes, and serum creatine kinase activity in yolk sac subcutaneous edema fluid from control and TCDD-exposed treatment groups. TCDD dose- and time-related increases in yolk sac edema volume, plasma protein content of edema fluid, granulocyte concentration, and creatine kinase activity in the fluid were observed in midstage and late stage of sac fry development (stage F(2)10). Thus, yolk sac subcutaneous edema fluid is an ultrafiltrate of blood and results from increased vascular permeability. In contrast to the changes in vascular blood flow and permeability induced by TCDD during stages F(1)9 and F(2)10 of sac fry development, respectively, CYP1A mRNA levels were induced by TCDD as early as the 10-somite embryo (stage E(2)5). TCDD also caused a dose-related increase in CYP1A mRNA levels in sac fry at hatching (stage E(5)8) and throughout sac fry development (stages F(1)9-F(2)10). We conclude that subtle, ultrastructural changes in vascular endothelial cells consistently precede increases in vascular permeability and sac fry mortality; however, induction of CYP1A mRNA occurs prior to any observable morphological lesions, changes in vascular permeability, or sac fry mortality. Copyright 2000 Academic Press. JF - Toxicology and applied pharmacology AU - Guiney, P D AU - Walker, M K AU - Spitsbergen, J M AU - Peterson, R E AD - NIEHS Aquatic Biomedical Center, University of Wisconsin-Milwaukee, 600 E. Greenfield Avenue, Milwaukee, Wisconsin 53204, USA. Y1 - 2000/10/01/ PY - 2000 DA - 2000 Oct 01 SP - 1 EP - 14 VL - 168 IS - 1 SN - 0041-008X, 0041-008X KW - Polychlorinated Dibenzodioxins KW - 0 KW - RNA, Messenger KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Capillaries -- pathology KW - Capillaries -- drug effects KW - Yolk Sac -- drug effects KW - Hemodynamics -- drug effects KW - Polychlorinated Dibenzodioxins -- pharmacokinetics KW - Trout -- embryology KW - Cytochrome P-450 Enzyme System -- genetics KW - RNA, Messenger -- analysis KW - Polychlorinated Dibenzodioxins -- toxicity KW - Embryo, Nonmammalian -- metabolism KW - Embryo, Nonmammalian -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72286123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Hemodynamic+dysfunction+and+cytochrome+P4501A+mRNA+expression+induced+by+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+during+embryonic+stages+of+lake+trout+development.&rft.au=Guiney%2C+P+D%3BWalker%2C+M+K%3BSpitsbergen%2C+J+M%3BPeterson%2C+R+E&rft.aulast=Guiney&rft.aufirst=P&rft.date=2000-10-01&rft.volume=168&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-10-26 N1 - Date created - 2000-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chlormethiazole: effectiveness against toxic effects of cocaine in mice. AN - 72274374; 10991973 AB - Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experimental and clinical studies reporting effectiveness against the toxic effects of heroin and methamphetamine, chlormethiazole was systematically tested in the present study for its effectiveness against cocaine-induced seizures and lethality in mice. The protective effects of chlormethiazole were evaluated against single, submaximal convulsive (75 mg/kg) or lethal (110 mg/kg) doses of cocaine. Chlormethiazole also was tested against the expression (anticonvulsant effect) and development (antiepileptogenic effect) of cocaine-kindled seizures, and against fully developed kindled seizures. Cocaine-kindled seizures were produced by a total of five daily treatments with 60 mg/kg cocaine. The inverted-screen test was used to assess behavioral side effects of chlormethiazole. Chlormethiazole protected against acute cocaine-induced convulsions (ED(50) = 7.0 mg/kg) and lethality (ED(50)= 21.8 mg/kg) with a robust separation [protective index (PI) = TD(50)/ED(50) = 22.3 and 7.2, respectively] from doses producing behavioral side effects (TD(50) = 156 mg/kg). Chlormethiazole suppressed the behavioral expression of cocaine-kindled seizures and prevented the development of sensitization to the convulsant effects of cocaine. It was also effective in suppressing fully developed kindled seizures. Relative to cocaine seizures in naive mice, chlormethiazole was equieffective, less potent (ED(50) = 22.3 mg/kg), and had a reduced protective index (PI = 3.7) against cocaine-induced seizures in kindled mice. The protective profile and protective index of chlormethiazole were superior to those of the benzodiazepines clonazepam and diazepam, which were of limited efficacy and had low protective indices (PI = approximately 1). The results of this study predict the potential utility of chlormethiazole for the treatment of life-threatening complications of cocaine abuse for which no specific treatment has yet been identified. JF - The Journal of pharmacology and experimental therapeutics AU - Gasior, M AU - Ungard, J T AU - Witkin, J M AD - Drug Development Group, Behavioral Neuroscience Branch, Addiction Research Center, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA. mgasior@mclean.harvard.edu Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 153 EP - 161 VL - 295 IS - 1 SN - 0022-3565, 0022-3565 KW - Anticonvulsants KW - 0 KW - GABA Modulators KW - Receptors, GABA-A KW - Chlormethiazole KW - 0C5DBZ19HV KW - Clonazepam KW - 5PE9FDE8GB KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Kindling, Neurologic -- drug effects KW - Dose-Response Relationship, Drug KW - Cocaine-Related Disorders -- drug therapy KW - Receptors, GABA-A -- drug effects KW - Motor Activity -- drug effects KW - Mice KW - Male KW - Clonazepam -- pharmacology KW - Anticonvulsants -- pharmacology KW - GABA Modulators -- pharmacology KW - Chlormethiazole -- pharmacology KW - Cocaine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72274374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Chlormethiazole%3A+effectiveness+against+toxic+effects+of+cocaine+in+mice.&rft.au=Gasior%2C+M%3BUngard%2C+J+T%3BWitkin%2C+J+M&rft.aulast=Gasior&rft.aufirst=M&rft.date=2000-10-01&rft.volume=295&rft.issue=1&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-03 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide. AN - 72274343; 10991969 AB - A massive degeneration of dopamine-containing neurons in the substantia nigra (SN) in the midbrain is characteristic of Parkinson's disease. Inflammation in the brain has long been speculated to play a role in the pathogenesis of this neurological disorder. Recently, we reported that treatment of primary rat mesencephalic mixed neuron-glia cultures with lipopolysaccharide (LPS) led to the activation of microglia, resident immune cells of the brain, and subsequent death of dopaminergic neurons. The LPS-induced degeneration of dopaminergic neurons was significantly attenuated by the opiate receptor antagonist (-)-naloxone and its inactive isomer (+)-naloxone, with equal potency, through an inhibition of microglial activation and their production of neurotoxic factors. In this study, injection of LPS into the rat SN led to the activation of microglia and degeneration of dopaminergic neurons: microglial activation was observed as early as 6 h and loss of dopaminergic neurons was detected 3 days after the LPS injection. Furthermore, the LPS-induced loss of dopaminergic neurons in the SN was time- and LPS concentration-dependent. Systemic infusion of either (-)-naloxone or (+)-naloxone inhibited the LPS-induced activation of microglia and significantly reduced the LPS-induced loss of dopaminergic neurons in the SN. These in vivo results combined with our cell culture observations confirmed that naloxone protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation and suggest that naloxone would have therapeutic efficacy in the treatment of inflammation-related neurological disorders. In addition, the inflammation-mediated degeneration of dopaminergic neurons in the rat SN resulting from the targeted injection of LPS may serve as a useful model to gain further insights into the pathogenesis of Parkinson's disease. JF - The Journal of pharmacology and experimental therapeutics AU - Liu, B AU - Jiang, J W AU - Wilson, B C AU - Du, L AU - Yang, S N AU - Wang, J Y AU - Wu, G C AU - Cao, X D AU - Hong, J S AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. liu3@niehs.nih.gov Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 125 EP - 132 VL - 295 IS - 1 SN - 0022-3565, 0022-3565 KW - Lipopolysaccharides KW - 0 KW - Narcotic Antagonists KW - Naloxone KW - 36B82AMQ7N KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Microglia -- drug effects KW - Male KW - Naloxone -- pharmacology KW - Substantia Nigra -- pathology KW - Substantia Nigra -- drug effects KW - Lipopolysaccharides -- toxicity KW - Narcotic Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72274343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Systemic+infusion+of+naloxone+reduces+degeneration+of+rat+substantia+nigral+dopaminergic+neurons+induced+by+intranigral+injection+of+lipopolysaccharide.&rft.au=Liu%2C+B%3BJiang%2C+J+W%3BWilson%2C+B+C%3BDu%2C+L%3BYang%2C+S+N%3BWang%2C+J+Y%3BWu%2C+G+C%3BCao%2C+X+D%3BHong%2C+J+S&rft.aulast=Liu&rft.aufirst=B&rft.date=2000-10-01&rft.volume=295&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-03 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - 1999 NIEHS symposium reports on oxidative stress, apoptosis, and abnormal development: introduction. AN - 72270728; 10992265 JF - Teratology AU - Heindel, J Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 233 VL - 62 IS - 4 KW - Index Medicus KW - United States KW - Humans KW - National Institutes of Health (U.S.) KW - Abnormalities, Drug-Induced KW - Apoptosis KW - Oxidative Stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72270728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Teratology&rft.atitle=1999+NIEHS+symposium+reports+on+oxidative+stress%2C+apoptosis%2C+and+abnormal+development%3A+introduction.&rft.au=Heindel%2C+J&rft.aulast=Heindel&rft.aufirst=J&rft.date=2000-10-01&rft.volume=62&rft.issue=4&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Teratology&rft.issn=00403709&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-09 N1 - Date created - 2000-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR. AN - 72253071; 10979918 AB - Because concurrent infections with geohelminth parasites might impair the immune response to oral vaccines, we studied the vibriocidal antibody response to the oral cholera vaccine CVD 103-HgR in children infected with Ascaris lumbricoides and investigated the effect of albendazole pretreatment on the postvaccination response. Children with ascariasis were randomized to receive either 2 sequential doses of 400 mg of albendazole or placebo. After the second dose, CVD 103-HgR was given, and serum vibriocidal antibody levels were measured before and 10 days after vaccination. Postvaccination rates of seroconversion were greater in the treatment group that received albendazole (P=.06). Significantly greater rates of seroconversion and geometric mean titer were observed in the albendazole group in subjects with non-O ABO blood groups. A significant association was observed between vibriocidal seroconversion rates and treatment group, suggesting that A. lumbricoides infections impair the immune response to oral cholera vaccine, particularly in subjects of non-O blood groups. JF - The Journal of infectious diseases AU - Cooper, P J AU - Chico, M E AU - Losonsky, G AU - Sandoval, C AU - Espinel, I AU - Sridhara, R AU - Aguilar, M AU - Guevara, A AU - Guderian, R H AU - Levine, M M AU - Griffin, G E AU - Nutman, T B AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. pc102d@hotmail.com Y1 - 2000/10// PY - 2000 DA - October 2000 SP - 1199 EP - 1206 VL - 182 IS - 4 SN - 0022-1899, 0022-1899 KW - Anthelmintics KW - 0 KW - Antibodies, Bacterial KW - Bacterial Vaccines KW - Blood Group Antigens KW - Cholera Vaccines KW - Vaccines, Attenuated KW - cholera vaccine CVD 103-HgR KW - Albendazole KW - F4216019LN KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Trichuris -- drug effects KW - Drug Interactions KW - Blood Group Antigens -- immunology KW - Ecuador KW - Humans KW - Antibody Formation KW - Child KW - Adolescent KW - Male KW - Female KW - Bacterial Vaccines -- immunology KW - Cholera Vaccines -- immunology KW - Ascariasis -- drug therapy KW - Ascariasis -- immunology KW - Vaccines, Attenuated -- immunology KW - Antibodies, Bacterial -- blood KW - Ascaris lumbricoides -- drug effects KW - Anthelmintics -- therapeutic use KW - Albendazole -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72253071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Albendazole+treatment+of+children+with+ascariasis+enhances+the+vibriocidal+antibody+response+to+the+live+attenuated+oral+cholera+vaccine+CVD+103-HgR.&rft.au=Cooper%2C+P+J%3BChico%2C+M+E%3BLosonsky%2C+G%3BSandoval%2C+C%3BEspinel%2C+I%3BSridhara%2C+R%3BAguilar%2C+M%3BGuevara%2C+A%3BGuderian%2C+R+H%3BLevine%2C+M+M%3BGriffin%2C+G+E%3BNutman%2C+T+B&rft.aulast=Cooper&rft.aufirst=P&rft.date=2000-10-01&rft.volume=182&rft.issue=4&rft.spage=1199&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2000-11-03 N1 - Date created - 2000-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER -