FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Beiler, JSB Zhu, KM Hunter, S Payne-Wilks, K Roland, CL Chinchilli, VM AF Beiler, JSB Zhu, KM Hunter, S Payne-Wilks, K Roland, CL Chinchilli, VM TI A case-control study of menstrual factors in relation to breast cancer risk in African-American women SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION LA English DT Article DE African-American women; breast cancer; case-control study; menstrual factors ID BLACK-WOMEN; POSTMENARCHEAL PERIOD; REPRODUCTIVE FACTORS; RACIAL-DIFFERENCES; ETHNIC-DIFFERENCES; CYCLE PATTERNS; CLINICAL-TRIAL; MENOPAUSE; EXPERIENCE; PREVENTION AB Menstrual characteristics may serve as surrogate measures of endogenous estrogen and may be related to breast cancer risk. No previous studies have systematically investigated menstrual factors in relation to the disease in African-American women. This case-control study is aimed to assess the relationship between menstrual factors and breast cancer in African-American women. Cases were 304 African-American women, aged 20-64 living in three Tennessee counties, diagnosed with breast cancer between 1995 and 1998, Controls were selected through random-digit dialing and frequency matched to cases (n=305). Phone interviews were conducted on menstrual factors-age at menarche, time to regularity, cycle length, flow length, age at menopause-and other risk factors. Logistic regression showed that compared to women with short cycle length (<28 days), women with average cycle length greater than or equal to28 had decreased risk of breast cancer (odds ratio (OR)=0.60, 95% confidence interval (CI), 0.38-0.94). Dose-response analyses showed decreasing risk with longer cycle length. Results by menopausal status revealed an inverse relationship was shown only in postmenopausal women. No significant associations were observed for other menstrual factors. Findings suggest that cycle length has an inverse association with breast cancer in African-American women that may primarily exist for post-menopausal tumors. C1 Walter Reed Army Med Ctr, United States Mil Canc Inst, Washington, DC 20307 USA. Penn State Univ, Coll Med, Dept Hlth Evaluat Sci, Hershey, PA USA. Meharry Med Coll, Sch Med, Dept Occupat & Prevent Med, Nashville, TN 37208 USA. RP Zhu, KM (reprint author), Walter Reed Army Med Ctr, United States Mil Canc Inst, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM kangmin.zhu@na.amedd.army.mil NR 49 TC 6 Z9 6 U1 0 U2 1 PU NATL MED ASSOC PI WASHINGON PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA SN 0027-9684 J9 J NATL MED ASSOC JI J. Natl. Med. Assoc. PD OCT PY 2003 VL 95 IS 10 BP 930 EP 938 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 836IJ UT WOS:000222548800001 PM 14620704 ER PT J AU Ivins, BJ Schwab, KA Warden, D Harvey, S Hoilien, MAJM Powell, J Johnson, EW Salazar, AM AF Ivins, BJ Schwab, KA Warden, D Harvey, S Hoilien, MAJM Powell, J Johnson, EW Salazar, AM TI Traumatic brain injury in US army paratroopers: Prevalence and character SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE head injury; brain injury; parachuting; US Army ID MILD HEAD-INJURY; UNITED-STATES; EPIDEMIOLOGY; CONCUSSION; POPULATION; FEATURES AB Background: This study presents self-reported traumatic brain injury (TBI) prevalence rates for 2,337 active duty U.S. Army soldiers who underwent baseline testing as part of a larger study of military TBI. Methods: A computerized self-report questionnaire was administered to a convenience sample of 2,337 highly functioning active-duty soldiers at Fort Bragg, North Carolina, who underwent baseline testing during a 13-month period in 1999 and 2000 as part of a larger ongoing Institutional Review Board-approved study examining the consequences of brain injuries among paratroopers. Results: Approximately 23% of all of the soldiers surveyed reported sustaining a TBI after joining the Army. More than twice as many paratroopers reported sustaining TBI after joining the Army than did nonparatroopers (p < 0.001). Parachute-related TBI accounted for this difference. Nearly all of these injuries were mild. Less than 2% of paratroopers and no nonparatroopers reported loss of consciousness lasting more than 20 minutes. It was also shown that paratroopers with a history of TBI before joining the Army had a higher prevalence of TBI while serving in the Army (35%) than paratroopers without prior TBI (27.2%) (p = 0.002). Conclusion: This study demonstrates that parachuting appears to be a risk factor for mild TBI in the U.S. Army and that paratroopers with a history of TBI before joining the Army might be at somewhat increased risk of sustaining additional TBI while serving in the Army. C1 Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20012 USA. Def & Vet Head Injury Program, Ft Brag, NC USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Joint Special Operat Med Training Ctr, Ft Bragg, NC USA. USA, Aeromed Res Lab, Ft Rucker, AL USA. Landsthul Reg Med Ctr, Psychol Serv, Landsthul, Germany. RP Ivins, BJ (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, POB 59181, Washington, DC 20012 USA. NR 25 TC 32 Z9 32 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2003 VL 55 IS 4 BP 617 EP 621 DI 10.1097/01.TA.0000052368.9457..D4 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 733GN UT WOS:000185991700005 PM 14566111 ER PT J AU Knight, DA Manifold, CA Blue, J King, JA AF Knight, DA Manifold, CA Blue, J King, JA TI A randomized, controlled trial comparing arteriovenous to venovenous rewarming of severe hypothermia in a porcine model SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Annual Meeting of the Wilderness-Medical-Society CY AUG 07-11, 2001 CL WHISTLER, CANADA SP Wildrness Med Soc DE hypothermia; resuscitation; continuous arteriovenous rewarming (CAVR); continuous venovenous rewarming (CVVR); extracorporeal rewarming; hypothermia ID HEMORRHAGIC-SHOCK; TRAUMA PATIENTS AB Background: The purpose of this study was to evaluate active rewarming using continuous arteriovenous rewarming (CAVR) and continuous venovenous rewarming (CVVR) methods during severe hypothermia using an electromagnetic fluid warmer. Rapid rewarming using these techniques is superior to passive rewarming and is possible with commercially available equipment. Methods: Eighteen swine (55-65 kg) were assigned to CAVR, CVVR, or control. Vascular access was obtained via central lines (8.5-French) in all subjects. Subjects were cooled to 27degreesC (80.6degreesF) in an ice bath, and then dried, covered, and connected to the rewarming device. The carotid artery (CAVR) or internal jugular vein (CVVR) was used for circuit inflow. Warmed 39degreesC (102.2degreesF) blood was returned via the femoral vein. Hemodynamic parameters and temperatures (pulmonary artery and rectal) were recorded until reaching an endpoint of a pulmonary artery temperature of 37degreesC (98.6degreesF). Results: Mean rewarming time in the CAVR group was 2 hours 14 minutes, with a mean rewarming rate of 4.5degreesC/h (8.1degreesF/h, 0.034degreesC/kg/h). Total circulating volume averaged 65 L. CVVR averaged 3 hours 8 minutes, with a mean rewarming rate of 3.2degreesC/h (5.8degreesF/h, 0.024degreesC/kg/h). Total circulating volume averaged 67 L. Controls averaged 10 hours 42 minutes, with a mean rate of 0.9degreesC/h (1.7degreesF/h, 0.007degreesC/kg/h). The CAVR group was faster than the CVVR group in both the rewarming rate and total time to rewarming (p = 0.034 and p = 0.040, respectively). Both experimental groups were significantly different from controls in rewarming rate and total time to rewarming (p < 0.001). Conclusions: CAVR offers the most rapid rate of rewarming. CVVR offers a rapid rate using less invasive procedures. Both techniques are markedly superior to passive rewarming methods typically used during early resuscitation. C1 Wilford Hall USAF Med Ctr, Dept Emergency Med, San Antonio Uniformed Serv Hlth Educ Consortium E, San Antonio, TX 78236 USA. Brooke Army Med Ctr, San Antonio, TX USA. RP Knight, DA (reprint author), Wilford Hall USAF Med Ctr, Dept Emergency Med, San Antonio Uniformed Serv Hlth Educ Consortium E, 2200 Berquist Dr,Suite 1, San Antonio, TX 78236 USA. NR 25 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2003 VL 55 IS 4 BP 741 EP 746 DI 10.1097/01.TA.0000085647.01817.E3 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 733GN UT WOS:000185991700030 PM 14566132 ER PT J AU Skoch, GJ AF Skoch, GJ TI Experimental investigation of centrifugal compressor stabilization techniques SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT International Gas Turbine and Aeroengine Congress and Exhibition CY JUN 16-19, 2003 CL ATLANTA, GEORGIA ID SURGE AB Results from a series of experiments to investigate techniques for extending the stable flow range of a centrifugal compressor are reported: The research was conducted in a highspeed centrifugal compressor at the NASA Glenn Research Center. The stabilizing effect of steadily flowing air-streams injected into the vaneless region of a vane-island diffuser through the shroud surface is described. Parametric variations of injection angle, injection flow rate, number of injectors, injector spacing, and injection versus bleed were investigated for a range of impeller speeds and tip clearances. Both the compressor discharge and an external source were used for the injection air supply. The stabilizing effect of flow obstructions created by tubes that were inserted into the diffuser vaneless space through the shroud was also investigated. Tube immersion into the vaneless space was varied in the flow obstruction experiments. Results from testing done at impeller design speed and tip clearance are presented. Surge margin improved by 1.7 points using injection air that was supplied from within the compressor. Externally supplied injection air was used to return the compressor to stable operation after being throttled into surge. The tubes, which were capped to prevent mass flux, provided 6.5 points of additional surge margin over the baseline surge margin of 11.7 points. C1 USA, Res Lab, NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. RP Skoch, GJ (reprint author), USA, Res Lab, NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. NR 11 TC 21 Z9 24 U1 1 U2 5 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0889-504X J9 J TURBOMACH JI J. Turbomach.-Trans. ASME PD OCT PY 2003 VL 125 IS 4 BP 704 EP 713 DI 10.1115/1.1624846 PG 10 WC Engineering, Mechanical SC Engineering GA 756AM UT WOS:000187443700011 ER PT J AU O'Donnell, SD Gillespie, DL Starnes, BW Parker, MV Johnson, CA Rasmussen, TE Goff, JM Rich, NM AF O'Donnell, SD Gillespie, DL Starnes, BW Parker, MV Johnson, CA Rasmussen, TE Goff, JM Rich, NM TI Endovascular assisted in situ bypass grafting: A simplified technique for saphenous vein side branch occlusion SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 31st Annual Meeting of the Society-for-Clinical-Vascular-Surgery CY MAR 04-09, 2003 CL MIAMI, FLORIDA SP Soc Clin Vasc Surg ID RESIDUAL ARTERIOVENOUS-FISTULAS; COMPLICATIONS; MULTICENTER; PATENCY; INSITU; COST AB The in situ bypass procedure for lower extremity limb salvage requires a long continuous incision or multiple interrupted incisions over the greater saphenous vein to ligate the saphenous vein side branches. This can result in wound complications that frequently prolong hospital stay and threaten the graft. In an effort to reduce the incidence of wound complications, alternate methods of occluding the vein side branches have been used. One method is to deliver coils under angioscopic vision into the saphenous vein side branches. This report details a simplified technique that uses widely available catheter-based equipment to perform saphenous vein side branch occlusion under fluoroscopic guidance. C1 Walter Reed Army Med Ctr, Dept Vasc Surg, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP O'Donnell, SD (reprint author), Walter Reed Army Med Ctr, Dept Vasc Surg, Peripheral Vasc Surg Ward 64,6900 Georgia Ave NW, Washington, DC 20307 USA. OI Gillespie, David/0000-0002-4378-9465 NR 10 TC 1 Z9 1 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD OCT PY 2003 VL 38 IS 4 BP 856 EP 858 DI 10.1016/S0741-5214(03)00731-6 PG 3 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 730YX UT WOS:000185858700041 PM 14560245 ER PT J AU Bender, LC Li, H Thompson, BC Morrow, PC Valdez, R AF Bender, LC Li, H Thompson, BC Morrow, PC Valdez, R TI Infectious disease survey of gemsbok in New Mexico SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE bluetongue; bovine respiratory syncytial virus; desert bighorn sheep; gemsbok; malignant catarrhal fever; mule deer; New Mexico; parainfluenza-3; pasteurellosis ID LINKED-IMMUNOSORBENT-ASSAY; MALIGNANT CATARRHAL FEVER; WHITE-TAILED DEER; COMPLEMENT-FIXATION; BIGHORN SHEEP; VIRUS; BLUETONGUE; DIAGNOSIS; RUMINANTS AB Exotic wildlife can introduce new diseases or act as reservoirs of endemic diseases. On White Sands Missile Range, New Mexico (USA), significant declines in populations of native ungulates generally correspond to increases in range and population density of the exotic gemsbok (Oryx gazella gazella), introduced beginning in 1969. We surveyed gemsbok in 2001 for exposure to a variety of diseases potentially important for native ungulates. High seroprevalence was found for malignant catarrhal fever virus (49 [98%] of 50 sera; 43 [96%] of 45 plasma samples), bluetongue virus (48 [96%] of 50), bovine respiratory syncytial virus (33 [66%] of 50), and parainfluenza-3 virus (10 [20%] of 50). Low numbers of Nematodirus spp. eggs in a few individuals were the only parasites detected in gemsbok. Exposure to the above diseases in gemsbok is of interest to managers because of potential implications for recovery of desert bighorn sheep (Ovis canadensis mexicana) and desert mule deer (Odocoileus hemionus crooki) in the White Sands area because each has been implicated in mortality in these species either in the White Sands area or elsewhere in the western/southwestern United States. C1 US Geol Survey, New Mexico Cooperat Fish & Wildlife Res Unit, Las Cruces, NM 88003 USA. Washington State Univ, Anim Dis Res Unit, USDA ARS, Pullman, WA 99164 USA. USA, Environm Stewardship Div, CSTE DTC ES, White Sands Missile Range, NM 88002 USA. New Mexico State Univ, Dept Fisheries & Wildlife Sci, Las Cruces, NM 88003 USA. RP Bender, LC (reprint author), US Geol Survey, New Mexico Cooperat Fish & Wildlife Res Unit, POB 30003 MSC 4901, Las Cruces, NM 88003 USA. NR 39 TC 9 Z9 10 U1 1 U2 4 PU WILDLIFE DISEASE ASSN, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD OCT PY 2003 VL 39 IS 4 BP 772 EP 778 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA 760BX UT WOS:000187791800003 PM 14733271 ER PT J AU Lopez, J Copps, J Wilhelmsen, C Moore, R Kubay, J St-Jacques, M Halayko, S Kranendonk, C Toback, S DeShazer, D Fritz, DL Tom, M Woods, DE AF Lopez, J Copps, J Wilhelmsen, C Moore, R Kubay, J St-Jacques, M Halayko, S Kranendonk, C Toback, S DeShazer, D Fritz, DL Tom, M Woods, DE TI Characterization of experimental equine glanders SO MICROBES AND INFECTION LA English DT Article DE glanders; equine; infection ID BURKHOLDERIA-MALLEI; SUBTRACTIVE HYBRIDIZATION; VIRULENCE DETERMINANT; IDENTIFICATION; POLYSACCHARIDE; PSEUDOMALLEI; MELIOIDOSIS; MODEL AB Considerable advances in understanding of the disease caused by Burkholderia mallei have been made employing a combination of tools including genetic techniques and animal infection models. The development of small animal models has allowed us to assess the role of a number of putative virulence determinants in the pathogenesis of disease due to B. mallei. Due to the difficulties in performing active immunization studies in small animals, and due to the fact that the horse is the target mammalian species for glanders, we have initiated experimental studies on glanders in horses. Intratracheal deposition of B. mallei produced clinical glanders with organisms being recovered from tissues of infected horses. The model should prove to be of considerable value in our ongoing studies on the pathogenesis and vaccine development for glanders. (C) 2003 Published by Editions scientifiques et medicales Elsevier SAS. C1 Univ Calgary, Fac Med, Hlth Sci Ctr, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada. Natl Ctr Foreign Anim Dis, Winnipeg, MB R3E 3M4, Canada. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Woods, DE (reprint author), Univ Calgary, Fac Med, Hlth Sci Ctr, Dept Microbiol & Infect Dis, 3330 Hosp Dr,NW, Calgary, AB T2N 4N1, Canada. NR 25 TC 31 Z9 34 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1286-4579 J9 MICROBES INFECT JI Microbes Infect. PD OCT PY 2003 VL 5 IS 12 BP 1125 EP 1131 DI 10.1016/j.micinf.2003.07.004 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 738UL UT WOS:000186306200009 PM 14554254 ER PT J AU Korenyi-Both, AL AF Korenyi-Both, AL TI Untitled SO MILITARY MEDICINE LA English DT Letter C1 USA, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2003 VL 168 IS 10 BP VI EP VI PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 740LL UT WOS:000186403800001 ER PT J AU Sheehan, KM Murphy, MM Reynolds, K Creedon, JF White, J Kazel, M AF Sheehan, KM Murphy, MM Reynolds, K Creedon, JF White, J Kazel, M TI The response of a bone resorption marker to marine recruit training SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Annual Meeting of the American-College-of-Sports-Medicine CY MAY 00-JUN 01, 2001 CL BALTIMORE, MARYLAND SP Amer Coll Sports Med ID EXERCISE-RELATED INJURIES; STRESS-FRACTURE; CLINICAL-APPLICATION; BIOCHEMICAL MARKERS; MINERAL DENSITY; RISK-FACTORS; TURNOVER; WOMEN; IMPACT; METABOLISM AB Objectives: This study measured the response of deoxypyridinoline, a biomarker of bone resorption, during 11 weeks of Marine recruit training. Methods: Urine samples were obtained from 155 female and 58 male Marine recruits from the first morning void every 3 days during training. Training miles of weight-bearing exercise were recorded daily, and injury data were obtained from the medical clinic staff. Results: Deoxypyridinoline was significantly (p < 0.001) increased at week 2 and weeks 9 through 11 for women and at weeks 10 and 11 for men. The increase in bone resorption corresponded to an increase in miles of weight-bearing exercise performed throughout training. The incidence of stress fracture and reaction was 3.9% and 14.8%, respectively, for women and 1.7% and 3.4%, respectively, for men. Conclusions: Significant bone resorption took place at the end of Marine recruit training due to accumulation of weight-bearing exercise throughout training and the increase in marching toward the end. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. Beaufort Naval Hosp, Beaufort, SC USA. RP Sheehan, KM (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 42 Kansas St, Natick, MA 01760 USA. NR 27 TC 6 Z9 6 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2003 VL 168 IS 10 BP 797 EP 801 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 740LL UT WOS:000186403800009 PM 14620642 ER PT J AU Francis, PO Fowler, EB Willard, CC AF Francis, PO Fowler, EB Willard, CC TI Migrating third molar: A report of a case SO MILITARY MEDICINE LA English DT Article ID PATHOLOGICAL MIGRATION; TEETH AB Pathologic migration is an abnormal change in the position of a tooth within the dental arch. There are many etiologic factors associated with this phenomenon, but the exact cause is often difficult to diagnose. The following is a report of a 42-year-old man exhibiting a unique form of bilateral migration of his mandibular third molars. He was asymptomatic and unaware of this occurrence. The morbidity to remove these teeth was deemed too great to justify extraction. Biopsy of the overlying tissue associated with a left-impacted third molar revealed no significant pathologic process other than inflammation and some hyperplasia within the dental follicle. Histologic-radiographic correlation was inconclusive in determining whether epithelium from pericoronal soft tissue involving the right third molar was from a hyperplastic dental follicle or a small dentigerous cyst. It is speculated that the ultimate cause of the migration of the third molars was severe, aggressive periodontal disease of the adjacent molars. C1 USA, DENTAC, Dent Clin 3, Dept Periodont, Ft Lewis, WA 98439 USA. USA, DENTAC, Okubo Dent Clin, Dept Periodont, Ft Lewis, WA 98439 USA. Madigan Army Med Ctr, Dent CLin, Dept Oral & Maxillofacial Pathol, Ft Lewis, WA 98439 USA. RP Francis, PO (reprint author), USA, DENTAC, Dent Clin 3, Dept Periodont, Ft Lewis, WA 98439 USA. NR 26 TC 3 Z9 3 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2003 VL 168 IS 10 BP 802 EP 806 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 740LL UT WOS:000186403800010 PM 14620643 ER PT J AU Bell, MR Ritchie, EC AF Bell, MR Ritchie, EC TI Breastfeeding in the military: Part I. Information and resources provided to service women SO MILITARY MEDICINE LA English DT Article ID MATERNAL EMPLOYMENT; PROLONGED LACTATION; INFANT ILLNESS; RISK; DURATION; INITIATION; CANCER; USA AB Increasing the incidence and duration of breastfeeding is a major goal in Healthy People 2010. Little is known about the progress that the Department of Defense (DoD) health care system, TRICARE, has made toward reaching that goal. This study is the first of a two-part series that reviews DoD/TRI-CARE support for breastfeeding and discusses policy issues related to breastfeeding. Methods used include searches of MEDLINE, DoD/TRICARE documents, legislative and policy websites, and the Internet. A survey of DoD hospitals was also conducted. Based on the search results and survey, TRICARE may not be meeting the goals of Healthy People 2010. There is minimal policy guidance regarding breastfeeding. Programs are in place at most hospitals, but the quality and content varies greatly. After mothers return to work, support is meager. DOD/TRICARE may need to establish written policy guidelines and devote additional resources to adequately support breastfeeding. C1 Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. Off Assistant Sec Def Hlth Affairs, Mental Hlth Policy & Womens Issues, Falls Church, VA 22041 USA. RP Bell, MR (reprint author), USA, CHPPM, Aberdeen Proving Ground, MD 21010 USA. NR 59 TC 6 Z9 6 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2003 VL 168 IS 10 BP 807 EP 812 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 740LL UT WOS:000186403800011 PM 14620644 ER PT J AU Hughes, PA Magnet, AD Fishbain, JT AF Hughes, PA Magnet, AD Fishbain, JT TI Eosinophilic meningitis: A case series report and review of the literature SO MILITARY MEDICINE LA English DT Review ID VISCERAL LARVA MIGRANS; ANGIOSTRONGYLUS-CANTONENSIS; CEREBROSPINAL-FLUID; GNATHOSTOMA-SPINIGERUM; HODGKINS-DISEASE; THAILAND; PLEOCYTOSIS AB Prompted by a case of eosinophilic meningitis (EM), a review of the literature was performed to evaluate the strength of the diagnoses associated with EM and compares these results with our hospital's experience. Articles were critically reviewed for supporting evidence, method of diagnosis, and established standards for specific diagnosis. EM has been defined as greater than or equal to10 eosinophils per mm(3) or greater than or equal to10% eosinophils of total cell count. Sixty-two cases of EM were found at our institution and reviewed. The results of this case series review concur with those found in the literature. It also suggests the importance of considering infectious and noninfectious etiologies when faced with eosinophils in the cerebrospinal fluid. This review and case study analysis provides the clinician with a critically established set of differential diagnoses and a concise definition of EM that may assist the physician in the evaluation of patients presenting with eosinophils in the cerebrospinal fluid. C1 Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. RP Hughes, PA (reprint author), Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. NR 38 TC 8 Z9 9 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2003 VL 168 IS 10 BP 817 EP 821 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 740LL UT WOS:000186403800013 PM 14620646 ER PT J AU Harper, DA AF Harper, DA TI 'Perhaps-more-than-enough': The dangers of mate-idolatry in Milton's 'Samson Agonistes' SO MILTON QUARTERLY LA English DT Article C1 US Mil Acad, W Point, NY 10996 USA. RP Harper, DA (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 19 TC 0 Z9 0 U1 0 U2 1 PU BLACKWELL PUBLISHERS PI MALDEN PA 350 MAIN STREET, STE 6, MALDEN, MA 02148 USA SN 0026-4326 J9 MILTON QUART JI Milton Q. PD OCT PY 2003 VL 37 IS 3 BP 139 EP 151 DI 10.1111/j.1094-348X.2003.00055.x PG 13 WC Poetry SC Literature GA 736HF UT WOS:000186164800002 ER PT J AU Horton, SB Easton, T Parker, RG AF Horton, SB Easton, T Parker, RG TI The linear arrangement problem on recursively constructed graphs SO NETWORKS LA English DT Article DE optimal linear arrangement; complexity; Halin graphs ID SUBGRAPHS; TREES AB The linear arrangement problem on graphs is a relatively old and quite well-known problem. Hard in general, it remains open on general recursive graphs (i.e., partial k-trees, etc.), which is somewhat frustrating since most hard graph problems are easily solved on recursive graphs. In this paper, we examine the linear arrangement problem with respect to these structures. Included are some negative (complexity) results as well as a solvable case. (C) 2003 Wiley Periodicals, Inc. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. Kansas State Univ, Dept Ind & Mfg Syst Engn, Manhattan, KS 66506 USA. RP US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. OI Easton, Todd/0000-0001-9278-0259 NR 14 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0028-3045 EI 1097-0037 J9 NETWORKS JI Networks PD OCT PY 2003 VL 42 IS 3 BP 165 EP 168 DI 10.1002/net.10093 PG 4 WC Computer Science, Hardware & Architecture; Operations Research & Management Science SC Computer Science; Operations Research & Management Science GA 724CU UT WOS:000185470100005 ER PT J AU Frey, WC Pilcher, J AF Frey, WC Pilcher, J TI Obstructive sleep-related breathing disorders in patients evaluated for bariatric surgery SO OBESITY SURGERY LA English DT Article; Proceedings Paper CT 96th International Conference of the American-Thoracic-Society CY MAY 03-10, 2000 CL TORONTO, CANADA SP Amer Thorac Soc ID MORBIDLY OBESE-PATIENTS; GASTRIC BYPASS; DAYTIME SLEEPINESS; APNEA; PREVALENCE; ADULTS; ANESTHESIA; SAFETY AB Background: Obesity is a well known risk factor for obstructive sleep apnea (OSA). Medical therapy is not effective for morbid obesity. Bariatric surgery is therefore a reasonable option for weight reduction for patients with clinically severe obesity. Unrecognized OSA, especially in those patients receiving abdominal surgery, has influenced perioperative morbidity and morality. The incidence of OSA for patients being evaluated for bariatric surgery has not been previously defined. Methods: 40 consecutive patients being evaluated for bariatric surgery were examined with a history, physical examination and laboratory data. Polysomnography (PSG) was conducted in all patients regardless of symptoms. Results: An obstructive sleep-related breathing disorder (OSRBD) was present in 88% of the patients. OSA was present in 29 of 41 (71%) and upper airway resistance syndrome (UARS) in 7 of 41 (17%). The mean low oxygen desaturation was 84% and continuous positive airway pressure (CPAP) was 10 cm H 20 pressure. The majority of the patients were women and mean BMI was 47 kg/m(2). Patient characteristics failed to predict the severity of OSRBD. Conclusions: This population of clinically severe obese patients being evaluated for bariatric surgery had an 88% incidence of an OSRBD, 71% with OSA. Appropriate therapy with CPAP perioperatively would theoretically prevent hypoxic complications associated with OSRBD. Providers should have a low threshold for ordering a PSG as part of the preoperative evaluation for bariatric surgery. Empiric CPAP at 10 cm H2O should be considered for those patients who cannot complete a PSG before surgery. C1 Brooke Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Ft Sam Houston, TX 78234 USA. RP Frey, WC (reprint author), Brooke Army Med Ctr, Dept Pulm Crit Care & Sleep Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 31 TC 147 Z9 151 U1 0 U2 3 PU F D-COMMUNICATIONS INC PI TORONTO PA 3100 BAYVIEW AVE, UNIT 4, TORONTO, ONTARIO M2N 5L3, CANADA SN 0960-8923 J9 OBES SURG JI Obes. Surg. PD OCT PY 2003 VL 13 IS 5 BP 676 EP 683 DI 10.1381/096089203322509228 PG 8 WC Surgery SC Surgery GA 737VW UT WOS:000186253300004 PM 14627460 ER PT J AU O'Connor, JD Driggers, RG Vollmerhausen, RH Devitt, N Olson, J AF O'Connor, JD Driggers, RG Vollmerhausen, RH Devitt, N Olson, J TI Fifty-percent probability of identification (N-50) comparison for targets in the visible and infrared spectral bands SO OPTICAL ENGINEERING LA English DT Article DE visible spectra; infrared spectra; comparison; targets; probability of identification AB We describe a comparison of target identification performance between targets in the IR and visible bands. Increasing levels of Gaussian blur are applied to 12 varying viewpoint aspects of 12 targets in both the IR and visible spectra. Results are analyzed as a function of blur level and target size to give identification probability as a function of resolvable cycles on target. Probability curves for the IR and visible results are compared and the 50% probabilities of identification (N-50) are estimated for both cases. The results show that there is a significant difference in the target acquisition characteristics in the visible and IR wavebands. (C) 2003 Society of Photo-Optical Instrumentation Engineers. C1 USA, Commun Elect Command, Ctr Res Dev & Engn, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP O'Connor, JD (reprint author), USA, Commun Elect Command, Ctr Res Dev & Engn, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 11 TC 10 Z9 10 U1 1 U2 2 PU SPIE-INT SOCIETY OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD OCT PY 2003 VL 42 IS 10 BP 3047 EP 3052 DI 10.1117/1.1607331 PG 6 WC Optics SC Optics GA 733CM UT WOS:000185982400041 ER PT J AU Rajendran, AM AF Rajendran, AM TI Critical measurements for validation of constitutive equations under shock and impact loading conditions SO OPTICS AND LASERS IN ENGINEERING LA English DT Article ID DYNAMIC FRACTURE; DUCTILE; MANGANIN; SOLIDS; INTERFEROMETER; COMPRESSION; SPALLATION; FAILURE; GAUGES; WAVES AB Interpretation of the data often requires numerical simulations of the experiments and comparisons with the data. However, determination of an appropriate set of values for parameters in constitutive equations valid under shock and high strain rate loading remains one of the most difficult tasks for material model developers. Most researchers employ experimental data obtained under idealized stress/strain states in the model parameter calibration scheme. Since the dynamic response of materials is very complex, especially the failure response, the generality of the model parameters is highly questionable. For example, the fracturing of ceramic materials involves nucleation, propagation, and coalescence of microcracks under shock and impact. The dynamic deformation processes in ceramics include dynamic pore collapse, dislocation generation, twinning, and microcracking. When shocked above the Hugoniot elastic limit, the ceramic deformation becomes inelastic; therefore, the constitutive model formulation should consider modeling the effects of these various processes on the degradation of strength and stiffness of ceramic. This paper presents a brief summary of diagnostic measurements and modeling techniques associated with validation and verification of ceramic constitutive/damage models under high strain rate, shock, and penetration loading applications. (C) 2002 Published by Elsevier Science Ltd. C1 USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Rajendran, AM (reprint author), USA, Res Off, POB 12211, Res Triangle Pk, NC 27709 USA. RI Rajendran, Arunachalam/A-1615-2010 NR 49 TC 5 Z9 6 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0143-8166 J9 OPT LASER ENG JI Opt. Lasers Eng. PD OCT PY 2003 VL 40 IS 4 BP 249 EP 262 AR PII S0143-8166(02)00105-7 DI 10.1016/S0143-8166(02)00105-7 PG 14 WC Optics SC Optics GA 690UD UT WOS:000183567600002 ER PT J AU Polly, DW Ackerman, SJ Shaffrey, CI Ogilvie, JW Wang, JC Stralka, SW Mafilios, MS Heim, SE Sandhu, HS AF Polly, DW Ackerman, SJ Shaffrey, CI Ogilvie, JW Wang, JC Stralka, SW Mafilios, MS Heim, SE Sandhu, HS TI A cost analysis of bone morphogenetic protein versus autogenous iliac crest bone graft in single-level anterior lumbar fusion SO ORTHOPEDICS LA English DT Article ID DONOR-SITE MORBIDITY; SPINAL-FUSION; CERVICAL FUSION; COMPLICATIONS; HARVEST; FRACTURE; AUTOGRAFT; SURGERY; INJURY AB An economic model was developed to compare costs of stand-alone anterior lumbar interbody fusion with recombinant human bone morphogenetic protein 2 on an absorbable collagen sponge versus autogenous iliac crest bone graft in a tapered cylindrical cage or a threaded cortical bone dowel. The economic model was developed from clinical trial data, peer-reviewed literature, and clinical expert opinion. The upfront price of bone morphogenetic protein ($3380) is likely to be offset to a significant extent by reductions in the use of other medical resources, particularly if Costs incurred during the 2-year period following the index hospitalization are taken into account. C1 Walter Reed Army Med Ctr, Orthoped Surg Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Covance Hlth Econ & Outcomes Serv Inc, Gaithersburg, MD USA. Univ Washington, Seattle, WA 98195 USA. Univ Calif Los Angeles, Los Angeles, CA USA. Baptist Rehabil Hosp, Germantown, TN USA. Univ Minnesota, Minneapolis, MN USA. Orthopaed Associates DuPage, New York, NY USA. Hosp Special Surg, New York, NY 10021 USA. RP Polly, DW (reprint author), Walter Reed Army Med Ctr, Orthoped Surg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 49 TC 51 Z9 52 U1 0 U2 2 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD OCT PY 2003 VL 26 IS 10 BP 1027 EP 1037 PG 11 WC Orthopedics SC Orthopedics GA 731QB UT WOS:000185897000005 PM 14577525 ER PT J AU Lafrentz, JR Brietzke, SE Mair, EA AF Lafrentz, JR Brietzke, SE Mair, EA TI Evaluation of palatal snoring surgery in an animal model SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 22nd Midwinter Meeting of the Association-for-Research-in-Otolaryngology CY FEB 13-18, 1999 CL ST PETERSBURG, FLORIDA SP Assoc Res Otolaryngol ID OBSTRUCTIVE SLEEP-APNEA; LASER-ASSISTED UVULOPALATOPLASTY; INJECTION SNOREPLASTY; STIFFENING OPERATION; COMPLICATIONS AB OBJECTIVE. We introduce an animal model to reproduce and measure palatal snoring and to assess the effectiveness of cautery-assisted palatal stiffening operation and injection snoreplasty versus a control (no palatal intervention) on treatment of palatal flutter snoring. STUDY DESIGN AND SETTING: An anesthetized laboratory canine model uses 2 simultaneous temporary tracheotomies. An inferior tracheotomy is cannulated with an endotracheal tube for ventilation. A superior tracheotomy is cannulated with a tube passed cephalad and seated in the hypopharynx. Negative pressure applied to the upper tube leads to partial collapse of the upper airway with palatal fluttering, and the anesthetized dog snores. Videostroboscopy records palatal flutter frequency before and after surgical intervention. Preoperative and postoperative palatal assessments are made on 15 beagles. RESULTS: Cautery-assisted palatal stiffening operation and injection snoreplasty objectively stiffen the canine soft palate with diminished snoring compared with controls. CONCLUSION AND SIGNIFICANCE. We provide a reproducible animal model to experimentally measure new interventions to treat palatal flutter snoring. C1 Walter Reed Army Med Ctr, Otolaryngol Head & Neck Surg Serv, Washington, DC 20307 USA. Armed Forces Radiobiol Res Inst, Washington, DC USA. RP Mair, EA (reprint author), Wilford Hall USAF Med Ctr, Dept Otolaryngol, 2200 Bergquist Dr,Suite 1, San Antonio, TX 78236 USA. NR 15 TC 7 Z9 8 U1 0 U2 2 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD OCT PY 2003 VL 129 IS 4 BP 343 EP 352 DI 10.1016/S0194-5998(03)01389-5 PG 10 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 733XM UT WOS:000186026000006 PM 14574287 ER PT J AU Murphey, YL Jia, HB Del Rose, M AF Murphey, YL Jia, HB Del Rose, M TI Registering real and virtual imagery SO PATTERN RECOGNITION LA English DT Article DE image registration; virtual database; video image; image feature extraction; corresponding points ID LINE CORRESPONDENCES; CAMERA CALIBRATION AB Registering a virtual scene with a real scene captured by a video camera has a number of applications including visually guided robotic navigation, surveillance, military training and operation. The fundamental problem involves several challenging research issues including finding corresponding points between the virtual and the real scene and camera calibration. This paper presents our research in defining and mapping a set of reliable image features for registering the two imageries, extracting and selecting reliable control points for the construction of intrinsic and extrinsic camera parameters. A number of innovative algorithms are presented followed by extensive experimental analysis. An application of registering virtual database image with video image is presented. The algorithms we developed for calculating and matching linear structured features and selecting of reliable control points are applicable to image registration beyond virtual and real imageries. (C) 2003 Pattern Recognition Society. Published by Elsevier Ltd. All rights reserved. C1 Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. USA, TACOM, TARDEC, Vetr Technol Ctr, Washington, DC USA. RP Murphey, YL (reprint author), Univ Michigan, Dept Elect & Comp Engn, 4901 Evergreen Rd 220 ELB, Dearborn, MI 48128 USA. NR 19 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-3203 J9 PATTERN RECOGN JI Pattern Recognit. PD OCT PY 2003 VL 36 IS 10 BP 2363 EP 2375 DI 10.1016/S0031-3203(03)00053-0 PG 13 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 707KN UT WOS:000184510000013 ER PT J AU Barrickman, L AF Barrickman, L TI Disruptive behavioral disorders SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Article ID OPPOSITIONAL DEFIANT DISORDER; DEFICIT HYPERACTIVITY DISORDER; CONDUCT DISORDER; FOLLOW-UP; PSYCHOPATHOLOGY; ADOLESCENCE; CHILDHOOD; PREVALENCE; DIAGNOSIS; CHILDREN AB The disruptive behavioral disorders (DBD) include: (1) oppositional defiant disorder (ODD); (2) three types of conduct disorders (CD), which are dependant on and defined by the age of onset; and (3) disruptive behavior disorder not otherwise specified (DBD-NOS) [1]. Most DBD cases are present and usually evident in early childhood or adolescence. Reviews of literature demonstrate that they represent one of the most frequently encountered groups of child and adolescent psychiatric disorders [2]. Numerous studies have found CD to be the most common reason for referral of children and adolescents for psychiatric evaluations [3]. The Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition - Text Revision (DSM-IV-TR) defines the essential feature of ODD as a recurrent pattern of behavior persisting at least 6 months with negativity, defiance, disobedience, and hostility directed toward authority figures. DSM-IV-TR defines the essential feature of CD as a persistent and repetitive pattern of behavior lasting at least 12 months in which the basic rights of others or major age-appropriate societal norms or rules are violated. DSM-IV-TR defines DBD-NOS as the diagnosis for those individuals who do not meet the criteria for ODD or CD with a pattern of significant oppositional and conduct behaviors [1]. Frequently, these behaviors create more disruption, disturbance, and distress for other people than for those who cause or create it. ODD behavior and symptoms present primarily as verbal (eg, verbal aggression and defiance). ODD crosses over to CD when behavior and symptoms become physical (eg, fighting, destruction, and stealing). Frequently, individuals with a CD diagnosis will meet diagnostic criteria for ODD. The reverse is not true; those individuals with a diagnosis of ODD are not able to meet diagnostic criteria for CD. Subsequently, as stated in DSM, if or when an individual demonstrates the ability to satisfy diagnostic criteria for ODD and CD, the CD diagnosis preempts the diagnosis of ODD, and therefore, only a CD diagnosis is given [1]. In clinics, an individual who meets criteria for CD will almost always meet criteria for ODD. C1 Univ Hawaii, Sch Med, Div Child & Adolescent Psychiat, Honolulu, HI 96813 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Barrickman, L (reprint author), Univ Hawaii, Sch Med, Div Child & Adolescent Psychiat, 1356 Lusitana St,4th Floor, Honolulu, HI 96813 USA. NR 31 TC 2 Z9 2 U1 3 U2 5 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD OCT PY 2003 VL 50 IS 5 BP 1005 EP + DI 10.1016/S0031-3955(03)00078-6 PG 15 WC Pediatrics SC Pediatrics GA 727MN UT WOS:000185662800003 PM 14558679 ER PT J AU Perovich, DK AF Perovich, DK TI Complex yet translucent: The optical properties of sea ice SO PHYSICA B-CONDENSED MATTER LA English DT Article; Proceedings Paper CT 6th International Conference on Electrical Transport and Optical Properties of Inhomogeneous Media CY JUL 15-19, 2002 CL SNOWBIRD, UTAH SP Natl Sci Fdn, USA Res Off, Univ Utah, Opt Soc Amer, Amer Phys Soc, Soc Ind & Appl Math DE sea ice; optical properties; albedo ID ABSORPTION-COEFFICIENTS; MODEL; CLIMATE; NM; RADIATION AB Sea ice is a naturally occurring material with an intricate and highly variable structure consisting of ice platelets, brine pockets, air bubbles, and precipitated salt crystals. The optical properties of sea ice are directly dependent on this ice structure. Because sea ice is a material that exists at its salinity determined freezing point, its structure and optical properties are significantly affected by small changes in temperature. Understanding the interaction of sunlight with sea ice is important to a diverse array of scientific problems, including those in polar climatology. A key optical parameter for climatological studies is the albedo, the fraction of the incident sunlight that is reflected. The albedo of sea ice is quite sensitive to surface conditions. The presence of a snow cover enhances the albedo, while surface meltwater reduces the albedo. Radiative transfer in sea ice is a combination of absorption and scattering. Differences in the magnitude of sea ice optical properties are ascribable primarily to differences in scattering, while spectral variations are mainly a result of absorption. Physical changes that enhance scattering, such as the formation of air bubbles due to brine drainage, result in more light reflection and less transmission. Published by Elsevier B.V. C1 USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Perovich, DK (reprint author), USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. NR 41 TC 11 Z9 13 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4526 J9 PHYSICA B JI Physica B PD OCT PY 2003 VL 338 IS 1-4 BP 107 EP 114 DI 10.1016/S0921-4526(03)00470-8 PG 8 WC Physics, Condensed Matter SC Physics GA 747PB UT WOS:000186812200023 ER PT J AU Pushkarev, A Resio, D Zakharov, V AF Pushkarev, A Resio, D Zakharov, V TI Weak turbulent approach to the wind-generated gravity sea waves SO PHYSICA D-NONLINEAR PHENOMENA LA English DT Article; Proceedings Paper CT Conference on Complexity and Nonlinearity in Physical Systems held in Honor of Alan Newell CY NOV, 2001 CL UNIV ARIZONA, TUCSON, ARIZONA HO UNIV ARIZONA DE weak turbulent theory; Kolmogorov spectrum; Quasi-stationary wave spectrum ID LINEAR ENERGY-TRANSFER; EQUILIBRIUM RANGE; CAPILLARY WAVES; SPECTRUM; SURFACE; FLUXES; MODEL; FETCH; FLUID AB We performed numerical simulation of the kinetic equation describing behavior of an ensemble of random-phase, spatially homogeneous gravity waves on the surface of the infinitely deep ocean. Results of simulation support the theory of weak turbulence not only in its basic points, but also in many details. The weak turbulent theory predicts that the main physical processes taking place in the wave ensemble are down-shift of spectral peak and "leakage" of energy and momentum to the region of very small scales where they are lost due to local dissipative processes. Also, the spectrum of energy right behind the spectral peak should be close to the weak turbulent Kolmogorov spectrum which is the exact solution of the stationary kinetic (Hasselmann) equation. In a general case, this solution is anisotropic and is defined by two parameters-fluxes of energy and momentum to high wave numbers. Even in the anisotropic case the solution in the high wave number region is almost proportional to the universal form omega(-4). This result should be robust with respect to change of the parameters of forcing and damping. In all our numerical experiments, the omega(-4) Kolmogorov spectrum appears in very early stages and persists in both stationary and non-stationary stages of spectral development. A very important aspect of the simulations conducted here was the development of a quasi-stationary wave spectrum under wind forcing, in absence of any dissipation mechanism in the spectral peak region. This equilibrium is achieved in the spectral range behind the spectral peak due to compensation of wind forcing and leakage of energy and momentum to high wave numbers due to nonlinear four-wave interaction. Numerical simulation demonstrates slowing down of the shift of the spectral peak and formation of the bimodal angular distribution of energy in the agreement with field and laboratory experimental data. A more detailed comparison with the experiment can be done after developing of an upgraded code making possible to model a spatially inhomogeneous ocean. (C) 2003 Elsevier B.V. All rights reserved. C1 Waves & Solit LLC, Phoenix, AZ 85045 USA. US Army Engineer Res & Dev Ctr, Costal & Hydraul Lab, Vicksburg, MS 39180 USA. LD Landau Theoret Phys Inst, Moscow 117334, Russia. Univ Arizona, Dept Math, Tucson, AZ 85721 USA. RP Zakharov, V (reprint author), Waves & Solit LLC, 918 W Windsong Dr, Phoenix, AZ 85045 USA. RI Pushkarev, Andrei/I-8290-2016; OI Pushkarev, Andrei/0000-0001-9310-5888; zakharov, vladimir/0000-0001-8855-7185 NR 41 TC 34 Z9 34 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2789 J9 PHYSICA D JI Physica D PD OCT 1 PY 2003 VL 184 IS 1-4 BP 29 EP 63 DI 10.1016/S0167-2789(03)00212-4 PG 35 WC Mathematics, Applied; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA 735PK UT WOS:000186123600004 ER PT J AU D'Aguanno, G Centini, M Scalora, M Sibilia, C Bertolotti, M Fazio, E Bowden, CM Bloemer, MJ AF D'Aguanno, G Centini, M Scalora, M Sibilia, C Bertolotti, M Fazio, E Bowden, CM Bloemer, MJ TI Slowing light in chi((2)) photonic crystals SO PHYSICAL REVIEW E LA English DT Article ID ATOMIC GAS AB A study of parametric nonlinear frequency down-conversion in photonic crystals reveals that under suitable conditions the probe field can be slowed down to approximately 11 m/s. The effect arises as a result of the simultaneous availability of global phase-matching conditions, field localization, and gain experienced by the probe beam. Together, these effects conspire to yield tunneling velocities previously reported only for coherently resonant interactions, i.e., electromagnetic induced transparency, in Bose-Einstein condensates, hot atomic gases, and doped crystals. C1 Univ Roma La Sapienza, INFM, I-00161 Rome, Italy. Univ Roma La Sapienza, Dipartimento Energet, I-00161 Rome, Italy. USA, Weap Sci Directorate, Ctr Res Dev & Engn, Aviat & Missile Command, Redstone Arsenal, AL 35898 USA. RP Univ Roma La Sapienza, INFM, Via A Scarpa 16, I-00161 Rome, Italy. EM giuseppe.daguanno@uniromal.it NR 16 TC 3 Z9 3 U1 0 U2 0 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD OCT PY 2003 VL 68 IS 4 AR 046613 DI 10.1103/PhysRevE.68.046613 PN 2 PG 4 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 743KP UT WOS:000186571200085 PM 14683071 ER PT J AU Yenesew, A Derese, S Midiwo, JO Oketch-Rabah, HA Lisgarten, J Palmer, R Heydenreih, M Peter, MG Akala, H Wangui, J Liyala, P Waters, NC AF Yenesew, A Derese, S Midiwo, JO Oketch-Rabah, HA Lisgarten, J Palmer, R Heydenreih, M Peter, MG Akala, H Wangui, J Liyala, P Waters, NC TI Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis SO PHYTOCHEMISTRY LA English DT Article DE Millettia usaramensis subspecies usaramensis; Leguminosae; stem bark; rotenoids; usararotenoid A; 12-dihydrousararotenoid A; usararotenoid C; NMR; CD; X-ray; anti-plasmodial; malaria; Plasmodium falciparum ID SEED PODS; ISOFLAVONES; DURA; RESISTANCE; FALCIPARUM; CHALCONES; INVITRO AB The dichloromethane extract of the stem bark of Millettia usaramensis subspecies usaramensis showed anti-plasmodial activity against the chloroquine sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the identification of a new rotenoid, (6aR,12aS)-2,3-methylenedioxy-9-methoxy-8-(3,3-dimethylallyl)-12a-hydroxyrotenoid (trivial name, usararotenoid C) along with known flavonoids (usararotenoid A, 12a-epimillettosin, 6a, 12a-dehydromillettone, barbigerone and 4'-O-geranylisoliquiritigenin) as the anti-plasmodial principles. The structures were determined by spectroscopic analyses. CD and X-ray analyses established absolute configurations. (C) 2003 Elsevier Ltd. All rights reserved. C1 Univ Nairobi, Dept Chem, Nairobi, Kenya. Univ Nairobi, Dept Pharmacol & Pharmacognosy, Nairobi, Kenya. Univ London Birkbeck Coll, Dept Crystallog, London WC1E 7HX, England. Univ Potsdam, Inst Chem, D-14415 Potsdam, Germany. USA, Med Res Unit Kenya, MRU 64109, APO, AE 09831 USA. RP Yenesew, A (reprint author), Univ Nairobi, Dept Chem, POB 30197, Nairobi, Kenya. EM ayenesew@uonbi.ac.ke OI Derese, Solomon/0000-0002-2640-3583; Heydenreich, Matthias/0000-0003-1639-4959 NR 22 TC 39 Z9 44 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9422 J9 PHYTOCHEMISTRY JI Phytochemistry PD OCT PY 2003 VL 64 IS 3 BP 773 EP 779 DI 10.1016/S0031-9422(03)00373-X PG 7 WC Biochemistry & Molecular Biology; Plant Sciences SC Biochemistry & Molecular Biology; Plant Sciences GA 729WE UT WOS:000185797400014 PM 13679101 ER PT J AU Samet, ED AF Samet, ED TI Spectacular history and politics of the theater: Sympathetic arts in the shadow of the Bastille SO PMLA-PUBLICATIONS OF THE MODERN LANGUAGE ASSOCIATION OF AMERICA LA English DT Article ID BURKE C1 US Mil Acad, W Point, NY 10996 USA. RP Samet, ED (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 44 TC 4 Z9 4 U1 0 U2 0 PU MODERN LANGUAGE ASSOC AMER PI NEW YORK PA 10 ASTOR PLACE, NEW YORK, NY 10003 USA SN 0030-8129 J9 PMLA JI PMLA-Publ. Mod. Lang. Assoc. Am. PD OCT PY 2003 VL 118 IS 5 BP 1305 EP 1319 DI 10.1632/003081203X67974 PG 15 WC Literature SC Literature GA 726PJ UT WOS:000185607800005 ER PT J AU Kondratieff, BC Kirchner, RF AF Kondratieff, BC Kirchner, RF TI Two new species of Perlesta Banks (Plecoptera : Perlidae) from eastern North America SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article DE Plecoptera : Perlidae; Perlesta; new species; Nearctic; Virginia ID COMPLEX PLECOPTERA; PLACIDA HAGEN; VIRGINIA; STONEFLIES; ILLINOIS AB Two new species in the Nearctic perlid stonefly genus Perlesta Banks are described from Virginia, USA. Perlesta roblei, n. sp., is described from Middlesex and King and Queen counties, and P. puttmanni, n. sp., is described from Hanover, Pittsylvania, and Prince William counties. The adult male, adult female, and egg are described and illustrated for both species. C1 Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA. USA, Corps Engineers, Water Qual Sect, Apple Grove, WV 25502 USA. RP Kondratieff, BC (reprint author), Colorado State Univ, Dept Bioagr Sci & Pest Management, Ft Collins, CO 80523 USA. NR 13 TC 2 Z9 3 U1 0 U2 0 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD OCT PY 2003 VL 105 IS 4 BP 933 EP 939 PG 7 WC Entomology SC Entomology GA 732WV UT WOS:000185969300014 ER PT J AU Robbins, RG Deem, SL Noss, AJ Greco, V AF Robbins, RG Deem, SL Noss, AJ Greco, V TI First report of Amblyomma pseudoconcolor aragao (Acari : Ixodida : Ixodidae) from Bolivia, with a new record of this tick from the grey brocket deer, Mazama gouazoupira (G. Fischer) (Mammalia : Artiodactyla : Cervidae) SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article C1 Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. Wildlife Conservat Soc, Field Vet Program, Bronx, NY 10460 USA. Wildlife Conservat Soc Bolivia, Santa Cruz, Bolivia. RP Robbins, RG (reprint author), Walter Reed Army Med Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. NR 10 TC 2 Z9 2 U1 0 U2 2 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD OCT PY 2003 VL 105 IS 4 BP 1053 EP 1055 PG 3 WC Entomology SC Entomology GA 732WV UT WOS:000185969300025 ER PT J AU Robinson, JD Habben, CJ AF Robinson, JD Habben, CJ TI The role of the American Board of Professional Psychology in professional mobility SO PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE LA English DT Article AB This article describes the role of certification by the American Board of Professional Psychology (ABPP) in easing the process by which psychologists move beyond their original jurisdictional boundaries to practice psychology. Meeting the requirements for licensure or certification in the various jurisdictions can be a difficult task because these requirements vary considerably from jurisdiction to jurisdiction. Other mechanisms that are available to facilitate this process include the Certificate of Professional Qualification in Psychology issued by the Association of State and Provincial Psychology Boards and certification by the National Register of Health Service Providers in Psychology. The ABPP certificate/diploma has been regarded by many state psychological associations and state boards of psychology as an appropriate way in which to recognize psychologists who are eligible for licensure/certification in a jurisdiction because of the examination requirements for board certification. C1 Howard Univ Hosp, Coll Med, Dept Surg, Washington, DC 20060 USA. Georgetown Univ, Sch Med, Washington, DC 20057 USA. Walter Reed Army Med Ctr, Behav Hlth Clin, Washington, DC 20307 USA. RP Robinson, JD (reprint author), Howard Univ Hosp, Coll Med, Dept Surg, 2041 Georgia Ave,NW, Washington, DC 20060 USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0735-7028 J9 PROF PSYCHOL-RES PR JI Prof. Psychol.-Res. Pract. PD OCT PY 2003 VL 34 IS 5 BP 474 EP 475 DI 10.1037/0735-7028.34.5.474 PG 2 WC Psychology, Multidisciplinary SC Psychology GA 725QN UT WOS:000185554000004 ER PT J AU Howard, SL AF Howard, SL TI Flash tube lacquer seal dynamic rupture strength in 30-mm ammunition SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE ignition studies; laser ignition; black powder; medium-caliber gun; flash tube AB The M788, M789, and M799 30-mm ammunition use a flash tube to augment the ignition stimulus of the primer and to provide an ignition source for the propellant bed in each round. The flash tube must be fast acting, provide abundant hot gases/particles, and increase the pressure in the propellant bed sufficiently so that the initial burn rate of the propellant in the bed is high enough to propel the projectile to the muzzle within the few milliseconds that constitute the action time of the M230 cannon. This investigation studied the dynamic rupture pressure of the lacquer seal on the flash tube. The rupture pressure of the seal was found to be a function of the pressurization rate in the flash tube. At the largest rupture pressure of this study (78 MPa), significant gas generation would be achieved before the flash tube vented into the main propellant bed. Gas flow at these pressures is expected to play a significant role in ignition of the main propellant charge and rapid functioning of the round. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Howard, SL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD OCT PY 2003 VL 28 IS 5 BP 256 EP 258 DI 10.1002/prep.200300013 PG 3 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 741RF UT WOS:000186470500005 ER PT J AU Somiari, RI Sullivan, A Russell, S Somiari, S Hu, H Jordan, R George, A Katenhusen, R Buchowiecka, A Arciero, C Brzeski, H Hooke, J Shriver, C AF Somiari, RI Sullivan, A Russell, S Somiari, S Hu, H Jordan, R George, A Katenhusen, R Buchowiecka, A Arciero, C Brzeski, H Hooke, J Shriver, C TI High-throughput proteomic analysis of human infiltrating ductal carcinoma of the breast SO PROTEOMICS LA English DT Article DE high-throughput proteomics; infiltrating ductal carcinoma; two-dimensional difference gel electrophoresis ID GENE-EXPRESSION SIGNATURE; IMMOBILIZED PH GRADIENTS; 2-DIMENSIONAL ELECTROPHORESIS; GEL-ELECTROPHORESIS; MASS-SPECTROMETRY; DOWN-REGULATION; CANCER-CELLS; IN-SITU; PROTEIN; IDENTIFICATION AB Large-scale proteomics will play a critical role in the rapid display, identification and validation of new protein targets, and elucidation of the underlying molecular events that are associated with disease development, progression and severity. However, because the proteome of most organisms are significantly more complex than the genome, the comprehensive analysis of protein expression changes will require an analytical effort beyond the capacity of standard laboratory equipment. We describe the first high-throughput proteomic analysis of human breast infiltrating ductal carcinoma (IDCA) using OCT (optimal cutting temperature) embedded biopsies, two-dimensional difference gel electrophoresis (2-D DIGE) technology and a fully automated spot handling workstation. Total proteins from four breast IDCAs (Stage I, IIA, IIB and IIIA) were individually compared to protein from non-neoplastic tissue obtained from a female donor with no personal or family history of breast cancer. We detected differences in protein abundance that ranged from 14.8% in stage I IDCA versus normal, to 30.6% in stage IIB IDCA versus normal. A total of 524 proteins that showed greater than or equal to three-fold difference in abundance between IDCA and normal tissue were picked, processed and identified by mass spectrometry. Out of the proteins picked, similar to80% were unambiguously assigned identities by matrix-assisted laser desorbtion/ionization-time of flight mass spectrometry or liquid chromatography-tandem mass spectrometry in the first pass. Bioinformatics tools were also used to mine databases to determine if the identified proteins are involved in important pathways and/or interact with other proteins. Gelsolin, vinculin, lumican, alpha-1-antitrypsin, heat shock protein-60, cytokeratin-18, transferrin, enolase-1 and beta-actin, showed differential abundance between IDCA and normal tissue, but the trend was not consistent in all samples. Out of the proteins with database hits, only heat shock protein-70 (more abundant) and peroxiredoxin-2 (less abundant) displayed the same trend in all the IDCAs examined. This preliminary study demonstrates quantitative and qualitative differences in protein abundance between breast IDCAs and reveals 2-D DIGE portraits that may be a reflection of the histological and pathological status of breast IDCA. C1 Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. Walter Reed Army Med Ctr, Gen Surg Serv, Washington, DC 20307 USA. RP Somiari, RI (reprint author), Windber Res Inst, Clin Breast Care Project, 600 Somerset Ave, Windber, PA 15963 USA. NR 41 TC 117 Z9 129 U1 0 U2 7 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1615-9853 J9 PROTEOMICS JI Proteomics PD OCT PY 2003 VL 3 IS 10 BP 1863 EP 1873 DI 10.1002/pmic.200300560 PG 11 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 736JW UT WOS:000186168500003 PM 14625848 ER PT J AU Sturm, M Perovich, DK Serreze, MC AF Sturm, M Perovich, DK Serreze, MC TI Meltdown in the North SO SCIENTIFIC AMERICAN LA English DT Article C1 USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Sturm, M (reprint author), USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. NR 4 TC 8 Z9 11 U1 1 U2 13 PU SCI AMERICAN INC PI NEW YORK PA 415 MADISON AVE, NEW YORK, NY 10017 USA SN 0036-8733 J9 SCI AM JI Sci.Am. PD OCT PY 2003 VL 289 IS 4 BP 60 EP 67 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 721DX UT WOS:000185302700029 PM 14513519 ER PT J AU Hsieh, YH Howell, MR Gaydos, JC McKee, KT Quinn, TC Gaydos, CA AF Hsieh, YH Howell, MR Gaydos, JC McKee, KT Quinn, TC Gaydos, CA TI Preference among female army recruits for use of self-administrated vaginal swabs or urine to screen for Chlamydia trachomatis genital infections SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID LIGASE CHAIN-REACTION; NEISSERIA-GONORRHOEAE INFECTION; SEXUALLY-TRANSMITTED DISEASES; HUMAN-PAPILLOMAVIRUS; DNA AMPLIFICATION; REACTION ASSAY; WOMEN; DIAGNOSIS; SAMPLES; COLLECTION AB Background: Use of self-administered vaginal swabs (SAS) for the detection of Chlamydia trachomatis by nucleic acid amplification tests simplifies specimen collection and transport, especially for women in nonclinical settings. Goal: We investigated the preference and comfort level of military women for the collection of SAS, compared with urine, for the diagnosis of genital chlamydial infections. Study Design: During March through August 1999, female Army recruits in basic training at Fort Jackson, South Carolina, were invited to participate in the study. Participants were requested to complete a questionnaire after providing both first-void urine (FVU) and SAS specimens. Participant characteristics, preferences, and comfort levels were assessed using multivariate logistic regression. Results: From 4496 eligible female recruits, 1403 (31%) completed questionnaires and 1382 provided both specimens; 11.8% (166 of 1403) of participants were infected with chlamydia. The relative sensitivity and specificity of the C. trachomatis Ligase Chain Reaction test on SAS in 1382 matched pairs was 81.1% and 98.6%, respectively, using the test result on urine specimens as the comparison standard. Most of the participants (90.8%) reported that they felt comfortable collecting the FVU specimen, and 69.6% indicated that they felt comfortable collecting SAS. Either specimen collection type received high acceptability at home and in the field, and more women reported that they would collect FVU than reported they would collect SAS in the future (in the field: FVU: 79.4%, SAS: 68.8%, P < 0.001); at home: FVU: 90.9%, SAS: 82.9%, P < 0.001). When questioned about ease of use, 60.4% of women reported that urine was the easier method. Preferences for SAS were associated with being white and having had sexual risk behaviors in the past 3 months. Conclusion: A study of preferences for urine versus self-administered vaginal swabs for the detection of C. trachomatis in military women showed that women generally found SAS acceptable. SAS should be a feasible alternative to urine collection in situations in which specimen storage or transport is an issue. C1 Johns Hopkins Univ, Sch Med, Div Infect Dis, Baltimore, MD USA. Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, Tainan 70101, Taiwan. US Dept Def, Global Emerging Infect Surveillance & Response Sy, Silver Spring, MD USA. Womack Army Med Ctr, Ft Bragg, NC USA. NIAID, NIH, Bethesda, MD 20892 USA. RP Gaydos, CA (reprint author), 1159 Ross,720 Rutland Ave, Baltimore, MD USA. RI Gaydos, Charlotte/E-9937-2010 NR 35 TC 43 Z9 46 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD OCT PY 2003 VL 30 IS 10 BP 769 EP 773 DI 10.1097/01.OLQ.0000079048.11771.46 PG 5 WC Infectious Diseases SC Infectious Diseases GA 728LZ UT WOS:000185719800007 PM 14520176 ER PT J AU Szebeni, J Baranyi, L Savay, S Gotze, O Alving, CR Bunger, R Mongan, PD AF Szebeni, J Baranyi, L Savay, S Gotze, O Alving, CR Bunger, R Mongan, PD TI Complement activation during hemorrhagic shock and resuscitation in swine SO SHOCK LA English DT Article DE anaphylatoxins; endotoxin; thromboxane; trauma; Ringer's lactate; plasma expanders; ischemia/reperfusion injury; lactic acidosis ID LIPOSOME-ENCAPSULATED HEMOGLOBIN; MULTIPLE ORGAN FAILURE; IN-VITRO ACTIVATION; C-REACTIVE-PROTEIN; ALTERNATIVE PATHWAY; NATURAL ANTIBODY; LACTIC-ACIDOSIS; TISSUE-INJURY; INHIBITION; MODEL AB Activation of the complement (C) cascade is known to play a key role in the adverse immune consequences of hemorrhagic trauma with subsequent shock and resuscitation. However, it is not clear whether hypovolemia per se, without trauma and resuscitation, can also lead to C activation. To address this question, we studied the presence, kinetics, and cause of C activation in a porcine model of hemorrhagic shock and resuscitation in the absence of trauma. Pigs were bled to and kept at 35 mmHg for 90 min, followed by hypotensive resuscitation with different fluids and, finally, with shed blood. The animals developed severe lactic acidosis between 30 and 90 min, which was accompanied by a trend for initial rise and subsequent 40% drop of CH50/mL, indicating massive C activation even before resuscitation, i.e., before reperfusion damage could have occurred. Resuscitation with plasma expanders caused 20% additional C consumption, whereas whole blood raised CH50/mL. Plasma C5a decreased initially and then significantly increased at 60 and 180 min, whereas thromboxane B-2 showed a 3-fold increase at 30 and 60 min. Plasma LIPS was also increased above baseline at 90 and 180 min. In in vitro studies with pig blood, spontaneous C5a formation, as well as zymosan-induced C consumption, was significantly enhanced under the conditions of lactic acidosis. Our data suggest that lactic acidosis, endotoxemia, and possibly other ischemia-related tissue alterations act in a vicious cycle in inducing C activation and, hence, aggravation of shock. The biphasic course of CH50/mL and C5a changes may reflect yet unrecognized physiological responses to hemorrhage-related C activation. C1 Walter Reed Army Inst Res, Dept Membrane Biochem, Washington, DC 20307 USA. Inst Res, Washington, DC 20307 USA. Univ Gottingen, Dept Immunol, D-37075 Gottingen, Germany. Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Rockville, MD 20852 USA. Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Rockville, MD 20852 USA. RP Szebeni, J (reprint author), Walter Reed Army Inst Res, Dept Membrane Biochem, Washington, DC 20307 USA. NR 35 TC 31 Z9 32 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD OCT PY 2003 VL 20 IS 4 BP 347 EP 355 DI 10.1097/01.shk.0000082444.66379.17 PG 9 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 723QE UT WOS:000185442400009 PM 14501949 ER PT J AU Watson, S AF Watson, S TI Valor across the lone star: The Congressional Medal of Honor in frontier Texas. SO SOUTHWESTERN HISTORICAL QUARTERLY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TEXAS STATE HIST ASSN PI AUSTIN PA 2/306 RICHARDSON HALL UNIV STATION, AUSTIN, TX 78712 USA SN 0038-478X J9 SOUTHWEST HIST QUART JI Southw. Hist. Q. PD OCT PY 2003 VL 107 IS 2 BP 340 EP 340 PG 1 WC History SC History GA 753NU UT WOS:000187238100013 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of tetraazidogermane SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; tetraazidogermanium; germanium azide ID DENSITY; SPECTRA AB The vibrational frequencies and corresponding normal mode assignments of tetraazidogermane are examined theoretically using the Gaussian98 set of quantum chemistry codes. All normal modes were successfully assigned to one of seven types of motion predicted by a group theoretical analysis (N-N-N asymmetric stretch, N-N-N symmetric stretch, Ge-N stretch, N-N-N bend, Ge-N-N bend, N-Ge-N bend, and N-Ge-N-N torsion) utilizing the S-4 symmetry of the molecule. The molecular orbitals of Ge(N-3)(4) are examined. Published by Elsevier Science B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSSB, RRT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSSB, RRT,DP, Aberdeen Proving Ground, MD 21010 USA. NR 22 TC 5 Z9 5 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1386-1425 J9 SPECTROCHIM ACTA A JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. PD OCT PY 2003 VL 59 IS 12 BP 2805 EP 2814 DI 10.1016/S1386-1425(03)00105-7 PG 10 WC Spectroscopy SC Spectroscopy GA 728LX UT WOS:000185719600016 PM 14499842 ER PT J AU Watts, RJ Porter, AL AF Watts, RJ Porter, AL TI R&D cluster quality measures and technology maturity SO TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE LA English DT Article; Proceedings Paper CT International Symposium on Forecasting (ISF) CY JUN, 2002 CL DUBLIN, IRELAND DE R&D cluster quality measures; technology maturity; innovation indicators AB "Innovation indicators" strive to track the maturation of an emerging technology to help forecast its prospective development. One rich source of information is the changing content of discourse of R&D, as the technology progresses. We analyze the content of research paper abstracts obtained by searching large databases on a given topic. We then map the evolution of that topic's emphasis areas. The present research seeks to validate a process that creates factors (clusters) based on term usage in technical papers. Three composite quality measures-cohesion, entropy, and F measure-are computed. Using these measures, we create standard factor groupings that optimize the composite term sets and facilitate comparisons of the R&D emphasis areas (i.e., clusters) over time. The conceptual foundation for this approach lies in the presumption that domain knowledge expands and becomes more application specific in nature as a technology matures. We hypothesize implications for this knowledge expansion in terms of the three factor measures, then observe these empirically for the case of a particular technology-autonomous navigation. These metrics can provide indicators of technological maturation. Published by Elsevier Science Inc. C1 USA, Tank Automot & Armaments Command, Adv Vehicle Technol, Warren, MI 48397 USA. Search Technol Inc, Norcross, GA 30071 USA. Georgia Inst Technol, Technol Policy & Assessment Ctr, Atlanta, GA 30332 USA. RP Watts, RJ (reprint author), USA, Tank Automot & Armaments Command, Adv Vehicle Technol, Warren, MI 48397 USA. NR 19 TC 17 Z9 18 U1 0 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0040-1625 J9 TECHNOL FORECAST SOC JI Technol. Forecast. Soc. Chang. PD OCT PY 2003 VL 70 IS 8 BP 735 EP 758 DI 10.1016/S0040-1625(02)00355-4 PG 24 WC Business; Planning & Development SC Business & Economics; Public Administration GA 719QW UT WOS:000185216500003 ER PT J AU Gross, CL Nealley, EW Smith, WJ Corun, CM Nipwoda, MT AF Gross, CL Nealley, EW Smith, WJ Corun, CM Nipwoda, MT TI A rapid colorimetric assay for sulfur mustard cytotoxicity using isolated human peripheral blood lymphocytes and keratinocytes SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE chromogenic; MTS; sulfur mustard; viability ID TOXICITY; INVITRO AB Sulfur mustard (SM) is a potent vesicating agent that has pronounced cytotoxic effects as well as mutagenic, carcinogenic, and radiomimetic properties. Isolated human peripheral blood lymphocytes (PBLs) and human epidermal keratinocytes (HEKs) have been used as in vitro models for determining SM-induced cytotoxicity. A recently developed colorimetric assay (the CellTiter 96 AQ(ueous). Non-radioactive Cell Proliferation Assay) was assessed using both of the in vitro models described above. Using 24- or 96-well microplates, reproducible (+/-10%) SM dose/response curves for both types of human cells were obtained using a spectrophotometric microplate reader set at 490 mu. After a 4-h incubation time, as many as 96 sample wells could be measured within 45 s using this commonly available equipment. Multiple plates of samples can be run immediately. This technique may facilitate cytotoxicity investigations of new candidate compounds for both prophylaxis of and therapy for SM intoxication. C1 USA, Med Res Inst Chem Def, Div Pharmacol, Aberdeen Proving Ground, MD 21010 USA. USA, Med Res Inst Chem Def, Drug Assessment Div, Aberdeen Proving Ground, MD 21010 USA. RP Gross, CL (reprint author), Biochem Pharmacol, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM clark.gross@apg.amedd.army.mil NR 12 TC 3 Z9 3 U1 1 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD OCT-DEC PY 2003 VL 13 IS 4 BP 263 EP 268 DI 10.1080/713857190 PG 6 WC Toxicology SC Toxicology GA 745QN UT WOS:000186699700004 PM 20021151 ER PT J AU Bolan, CD Wesley, RA Yau, YY Cecco, SA Starling, J Oblitas, JM Rehak, NN Leitman, SF AF Bolan, CD Wesley, RA Yau, YY Cecco, SA Starling, J Oblitas, JM Rehak, NN Leitman, SF TI Randomized placebo-controlled study of oral calcium carbonate administration in plateletpheresis: I. Associations with donor symptoms SO TRANSFUSION LA English DT Article ID IONIZED CALCIUM; PARATHYROID-HORMONE; CITRATE; INFUSION; PLATELETAPHERESIS; TESTS AB BACKGROUND: The effect of oral calcium (Ca) supplements in preventing citrate-induced symptoms during plateletpheresis was evaluated in a randomized, blinded, placebo-control led trial. STUDY DESIGN AND METHODS: Twenty-three donors (12 men, 11 women) underwent four plateletpheresis procedures each, ingesting either 1 or 2 g of oral Ca carbonate or an equivalent placebo 30 minutes before donation. Ten of these subjects subsequently ingested 4 g of open-label Ca before a fifth procedure. All procedures were conducted at the same citrate infusion rate (1.5 mg/kg/min) for 90 minutes. RESULTS: Ingestion of 2 g of oral Ca resulted in a significant reduction in the severity of paresthesias and a significant, though modest, increase in serum ionized calcium (iCa), but no significant improvement in total symptom scores, compared to placebo. Minimal effects were seen with the 1-g dose. The two factors most highly correlated with development of severe symptoms were decreased levels of iCa and ionized magnesium (iMg) at 30 minutes into apheresis. Lower preapheresis serum albumin, creatinine, vitamin D, iMg, and total Mg concentrations were also significantly associated with symptoms. Women experienced more frequent and severe symptoms than men, however, gender was not associated with symptoms after adjustment for lower serum albumin, creatinine, and Mg levels. Ingestion of 4 g of Ca offered no improvement in symptoms or iCa levels compared with the 2-g dose. CONCLUSION: Prophylactic oral Ca was associated with modest improvements in citrate-induced symptoms and laboratory parameters. Baseline albumin and Mg levels were strongly predictive of the development of symptoms. In donors with a prior history of uncomfortable citrate-related effects, a 2-g oral Ca dose before apheresis is recommended. C1 NIH, Dept Transfus Med, Biostat Serv, Dept Lab Med, Bethesda, MD 20892 USA. NIH, Pharm Dept, Warren Grand Magnuson Clin Ctr, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Leitman, SF (reprint author), NIH, Dept Transfus Med, Biostat Serv, Dept Lab Med, Bldg 10,Rm 1C711,10 Ctr Dr,MSC 1184, Bethesda, MD 20892 USA. NR 19 TC 23 Z9 27 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD OCT PY 2003 VL 43 IS 10 BP 1403 EP 1413 DI 10.1046/j.1537-2995.2003.00514.x PG 11 WC Hematology SC Hematology GA 726NY UT WOS:000185606800011 PM 14507272 ER PT J AU Bolan, CD Cecco, SA Yau, YY Wesley, RA Oblitas, JM Rehak, NN Leitman, SE AF Bolan, CD Cecco, SA Yau, YY Wesley, RA Oblitas, JM Rehak, NN Leitman, SE TI Randomized placebo-controlled study of oral calcium carbonate supplementation in plateletpheresis: II. Metabolic effects SO TRANSFUSION LA English DT Article ID PARATHYROID-HORMONE; IONIZED CALCIUM; CITRATE; PLATELETAPHERESIS; ABSORPTION; INFUSION; SALTS AB BACKGROUND: The metabolic effects of oral calcium (Ca) supplementation during plateletpheresis were evaluated in a randomized, placebo-controlled trial. STUDY DESIGN AND METHODS: Twenty-three donors underwent four plateletpheresis procedures each, receiving in random order, elemental Ca (Ca) 1 or 2 g orally, or a corresponding placebo, 30 minutes before donation. Ten of these donors underwent a fifth procedure using a 4-g Ca dose. All procedures were performed at a fixed citrate infusion rate of 1.5 mg per kg per minute. RESULTS: Oral Ca induced dose-sensitive changes in parathyroid hormone (iPTH), total (tCa), and ionized (iCa) calcium levels. Compared to placebo, the greatest improvement in tCa and iCa levels occurred after the 2-g Ca dose (tCa of 73, 89, and 25% above placebo levels at 60 min, using 1, 2, and 4 g of oral Ca, respectively). Twenty-four hours after apheresis, serum tCa and iCa levels were higher, and iPTH levels lower, in donors who received oral Ca rather than placebo. Marked increases in urinary Ca and magnesium (Mg) excretion occurred at the completion of apheresis, were unaffected by Ca dose, and returned to baseline within 24 hours. Plateletpheresis also induced significant changes in serum alkaline phosphatase, 1,25-dihydroxyvitamin D, and osteocalcin levels immediately and at 24 hours after apheresis. CONCLUSION: Plateletpheresis induces marked acute metabolic effects, with sustained changes evident up to 24 hours after the completion of apheresis. Oral Ca supplementation exerts a significant but clinically modest impact on selected laboratory variables associated with these effects. Further studies are indicated to examine the long-term impact of plateletpheresis, with or without Ca supplementation, on donor Ca balance and bone density. C1 NIH, Dept Transfus Med, Dept Lab Med, Bethesda, MD 20892 USA. NIH, Biostat Serv, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Bolan, CD (reprint author), NIH, Dept Transfus Med, Dept Lab Med, Bldg 10,Rm 1C711,MSC 1184, Bethesda, MD 20892 USA. NR 23 TC 23 Z9 24 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD OCT PY 2003 VL 43 IS 10 BP 1414 EP 1422 DI 10.1046/j.1537-2995.2003.00513.x PG 9 WC Hematology SC Hematology GA 726NY UT WOS:000185606800012 PM 14507273 ER PT J AU Bakaltcheva, I Reid, T AF Bakaltcheva, I Reid, T TI Effects of blood product storage protectants on blood coagulation SO TRANSFUSION MEDICINE REVIEWS LA English DT Review ID BUTYLATED HYDROXYTOLUENE; PLASMA SUBSTITUTES; VITAMIN-E; IN-VITRO; PLATELET-AGGREGATION; WHOLE-BLOOD; L-CARNITINE; RED-CELLS; ALBUMIN; CRYOPRESERVATION AB The ever-increasing demand for blood products challenges scientists to develop new and more effective techniques for their preservation. The progress of these novel preservation technologies uses a wide variety of cryoprotectant, lyoprotectant, and other preservatives, which will need to be explored and assessed for their biological effects during blood product formulation. The leading factor in protectant selection is for their ability to provide superior preservation for a particular blood product. We believe that such protectants used in blood product development should also be evaluated for their ability to preserve normal hemostasic mechanisms. In this review, high-molecular-weight cryoprotectants, lyoprotectants, polyols, amino acids, antioxidants, and surfactants, used because of their protective properties, were evaluated for their possible role in relation to their effect on normal hemostatic mechanisms. (C) 2003 Elsevier Inc. All rights reserved. C1 Walter Reed Army Inst Res, Blood Res, Silver Spring, MD 20910 USA. RP Bakaltcheva, I (reprint author), Walter Reed Army Inst Res, Blood Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 53 TC 3 Z9 3 U1 0 U2 4 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0887-7963 J9 TRANSFUS MED REV JI Transf. Med. Rev. PD OCT PY 2003 VL 17 IS 4 BP 263 EP 271 DI 10.1053/S0887-7963(03)00040-3 PG 9 WC Hematology SC Hematology GA 737AQ UT WOS:000186206600003 PM 14571394 ER PT J AU Murray, CK Bell, D Gasser, RA Wongsrichanalai, C AF Murray, CK Bell, D Gasser, RA Wongsrichanalai, C TI Rapid diagnostic testing for malaria SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE malaria; diagnosis; rapid test ID PLASMODIUM-FALCIPARUM MALARIA; POLYMERASE CHAIN-REACTION; ANTIGEN-DETECTION TESTS; EXPERT MICROSCOPY; IMPORTED MALARIA; IMMUNOCHROMATOGRAPHIC TEST; DIPSTICK TEST; REFERENCE LABORATORIES; ASYMPTOMATIC MALARIA; RHEUMATOID-FACTOR AB Malaria rapid diagnostic devices (MRDD) have been developed with the hope that they would offer accurate, reliable, rapid, cheap and easily available alternatives to traditional methods of malaria diagnosis. The results from early malaria rapid diagnostic studies were quite promising, especially for detecting Plasmodium falciparum at densities of more than 100-500 parasites/mul. Despite the introduction of these devices over a decade ago, only a few target antigens have been introduced. Of greater concern, these devices have shown limitations in sensitivity, ability to differentiate species and robustness under field conditions in the tropics. Recent trials have revealed wide variability in sensitivity both within and between products. We review the recent trials assessing MRDD use for the diagnosis of P. falciparum and non- P. falciparum infections in endemic and non- endemic countries and describe the various aspects of these devices which need further improvement. High quality, accurate, rapid and affordable diagnostic tools are urgently needed now that new antimalarial regimens, characterized by higher cost and increased toxicity, have been introduced more widely in response to emerging multi-drug resistance. C1 Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. WHO, WPRO, MVP, Manila, Philippines. Walter Reed Army Inst Res, Silver Spring, MD USA. USN, Med Res Unit 2, Parasit Dis Program, Jakarta, Indonesia. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 57 TC 88 Z9 90 U1 1 U2 7 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD OCT PY 2003 VL 8 IS 10 BP 876 EP 883 DI 10.1046/j.1365-3156.2003.01115.x PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 727BD UT WOS:000185635400005 PM 14516298 ER PT J AU Whitehead, SS Hanley, KA Blaney, JE Gilmore, LE Elkins, WR Murphy, BR AF Whitehead, SS Hanley, KA Blaney, JE Gilmore, LE Elkins, WR Murphy, BR TI Substitution of the structural genes of dengue virus type 4 with those of type 2 results in chimeric vaccine candidates which are attenuated for mosquitoes, mice, and rhesus monkeys SO VACCINE LA English DT Article DE dengue; chimerization; vaccination ID TICK-BORNE ENCEPHALITIS; HUMAN LIVER-CELLS; NONHUMAN-PRIMATES; NONCODING REGION; FEVER; IMMUNOGENICITY; CONSTRUCTION; NEUROVIRULENCE; PROTEIN; RNA AB Antigenic chimeric viruses in which the structural genes of dengue virus type 4 (DEN4) have been replaced with those derived from dengue virus type 2 (DEN2) have been created and evaluated as a first step in generating a live attenuated tetravalent dengue virus vaccine. Specifically, the capsid, membrane precursor, and envelope (CME) or the membrane precursor and envelope (ME) gene regions of DEN2 were substituted for the corresponding genes of wild-type rDEN4 or vaccine candidate rDEN4Delta30 which contains a 30 nucleotide deletion in the 3' untranslated region. The two DEN2/4 chimeric viruses lacking the Delta30 mutation were highly attenuated in tumor-bearing SCID-HuH-7 mice, mosquitoes, and rhesus monkeys, indicating chimerization with either the CME or ME regions lead to attenuation. In mosquitoes and SCID-HuH-7 mice, addition of the Delta30 mutation to the chimeric viruses resulted in comparable or only slightly increased levels of attenuation. In rhesus monkeys, addition of the Delta30 mutation rendered the CME chimeric virus non-infectious, indicating that the attenuation resulting from chimerization and the Delta30 mutation were additive for these animals. In contrast, the attenuation in rhesus monkeys of ME chimeric virus was not significantly modified by the addition of the Delta30 mutation. The satisfactory level of attenuation and immunogenicity achieved by the ME containing DEN2/4Delta30 chimeric virus, as well as its very low infectivity for mosquitoes, make it a vaccine candidate suitable for evaluation in phase I clinical trials. Published by Elsevier Ltd. C1 NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20955 USA. RP Whitehead, SS (reprint author), NIAID, Infect Dis Lab, NIH, Room 6515,Bldg 50,50 South Dr, Bethesda, MD 20892 USA. NR 41 TC 69 Z9 73 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 1 PY 2003 VL 21 IS 27-30 BP 4307 EP 4316 DI 10.1016/S0264-410X(03)00488-2 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 747XF UT WOS:000186830800029 PM 14505913 ER PT J AU Hoffman, K Costello, C Menich, M Grabenstein, JD Engler, RJM AF Hoffman, K Costello, C Menich, M Grabenstein, JD Engler, RJM TI Using a structured medical note for determining the safety profile of anthrax vaccine for US soldiers in Korea SO VACCINE LA English DT Article DE anthrax vaccine; vaccine safety profile; adverse event reporting; cohort study; structured medical note; outcome analysis ID ADVERSE EVENTS; ALUMINUM; HUMANS; SURVEILLANCE; PERSPECTIVE; ROUTE; NEEDS AB Selected military personnel are immunized with an FDA-licensed anthrax vaccine unless there are clinical contraindications. The objective of this analysis is to capture the experience of soldiers receiving anthrax vaccine to assist in better patient-provider communication and clarify the safety profile of the vaccine in this population as a quality-assurance initiative. Between August 1998 and July 1999, 2824 soldiers immunized against anthrax at one military clinic completed a structured medical note that was reviewed by a clinician. Female gender, prior vaccine-associated adverse events, and medication use were significantly related to higher reports of adverse events. All reported immediate consequences resolved. (C) 2003 Elsevier Ltd. All rights reserved. C1 Mil & Vet Hlth Coordinating Board, Washington, DC 20420 USA. Darnall Army Community Hosp, Dept Family Practice, Ft Hood, TX USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USA, Med Command, Falls Church, VA USA. Walter Reed Army Med Ctr, Walter Reed Natl Vaccine Healthcare Ctr, Allergy Immunol Dept, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Hoffman, K (reprint author), Mil & Vet Hlth Coordinating Board, Washington, DC 20420 USA. NR 38 TC 14 Z9 15 U1 1 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD OCT 1 PY 2003 VL 21 IS 27-30 BP 4399 EP 4409 DI 10.1016/S0264-410X(03)00435-3 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 747XF UT WOS:000186830800039 PM 14505923 ER PT J AU Oh, SY Chiu, PC Kim, BJ Cha, DK AF Oh, SY Chiu, PC Kim, BJ Cha, DK TI Enhancing Fenton oxidation of TNT and RDX through pretreatment with zero-valent iron SO WATER RESEARCH LA English DT Article DE 2,4,6-trinitrotoluene; hexahydro-1,3,5-trinitro-1,3,5-triazine; zero-valent iron; Fenton oxidation ID SYNTHETIC WASTE-WATER; ANAEROBIC SLUDGE; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; PHOTOCATALYTIC DEGRADATION; 2,4,6-TRINITROTOLUENE TNT; ORGANIC-COMPOUNDS; REACTIVE BARRIER; ACTIVATED CARBON; AQUEOUS-SOLUTION; ZEROVALENT IRON AB The effect of reductive treatment with elemental iron on the rate and extent of TOC removal by Fenton oxidation was studied for the explosives 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) using a completely stirred tank reactor (CSTR). The results support the hypothesis that TNT and RDX are reduced with elemental iron to products that are oxidized more rapidly and completely by Fenton's reagent. Iron pretreatment enhanced the extent of total organic carbon (TOC) removal by approximately 20% and 60% for TNT and RDX, respectively. Complete TOC removal was achieved for TNT and RDX solutions with iron pretreatment under optimal conditions. On the other hand, without iron pretreatment, complete TOC removal of TNT and RDX solutions was not achieved even with much higher H2O2 and Fe2+ concentrations. Nitrogen was recovered as NH4+ and NO3- when Fe(0)-treated TNT and RDX solutions were subjected to Fenton oxidation. The bench-scale iron treatment-Fenton oxidation integrated system showed more than 95% TOC removal for TNT and RDX solutions under optimal conditions. These results suggest that the reduction products of TNT and RDX are more rapidly and completely degraded by Fenton oxidation and that a sequential iron treatment-Fenton oxidation process may be a viable technology for pink water treatment. (C) 2003 Elsevier Ltd. All rights reserved. C1 Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. USA, Ctr Res Dev & Engn, Champaign, IL 61826 USA. RP Cha, DK (reprint author), Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. NR 51 TC 71 Z9 76 U1 2 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD OCT PY 2003 VL 37 IS 17 BP 4275 EP 4283 DI 10.1016/S0043-1354(03)00343-9 PG 9 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 720KU UT WOS:000185260600025 PM 12946911 ER PT J AU Sipos, ML Sweeney, RE AF Sipos, ML Sweeney, RE TI Behavioral data management using VISUAL BASIC FOR APPLICATIONS to automate data capture and analysis SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE data entry; data management; automation; VISUAL BASIC FOR APPLICATIONS; macros; Microsoft Excel AB Many researchers are familiar with the spreadsheet capabilities of Microsoft Excel(R), but have never explored using customized VISUAL BASIC FOR APPLICATIONS (VBA) macros embedded in the program. At the United States Army Medical Research Institute of Chemical Defense (USAMRICD), the implementation of VBA program code to carry out repetitive operations has resulted in a tremendous savings in both the time and manpower required to reliably capture, analyze, and plot data from research protocols. A set of "template" workbooks was developed and is used to organize data from different types of studies. At the heart of the concept is a "setup information" worksheet onto which the user enters information about the study (i.e. the number of subjects, groups, graphs). Clicking a control button on this worksheet launches the VBA code that creates worksheets for each subject, group and chart specified. A "pairmatch" function allows the user to create groups either randomly or by pair matching based on user-specified variables. Controls are provided that run VBA program code to parse subject data files into the proper worksheets and perform group averages. Charts are updated automatically whenever group averages change so that the researcher always has an up-to-date plot available. The ability to reformat the captured data onto a "statistical output" worksheet allows data to be imported easily to statistical software packages. The concept is being used for several different types of studies at USAMRICD and has significantly reduced not only amount of time spent on data management, but also the number of data entry errors. Readers interested in acquiring an electronic copy of the startle workbook example, which contains the complete VBA code, should send the request to the authors at reseco@erols.com or maurice.sipos@us.army.mil. (C) 2003 Elsevier B.V. All rights reserved. C1 USA, Med Res Inst Chem Def, Drug Assessment Div, Adv Assessment Branch, Aberdeen Proving Ground, MD 21010 USA. RESECO Res Engn Consultants, Upper Darby, PA 19082 USA. RP Sipos, ML (reprint author), USA, War Coll, Army Phys Fitness Res Inst, 122 Forbes Ave, Carlisle, PA 17013 USA. NR 2 TC 0 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 J9 J NEUROSCI METH JI J. Neurosci. Methods PD SEP 30 PY 2003 VL 128 IS 1-2 BP 53 EP 65 DI 10.1016/S0165-0270(03)00150-X PG 13 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 721GD UT WOS:000185307900006 PM 12948548 ER PT J AU King, JS Neff, CW Summers, CJ Park, W Blomquist, S Forsythe, E Morton, D AF King, JS Neff, CW Summers, CJ Park, W Blomquist, S Forsythe, E Morton, D TI High-filling-fraction inverted ZnS opals fabricated by atomic layer deposition SO APPLIED PHYSICS LETTERS LA English DT Article ID PHOTONIC CRYSTALS; BANDGAP; SYSTEMS; SPHERES; GROWTH AB The infiltration of three-dimensional opal structures has been investigated by atomic layer deposition. Demonstrations using ZnS:Mn show that filling fractions >95% can be achieved and that the infiltrated material is of high-quality crystalline material as assessed by photoluminescence measurements. These results demonstrate a flexible and practical pathway to attaining high-performance photonic crystal structures and optical microcavities. (C) 2003 American Institute of Physics. C1 Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. Univ Colorado, Dept Elect & Comp Engn, Boulder, CO 80309 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP King, JS (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. NR 21 TC 70 Z9 71 U1 3 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 29 PY 2003 VL 83 IS 13 BP 2566 EP 2568 DI 10.1063/1.1609240 PG 3 WC Physics, Applied SC Physics GA 725AX UT WOS:000185521400022 ER PT J AU Watanaveeradej, V DeSouza, MS Benenson, MW Sirisopana, N Nitayaphan, S Chanbancherd, P Brown, AE Sanders-Buell, E Birx, DL McCutchan, FE Carr, JK AF Watanaveeradej, V DeSouza, MS Benenson, MW Sirisopana, N Nitayaphan, S Chanbancherd, P Brown, AE Sanders-Buell, E Birx, DL McCutchan, FE Carr, JK TI Subtype C/CRF01 _AE recombinant HIV-1 found in Thailand SO AIDS LA English DT Article ID DRUG-USERS; BANGKOK; TYPE-1 AB The first HIV-1 recombinant between CRF0I_A.E and subtype C, NP1809, has been identified in Thailand. The nearly full genome was polymerase chain reaction amplified, sequenced and phylogenetically analysed. NP1809 was a complex recombinant, with at least 15 breakpoints. Gag and gp120 were subtype C, whereas pol and intracellular gp41 were CRF01_AE. We report a new inter-subtype recombinant of CRF01_AE and subtype C, establishing for the first time the presence of subtype C genetic material in Thailand. C1 Phramongkutklao Hosp, Bangkok, Thailand. M Jackson Fdn, Bangkok, Thailand. Armed Forces Res Inst Med Sci, Bangkok, Thailand. Army Inst Pathol, Bangkok, Thailand. Walter Reed Army Inst Res, Rockville, MD USA. RP Watanaveeradej, V (reprint author), Phramongkutklao Hosp, Bangkok, Thailand. NR 11 TC 11 Z9 12 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD SEP 26 PY 2003 VL 17 IS 14 BP 2138 EP 2140 DI 10.1097/01.aids.0000088167.01779.e5 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 733NV UT WOS:000186008300022 PM 14502024 ER PT J AU O'Malley, PG Taylor, AJ AF O'Malley, PG Taylor, AJ TI Screening for coronary calcification - Reply SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter ID TOMOGRAPHY C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP O'Malley, PG (reprint author), Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD SEP 24 PY 2003 VL 290 IS 12 BP 1577 EP 1577 DI 10.1001/jama.290.12.1577-a PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 723ZK UT WOS:000185461300012 ER PT J AU Thiyagarajan, M Samuelson, LA Kumar, J Cholli, AL AF Thiyagarajan, M Samuelson, LA Kumar, J Cholli, AL TI Helical conformational specificity of enzymatically synthesized water-soluble conducting polyaniline nanocomposites SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID POLYMERIZATION; TEMPLATE; ACID C1 Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. USA, Natick Soldier Ctr, Soldier & Biol Chem Command, Natick, MA 01760 USA. RP Cholli, AL (reprint author), Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. NR 16 TC 101 Z9 106 U1 1 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD SEP 24 PY 2003 VL 125 IS 38 BP 11502 EP 11503 DI 10.1021/ja035414h PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA 728HE UT WOS:000185711100024 PM 13129345 ER PT J AU Videen, G AF Videen, G TI Polarized infrared emissivity from dew droplets on a surface SO APPLIED OPTICS LA English DT Article AB We model the infrared polarization emissivity from spherical particles on a plane surface. The emissivity and polarization is primarily a function of the density of particles multiplied by their cross-sectional area. The presence of particles tends to reduce the polarization. As the emission angle increases from near-normal incidence, the polarization tends to pass through a maximum, followed by a minimum and a final sharp rise at near grazing angles. The mechanism for this structure is the shadowing of different portions of the spherical particles by other particles. (C) 2003 Optical Society of America. C1 USA, Res Lab, AMSRL, IS,EE, Adelphi, MD 20783 USA. RP Videen, G (reprint author), USA, Res Lab, AMSRL, IS,EE, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gvideen@arl.army.mil NR 7 TC 2 Z9 2 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD SEP 20 PY 2003 VL 42 IS 27 BP 5557 EP 5560 DI 10.1364/AO.42.005557 PG 4 WC Optics SC Optics GA 722BL UT WOS:000185354800025 PM 14526846 ER PT J AU Yi, HM Wu, LQ Sumner, JJ Gillespie, JB Payne, GF Bentley, WE AF Yi, HM Wu, LQ Sumner, JJ Gillespie, JB Payne, GF Bentley, WE TI Chitosan scaffolds for biomolecular assembly: Coupling nucleic acid probes for detecting hybridization SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE chitosan; glutaralclehyde; single-strand DNA; hybridization ID POLYSACCHARIDE CHITOSAN; MODIFIED ELECTRODE; DNA; BIOSENSOR; MICROARRAY; CONJUGATION AB Chitosan, a naturally occurring biopolymer, was used as a scaffold for the covalent binding of single-stranded DNA oligonucleotide probes in a fluorescence-based nucleic acid hybridization assay. Chitosan's pH dependent chemical and electrostatic properties enable its deposition on electrodes and metal surfaces, as well as on the bottom of microtiter plates. A combinatorial 96-well microtiter plate format was used to optimize chemistries and reaction conditions leading to hybridization experiments. We found the coupling of oligonucleotides using relatively common glutaraldehyde chemistry was quite robust. Our hybridization results for complementary ssDNA oligonucleotides (E. coli dnaK sequences) demonstrated linear fluorescence intensity with concentration of E. coli dnaK-specific oligonucleotide from 0.73 muM to 6.6 muM. Moreover, hybridization assays were specific as there was minimal fluorescence associated with noncomplementary groEL oligonucleotide. Finally, these results demonstrate the portability of a DNA hybridization assay based on covalent coupling to chitosan, which, in turn, can be deposited onto various surfaces. More arduous surface preparation techniques involving silanizing agents and hazardous washing reagents are eliminated using this technique. (C) 2003 Wiley Periodicals, Inc. C1 Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA. Univ Maryland, Dept Chem Engn, College Pk, MD 20742 USA. Univ Maryland Baltimore Cty, Dept Chem & Biochem Engn, Baltimore, MD 21228 USA. USA, Res Lab, Adelphi, MD USA. RP Bentley, WE (reprint author), Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, 5115 Plant Sci Bldg, College Pk, MD 20742 USA. RI Yi, Hyunmin/B-9852-2008 NR 19 TC 26 Z9 27 U1 2 U2 12 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0006-3592 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD SEP 20 PY 2003 VL 83 IS 6 BP 646 EP 652 DI 10.1002/bit.10712 PG 7 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 708AQ UT WOS:000184544500003 PM 12889029 ER PT J AU Hoover, JJ AF Hoover, JJ TI Keeping out unwanted fish SO SCIENCE LA English DT Letter C1 ERDC WES EE A, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Hoover, JJ (reprint author), ERDC WES EE A, Waterways Expt Stn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM hooverj@wes.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD SEP 19 PY 2003 VL 301 IS 5640 BP 1671 EP 1671 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 722QN UT WOS:000185387700020 PM 14500961 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determinations of Pb6O(OH)(6)(4+) SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; lead ions ID COMPACT EFFECTIVE POTENTIALS; EXPONENT BASIS-SETS; CRYSTAL-STRUCTURE; AQUEOUS-SOLUTIONS; LEAD; SOLUBILITY; EFFICIENT; COMPLEXES; CLUSTERS; SPECTRA AB The vibrational frequencies and corresponding normal mode assignments of Pb6O(OH)(6)(4+) are examined theoretically using the GAUSSIAN98 set of quantum chemistry codes and compared against available experimental data. All normal modes were successfully assigned to one of four types of motion predicted by a group theoretical analysis (Pb-O stretch, O-H stretch, O-H wag, and Pb-O-Pb bend) utilizing the C-2v symmetry of the molecule. The molecular orbitals of Pb-4(OH)(4)(4+) are examined. Published by Elsevier B.V. C1 US Army Edgewood Chem & Biol Ctr, AMSSB RRT DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), US Army Edgewood Chem & Biol Ctr, AMSSB RRT DP, Aberdeen Proving Ground, MD 21010 USA. NR 31 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD SEP 18 PY 2003 VL 635 BP 11 EP 24 DI 10.1016/S0166-1280(03)00378-6 PG 14 WC Chemistry, Physical SC Chemistry GA 720QF UT WOS:000185270900002 ER PT J AU Jensen, JO AF Jensen, JO TI Quantum chemical analysis of the vibrational frequencies and structure of tetrachlorodiborane SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; boron chloride; diboron tetra chloride; tetrachlorodiborane ID DIBORON TETRACHLORIDE; INTERNAL ROTATION; MOLECULAR POLARIZABILITIES; POLYATOMIC-MOLECULES; INFRARED-SPECTRA; BORON-COMPOUNDS; AB-INITIO; B2CL4; CHLORINE; CL AB The normal mode frequencies and corresponding vibrational assignments of B2Cl4 are examined theoretically using the GAUSSIAN98 set of quantum chemistry codes. All normal modes were successfully assigned to one of six types of motion predicted by a group theoretical analysis (B-B stretch, B-Cl stretch, BCl2 scissors, BCl2 rock, BCl2 wag, and B-B torsion) utilizing the D-2d symmetry of the molecule. The vibrational modes of the naturally isotopically substituted (1-B-10 and 2-B-10) forms of B2Cl4 were also calculated and compared against experimental data. The barrier to rotation of the around the B-B bond is examined. Molecular orbitals are presented. Published by Elsevier B.V. C1 USA, Army Edgewood Chem & Biol Ctr, AMSSB RRT DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Army Edgewood Chem & Biol Ctr, AMSSB RRT DP, Aberdeen Proving Ground, MD 21010 USA. NR 65 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD SEP 18 PY 2003 VL 635 BP 211 EP 219 DI 10.1016/S0166-1280(03)00458-5 PG 9 WC Chemistry, Physical SC Chemistry GA 720QF UT WOS:000185270900020 ER PT J AU Moron, JA Zakharova, I Ferrer, JV Merrill, GA Hope, B Lafer, EM Lin, ZC Wang, JB Javitch, JA Galli, A Shippenberg, TS AF Moron, JA Zakharova, I Ferrer, JV Merrill, GA Hope, B Lafer, EM Lin, ZC Wang, JB Javitch, JA Galli, A Shippenberg, TS TI Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity SO JOURNAL OF NEUROSCIENCE LA English DT Article DE dopamine transporter; trafficking; epitope-tagged-hDAT; HEK 293 cells; MAPK; biotinylation ID HUMAN NOREPINEPHRINE TRANSPORTER; MAP KINASE; SEROTONIN TRANSPORTERS; IN-VIVO; STRIATAL SYNAPTOSOMES; FUNCTIONAL REGULATION; TYROSINE KINASES; PHORBOL ESTERS; CELL-LINES; PHOSPHORYLATION AB The dopamine transporter (DAT) regulates the clearance of dopamine (DA) released into the extracellular space and is an important site on which psychostimulants act to produce their effects. Here, we show that mitogen-activated protein kinase (MAPK) regulates the transport capacity and intracellular trafficking of DAT. Incubation of striatal synaptosomes or epitope-tagged human DAT (hDAT) human embryonic kidney (HEK) 293 cells with the MAPK kinase (MEK) inhibitors 1,4-diamino-2,3-dicyano-1,4-bis(omicron-aminophenylmercapto) butadiene and 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one decreased DA uptake in a concentration- and time-dependent manner. Kinetic studies revealed a decrease in the capacity of transport (V-max) but no change in K-m. Immunoblotting confirmed labeling of p42 and p44 MAPK in untreated striatal synaptosomes and HEK 293 cells, consistent with constitutive MAPK activation, and the inhibitors used decreased MAPK phosphorylation. Biotinylation and confocal imaging studies showed that MAPK inhibition promoted the clathrin-associated redistribution of hDAT from the plasma membrane to the cytosol. In contrast, transient transfection of hDAT-expressing cells with constitutively active MEK increased the V-max of DA transport without altering K-m. However, only a small increase in hDAT cell surface expression was seen. These data demonstrate an involvement of the MAPK cascade in regulating DAT transport capacity in striatum and that inhibition of this cascade decreases DAT cell surface expression in HEK 293 cells. Furthermore, they highlight the potential role of MAPK as a presynaptic mechanism that regulates DA signaling. C1 NIDA, Integrat Neurosci Sect, Intramural Res Program, Behav Neurosci Branch, Baltimore, MD 21224 USA. NIDA, Integrat Neurosci Sect, Intramural Res Program, Mol Neurobiol Branch, Baltimore, MD 21224 USA. Columbia Univ Coll Phys & Surg, Ctr Mol Recognit, New York, NY 10032 USA. Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, Dept Biochem, San Antonio, TX 78229 USA. Univ Texas, Hlth Sci Ctr, Dept Pharmacol, San Antonio, TX 78229 USA. Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA. RP Shippenberg, TS (reprint author), NIDA, Integrat Neurosci Sect, Intramural Res Program, Behav Neurosci Branch, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA. RI Hope, Bruce/A-9223-2010 OI Hope, Bruce/0000-0001-5804-7061 FU NIDA NIH HHS [DA11495, DA14684]; NIMH NIH HHS [MH57324]; NINDS NIH HHS [R01 NS029051] NR 66 TC 132 Z9 138 U1 2 U2 6 PU SOC NEUROSCIENCE PI WASHINGTON PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA SN 0270-6474 J9 J NEUROSCI JI J. Neurosci. PD SEP 17 PY 2003 VL 23 IS 24 BP 8480 EP 8488 PG 9 WC Neurosciences SC Neurosciences & Neurology GA 723VU UT WOS:000185452900007 PM 13679416 ER PT J AU D'Amico, AV Moul, JW Carroll, PR Sun, L Lubeck, D Chen, MH AF D'Amico, AV Moul, JW Carroll, PR Sun, L Lubeck, D Chen, MH TI Surrogate end point for prostate cancer-specific mortality after radical prostatectomy or radiation therapy SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Article ID ANTIGEN RECURRENCE; DISEASE RECURRENCE; CAPSURE DATABASE; CLINICAL-TRIALS; PROGRESSION; SURVIVAL; FAILURE; VALIDATION; NOMOGRAM; CRITERIA AB Background: The relationship between prostate-specific antigen (PSA)-defined recurrence and prostate cancer-specific mortality remains unclear. Therefore, we evaluated the hypothesis that a short post-treatment PSA doubling time (PSA-DT) after radiation therapy is a surrogate end point for prostate cancer-specific mortality by analyzing two multi-institutional databases. Methods: Baseline, treatment, and follow-up information was compiled on a cohort of 8669 patients with prostate cancer treated with surgery (5918 men) or radiation (2751 men) from January 1, 1988, through January 1, 2002, for localized or locally advanced, nonmetastatic prostate cancer. We used a Cox regression analysis to test whether the post-treatment PSA-DT was a prognostic factor that was independent of treatment received. All statistical tests were two-sided. Results: The post-treatment PSA-DT was statistically significantly associated with time to prostate cancer-specific mortality and with time to all-cause mortality (all P-Cox<001). However, the treatment received was not statistically significantly associated with time to prostate cancer-specific mortality after PSA-defined disease recurrence for patients with a PSA-DT of less than 3 months (P-Cox =.90) and for patients with a PSA-DT of 3 months or more (P-Cox =.28) when controlling for the specific value of the PSA-DT. Furthermore, after a PSA-defined recurrence, a PSA-DT of less than 3 months was statistically significantly associated with time to prostate cancer-specific mortality (median time = 6 years; hazard ratio = 19.6, 95 % confidence interval = 12.5 to 30.9). Conclusion: A post-treatment PSA-DT of less than 3 months and the specific value of the posttreatment PSA-DT when it is 3 months or more appear to be surrogate end points for prostate cancer-specific mortality after surgery or radiation therapy. We recommend that consideration be given to initiating androgen suppression therapy at the time of a PSA-defined recurrence when the PSA-DT is less than 3 months to delay the imminent onset of metastatic bone disease. C1 Brigham & Womens Hosp, Dept Radiat Oncol, Boston, MA 02115 USA. Dana Farber Canc Inst, Boston, MA 02115 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Urol Serv, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Bethesda, MD USA. Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA. Univ Connecticut, Dept Stat, Storrs, CT 06269 USA. RP D'Amico, AV (reprint author), Brigham & Womens Hosp, Dept Radiat Oncol, 75 Francis St,L-2 Level, Boston, MA 02115 USA. NR 37 TC 338 Z9 344 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD SEP 17 PY 2003 VL 95 IS 18 BP 1376 EP 1383 DI 10.1093/jnci/djg043 PG 8 WC Oncology SC Oncology GA 722AV UT WOS:000185352900009 PM 13130113 ER PT J AU Jackson, WL AF Jackson, WL TI Management of acute renal failure SO ANNALS OF INTERNAL MEDICINE LA English DT Letter ID PULMONARY C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Jackson, WL (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD SEP 16 PY 2003 VL 139 IS 6 BP 529 EP 530 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 721PE UT WOS:000185324100017 PM 13679337 ER PT J AU Seehusen, DA Reeves, MM Fomin, DA AF Seehusen, DA Reeves, MM Fomin, DA TI Cerebrospinal fluid analysis SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; POLYMERASE-CHAIN-REACTION; BACTERIAL-MENINGITIS; VIRAL-INFECTIONS; DIAGNOSIS; MANAGEMENT AB Lumbar puncture is frequently performed in primary care. Properly interpreted tests can make cerebrospinal fluid (CSF) a key tool in the diagnosis of a variety of diseases. Proper evaluation of CSF depends on knowing which tests to order, normal ranges for the patient's age, and the test's limitations. Protein level, opening pressure, and CSF-to-serum glucose ratio vary with age. Xanthochromia is most often caused by the presence of blood, but several other conditions should be considered. The presence of blood can be a reliable predictor of subarachnoid hemorrhage but takes several hours to develop. The three-tube method, commonly used to rule out a central nervous system hemorrhage after a "traumatic tap," is not completely reliable. Red blood cells in CSF caused by a traumatic tap or a subarachnoid hemorrhage artificially increase the white blood cell count and protein level, thereby confounding the diagnosis. Diagnostic uncertainty can be decreased by using accepted corrective formulas. White blood cell differential may be misleading early in the course of meningitis, because more than 10 percent of cases with bacterial infection will have an initial lymphocytic predominance and viral meningitis may initially be dominated by neutrophils. Culture is the gold standard for determining the causative organism in meningitis. However, polymerase chain reaction is much faster and more sensitive in some circumstances. Latex agglutination, with high sensitivity but low specificity, may have a role in managing partially treated meningitis. To prove herpetic, cryptococcal, or tubercular infection, special staining techniques or collection methods may be required. Copyright(C) 2003 American Academy of Family Physicians. C1 Tripler Army Med Ctr, Dept Family Practice & Emergency Med Serv, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. RP Seehusen, DA (reprint author), 5803 152nd Ave Ct E, Sumner, WA 98390 USA. NR 25 TC 75 Z9 79 U1 0 U2 7 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD SEP 15 PY 2003 VL 68 IS 6 BP 1103 EP 1108 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 723BZ UT WOS:000185413700007 PM 14524396 ER PT J AU Szeinbach, SL Baron, M Guschke, T Torkilson, EA AF Szeinbach, SL Baron, M Guschke, T Torkilson, EA TI Survey of state requirements for unit-of-use packaging SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Article ID SHORTAGE C1 Ohio State Univ, Coll Pharm, Dept Pharm Practice & Adm, Columbus, OH 43210 USA. Univ So Calif, Sch Pharm, Dept Clin Pharm, Los Angeles, CA USA. KEOGH Consulting, Integrated Supply chain Solut, Palm Beach Gardens, FL USA. USA, Med Dept Act, Ft Carson, CO USA. RP Szeinbach, SL (reprint author), Ohio State Univ, Coll Pharm, Dept Pharm Practice & Adm, 500 W 12th Ave, Columbus, OH 43210 USA. NR 26 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD SEP 15 PY 2003 VL 60 IS 18 BP 1863 EP 1866 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 724ZT UT WOS:000185518700011 PM 14521038 ER PT J AU Salcedo, R Zhang, X Young, HA Michael, N Wasserman, K Ma, WH Martins-Green, M Murphy, WJ Oppenheim, JJ AF Salcedo, R Zhang, X Young, HA Michael, N Wasserman, K Ma, WH Martins-Green, M Murphy, WJ Oppenheim, JJ TI Angiogenic effects of prostaglandin E-2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells SO BLOOD LA English DT Article ID CHEMOKINE RECEPTOR CXCR4; CAPILLARY-TUBE FORMATION; PROTEIN-KINASE-C; GROWTH-FACTOR; PROSTACYCLIN PRODUCTION; RHEUMATOID-ARTHRITIS; ARACHIDONIC-ACID; IN-VIVO; FUNCTIONAL EXPRESSION; TUMOR PROGRESSION AB Stimulation of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) increases the expression of CXCR4 on endothelial cells, rendering these cells more responsive to stromal-derived factor 1 (SDF-1), an anglogenic CXC chemokine and unique ligand for CXCR4. Here, we show that prostaglandin E-2 (PGE(2)) mediates the effects of bFGF and VEGF in up-regulating CXCR4 expression on human microvascular endothelial cells (HMECs). Forskolin or 3-isobutyl-1-methyl xanthine (IBMX), 2 inducers of adenylate cyclase, markedly enhanced, whereas cyclooxygenase (COX) inhibitors including aspirin, piroxicam, and NS398 markedly inhibited CXCR4 expression on HMECs. Furthermore, the ability of PGE2 to augment in vitro tubular formation in SDF-1alpha containing matrigel was inhibited completely by blocking CXCR4. Treatment of bFGF- or VEGF-stimulated HMECs with COX inhibitors blocked tubular formation by about 50% to 70%. Prostaglandin-induced human endothelial cell organization and subsequent vascularization can be inhibited to a greater extent by a neutralizing antibody to human CXCR4 in severe combined immunodeficient mice. Additionally, VEGF- and bFGF-induced angiogenesis in vivo was also inhibited by about 50% by NS-398 or piroxicam, and this inhibitory effect was accompanied by decreased expression of CXCR4 on murine endothelial cells. Consequently, by inducing CXCR4 expression, prostaglandin accounts for about 50% of the tubular formation in vitro and in vivo angiogenic effects of VEGF and bFGF. Moreover, augmentation of CXCR4 expression by VEGF, bFGF, and PGE2 involves stimulation of transcription factors binding to the Sp1-binding sites within the promoter region of the CXCR4 gene. These findings indicate that PGE2 is a mediator of VEGF- and bFGF-induced CXCR4-dependent neovessel assembly in vivo and show that anglogenic effects of PGE2 require CXCR4 expression. C1 NCI, Mol Immunoregulat Lab, Expt Immunol Lab,Intramural Res Support Program, Ctr Canc Res,SAIC, Frederick, MD 21702 USA. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. Univ Calif Riverside, Dept Cell Biol & Neurosci, Riverside, CA 92521 USA. RP Salcedo, R (reprint author), NCI, Mol Immunoregulat Lab, Expt Immunol Lab,Intramural Res Support Program, Ctr Canc Res,SAIC, Bldg 567,Rm 210, Frederick, MD 21702 USA. RI Zhang, Xia/B-8152-2008 OI Zhang, Xia/0000-0002-9040-1486 FU NCI NIH HHS [N01 CO 12400] NR 76 TC 110 Z9 114 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD SEP 15 PY 2003 VL 102 IS 6 BP 1966 EP 1977 DI 10.1182/blood-2002-11-3400 PG 12 WC Hematology SC Hematology GA 721NQ UT WOS:000185322800015 PM 12791666 ER PT J AU Pfeiffer, R McShane, L Wargovich, M Burt, R Kikendall, W Lawson, M Lanza, E Schatzkin, A AF Pfeiffer, R McShane, L Wargovich, M Burt, R Kikendall, W Lawson, M Lanza, E Schatzkin, A TI The effect of a low-fat, high fiber, fruit and vegetable intervention on rectal mucosal proliferation SO CANCER LA English DT Article DE rectal mucosal cell proliferation; Polyp Prevention Trial; dietary intervention; adenoma recurrence; intermediate endpoint ID EPITHELIAL-CELL PROLIFERATION; RANDOMIZED CONTROLLED-TRIAL; POLYP PREVENTION TRIAL; SPORADIC ADENOMA PATIENTS; CALCIUM SUPPLEMENTATION; COLORECTAL ADENOMAS; COLON-CANCER; DAIRY FOODS; HIGH-RISK; DIFFERENTIATION AB BACKGROUND. Because studies of diet and colorectal carcinoma tend to be large and complex, researchers have long been interested in the investigation of dietary exposures in relation to putative intermediate markers of large bowel malignancy, such as colorectal epithelial cell proliferation. The basic hypothesis underlying these investigations is that specific dietary components may reduce or increase the rate of cell proliferation, which, in turn, may reduce or increase neoplastic changes in the large bowel. METHODS. The authors assessed the effects of a 4-year, low-fat, high-fiber, fruit and vegetable-enriched dietary intervention on colorectal epithelial cell proliferation among 399 participants from the Polyp Prevention Trial, a randomized multicenter trial with adenoma recurrence as the primary endpoint. Rectal biopsies were taken from flat, normal appearing mucosa on patients at baseline, after I year, and after 4 years. Two assays, bromodeoxyuridine (BrdU) and proliferating cell nuclear antigen (PCNA), were used to evaluate two summary measures of proliferation: the labeling index (LI) and the proliferative height (PH). RESULTS. There were no significant differences between changes in LI and PH over the 4-year period for the intervention and control groups. This finding parallels the finding in the larger primary study, in which the dietary intervention did not alter adenoma recurrence rates. CONCLUSIONS. A low-fat, high-fiber, fruit and vegetable-enriched dietary intervention did not alter rectal mucosal cell proliferation rates. Published 2003 by the American Cancer Society. C1 NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. NCI, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA. Univ S Carolina, Sch Med, Columbia, SC USA. Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Kaiser Permanente, Dept Med, Sacramento, CA USA. NCI, Canc Res Ctr, NIH, Bethesda, MD 20892 USA. RP Pfeiffer, R (reprint author), NCI, Div Canc Epidemiol & Genet, NIH, 6120 Execut Blvd,EPS-8030, Bethesda, MD 20892 USA. RI Pfeiffer, Ruth /F-4748-2011 NR 23 TC 6 Z9 6 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD SEP 15 PY 2003 VL 98 IS 6 BP 1161 EP 1168 DI 10.1002/cncr.11608 PG 8 WC Oncology SC Oncology GA 720TV UT WOS:000185276800007 PM 12973839 ER PT J AU Polyakov, AY Smirnov, NB Govorkov, AV Baik, KH Pearton, SJ Luo, B Ren, F Zavada, JM AF Polyakov, AY Smirnov, NB Govorkov, AV Baik, KH Pearton, SJ Luo, B Ren, F Zavada, JM TI Hydrogen plasma passivation effects on properties of p-GaN SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MG-DOPED GAN; VAPOR-PHASE EPITAXY; ELECTRON-BEAM DISSOCIATION; DEEP CENTERS; GALLIUM NITRIDE; FILMS; ACTIVATION; DIFFUSION; DEPOSITION; LAYERS AB The effects of hydrogen on the electrical and optical properties of p-GaN were investigated. Hydrogen is readily incorporated into the material at temperatures of 250-350 degreesC, which is consistent with the low activation energy for diffusion reported by Seager et al. [J. Appl. Phys. 92, 7246 (2002)] in GaN p-n junctions. From comparison with the results of earlier experiments, hydrogen diffusivity appears to be a strong function of the hydrogen concentration incorporated into the material during growth. More than an order of magnitude decrease in hole concentration was observed after the hydrogen plasma treatment and from the measurements of the temperature dependence of conductivity. This is the result of hydrogen passivation of acceptors rather than of increased compensation by donor centers. Hydrogen treatment was also shown to lead to a strong suppression of 0.3 eV and 0.6 eV traps and to a strong increase in the magnitude of the photocurrent which are the results of passivation of deep-level defects by hydrogen. At the same time, hydrogen plasma treatment led to a strong increase in the concentration of 0.4 eV hole traps. (C) 2003 American Institute of Physics. C1 Inst Rare Met, Moscow 119017, Russia. Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Polyakov, AY (reprint author), Inst Rare Met, B Tolmachevsky 5, Moscow 119017, Russia. RI Smirnov, Nickolai/K-8935-2015 OI Smirnov, Nickolai/0000-0002-4993-0175 NR 32 TC 18 Z9 19 U1 2 U2 16 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 2003 VL 94 IS 6 BP 3960 EP 3965 DI 10.1063/1.1603343 PG 6 WC Physics, Applied SC Physics GA 723EN UT WOS:000185419600040 ER PT J AU Grujicic, M Chittajallu, KM Walsh, S AF Grujicic, M Chittajallu, KM Walsh, S TI Optimization of the VARTM process for enhancement of the degree of devolatilization of polymerization by-products and solvents SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID COMPOSITES AB Devolatilization of the polymerization by-products and the impregnation solvent during Vacuum Assisted Resin Transfer Molding (VARTM) of the polyimide polymers is analyzed using a combined continuum hydrodynamics/chemical reaction one-dimensional model. The model which consists of seven coupled partial differential equations is solved using a finite element collocation method based on the method of lines. The results obtained reveal that the main process parameters which give rise to lower gas-phase contents in the VARTM-processed polymer matrix composites are the vacuum pressure and the tool-plate heating rate. Lower tool-plate heating rates are found to be beneficial since hey promote devolatilization of the impregnation solvent at lower temperatures at which the degree of polymerization and, hence, resin viscosity are low. (C) 2003 Kluwer Academic Publishers C1 Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. USA, Res Lab, WMRD AMSRL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. NR 11 TC 6 Z9 6 U1 1 U2 4 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD SEP 15 PY 2003 VL 38 IS 18 BP 3729 EP 3739 DI 10.1023/A:1025967813837 PG 11 WC Materials Science, Multidisciplinary SC Materials Science GA 726EF UT WOS:000185585000005 ER PT J AU Burgess, EB AF Burgess, EB TI Flyboys: A true story of courage. SO LIBRARY JOURNAL LA English DT Book Review C1 Comobined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), Comobined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 15 PY 2003 VL 128 IS 15 BP 68 EP 68 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 720ZV UT WOS:000185293300123 ER PT J AU Minyard, CM AF Minyard, CM TI The battle that stopped Rome: Augustus, Arminius, and the slaughter of the legions in the Teutoburg Forest. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Blountstown, FL USA. RP Minyard, CM (reprint author), USA, Blountstown, FL USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 15 PY 2003 VL 128 IS 15 BP 72 EP 72 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 720ZV UT WOS:000185293300144 ER PT J AU Bahder, TB AF Bahder, TB TI Relativity of GPS measurement SO PHYSICAL REVIEW D LA English DT Article ID CLOCK-SYNCHRONIZATION AB The relativity of Global Positioning System (GPS) pseudorange measurements is explored within the geometrical optics approximation in the curved space-time near Earth. A space-time grid for navigation is created by the discontinuities introduced in the electromagnetic field amplitude by the P-code broadcast by the GPS satellites. We compute the world function of space-time near Earth, and we use it to define a scalar phase function that describes the space-time grid. We use this scalar phase function to define the measured pseudorange, which turns out to be a two-point space-time scalar under generalized coordinate transformations. Though the measured pseudorange is an invariant, it depends on the world lines of the receiver and satellite. While two colocated receivers measure two different pseudoranges to the same satellite, they obtain the correct position and time, independent of their velocity. We relate the measured pseudorange to the geometry of space-time and find corrections to the conventional model of the pseudorange that are on the order of the gravitational radius of the Earth. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM bahder@arl.army.mil NR 36 TC 22 Z9 23 U1 0 U2 5 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0010 EI 2470-0029 J9 PHYS REV D JI Phys. Rev. D PD SEP 15 PY 2003 VL 68 IS 6 AR 063005 DI 10.1103/PhysRevD.68.063005 PG 13 WC Astronomy & Astrophysics; Physics, Particles & Fields SC Astronomy & Astrophysics; Physics GA 730KP UT WOS:000185830200013 ER PT J AU Lehman, RA Polly, DW Kuklo, TR Cunningham, B Kirk, KL Belmont, PJ AF Lehman, RA Polly, DW Kuklo, TR Cunningham, B Kirk, KL Belmont, PJ TI Straight-forward versus anatomic trajectory technique of thoracic pedicle screw fixation: A biomechanical analysis SO SPINE LA English DT Article DE biomechanics; bone mineral density; insertional torque; pullout strength; pedicle screw; thoracic spine; spinal fixation ID IDIOPATHIC SCOLIOSIS; LUMBAR SPINE; INTERNAL-FIXATION; OPERATIVE TREATMENT; LUMBOSACRAL SPINE; COTREL-DUBOUSSET; PULLOUT STRENGTH; BONE-DENSITY; PLACEMENT; INSTRUMENTATION AB Study Design. A biomechanical study on cadaveric thoracic vertebrae using pullout strength, insertional torque, and bone mineral density to determine the optimal sagittal trajectory of thoracic pedicle screws. Objective. To perform a biomechanical study on cadaveric thoracic vertebrae using insertion torque, pullout strength, and bone mineral density to determine the optimal biomechanical sagittal trajectory for placement thoracic pedicle screws. We compared the straight-forward (paralleling the vertebral endplate) with anatomic trajectory (directed along the true anatomic axis of the pedicle). Methods. Thirty cadaveric thoracic vertebrae were harvested and evaluated with dual-energy x-ray adsorptiometry to assess bone mineral density. Matched, fixed-head pedicle screws were then randomly assigned by side and placed using the straight-forward or anatomic technique under fluoroscopic visualization while recording the maximum insertin torque. Pullout strength testing was then performed. Results. The maximum insertion torque for the straight-forward technique was 2.58+/-0.14 (SE) in pounds, whereas the anatomic technique averaged 1.86+/-0.14 (SE) in pounds (P=0.0005). The maximum insertional torque at the neurocentral junction for the straight-forward technique averaged 1.89+/-0.17 (SE) in-lbs. (73% of maximum insertional torque), whereas the anatomic trajectory averaged 1.39+/-0.11 (SE) in pounds (75% of maximum insertional torque) (P=0.007). The average pullout strength using a straight-forward trajectory was 611+/-50 (SE) N compared to the anatomic trajectory, which averaged 481+/-54 (SE) N (P=0.034). The pullout strength correlated with mean bone mineral density for both the straight-forward (r=0.461, P=0.027) and anatomic (r=0.598, P=0.004) techniques. Conclusions. The straight-forward technique results in a 39% increase in maximum insertional torque and a 27% increase in pullout strength compared to the anatomic technique. The maximum insertional torque at the neurocentral junction resulted in a 36% increase using the straight-forward technique versus the anatomic trajectory. Bone mineral density directly correlated with pullout strength for both techniques. C1 Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. Union Mem Hosp, Orthopaed Biomech Lab, Baltimore, MD USA. RP Lehman, RA (reprint author), 1224 Crockett Lane, Silver Spring, MD 20904 USA. OI Belmont, Philip/0000-0003-2618-199X NR 44 TC 76 Z9 83 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD SEP 15 PY 2003 VL 28 IS 18 BP 2058 EP 2065 DI 10.1097/01.BRS.0000087743.57439.4F PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 724QK UT WOS:000185498100004 PM 14501914 ER PT J AU Kuklo, TR Lehman, RA AF Kuklo, TR Lehman, RA TI Effect of various tapping diameters on insertion of thoracic pedicle screws: A biomechanical analysis SO SPINE LA English DT Article DE biomechanics; tapping; bone mineral density; insertional torque; pedicle screw; thoracic spine; spinal fixation ID PULLOUT STRENGTH; IDIOPATHIC SCOLIOSIS; LUMBOSACRAL SPINE; HOLE PREPARATION; FIXATION; LUMBAR; TORQUE; VERTEBRAE; PLACEMENT AB Study Design. A biomechanical cadaver study to assess the effect of various tapping diameters on thoracic pedicle screw insertional torque. Summary of Background Data. Thoracic pedicle screws are now commonly used for deformity and nondeformity cases. The optimal insertion techniques, however, have not been determined. Purpose. To investigate the effect of various tapping techniques before insertion of thoracic pedicle screws in terms of maximal insertional torque (MIT) or screw pullout. Materials and Methods. Thirty-four fresh cadaveric thoracic vertebrae were harvested and evaluated with dual-energy radiograph absorptiometry (DEXA) to assess bone mineral density (BMD). Twenty-three matched, fixed head, 5.0-mm pedicle screws (group 1) were placed using the straight-forward (ST) trajectory (paralleling the endplate) at various thoracic levels after random side selection using either line-to-line tapping (5.0-mm tap) or 1-mm undertapping (4.0-mm tap) under direct and fluoroscopic visualization. After this, 11 matched 5.0-mm pedicle screws (group 2) were placed comparing undertapping by 0.5-mm (4.5-mm tap) with 1 mm undertapping (4.0-mm tap). MIT was recorded for each screw revolution with a digital torque wrench. Results. BMD averaged 0.732 g/cm(2) (0.620-0.884 g cm(2)) for group 1, and 614 g/cm(2) (0.533-0.697 g/cm(2)) for group 2. In group 1, the average MIT was 0.153+/-0.009 (SE) Nm for line-to-line taping and 0.295+/-0.021 (SE) Nm for 1 mm undertapping, a 93% increase in MIT (P<0.0005). In group 2, the average MIT was 0.138&PLUSMN;0.009 (SE) Nm for 0.5 mm undertapping and 0.202&PLUSMN;0.018 (SE) Nm for undertapping by 1 mm, a 47% increase in MIT (P=0.03). BMD correlated with undertapping by 1 mm in group 1 (P<0.0005), but not with undertapping by 0.5 mm (P=0.087), although there appeared to be a trend in osteoporotic specimens. There were no noted differences in MIT between thoracic regions/levels, despite small differences in thoracic pedicle widths (P=0.193). Discussion and Conclusion. Undertapping the thoracic pedicle by 1-mm increases MIT by 47% (P=0.03) when compared with undertapping by 0.5 mm, and by 93% (P<0.0005) when compared with tapping line-to-line. C1 Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Union Mem Hosp, Baltimore, MD USA. RP Kuklo, TR (reprint author), 15619 Thistlebridge Lane, Rockville, MD 20853 USA. NR 26 TC 44 Z9 48 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD SEP 15 PY 2003 VL 28 IS 18 BP 2066 EP 2071 DI 10.1097/01.BRS.0000084665.31967.02 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 724QK UT WOS:000185498100005 PM 14501915 ER PT J AU Lehman, RA Kuklo, TR AF Lehman, RA Kuklo, TR TI Use of the anatomic trajectory for thoracic pedicle screw salvage after failure/violation using the straight-forward technique: A biomechanical analysis SO SPINE LA English DT Article DE biomechanics; bone mineral density; insertional torque; salvage; pedicle screw; thoracic spine; spinal fixation ID CALCIUM-PHOSPHATE CEMENT; BONE-MINERAL DENSITY; IDIOPATHIC SCOLIOSIS; INSERTIONAL TORQUE; PULLOUT STRENGTH; LUMBAR SPINE; FIXATION; PLACEMENT; REVISION; MODEL AB Study Design. A biomechanical study of cadaver vertebrae to determine the feasibility of obtaining adequate thoracic pedicle screw fixation in a salvage situation. Objective. To investigate the ability to safely place a thoracic pedicle screw with adequate maximal insertional torque (MIT) using the anatomic trajectory (AT) (directed along the true anatomic axis of the pedicle) after purposeful failure/medial violation of the pedicle using the straight-forward trajectory (ST) (paralleling the vertebral endplate). Summary and Background Data. Failure to place a pedicle screw at an intended segment of the thoracic spine may theoretically render the level uninstrumented, because pedicle hook placement may be unsafe and the transverse process may be fractured. An alternative pedicle screw insertion technique, if biomechanically sound in this situation, may present an excellent alternative for critical instrumentation levels. Materials and Methods. Fixed-head 5.0 mm stainless steel pedicle screws were placed using the ST and MIT was recorded after determination of bone mineral density (BMD) with dual-energy radiograph absorptiometry (DEXA) scanning. Purposeful screw malposition and critical pedicle wall failure were performed, followed by salvage placement of the screw using the AT. Insertional torque was recorded for each screw revolution with a digital torque wrench and MIT was again recorded to compare the MIT obtainable in the salvage situation. Results. BMD for the vertebrae averaged 732 g/cm(2) (620-884 g/cm(2)). The MIT for the straight-forward technique without pedicle violation was 2.61+/-0.19 (SE) inches per pound, whereas that of the salvage procedure after medial wall violation (AT) averaged 1.62+/-0.12 (SE) inches per pound. Therefore, the AT achieved 62% (P=0.027) of the fixation strength (in terms of MIT) during salvage after failure/medial violation of the pedicle. MIT for both the ST* and AT trajectories correlated with both global BMD of the vertebrae (*P=0.008; P=0.004) and regional BMD of the vertebral body (*P=0.044; P=0.023). Conclusions. The AT achieved 62% (P=0.027) of the MIT during salvage of a failed/violated pedicle. BMD correlated with both the initial and salvage techniques. The AT provides adequate fixation in a salvage situation and may be safely used to provide segmental fixation at critical levels. C1 Walter Reed Army Med Ctr, Dept Orthopaed Surg, Washington, DC 20307 USA. RP Kuklo, TR (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed Surg, Washington, DC 20307 USA. NR 30 TC 38 Z9 49 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD SEP 15 PY 2003 VL 28 IS 18 BP 2072 EP 2077 DI 10.1097/01.BRS.0000084628.37133.BA PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 724QK UT WOS:000185498100006 PM 14501916 ER PT J AU Sanders, JO Polly, DW Cats-Baril, W Jones, J Lenke, LG O'Brien, MF Richards, BS Sucato, DJ AF Sanders, JO Polly, DW Cats-Baril, W Jones, J Lenke, LG O'Brien, MF Richards, BS Sucato, DJ CA AIS Section Spinal Deformity Study TI Analysis of patient and parent assessment of deformity in idiopathic scoliosis using the Walter Reed Visual Assessment Scale SO SPINE LA English DT Article DE scoliosis; appearance; cosmesis; outcomes instrument; visible deformity ID QUALITY-OF-LIFE; SPINE DEFORMITIES; FOLLOW-UP; ADOLESCENTS; INSTRUMENT; OUTCOMES; SURGERY; BRACE; VALIDATION AB Objectives. This study evaluates the Walter Reed Visual Assessment Scale (WRVAS) compared with clinical parameters and written descriptions of the deformity from idiopathic scoliosis patients and their parents. Summary of Background Data. The WRVAS demonstrates seven visible aspects of spinal deformity in an analogue scale. Higher scores reflect worsening deformity. Materials and Methods. The WRVAS was administered to 182 idiopathic scoliosis patients at four centers in conjunction with open-ended questions about patients; and their parents' perceptions of their spinal deformity. The open-ended responses were categorized as either "deformity noted" or "No deformity noted." Results. WRVAS scores strongly correlate with curve magnitude (P=0.01) and clearly differentiates curves of 30degrees or more from lesser curves. Among treatment groups, patients with surgery recommended had significantly higher scores than that of other patients. The instrument differentiated those noting no deformity from those noting a deformity. The correlation between patients; and parents' scores was high. (Spearman's rho=0.8). When a deformity was noted parents gave higher scores than did their children for rib prominence, shoulder level, scapular rotation, and the total score, but not for the other dimensions. Conclusions. Increasing scores of the WRVAS are strongly correlated with curve magnitude lending construct validity to this type of assessment tool. Patients with "surgery recommended" report more visible deformity on the scale than observed, braced, and postoperative patients, supporting the hypothesis that surgery improves the perceived appearance. Parents perceive more deformity of the ribs and shoulders more than did the patients, but other aspects of the deformity are identified equally. WRVAS scores correlate significantly with curve magnitude and treatment. Parents and patients have similar scores, but with parents perceiving more deformity of the ribs and shoulders than patients. C1 Shriners Hosp Children, Erie, PA 16505 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Vermont, Burlington, VT USA. Data Harbor, Chicago, IL USA. Medtron Sofamor Danek, Memphis, TN USA. Washington Univ, St Louis, MO USA. Denver Orthoped, Wheat Ridge, CO USA. Texas Scottish Rite Hosp Crippled Children, Dallas, TX USA. RP Sanders, JO (reprint author), Shriners Hosp Children, Erie, PA 16505 USA. NR 22 TC 45 Z9 49 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD SEP 15 PY 2003 VL 28 IS 18 BP 2158 EP 2163 DI 10.1097/01.BRS.0000084629.97042.0B PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 724QK UT WOS:000185498100019 PM 14501929 ER PT J AU Hevey, M Negley, D Schmaljohn, A AF Hevey, M Negley, D Schmaljohn, A TI Characterization of monoclonal antibodies to Marburg virus (strain Musoke) glycoprotein and identification of two protective epitopes SO VIROLOGY LA English DT Article DE Filoviridae; hemorrhagic fever; Marburg virus; antibodies; epitope; protection ID HEMORRHAGIC-FEVER; GUINEA-PIGS; ZAIRE; VACCINES AB Monoclonal antibodies (MAbs) reactive with Marburg virus (strain Musoke) were evaluated for both biological activity and specificity. Several of the Marburg virus- (MBGV) specific MAbs reduced the size and/or number of MBGV plaques in vitro. The ability of the MAbs to affect plaque formation in vitro was demonstrated to be specific for the glycoprotein (GP) of the strain of MBGV used for vaccination. Using deletion analysis and peptide mapping, the binding epitopes of several of these neutralizing MAbs were identified. Not unexpectedly, the epitopes were shown to lie in the most hypervariable and highly glycosylated region of MBGV GP. An analysis of the in vivo activity of several MAbs revealed that some antibodies provided substantial but incomplete protection of naive guinea pigs by passive transfer. These data suggest that neutralizing epitopes exist within MBGV GP but that induction of antibodies to these neutralizing epitopes may not be sufficient for protection from lethal infection. (C) 2003 Elsevier Inc. All rights reserved. C1 USA, Med Res Inst Infect Dis, Dept Viral Pathogenesis & Immunol, Div Virol, Frederick, MD 21702 USA. RP Hevey, M (reprint author), USA, Med Res Inst Infect Dis, Dept Viral Pathogenesis & Immunol, Div Virol, Frederick, MD 21702 USA. NR 15 TC 27 Z9 27 U1 1 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD SEP 15 PY 2003 VL 314 IS 1 BP 350 EP 357 DI 10.1016/S0042-6822(03)00416-1 PG 8 WC Virology SC Virology GA 728PT UT WOS:000185726100034 PM 14517087 ER PT J AU Le Roch, KG Zhou, YY Blair, PL Grainger, M Moch, JK Haynes, JD De la Vega, P Holder, AA Batalov, S Carucci, DJ Winzeler, EA AF Le Roch, KG Zhou, YY Blair, PL Grainger, M Moch, JK Haynes, JD De la Vega, P Holder, AA Batalov, S Carucci, DJ Winzeler, EA TI Discovery of gene function by expression profiling of the malaria parasite life cycle SO SCIENCE LA English DT Article ID PLASMODIUM-FALCIPARUM; STABLE TRANSFECTION; ANTIGENIC VARIATION; EBL FAMILY; SEQUENCE; PROTEIN; SPOROZOITE; CHROMOSOME-2; SURFACE; KINASE AB The completion of the genome sequence for Plasmodium falciparum, the species responsible for most malaria human deaths, has the potential to reveal hundreds of new drug targets and proteins involved in pathogenesis. However, only similar to35% of the genes code for proteins with an identifiable function. The absence of routine genetic tools for studying Plasmodium parasites suggests that this number is unlikely to change quickly if conventional serial methods are used to characterize encoded proteins. Here, we use a high-density oligonucleotide array to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle. Genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes. C1 Scripps Res Inst, Dept Cell Biol ICND202, La Jolla, CA 92037 USA. Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA. USN, Med Res Ctr, Malaria Program, Silver Spring, MD 20910 USA. Natl Inst Med Res, Div Parasitol, London NW7 1AA, England. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. RP Le Roch, KG (reprint author), Scripps Res Inst, Dept Cell Biol ICND202, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA. RI Holder, Anthony/A-7554-2013 OI Holder, Anthony/0000-0002-8490-6058 FU Medical Research Council [MC_U117532067] NR 44 TC 782 Z9 796 U1 5 U2 54 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD SEP 12 PY 2003 VL 301 IS 5639 BP 1503 EP 1508 DI 10.1126/science.1087025 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 720HL UT WOS:000185255300040 PM 12893887 ER PT J AU Fu, RQ Ma, ZR Zheng, JP Au, G Plichta, EJ Ye, CH AF Fu, RQ Ma, ZR Zheng, JP Au, G Plichta, EJ Ye, CH TI High-resolution (7Li solid-state NMR study of Li)(V)(O)(x)(2)(5) cathode electrodes for Li-rechargeable batteries SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID SPIN-LATTICE RELAXATION; NUCLEAR-MAGNETIC-RESONANCE; LITHIUM INTERCALATION; HARD-CARBON; DEGRADATION MECHANISM; C-13; CONDUCTIVITY; INSERTION; CELLS AB The LixV2O5 cathode of Li-rechargeable battery cells under three different charge states have been studied by high-resolution solid-state Li-7 magic angle spinning (MAS) NMR spectroscopy. In the charged and discharged states, three different Li-7 NMR resonances, corresponding to the Li+ ions in the electrolyte, in the V2O5 cathode, and on the surface of the V2O5 cathode, were identified by their spin-lattice relaxation times in inversion recovery experiments. Only signals of the Li+ ions in the electrolyte were observed in the over charged state. It is shown experimentally that the Li+ ions in the electrolyte experience a dynamics or exchange process in a time scale of milliseconds with those in the V2O5 cathode, in particular for the discharged state, where a severe cross relaxation effect was observed in the inversion recovery for the Li+ ions in the electrolyte. It is concluded that such an exchange is mediated by the Li+ ions on the surface of the V2O5 cathode. Therefore, the surface structure of the V2O5 cathode electrode plays an important role in the reversibility of the Li+ ions in the rechargeable battery. C1 Ctr Interdisciplinary Magnet Resonance, Natl High Magnet Field Lab, Tallahassee, FL 32310 USA. Florida A&M Univ, Dept Elect & Comp Sci, Tallahassee, FL 32310 USA. Florida State Univ, Tallahassee, FL 32310 USA. USA, Commun Elect Command, Ft Monmouth, NJ 07703 USA. Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China. RP Fu, RQ (reprint author), Ctr Interdisciplinary Magnet Resonance, Natl High Magnet Field Lab, 1800 E Paul Dirac Dr, Tallahassee, FL 32310 USA. NR 29 TC 11 Z9 11 U1 0 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD SEP 11 PY 2003 VL 107 IS 36 BP 9730 EP 9735 DI 10.1021/jp0305077 PG 6 WC Chemistry, Physical SC Chemistry GA 719YX UT WOS:000185233600018 ER PT J AU Jung, KH Park, SH Chang, GY AF Jung, KH Park, SH Chang, GY TI Imitative arm levitation from a recurrent right thalamic hemorrhage: A case report SO NEUROLOGY LA English DT Editorial Material ID ALIEN HAND SYNDROME; ASYMMETRIES; PALSY C1 Seoul Natl Univ Hosp, Dept Neurol, Seoul 110744, South Korea. Seoul Municipal Boramae Hosp, Seoul, South Korea. 121st US Army Gen Hosp, Dept Neurol, Seoul, South Korea. RP Chang, GY (reprint author), HHC 121st Gen Hosp, MC, LTC, Box 277, APO, AP 96205 USA. RI Park, Seong Ho/J-5488-2012 NR 7 TC 2 Z9 2 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD SEP 9 PY 2003 VL 61 IS 5 BP 718 EP 718 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA 719CX UT WOS:000185187000034 PM 12963778 ER PT J AU Banerjee, D Lao, JY Wang, DZ Huang, JY Ren, ZF Steeves, D Kimball, B Sennett, M AF Banerjee, D Lao, JY Wang, DZ Huang, JY Ren, ZF Steeves, D Kimball, B Sennett, M TI Large-quantity free-standing ZnO nanowires SO APPLIED PHYSICS LETTERS LA English DT Article ID ZINC-OXIDE NANOWIRES; CATALYTIC GROWTH AB Large-quantity (grams) one-dimensional ZnO nanowires of different sizes have been synthesized by a simple thermal evaporation of ZnO powder in a tube furnace at a temperature controlled to 1000-1200 degreesC and pressure to 1-2 Torr air. A mixture of ZnO and graphite powder was used as the source. Fine graphite flakes were used to promote the growth. The graphite flakes are the key for large-quantity yield and were easily removed by oxidation in flowing O-2 at about 700 degreesC for 1-3 h. The scanning- and transmission-electron-microscopic studies show that the diameter and length of the nanowires vary from 20 to 100 nm and 0.5 to 10 mum, respectively. Room temperature photoluminescence studies found that the luminescent intensity depends on the processing conditions. A reduced band edge ultraviolet (380 nm) and deep-band green (520 nm) emission have been observed for these nanowires. Most importantly, the method can be extended to any other oxide nanowires that will be the building block of future nanoscale devices. (C) 2003 American Institute of Physics. C1 Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA. USA, Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA 01760 USA. RP Ren, ZF (reprint author), Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA. RI Mote, Rakesh/A-9534-2009; Huang, Jianyu/C-5183-2008; Ren, Zhifeng/B-4275-2014 NR 14 TC 143 Z9 150 U1 3 U2 26 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 8 PY 2003 VL 83 IS 10 BP 2061 EP 2063 DI 10.1063/1.1609036 PG 3 WC Physics, Applied SC Physics GA 717LJ UT WOS:000185089800052 ER PT J AU Mosurkal, R Samuelson, LA Kumar, J AF Mosurkal, R Samuelson, LA Kumar, J TI Biocatalytic synthesis of the conjugated bridging ligand tetrapyrido[3,2-a : 2 ',3 '-c : 3 '',2 ''-h : 2 ''',3 '''-j]phenazine (tpphz) and a dinuclear ruthenium complex SO INORGANIC CHEMISTRY LA English DT Article ID ENERGY AB We have synthesized a fully conjugated aromatic bridging ligand, tetrapyrido[3,2-a:2',3'-c:3",2"-h:2"',3"'-j]phenazine (tpphz), and a dinuclear ruthenium complex using Hematin as a biocatalyst. C1 Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. USA, Natick Soldier Ctr, Dev & Engn Command, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Ctr Adv Mat, 265 Riverside St, Lowell, MA 01854 USA. RI MOSURKAL, RAVI/P-6981-2015 NR 15 TC 4 Z9 4 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0020-1669 J9 INORG CHEM JI Inorg. Chem. PD SEP 8 PY 2003 VL 42 IS 18 BP 5450 EP 5452 DI 10.1021/ic034197i PG 3 WC Chemistry, Inorganic & Nuclear SC Chemistry GA 719RZ UT WOS:000185219500001 PM 12950182 ER PT J AU Mait, JN Athale, R van der Gracht, J AF Mait, JN Athale, R van der Gracht, J TI Evolutionary paths in imaging and recent trends SO OPTICS EXPRESS LA English DT Article ID SPATIAL COHERENCE; EXTENDED DEPTH; SYSTEMS; RECONSTRUCTION; INFORMATION; SENSORS; THEOREM; FIELD AB An examination of recent trends in imaging reveals a movement toward systems that balance processing between optics and electronics. Imaging applications include conventional imaging to produce visually pleasing images, special purpose imaging whose output is also an image but with enhanced characteristics, and functional imaging to produce information about a scene from optical data. We identify three approaches to computational imaging that are capable of achieving these goals: wavefront encoding, multiplex imaging, and feature extraction. (C) 2003 Optical Society of America. C1 USA, Res Lab, AMSRL SE EM, Adelphi, MD 20783 USA. Microsyst Technol Off, DARPA, Arlington, VA 22203 USA. HoloSpex, Columbia, MD 21044 USA. RP Mait, JN (reprint author), USA, Res Lab, AMSRL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jmait@arl.army.mil NR 31 TC 36 Z9 37 U1 2 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 8 PY 2003 VL 11 IS 18 BP 2093 EP 2101 DI 10.1364/OE.11.002093 PG 9 WC Optics SC Optics GA 719CA UT WOS:000185185000002 PM 19466096 ER PT J AU Pratt, WD Davis, NL Johnston, RE Smith, JF AF Pratt, WD Davis, NL Johnston, RE Smith, JF TI Genetically engineered, live attenuated vaccines for Venezuelan equine encephalitis: testing in animal models SO VACCINE LA English DT Article DE Venezuelan equine encephalitis virus; vaccine; aerosol exposure ID ENCEPHALOMYELITIS VIRUS; STRAIN TC-83; BALB/C MICE; CDNA CLONE; INFECTION; AEROSOL; MUTANTS; PROTECTION; NEUROVIRULENCE; CANDIDATE AB The central objective of this research was to test molecularly defined, live attenuated Venezuelan equine encephalitis virus (VEEV) vaccine candidates that were produced through precise genetic manipulation of rationally selected viral nucleotide sequences. Molecular clones of vaccine candidates were constructed by inserting either three independently attenuating mutations or a PE2 cleavage-signal mutation with a second-site resuscitating mutation into full-length cDNA clones. Vaccine candidate viruses were recovered through DNA transcription and RNA transfection of cultured cells, and assessed in rodent and non-human primate models. Based on results from this assessment, one of the PE2 cleavage-signal mutants, V3526, was determined to be the best vaccine candidate for further evaluation for human use. Published by Elsevier Science Ltd. C1 USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. Univ N Carolina, Sch Med, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA. AlphaVax Inc, Res Triangle Pk, NC 27709 USA. RP Pratt, WD (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. NR 32 TC 52 Z9 53 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 8 PY 2003 VL 21 IS 25-26 BP 3854 EP 3862 DI 10.1016/S0264-410X(03)00328-1 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 719YY UT WOS:000185233700045 PM 12922119 ER PT J AU Riemenschneider, J Garrison, A Geisbert, J Jahrling, P Hevey, M Negley, D Schmaljohn, A Lee, J Hart, MK Vanderzanden, L Custer, D Bray, M Ruff, A Ivins, B Bassett, A Rossi, C Schmaljohn, C AF Riemenschneider, J Garrison, A Geisbert, J Jahrling, P Hevey, M Negley, D Schmaljohn, A Lee, J Hart, MK Vanderzanden, L Custer, D Bray, M Ruff, A Ivins, B Bassett, A Rossi, C Schmaljohn, C TI Comparison of individual and combination DNA vaccines for B. anthracis, Ebola virus, Marburg virus and Venezuelan equine encephalitis virus SO VACCINE LA English DT Article DE Bacillus anthracis; VEEV; EBOV and MARV; DNA vaccines ID PROTECTIVE ANTIGEN GENE; BACILLUS-ANTHRACIS; GUINEA-PIGS; ENCEPHALOMYELITIS VIRUS; MONOCLONAL-ANTIBODIES; NONHUMAN-PRIMATES; MEMBRANE-PROTEINS; IMMUNOGLOBULIN-G; SPORE CHALLENGE; INFECTION AB Multiagent DNA vaccines for highly pathogenic organisms offer an attractive approach for preventing naturally occurring or deliberately introduced diseases. Few animal studies have compared the feasibility of combining unrelated gene vaccines. Here, we demonstrate that DNA vaccines to four dissimilar pathogens that are known biowarfare agents, Bacillus anthracis, Ebola (EBOV), Marburg (MARV), and Venezuelan equine encephalitis virus (VEEV), can elicit protective immunity in relevant animal models. In addition, a combination of all four vaccines is shown to be equally as effective as the individual vaccines for eliciting immune responses in a single animal species. These results demonstrate for the first time the potential of combined DNA vaccines for these agents and point to a possible method of rapid development of multiagent vaccines for disparate pathogens Such as those that might be encountered in a biological attack. (C) 2003 Elsevier Ltd. All rights reserved. C1 USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD 21702 USA. RP Schmaljohn, C (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. NR 52 TC 87 Z9 89 U1 2 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 8 PY 2003 VL 21 IS 25-26 BP 4071 EP 4080 DI 10.1016/S0264-410X(03)00362-1 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 719YY UT WOS:000185233700070 PM 12922144 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determinations of benzvalene SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; benzvalene; tricyclo[3.1.0.0(2,6)]hex-3-ene ID BENZENE VALENCE ISOMERS; AB-INITIO CALCULATIONS; DEWAR BENZENE; 5,6-DISUBSTITUTED BICYCLO<2.1.1>HEXENES; RADICAL CATION; PHOTOCHEMISTRY; ISOMERIZATION; ENERGY; HYDROCARBONS; PHOTOLYSIS AB The vibrational frequencies and corresponding normal mode assignments of benzvalene are examined theoretically using the GAUSSIAN 98 set of quantum chemistry codes. All normal modes were successfully assigned to one of the six types of motion predicted by a group theoretical analysis (C-H stretch, C-C stretch, C=C stretch, CH wag, C-C=C bend, and C-C-C=C torsion) utilizing the C-2v symmetry of the molecule. The molecular orbitals of benzvalene are also examined. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSSB, RRT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSSB, RRT,DP, Aberdeen Proving Ground, MD 21010 USA. NR 92 TC 0 Z9 0 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD SEP 5 PY 2003 VL 634 BP 41 EP 52 DI 10.1016/S0166-1280(03)00236-7 PG 12 WC Chemistry, Physical SC Chemistry GA 722MZ UT WOS:000185380800005 ER PT J AU Park, SY Interrante, LV Farmer, BL AF Park, SY Interrante, LV Farmer, BL TI Packing studies on poly(di-n-alkylsilylenemethylene)s SO MACROMOLECULAR RAPID COMMUNICATIONS LA English DT Article DE crystal structures; electron diffraction; molecular modeling; poly(di-n-alkylsilylenemethylene); X-ray ID SILICON-CARBIDE; POLY(SILYLENEMETHYLENES); POLY(SILAETHYLENE); POLYCARBOSILANES; POLYMERS; ANALOG; ATOMS AB The packing of poly(di-n-alkylsilylenemethylene) (PDASMs) chains was studied by using X-ray, electron diffraction, and molecular modeling methods. X-ray and electron diffraction measurements revealed unit cells in which the PDASMs were efficiently packed. The PDASM with the longer alkyl side chains, such as poly(di-n-propylsilyenemethylene). (PDSM), showed packing with the alkyl side chains interlocked with each other like cross-shaped gears in the two-dimensional monoclinic unit cell. The PDASM with the shorter ethyl substituent, poly(di-n-ethylsilylenemethylene) (PDESM), showed a lack of ability to interlock its side chains due to the short length of the alkyl groups. In these studies, we found that the length of the alkyl side chains could change the packing arrangement of PDASMs from monoclinic to orthorhombic to hexagonal with only short-range order as the alkyl side chain length decreases at room temperature. C1 Kyungpook Natl Univ, Dept Polymer Sci, Taegu 702701, South Korea. Rensselaer Polytech Inst, Dept Chem, Troy, NY 12180 USA. USA, Res Lab, AFRL MLBP, Wright Patterson AFB, OH 45533 USA. RP Kyungpook Natl Univ, Dept Polymer Sci, Taegu 702701, South Korea. EM psy@knu.ac.kr NR 20 TC 0 Z9 0 U1 0 U2 1 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1022-1336 EI 1521-3927 J9 MACROMOL RAPID COMM JI Macromol. Rapid Commun. PD SEP 3 PY 2003 VL 24 IS 13 BP 793 EP 798 DI 10.1002/marc.200350028 PG 6 WC Polymer Science SC Polymer Science GA 721KG UT WOS:000185315100007 ER PT J AU Ammann, JR Crowe, M West, J AF Ammann, JR Crowe, M West, J TI Asymmetric synthesis of novel trifluoromethyl substituted epinephrine derivatives. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 US Army Dent Res Detachment, Chem Branch, Great Lakes, IL 60088 USA. EM jeffreyammann@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 615-ORGN BP U218 EP U218 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062501091 ER PT J AU Bednar, AJ Larson, SL Gent, D Gilmore, J Malone, P Weiss, C Christodoulatos, C Manis, R Dermatas, D AF Bednar, AJ Larson, SL Gent, D Gilmore, J Malone, P Weiss, C Christodoulatos, C Manis, R Dermatas, D TI Mobility and containment of thorium-232 in soil at a military training site. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 USA, Engn Res & Dev Ctr, Environm Chem Branch, EP C, Vicksburg, MS 39180 USA. Stevens Inst Technol, Hoboken, NJ 07030 USA. EM Anthony.J.Bednar@erdc.usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 34-NUCL BP U78 EP U78 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062500405 ER PT J AU Deitzel, JM Krauthauser, C Harris, D Perganis, C Kleinmeyer, J AF Deitzel, JM Krauthauser, C Harris, D Perganis, C Kleinmeyer, J TI Real time imaging of particulate motion in electrostatically driven jets of polymer solution. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. USA, Res Lab, Polymers Res Branch, Div Mat, Washington, DC USA. XIOtech Corp, Eden Prairie, MN USA. EM deitzel@ccm.udel.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 459-POLY BP U424 EP U424 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062502223 ER PT J AU Dhar, RK Zheng, Y Robenstone, J van Geen, A AF Dhar, RK Zheng, Y Robenstone, J van Geen, A TI A rapid colorimetric method for measuring arsenic concentrations in groundwater. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NY SP Amer Chem Soc C1 CUNY Queens Coll, Sch Earth & Environm Sci, New York, NY USA. CUNY, Grad Sch & Univ Ctr, New York, NY 10021 USA. USA, Flushing, NY 11367 USA. Columbia Univ, Sch Earth & Environm Sci, New York, NY USA. Columbia Univ, Lamont Doherty Earth Observ, New York, NY 10027 USA. EM rdhar@ldeo.columbia.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 084-GEOC BP U595 EP U595 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JF UT WOS:000187062402827 ER PT J AU Drew, C Ku, BC Wang, XY Samuelson, LA Kumar, J AF Drew, C Ku, BC Wang, XY Samuelson, LA Kumar, J TI Electrostatic assembly of titanium dioxide on surface functionalized electrospun nanofibers. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. Univ Massachusetts, Dept Chem & Phys, Lowell, MA 01854 USA. US Army Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA USA. EM cdrew98@yahoo.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 570-POLY BP U442 EP U442 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062502332 ER PT J AU Fedele, PD AF Fedele, PD TI Military test methods for chemical protective ensembles. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NY SP Amer Chem Soc C1 USA, Soldier & Biol Chem Command, Improved Response Program, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 181-ANYL BP U129 EP U129 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JF UT WOS:000187062400569 ER PT J AU Gersten, BL Synowczynski, J Hirsch, SG AF Gersten, BL Synowczynski, J Hirsch, SG TI Study of the morphology of hydrothermally prepared nanosized titania particulates. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NY SP Amer Chem Soc C1 CUNY Queens Coll, Dept Chem & Biochem, Flushing, NY 11367 USA. USA, Res Lab, Washington, DC USA. EM bgersten@qcl.qc.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 125-INOR BP U691 EP U691 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JF UT WOS:000187062403237 ER PT J AU Gogolak, C Petullo, C Klawiter, K Lloyd, V Meck, R Peterson, H Doremus, S Caputo, D Alberth, D Powers, G Huffert, A Fragoso, L Bhat, R AF Gogolak, C Petullo, C Klawiter, K Lloyd, V Meck, R Peterson, H Doremus, S Caputo, D Alberth, D Powers, G Huffert, A Fragoso, L Bhat, R TI Multi-Agency Radiation Survey and Site Investigation Manual (MARSSIM) supplements: Overview/development update. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 US Dept Homeland Secur, Environm Measurements Lab, New York, NY 10014 USA. US EPA, OSWER ERT, Las Vegas, NV 89193 USA. US EPA, ORIA HQ, Las Vegas, NV 89193 USA. US EPA, ORIA NAREL, Las Vegas, NV 89193 USA. US Nucl Regulatory Commiss, Washington, DC 20555 USA. US Dept Energy EH, Washington, DC USA. USN, Washington, DC USA. USAF, Washington, DC 20330 USA. USA, Washington, DC 20310 USA. EM cvg@eml.doe.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 7-NUCL BP U73 EP U73 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062500378 ER PT J AU Gu, ZF Januskiewicz, AJ AF Gu, ZF Januskiewicz, AJ TI Effects of brief exposure to high concentrations of nitric oxide-air mixtures on breathing in awake rats. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NY SP Amer Chem Soc C1 Walter Reed Army Inst Res, Dept Resp Res, Silver Spring, MD 20910 USA. EM zengfa.gu@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 067-TOXI BP U328 EP U328 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JF UT WOS:000187062401512 ER PT J AU Korte, WD Smith, JR Capacio, BR DeLion, M Anderson, DR AF Korte, WD Smith, JR Capacio, BR DeLion, M Anderson, DR TI Monitoring sulfur mustard exposure by the GC-MS analysis of thiodiglycol cleaved from blood proteins. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NY SP Amer Chem Soc C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM william.korte@amedd.army.mil NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 056-ANYL BP U109 EP U109 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JF UT WOS:000187062400448 ER PT J AU Krauthauser, C Deitzel, JM Wetzel, ED O'Brien, D AF Krauthauser, C Deitzel, JM Wetzel, ED O'Brien, D TI Durable transparent materials: Electrospun nanofibers infused with transparent resin. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. USA, Res Lab, Composites & Lightweight Struct Branch, Washington, DC USA. EM krauthau@ccm.udel.edu NR 0 TC 3 Z9 3 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 569-POLY BP U442 EP U442 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062502331 ER PT J AU Nguyen, T Gu, XH VanLandingham, M Ryntz, R Martin, JW AF Nguyen, T Gu, XH VanLandingham, M Ryntz, R Martin, JW TI Degradation mode of polymeric coatings - An AFM study. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Natl Inst Stand & Technol, Building & Fire Res Lab, Gaithersburg, MD 20899 USA. Army Res Lab, Washington, DC USA. Visteon Corp, Dearborn, MI USA. Natl Inst Stand & Technol, Building Mat Grp, Gaithersburg, MD 20899 USA. EM tinh.nguyen@nist.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 119-PMSE BP U476 EP U476 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062502455 ER PT J AU Pati, RK Ehrman, SH Lee, IC Chu, D AF Pati, RK Ehrman, SH Lee, IC Chu, D TI Synthesis of nanocrystalline catalysts for the water-gas shift reaction. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NY SP Amer Chem Soc C1 Univ Maryland, Dept Chem Engn, College Pk, MD 20742 USA. USA, Res Lab, Sensors & Electron Devices Directorate, Washington, DC USA. EM rpati@wam.umd.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 142-FUEL BP U567 EP U567 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JF UT WOS:000187062402682 ER PT J AU Sharma, SK Sharma, AK Kumar, R Parmar, VS Samuelson, LA Kumar, J Watterson, AC AF Sharma, SK Sharma, AK Kumar, R Parmar, VS Samuelson, LA Kumar, J Watterson, AC TI Synthesis of amino functionalized amphiphilic copolymers as potential gene delivery carriers. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Univ Massachusetts, Inst Nanosci Engn & Technol, Ctr Adv Mat, Dept Chem & Phys, Lowell, MA USA. Univ Massachusetts, Dept Chem, Lowell, MA USA. US Army Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA USA. EM Sunil_Sharma@uml.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 81-POLY BP U369 EP U369 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062501849 ER PT J AU Snyder, AP Maswadeh, WM Tripathi, A Eversole, J Ho, J Spence, M AF Snyder, AP Maswadeh, WM Tripathi, A Eversole, J Ho, J Spence, M TI Mass and spectra-based analytical orthogonal technologies for the field detection of biological and chemical aerosols and liquids. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NY SP Amer Chem Soc C1 US Army, US Army Soldier Biol Chem Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 183-ANYL BP U130 EP U130 PN 1 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JF UT WOS:000187062400571 ER PT J AU Thiyagarajan, M Samuelson, LA Kumar, J Cholli, AL AF Thiyagarajan, M Samuelson, LA Kumar, J Cholli, AL TI Biocatalytically synthesized conducting helical polyaniline nanocomposites. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. US Army Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA USA. EM Ashok_Cholli@uml.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 263-POLY BP U395 EP U395 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062502031 ER PT J AU Thiyagarajan, M Samuelson, LA Kumar, J Cholli, AL AF Thiyagarajan, M Samuelson, LA Kumar, J Cholli, AL TI Enzymatically synthesized conducting polyaniline nanocomposites: A solid state NMR study. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Univ Massachusetts, Ctr Adv Mat, Lowell, MA 01854 USA. US Army Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA USA. EM Ashok_Cholli@uml.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 236-POLY BP U390 EP U391 PN 2 PG 2 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062502004 ER PT J AU Tyagi, R Kumar, R Parmar, VS Samuelson, LA Watterson, AC Kumar, J AF Tyagi, R Kumar, R Parmar, VS Samuelson, LA Watterson, AC Kumar, J TI Biocatalytic routes for the synthesis of amino acids containing amphiphilic copolymers for drug delivery applications. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Univ Massachusetts, Inst Nanosci & Engn Technol, Ctr Adv Mat, Lowell, MA 01854 USA. Univ Massachusetts, Dept Chem, Lowell, MA 01854 USA. Univ Massachusetts, Dept Chem & Phys, Lowell, MA 01854 USA. US Army Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA USA. EM Rahul_Tyagi@uml.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 74-POLY BP U368 EP U368 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062501842 ER PT J AU Wang, XY Yang, SZ Drew, C Samuelson, L Kumar, J AF Wang, XY Yang, SZ Drew, C Samuelson, L Kumar, J TI Pyrene surface modified electrospun nanofibrous membranes for sensor application. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 226th National Meeting of the American-Chemical-Society CY SEP 07-11, 2003 CL NEW YORK, NEW YORK SP Amer Chem Soc C1 Univ Massachusetts, Dept Chem, Ctr Adv Mat, Lowell, MA 01854 USA. US Army Soldier & Biol Chem Command, Natick Soldier Ctr, Natick, MA USA. EM xianyan_w@yahoo.com NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD SEP PY 2003 VL 226 MA 568-POLY BP U442 EP U442 PN 2 PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 751JG UT WOS:000187062502330 ER PT J AU Kim, JH Pitisuttithum, P Kamboonruang, C Chuenchitra, T Mascola, J Frankel, SS DeSouza, MS Polonis, V McLinden, R Sambor, A Brown, AE Phonrat, B Rungruengthanakit, K Duliege, AM Robb, ML McNeil, J Birx, DL AF Kim, JH Pitisuttithum, P Kamboonruang, C Chuenchitra, T Mascola, J Frankel, SS DeSouza, MS Polonis, V McLinden, R Sambor, A Brown, AE Phonrat, B Rungruengthanakit, K Duliege, AM Robb, ML McNeil, J Birx, DL CA THAI Aids Vaccine Evaluation Grp TI Specific antibody responses to vaccination with bivalent CM235/SF2 gp120: Detection of homologous and heterologous neutralizing antibody to subtype E (CRF01.AE) HIV type 1 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; CANDIDATE AIDS VACCINES; INJECTING DRUG-USERS; ENVELOPE GLYCOPROTEINS; MONOCLONAL-ANTIBODIES; UNINFECTED RECIPIENTS; OLIGOMERIC GP160; PRIMARY ISOLATE; CLADE-B; INFECTION AB HIV-1 CRF.AE-01 (formerly subtype E) infection is highly prevalent in Southeast Asia. Despite success with public health measures, the development of an effective CRF01.AE vaccine is critical to the control of this epidemic. Sera from the open-label arms of the first clinical trial of a bivalent HIV gp120 SF2/CM235 (subtypes B and CRF.AE-01, respectively) vaccine were evaluated for the presence of gp120-specific binding (BAb) and neutralizing antibody (NAb). Twelve pre- and postvaccination sera pairs were tested for CM235 BAb; anti-gp120 CM235 BAb was found in all postvaccination samples. The 12 pre- and postvaccination (1 month after third vaccination) serum pairs were evaluated in several neutralization formats: heterologous T cell line adapted (TCLA) NP03/H9, homologous CM235/PBMC, CM235/dendritic cell, and CM235M4-C4.6/A3R5. A3R5 is a CCR5(+) T cell line, and CM235M4-C4.6 is the homologous CM235 virus adapted to growth in A3R5 cells. All volunteers developed BAb, but meaningful NAb was not demonstrable against primary isolate CM235. Using the TCLA CRF01.AE virus NP03 in H9 cells, 9 of 12 persons had NAb with a geometric mean titer (GMT) of 46. The CM235M4-C4.6 virus in A3R5 cells also detected NAb in 9 of 12 persons, with a GMT of 41. CM235M4-C4.6/A3R5 detected NAb in two persons with negligible NAb to NP03/H9 and vice versa. Whether the NAb detected by the CM235M4-C4.6/A3R5 system is qualitatively different from those in more traditional NP03/H9 assays will require further study. C1 US Mil HIV Res Program, Rockville, MD 20850 USA. Mahidol Univ, Vaccine Trials Ctr, Bangkok 10700, Thailand. Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Chiron Corp, Emeryville, CA 94608 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Kim, JH (reprint author), US Mil HIV Res Program, Rockville, MD 20850 USA. FU NIAID NIH HHS [AI00950] NR 50 TC 23 Z9 23 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD SEP PY 2003 VL 19 IS 9 BP 807 EP 816 DI 10.1089/088922203769232601 PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 727TF UT WOS:000185675200010 PM 14585211 ER PT J AU Smith, TC Gray, GC Weir, JC Heller, JM Ryan, MAK AF Smith, TC Gray, GC Weir, JC Heller, JM Ryan, MAK TI Gulf War veterans and Iraqi nerve agents at Khamisiyah: Postwar hospitalization data revisited SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE exposure; environmental; exposure; occupational; hospitalization; military medicine; morbidity; Persian Gulf syndrome; veterans ID SELF-REPORTED SYMPTOMS; US VETERANS; HEALTH-STATUS; ILLNESS; EXPOSURE; EXPERIENCE; MORTALITY; SERVICE; TIME AB Chemical warfare agents were demolished by US soldiers at Khamisiyah, Iraq, in March 1991. The authors investigated postwar morbidity for Gulf War veterans, contrasting those who may have been exposed to low gaseous levels of nerve agents and those unlikely to have been exposed. Cox regression modeling was performed for hospitalizations from all causes and hospitalizations from diagnoses within 15 categories during the period March 10, 1991, through December 31, 2000, for the duration of active-duty status. After adjustment for all variables in the model, only two of 37 models suggested that personnel possibly exposed to subclinical doses of nerve agents might be at increased risk for hospitalization from circulatory diseases, specifically cardiac dysrhythmias. Of the 724 hospitalizations for cardiac dysrhythmias, 203 were in the potentially exposed group, slightly higher than expected (risk ratio=1.23, 95% confidence interval: 1.04, 1.44). The increase was small in comparison with potential observational variability, but the findings are provocative and warrant further evaluation. Veterans possibly exposed to nerve agents released by the Khamisiyah demolition were not found to be at increased risk for hospitalizations from any other chronic diseases nearly 10 years after the Gulf War. C1 US Dept Def, Ctr Deployment Hlth Res, Naval Hlth Res Ctr, San Diego, CA 92186 USA. Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA USA. USA, Deployment Environm Surveillance Program, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. RP Smith, TC (reprint author), US Dept Def, Ctr Deployment Hlth Res, Naval Hlth Res Ctr, POB 85122, San Diego, CA 92186 USA. NR 52 TC 27 Z9 27 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD SEP 1 PY 2003 VL 158 IS 5 BP 457 EP 467 DI 10.1093/aje/kwg178 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 716QX UT WOS:000185040800010 PM 12936901 ER PT J AU Harrison, SA Torgerson, S Hayashi, PH AF Harrison, SA Torgerson, S Hayashi, PH TI The natural history of nonalcoholic fatty liver disease: A clinical histopathological study SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID CRYPTOGENIC CIRRHOSIS; OBESE SUBJECTS; RISK-FACTORS; WEIGHT-LOSS; STEATOHEPATITIS AB OBJECTIVES: We aimed to define nonalcoholic steatohepatitis (NASH) histopathological change over time and to correlate changes with clinical characteristics. METHODS: We retrieved nonalcoholic fatty liver cases from our histopathology database covering 1985 to 2001. We also identified patients in clinic with NASH on biopsy >1 yr prior. All patients were evaluated and clinical data obtained in clinic. Those patients qualifying for NASH therapeutic trials underwent liver biopsy pretreatment. One pathologist (S.T.) read all slides using a NASH grading and staging system. RESULTS: A total of 22 patients had repeat biopsies a mean of 5.7 yr (range 1.4-15.7 yr) after the first biopsy. Nine were women, nine had diabetes, 11 had hypertension, and 14 had hyperlipidemia. Mean body mass index was 33.8 kg/m(2) (range 26.5-48.6 yr). Mean age was 50.6 yr (range 33-64 yr). Ten patients (45%) had fibrosis stage 1 or 2, and two patients (9%) had bridging fibrosis or cirrhosis (stage 3 or 4) on first biopsy. Seven (32%) had increases in fibrosis score. Four patients (18%) had decreases in fibrosis score. The percentage of patients with stage 3 or 4 increased from 9% to 18%. In two patients the disease progressed rapidly (fibrosis scores from 1 to 3 in 1.4 yr and from 2 to 4 in 2.6 yr). Only serum AST at last biopsy correlated with histological change, being higher in those with disease. progression. Three patients progressed from steatosis to steatohepatitis with fibrosis. CONCLUSIONS: NASH has a variable histological course. However, one third of. patients have fibrosis progression, and one third of these have rapid progression to advanced fibrosis. Histological progression correlated with higher serum AST but no other clinical factors. Steatosis alone may progress to NASH with fibrosis. (C) 2003 by Am. Coll. of Gastroenterology. C1 Wilford Hall USAF Med Ctr, Dept Gastroenterol, San Antonio, TX USA. Brooke Army Med Ctr, Dept Gastroenterol, San Antonio, TX USA. Brooke Army Med Ctr, Dept Pathol, San Antonio, TX USA. RP Hayashi, PH (reprint author), Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Hepatol Sect, 4200 E 9th Ave,B-154, Denver, CO 80262 USA. NR 14 TC 265 Z9 269 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2003 VL 98 IS 9 BP 2042 EP 2047 DI 10.1016/S0002-9270(03)00622-1 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 726CR UT WOS:000185581000023 PM 14499785 ER PT J AU Howard, BC Kovac, CM Calhoun, BC Hoeldtke, NJ Napolitano, PG AF Howard, BC Kovac, CM Calhoun, BC Hoeldtke, NJ Napolitano, PG TI The effects of a cyclo-oxygenase II inhibitor on placental artery production of thromboxane and prostacyclin SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 23rd Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 03-08, 2003 CL SAN FRANCISCO, CALIFORNIA SP Soc Maternal Fetal Med DE placenta; cyclo-oxygenase II inhibitor; thromboxane; prostacyclin ID ANGIOTENSIN-II; COTYLEDON; STIMULATION; EXPRESSION; PREGNANCY AB OBJECTIVE: The study was undertaken to determine the effects of a cyclo-oxygenase II inhibitor on fetoplacental artery production of prostacyclin and thromboxane A(2.) STUDY DESIGN: Eight placentas were obtained from normal parturients at delivery and four chorionic plate arteries were dissected from each placenta. Arteries were incubated in media alone, media plus angiotensin II (1 X 10(-10) mol), media plus rofecoxib (300 ng/mL), or media plus angiotensin II and rofecoxib. Serial samples were assayed for metabolites of thromboxane B-2 and prostacyclin by enzyme-linked immunosorbent assay. Results were compared by analysis of variance, and P <.05 was considered significant. RESULTS: At 24 hours, 6-keto-prostaglandin F-1alpha. levels in the rofecoxib group (1.74 1.39 ng/mg tissue, P <.01) and the rofecoxib plus angiotensin II group (2.15 1.85 ng/mg tissue, P <.01) were significantly lower than levels in the control group (4.25 +/- 2.03 ng/mg tissue). Thromboxane B-2 levels were lower in the angiotensin 11 group (0.65 +/-, 0.33 ng/mg tissue) than the control group (1.22 +/- 0.70 ng/mg tissue, P <.05). CONCLUSION: Cyclo-oxygenase 11 inhibition decreases the production of prostacyclin in fetoplacental arteries and alters the normal ratio of thromboxane A(2) to prostacyclin. C1 Madigan Army Med Ctr, Tacoma, WA 98431 USA. Rockford Mem Med Ctr, Rockford, IL USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Howard, BC (reprint author), Madigan Army Med Ctr, Tacoma, WA 98431 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD SEP PY 2003 VL 189 IS 3 BP 835 EP 838 DI 10.1067/S0002-9378(03)00844-5 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 728LK UT WOS:000185718500050 PM 14526325 ER PT J AU Lam, GK Whitecar, PW Orton, S Boggess, KA Taylor, DD AF Lam, GK Whitecar, PW Orton, S Boggess, KA Taylor, DD TI Differential expression of TcR-CD3 zeta as evidence for altered immunoregulation in preeclamptic versus normotensive women SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 23rd Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY FEB 03-08, 2003 CL SAN FRANCISCO, CALIFORNIA SP Soc Maternal Fetal Med DE TcR-CD3 zeta protein; T-cell function; preeclampsia ID PREGNANCY; ECLAMPSIA; PROTEINS; CD3-ZETA AB OBJECTIVE: The study was undertaken to exhibit and quantify the difference in modulation of CD3-zeta protein (an integral component of the T-cell receptor) in preeclamptic and normotensive women. STUDY DESIGN: Serum was collected from 10 preeclamptic and 10 normotensive women at 37 weeks' gestation on admission. Jurkat E-61 cells were incubated with the sera (20% volume to volume) and analyzed with Western immunoblot using mouse monoclonal CD3-zeta antibody. Enhanced chemiluminescence and densitometry were used to qualitatively measure zeta expression of the cells. A de novo flow cytometry assay Was developed to quantify the difference in CD3-zeta expression of these cells. Comparsions were performed by t test (P <.05 was significant). RESULTS: Preeclamptic patient sera produced a 2.4-fold increase in CD3-zeta expression than normotensive patients on Western blot (P<.01). Flow cytometry showed that preeclamptic sera had a 1.4-fold higher expression of CD3-zeta compared with normotensive patients (P <.0003). CONCLUSION: TcR/CD3-zeta expression is normally suppressed in pregnancy. Loss of this suppression occurs in preeclamptic patients, implying increased T-cell function. C1 Univ N Carolina, Dept Obstet & Gynecol, Div Maternal Fetal Med, Sch Med, Chapel Hill, NC 27599 USA. Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA. Univ Louisville, Sch Med, Dept Obstet & Gynecol, Div Gynecol Oncol, Louisville, KY 40292 USA. Univ N Carolina, Sch Med, Dept Immunol, Chapel Hill, NC 27514 USA. RP Lam, GK (reprint author), 214 MacNider Bldg,CB7516, Chapel Hill, NC 27703 USA. NR 13 TC 5 Z9 5 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD SEP PY 2003 VL 189 IS 3 BP 843 EP 847 DI 10.1067/S0002-9378(03)00815-9 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 728LK UT WOS:000185718500052 PM 14526327 ER PT J AU Pickhardt, PJ Choi, JHR AF Pickhardt, PJ Choi, JHR TI Electronic cleansing and stool tagging in CT colonography: Advantages and pitfalls with primary three-dimensional evaluation SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article C1 Natl Naval Med Res Inst, Dept Radiol, Bethesda, MD 20889 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Pickhardt, PJ (reprint author), Natl Naval Med Res Inst, Dept Radiol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. NR 8 TC 124 Z9 127 U1 0 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2003 VL 181 IS 3 BP 799 EP 805 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 713MH UT WOS:000184861600047 PM 12933484 ER PT J AU Rexroad, JT Moser, RP Georgia, JD AF Rexroad, JT Moser, RP Georgia, JD TI "Fish" or "fish mouth" vertebrae? SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter C1 USN, Ctr Med, Bethesda, MD 20889 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Rexroad, JT (reprint author), USN, Ctr Med, Bethesda, MD 20889 USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD SEP PY 2003 VL 181 IS 3 BP 886 EP 887 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 713MH UT WOS:000184861600065 PM 12933500 ER PT J AU Buckenmaier, CC Klein, SM Nielsen, KC Steele, SM AF Buckenmaier, CC Klein, SM Nielsen, KC Steele, SM TI Continuous paravertebral catheter and outpatient infusion for breast surgery SO ANESTHESIA AND ANALGESIA LA English DT Article ID BLOCK; PAIN; MANAGEMENT C1 Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA. RP Walter Reed Army Med Ctr, Reg Anesthesia Sect, Anesthesia Serv, Washington, DC 20307 USA. EM chester.buckenmaier@na.amedd.army.mil OI Buckenmaier III, Chester/0000-0003-3623-5525 NR 13 TC 18 Z9 21 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD SEP PY 2003 VL 97 IS 3 BP 715 EP 717 DI 10.1213/01.ANE.0000075836.53838.EB PG 3 WC Anesthesiology SC Anesthesiology GA 714AN UT WOS:000184890300024 PM 12933392 ER PT J AU Eccles, TG Patel, A Verma, A Nicholson, D Lukes, Y Tuttle, RM Francis, GL AF Eccles, TG Patel, A Verma, A Nicholson, D Lukes, Y Tuttle, RM Francis, GL TI Erythropoietin and the erythropoietin receptor are expressed by papillary thyroid carcinoma from children and adolescents. Expression of erythropoietin receptor might be a favorable prognostic indicator SO ANNALS OF CLINICAL AND LABORATORY SCIENCE LA English DT Article DE thyroid; cancer; erythropoietin; erythropoietin receptor ID AGGRESSIVE CLINICAL COURSE; YOUNG-ADULTS; TUMOR ANGIOGENESIS; CANCER; METASTASIS; CELLS; MICE; GENE; ERYTHROLEUKEMIA; RECURRENCE AB Erythropoietin (EPO) and the EPO receptor (EPO-R) have been implicated in solid tumors of the brain, breast, kidney and female genital tract. Based on their expression by a variety of tumors, we hypothesized that EPO and/or EPO-R might be expressed by thyroid cancers. To test this, we determined EPO and EPO-R expression by immunohistochemistry in 17 papillary thyroid carcinomas (PTC) from children and adolescents. Only a minority of PTC (4/17, 24%) expressed EPO, and there were no significant differences between the PTC that did or did not express EPO. In contrast, EPO-R was detected in the majority of PTC (11/17, 65%). The average tumor size (1.5 +/- 0.8 cm), MACIS score (3.6 +/- 0.2) and risk of recurrence (0/11) for the EPO-R(+) PTC were significantly less than those for PTC that failed to express EPO-R (average tumor size = 3.6 +/- 2.4 cm, p = 0.021; average MACIS score = 4.3 +/- 0.7, p = 0.004; recurrence = 3/6, p = 0.029). We conclude that the majority of PTC from children and adolescents express EPO-R, a finding associated with favorable prognostic indicators and a lower risk of recurrence. C1 Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, Dept Endocrinol, New York, NY 10021 USA. RP Francis, GL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones bridge Rd, Bethesda, MD 20814 USA. NR 44 TC 16 Z9 16 U1 0 U2 0 PU INST CLINICAL SCIENCE INC PI PHILADELPHIA PA 1833 DELANCEY PLACE, PHILADELPHIA, PA 19103 USA SN 0091-7370 J9 ANN CLIN LAB SCI JI Ann. Clin. Lab. Sci. PD FAL PY 2003 VL 33 IS 4 BP 411 EP 422 PG 12 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 734CJ UT WOS:000186037400005 PM 14584755 ER PT J AU Waselenko, JK Burrows, A Nelson, DA Lucas, M Ekstrand, J Edenfield, WJ Myhand, RC AF Waselenko, JK Burrows, A Nelson, DA Lucas, M Ekstrand, J Edenfield, WJ Myhand, RC TI Post-transplant interleukin-2 in patients with low-grade lymphoid neoplasms previously treated with fludarabine is limited by hematologic toxicity SO ANNALS OF HEMATOLOGY LA English DT Article DE interleukin-2; chronic lymphocytic; leukemia; non-Hodgkin's lymphoma; fludarabine; hematopoietic stem cell transplantation; neutropenia; thrombocytopenia ID BONE-MARROW-TRANSPLANTATION; CHRONIC LYMPHOCYTIC-LEUKEMIA; STEM-CELL TRANSPLANTATION; NON-HODGKINS-LYMPHOMA; DOSE RECOMBINANT INTERLEUKIN-2; PBSC MOBILIZATION; BLOOD; MALIGNANCIES; DISEASE; THERAPY AB Given the favorable immunologic effects of IL-2 post transplant, we conducted a feasibility study examining rIL-2 1.0x106 IU/m2/day (SQ) beginning on D+14 post-transplant and continuing for 90 days in 12 patients with low-grade lymphoproliferative disorders. Prior to high-dose chemotherapy and autologous peripheral blood stem cell transplantation (HDCT), 11 patients underwent cytoreduction with fludarabine and cyclophosphamide (Flu/Cy); 11 were in complete remission (CR) and one was in partial remission at the time of HDCT. All 12 patients were in CR 90 days post-HDCT. At a median follow-up of 30 (range 3-44) months, seven patients (58%) remain in remission, four are alive with disease, and one has died of disease progression, resulting in an overall survival of 92%. Kaplan-Meier estimates of progression-free survival (PFS) for the group demonstrate a median of 31 (range 3-43) months. Five patients required rIL-2 cessation at 8-58 days after starting the therapy due to hematologic toxicity. These results are comparable to those achieved in other published bone marrow and peripheral blood stem cell transplantion (PBSCT) series without the addition of rIL-2. Furthermore, rIL-2 using this schedule following fludarabine-based cytoreduction was associated with excessive hematologic toxicity. C1 Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. Brooke Army Med Ctr, Hematol Oncol Serv, Ft Sam Houston, TX 78234 USA. RP Waselenko, JK (reprint author), Walter Reed Army Med Ctr, Hematol Oncol Serv, Ward 78,6900 Georgia Ave, Washington, DC 20307 USA. NR 41 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0939-5555 J9 ANN HEMATOL JI Ann. Hematol. PD SEP PY 2003 VL 82 IS 9 BP 552 EP 557 DI 10.1007/s00277-003-0726-x PG 6 WC Hematology SC Hematology GA 720JF UT WOS:000185257100004 PM 12910372 ER PT J AU Chanan-Khan, A Szebeni, J Savay, S Liebes, L Rafique, NM Alving, CR Muggia, FM AF Chanan-Khan, A Szebeni, J Savay, S Liebes, L Rafique, NM Alving, CR Muggia, FM TI Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil): possible role in hypersensitivity reactions SO ANNALS OF ONCOLOGY LA English DT Article DE allergy; anaphylatoxins; cancer chemotherapy; doxorubicin; liposomes; hypersensitivity reactions ID PHASE-II; ANTITUMOR-ACTIVITY; OVARIAN-CANCER; CHEMOTHERAPY; PHARMACOKINETICS; PACLITAXEL; MECHANISM; TOXICITY; DISEASE AB Background: Pegylated liposomal doxorubicin (Doxil(R)) has been reported to cause immediate hypersensitivity reactions (HSRs) that cannot be explained as IgE-mediated (type I) allergy. Previous in vitro and animal studies indicated that activation of the complement (C) system might play a causal role in the process, a proposal that has not been tested in humans to date. Patients and methods: Patients with solid tumors (n=29) treated for the first time with Doxil were evaluated for HSRs and concurrent C activation. HSRs were classified from mild to severe, while C activation was estimated by serial measurement of plasma C terminal complex (SC5b-9) levels. Increases in SC5b-9 were compared in patients with or without reactions, and were correlated with Doxil dose rate. Results: Moderate to severe HSRs occurred in 45% of patients. Plasma SC5b-9 at 10 min after infusion was significantly elevated in 92% of reactor patients versus 56% in the non-reactor group, and the rise was greater in reactors than in non-reactors. We found significant association between C activation and HSRs, both showing direct correlation with the initial Doxil dose rate. Conclusions: C activation may play a key role in HSRs to Doxil. However, low-level C activation does not necessarily entail clinical symptoms, highlighting the probable involvement of further, as yet unidentified, amplification factors. C1 Kaplan Comprehens Canc Ctr, New York, NY USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Membrane Biochem, Washington, DC 20307 USA. RP Chanan-Khan, A (reprint author), Roswell Pk Canc Inst, Elm & Carlton St, Buffalo, NY 14263 USA. NR 29 TC 161 Z9 168 U1 5 U2 23 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0923-7534 J9 ANN ONCOL JI Ann. Oncol. PD SEP PY 2003 VL 14 IS 9 BP 1430 EP 1437 DI 10.1093/annonc/mdg374 PG 8 WC Oncology SC Oncology GA 723NA UT WOS:000185437400015 PM 12954584 ER PT J AU Roy, CJ Baker, R Washburn, K Bray, M AF Roy, CJ Baker, R Washburn, K Bray, M TI Aerosolized cidofovir is retained in the respiratory tract and protects mice against intranasal cowpox virus challenge SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID POXVIRUS INFECTIONS; HPMPC CIDOFOVIR; PHARMACOKINETICS; BIOAVAILABILITY; METABOLISM; SMALLPOX; MONKEYPOX; ADEFOVIR; ANALOGS AB We employed a murine model to test the concept of using an aerosolized, long-acting antiviral drug to protect humans against smallpox. We previously showed that a low dose of aerosolized cidofovir (HPMPC [Vistide]) was highly protective against subsequent aerosolized cowpox virus challenge and was more effective than a much larger dose of drug given by injection, suggesting that aerosolized cidofovir is retained in the lung. Because the nephrotoxicity of cidofovir is a major concern in therapy, delivering the drug directly to the respiratory tract might be an effective prophylactic strategy that maximizes the tissue concentration at the site of initial viral replication, while minimizing its accumulation in the kidneys. In the present study, we found that treating mice with aerosolized C-14-labeled cidofovir (C-14-cidofovir) resulted in the prolonged retention of radiolabeled drug in the lungs at levels greatly exceeding those in the kidneys. In contrast, subcutaneous injection produced much higher concentrations of C-14-cidofovir in the kidneys than in the lungs over the 96-h time course of the study. As further evidence of the protective efficacy of aerosolized cidofovir, we found that aerosol treatment before or after infection was highly protective in mice challenged intranasally with cowpox virus. All or nearly all mice that were treated once by aerosol, from 2 days before to 2 days after challenge, survived intranasal infection, whereas all placebo-treated animals died. C1 USA, Dept Aerobiol & Prod Evaluat, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. USA, Dept Viral Therapeut, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Stillmeadow Corp, Sugar Land, TX 77478 USA. NIAID, Biodef Clin Res Branch, Off Clin Res, NIH, Bethesda, MD 20892 USA. RP Roy, CJ (reprint author), USA, Dept Aerobiol & Prod Evaluat, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 25 TC 21 Z9 24 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2003 VL 47 IS 9 BP 2933 EP 2937 DI 10.1128/AAC.47.9.2933-2937.2003 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 715TH UT WOS:000184988000033 PM 12936997 ER PT J AU Kandidov, VP Kosareva, OG Golubtsov, IS Liu, W Becker, A Akozbek, N Bowden, CM Chin, SL AF Kandidov, VP Kosareva, OG Golubtsov, IS Liu, W Becker, A Akozbek, N Bowden, CM Chin, SL TI Self-transformation of a powerful femtosecond laser pulse into a white-light laser pulse in bulk optical media (or supercontinuum generation) SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID CONICAL EMISSION; CONTINUUM GENERATION; NONLINEAR PROPAGATION; 3RD-HARMONIC GENERATION; ULTRASHORT PULSES; TERAWATT LASER; AIR; FILAMENTATION; GASES; INTENSITY AB We present experimental and theoretical results on white-light generation in the filamentation of a high-power femtosecond laser pulse in water and atmospheric air. We have shown that the high spatio-temporal localization of the light field in the filament, which enables the supercontinuum generation, is sustained due to the dynamic transformation of the light field on the whole transverse scale of the beam, including its edges. We found that the sources of the supercontinuum blue wing are in the rings, surrounding the filament, as well as at the back of the pulse, where shock-wave formation enhanced by self-steepening takes place. We report on the first observation and demonstration of the interference of the supercontinuum spectral components arising in the course of multiple filamentation in a terawatt laser pulse. We demonstrate that the conversion efficiency of an initially narrow laser pulse spectrum into the supercontinuum depends on the length of the filament with high intensity gradients and can be increased by introducing an initial chirp. C1 Moscow MV Lomonosov State Univ, Dept Phys, Ctr Int Laser, Moscow 119992, Russia. Univ Laval, Dept Phys Genie Phys & Opt, Ctr Opt Photon & Laser, St Foy, PQ G1K 7P4, Canada. Max Planck Inst Phys Komplexer Syst, D-01187 Dresden, Germany. Time Domain Corp, Huntsville, AL 35806 USA. USA, Aviat & Missile Command, AMSAM,WS,RD,ST, Huntsville, AL 35898 USA. RP Kosareva, OG (reprint author), Moscow MV Lomonosov State Univ, Dept Phys, Ctr Int Laser, Moscow 119992, Russia. RI Liu, Weiwei/G-7660-2011 OI Liu, Weiwei/0000-0001-6036-9641 NR 71 TC 196 Z9 200 U1 6 U2 47 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD SEP PY 2003 VL 77 IS 2-3 BP 149 EP 165 DI 10.1007/s00340-003-1214-7 PG 17 WC Optics; Physics, Applied SC Optics; Physics GA 731QK UT WOS:000185897800002 ER PT J AU Akozbek, N Becker, A Scalora, M Chin, SL Bowden, CM AF Akozbek, N Becker, A Scalora, M Chin, SL Bowden, CM TI Continuum generation of the third-harmonic pulse generated by an intense femtosecond IR laser pulse in air SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID WHITE-LIGHT CONTINUUM; SUPERCONTINUUM GENERATION; NONLINEAR PROPAGATION; HARMONIC-GENERATION; MOVING FOCUS; IONIZATION; FILAMENTATION; ATMOSPHERE; INDEX; MEDIA AB The continuum generation by intense femtosecond IR laser pulses focused in air including the effect of third-harmonic generation is investigated. We have used a theoretical model that includes the full spatio-temporal dynamics of both the fundamental and the third-harmonic pulses. Results of our numerical calculations show that a two-color filamentation effect occurs, in which the third-harmonic conversion efficiency remains almost constant over the whole filament length. It is found that this effect is rather independent of the wavelength of the input beam and the focal geometry. During the filamentation process the third-harmonic pulse itself generates a broad continuum, which can even overlap with the continuum of the fundamental pulse for the longer pump wavelengths. In consequence, the continuum generation generated by intense IR laser pulses is further extended into the UV. C1 Time Domain Corp, Huntsville, AL 35806 USA. Max Planck Inst Komplexer Syst, D-01187 Dresden, Germany. USA, Aviat & Missile Command, ANSAM,WS,RD,ST, Huntsville, AL 35898 USA. Univ Laval, Dept Phys Genie Phys & Opt, Ctr Opt Photon & Laser, Quebec City, PQ G1K 7P4, Canada. RP Akozbek, N (reprint author), Time Domain Corp, 7057 Old Madison Pike, Huntsville, AL 35806 USA. RI Becker, Andreas/K-4402-2013 NR 39 TC 43 Z9 43 U1 0 U2 5 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD SEP PY 2003 VL 77 IS 2-3 BP 177 EP 183 DI 10.1007/s00340-003-1199-2 PG 7 WC Optics; Physics, Applied SC Optics; Physics GA 731QK UT WOS:000185897800005 ER PT J AU Fedotov, AB Bugar, I Sidorov-Biryukov, DA Serebryannikov, EE Chorvat, D Scalora, M Chorvat, D Zheltikov, AM AF Fedotov, AB Bugar, I Sidorov-Biryukov, DA Serebryannikov, EE Chorvat, D Scalora, M Chorvat, D Zheltikov, AM TI Pump-depleting four-wave mixing in supercontinuum-generating microstructure fibers SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID PHOTONIC-CRYSTAL FIBERS; FEMTOSECOND LASER-PULSES; HOLEY OPTICAL-FIBERS; PARAMETRIC-AMPLIFIER; ANOMALOUS-DISPERSION; CONTINUUM GENERATION; TAPERED FIBERS; AIR; LIGHT; SPECTROSCOPY AB Four-wave mixing processes are shown to provide a high efficiency of non-linear optical frequency conversion and spectral transformation of ultrashort pulses in supercontinuum-generating microstructure fibers. Pump-depleting conversion of 800-nm radiation to the spectral range around 500 nm is achieved by phase-matching the parametric four-wave mixing process for 80-fs Ti:sapphire-laser pulses. The ways to use microstructure fibers for generating frequency-tunable radiation through four-wave mixing with the maximum efficiency of pump-field frequency conversion are discussed. C1 Moscow MV Lomonosov State Univ, Ctr Int Laser, Moscow 119899, Russia. Ctr Int Laser, Bratislava 81219, Slovakia. USA, Aviat & Missile Command, Weapons Sci Directorate, Redstone Arsenal, AL 35898 USA. RP Fedotov, AB (reprint author), Moscow MV Lomonosov State Univ, Dept Phys, Moscow 119899, Russia. RI Serebryannikov, Evgeny/M-2583-2014; Bugar, Ignac/A-6725-2015 OI Bugar, Ignac/0000-0001-5228-9844 NR 50 TC 22 Z9 22 U1 2 U2 7 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD SEP PY 2003 VL 77 IS 2-3 BP 313 EP 317 DI 10.1007/s00340-003-1206-7 PG 5 WC Optics; Physics, Applied SC Optics; Physics GA 731QK UT WOS:000185897800024 ER PT J AU Cabalo, J Sausa, R AF Cabalo, J Sausa, R TI Detection of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) by laser surface photofragmentation-fragment detection spectroscopy SO APPLIED SPECTROSCOPY LA English DT Article DE hexahydro-1,3,5-trinitro-1,3,5-triazine; RDX; laser surface photofragmentation-fragment detection; resonance-enhanced ionization; trace detection of energetic materials ID INDUCED-FLUORESCENCE; TRACE EXPLOSIVES; 2,4,6-TRINITROTOLUENE; SPECTROMETRY; CONSTANTS; BANDS; NO C1 USA, Res Lab, AMSRL, WM,BD, Aberdeen Proving Ground, MD 21005 USA. RP Sausa, R (reprint author), USA, Res Lab, AMSRL, WM,BD, Aberdeen Proving Ground, MD 21005 USA. NR 15 TC 13 Z9 13 U1 0 U2 4 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD SEP PY 2003 VL 57 IS 9 BP 1196 EP 1199 DI 10.1366/00037020360696099 PG 4 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 720RR UT WOS:000185274200022 PM 14611053 ER PT J AU Cassidy, RA Vaughan, GM Pruitt, BA Mason, AD AF Cassidy, RA Vaughan, GM Pruitt, BA Mason, AD TI Xenoestrogens: Do they lower survival after thermal injury? SO ARCHIVES OF ENVIRONMENTAL HEALTH LA English DT Article DE burn injury; heptachlor epoxide; organochlorines; oxychlordane; survival; xenoestrogens ID HYDROCARBON INSECTICIDE RESIDUES; ISCHEMIA-REPERFUSION INJURY; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; ESTROGEN-RECEPTOR; ADIPOSE-TISSUE; IN-VIVO; LEUKOCYTE ADHESION; GENDER-DIFFERENCES; STROMAL CELLS AB The effect of hormone disruptors on human health is an area of recent concern. The authors measured heptachlor epoxide and oxychlordane-the body storage forms of estrogenic insecticides-in the sera of patients with major burns (i.e., 7 survivors and 10 age- and burn-size-matched nonsurvivors) on days 1, 3, 5, 7, and 11 after they had been burned, as well as in 12 age-matched normal controls. During the hypermetabolic phase, serum concentrations of heptachlor epoxide and oxychlordane were greater in nonsurvivors than in controls, and heptachlor epoxide concentrations in nonsurvivors exceeded those in survivors on postburn day 5. The postburn alterations in heptachlor epoxide and oxychlordane concentrations could not be accounted for by changes in concentrations of circulating lipid. These findings, which indicate that xenoestrogens are released from fat depots after thermal injury, suggest a possible contribution to mortality, especially in older patients. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cassidy, RA (reprint author), 6160 St Joseph Cemetery Rd, Tell City, IN 47585 USA. EM rcassidy@dcci.com NR 51 TC 0 Z9 0 U1 0 U2 0 PU HELDREF PUBLICATIONS PI WASHINGTON PA 1319 EIGHTEENTH ST NW, WASHINGTON, DC 20036-1802 USA SN 0003-9896 J9 ARCH ENVIRON HEALTH JI Arch. Environ. Health PD SEP PY 2003 VL 58 IS 9 BP 597 EP 604 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 851MS UT WOS:000223689800009 PM 15369279 ER PT J AU Streever, WJ McKendrick, J Fanter, L Anderson, SC Kidd, J Portier, KM AF Streever, WJ McKendrick, J Fanter, L Anderson, SC Kidd, J Portier, KM TI Evaluation of percent cover requirements for revegetation of disturbed sites on Alaska's North Slope SO ARCTIC LA English DT Article DE Alaska; Arctic; North Slope; oil fields; percent cover; performance standards; rehabilitation; restoration; revegetation; tundra ID USA AB On the North Slope of Alaska, attempts have been made to revegetate areas damaged by development. Some revegetation projects strive to achieve specific performance standards based on percent vegetation cover. This study uses data, collected from 60 sites over 16 years to compare revegetating sites and natural reference sites. Results demonstrate that percent cover in most revegetation settings has the potential to reach levels comparable to those of reference sites, depending on how cover is defined. Linear models that explain between 48% and 84% of the variability in data show that planting cultivar seeds and fertilizing can increase cover (p < 0.05 for all models) and that cover continues to increase over time (p < 0.05 for all models), provided that cover is defined to include all live plants and plant litter. Ordination analysis separates reference sites from most revegetating sites along two significant axes (Monte Carlo tests, p < 0.01 with 100 randomizations). Comparison of ordination results with plots of change in plant cover over time shows that plant cover offers only limited insight into plant community development. If percent cover is to be used as a performance standard, it should be clearly defined, and the link between percent cover and restoration objectives should be carefully considered. Although this paper focuses on North Slope revegetation projects, the issues that are addressed have implications for all projects with performance standards calling for specific percent cover by vegetation. C1 BP Explorat Alaska Inc, Environm Studies Program, Anchorage, AK 99519 USA. USA, Waterways Expt Stn, Corps Engineers, Vicksburg, MS 39180 USA. Lazy Mt Res, Palmer, AK 99645 USA. USA, Corps Engineers, Anchorage, AK 99506 USA. ABR Inc, Environm Res & Serv, Fairbanks, AK 99708 USA. Univ Florida, Dept Stat, Inst Food & Agr Sci & Nat Resources, Gainesville, FL 32611 USA. RP Streever, WJ (reprint author), BP Explorat Alaska Inc, Environm Studies Program, POB 196612, Anchorage, AK 99519 USA. NR 34 TC 6 Z9 7 U1 1 U2 9 PU ARCTIC INST N AMER PI CALGARY PA UNIV OF CALGARY 2500 UNIVERSITY DRIVE NW 11TH FLOOR LIBRARY TOWER, CALGARY, ALBERTA T2N 1N4, CANADA SN 0004-0843 J9 ARCTIC JI Arctic PD SEP PY 2003 VL 56 IS 3 BP 234 EP 248 PG 15 WC Environmental Sciences; Geography, Physical SC Environmental Sciences & Ecology; Physical Geography GA 727VM UT WOS:000185681600003 ER PT J AU Burrell, L Durand, DB Fortado, J AF Burrell, L Durand, DB Fortado, J TI Military community integration and its effect on well-being and retention SO ARMED FORCES & SOCIETY LA English DT Article ID SOCIAL SUPPORT; LIFE STRESS AB This study examined psychosocial issues within Army families and the contribution of support networks to spouses' well-being and to their desire that their soldiers remain in the Army. Data from a self-administered questionnaire were analyzed for 137 spouses from the active duty component, 410 from the National Guard, and 174 from the reserve. Differences among the three groups were found with regard to both the composition of their social support networks as well as their use of such networks. Use of support was associated with well-being, but not with retention. C1 USARIEM, WAMC, Med Res Facil, Ft Bragg, NC 28310 USA. RP Burrell, L (reprint author), USARIEM, WAMC, Med Res Facil, MCXC-R Burrell,Bldg 4-2817 WAMC, Ft Bragg, NC 28310 USA. NR 14 TC 16 Z9 16 U1 0 U2 4 PU TRANSACTION PERIOD CONSORTIUM PI PISCATAWAY PA RUTGERS UNIV, DEPT 8010, 35 BERRUE CIRCLE, PISCATAWAY, NJ 08854-8042 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 2003 VL 30 IS 1 BP 7 EP + DI 10.1177/0095327X0303000101 PG 19 WC Political Science; Sociology SC Government & Law; Sociology GA 807JQ UT WOS:000220498200001 ER PT J AU Kolditz, T AF Kolditz, T TI The US Army War College: Military education in a democracy. SO ARMED FORCES & SOCIETY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Kolditz, T (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI PISCATAWAY PA RUTGERS UNIV, DEPT 8010, 35 BERRUE CIRCLE, PISCATAWAY, NJ 08854-8042 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD FAL PY 2003 VL 30 IS 1 BP 172 EP 175 PG 4 WC Political Science; Sociology SC Government & Law; Sociology GA 807JQ UT WOS:000220498200013 ER PT J AU Bruner, TL Schneider, RI James, JA Dennis, GJ Harley, JB AF Bruner, TL Schneider, RI James, JA Dennis, GJ Harley, JB TI Anti-C1q antibodies often occur before diagnosis and are associated with lupus nephritis in a large cohort of SLE patient SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 31 BP S60 EP S60 PG 1 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432800076 ER PT J AU Elliott, MR Tolnay, M Tsokos, GC Kammer, GM AF Elliott, MR Tolnay, M Tsokos, GC Kammer, GM TI Interaction of protein kinase a RIIbeta-subunit and CREB correlates with suppression of CREB transcriptional activity in activated T cells SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Wake Forest Univ, Winston Salem, NC 27109 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 1029 BP S415 EP S415 PG 1 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432801073 ER PT J AU Heinlen, LD McClain, MT Dennis, GJ Rubertone, MV Harley, JB James, JA AF Heinlen, LD McClain, MT Dennis, GJ Rubertone, MV Harley, JB James, JA TI The development of antibodies targeting Epstein-Barr virus closely parallels autoimmune progression near the onset of SLE. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Oklahoma Med Res Fdn, Oklahoma City, OK USA. Walter Reed Army Med Ctr, Washington, DC USA. US Army Ctr Hlth Promot & Prevent Med, Washington, DC USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 1733 BP S662 EP S663 PG 2 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432801774 ER PT J AU Krishnan, S Nambiar, MP Warke, VG Koenig, M Mitchell, J Tsokos, GC AF Krishnan, S Nambiar, MP Warke, VG Koenig, M Mitchell, J Tsokos, GC TI Altered lipid-raft composition and dynamics mediate abnormal T cell responses in systemic lupus erythematosus. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Uniformed Serv Univ Hlth Sci, Walter Reed Army Inst Res, Silver Spring, MD USA. Uniformed Serv Univ Hlth Sci, Walter Reed Army Inst Res, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 413 BP S195 EP S195 PG 1 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432800457 ER PT J AU Kyttaris, VC Juang, YT Tenbrock, K Weinstein, A Tsokos, GC AF Kyttaris, VC Juang, YT Tenbrock, K Weinstein, A Tsokos, GC TI cfos downregulation by CREM in lupus T cells. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Washington Hosp Ctr, Washington, DC 20010 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 410 BP S194 EP S194 PG 1 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432800454 ER PT J AU McClain, MT Bruner, TL Rindler, RJ Dennis, GJ Harley, JB James, JA AF McClain, MT Bruner, TL Rindler, RJ Dennis, GJ Harley, JB James, JA TI Ribosomal P autoantibodies are commonly present years before the onset of SLE. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 1768 BP S675 EP S675 PG 1 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432801809 ER PT J AU McClain, MT Bruner, TL Dennis, GJ Harley, JB James, JA AF McClain, MT Bruner, TL Dennis, GJ Harley, JB James, JA TI The temporal relationship between the onset of anti-EBNA-1 and lupus autoimmunity supports a role for EBV in the development of SLE. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 1764 BP S674 EP S674 PG 1 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432801805 ER PT J AU McClain, MT Arbuckle, MR Dennis, GJ Rubertone, M Kim, X Harley, JB James, JA AF McClain, MT Arbuckle, MR Dennis, GJ Rubertone, M Kim, X Harley, JB James, JA TI Clinical symptoms of systemic lupus erythematosus are often present years before diagnosis and occur after the development of autoantibodies. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. HM Jackson Fdn, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 1510 BP S584 EP S585 PG 2 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432801552 ER PT J AU Parker, CT Rennie, TA Wallace, E AF Parker, CT Rennie, TA Wallace, E TI Functional assessment of active duty compared to civilians with fibromyalgia. SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 67th Annual Scientific Meeting of the American-College-of-Rheumatology/38th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 23-28, 2003 CL ORLANDO, FLORIDA C1 Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2003 VL 48 IS 9 SU S MA 1279 BP S504 EP S505 PG 2 WC Rheumatology SC Rheumatology GA 723LA UT WOS:000185432801322 ER PT J AU Svoboda, SJ Williams, DM Murphy, KP AF Svoboda, SJ Williams, DM Murphy, KP TI Hip arthroscopy for osteochondral loose body removal after a posterior hip dislocation SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article DE hip; arthroscopy; osteochondral loose body; hip dislocation ID FRACTURE-DISLOCATION; RETRIEVAL; BULLET AB We report on the application of hip arthroscopy to remove an osteochondral fragment created by a posterior hip dislocation. Preoperative and postoperative radiographs and computed tomography scans correlate with intraoperative arthroscopic photographs and are presented with this report. Arthroscopy allowed excellent visualization of the joint and facilitated straightforward removal of the fragment. We were able to avoid the larger incision required by an arthrotomy and decreased the patient's overall morbidity from this condition. C1 Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Orthopaed Surg Serv, Sports Med Serv, Washington, DC 20307 USA. RP Murphy, KP (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Orthopaed Surg Serv, Sports Med Serv, Washington, DC 20307 USA. NR 11 TC 20 Z9 20 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD SEP PY 2003 VL 19 IS 7 BP 777 EP 781 DI 10.1016/S0749-8063(03)00696-0 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 720DE UT WOS:000185245600014 PM 12966387 ER PT J AU Powell, JT AF Powell, JT TI The cases for and against manual volume dampers SO ASHRAE JOURNAL LA English DT Article AB Army Corps of Engineers' construction documents for a military hospital in Fort Bragg, N.C., show more than 2,000 manual volume dampers (MVDs) upstream of variable air volume boxes. However, the installation of these dampers became the subject of a dispute during construction. According to the subcontractor, the system was a "high-pressure" system, making MVDs detrimental to its operation. C1 USA, Corps Engineers, Savannah Dist, Savannah, GA USA. RP Powell, JT (reprint author), USA, Corps Engineers, Savannah Dist, Savannah, GA USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEATING REFRIGERATING AIR-CONDITIONING ENG, INC, PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2491 J9 ASHRAE J JI ASHRAE J. PD SEP PY 2003 VL 45 IS 9 BP 49 EP + PG 6 WC Thermodynamics; Construction & Building Technology; Engineering, Mechanical SC Thermodynamics; Construction & Building Technology; Engineering GA 720RG UT WOS:000185273300017 ER PT J AU Harris, MD Lincoln, AE Amoroso, PJ Stuck, B Sliney, D AF Harris, MD Lincoln, AE Amoroso, PJ Stuck, B Sliney, D TI Laser eye injuries in military occupations SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE laser; eye; injury; mechanisms; military AB Introduction: Lasers (light amplification by stimulated emission of radiation) play an important role in our world and their Use is increasing. They are powerful tools for good, but can also cause tragedy, especially in an aviation environment. Information about injuries associated with lasers is limited. This Study highlights several laser eye injuries in the U.S. military and discusses issues pertaining to them. Methods: We gathered data from the U.S. Army Safety Center, the U.S. Army Center for Health Promotion and Preventive Medicine, and the Walter Reed Army Institute of Research. This paper describes ten representative cases of laser eye injury that occurred in the U.S. military between 1984 and 2000. Results: Patients suffered retinal damage, though no corneal injury occurred. Most were caused by accidental exposure to a Q-switched, Neodyium:YAG (Nd:YAG) laser at 1064 nm wavelength. The incidents occurred both on and off duty, indoors and outdoors, and from close and long ranges. None of the victims were wearing eye protection. Inadequate training and poor equipment design were major factors in at least six of the nine unintentional cases. The tenth occurred during military operations in the Persian Gulf. All of the victims needed several months medical care and follow up. Two received medical discharges as a result of their injuries. Discussion: As illustrated by these cases, human and societal costs from unintentional laser eye injuries can be reduced by improving operator training, safety procedure compliance, and equipment design. In addition, intentional laser eye injuries are a growing concern and further research is needed to design appropriate protection, treatment and countermeasures. C1 USA, Inst Environm Med, Natick, MA 01760 USA. RP Lincoln, AE (reprint author), Vet Adm Med Ctr, War Related Illness & Injury Study Ctr, MS 11,50 Irving St,NW, Washington, DC 20422 USA. FU NIOSH CDC HHS [R01 OH03703-01A1]; ODCDC CDC HHS [T42CCT310419] NR 13 TC 11 Z9 15 U1 2 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2003 VL 74 IS 9 BP 947 EP 952 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 719DT UT WOS:000185188900004 PM 14503672 ER PT J AU DeGroot, DW Devine, JA Fulco, CS AF DeGroot, DW Devine, JA Fulco, CS TI Incidence of adverse reactions from 23,000 exposures to simulated terrestrial altitudes up to 8900 m SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE hypobaric chamber training; decompression sickness; ear block; sinus block; barotrauma ID OPERATION EVEREST-II; PHYSIOLOGICAL INCIDENTS AB introduction: Adverse reactions during hypobaric chamber operations result from changes in barometric pressure per se and to the related reductions in the partial pressure of inspired oxygen. Previous studies have indicated that an adverse reaction may occur in similar to6% of exposures in chambers used for flight training. The purpose of this study was to determine the rate of adverse reactions in a chamber used exclusively for terrestrial altitude research studies. Methods: Data for incidence of ear block, sinus block, toothache, and other adverse reactions were analyzed using a master history file that contained information such as annual and total number of studies and human exposures, and onset and outcome of adverse reactions. Incidence for a given time period was calculated as (# of reactions X 100)/(# of exposures). Results: In 33 yr, there have been 23,656 human exposures and 296 adverse reactions. The overall incidence was 1.25 reactions per 100 exposures (0.72 for research volunteers and 0.53 for staff). The majority (75% of all reactions) were ear blocks (0.93 reactions per 100 exposures). Staff members were more likely than research volunteers to have more than one reaction. Discussion: The incidence of 1.25 reactions per 100 exposures for our chamber is considerably lower than that reported in the literature. This is due primarily to our use of lower altitudes and slower rates of ascent and descent compared with other facilities whose emphasis is on aircraft flight training. C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Fulco, CS (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, 42 Kansas St, Natick, MA 01760 USA. RI DeGroot, David/E-2322-2015 NR 8 TC 4 Z9 5 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2003 VL 74 IS 9 BP 994 EP 997 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 719DT UT WOS:000185188900013 PM 14503681 ER PT J AU Ozakman, M Schaad, NW AF Ozakman, M Schaad, NW TI A real-time BIO-PCR assay for detection of Ralstonia solanacearum race 3, biovar 2, in asymptomatic potato tubers SO CANADIAN JOURNAL OF PLANT PATHOLOGY-REVUE CANADIENNE DE PHYTOPATHOLOGIE LA English DT Article DE brown rot of potato; molecular identification; bacteria; geranium ID POLYMERASE-CHAIN-REACTION; PSEUDOMONAS-SOLANACEARUM; DISEASE AB Ralstonia solanacearum, the causal agent of brown rot of potato, can often be carried latently in seed potato tubers. We designed real-time PCR (polymerase chain reaction) primers and probe and a highly sensitive BIO-PCR assay for specific detection of the strains of race 3, biovar (bv.) 2 of R. solanacearum in asymptomatic potato tubers. The biovar-specific primers and probe reacted with all 17 strains of bv. 2 of R, solanacearum tested, including 12 from potato and 5 from geranium. None of the other 35 strains of R. solanacearum reacted, including 4 strains of bv. I from potato or the closely related blood disease bacterium from banana. None of 13 other bacteria reacted, including 5 Erwinia and 2 Clavibacter species from potato. Using undiluted potato tuber extract, inoculated with R. solanacearum bv. 2, as few as 30 cells/mL of extract could be detected. Two of 14 naturally infected potato tubers with no disease symptoms were positive by the newly described real-time BIO-PCR assay, whereas none were positive with a standard real-time PCR assay. This is the first report of the detection of R. solanacearum bv. 2 in asymptomatic, latently infected potato tubers by PCR. The real-time assay is very simple and much less time consuming than classical PCR. C1 USA, Agr Res Serv, Foreign Dis Weed Sci Res Unit, Ft Detrick, MD 21702 USA. Plant Protect Cent Res Inst, TR-06172 Ankara, Turkey. RP Schaad, NW (reprint author), USA, Agr Res Serv, Foreign Dis Weed Sci Res Unit, 1301 Ditto Ave, Ft Detrick, MD 21702 USA. NR 33 TC 28 Z9 34 U1 0 U2 7 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA, ONTARIO K1A 0R6, CANADA SN 0706-0661 J9 CAN J PLANT PATHOL JI Can. J. Plant Pathol.-Rev. Can. Phytopathol. PD SEP PY 2003 VL 25 IS 3 BP 232 EP 239 PG 8 WC Plant Sciences SC Plant Sciences GA 734VY UT WOS:000186079700002 ER PT J AU Jatoi, I Becher, H Leake, CR AF Jatoi, I Becher, H Leake, CR TI Widening disparity in survival between white and African-American patients with breast carcinoma treated in the U. S. Department of Defense healthcare system SO CANCER LA English DT Article DE breast carcinoma; survival; racial disparity; African American ID RACIAL-DIFFERENCES; CANCER SURVIVAL; WOMEN; RACE; POPULATION; PROGNOSIS; MORTALITY; INCREASES; OUTCOMES; THERAPY AB BACKGROUND. in the U.S., age-adjusted breast carcinoma mortality rates among white and African-American women have been diverging during the last 20 years. Some investigators speculate that the widening disparity is due to inequalities in access to healthcare, with African Americans having less access to necessary healthcare and improved therapies. Others argue that differences in tumor biology or some extrinsic influences on cancer etiology and behavior may account for the widening disparity. To examine this issue further, the authors compared trends in survival among white and African-American women diagnosed with breast carcinoma in the U. S. Department of Defense (DoD), an equal access healthcare system. METHODS. The medical records of all women diagnosed with primary breast carcinoma between 1980-1999 were retrieved from the U. S. DoD Automated Central Tumor Registry (ACTUR). Variables selected for further analysis were date of diagnosis, date of birth, vital status and date of death if applicable, race (black, white, and others), and stage of tumor. Because the database does not contain causes of death, overall survival was investigated. The effect of year of diagnosis and race on overall survival was analyzed using the Cox proportional hazards model stratified by age at diagnosis (1-year age groups). Calculations were performed separately by disease stage for all stages combined and stratified by stage. Statistical analyses were performed using the statistical software package SAS. RESULTS. After deleting observations with missing or implausible information regarding patient age, gender, and follow-up time, the final dataset was comprised of 23,612 women with primary breast carcinoma. The survival of African-American women compared with white women demonstrated an increasing ratio with calendar period. Although the hazard ratio was 1.269 for women diagnosed with breast carcinoma during the calendar period 1980-1984, it increased to 1.849 for those diagnosed between 1995-1999, which is a ratio of 1.46. For this period, the interaction between race and period was found to be significant (P = 0.04). CONCLUSIONS. The results of the current study demonstrated that breast carcinoma survival rates among white and African-American patients, adjusted for age and stage, are diverging in the U. S. DoD healthcare system. Thus, inequalities in access to healthcare most likely are not solely responsible for the widening racial disparities in outcome reported among women diagnosed with breast carcinoma. (C) 2003 American Cancer Society. C1 USA Hosp, Dept Surg, Heidelberg, Germany. Univ Heidelberg, Sch Med, Dept Trop Hyg & Publ Hlth, Heidelberg, Germany. USA, Ctr Army Anal, Dept Resource Anal, Ft Belvoir, VA USA. RP Jatoi, I (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Blvd, Bethesda, MD 20814 USA. NR 31 TC 81 Z9 81 U1 1 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD SEP 1 PY 2003 VL 98 IS 5 BP 894 EP 899 DI 10.1002/cncr.11604 PG 6 WC Oncology SC Oncology GA 714RV UT WOS:000184928000003 PM 12942554 ER PT J AU Ellsworth, RE Ellsworth, DL Lubert, SM Hooke, J Somiari, RI Shriver, CD AF Ellsworth, RE Ellsworth, DL Lubert, SM Hooke, J Somiari, RI Shriver, CD TI High-throughput loss of heterozygosity mapping in 26 commonly deleted regions in breast cancer SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID CAPILLARY ARRAY ELECTROPHORESIS; PCR AB Capillary array electrophoresis and laser-assisted microdissection, which provide increased speed and accuracy in loss of heterozygosity studies, are often used independently in studying breast cancer; the successful coupling of these emerging technologies, however, must overcome technical problems, especially those related to the poor quality and quality of DNA typically retrieved from archival tumor samples. Here we present a panel of 52 microsatellite markers from 26 of the most commonly deleted regions in breast cancer. All markers have been optimized to robustly amplify DNA extracted from paraffin-embedded samples, represent informative (highly polymorphic) loci, and effectively detect chromosomal loss. In the 10 tumor samples (stage 0 to stage III) tested here, chromosomal loss was detected loss for every locus, and the degree of loss at the 26 commonly deleted regions ranged from 23% to 77%. This panel can be used to quickly detect genomic patterns of loss in large numbers of breast tumor samples and may provide both clinical information and molecular information regarding the underlying tumor suppressor genes. C1 Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. Walter Reed Army Med Ctr, Clin Brast Care Project, Washington, DC 20307 USA. RP Ellsworth, RE (reprint author), Windber Res Inst, Clin Breast Care Project, 600 Somerset Ave, Windber, PA 15963 USA. NR 11 TC 34 Z9 34 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI BIRMINGHAM PA PO BOX 11806, BIRMINGHAM, AL 35202 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD SEP PY 2003 VL 12 IS 9 BP 915 EP 919 PG 5 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 724BX UT WOS:000185467900016 PM 14504204 ER PT J AU Kelly, C AF Kelly, C TI Effective treatment of episodic cluster headache with Frovatriptan SO CEPHALALGIA LA English DT Meeting Abstract CT 11th Congress of the International-Headache-Society CY SEP 12-16, 2003 CL ROME, ITALY SP Int Headache Soc C1 Womack Army Med Ctr, Dept Neurol, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 0333-1024 J9 CEPHALALGIA JI Cephalalgia PD SEP PY 2003 VL 23 IS 7 BP 735 EP 735 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 717XA UT WOS:000185115000575 ER PT J AU Shorr, AF Davies, DB Nathan, SD AF Shorr, AF Davies, DB Nathan, SD TI Predicting mortality in patients with sarcoidosis awaiting lung transplantation SO CHEST LA English DT Article DE lung transplantation; mortality; pulmonary hypertension; race; sarcoidosis ID IDIOPATHIC PULMONARY FIBROSIS; RENAL-TRANSPLANTATION; AFRICAN-AMERICANS; SURVIVAL; OUTCOMES; HYPERTENSION/; MODEL AB Objectives: To identify factors associated with mortality in patients with sarcoidosis listed for lung transplantation, and to create a model for predicting intermediate-term mortality in these individuals. Design: Retrospective cohort study of patients with sarcoidosis listed for lung transplant in the United States between 1995 and 2000. After identifying important risk factors for death, we developed a mortality prediction model based on an inception cohort of 75% of the subjects. The remaining 25% of the individuals served as a validation cohort for determining the validity of the model. Setting and patients: All patients with sarcoidosis in the United States irrespective of referral,center listed for lung transplantation between 1995 and 2000. Measurements and main results: Adequate follow-up data were available for 405 patients, and I I I patients (27.4%) died while awaiting lung transplantation. Neither patient age nor gender correlated with mortality. Survivors and nonsurvivors did not differ based on the results of spirometric testing. African Americans faced a significantly increased risk of death, which persisted after controlling for other confounders (odds ratio, 2.5). The amount of supplemental oxygen used and the mean pulmonary artery pressure were the only other variables predictive of mortality. The mean (+/- SD) pulmonary artery pressure in those who survived was 31.7 +/- 11.5 mm Hg, compared to 41.4 +/- 14.4 mm Hg in nonsurvivors (p < 0.01). Survivors required 2.2 +/- 2.0 L/min of oxygen vs 2.9 +/- 1.7 L/min in those who died awaiting transplant (p < 0.01). Differences in pulmonary artery pressures did not reflect differences in cardiac status, as the pulmonary capillary wedge pressure and the cardiac index were similar in survivors and nonsurvivors. The final mortality prediction model included three variables: race, amount of supplemental oxygen needed, and mean pulmonary artery pressure. Based on the validation cohort, the concordance of the model for death within 2 years of listing was 0.61 (95% confidence interval, 0.47 to 0.76), indicating only moderate explanatory power. Conclusions: Race, pulmonary hypertension, and oxygen use are important factors indicative of mortality in this population. Specific guidelines for determining time of referral for transplantation in advanced sarcoidosis should he developed. Recommendations extrapolated from data for other types of interstitial lung disease may not be applicable in sarcoidosis. The independent effect of race on outcome is troubling. C1 Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. Inova Fairfax Transplant Ctr, Fairfax, VA USA. United Network Organ Sharing, Richmond, VA USA. RP Shorr, AF (reprint author), Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 31 TC 112 Z9 113 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD SEP PY 2003 VL 124 IS 3 BP 922 EP 928 DI 10.1378/chest.124.3.922 PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 721XQ UT WOS:000185344100026 PM 12970018 ER PT J AU Bowery, CR AF Bowery, CR TI Mosby's fighting parson: The life and times of Sam Chapman SO CIVIL WAR HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Bowery, CR (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD SEP PY 2003 VL 49 IS 3 BP 297 EP 299 DI 10.1353/cwh.2003.0050 PG 3 WC History SC History GA 717DQ UT WOS:000185070700016 ER PT J AU Jayashankar, L Brasky, KM Ward, JA Attanasio, R AF Jayashankar, L Brasky, KM Ward, JA Attanasio, R TI Lymphocyte modulation in a baboon model of immunosenescence SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID NONHUMAN PRIMATE MODEL; REGION HEAVY-CHAINS; B-CELL REPERTOIRE; INFLUENZAE TYPE-B; IMMUNE-RESPONSE; CD28 EXPRESSION; T-LYMPHOCYTES; AGE; VACCINE; INTERLEUKIN-2 AB The age-related modulation of lymphocyte number and function was assessed in a nonhuman primate model consisting of healthy olive baboons (Papio cynocephalus anubis) of ages encompassing the entire life span of this species. The objectives of this study were to characterize an animal model of immunosenescence and to assess whether or not age should be considered when designing studies for the evaluation of vaccine candidates in baboons. Specifically the following parameters were assessed in baboons from 6 months to 26 years of age: relative numbers of B lymphocytes, CD4(+) and CD8(+) T lymphocytes, and T lymphocytes expressing CD28, CD25, and phytohemagglutinin-stimulated lymphoproliferative activity; and concentrations of total immunoglobulin, soluble interleukin-2 receptor alpha, and soluble CD30 in serum. There was a statistically significant effect of age on lymphocyte numbers. As age increased, relative B-cell numbers (ranging from 6 to 50%) decreased (P < 0.001) and relative T-cell numbers (ranging from 28 to 80%) increased (P < 0.001). The increase in T-cell numbers involved both the CD4(+) and CD8(+) subsets. In addition, there was a significant negative correlation of age with levels of soluble interleukin-2 receptor alpha in serum. Modulation of lymphocyte numbers appears to occur gradually during the entire baboon life span, thus suggesting the presence of an age-related developmentally regulated process. These findings indicate that baboons represent a potentially useful model to study selected phenomena related to immunosenescence. These findings also indicate that, when using the baboon model for vaccine or other experimental protocols requiring the assessment of immune responses, it would be appropriate to take into account the age of the animals in the study design. C1 Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA. Georgia State Univ, Inst Gerontol, Atlanta, GA 30303 USA. SW Fdn Biomed Res, Dept Lab Anim Med, San Antonio, TX 78245 USA. Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Attanasio, R (reprint author), Georgia State Univ, Dept Biol, MSC8L0389,33 Gilmer St,SE,Unit 8, Atlanta, GA 30303 USA. EM rattanasio@gsu.edu FU NCRR NIH HHS [R29 RR010755, RR10755] NR 43 TC 10 Z9 10 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD SEP PY 2003 VL 10 IS 5 BP 870 EP 875 DI 10.1128/CDLI.10.5.870-875.2003 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 722NQ UT WOS:000185383000024 PM 12965919 ER PT J AU Thompson, DB Burton, B Watters, M Belden, C Emery, RL Beall, DP AF Thompson, DB Burton, B Watters, M Belden, C Emery, RL Beall, DP TI Calcific cerebral arterial embolization in the setting of bacterial endocarditis superimposed on prior rheumatic aortic valvular disease SO CLINICAL IMAGING LA English DT Article DE calcific cerebral embolus; stroke; endocarditis; aortic valvular disease ID COMPUTED-TOMOGRAPHY; STENOSIS; EMBOLUS; STROKE; CT AB Stroke from a calcific cerebral artery embolus demonstrated by noncontrast computed tomography (CT) is rare. Although the ability of CT to demonstrate early acute cerebral emboli is limited, in the uncommon event of a calcific cerebral embolus, CT can easily visualize the embolized material. We present an unusual case of calcific cerebral arterial embolization to the proximal middle cerebral artery and illustrate the usefulness of CT in diagnosing this rare entity in conjunction with important predisposing clinical factors. (C) 2003 Elsevier Inc. All rights reserved. C1 Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol & Nucl Med, Bethesda, MD 20814 USA. RP Thompson, DB (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Rodger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0899-7071 J9 CLIN IMAG JI Clin. Imaging PD SEP-OCT PY 2003 VL 27 IS 5 BP 304 EP 306 DI 10.1016/S0899-7071(02)00564-8 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 716WU UT WOS:000185053200003 PM 12932679 ER PT J AU Fleming, SD Mastellos, D Karpel-Massler, G Shea-Donohue, T Lambris, JD Tsokos, GC AF Fleming, SD Mastellos, D Karpel-Massler, G Shea-Donohue, T Lambris, JD Tsokos, GC TI C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury SO CLINICAL IMMUNOLOGY LA English DT Article DE complement; neutrophils; inflammation; rodent; mucosa; adhesion molecules ID ISCHEMIA-REPERFUSION INJURY; REMOTE ORGAN INJURY; RECEPTOR ANTAGONIST; ENDOTHELIAL-CELLS; ALPHA(4) INTEGRIN; HUMAN NEUTROPHILS; MICE DEFICIENT; IN-VITRO; COMPLEMENT; INHIBITION AB C5 is critical in the development of local mucosal damage and inflammation as well as in the development of remote organ injury after mesenteric ischemia/reperfusion (IR). To define the role of C5a in tissue injury, we treated wild-type mice with a cyclic hexapeptide C5a receptor antagonist (C5aRa) and administered recombinant C5a to C5 deficient (C5(-/-)) mice subjected to mesenteric IR. We demonstrate that at 2-h postreperfusion, C5a administered to C5(-/-) mice during IR induces limited intestinal mucosal injury but failed to cause remote lung injury despite the fact that it upregulated adhesion molecule expression. C5aRa treatment of C5+/+ mice undergoing IR limited local injury and prevented distant organ injury. We conclude that although C5a can trigger certain components of the IR induced injury, other mediators such as C5b-9 and local factors are needed for the complete expression of IR tissue damage. (C) 2003 Elsevier Inc. All rights reserved. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Univ Penn, Sch Med, Dept Lab Med & Pathol, Philadelphia, PA 19104 USA. USDA ARS, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA. RP Fleming, SD (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Room 1A32,Bldg 503,Robert Grant Rd, Silver Spring, MD 20910 USA. OI Lambris, John/0000-0002-9370-5776 FU NIAID NIH HHS [AI49316]; NIGMS NIH HHS [R01-GM62134] NR 44 TC 43 Z9 45 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD SEP PY 2003 VL 108 IS 3 BP 263 EP 273 DI 10.1016/S1521-6616(03)00160-8 PG 11 WC Immunology SC Immunology GA 724BW UT WOS:000185467800012 PM 14499250 ER PT J AU Dainty, LA Winter, WE Maxwell, GL AF Dainty, LA Winter, WE Maxwell, GL TI The clinical behavior of placental site trophoblastic tumor and contemporary methods of management SO CLINICAL OBSTETRICS AND GYNECOLOGY LA English DT Article ID CHEMOTHERAPY; DISEASE; EXPERIENCE; REMISSION; PREGNANCY C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. RP Maxwell, GL (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 20 TC 9 Z9 10 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-9201 J9 CLIN OBSTET GYNECOL JI Clin. Obstet. Gynecol. PD SEP PY 2003 VL 46 IS 3 BP 607 EP 611 DI 10.1097/00003081-200309000-00011 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 725MU UT WOS:000185547600009 PM 12972741 ER PT J AU Zubier, K Panchang, V Demirbilek, Z AF Zubier, K Panchang, V Demirbilek, Z TI Simulation of waves at duck (North Carolina) using two numerical models SO COASTAL ENGINEERING JOURNAL LA English DT Article DE waves; model; SWAN; CGWAVE; FRF; pier; pilings; validation ID COASTAL REGIONS; BREAKING WAVES; BEACH; PROPAGATION; VALIDATION; EVOLUTION; SPECTRA; WATER AB Two wave transformation models, SWAN and CGWAVE, are used to simulate wave conditions at the Field Research Facility, Duck (North Carolina). The motivation is to examine how well these models reproduce observations and to determine the level of consistency between the two models. Stationary wave conditions pertaining to three different storm-induced bathymetric representations are modelled. It was found that SWAN and CGWAVE reproduced the observed wave behavior to a large extent, but CGWAVE results tended to be somewhat smaller than the SWAN results and the measurements. The differences were attributed to wave-wave interactions and breaking. Otherwise the models showed a high level of consistency. SWAN and CGWAVE were also used to explore other mechanisms reported in recent literature; the results were either consistent with some observations (in the case of the nonlinear mechanisms) or they shed more light on others (in case of the role of the research pier legs). C1 King Abdulaziz Univ, Fac Marine Sci, Jeddah 21589, Saudi Arabia. Texas A&M Univ, Dept Maritime Syst Engn, Galveston, TX 77553 USA. USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Panchang, V (reprint author), King Abdulaziz Univ, Fac Marine Sci, POB 80207, Jeddah 21589, Saudi Arabia. NR 37 TC 24 Z9 24 U1 0 U2 7 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA JOURNAL DEPT PO BOX 128 FARRER ROAD, SINGAPORE 912805, SINGAPORE SN 0578-5634 J9 COAST ENG J JI Coast Eng. J. PD SEP PY 2003 VL 45 IS 3 BP 439 EP 469 DI 10.1142/S0578563403000853 PG 31 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 727ZQ UT WOS:000185691100006 ER PT J AU Schiavetta, AM Harre, JG Wagner, E Simmons, M Raviprakash, K AF Schiavetta, AM Harre, JG Wagner, E Simmons, M Raviprakash, K TI Variable susceptibility of the owl monkey (Aotus nancymae) to four serotypes of dengue virus SO CONTEMPORARY TOPICS IN LABORATORY ANIMAL SCIENCE LA English DT Article ID EXPERIMENTAL-INFECTION; IMMUNE-RESPONSES; WORLD MONKEYS; VACCINE; TRIVIRGATUS; PROTECTION; HEMATOLOGY; ANTIBODIES; FEVER AB The goal of this study was to determine, for each of four dengue serotypes, whether owl monkeys (Aotus nancymae) become viremic and develop antibody responses in patterns similar to those seen in humans and whether any behavioral parameters are reliably associated with immunologic responses. A secondary goal was to investigate effects of chronic blood sampling on hematologic parameters in this genus. We inoculated 20 owl monkeys with 2 x 10(4) plaque-forming units of one of four dengue serotypes. Blood samples ranging from 0.4 to 0.7 ml per animal were taken each day for 12 consecutive days after inoculation, as well as on days 21, 28, and 60 post-inoculation. The total amount of blood taken per monkey was 8.0 ml during the first 12 days and 9.5 ml during the first 30 days of the study (i.e., up to 17% total blood volume per week and up to 20% total blood volume per month). Detailed behavioral assessments of all animals were made twice daily on every day of sample collection. The dengue-1 group were viremic for an average of 3.75 days. Dengue-2, -3, and 4 groups had average viremias of 1.00, 1.25, and 1.33 days, respectively. All animals demonstrated appropriate antibody responses as determined by enzyme-linked immunosorbency assay (ELISA). Animals tolerated repeated phlebotomy well, as all animals remained within clinically normal hematocrit (HCT) reference ranges, and no lasting effects on HCT occurred in any monkey. Final HCT for most animals was greater than 45% (mean final hematocrit, 45%). The maximum decrease in HCT ranged from 3.5 to 19 (mean, 8.9) percentage points. No consistent correlation of any behavioral disease parameters with viremia and antibody status was demonstrated, although overt illness did occur in two animals. Aotus can be an affordable and safe model for testing dengue vaccine efficacy; further testing with higher doses of dengue-2, -3 and 4 viruses is warranted. C1 USN, Walter Reed Army Inst Res, Med Res Ctr, Silver Spring, MD 20910 USA. RP Schiavetta, AM (reprint author), USN, Walter Reed Army Inst Res, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 32 TC 17 Z9 17 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1060-0558 J9 CONTEMP TOP LAB ANIM JI Contemp. Top. Lab. Anim. Sci. PD SEP PY 2003 VL 42 IS 5 BP 12 EP 20 PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 728CU UT WOS:000185698300003 PM 14510518 ER PT J AU Helman, DL Sherner, JH Fitzpatrick, TM Callender, ME Shorr, AF AF Helman, DL Sherner, JH Fitzpatrick, TM Callender, ME Shorr, AF TI Effect of standardized orders and provider education on head-of-bed positioning in mechanically ventilated patients SO CRITICAL CARE MEDICINE LA English DT Article DE ventilator-associated pneumonia; bed positioning; aspiration; semirecumbent; standardized order sets ID NOSOCOMIAL PNEUMONIA; PULMONARY ASPIRATION; BODY POSITION; PREVENTION; OROPHARYNGEAL; TRIAL; FLORA; RISK AB Objective: Semirecumbent head-of-bed positioning in mechanically ventilated patients decreases the risk of developing ventilator-associated pneumonia (VAP). The purpose of this study was to determine whether the addition of a standardized order followed by the initiation of a provider education program would increase the frequency with which our patients were maintained in the semirecumbent position. Design: Prospective, pre-, and postintervention observational study. Setting: A tertiary care, U.S. Army teaching hospital. Patients: Mechanically ventilated medical and surgical intensive care unit patients. Interventions: The first intervention involved the addition of an order for semirecumbent head-of-bed positioning to our intensive care unit order sets. This was followed 2 months later with a second intervention, which was a nurse and physician education program emphasizing semirecumbent positioning. Measurements and Main Results: Data regarding head-of-bed positioning were collected on 100 patient observations at baseline and at 1 and 2 months after each of our interventions. The mean angle of head of bed increased from 24 +/- 9 degrees at baseline to 35 +/- 9 degrees (p <.05) 2 months after the addition of the standard order. The percentage of observations with head of bed >45 degrees increased from 3% to 16% 2 months after the standardized order (P <.05). Two months after our provider education program, the mean angle of the head of bed was 34 +/- 11 degrees and the percentage of patents with head of bed >45 degrees was 29% (p = NS compared with values after the first intervention). Data collected 6 months after completion of our education programs showed that these improvements were maintained. Conclusions: Standardizing the process of care via the addition of an order specifying head-of-bed position significantly increased the number of patients who were placed in the semirecumbent position. In an era of cost-conscious medicine, interventions that utilize protocols and education programs should be emphasized. C1 Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Gen Internal Med Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Crit Care Nursing, Washington, DC 20307 USA. RP Helman, DL (reprint author), Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. NR 22 TC 41 Z9 44 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD SEP PY 2003 VL 31 IS 9 BP 2285 EP 2290 DI 10.1097/01.CCM.0000079609.81180.15 PG 6 WC Critical Care Medicine SC General & Internal Medicine GA 721BL UT WOS:000185297100005 PM 14501958 ER PT J AU Scobell, A AF Scobell, A TI China and North Korea: The limits of influence SO CURRENT HISTORY LA English DT Article C1 USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. RP Scobell, A (reprint author), USA, War Coll, Strateg Studies Inst, Carlisle, PA USA. NR 0 TC 6 Z9 6 U1 0 U2 7 PU CURRENT HIST INC PI PHILADELPHIA PA 4225 MAIN ST PO BOX 4647, PHILADELPHIA, PA 19127 USA SN 0011-3530 J9 CURR HIST JI Curr. Hist. PD SEP PY 2003 VL 102 IS 665 BP 274 EP 278 PG 5 WC International Relations; Political Science SC International Relations; Government & Law GA 714QC UT WOS:000184924100007 ER PT J AU Tsokos, GC Mitchell, JP Juang, YT AF Tsokos, GC Mitchell, JP Juang, YT TI T cell abnormalities in human and mouse lupus: intrinsic and extrinsic SO CURRENT OPINION IN RHEUMATOLOGY LA English DT Review ID RECEPTOR ZETA-CHAIN; PROTEIN-KINASE-A; MRL-LPR/LPR MICE; ERYTHEMATOSUS PATIENTS; MRL-FAS(LPR) MICE; MITOCHONDRIAL HYPERPOLARIZATION; DISEASE-ACTIVITY; UP-REGULATION; PRONE MICE; B-CELL AB The purpose of this review is to discuss recent developments in the biology and biochemistry of the T cells in mice and humans with systemic lupus erythematosus. T cells that recognize self-antigens are present in systemic lupus erythematosus and normal organisms. It is obvious, though, that an autoimmune environment should be present to disrupt anergy and instigate a response that might cause disease. The environment that lifts anergy is defined by distinct molecular aberrations that include rewiring of the T cells. Aberrant transcription of genes that encode proteins involved in autoimmunity can be traced to abnormal expression and activation of transcription factors and promoter methylation intensity. Only certain components of the autoimmune response can be linked to pathologic changes in the target organ that might be dictated by additional local factors. The works reviewed imply that self-peptides might be considered to reestablish lost tolerance, whereas correction of the aberrant biochemistry might normalize T cell function and limit disease. (C) 2003 Lippincott Williams Wilkins. C1 WRAIR, Dept Cellular Injury, Silver Spring, MD 20906 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Tsokos, GC (reprint author), WRAIR, Dept Cellular Injury, 503 Robert Grant Ave,Bldg 503,Rm 1A32, Silver Spring, MD 20906 USA. FU NIAID NIH HHS [R01 AI 49954, R01 AI42269, R01 AI42782] NR 59 TC 24 Z9 27 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-8711 J9 CURR OPIN RHEUMATOL JI CURR. OPIN. RHEUMATOL. PD SEP PY 2003 VL 15 IS 5 BP 542 EP 547 DI 10.1097/00002281-200309000-00004 PG 6 WC Rheumatology SC Rheumatology GA 715PB UT WOS:000184980000004 PM 12960478 ER PT J AU LeRoith, D Smith, DO AF LeRoith, D Smith, DO TI Loss of glucose homoeostasis: implications of basal glycaemia in type 2 diabetes SO DIABETES OBESITY & METABOLISM LA English DT Review DE glucose homoeostasis; glycaemic control; insulin glargine; insulin; type 2 diabetes ID FASTING PLASMA-GLUCOSE; LONG-TERM INSTABILITY; INSULIN-SECRETION; POSTPRANDIAL HYPERGLYCEMIA; CARDIOVASCULAR-DISEASE; NONDIABETIC SUBJECTS; ORAL-AGENTS; NPH INSULIN; MELLITUS; NIDDM C1 NIH, Diabet Branch, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Inst Diabet, Serv Endocrinol, Washington, DC 20307 USA. RP LeRoith, D (reprint author), NIH, Diabet Branch, NIH MSC 1758,Room 8D12,Bldg 10, Bethesda, MD 20892 USA. NR 77 TC 1 Z9 1 U1 0 U2 5 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 1462-8902 J9 DIABETES OBES METAB JI Diabetes Obes. Metab. PD SEP PY 2003 VL 5 IS 5 BP 285 EP 294 DI 10.1046/j.1463-1326.2003.00278.x PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 717WB UT WOS:000185112800004 PM 12940865 ER PT J AU Sisk, CM Parker, C Cassidy, T Parker, A AF Sisk, CM Parker, C Cassidy, T Parker, A TI Systemic vasculitis presenting with acute gastrointestinal hemorrhage - Case report and review of the literature SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE gastrointestinal; vasculitis; hemorrhage ID PULSE CYCLOPHOSPHAMIDE C1 Brooke Army Med Ctr, Dept Gastroenterol, San Antonio, TX USA. Brooke Army Med Ctr, Dept Rheumatol, San Antonio, TX USA. RP Sisk, CM (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU KLUWER ACADEMIC/PLENUM PUBL PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD SEP PY 2003 VL 48 IS 9 BP 1782 EP 1785 DI 10.1023/A:1025407414774 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 716BK UT WOS:000185008800021 PM 14561001 ER PT J AU Halstead, JM Michaud, J Hallas-Burt, S Gibbs, JP AF Halstead, JM Michaud, J Hallas-Burt, S Gibbs, JP TI Hedonic analysis of effects of a nonnative invader (Myriophyllum heterophyllum) on New Hampshire (USA) lakefront properties SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE variable milfoil; hedonics; nonnative species ID URBAN AIR-QUALITY; FUNCTIONAL FORM; IMPLICIT MARKETS; PRICE FUNCTIONS; WATER-QUALITY; CHOICE; VALUATION; BENEFITS; MODELS AB Introduced species are a major threat to the planet's ecosystems and one of the major causes of species extinction. This study deals with some of the economic impacts of one of these "invaders," variable milfoil. Variable milfoil can clog water-bodies, cause boating and swimming hazards, and crowd out native species. This study analyzed the effects of variable milfoil on shoreline property values at selected New Hampshire lakes. Results indicate that property values on lakes experiencing milfoil infestation may be considerably lower than similar properties on uninfested lakes. Results are highly sensitive to specification (variable selection) of the hedonic equation. C1 Univ New Hampshire, Dept Resource Econ & Dev, Durham, NH 03824 USA. USA, Corps Engineers, Ft Worth, TX USA. RP Halstead, JM (reprint author), Univ New Hampshire, Dept Resource Econ & Dev, Durham, NH 03824 USA. NR 33 TC 20 Z9 22 U1 1 U2 15 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD SEP PY 2003 VL 32 IS 3 BP 391 EP 398 DI 10.1007/s00267-003-3023-5 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 746PQ UT WOS:000186755100009 PM 14753624 ER PT J AU Landau, ME Cannard, KR AF Landau, ME Cannard, KR TI EEG characteristics in juvenile Huntington's disease: a case report and review of the literature SO EPILEPTIC DISORDERS LA English DT Review DE epilepsy; Huntington's disease; electroencephalography; myoclonus ID WAVE COMPLEXES; CHOREA; EPILEPSY; NEURONS; COMPONENTS; SEIZURES; ONSET AB The clinical features of Juvenile Huntington's Disease (J-HD) differ from those of the more common adult-onset form, and include cognitive decline, parkinsonism, myoclonus and seizures. A paucity of literature is available describing the electroencephalographic (EEG) findings. We describe the clinical and EEG characteristics of a patient with genetically confirmed J-HD. A review of previously published cases yielded EEG descriptions in only 23 patients whose disease onset was prior to the age of 32, and only 14 of these were prior to the age of 20. Epileptiform abnormalities were noted in 17 (74%), which was considerably more common than in the adult form. Generalized discharges were noted in nine, with six having polyspike and wave. The remainder had focal or multifocal epileptiform discharges. With genetic testing now available, refinement of the EEG data will be possible. C1 Walter Reed Army Med Ctr, Movement Disorder Sect, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Neurophysiol Sect, Washington, DC 20307 USA. RP Landau, ME (reprint author), 6109 Tilghman Dr, Laurel, MD 20707 USA. NR 20 TC 14 Z9 14 U1 0 U2 1 PU JOHN LIBBEY EUROTEXT LTD PI MONTROUGE PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE SN 1294-9361 J9 EPILEPTIC DISORD JI Epileptic Disord. PD SEP PY 2003 VL 5 IS 3 BP 145 EP 148 PG 4 WC Clinical Neurology SC Neurosciences & Neurology GA 746EU UT WOS:000186734700004 PM 14684349 ER PT J AU Gordon, RK Ginalski, K Rudnicki, WR Rychlewski, L Pankaskie, MC Bujnicki, JM Chiang, PK AF Gordon, RK Ginalski, K Rudnicki, WR Rychlewski, L Pankaskie, MC Bujnicki, JM Chiang, PK TI Anti-HIV-1 activity of 3-deaza-adenosine analogs - Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners SO EUROPEAN JOURNAL OF BIOCHEMISTRY LA English DT Article DE HIV-1; 3-deaza-adenosine; S-adenosylhomocysteine hydrolase inibitors; antiviral agents; modeling ID HUMAN-IMMUNODEFICIENCY-VIRUS; SITE-DIRECTED MUTAGENESIS; L-HOMOCYSTEINE HYDROLASE; ALKYL FUNCTIONAL-GROUP; II FORCE-FIELDS; CRYSTAL-STRUCTURE; NEPLANOCIN-A; ADENOSYLMETHIONINE SYNTHETASE; 3-DEAZAADENOSINE ANALOGS; CARBOCYCLIC ANALOG AB Eight adenosine analogs, 3-deaza-adenosine (DZA), 3-deaza-(+/-)aristeromycin (DZAri), 2',3'-dideoxy-adenosine (ddAdo), 2',3'-dideoxy-3-deaza-adenosine (ddDZA), 2',3'-dideoxy-3-deaza-(+/-)aristeromycin (ddDZAri), 3-deaza-5'-(+/-)noraristeromycin (DZNAri), 3-deaza-neplanocin A (DZNep), and neplanocin A (NepA), were tested as inhibitors of human placenta S-adenosylhomocysteine (AdoHcy) hydrolase. The order of potency for the inhibition of human placental AdoHcy hydrolase was: DZNep approximate to NePA >> DZAri approximate to DZNAri > DZA >> ddAdo approximate to ddDZA approximate to ddDZAri. These same analogs were examined for their anti-HIV-1 activities measured by the reduction in p24 antigen produced by 3'-azido-3'-deoxythymidine (AZT)-sensitive HIV-1 isolates, A012 and A018, in phytohemagglutinin-stimulated peripheral blood mononuclear (PBMCs) cells. Interestingly, DZNAri and the 2',3'-dideoxy 3-deaza-nucleosides (ddAdo, ddDZAri, and ddDZA) were only marginal inhibitors of p24 antigen production in HIV-1 infected PBMC. DZNAri is unique because it is the only DZA analog with a deleted methylene group that precludes anabolic phosphorylation. In contrast, the other analogs were potent inhibitors of p24 antigen production by both HIV-1 isolates. Thus it was postulated that these nucleoside analogs could exert their antiviral effect via a combination of anabolically generated nucleotides (with the exception of DZNAri), which could inhibit reverse transcriptase or other viral enzymes, and the inhibition of viral or cellular methylation reactions. Additionally, QSAR-like models based on the molecular mechanics (MM) were developed to predict the order of potency of eight adenosine analogs for the inhibition of human AdoHcy hydrolase. In view of the potent antiviral activities of the DZA analogs, this approach provides a promising tool for designing and screening of more potent AdoHcy hydrolase inhibitors and antiviral agents. C1 Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. Interdisciplinary Ctr Math & Computat Modelling, Warsaw, Poland. Bioinfobank Inst, Poznan, Poland. Palm Beach Atlantic Univ, Sch Pharm, W Palm Beach, FL USA. Int Inst Mol & Cell Biol, Bioinformat Lab, Warsaw, Poland. RP Ginalski, K (reprint author), Univ Texas, SW Med Ctr, Dept Biochem, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. RI Rudnicki, Witold/B-6670-2012 OI Rudnicki, Witold/0000-0002-7928-4944 NR 54 TC 41 Z9 41 U1 2 U2 7 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 0014-2956 J9 EUR J BIOCHEM JI Eur. J. Biochem. PD SEP PY 2003 VL 270 IS 17 BP 3507 EP 3517 DI 10.1046/j.1432-1033.2003.03726.x PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 722HU UT WOS:000185370000004 PM 12919315 ER PT J AU Alvero, RJ McKeeby, J Segars, J Miller, BT Nieman, L Armstrong, AY AF Alvero, RJ McKeeby, J Segars, J Miller, BT Nieman, L Armstrong, AY TI Reducing the risk and economic impact of High Order Multiple (HOM) gestations by the use of blastocysts at the time of embryo transfer. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 11-15, 2003 CL SAN ANTONIO, TEXAS SP Amer Soc Reprod Med C1 Univ Colorado, Hlth Sci Ctr, Aurora, CO USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NIH, Bethesda, MD 20892 USA. Reprod Assoc New Jersey, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2003 VL 80 SU 3 MA P176 BP S180 EP S181 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 727RM UT WOS:000185672400487 ER PT J AU Catherino, WH Klipstein, S McKeeby, J Segars, JH AF Catherino, WH Klipstein, S McKeeby, J Segars, JH TI Clomid citrate challenge test identifies more poor responders than day 3 FSH in patients over 35 years. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 11-15, 2003 CL SAN ANTONIO, TEXAS SP Amer Soc Reprod Med C1 NIH, Bethesda, MD 20892 USA. Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA. Walter Reed Army Med Ctr, ART Program, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2003 VL 80 SU 3 MA P111 BP S158 EP S158 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 727RM UT WOS:000185672400421 ER PT J AU Luterzo, J Parker, J Armstrong, A Alvero, R AF Luterzo, J Parker, J Armstrong, A Alvero, R TI A curriculum and performance assessment tool for saline sonohysterography. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 11-15, 2003 CL SAN ANTONIO, TEXAS SP Amer Soc Reprod Med C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NIH, Bethesda, MD 20892 USA. Univ Colorado, Hlth Sci Ctr, Aurora, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2003 VL 80 SU 3 MA O218 BP S83 EP S84 PG 2 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 727RM UT WOS:000185672400219 ER PT J AU Neithardt, AB Murdock, CM Segars, JH McKeeby, JL AF Neithardt, AB Murdock, CM Segars, JH McKeeby, JL TI Pre-embryo transfer sham at the time of embryo transfer improves clinical pregnancy rates. SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 11-15, 2003 CL SAN ANTONIO, TEXAS SP Amer Soc Reprod Med C1 NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2003 VL 80 SU 3 MA O249 BP S95 EP S95 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 727RM UT WOS:000185672400250 ER PT J AU Parker, JD Leondires, MP Segars, JH McKeeby, JL AF Parker, JD Leondires, MP Segars, JH McKeeby, JL TI Ovarian suppression with oral contraceptive pills prior to ART: Can you get too much of a "good" thing? SO FERTILITY AND STERILITY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Society-for-Reproductive-Medicine CY OCT 11-15, 2003 CL SAN ANTONIO, TEXAS SP Amer Soc Reprod Med C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Ctr Adv Reprod Med, Norwalk, CT USA. NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 2003 VL 80 SU 3 MA O286 BP S110 EP S110 PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 727RM UT WOS:000185672400287 ER PT J AU Jull, AJT Lal, D McHargue, LR Vacher, L Taylor, S Maurette, M AF Jull, AJT Lal, D McHargue, LR Vacher, L Taylor, S Maurette, M TI C-14 and Be-10 in cosmic dust magnetite SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 13th Annual VM Goldschmidt Conference CY SEP 07-12, 2003 CL KURASHIKI, JAPAN ID MICROMETEORITES; COLLECTION; ICE C1 Univ Arizona, NSF Arizona AMS Lab, Tucson, AZ 85721 USA. Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Ctr Spectrometrie Nucl & Spectrometrie Masse, IN2P3, F-91405 Orsay, France. NR 4 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD SEP PY 2003 VL 67 IS 18 SU 1 BP A192 EP A192 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 724ZF UT WOS:000185517600377 ER PT J AU Sjogren, M AF Sjogren, M TI Immunization and the decline of viral hepatitis as a cause of acute liver failure SO HEPATOLOGY LA English DT Editorial Material ID COST-EFFECTIVENESS; UNITED-STATES; FULMINANT-HEPATITIS; A VACCINATION; EXPERIENCE; INFECTION; ETIOLOGY; CHILDREN; EPIDEMIC; ADULTS C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Sjogren, M (reprint author), Walter Reed Army Med Ctr, 6825 16th NW Room 4023,Bldg 6, Washington, DC 20307 USA. NR 22 TC 7 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD SEP PY 2003 VL 38 IS 3 BP 554 EP 556 DI 10.1053/jhep.2003.50401 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 717JH UT WOS:000185085000003 PM 12939580 ER PT J AU Yeh, M Merlo, JL Wickens, CD Brandenburg, DL AF Yeh, M Merlo, JL Wickens, CD Brandenburg, DL TI Head up versus head down: The costs of imprecision, unreliability, and visual clutter on cue effectiveness for display signaling SO HUMAN FACTORS LA English DT Article ID AUTOMATION; ATTENTION; ALLOCATION; TRUST; PERFORMANCE; INFORMATION; INTENSITY; PROXIMITY; LOCATION; DESIGN AB We conducted 2 experiments to investigate the clutter-scan trade-off between the cost of increasing clutter by overlaying complex information onto the forward field of view using a helmet-mounted display (HMD) and the cost of scanning when presenting this information on a handheld display. In the first experiment, this trade-off was examined in terms of the spatial accuracy of target cuing data in a relatively sparse display; in the second, the spatial accuracy of the cue was varied more radically in an information-rich display. Participants were asked to detect and identify targets hidden in the far domain while performing a monitoring task in the near domain using either an HMD or a handheld display. The results revealed that on a sparse display, the reduced scanning from the HMD presentation of cuing outweighed the costs of clutter for cued targets, regardless of cue precision, but no benefit was found for uncued targets. When the HMD displayed task-irrelevant information, however, target detection was hindered by the extraneous clutter in the forward field of view relative to the handheld display condition, and this cost of clutter increased as the amount of data that needed to be inspected increased. Potential applications of this research include the development of design considerations for head-up displays for aviation and military applications. C1 Univ Illinois, Inst Aviat, Aviat Res Lab, Savoy, IL 61874 USA. US Mil Acad, West Point, NY 10996 USA. RP Wickens, CD (reprint author), Univ Illinois, Inst Aviat, Aviat Res Lab, Willard Airport,1 Airport Rd, Savoy, IL 61874 USA. EM cwickens@s.psych.uiuc.edu NR 32 TC 36 Z9 38 U1 1 U2 10 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD FAL PY 2003 VL 45 IS 3 BP 390 EP 407 DI 10.1518/hfes.45.3.390.27249 PG 18 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 751DU UT WOS:000187038200004 PM 14702991 ER PT J AU Alvero, R Hearns-Stokes, RM Catherino, WH Leondires, MP Segars, JH AF Alvero, R Hearns-Stokes, RM Catherino, WH Leondires, MP Segars, JH TI The presence of blood in the transfer catheter negatively influences outcome at embryo transfer SO HUMAN REPRODUCTION LA English DT Article DE blood; embryo transfer technique; implantation; pregnancy rate; retained embryos ID IN-VITRO FERTILIZATION; ASSISTED-REPRODUCTIVE-TECHNOLOGY; PREGNANCY RATES; INVITRO FERTILIZATION; ULTRASOUND GUIDANCE; MULTIPLE ATTEMPTS; MORPHOLOGY; PROGRAM; TRIAL AB BACKGROUND: Embryo transfer (ET) influences pregnancy rates in patients undergoing assisted reproduction. Data are conflicting as to which variables affect ET success. This study examines variables that may affect outcome after ET in assisted reproductive technology patients who had high-quality embryos transferred. METHODS: Over a 23 month period, 669 consecutive cycles were examined. Only patients having grade I and grade II embryos, or blastocyst transfers, were included in this retrospective analysis. A total of 584 consecutive cycles met study criteria. At the time of ET, the following variables were recorded: aborted first attempt at ET; presence of blood and/or mucus in or on the transfer catheter after ET; ease of ET as judged by provider; need for mock embryo transfer immediately before the actual transfer and retention of embryos in the transfer catheter. These variables were retrospectively analysed for their impact on implantation rate (IR) and clinical pregnancy rate (CPR). RESULTS: There were 290 gestations (49.7% CPR). Multiple attempts at ET, subjective difficulty of ET, performance of a sham pass immediately prior to embryo transfer, and presence of mucus on or in the catheter did not affect the CPR or IR. No difference was noted in the mean age of patients having or lacking any of these factors. There was a significant association between the presence of blood on or in the catheter and decreased IR (P = 0.015) and CPR (P = 0.004). Retained embryos also decreased IR (P = 0.03). Multivariable analysis confirmed that the presence of blood on the transfer catheter was the most important of these transfer characteristics in predicting IR (P = 0.042) and CPR (P = 0.018). CONCLUSIONS: These results suggest that when only high-grade embryos or blastocysts are transferred, the presence of blood on the catheter is associated with decreased IR and CPR in assisted reproduction. C1 Univ Colorado, Hlth Sci Ctr, Aurora, CO 80010 USA. Walter Reed Army Med Ctr, Washington, DC 20003 USA. NICHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA. RP Alvero, R (reprint author), Univ Colorado, Hlth Sci Ctr, Anschutz Outpatient Pavil,1635 N Ursula St,Mail S, Aurora, CO 80010 USA. NR 29 TC 34 Z9 35 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0268-1161 J9 HUM REPROD JI Hum. Reprod. PD SEP PY 2003 VL 18 IS 9 BP 1848 EP 1852 DI 10.1093/humrep/deg359 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 721NA UT WOS:000185321400015 PM 12923137 ER PT J AU Kennedy, RH Tundisi, JG Straskrabova, V Lind, OT Hejzlar, J AF Kennedy, RH Tundisi, JG Straskrabova, V Lind, OT Hejzlar, J TI Reservoirs and the limnologist's growing role in sustainable water resource management SO HYDROBIOLOGIA LA English DT Editorial Material C1 USA, Corps Engineers, European Res Off, London NW1 5TH, England. Int Inst Ecol, BR-13560460 Sao Carlos, SP, Brazil. Acad Sci Czech Republ, Inst Hydrobiol, Ceske Budejovice 37005, Czech Republic. Baylor Univ, Dept Biol, Limnol Lab, Waco, TX 76798 USA. RP Kennedy, RH (reprint author), USA, Corps Engineers, European Res Off, 223 Old Marylebone Rd, London NW1 5TH, England. RI Hejzlar, Josef/F-8526-2014; Straskrabova, Viera/H-8406-2014 NR 9 TC 8 Z9 9 U1 0 U2 6 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD SEP 1 PY 2003 VL 504 IS 1-3 BP XI EP XII PG 2 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 765XJ UT WOS:000188316100002 ER PT J AU Dempsey, PJ Handschuh, RF Afjeh, AA AF Dempsey, PJ Handschuh, RF Afjeh, AA TI Decision fusion analysis detects spiral bevel gear damage SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE LA English DT Article AB A diagnostic tool for detecting damage to spiral bevel gears was developed. Two different monitoring technologies - oil debris analysis and vibration - were integrated using data fusion into a health monitoring system for detecting surface fatigue pitting damage on gears. This integrated system showed improved detection and decision-making capabilities as compared to using individual monitoring technologies. This diagnostic tool was evaluated by collecting vibration and oil debris data from fatigue tests performed in the NASA Glenn Spiral Bevel Gear Fatigue Rigs. Data was collected during experiments performed in this test rig when pitting damage occurred. Results show that combining the vibration and oil debris measurement technologies improves the detection of pitting damage on spiral bevel gears. C1 NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. USA, Res Lab, Glenn Res Ctr, Cleveland, OH 44135 USA. Univ Toledo, Toledo, OH 43606 USA. RP Dempsey, PJ (reprint author), NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. NR 17 TC 2 Z9 2 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0885-8985 J9 IEEE AERO EL SYS MAG JI IEEE Aerosp. Electron. Syst. Mag. PD SEP PY 2003 VL 18 IS 9 BP 11 EP 17 DI 10.1109/MAES.2003.1232154 PG 7 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA 718DR UT WOS:000185130300002 ER PT J AU Osinski, M Smagley, VA Lu, M Smolyakov, GA Eliseev, PG Riely, BP Shen, PH Simonis, GJ AF Osinski, M Smagley, VA Lu, M Smolyakov, GA Eliseev, PG Riely, BP Shen, PH Simonis, GJ TI Self-consistent calculation of current self-distribution effect in GaAs-AlGaAs oxide-confined VCSELs SO IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS LA English DT Article DE semiconductor device modeling; semiconductor lasers; vertical cavity surface-emitting laser (VCSEL) ID SURFACE-EMITTING LASERS; EFFECTIVE FREQUENCY METHOD; SEMICONDUCTOR-LASERS; THERMAL-CONDUCTIVITY; NUMERICAL-SIMULATION; CARRIER LEAKAGE; DESIGN; MODEL AB A three-dimensional electrical-thermal-optical numerical solver is applied to model GaAs-AlGaAs-based top-emitting oxide-confined vertical-cavity surface-emitting lasers (VCSELs) with GaAs multiple-quantum-well active region. Continuous-wave mode of operation is simulated over a range of voltages, covering the subthreshold spontaneous emission and lasing emission. The effect of self-distribution of electrical current is demonstrated for the first time in self-consistent electrical-thermal-optical simulation of VCSELs. C1 Univ New Mexico, Ctr High Technol Mat, Albuquerque, NM 87106 USA. Russian Acad Sci, PN Lebedev Phys Inst, Moscow, Russia. USA, Res Lab, Adelphi, MD 20783 USA. RP Osinski, M (reprint author), Univ New Mexico, Ctr High Technol Mat, Albuquerque, NM 87106 USA. EM osinski@chtm.unm.edu; eliseev@chtm.unm.edu; briely@arl.army.mil NR 25 TC 16 Z9 16 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1077-260X J9 IEEE J SEL TOP QUANT JI IEEE J. Sel. Top. Quantum Electron. PD SEP-OCT PY 2003 VL 9 IS 5 BP 1422 EP 1430 DI 10.1109/JSTQE.2003.819507 PG 9 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 772TY UT WOS:000188858600044 ER PT J AU Liu, JJ Olver, KA Taysing-Lara, M Taylor, T Chang, W Horst, S AF Liu, JJ Olver, KA Taysing-Lara, M Taylor, T Chang, W Horst, S TI High-yield flip-chip bonding and packaging of low-threshold VCSEL arrays on sapphire substrates SO IEEE TRANSACTIONS ON COMPONENTS AND PACKAGING TECHNOLOGIES LA English DT Article DE flip-chip bonding; oxide aperture; PGA package; sapphire substrate; VCSEL ID OPTICAL INTERCONNECTS AB Oxide-confined top-emitting 850 nm and bottom-emitting 980 nm vertical-cavity surface-emitting laser (VCSEL) 8 x 8 arrays were designed and fabricated for applications of optical interconnects. The arrays were flip-chip bonded onto sapphire substrates that contain complimentary metal-oxide-semiconductor (CMOS) driver and fan-out circuitries. The off-sited bonding contacts and minimized bonding force produced very high yield of hybridization process without causing damage to the VCSEL mesas. The hybridized devices were further mounted either on printed circuit board (PCB) or in 68-pin pin-grid-array (PGA) packages. The transparent sapphire substrate allowed optical outputs from the top-emitting VCSEL arrays to transmit directly through without additional substrate removal procedure. Lasing thresholds below 250 muA for 850 nm VCSELs and 800 muA for 980 nm VCSEL were found at room temperature. The oxide confinement apertures of VCSELs were measured to be around 6 mum in diameter. High-speed data transmission demonstrated a bandwidth of up to 1 Gbits/s per channel for these hybridized VCSEL transmitters. C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. Lab Phys Sci, College Pk, MD 20742 USA. RP Liu, JJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. NR 11 TC 8 Z9 10 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1521-3331 J9 IEEE T COMPON PACK T JI IEEE Trans. Compon. Packaging Technol. PD SEP PY 2003 VL 26 IS 3 BP 548 EP 553 DI 10.1109/TCAPT.2003.817645 PG 6 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 729BY UT WOS:000185752200007 ER PT J AU Katsis, DC van Wyk, JD AF Katsis, DC van Wyk, JD TI Void-induced thermal impedance in power semiconductor modules: Some transient temperature effects SO IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS LA English DT Article; Proceedings Paper CT Annual Meeting of the Industry-Applications-Society CY SEP 30-OCT 05, 2001 CL CHICAGO, IL SP Ind Applicat Soc DE die-attach; power MOSFET; thermal impedance; thermal resistance ID DEVICES AB The operation of power semiconductor modules creates thermal stresses that grow voids in the solder die-attach layer. These voids reduce the ability of the die-attach solder layer to conduct heat from the silicon junction to the heat spreader. This results in increased thermal impedance. The effect of accelerated aging on solder bond voiding and on thermal transient behavior is investigated. Commercially packaged TO-247 style MOSFETs are power cycled, imaged, and thermally analyzed to generate a correlation between void percentage and thermal impedance. C1 Virginia Polytech Inst & State Univ, Ctr Power Elect Syst, Bradley Dept Elect & Comp Engn, Blacksburg, VA 24061 USA. RP Katsis, DC (reprint author), USA, Res Lab, AMSRL SE DP, Adelphi, MD 20783 USA. EM katsisdc@ieee.org; daan@vt.edu NR 16 TC 44 Z9 49 U1 2 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-9994 EI 1939-9367 J9 IEEE T IND APPL JI IEEE Trans. Ind. Appl. PD SEP-OCT PY 2003 VL 39 IS 5 BP 1239 EP 1246 DI 10.1109/TIA.2003.816527 PG 8 WC Engineering, Multidisciplinary; Engineering, Electrical & Electronic SC Engineering GA 725WQ UT WOS:000185565700001 ER PT J AU Zhu, XY Dogaru, T Carin, L AF Zhu, XY Dogaru, T Carin, L TI Analysis of the CDF biorthogonal MRTD method with application to PEC targets SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE numerical methods; time domain; wavelets ID PERFECTLY CONDUCTING OBJECTS; CONFORMAL FDTD ALGORITHM; TIME-DOMAIN ALGORITHM; MULTIRESOLUTION ANALYSIS; DIELECTRIC RESONATORS; SCATTERING; SCHEMES; SURFACES; WAVELETS; DISPERSION AB We consider the biorthogonal Cohen-Daubechies-Feauveau (CDF) wavelet family in the context of a biorthogonal multiresolution time-domain (bi-MRTD) analysis. A disadvantage of previous bi-MRTD analyses is an inability to handle abrupt changes in material properties, particularly for a perfect electric conductor (PEC). A multiregion method is proposed to address PEC targets. The proposed method is based on the fact that the CDF bi-MRTD may be viewed as a linear combination of several conventional finite-difference time-domain (FDTD) solutions. The implementation of the connecting surface is also simplified. Several numerical results are presented, with comparison to analytic and FDTD results. C1 Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Zhu, XY (reprint author), Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. NR 34 TC 6 Z9 8 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD SEP PY 2003 VL 51 IS 9 BP 2015 EP 2022 DI 10.1109/TMTT.2003.815874 PG 8 WC Engineering, Electrical & Electronic SC Engineering GA 712GH UT WOS:000184789400005 ER PT J AU Yang, JS Zhang, XS Kosinski, JA Pastore, RA AF Yang, JS Zhang, XS Kosinski, JA Pastore, RA TI Thickness-shear vibrations of a quartz plate under time-dependent biasing deformations SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID ELECTROELASTIC EQUATIONS; CRYSTAL-OSCILLATORS; ACCELERATION AB Incremental thickness-shear vibrations of a Y-cut quartz crystal plate under time-harmonic biasing extensional deformations are studied using the two-dimensional equations for small fields superposed on finite biasing fields in an electroelastic plate. It is shown that the incremental thickness-shear vibrations are governed by the well-known Mathieu's equation with a time-dependent coefficient. Both free and electrically forced vibrations are studied. Approximate analytical solutions are obtained when the frequency of the biasing deformation is much lower than that of the incremental thickness-shear vibration. The incremental thickness-shear free vibration mode is shown to be both frequency and amplitude modulated, with the frequency modulation as a first-order effect and the amplitude modulation a second-order effect. The forced vibration solutions show that both the static and motional capacitances become time-dependent due to the time-harmonic biasing deformations. C1 Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. USA, CECOM, Ft Monmouth, NJ 07703 USA. RP Yang, JS (reprint author), Univ Nebraska, Dept Engn Mech, Lincoln, NE 68588 USA. EM jyang@unl.edu NR 14 TC 3 Z9 3 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD SEP PY 2003 VL 50 IS 9 BP 1114 EP 1123 DI 10.1109/TUFFC.2003.1235323 PG 10 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 724ZX UT WOS:000185519100004 PM 14561028 ER PT J AU Yadava, A Ockenhouse, CF AF Yadava, A Ockenhouse, CF TI Effect of codon optimization on expression levels of a functionally folded malaria vaccine candidate in prokaryotic and eukaryotic expression systems SO INFECTION AND IMMUNITY LA English DT Article ID PLASMODIUM-FALCIPARUM EBA-175; APICAL MEMBRANE ANTIGEN-1; RECEPTOR-BINDING DOMAIN; PICHIA-PASTORIS; ANTIBODIES; PARASITES; INVASION; ERYTHROCYTES; PURIFICATION; PROTEIN-1 AB We have produced two synthetic genes that code for the F2 domain located within region II of the 175-kDa Plasmodium falciparum erythrocyte binding antigen (EBA-175) to determine the effects of codon alteration on protein expression in homologous and heterologous host systems. EBA-175 plays a key role in the process of merozoite invasion into erythrocytes through a specific receptor-ligand interaction. The F2 domain of EBA-175 is the ligand that binds to the glycophorin A receptor on human erythrocytes and is therefore a target of vaccine development efforts. We designed synthetic genes based on P. falciparum, Escherichia coli, and Pichia codon usage and expressed recombinant F2 in E. coli and Pichia pastoris. Compared to the expression of the native F2 sequence, conversion to prokaryote (E. coli)- or eukaryote (Pichia)-based codon usage dramatically improved the levels of recombinant protein expression in both E. coli and P. pastoris. The majority of the protein expressed in E. coli, however, was produced as inclusion bodies. The protein expressed in P. pastoris, on the other hand, was expressed as a secreted, soluble protein. The P. pastoris-produced protein was superior to that produced in E. coli based on its ability to bind to red blood cells. Consistent with these observations, the antibodies generated against the Pichia-produced protein prevented the binding of recombinant EBA to red blood cells. These antibodies recognize EBA-175 present on merozoites as well as in sporozoites by immunofluorescence. Our results suggest that the Pichia-based EBA-F2 vaccine construct has further potential to be developed for clinical use. C1 Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. RP Yadava, A (reprint author), Walter Reed Army Inst Res, Dept Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 32 TC 64 Z9 74 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 2003 VL 71 IS 9 BP 4961 EP 4969 DI 10.1128/IAI.71.9.4961-4969.2003 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 715WR UT WOS:000184996600017 PM 12933838 ER PT J AU Campbell, DJ Campbell, KM AF Campbell, DJ Campbell, KM TI Global versus facet predictors of intention to quit: differences in a sample of male and female Singaporean managers and non-managers SO INTERNATIONAL JOURNAL OF HUMAN RESOURCE MANAGEMENT LA English DT Article DE managerial turnover; non-managerial turnover; facet predictors of turnover; gender differences in turnover; intention to quit; Singaporean HRM ID VOLUNTARY EMPLOYEE TURNOVER; SELF-REPORTED AFFECT; ORGANIZATIONAL COMMITMENT; GENDER DIFFERENCES; JOB-SATISFACTION; FAMILY ROLES; WORK ORIENTATIONS; METHOD VARIANCE; SEX-DIFFERENCES; MODEL AB Prior research on gender and turnover has produced inconsistent findings. Some investigators have argued that the use of more highly focused job, work and organization facets can reveal patterns not captured by more global measures, and thus resolve some of these contradictory results. Using a sample of almost 1200 Singaporeans, the current study first examined the relationship between quit intentions and global measures of job satisfaction and organizational commitment, within each of four groups (male non-managers, male managers, female non-managers and female managers). As hypothesized, the global measures were highly and similarly correlated to an individual's intention to quit in all four groups, suggesting no gender/job-level effects. However, when we substituted a set of eleven specific facet measures in place of the two global measures, a unique facet pattern for each group emerged, as hypothesized. Discussion centred on some cautions in interpreting the research and the need for fully developed theoretical models to guide facet research. C1 US Mil Acad, Dept Behav Sci & Leadership, W Point, NY 10996 USA. RP Campbell, DJ (reprint author), US Mil Acad, Dept Behav Sci & Leadership, W Point, NY 10996 USA. NR 67 TC 15 Z9 18 U1 3 U2 11 PU ROUTLEDGE TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0958-5192 J9 INT J HUM RESOUR MAN JI Int. J. Hum. Resour. Manag. PD SEP PY 2003 VL 14 IS 7 BP 1152 EP 1177 DI 10.1080/0958519032000114246 PG 26 WC Management SC Business & Economics GA 724VC UT WOS:000185506500005 ER PT J AU Kellogg, KG Kallmeyer, AR Dutta, PK AF Kellogg, KG Kallmeyer, AR Dutta, PK TI Influence of moisture and reduced-temperature thermal cycles on the Izod notch toughness of a pultruded glass-fiber composite SO INTERNATIONAL JOURNAL OF OFFSHORE AND POLAR ENGINEERING LA English DT Article DE glass-fiber composite; Izod notch toughness; low temperature; moisture; thermal cycles ID EPOXY COMPOSITES; IMPACT BEHAVIOR AB An investigation was conducted into the effects of moisture, low temperatures and low-temperature thermal cycling on the notched Izod impact resistance of a pultruded, glass fiber-reinforced polymer composite. Impact tests were performed on composite specimens with a 90-degree V-notch resulting in a fracture surface parallel to the fiber direction. The test matrix consisted of 2 major groups, dry (as received) and wet (moisture conditioned), with each group independently tested to determine the influence of low temperatures and thermal cycling. The temperature effect was addressed by impacting several specimens at 25degrees, -5degrees, -25degrees and -50degreesC. The effect of thermal cycling was subsequently studied by impacting specimens after completion of 50, 150 and 300 cycles between 25degrees and -50degreesC. The findings reveal that moisture, temperature and low-temperature thermal cycling all influence the Izod impact toughness of the material system tested, although the effects were not always as anticipated. A summative review and discussion of previous work on the impact toughness of fiber-reinforced polymers is provided, and the results of the current test program are discussed within the context of the previous research. C1 N Dakota State Univ, Dept Civil Engn, Fargo, ND 58105 USA. N Dakota State Univ, Dept Mech Engn, Fargo, ND 58105 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Kellogg, KG (reprint author), N Dakota State Univ, Dept Civil Engn, Fargo, ND 58105 USA. NR 13 TC 4 Z9 4 U1 0 U2 1 PU INT SOC OFFSHORE POLAR ENGINEERS PI CUPERTINO PA PO BOX 189, CUPERTINO, CA 95015-0189 USA SN 1053-5381 J9 INT J OFFSHORE POLAR JI Int. J. Offshore Polar Eng. PD SEP PY 2003 VL 13 IS 3 BP 232 EP 239 PG 8 WC Engineering, Civil; Engineering, Ocean; Engineering, Mechanical SC Engineering GA 719YW UT WOS:000185233500011 ER PT J AU Holmquist, TJ Johnson, GR AF Holmquist, TJ Johnson, GR TI Modeling projectile impact onto prestressed ceramic targets SO JOURNAL DE PHYSIQUE IV LA English DT Article; Proceedings Paper CT 7th Internatioanl Conference on Mechanical and Physical Behaviour of Materials Under Dynamic Loading CY SEP 08-12, 2003 CL OPORTO, PORTUGAL AB This work presents computed results for the responses of ceramic targets, with and without prestress, subjected to projectile impact. Also presented is a computational technique to include prestress. Ceramic materials have been considered for armor applications for many years because of their high strength and low density. Many researchers have demonstrated that providing confinement enhances the ballistic performance of ceramic targets. More recently, prestressing the ceramic is being considered as an additional enhancement technique. This work investigates the effect of prestressing the ceramic for both thin and thick target configurations subjected to projectile impact. In all cases the targets with ceramic prestress provided enhanced ballistic performance. The computed results indicate that prestressed ceramic reduces and/or delays failure, resulting in improved ceramic performance and ballistic efficiency. C1 USA, High Performance Comp Res Ctr, Network Comp Serv Inc, Minneapolis, MN 55458 USA. RP Holmquist, TJ (reprint author), USA, High Performance Comp Res Ctr, Network Comp Serv Inc, POB 581459, Minneapolis, MN 55458 USA. NR 9 TC 9 Z9 10 U1 0 U2 2 PU E D P SCIENCES PI LES ULIS CEDEXA PA 7, AVE DU HOGGAR, PARC D ACTIVITES COURTABOEUF, BP 112, F-91944 LES ULIS CEDEXA, FRANCE SN 1155-4339 J9 J PHYS IV JI J. Phys. IV PD SEP PY 2003 VL 110 BP 597 EP 602 DI 10.1051/jp4:20030758 PG 6 WC Physics, Multidisciplinary SC Physics GA 725NZ UT WOS:000185550400099 ER PT J AU Dandekar, DP Reinhart, WD Chhabildas, LC AF Dandekar, DP Reinhart, WD Chhabildas, LC TI Reshock behavior of silicon carbide SO JOURNAL DE PHYSIQUE IV LA English DT Article; Proceedings Paper CT 7th Internatioanl Conference on Mechanical and Physical Behaviour of Materials Under Dynamic Loading CY SEP 08-12, 2003 CL OPORTO, PORTUGAL ID COMPRESSION; STRENGTH AB The shear strength of a ceramic is an important material property which is indicative of its behaviour under impact loading condition. The brittle nature of ceramics suggest that impact loading of a ceramic attained due to subsonic impact could change the initial shear strength of the ceramic. If so, the subsequent behaviour of the ceramic may not be dependent on the the initial strength. Thus, it is necessary to determine the shear strength of a cermaic under single and multiple impacts. The present work determines the change in the shear strength of silicon carbide under a single shock, shock-reshock, and shock-release wave propagation, respectively. The material used in this work is marketed by CERCOM Inc. as SiC-B. The results of this work indicate that shear strength of SiC-B increases under shock-reshock. C1 AMSRL WM TD, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. Sandia Natl Labs, Albuquerque, NM 87185 USA. RP Dandekar, DP (reprint author), AMSRL WM TD, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 13 TC 9 Z9 9 U1 1 U2 2 PU E D P SCIENCES PI LES ULIS CEDEXA PA 7, AVE DU HOGGAR, PARC D ACTIVITES COURTABOEUF, BP 112, F-91944 LES ULIS CEDEXA, FRANCE SN 1155-4339 J9 J PHYS IV JI J. Phys. IV PD SEP PY 2003 VL 110 BP 827 EP 831 DI 10.1051/jp4:20030796 PG 5 WC Physics, Multidisciplinary SC Physics GA 725NZ UT WOS:000185550400137 ER PT J AU Andreas, EL Fairall, CW Persson, POG Guest, PS AF Andreas, EL Fairall, CW Persson, POG Guest, PS TI Probability distributions for the inner scale and the refractive index structure parameter and their implications for flux averaging SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article ID ATMOSPHERIC SURFACE-LAYER; APERTURE SCINTILLOMETER TEST; SCINTILLATION MEASUREMENTS; OPTICAL PROPAGATION; SENSIBLE HEAT; ENERGY BUDGET; TEMPERATURE; SPECTRUM; MOMENTUM; OCEAN AB Defining the averaging time required for measuring meaningful turbulence statistics is a central problem in boundary layer meteorology. Path-averaging scintillation instruments are presumed to confer some time-averaging benefits when the objective is to measure surface fluxes, but that hypothesis has not been tested definitively. This study uses scintillometer measurements of the inner scale (iota(0)) and the refractive index structure parameter (C-n(2)) to investigate this question of required averaging time. The first conclusion is that the beta probability distribution is useful for representing C-n(2) and iota(0) measurements. Consequently, beta distributions are used to set confidence limits on C-n(2) and iota(0) values obtained over various averaging periods. When the C-n(2) and iota(0) time series are stationary, a short-term average of C-n(2) or iota(0) can be as accurate as a long-term average. However, as with point measurements, when time series of path averaged C-n(2) or iota(0) values are nonstationary, turbulent surface fluxes inferred from these C-n(2) and iota(0) values can be variable and uncertain-problems that path averaging was presumed to mitigate. Because nonstationarity is a limiting condition, the last topic is quantifying the nonstationarity with a published nonstationarity ratio and also by simply counting zero crossings in the time series. C1 USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. NOAA, Environm Technol Lab, Boulder, CO USA. Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. Naval Postgrad Sch, Monterey, CA USA. RP Andreas, EL (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. NR 58 TC 10 Z9 11 U1 0 U2 3 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD SEP PY 2003 VL 42 IS 9 BP 1316 EP 1329 DI 10.1175/1520-0450(2003)042<1316:PDFTIS>2.0.CO;2 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 717KR UT WOS:000185088100009 ER PT J AU Polyakov, AY Smirnov, NB Govorkov, AV Kozhukhova, EA Vdovin, VI Ip, K Overberg, ME Heo, YW Norton, DP Pearton, SJ Zavada, JM Dravin, VA AF Polyakov, AY Smirnov, NB Govorkov, AV Kozhukhova, EA Vdovin, VI Ip, K Overberg, ME Heo, YW Norton, DP Pearton, SJ Zavada, JM Dravin, VA TI Proton implantation effects on electrical and recombination properties of undoped ZnO SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PERSISTENT PHOTOCONDUCTIVITY; N-GAN; HYDROGEN; BOMBARDMENT; BAND AB Electrical and optical properties of undoped n-ZnO crystals implanted with 50 keV protons with doses from 5x10(13) to 5x10(15) cm(-2) are reported. Proton implantation leads to a decrease of the carrier concentration in the near-surface region, but at the end of the proton range shallow donors are observed whose concentration tracks the implant dose and that we attribute to hydrogen donors. Three deep electron traps with apparent activation energies of 0.55, 0.75, and 0.9 eV are introduced by proton implantation. The 0.9 eV traps have been observed through the increased thermal stability of the Schottky diodes prepared on heavily implanted n-ZnO compared to unimplanted or lightly implanted samples. In addition, hole traps located 0.16 eV above the valence band edge were introduced by implantation. Proton implantation also led to the formation of persistent-photocapacitance-active defects and to considerable decrease in the intensity of the band edge luminescence and in the value of the photocurrent of the Au/n-ZnO Schottky diodes. When compared with other wide-band gap materials, such as GaN, the recombination properties of n-ZnO are shown to be more resistant to deterioration upon proton implantation. (C) 2003 American Institute of Physics. C1 Inst Rare Met, Moscow 119017, Russia. Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. PN Lebedev Phys Inst, Moscow 117924, Russia. RP Pearton, SJ (reprint author), Inst Rare Met, B Tolmachevsky 5, Moscow 119017, Russia. RI Smirnov, Nickolai/K-8935-2015; Dravin, Valeri/M-7266-2015; Вдовин, Владимир/R-6595-2016 OI Smirnov, Nickolai/0000-0002-4993-0175; Вдовин, Владимир/0000-0002-0952-5335 NR 19 TC 63 Z9 63 U1 1 U2 17 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 2003 VL 94 IS 5 BP 2895 EP 2900 DI 10.1063/1.1597944 PG 6 WC Physics, Applied SC Physics GA 713EP UT WOS:000184844200015 ER PT J AU Polyakov, AY Smirnov, NB Govorkov, AV Pearton, SJ Zavada, JM AF Polyakov, AY Smirnov, NB Govorkov, AV Pearton, SJ Zavada, JM TI Proton implantation effects on electrical and luminescent properties of p-GaN SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID N-GAN; OPTICAL-PROPERTIES; FILMS; RECOMBINATION; BOMBARDMENT; TRAPS; BAND; MN; FE; CR AB The electrical properties, deep level spectra, and microcathodoluminescence (MCL) spectra of p-GaN films implanted with 100 keV protons are reported. Measurable decreases of the MCL intensity began for doses as low as 10(12) cm(-2), while measurable decreases of the hole concentration started for doses of 10(13) cm(-2). The main deep traps introduced by protons had activation energies of 0.3, 0.6, and 0.9 eV. The 0.3 and 0.9 eV traps are located in the lower half of the band gap and determine the temperature dependence of the forward current in heavily proton implanted Schottky diodes. (C) 2003 American Institute of Physics. C1 Inst Rare Met, Moscow 119017, Russia. Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Polyakov, AY (reprint author), Inst Rare Met, B Tolmachevsky 5, Moscow 119017, Russia. RI Smirnov, Nickolai/K-8935-2015 OI Smirnov, Nickolai/0000-0002-4993-0175 NR 23 TC 25 Z9 25 U1 1 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 2003 VL 94 IS 5 BP 3069 EP 3074 DI 10.1063/1.1600828 PG 6 WC Physics, Applied SC Physics GA 713EP UT WOS:000184844200041 ER PT J AU Nindl, BC Castellani, JW Young, AJ Patton, JF Khosravi, MJ Diamandi, A Montain, SJ AF Nindl, BC Castellani, JW Young, AJ Patton, JF Khosravi, MJ Diamandi, A Montain, SJ TI Differential responses of IGF-I molecular complexes to military operational field training SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE somatotropic hormones; nutritional status; binary concentrations; magnetic exclusion separation; fasting ID FACTOR-BINDING-PROTEINS; GROWTH-FACTOR-I; ACID-LABILE SUBUNIT; FACTOR (IGF)-BINDING PROTEINS; FACTOR SYSTEM; NUTRITIONAL REGULATION; SOMATOMEDIN-C; HORMONE; SERUM; HUMANS AB Insulin-like growth factor (IGF) I and IGF binding proteins (IGFBPs) modulate metabolic activity and tissue repair and are influenced by nutritional status. IGF-I circulates in free, ternary [IGF-I + IGFBP-3 + acid labile subunit (ALS)], and binary (IGF-I + IGFBP) molecular complexes, and the relative proportions regulate IGF-I extravascular shifting and bioavailability. This study examined the hypothesis that sustained physical activity and sleep deprivation superimposed on a short-term energy deficit would alter the IGFBP concentrations and alter the proportions of IGF-I circulating in ternary vs. binary molecular complexes. Components of the IGF-I system (total and free IGF-I; IGFBP-1, -3, and ALS; nonternary IGF-I and IGFBP-3), biomarkers of metabolic and nutritional status (transferrin, ferritin, prealbumin, glucose, free fatty acids, glycerol, beta-hydroxybutyrate), and body composition were measured in 12 men (22 +/- 3 yr, 87 +/- 8 kg, 183 +/- 7 cm, 20 +/- 5% body fat) on days 1, 3, and 4 during a control and experimental (Exp) period. During Exp, subjects performed prolonged work (energy expenditure of similar to4,500 kcal/day) with caloric (1,600 kcal/day) and sleep (6.2 h total) restriction. IGF-I and IGFBP-3 were measured by immunoassay before and after immunoaffinity depletion of ALS-based complexes (i.e., ternary complex removal). Exp produced losses in body mass (-3.0%), lowered total IGF-I (-24%), free IGF-I (-42%), IGFBP-3 (-6%), nonternary IGF-I (-27%), and IGFBP-3 (-16%), and increased IGFBP-1 (256%). No Exp effects were observed for ALS. No changes were observed in the proportion of IGF-I circulating in free (similar to1.2%), ternary (similar to87.4%), or nonternary (similar to11.4%) molecular complexes. During Exp, glucose concentrations were lower on day 3, but days 1 and 4 were statistically similar. In conclusion, during a short-term energy deficit in young, healthy men, 1) IGF-I system components differentially respond (both in direction and magnitude) to a given metabolic perturbation and 2) the relative proportion of IGF-I sequestered in ternary vs. nonternary molecular complexes appears to be well maintained. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. Diagnost Syst Labs Canada, Toronto, ON M5G 1X5, Canada. Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1X5, Canada. Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. NR 40 TC 31 Z9 31 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD SEP PY 2003 VL 95 IS 3 BP 1083 EP 1089 DI 10.1152/japplphysiol.01148.2002 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 711HP UT WOS:000184733800024 PM 12909598 ER PT J AU Dunn, WR Lincoln, AE Hinton, RY Smith, GS Amoroso, PJ AF Dunn, WR Lincoln, AE Hinton, RY Smith, GS Amoroso, PJ TI Occupational disability after hospitalization for the treatment of an injury of the anterior cruciate ligament SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID US ARMY PERSONNEL; TERM FOLLOW-UP; WORKERS-COMPENSATION; CIGARETTE-SMOKING; SURGICAL-TREATMENT; BACK-PAIN; RECONSTRUCTION; DISORDERS; OUTCOMES; MILITARY AB Background: To date, no large population-based studies have focused on permanent occupational disability after injury of the anterior cruciate ligament as far as we know. The purpose of our study was to determine the risk factors for occupational disability after an injury of the anterior cruciate ligament. Methods: We identified a cohort of 2192 active-duty personnel in the Army who had been hospitalized between 1989 and 1997 because of an injury of the anterior cruciate ligament and had completed a health risk-assessment survey. With use of the Total Army Injury and Health Outcomes Database, we retrospectively followed these individuals for up to nine years and collected clinical, demographic, occupational, and psychosocial data. These data were then evaluated with bivariate and proportional-hazards regression, analyses to identify risk factors for receiving a disability discharge related to an injury of the anterior cruciate ligament. Results: Overall, 209 (9.5%) of 2192 initial anterior cruciate ligament injuries resulted in a permanent disability discharge. In bivariate analyses, the following factors were related to a disability discharge: lower job satisfaction (p < 0.0001), lower education level (p < 0.0001), shorter length of service (p < 0.0001), lower pay grade or rank (p < 0.0001), occupational classification (p < 0.0001), older age (p < 0.01), cigarette-smoking (p = 0.01), and greater mental stress at work (p = 0.02). Associated cartilage injury (p = 0.07) and occupational physical demands (p = 0.08) approached significance; however, with the numbers available, other variables that were hypothesized to contribute to the development of disability, such as gender (p = 0.85), reconstruction of the anterior cruciate ligament (p = 0.52), and other secondary comorbidities of the knee, demonstrated no significant association. Proportional-hazards regression analysis confirmed that pay grade or rank, occupational classification, job satisfaction, age, and length of service were independent predictors of disability discharge. Conclusions: in keeping with risk profiles of several other musculoskeletal disorders, such as low-back pain and carpal tunnel syndrome, the results revealed a multifactorial risk profile in which psychosocial factors were strongly associated with disability discharge from active military duty after injury of the anterior cruciate ligament. Level of Evidence: Prognostic study, Level II-1 (retrospective study). See Instructions to Authors for a complete description of levels of evidence. C1 Hosp Special Surg, Sports Med & Shoulder Serv, New York, NY 10021 USA. Union Mem Hosp, Dept Orthopaed Surg, Baltimore, MD 21218 USA. War Related Illness & Injury Study Ctr, Washington, DC 20422 USA. Liberty Mutual Res Inst Safety, Hopkinton, MA 01748 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Injury Res & Policy, Dept Hlth Policy & Management, Baltimore, MD USA. Vet Affairs Med Ctr, Dept Vet Affairs, Washington, DC 20422 USA. RP Dunn, WR (reprint author), Hosp Special Surg, Sports Med & Shoulder Serv, 535 E 70th St, New York, NY 10021 USA. RI Duncan, Kirsty/H-1911-2011; OI Smith, Gordon/0000-0002-2911-3071 FU NIOSH CDC HHS [R01 OH03703-01A1] NR 55 TC 24 Z9 24 U1 1 U2 4 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD SEP PY 2003 VL 85A IS 9 BP 1656 EP 1666 PG 11 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 722XN UT WOS:000185403500002 PM 12954822 ER PT J AU Modi, J Patel, A Terrell, R Tuttle, RM Francis, GL AF Modi, J Patel, A Terrell, R Tuttle, RM Francis, GL TI Papillary thyroid carcinomas from young adults and children contain a mixture of lymphocytes SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID ENDOTHELIAL GROWTH-FACTOR; TUMOR-NECROSIS-FACTOR; GRAVES-DISEASE; FREE SURVIVAL; CANCER; EXPRESSION; CELLS; INFILTRATION; ADOLESCENTS; RECURRENCE AB The immune response appears to be important in preventing metastasis and recurrence of thyroid cancer. We previously showed that papillary thyroid carcinoma (PTC) from children and adolescents that contain the most numerous proliferating lymphocytes have the best prognosis. However, the types of lymphocytes involved are not yet known. To further define this, we examined 21 PTCs from patients 21 yr of age or younger (52% were 18-21 yr of age) for the presence of CD4+ (helper), CD8+ (killer), CD19+ (B cells), and CD56+ (natural killer) cells as well as proliferating lymphocytes (Ki-67+). Nearly half the PTCs contained CD4+ (9 of 21, 43%), CD8+ (8 of 21, 38%), or CD19+ (10 of 21, 48%) lymphocytes. Only one PTC (1 of 21, 5%) contained CD56+ lymphocytes, and none contained all four cell types. By dual staining, none of these lymphocytes were proliferating (Ki-67+). However, PTCs containing either CD8+ cells (n=8) or a combination of CD4+, CD8+, and CD19+ cells (n=5) contained more numerous proliferating lymphocytes than did PTCs containing any other combination (14.2-fold increase, P=0.03 and 13.1-fold increase, P=0.003, respectively). During follow-up, none of the PTCs containing either CD8+ lymphocytes or the combination of CD4+, CD8+, and CD19+ lymphocytes recurred. However, the cohort is too small and the follow-up inadequate to provide accurate information on the clinical impact of these immunological findings. We conclude that the immune response against PTC is important and also complex, involving more than one type of lymphocyte. C1 Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Mem Sloan Kettering Canc Ctr, Dept Endocrinol, New York, NY 10021 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. RP Francis, GL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM gfrancis@usuhs.mil NR 44 TC 25 Z9 28 U1 2 U2 4 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD SEP PY 2003 VL 88 IS 9 BP 4418 EP 4425 DI 10.1210/jc.2003-030342 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 720JY UT WOS:000185258700062 PM 12970319 ER PT J AU Zuzek, PJ Nairn, RB Thieme, SJ AF Zuzek, PJ Nairn, RB Thieme, SJ TI Spatial and temporal considerations for calculating shoreline change rates in the Great Lakes Basin SO JOURNAL OF COASTAL RESEARCH LA English DT Article; Proceedings Paper CT Shoreline Change Workshop CY MAY 07-09, 2002 CL CHARLESTON, SOUTH CAROLINA DE recession; bluff; dune; end point rate; linear regression ID PROTECTION STRUCTURES; RECESSION RATES; EROSION; ERIE; MICHIGAN; POSITIONS; ACCRETION; BLUFFS; LEVEL; TOE AB Accurate long-term shoreline change rates are required for a wide range of shoreline studies and coastal zone management applications in the Great Lakes Basin. However, the literature on methods, techniques for quantifying source errors, guidelines for data acquisition, and new approaches is focused primarily on the sandy coastlines of the eastern and gulf coasts of the United States. Therefore, a comprehensive shoreline change investigation was completed for Ottawa and Allegan Counties, Michigan to investigate issues specific to the fresh water shorelines of the Great Lakes. A detailed spatial database was developed that included 79 km of continuous top of bank and dune crest lines for five temporal periods. Over 70,000 erosion transects were generated and analyzed with customized ArcGIS tools for the sandy and cohesive shore types found in the two counties. Significant spatial and temporal variability in the transect measurements were observed for both shore types. Based on the results, a series of detailed recommendations are provided for selecting historical sources of positional data, minimizing sampling errors by selecting an appropriate transect spacing, considering lake level impacts, and the influence of the bluff failure cycle on recession rates. C1 WF Baird & Associates, Oakville, ON L6J 5Z7, Canada. USA Corps Engineers, Detroit, MI 48231 USA. RP Zuzek, PJ (reprint author), WF Baird & Associates, 627 Lyons Lane,Suite 200, Oakville, ON L6J 5Z7, Canada. NR 42 TC 6 Z9 7 U1 0 U2 4 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 2003 SI 38 BP 125 EP 146 PG 22 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 763VG UT WOS:000188120700009 ER PT J AU Stauble, DK AF Stauble, DK TI The use of shoreline change mapping in coastal engineering project assessment SO JOURNAL OF COASTAL RESEARCH LA English DT Article; Proceedings Paper CT Shoreline Change Workshop CY MAY 07-09, 2002 CL CHARLESTON, SOUTH CAROLINA DE National Shoreline Study 1971; NOAA/NOS-CERC Cooperative Shoreline; Movement Mapping Study; National Shoreline Management Study; inlet adjacent shoreline change; beach nourishment; hot spots; narrow-crested submerged breakwaters; coastal engineering AB An important tool in assessment of coastal engineering problems is the understanding of shoreline evolution. The U.S. Army Corps of Engineers is responsible for the safe navigation at inlets and coastal harbor entrances and providing shore protection projects to protect the coastal infrastructure from damage due to coastal storms. Shoreline change studies have been a useful tool in evaluating the success of these projects. On a national scale, several shoreline change studies have been done by the Corps to evaluate the erosion potential and identify areas of "critical erosion" on a national or regional scale. In 1971, the Corps published the National Shoreline Study to compile an analysis of the Nations shorelines and develop shore protection management guidelines. Areas of critical erosion were identified for future shore protection needs. In the 1980's, a joint NOAA-CERC cooperative shoreline movement study provided a series of long-term shoreline change maps of four coastal regions and analysis of selected shoreline change rates and patterns. A new National Shoreline Management Study is being initiated to pursue an interagency effort to update the study of coastal erosion and to improve future coastal sediment management issues. Information from the study will be used to develop recommendations regarding Federal and non-Federal participation in shore protection and use of a systems approach to sand management on a national scale. On a more local scale, shoreline change mapping has been applied to many coastal engineering projects to improve design and management of resources. Three selected projects are used to show tools and techniques from recent studies to evaluate shoreline trends on the project scale in both navigation and shore protection applications. The use of a Geographic Information System (GIS) has facilitated integration of various shoreline formats into a usable product. A complex evolution of a new inlet formation was evaluated using aerial photography derived shorelines to assess adjacent barrier island movements and resulting impacts to navigation channel management. Hot and Cold spots of erosion and accretion were identified and measured by shoreline change analysis along a beach nourishment project to improve renourishment design. A shoreline change analysis of an experimental nearshore prefabricated breakwater indicated a complex interaction of natural nearshore hardbottom and sand wave movement controlled shoreline change more than the breakwater. Shoreline change analysis has been carried out on the national and project specific scale. Each study has improved understanding of how shoreline evolution has changed with both natural and engineering practices and its relationship to coastal engineering problems. C1 USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Stauble, DK (reprint author), USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 31 TC 3 Z9 3 U1 0 U2 5 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 2003 SI 38 BP 178 EP 206 PG 29 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 763VG UT WOS:000188120700012 ER PT J AU Wozencraft, JM Lillycrop, WJ AF Wozencraft, JM Lillycrop, WJ TI SHOALS airborne coastal mapping: Past, present, and future SO JOURNAL OF COASTAL RESEARCH LA English DT Article; Proceedings Paper CT Shoreline Change Workshop CY MAY 07-09, 2002 CL CHARLESTON, SOUTH CAROLINA DE lidar; SHOALS; bathymetry; topography; aerial photography; hyperspectral imagery; remote sensing; shoreline monitoring; regional sediment management AB The US Army Corps of Engineers (USACE) SHOALS (Scanning Hydrographic Operational Airborne Lidar Survey) program has evolved from an inlets R&D effort to a fully operational and constantly developing airborne coastal mapping initiative. The data collected in eight years of SHOALS survey operations have improved understanding of the coastal processes that drive shoreline change at USACE navigation and shore protection projects. The knowledge and experience gained from eight years of SHOALS operations have paved the way for a generational advancement in airborne coastal mapping by identifying complementary data sets to SHOALS bathymetry and by pinpointing aspects of survey planning, data collection, and data processing that could be automated for a more easily operated system. The result is the Compact Hydrographic Airborne Rapid Total Survey (CHARTS) system. CHARTS is an integrated bathymetric/ topographic/digital imagery system currently under development for the US Naval Oceanographic Office. A bathymetric lidar component operates at a rate of 1,000 H, while a topographic lidar component operates at 10,000 Hz. Digital imagery will be collected using a georeferenced camera that can provide a visual backdrop for the soundings and elevations collected by the other components. CHARTS will easily deploy from most photogrammetric aircraft of opportunity and will incorporate highly automated algorithms based on current SHOALS processing methodology. CHARTS will be commercially available as SHOALS-1000 following field-testing in August 2003. System flight parameters and sensor suite are ideal for further integration with additional sensors such as a hyperspectral imager. SHOALS-1000 will initiate a new era of complete coastal mapping from an airborne platform. C1 USA Corps Engineers Mobile Dist, Joint Airborne Lidar Bathymetry Tech Ctr Expertis, Mobile, AL 36602 USA. RP Wozencraft, JM (reprint author), USA Corps Engineers Mobile Dist, Joint Airborne Lidar Bathymetry Tech Ctr Expertis, Mobile, AL 36602 USA. NR 12 TC 9 Z9 9 U1 0 U2 2 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 2003 SI 38 BP 207 EP 215 PG 9 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 763VG UT WOS:000188120700013 ER PT J AU Soibelman, L Liu, LY Kirby, JG East, EW Caldas, CH Lin, KY AF Soibelman, L Liu, LY Kirby, JG East, EW Caldas, CH Lin, KY TI Design review checking system with corporate lessons learned SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE LA English DT Review DE construction management; design; data collection; Internet AB Design reviews are critical to the success of a construction project. They eliminate costly rework and conflicts, and promote creative and innovative design and construction. This paper discusses a unique way to improve design reviews by gathering and including direct corporate experience that can be used company- and industry-wide. The Design Review Checking System (DrChecks) and the system called Corporate Lessons Learned (CLL) were developed by the U.S. Army Construction Engineering Research Laboratory to collect personal experiences and lessons learned on projects and incorporate these data into corporate knowledge, expressly for the design review process. DrChecks provides a framework for a standardized review process. Typically, exchanges of personal experience and knowledge have occurred informally by word of mouth. With DrChecks and CLL, direct personal experience can be collected into a database while the design review process is on-going. Lessons learned, success stories, and good work practices, which can be identified easily by experienced staff members, can then be shared throughout the organization. DrChecks and CLL both take advantage of the Internet and facilitate the management of design review process and the collection and reuse of corporate lessons learned asynchronously and remotely. C1 Univ Illinois, Dept Civil & Environm Engn, Newmark CE Lab 3129, Urbana, IL 61801 USA. Engn Proc Branch, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Soibelman, L (reprint author), Univ Illinois, Dept Civil & Environm Engn, Newmark CE Lab 3129, Urbana, IL 61801 USA. NR 19 TC 22 Z9 22 U1 0 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9364 J9 J CONSTR ENG M ASCE JI J. Constr. Eng. Manage.-ASCE PD SEP-OCT PY 2003 VL 129 IS 5 BP 475 EP 484 DI 10.1061/(ASCE)0733-9364(2003)129:5(475) PG 10 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA 723JL UT WOS:000185429200001 ER PT J AU Ye, XF Ruan, R Chen, P Chang, KH Ning, K Taub, IA Doona, C AF Ye, XF Ruan, R Chen, P Chang, KH Ning, K Taub, IA Doona, C TI Accurate and fast temperature mapping during ohmic heating using proton resonance frequency shift MRI thermometry SO JOURNAL OF FOOD ENGINEERING LA English DT Article DE PRF shift; MRI thermometry; ohmic heating; temperature mapping; FLASH; whey gel ID DEPENDENCE; FLASH; LIVER; WATER AB Proton resonance frequency (PRF) shift MRI thermometry was incorporated into a fast low angle shot imaging sequence to acquire two-dimensional temperature maps of two model liquid-particulate mixtures undergoing ohmic heating process. The samples used consisted of two phases, namely whey gel and NaCl solution, and were enclosed in an in-house made ohmic heating device driven by an 143 VAC power supply. Salt was added to the gel and solution to alter their electrical conductivity. The PRF shift was used as a temperature indicator, which was linearly and reversibly proportional to the temperature change. The specific PRF shift for the whey gel was determined as -0.0098 and -0.0097 ppm/degreesC for the two samples. For the NaCl solution, the values were -0.0096 and -0.0102 ppm/degreesC, respectively. Detailed temperature maps with spatial resolution of 0.94 mm and temporal resolution of 0.64 s were obtained. The temperature uncertainties were about +/-1 degreesC for the whey gel and +/-2 degreesC for the solution. The ease to interpret, the speed, and the accuracy of this new technique justify its applications in dynamic food process. The temperature maps provided details for the investigation of uneven heating of a liquid-particulate mixture undergoing ohmic heating and this temperature mapping technique is a powerful tool for ohmic model development and validation. (C) 2003 Elsevier Science Ltd. All rights reserved. C1 Univ Minnesota, Dept Agr & Biosyst Engn, St Paul, MN 55108 USA. USA, Natick Solider Ctr, Natick, MA 01760 USA. RP Ruan, R (reprint author), Univ Minnesota, Dept Agr & Biosyst Engn, 1390 Eckles Ave, St Paul, MN 55108 USA. EM ruanx001@umn.edu OI Ruan, Roger/0000-0001-8835-2649 NR 29 TC 19 Z9 20 U1 2 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0260-8774 EI 1873-5770 J9 J FOOD ENG JI J. Food Eng. PD SEP PY 2003 VL 59 IS 2-3 BP 143 EP 150 DI 10.1016/S0260-8774(02)00450-8 PG 8 WC Engineering, Chemical; Food Science & Technology SC Engineering; Food Science & Technology GA 691ED UT WOS:000183591100007 ER PT J AU Taub, IA Feeherry, FE Ross, EW Kustin, K Doona, CJ AF Taub, IA Feeherry, FE Ross, EW Kustin, K Doona, CJ TI A quasi-chemical kinetics model for the growth and death of Staphylococcus aureus in intermediate moisture bread SO JOURNAL OF FOOD SCIENCE LA English DT Article DE predictive microbiology; quasi-chemical model; S. aureus; growth/death kinetics; intermediate moisture bread ID MICROBIAL-GROWTH; WATER ACTIVITY; LISTERIA-MONOCYTOGENES; MATHEMATICAL-MODELS; BACTERIAL-GROWTH; SODIUM-CHLORIDE; PH; ENVIRONMENTS; TEMPERATURE; INTERFACE AB The "quasi-chemical" kinetics model accounts for all 4 phases of the microbial lifecycle based on a proposed series of chemical rate equations. The model fits continuous growth-death kinetics for Staphylococcus aureus in intermediate moisture bread in various conditions of water activity, pH, and temperature. Growth rates evaluated using the quasi-chemical model are compared with values obtained with the Gompertz model. Kinetics data obtained with the quasi-chemical model are integrated with a probabilistic approach to estimate the boundary between growth and no-growth conditions. Continuous modeling of microbial growth/death kinetics in actual foods advances predictive modeling that conventionally separates growth and death models. C1 USA, Soldier Biol & Chem Command, Natick Soldier Ctr, Combat Feeding Innovat Sci Team, Natick, MA 01760 USA. Brandeis Univ, Dept Chem, Waltham, MA 02251 USA. RP USA, Soldier Biol & Chem Command, Natick Soldier Ctr, Combat Feeding Innovat Sci Team, Kansas St, Natick, MA 01760 USA. EM Christopher.Doona@natick.army.mil NR 59 TC 27 Z9 27 U1 0 U2 4 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1147 EI 1750-3841 J9 J FOOD SCI JI J. Food Sci. PD SEP PY 2003 VL 68 IS 8 BP 2530 EP 2537 DI 10.1111/j.1365-2621.2003.tb07056.x PG 8 WC Food Science & Technology SC Food Science & Technology GA 739ZV UT WOS:000186377100022 ER PT J AU Wainner, RS AF Wainner, RS TI Reliability of the clinical examination: How close is "close enough"? SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material ID LOW-BACK-PAIN; PREDICTION RULE; AGREEMENT C1 Baylor Univ, USA, USA Baylor Grad Program Phys Therapy, Ft Sam Houston, TX USA. RP Wainner, RS (reprint author), Baylor Univ, USA, USA Baylor Grad Program Phys Therapy, Ft Sam Houston, TX USA. NR 13 TC 16 Z9 16 U1 0 U2 0 PU J O S P T, ALLIANCE GROUP COMMUNICATIONS PI LAWRENCE PA 810 EAST 10TH ST, PO BOX 1897, LAWRENCE, KS 66044-8897 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD SEP PY 2003 VL 33 IS 9 BP 488 EP 491 PG 4 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 723JJ UT WOS:000185429000001 PM 14524507 ER PT J AU Langford, BJ Jones, EM Cowan, JE Hollingsworth, DJ Deyle, GD Christie, DS Allison, SC AF Langford, BJ Jones, EM Cowan, JE Hollingsworth, DJ Deyle, GD Christie, DS Allison, SC TI The effects of treadmill type on heart rate and pain threshold velocity in individuals with lower-extremity musculoskeletal pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE ambulation; running; walking ID VISUAL ANALOG; INJURIES; SCALES AB Study Design: This study utilized a quasi-experimental design in which subjects served as their own controls. Objective: To determine whether heart rate, pain threshold velocity, and pain perception varied in patients running on a soft-belt treadmill versus a standard hard-belt treadmill. Background: According to promotional literature, the relatively new Orbiter soft-belt treadmill produces a greater increase in heart rate at a given velocity as well as a higher velocity tolerance while walking or running. The manufacturer also asserts that decreased forces transmitted through the lower extremity should decrease pain levels while exercising on the soft-belt treadmill. Methods and Measures: Twenty-seven subjects walked or ran on each of 2 treadmills at incrementally increasing velocities until they experienced either the onset of pain or an increase in pain from baseline levels. Locomotion continued for 2 minutes after that, during which time heart rate and pain level on a visual analog scale (VAS) were recorded. Results: Two univariate paired t tests and a Wilcoxon's signed rank test revealed a greater heart rate and pain threshold velocity when using the soft-belt treadmill with no statistical difference in the pain reported between the 2 treadmills. Conclusion: Our study revealed a 10% higher heart rate and a 14.5% higher pain threshold velocity with the soft-belt treadmill compared to a hard-belt treadmill. These differences are considered clinically meaningful. C1 Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Eglin AFB Hosp, Eglin AFB, FL USA. Marine Corps Recruit Depot, Parris Isl, SC USA. Rocky Mtn Univ Hlth Profess, Provo, UT USA. Baylor Univ, USA, Sci Program Orthopaed & Manual Phys Therapy, Ft Sam Houston, TX USA. Baylor Univ, USA, Grad Program Phys Therapy, Ft Sam Houston, TX USA. USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Jones, EM (reprint author), 2507 Jennings Ct, Silver Spring, MD 20902 USA. NR 16 TC 0 Z9 0 U1 1 U2 3 PU J O S P T, ALLIANCE GROUP COMMUNICATIONS PI LAWRENCE PA 810 EAST 10TH ST, PO BOX 1897, LAWRENCE, KS 66044-8897 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD SEP PY 2003 VL 33 IS 9 BP 532 EP 537 PG 6 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 723JJ UT WOS:000185429000006 PM 14524512 ER PT J AU Tiwary, CM Ward, JA AF Tiwary, CM Ward, JA TI Use of hair products containing hormone or placenta by US military personnel SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM LA English DT Article DE adult; blacks; child; estrogens; hair preparations; military personnel; placental extracts ID BLACK-WHITE DIFFERENCES; SEXUAL DEVELOPMENT; BOGALUSA HEART; CHILDREN; PUBERTY; GIRLS; ESTROGEN; AGE; MATURATION; COSMETICS AB We surveyed 2,097 subjects stationed at a US Army School to study the use of commercial hair products whose labeled ingredients included hormone or placenta. Use of some of these products is associated with premature sexual development. Use by demographics is: All = 14.8%, whites = 6.3%, non-whites = 27.0%; males = 8.7%, females = 24.6%; officers = 7.3%, enlisted = 18.7%. Frequency of use was highest among non-white female enlisted personnel (43 +/- 6.4%) and lowest among white male commissioned officers (2.0 +/- 1.7%). Regardless of ethnicity, 13.4% of respondents' children used the hair product. Use is about four times higher for non-whites than for whites. Females and enlisted personnel are more likely to use the hair product than males or officers. The use of hormonal hair products among children parallels use by their parents. In spite of federal regulation, the use of these hair products is still common. C1 USA, Acad Hlth Sci, Ft Sam Houston, TX USA. USA, Acad Hlth Sci, Army Med Dept Ctr & Sch, Ft Sam Houston, TX USA. Univ Texas, Hlth Sci Ctr, Dept Pediat, San Antonio, TX USA. Brooke Army Med Ctr, Dept Clin Infest, Ft Sam Houston, TX 78234 USA. RP Ward, JA (reprint author), Clin Invest, 3400 Rawley E Chambers Ave Ste A, Ft Sam Houston, TX 78234 USA. NR 26 TC 8 Z9 8 U1 3 U2 8 PU FREUND PUBLISHING HOUSE LTD PI LONDON PA STE 500, CHESHAM HOUSE, 150 REGENT ST, LONDON W1R 5FA, ENGLAND SN 0334-018X J9 J PEDIATR ENDOCR MET JI J. Pediatr. Endocrinol. Metab. PD SEP PY 2003 VL 16 IS 7 BP 1025 EP 1032 PG 8 WC Endocrinology & Metabolism; Pediatrics SC Endocrinology & Metabolism; Pediatrics GA 721XD UT WOS:000185343000011 PM 14513880 ER PT J AU Powers, PA Dinauer, CA Tuttle, RM Francis, GL AF Powers, PA Dinauer, CA Tuttle, RM Francis, GL TI Treatment of recurrent papillary thyroid carcinoma in children and adolescents SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM LA English DT Article DE papillary; thyroid; carcinoma; children; recurrence; mortality; outcome ID TERM FOLLOW-UP; RISK-GROUP DEFINITION; YOUNG-ADULTS; PROGNOSTIC FACTORS; LOCAL RECURRENCE; CANCER; CHILDHOOD; THERAPY; METASTASIS; MANAGEMENT AB Mortality for children with papillary thyroid carcinoma (PTC) is low (less than or equal to10%), but recurrence is frequent (20%). In adults, recurrent PTC has a poor prognosis (50% remission) and a high mortality (16-63%). We hypothesized that treatment of recurrent PTC would be more effective in children than in adults. We reviewed the clinical course of 42 children with PTC in remission. Seven (7/42, 17%) recurred and records were available for six. All six received RAI (median = 130 mCi), and one had a cervical node removed. Five of the six (83%) achieved remission (median duration 67 mo, range 10-99 mo), one had a second recurrence and a third remission, and one patient (17%) had persistent disease. There were no deaths. In conclusion, although we had only one child less than 10 years of age in our study, these and previous data suggest that treatment of recurrent PTC: in children is generally effective. C1 Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Mem Sloan Kettering Canc Ctr, Endocrinol Sect, New York, NY 10021 USA. Uniformed Serv Univ Hlth Sci, F Edward Herbert Sch Med, Dept Pediat, Bethesda, MD 20814 USA. RP Powers, PA (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 39 TC 7 Z9 8 U1 0 U2 0 PU FREUND PUBLISHING HOUSE LTD PI LONDON PA STE 500, CHESHAM HOUSE, 150 REGENT ST, LONDON W1R 5FA, ENGLAND SN 0334-018X J9 J PEDIATR ENDOCR MET JI J. Pediatr. Endocrinol. Metab. PD SEP PY 2003 VL 16 IS 7 BP 1033 EP 1040 PG 8 WC Endocrinology & Metabolism; Pediatrics SC Endocrinology & Metabolism; Pediatrics GA 721XD UT WOS:000185343000012 PM 14513881 ER PT J AU Kraemer, WJ Rubin, MR Haakkinen, K Nindi, BC Marx, JO Volek, JS French, DN Gomez, AL Sharman, MJ Scheett, T Ratamess, NA Miles, MP Mastro, AM VanHeest, JL Maresh, CM Welsch, JR Hymer, WC AF Kraemer, WJ Rubin, MR Haakkinen, K Nindi, BC Marx, JO Volek, JS French, DN Gomez, AL Sharman, MJ Scheett, T Ratamess, NA Miles, MP Mastro, AM VanHeest, JL Maresh, CM Welsch, JR Hymer, WC TI Influence of muscle strength and total work on exercise-induced plasma growth hormone isoforms in women SO JOURNAL OF SCIENCE AND MEDICINE IN SPORT LA English DT Article ID HEAVY-RESISTANCE EXERCISE; FACTOR RESPONSES; MOLECULAR-FORMS; PROTOCOLS; MEN; ANTIBODIES; PITUITARY; RELEASE; GH AB The purpose of this investigation was to determine the influence of physical strength and the ability to do more total work on human growth hormone (GH) variants to a heavy resistance exercise protocol in untrained women. From a distribution of 100 healthy, untrained women, the strongest 10 women (S) and the weakest 10 women W were compared for GH responses pre- and post an acute heavy resistance exercise test (AHRET, 6 sets of 10 RM squats, 2 minutes rest between sets). Blood samples were obtained pre-exercise and immediately post-exercise and subsequently analysed in total as well as fractionated by Sephacryl S-100R column chromatography into three molecular weight size classes: fraction A: >60 kD, fraction B: 30-60 kD, fraction C: < 30 kD. For each total sample as well as each fraction, immunoreactive GH was measured via the Nichols IRMA, while bioactive GH was measured via the hypox rat tibial line bioassay and Diagnostic Systems Laboratory's immunofunctional GH ELISA. No exercise-induced changes or differences between groups were observed in the tibial line bioassay. However, the S group displayed a significantly higher pre-exercise resting value in the total fraction than the W group. Conversely, the W group exhibited a significantly higher pre-exercise value in the smaller molecular weight fraction C. With regards to the immunofunctional and immunoreactive assays, the total fraction, fraction A, and fraction B demonstrated significant (Pless than or equal to0.05) exercise-induced increases in both the S and W group despite no group differences. For the Nichols and immunofunctional assays significant exercise-induced changes were observed in the smaller molecular weight C fraction in the W group but not the S group. However, the S group displayed a significantly higher pre-exercise value in fraction C relative to the W group. These data demonstrate for the first time that differences exist in the GH molecular weight variants between strong and weak untrained women, with the lower molecular weight variants seemingly less responsive to greater amounts of exercise in stronger women, thus suggesting differential regulation of GH molecular weight variants during resistance exercise due to pre-existing physical parameters. C1 Univ Connecticut, Human Performance Lab, Dept Kinesiol, Storrs, CT 06268 USA. Penn State Univ, Lab Sports Med, Ctr Sports Med, University Pk, PA 16802 USA. Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA. Univ Jyvaskyla, Dept Biol Phys Activ, Jyvaskyla, Finland. USA, Environm Med Res Inst, Milit Performance Div, Natick, MA USA. RP Kraemer, WJ (reprint author), Univ Connecticut, Human Performance Lab, Dept Kinesiol, Storrs, CT 06268 USA. RI Sharman, Matt/I-3788-2014; OI Sharman, Matt/0000-0003-1005-4793; Mastro, Andrea/0000-0003-2710-3360 NR 29 TC 9 Z9 9 U1 0 U2 0 PU SPORTS MEDICINE AUSTRALIA PI DICKSON PA PO BOX 237, DICKSON, ACT 2602, AUSTRALIA SN 1440-2440 J9 J SCI MED SPORT JI J. Sci. Med. Sport PD SEP PY 2003 VL 6 IS 3 BP 295 EP 306 DI 10.1016/S1440-2440(03)80023-3 PG 12 WC Sport Sciences SC Sport Sciences GA 737MK UT WOS:000186236200007 PM 14609146 ER PT J AU Kinsley-Scott, TR Norton, SA AF Kinsley-Scott, TR Norton, SA TI Useful plants of dermatology. VII: Cinchona and antimalarials SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID LUPUS-ERYTHEMATOSUS; FEVER BARK C1 Walter Reed Army Med Ctr, Serv Dermatol, Washington, DC 20307 USA. Malcolm Grow Med Ctr, Andrews AFB, MD USA. RP Norton, SA (reprint author), Walter Reed Army Med Ctr, Serv Dermatol, Washington, DC 20307 USA. NR 24 TC 5 Z9 5 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD SEP PY 2003 VL 49 IS 3 BP 499 EP 502 DI 10.1067/S0190-9622(03)01281-7 PG 4 WC Dermatology SC Dermatology GA 716CV UT WOS:000185012000017 PM 12963916 ER PT J AU Gurney, JM Woll, M Storrer, C Gahan, J Kotula, L Shriver, C Ponniah, S Peoples, G AF Gurney, JM Woll, M Storrer, C Gahan, J Kotula, L Shriver, C Ponniah, S Peoples, G TI In vivo monitoring of the immune response in breast cancer patients receiving a HER2/neu peptide vaccine SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 89th Annual Clinical Congress of the American-College-of-Surgeons CY OCT 19-23, 2003 CL CHICAGO, ILLINOIS SP Amer Coll Surg C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2003 VL 197 IS 3 SU S BP S81 EP S82 PG 2 WC Surgery SC Surgery GA 720EH UT WOS:000185248100204 ER PT J AU Kutz, FW Wade, TG Pagac, BB AF Kutz, FW Wade, TG Pagac, BB TI A geospatial study of the potential of two exotic species of mosquitoes to impact the epidemiology of West Nile virus in Maryland SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes albopictus; Ochlerotatus japonicus japonicus; Asian tiger mosquito; West Nile virus; epidemiology; geographic information systems; environmental justice ID UNITED-STATES; JAPONICUS-JAPONICUS; VECTOR COMPETENCE; AEDES-ALBOPICTUS; DISCOVERY; CULICIDAE; DIPTERA; COUNTY AB We used geospatial techniques to study the potential impact of 2 exotic mosquitoes, Aedes albopictus and Ochlerotatus japonicus japonicus, on the epidemiology of West Nile virus in Maryland. These 2 species have established populations in Maryland over the past 15 years. Larvae of both mosquito species are found in natural and artificial water-holding cavities and containers, particularly water in tires. Therefore, we used locations of licensed tire dealers and of tire dumps scheduled for clean up as an index for potential sources of mosquito vectors. This index was expected to underestimate the actual population of source habitats. West Nile virus activity in Maryland during 1999, 2000, and 2001 was indicated by the presence of dead, infected birds, particularly American crows and other corvids; infected pools of mosquitoes; and human and horse infections. Adult females of both mosquito species are aggressive, opportunistic feeders that have been observed to take blood meals from avian and mammalian hosts. Susceptible vertebrate hosts, particularly birds, are ubiquitously distributed throughout the developed areas of the state. This analysis demonstrated a spatial convergence of the virus, the exotic mosquito vectors, and susceptible hosts. This conjunction indicated that these 2 mosquito species have a high potential to serve as bridge vectors and thus, impact the epidemiology of West Nile virus under favorable environmental and climatic conditions. Positive mosquito pools were collected from only the Baltimore-Washington metropolitan corridor, suggesting a newly created enzootic focus for this virus. Land-cover analysis of the sites where virus activity had been detected showed predominantly developed land uses. Analyses of the environmental justice aspects (social, economic, and housing characteristics) of block groups with human West Nile fever cases or with positive mosquito pools were equivocal. Human cases seemed to occur in developed block groups with lower income levels. C1 US EPA, Landscape Ecol Branch, Ft George G Meade, MD 20755 USA. US EPA, Landscape Ecol Branch, Res Triangle Pk, NC 27711 USA. USA, Ctr Hlth Promot & Prevent Med N, Ft George G Meade, MD 20755 USA. RP Kutz, FW (reprint author), 4967 Moonfall Way, Columbia, MD 21044 USA. NR 22 TC 31 Z9 31 U1 0 U2 7 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2003 VL 19 IS 3 BP 190 EP 198 PG 9 WC Entomology SC Entomology GA 722LB UT WOS:000185375300002 PM 14524539 ER PT J AU Abbott, KC Yuan, CM Taylor, AJ Cruess, DF Agodoa, LYC AF Abbott, KC Yuan, CM Taylor, AJ Cruess, DF Agodoa, LYC TI Early renal insufficiency and hospitalized heart disease after renal transplantation in the era of modern immunosuppression SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ACUTE CORONARY SYNDROMES; ACUTE MYOCARDIAL-INFARCTION; UNITED-STATES; CARDIOVASCULAR-DISEASE; SERUM CREATININE; ESRD PATIENTS; RISK-FACTORS; RECIPIENTS; SURVIVAL; MORTALITY AB Renal insufficiency has been identified as a risk factor for graft loss and death after renal transplantation but has not been consistently linked to early, nonfatal, hospitalized heart disease (HHD). With the United States Renal Data System database, 29,597 patients who received a kidney transplant between January 1, 1996, and July 31, 2000, with Medicare as the primary payer, and were monitored until December 31, 2000, were studied. Cox proportional-hazards regression models were used to calculate the association of recipient estimated GFR (eGFR) at 1 yr after renal transplantation, as determined with the Modification of Diet in Renal Disease formula, with hospitalization for treatment of acute coronary syndromes (ACS) (International Classification of Diseases, version 9, code 410.x or 411.x) or congestive heart failure (CHF) (code 428.x) 1 to 3 yr after renal transplantation. Rates of ACS and CHF were 2.2 and 4.9%, respectively, for patients with eGFR of <44.8 ml/min per 1.73 m(2), compared with 1.2 and 1.4% for patients with eGFR of >69.7 ml/min per 1.73 m(2). Reduced eGFR (<44.8 ml/min per 1.73 m(2), compared with >69.7 ml/min per 1.73 m(2)) at the end of the first 1 yr after transplantation was independently associated with increased risks of both ACS (adjusted hazard ratio, 2.16; 95% confidence interval, 1.39 to 3.35) and CHF (adjusted hazard ratio, 2.95; 95% confidence interval, 2.24 to 3.90). It was concluded that early renal insufficiency (approximately stage 3 chronic kidney disease) was associated with higher rates of HHD I to 3 yr after kidney transplantation. Preservation of renal function after renal transplantation may reduce the rates of HHD, and renal transplant recipients with reduced eGFR should be considered at high risk of developing cardiovascular disease. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. NIDDKD, NIH, Bethesda, MD 20892 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 43 TC 42 Z9 46 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD SEP PY 2003 VL 14 IS 9 BP 2358 EP 2365 DI 10.1097/01.ASN.0000083008.25305.67 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 716JR UT WOS:000185025500018 PM 12937314 ER PT J AU Luckett, JA AF Luckett, JA TI Unknown tongues: Black women's political activism in the antebellum era, 1830-1860 SO JOURNAL OF THE EARLY REPUBLIC LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Luckett, JA (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC HISTORIANS EARLY AMERICAN REPUBLIC PI W LAFAYETTE PA PURDUE UNIV, 1358 UNIV HALL, W LAFAYETTE, IN 47907-1358 USA SN 0275-1275 J9 J EARLY REPUBL JI J. Early Repub. PD FAL PY 2003 VL 23 IS 3 BP 453 EP 456 DI 10.2307/3595050 PG 4 WC History SC History GA 760NJ UT WOS:000187840200007 ER PT J AU Murphy, MG Skonberg, DI Camire, ME Dougherty, MP Bayer, RC Briggs, JL AF Murphy, MG Skonberg, DI Camire, ME Dougherty, MP Bayer, RC Briggs, JL TI Chemical composition and physical properties of extruded snacks containing crab-processing by-product SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE LA English DT Article; Proceedings Paper CT Annual Meeting of the Institute-of-Food-Technologists CY JUN 10-15, 2000 CL DALLAS, TEXAS SP Inst Food Technologists DE extrusion; by-product utilisation; snack food; crab processing ID TWIN-SCREW EXTRUSION; RICE FLOUR; FISH; CALCIUM; BLENDS AB The crab-processing industries generate millions of pounds of by-product annually, which results in a loss of edible product and presents a considerable waste disposal problem. The purpose of this research was to investigate the use of crab-processing by-product (CB) in the development of a calcium-rich expanded snack. The specific objectives were to examine the effects of type of CB (wet or dry), feed composition and screw speed (150 or 250 rpm) on selected properties of extruded snacks. Product formulations consisting of 0-400 g kg(-1) CB combined with corn meal and potato flakes were processed in a twin-screw extruder. The resulting extrudates were analysed for proximate and mineral (calcium, sodium) composition, pH, water activity (a(w)), total plate count, bulk density, expansion ratio and colour. Both CB type and level of incorporation had significant effects (P < 0.05) on the calcium content, expansion ratio, bulk density and pH of the extrudates. Increasing the CB level resulted in increased calcium content (from S. 1 to 52.4 mg g(-1)) and pH (from 6.1 to 8.8). Screw speed had no significant effects (P > 0.05) on expansion ratio and bulk density. A high processing temperature (157degreesC) and low aw resulted in undetectable microbial growth on the extrudates. This research demonstrates that ground crab-processing by-product can be successfully incorporated into an expanded snack product. Further research will evaluate consumer response to this novel value-added product. (C) 2003 Society of Chemical Industry. C1 Univ Maine, Dept Food Sci & Human Nutr, Orono, ME 04469 USA. Univ Maine, Lobster Inst, Orono, ME 04469 USA. USA, CFP, Natick Soldier Ctr, SBCCOM, Natick, MA 01760 USA. RP Skonberg, DI (reprint author), Univ Maine, Dept Food Sci & Human Nutr, 5735 Hitchner Hall, Orono, ME 04469 USA. NR 19 TC 12 Z9 12 U1 3 U2 9 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0022-5142 J9 J SCI FOOD AGR JI J. Sci. Food Agric. PD SEP 1 PY 2003 VL 83 IS 11 BP 1163 EP 1167 DI 10.1002/jsfa.1520 PG 5 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 711BU UT WOS:000184719400012 ER PT J AU Wade, CE Dubick, MA Grady, JJ AF Wade, CE Dubick, MA Grady, JJ CA HSD Dev Grp TI Optimal dose of hypertonic saline/dextran in hemorrhaged swine SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE survival; fluid resuscitation; injury; hypotension ID 7.5-PERCENT SODIUM-CHLORIDE; 6-PERCENT DEXTRAN-70; UNCONTROLLED HEMORRHAGE; PREHOSPITAL MANAGEMENT; MULTICENTER TRIAL; INJURED PATIENTS; TRAUMA PATIENTS; RESUSCITATION; SHOCK; NACL AB Background: Hypertonic saline/dextran (HSD) fluid resuscitation has been demonstrated to be effective in alleviating the adverse effects of hemorrhagic hypotension. The optimal dose of HSD has not been defined. Method: The comparative effectiveness of various dosages of HSD for the treatment of severe hemorrhage was investigated in conscious swine bled 46 mL/kg over 15 minutes, a lethal procedure. Five minutes after the completion of hemorrhage, animals were treated with 1, 2,4, or 11.5 mL/kg HSD and observed over the next 96 hours. Results: The 11.5-mL dose resulted in 100% survival, which was statistically superior to the 1- and 2-mL doses but not the 4-mL dose. Survival incidences with 4, 2, and 1 mL/kg were 83%, 64%, and 13%, respectively. Conclusion: in terms of survival time, the 11.5- and 4-mL/kg doses were not significantly different. Therefore, optimum resuscitative effectiveness of HSD is achieved within the dose range of 4 to 11.5 mL/kg. C1 BioPhausia AB, Uppsala, Sweden. USA, Inst Surg Res, San Antonio, TX USA. Univ Texas, Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77550 USA. RP Wade, CE (reprint author), 109 Pearl St, Sausalito, CA 94965 USA. NR 27 TC 11 Z9 12 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 2003 VL 55 IS 3 BP 413 EP 416 DI 10.1097/01.TA.0000057247.02378.5E PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 721DZ UT WOS:000185302900004 PM 14501880 ER PT J AU Park, MS Cancio, LC Batchinsky, AI McCarthy, MJ Jordan, BS Brinkley, WW Dubick, MA Goodwin, CW AF Park, MS Cancio, LC Batchinsky, AI McCarthy, MJ Jordan, BS Brinkley, WW Dubick, MA Goodwin, CW TI Assessment of severity of ovine smoke inhalation injury by analysis of computed tomographic scans SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 16th Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 15-18, 2003 CL FT MYERS, FLORIDA SP Eastern Assoc Surg Trauma DE smoke inhalation injury; lung; adult respiratory distress syndrome; sheep; computed tomography; radiograph ID RESPIRATORY-DISTRESS-SYNDROME; INDUCED LUNG INJURY; SHEEP MODEL; FAILURE; PULMONARY; VENTILATION; PRESSURE; POSITION; DENSITY; BURNS AB Background: Our goal was to evaluate computed tomographic (CT) scans of the chest as a means of stratifying smoke inhalation injury (SII) severity. Methods: Twenty anesthetized sheep underwent graded SII: group I, no smoke; group II, 5 smoke units; group III, 10 units; and group IV, 16 units. CT scans were obtained at 6, 12, and 24 hours after injury. Each quadrant of each slice was scored subjectively: 0 = normal, 1 = interstitial markings, 2 = ground-glass appearance, and 3 = consolidation. The sum of all scores was the radiologist's score (RADS) for that scan. Computerized analysis of three-dimensional reconstructed scans was also performed, based on Hounsfield unit ranges: hyperinflated, -1,000 to -900; normal, -899 to -500; poorly aerated, -499 to -100; and nonaerated, -99 to +100. The fraction of abnormal lung tissue (FALT) was computed from poorly aerated, nonaerated, and total volumes. Mean gray-scale density (DENS) was also computed. Results: SII resulted in severity- and time-related changes in oxygenation (alveolar-arterial gradient), ventilation (respiratory rate-pressure product), DENS, FALT, and RADS. Ordinal logistic regression generated a predictive model for severity of injury (r(2) = 0.623, p = 0.001), retaining RADS at 24 hours and rejecting the other variables. Conclusion: At 24 hours, CT scanning enabled SII severity stratification; qualitative evaluation (RADS) outperformed current semiautomated methods (DENS, FALT). C1 USA, Inst Surg Res, Lib Branch, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. Univ Texas, Hlth Sci Ctr, Dept Radiol, San Antonio, TX 78284 USA. Univ Penn, Sch Med, Dept Surg, Div Traumatol & Surg Crit Care, Philadelphia, PA 19104 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, Lib Branch, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 29 TC 34 Z9 35 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 2003 VL 55 IS 3 BP 417 EP 427 DI 10.1097/01.TA.0000083609.24440.7F PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 721DZ UT WOS:000185302900005 PM 14501881 ER PT J AU Pusateri, AE Modrow, HE Harris, RA Holcomb, JB Hess, JR Mosebar, RH Reid, TJ Nelson, JH Goodwin, CW Fitzpatrick, GM McManus, AT Zolock, DT Sondeen, JL Cornum, RL Martinez, RS AF Pusateri, AE Modrow, HE Harris, RA Holcomb, JB Hess, JR Mosebar, RH Reid, TJ Nelson, JH Goodwin, CW Fitzpatrick, GM McManus, AT Zolock, DT Sondeen, JL Cornum, RL Martinez, RS TI Advanced hemostatic dressing development program: Animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in swine SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID FIBRIN ADHESIVE BANDAGE; N-ACETYL GLUCOSAMINE; V LIVER INJURIES; HYPOTHERMIC COAGULOPATHIC SWINE; BLOOD-LOSS; RESUSCITATION VOLUME; BISMUTH SUBGALLATE; SEALANT DRESSINGS; COLLAGEN; THROMBIN AB Background: An advanced hemostatic dressing is needed to augment current methods for the control of life-threatening hemorrhage. A systematic approach to the study of dressings is described. We studied the effects of nine hemostatic dressings on blood loss using a model of severe venous hemorrhage and hepatic injury in swine. Methods: Swine were treated using one of nine hemostatic dressings. Dressings used the following primary active ingredients: microfibrillar collagen, oxidized cellulose, thrombin, fibrinogen, propyl gallate, aluminum sulfate, and fully acetylated poly-N-acetyl glucosamine. Standardized liver injuries were induced, dressings were applied, and resuscitation was initiated. Blood loss, hemostasis, and 60-minute survival were quantified. Results: The American Red Cross hemostatic dressing (fibrinogen and thrombin) reduced (p < 0.01) posttreatment blood loss (366 mL; 95% confidence interval, 175-762 mL) and increased (p < 0.05) the percentage of animals in which hemostasis was attained (73%), compared with gauze controls (2,973 mL; 95% confidence interval, 1,414-6,102 mL and 0%, respectively). No other dressing was effective. The number of vessels lacerated was positively related to pretreatment blood loss and negatively related to hemostasis. Conclusion: The hemorrhage model allowed differentiation among topical hemostatic agents for severe hemorrhage. The American Red Cross hemostatic dressing was effective and warrants further development. C1 USA, Inst Surg Res, Library Branch, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. USA, Med Dept & Sch, Ft Sam Houston, TX USA. Univ Texas, Sch Med, Houston, TX USA. USA, Med Mat Dev Act, Ft Detrick, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. USA, Med Command, Off Surgeon Gen, Falls Church, VA USA. 28th Combat Support Hosp, Ft Bragg, NC USA. RP Pusateri, AE (reprint author), USA, Inst Surg Res, Library Branch, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 64 TC 85 Z9 93 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 2003 VL 55 IS 3 BP 518 EP 526 DI 10.1097/01.TA.0000075336.92129.27 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 721DZ UT WOS:000185302900027 PM 14501897 ER PT J AU Horvath, LL Murray, CK DuPont, HL AF Horvath, LL Murray, CK DuPont, HL TI Travel health information at commercial travel websites SO JOURNAL OF TRAVEL MEDICINE LA English DT Article; Proceedings Paper CT 8th Conference of the International-Society-of-Travel-Medicine CY MAY, 2003 CL NEW YORK, NEW YORK SP Int Soc Travel Med ID RESOURCES; INTERNET AB Background. Internet travel purchases accounted for 10% of the travel industry revenue generated in 2001. To ensure that travelers remain healthy during excursions to developing countries, travel health information needs to be available at commercial travel websites. We evaluated the current availability of travel health information at these websites. Methods: The existence, adequacy and ease of access of the travel health information provided on commercial travel websites was assessed through a review of the top 25 airline and 20 discount travel websites. Each site was examined to determine whether it provided general information, such as jet lag, or international travel health information, such as malaria prophylaxis. We also assessed hyperlinks to external travel health information websites, such as the CDC, when provided. Results: Travel health information was not available at 20 (44%) commercial travel websites, including 36% of airline and 55% of the discount travel websites. Twenty-eight percent of airline websites contained general information only, 8% links only, and 28% general and international information. Travel health information available at discount travel websites included 10% general only, 30% link only, and 5% general and international information. On average, it took three clicks to access travel health information. Keywords clicked to access travel health information frequently did not obviously refer to health. Each of the six travel health website links provided accurate vaccine and travel health information. However, several links lacked disease-specific maps and details of disease risk (i.e. seasonal and regional variations of malaria risk). Conclusions. Travel health information on commercial travel websites may be the only data available to travelers purchasing online. The information currently provided is generally inadequate. Ideally, commercial travel websites would provide uniform information that is accurate and easily accessible. Internationally recognized organizations should consider establishing guidelines for the information provided on commercial travel websites. C1 Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, Dept Med, Ft Sam Houston, TX 78234 USA. St Lukes Episcopal Hosp, Houston, TX 77030 USA. Univ Texas, Ctr Infect Dis, Houston Sch Publ Hlth, Houston, TX USA. Baylor Coll Med, Dept Med, Houston, TX 77030 USA. RP Horvath, LL (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 9 TC 12 Z9 12 U1 0 U2 4 PU B C DECKER INC PI HAMILTON PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD SEP-OCT PY 2003 VL 10 IS 5 BP 272 EP 279 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 730WR UT WOS:000185853600005 PM 14531980 ER PT J AU Overberg, ME Thaler, GT Frazier, RM Abernathy, CR Pearton, SJ Rairigh, R Kelly, J Theodoropoulou, NA Hebard, AF Wilson, RG Zavada, JM AF Overberg, ME Thaler, GT Frazier, RM Abernathy, CR Pearton, SJ Rairigh, R Kelly, J Theodoropoulou, NA Hebard, AF Wilson, RG Zavada, JM TI Magnetic properties of Mn-implanted AlGaP alloys SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID MOLECULAR-BEAM EPITAXY; FERROMAGNETIC SEMICONDUCTORS; ION-IMPLANTATION; P-GAN AB Ion implantation of Mn at concentrations of 1-5 at. % was performed in AlxGa1-xP:C (x = 0, 0.24, 0.38, and 0.54) epilayers grown by gas source molecular beam epitaxy. Ferromagnetic-like ordering at 300 K was observed for Mn doses up to 3 at. % for all Al subtractions in superconducting quantum interference device measurements. The calculated magnetic moment was found to peak at 3 at. % Mn in plots of magnetization versus Mn for all four Al subfractions. For a given Mn concentration, the magnetic moment was found to initially increase then decrease in plots of magnetization versus Al subfraction. Structural characterization revealed the presence of the Mn2P and Mn3Ga phases in Al0.54Ga0.46P:C layers implanted with 5 at. % Mn, while no second phases were observed in any other combinations of Al and Mn. A substantial increase in magnetic ordering temperature predicted by theory for AlxGa1-xP:C films compared to GaP:C films with Mn incorporation was not observed. (C) 2003 American Vacuum Society. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Phys, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Overberg, ME (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. NR 18 TC 2 Z9 2 U1 1 U2 6 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD SEP-OCT PY 2003 VL 21 IS 5 BP 2093 EP 2097 DI 10.1116/1.1609473 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 735QU UT WOS:000186126700019 ER PT J AU Custer, DM Thompson, E Schmaljohn, CS Ksiazek, TG Hooper, JW AF Custer, DM Thompson, E Schmaljohn, CS Ksiazek, TG Hooper, JW TI Active and passive vaccination against hantavirus pulmonary syndrome with Andes virus M genome segment-based DNA vaccine SO JOURNAL OF VIROLOGY LA English DT Article ID HUMORAL IMMUNE-RESPONSES; TO-PERSON TRANSMISSION; CREEK-CANAL VIRUS; HANTAAN VIRUS; MONOCLONAL-ANTIBODIES; HEMORRHAGIC-FEVER; NAKED DNA; INFECTION; OUTBREAK; ARGENTINA AB Hantavirus pulmonary syndrome (HPS) is a rapidly progressing human disease with one of the highest case fatality rates (30 to 50%) of any acute viral disease known. There are no vaccines, effective antiviral drugs, or immunologics to prevent or treat HPS. In an attempt to develop HPS medical countermeasures, we constructed an expression plasmid, pWRG/AND-M, that contains the full-length M genome segment of Andes virus (ANDV), a South American hantavirus. Transfection experiments in cell culture indicated that both the G1 and G2 glycoproteins are expressed from pWRG/AND-M. Rhesus macaques vaccinated by gene gun with pWRG/AND-M developed remarkably high levels of neutralizing antibodies that not only neutralized ANDV but also cross-neutralized other HPS-associated hantaviruses, including Sin Nombre virus. To determine if the antibodies elicited in the monkeys could confer protection, we performed a series of passive-transfer experiments using a recently described lethal HPS animal model (i.e., adult Syrian hamsters develop HPS and die within 10 to 15 days after challenge with ANDV). When injected into hamsters 1 day before challenge, sera from the vaccinated monkeys either provided sterile protection or delayed the onset of HPS and death. When injected on day 4 or 5 after challenge, the monkey sera protected 100% of the hamsters from lethal disease. These data provide a proof of concept for a gene-based HPS vaccine and also demonstrate the potential value of a postexposure immunoprophylactic to treat individuals after exposure, or potential exposure, to these highly lethal hantaviruses. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. Ctr Dis Control & Prevent, Atlanta, GA USA. RP Hooper, JW (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. OI Hooper, Jay/0000-0002-4475-0415 NR 31 TC 78 Z9 85 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD SEP PY 2003 VL 77 IS 18 BP 9894 EP 9905 DI 10.1128/JVI.77.18.9894-9905.2003 PG 12 WC Virology SC Virology GA 716TX UT WOS:000185046200018 PM 12941899 ER PT J AU Manous, JD Stefan, HG AF Manous, JD Stefan, HG TI Projected sulfate redistribution as impacted by lake level stabilization scenarios: Devils Lake, North Dakota SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article DE dispersion; floods; lakes; North Dakota; salinity; water quality AB Devils Lake, a terminal, saline lake, of glacial origin, in North Dakota has experienced a 7.5 in rise in lake elevation resulting in the flooding of over 243 km(2) from 1992 to 2002. At lower water surface elevations, Devils Lake functions as a series of connected basins with salinity increasing in an eastward direction due to evaporation. The recent increase in water depth provides an opportunity for increased dispersive exchange flows and mixing between the lake's basins due to wind and buoyancy forces. This increased mixing will change the future water quality distribution in Devils Lake, and may therefore have an impact on plans for lake level stabilization. In this paper, a model based on energy and conservation of mass principles is applied to estimate the potential redistribution of sulfate within Devils Lake. The rate of redistribution may affect the lake's ecosystem and the design of a possible water diversion to the Red River of the North for the purpose of stabilizing the water surface elevation. Included in the paper is the selection of model input parameters, model calibration with field measurements, and application of the model to five, future scenarios. C1 US Mil Acad, Dept Geog & Environm Engn, W Point, NY 10996 USA. Univ Minnesota, Dept Civil Engn, Minneapolis, MN 55455 USA. RP Manous, JD (reprint author), US Mil Acad, Dept Geog & Environm Engn, W Point, NY 10996 USA. NR 20 TC 1 Z9 1 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD SEP-OCT PY 2003 VL 129 IS 5 BP 399 EP 408 DI 10.1061/(ASCE)0733-9496(2003)129:5(399) PG 10 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 712DZ UT WOS:000184783100006 ER PT J AU Butkus, MA Edling, L Labare, MP AF Butkus, MA Edling, L Labare, MP TI The efficacy of silver as a bactericidal agent: advantages, limitations and considerations for future use SO JOURNAL OF WATER SUPPLY RESEARCH AND TECHNOLOGY-AQUA LA English DT Article DE disinfection; E. coli; minimum inhibitory concentration; point-of-use filters; silver ID ESCHERICHIA-COLI; ACTIVATED CARBON; NATURAL-WATERS; COPPER-SILVER; IONS; SPECIATION; RESISTANCE; CHLORINE; BIOAVAILABILITY; DISINFECTION AB This work examined the efficacy of silver as a bactericidal agent against Escherichia Coli. The minimum inhibitory concentration (MIC) for Ag(l) was observed to be between 0.1 mg Ag/I and 0.05 mg Ag/I following a 24-h incubation period at 25degreesC. Additional forms of silver that were effective included Ag2O a protein-based silver and AgCl(s). All of these forms of silver resulted in MICs that, were comparable to Ag(I). Predictions from a chemical equilibrium modelling system indicated that a silver-histidine complex may have contributed to the observed bactericidal activity. A MIC for colloidal metallic silver (Ag-0) was not observed up to a total silver concentration of 82 mg Ag/I-the highest concentration evaluated. Moreover, aqueous silver was not detected at this total silver concentration. it was concluded from these findings that cationic Ag(I) or Ag(I)-complexes were responsible for the bactericidal activity of silver. in the batch systems evaluated, the MICs increased with time, over a 72-h incubation period, to values above the US Environmental Protection Agency Secondary Standard for silver, for all forms of silver tested. A desorption kinetics study indicated that less than 10% of silver was readily leachable from a granular activated carbon surface that was first saturated with silver. C1 US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, W Point, NY 10996 USA. GeoTrans Inc, Rancho Cordova, CA 95670 USA. US Mil Acad, Dept Chem & Life Sci, W Point, NY 10996 USA. RP Butkus, MA (reprint author), US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, W Point, NY 10996 USA. NR 39 TC 42 Z9 42 U1 3 U2 10 PU I W A PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 0003-7214 J9 J WATER SUPPLY RES T JI J. Water Supply Res Technol.-Aqua PD SEP PY 2003 VL 52 IS 6 BP 407 EP 416 PG 10 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 731XB UT WOS:000185910800002 ER PT J AU Kobayashi, N Pozueta, B Melby, JA AF Kobayashi, N Pozueta, B Melby, JA TI Performance of coastal structures against sequences of hurricanes SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE rubble-mound breakwaters; hurricanes; storm surges; wind waves; overtopping; coastal structures ID MODEL AB A synthesis of existing models and formulas is made to compute the virtual performance of rubble mound structures in shallow water under combined storm surge and breaking waves for sequences of hurricanes. The computed results for ten 500-year simulations are presented for a typical structure as an example. The crest height and armor weight of the structure are designed against the peak of a 100-year storm. The structure designed conventionally is exposed to approximately 350 storms for each 500-year simulation. The computed wave overtopping rate and volume during the entire duration of each storm are analyzed to assess the severity of flooding hazards. The computed progression of damage to the armor layer is caused episodically by several major storms but slows down as the structure ages. The computed results are also used to quantify the equivalent duration of the peak of a storm that yields the same overtopping water Volume and damage increment as those computed for the entire storm duration. C1 Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Kobayashi, N (reprint author), Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. RI Martin Hidalgo, Melva/A-4171-2011 NR 25 TC 5 Z9 5 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD SEP-OCT PY 2003 VL 129 IS 5 BP 219 EP 228 DI 10.1061/(ASCE)0733-950X(2003)129:5(219) PG 10 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 712BQ UT WOS:000184776700004 ER PT J AU Stockstill, RL AF Stockstill, RL TI Mooring model coefficients for barge tows in a navigation lock SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE mooring; navigation; locks; models AB The equations of motion of a spring-mass system are used to describe a vessel's mooring system. These equations employ added mass and hydrodynamic damping coefficients, which depend on vessel shape and the proximity of free-surface and solid boundaries. The present study has experimentally determined these coefficients for barge tows moored in the chamber of navigation locks. Seven lock chamber configurations were tested in which the width, depth, and length of the chamber and the beam width and length of the tow were varied. Values of the added mass coefficient and a nondimensional form of the damping coefficient are presented. Subsequent to modeling flow in a lock chamber, these coefficients can be used in conjunction with hawser properties (spring constants) to estimate hawser forces generated during locking operations. C1 USA, Ctr Res Dev & Engn, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Stockstill, RL (reprint author), USA, Ctr Res Dev & Engn, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 10 TC 0 Z9 0 U1 1 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD SEP-OCT PY 2003 VL 129 IS 5 BP 233 EP 236 DI 10.1061/(ASCE)0733-950X(2003)129:5(233) PG 4 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 712BQ UT WOS:000184776700006 ER PT J AU Wyatt, LT AF Wyatt, LT TI Visions of war: Picturing warfare from the stone age to the cyber age. SO JOURNAL OF WORLD HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Wyatt, LT (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU UNIV HAWAII PRESS PI HONOLULU PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA SN 1045-6007 J9 J WORLD HIST JI J. World Hist. PD SEP PY 2003 VL 14 IS 3 BP 396 EP 399 DI 10.1353/jwh.2003.0044 PG 4 WC History SC History GA 706CN UT WOS:000184434500005 ER PT J AU Abbott, KC AF Abbott, KC TI Reverse epidemiology and obesity in maintenance dialysis patients SO KIDNEY INTERNATIONAL LA English DT Letter ID RENAL-DISEASE PATIENTS; BODY-MASS INDEX; SURVIVAL C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. NR 5 TC 4 Z9 4 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD SEP PY 2003 VL 64 IS 3 BP 1138 EP 1138 DI 10.1046/j.1523-1755.2003.00166.x PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 711GY UT WOS:000184732300044 PM 12911569 ER PT J AU Fedotov, AB Bugar, I Sidorov-Biryukov, DA Serebryannikov, EE Chorvat, D Scalora, M Chorvat, D Zheltikov, AM AF Fedotov, AB Bugar, I Sidorov-Biryukov, DA Serebryannikov, EE Chorvat, D Scalora, M Chorvat, D Zheltikov, AM TI Nonlinear-optical spectral transformation of ultrashort pulses in microstructure fibers: Extending the capabilities of femtosecond laser sources SO LASER PHYSICS LA English DT Article; Proceedings Paper CT 11th International Laser Physics Workshop (LPHYS 02) CY JUL 01-05, 2002 CL BRATISLAVA, SLOVAKIA ID PHOTONIC-CRYSTAL FIBERS; SUPERCONTINUUM GENERATION; ANOMALOUS-DISPERSION; CONTINUUM GENERATION; TAPERED FIBERS; HOLEY FIBERS; LIGHT; SPECTROSCOPY; CLOCK; NM AB Microstructure fibers are shown to provide a high efficiency of nonlinear-optical spectral transformation and frequency conversion of ultrashort laser pulses, extending the capabilities of femtosecond laser systems. Strategies for the optimization of frequency conversion and spectral superbroadening of femtosecond pulses produced by an optical parametric amplifier and a Ti: sapphire laser are considered. Pump-depleting frequency conversion of 800-nm radiation to the spectral range around 500 nm through phase-matched parametric four-wave mixing is demonstrated for 80-fs pulses of a Ti: sapphire laser. C1 Moscow MV Lomonosov State Univ, Fac Phys, Moscow 119899, Russia. Moscow MV Lomonosov State Univ, Ctr Int Laser, Moscow 119899, Russia. Ctr Int Laser, Bratislava 81219, Slovakia. USA, Aviat & Missile Command, Weapons Sci Directorate, Huntsville, AL 35898 USA. RP Fedotov, AB (reprint author), Moscow MV Lomonosov State Univ, Fac Phys, Vorobevy Gory, Moscow 119899, Russia. RI Serebryannikov, Evgeny/M-2583-2014; Bugar, Ignac/A-6725-2015 OI Bugar, Ignac/0000-0001-5228-9844 NR 40 TC 1 Z9 1 U1 0 U2 1 PU INTERPERIODICA PI BIRMINGHAM PA PO BOX 1831, BIRMINGHAM, AL 35201-1831 USA SN 1054-660X J9 LASER PHYS JI Laser Phys. PD SEP PY 2003 VL 13 IS 9 BP 1222 EP 1229 PG 8 WC Optics; Physics, Applied SC Optics; Physics GA 728PN UT WOS:000185725700016 ER PT J AU Stahl, PA AF Stahl, PA TI The legal assistance attorney's guide to immigraton and naturalization SO MILITARY LAW REVIEW LA English DT Article C1 USA, Judge Advocate Gen Sch, Ctr Law & Mil Oper, CLAMO,, Charlottesville, VA 22901 USA. RP Stahl, PA (reprint author), USA, Judge Advocate Gen Sch, Ctr Law & Mil Oper, CLAMO,, Charlottesville, VA 22901 USA. NR 11 TC 1 Z9 1 U1 8 U2 8 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2003 VL 177 BP 1 EP 48 PG 48 WC Law SC Government & Law GA 759NF UT WOS:000187743200002 ER PT J AU Daknis, WP AF Daknis, WP TI Home sweet home: A practical approach to domicile SO MILITARY LAW REVIEW LA English DT Article C1 USA, Airborne Corps XVIII, Ft Bragg, NC USA. RP Daknis, WP (reprint author), USA, Airborne Corps XVIII, Ft Bragg, NC USA. NR 70 TC 2 Z9 2 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2003 VL 177 BP 49 EP 109 PG 61 WC Law SC Government & Law GA 759NF UT WOS:000187743200003 ER PT J AU Morris, SW AF Morris, SW TI A survey of military retirement benefits SO MILITARY LAW REVIEW LA English DT Article C1 USA, Gen Litigat Branch, Litigat Div, Legal Serv Agcy, Arlington, VA USA. RP Morris, SW (reprint author), USA, Gen Litigat Branch, Litigat Div, Legal Serv Agcy, Arlington, VA USA. NR 6 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2003 VL 177 BP 133 EP 161 PG 29 WC Law SC Government & Law GA 759NF UT WOS:000187743200005 ER PT J AU Lawson, EK AF Lawson, EK TI The officer promotion re-look process: A practitioner's guide to special selection boards SO MILITARY LAW REVIEW LA English DT Article AB As a legal assistance attorney at a small Army installation, you are scheduled to meet with three officers recently nonselected for promotion: Captain Latoer, Major Correction, and Lieutenant Colonel Leftout. Each officer is seeking advice on his or her promotion re-look options. Since you are unfamiliar with this issue, you scan your Basic Course materials frantically looking for any relevant information to help you assist them. You find nothing. Do not panic; this article can help. C1 USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Lawson, EK (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2003 VL 177 BP 184 EP 212 PG 29 WC Law SC Government & Law GA 759NF UT WOS:000187743200007 ER PT J AU Bacon, BL Staudenmeier, JJ AF Bacon, BL Staudenmeier, JJ TI A historical overview of combat stress control units of the US Army SO MILITARY MEDICINE LA English DT Article ID OPERATION SEA SIGNAL; SOMALIA; SUPPORT; MISSION AB Combat stress control units have been deployed to the Gulf War, Somalia, Haiti, Guantanamo Bay, Bosnia, and Kosovo. They have been very flexible and useful mental health tools for commanders in both combat and peacekeeping operations for the past decade. In their operational role they have been effective, but their garrison mission remains unclear. This article summarizes the uses, missions, and lessons learned from the various combat stress control missions around the world. C1 Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. RP Bacon, BL (reprint author), Tripler Army Med Ctr, Dept Psychiat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 18 TC 8 Z9 12 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2003 VL 168 IS 9 BP 689 EP 693 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 740LH UT WOS:000186403500001 PM 14529239 ER PT J AU Piotroski, SS Chapin, MG AF Piotroski, SS Chapin, MG TI Human immunodeficiency virus social work program at the Walter Reed Army Medical Center: A historical perspective SO MILITARY MEDICINE LA English DT Article AB Human immunodeficiency virus (HIV) infection has become a pandemic concern for many nations. When this disease first presented itself in a global manner in the early 1980s, it was accompanied by fear, denial, misunderstanding, social stigma, and a paucity of available support services. The U.S. Army was becoming increasingly aware of the potential impact HIV could have on the active forces. A tragic event involving the suicide of a young HIV-infected soldier resulted in the development of a comprehensive medical/psychosocial assessment and treatment program for HIV-infected service members and their families at the Walter Reed Army Medical Center. Social work services played an integral role in the development of this program as this profession has done historically in meeting other emerging needs of the military. Special attention is given to the unique psychosocial. issues and needs of the HIV-infected service member and the comprehensive and compassionate response of the military medical team with its significant social work contribution. C1 Walter Reed Army Med Ctr, Dept Social Work, Washington, DC 20307 USA. RP Piotroski, SS (reprint author), Walter Reed Army Med Ctr, Dept Social Work, 6900 Georgia Ave, Washington, DC 20307 USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2003 VL 168 IS 9 BP 698 EP 701 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 740LH UT WOS:000186403500003 PM 14529241 ER PT J AU McMurry, P Nolan, DL AF McMurry, P Nolan, DL TI Skip policy: Road to force health protection 2010 SO MILITARY MEDICINE LA English DT Article AB The 2010 Force Health Protection Capstone concept envisions a single level of theater hospitalization and a greater reliance on the strategic movement of casualties from the theater. A significant Force Health Protection implication is 100% of the combat zone patients leaving theater will not have a second stay at an echelon/level IV hospital. In 2000, the Army began moving toward the Force Health Protection concept by using a skip policy for determining 2007 medical force structure requirements. Implementing the skip policy avoids (eliminates) the second echelon/level IV hospital length of stay for a percentage of combat zone patients leaving theater. The Army's decision to implement a skip policy exposed the complexities associated with determining deployable medical force structure requirements and the inherent inter-relatedness of the services medical mission. C1 USA, Med Dept Ctr & Sch, Struct & Anal Branch, Ft Sam Houston, TX 78234 USA. RP McMurry, P (reprint author), USA, Med Dept Ctr & Sch, Struct & Anal Branch, Ft Sam Houston, TX 78234 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2003 VL 168 IS 9 BP 702 EP 705 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 740LH UT WOS:000186403500004 PM 14529242 ER PT J AU Aberle, CJ Bethards, KJ Orsega, SM Ricciardi, R AF Aberle, CJ Bethards, KJ Orsega, SM Ricciardi, R TI Designing a Medical Humanitarian Assistance Course for advanced practice nurses in the uniformed services SO MILITARY MEDICINE LA English DT Article ID MISSIONS AB The U.S. uniformed services frequently respond to natural and man-made disasters worldwide. Disaster management and humanitarian assistance has been a major focus of military medicine for well over a decade. Training for these missions is a priority for the U.S. military, specifically as a result of the Gulf War. The Medical Humanitarian Assistance Course for advanced practice nurses is a course available to train advanced practice nurses in disaster management and humanitarian assistance. This article will describe the evolution, design, format, and implementation of the Medical Humanitarian Assistance Course. C1 Brooke Army Med Ctr, Family Med Serv, Ft Sam Houston, TX 78234 USA. Raymond W Bliss Hlth Ctr, Dept Mil Med, Ft Huachuca, AZ 85613 USA. NIH, Ctr Clin, Serv Nursing Dept, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Kimbrough Army Community Hosp, Ft George G Meade, MD 20755 USA. RP Aberle, CJ (reprint author), Brooke Army Med Ctr, Family Med Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2003 VL 168 IS 9 BP 729 EP 732 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 740LH UT WOS:000186403500010 PM 14529248 ER PT J AU Mangelsdorff, AD Finstuen, K AF Mangelsdorff, AD Finstuen, K TI Patient satisfaction in military medicine: Status and an empirical test of a model SO MILITARY MEDICINE LA English DT Article ID SYMPTOMS; THERAPY; CARE AB The Department of Defense (DoD) is concerned about how well military medical treatment facilities in the military health system perform. Patient expectations, attitudes, and health care use have been examined in numerous studies; the results are fairly consistent. Eligible beneficiaries report moderate satisfaction with the health care received. In 1994-2001, annual DoD and monthly ambulatory patient surveys were conducted in military medical treatment facilities. The DoD surveys document how patients perceive the care provided. The obvious research concerns are: requirements for conducting surveys; who should be surveyed: eligible beneficiaries or actual users; when; where; representative sample; how often to conduct assessment; data collection methods; analytic schemes; overall trends; predictors of satisfaction; use of results; and timeliness of findings. This study examines these issues and analyzes raw data from selected annual DoD and monthly ambulatory surveys. The overall level of perceived satisfaction has been "good" over the years surveys were used. The model demonstrated the use of examining demographic and attitudinal components of patient satisfaction in military medical facilities. C1 USA, Med Dept Ctr, USA Baylor Univ Grad Program Hlth Care Adm, Ft Sam Houston, TX 78234 USA. RP Mangelsdorff, AD (reprint author), USA, Med Dept Ctr, USA Baylor Univ Grad Program Hlth Care Adm, MCCS HFB 3151 Scott Rd, Ft Sam Houston, TX 78234 USA. NR 20 TC 7 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2003 VL 168 IS 9 BP 744 EP 749 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 740LH UT WOS:000186403500013 PM 14529251 ER PT J AU Claybaugh, JR Sato, AK VanScoy, SC AF Claybaugh, JR Sato, AK VanScoy, SC TI Effects of FiO(2) on O(2) consumption and cardiovascular and hormonal responses to hemorrhage in the goat SO MILITARY MEDICINE LA English DT Article ID OXYGEN-THERAPY; HYPOVOLEMIA; HYPOXIA; STIMULATION; VASOPRESSIN; ANGIOTENSIN; RELEASE; SHOCK; DOGS; RATS AB This study was conducted to determine whether 100% FiO(2) during hemorrhage would improve maintenance of mean arterial blood pressure and to assess the cardiovascular, arginine vasopressin, and renin-angiotensin system roles in the response. This also allowed evaluation of FiO(2) effects on the baroreceptor control of these hormone systems. Six conscious female goats were hemorrhaged (0.5 mL.kg(-1).min(-1)) for 30 minutes, while breathing 11%, 21%, or 100% O(2). Mean arterial blood pressure was maintained only when the goats breathed 100% O(2). FiO(2) did not affect O(2) consumption or delivery during hemorrhage. Increases in renin and arginine vasopressin were equal or reduced with 100% FiO(2) and therefore did not contribute to the improved mean arterial blood pressure maintenance. Inspiration of 100% FiO(2) during hemorrhage, therefore, may improve perfusion pressure with no changes in 02 consumption or delivery. Also, 100% FiO(2) eliminated the negative correlation between both hormones and right atrial pressure, suggesting altered baroreceptor control of the hormones. C1 Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP Claybaugh, JR (reprint author), Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. NR 20 TC 2 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2003 VL 168 IS 9 BP 758 EP 764 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 740LH UT WOS:000186403500016 PM 14529254 ER PT J AU Baggett, MAJMR Kelly, MP Korenman, LM Ryan, LM AF Baggett, MAJMR Kelly, MP Korenman, LM Ryan, LM TI Neuropsychological deficits of a US army pilot following an anoxic event as a function of cardiac arrest SO MILITARY MEDICINE LA English DT Article ID MA HUANG; SUPPLEMENTS; EPHEDRINE AB Anoxic encephalopathy occurs as a result of cardiac arrest, respiratory distress, or carbon monoxide poisoning. This is a case report on the neuropsychological deficits of anoxia in an otherwise previously healthy 36-year-old male pilot. The patient was taking an over-the-counter supplement that included an herb called Ma Huang on the day of his cardiac arrest. Ma Huang is reported to potentially present an increased risk of cardiac infarctions and central nervous system dysfunctions. Several instances of death have been linked to Ma Huang. The patient produced a neuropsychological profile that evidenced impairments in executive functioning, memory, language, attention, intellectual and academic functioning, as well as motor speed and coordination, all of which are consistent with diffuse brain damage. This case adds to the body of literature documenting the physical and neuropsychological effects of anoxia, as well as the effects of ephedrine-based supplements, such as Ma Huang. C1 Walter Reed Army Med Ctr, Neuropsychol Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Def Vet Head Injury Program, Washington, DC 20307 USA. RP Baggett, MAJMR (reprint author), Walter Reed Army Med Ctr, Neuropsychol Serv, Washington, DC 20307 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2003 VL 168 IS 9 BP 769 EP 771 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 740LH UT WOS:000186403500018 PM 14529256 ER PT J AU Kumar, R Tyagi, R Parmar, VS Samuelson, LA Kumar, J Watterson, AC AF Kumar, Rajesh Tyagi, Rahul Parmar, Virinder S. Samuelson, Lynne A. Kumar, Jayant Watterson, Arthur C. TI Enzymatic synthesis of multi-component copolymers and their structural characterization SO MOLECULAR DIVERSITY LA English DT Article DE 1, omega-alkanediols; 1,6-hexanediol; 1,6-hexanediamine and 1,6-hexanedithiol; Candida antarctica lipase B; dimethyl 5-hydroxyisophthalate; enzymes; multi-component copolymers; poly (ethylene glycol); terpolymerization; transesterification AB The use of enzymes in synthetic applications has increased dramatically in the recent years and the field of polymer science is part of this trend. Synthesis of a variety of polymers using lipase catalyzed (Candida antarctica) polymerization reactions has led to a variety of new materials with interesting properties in our laboratories. This paper describes the synthesis of multi-component polyesters and mixed polymers having polyester and polyamide linkages under solvent-less conditions using Candida antarctica lipase B. The effect of a third component, i.e. a series of 1,omega-alkanediols (1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, 1,10-decanediol, 1,12-dodecanediol, 1,14-tetradecanediol and 1,16-hexadecanediol) on the copolymerization reaction of dimethyl 5-hydroxyisophthalate with poly(ethylene glycol 600) has been studied and the mechanism for the incorporation of the third component is proposed. We have also studied the effect of different functional groups during terpolymerization reaction of dimethyl 5-hydroxyisophthalatewith poly(ethylene glycol) by adding a third component having different functionalities ( 1,6-hexanediol, 1,6-hexanediamine or 1,6-hexanedithiol) and compared the effect of hydroxyl, amine and thiol groups on the polymerization reactions. C1 [Kumar, Rajesh; Parmar, Virinder S.; Watterson, Arthur C.] Univ Massachusetts, Dept Chem, Inst Nano Sci & Engn Technol, Lowell, MA 01854 USA. [Kumar, Rajesh; Tyagi, Rahul; Kumar, Jayant] Univ Massachusetts, Dept Chem & Phys, Ctr Adv Mat, Lowell, MA 01854 USA. [Tyagi, Rahul; Parmar, Virinder S.] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India. [Samuelson, Lynne A.] USA, Natick Soldier Ctr, Soldier & Biol Chem Command, Natick, MA 01760 USA. RP Watterson, AC (reprint author), Univ Massachusetts, Dept Chem, Inst Nano Sci & Engn Technol, Lowell, MA 01854 USA. EM Arthur_Watterson@uml.edu NR 24 TC 12 Z9 12 U1 0 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1381-1991 J9 MOL DIVERS JI Mol. Divers. PD SEP PY 2003 VL 6 IS 3-4 BP 287 EP 295 PG 9 WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Medicinal; Chemistry, Multidisciplinary SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA V06TH UT WOS:000207215400017 PM 15068093 ER PT J AU Szebeni, J Baranyi, L Savay, S Milosevits, J Chanan-Khan, AA Liebes, L Muggia, FM Barenholz, Y Bunger, R Alving, CR AF Szebeni, J Baranyi, L Savay, S Milosevits, J Chanan-Khan, AA Liebes, L Muggia, FM Barenholz, Y Bunger, R Alving, CR TI Complement activation underlying pseudoallergic drug reactions SO MOLECULAR IMMUNOLOGY LA English DT Meeting Abstract CT 9th European Meeting on Complement in Human Disease CY SEP 06-09, 2003 CL TRIESTE, ITALY DE pseudoallergy; drug reactions ID HYPERSENSITIVITY; LIPOSOMES C1 Walter Reed Army Inst Res, Dept Membrane Biochem, Silver Spring, MD USA. NYU, Med Ctr, Kaplan Comprehens Canc Ctr, New York, NY USA. Hebrew Univ Jerusalem, Hadassah Med Sch, Lab Membrane & Liposome Res, IL-91010 Jerusalem, Israel. Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD SEP PY 2003 VL 40 IS 2-4 BP 180 EP 180 PG 1 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA 715MJ UT WOS:000184975900031 ER PT J AU Szebeni, J Baranyi, L Savay, S Gotze, O Alving, CR Bunger, R Mongan, PD AF Szebeni, J Baranyi, L Savay, S Gotze, O Alving, CR Bunger, R Mongan, PD TI Complement activation during hemorrhagic shock and resuscitation in swine SO MOLECULAR IMMUNOLOGY LA English DT Meeting Abstract CT 9th European Meeting on Complement in Human Disease CY SEP 06-09, 2003 CL TRIESTE, ITALY DE lactic acidosis; hemorhagic shock C1 Walter Reed Army Inst Res, Dept Membrane Biochem, Silver Spring, MD USA. Vaccine & Immunol Res Inst, Washington, DC USA. Univ Gottingen, D-3400 Gottingen, Germany. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD SEP PY 2003 VL 40 IS 2-4 BP 190 EP 190 PG 1 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA 715MJ UT WOS:000184975900051 ER PT J AU Veerappan, G Lettieri, C Cuneo, B AF Veerappan, G Lettieri, C Cuneo, B TI Squamous cell lung cancer presenting as a malar mass SO NEOPLASIA LA English DT Article DE lung carcinoma; metastatic; malar; face; non small cell lung cancer ID METASTASIS; CARCINOMA AB Introduction: Lung cancer metastasizing to the face has rarely been reported and is an even more unusual presentation. Case: This is the case of a 49-year-old man diagnosed with squamous cell carcinoma of the face, scheduled for resection. Preoperative radiographs revealed a left upper lobe mass, found to be squamous cell carcinoma. Diagnosis was changed to Stage IV primary lung cancer. The patient did not undergo resection. Discussion: No previous cases of primary lung cancer presenting as a malar mass have been reported. Facial lesions can be the presenting feature of primary lung cancer. Discovery of the true primary lesion can alter therapy and prognosis. C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Lettieri, C (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 6 TC 4 Z9 4 U1 0 U2 0 PU NEOPLASIA PRESS PI ANN ARBOR PA 1150 W MEDICAL CENTER DR, MSRB III, RM 9303, ANN ARBOR, MI 48109-0648 USA SN 1522-8002 J9 NEOPLASIA JI Neoplasia PD SEP-OCT PY 2003 VL 5 IS 5 BP 467 EP 468 PG 2 WC Oncology SC Oncology GA 745ZW UT WOS:000186722400010 PM 14670184 ER PT J AU Hord, ED Cohen, SP Cosgrove, GR Ahmed, SU Vallejo, R Chang, YC Stojanovic, MP AF Hord, ED Cohen, SP Cosgrove, GR Ahmed, SU Vallejo, R Chang, YC Stojanovic, MP TI The predictive value of sympathetic block for the success of spinal cord stimulation SO NEUROSURGERY LA English DT Article DE causalgia; complex regional region pain syndrome; reflex sympathetic dystrophy; spinal cord stimulation; sympathetic block ID REGIONAL PAIN SYNDROME; IASP DIAGNOSTIC-CRITERIA; SUBSTANCE-P; DYSTROPHY; MECHANISMS; MANAGEMENT; RELIEF; EXPERIENCE; RESPONSES; NEURONS AB Objective: The purpose of this study was to assess the predictive value of response to sympathetic blockade (SB) on the success rate of spinal cord stimulation (SCS) in patients with complex regional pain syndrome. Methods: We performed a retrospective study on 23 patients with complex regional pain syndrome who underwent both SB and subsequent SCS trials in the past 3 years at the Massachusetts General Hospital Pain Center, Boston, MA, and Walter Reed Army Medical Center, Washington, DC. Fifteen of these patients underwent permanent placement of an SCS device, and pain relief at 1- and 9-month follow up was recorded. Results: Among the 23 patients included in the study, those having transient pain relief with SB were more likely to have a positive SCS trial: all 13 with positive SB had good pain relief during the trial, compared with only 3 of the 10 with negative SB (100% versus 30%, p < 0.001). Among the 10 patients with negative SB, 7 noted poor pain relief during the trial despite adequate coverage, and they did not undergo placement of a permanent device. Among the patients who underwent permanent placement of the SCS device, those who received good pain relief with SB were more likely to have greater than 50% pain relief at 1 month follow-up (100% versus 33%, p = 0.029) and 9-month follow-up (87.5% versus 33.3%, P = 0.15). Conclusion: We conclude that patients with good response to SB before SCS are more likely to have a positive response during their SCS trial and long-term pain relief after placement of permanent SCS device. C1 Massachusetts Gen Hosp, MGH Pain Ctr, Intervent Pain Program, Dept Anesthesia, Boston, MA 02114 USA. Massachusetts Gen Hosp, MGH Pain Ctr, Intervent Pain Program, Dept Crit Care & Neurol, Boston, MA 02114 USA. Harvard Univ, Sch Med, Boston, MA 02115 USA. Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Pain Management Ctr, Dept Anesthesia, Washington, DC USA. Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA. Massachusetts Gen Hosp, MGH Pain Ctr, Dept Crit Care, Boston, MA 02114 USA. Massachusetts Gen Hosp, Med Practices Evaluat Ctr, Boston, MA 02114 USA. RP Hord, ED (reprint author), Massachusetts Gen Hosp, MGH Pain Ctr, Intervent Pain Program, Dept Anesthesia, WACC-324,15 Parkman St, Boston, MA 02114 USA. NR 33 TC 14 Z9 16 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD SEP PY 2003 VL 53 IS 3 BP 626 EP 632 DI 10.1227/01.NEU.0000080061.26321.8D PG 7 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 718AL UT WOS:000185122900021 PM 12943579 ER PT J AU Foster, JR Shaff, SE AF Foster, JR Shaff, SE TI Forest colonization of puget lowland grasslands at Fort Lewis, Washington SO NORTHWEST SCIENCE LA English DT Article ID PRAIRIE; WOODLAND; CONSEQUENCES; CONVERSION; VEGETATION; VIRGINIANA; INVASION; DYNAMICS; SAVANNA; USA AB As a result of fire exclusion since the mid-19th century, Douglas-fir has been invading the grasslands of the southern Puget Lowland, Washington, converting them to colonization forests. We studied a chronosequence of these forests, including some that received periodic commercial thinnings, at Fort Lewis Military Reservation to elucidate successional patterns and changes in ecosystem properties associated with tree invasion. In unmanaged colonization forests (ages 27-120 yr), overstory cover and tree density remained constant after 27 yr, while basal area increased. Shrub cover increased with age and, after an initial decrease compared to grasslands, ground cover also increased. Shrub species richness increased over time, while ground-layer richness was much less than in grasslands, and there was a rapid shift from grassland to forest floras. Dead wood (snags and logs) accumulated gradually. The only change in soil properties was lower A-horizon nitrogen. In managed colonization forests (ages 55-91 yr), tree density, overstory cover, and total log length decreased over time, but shrub cover and A-horizon cation-exchange capacity, carbon, and nitrogen increased over time. Although structural and floristic conversion of grassland to forest requires < 30 yr, soil changes are much more gradual, such that the soils underlying colonization forests up to 400 yr old are still classified as grassland soils. Higher tree densities in colonization forests compared to the pre-settlement forests of Fort Lewis mean an increased risk of crown fires during droughts. Even with active management, colonization forests will require many decades to provide northern spotted owl habitat because they lack shade-tolerant conifers and large live trees, snags, and logs. C1 USA, Forestry Program, Publ Works, AFZH,PWE, Ft Lewis, WA 98433 USA. RP Foster, JR (reprint author), USA, Forestry Program, Publ Works, AFZH,PWE, Ft Lewis, WA 98433 USA. NR 35 TC 17 Z9 18 U1 0 U2 6 PU WASHINGTON STATE UNIV PI PULLMAN PA PO BOX 645020, PULLMAN, WA 99164-5910 USA SN 0029-344X J9 NORTHWEST SCI JI Northwest Sci. PD FAL PY 2003 VL 77 IS 4 BP 283 EP 296 PG 14 WC Ecology SC Environmental Sciences & Ecology GA 754EF UT WOS:000187289200002 ER PT J AU Blaydon, SM Shepler, TR Neuhaus, RW White, WL Shore, JW AF Blaydon, SM Shepler, TR Neuhaus, RW White, WL Shore, JW TI The porous polyethylene (Medpor) spherical orbital implant - A retrospective study of 136 cases SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID HIGH-DENSITY POLYETHYLENE; FIBROVASCULAR INGROWTH; CORALLINE HYDROXYAPATITE; ANOPHTHALMIC SOCKET; TISSUE BREAKDOWN; BONE-GROWTH; EXPERIENCE; COMPLICATIONS; EVISCERATION; ENUCLEATION AB Purpose: To evaluate complications and risk factors associated with the placement of wrapped and unwrapped porous polyethylene (PP) spherical implants after evisceration, enucleation, or secondary implantation. Methods: A retrospective, interventional, noncomparative case series of consecutive cases of PP implant placement after anophthalmic socket surgery performed by three surgeons over a 5-year period. A PP spherical implant was placed in 133 patients, 61 women (2 bilaterally) and 72 men (I bilaterally). There were 91 enucleations, 30 eviscerations, and 15 secondary implant placements. Sixty-six (48.5%) implants were wrapped prior to placement. Parameters evaluated included: age, sex, prior ocular surgery or radiation treatment, indications for surgery, procedure performed, size of PP sphere, material used to wrap the implant, and complications. Results: A total of 17 of 136 (12.5%) cases had documented postoperative complications, with implant exposure being the most common. In 5 patients (3.7%), implant exposure developed: I after evisceration and 4 after primary enucleation. Three of the five exposures were small and resolved with either observation alone or in one case with surgical revision of the socket. In two cases, the exposures were large enough that removal of the implant was indicated, one after evisceration and the other after enucleation with placement of a wrapped PP sphere. Conclusions: Our series revealed no significant difference in exposure rate between wrapped and unwrapped PP sphere implants, nor was the exposure rate affected by whether an eye was eviscerated or enucleated. C1 Texas Oculoplast Consultants, Austin, TX 78705 USA. Univ Texas, Hlth Sci Ctr, Dept Ophthalmol, San Antonio, TX 78284 USA. USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. Brooke Army Med Ctr, Ophthalmol Serv, San Antonio, TX USA. Brackenridge Hosp, Cent Texas Med Fdn, Austin, TX USA. Univ Missouri, Sch Med, Dept Ophthalmol, Kansas City, MO 64108 USA. RP Shore, JW (reprint author), Texas Oculoplast Consultants, Austin Med Pl,3705 Med Pkwy,Suite 120, Austin, TX 78705 USA. NR 32 TC 62 Z9 68 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0740-9303 J9 OPHTHALMIC PLAST REC JI Ophthalmic Plast. Reconstr. Surg. PD SEP PY 2003 VL 19 IS 5 BP 364 EP 371 DI 10.1097/01.IOP.0000083643.36461.84 PG 8 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 726GQ UT WOS:000185590900007 PM 14506421 ER PT J AU Hutchinson, BA Galbraith, RL Stann, BL Der, SZ AF Hutchinson, BA Galbraith, RL Stann, BL Der, SZ TI Simulation-based analysis of range and cross-range resolution requirements for the identification of vehicles in ladar imagery SO OPTICAL ENGINEERING LA English DT Article DE automatic target recognition; ladar sensor simulation; object recognition; ladar ID AUTOMATIC TARGET RECOGNITION; OPTICAL-RADAR; SYSTEM AB We analyze the number and range accuracy of pixels required to distinguish vehicle types in ladar imagery. A simulation is used to generate large numbers of synthetic ladar images of a set of vehicles, and an automated geometry-matching algorithm used to identify vehicles is presented with each of these images. By systematically varying the range resolution, cross-range resolution, and other parameters, we can estimate joint ladar-algorithm system performance as a function of the sensor parameters. The results of these studies will provide guidance to ladar researchers and designers in setting fundamental system parameters for specific applications or operational scenarios. We describe the simulation, identification algorithm, and experimental results. (C) 2003 Society of Photo-Optical Instrumentation Engineers. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Hutchinson, BA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 11 TC 11 Z9 11 U1 0 U2 2 PU SPIE-INT SOCIETY OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD SEP PY 2003 VL 42 IS 9 BP 2734 EP 2745 DI 10.1117/1.1599837 PG 12 WC Optics SC Optics GA 721AX UT WOS:000185295800039 ER PT J AU Chan, AL Der, SZ Nasrabadi, NM AF Chan, AL Der, SZ Nasrabadi, NM TI Multistage infrared target detection SO OPTICAL ENGINEERING LA English DT Article DE target recognition; target detection; clutter rejection; FLIR imagery; feature extraction; generalized Hebbian algorithm; multilayer perceptron ID NEURAL-NETWORK; RECOGNITION; CLUTTER; CONTEXT; IMAGES; SYSTEM AB Algorithms are considered for searching wide-area forward-looking infrared imagery for military vehicles. Wide-area search has typically been handled by using a simple detection algorithm with low computational cost to search the entire image or set of images, followed by a clutter rejection algorithm that analyzes only those portions of the image that are marked by the detection algorithm. We start with a feature-based detector and an eigen-neural-based clutter rejecter, and examine a number of architectures for combining these modules to maximize joint performance. The architectures considered include a clutter rejection threshold method and a nonlinear learning-based combination. The performance of the architectures is compared using a set of several thousand real images. (C) 2003 Society of Photo-Optical Instrumentation Engineers. C1 USA, Res Lab, Attn AMSRL SE SE, Adelphi, MD 20783 USA. RP Chan, AL (reprint author), USA, Res Lab, Attn AMSRL SE SE, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 31 TC 11 Z9 12 U1 0 U2 1 PU SPIE-INT SOCIETY OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD SEP PY 2003 VL 42 IS 9 BP 2746 EP 2754 DI 10.1117/1.1593038 PG 9 WC Optics SC Optics GA 721AX UT WOS:000185295800040 ER PT J AU Zubko, E Shkuratov, Y Hart, M Eversole, J Videen, G AF Zubko, E Shkuratov, Y Hart, M Eversole, J Videen, G TI Backscattering and negative polarization of agglomerate particles SO OPTICS LETTERS LA English DT Article ID DISCRETE-DIPOLE APPROXIMATION; LIGHT-SCATTERING; SPHERES; CLUSTERS; MATRICES; GRAINS AB We used the discrete dipole approximation to study the backscattering of agglomerate particles consisting of oblong monomers. We varied the aspect ratio of the monomers from approximately 1 (sphere) to 4, while we kept the total particle volume equivalent to that of an x = 10 sphere for m = 1.59 + i0 and 1.50 + i0 and considered two values of agglomerate packing density: rho = 0.25 and rho = 0.1. We found that these particles do not display a prominent brightness opposition effect but do produce significant negative polarization over a range of near-backscattering angles. Increasing the monomers' aspect ratio can make the negative polarization much more prominent. We have noted also that decreasing m and p can reduce the amplitude of the negative polarization for these particles. (C) 2003 Optical Society of America. C1 Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. Natl Acad Sci Ukraine, Inst Radio Astron, UA-61022 Kharkov, Ukraine. USN, Res Lab, Washington, DC 20375 USA. USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. RP Zubko, E (reprint author), Kharkov Natl Univ, Inst Astron, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM guideen@arl.army.mil NR 21 TC 44 Z9 44 U1 1 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD SEP 1 PY 2003 VL 28 IS 17 BP 1504 EP 1506 DI 10.1364/OL.28.001504 PG 3 WC Optics SC Optics GA 713CB UT WOS:000184836900002 PM 12956360 ER PT J AU Issa, MA Patton, TA Abdalla, HA Yousif, AA Issa, MA AF Issa, MA Patton, TA Abdalla, HA Yousif, AA Issa, MA TI Composite behavior of shear connections in full-depth precast concrete bridge deck panels on steel stringers SO PCI JOURNAL LA English DT Article DE bridges; composite action; connections; deck panels; research; precast concrete; push-out specimens; shear connections; shear strength; shear studs; studs AB In this research, a total of 28 full-scale and quarter-scale push-out specimens were subjected to static loading. Each quarter-scale specimen was composed of a steel beam and two quarter-scale precast panels; each full-scale specimen comprised a steel beam and two full-scale precast panels. Precast panels were attached to the top flange of the steel beam using welded studs. Beam haunches of 3/8 and I in. (10 and 25 mm) filled with non-shrink grout material were provided for the quarter-scale and full-scale specimens, respectively. Two study parameters were considered. the number of pockets and the number of shear studs per pocket. Results revealed a trend in increased horizontal shear strength with respect to the number of studs or pockets; however, the increase in load capacity per stud was not proportional to the number of studs in the shear pocket. In addition, the finite element analysis results were comparable to the experimental results in terms of ultimate load and slippage. C1 Univ Illinois, Dept Civil & Mat Engn, Chicago, IL 60612 USA. USA Corps Engineers, Northbrook, IL USA. Alfred Benesch & Co, Chicago, IL USA. TY Lin Int, Chicago, IL USA. RP Issa, MA (reprint author), Univ Illinois, Dept Civil & Mat Engn, Chicago, IL 60612 USA. NR 18 TC 4 Z9 4 U1 2 U2 2 PU PRECAST/PRESTRESSED CONCRETE INST PI CHICAGO PA 175 W JACKSON BLVD, CHICAGO, IL 60604 USA SN 0887-9672 J9 PCI J JI PCI J. PD SEP-OCT PY 2003 VL 48 IS 5 BP 76 EP + PG 15 WC Construction & Building Technology SC Construction & Building Technology GA 735TD UT WOS:000186129900007 ER PT J AU Waasdorp, CE Rooks, V Sullivan, C AF Waasdorp, CE Rooks, V Sullivan, C TI Congenital microgastria presenting as stridor SO PEDIATRIC RADIOLOGY LA English DT Letter C1 Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Waasdorp, CE (reprint author), Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD SEP PY 2003 VL 33 IS 9 BP 662 EP 663 DI 10.1007/s00247-003-0953-2 PG 2 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA 712XQ UT WOS:000184825200018 PM 12811434 ER PT J AU Rotenberg, JS Newmark, J AF Rotenberg, JS Newmark, J TI Nerve agent attacks on children: Diagnosis and management SO PEDIATRICS LA English DT Review DE chemical warfare agents; terrorism; organophosphorus compounds; sarin; atropine; benzodiazepines; pralidoxime compounds; all children (0-18 years of age) ID CHRONIC NEUROLOGICAL SEQUELAE; REFRACTORY STATUS EPILEPTICUS; SUBWAY SARIN ATTACK; BLOOD-BRAIN-BARRIER; TOKYO SUBWAY; MUSCARINIC RECEPTORS; ORGANO-PHOSPHATE; ORGANOPHOSPHATE INTOXICATION; ORAL CHLORPYRIFOS; PARAOXONASE PON1 AB Nerve agents (NAs) are the most lethal chemical weapons. We review the pathophysiology and management of NA poisoning of children. NAs cause cholinergic crisis. Children may manifest signs of cholinergic poisoning differently than adults. Children may be less likely to manifest miosis and glandular secretions. They may present with neurologic derangements alone. The goals of treatment should be to limit additional exposure, to provide respiratory support, and to prevent neurologic morbidity. Autoinjectors are optimal delivery vehicles for intramuscular antidotes and are likely to be used in civilian prehospital care. Antidotes include anticholinergics, oximes, and benzodiazepines. Several medications may be available within each class of antidotes. Clinicians will select an antidote based on the status of the individual victim, the accessibility of supportive care, and the availability of the drug. Atropine is well-tolerated and high doses may be required. The oxime pralidoxime chloride has a longer half-life in children. Currently, diazepam is the standard NA anticonvulsant. Midazolam may be the most effective intramuscular anticonvulsant after NA exposure, but, despite its efficacy, it is not an approved agent for seizures. Supportive care and long-term complications are summarized. C1 Walter Reed Army Med Ctr, Dept Child & Adolescent Neurol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. USA, Med Res Inst Chem Def, Chem Casualty Care Div, Aberdeen Proving Ground, MD 21010 USA. RP Rotenberg, JS (reprint author), Walter Reed Army Med Ctr, Dept Child & Adolescent Neurol, MCHL-MR,Bldg 2,Rm 1L,6900 Georgia Ave NW, Washington, DC 20307 USA. NR 87 TC 45 Z9 45 U1 1 U2 7 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD SEP PY 2003 VL 112 IS 3 BP 648 EP 658 DI 10.1542/peds.112.3.648 PG 11 WC Pediatrics SC Pediatrics GA 716NL UT WOS:000185035100041 PM 12949297 ER PT J AU Munavalli, S Rohrbaugh, DK Durst, HD AF Munavalli, S Rohrbaugh, DK Durst, HD TI An unusual reaction of dimethyl azodicarboxylate with H-dimethylphosphonate SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE CI characterization; diethyl azodicarboxylate; free radical participation; CTC-MS-EI; H-dimethylphosphonate; Mitsunobu reaction; novel compounds ID MITSUNOBU ESTERIFICATION REACTION; DIETHYL-AZODICARBOXYLATE; BETA-LACTAMS; TRIPHENYLPHOSPHINE; ACIDS; PHOSPHONATE; PHOSPHITES; MECHANISM; AMINATION; OXIDATION AB When the commonly used phosphorus components of the cocktail of the classical Mitsunobo reaction are changed from triphenylphosphine and trialkylphosphite to H-dimethylphosphonate, the course of the reaction changes and leads to products arising from the involvement of the free radical reaction. This article presents the mass spectral characterization of the novel compounds along with the probable mechanism of their formation. C1 Geocenters Inc, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Munavalli, S (reprint author), Geocenters Inc, Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. NR 49 TC 2 Z9 2 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PD SEP PY 2003 VL 178 IS 9 BP 1871 EP 1879 DI 10.1080/10426500390220998 PG 9 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 727TX UT WOS:000185677900003 ER PT J AU Bujnicki, JM Prigge, ST Caridha, D Chiang, PK AF Bujnicki, JM Prigge, ST Caridha, D Chiang, PK TI Structure, evolution, and inhibitor interaction of S-adenosyl-L-homocysteine hydrolase from Plasmodium falciparum SO PROTEINS-STRUCTURE FUNCTION AND GENETICS LA English DT Article DE malaria; protein-ligand interactions; homology modeling; molecular phylogenetics ID ADENOSYLHOMOCYSTEINE HYDROLASE; CRYSTAL-STRUCTURE; RAT-LIVER; SEQUENCE; ADENOSYLMETHIONINE; METHYLATION; GENERATION; GENOME; ENZYME; GENE AB S-adenosylhomocysteine hydrolase (SAHH) is a key regulator of S-adenosylmethionine-dependent methylation reactions and an interesting pharmacologic target. We cloned the SAHH gene from Plasmodium falciparum (PfSAHH), with an amino acid sequence agreeing with that of the PlasmoDB genomic database. Even though the expressed recombinant enzyme, PfSAHH, could use 3-deaza-adenosine (DZA) as an alternative substrate in contrast to the human SAHH, it has a unique inability to substitute 3-deaza-(+/-)aristeromycin (DZAri) for adenosine. Among the analogs of DZA, including neplanocin A, DZAri was the most potent inhibitor of the PfSAHH enzyme activity, with a K-i of about 150nM, whether Ado or DZA was used as a substrate. When the same DZA analogs were tested for their antimalarial activity, they also inhibited the in vitro growth of P. falciparum parasites potently. Homology-modeling analysis revealed that a single substitution (Thr60-Cys59) between the human and malarial PfSAHH, in an otherwise similar SAH-binding pocket, might account for the differential interactions with the nucleoside analogs. This subtle difference in the active site may be exploited in the development of novel drugs that selectively inhibit PfSAHH. We performed a comprehensive phylogenetic analysis of the SAHH superfamily and inferred that SAHH evolved in the common ancestor of Archaea and Eukaryota, and was subsequently horizontally transferred to Bacteria. Additionally, an analysis of the unusual and uncharacterized AHCYL1 family of the SAHH paralogs extant only in animals reveals striking divergence of its SAH-binding pocket and the loss of key conserved residues, thus suggesting an evolution of novel function(s). (C) 2003 Wiley-Liss, Inc. C1 Int Inst Mol & Cell Biol, Bioinformat Lab, PL-02109 Warsaw, Poland. Walter Reed Army Inst Res, Silver Spring, MD USA. Johns Hopkins Bloomberg Sch Publ Hlth, Malaria Res Inst, Baltimore, MD USA. NICHHD, NIH, Bethesda, MD 20892 USA. RP Bujnicki, JM (reprint author), Int Inst Mol & Cell Biol, Bioinformat Lab, PL-02109 Warsaw, Poland. NR 27 TC 26 Z9 27 U1 0 U2 3 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0887-3585 J9 PROTEINS JI Proteins PD SEP 1 PY 2003 VL 52 IS 4 BP 624 EP 632 DI 10.1002/prot.10446 PG 9 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 715AC UT WOS:000184947400013 PM 12910461 ER PT J AU Jackson, JL Chamberlin, J Kroenke, K AF Jackson, JL Chamberlin, J Kroenke, K TI Gender and symptoms in primary care practices SO PSYCHOSOMATICS LA English DT Review ID PATIENT SATISFACTION; MENTAL-DISORDERS; COMMON SYMPTOMS; HOSPITAL-CARE; MEDICAL-CARE; PHYSICIAN; EXPECTATIONS; SOMATIZATION; PREVALENCE; SETTINGS AB The authors sought to explore gender differences among patients with physical symptoms who came to see internists. The women were younger more likely to report stress, endorsed more "other currently bothersome" symptoms, were more likely to have a mental disorder and were less likely to be satisfied with their care. The men were slower to improve, but there was no difference between the sexes after 3 months. There were no differences in the number type, duration, or severity of symptoms or in the expectation of care, costs of visits, intervention received use of health care services, or likelihood of being considered difficult by their physician. The gender of the clinician had no effect on any outcome. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Jackson, JL (reprint author), Med EDP, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 46 TC 11 Z9 11 U1 1 U2 3 PU AMER PSYCHIATRIC PRESS, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD SEP-OCT PY 2003 VL 44 IS 5 BP 359 EP 366 DI 10.1176/appi.psy.44.5.359 PG 8 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 717HF UT WOS:000185081100001 PM 12954909 ER PT J AU Armstrong, SC Cozza, KL AF Armstrong, SC Cozza, KL TI Med-psych drug-drug interactions update - Antihistamines SO PSYCHOSOMATICS LA English DT Article ID H-1 RECEPTOR ANTAGONISTS; CYP2D6 ACTIVITY; P-GLYCOPROTEIN; DESLORATADINE; DIPHENHYDRAMINE; FEXOFENADINE; DISPOSITION; LORATADINE; PHARMACOKINETICS; KETOCONAZOLE AB Antihistamines and their drug-drug interactions are reviewed in depth. The metabolism of "classic " or sedating antihistamines is coming to light through in vivo and in vitro studies. The polymorphic CYP 2D6 metabolic enzyme appears to be potently inhibited by many of these over-the-counter medications. The history of the discontinued "second-generation " antihistamines terfenadine and astemizole is reviewed to remind the reader why the understanding of the cytochrome P450 system became increasingly important when the cardiotoxicity of these drugs became apparent. The "third-generation " nonsedating antihistamines are also listed and compared. They have been exhaustively scrutinized for drug-drug interactions and cardiotoxicity, and they appear to have no serious drug-drug interactions at recommended doses. C1 Tual Forest Grove Hosp, Ctr Geriatr Psychiat, Forest Grove, OR 97116 USA. Oregon Hlth Sci Univ, Portland, OR 97201 USA. Walter Reed Army Med Ctr, Dept Med, Infect Dis Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Armstrong, SC (reprint author), Tual Forest Grove Hosp, Ctr Geriatr Psychiat, 1809 Maple St, Forest Grove, OR 97116 USA. NR 31 TC 12 Z9 13 U1 0 U2 1 PU AMER PSYCHIATRIC PRESS, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD SEP-OCT PY 2003 VL 44 IS 5 BP 430 EP 434 DI 10.1176/appi.psy.44.5.430 PG 5 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 717HF UT WOS:000185081100012 PM 12954920 ER PT J AU Cohen, SP Abdi, S AF Cohen, SP Abdi, S TI Sacroiliac joint pain: Should physicians be blocking lateral branches, medial branches, dorsal rami, or ventral rami? - Reply SO REGIONAL ANESTHESIA AND PAIN MEDICINE LA English DT Letter ID NEUROTOMY C1 NYU, Sch Med, Pain Management Ctr, Walter Reed Army Med Ctr, New York, NY 10012 USA. Univ Miami, Sch Med, Pain Management Ctr, Miami, FL USA. RP Cohen, SP (reprint author), NYU, Sch Med, Pain Management Ctr, Walter Reed Army Med Ctr, New York, NY 10012 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 1098-7339 J9 REGION ANESTH PAIN M JI Region. Anesth. Pain Med. PD SEP-OCT PY 2003 VL 28 IS 5 BP 490 EP 491 DI 10.1016/S1098-7339(03)00390-0 PG 2 WC Anesthesiology SC Anesthesiology GA 729BU UT WOS:000185751700029 ER PT J AU Helman, DL Sullivan, A Kariya, ST Deering, SH Hueppchen, NA Shorr, AF AF Helman, DL Sullivan, A Kariya, ST Deering, SH Hueppchen, NA Shorr, AF TI Management of idiopathic pulmonary haemosiderosis in pregnancy: Report of two cases SO RESPIROLOGY LA English DT Article DE alveolar haemorrhage; idiopathic pulmonary haemosiderosis; pregnancy ID HEMORRHAGE AB Idiopathic pulmonary haemosiderosis (IPH) is a rare cause of alveolar haemorrhage. Its management in pregnancy is complicated and little clinical data exist on outcomes or treatment. Two patients with IPH, one with a known diagnosis prior to pregnancy (patient A) and one presenting de novo during pregnancy (patient B) are reported. Both subjects became maximally symptomatic in the third trimester and were treated with corticosteroids. Despite steroid treatment patient A had continued symptoms and was treated with azathioprine. Both patients delivered healthy female infants at 32 weeks and 38 weeks gestation, respectively. Patient B's course was complicated by the development of fatal invasive pulmonary aspergillosis 4 weeks postpartum. With improved care, more patients with IPH survive to childbearing age. Patients become most symptomatic late in pregnancy, underscoring the need for careful third trimester monitoring. These cases demonstrate that steroids are safe and that azathioprine can be used as additional therapy. When considering treatment options it is important to weigh the benefits of these medications against the potential for maternal and foetal harm. C1 Walter Reed Army Med Ctr, Div Pulm Med, Dept Internal Med, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. Natl Naval Med Res Inst, Dept Obstet & Gynecol, Bethesda, MD USA. Univ Washington, Sch Med, Washington, DC USA. RP Helman, DL (reprint author), Walter Reed Army Med Ctr, Div Pulm Med, Dept Internal Med, Pulm & Crit Care Med Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM doctornole@aol.com NR 7 TC 6 Z9 7 U1 0 U2 0 PU BLACKWELL PUBLISHING ASIA PI CARLTON PA 54 UNIVERSITY ST, P O BOX 378, CARLTON, VICTORIA 3053, AUSTRALIA SN 1323-7799 J9 RESPIROLOGY JI Respirology PD SEP PY 2003 VL 8 IS 3 BP 398 EP 400 DI 10.1046/j.1440-1843.2003.00477.x PG 3 WC Respiratory System SC Respiratory System GA 726DL UT WOS:000185583100024 PM 14528889 ER PT J AU Severns, PM AF Severns, PM TI Propagation of a long-lived and threatened prairie plant, Lupinus sulphureus ssp kincaidii SO RESTORATION ECOLOGY LA English DT Article DE Fender's blue butterfly; grasslands; Kincaid's lupine; prairie restoration; seed scarification ID SMALL POPULATION-SIZE; SEED-GERMINATION; INBREEDING DEPRESSION; FABACEAE; RARE; SCARIFICATION; CONSERVATION; LOAD AB Willamette Valley upland prairie in western Oregon, U.S.A. has been severely degraded and fragmented in the past 150 years after European settlement, resulting in vast population reductions of endemic species. Icaricia icarioides fenderi (Fender's blue butterfly) and Lupinus sulphureus ssp. kincaidii (Kincaid's lupine) are federally listed as Endangered and Threatened Species, respectively. Both are Willamette Valley upland prairie endemics, and Kincaid's lupine is the primary host plant for the Fender's blue butterfly. Attempts to grow Kincaid's lupine have been partially successful in a greenhouse situation; however, propagating plants from field-sown seed can be tenuous and plant establishment is unpredictable. Kincaid's lupine seeds were planted in the fall 1997 at two different upland prairie sites, and the cohort was followed through the summer 2000. Based on cohort tables the most vulnerable life stages to mortality are the germinant stage and the first growing year. Mechanical scarification of Kincaid's lupine seeds yielded no significant differences in survivorship, maternal function, plant size, and the percentage of seeds germinated compared with unscarified seeds. Differential seed source performance detected at one planting site suggests that underlying differences in population genetics may affect Kincaid's lupine vigor, fitness, and establishment. Future restoration projects for Kincaid's lupine should focus on upland prairie sites with naturally occurring lupine populations because local ecological conditions are favorable for lupine establishment. Moreover, the addition of new individuals to small Kincaid's lupine colonies will buffer against the effects of inbreeding depression and increase the site carrying capacity for Fender's blue butterfly. C1 USA, Corps Engineers, Willamette Valley Projects, Lowell, OR 97452 USA. RP Severns, PM (reprint author), Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA. NR 40 TC 16 Z9 17 U1 7 U2 18 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 1061-2971 J9 RESTOR ECOL JI Restor. Ecol. PD SEP PY 2003 VL 11 IS 3 BP 334 EP 342 DI 10.1046/j.1526-100X.2003.00175.x PG 9 WC Ecology SC Environmental Sciences & Ecology GA 708NW UT WOS:000184575400009 ER PT J AU Hepburn, MJ Fraser, SL Rennie, TA Singleton, CM Delgado, B AF Hepburn, MJ Fraser, SL Rennie, TA Singleton, CM Delgado, B TI Septic arthritis caused by Granulicatella adiacens: diagnosis by inoculation of synovial fluid into blood culture bottles SO RHEUMATOLOGY INTERNATIONAL LA English DT Article DE Abiotrophia; Granulicatella; Granulicatella adiacens; knee; nutritionally deficient streptococcus; nutritionally variant streptococcus; septic arthritis ID NUTRITIONALLY VARIANT STREPTOCOCCI; ENDOCARDITIS; GROWTH; NOV AB Granulicatella species, formerly known as nutritionally variant streptococci, cause a variety of infections, primarily endocarditis. We report the first culture-proven case of a Granulicatella species causing septic arthritis. A 68-year-old female presented with knee pain and swelling. She was initially evaluated with arthrocentesis and arthroscopy, but no organism was identified. Her pain improved after a brief course of antibiotics but recurred 3 months later. She underwent repeat arthrocentesis, with direct inoculation of synovial fluid into blood culture bottles. Granulicatella adiacens was recovered from both bottles. She was treated with cefazolin for 4 weeks combined with gentamicin for the first 2 weeks. Her knee pain and swelling resolved without evidence of recurrence. Granulicatella should be considered in cases of septic arthritis with initially negative synovial fluid cultures. Inoculation of blood cultures bottles with synovial fluid may increase the diagnostic yield for these species. C1 Brooke Army Med Ctr, MCHE MDI 4 W, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Microbiol, Ft Sam Houston, TX 78234 USA. RP Hepburn, MJ (reprint author), Brooke Army Med Ctr, MCHE MDI 4 W, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 16 TC 22 Z9 25 U1 0 U2 0 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0172-8172 J9 RHEUMATOL INT JI Rheumatol. Int. PD SEP PY 2003 VL 23 IS 5 BP 255 EP 257 DI 10.1007/s00296-003-0305-4 PG 3 WC Rheumatology SC Rheumatology GA 722UG UT WOS:000185395000010 PM 12720043 ER PT J AU South, JT Case, SW Reifsnider, KL AF South, JT Case, SW Reifsnider, KL TI Effects of thermal aging on the mechanical properties of natural rubber SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article ID DOUBLE-CANTILEVER-BEAM AB The focus of this research was to investigate the effect of thermal degradation upon the mechanical properties of a natural rubber compound. We examined both the quasi-static and dynamic mechanical properties of a natural rubber vulcanizate which had been subjected to isothermal, anaerobic aging. The thermal aging was conducted between the temperatures of 80 degreesC and 120 degreesC for times ranging from 3 to 24 days. The effect of thermal degradation was measured using the changes in the crosslink distribution of the vulcanizates as functions of time at temperature. A master curve relationship between the crosslink distribution of the vulcanizates due to thermal degradation and the static and dynamic mechanical properties has been developed. It was found that the both the quasi-static and dynamic mechanical properties correlated with the percentage of poly and monosulfidic crosslinks, where in general higher levels of polysulfidic crosslink gave rise to the highest mechanical properties. C1 USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Mat Response Grp, Blacksburg, VA 24061 USA. RP South, JT (reprint author), USA, Ballist Res Lab, AMSRL,WM,MB Bldg 4600,C137, Aberdeen Proving Ground, MD 21005 USA. RI Case, Scott/C-2637-2009; OI Case, Scott/0000-0002-4802-1228 NR 21 TC 12 Z9 12 U1 0 U2 3 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 USA SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD SEP-OCT PY 2003 VL 76 IS 4 BP 785 EP 802 DI 10.5254/1.3547772 PG 18 WC Polymer Science SC Polymer Science GA 742QB UT WOS:000186528300003 ER PT J AU Godinez-Azcuaga, VF Finlayson, RD Ward, J AF Godinez-Azcuaga, VF Finlayson, RD Ward, J TI Acoustic techniques for the inspection of ballistic protective inserts in personnel armor SO SAMPE JOURNAL LA English DT Article AB This paper presents the results from a study performed to demonstrate the feasibility of using Guided Wave Acousto-Ultrasonics (GWAU) to assess the condition (as related to ballistic performance) of personnel armor Ballistic Protective Inserts (BPI). The BPI is manufactured with ceramic fiber reinforced plastic (FRP) composite technology. Experiments were performed on BPI damaged ballistically, by mishandling, and in the "as manufactured" condition. The data collected from these experiments were used to form manual and automated C-scan images. Both manual and automatic C-scans of the samples revealed clear differences between the damaged and undamaged samples. Also, RF signals were recorded from different locations on the samples damaged by mishandling, and a frequency analysis was preformed The results from this analysis revealed a good correlation with the actual degree of damage in the samples. C1 Phys Acoust Corp, Princeton Jct, NJ USA. USA, Natick Soldier Ctr, Natick, MA USA. RP Godinez-Azcuaga, VF (reprint author), Phys Acoust Corp, Princeton Jct, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAMPE PUBLISHERS PI COVINA PA 1161 PARKVIEW DRIVE, COVINA, CA 91722 USA SN 0091-1062 J9 SAMPE J JI Sampe J. PD SEP-OCT PY 2003 VL 39 IS 5 BP 8 EP 19 PG 12 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 713ZK UT WOS:000184887700002 ER PT J AU Zhang, HW Subhash, G Kecskes, LJ Dowding, RJ AF Zhang, HW Subhash, G Kecskes, LJ Dowding, RJ TI Mechanical behavior of bulk (ZrHf)TiCuNiAl amorphous alloys SO SCRIPTA MATERIALIA LA English DT Article DE nano-indentation; hardness; metallic glass; shear bands; mechanical properties; crystallization ID METALLIC-GLASS; NANOINDENTATION; DEFORMATION; INDENTATION; FLOW AB Experimental investigation of thermodynamic behavior and mechanical properties of bulk Zr/Hf-based amorphous alloys revealed that crystallization and glass transition temperatures, hardness and modulus increased with increasing Hf content. It is postulated that the observed strengthening might result from the microstructural changes with addition of Hf in place of Zr. (C) 2003 Acta Materialia Inc. Published by Elsevier Science Ltd. All rights reserved. C1 Michigan Technol Univ, Dept Mech Engn Engn Mech, Houghton, MI 49931 USA. Michigan Technol Univ, Dept Mat Sci & Engn, Houghton, MI 49931 USA. USA, Res Lab, Weapons & Mat Res Directorate, AMSRL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Subhash, G (reprint author), Michigan Technol Univ, Dept Mech Engn Engn Mech, 1400 Townsend Dr, Houghton, MI 49931 USA. RI Kecskes, Laszlo/F-6880-2014; Dowding, Robert/F-1469-2015 OI Kecskes, Laszlo/0000-0002-1342-3729; Dowding, Robert/0000-0002-4763-2131 NR 17 TC 10 Z9 10 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD SEP PY 2003 VL 49 IS 5 BP 447 EP 452 DI 10.1016/S1359-6462(03)00295-1 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 696VX UT WOS:000183909200016 ER PT J AU Crum, NF Wallace, MR Stephan, K Blazes, DL Aronson, N Tasker, SA Thomas, AG Wegner, S Casper, C Wald, A Corey, L Brodine, SK AF Crum, NF Wallace, MR Stephan, K Blazes, DL Aronson, N Tasker, SA Thomas, AG Wegner, S Casper, C Wald, A Corey, L Brodine, SK TI Correlates of human herpesvirus-8 seropositivity among US military members recently infected with human immunodeficiency virus SO SEXUALLY TRANSMITTED DISEASES LA English DT Article; Proceedings Paper CT 40th Annual Meeting of the Infectious-Diseases-Society-of-America CY OCT 24-27, 2002 CL CHICAGO, ILLINOIS SP Int Dis Soc Amer ID SARCOMA-ASSOCIATED HERPESVIRUS; KAPOSIS-SARCOMA; SEXUAL TRANSMISSION; RISK-FACTORS; SEROEPIDEMIOLOGY; MEN; WOMEN; SEROCONVERSION AB Background: Human herpesvirus 8 (HHV-8), the cause of Kaposi's sarcoma, is common among HIV-infected persons. The exact route of transmission of HHV-8 in various populations is still debated. Goal: The goal was to define the correlates of HHV-8 infection among men recently infected with human immunodeficiency virus. Study Design: Three hundred forty-two HIV-infected U.S. military men were evaluated using a questionnaire. regarding potential risk factors and laboratory data, including HHV-8, herpes simplex virus 2 (HSV-2), syphilis, hepatitis B, and hepatitis C serologies. Results: The seroprevalence of HHV-8 was 32%. HHV-8 was significantly associated with hepatitis B seropositivity (odds ratio [OR], 2.44; 95% confidence interval [CI], 1.5-4.1), and black ethnicity was negatively associated with HHV-8 (OR, 0.6; 95% Cl, 0.3-0.9) in the multivariate analysis. HHV-8 was not associated with drug use or hepatitis C seropositivity. Among men who have sex with men (MSM), HHV-8 infection correlated with hepatitis B seropositivity (OR, 2.2; 95% CI, 1.1-4.3) and HSV-2 (OR, 2.6; 95% CI, 1.4-4.9). Among heterosexuals, the correlates of HHV-8 were different; blacks as compared with whites (OR, 0.3; 95% Cl, 0.1-0.8) and married versus single status (OR, 0.4; 95% Cl, 0.2-0.9) were associated with a lower rate of HHV-8 infection. Among heterosexuals, hepatitis B, HSV-2, and sexual behaviors were not associated with HHV-8. Conclusion: This study suggests that the seroprevalence of HHV-8 is increased in both MSM and heterosexual men with HIV infection, and that the route(s) of HHV-8 acquisition might be different between MSM and heterosexuals. C1 USN, Med Ctr, Dept Med, Div Infect Dis, San Diego, CA USA. Wilford Hall USAF Med Ctr, Div Infect Dis, Lackland AFB, TX 78236 USA. Natl Naval Med Res Inst, Infect Dis Serv, Bethesda, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Div Infect Dis, Washington, DC 20307 USA. USN, Hlth Res Ctr, San Diego, CA 92152 USA. US Mil HIV Res Program, Rockville, MD USA. Univ Washington, Dept Med, Div Infect Dis, Seattle, WA USA. Univ Washington, Dept Med, Seattle, WA 98104 USA. Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA. Univ Washington, Dept Lab Med, Seattle, WA 98104 USA. Univ Washington, Fred Hutchinson Canc Res Ctr, Dept Med, Seattle, WA 98195 USA. Univ Washington, Fred Hutchinson Canc Res Ctr, Dept Lab Med, Seattle, WA 98195 USA. Univ Washington, Fred Hutchinson Canc Res Ctr, Program Infect Dis, Seattle, WA 98195 USA. RP Crum, NF (reprint author), USN, Med Ctr, Dept Clin Invest, KCA, 34800 Bob Wilson Dr,Suite 5, San Diego, CA 92134 USA. EM nfcrum@nmcsd.med.navy.mil RI Wald, Anna/B-6272-2012 OI Wald, Anna/0000-0003-3486-6438 FU NIAID NIH HHS [P01 AI-30731, U19 AI-31448] NR 18 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD SEP PY 2003 VL 30 IS 9 BP 713 EP 718 DI 10.1097/01.OLQ.0000078627.30743.4A PG 6 WC Infectious Diseases SC Infectious Diseases GA 719CB UT WOS:000185185100008 PM 12972795 ER PT J AU Polyakov, AY Govorkov, AV Smirnov, NB Pashkova, NV Pearton, SJ Overberg, ME Abernathy, CR Norton, DP Zavada, JM Wilson, RG AF Polyakov, AY Govorkov, AV Smirnov, NB Pashkova, NV Pearton, SJ Overberg, ME Abernathy, CR Norton, DP Zavada, JM Wilson, RG TI Properties of mn and co implanted ZnO crystals SO SOLID-STATE ELECTRONICS LA English DT Article ID MOLECULAR-BEAM EPITAXY; DOPED ZNO; FILMS AB Electrical properties, room temperature optical absorption bands and 300 and 90 K microcathodoluminescence (MCL) bands were studied in heavily Mn and Co implanted ZnO samples annealed at 700 C. Samples processed under the same conditions have previously shown ferromagnetic behavior. The Mn and Co implanted and annealed regions remain n-type and have a higher electron concentration than in control samples. Therefore, the spin alignment in ZnMnO and ZnCoO is not mediated by the classical mechanism involving free holes. Optical absorption bands near 1.9 eV (Co) and 2 eV (Mn) and the MCL bands near 1.84 eV (Co) and 1.89 eV (Mn) are found to be associated with transition metal (TM) ions. These bands are tentatively attributed to internal transitions between the levels of the substitutional TM ions. In addition to those TM ions related bands we also observed strong absorption bands at 0.75, 1.4, 2.35 and 2.5 eV and MCL bands near 2.3 and 2.5 eV. All these bands are related to radiation damage defects. (C) 2003 Elsevier Science Ltd. All rights reserved. C1 Inst Rare Met, Moscow 119017, Russia. Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Polyakov, AY (reprint author), Inst Rare Met, B Tolmachevsky 5, Moscow 119017, Russia. RI Smirnov, Nickolai/K-8935-2015 OI Smirnov, Nickolai/0000-0002-4993-0175 NR 15 TC 10 Z9 10 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD SEP PY 2003 VL 47 IS 9 BP 1523 EP 1531 DI 10.1016/S0038-1101-00083-2 PG 9 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 698TK UT WOS:000184014700016 ER PT J AU Overberg, ME Thaler, GT Frazier, RM Rairigh, R Kelly, J Abernathy, CR Pearton, SJ Hebard, AF Wilson, RG Zavada, JM AF Overberg, ME Thaler, GT Frazier, RM Rairigh, R Kelly, J Abernathy, CR Pearton, SJ Hebard, AF Wilson, RG Zavada, JM TI Ferromagnetism in Mn- and Cr-implanted AlGaP SO SOLID-STATE ELECTRONICS LA English DT Article ID ROOM-TEMPERATURE MAGNETISM; MOLECULAR-BEAM EPITAXY; ION-IMPLANTATION; P-GAN; SEMICONDUCTORS AB Implantation of Mn or Cr at doses of 3-5 x 10(16) cm(-2) into Si-doped Al0.24Ga0.76P epilayers on Gad substrates produced ferromagnetic ordering at temperatures up to 300 K. The results were similar to those obtained previously in p-type AlGaP(C), indicating that both electron and hole-doped AlGaP can exhibit ferromagnetism. In addition, the AlGaP results are similar to those for Gad so the magnitude of the bandgap was not the main parameter influencing the Curie temperature, in contradiction to predictions from some mean-field theories. Second phases were not observed by X-ray diffraction and were not responsible for the ferromagnetism. (C) 2003 Elsevier Science Ltd. All rights reserved. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Phys, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Overberg, ME (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. NR 19 TC 3 Z9 3 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD SEP PY 2003 VL 47 IS 9 BP 1549 EP 1552 DI 10.1016/S0038-1101(03)00098-4 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 698TK UT WOS:000184014700020 ER PT J AU Ellzy, MW Jensen, JO Hameka, HF Kay, JG AF Ellzy, MW Jensen, JO Hameka, HF Kay, JG TI Correlation of structure and vibrational spectra of the zwitterion L-alanine in the presence of water: an experimental and density functional analysis SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY LA English DT Article DE zwitterion; alpha-L-alanine; alpha-D-alanine; alpha-L-mannose; beta-L-mannose; vibrational circular dichroism; ab initio; density functional field theory; Moller-Plesset second-order perturbation theory; Becke 3 Lee Young Parr; Gaussian 98 ID CIRCULAR-DICHROISM; AMINO-ACIDS; REGION; PEPTIDES AB Infrared vibrational spectra were collected along with the vibrational circular dichroism (VCD) spectra for the zwitterions alpha-D-alanine, alpha-L-alanine, alpha-D-mannose and alpha-L-mannose as potassium bromide (KBr) pressed samples. VCD for D- and L-alanine dissolved in water was also measured and compared against the spectra resulting from KBr pressed samples. The experimental data were compared against the ab initio B3LYP/6-31G* optimized geometry. The zwitterion structure of alpha-L-alanine was stabilized by the addition of water molecules. Computationally, beta-L-mannose was studied and resulting expected VCD bands assigned. We present the molecular structures resulting VCD spectra and infrared vibrational spectra from experimentation as compared with the computed results. (C) 2003 Elsevier B.V. All rights reserved. C1 USA, Edgewood Res Dev & Engn Ctr, Aberdeen Proving Ground, MD 21010 USA. Univ Penn, Dept Chem, Philadelphia, PA 19104 USA. Drexel Univ, Dept Chem, Philadelphia, PA 19104 USA. RP Ellzy, MW (reprint author), USA, Edgewood Res Dev & Engn Ctr, Aberdeen Proving Ground, MD 21010 USA. NR 23 TC 32 Z9 32 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1386-1425 J9 SPECTROCHIM ACTA A JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. PD SEP PY 2003 VL 59 IS 11 BP 2619 EP 2633 DI 10.1016/S1386-1425(03)00036-2 PG 15 WC Spectroscopy SC Spectroscopy GA 728LV UT WOS:000185719400021 PM 12963459 ER PT J AU Wolter, SD Okuzumi, F Prater, JT Sitar, Z AF Wolter, SD Okuzumi, F Prater, JT Sitar, Z TI Bias frequency, waveform and duty-cycle effects on the bias-enhanced nucleation of epitaxial diamond SO THIN SOLID FILMS LA English DT Article DE chemical vapor deposition; diamond; epitaxy; plasma processing and deposition ID CHEMICAL-VAPOR-DEPOSITION; HIGHLY ORIENTED DIAMOND; SILICON; GROWTH AB In contrast to conventional DC bias-enhanced nucleation, a pre-carburization step was not needed in the processing of epitaxial diamond on (1 0 0) silicon using pulsed biasing. Otherwise, the procedure showed little frequency dependence on the epitaxial process in the range of 1 Hz-2 kHz, resulting in a constant percentage of highly oriented diamond of nearly 50%. The only variation with frequency was a linear increase in the bias current and a corresponding decrease in the biasing time required to form a quasi-continuous nucleation layer. In contrast, the variation of a 60-Hz square waveform duty cycle from 3 to 75% showed a decreasing hyperbolic relationship with the percentage of oriented diamond, with a plateau of similar to45% occurring at duty cycles of less than or equal to17%. The bias time to film formation was also determined to be inversely proportional to the duty cycle. The collective data highlights the relevance of the waveform attributes on the epitaxial nucleation of diamond on (1 0 0) silicon. (C) 2003 Elsevier Science B.V. All rights reserved. C1 N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Sitar, Z (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. NR 16 TC 2 Z9 2 U1 2 U2 3 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD SEP 1 PY 2003 VL 440 IS 1-2 BP 145 EP 151 DI 10.1016/S0040-6090(03)00827-7 PG 7 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 715BU UT WOS:000184951300022 ER PT J AU Lovelace, K VanGessel, Y Asher, LV Vogel, P AF Lovelace, K VanGessel, Y Asher, LV Vogel, P TI Spontaneous acute tumor lysis syndrome in a DBA/1J mouse: A case report and review SO TOXICOLOGIC PATHOLOGY LA English DT Review DE mouse; ATLS; acute tumor lysis syndrome; lymphoma; DNA emboli AB Spontaneous acute tumor lysis syndrome (ATLS) was diagnosed in a 10-month-old female DBA/1J sentinel mouse with leukemic lymphoma. The mouse was unable to maintain balance and died shortly after being observed rolling around in its cage. Disseminated neoplastic disease, including a large cranial mediastinal mass, enlarged lymph nodes and splenomegaly, was present at necropsy. Histopathologic examination revealed widespread massive necrosis of lymphoblastic tumor cells, and widely disseminated microemboli composed of nuclear and cytoplasmic cell debris. Although ATLS is widely recognized as an oncologic emergency in humans, acute lesions of ATLS have not been described. The mechanical obstruction of capillary beds by microemboli originating from disintegrating necrotic tumor cells was the likely cause of clinical signs and death in this mouse. We propose that similar microemboli may contribute to the pathogenesis of the acute renal failure and other clinical signs associated with ATLS in humans. Recognition of spontaneous ATLS in laboratory animals is especially important in studies that assess the efficacy and/or toxicity of anticancer treatments, where early deaths due to ATLS might mistakenly be attributed to a direct test article effect. C1 Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. RP Vogel, P (reprint author), Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. NR 9 TC 8 Z9 8 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0192-6233 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD SEP-OCT PY 2003 VL 31 IS 5 BP 486 EP 490 DI 10.1080/01926230390224674 PG 5 WC Pathology; Toxicology SC Pathology; Toxicology GA 712GG UT WOS:000184789300004 PM 14692616 ER PT J AU Rentas, FJ MacDonald, VW Houchens, DM Wallace, MW Mayer, W Reid, TJ AF Rentas, FJ MacDonald, VW Houchens, DM Wallace, MW Mayer, W Reid, TJ TI An "iceless" container capable of keeping red blood cells at 1-10 degrees C in austere environments for over 78 hours SO TRANSFUSION LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Association-of-Blood-Banks CY NOV 01-14, 2003 CL SAN DIEGO, CALIFORNIA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Thermo Solut, Minneapolis, MN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2003 VL 43 IS 9 SU S BP 56A EP 56A PG 1 WC Hematology SC Hematology GA 716TT UT WOS:000185045700189 ER PT J AU Rentas, FJ MacDonald, V Rothwell, S McFaul, S Asher, LV Kennedy, A Hmel, P Meledandri, C Salata, J Harman, R Reid, T AF Rentas, FJ MacDonald, V Rothwell, S McFaul, S Asher, LV Kennedy, A Hmel, P Meledandri, C Salata, J Harman, R Reid, T TI White particulate matter found in Terumo Blood Collection bags consisted of mostly platelets and white blood cells SO TRANSFUSION LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Association-of-Blood-Banks CY NOV 01-14, 2003 CL SAN DIEGO, CALIFORNIA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2003 VL 43 IS 9 SU S BP 62A EP 62A PG 1 WC Hematology SC Hematology GA 716TT UT WOS:000185045700210 ER PT J AU Rentas, FJ Colon, AF Lippert, LE Salata, J Harman, R Childs, J McFaul, S Reid, T Holmberg, J AF Rentas, FJ Colon, AF Lippert, LE Salata, J Harman, R Childs, J McFaul, S Reid, T Holmberg, J TI Post-thaw storage unaffected by the use of different plastic bags for freezing red blood cells SO TRANSFUSION LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Association-of-Blood-Banks CY NOV 01-14, 2003 CL SAN DIEGO, CALIFORNIA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Landstuhl Reg Med Ctr, Landstuhl, Germany. Haemonetics Corp, Braintree, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2003 VL 43 IS 9 SU S BP 68A EP 69A PG 2 WC Hematology SC Hematology GA 716TT UT WOS:000185045700232 ER PT J AU MacDonald, VW Hill, H Mongan, PD AF MacDonald, VW Hill, H Mongan, PD TI Inosine allows long-term storage of swine red blood cells for autologous transfusion in experimental trauma SO TRANSFUSION LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Association-of-Blood-Banks CY NOV 01-14, 2003 CL SAN DIEGO, CALIFORNIA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2003 VL 43 IS 9 SU S BP 69A EP 69A PG 1 WC Hematology SC Hematology GA 716TT UT WOS:000185045700235 ER PT J AU Rentas, FJ Lippert, L Harman, R Gomez, C Salata, J Childs, J Silva, T Richards, A Chan, C Jiang, J Dupuis, K Reid, T AF Rentas, FJ Lippert, L Harman, R Gomez, C Salata, J Childs, J Silva, T Richards, A Chan, C Jiang, J Dupuis, K Reid, T TI Inactivation of Orientia tsutsugamuchi in an animal model using the INTERCEPT Blood System for Platelets SO TRANSFUSION LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Association-of-Blood-Banks CY NOV 01-14, 2003 CL SAN DIEGO, CALIFORNIA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. USN, Med Res Inst, Silver Spring, MD USA. Cerus Corp, Concord, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2003 VL 43 IS 9 SU S BP 84A EP 84A PG 1 WC Hematology SC Hematology GA 716TT UT WOS:000185045700284 ER PT J AU Bermejo, CE Coursey, J Basler, J Austenfeld, M Thompson, I AF Bermejo, CE Coursey, J Basler, J Austenfeld, M Thompson, I TI Histologic confirmation of lesions identified by Prostascint (R) scan following definitive treatment SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS LA English DT Article ID RECURRENT PROSTATE-CANCER; (111)INDIUM-CAPROMAB PENDETIDE; RADICAL PROSTATECTOMY; LABELED CYT-356; DENDRITIC CELLS; VACCINE TRIAL; RADIOIMMUNOSCINTIGRAPHY; PEPTIDES; DISEASE AB The purpose of the study was to determine the accuracy of the monoclonal antibody (Mab) [Prostascint, Cytogen, Inc.] scan for the detection of nodal metastases using histologic examination of surgical lymphadenectomy specimens as the standard of reference. We reviewed the records of 31 patients who had undergone biopsy after monoclonal antibody scan. Histologic evaluation was obtained for a total of 31 patients and 43 pathology samples. When analyzed by surgical site, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the Mab scan were 94%, 42%, 53%, 92% and 65%, respectively. When analyzed by individual patient, the same data for the Mab scan were 100%, 33%, 62%, 100% and 68%, respectively. Current noninvasive studies are not sufficiently accurate to reliably determine the presence of metastatic nodal disease from prostate cancer. This series illustrates the importance of rigorous clinical evaluation of future methods that are designed to detect microscopic metastatic disease of any neoplasm. (C) 2003 Elsevier Inc. All rights reserved. C1 Univ Texas, Hlth Sci Ctr, Div Urol, San Antonio, TX USA. Brooke Army Med Ctr, Serv Urol, Ft Sam Houston, TX 78234 USA. RP Thompson, I (reprint author), Univ Texas, Hlth Sci Ctr, Div Urol, San Antonio, TX USA. NR 12 TC 9 Z9 10 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1078-1439 J9 UROL ONCOL-SEMIN O I JI Urol. Oncol.-Semin. Orig. Investig. PD SEP-OCT PY 2003 VL 21 IS 5 BP 349 EP 352 DI 10.1016/S1078-1439(02)00253-3 PG 4 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 755UT UT WOS:000187430400005 PM 14670541 ER PT J AU Rosen, LN Kaminski, RJ Parmley, AM Knudson, KH Fancher, P AF Rosen, LN Kaminski, RJ Parmley, AM Knudson, KH Fancher, P TI The effects of peer group climate on intimate partner violence among married male US army soldiers SO VIOLENCE AGAINST WOMEN LA English DT Article DE group climate; intimate partner violence; peer group; US Army soldiers ID PHYSICAL AGGRESSION; DOMESTIC VIOLENCE; COHESION; ADJUSTMENT; HUSBAND; SUPPORT; SCALES; UNITS; WOMEN; MEN AB This study examined the combined impact of individual-level and group-level variables on self-reported intimate partner violence, operationally defined as mild to severe physical aggression on the Modified Conflict Tactics Scale, among married male U.S. Army soldiers. The sample comprised 713 servicemen from 27 companies stationed at an Army post in the Alaskan interior. Group-level variables were based on individual reports on various dimensions of group climate aggregated at the company level. Contextual analyses were conducted using a variety of regression approaches. Individual-level predictor variables significantly associated with intimate partner violence included race, symptoms of depression, poor marital adjustment, alcohol problems, and a history of childhood abuse. Group-level predictor variables significantly associated with intimate partner violence included lower leadership support (vertical cohesion), a culture of hypermasculinity (operationally defined as increased group disrespect), and lower support for spouses. C1 Univ S Carolina, Columbia, SC 29208 USA. USA, Washington, DC 20310 USA. NR 56 TC 29 Z9 29 U1 1 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1077-8012 J9 VIOLENCE AGAINST WOM JI Violence Against Women PD SEP PY 2003 VL 9 IS 9 BP 1045 EP 1071 DI 10.1177/1077801203255504 PG 27 WC Women's Studies SC Women's Studies GA 710DW UT WOS:000184666400002 ER PT J AU Woodard, CL Li, ZY Kathcart, AK Terrell, J Gerena, L Lopez-Sanchez, M Kyle, DE Bhattacharjee, AK Nichols, DA Ellis, W Prigge, ST Geyer, JA Waters, NC AF Woodard, CL Li, ZY Kathcart, AK Terrell, J Gerena, L Lopez-Sanchez, M Kyle, DE Bhattacharjee, AK Nichols, DA Ellis, W Prigge, ST Geyer, JA Waters, NC TI Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID CELL-CYCLE; CHEMICAL INHIBITORS; CDC2-RELATED KINASE; PURINE DERIVATIVES; AUTOMATED DOCKING; CDK4 INHIBITORS; LIBRARY DESIGN; ACTIVATION; PFMRK; EXPRESSION AB Cyclin dependent protein kinases (CDKs) have become attractive drug targets in an effort to identify effective inhibitors of the parasite Plasmodium falciparum, the causative agent of the most severe form of human malaria. We tested known CDK inhibitors for their ability to inhibit two malarial CDKs: Pfmrk and PfPK5. Many broad spectrum CDK inhibitors failed to inhibit Pfmrk suggesting that the active site differs from other CDKs in important ways. By screening compounds in the Walter Reed chemical database, we identified oxindole-based compounds as effective inhibitors of Pfmrk (IC50 = 1.5 muM). These compounds have low cross-reactivity against PfPK5 and human CDK1 demonstrating selectivity for Pfmrk. Amino acid comparison of the active sites of Pfmrk and PfPK5 identified unique amino acid differences that may explain this selectivity and be exploited for further drug development efforts. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Malaria Res Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. USA, Med Res Unit Kenya 64109, APO, AE 09831 USA. RP Waters, NC (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. NR 41 TC 81 Z9 83 U1 2 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD AUG 28 PY 2003 VL 46 IS 18 BP 3877 EP 3882 DI 10.1021/jm0300983 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 714YL UT WOS:000184942500013 PM 12930149 ER PT J AU Moore, JT Corn, JD Chu, D Jiang, RZ Boxall, DL Kenik, EA Lukehart, CM AF Moore, JT Corn, JD Chu, D Jiang, RZ Boxall, DL Kenik, EA Lukehart, CM TI Synthesis and characterization of a Pt3Ru1/Vulcan carbon powder nanocomposite and reactivity as a methanol electrooxidation catalyst SO CHEMISTRY OF MATERIALS LA English DT Article ID HIGH RELATIVE PERFORMANCE; PT-RU ANODES; FUEL-CELLS; NANOPARTICLES; OXIDATION; ALLOY; ELECTROCATALYSIS; COMPLEXES; TERNARY; GROWTH AB Thermal treatment of [Ru(2,3-bis(2-pyridyl)quinoxaline)(3)(PtCl2)(3)](BF4)(2)/Vulcan carbon powder composites under reactive conditions forms Pt-Ru/carbon nanocomposites containing 27-34 wt % metal alloy as highly dispersed nanoparticles of ca. Pt75Ru25 stoichiometry. The metal nanoparticles have an average diameter of 6 nm (by TEM) and an fcc unit cell of lattice constant 3.907 (9) Angstrom, as expected for Pt-rich Pt-Ru alloys. On-particle HR-EDS analysis indicates that gross phase separation of Pt and Ru does not occur on the nanoparticle scale. Evaluation of the performance of this nanocomposite as a methanol electrooxidation catalyst in a direct methanol fuel cell and in an electrochemical cell designed for combinatorial testing is reported. C1 Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA. USA, Res Lab, Sensors & Electron Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA. Oak Ridge Natl Lab, Div Met & Ceram, Oak Ridge, TN 37831 USA. RP Lukehart, CM (reprint author), Vanderbilt Univ, Dept Chem, 221 Kirkland Hall, Nashville, TN 37235 USA. NR 39 TC 44 Z9 45 U1 3 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD AUG 26 PY 2003 VL 15 IS 17 BP 3320 EP 3325 DI 10.1021/cm030145f PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 713CP UT WOS:000184838300016 ER PT J AU Soon, BY Haus, JW Scalora, M Sibilia, C AF Soon, BY Haus, JW Scalora, M Sibilia, C TI One-dimensional photonic crystal optical limiter SO OPTICS EXPRESS LA English DT Article ID REVERSE SATURABLE ABSORPTION; EXCITED-STATE ABSORPTION; NONLINEAR ABSORPTION; PROPAGATION; PICOSECOND; PULSES; PHTHALOCYANINES; MEDIA; DYES AB We explore a new passive optical limiter design using transverse modulation instability in the one-dimensional photonic crystal (PC) using chi((3)) materials. The performance of PC optical limiters strongly depends on the choice of the materials and the geometry and it improves as the duration of the incident pulse is extended. PC optical limiter performance is compared with that of a device made from homogeneous material. We identify three criteria for benchmarking the PC optical limiter. We also include a discussion of the advantages and disadvantages of PC optical limiters for real world applications. (C) 2003 Optical Society of America. C1 Univ Dayton, Electroopt Program, Dayton, OH 45419 USA. USA, Missile Command, Weap Sci Directorate, AMSMI RD WS ST,RD & EC, Redstone Arsenal, AL 35898 USA. Univ Roma La Sapienza, INFM, I-00161 Rome, Italy. Univ Roma La Sapienza, Dipartimento Energet, I-00161 Rome, Italy. RP Soon, BY (reprint author), Univ Dayton, Electroopt Program, Dayton, OH 45419 USA. EM boonyi@yahoo.com; jwhaus@udayton.edu NR 33 TC 38 Z9 44 U1 2 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD AUG 25 PY 2003 VL 11 IS 17 BP 2007 EP 2018 DI 10.1364/OE.11.002007 PG 12 WC Optics SC Optics GA 715BT UT WOS:000184951200009 PM 19466087 ER PT J AU Furbert-Harris, P Parish-Gause, D Laniyan, I Hunter, KA Okomo-Awich, J Vaughn, TR Forrest, KC Howland, C Abdelnaby, A Oredipe, OA AF Furbert-Harris, P Parish-Gause, D Laniyan, I Hunter, KA Okomo-Awich, J Vaughn, TR Forrest, KC Howland, C Abdelnaby, A Oredipe, OA TI Inhibition of prostate cancer cell growth by activated eosinophils SO PROSTATE LA English DT Article DE eosinophils; prostate cancer; cytokine; DU 145; PC-3; cytotoxic T lymphocytes (CTLs) ID VIRUS THYMIDINE-KINASE; DENDRITIC CELLS; GRANZYME-B; PROGNOSTIC-SIGNIFICANCE; TISSUE EOSINOPHILIA; BLOOD EOSINOPHILS; HODGKINS-DISEASE; CTL RESPONSES; TUMOR; CARCINOMA AB BACKGROUND. Host Immune response to prostate cancer primarily involves the CTL and NK effector cells. Recent immunotherapeutic strategies incorporating cytokine genes into the tumor cell and/or dendritic cells have had encouraging results. In this study, we describe the inhibitory activity of a third potential effector cell, the eosinophil, against DU 145 and PC-3 prostate tumor cells growth in vitro. METHODS. Subconfluent monolayer cultures of DU 145 and PC-3 cells were incubated with peripheral blood eosinophils from allergic or asthmatic individuals and also with eosinophil cultured supernatants. Newly established eosinophil cell lines were also studied. After harvesting, the plates were washed and stained with Hematoxylin/eosin (H/E) then photographed. The combination of monolayer cell growth inhibition and colony formation inhibition assays were used to evaluate eosinophil inhibitory activity. In the colony formation inhibition assay one hundred cells per well in 6-well plates were incubated overnight, after which peripheral blood eosinophils, conditioned media and cytokines, IL-4 and TNF-alpha were added. The plates were harvested after 10 days incubation period. Colonies were stained and counted. RESULTS. Hypo- and hyperdense peripheral blood eosinophils from allergic and asthmatic individuals as well as eosinophil cell lines established from these subpopulations inhibited both DU 145 and PC-3 cell growth at 58-78% and 10-38%, respectively. IL-5 up-regulated eosinophil cell line activity by 21-24%. The conditioned media which contained the released mediators of activated eosinophils were potent in their actions on both DU 145 and PC-3, inhibiting colony formation by as much as 90-100%. CONCLUSION. These results clearly demonstrate the inhibitory potential of activated eosinophils and their released "soup" of mediators and therefore support the hypothesis that eosinophils may participate in host response to prostate cancer together with CTLs and NK cells. Furthermore, this study offers insights into possible strategies for enhancing eosinophilic activity in prostate cancer. (C) 2003 Wiley-Liss, Inc. C1 Howard Univ, Ctr Canc, Coll Med, Dept Microbiol, Washington, DC 20060 USA. Howard Univ, Coll Med, Dept Pharmacol, Washington, DC 20060 USA. Howard Univ, Coll Med, Dept Surg, Washington, DC 20060 USA. Howard Univ, Coll Med, Dept Canc, Washington, DC 20060 USA. Howard Univ, Coll Med, Ctr Human Genome, Washington, DC 20060 USA. Walter Reed Army Med Ctr, Dept Anesthesiol, Washington, DC 20060 USA. RP Furbert-Harris, P (reprint author), Howard Univ, Ctr Canc, Coll Med, Dept Microbiol, 2041 Georgia Ave,NW,530, Washington, DC 20060 USA. NR 55 TC 12 Z9 12 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0270-4137 J9 PROSTATE JI Prostate PD AUG 22 PY 2003 VL 57 IS 2 BP 165 EP 175 DI 10.1002/pros.10286 PG 11 WC Endocrinology & Metabolism; Urology & Nephrology SC Endocrinology & Metabolism; Urology & Nephrology GA 725XX UT WOS:000185568600010 PM 12949941 ER PT J AU Lesho, EP Gey, DC AF Lesho, EP Gey, DC TI Managing issues related to antiretroviral therapy SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTED PATIENTS; ST-JOHNS WORT; RISK-FACTORS; HEPATITIS-C; NEVIRAPINE; DRUG; ADULTS; HYPERLACTATEMIA; OSTEONECROSIS AB Antiretroviral regimens are complicated and difficult for patients to follow, and they can have serious side effects, such as osteonecrosis and bone demineralization. Protease inhibitor therapy has been associated with hyperlipidemia, hyperglycemia, gastrointestinal symptoms, and body-fat distribution abnormalities. Nonnucleoside reverse transcriptase inhibitors can cause rashes and hepatotoxicity, and nucleoside reverse transcriptase inhibitors can cause lactic acidosis, hypersensitivity reactions, neuropathies, pancreatitis, anemia, and neutropenia. Malabsorption can occur if antiretroviral agents are taken improperly with regard to meals or if they are taken with certain other drugs or herbal remedies. Some commonly prescribed drugs can cause dangerous drug toxicities if they are taken by patients who are also taking certain antiretroviral medications. Suboptimal exposure to antiretrovirals because of noncompliance or malabsorption can result in Viral resistance and loss of future treatment options. Copyright(C) 2003 American Academy of Family Physicians. C1 USA, Med Dept Act, Heidelberg, Germany. Univ Heidelberg, Sch Med, Heidelberg, Germany. RP Lesho, EP (reprint author), USA, MC, LTC, 611 Forest Glen Rd, Silver Spring, MD 20901 USA. NR 42 TC 18 Z9 19 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD AUG 15 PY 2003 VL 68 IS 4 BP 675 EP 686 PG 12 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 714JR UT WOS:000184910700008 PM 12952384 ER PT J AU Singh, SN Singh, BN Reda, DJ Fye, CL Ezekowitz, MD Fletcher, RD Sharma, SC Atwood, JE Jacobson, AK Lewis, HD Antman, EM Falk, RH Lopez, B Tang, XC AF Singh, SN Singh, BN Reda, DJ Fye, CL Ezekowitz, MD Fletcher, RD Sharma, SC Atwood, JE Jacobson, AK Lewis, HD Antman, EM Falk, RH Lopez, B Tang, XC TI Comparison of Sotalol versus Amiodarone in maintaining stability of sinus rhythm in patients with atrial Fibrillation (Sotalol-Amiodarone fibrillation Efficacy Trial [SAFE-T]) SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Article ID ANTIARRHYTHMIC DRUGS; MECHANISMS AB The Sotalol-Amiodarone Fibrillation Efficacy Trial (SAFE-T) is a randomized, double-blind, multicenter, placebo-controlled trial in which the effects of sotalol and amiodarone in maintaining stability of sinus rhythm are being examined in patients with persistent atrial fibrillation at 20 Veterans Affairs medical centers. The time to the occurrence of atrial fibrillation or flutter in patients with atrial fibrillation converted to sinus rhythm is the primary outcome measure, with a number of parameters as secondary end points. SAFE-T had randomized 665 patients when enrollment terminated on October 31, 2001. Follow-up of patients continued until October 31, 2002, for a maximum period of 54 months and a minimum period of 12 months for all patients. (C)2003 by Excerpta Medica, Inc. C1 Vet Adm Med Ctr, Div Cardiol, Washington, DC 20422 USA. Vet Affairs Hosp, Los Angeles, CA USA. Vet Affairs Med Ctr, Hines, IL USA. Vet Affairs Med Ctr, Providence, RI USA. Vet Affairs Med Ctr, Loma Linda, CA USA. Vet Affairs Med Ctr, Kansas City, MO USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Med Coll Penn & Hahnemann Univ, Philadelphia, PA USA. Brigham & Womens Hosp, Boston, MA 02115 USA. Boston Univ, Boston, MA 02215 USA. RP Singh, SN (reprint author), Vet Adm Med Ctr, Div Cardiol, 50 Irving St NW, Washington, DC 20422 USA. NR 9 TC 24 Z9 26 U1 0 U2 1 PU EXCERPTA MEDICA INC PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD AUG 15 PY 2003 VL 92 IS 4 BP 468 EP 472 DI 10.1016/S0002-9149(03)00671-4 PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 709WU UT WOS:000184650200023 PM 12914883 ER PT J AU Ko, BK Kawano, K Murray, JL Disis, ML Efferson, CL Kuerer, HM Peoples, GE Ioannides, CG AF Ko, BK Kawano, K Murray, JL Disis, ML Efferson, CL Kuerer, HM Peoples, GE Ioannides, CG TI Clinical studies of vaccines targeting breast cancer SO CLINICAL CANCER RESEARCH LA English DT Review ID CYTOTOXIC T-LYMPHOCYTES; TUMOR-ASSOCIATED ANTIGENS; HUMAN CARCINOEMBRYONIC ANTIGEN; ACTIVE SPECIFIC IMMUNOTHERAPY; COLONY-STIMULATING FACTOR; CELLULAR IMMUNE-RESPONSE; SYNTHETIC MUC1 PEPTIDE; PHASE-I TRIAL; METASTATIC BREAST; OVARIAN-CANCER AB Many clinical studies have been undertaken to assess the therapeutic potential of vaccination and have included a large variety of cancer immunogens. Most of these studies involved patients with metastatic cancer, which is characterized by the most aggressive malignant cells, the longest lasting disease, and the failure of all standard cytotoxic treatments. The presence of tumor over long periods and the toxicity of previous treatments tend to negatively affect immune responsiveness to tumor antigens presented by the vaccine. In this review, we analyze the ability of past and current vaccine therapies to induce clinical responses in breast cancer. To date, clinical responses have been observed by using vaccines targeting HER-2/neu protein, human telomerase reverse transcriptase, carcinoembryonic antigen, and carbohydrate antigen given after stem cell rescue. The review concludes with a discussion of possible future directions for vaccine development and applications. C1 Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA. Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. Univ Texas, MD Anderson Canc Ctr, Dept Bioimmunotherapy, Houston, TX 77030 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Univ Washington, Dept Oncol, Seattle, WA 98195 USA. RP Ioannides, CG (reprint author), Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, 1515 Holcombe Blvd,Box 440, Houston, TX 77030 USA. FU NCI NIH HHS [K24CA85218, R01CA85374] NR 108 TC 37 Z9 37 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI BIRMINGHAM PA PO BOX 11806, BIRMINGHAM, AL 35202 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD AUG 15 PY 2003 VL 9 IS 9 BP 3222 EP 3234 PG 13 WC Oncology SC Oncology GA 718XW UT WOS:000185172600002 PM 12960107 ER PT J AU Berenzon, D Schwenk, RJ Letellier, L Guebre-Xabier, M Williams, J Krzych, U AF Berenzon, D Schwenk, RJ Letellier, L Guebre-Xabier, M Williams, J Krzych, U TI Protracted protection to Plasmodium berghei malaria is linked to functionally and phenotypically heterogeneous liver memory CD8(+) T cells SO JOURNAL OF IMMUNOLOGY LA English DT Article ID IN-VIVO; IRRADIATED SPOROZOITES; FALCIPARUM SPOROZOITES; IMMUNITY; EFFECTOR; PROLIFERATION; LYMPHOCYTES; ANTIGEN; VIRUS; MICE AB We previously demonstrated that protection induced by radiation-attenuated (gamma) Plasmodium berghei sporozoites is linked to MHC class I-restricted CD8(+) T cells specific for exoerythrocytic-stage Ags, and that activated intrahepatic memory CD8(+) T cells are associated with protracted protection. In this study, we further investigated intrahepatic memory CD8+ T cells to elucidate mechanisms required for their maintenance. Using phenotypic markers indicative of activation (CD44, CD45RB), migration (CD62L), and IFN-gamma production, we identified two subsets of intrahepatic memory CD8(+) T cells: the CD44(high) CD45RB(low)CD62L(low)CDI22(low) phenotype, representing the dominant effector memory set, and the CD44(high)CD45RB(high)CD62L(low/high)CD122(high) phenotype, representing the central memory set. Only the effector memory CD8(+) T cells responded swiftly to sporozoite challenge by producing sustained IFN-gamma; the central memory T cells responded with delay, and the IFN-gamma reactivity was short-lived. In addition, the subsets of liver memory CD8(+) T cells segregated according to the expression of CD122 (IL-15R) in that only the central memory CD8(+) T cells were CD122 high, whereas the effector memory CD8(+) T cells were CD122(low). Moreover, the effector memory CD8(+) T cells declined as protection waned in mice treated with primaquine, a drug that interferes with the formation of liver-stage Ags. We propose that protracted protection induced by P. berghei radiation-attenuated sporozoites depends in part on a network of interactive liver memory CD8(+) T cell subsets, each representing a different phase of activation or differentiation, and the balance of which is profoundly affected by the repository of liver-stage Ag and EL-15. C1 Walter Reed Army Inst Res, Dept Immunol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. RP Krzych, U (reprint author), Walter Reed Army Inst Res, Dept Immunol, Div Communicable Dis & Immunol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU NIAID NIH HHS [AI 46438] NR 44 TC 75 Z9 77 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD AUG 15 PY 2003 VL 171 IS 4 BP 2024 EP 2034 PG 11 WC Immunology SC Immunology GA 710EG UT WOS:000184667400053 PM 12902507 ER PT J AU Alley, RB Lawson, DE Larson, GJ Evenson, EB Baker, GS AF Alley, RB Lawson, DE Larson, GJ Evenson, EB Baker, GS TI Stabilizing feedbacks in glacier-bed erosion SO NATURE LA English DT Article ID FREEZE-ON MECHANISM; RICH BASAL ICE; TIDEWATER GLACIERS; SEDIMENT; ALASKA AB Glaciers often erode, transport and deposit sediment much more rapidly than nonglacial environments(1), with implications for the evolution of glaciated mountain belts and their associated sedimentary basins. But modelling such glacial processes is difficult, partly because stabilizing feedbacks similar to those operating in rivers(2,3) have not been identified for glacial landscapes. Here we combine new and existing data of glacier morphology and the processes governing glacier evolution from diverse settings to reveal such stabilizing feedbacks. We find that the long profiles of beds of highly erosive glaciers tend towards steady-state angles opposed to and slightly more than 50 per cent steeper than the overlying ice-air surface slopes, and that additional subglacial deepening must be enabled by non-glacial processes. Climatic or glaciological perturbations of the ice-air surface slope can have large transient effects on glaciofluvial sediment flux and apparent glacial erosion rate. C1 Penn State Univ, Dept Geosci, University Pk, PA 16802 USA. Penn State Univ, EMS Environm Inst, University Pk, PA 16802 USA. Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. Lehigh Univ, Dept Earth & Environm Sci, Bethlehem, PA 18015 USA. SUNY Buffalo, Dept Geol, Buffalo, NY 14260 USA. RP Alley, RB (reprint author), Penn State Univ, Dept Geosci, University Pk, PA 16802 USA. NR 30 TC 104 Z9 105 U1 2 U2 29 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 J9 NATURE JI Nature PD AUG 14 PY 2003 VL 424 IS 6950 BP 758 EP 760 DI 10.1038/nature01839 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 711HQ UT WOS:000184733900034 PM 12917679 ER PT J AU Tsuboi, T Kaneko, O Eitoku, C Suwanabun, N Sattabongkot, J Vinetz, JM Torii, M AF Tsuboi, T Kaneko, O Eitoku, C Suwanabun, N Sattabongkot, J Vinetz, JM Torii, M TI Gene structure and ookinete expression of the chitinase genes of Plasmodium vivax and Plasmodium yoelii SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE malaria; Plasmodium vivax; Plasmodium yoelii; ookinete; chitinase ID MALARIA PARASITE CHITINASE; MOSQUITO MIDGUT; IN-VITRO; SEQUENCE; INVASION C1 Ehime Univ, Sch Med, Dept Mol Parasitol, Shigenobu, Ehime 7910295, Japan. Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Univ Calif San Diego, Sch Med, Dept Med, Div Infect Dis, La Jolla, CA 92037 USA. RP Tsuboi, T (reprint author), Ehime Univ, Sch Med, Dept Mol Parasitol, Shigenobu, Ehime 7910295, Japan. OI Vinetz, Joseph/0000-0001-8344-2004 FU NIAID NIH HHS [5K02AI50499, 5R01AI45999] NR 18 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD AUG 11 PY 2003 VL 130 IS 1 BP 51 EP 54 DI 10.1016/S0166-6851(03)00140-3 PG 4 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA 719VC UT WOS:000185224900006 PM 14550896 ER PT J AU Sullivan, NJ Geisbert, TW Geisbert, JB Xu, L Yang, ZY Roederer, M Koup, RA Jahrling, PB Nabel, GJ AF Sullivan, NJ Geisbert, TW Geisbert, JB Xu, L Yang, ZY Roederer, M Koup, RA Jahrling, PB Nabel, GJ TI Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates SO NATURE LA English DT Article ID PASSIVE TRANSFER; INFECTION; GLYCOPROTEINS; CYTOTOXICITY; INJURY; GENE AB Containment of highly lethal Ebola virus outbreaks poses a serious public health challenge. Although an experimental vaccine has successfully protected non-human primates against disease(1), more than six months was required to complete the immunizations, making it impractical to limit an acute epidemic. Here, we report the development of accelerated vaccination against Ebola virus in non-human primates. The antibody response to immunization with an adenoviral (ADV) vector encoding the Ebola glycoprotein (GP) was induced more rapidly than with DNA priming and ADV boosting, but it was of lower magnitude. To determine whether this earlier immune response could nonetheless protect against disease, cynomolgus macaques were challenged with Ebola virus after vaccination with ADV-GP and nucleoprotein (NP) vectors. Protection was highly effective and correlated with the generation of Ebola-specific CD8(+) T-cell and antibody responses. Even when animals were immunized once with ADV-GP/NP and challenged 28 days later, they remained resistant to challenge with either low or high doses of virus. This accelerated vaccine provides an intervention that may help to limit the epidemic spread of Ebola, and is applicable to other viruses. C1 NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Nabel, GJ (reprint author), NIAID, Vaccine Res Ctr, NIH, Bldg 40,Room 4502,MSC 3005,40 Convent Dr, Bethesda, MD 20892 USA. RI Roederer, Mario/G-1887-2011 NR 17 TC 301 Z9 315 U1 3 U2 78 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 J9 NATURE JI Nature PD AUG 7 PY 2003 VL 424 IS 6949 BP 681 EP 684 DI 10.1038/nature01876 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 708QE UT WOS:000184578800047 PM 12904795 ER PT J AU Wisenbaugh, T AF Wisenbaugh, T TI Editorial comment - Unexpected, dismal left ventricular function after surgery for mitral regurgitation - There is just no excuse for it anymore SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Editorial Material C1 Tripler Army Med Ctr, Dept Med, Cardiol Sect, Honolulu, HI 96859 USA. RP Wisenbaugh, T (reprint author), Tripler Army Med Ctr, Dept Med, Cardiol Sect, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 6 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD AUG 6 PY 2003 VL 42 IS 3 BP 464 EP 465 DI 10.1016/S0735-1097(03)00651-X PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 707UF UT WOS:000184527700011 PM 12906973 ER PT J AU Cohen, SP Mao, J AF Cohen, SP Mao, J TI Is the analgesic effect of systemic lidocaine mediated through opioid receptors? SO ACTA ANAESTHESIOLOGICA SCANDINAVICA LA English DT Letter ID RAT C1 Walter Reed Army Med Ctr, Pain Management Ctr, Dept Anesthesiol, Washington, DC 20307 USA. Harvard Univ, Sch Med, Massachusetts Gen Hosp, MGH Pain Ctr,Dept Anesthesia & Crit Care, Boston, MA USA. RP Cohen, SP (reprint author), 268 E Broadway,Apt A 1407, New York, NY 10002 USA. NR 8 TC 8 Z9 9 U1 0 U2 0 PU BLACKWELL MUNKSGAARD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0001-5172 J9 ACTA ANAESTH SCAND JI Acta Anaesthesiol. Scand. PD AUG PY 2003 VL 47 IS 7 BP 910 EP 911 DI 10.1034/j.1399-6576.2003.00163.x PG 2 WC Anesthesiology SC Anesthesiology GA 700KT UT WOS:000184111700022 PM 12859317 ER PT J AU Pan, YL Hartings, J Pinnick, RG Hill, SC Halverson, J Chang, RK AF Pan, YL Hartings, J Pinnick, RG Hill, SC Halverson, J Chang, RK TI Single-particle fluorescence spectrometer for ambient aerosols SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID AIRBORNE BIOLOGICAL PARTICLES; LIGHT-SCATTERING; RESPONSE CHARACTERISTICS; INTRINSIC FLUORESCENCE; ATMOSPHERIC AEROSOL; OPTICAL-ABSORPTION; SPECTRUM ANALYZER; UV FLUORESCENCE; LASER; SPECTROSCOPY AB A fluorescence particle spectrometer (FPS) for real-time measurement of the fluorescence spectra of aerosol particles in the size range 1-10 mum diameter is reported. The prototype FPS has a sufficiently high sample rate (from 5 to 28 l/min for 3.5 mum to 11 mum diameter particles) to measure aerosol within buildings at practical rates (from 1 up to 600 particle fluorescence spectra per minute). Previously reported bioaerosol prototype detectors for measurement of single particle spectra (Pan et al., Opt. Lett., 24, 116-118 (1999); Hill et al., Field Anal. Chem. Tech., 3, 221-239 (1999)) were unable to sample the ambient environment; air containing particles had to be forced under pressure into a sample cell. In addition, sample rates were so small (less than 0.01 l/min) as to be impractical for most applications. The present design overcomes these deficiencies by the use of an airtight cell that highly concentrates micrometer-sized particles. A virtual impactor first concentrates aerosol particles, which are then drawn under negative pressure through an aerodynamic focusing nozzle in the inlet of the instrument, through the sample region, providing further concentration. The rate of particle spectra measured by the FPS increases significantly when the particle inlet is within a few meters of some common sources of indoor biological particles, e. g., a person coughing, sneezing, or rubbing his skin, or the presence of a dog. The spectra obtained have a variety of spectral shapes. The FPS may be useful in a variety of areas, e. g., in studying and monitoring airborne particles that cause diseases or allergies. C1 Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. Yale Univ, Ctr Laser Diagnost, New Haven, CT 06520 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. USA, Res Lab, Adelphi, MD USA. Westinghouse Savannah River Co, Aiken, SC USA. RP Pan, YL (reprint author), Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. EM yongle.pan@yale.edu NR 47 TC 68 Z9 69 U1 3 U2 24 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 520 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD AUG PY 2003 VL 37 IS 8 BP 628 EP 639 DI 10.1080/02786820300904 PG 12 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 673DM UT WOS:000182565000003 ER PT J AU Kupres, K Meffert, JJ AF Kupres, K Meffert, JJ TI Ashy dermatosis SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material C1 Brooke Army Med Ctr, San Antonio, TX 78259 USA. RP Kupres, K (reprint author), Brooke Army Med Ctr, San Antonio, TX 78259 USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD AUG 1 PY 2003 VL 68 IS 3 BP 529 EP 530 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 711KY UT WOS:000184740800009 PM 12924837 ER PT J AU Sarantopoulos, GP Binder, S Wortmann, G Hochberg, L Healey, P AF Sarantopoulos, GP Binder, S Wortmann, G Hochberg, L Healey, P TI Old world cutaneous leishmaniasis in Los Angeles: A case report, overview of the current literature, and guide for the treating dermatopathologist SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article DE cutaneous leishmaniasis; old world; Leishman-Donovan bodies; PCR ID POLYMERASE-CHAIN-REACTION; KINETOPLAST DNA; DIAGNOSIS; PCR; IDENTIFICATION; AMPLIFICATION; HYBRIDIZATION; PARASITES; INFANTUM; REPEATS AB We describe a case of cutaneous leishmaniasis in a Spanish patient visiting Los Angeles. Leishmania species cause both cutaneous and visceral disease; the majority of infections with Leishmania are of the cutaneous form. Although leishmaniasis is a relatively rare occurrence in the United States, travel by United States' citizens to endemic regions and increased United States military operations in the Middle East raise the chances of encountering cutaneous leishmaniasis. The following case report and overview of the current literature outlines the major morphologic findings and current diagnostic modalities available to diagnose cutaneous leishmaniasis. C1 Univ Calif Los Angeles, Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Dermatol Associates Med Grp, Beverly Hills, CA USA. RP Sarantopoulos, GP (reprint author), Univ Calif Los Angeles, Med Ctr, Dept Pathol & Lab Med, Rm 13-145,CHS 10833 Le Conte Ave, Los Angeles, CA 90095 USA. NR 40 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD AUG PY 2003 VL 25 IS 4 BP 321 EP 326 DI 10.1097/00000372-200308000-00006 PG 6 WC Dermatology SC Dermatology GA 703RX UT WOS:000184295700006 PM 12876489 ER PT J AU McLaughlin, CT Kane, AG Auber, AE AF McLaughlin, CT Kane, AG Auber, AE TI MR imaging of heat stroke: external capsule and thalamic T1 shortening and cerebellar injury SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article ID WHITE-MATTER; PATIENT; LESIONS AB We present a case of increased signal intensity of the cerebrum (symmetric involvement of the paraventricular thalamus and external capsule) and cerebellum on both T1- and T2-weighted images in a patient with documented heat stroke. An ischemic and hemorrhagic mechanism is proposed, and the contributions of the direct effects of hyperthermia are discussed. C1 Tripler Army Med Ctr, Dept Radiol, Neuroradiol Sect, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Hlth Educ & Training, Honolulu, HI 96859 USA. Ohio State Univ, Coll Med & Publ Hlth, Columbus, OH 43210 USA. Brooke Army Med Ctr, Dept Radiol, Neuroradiol Sect, San Antonio, TX USA. RP Kane, AG (reprint author), Tripler Army Med Ctr, Dept Radiol, Neuroradiol Sect, Jarrett White Rd, Honolulu, HI 96859 USA. NR 19 TC 23 Z9 27 U1 1 U2 1 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 USA SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD AUG PY 2003 VL 24 IS 7 BP 1372 EP 1375 PG 4 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 713MB UT WOS:000184860800021 PM 12917130 ER PT J AU Oh, KT Longmuir, R Oh, DM Stone, EM Kopp, K Brown, J Fishman, GA Sonkin, P Gehrs, KM Weleber, RG AF Oh, KT Longmuir, R Oh, DM Stone, EM Kopp, K Brown, J Fishman, GA Sonkin, P Gehrs, KM Weleber, RG TI Comparison of the clinical expression of retinitis pigmentosa associated with rhodopsin mutations at codon 347 and codon 23 SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID RIBOZYME GENE-THERAPY; HETEROGENEITY; FAMILIES; DISEASE; RATES; CONE; ROD; DNA AB PURPOSE: To examine the difference in expression of retinitis pigmentosa from mutations at codon 23 and codon 347 or rhodopsin; to report a novel mutation in rhodopsin. METHODS: Goldmann perimetry (solid angle of I4e isopter) and electroretinographic amplitudes (square root transform of a response ratio) were analyzed for 24 patients with mutations at codon 347 (15 with Pro347Ala, 2 with Pro347Gln, 6 with Pro347Leu, and I with a novel Pro347Cys change) and 41 patients with mutations at codon 23 (6 with Pro23Ala; 35 with Pro23His). RESULTS: When all patients with mutations at codons 347 and 23 were compared, loss of visual fields was significantly worse in patients with codon 347 changes (P =.0003). Only rod responses of the electroretinograms were significantly different between the two groups (P =.048). Specific comparison of Pro347Ala with Pro23Ala using regression analysis demonstrated significant differences in severity between codon 23 and codon 347 patients for b-wave amplitudes of rod (P =.0069), cone (P =.039) and maximum combined response (P =.049). The solid angle of the I4e isopter was also significantly different (P =.025) between the groups after controlling for age. Modeling age by group for Pro347Ala comparison produced an R-2 of .44. CONCLUSION: We reconfirmed that rhodopsin,related retinitis pigmentosa from mutations involving codon 347 produces a more severe phenotype than that involving codon 23. Accurate modeling of disease was shown to be possible by incorporating the effects of a patient's age and specific genotype. Therefore, both of these variables must be considered in prognostic counseling and subject recruitment for future therapeutic trials. C1 Casey Eye Inst, Portland, OR 97201 USA. Univ N Carolina, Dept Ophthalmol, Chapel Hill, NC USA. Univ Iowa Hosp & Clin, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Univ Illinois, Illinois Eye & Ear Infirm, Chicago, IL USA. Retina Vitreous Associates, Nashville, TN USA. Oregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR USA. Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR USA. RP Weleber, RG (reprint author), Casey Eye Inst, 3375 SW Terwilliger, Portland, OR 97201 USA. NR 38 TC 23 Z9 28 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD AUG PY 2003 VL 136 IS 2 BP 306 EP 313 DI 10.1016/S0002-9394(03)00206-X PG 8 WC Ophthalmology SC Ophthalmology GA 702YT UT WOS:000184253200013 PM 12888054 ER PT J AU Pavlin, JA Mostashari, F Kortepeter, MG Hynes, NA Chotani, RA Mikol, YB Ryan, MAK Neville, JS Gantz, DT Writer, JV Florance, JE Culpepper, RC Henretig, FM Kelley, PW AF Pavlin, JA Mostashari, F Kortepeter, MG Hynes, NA Chotani, RA Mikol, YB Ryan, MAK Neville, JS Gantz, DT Writer, JV Florance, JE Culpepper, RC Henretig, FM Kelley, PW TI Innovative surveillance methods for rapid detection of disease outbreaks and bioterrorism: Results of an interagency workshop on health indicator surveillance SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID ILLNESS; RECORDS; CITY C1 Dept Def Global Emerging Infect Syst, Silver Spring, MD USA. New York City Dept Hlth, New York, NY 10013 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Publ Hlth Serv, Washington, DC USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. New York City Dept Environm Protect, New York, NY USA. USN, Hlth Res Ctr, San Diego, CA 92152 USA. USAF, Inst Environm Safety & Occupat Hlth Risk, Brooks AFB, TX USA. George Mason Univ, Dept Appl & Engn Stat, Fairfax, VA 22030 USA. Prince William Cty Hlth Dist, Manassas, VA USA. Childrens Hosp Philadelphia, Clin Toxicol & Poison Control Dept, Philadelphia, PA 19104 USA. RP Pavlin, JA (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 22 TC 24 Z9 25 U1 1 U2 2 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD AUG PY 2003 VL 93 IS 8 BP 1230 EP 1235 DI 10.2105/AJPH.93.8.1230 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 708CG UT WOS:000184549100016 PM 12893601 ER PT J AU Happe, MR Woodworth, PA AF Happe, MR Woodworth, PA TI Meckel's diverticulum in an adult gastrointestinal bleed SO AMERICAN JOURNAL OF SURGERY LA English DT Article ID MANAGEMENT C1 Walter Reed Army Med Ctr, Dept Med, Serv Gastroenterol, Washington, DC 20307 USA. US Army Evacuat Hosp 121st, Dept Surg, Seoul, South Korea. RP Happe, MR (reprint author), 6900 Georgia Ave,NW,Bldg 2,7th Floor, Washington, DC 20307 USA. NR 5 TC 4 Z9 5 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD AUG PY 2003 VL 186 IS 2 BP 132 EP 133 DI 10.1016/S0002-9610(03)00177-6 PG 2 WC Surgery SC Surgery GA 704YM UT WOS:000184369600010 PM 12885604 ER PT J AU Gorbach, A Simonton, D Hale, DA Swanson, SJ Kirk, AD AF Gorbach, A Simonton, D Hale, DA Swanson, SJ Kirk, AD TI Objective, real-time, intraoperative assessment of renal perfusion using infrared imaging SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE imaging techniques; infrared; kidney; reperfusion ID DELAYED GRAFT FUNCTION; ISCHEMIA-REPERFUSION INJURY; BLOOD-FLOW; TRANSPLANTED KIDNEYS; MONOCLONAL-ANTIBODY; IMMUNE-SYSTEM; ALLOGRAFT; ADHESION; IMMUNOSUPPRESSION; REDUCTION AB Allograft ischemia induces delayed graft function and is correlated with increasing rates of rejection. There is not currently a way to objectively measure the effects of ischemia in real-time, nor to relate therapies combating reperfusion injury with their intended effects. An infrared (IR) method utilizing a focal plane array detector camera was developed for real-time intraoperative IR imaging of renal allografts, and evaluated in a pilot trial to quantify perfusion in recipients of live (n=8) and cadaveric donor (n=5) allografts. Digital images were taken for 3-8 min postreperfusion. Image data were compared to ischemic time and allograft function to assess potential clinical relevance. Cold ischemic time ranged from 0.5 to 29h and was bimodally distributed between living and cadaveric donors. Renal rewarming time (RT) as determined by IR imaging correlated with cold ischemic time (p < 0.001, R-2=0.81), and predicted the subsequent return of renal function with FIT negatively correlated to the regression slopes of creatinine (p = 0.02, R-2 = 0.38) and BUN (p = 0.07, R-2 = 0.26). Intraoperative IR imaging noninvasively provides clinically relevant real-time whole kidney assessment of reperfusion. This technology may aide in the objective assessment of therapies designed to limit reperfusion injury, and allow for quantitative assessment of allograft ischemic damage. C1 NIDDKD, Transplantat & Autoimmun Branch, NIH, Bethesda, MD 20892 USA. NIH, Warren G Magnuson Clin Ctr, Dept Diagnost Radiol, Bethesda, MD 20892 USA. NIH, Warren G Magnuson Clin Ctr, Dept Nursing, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Bethesda, MD USA. RP Kirk, AD (reprint author), NIDDKD, Transplantat & Autoimmun Branch, NIH, Bethesda, MD 20892 USA. RI Kirk, Allan/B-6905-2012 NR 30 TC 23 Z9 23 U1 0 U2 2 PU BLACKWELL MUNKSGAARD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD AUG PY 2003 VL 3 IS 8 BP 988 EP 993 DI 10.1034/j.1600-6143.2003.00158.x PG 6 WC Surgery; Transplantation SC Surgery; Transplantation GA 705MQ UT WOS:000184399200014 PM 12859534 ER PT J AU Watanaveeradej, V Endy, TP Samakoses, R Kerdpanich, A Simasathien, S Polprasert, N Aree, C Vaughn, DW Ho, C Nisalak, A AF Watanaveeradej, V Endy, TP Samakoses, R Kerdpanich, A Simasathien, S Polprasert, N Aree, C Vaughn, DW Ho, C Nisalak, A TI Transplacentally transferred maternal-infant antibodies to dengue virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VARICELLA-ZOSTER VIRUS; HUMAN IGG SUBCLASSES; HEMORRHAGIC-FEVER; PLACENTAL-TRANSFER; IMMUNOGLOBULIN-G; HUMAN CONCEPTUS; INFECTION; FETAL; SERA; HEMAGGLUTINATION AB Antibodies of all four dengue virus serotypes were detected by hemagglutination inhibition (HI) in 97% of 2,000 infants' cord sera at the time of delivery. In comparison with 250 mother-infant's paired sera, we found that 53% of the infants' serum HI titers were higher than those of the mother's. The mother/infant IgG subclasses 1, 2, 3, and 4 titers were 53.1/87.0, 8.4/11.7, 0.14/0.11, and 1.1/1.0 mg/dL, respectively. In 18 months of follow-up of 100 infants studied, we observed that antibody to dengue virus disappeared in 3% by two months of age, in 19% by four months of age, in 72% by six months of age, in 99% by nine months of age, and in 100% by 12 months of age, with a half-life of 41 days. We conclude that the antibodies to dengue virus disappeared in the first year of life. We suggest that the most appropriate age for vaccination with a live-attenuated dengue vaccine in an endemic area is one year of age. C1 Phramongkutklao Hosp, Dept Pediat, Bangkok, Thailand. Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD USA. RP Watanaveeradej, V (reprint author), Phramongkutklao Hosp, Dept Pediat, 315 Rajavithee Rd, Bangkok, Thailand. FU NIAID NIH HHS [T32 AI-07526] NR 48 TC 45 Z9 47 U1 1 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2003 VL 69 IS 2 BP 123 EP 128 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 716XD UT WOS:000185054200001 PM 13677366 ER PT J AU Park, JW Klein, TA Lee, HC Pacha, LA Ryu, SH Yeom, JS Moon, SH Kim, TS Chai, JY Oh, MD Choe, KW AF Park, JW Klein, TA Lee, HC Pacha, LA Ryu, SH Yeom, JS Moon, SH Kim, TS Chai, JY Oh, MD Choe, KW TI Vivax malaria: A continuing health threat to the Republic of Korea SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PLASMODIUM-VIVAX; OUTBREAK AB Vivax malaria reemerged in the Republic of Korea in 1993. Most of the cases occurred among soldiers in the region adjacent to the Demilitarized Zone (DMZ) until 1995. To determine the rate of dispersion of vivax malaria, we evaluated its epidemiologic characteristics. Of 13,903 cases of vivax malaria reported in 2000, 40.1% (5,577) were reported among Republic of Korea military personnel, 26.2% (3,641) among veterans discharged less than two years from the military, and 33.7% (4,685) among civilians. Cases of vivax malaria have rapidly increased annually among counties bordering the DMZ, and have spread to approximately 40 km south of the DMZ. Chemoprophylaxis administered to military personnel may have been responsible for the decreasing number of cases among the Republic of Korea military population. The first mosquito-transmitted cases appeared in early June. Therefore, chemoprophylaxis should be instituted in early April to reduce the number of infected mosquitoes. Extensive intervention is warranted to reduce the spread of vivax malaria in the Republic of Korea. C1 Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea. Seoul Natl Univ, Coll Med, Dept Parasitol, Seoul 110744, South Korea. Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea. Natl Inst Hlth, Dept Virol, Lab Med Zool, Seoul, South Korea. Korean Armed Forces Med Command, Kyonggi Do, South Korea. Eighth US Army Community Hosp, Seoul, South Korea. Prevent Serv Directorate, Med Command 18th, Unit 15281, Seoul, South Korea. Gachon Med Sch, Dept Microbiol, Inchon, South Korea. RP Oh, MD (reprint author), Seoul Natl Univ, Coll Med, Dept Internal Med, 28 Yongon Dong, Seoul 110744, South Korea. RI Chai, Jong-Yil/D-5751-2012; Valle, Ruben/A-7512-2013; OI Ryu, Seungho/0000-0002-3927-8646 NR 25 TC 44 Z9 47 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 2003 VL 69 IS 2 BP 159 EP 167 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 716XD UT WOS:000185054200007 PM 13677372 ER PT J AU Pickard, AL Wongsrichanalai, C Purfield, A Kamwendo, D Emery, K Zalewski, C Kawamoto, F Miller, RS Meshnick, SR AF Pickard, AL Wongsrichanalai, C Purfield, A Kamwendo, D Emery, K Zalewski, C Kawamoto, F Miller, RS Meshnick, SR TI Resistance to antimalarials in southeast Asia and genetic polymorphisms in pfmdr1 SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID IN-VITRO SUSCEPTIBILITY; PLASMODIUM-FALCIPARUM; MEFLOQUINE RESISTANCE; HALOFANTRINE RESISTANCE; THAILAND; AMPLIFICATION; MALARIA; OVEREXPRESSION; SENSITIVITY; ARTESUNATE AB Resistance to antimalarial drugs is a public health problem worldwide. Molecular markers for drug-resistant malaria, such as pfcrt and pfmdr1 polymorphisms, could serve as useful surveillance tools. To evaluate this possibility, sequence polymorphisms in pfcrt (position 76) and pfmdr1 (positions 86, 184, 1034, 1042, and 1246) and in vitro drug sensitivities were measured for 65 Plasmodium falciparum isolates from Thailand, Myanmar, Vietnam, and Bangladesh. The pfcrt Thr76 polymorphism was present in 97% of samples, consistent with observations that chloroquine resistance is well established in this region. Polymorphisms in pfmdr1 clustered into four specific patterns: the wild type (category I), a Tyr86 polymorphism only (category II), a Phe184 polymorphism only (category III), and Phe184 in combination with Cys1034 and/or Asp1042 (category IV). Isolates in categories I and III were more sensitive to chloroquine and more resistant to mefloquine, artesunate, and artemisinin than isolates in categories II and IV (P less than or equal to 0.01). Mefloquine resistance was significantly more common in category I and III isolates than in category II and IV isolates, with a prevalence ratio of 14.95 (95% confidence interval, 3.88 to 57.56). These categories identified mefloquine resistance with a sensitivity and a specificity of 94 and 91%, respectively. The pfmdr1 gene copy number was measured by real-time PCR as a ratio of the amount of pfmdr1 DNA to the amount of lactate dehydrogenase (ldh) DNA. Eight samples had pfmdr1 DNA/ldh DNA ratios greater than or equal to3. The isolates in all 8 samples fell into categories I and III and were significantly more resistant to mefloquine, quinine, artemisinin, and artesunate and more sensitive to chloroquine than the isolates in the 57 samples with <3 copies of the gene (P &LE; 0.001). Thus, measurement of pfmdr1 mutations and gene copy number may be useful for surveillance of mefloquine-resistant malaria in Southeast Asia. C1 Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA. Univ N Carolina, Sch Med, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA. Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA. Nagoya Univ, Sch Med, Dept Int Hlth, Nagoya, Aichi 466, Japan. RP Meshnick, SR (reprint author), Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA. FU NIAID NIH HHS [AI 45426] NR 21 TC 150 Z9 152 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2003 VL 47 IS 8 BP 2418 EP 2423 DI 10.1128/AAC.47.8.2418-2423.2003 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 706JD UT WOS:000184449800006 PM 12878499 ER PT J AU Hospenthal, DR Murray, CK AF Hospenthal, DR Murray, CK TI In vitro susceptibilities of seven leptospira species to traditional and newer antibiotics SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID INTERROGANS SEROGROUP ICTEROHAEMORRHAGIAE; PENICILLIN; HAMSTERS; THERAPY; AGENTS AB Human leptospirosis is generally treated with penicillin or doxycycline. We studied the susceptibilities of 11 serovars (seven species) of Leptospira to 14 antibiotics. With the exception of chloramphenicol, all tested agents were at least as potent as penicillin and doxycycline, with the macrolide and ketolide drugs producing the lowest MICs (and minimal bactericidal concentrations). C1 Brooke Army Med Ctr, Dept Med, Infect Dis Serv, Infect Dis MCHE MDI, Ft Sam Houston, TX 78234 USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Dept Med, Infect Dis Serv, Infect Dis MCHE MDI, 3851 Roger Brook Dr, Ft Sam Houston, TX 78234 USA. NR 14 TC 39 Z9 39 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2003 VL 47 IS 8 BP 2646 EP 2648 DI 10.1128/AAC.47.8.2646-2648.2003 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 706JD UT WOS:000184449800040 PM 12878533 ER PT J AU Wu, PF Philip, R Laghumavarapu, RB Devulapalli, J Rao, DVGLN Kimball, BR Nakashima, M DeCristofano, BS AF Wu, PF Philip, R Laghumavarapu, RB Devulapalli, J Rao, DVGLN Kimball, BR Nakashima, M DeCristofano, BS TI Optical power limiting with photoinduced anisotropy of azobenzene films SO APPLIED OPTICS LA English DT Article ID CARBON NANOTUBES; REORIENTATION; PULSES; BACTERIORHODOPSIN; TEMPERATURE; LIMITATION; SCATTERING; POLYMER; STORAGE; MEDIA AB We study the power-limiting properties of photoanisotropic azobenzene films with low-power lasers. The trans-cis photoisomerization and molecular reorientation of azobenzene molecules induced by polarized laser beams result in intensity-dependent anisotropic effects. Consequently, the transmittance of the input beam that passes through the film between two crossed polarizers becomes enhanced at low intensities and clamped at high intensities. The limiting threshold is adjustable by changing the intensity of excitation beam. (C) 2003 Optical Society of America. C1 Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. Raman Res Inst, Bangalore 560080, Karnataka, India. USA, Mat Sci Team, Army Soldier Syst Ctr, Natick, MA 01760 USA. RP Wu, PF (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. EM raod@umb.edu RI Philip, Reji/E-6721-2012; Rao, Devulapalli/L-8863-2015 NR 29 TC 18 Z9 20 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD AUG 1 PY 2003 VL 42 IS 22 BP 4560 EP 4565 DI 10.1364/AO.42.004560 PG 6 WC Optics SC Optics GA 705ED UT WOS:000184382000019 PM 12916621 ER PT J AU Lam, DM AF Lam, DM TI Marie Marvingt and the development of aeromedical evacuation SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Biographical-Item DE air ambulance; medevac; aviation sanitaire; patient transport AB The development of air ambulances was one of the most important advances in military medicine in the 20(th) century. It is often forgotten today how difficult a task it was to achieve military, governmental, popular, and medical support in the early years of the century for this then-heretical concept. While many individuals were involved in this development, one of the most influential and effective proponents was Mademoiselle Marie Marvingt, of France. One of the foremost sportswomen of her clay, she was a free balloon pilot, a surgical nurse, and the third woman in the world to receive her fixed-wing pilot's license. In the area of air evacuation, she was a true visionary, ordering the construction of an air ambulance in 1912, and devoting the remainder of her long life to gaining its full acceptance in the medical armamentarium. Unlike many visionaries, she lived to see the full adoption of her proposals; her efforts should forever be remembered whenever an air ambulance is seen. C1 Univ Maryland, Sch Med, Natl Study Ctr Trauma & Emergency Med Serv, Baltimore, MD 21201 USA. USA, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Lam, DM (reprint author), PSC 79,Box 145, APO, AE 09714 USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 2003 VL 74 IS 8 BP 863 EP 868 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 706WV UT WOS:000184478800010 PM 12924762 ER PT J AU Luo, CY Leader, H Radic, Z Maxwell, DM Taylor, P Doctor, BP Saxena, A AF Luo, CY Leader, H Radic, Z Maxwell, DM Taylor, P Doctor, BP Saxena, A TI Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE acetylcholinesterase; reactivation; organophosphates; HI-6; oxime ID OXIME; CHOLINESTERASES; MONOQUATERNARY AB The inhibition of acetyleholinesterase (AChE) by organophosphorus compounds (OPs) causes acute toxicity or death of the intoxicated individual. One group of these compounds, the OP nerve agents, pose an increasing threat in the world due to their possible use in the battlefield or terrorist acts. Antidotes containing oxime compounds to reactivate the inhibited enzyme are highly valued for treatment against OP poisoning. One of these reactivators, HI-6, was shown to be significantly more effective in treating soman toxicity than other oximes. such as 2-PAM. TMB4, and obidoxime. However, HI-6 was less effective in reactivating AChE inhibited by the OP pesticide, paraoxon. In this study, the mechanism for HI-6-induced reactivation of OP-AChE conjugates was investigated using mouse mutant AChEs inhibited with different OPs including organophosphate paraoxon, and several methylphosphonates. Results indicate that the HI-6 molecule may assume two different orientations in the reactivation of AChE inhibited by organophosphate and Sp methylphosphonates. These conclusions were further corroborated by reactivation studies using an analog of HI-6 in which the bispyridinium moieties are linked by a methylene bridge rather than an ether oxygen. (C) 2003 Elsevier Science Inc. All rights reserved. C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Luo, CY (reprint author), Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. NR 15 TC 23 Z9 24 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD AUG 1 PY 2003 VL 66 IS 3 BP 387 EP 392 DI 10.1016/S0006-2952(03)00237-5 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 713NL UT WOS:000184864500004 PM 12907237 ER PT J AU Overland, J Calder, J Fetterer, F McGuire, D Morison, J Richter-Menge, J Soreide, N Walsh, J AF Overland, J Calder, J Fetterer, F McGuire, D Morison, J Richter-Menge, J Soreide, N Walsh, J TI Search workshop on large-scale atmosphere-cryosphere observations SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Editorial Material ID ARCTIC-OCEAN; ICE; VARIABILITY; OSCILLATION; ATTRIBUTION AB A multivariate, multidisciplinary Arctic observing system is key to the resolution of climate change issues. C1 NOAA, Pacific Marine Environm Lab, Seattle, WA 98115 USA. NOAA, Off Ocean & Atmospher Res, Silver Spring, MD USA. Univ Colorado, CIRES, Boulder, CO 80309 USA. Univ Alaska, Fairbanks, AK 99701 USA. Univ Washington, Polar Sci Ctr, Seattle, WA 98195 USA. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Univ Illinois, Dept Atmospher Sci, Urbana, IL 61801 USA. RP Overland, J (reprint author), NOAA, Pacific Marine Environm Lab, 7600 Sand Point Way NE, Seattle, WA 98115 USA. NR 14 TC 3 Z9 3 U1 1 U2 1 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD AUG PY 2003 VL 84 IS 8 BP 1077 EP + DI 10.1175/BAMS-84-8-1077 PG 7 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 712ZJ UT WOS:000184829200021 ER PT J AU Santi, M Mena, H Wong, K Koeller, K Olsen, C Rushing, EJ AF Santi, M Mena, H Wong, K Koeller, K Olsen, C Rushing, EJ TI Spinal cord malignant astrocytomas - Clinicopathologic features in 36 cases SO CANCER LA English DT Article DE astrocytoma; glioblastoma multiforme; spinal cord; prognostic features ID GLIOBLASTOMA-MULTIFORME; PROGNOSTIC-SIGNIFICANCE; TUMORS; CHILDREN; GRADE; CHEMOTHERAPY; RADIOTHERAPY; MANAGEMENT; P53; METASTASES AB BACKGROUND. Malignant astrocytomas of the spinal cord are uncommon neoplasms with a dismal prognosis. To the authors' knowledge, little information has been published to date regarding the prognostic impact of clinicopathologic factors. METHODS. The authors studied 36 cases to investigate the prognostic effect of the World Health Organization (WHO) tumor grade, tumor localization, cell proliferative activity, p53 expression, and therapy. RESULTS. Sixteen patients (44%) under-went biopsy alone, 11 (31%) underwent subtotal resection, and 7 (19%) underwent macroscopic total excision. For two patients, there were no data available regarding surgical treatment. Among the 36 patients (mean age, 32.4 years), there were 23 males (63%) and 13 (36%) females. Their initial biopsies showed 21 (63%) glioblastoma. multiforme (GBM) cases (WHO Grade 4), 13 (36%) anaplastic astrocytomas (AA) (WHO Grade 3), and 2 (6%) astrocytomas (A) (WHO Grade 2). After initial surgery, 10 (29%) patients were treated with radiation therapy alone and 7 (19%) received radiation therapy with chemotherapy. Patterns of disease recurrence included extraneural metastases (two cases), brain metastases (five cases), local extension (one case), and diffuse spread along the neuraxis (six cases). Two A (100%) and six AA (46%) cases progressed to GBM. The overall median survival time was 33 months (range, 24-42 months) for A, 10 months (range, 1-84 months) for AA, and 10 months (range, 1-43 months) for GBM. CONCLUSIONS. Patients older than 40 years have a shorter survival period compared with younger patients. There is a high risk of central nervous system dissemination in patients with this disease. (C) 2003 American Cancer Society. C1 USA, Med Corps, Armed Forces Inst Pathol, Dept Neuropathol & Ophthalm Pathol, Washington, DC 20306 USA. Natl Childrens Hosp, Med Ctr, Dept Pathol, Washington, DC USA. Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Rushing, EJ (reprint author), USA, Med Corps, Armed Forces Inst Pathol, Dept Neuropathol & Ophthalm Pathol, Washington, DC 20306 USA. NR 45 TC 50 Z9 53 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD AUG 1 PY 2003 VL 98 IS 3 BP 554 EP 561 DI 10.1002/cncr.11514 PG 8 WC Oncology SC Oncology GA 702VU UT WOS:000184246000014 PM 12879473 ER PT J AU Xu, LL Shi, YH Petrovics, G Sun, C Makarem, M Zhang, W Sesterhenn, IA McLeod, DG Sun, L Moul, JW Srivastava, S AF Xu, LL Shi, YH Petrovics, G Sun, C Makarem, M Zhang, W Sesterhenn, IA McLeod, DG Sun, L Moul, JW Srivastava, S TI PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression SO CANCER RESEARCH LA English DT Article ID TUMOR-SUPPRESSOR GENES; LIGASE NEDD4; ALLELIC LOSS; WW DOMAIN; IDENTIFICATION; RECEPTOR; LNCAP; UBIQUITINATION; METASTASIS; DELETION AB PMEPA1 was originally identified as a highly androgen-induced gene by serial analysis of gene expression in androgen-treated LNCaP prostate cancer (CaP) cells. PMEPA1 expression is prostate abundant and restricted to prostatic epithelial cells. PMEPA1-encoded protein shows high sequence homology to a mouse N4wbp4-encoded protein that binds to Nedd4 protein, an E3 ubiquitin-protein ligase involved in ubiquitin-dependent, proteasome-mediated protein degradation. Studies from our and other laboratories have suggested the role of PMEPA1 in cell growth regulation as noted by androgen induction of PMEPA1 expression, elevated PMEPA1 expression in nontumorigenic revertants of tumor cell lines after chromosome 8p transfer, and PMEPA1 expression alterations (up- or down-regulation) in human tumors. Here, we demonstrate that PMEPA1 protein through its PY motifs interacts with WW domains of the human NEDD4 protein. Exogenous expression of PMEPA1, in widely used CaP cell lines DU145, PC3, LNCaP, and LNCaP sublines (C4, C4-2, and C4-2B), conferred cell growth inhibition, and at least one of the PY motifs of PMEPA1 may be involved in its cell growth inhibitory functions. Quantitative expression analysis of PMEPA1 in paired normal and tumor cells of 62 patients with primary CaP revealed tumor cells associated decreased expression in 40 of 62 patients that were significantly associated with higher pathologic stage and serum prostate-specific antigen. Taken together, PMEPA1 negatively regulates growth of androgen responsive or refractory CaP cells, and these functions may be mediated through the interaction of PMEPA1 with the NEDD4 protein involved in the ubiquitin-proteasome pathway. Loss or reduced PMEPA1 expression in CaP further suggests for its role in prostate tumorigenesis. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Serv Urol, Washington, DC 20307 USA. Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20307 USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. NR 33 TC 67 Z9 72 U1 1 U2 4 PU AMER ASSOC CANCER RESEARCH PI BIRMINGHAM PA PO BOX 11806, BIRMINGHAM, AL 35202 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD AUG 1 PY 2003 VL 63 IS 15 BP 4299 EP 4304 PG 6 WC Oncology SC Oncology GA 708JB UT WOS:000184562500002 PM 12907594 ER PT J AU Parysow, P Wang, GX Gertner, G Anderson, AB AF Parysow, P Wang, GX Gertner, G Anderson, AB TI Spatial uncertainty analysis for mapping soil erodibility based on joint sequential simulation SO CATENA LA English DT Article DE soil erodibility; USLE; joint sequential simulation; uncertainty analysis ID PROJECTIONS AB Soil erodibility (susceptibility Of soil to be lost to erosion) is one of the components of the universal soil loss equation (USLE). In the USLE, erodibility is known as the K factor, which in turn is a function of these soil properties: particle size distribution, organic matter content, structure, and permeability. The traditional approach for estimating soil erodibility does not account for spatial variability of individual soil properties or spatial correlation among those properties. Our objectives in this study were to evaluate the use of joint sequential simulation for mapping soil credibility, as well as to partition the individual and joint variance contribution of soil properties for predicting soil erodibility. We collected 192 usable soil samples across Fort Hood, Texas in the summer of 1999. For each of those samples, we obtained an estimate of particle size distribution, organic matter content, structure, permeability, and calculated soil erodibility. We carried out both independent and joint sequential simulation to generate spatially explicit predictions and variance of all soil properties as well as covariance between pairs of soil properties for each cell within our simulation area. We used the program GCOSIM3D to conduct those simulations. On average, joint sequential simulation resulted in a K factor variance of less than half the variance obtained from independent simulation. Using the results from joint sequential simulation, we partitioned the contribution of each soil property and pair of properties using first-order Taylor series expansion of the soil erodibility function. Individually, Very-Fine-Sand-and-Silt contributed the most (46.19%), whereas Structure contributed the least (6.53%) to the K factor variance. Jointly, Permeability/Structure contributed the most (9.32%), whereas Sand/Very-Fine-Sand-and-Silt caused the largest reduction (- 19.19%) in the K factor variance. We conclude that joint sequential simulation provided approximately twice as much precision as independent simulation for the spatially explicit prediction of soil erodibility. Likewise, first-order Taylor series expansion offered an accurate approach for partitioning the individual and joint contribution of soil properties to soil erodibility variance. This partitioning allowed us to identify large sources of uncertainty and suggest efficient approaches for further improving the precision of K value predictions. (C) 2003 Elsevier Science B.V. All rights reserved. C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. No Arizona Univ, Sch Forestry, Flagstaff, AZ 86011 USA. USA, Construct Engn Res Labs, Nat Resources Assessment & Management Div, Champaign, IL 61826 USA. RP Gertner, G (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. NR 34 TC 34 Z9 37 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0341-8162 J9 CATENA JI Catena PD AUG 1 PY 2003 VL 53 IS 1 BP 65 EP 78 DI 10.1016/S0341-8162(02)00198-4 PG 14 WC Geosciences, Multidisciplinary; Soil Science; Water Resources SC Geology; Agriculture; Water Resources GA 703YM UT WOS:000184310800004 ER PT J AU Yue, P Atwood, JE Froelicher, V AF Yue, P Atwood, JE Froelicher, V TI Watch the P wave - It can change! SO CHEST LA English DT Editorial Material ID OBSTRUCTIVE PULMONARY-DISEASE; RIGHT ATRIAL ENLARGEMENT; ELECTROCARDIOGRAPHIC CRITERIA; ECHOCARDIOGRAPHY; EXACERBATION C1 Stanford Univ, Stanford, CA 94305 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Froelicher, V (reprint author), Palo Alto Vet Affairs Med Ctr, 3801 Miranda Ave,Bldg 100,Room E2-441, Palo Alto, CA 94304 USA. NR 15 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD AUG PY 2003 VL 124 IS 2 BP 424 EP 426 DI 10.1378/chest.124.2.424 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 712MG UT WOS:000184801000003 PM 12907522 ER PT J AU Creamer, KM AF Creamer, KM TI Family-witnessed resuscitation SO CHEST LA English DT Letter ID CARDIOPULMONARY-RESUSCITATION; EMERGENCY C1 Walter Reed Army Med Ctr, Dept Pediat, Pediat Intens Care Unit, MHCL,KCC, Washington, DC 20307 USA. RP Creamer, KM (reprint author), Walter Reed Army Med Ctr, Dept Pediat, Pediat Intens Care Unit, MHCL,KCC, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 4 TC 1 Z9 1 U1 1 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD AUG PY 2003 VL 124 IS 2 BP 769 EP 770 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 712MG UT WOS:000184801000061 PM 12907577 ER PT J AU McClenathan, BM Uyehara, CFT Torrington, KG AF McClenathan, BM Uyehara, CFT Torrington, KG TI Family-witnessed resuscitation - Response SO CHEST LA English DT Letter C1 Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Torrington, KG (reprint author), Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD AUG PY 2003 VL 124 IS 2 BP 770 EP 770 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 712MG UT WOS:000184801000062 ER PT J AU Kennedy, JE Clement, PF Curtiss, G AF Kennedy, JE Clement, PF Curtiss, G TI WAIS-III processing speed index scores after TBI: The influence of working memory, psychomotor speed and perceptual processing SO CLINICAL NEUROPSYCHOLOGIST LA English DT Article ID TRAUMATIC BRAIN-INJURY; CLOSED-HEAD INJURY; INTELLIGENCE; INDICATORS; CHILDREN AB This study investigates the extent to which working memory, motor speed and perceptual processing speed influence Wechsler Adult Intelligence Scale-III (WAIS-III) Processing Speed Index (PSI) scores. Sixty-eight adult outpatients with Traumatic Brain Injury (TBI) of varying severity and complete data on all outcome measures were identified. Two cases with outlying values on one outcome measure were omitted from the final sample. Working memory was measured by the Working Memory Index score from the WAIS-III. Motor speed was measured as score on the Halstead-Reitan Finger Oscillation Test (finger tapping) and perceptual processing as score on the Trail Making Test-Part B. In hierarchical multiple regression analyses, working memory accounted for 10% of the variance in PSI scores, whereas motor speed only accounted for 3%. An independent measure of perceptual processing, Trail Making Test-B, accounted for 26% of the variance in WAIS-III PSI scores. The total variance accounted for by the three factors was 56%. Findings confirm that the WAIS-III PSI scores of individuals who have received a TBI reflect perceptual processing speed, with an additional component attributable to working memory. Motor speed made only a small contribution to WAIS-III PSI scores in the present sample. C1 Wilford Hall USAF Med Ctr, Def & Vet Brain Injury Ctr, San Antonio, TX 78227 USA. Brooke Army Med Ctr, ATTN MCHE CP, Ft Sam Houston, TX 78234 USA. James A Haley Vet Hosp, Def & Vet Brain Injury Ctr, Tampa, FL 33612 USA. Univ S Florida, Dept Psychiat & Behav Med, Tampa, FL USA. RP Kennedy, JE (reprint author), Wilford Hall USAF Med Ctr, Def & Vet Brain Injury Ctr, POB 27376, San Antonio, TX 78227 USA. NR 19 TC 20 Z9 21 U1 1 U2 3 PU SWETS ZEITLINGER PUBLISHERS PI LISSE PA P O BOX 825, 2160 SZ LISSE, NETHERLANDS SN 0920-1637 J9 CLIN NEUROPSYCHOL JI Clin. Neuropsychol. PD AUG PY 2003 VL 17 IS 3 BP 303 EP 307 DI 10.1076/clin.17.3.303.18091 PG 5 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA 748DP UT WOS:000186847100002 PM 14704894 ER PT J AU Shi, FY Svendsen, IA Kirby, JT Smith, JM AF Shi, FY Svendsen, IA Kirby, JT Smith, JM TI A curvilinear version of a quasi-3D nearshore circulation model SO COASTAL ENGINEERING LA English DT Article DE nearshore circulation model; numerical model; curvilinear coordinates; finite difference method; wave-induced circulation ID UNIFORM LONGSHORE CURRENTS; SHALLOW-WATER; DISPERSION; FLOW; EQUATIONS; WAVES AB A curvilinear version of the nearshore circulation model SHORECIRC is developed based on the quasi-3D nearshore circulation equations derived by Putrevu and Svendsen [Eur. J. Mech. 18 (1999) 409-427]. We use a generalized coordinate transformation and re-derive the equations in tensor-invariant forms. The contravatiant component technique is used to simplify both the transformed equations and boundary conditions. A high-order finite-difference scheme with a staggered grid in the image domain is adopted for the numerical model. Very good convergence rates with both grid refinement and time refinement are obtained in a simple convergence test. The model is then applied to four cases involving either a non-orthogonal quadrilateral grid or a generalized curvilinear grid. The versatility of the curvilinear model in dealing with curved shorelines, nearshore breakwaters and other complicated geometries is demonstrated in the test cases. The accuracy of the model is shown in the paper through model/data comparisons in two of the case studies. (C) 2003 Elsevier B.V. All rights reserved. C1 Univ Delaware, Ctr Appl Coastal Res, Ocean Engn Lab, Newark, DE 19716 USA. Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Shi, FY (reprint author), Univ Delaware, Ctr Appl Coastal Res, Ocean Engn Lab, Newark, DE 19716 USA. NR 40 TC 24 Z9 25 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD AUG PY 2003 VL 49 IS 1-2 BP 99 EP 124 DI 10.1016/S0378-3839(03)00049-8 PG 26 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 717UR UT WOS:000185109600006 ER PT J AU Duffy, PE Fried, M AF Duffy, PE Fried, M TI Plasmodium falciparum adhesion in the placenta SO CURRENT OPINION IN MICROBIOLOGY LA English DT Review ID CHONDROITIN SULFATE-A; ERYTHROCYTE-MEMBRANE PROTEIN-1; INFECTED ERYTHROCYTES; HYALURONIC-ACID; VAR GENES; PREGNANT-WOMEN; MALARIA; EXPRESSION; RECEPTOR; BINDING AB Plasmodium falciparum parasites sequester in the human placenta, and placental malaria is associated with disease and death of both mother and child. Placental isolates of P. falciparum uniformly bind to chondroitin sulfate A on the syncytiotrophoblast. Forms of the variant surface antigen PfEMP1 that bind chondroitin sulfate A in vitro (PfEMP1(varCSA)) are highly conserved in many field isolates. Two related forms of PfEMP1(varCSA) are commonly expressed by placental isolates, but these are also transcribed by most non-placental isolates. PfEMP1(varCSA) gene transcription is not upregulated when parasites are selected to bind chondroitin sulfate A, but other PfEMP1 forms may be upregulated. Young ring-stage parasites derived from chondroitin sulfate A-binding isolates may also bind to the endothelium through a process that does not involve PfEMP1 or chondroitin sulfate A. Adhesins and other surface proteins of placental parasites are targets of naturally occurring antibodies associated with protection and therefore could be used to develop vaccines that prevent malaria in pregnancy. C1 Seattle Biomed Res Inst, Malaria Antigen Discovery Program, Seattle, WA 98109 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, Malaria Antigen Discovery Program, 4 Nickerson St,STE 200, Seattle, WA 98109 USA. FU NIAID NIH HHS [AI43680, AI52059] NR 31 TC 41 Z9 41 U1 0 U2 0 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 1369-5274 J9 CURR OPIN MICROBIOL JI Curr. Opin. Microbiol. PD AUG PY 2003 VL 6 IS 4 BP 371 EP 376 DI 10.1016/S1369-5274(03)00090-0 PG 6 WC Microbiology SC Microbiology GA 718YA UT WOS:000185173000010 PM 12941407 ER PT J AU Kupres, KA Krivda, SJ Turiansky, GW AF Kupres, KA Krivda, SJ Turiansky, GW TI Numerous asymptomatic facial papules and multiple pulmonary cysts: A case of Birt-Hogg-Dube syndrome SO CUTIS LA English DT Article ID SPONTANEOUS PNEUMOTHORAX; KIDNEY NEOPLASIA; FIBROFOLLICULOMAS; TRICHODISCOMAS; ACROCHORDONS C1 San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. Natl Capital Consortium Dermatol Residency Progra, Bethesda, MD USA. Natl Capital Consortium Dermatol Residency Progra, Washington, DC USA. RP Kupres, KA (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. NR 17 TC 8 Z9 8 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD AUG PY 2003 VL 72 IS 2 BP 127 EP 131 PG 5 WC Dermatology SC Dermatology GA 713GX UT WOS:000184850100006 PM 12953936 ER PT J AU Altman, CE Hamill, RL Elston, DM AF Altman, CE Hamill, RL Elston, DM TI Metastatic aggressive digital papillary adenocarcinoma SO CUTIS LA English DT Article ID SWEAT GLAND TUMORS; CARCINOEMBRYONIC ANTIGEN; NEOPLASMS; ADENOMA AB A 52-year-old white man presented with 2 complex cystic masses in his left inguinal region. On histopathologic examination, an asymptomatic nodule between the third and fourth metatarsal heads was diagnosed as an aggressive digital papillary adenocarcinoma (ADPAca), and the complex cysts from the groin represented metastatic disease from the primary acral tumor. The primary tumor was focally positive for immunoreactivity to ferritin antibody, an immunohistologic. marker for sweat gland malignancies. Ferritin antibody may prove useful in the diagnosis of aggressive digital papillary adenoma (ADPA) and ADPAca. C1 Brooke Army Med Ctr, Dept Dermatol, Ft Sam Houston, TX 78234 USA. Eisenhower Army Med Ctr, Dept Pathol, Ft Gordon, GA USA. Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. Geisinger Med Ctr, Dept Lab Med, Danville, PA 17822 USA. RP Altman, CE (reprint author), Brooke Army Med Ctr, Dept Dermatol, Bldg 3600, Ft Sam Houston, TX 78234 USA. NR 12 TC 9 Z9 9 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD AUG PY 2003 VL 72 IS 2 BP 145 EP 147 PG 3 WC Dermatology SC Dermatology GA 713GX UT WOS:000184850100010 PM 12953940 ER PT J AU Della-Giustina, D Denny, M AF Della-Giustina, D Denny, M TI Ectopic pregnancy SO EMERGENCY MEDICINE CLINICS OF NORTH AMERICA LA English DT Article ID HUMAN CHORIONIC-GONADOTROPIN; SINGLE-DOSE METHOTREXATE; EARLY INTRAUTERINE PREGNANCY; SERUM HCG LEVEL; TRANSVAGINAL SONOGRAPHY; TUBAL PREGNANCY; VAGINAL ULTRASONOGRAPHY; EMERGENCY PHYSICIANS; HETEROTOPIC PREGNANCY; SYSTEMIC METHOTREXATE AB Ectopic pregnancy is a high-risk diagnosis that is increasing in frequency and is still commonly missed in the emergency department. The emergency physician needs a high index of suspicion and must understand that the history, physical examination, and a single quantitative level of beta-human chorionic gonadotropin cannot reliably rule out an ectopic pregnancy. This article reviews the clinical, laboratory, and ultrasonographic findings that help the emergency physician diagnose an ectopic pregnancy. An approach to the patient who presents to the emergency department with suspected ectopic pregnancy and the management of the patient diagnosed with an ectopic pregnancy are discussed. C1 Madigan Army Med Ctr, Dept Emergency Med, Tacoma, WA 98431 USA. USA, Washington, DC 20310 USA. Univ Washington, Sch Med, Seattle, WA 98195 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Della-Giustina, D (reprint author), Madigan Army Med Ctr, Dept Emergency Med, Tacoma, WA 98431 USA. NR 97 TC 32 Z9 33 U1 1 U2 3 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0733-8627 J9 EMERG MED CLIN N AM JI Emerg. Med. Clin. N. Am. PD AUG PY 2003 VL 21 IS 3 BP 565 EP + DI 10.1016/S0733-8627(03)00036-1 PG 21 WC Emergency Medicine SC Emergency Medicine GA 716VM UT WOS:000185050300002 PM 12962347 ER PT J AU Della-Giustina, K Chow, G AF Della-Giustina, K Chow, G TI Medications in pregnancy and lactation SO EMERGENCY MEDICINE CLINICS OF NORTH AMERICA LA English DT Article ID BREAST-FED INFANT; CONGENITAL-ABNORMALITIES; DRUG-THERAPY; MILK; EXCRETION; MOTHER; WOMEN; DISPOSITION; FENTANYL; COCAINE AB Emergency physicians commonly prescribe medications to patients who are either pregnant or are breastfeeding. Because of the potential harm that medications may cause the fetus or the breastfed child, physicians are reluctant to prescribe a variety of medications or improperly counsel a mother to discontinue breastfeeding. This article reviews the physiology and other factors that one should consider when prescribing medications to these patients. In terms of specific medications, the authors review the Food and Drug Administration (FDA) safety categorizations for use in pregnancy, but few of the specific medications commonly prescribed for pregnant patients are included in the well-defined FDA categories. The authors also review several classes and specific medications commonly considered for use by breastfeeding patients for which the use in lactation is not well defined. C1 Madigan Army Med Ctr, Dept Pediat, Tacoma, WA 98431 USA. USA, Washington, DC 20310 USA. Madigan Army Med Ctr, Dept Obstet & Gynecol, Tacoma, WA 98431 USA. RP Della-Giustina, K (reprint author), Madigan Army Med Ctr, Dept Pediat, Tacoma, WA 98431 USA. NR 91 TC 10 Z9 12 U1 1 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0733-8627 J9 EMERG MED CLIN N AM JI Emerg. Med. Clin. N. Am. PD AUG PY 2003 VL 21 IS 3 BP 585 EP + DI 10.1016/S0733-8627(03)00037-3 PG 30 WC Emergency Medicine SC Emergency Medicine GA 716VM UT WOS:000185050300003 PM 12962348 ER PT J AU Abbrescia, K Sheridan, B AF Abbrescia, K Sheridan, B TI Complications of second and third trimester pregnancies SO EMERGENCY MEDICINE CLINICS OF NORTH AMERICA LA English DT Article ID PRETERM PREMATURE RUPTURE; OXYTOCIN ANTAGONIST ATOSIBAN; MAGNESIUM-SULFATE THERAPY; ABRUPTIO PLACENTAE; CLINICAL-SIGNIFICANCE; ANTIBIOTIC-THERAPY; PERINATAL OUTCOMES; UNITED-STATES; VASA PREVIA; RISK-FACTOR AB The second and third trimester of pregnancy is a period of extensive physical growth and maturation of the fetus. Unfortunately, it is also a period that is marked by complications that can be life threatening for both the mother and fetus. The top three complications that affect pregnancy are hemorrhage, infection, and the hypertensive diseases of pregnancy. This article focuses on preterm labor, premature rupture of membranes, chorioamnionitis, bleeding in later pregnancy, and the hypertensive diseases of pregnancy. C1 USA, Washington, DC 20310 USA. Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Dept Emergency Med, San Antonio, TX USA. RP Abbrescia, K (reprint author), MCHE EM, Dept Emergency Med, 3851 Roger Brooker Dr, Ft Sam Houston, TX 78234 USA. NR 56 TC 2 Z9 2 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0733-8627 J9 EMERG MED CLIN N AM JI Emerg. Med. Clin. N. Am. PD AUG PY 2003 VL 21 IS 3 BP 695 EP + DI 10.1016/S0733-8627(03)00043-9 PG 17 WC Emergency Medicine SC Emergency Medicine GA 716VM UT WOS:000185050300009 PM 12962354 ER PT J AU Daniels, RV McCuskey, C AF Daniels, RV McCuskey, C TI Abnormal vaginal bleeding in the nonpregnant patient SO EMERGENCY MEDICINE CLINICS OF NORTH AMERICA LA English DT Article ID MENSTRUAL BLOOD-LOSS; WOMEN; MENORRHAGIA; MANAGEMENT; FEMALE; GIRLS; DIAGNOSIS; CHILDREN; THERAPY; INJURY AB Abnormal vaginal bleeding is a common presenting complaint to most emergency departments. Vaginal bleeding can be the cause of significant morbidity and mortality in nonpregnant patients. Vaginal bleeding can also herald serious underlying problems related to malignancy chronic illness, and sexual abuse. This article discusses causes of bleeding in prepubertal, reproductive-age, and postmenopausal patients along with various management approaches and treatment options. C1 USA, Washington, DC 20310 USA. Texas A&M Univ, Coll Med, College Stn, TX 77843 USA. Scott & White Mem Hosp & Clin, Dept Emergency Med, Temple, TX 76508 USA. RP Daniels, RV (reprint author), USA, Washington, DC 20310 USA. NR 51 TC 4 Z9 4 U1 1 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0733-8627 J9 EMERG MED CLIN N AM JI Emerg. Med. Clin. N. Am. PD AUG PY 2003 VL 21 IS 3 BP 751 EP + DI 10.1016/S0733-8627(03)00045-2 PG 23 WC Emergency Medicine SC Emergency Medicine GA 716VM UT WOS:000185050300012 PM 12962357 ER PT J AU Baird, JK Basri, H Weina, P Maguire, JD Barcus, MJ Picarema, H Elyazar, IRF Ayomi, E Sekartuti AF Baird, JK Basri, H Weina, P Maguire, JD Barcus, MJ Picarema, H Elyazar, IRF Ayomi, E Sekartuti TI Adult Javanese migrants to Indonesian Papua at high risk of severe disease caused by malaria SO EPIDEMIOLOGY AND INFECTION LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; PLACEBO-CONTROLLED TRIAL; AFRICAN CHILDREN; ENDEMIC MALARIA; IRIAN-JAYA; AGE; PROPHYLAXIS; PROTECTION; IMMUNITY; EXPOSURE AB Migrants from Java arrive in hyperendemic Papua, Indonesia lacking exposure to endemic malaria. We evaluated records of evacuation to hospital with a diagnosis of severe malaria from a transmigration village in northeastern Papua. During the first 30 months, 198 residents with severe disease were evacuated (7.5 evacuations/100 person-years). During this period the risk of evacuation for adults (>15 years of age) was 2.8. (95% CI=2.1-3.8; P<0.0001) relative to children, despite apparently equal exposure to risk of infection. Relative risk (RR) for adults was greatest during the first 6 months (RR>16; 95% CIgreater than or equal to2.0-129; P=0.0009), and diminished during the second 6 months (RR=9.4; 95% CI=2.7-32.8; P<0.0001) and the third 6 months (RR 3.7; 95% CI=1.7-7.9; P=0.0004). During the next two 6-month intervals, the RR for adults was 1.6 and 1.5 (95% CI range 0.8-2.6; P<0.18). Adults lacking chronic exposure were far more likely to progress to severe disease compared to children during initial exposure, but not after chronic exposure to infection. C1 USN, Med Res Unit 2, Jakarta, Indonesia. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USN, Med Res Unit 2, Satellite Lab, Jayapura, Papua, Indonesia. Prov Hlth Res Ctr, Jayapura, Papua, Indonesia. Minist Hlth, Natl Hlth Res Ctr, Jakarta, Indonesia. RP Baird, JK (reprint author), USN, Parasit Dis Program, Med Res Unit 2, Amer Embassy, FPO, AP 96520 USA. RI Weina, Peter/A-2120-2011 NR 47 TC 9 Z9 9 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH ST, NEW YORK, NY 10011-4221 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD AUG PY 2003 VL 131 IS 1 BP 791 EP 797 DI 10.1017/S0950268803008422 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 716AF UT WOS:000185006100026 PM 12948380 ER PT J AU Frattarelli, JL Levi, AJ Miller, BT Segars, JH AF Frattarelli, JL Levi, AJ Miller, BT Segars, JH TI A prospective assessment of the predictive value of basal antral follicles in in vitro fertilization cycles SO FERTILITY AND STERILITY LA English DT Article DE in vitro fertilization; basal antral follicle count; pregnancy; cancellation rate; ovarian response; ovarian reserve; predictive value; clinical outcome; review ID REPRODUCTIVE TECHNOLOGY CYCLES; STIMULATING-HORMONE LEVELS; CITRATE CHALLENGE TEST; DAY 3 ESTRADIOL; INVITRO FERTILIZATION; OVARIAN RESPONSIVENESS; EMBRYO-TRANSFER; NUMBER; AGE; ULTRASOUND AB Objective: To determine the predictive value and define threshold values for basal antral follicle count in patients undergoing IVF. Design: Prospective cohort analysis. Setting: Tertiary care center. Patient(s): Two hundred eighty-nine patients. Intervention(s): Transvaginal ultrasonography before starting gonadotropin administration. Main Outcome Measure(s): Number of oocytes retrieved, basal hormone levels, and cycle outcomes. Result(s): Pregnant patients had significantly more antral follicles (13.8+/-7.5 vs. 12.4+/-10.0). Patients in whom cycles were canceled had significantly fewer antral follicles (7.6+/-4.8 vs. 13.7+/-8.8). Antral follicle count significantly correlated with most prestimulation and poststimulation IVF variables. Threshold analysis demonstrated a lower pregnancy rate (23.5% vs. 57.6%) and a higher cancellation rate (41% vs. 6.4%) associated with having four or fewer antral follicles. Conclusion(s): The basal antral follicle count identified patients who responded poorly to IVF stimulation. Having four or fewer antral follicles was associated with a high cancellation rate (41%) and, in patients without a cancelled cycle, a low pregnancy rate (23%). However, no antral follicle count absolutely predicted pregnancy or cycle cancellation. (Fertil Steril(R) 2003;80:350-5. (C) 2003 by American Society for Reproductive Medicine.) C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. Reprod Med Associates, Bethesda, MD USA. Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, USN, Med Ctr,Combined Fed Program Reprod Endocrinol, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Pediat & Reprod Endocrinol Branch, USN,Med Ctr, Bethesda, MD 20814 USA. RP Frattarelli, JL (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 25 TC 57 Z9 59 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD AUG PY 2003 VL 80 IS 2 BP 350 EP 355 DI 10.1016/S0015-0282(03)00664-2 PG 6 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 709PZ UT WOS:000184634700021 PM 12909498 ER PT J AU Wu, XL Larson, SR Hu, ZM Palazzo, AJ Jones, TA Wang, RRC Jensen, KB Chatterton, NJ AF Wu, XL Larson, SR Hu, ZM Palazzo, AJ Jones, TA Wang, RRC Jensen, KB Chatterton, NJ TI Molecular genetic linkage maps for allotetraploid Leymus wildryes (Gramineae : Triticeae) SO GENOME LA English DT Article DE AFLP; perennial grasses; RFLP; STS; SSR ID BARLEY HORDEUM-VULGARE; SEGREGATION DISTORTION; DEVELOPMENTAL GENE; AFLP MARKERS; RFLP MAP; WHEAT; GENOME; POACEAE; MAIZE; RICE AB Molecular genetic maps were constructed for two full-sib populations, TTC1 and TTC2, derived from two Leymus triticoides x Leymus cinereus hybrids and one common Leymus triticoides tester. Informative DNA markers were detected using 21 EcoRI-MseI and 17 PstI-MseI AFLP primer combinations, 36 anchored SSR or STS primer pairs, and 9 anchored RFLP probes. The 164-sib TTC1 map includes 1069 AFLP markers and 38 anchor loci in 14 linkage groups spanning 2001 cM. The 170-sib TTC2 map contains 1002 AFLP markers and 36 anchor loci in 14 linkage groups spanning 2066 cM. Some 488 homologous AFLP loci and 24 anchor markers detected in both populations showed similar map order. Thus, 1583 AFLP markers and 50 anchor loci were mapped into 14 linkage groups, which evidently correspond to the 14 chromosomes of allotetraploid Leymus (2n = 4x = 28). Synteny of two or more anchor markers from. each of the seven homoeologous wheat and barley chromosomes was detected for 12 of the 14 Leymus linkage groups. Moreover, two distinct sets of genome-specific STS markers were identified in these allotetraploid Leymus species. These Leymus genetic maps and populations will provide a useful system to evaluate the inheritance of functionally important traits of two divergent perennial grass species. C1 Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100101, Peoples R China. USA, Cold Reg Res & Engn Lab, Corps Engineers, Ctr Res Dev & Engn, Hanover, NH 03755 USA. RP Larson, SR (reprint author), Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. NR 74 TC 42 Z9 48 U1 0 U2 5 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA, ONTARIO K1A 0R6, CANADA SN 0831-2796 J9 GENOME JI Genome PD AUG PY 2003 VL 46 IS 4 BP 627 EP 646 DI 10.1139/G03-048 PG 20 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 711RR UT WOS:000184755300012 PM 12897871 ER PT J AU Westerfeld, D Suchalkin, S Kisin, M Belenky, G Bruno, J Tober, R AF Westerfeld, D Suchalkin, S Kisin, M Belenky, G Bruno, J Tober, R TI Experimental study of optical gain and loss in 3.4-3.6 mu m interband cascade lasers SO IEE PROCEEDINGS-OPTOELECTRONICS LA English DT Article; Proceedings Paper CT 5th International Conference on Mid-Infrared Optoelectronics Materials and Devices CY SEP 08-11, 2002 CL ANNOPOLIS, MARYLAND ID QUANTUM-DOT LASERS AB The optical gain and loss of lasers operating over the wavelength range of 3.4 to 3.6 mum were measured using the Hakki-Paoli technique. The optical loss was found to increase with increasing temperature, from 38 cm(-1) at 80 K to 62 cm-1 at 200 K for a typical sample. Above the maximum continuous-wave (CW) lasing temperature, the modal gain was observed to saturate before the device reached threshold. The reason for the gain saturation is the active area overheating in the CW mode. Some of the samples exhibited strong mode-grouping effects. These effects indicate the presence of 'leaky modes' in these structures and lead to a significant reduction of net gain at certain frequencies. C1 SUNY Stony Brook, Dept Elect Engn, Stony Brook, NY 11794 USA. Maxion Technol Inc, Hyattsville, MD 20782 USA. Army Res Lab, Adelphi, MD 20873 USA. RP Westerfeld, D (reprint author), SUNY Stony Brook, Dept Elect Engn, Light Engn Bldg, Stony Brook, NY 11794 USA. NR 13 TC 5 Z9 6 U1 0 U2 2 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1350-2433 J9 IEE P-OPTOELECTRON JI IEE Proc.-Optoelectron. PD AUG PY 2003 VL 150 IS 4 BP 293 EP 297 DI 10.1049/ip-opt:20030539 PG 5 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA 744KN UT WOS:000186628700005 ER PT J AU Sarney, WL Leavitt, RP AF Sarney, WL Leavitt, RP TI Strain and interfacial bond type effects on structural quality of InAs/Ga(As,Sb) superlattices grown on InAs substrates SO IEE PROCEEDINGS-OPTOELECTRONICS LA English DT Article; Proceedings Paper CT 5th International Conference on Mid-Infrared Optoelectronics Materials and Devices CY SEP 08-11, 2002 CL ANNOPOLIS, MARYLAND ID INTERBAND CASCADE LASERS; INAS/GASB SUPERLATTICES; ROUGHNESS AB A series of InAs/Ga(As,Sb) superlattices were grown on InAs substrates by molecular beam epitaxy. The samples were grown in a manner that allowed the nature of the interfacial bonds (either GaAs or In(As,Sb)-like) to be controlled). In some of the samples the bond type-related strain was accommodated by adjusting the Sb mole fraction to nearly lattice match the superlattice to the substrate regardless of bond configuration. High-resolution X-ray diffraction measurements and transmission electron microscopy images reveal that samples grown with In(As,Sb)-like bonds on top of the InAs layers exhibit superior structural quality. Samples with GaAs-like bonds at both interfaces are far inferior to the others. C1 USA, Res Lab, AMSRL SE EI, Adelphi, MD 20783 USA. RP Sarney, WL (reprint author), USA, Res Lab, AMSRL SE EI, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1350-2433 J9 IEE P-OPTOELECTRON JI IEE Proc.-Optoelectron. PD AUG PY 2003 VL 150 IS 4 BP 415 EP 419 DI 10.1049/ip-opt:20030408 PG 5 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA 744KN UT WOS:000186628700030 ER PT J AU Stokes, DW Forrest, RL Li, JH Moss, SC Nosho, BZ Bennett, BR Whitman, LJ Goldenberg, M AF Stokes, DW Forrest, RL Li, JH Moss, SC Nosho, BZ Bennett, BR Whitman, LJ Goldenberg, M TI X-ray diffraction analysis of lateral composition modulation in InAs/GaSb superlattices intended for infrared detector applications SO IEE PROCEEDINGS-OPTOELECTRONICS LA English DT Article; Proceedings Paper CT 5th International Conference on Mid-Infrared Optoelectronics Materials and Devices CY SEP 08-11, 2002 CL ANNAPOLIS, MD ID STRAINED-LAYER SUPERLATTICES; FREE SOLID FILMS; MORPHOLOGICAL INSTABILITY; STEP ENERGIES; MU-M; STABILITY; GROWTH; LASERS; HETEROSTRUCTURES; DEPENDENCE AB Lateral compositional modulation in a (InAs)(13)/(GaSb)(13) superlattice grown by molecular beam epitaxy for infrared detector applications has been investigated using high-resolution X-ray diffraction. X-ray diffraction reciprocal space maps exhibit distinct lateral satellite peaks about the vertical superlattice peaks; however, the pattern is tilted with respect to the (001) direction. This tilt is directly related to the stacking of the layers as revealed by cross-sectional scanning tunnelling microscopy (XSTM) images. XSTM shows the morphology of the structure to consist of InAs- and GaSb-rich regions with a modulation wavelength of similar to1200 Angstrom and a lateral composition wavelength of 554 3 A. The modulation only occurs along one in-plane direction, resulting in InAs 'nanowires' along the [1 (1) over bar0] direction, which are several microns long. The possible causes of the lateral composition modulation and its impact on device performance are discussed. C1 Univ Houston, Dept Phys, Houston, TX 77204 USA. USA, Res Lab, Malibu, CA 90265 USA. USN, Res Lab, Washington, DC 20375 USA. SFA Inc, Largo, MD 20774 USA. RP Stokes, DW (reprint author), Univ Houston, Dept Phys, Houston, TX 77204 USA. RI Bennett, Brian/A-8850-2008; Whitman, Lloyd/G-9320-2011 OI Bennett, Brian/0000-0002-2437-4213; Whitman, Lloyd/0000-0002-3117-1174 NR 31 TC 0 Z9 0 U1 1 U2 3 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1350-2433 J9 IEE P-OPTOELECTRON JI IEE Proc.-Optoelectron. PD AUG PY 2003 VL 150 IS 4 BP 420 EP 423 DI 10.1049/ip-opt:20030643 PG 4 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA 744KN UT WOS:000186628700031 ER PT J AU Brucker, GJ Basso, A Bechtel, E Gentner, E AF Brucker, GJ Basso, A Bechtel, E Gentner, E TI Locating radiation hot spots on the ground with a gamma-ray directional sensor SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article DE directional sensor; helicopter; hot spots; radiation ID IMAGING SOURCES; X-RADIATION AB This paper reports on an experimental investigation to determine the feasibility of locating radiation hot spots within an area of contamination on the ground that contains radionuclides. The detecting and locating sensor is carried in a helicopter that can rapidly scan large areas of contamination for hot spots. A scintillation type of gamma-ray directional sensor (GRDS) was used in this study. Previous work showed that a GRDS could detect and accurately locate stationary point and broad sources of gamma-rays or X-rays by rotating a GRDS in the field of radiation. In this present study, the sensor was stationary but the radiation source was moving pass the sensor. This technique simulated a helicopter flying over an area of contamination on the ground and scanning the area for hot spots with a sensor that is fixed in position on board the helicopter. The experimental approach generated data that established the operational limitations of the helicopter's speed, height, and the intensity of the hot spot relative to the GRDS's sensitivity. The results show that a GRDS sensor in a helicopter can locate cesium-137 hot spots on the ground. Hot spots with an activity of about 0.3 Ci can be located from a helicopter moving with a speed of 44.7 m/s at a height of 62.5 m. C1 USA, NBC Def Syst, RADIAC Project Off, Ft Monmouth, NJ 07703 USA. RP Brucker, GJ (reprint author), USA, NBC Def Syst, RADIAC Project Off, Ft Monmouth, NJ 07703 USA. NR 11 TC 2 Z9 2 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD AUG PY 2003 VL 50 IS 4 BP 1253 EP 1256 DI 10.1109/TNS.2003.814940 PN 2 PG 4 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA 712GV UT WOS:000184790700003 ER PT J AU Maharshi, A Tong, L Swami, A AF Maharshi, A Tong, L Swami, A TI Cross-layer designs of multichannel reservation MAC under Rayleigh fading SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE cross layer design; decision theory; medium access control; multichannel reservation; multiple access; Neyman-Pearson MAC design ID ACCESS WIRELESS NETWORKS; SENSE MULTIPLE-ACCESS; MULTIPACKET RECEPTION; RETRANSMISSION CONTROL; RADIO CHANNELS; SLOTTED ALOHA; MOBILE RADIO; CAPTURE; DIVERSITY; PROTOCOL AB We consider a reservation-based medium access control (MAC) scheme where users reserve data channels through a slotted-ALOHA procedure. The base station grants access to users in a Rayleigh fading environment using measurements at the physical layer and system information at the MAC layer. This paper has two contributions pertaining to simple reservation based medium access. First, we provide a Markov chain formulation to analyze the performance (throughput/channel utilization) of multichannel slotted system. Second, a Neyman-Pearson like MAC design optimized for performance is presented. This design can serve as a benchmark in evaluating the performance of other designs based on conventional physical layer detectors such as maximum a posteriori probability, maximum likelihood, and uniformly most powerful detectors. Results show that utilizing system information in addition to the physical layer measurements indeed leads to a gain in performance. We discuss the issue of further improving the performance in fading by means of multiple measurements and also comment on the delay/channel-utilization trade-off for the optimal MAC design. C1 Cornell Univ, Sch Elect Engn, Ithaca, NY 14853 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Maharshi, A (reprint author), Cornell Univ, Sch Elect Engn, Phillips Hall, Ithaca, NY 14853 USA. NR 22 TC 16 Z9 17 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD AUG PY 2003 VL 51 IS 8 BP 2054 EP 2067 DI 10.1109/TSP.2003.814465 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA 700AJ UT WOS:000184090200005 ER PT J AU Ariel, N Zvi, A Makarova, KS Chitlaru, T Elhanany, E Velan, B Cohen, S Friedlander, AM Shafferman, A AF Ariel, N Zvi, A Makarova, KS Chitlaru, T Elhanany, E Velan, B Cohen, S Friedlander, AM Shafferman, A TI Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens SO INFECTION AND IMMUNITY LA English DT Review ID GRAM-POSITIVE BACTERIA; FIBRONECTIN-BINDING PROTEIN; GROUP-A STREPTOCOCCUS; STAPHYLOCOCCUS-AUREUS; S-LAYER; REVERSE VACCINOLOGY; VIRULENCE FACTORS; CELL-SURFACE; MOLECULAR CHARACTERIZATION; LISTERIA-MONOCYTOGENES AB Bacillus anthracis (Ames strain) chromosome-derived open reading frames (ORFs), predicted to code for surface exposed or virulence related proteins, were selected as B. anthracis-specific vaccine candidates by a multistep computational screen of the entire draft chromosome sequence (February 2001 version, 460 contigs, The Institute for Genomic Research, Rockville, Md.). The selection procedure combined preliminary annotation (sequence similarity searches and domain assignments), prediction of cellular localization, taxonomical and functional screen and additional filtering criteria (size, number of paralogs). The reductive strategy, combined with manual curation, resulted in selection of 240 candidate ORFs encoding proteins with putative known function, as well as 280 proteins of unknown function. Proteomic analysis of two-dimensional gels of a B. anthracis membrane fraction, verified the expression of some gene products. Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry analyses allowed identification of 38 spots cross-reacting with sera from B. anthracis immunized animals. These spots were found to represent eight in vivo immunogens, comprising of EA1, Sap, and 6 proteins whose expression and immunogenicity was not reported before. Five of these 8 immunogens were preselected by the bioinformatic analysis (EA1, Sap, 2 novel SLH proteins and peroxiredoxin/AhpC), as vaccine candidates. This study demonstrates that a combination of the bioinformatic and proteomic strategies may be useful in promoting the development of next generation anthrax vaccine. C1 Israel Inst Biol Res, Dept Biochem & Mol Genet, IL-74100 Ness Ziona, Israel. Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Ariel, N (reprint author), Israel Inst Biol Res, Dept Biochem & Mol Genet, POB 19, IL-74100 Ness Ziona, Israel. NR 110 TC 78 Z9 87 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 2003 VL 71 IS 8 BP 4563 EP 4579 DI 10.1128/IAI.71.8.4563-4579.2003 PG 17 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 705JV UT WOS:000184392700040 PM 12874336 ER PT J AU Poggi, MM Gant, DA Sewchand, W Warlick, WB AF Poggi, MM Gant, DA Sewchand, W Warlick, WB TI Marker seed migration in prostate localization SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article; Proceedings Paper CT 44th Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology CY OCT 06-10, 2002 CL NEW ORLEANS, LOUISIANA SP Amer Soc Therapeut Radiol & Oncol DE prostate localization; marker seeds; prostate motion ID IMPLANTED RADIOPAQUE MARKERS; MOTION; RADIOTHERAPY; QUANTIFICATION; POSITION; THERAPY AB Purpose: Marker seed location was analyzed to test the hypothesis that there is no intraseed migration within the prostate, a premise fundamental to the technique of marker seed localization of this organ. Despite increasing interest in the use of implanted seeds as fiducial markers for gland location, there are few data available with which to evaluate the validity of this technique, particularly over the entire course of external beam radiation therapy. Methods and Materials: Between May 2001 and December 2001, after obtaining fully informed written consent, 9 patients with early stage prostate cancer were enrolled on an institutionally reviewed protocol. Patients had four to five marker seeds implanted into the prostate under transrectal ultrasound guidance before definitive radiotherapy. The porous gold seeds were each 1.2 X 2.0 mm in dimension. Seed locations from orthogonal radiographs based on the initial simulation and weekly orthogonal films were digitized using a CMS Focus planning system, thereby facilitating the determination of intraseed spacing. The digitization of the isocenter from each orthogonal pair of radiographs was used to determine digitizing error for seed localization. Pubic symphysis, bilateral femoral heads, and isocenter were also digitized and will be analyzed at a later date. Results: Overall, the average migration of all the seeds in the patients was 1.2 +/- 0.2 (SD) mm. The greatest average movement of any seed in any patient was 1.9 turn over the entire 7-week course of radiotherapy. The smallest average movement was 0.6 mm. The greatest change in intraseed spacing in any of the patients during the full course of therapy was 6.6 mm. One seed in 1 patient was lost at the start of the third week of therapy and censored from analysis. Digitizing error in seed localization was calculated to be 0.20 +/- 0.03 (SD) mm. Conclusions: As an aggregate, there is negligible seed migration within the prostate over the entire course of definitive radiotherapy. However, there are small, detectable movements in individual seed locations, perhaps resulting from topographic changes in the gland secondary to seed placement, anatomic changes in bladder and rectum, or treatment itself. With respect to seed migration, prostate marker seeds represent an accurate and reliable surrogate of gland location during a full course of radiotherapy. (C) 2003 Elsevier Inc. C1 Walter Reed Army Med Ctr, Dept Radiol, Radiat Oncol Serv, Washington, DC 20307 USA. RP Poggi, MM (reprint author), 5412 30th Pl NW, Washington, DC 20015 USA. NR 15 TC 82 Z9 82 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD AUG 1 PY 2003 VL 56 IS 5 BP 1248 EP 1251 DI 10.1016/S0360-3016(03)00328-6 PG 4 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 702ZW UT WOS:000184256000006 PM 12873668 ER PT J AU Wu, XY Ramesh, KT Wright, TW AF Wu, XY Ramesh, KT Wright, TW TI The effects of thermal softening and heat conduction on the dynamic growth of voids SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE ductile failure; dynamic; plasticity; instability ID ELASTIC-PLASTIC SOLIDS; CAVITATION INSTABILITIES; VISCOPLASTIC MATERIALS; SPALL STRENGTH; PORE-COLLAPSE; FRACTURE; ALUMINUM; MODEL AB This paper seeks to examine the dynamic growth of a single void in an elastic-plastic medium through analytical and numerical approaches. Particular attention is paid to the instability of void growth, and to the effects of inertia, thermal softening and heat conduction. A critical stress is known to exist for the unstable growth of voids. The dependence of this critical stress on material properties is examined, and this critical stress is demonstrated to correspond to the lower limit for the ductile spall strength in many materials. The effects of heat conduction on the dynamic growth of voids strongly depend on the time and length scales in the early stages of the dynamic void growth. (C) 2003 Elsevier Ltd. All rights reserved. C1 Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Ramesh, KT (reprint author), Johns Hopkins Univ, Dept Mech Engn, 122 Latrobe Hall,3400 N Charles St, Baltimore, MD 21218 USA. NR 26 TC 26 Z9 27 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD AUG PY 2003 VL 40 IS 17 BP 4461 EP 4478 DI 10.1016/S0020-7683(03)00214-2 PG 18 WC Mechanics SC Mechanics GA 700RP UT WOS:000184125200009 ER PT J AU Frazier, RM Stapleton, J Thaler, GT Abernathy, CR Pearton, SJ Rairigh, R Kelly, J Hebard, AF Nakarmi, ML Nam, KB Lin, JY Jiang, HX Zavada, JM Wilson, RG AF Frazier, RM Stapleton, J Thaler, GT Abernathy, CR Pearton, SJ Rairigh, R Kelly, J Hebard, AF Nakarmi, ML Nam, KB Lin, JY Jiang, HX Zavada, JM Wilson, RG TI Properties of Co-, Cr-, or Mn-implanted AIN SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DISTRIBUTED BRAGG REFLECTORS; BAND-EDGE PHOTOLUMINESCENCE; LIGHT-EMITTING-DIODES; QUANTUM-WELLS; THIN-FILMS; BULK ALN; FERROMAGNETISM; EMISSION; GROWTH; DEVICE AB AlN layers grown on Al2O3 substrates by metalorganic chemical vapor desposition were implanted with high doses (3 x 10(16) cm(-2), 250 keV) of Co+, Cr+, or Mn+. Band-edge photoluminescence intensity at similar to6 eV was significantly reduced by the implant process and was not restored by 950degreesC annealing. A peak was observed at 5.89 eV in all the implanted samples. Impurity transitions at 3.0 and 4.3 eV were observed both in implanted and unimplanted AlN. X-ray diffraction showed good crystal quality for the 950degreesC annealed implanted samples, with no ferromagnetic second phases detected. The Cr- and Co-implanted AlN showed hysteresis present at 300 K from magnetometry measurements, while the Mn-implanted samples showed clear loops up to similar to100 K. The coercive field was <250 Oe in all cases. (C) 2003 American Institute of Physics. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Phys, Gainesville, FL 32611 USA. Kansas State Univ, Dept Phys, Manhattan, KS 66506 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Pearton, SJ (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@use.ufl.edu RI Lin, Jingyu/A-7276-2011; Jiang, Hongxing/F-3635-2011 OI Lin, Jingyu/0000-0003-1705-2635; Jiang, Hongxing/0000-0001-9892-4292 NR 34 TC 42 Z9 44 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2003 VL 94 IS 3 BP 1592 EP 1596 DI 10.1063/1.1586987 PG 5 WC Physics, Applied SC Physics GA 705ND UT WOS:000184400400046 ER PT J AU Johnson, GR Holmquist, TJ Beissel, SR AF Johnson, GR Holmquist, TJ Beissel, SR TI Response of aluminum nitride (including a phase change) to large strains, high strain rates, and high pressures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SILICON-CARBIDE; MECHANICAL-BEHAVIOR; SHOCK RESPONSE; TRANSFORMATION; IMPACT AB This article contains a description of a computational constitutive model for brittle materials subjected to large strains, high strain rates, and high pressures. The focus of this model is to determine the response of aluminum nitride under high velocity impact conditions that produce large strains, high strain rates, and high pressures. The strength is expressed as a function of the pressure, strain rate, and accumulated damage; and it allows for strength of both intact and failed material. The pressure is primarily expressed as a function of the volumetric strain, but it also includes the effect of bulking for the failed material. For materials without a phase change this model is an extension of the previous Johnson-Holmquist models for brittle materials. The primary new feature of this model is the capability to include a phase change, and this is required for aluminum nitride. Computations are performed to illustrate the capabilities of the model, to compare computed results to experimental results, and to provide an understanding of the behavior of aluminum nitride under the conditions of high velocity impact. (C) 2003 American Institute of Physics. C1 Network Comp Serv Inc, Army High Performance Comp Res Ctr, Minneapolis, MN 55458 USA. RP Johnson, GR (reprint author), Network Comp Serv Inc, Army High Performance Comp Res Ctr, POB 581459, Minneapolis, MN 55458 USA. NR 23 TC 54 Z9 54 U1 2 U2 22 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2003 VL 94 IS 3 BP 1639 EP 1646 DI 10.1063/1.1589177 PG 8 WC Physics, Applied SC Physics GA 705ND UT WOS:000184400400051 ER PT J AU Zhao, PJ Woolard, DL Gelmont, BL Cui, HL AF Zhao, PJ Woolard, DL Gelmont, BL Cui, HL TI Creation and quenching of interference-induced emitter-quantum wells within double-barrier tunneling structures SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INTRINSIC BISTABILITY; WIGNER-FUNCTION; SIMULATION; TRANSPORT; OSCILLATIONS; HYSTERESIS; SYSTEMS; FORMULATION; DEVICES; ORIGIN AB The initial creation and subsequent quenching of the emitter quantum well within double-barrier resonant tunneling structures (RTSs) is the key process that explains the origin of the hysteresis and plateau-like structure of the I-V characteristics. This fundamental process, which evolves out of quantum-mechanical interference, defines the basic mechanism that can lead to intrinsic high-frequency oscillations. This article presents numerical results, derived from a coupled Wigner-Poisson model, that illustrate the underlying mechanisms responsible for the creation and disappearance of the emitter-quantum well. Additional theoretical results are also given that demonstrates how subband state coupling, between the emitter-quantum well (EQW) and the main-quantum well (MQW) defined by the double-barrier heterostructure, leads to the hysteresis and instability behavior. This article will reveal how the quantum interference that develops between the incident and reflected electron wave function (i.e., from the first barrier) leads to the formation of an emitter-quantum well. An analysis is also performed to define the effects of EQW-MQW subband coupling on the current-density verses voltage (I-V) characteristics and the overall I-V dependence on the initial charging states of the individual wells. In particular, this analysis is used to show how the EQW is formed and quenched and how it influences the time-dependent behavior of the structure when it is subject to forward- and backward-bias sweeps of the applied bias voltages. This article provides fundamental quantum-mechanical explanations for the complicated time-dependent processes within double-barrier RTSs and provides insight into the hysteresis and intrinsic oscillation behavior. (C) 2003 American Institute of Physics. C1 N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. Univ Virginia, Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. Stevens Inst Technol, Dept Phys & Engn Phys, Hoboken, NJ 07030 USA. RP Zhao, PJ (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. NR 29 TC 11 Z9 11 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD AUG 1 PY 2003 VL 94 IS 3 BP 1833 EP 1849 DI 10.1063/1.1587003 PG 17 WC Physics, Applied SC Physics GA 705ND UT WOS:000184400400081 ER PT J AU van Donk, SJ Huang, XW Skidmore, EL Anderson, AB Gebhart, DL Prehoda, VE Kellogg, EM AF van Donk, SJ Huang, XW Skidmore, EL Anderson, AB Gebhart, DL Prehoda, VE Kellogg, EM TI Wind erosion from military training lands in the Mojave Desert, California, USA SO JOURNAL OF ARID ENVIRONMENTS LA English DT Article DE BSNE sampler; Sensit; sediment discharge; saltation ID CRYPTOGAMIC SOIL CRUSTS; DISTURBANCE; PREDICTION; RECOVERY; PARK AB Military training activities reduce vegetation cover, disturb crusts, and degrade soil aggregates, making the land more vulnerable to wind erosion. The objective of this study was to quantify wind erosion rates for typical conditions at the Marine Corps Air Ground Combat Center, Twentynine Palms, CA, U.S.A. Five Big Spring Number Eight (BSNE) sampler stations were installed at each of five sites. Each BSNE station consisted of five BSNE samplers with the lowest sampler at 0.05 m and the highest sampler at 1.0 m above the soil surface. Once a month, sediment was collected from the samplers for analysis. Occurrence of saltating soil aggregates was recorded every hour using Sensits, one at each site. The site with the most erosion had a sediment discharge of 311 kg m(-1) over a period of 17 months. Other sites eroded much less because of significant rock cover or the presence of a crust. Hourly sediment discharge was estimated combining hourly Sensit count and monthly sediment discharge measured using BSNE samplers. More simultaneously measured data are needed to better characterize the relationship between these two and reconstruct a detailed time-series of wind erosion. This measured time-series can then be used for comparison with simulation results from process-based wind erosion models such as the Wind Erosion Prediction System (WEPS), once it has been adapted to the unique aspects of military lands. Published by Elsevier Science Ltd. C1 USDA ARS, Wind Erosion Res Unit, Manhattan, KS 66502 USA. USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. Tierra Data Syst, Escondido, CA USA. US Marine Corps, Marine Corps Air Ground Combat Ctr, Nat Res & Environm Affairs Off, Twentynine Palms, CA USA. RP van Donk, SJ (reprint author), USDA ARS, Wind Erosion Res Unit, 1515 Coll Ave, Manhattan, KS 66502 USA. NR 36 TC 22 Z9 22 U1 0 U2 9 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0140-1963 J9 J ARID ENVIRON JI J. Arid. Environ. PD AUG PY 2003 VL 54 IS 4 BP 687 EP 703 DI 10.1006/jare.2002.1085 PG 17 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 690YB UT WOS:000183577100005 ER PT J AU Kiang, JG McClain, DE Warke, VG Krishnan, S Tsokos, GC AF Kiang, JG McClain, DE Warke, VG Krishnan, S Tsokos, GC TI Constitutive NO synthase regulates the Na+/Ca2+ exchanger in human T cells: Role of Ca2+]i and tyrosine phosphorylation SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE Na+/Ca2+ exchanger; Ca2+; NO synthase; heat stress; lymphocytes; T cells; tyrosine phosphorylation; CD95; Fas ID NITRIC-OXIDE SYNTHASE; EPIDERMOID A-431 CELLS; CYTOSOLIC FREE CA2+; L-ARGININE; HEAT-SHOCK-PROTEIN-70 KDA; INOSITOL TRISPHOSPHATE; HEAT-SHOCK; T84 CELLS; EXPRESSION; INCREASES AB Form any types of cells, heat stress leads to an increase in intracellular free calcium concentration ([Ca2+](i)) that has been shown to trigger a wide variety of cellular responses. In T lymphocytes, for example, heat stress stimulates pathways that make them more susceptible to Fas/CD95-mediated apoptosis. Because of our interest in understanding more about the response of lymphocytes to various stressors, we used human peripheral and Jurkat T lymphocytes to investigate the effect of heat stress on calcium homeostasis. We found that peripheral and Jurkat T cells both exhibit cNOs activity but not iNOs activity. Heat stress increased NO production, which was inhibited by LNNA (a cNOs inhibitor) but not L-NIL (an iNOs inhibitor). Heat stress increased [Ca2+](i) in Jurkat T cells by decreasing the Km of the cell surface membrane Na+/Ca2+ exchanger for extracellular Ca2+. Heating also increased cNOs phosphorylation at tyrosine residues. In cells incubated with LNNA, heatstress promoted an increase in [Ca2+](i) and a decrease in [Na+](i) greater than in cells heated without LNNA, a larger decrease in K-m of the Na+/Ca2+ exchanger for extracellular Ca2+, and decreased phosphorylation of cNOs. Our results suggest that cNOs plays an important regulatory role after heat stress. Heating appears to increase the phosphorylation of cNOs that is complexed with the Na+/Ca2+ exchanger to decrease its activity. This process is related to increased expression of Fas/CD95 on the cell surface, which might explain the apoptotic diathesis of lymphocytes after heat stress. Published 2003 Wiley-Liss, Inc.dagger C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA. Armed Forces Radiobiol Res Inst, Appl Cellular Radiobiol Dept, Bethesda, MD 20889 USA. RP Kiang, JG (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, 503 Robert Grant Ave,Room 1N07, Silver Spring, MD 20910 USA. NR 42 TC 13 Z9 16 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD AUG 1 PY 2003 VL 89 IS 5 BP 1030 EP 1043 DI 10.1002/jcb.10564 PG 14 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 708EL UT WOS:000184554100016 PM 12874836 ER PT J AU Cerco, CF AF Cerco, CF TI Scientific versus engineering modeling SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Editorial Material C1 USA, Corps Engineers, Engn Waterways Expt Stn, CEWES ES Q, Vicksburg, MS 39180 USA. RP Cerco, CF (reprint author), USA, Corps Engineers, Engn Waterways Expt Stn, CEWES ES Q, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD AUG PY 2003 VL 129 IS 8 BP 681 EP 682 DI 10.1061/(ASCE)0733-9372(2003)129:8(681) PG 2 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 703QR UT WOS:000184292900001 ER PT J AU Markotic, A Hensley, L Geisbert, T Spik, K Schmaljohn, C AF Markotic, A Hensley, L Geisbert, T Spik, K Schmaljohn, C TI Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID RENAL SYNDROME HFRS; HEMORRHAGIC-FEVER; VIRUS-INFECTION; RECEPTOR; DISEASE; LINE; DNA AB Hantaviruses are maintained in nature in persistently infected rodents and can also persistently infect cultured mammalian cells, causing little or no cytopathology. An unexpected outcome of this study was the observation of cytopathic effects (CPE) in the hantavirus-infected human embryonic kidney cell line HEK293. It was confirmed that hantaviruses induce apoptosis in HEK293 cells, although apoptosis appeared mostly in uninfected, bystander cells and rarely in infected HEK293 cells. Although studies by others suggest that the nucleocapsid protein of Puumala virus interacts with the Fas-mediated apoptosis enhancer Daxx at the gene expression level, it was determined that members of the TNF receptor superfamily did not contribute to the apoptosis observed in infected HEK293 cells. The observation of CPE in HEK293 cells might lead to a better understanding of the mechanisms of persistence and pathogenesis in hantavirus infections. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. Inst Immunol, Dept Res & Dev, Zagreb, Croatia. RP Schmaljohn, C (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1301 Ditto Ave, Ft Detrick, MD 21702 USA. NR 26 TC 30 Z9 32 U1 0 U2 0 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD AUG PY 2003 VL 84 BP 2197 EP 2202 DI 10.1099/vir.0.19090-0 PN 8 PG 6 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 705TR UT WOS:000184411600029 PM 12867652 ER PT J AU Friedman, JF Kurtis, JD Mtalib, R Opollo, M Lanar, DE Duffy, PE AF Friedman, JF Kurtis, JD Mtalib, R Opollo, M Lanar, DE Duffy, PE TI Malaria is related to decreased nutritional status among male adolescents and adults in the setting of intense perennial transmission SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 50th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 11-15, 2001 CL ATLANTA, GEORGIA SP Amer Soc Trop Med & Hygiene ID TUMOR-NECROSIS-FACTOR; PRIMARY-SCHOOL CHILDREN; TREATED BED NETS; PLASMODIUM-FALCIPARUM; WESTERN KENYA; INFECTION; GROWTH; CACHEXIA; IMPACT; ANEMIA AB We studied the impact of Plasmodium falciparum on nutritional status in a longitudinal cohort of 147 young men in western Kenya, where malaria transmission is intense and perennial. All volunteers received treatment to eradicate parasitemia and then provided weekly blood smears during a 16-week transmission season. We measured body mass index (BMI), pubertal development, frequency and density of parasitemia, and tumor necrosis factor (TNF)-alpha production by peripheral blood mononuclear cells. During early puberty, mean parasite density had a strong negative effect on the natural increase in BMI. Among older individuals, TNF-alpha production in response to malarial antigen predicted a significantly lower BMI (P < .03), equal to 4.6 kg for a man of average height. Our data indicate that burden of parasitemia has a detrimental effect on the nutritional status of early adolescents and that malaria may continue to influence nutritional status among older adolescents and adults via host elaboration of proinflammatory cytokines. These effects of malaria may have pervasive health and socioeconomic consequences in areas where malaria is endemic. C1 Seattle Biomed Res Inst, Malaria Antigen Discovery Program, Seattle, WA 98109 USA. US Dept State, Inst Int Educ, Fulbright Fellowships, Washington, DC 20520 USA. Brown Univ, Sch Med, Int Hlth Inst, Providence, RI 02912 USA. Brown Univ, Sch Med, Dept Pediat, Providence, RI 02912 USA. Brown Univ, Sch Med, Dept Pathol & Lab Med, Providence, RI 02912 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. USA, Resp Med Unit, Kisumu, Kenya. Kenya Govt Med Res Ctr, Kisumu, Kenya. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, Malaria Antigen Discovery Program, 4 Nickerson St,Ste 200, Seattle, WA 98109 USA. RI Lanar, David/B-3560-2011; OI Friedman, Jennifer/0000-0001-5804-9921 FU NIAID NIH HHS [R01 AI43680, R01 AI52059, K23 AI52125, R01 AI48123] NR 44 TC 17 Z9 18 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2003 VL 188 IS 3 BP 449 EP 457 DI 10.1086/376596 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 704BB UT WOS:000184316900015 PM 12870128 ER PT J AU Qi, L Lee, BI Kim, JM Jang, JE Choe, JY AF Qi, L Lee, BI Kim, JM Jang, JE Choe, JY TI Synthesis and characterization of ZnS : Cu,Al phosphor prepared by a chemical solution method SO JOURNAL OF LUMINESCENCE LA English DT Article DE ZnS : Cu,Al; co-precipitation; particle size control ID ZINC-SULFIDE; PHOTOLUMINESCENCE; PRECIPITATION; MECHANISM; PARTICLES; FILMS AB A novel and simple synthesis route for the production of ZnS:Cu,Al sub-micron phosphor powder is reported. Both the host and activator cations were co-precipitated from an ethanol medium by mixing with a diluted ammonium sulfide solution. The co-precipitated ZnS:Cu,Al was in cubic zinc blende structure after an intermediate-temperature furnace annealing. Strong photoluminescent and cathodoluminescent (CL) emission were observed, which was attributed to the 3d(10)-3d(9)4s(1) radiative transition at those copper sites. At an accelerating voltage of 1 kV, the CL intensity of the co-precipitated ZnS:Cu,Al sample was recorded 94% of the commercial reference phosphor with the same composition made by high temperature solid-state-reaction method. The particle size of the co-precipitated phosphor powders was found to be controllable simply through adjusting the reactant concentrations. The particle size of the annealed samples was measured by dynamic light scattering, which showed a mean particle diameter between 200 and 700 nm depending on the co-precipitation conditions. (C) 2003 Elsevier Science B.V. All rights reserved. C1 Clemson Univ, Sch Mat Sci & Engn, Clemson, SC 29634 USA. Samsung Adv Inst Technol, Yongin 442743, Kyunggi Do, South Korea. USA, Res Lab, AMSRL, SE,EI, Adelphi, MD 20783 USA. RP Lee, BI (reprint author), Clemson Univ, Sch Mat Sci & Engn, Olin Hall,POB 340907, Clemson, SC 29634 USA. NR 17 TC 36 Z9 39 U1 1 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2313 J9 J LUMIN JI J. Lumines. PD AUG PY 2003 VL 104 IS 4 BP 261 EP 266 DI 10.1016/S0022-2313(03)00079-6 PG 6 WC Optics SC Optics GA 696QU UT WOS:000183898900003 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of bicyclo[1.1.0]butane SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; bicyclo[1.1.0]butane ID SMALL RING COMPOUNDS; ELECTRONIC-STRUCTURE; MICROWAVE SPECTRUM; CORRELATION-ENERGY; ORGANIC-MOLECULES; STRAINED BONDS; SIGMA-BONDS; BICYCLO<1.1.0>BUTANE; BICYCLOBUTANE; PHOTOCHEMISTRY AB The normal mode frequencies and corresponding vibrational assignments of bicyclo[1.1.0]butane are examined theoretically using the GAUSSIAN 98 set of quantum chemistry codes. All normal modes were successfully assigned to one of eight types of motion predicted by a group theoretical analysis (C-H stretch, C-C stretch, CH2 scissors, CH2 rock, CH2 wag, CH2 twist, C-H wag, and C-C-C bend) utilizing the C-2v symmetry of the molecule. Calculated infrared intensities and Raman activities are reported. The vibrational modes of the 1,3-d(2), 2,2,4,4-d(4) and d(6) forms of bicyclo[1.1.0]butane are calculated and compared against available experimental data. Selected molecular orbitals of bicyclo[1.1.0]butane are presented. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSSB, RRT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSSB, RRT,DP, Aberdeen Proving Ground, MD 21010 USA. NR 85 TC 4 Z9 4 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD AUG 1 PY 2003 VL 631 BP 157 EP 169 DI 10.1016/S0166-1280(03)00243-4 PG 13 WC Chemistry, Physical SC Chemistry GA 707PD UT WOS:000184518300018 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determinations of fumaronitrile SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; fumaronitrile; molecular orbitals ID ELECTRON-TRANSFER; SPECTRA; NITRILES; TETRACYANOETHYLENE; ISOMERIZATION; MALEONITRILE; COMPLEXES; OLEFINS; ELECTROHYDRODIMERIZATION; PHOTOCYCLOADDITION AB The normal mode frequencies and corresponding vibrational assignments of fumaronitrile are examined theoretically using the GAUSSIAN 98 set of quantum chemistry codes. Each of the vibrational modes was assigned to one of eight types of motion predicted by a group theoretical analysis (C-H stretch, CdropN stretch, C=C stretch, C-C stretch, C=C-C bend, C-CdropN bend, C-H wag, and C-C=C-C torsion) utilizing the C-2h symmetry of the molecule. Uniform scaling factors was derived for each type of motion. Predicted infrared and Raman intensities are reported. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSSB, RRT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSSB, RRT,DP, Aberdeen Proving Ground, MD 21010 USA. NR 55 TC 3 Z9 4 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD AUG 1 PY 2003 VL 631 BP 231 EP 240 DI 10.1016/S0166-1280(03)00254-9 PG 10 WC Chemistry, Physical SC Chemistry GA 707PD UT WOS:000184518300024 ER PT J AU Velez, MK Dorsett, C Ferguson, HW Hansen, K AF Velez, MK Dorsett, C Ferguson, HW Hansen, K TI Lemierre's syndrome: A case report SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Editorial Material ID FUSOBACTERIUM-NECROPHORUM INFECTIONS; ADHERENCE; STRAINS C1 USA, Dwight D Eisenhower Army Med Ctr, DENTAC, Dept Oral & Maxillofacial Surg, Ft Gordon, GA USA. USA, Dwight D Eisenhower Army Med Ctr, DENTAC, Dept Otolaryngol, Ft Gordon, GA USA. RP Velez, MK (reprint author), 3171 Glenbrooke Dr, Clarksville, TN 37043 USA. NR 19 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD AUG PY 2003 VL 61 IS 8 BP 968 EP 971 DI 10.1016/S0278-2391(03)00236-2 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 704TV UT WOS:000184357200020 PM 12905453 ER PT J AU Underwood, JH Troiano, E AF Underwood, JH Troiano, E TI Critical fracture processes in army cannons: A review SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID CRACKING AB Fast fracture in cannons can be well described using elastic-plastic fracture toughness, in combination with comparisons of cannon section size relative to the size required to maintain plane strain fracture. Fatigue fracture of cannon tubes is modeled from results of,full-size fatigue tests that simulate cannon firing. These tests are also the basis of fatigue-intensity-factor modeling of fatigue life, which incorporates material strength, initial crack size and Bauschinger-modified autofrettage residual stress into life predictions. Environment-assisted fracture in the thermally damaged near-bore region of fired cannons is shown to be controlled by hydrogen. High strength cannon steels are susceptible to hydrogen; cannon propellant gases provide the hydrogen; and the source of sustained tensile stress is the near-bore thermal damage and compressive yielding. A thermo-mechanical model predicts tensile residual stress of similar depth to that of observed hydrogen cracks. Coating fracture in the thermal-damage region offered cannons is characterized and modeled. The Evans/Hutchinson slip zone concept is extended to calculate in-situ coating fracture strength from observed crack spacing and hardness in the damaged region. C1 USA, Armament Res Dev & Engn Ctr, Benet Labs, Div Technol, Watervliet, NY 12189 USA. RP Underwood, JH (reprint author), USA, Armament Res Dev & Engn Ctr, Benet Labs, Div Technol, Watervliet, NY 12189 USA. NR 13 TC 16 Z9 19 U1 0 U2 6 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2003 VL 125 IS 3 BP 287 EP 292 DI 10.1115/1.1593075 PG 6 WC Engineering, Mechanical SC Engineering GA 720QQ UT WOS:000185271800010 ER PT J AU Underwood, JH Parker, AP Vigilante, GN Cote, PJ AF Underwood, JH Parker, AP Vigilante, GN Cote, PJ TI Thermal damage, cracking and rapid erosion of cannon bore coatings SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB Thermal damage observed at the bore of fired cannons has increased noticeably in the past decade, due to the use of higher combustion gas temperatures for improved cannon performance. Current authors and coworkers recently have described cannon firing damage and proposed new thermo-mechanical models to gain understanding of its causes, with emphasis on the severe damage that occurs in the steel beneath the chromium plating used to protect the cannon bore. Recent refinements in the models will be used here to characterize some additional damage observations in the area beneath the protective coating of fired cannons. Model results validated by microstructural observations give predictions of near-bore temperature and stress distributions and good agreement with observed depths of hydrogen cracking in the high strength steel substrate. Interest in damage and failure within a coating is also of concern for cannons, since coating failure leads to extremely rapid erosion of coating and substrate. The slip zone model of Evans and Hutchinson is adapted here to predict failure strength of cannon coatings based on serve crack spacing and microhardness of thermally damaged areas. Results are described for electroplated chromium coatings from fired cannons and for sputtered chromium and tantalum coatings with laser-heating damage to simulate firing. Coating mechanics analysis of fired and laser-heated samples provides an insitu measurement of coating failure strength, showing that sputtered chromium has more than twice the failure strength of electroplated chromium. An analysis of cyclic shear failure of a coating interface at an open crack shows a six-fold decrease in low cycle fatigue life compared to the life of a closed crack. Recommendations are given for preventing rapid coating failure and catastrophic erosion of fired cannon, with emphasis on methods to prevent deep, open cracks in coating and substrate. C1 USA, Armament Res Dev & Engn Ctr, Benet Labs, Div Technol, Watervliet, NY 12189 USA. Cranfield Univ, Royal Mil Coll Sci, Swindon SN6 8LA, Wilts, England. RP Underwood, JH (reprint author), USA, Armament Res Dev & Engn Ctr, Benet Labs, Div Technol, Watervliet, NY 12189 USA. NR 8 TC 26 Z9 30 U1 3 U2 10 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2003 VL 125 IS 3 BP 299 EP 304 DI 10.1115/1.1593077 PG 6 WC Engineering, Mechanical SC Engineering GA 720QQ UT WOS:000185271800012 ER PT J AU Parker, AP O'Hara, GP Underwood, JH AF Parker, AP O'Hara, GP Underwood, JH TI Hydraulic versus swage autofrettage and implications of the Bauschinger effect SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID TUBES AB A hybrid method is presented which permits calculation of residual stresses in a swage autofrettaged tube including Bauschinger effect. The results are generally supported by three types of available experimental evidence by comparing "equivalent" swage and hydraulic autofrettage tubes having the same level of overstrain. Radial slitting of the swaged tube is predicted to show a greater opening angle than its hydraulic equivalent. Fatigue lifetime of the swaged tube is predicted to be significantly higher than the hydraulic case. Re-pressurization of the equivalent tubes is predicted to produce initial re-yielding at the same pressure in both cases. Analysis of results shows that permanent strains in the swaged tube are expected to appear at a pressure level below that for the hydraulic tube. C1 Cranfield Univ, Royal Mil Coll Sci, Dept Syst Engn, Swindon SN8 6LA, Wilts, England. USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Parker, AP (reprint author), Cranfield Univ, Royal Mil Coll Sci, Dept Syst Engn, Swindon SN8 6LA, Wilts, England. NR 14 TC 14 Z9 16 U1 0 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2003 VL 125 IS 3 BP 309 EP 314 DI 10.1115/1.1593079 PG 6 WC Engineering, Mechanical SC Engineering GA 720QQ UT WOS:000185271800014 ER PT J AU Troiano, E Parker, AP Underwood, J Mossey, C AF Troiano, E Parker, AP Underwood, J Mossey, C TI Experimental data, numerical fit and fatigue life calculations relating to the Bauschinger effect in high strength armament steels SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article AB The uniaxial Bauschinger effect has been evaluated in several high strength steels being considered for armament application. The steels investigated include ASTM A 723 (1130 and 1330 MPa), PH 13-8 Mo stainless steel (1380 MPa), PH 13-8 Mo super tough stainless steel (1355 MPa), and HY 180 (1180MPa). Tests were conducted at plastic strains up to 3.5%. Results of testing show a progressive decrease in Bauschinger effect up to plastic strains of approximately 1% (for all materials investigated), after which there is little further decrease in the Bauschinger effect. Several key features were discovered during testing. First, all of the materials tested exhibited a changing modulus, where the elastic modulus on unloading after tensile plastic straining is consistently lower than that observed in the original loading of the specimens. The amount of modulus reduction is dependent upon the material tested, and larger reductions are observed with increasing amounts after tensile plastic strain. Prior work by Milligan reported Bauschinger effect factor beta for a modified 4340 steel (old vintage A723 steel), which compares well with the present work. However his results failed to mention any observations about a modulus reduction. The second observation was the expected strength reduction where a reduced compressive strength is observed as a result of prior tensile plastic straining. Numerical curve fits used to calculate residual stresses, which take into account both the modulus reduction and strength reduction are presented for all materials. Fatigue life calculations, utilizing the numerical curve fits, show good agreement with full size A723 laboratory fatigue test results. C1 USA, Armament Res Dev & Engn Ctr, Benet Labs, Div Technol, Watervliet, NY 12189 USA. Cranfield Univ, Royal Mil Coll Sci, Dept Syst Engn, Swindon SN6 8LA, Wilts, England. RP Troiano, E (reprint author), USA, Armament Res Dev & Engn Ctr, Benet Labs, Div Technol, Watervliet, NY 12189 USA. NR 10 TC 33 Z9 33 U1 0 U2 2 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2003 VL 125 IS 3 BP 330 EP 334 DI 10.1115/1.1593072 PG 5 WC Engineering, Mechanical SC Engineering GA 720QQ UT WOS:000185271800018 ER PT J AU Cote, PJ Lee, SL Todaro, ME Kendall, G AF Cote, PJ Lee, SL Todaro, ME Kendall, G TI Application of laser pulse heating to simulate thermomechanical damage at gun bore surfaces SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT Gun Tubes 2002 Conference CY SEP 15-18, 2002 CL KEBLE COLL, OXFORD, ENGLAND HO KEBLE COLL ID COATINGS; EROSION AB Laser pulse heating (LPH) experiments were performed to provide insights into the thermomechanical damage effects that occur at the surface of coated and uncoated gun steel under cyclic, rapid heating and cooling. These effects include generation of a heat-affected zone (HAZ), severe plastic deformation, crack blunting, cavitation, fracture initiation, and generation of residual stresses. In addition, several of the deformation effects observed in the HAZ indicate superplasticity. The results are compared with data from surfaces exposed to several different firing conditions to provide a basis for analyzing the specific role of the various degradation mechanisms. Supporting information is provided from x-ray diffraction measurement of residual stresses in the steel heat-affected zones produced in a firing environment. The measured compressive stresses are explained using dilatometry data and are shown to be consistent with the observed damage processes. C1 USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12184 USA. RP Cote, PJ (reprint author), USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12184 USA. NR 14 TC 4 Z9 5 U1 1 U2 5 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD AUG PY 2003 VL 125 IS 3 BP 335 EP 341 DI 10.1115/1.1593697 PG 7 WC Engineering, Mechanical SC Engineering GA 720QQ UT WOS:000185271800019 ER PT J AU Hook, GL Kimm, G Betsinger, G Savage, PB Swift, A Logan, T Smith, PA AF Hook, GL Kimm, G Betsinger, G Savage, PB Swift, A Logan, T Smith, PA TI Solid phase microextraction sampling and gas chromatography/mass spectrometry for field detection of the chemical warfare agent O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX) SO JOURNAL OF SEPARATION SCIENCE LA English DT Article DE VX; solid phase microextraction; field analysis; gas chromatography; mass spectrometry ID WATER AB A rapid detection method for the chemical warfare nerve agent VX was developed using SPME and gas chromatography/mass spectrometry (GC/MS). Five commercially available SPME fiber coatings were evaluated to determine the optimal fiber coating and conditions for extraction. The use of silanized vials was found to be necessary to limit interaction of the basic tertiary amine component of VX with the acidic silanols present in standard glass vials. The polydimethylsiloxane (PDMS) fiber was ultimately selected for completion of this work with extractions being performed at 50degreesC. Clothing material was spiked in the laboratory with 1 muL of neat VX, placed in a sealed vial, and taken into the field for SPME sampling, using optimized conditions studied. GC/MS analysis was also completed in the field using van-mounted instrumentation. With sampling and analysis completed in less than 20.0 minutes, detection of VX contamination was relatively rapid, especially considering the quality of the resulting data. The use of SPME also provides increased safety for the field analysis of VX since it does not require the handling of solvents for sample preparation and samples are not handled directly by the analyst. C1 Uniformed Serv Univ Hlth Sci, PMB Dept, Bethesda, MD 20814 USA. USA, Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. US Marine Corps Chem Biol Incident Response Force, Indian Head, MD USA. Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA. US Army Med Res, Inst Chem Dis, Edgewood, MD USA. RP Smith, PA (reprint author), Uniformed Serv Univ Hlth Sci, PMB Dept, A-1044,4301 Jones Bldg Rd, Bethesda, MD 20814 USA. EM psmith@usuhs.mil RI Smith, Philip/A-6835-2009 OI Smith, Philip/0000-0003-3787-9111 NR 21 TC 30 Z9 30 U1 4 U2 36 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1615-9306 J9 J SEP SCI JI J. Sep. Sci. PD AUG PY 2003 VL 26 IS 12-13 BP 1091 EP 1096 DI 10.1002/jssc.200301561 PG 6 WC Chemistry, Analytical SC Chemistry GA 718TW UT WOS:000185163400002 ER PT J AU Zhang, SS Xu, K Jow, TR AF Zhang, SS Xu, K Jow, TR TI Alkaline composite film as a separator for rechargeable lithium batteries SO JOURNAL OF SOLID STATE ELECTROCHEMISTRY LA English DT Article DE composite film; high-rate performance; ionic conductivity; lithium-ion battery; separator ID LI-ION CELLS; ELECTROLYTES; TEMPERATURE; PERFORMANCE; CARBONATE AB We report a new type of separator film for application in rechargeable lithium and lithium-ion batteries. The films are made of mainly alkaline calcium carbonate (CaCO3) and a small amount of polymer binder. Owing to porosity and capillarity, the composite films show excellent wettability with non-aqueous liquid electrolytes. Typically, the composite films composed of CaCO3 and Teflon and wetted with 1 M LiPF6 dissolved in a solvent mixture of ethylene carbonate (EC) and ethyl methyl carbonate (EMC) (30:70 wt%) exhibit an ionic conductivity as high as 2.5-4 mS/cm at 20degreesC, in a comparable range with that (3.4 mS/cm) of the commercial Celgard membrane. In the batteries, the composite film not only serves as a physical separator but also neutralizes acidic products, such as HF formed by LiPF6 hydrolysis, as well as those formed by solvent oxidative decomposition. A Li/LiMn2O4 test cell was employed to examine the electrochemical compatibility of the composite film. We observed that the composite film cell showed an improved cycling performance since the alkaline CaCO3 neutralizes the acidic products, which otherwise promote dissolution of the electrode active materials. More importantly, the composite film cell displayed a superior performance on high-rate cycling, which was probably the result of the less resistive interface formed between the electrode and the composite film. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 16 TC 14 Z9 15 U1 3 U2 20 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 1432-8488 J9 J SOLID STATE ELECTR JI J. Solid State Electrochem. PD AUG PY 2003 VL 7 IS 8 BP 492 EP 496 DI 10.1007/s10008-003-0375-y PG 5 WC Electrochemistry SC Electrochemistry GA 719KJ UT WOS:000185202000007 ER PT J AU Tufts, JB Frank, T AF Tufts, JB Frank, T TI Speech production in noise with and without hearing protection SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Academy-of-Audiology CY APR, 2002 CL PHILADELPHIA, PENNSYLVANIA SP Amer Acad Audio ID EAR PROTECTORS; AMBIENT NOISE; INTELLIGIBILITY; COMMUNICATION; DISCRIMINATION AB People working in noisy environments often complain of difficulty communicating when they wear hearing protection. It was hypothesized that part of the workers' communication difficulties stem from changes in speech production that occur when hearing protectors are worn. To address this possibility, overall and one-third-octave-band SPL measurements were obtained for 16 men and 16 women as they produced connected speech while wearing foam, flange, or no earplugs (open ears) in quiet and in pink noise at 60, 70, 80, 90, and 100 dB SPL. The attenuation and the occlusion effect produced by the earplugs were measured. The Speech Intelligibility Index (SII) was also calculated for each condition. The talkers produced lower overall speech levels, speech-to-noise ratios, and SII values, and less high-frequency speech energy, when they wore earplugs compared with the open-car condition. Small differences in the speech measures between the talkers wearing foam and flange earplugs were observed. Overall, the results of the study indicate that talkers wearing earplugs (and consequently their listeners) are at a disadvantage when communicating in noise. (C) 2003 Acoustical Society of America. C1 Penn State Univ, Dept Commun Disorders, University Pk, PA 16802 USA. RP Tufts, JB (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. FU ODCDC CDC HHS [U60/CCU315855-02] NR 38 TC 10 Z9 12 U1 0 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 2003 VL 114 IS 2 BP 1069 EP 1080 DI 10.1121/1.1592165 PG 12 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 709RE UT WOS:000184637500046 PM 12942985 ER PT J AU Banez, LL Prasanna, P Sun, L Ali, A Zou, ZQ Adam, BL McLeod, DG Moul, JW Srivastava, S AF Banez, LL Prasanna, P Sun, L Ali, A Zou, ZQ Adam, BL McLeod, DG Moul, JW Srivastava, S TI Diagnostic potential of serum proteomic patterns in prostate cancer SO JOURNAL OF UROLOGY LA English DT Article DE prostate; proteomics; prostatic neoplasms; spectrometry; mass; matrix-assisted laser desorption-ionization; proteins ID MASS-SPECTROMETRY; IDENTIFICATION; PROFILES; BENIGN AB Purpose: The serum prostate specific antigen test has been widely used in the last decade as an effective screening tool for prostate cancer (CaP). However, the high false-positive rate of the serum prostate specific antigen test necessitates the development of more accurate diagnostic and prognostic biomarkers for CaP. Promising diagnostic potential of serum protein patterns detected by surface enhanced laser desorption/ionization time of flight mass spectrometry for CaP has recently been reported. Independent evaluation of this new technology is warranted to realize its translational utility. We determined whether serum protein profiling by surface enhanced laser desorption/ionization time of flight mass spectrometry and a decision tree algorithm classification system could accurately discriminate between patients with CaP and unaffected individuals. Materials and Methods: Proteomic spectra of crude serum were generated using the Ciphergen ProteinChip System and pattern detection was performed using Biomarker Patterns Software (Ciphergen Biosystems, Inc., Fremont, California). A total of 106 patients with CaP and 56 controls were randomly allocated to a training set and a test set. The training set, which consisted of 44 patients with cancer and 30 controls, was used to build a decision tree algorithm. The test set, which consisted of 62 patients with cancer and 26 controls, was used in blinded fashion to validate the decision tree. Results: Accuracy of classification using the test set was 67% and 42% for the weak cation exchange array and the copper metal affinity capture array, respectively. Combined spectral data from the weak cation exchange and copper metal affinity capture arrays generated an algorithm that achieved 85% sensitivity and 85% specificity for the detection of CaP. Conclusions: These preliminary findings support recent observations that complex protein profiles have promising potential for the early detection of CaP and warrant future studies with streamlined technology. Furthermore, the combined effect of using 2 array types can greatly enhance the ability of protein profile patterns, suggesting the potential usefulness of alternative approaches to evaluate this new emerging technology. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. Eastern Virginia Med Sch, Dept Microbiol & Mol Cell Biol, Norfolk, VA 23501 USA. Walter Reed Army Med Ctr, Serv Urol, Washington, DC 20307 USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. NR 19 TC 96 Z9 111 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 2003 VL 170 IS 2 BP 442 EP 446 DI 10.1097/01.ju.0000069431.95404.56 PN 1 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 700WL UT WOS:000184134100022 PM 12853795 ER PT J AU Baughman, SM Morey, AF Van Geertruyden, PH Radvany, MG Benson, AE Foley, JP AF Baughman, SM Morey, AF Van Geertruyden, PH Radvany, MG Benson, AE Foley, JP TI Percutaneous transrenal application of fibrin sealant for refractory urinary leak after gunshot wound SO JOURNAL OF UROLOGY LA English DT Article DE fibrin tissue adhesive; ascites; wounds; gunshot; kidney ID GLUE; MANAGEMENT C1 Brooke Army Med Ctr, Serv Urol, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Intervent Radiol Serv, Ft Sam Houston, TX 78234 USA. RP Baughman, SM (reprint author), Brooke Army Med Ctr, Serv Urol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 3 TC 13 Z9 14 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 2003 VL 170 IS 2 BP 522 EP 523 DI 10.1097/01.ju.0000074976.94470.11 PN 1 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA 700WL UT WOS:000184134100044 PM 12853817 ER PT J AU Starnes, BW O'Donnell, SD Gillespie, DL Goff, JM Rosa, P Parker, MV Chang, A AF Starnes, BW O'Donnell, SD Gillespie, DL Goff, JM Rosa, P Parker, MV Chang, A TI Percutaneous arterial closure in peripheral vascular disease: A prospective randomized evaluation of the Pcrclose device SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 16th Annual Meeting of the Eastern-Vascular-Society CY MAY 02-05, 2002 CL BOSTON, MASSACHUSETTS SP Eastern Vasc Soc ID SUTURE-MEDIATED CLOSURE; PUNCTURE SITES; ACCESS SITES; COMPLICATIONS; CATHETERIZATION; MANAGEMENT; EXPERIENCE; DISCHARGE AB Background. Patients with peripheral vascular disease have been excluded from initial studies of percutaneous; suture-mediated closure devices (SMCD) despite representing a significant proportion of those requiring endovascular intervention. We sought to determine whether these devices could be safely used in patients with peripheral vascular disease. Methods: Patients were stratified into two groups and five subgroups on the basis of indication for arteriography, and they were prospectively randomized at the end of the procedure to receive either the SMCD or manual compression. Ankle-brachial index was determined and duplex ultrasound scanning of the accessed femoral artery was performed, before and after the procedure. Ultrasound data included peak systolic velocity, minimum intraluminal vessel diameter, and presence or absence of calcified plaque. Time to hemostasis, ambulation, and discharge were recorded, and major or minor complications were noted. Results. Of 102 patients included in the study, 52 patients were randomized to receive the SMCD. There was no difference in ankle-brachial index, minimum intraluminal vessel diameter, or peak systolic velocity in the accessed vessel after closure with SMCD or manual compression. Time to hemostasis, ambulation, and discharge was significantly less in the SMCD group (P = .001). Presence of calcified plaque was not associated with complications (P = .146). In the SMCD group, hemostasis was achieved with 49 of 52 devices (94.2%). There were six complications (5.9%), two of which were major and required operative intervention. All complications were hemorrhagic and not occlusive. There was no difference in overall complication rate between SMCD (7.7%) and manual compression (4.0%) groups (P = .678). No infection was noted in any of the 102 patients. Conclusions. Suture-mediated percutaneous arterial closure can be safely performed in patients with peripheral vascular disease, even in the presence of calcified plaque. This closure technique enables shorter time to hemostasis, ambulation, and hospital discharge. There are observed differences in minor, but not major, complication rates for MC versus percutaneous arterial closure in patients with peripheral vascular disease, but these differences did not achieve statistical significance in this small series. C1 Walter Reed Army Med Ctr, Peripheral Vasc Surg Clin W64, Vasc Surg Serv, Washington, DC USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Starnes, BW (reprint author), Walter Reed Army Med Ctr, Peripheral Vasc Surg Clin W64, Vasc Surg Serv, 6400 Georgia Ave NW, Washington, DC USA. NR 13 TC 34 Z9 36 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD AUG PY 2003 VL 38 IS 2 BP 263 EP 271 DI 10.1016/S0741-5214(03)00291-X PG 9 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 705RR UT WOS:000184409000009 PM 12891107 ER PT J AU Flournoy, WS Wohl, JS Albrecht-Schmitt, TJ Schwartz, DD AF Flournoy, WS Wohl, JS Albrecht-Schmitt, TJ Schwartz, DD TI Pharmacologic identification of putative D-1 dopamine receptors in feline kidneys SO JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS LA English DT Article ID ANESTHETIZED CAT; RAT-KIDNEY; AUTORADIOGRAPHIC LOCALIZATION; INDUCED DIURESIS; INHIBITION; FENOLDOPAM; MEMBRANES; DOGS; HYPERTENSION; STIMULATION AB The presence of dopamine (DA) receptors in feline kidneys is a matter of contention. Radioligand binding and Western blotting studies were employed to determine whether DA receptors are present in feline kidneys. The pharmacologic profile of the selective D-1 -receptor antagonist [(3) H]-SCH 23390 was studied in renal cortical membrane preparations from cats by conducting saturation binding isotherm and competitive binding experiments. [(3) H]-SCH 23390 bound to feline renal cortical membranes in a manner consistent with labeling of a D-1 -like receptor. The binding profile revealed a single site D-1 -like or D-1 receptor in the feline renal cortex with a K (d) = 7.8 +/- 1.0 nmol/L and B (max) = 76.5 +/- 19.5 fmol/mg. Competitive binding studies for [(3) H]-SCH 23390 against unlabeled agonists yielded the following K (i) values and rank order of competition: SKF38393 (K (i) = 0.47 +/- 0.26 mu m) > fenoldopam (K (i) = 3.12 +/- 1.1 mu m) > DA (K (i) = 933.1 +/- 1.6 mu m). Competitive binding studies for [(3) H]-SCH-23390 against unlabeled antagonists yielded the following rank order of competition: SCH 23390 (K (i) = 1.97 +/- 0.81 mu m) > spiperone (K (i) = 3.79 +/- 0.79) > metoclopramide (K (i) = 4.26 +/- 2.4 mu m). Western blot analysis with anti-DA D-1 receptor antibodies detected a single band with M (r) of 74 kDa corresponding to a D-1 DA receptor. These results suggest that a putative D-1 -like or D-1 receptor exists in feline kidneys different from those previously identified in rat, dog or human kidneys. C1 Auburn Univ, Coll Vet Med, Dept Clin Sci, Auburn, AL 36849 USA. Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. RP Wohl, JS (reprint author), Auburn Univ, Coll Vet Med, Dept Clin Sci, Auburn, AL 36849 USA. NR 63 TC 11 Z9 11 U1 1 U2 5 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 0140-7783 J9 J VET PHARMACOL THER JI J. Vet. Pharmacol. Ther. PD AUG PY 2003 VL 26 IS 4 BP 283 EP 290 DI 10.1046/j.1365-2885.2003.00494.x PG 8 WC Pharmacology & Pharmacy; Veterinary Sciences SC Pharmacology & Pharmacy; Veterinary Sciences GA 704HJ UT WOS:000184333700008 PM 12887611 ER PT J AU Polonis, VR de Souza, MS Darden, JM Chantakulkij, S Chuenchitra, T Nitayaphan, S Brown, AE Robb, ML Birx, DL AF Polonis, VR de Souza, MS Darden, JM Chantakulkij, S Chuenchitra, T Nitayaphan, S Brown, AE Robb, ML Birx, DL TI Human immunodeficiency virus type 1 primary isolate neutralization resistance is associated with the syncytium-inducing phenotype and lower CD4 cell counts in subtype CRF01_AE-infected patients SO JOURNAL OF VIROLOGY LA English DT Article ID ANTIBODY-MEDIATED NEUTRALIZATION; CORECEPTOR USAGE; VACCINE DEVELOPMENT; HIV TYPE-1; GENETIC DIVERSITY; PRIMARY INFECTION; AIDS VACCINES; V3 LOOP; CLADE-B; SENSITIVITY AB A number of human immunodeficiency virus type 1 (HIV-1) non-B-subtype products have been developed for present or future vaccine trials; in Thailand, several studies using subtype B and/or CRF01_AE vaccines have been conducted. To better characterize the biologic properties of these subtypes, 70 HIV-1 subtype B and E isolates were phenotyped as syncytium-inducing (SI) or non-syncytium-inducing (NSI) isolates and assessed for sensitivity to neutralizing antibody (NAb). A significantly higher number of NSI subtype E viruses were neutralization sensitive than SI subtype E viruses (P = 0.009), while no association between viral phenotype and sensitivity to NAb was observed for subtype B (P = 0.856), suggesting a difference in the neutralization patterns of subtypes B and E. Strikingly, concurrent CD4 T-cell numbers were significantly lower for subtype E-infected patients whose isolates were more resistant to NAb, both for the overall study group (P < 0.001) as well as for the 22 patients with NSI isolates (P = 0.013). Characterization of the evolution of biologic properties of both B and non-B HIV-1 subtypes will provide a clearer understanding of the repertoire of antibodies that must be elicited for a vaccine to be effective against all phenotypes and subtypes. C1 Henry M Jackson Fdn, Rockville, MD 20850 USA. Walter Reed Army Inst Res, Rockville, MD 20850 USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Mahidol Univ, Siriraj Hosp, Bangkok 10700, Thailand. RP Polonis, VR (reprint author), Henry M Jackson Fdn, Suite 200,13 Taft Ct, Rockville, MD 20850 USA. NR 49 TC 10 Z9 11 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD AUG PY 2003 VL 77 IS 15 BP 8570 EP 8576 DI 10.1128/JVI.77.15.8570-8576.2003 PG 7 WC Virology SC Virology GA 702FP UT WOS:000184214300042 PM 12857927 ER PT J AU Vasconcelos, D Barnewall, R Babin, M Hunt, R Estep, J Nielsen, C Carnes, R Carney, J AF Vasconcelos, D Barnewall, R Babin, M Hunt, R Estep, J Nielsen, C Carnes, R Carney, J TI Pathology of inhalation anthrax in cynomoigus monkeys (Macaca fascicularis) SO LABORATORY INVESTIGATION LA English DT Article AB Anthrax is considered a serious biowarfare and bioterrorism threat because of its high lethality, especially by the inhalation route. Rhesus macaques (Macaca mulatta) are the most commonly used nonhuman primate model of human inhalation anthrax exposure. The nonavailability of rhesus macaques necessitated development of an alternate model for vaccine testing and immunologic studies. This report describes the median lethal dose (LD50) and pathology of inhalation anthrax in cynomolgus macaques (Macaca fascicularis). Gross and microscopic tissue changes were reviewed in 14 cynomolgus monkeys that died or were killed after aerosol exposure of spores of Bacillus anthracis (Ames strain). The LD50 and 95% confidence intervals were 61,800 (34,000 to 110,000) colony-forming units. The most common gross lesions were mild splenomegaly, lymph node enlargement, and hemorrhages in various organs, particularly involving the meninges and the lungs. Mediastinitis, manifested as hemorrhage or edema, affected 29% of the monkeys. Microscopically, lymphocytolysis occurred in the intrathoracic lymph nodes and spleens of all animals, and was particularly severe in the spleen and in germinal centers of lymph nodes. Hemorrhages were common in lungs, bronchial lymph nodes, meninges, gastrointestinal tract, and mediastinum. These results demonstrate that the Ames strain of B. anthracis is lethal by the inhalation route in the cynomolgus macaque. The LD50 of the Ames strain of B. anthracis was within the expected experimental range of previously reported values in the rhesus monkey in an aerosol challenge. The gross and microscopic pathology of inhalation anthrax in the cynomolgus monkey is remarkably similar to that reported in rhesus monkeys and humans. The results of this study are important for the establishment of an alternative nonhuman primate model for evaluation of medical countermeasures against inhalational anthrax. C1 Toxicol Battelle Columbus, Columbus, OH 43201 USA. Def Adv Res Projects Agcy, Def Sci Off, Arlington, VA USA. USA, Med Res Inst Infect Dis, Off Prod Dev & Regulatory Affairs, Ft Detrick, MD 21702 USA. Biosci Int Inc, San Antonio, TX USA. RP Vasconcelos, D (reprint author), Toxicol Battelle Columbus, 505 King Ave, Columbus, OH 43201 USA. NR 7 TC 92 Z9 96 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD AUG PY 2003 VL 83 IS 8 BP 1201 EP 1209 DI 10.1097/01.LAB.0000080599.43791.01 PG 9 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA 713ZF UT WOS:000184887300011 PM 12920249 ER PT J AU Minyard, CM AF Minyard, CM TI Encyclopedia of American military history. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Blountstown, FL USA. RP Minyard, CM (reprint author), USA, Blountstown, FL USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 2003 VL 128 IS 13 BP 70 EP 70 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 710VG UT WOS:000184703100035 ER PT J AU Minyard, CM AF Minyard, CM TI Ripples of battle: How wars of the past still determine how we fight, how we live, and how we think. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Blountstown, FL 32424 USA. RP Minyard, CM (reprint author), USA, Blountstown, FL 32424 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 2003 VL 128 IS 13 BP 100 EP 101 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 710VG UT WOS:000184703100178 ER PT J AU Burgess, EB AF Burgess, EB TI The last ridge: The Odyssey of the 10th mountain division in World War II. SO LIBRARY JOURNAL LA English DT Book Review C1 COmbined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), COmbined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 2003 VL 128 IS 13 BP 101 EP 101 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 710VG UT WOS:000184703100180 ER PT J AU Wolfenstine, J AF Wolfenstine, J TI A high ratio of the testing temperature to the melting temperature: a necessary but not sufficient condition for an alloy anode to exhibit low capacity fade SO MATERIALS LETTERS LA English DT Article DE capacity fade; alloy; anode; brittle; diffusion ID LITHIUM-ION BATTERIES; MEASURING FRACTURE-TOUGHNESS; INDENTATION TECHNIQUES; NEGATIVE ELECTRODES; TIN; MICROCRACKING; BEHAVIOR; SILICON; SYSTEM; SOLIDS AB A CaLi2 alloy with micron-sized particles exhibited low specific capacity and rapid capacity fade. These results can be correlated with its low fracture toughness (K-IC approximate to 1 MPa m(1/2)). A high ratio of the testing temperature to the melting temperature (>0.4) is a necessary but not sufficient condition for an anode material to exhibit low capacity fade. The microstructure must also be considered. Published by Elsevier Science B.V. C1 USA, Res Lab, AMSRL SE DC, Adelphi, MD 20783 USA. RP Wolfenstine, J (reprint author), USA, Res Lab, AMSRL SE DC, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 33 TC 7 Z9 7 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X J9 MATER LETT JI Mater. Lett. PD AUG PY 2003 VL 57 IS 24-25 BP 3983 EP 3986 DI 10.1016/S0167-577X(03)00251-9 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 713FR UT WOS:000184846900048 ER PT J AU Riddle, JR Brown, M Smith, T Ritchie, C Brix, KA Romano, J AF Riddle, JR Brown, M Smith, T Ritchie, C Brix, KA Romano, J TI Chemical warfare and the Gulf War: A review of the impact on Gulf veterans' health SO MILITARY MEDICINE LA English DT Review ID POSTTRAUMATIC-STRESS-DISORDER; SELF-REPORTED EXPOSURES; GAS MASK PHOBIA; POSTWAR HOSPITALIZATION EXPERIENCE; COMPREHENSIVE CLINICAL-EVALUATION; CHRONIC MULTISYMPTOM ILLNESS; POPULATION-BASED SURVEY; OPERATION DESERT-STORM; TOKYO SUBWAY; US VETERANS AB It is unlikely that Gulf War veterans are suffering chronic effects from illnesses caused by chemical warfare nerve agent exposure. Extensive investigation and review by several expert panels have determined that no evidence exists that chemical warfare nerve agents were used during the Gulf War. At no time before, during, or after the war was there confirmation of symptoms among anyone, military or civilian, caused by chemical warfare nerve agent exposure. However, studies of Gulf War veterans have found belief that chemical weapons were used, significantly associated with both severe and mild-moderate illnesses. The psychological impact of a chemical warfare attack, either actual or perceived, can result in immediate and long-term health consequences. The deployment or war-related health impact from life-threatening experiences of the Gulf War, including the perceived exposure to chemical warfare agents, should be considered as an important cause of morbidity among Gulf War veterans. C1 The Pentagon, Hlth Affairs, Off Assistant Secretary Def, Washington, DC USA. Dept Vet Affairs, Washington, DC USA. USN, Hlth Res Ctr, San Diego, CA 92152 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Riddle, JR (reprint author), USAF, BSC, Skyline 6,Suite 682,5109 Leesburg Pike, Falls Church, VA 22041 USA. NR 158 TC 24 Z9 24 U1 1 U2 5 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2003 VL 168 IS 8 BP 606 EP 613 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 743AN UT WOS:000186550400005 PM 12943034 ER PT J AU Kemper, JA Donahue, DA Harris, JS AF Kemper, JA Donahue, DA Harris, JS TI The health assessment longitudinal file imperative: Foundation for improving the health of the force SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT DoD Population Health and Health Promotion Conference CY AUG 13, 2002 CL BALTIMORE, MARYLAND AB A smaller active duty force and an increased operational tempo have made the Reserve components (RC) essential elements in the accomplishment of the mission of the U.S. Army. One critical factor in meeting mission is maintaining the optimal health of each soldier. Baseline health data about the RC is currently not being collected, even though increasing numbers of reserve soldiers are being activated. The Annual Health Certification and Survey is being developed as a way to meet the RCs' statutory requirement for annual certification of health while at the same time generating and tracking baseline data on each reservist in a longitudinal health file, the Health Assessment Longitudinal File. This article discusses the Annual Health Certification questionnaire/Health Assessment Longitudinal File, which will greatly enhance the Army's ability to accurately certify the health status of the RC and track health in relation to training, mission activities, and deployment. C1 Washington Univ, Med Ctr, Jewish Hosp, Coll Nursing & Allied Hlth, St Louis, MO 63110 USA. USA Reserve, Off Chief, Washington, DC 20310 USA. USA, Ctr Hlth Promot & Prevent Med, Directorate Hlth Promot & Wellness, Aberdeen Proving Ground, MD 21010 USA. RP Kemper, JA (reprint author), Washington Univ, Med Ctr, Jewish Hosp, Coll Nursing & Allied Hlth, 306 S Kingshighway, St Louis, MO 63110 USA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2003 VL 168 IS 8 BP 631 EP 638 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 743AN UT WOS:000186550400009 PM 12943038 ER PT J AU Stojadinovic, A Brennan, MF Hoos, A Omeroglu, A Leung, DHY Dudas, ME Nissan, A Cordon-Cardo, C Ghossein, RA AF Stojadinovic, A Brennan, MF Hoos, A Omeroglu, A Leung, DHY Dudas, ME Nissan, A Cordon-Cardo, C Ghossein, RA TI Adrenocortical adenoma and carcinoma: Histopathological and molecular comparative analysis SO MODERN PATHOLOGY LA English DT Article DE adenoma; adrenal; carcinoma; IHC; tissue microarray ID TISSUE MICROARRAYS; P21(WAF1/CIP1) EXPRESSION; PROGNOSTIC-SIGNIFICANCE; CANCER SPECIMENS; CELL-LINES; TUMORS; NEOPLASMS; P53; KI-67; PROGRESSION AB We compared histomorphological features and molecular expression profiles of adrenocortical adenomas (ACAd) and carcinomas (ACCa). A critical histopathological review (mean, I I slides per patient) was conducted of 37 ACAd and 67 ACCa. Paraffin-embedded tissue cores of ACAd (n = 33) and ACCa (n = 38) were arrayed in triplicate on tissue microarrays. Expression profiles of p53, mdm-2, p21, Bcl-2, cyclin D I, p27, and Ki-67 were investigated by immunohistochemistry and correlated with histopathology and patient outcome using standard statistical methodology. Median follow-up period was 5 years. Tumor necrosis, atypical mitoses, and >1 mitosis per 50 high-power fields were factors that were highly specific for ACCa (P <.001). Number (0 to 4) of unfavorable markers [Ki-67 (+), p21 (+), p27 (+), mdm-2(-)] expressed was significantly associated with mitotic activity and morphologic. index (i.e., number of adverse morphologic features) and highly predictive of malignancy (P <.001). Ki-67 overexpression occurred in 0 ACAd and 36% ACCa (P <.001) and was significantly associated with mitotic rate and unfavorable morphologic index (P <.001). Tumor necrosis, atypical mitoses, >5 mitoses per 50 high-power fields, sinusoidal invasion, histologic index of >5, and presence of more than two unfavorable molecular markers were associated significantly with metastasis in ACCa. Well-established histopathologic criteria and Ki-67 can specifically distinguish ACCAd from ACCa. Tumor cell proliferation (Ki-67) correlates with mitotic activity and morphologic index. Tumor morphology is a better predictor of metastatic risk in ACCa than current immunohistochemistry-detected cell cycle regulatory and proliferation-associated proteins. C1 Mem Sloan Kettering Canc Ctr, Dept Surg, New York, NY 10021 USA. Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Singapore Management Univ, Sch Econ & Social Sci, Singapore, Singapore. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Gen Surg Serv, 6900 Georgia Ave,NW, Washington, DC 20307 USA. RI LEUNG, Denis Heng Yan/D-1439-2009; OI Brennan, Murray/0000-0003-2358-4371 NR 32 TC 45 Z9 50 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0893-3952 J9 MODERN PATHOL JI Mod. Pathol. PD AUG PY 2003 VL 16 IS 8 BP 742 EP 751 DI 10.1097/01.MP.0000081730.72305.81 PG 10 WC Pathology SC Pathology GA 717HY UT WOS:000185084000002 PM 12920217 ER PT J AU Schreuder-Gibson, HL Realff, ML AF Schreuder-Gibson, HL Realff, ML TI Advanced fabrics SO MRS BULLETIN LA English DT Article DE advanced fabrics; chemical protection; electronics; textiles AB The brief article describes the content of the August 2003 issue of MRS Bulletin focusing on Advanced Fabrics. The six articles will feature reviews of advanced fibers, new fabric constructions and design considerations, materials for novel fabric properties, and the incorporation of new elements within fabric structures to add multifunctional wearable features to clothing. C1 USA, Natick Soldier Ctr, Mat Sci Team, Supporting Sci & Technol Directorate, Natick, MA 01760 USA. USA, Natick Soldier Ctr, Mat Sci Team, Supporting Sci & Technol Directorate, Natick, MA 01760 USA. RP Schreuder-Gibson, HL (reprint author), USA, Natick Soldier Ctr, Mat Sci Team, Supporting Sci & Technol Directorate, Kansas St, Natick, MA 01760 USA. NR 0 TC 4 Z9 4 U1 1 U2 1 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0883-7694 J9 MRS BULL JI MRS Bull. PD AUG PY 2003 VL 28 IS 8 BP 558 EP 563 DI 10.1557/mrs2003.165 PG 6 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 712FK UT WOS:000184786800019 ER PT J AU Barry, J Hill, R Brasser, P Sobera, M Kleijn, CR Gibson, P AF Barry, J Hill, R Brasser, P Sobera, M Kleijn, CR Gibson, P TI Computational fluid dynamics modeling of fabric systems for intelligent garment design SO MRS BULLETIN LA English DT Article DE advanced fabrics; computational fluid dynamics (CFD); computer simulation; diffusion; protective textiles ID HEAT AB Protective clothing provides laboratory and hazardous-materials workers, firefighters, military personnel and others with the means to control their exposure to chemicals, biological materials and heat sources. Dependent on the specific application, the textile materials used in protective clothing must provide high performance in a number of areas, for example impermeability to hazardous chemicals breathability light weight, low cost and durability. Models based on computational fluid dynamics have been developed to predict the performance of protective clothing materials. Such models complement testing by enabling property data from laboratory materials tests to be used in predictions of the performance of integrated multilayer garments under varying environmental conditions. C1 Creare Res & Dev Inc, Hanover, NH 03755 USA. TNO, Prins Maurits Lab, NL-2280 AA Rijswijk, Netherlands. Delft Univ, Kramers Lab, Delft, Netherlands. Delft Univ Technol, Multiscale Phys Dept, NL-2600 AA Delft, Netherlands. USA, Soldier Syst Ctr, Natick, MA 01760 USA. RP Barry, J (reprint author), Creare Res & Dev Inc, Hanover, NH 03755 USA. RI Gibson, Phillip/D-2398-2010; Kleijn, Chris/A-7321-2008; OI Gibson, Phillip/0000-0002-6172-4438; Brasser, Paul/0000-0002-8580-9209 NR 15 TC 13 Z9 13 U1 2 U2 11 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0883-7694 J9 MRS BULL JI MRS Bull. PD AUG PY 2003 VL 28 IS 8 BP 568 EP 573 DI 10.1557/mrs2003.167 PG 6 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 712FK UT WOS:000184786800021 ER PT J AU Schreuder-Gibson, HL Truong, Q Walker, JE Owens, JR Wander, JD Jones, WE AF Schreuder-Gibson, HL Truong, Q Walker, JE Owens, JR Wander, JD Jones, WE TI Chemical and biological protection and detection in fabrics for protective clothing SO MRS BULLETIN LA English DT Article DE advanced fabrics; antimicrobial treatments; biological protection; chemical detection; chemical protection; permeable membranes ID CONDUCTING POLYMER SENSORS; ELECTRONIC NOSE; MICROTUBULES; POLYPYRROLE; NANOFIBERS; MECHANISM; FIBERS; ACID AB Military firefighter, law enforcement, and medical personnel require high-level protection when dealing with chemical and biological threats in many environments ranging from combat to urban agricultural and industrial. Current protective clothing is based on full barrier protection, such as hazardous materials (HAZMAT) suits, or permeable adsorptive protective overgarments such as those used by the US military. New protective garrnet systems are invisioned that contain novel features such as the capability to selectively block toxic chemicals, to chemically destroy toxic materials that contact the fabric and to detect hazardous agents on the surface of the fabric. New technologies being built into advanced fabrics for enhanced chemical and biological protection include selectively permeable membranes, reactive nanoparticles, reactive nanofibers, biocidal fabric treatments and conductive-polymer indicators on optical fibers. C1 USA, Natick Soldier Ctr, Mat Sci Team, Supporting Sci & Technol Directorate, Natick, MA 01760 USA. USAF, Res Lab, AFRL MLQF, Force Protect Branch,Aerosp Technol Div, Tyndall AFB, FL 32403 USA. Auburn Univ, Auburn, AL 36849 USA. SUNY Binghamton, Dept Chem, Binghamton, NY 13902 USA. SUNY Binghamton, Inst Mat Res, Binghamton, NY 13902 USA. NR 44 TC 56 Z9 56 U1 4 U2 30 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0883-7694 J9 MRS BULL JI MRS Bull. PD AUG PY 2003 VL 28 IS 8 BP 574 EP 578 DI 10.1557/mrs2003.168 PG 5 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 712FK UT WOS:000184786800022 ER PT J AU Killgore, WDS Young, AD Femia, LA Bogorodzki, P Rogowska, J Yurgelun-Todd, DA AF Killgore, WDS Young, AD Femia, LA Bogorodzki, P Rogowska, J Yurgelun-Todd, DA TI Cortical and limbic activation during viewing of high- versus low-calorie foods SO NEUROIMAGE LA English DT Article DE fMRI; neuromiaging; food; eating; feeding; amygdala; medial prefrontal cortex; dorsolateral prefrontal cortex; limbic system ID POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL-BLOOD-FLOW; PRIMATE PREFRONTAL NEURONS; NORMAL-WEIGHT WOMEN; SIGNAL-TO-NOISE; ORBITOFRONTAL CORTEX; HUMAN BRAIN; EATING DISORDERS; ANOREXIA-NERVOSA; FUNCTIONAL MRI AB Despite the high prevalence of obesity, eating disorders, and weight-related health problems in modernized cultures, the neural systems regulating human feeding remain poorly understood. Therefore, we applied functional magnetic resonance imaging (fMRI) to study the cerebral responses of 13 healthy normal-weight adult women as they viewed color photographs of food. The motivational salience of the stimuli was manipulated by presenting images from three categories: high-calorie foods, low-calorie foods, and nonedible dining-related utensils. Both food categories were associated with bilateral activation of the amygdala and ventromedial prefrontal cortex. High-calorie foods yielded significant activation within the medial and dorsolateral prefrontal cortex, thalamus, hypothalamus, corpus callosum, and cerebellum. Low-calorie foods yielded smaller regions of focal activation within medial orbitofrontal cortex; primary gustatory/somato-sensory cortex; and superior, middle, and medial temporal regions. Findings suggest that the amygdala may be responsive to a general category of biologically relevant stimuli such as food, whereas separate ventromedial prefrontal systems may be activated depending on the perceived reward value or motivational salience of food stimuli. (C) 2003 Elsevier Science (USA). All rights reserved. C1 Harvard Univ, McLean Hosp, Sch Med, Cognit Neuroimaging Lab, Belmont, MA 02478 USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Neuropsychiat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. OI Killgore, William/0000-0002-5328-0208 NR 56 TC 266 Z9 268 U1 8 U2 29 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 J9 NEUROIMAGE JI Neuroimage PD AUG PY 2003 VL 19 IS 4 BP 1381 EP 1394 DI 10.1016/S1053-8119(03)00191-5 PG 14 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 717GK UT WOS:000185079000011 PM 12948696 ER PT J AU Parsons, GR Hoover, JJ Killgore, KJ AF Parsons, GR Hoover, JJ Killgore, KJ TI Effect of pectoral fin ray removal on station-holding ability of shovelnose sturgeon SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID SCAPHIRHYNCHUS-ALBUS; SWIMMING PERFORMANCE; PALLID STURGEON; PLATORYNCHUS; TEMPERATURE; RESPONSES AB The effect of fin ray removal on swimming performance was evaluated for shovelnose sturgeon Scaphirhynchus platorynchus from the lower Mississippi River. Immediately upon collection, the marginal pectoral fin ray was removed from some fish, and others were left unclipped as a control group. Fish were promptly returned to the laboratory and held in 1,300-L recirculating tanks at 21-26degreesC. After a minimum recovery time of 48 h, individual fish were placed in a 1,000-L, Brett-type swim tunnel, and their ability to maintain station in flowing water by swimming, skimming, or substrate appression was tested by subjecting fish to increasing speeds beginning at 10 cm/s. After a 60-min swimming bout, speed was increased by 10 cm/s. This was repeated until the fish could no longer maintain station. Fin ray removal had no significant effect on critical station-holding speed (CSHS). The CSHS (mean +/- SE) of fin-ray clipped fish was 60.1 +/- 4.2 cm/s, and that of unclipped fish was 59.2 +/- 3.0 cm/s. Correlation analysis and analysis of variance indicated that collection method, water temperature, size of fish, and time spent in the laboratory had no significant effects on CSHS. Tail beat frequency increased with water velocity, but clipped and unclipped fish were not significantly different. Results indicate that removal of the pectoral fin ray has little or no effect on station-holding ability in shovelnose sturgeon. C1 Univ Mississippi, Dept Biol, University, MS 38677 USA. Engn Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Parsons, GR (reprint author), Univ Mississippi, Dept Biol, University, MS 38677 USA. EM bygrp@olemiss.edu NR 35 TC 21 Z9 21 U1 1 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD AUG PY 2003 VL 23 IS 3 BP 742 EP 747 DI 10.1577/M02-088 PG 6 WC Fisheries SC Fisheries GA 717VN UT WOS:000185111600008 ER PT J AU Mascioni, M Sands, JM Palmese, GR AF Mascioni, M Sands, JM Palmese, GR TI Real time in situ spectroscopic characterization of radiation induced cationic polymerization of glycidyl ethers SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 5th International Symposium on Ionizing Radiation and Polymers (IRaP 2002) CY SEP 21-26, 2002 CL ST ADELE, CANADA SP Rech, Sci & Technol Quebec, Ecole Polytech Montreal, DSM DRECAM CEA/Saclay, IOM, IAEA Vienna, Grp COGETEFI, CTT Grp, GEX Corp, Nissin NHV Amer Inc, IBA, Promerus DE electron beam; cationic polymerization; diffusion; chemical kinetics; epoxy; UV ID UV; PHOTOPOLYMERIZATION; PHOTOINITIATOR; KINETICS; BEAMS AB Radiation curable polymeric materials suffer from relatively poor mechanical properties. Moreover, the curing behavior of such systems (i.e. the exact relationship between chemical kinetics and key processing variables) is not fully understood. In order to design improved epoxy based electron beam (EB) curable systems, and in order to develop appropriate process models, a detailed knowledge of the kinetics of epoxy cationic polymerization induced by ultraviolet (UV) or EB irradiation is required. In this work, we present our development of a technique based on real time near infrared (RTIR) spectroscopy for performing in situ kinetic analysis of radiation induced cationic polymerization of epoxy systems. To our knowledge this is the first time such data have been collected and presented for high-energy EB (10 MeV) induced polymerization. A demonstration of the technique for deterministic evaluation of degree of cure is shown using model glycidyl ether (phenyl glycidyl ether and diglycidyl ether of bisphenol A) resins and isothermal curing conditions. The impact of initiation rate on polymerizations with UV and EB for the cationic initiator is directly evident by comparative analysis. The sensitivity of the RTIR method and ability to produce quantitative data evidence of reaction mechanisms is demonstrated. The type of data presented in this work forms the basis for cure models being developed. (C) 2003 Published by Elsevier B.V. C1 Drexel Univ, Dept Chem Engn, Philadelphia, PA 19104 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Chem Engn, Philadelphia, PA 19104 USA. NR 15 TC 12 Z9 12 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD AUG PY 2003 VL 208 BP 353 EP 357 DI 10.1016/S0168-583X(03)00648-7 PG 5 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA 707LT UT WOS:000184512700062 ER PT J AU Waters, WF Magill, RA Bray, GA Volaufova, J Smith, SR Lieberman, HR Rood, J Hurry, M Anderson, T Ryan, DH AF Waters, WF Magill, RA Bray, GA Volaufova, J Smith, SR Lieberman, HR Rood, J Hurry, M Anderson, T Ryan, DH TI A comparison of tyrosine against placebo, phentermine, caffeine, and D-amphetamine during sleep deprivation SO NUTRITIONAL NEUROSCIENCE LA English DT Article DE diurnal rhythm; sleep deprivation; sleep drive; sleep quality; sleep quantity; polysomnography ID SLOW-RELEASE CAFFEINE; COGNITIVE PERFORMANCE; ALERTNESS; MOOD; CATECHOLAMINES; WAKEFULNESS; HUMANS; NARCOLEPSY; PRESSURE; AROUSAL AB Sleep deprivation can impair alertness and cognitive and motor performance. We hypothesized that the amino acid tyrosine might reduce deleterious effects of sleep deprivation. Seventy-six healthy males, age 18-35 years, participated in a four-day protocol that included a habituation night, a baseline night, a 40.5 h period without sleep, and a recovery night. Tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine 37.5 mg, D-amphetamine 20 mg and placebo were administered in a double-blind, randomized fashion to compare their effects on the time it took to fall asleep, on endocrine responses during sleep deprivation, and on sleep quantity, quality and architecture as measured by polysomnography during recovery sleep. When given after 36 h without sleep, tyrosine had no significant effect on any parameter of sleep. D-amphetamine produced marked decrease in sleep drive but caused deleterious effects on many aspects of recovery sleep. Still, D-amphetamine was associated with increased alertness on the first recovery day. Phentermine and caffeine both decreased sleep drive during sleep deprivation, but phentermine impaired rapid-eye-movement (REM) recovery sleep. Tyrosine (when compared to placebo) had no effect on any sleep related measure, but it did stimulate prolactin release. C1 Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA. Louisiana State Univ, Dept Kinesiol, Baton Rouge, LA 70803 USA. USA, Environm Med Res Inst, Baton Rouge, LA USA. RP Ryan, DH (reprint author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA. NR 30 TC 12 Z9 12 U1 0 U2 4 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1028-415X J9 NUTR NEUROSCI JI Nutr. Neurosci. PD AUG PY 2003 VL 6 IS 4 BP 221 EP 235 DI 10.1080/1028415031000120543 PG 15 WC Neurosciences; Nutrition & Dietetics SC Neurosciences & Neurology; Nutrition & Dietetics GA 703PJ UT WOS:000184289000003 PM 12887139 ER PT J AU Magill, RA Waters, WF Bray, GA Volaufova, J Smith, SR Lieberman, HR McNevin, N Ryan, DH AF Magill, RA Waters, WF Bray, GA Volaufova, J Smith, SR Lieberman, HR McNevin, N Ryan, DH TI Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation SO NUTRITIONAL NEUROSCIENCE LA English DT Article DE dirunal rhythm; sleep deprivation; sleep drive; sleep quality; sleep quantity; polysomnography ID SLOW-RELEASE CAFFEINE; PROPHYLACTIC NAPS; ALERTNESS; WAKEFULNESS; VIGILANCE; MOOD; MODAFINIL AB Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation. We administered placebo, tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine 37.5 mg and D-amphetamine 20 mg at 15.30 h following overnight sleep deprivation and compare their effects on cognitive and motor performance in healthy young men. Tests of visual scanning, running memory, logical reasoning, mathematical processing, the Stroop task, four-choice serial reaction time, time wall take, pursuit tracking, visual vigilance, Trails (B) task and long-term memory were evaluated at standardized intervals before, during and after sleep deprivation and drugs. Performance decrements with sleep deprivation occurred in visual scanning, running memory, logical reasoning, mathematical processing, the Stroop test, the time wall test, tracking and visual vigilance. Interestingly, with sleep deprivation some tests improved and others did not deteriorate. Improvements with medication following sleep deprivation were seen in running memory, logical reasoning, mathematical processing, tracking and visual vigilance. Although less effective than D-amphetamine, tyrosine improved performance on several tests. We conclude that all drugs tested improved at least some aspects of cognitive and motor performance after sleep deprivation. As a naturally occurring amino acid, and thus amenable to nutritional strategies, tyrosine may deserve further testing. C1 Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA. Louisiana State Univ, Dept Kinesiol, Baton Rouge, LA 70803 USA. USA, Environm Med Res Inst, Baton Rouge, LA USA. RP Ryan, DH (reprint author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA. NR 22 TC 52 Z9 53 U1 1 U2 10 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1028-415X J9 NUTR NEUROSCI JI Nutr. Neurosci. PD AUG PY 2003 VL 6 IS 4 BP 237 EP 246 DI 10.1080/1028415031000120552 PG 10 WC Neurosciences; Nutrition & Dietetics SC Neurosciences & Neurology; Nutrition & Dietetics GA 703PJ UT WOS:000184289000004 PM 12887140 ER PT J AU Moyer, S Driggers, RG Vollmerhausen, RH Soel, MA Welch, G Rhodes, WT AF Moyer, S Driggers, RG Vollmerhausen, RH Soel, MA Welch, G Rhodes, WT TI Information differences between subbands of the mid-wave infrared spectrum SO OPTICAL ENGINEERING LA English DT Article DE mid-wave infrared spectrum; broadband sensor; multiband imaging ID JOINT MULTISPECTRAL PROGRAM; FIELD-MEASUREMENTS; IMAGER AB The U.S. Army has been investigating the differences between various bands in the mid-wave and long-wave infrared spectrum. A holistic approach to quantifying scene information was used in previous research. That is, both natural backgrounds and vehicles were present in scenes when correlation analyses were performed. Similar research has also been performed using hyperspectral imagers. Hyperspectral imagers inherently have poor signal-to-noise ratio (SNR) due to the spectral bandwidth of the individual images. In the new research reported here, a mid-wave infrared broadband sensor is cold filtered to provide four subbands in the mid-wave region. A multiwaveband sensor is used to collect mid-wave infrared imagery of military vehicles and natural backgrounds. Three blackbody sources are placed at the same range as the vehicles for radiometric calibration. The goal is to collect radiometrically corrected data of various vehicle targets and backgrounds. These data are then processed for comparative analysis. The images are segmented to remove all unwanted imagery from the images under observation. Pair-wise correlations between corresponding spectral images are performed to assess the differences in information content between the subbands. (C) 2003 Society of Photo-Optical Instrumentation Engineers. C1 USA, Commun Elect Res Dev & Engn Ctr, Night Vis Electron Sensors Directorate, Ft Belvoir, VA 22060 USA. FLIR Syst Boston, N Billerica, MA 01862 USA. Georgia Tech Res Inst, Atlanta, GA 30332 USA. RP Moyer, S (reprint author), USA, Commun Elect Res Dev & Engn Ctr, Night Vis Electron Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 13 TC 3 Z9 3 U1 0 U2 0 PU SPIE-INT SOCIETY OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 2003 VL 42 IS 8 BP 2296 EP 2303 DI 10.1117/1.1589027 PG 8 WC Optics SC Optics GA 709ZN UT WOS:000184656600022 ER PT J AU Ngwendson, JN Bedir, E Efange, SMN Okunji, CO Iwu, MM Schuster, BG Khan, IA AF Ngwendson, JN Bedir, E Efange, SMN Okunji, CO Iwu, MM Schuster, BG Khan, IA TI Constituents of Peucedanum zenkeri seeds and their antimicrobial effects SO PHARMAZIE LA English DT Article ID DRUG QIAN-HU; COUMARINS AB The methanol extract of Peucedanum zenkeri L. seeds showed antimicrobial activity which is concentrated in the n-hexane fraction. Bioactivity-guided chromatographic fractionation of the seeds of P. zenkeri led to the isolation and characterization of five major coumarins, umbelliprenin, imperatorin, bergapten, isopimpinellin and byakangelicin, as well as two minor coumarins, 7-methoxy coumarin and 5-hydroxy-8-methoxy psoralen. Amongst the isolated compounds only imperatorin, bergapten and isopimpinellin were found to possess anti-microbial activity. C1 Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, Sch Pharm, University, MS 38677 USA. Univ Mississippi, Dept Pharmacognosy, Sch Pharm, University, MS 38677 USA. Univ Buea, Dept Chem, Buea, Cameroon. Int Ctr Ethnomed & Drug Dev, Nsukka, Nigeria. Bioresources Dev & Conservat Programme, Silver Spring, MD USA. Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC USA. RP Khan, IA (reprint author), Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, Sch Pharm, University, MS 38677 USA. OI Bedir, Erdal/0000-0003-1262-063X NR 15 TC 20 Z9 23 U1 1 U2 2 PU GOVI-VERLAG GMBH PI ESCHBORN PA PHARMAZEUTISCHER VERLAG GINNHEIMER STRASSE 26, D-65760 ESCHBORN, GERMANY SN 0031-7144 J9 PHARMAZIE JI Pharmazie PD AUG PY 2003 VL 58 IS 8 BP 587 EP 589 PG 3 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA 712WY UT WOS:000184823200015 PM 12967040 ER PT J AU Settimi, A Severini, S Mattiucci, N Sibilia, C Centini, M D'Aguanno, G Bertolotti, M Scalora, M Bloemer, M Bowden, CM AF Settimi, A Severini, S Mattiucci, N Sibilia, C Centini, M D'Aguanno, G Bertolotti, M Scalora, M Bloemer, M Bowden, CM TI Quasinormal-mode description of waves in one-dimensional photonic crystals SO PHYSICAL REVIEW E LA English DT Article ID BAND-GAP STRUCTURES; SPONTANEOUS EMISSION; OPEN SYSTEMS; COMPLETENESS; EXPANSION; FINITE AB Quasinormal-mode treatment is extended to the description of scalar field behavior in one-dimensional photonic crystals. A one-dimensional photonic crystal is a particular configuration of an open cavity, where discontinuities of the refractive index give rise to field confinement. This paper presents, for a one-dimensional photonic crystal, a discussion about the completeness of the quasinormal-mode representation and, moreover, a discussion on the complex eigenfrequencies, as well as the corresponding field distribution. The concept of density of modes is also discussed in terms of quasinormal modes. C1 Univ Roma La Sapienza, INFM, Dipartimento Energet, I-00161 Rome, Italy. USA, Missile Command, Ctr Res Dev & Engn, Weapons Sci Directorate,AMSMI RD WS ST, Redstone Arsenal, AL 35898 USA. RP Settimi, A (reprint author), Univ Roma La Sapienza, INFM, Dipartimento Energet, Via A Scarpa 16, I-00161 Rome, Italy. EM concita.sibilia@uniromal.it NR 21 TC 37 Z9 37 U1 1 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD AUG PY 2003 VL 68 IS 2 AR 026614 DI 10.1103/PhysRevE.68.026614 PN 2 PG 11 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 719GC UT WOS:000185194400108 PM 14525140 ER PT J AU Haverkos, HW Chung, RC Perez, LCN AF Haverkos, HW Chung, RC Perez, LCN TI Is there an epidemic of HIV/AIDS among heterosexuals in the USA? SO POSTGRADUATE MEDICAL JOURNAL LA English DT Review AB The Centers for Disease Control and Prevention (CDC), Atlanta, reports HIV infections and AIDS cases in the United States biannually. Trends in the distribution of HIV/AIDS cases according to sex, race or ethnic group, and various categories of exposure to HIV were analysed. The groups in which there were the greatest percentage increases over time were the group with heterosexual contact and the group for whom the risk factors were not reported or identified. The CDC should be encouraged to provide additional information regarding sexual and drug-using behaviours of those patients listed as "undetermined". C1 Walter Reed Army Med Ctr, Dept Med, Infect Dis Serv, Washington, DC 20307 USA. Univ Texas, Hlth Sci Ctr, Div Infect Dis, San Antonio, TX 78284 USA. Natl Med Assoc, Bethesda, MD USA. RP Haverkos, HW (reprint author), HFD-530,5600 Fishers Lane, Rockville, MD 20857 USA. NR 30 TC 4 Z9 4 U1 0 U2 1 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0032-5473 J9 POSTGRAD MED J JI Postgrad. Med. J. PD AUG 1 PY 2003 VL 79 IS 934 BP 444 EP 448 DI 10.1136/pmj.79.934.444 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 717RG UT WOS:000185103300005 PM 12954955 ER PT J AU Murray, JN Stephenson, LD Kumar, A AF Murray, JN Stephenson, LD Kumar, A TI Electrochemical and physical evaluations of coil coatings on metal-coated steels for roofing applications SO PROGRESS IN ORGANIC COATINGS LA English DT Review DE coil-coated galvanized steels; electrochemical evaluations; EIS; cyclic vs. continuous exposures; polyester topcoat; silicone modified polyester topcoat; PVF2 topcoat ID IMPEDANCE AB Four types of commercial organic coil coatings, applied over galvanized and Galvalumed steel, were evaluated for applicability as roofing materials using electrochemical and physical test methods. Scribed candidate coatings were subjected to 13 weeks of cyclic salt-fog and UV exposures via ASTM D 5894 (with modifications). This controlled laboratory exposure approach has been suggested as a practical accelerating alternative to long-term outdoor exposure testing. Electrochemical impedance spectroscopy (EIS), sample potentials and coating disbonding at the scribe lines were used for evaluation. Unscribed samples were also subjected to 13 weeks of continuous immersion in the same test electrolyte composition and evaluated physically and via EIS. The complexity of the coating systems as well as the testing protocol introduced. several evaluation difficulties, especially in the electrochemical testing. The relative merits of the coatings as well as the testing approaches are presented and discussed. (C) 2003 Published by Elsevier B.V. C1 USA, Corps Engineers, ERDC, CERL, Champaign, IL 61826 USA. RP Stephenson, LD (reprint author), USA, Corps Engineers, ERDC, CERL, POB 9005, Champaign, IL 61826 USA. NR 13 TC 12 Z9 14 U1 1 U2 3 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0300-9440 J9 PROG ORG COAT JI Prog. Org. Coat. PD AUG PY 2003 VL 47 IS 2 BP 136 EP 146 DI 10.1016/S0300-9440(03)00114-0 PG 11 WC Chemistry, Applied; Materials Science, Coatings & Films SC Chemistry; Materials Science GA 720NK UT WOS:000185266700007 ER PT J AU Meoli, AL Rosen, CL Kristo, D Kohrman, M Gooneratne, N Aguillard, RN Fayle, R Troell, R AF Meoli, AL Rosen, CL Kristo, D Kohrman, M Gooneratne, N Aguillard, RN Fayle, R Troell, R TI Nonprescription treatments of snoring or obstructive sleep apnea: An evaluation of products with limited scientific evidence SO SLEEP LA English DT Article ID EXTERNAL NASAL DILATOR; PRACTICE PARAMETERS; AIR-FLOW; RESISTANCE; STRIPS; INHALATION; RHINOMETRY; ENZYME AB Purpose: To evaluate the level of evidence regarding the safety and efficacy of nonprescription therapies used to treat snoring and obstructive sleep apnea, and form a consensus statement based on available data. Reviewers: Members of the American Academy of Sleep Medicine's Clinical Practice Review Committee. Methods: A search of PubMed database using MeSH terms snore, apnea, and obstructive sleep apnea in August, 2002, including only articles published in English between 1990 and 2002 and of the World Wide Web, using Google search engine and the key words snoring and obstructive sleep apnea. Letters were sent to manufacturers of lubricant oral and nasal products requesting copies of scientific studies to support their claims. Results and Conclusions: Given the paucity and quality of scientific literature regarding the nonpharmacologic treatment of snoring and obstructive sleep apnea, members of the Clinical Practice Review Committee had insufficient information to develop standards of practice recommendations. Nevertheless, substantial publicity regarding such treatments is available to the general public. Very limited data are available to support a beneficial effect of these devices on snoring and minimal evidence is available to support their use in treating obstructive sleep apnea. Studies are limited by small numbers of participants and, in some instances, inadequate design, lack of statistical analysis, and sparse use of objective measurements. Many studies do not evaluate product safety, especially over extended use. Physicians may find this information useful in counseling their patients. Citation: Report of the Clinical Practice Review Committee, American Academy of Sleep Medicine. Nonprescription treatments of snoring or obstructive sleep apnea: an evaluation of products with limited scientific evidence. C1 St Johns Reg Med Ctr, Joplin, MO USA. Case Western Reserve Univ, Dept Pediat, Rainbow Babies & Childrens Hosp, Cleveland, OH 44106 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Chicago, Chicago, IL 60637 USA. Univ Penn, Div Geriatr Med, Philadelphia, PA 19104 USA. Univ Penn, Ctr Sleep & Resp Neurobiol, Philadelphia, PA 19104 USA. Methodist Hosp, Sleep Disorders Ctr, Memphis, TN USA. Univ Texas, Sch Med, Houston, TX USA. Summerlin Med Towers, Las Vegas, NV USA. RP Meoli, AL (reprint author), St Johns Reg Med Ctr, Joplin, MO USA. NR 47 TC 12 Z9 12 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI ROCHESTER PA 6301 BANDEL RD, STE 101, ROCHESTER, MN 55901 USA SN 0161-8105 J9 SLEEP JI Sleep PD AUG 1 PY 2003 VL 26 IS 5 BP 619 EP 624 PG 6 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 708BN UT WOS:000184546800018 PM 12938818 ER PT J AU Das, NC Newman, P AF Das, NC Newman, P TI Effect of post oxidation annealing on VCSEL performance SO SOLID-STATE ELECTRONICS LA English DT Article ID VERTICAL-CAVITY LASERS; SURFACE-EMITTING LASERS; ALAS; FABRICATION; DEPENDENCE; THICKNESS; KINETICS; LAYER AB Wet oxidation is used for current confinement in 850 nm vertical cavity surface emitting laser (VCSEL) structure. Annealing of wet oxide in nitrogen environment was done at different temperatures. Significant improvement (approximately 18% increase) in VCSEL optical emission power is observed after annealing for 1 h at 400degreesC. From isothermal annealing experiment, it is concluded that the devices annealed at 400degreesC has the maximum annealing rate. From the capacitance versus voltage curve it is observed that negatively charged bulk traps and interface states decrease due to annealing. (C) 2003 Elsevier Science Ltd. All rights reserved. C1 USA, Res Lab, AMSRL SE EM, Adelphi, MD 20783 USA. RP Das, NC (reprint author), USA, Res Lab, AMSRL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 16 TC 3 Z9 5 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD AUG PY 2003 VL 47 IS 8 BP 1359 EP 1362 DI 10.1016/S0038-1101(03)00026-1 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 684VD UT WOS:000183226500013 ER PT J AU Fang, SF Gertner, GZ Shinkareva, S Wang, GX Anderson, A AF Fang, SF Gertner, GZ Shinkareva, S Wang, GX Anderson, A TI Improved generalized Fourier amplitude sensitivity test (FAST) for model assessment SO STATISTICS AND COMPUTING LA English DT Article DE Fourier amplitude sensitivity test (FAST); model assessment; sensitivity analysis; uncertainty assessment ID COUPLED REACTION SYSTEMS; RATE COEFFICIENTS; UNCERTAINTIES; PARAMETERS AB The Fourier amplitude sensitivity test (FAST) can be used to calculate the relative variance contribution of model input parameters to the variance of predictions made with functional models. It is widely used in the analyses of complicated process modeling systems. This study provides an improved transformation procedure of the Fourier amplitude sensitivity test (FAST) for non-uniform distributions that can be used to represent the input parameters. Here it is proposed that the cumulative probability be used instead of probability density when transforming non-uniform distributions for FAST. This improvement will increase the accuracy of transformation by reducing errors, and makes the transformation more convenient to be used in practice. In an evaluation of the procedure, the improved procedure was demonstrated to have very high accuracy in comparison to the procedure that is currently widely in use. C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. Univ Illinois, Dept Psychol, Champaign, IL 61820 USA. USA, Construct Engn Res Labs, Champaign, IL 61826 USA. RI ming-jui, chang/F-9294-2015 NR 13 TC 24 Z9 24 U1 0 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0960-3174 J9 STAT COMPUT JI Stat. Comput. PD AUG PY 2003 VL 13 IS 3 BP 221 EP 226 DI 10.1023/A:1024266632666 PG 6 WC Computer Science, Theory & Methods; Statistics & Probability SC Computer Science; Mathematics GA 690PD UT WOS:000183556800003 ER PT J AU Ardill, W Gidado, S Samson, DS AF Ardill, W Gidado, S Samson, DS TI Penetrating head wound: A remarkable case SO SURGICAL NEUROLOGY LA English DT Article DE injury; brain; trauma AB BACKGROUND The modern management of penetrating head injuries is generally considered a neurosurgical specialty that relies heavily on the use of sequential imaging techniques, an ever-changing armamentarium of sophisticated antibiotics and specific neurosurgical operative skills. Unfortunately these optimal therapeutic components are frequently not available to patients injured in underdeveloped countries. METHODS An unusual case of a young patient suffering a penetrating brain wound and undergoing delayed treatment in an African mission hospital is reviewed. RESULTS A functional but neurologically impaired outcome resulted from limited surgical debridement and short-term broad-spectrum antibiotic administration. CONCLUSIONS The multiple exigencies of surgical practice in an underdeveloped African nation do not preclude successful management of penetrating head trauma. (C) 2003 Elsevier Inc. All rights reserved. C1 Evangel Hosp, Jos, Nigeria. UT SW Med Ctr, Dept Neurosurg, Dallas, TX USA. RP Ardill, W (reprint author), USA, SIM, Box 7900, Charlotte, NC 28241 USA. NR 3 TC 5 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-3019 J9 SURG NEUROL JI Surg. Neurol. PD AUG PY 2003 VL 60 IS 2 BP 120 EP 123 DI 10.1016/S0090-3019(03)00158-7 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 707WB UT WOS:000184531900005 PM 12900113 ER PT J AU Mahanty, S Gupta, M Paragas, J Bray, M Ahmed, R Rollin, PE AF Mahanty, S Gupta, M Paragas, J Bray, M Ahmed, R Rollin, PE TI Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection SO VIROLOGY LA English DT Article DE Ebola virus; filovirus; cytokines; viral kinetics; innate immunity; protective immunity; pathogenesis; interferons ID CYTOTOXIC T-LYMPHOCYTES; HEMORRHAGIC-FEVER; ENDOTHELIAL-CELLS; FILOVIRUS INFECTIONS; VIRAL-INFECTIONS; PASSIVE TRANSFER; ZAIRE-VIRUS; IFN-ALPHA; IN-VITRO; MICE AB A mouse-adapted strain of Ebola Zaire virus produces a fatal infection when BALB/cj mice are infected intraperitoneally (ip) but subcutaneous (sc) infection with the same virus fails to produce illness and confers long-term protection from lethal ip rechallenge. To identify immune correlates of protection in this model, we compared viral replication and cytokine/chemokine responses to Ebola virus in mice infected ip (10 PFU/mouse), or sc (100 PFU/mouse) and sc "immune" mice rechallenged ip (106 PFU/mouse) at several time points postinfection (pi). Ebola viral antigens were detected in the serum, liver, spleen, and kidneys of ip-infected mice by day 2 pi, increasing up to day 6. Sc-infected mice and immune mice rechallenged ip had no detectable viral antigens until day 6 pi, when low levels of viral antigens were detected in the livers of sc-infected mice only. TNF-alpha and MCP-1 were detected earlier and at significantly higher levels in the serum and tissues of ip-infected mice than in sc-infected or immune mice challenged ip. In contrast, high levels of IFN-alpha and IFN-gamma were found in tissues within 2 days after challenge in sc-infected and immune mice but not in ip-infected mice. Mice became resistant to ip challenge within 48 h of sc infection, coinciding with the rise in tissue IFN-alpha levels. In this model of Ebola virus infection, the nonlethal sc route of infection is associated with an attenuated inflammatory response and early production of antiviral cytokines, particularly IFN-alpha, as compared with lethal ip infection. (C) 2003 Elsevier Science (USA). All rights reserved. C1 Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Special Pathogens Branch, Atlanta, GA 30333 USA. Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA. USA, Med Res Inst Infect Dis, Dept Viral Therapeut, Frederick, MD 21702 USA. NIAID, Biodef Clin Res Branch, Off Director, NIH, Bethesda, MD 20892 USA. RP Mahanty, S (reprint author), NIAID, Malaria Vaccine Dev Unit, NIH, Twinbrook 1,5640 Fishers Lane, Rockville, MD 20852 USA. EM smahanty@niaid.nih.gov OI Mahanty, Siddhartha/0000-0003-1068-0524 NR 47 TC 48 Z9 52 U1 0 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD AUG 1 PY 2003 VL 312 IS 2 BP 415 EP 424 DI 10.1016/S0042-6822(03)00233-2 PG 10 WC Virology SC Virology GA 715AH UT WOS:000184948000016 PM 12919746 ER PT J AU Adrian, NR Arnett, CM Hickey, RF AF Adrian, NR Arnett, CM Hickey, RF TI Stimulating the anaerobic biodegradation of explosives by the addition of hydrogen or electron donors that produce hydrogen SO WATER RESEARCH LA English DT Article DE RDX; HMX; TNT; anaerobic; biodegradation; explosives ID 2,4,6-TRINITROTOLUENE TNT TRANSFORMATION; CLOSTRIDIUM-BIFERMENTANS; METHANOGENIC CONDITIONS; MICROBIAL-DEGRADATION; CONTAMINATED SOILS; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; BIOTRANSFORMATION; BACTERIA; RDX; TRIAMINOTOLUENE AB The anaerobic biodegradation of hexahydro-1, 3,5-trinitro-1,3,5-triazine (RDX), octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX), and 2,4,6-trinitrotoluene (TNT) by a methanogenic mixed culture was investigated. Microcosms containing a basal medium and the mixed culture were amended with ethanol, propylene glycol (PG), butyrate or hydrogen gas as the electron donor and a mixture of TNT (50 muM), RDX (25 muM), and HMX (8 muM). After 29 days TNT and RDX were completely transformed to unidentified endproducts in the bottles amended with ethanol, hydrogen, or PG, while 53%, 40%, and 22% of the HMX was transformed, respectively. There was no loss of RDX or HMX in the electron donor unamended control bottles. The ethanol and PG were transformed to near stoichiometric amounts of acetate and propionate, suggesting the immediate electron donor supporting the transformation of the explosives was the H(2) evolved during the metabolism of the parent substrate. Our findings suggest that the addition of H(2) or electron donors that produce H(2) may be a useful strategy for enhancing the anaerobic biodegradation of explosives in contaminated groundwater and soils. Published by Elsevier Science Ltd. C1 USA, Construct Engn Res Lab, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61821 USA. RETEC Grp, Lansing, MI 48910 USA. RP Adrian, NR (reprint author), USA, Construct Engn Res Lab, Corps Engineers, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61821 USA. EM neal.r.adrian@erdc.usace.army.mil NR 26 TC 50 Z9 50 U1 0 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD AUG PY 2003 VL 37 IS 14 BP 3499 EP 3507 DI 10.1016/S0043-1354(03)00240-9 PG 9 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 701LH UT WOS:000184168700023 PM 12834743 ER PT J AU Gourevitch, A Belenky, G Donetsky, D Laikhtman, B Westerfeld, D Trussell, CW An, H Shellenbarger, Z Martinelli, R AF Gourevitch, A Belenky, G Donetsky, D Laikhtman, B Westerfeld, D Trussell, CW An, H Shellenbarger, Z Martinelli, R TI 1.47-1.49-mu m InGaAsP/InP diode laser arrays SO APPLIED PHYSICS LETTERS LA English DT Article AB Continuous-wave power of 25 W at 1.47-mum was obtained from a 20-element, 1-cm-wide, one-dimensional diode laser array mounted in a microchannel water-cooled heat sink. The coolant temperature was 16 degreesC. A two-dimensional array comprising four laser bars achieved a quasi-cw output of 110 W at a wavelength of 1.49 mum, with an 8-9-nm full width at half-maximum spectrum width. The coolant temperature was 18 degreesC. We developed a theoretical model that describes array heating. Thermal resistances of 0.56, 0.4, and 0.34 K/W were experimentally and theoretically determined for arrays with fill factors of 10%, 20%, and 40%, respectively. (C) 2003 American Institute of Physics. C1 SUNY Stony Brook, Stony Brook, NY 11794 USA. USA, NV&ES Directorate, Ft Belvoir, VA 22060 USA. Sarnoff Corp, Princeton, NJ 08543 USA. Hebrew Univ Jerusalem, IL-91904 Jerusalem, Israel. Power Photon Corp, Stony Brook, NY 11794 USA. RP Gourevitch, A (reprint author), SUNY Stony Brook, Stony Brook, NY 11794 USA. NR 5 TC 7 Z9 7 U1 0 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 28 PY 2003 VL 83 IS 4 BP 617 EP 619 DI 10.1063/1.1596379 PG 3 WC Physics, Applied SC Physics GA 704JM UT WOS:000184336600009 ER PT J AU Duffy, PE AF Duffy, PE TI Maternal immunization and malaria in pregnancy SO VACCINE LA English DT Article; Proceedings Paper CT International Symposium on Protection of Newborns through Maternal Immunization CY DEC 08-11, 2002 CL VEYRIER DU LAC, FRANCE SP Fdn Merieux, WHO DE malaria; Plasmodium falciparum; low birth weight; immunization ID LOW-BIRTH-WEIGHT; FALCIPARUM-INFECTED ERYTHROCYTES; CHONDROITIN SULFATE-A; PLACENTAL MALARIA; PLASMODIUM-FALCIPARUM; IMMUNE-RESPONSE; HAEMOPHILUS-INFLUENZAE; IMMUNOGLOBULIN LEVELS; CONJUGATE VACCINE; ANTIBODY TRANSFER AB Malaria in pregnancy is a major cause of poor outcomes for both mother and fetus, and malaria-induced low birth weight (LBW) may kill nearly 400,000 African infants each year. The hallmark of pregnancy malaria due to Plasmodium falciparum is the sequestration of infected erythrocytes (IEs) in the placenta. Malaria can suppress responses to immunogens, and placental malaria can impair materno-fetal antibody transfer, potentially reducing the benefits of maternal immunization strategies. Parasites infecting the placenta have been shown to have distinct adhesive and antigenic features. Women become resistant to pregnancy malaria over successive pregnancies as they acquire antibodies that recognize placental parasites, suggesting that a vaccine is feasible. Serologic evidence indicates that the target for such a vaccine is antigenically conserved, and surface proteins expressed by placental parasites have been identified as vaccine candidates. Because malaria suppresses vaccine responses and reduces the transfer of maternal antibodies to the fetus, the prevention of pregnancy malaria may benefit maternal immunization strategies that protect neonates from infections other than malaria. Published by Elsevier Science Ltd. C1 Seattle Biomed Res Inst, Malaria Antigen Discovery Program, Seattle, WA 98119 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, Malaria Antigen Discovery Program, 4 Nickerson St,Suite 200, Seattle, WA 98119 USA. FU NIAID NIH HHS [R01 AI43680, R01 AI52059] NR 35 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 28 PY 2003 VL 21 IS 24 BP 3358 EP 3361 DI 10.1016/S0264-410X(03)00332-3 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 705NZ UT WOS:000184402300003 PM 12850339 ER PT J AU Peirson, WL Garcia, AW Pells, SE AF Peirson, WL Garcia, AW Pells, SE TI Water wave attenuation due to opposing wind SO JOURNAL OF FLUID MECHANICS LA English DT Article ID SURFACE GRAVITY-WAVES; ATMOSPHERIC-PRESSURE; SEA WAVES; TURBULENCE; FLOW; DISTORTION; INTERFACE; STRESS AB A laboratory investigation of the attenuation of mechanically generated waves by an opposing wind has been completed. Wave attenuation was quantified by measurements of the decline in surface variance. These measurements show higher effective levels of monochromatic wave attenuation than predicted by air-side measurements: approximately an order of magnitude higher than measurements by Young & Sobey (1985) and, a factor of 3 higher than those of Donelan (1999) for waves in a JONSWAP spectrum. Furthermore, they show that theoretical estimates currently underestimate the attenuation rates by a factor of at least 3. This study has shown that the magnitude of wave attenuation rates due to opposing winds is approximately 2.5 times greater than the magnitude of wave growth rates for comparable wind forcing. At high wave steepnesses, detailed analysis suggests that air-side processes alone are not sufficient to induce the observed levels of attenuation. Rather, it appears that energy fluxes from the wave field due to the interaction between the wave-induced currents and other subsurface motions play a significant role once the mean wave steepness exceeds a critical value. A systematic relationship between the energy flux from the wave field and mean wave steepness was observed. The combination of opposing wind and wind-induced water-side motions is far more effective in attenuating waves than has previously been envisaged. C1 Univ New S Wales, Sch Civil & Environm Engn, Water Res Lab, Sydney, NSW 2052, Australia. United States Army Corps Engn, Coastel & Hydraul Lab, Vicksburg, MS USA. RP Peirson, WL (reprint author), Univ New S Wales, Sch Civil & Environm Engn, Water Res Lab, Sydney, NSW 2052, Australia. OI Peirson, William/0000-0001-8775-5200 NR 35 TC 16 Z9 16 U1 2 U2 4 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH ST, NEW YORK, NY 10011-4221 USA SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD JUL 25 PY 2003 VL 487 BP 345 EP 365 DI 10.1017/S0022112003004750 PG 21 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 715HU UT WOS:000184966600013 ER PT J AU Xu, DW Carbonell, RG Kiserow, DJ Roberts, GW AF Xu, DW Carbonell, RG Kiserow, DJ Roberts, GW TI Kinetic and transport processes in the heterogeneous catalytic hydrogenation of polystyrene SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID POLY(VINYLCYCLOHEXANE) AB The heterogeneous catalytic hydrogenation of polystyrene (PS) dissolved in decahydronaphthalene was studied in a batch reactor using 5% Pd/BaSO4 as the catalyst. The effects of temperature and H-2 partial pressure were investigated over the ranges from 90 to 180 degreesC and 1.72 to 6.89 MPa. The PS concentration ranged from 1 to 9 wt %. The rate of ring hydrogenation was approximately first-order with respect to PS, with an apparent activation energy of 59.6 kJ/mol. The hydrogenation rate depended on the agitation rate up to a threshold value, which increased with the concentration of PS in the solution. The possible influence of three mass-transfer steps (H2 transport from the gas into the polystyrene solution, PS transport to the surface of the catalyst particles, and PS diffusion in the pores of the catalyst) is analyzed. The last two steps do not appear to be kinetically important at the conditions of this study. C1 N Carolina State Univ, Dept Chem Engn, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Roberts, GW (reprint author), N Carolina State Univ, Dept Chem Engn, Box 7905, Raleigh, NC 27695 USA. NR 29 TC 17 Z9 18 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD JUL 23 PY 2003 VL 42 IS 15 BP 3509 EP 3515 DI 10.1021/ie0301841 PG 7 WC Engineering, Chemical SC Engineering GA 703JJ UT WOS:000184276000001 ER PT J AU Hill, SC AF Hill, SC TI Method for integrating the absorption cross sections of spheres over wavelength or diameter SO APPLIED OPTICS LA English DT Article ID MORPHOLOGY-DEPENDENT RESONANCES; MIE SCATTERING; DIELECTRIC SPHERES; RAMAN LIDAR; WATER; MICRODROPLETS; MICROSPHERES; PARTICLES; FLUORESCENCE; MOLECULES AB The absorption cross sections of spherical particles and droplets must be integrated over frequency or droplet size or both for various applications. Morphology-dependent resonances (MDRs) of the spheres can make evaluation of such integrals difficult because the MDRs can contribute significantly to the integrals even when their linewidths are extremely narrow, especially when the absorption is weak. A method of evaluating these integrals by use of Lorentzian approximations near MDRs is described. Calculated frequency-integrated absorption cross sections illustrate how the method obtains accurate cross sections with far fewer integration points than a method that uses equally spaced points. The method reported here suggests a way to integrate over frequency in more-complicated scattering and emission problems and should also be useful for integrating scattering and absorption by other shapes, e.g., spheroids and cylinders, for which the MDR positions and linewidths can be calculated. (C) 2003 Optical Society of America. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM shill@arl.army.mil NR 48 TC 6 Z9 6 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 2003 VL 42 IS 21 BP 4381 EP 4388 DI 10.1364/AO.42.004381 PG 8 WC Optics SC Optics GA 702YJ UT WOS:000184252300019 PM 12921289 ER PT J AU Hanley, KA Manlucu, LR Gilmore, LE Blaney, JE Hanson, CT Murphy, BR Whitehead, SS AF Hanley, KA Manlucu, LR Gilmore, LE Blaney, JE Hanson, CT Murphy, BR Whitehead, SS TI A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4 SO VIROLOGY LA English DT Article DE flavivirus; dengue virus; vaccine; NS4B; mutation; Aedes aegypti; Vero; HuH-7; C6/36; Toxorhynchites splendens ID HUMAN LIVER-CELLS; SINDBIS VIRUS; HOST-RANGE; VACCINE CANDIDATE; AEDES-ALBOPICTUS; NONCODING REGION; ATTENUATION; IMMUNOGENICITY; MUTAGENESIS; MUTANTS AB An acceptable live-attenuated dengue virus vaccine candidate should have low potential for transmission by mosquitoes. We have identified and characterized a mutation in dengue virus type 4 (DEN4) that decreases the ability of the virus to infect mosquitoes. A panel of 1248 mutagenized virus clones generated previously by chemical mutagenesis was screened for decreased replication in mosquito C6/36 cells but efficient replication in simian Vero cells. One virus met these criteria and contained a single coding mutation: a C-to-U mutation at nucleotide 7129 resulting in a Pro-to-Leu change in amino acid 101 of the nonstructural 4B gene (NS4B P101L). This mutation results in decreased replication in C6/36 cells relative to wild-type DEN4, decreased infectivity for mosquitoes, enhanced replication in Vero and human HuH-7 cells, and enhanced replication in SCID mice implanted with HuH-7 cells (SCID-HuH-7 mice). A recombinant DEN4 virus (rDEN4) beating this mutation exhibited the same set of phenotypes. Addition of the NS413 P101L mutation to rDEN4 bearing a 30 nucleotide deletion (Delta30) decreased the ability of the double-mutant virus to infect mosquitoes but increased its ability to replicate in SCID-HuH-7 mice. Although the NS4B P101L mutation decreases infectivity of DEN4 for mosquitoes, its ability to enhance replication in SCID-HuH-7 mice suggests that it might not be advantageous to include this specific mutation in an rDEN4 vaccine. The opposing effects of the NS413 P10IL mutation in mosquito and vertebrate systems suggest that the NS4B protein is involved in maintaining the balance between efficient replication in the mosquito vector and the human host. (C) 2003 Elsevier Science (USA). All rights reserved. C1 NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20955 USA. RP Hanley, KA (reprint author), NIAID, Infect Dis Lab, NIH, Bldg 50,Room 6515,50 South Dr, Bethesda, MD 20892 USA. NR 38 TC 61 Z9 62 U1 2 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JUL 20 PY 2003 VL 312 IS 1 BP 222 EP 232 DI 10.1016/S0042-6822(03)00197-1 PG 11 WC Virology SC Virology GA 708EF UT WOS:000184553600021 PM 12890635 ER PT J AU Makshtas, AP Shoutilin, SV Andreas, EL AF Makshtas, AP Shoutilin, SV Andreas, EL TI Possible dynamic and thermal causes for the recent decrease in sea ice in the Arctic Basin SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article DE sea ice thinning; Arctic climate; energy exchange; ridges; leads; dynamic thermodynamic sea ice model ID THICKNESS DISTRIBUTION; FRAM STRAIT; UPPER-OCEAN; PACK ICE; MODEL; VARIABILITY; CLIMATE; CIRCULATION; COVER; FLUX AB [1] A dynamic-thermodynamic sea ice model with 50-km spatial and 24-hour temporal resolution was used to investigate the spatial and temporal variability of the sea ice cover and the surface energy exchange in the Arctic Basin. Daily surface level air temperature and pressure data from National Centers for Environmental Prediction for 1958-1997 and climatic data for cloudiness, relative humidity, snow precipitation, and the heat flux from the deep ocean in the Greenland, Barents, and Bering Seas were used as external forcing. The model is integrated using the method of large particles [Belotserkovskii, 1984]. The model satisfactorily reproduces the seasonal and interannual variability of the main characteristics of the sea ice, the sea ice extent and exchange through the main straits, and the surface heat exchange for different parts of the Arctic Basin. In particular, estimates of the year-to-year difference between mean sea ice thickness in September show good agreement with the essential thinning of sea ice in the Canadian Basin that Rothrock et al. [1999] found. Most of the decrease in sea ice thickness is caused by a decrease in ridge concentration and an increase in the area covered by undeformed ice. Numerical experiments show that only 20% of the ice decrease can be explained by an increase in surface level air temperature. Model results for the Canadian and Eurasian Basins allow us to determine the main trends in the temporal variability of ice thickness in these regions. Our model results suggest that the recent thinning of the sea ice correlates with a decrease in the concentration of ridged ice. In turn, the concentration of ridged ice and the total sea ice volume in the Canadian Basin correlate with cyclonic and anticyclonic regimes of the wind-driven ice motion. The sharp decrease in modeled ice volume in the Canadian Basin after 1987 also coincides with a significant increase in the mean atmospheric vorticity index for the central Arctic Ocean. C1 Univ Alaska Fairbanks, Int Arctic Res Ctr, Fairbanks, AK 99775 USA. Arctic & Antarctic Res Inst, St Petersburg 199226, Russia. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Makshtas, AP (reprint author), Univ Alaska Fairbanks, Int Arctic Res Ctr, 930 Koyukuk Dr,POB 757335, Fairbanks, AK 99775 USA. EM makshtas@iarc.uaf.edu NR 59 TC 15 Z9 15 U1 0 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JUL 18 PY 2003 VL 108 IS C7 AR 3232 DI 10.1029/2001JC000878 PG 13 WC Oceanography SC Oceanography GA 709BY UT WOS:000184605900001 ER PT J AU Ashani, Y Bhattacharjee, AK Leader, H Saxena, A Doctor, BP AF Ashani, Y Bhattacharjee, AK Leader, H Saxena, A Doctor, BP TI Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators SO BIOCHEMICAL PHARMACOLOGY LA English DT Article; Proceedings Paper CT United States Army Medical Defense Bioscience Review Conference CY JUN 04-09, 2000 CL HUNT VALLEY, MARYLAND DE cholinesterases; inhibition; decomposition; organophosphates; phosphonyl oximes; ab initio ID ACTIVE-SITE GORGE; HUMAN BUTYRYLCHOLINESTERASE; ALKALINE HYDROLYSIS; REACTION-PRODUCTS; ACETYLCHOLINESTERASE; SPECIFICITY; BINDING; ESTERS; CONSTANTS; RESIDUES AB Oxime-induced reactivation of phosphonylated cholinesterases (ChEs) produces charged phosphonyl pyridine oxime intermediates (POXs) that are most potent organophosphate (OP) inhibitors of ChEs. To understand the role of cationic pyridine oxime leaving groups in the enhanced anti-ChE activity of POXs, the bimolecular rate constants for the inhibition (k(i)) of acetylcholinesterases (AChE) and butyrylcholinesterases (BChE), and the rate of decomposition (k(d)) of authentic O-alkyl methylphosphonyl pyridine oximes (AlkMeP-POXs) and N,N-dimethylamidophosphoryl pyridine oximes (EDMP-POXs), were studied. Stability ranking order in aqueous solutions correlated well with the electronic features and optimized geometries that were obtained by ab initio calculations at 6-31G** basis set level. AlkMeP-POXs of the 2-pyridine oxime series were found to be 4- to 8-fold more stable (t(1/2) = 0.7 to 1.5 min) than the homologous O,O-diethylphosphoryl (DEP) oxime. Results suggest that re-inhibition of enzyme activity by POX is less likely during the reactivation of DEP-ChEs (obtained by use of DEP-containing pesticides) by certain oximes, compared to nerve agent-inhibited ChEs. The greatest inhibition was observed for the O-cyclohexyl methylphosphonyl-2PAM derivative (4.0 x 10(9) M-1 min(-1); mouse AChE) and is 10-fold higher than the k(i) of cyclosarin. Increasing the size of the O-alkyl substituent of AlkMeP-POXs had only a small to moderate effect on the ki of ChEs, signifying a major role for the cationic pyridine oxime leaving group in the inhibition reaction. The shape of plots of log k(i) vs. pK(a) of the leaving groups for AlkMeP-PAMs and DEP-PANIs, could be used as a diagnostic tool to highlight and rationalize the unique properties of the cationic moiety of pyridine oxime reactivators. (C) 2003 Elsevier Science Inc. All rights reserved. C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. NR 47 TC 59 Z9 61 U1 3 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD JUL 15 PY 2003 VL 66 IS 2 BP 191 EP 202 DI 10.1016/S0006-2952(03)00204-1 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 699HX UT WOS:000184051900002 PM 12826262 ER PT J AU Aron, JL Parthun, MR Marcucci, G Kitada, S Mone, AP Davis, ME Shen, TS Murphy, T Wickham, J Kanakry, C Lucas, DM Reed, JC Grever, MR Byrd, JC AF Aron, JL Parthun, MR Marcucci, G Kitada, S Mone, AP Davis, ME Shen, TS Murphy, T Wickham, J Kanakry, C Lucas, DM Reed, JC Grever, MR Byrd, JC TI Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein SO BLOOD LA English DT Article ID CHROMOBACTERIUM-VIOLACEUM NO-968; ACUTE PROMYELOCYTIC LEUKEMIA; HYDROXAMIC ACID SAHA; GENE-EXPRESSION; TRANSCRIPTIONAL REPRESSION; MITOCHONDRIAL DAMAGE; LYSINE-9 METHYLATION; IN-VIVO; INDUCTION; CANCER AB Depsipeptide is in clinical trials for chronic lymphocytic leukemia (CLL) on the basis of earlier observations demonstrating selective in vitro activity in CILL. We sought to determine the relationship of histone H3 and H4 acetylation, inhibition of histone deacetylase, and apoptosis observed in CLL cells to justify a pharmacodynamic end point in these clinical trials. We demonstrate that in vitro depsipeptide induces histone H3 and H4 acetylation and histone deacetylase enzyme inhibition at concentrations corresponding to the LC50 (concentration producing 50% cell death) for cultured CLL cells (0.038 muM depsipeptide). The changes histone acetylation are lysine involving H4 K5, H4 K12, and H3 K9, to a lesser extent H4 K8, but not H4 K16 H3 K14. Depsipeptide-induced is caspase dependent, selectively involving the tumor necrosis factor (TNF) (extrinsic pathway) initiating 8 and effector caspase 3. Activation 8 was accompanied by the regulation of cellular FLICE-inhibitory (c-FLIP, I-FLICE) without evidence Fas (CD95) up-regulation. Changes apoptotic proteins, including Bax, Mcl-1, and X-linked inhibitor of ptosis (XIAP), were not observed. Our results demonstrate a relationship between target enzyme inhibition of histone deacetylase, histone H3 and H4 acetylation, and apoptosis involving the TNF-receptor pathway of apoptosis that is not used by other therapeutic agents in CLL. These data suggest use of histone H3 and H4 acetylation, inhibition of histone deacetylase, and clown-regulation of FLIP as pharmacodynamic end points for further evaluation of this drug in patients. (C) 2003 by The American Society of Hematology. C1 Ohio State Univ, Div Hematol Oncol, Dept Internal Med, Columbus, OH 43210 USA. Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA. Canc Res Ctr, Burnham Inst, La Jolla, CA USA. Brooke Army Med Ctr, Div Hematol Oncol 4, San Antonio, TX USA. RP Byrd, JC (reprint author), Ohio State Univ, Div Hematol Oncol, Dept Internal Med, Starling Loving Hall,Rm 302, Columbus, OH 43210 USA. RI Forkel, Stephanie/A-4018-2011; Lucas, David/E-3555-2011 OI Forkel, Stephanie/0000-0003-0493-0283; FU NCI NIH HHS [P30 CA16058, P01 CA81534-02, CA96323-01] NR 54 TC 126 Z9 130 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD JUL 15 PY 2003 VL 102 IS 2 BP 652 EP 658 DI 10.1182/blood-2002-12-3794 PG 7 WC Hematology SC Hematology GA 699XY UT WOS:000184083500044 PM 12649137 ER PT J AU Zhao, AP McDermott, J Urban, JF Gause, W Madden, KB Yeung, KA Morris, SC Finkelman, FD Shea-Donohue, T AF Zhao, AP McDermott, J Urban, JF Gause, W Madden, KB Yeung, KA Morris, SC Finkelman, FD Shea-Donohue, T TI Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves SO JOURNAL OF IMMUNOLOGY LA English DT Article ID EPITHELIAL-CELL FUNCTION; PROTECTIVE IMMUNITY; TRICHINELLA-SPIRALIS; MICE; INFLAMMATION; INFECTIONS; HYPERCONTRACTILITY; INTERLEUKIN-4; PARASITISM; CYTOKINES AB IL-4 and IL-13 promote gastrointestinal worm expulsion in part through effects on nonlymphoid cells, such as intestinal smooth muscle cells. The roles of Stat6 in IL-4-, IL-13-, and parasitic nematode-induced effects on small intestinal smooth muscle contractility were investigated in BALB/c wild-type and Stat6-deficient mice treated with a long-lasting formulation of recombinant mouse IL-4 (IL-4C) or IL-13 for 7 days. Separate groups of BALB/c mice were infected with Nippostrongylus brasiliensis or were drug-cured of an initial Heligmosomoides polygyrus infection and later reinfected. Infected mice were studied 9 and 12 days-after inoculation, respectively. Segments of jejunum were suspended in an organ bath, and responses to nerve stimulation and to acetylcholine and substance P in the presence and absence of tetradotoxin, a neurotoxin, were determined. Both IL-4 and IL-13 increased smooth muscle responses to nerve stimulation in wild-type mice, but the effects were greater in IL-13-treated mice and were absent in IL-13-treated Stat6-deficient mice. Similarly, hypercontractile responses to nerve stimulation in H. polygyrus- and N. brasiliensis-infected mice were dependent in part on Stat6. IL-13, H. polygyrus, and N. brasiliensis, but not IL-4, also increased contractility to acetylcholine by mechanisms that involved Stat6 and enteric nerves. These studies demonstrate that both IL-4 and IL-13 promote intestinal smooth muscle contractility, but by different mechanisms. Differences in these effects correlate with differences in the relative importance of these cytokines in the expulsion of enteric nematode parasites. C1 ARS, Nutr Requirements & Funct Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Pediat, Div Immunol, Washington, DC 20307 USA. Univ Cincinnati, Dept Med, Cincinnati, OH 45267 USA. Univ Cincinnati, Dept Pediat, Cincinnati, OH 45267 USA. Vet Adm Med Ctr, Cincinnati, OH 45220 USA. RP Shea-Donohue, T (reprint author), ARS, Nutr Requirements & Funct Lab, Beltsville Human Nutr Res Ctr, USDA, 10300 Baltimore Ave, Beltsville, MD 20705 USA. OI Urban, Joseph/0000-0002-1590-8869 FU NIAID NIH HHS [R01 AI/DK49316, R01AI35987-06, R01 AI049316] NR 26 TC 111 Z9 111 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JUL 15 PY 2003 VL 171 IS 2 BP 948 EP 954 PG 7 WC Immunology SC Immunology GA 700BY UT WOS:000184093800057 PM 12847266 ER PT J AU Pitisuttithum, P Nitayaphan, S Thongcharoen, P Khamboonruang, C Kim, J de Souza, M Chuenchitra, T Garner, RP Thapinta, D Polonis, V Ratto-Kim, S Chanbancherd, P Chiu, J Birx, DL Duliege, AM McNeil, JG Brown, AE AF Pitisuttithum, P Nitayaphan, S Thongcharoen, P Khamboonruang, C Kim, J de Souza, M Chuenchitra, T Garner, RP Thapinta, D Polonis, V Ratto-Kim, S Chanbancherd, P Chiu, J Birx, DL Duliege, AM McNeil, JG Brown, AE CA Thai AIDS Vaccine Evaluation Grp TI Safety and immunogenicity of combinations of recombinant subtype E and B human immunodeficiency virus type 1 envelope glycoprotein 120 vaccines in healthy Thai adults SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 13th International AIDS Conference CY JUL 09-14, 2000 CL DURBAN, SOUTH AFRICA ID INJECTING DRUG-USERS; CANDIDATE AIDS VACCINES; NEUTRALIZING ANTIBODIES; UNINFECTED RECIPIENTS; HIV-1 INFECTION; GP120; MN; IMMUNIZATION; INDUCTION; BANGKOK AB Safety and immunogenicity of 2 recombinant human immunodeficiency virus (HIV) type 1 envelope glycoprotein (gp) 120 vaccines derived from SF2 ( subtype B) and CM235 ( CRF01_AE, Thai E) were evaluated in 370 Thai adults at low risk of HIV infection. Various doses of CM235 (25, 50, or 100 mug) and SF2 (0, 25, or 50 mug) gp120 were used. Eighty volunteers received placebo. There were no serious adverse events related to vaccination. Binding antibody developed in all vaccine recipients. There was no dose response to CM235 gp120, but a dose response to gp120 SF2 was present. Neutralizing antibodies to subtype E HIV-1 NPO3 and subtype B HIV-1 SF2 developed in 84% and 82% of vaccine recipients, respectively. Lymphoproliferative responses were detected in >95% of vaccine recipients. There was no evidence of antigenic interference in HIV-specific humoral or cellular responses. The gp120 Thai E and SF2 vaccines were safe and immunogenic in combination and could be advanced into phase 3 testing. C1 Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Vaccine Trial Ctr, Bangkok 10400, Thailand. Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10400, Thailand. US Components Armed Forces Res Inst Med Sci, Bangkok, Thailand. Royal Thai Army Inst Pathol, Bangkok, Thailand. Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. Chiang Mai Univ, Fac Nursing, Chiang Mai 50000, Thailand. Walter Reed Army Inst Res, Rockville, MD USA. Henry M Jackson Fdn, Rockville, MD USA. Chiron Vaccines, Emeryville, CA USA. RP Pitisuttithum, P (reprint author), Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Vaccine Trial Ctr, 420-6 Rajvithi Rd, Bangkok 10400, Thailand. NR 32 TC 52 Z9 53 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 15 PY 2003 VL 188 IS 2 BP 219 EP 227 DI 10.1086/376506 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 699HT UT WOS:000184051500005 PM 12854076 ER PT J AU Sen, P Batra, IP Sivananthan, S Grein, CH Dhar, N Ciraci, S AF Sen, P Batra, IP Sivananthan, S Grein, CH Dhar, N Ciraci, S TI Electronic structure of Te- and As-covered Si(211) SO PHYSICAL REVIEW B LA English DT Article ID BEAM EPITAXIAL-GROWTH; SURFACE-STRUCTURE; AB-INITIO; SI(112); PSEUDOPOTENTIALS; SILICON; ENERGY; LEED; SI AB Electronic and atomic structures of the clean and As- and Te-covered Si(211) surface are studied using pseudopotential density-functional method. The clean surface is found to have (2x1) and rebonded (1x1) reconstructions as stable surface structures, but no pi-bonded chain reconstruction. Binding energies of As and Te adatoms at a number of symmetry sites on the ideal and (2x1) reconstructed surfaces have been calculated because of their importance in the epitaxial growth of CdTe and other materials on the Si(211) surface. The special symmetry sites on these surfaces having the highest binding energies for isolated As and Te adatoms are identified. But more significantly, several sites are found to be nearly degenerate in binding-energy values. This has important consequences for epitaxial growth processes. Optimal structures calculated for 0.5 monolayer of As and Te coverage reveal that the As adatoms dimerize on the surface while the Te adatoms do not. However, both As- and Te-covered surfaces are found to be metallic in nature. C1 Univ Illinois, Dept Phys, Chicago, IL 60607 USA. USA, Res Lab, Adelphi, MD 20783 USA. Bilkent Univ, Dept Phys, TR-06533 Ankara, Turkey. RP Sen, P (reprint author), Univ Illinois, Dept Phys, Chicago, IL 60607 USA. RI Sen, Prasenjit/F-4713-2010 OI Sen, Prasenjit/0000-0002-6334-0091 NR 23 TC 9 Z9 9 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD JUL 15 PY 2003 VL 68 IS 4 AR 045314 DI 10.1103/PhysRevB.68.045314 PG 9 WC Physics, Condensed Matter SC Physics GA 720AZ UT WOS:000185239600065 ER PT J AU Elsayed, NM Gorbunov, NV AF Elsayed, NM Gorbunov, NV TI Interplay between high energy impulse noise (blast) and antioxidants in the lung SO TOXICOLOGY LA English DT Article DE impulse noise; blast overpressure; terrorist bombings; mines; antioxidants; oxidative stress; nitric oxide; adult respiratory distress syndrome (ARDS) ID INDUCED HEARING-LOSS; NITRIC-OXIDE; EXERCISE PERFORMANCE; COCHLEAR DAMAGE; BOMB EXPLOSION; VITAMIN-C; INJURY; EXPOSURE; OVERPRESSURE; OXIDATION AB High-energy impulse noise (BLAST) is a physical event characterized by an abrupt rise in atmospheric pressure above ambient lasting for a very short period, but potentially causing significant material and biological damage. Exposure to high-level BLAST can be destructive and lethal. Low-level BLAST similar to what is encountered repeatedly by military personnel during training and combat from detonation of munitions and firing of large caliber weapons, and during occupational use of explosives and some heavy machinery, can also cause significant injury. Globally, civilians are increasingly exposed to BLAST resulting from terrorist bombings or abandoned unmarked mines following numerous wars and conflicts. We have shown previously in several animal models that exposure to non-lethal BLAST results in pathological changes, mostly to the hollow organs characterized in the lungs, the most sensitive organ, by rupture of alveolar septa, and pulmonary hemorrhage and edema. These events potentially can cause alveolar flooding, respiratory insufficiency and adult respiratory distress syndrome (ARDS), leading to varying degrees of hypoxia, antioxidant depletion and oxidative damage. We have also observed progressive formation of nitric oxide in blood and other tissues. The totality of these observations supports our general hypothesis that exposure to BLAST can lead to antioxidant depletion and oxidative damage. Understanding the mechanism(s) of BLAST-induced oxidative stress may have important implications that include a potential beneficial role for antioxidants as a prophylaxis or as secondary treatment of injury after exposure alongside other protective and therapeutic modalities. In addition, it suggests a role for endogenous nitric oxide in the injury. This report reviews experimental evidence of BLAST-induced antioxidant depletion, and the potential benefit from antioxidant supplementation before exposure. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. C1 Walter Reed Army Inst Res, Dept Resp Res, Div Mil Casualty Res, Silver Spring, MD USA. RP Elsayed, NM (reprint author), Hurley Consulting Associates, 1 Main St, Chatham, NJ 07928 USA. NR 66 TC 16 Z9 17 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD JUL 15 PY 2003 VL 189 IS 1-2 BP 63 EP 74 DI 10.1016/S0300-483X(03)00153-7 PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 700QE UT WOS:000184122000005 PM 12821283 ER PT J AU Kirk, AD Hale, DA Mannon, RB Kleiner, DE Hoffmann, SC Kampen, RL Cendales, LK Tadaki, DK Harlan, DM Swanson, SJ AF Kirk, AD Hale, DA Mannon, RB Kleiner, DE Hoffmann, SC Kampen, RL Cendales, LK Tadaki, DK Harlan, DM Swanson, SJ TI Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H) SO TRANSPLANTATION LA English DT Article ID TRANSPLANTATION TOLERANCE; INDUCTION THERAPY; T-CELLS; KIDNEY; EXPRESSION; RECIPIENTS; SURVIVAL; REPERFUSION; APOPTOSIS; REJECTION AB Background. Profound T-cell depletion before allotransplantation with gradual posttransplant T-cell repopulation induces a state of donor-specific immune hyporesponsiveness or tolerance in some animal models. Alemtuzumab (Campath-1H, Millennium Pharmaceuticals, Cambridge, MA) is a humanized CD52-specific monoclonal antibody that produces profound T-cell depletion in humans and reduces the need for maintenance immunosuppression after renal transplantation. We therefore performed a study to determine if pretransplant T-cell depletion with alemtuzumab would induce tolerance in human renal allografts and to evaluate the nature of the alloimmune response in the setting of T-cell depletion. Methods. Seven nonsensitized recipients of living-donor kidneys were treated perioperatively with alemtuzumab and followed postoperatively without maintenance immunosuppression. Patients were evaluated clinically by peripheral flow cytometry, protocol biopsies evaluated immunohistochemically, and real-time polymerase chain reaction-based transcriptional analysis. Results. Lymphocyte depletion was profound in the periphery and secondary lymphoid tissues. All patients developed reversible rejection episodes within the first month that were characterized by predominantly monocytic (not lymphocytic) infiltrates with only rare T cells in the peripheral blood or allograft. These episodes were responsive to treatment with steroids or sirolimus or both. After therapy, patients remained rejection-free on reduced immunosuppression, generally monotherapy sirolimus, despite the recovery of lymphocytes to normal levels. Conclusions. T-cell depletion alone does not induce tolerance in humans. These data underscore a prominent role for early responding monocytes in human allograft rejection. C1 NIDDKD, Transplantat & Autoimmun Branch, NIH, Bethesda, MD 20892 USA. NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. RP Kirk, AD (reprint author), Room 11S-219,Bldg 10,Ctr Dr, Bethesda, MD 20892 USA. RI Kirk, Allan/B-6905-2012; OI Kleiner, David/0000-0003-3442-4453 NR 30 TC 293 Z9 304 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD JUL 15 PY 2003 VL 76 IS 1 BP 120 EP 129 DI 10.1097/01.TP.0000071362.99021.D9 PG 10 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 703BW UT WOS:000184261000021 PM 12865797 ER PT J AU Ryan, PR Arana, BA Ryan, JR Wirtz, RA Wortmann, GW Rizzo, NR AF Ryan, PR Arana, BA Ryan, JR Wirtz, RA Wortmann, GW Rizzo, NR TI The domestic dog, a potential reservoir for Leishmania in the Peten Region of Guatemala SO VETERINARY PARASITOLOGY LA English DT Article DE Canis familiaris; Leishmania; dog; leishmaniasis; reservoir; histopathology; serology; fluorogenic PCR ID CUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS; BRAZILIENSIS; MEXICANA; PCR AB In the present study, domestic dogs in a Leishmania endemic area in the Peten Region of Guatemala were sampled to determine if they are a potential reservoir for Leishmania parasites. Blood from 100 dogs from six villages was tested with two different antibody-capture assays for Leishmania-specific antibodies and a 28% seroprevalence was determined. Tissue scrapings from six dogs presenting with chronic lesions characteristic of Leishmania infection were sampled and four dogs were positive by a genus-specific fluorogenic PCR assay. Histopathology by giemsa stain confirmed the presence of amastigotes in one of these dogs. These findings support the hypothesis that dogs may play an important role in the transmission of Leishmania in a region where no mammal has ever been implicated as a reservoir. (C) 2003 Elsevier Science B.V. All rights reserved. C1 Univ Georgia, Coll Vet Med, Athens, GA 30602 USA. Univ Valle Guatemala, Guatemala City, Guatemala. Ctr Dis Control & Prevent, Div Parasit Dis, Entomol Branch, Atlanta, GA USA. Walter Reed Army Med Ctr, Div Infect Dis, Washington, DC USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. RP Ryan, JR (reprint author), 120 Beth Court, Athens, GA 30605 USA. NR 22 TC 13 Z9 13 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-4017 J9 VET PARASITOL JI Vet. Parasitol. PD JUL 10 PY 2003 VL 115 IS 1 BP 1 EP 7 DI 10.1016/S0304-4017(03)00158-4 PG 7 WC Parasitology; Veterinary Sciences SC Parasitology; Veterinary Sciences GA 705JF UT WOS:000184391400001 PM 12860062 ER PT J AU Levin, L Munger, K Ascherio, A AF Levin, L Munger, K Ascherio, A TI Epstein-Barr virus and risk of multiple sclerosis - Reply SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. RP Levin, L (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUL 9 PY 2003 VL 290 IS 2 BP 193 EP 193 DI 10.1001/jama.290.2.193-a PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 698GH UT WOS:000183989800016 ER PT J AU Gong, P Kuperman, RG Sunahara, GI AF Gong, P Kuperman, RG Sunahara, GI TI Genotoxicity of 2,4-and 2,6-dinitrotoluene as measured by the Tradescantia micronucleus (Trad-MCN) bioassay SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS LA English DT Article DE Tradescantia; micronucleus (MCN); 2,4-dinitrotoluene; 2,6-dinitrotoluene; genotoxicity ID ECOTOXICITY CHARACTERIZATION; DINITROTOLUENES; TOXICITY AB The phytogenotoxicity of 2,4-dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) was assessed using the Tradescantia micronucleus (Trad-MCN) bioassay. Tradescantia cuttings bearing young inflorescences were exposed for 6 h to 2,4- or 2,6-DNT amended water solutions up to their respective solubilities. The nominal concentrations were 0, 1.9, 3.8, 7.5, 15, 30, 60, 100, 150, 200 mg/l of 2,4-DNT, and 0, 7.5, 15, 30, 60, 90, 120, 180 mg/l of 2,6-DNT. Each treatment was repeated three or four times. Chemical concentrations in test solutions were analyzed prior to and after the exposure. Cadmium chloride (0-20 mM) was used as the positive control. Micronuclei (MCN) were scored in the tetrad-stage pollen mother cells. The MCN frequency (%), i.e. the number of micronuclei scored in 100 tetrads, was the measurement endpoint. Results indicated that both 2,4-DNT and 2,6-DNT were genotoxic with the minimum effective dose (MED) of 30 and 135 mg/l, respectively. Longer exposure (30 h) without recovery time at 150 mg/l of 2,4-DNT and 180 mg/l of 2,6-DNT did not induce significantly higher MCN frequencies. Crown Copyright (C) 2003 Published by Elsevier Science B.V. All rights reserved. C1 Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Sunahara, GI (reprint author), Natl Res Council Canada, Biotechnol Res Inst, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada. RI Kuperman, Roman/D-4297-2009; OI Kuperman, Roman/0000-0001-5344-1633 NR 17 TC 18 Z9 21 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1383-5718 J9 MUTAT RES-GEN TOX EN JI Mutat. Res. Genet. Toxicol. Environ. Mutagen. PD JUL 8 PY 2003 VL 538 IS 1-2 BP 13 EP 18 DI 10.1016/S1383-5718(03)00089-5 PG 6 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology GA 698XR UT WOS:000184025900002 PM 12834750 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determinations of tetraethynylgermane SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; tetraethynylgermane ID DENSITY; SPECTRA AB The normal mode frequencies and corresponding vibrational assignments of Ge(CCH)(4) are examined theoretically using the GAUSSIAN 98 set of quantum chemistry codes. Each of the vibrational modes was assigned to one of six types of motion predicted by a group theoretical analysis (Ge-C stretch, Cequivalent toC stretch, C-H stretch, Cequivalent toC-H bend, Ge-Cequivalent toC bend, and C-Ge-C bend) utilizing the T-d symmetry of the molecule. A set of uniform scaling factors were derived for each type of motion. Predicted infrared and Raman intensities are reported. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSSB RRT DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSSB RRT DP, Aberdeen Proving Ground, MD 21010 USA. NR 18 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD JUL 4 PY 2003 VL 629 BP 27 EP 36 DI 10.1016/S0166-1280(03)00018-6 PG 10 WC Chemistry, Physical SC Chemistry GA 714CT UT WOS:000184895300005 ER PT J AU Arakawa, T Tsuboi, T Kishimoto, A Sattabongkot, J Suwanabun, N Rungruang, T Matsumoto, Y Tsuji, N Hisaeda, H Stowers, A Shimabukuro, I Sato, Y Torii, M AF Arakawa, T Tsuboi, T Kishimoto, A Sattabongkot, J Suwanabun, N Rungruang, T Matsumoto, Y Tsuji, N Hisaeda, H Stowers, A Shimabukuro, I Sato, Y Torii, M TI Serum antibodies induced by intranasal immunization of mice with Plasmodium vivax Pvs25 co-administered with cholera toxin completely block parasite transmission to mosquitoes SO VACCINE LA English DT Article DE vaccine; malaria; mucosal ID B-SUBUNIT; VACCINE CANDIDATES; MUCOSAL ADJUVANT; TARGET ANTIGEN; MALARIA; FALCIPARUM; PFS25; EXPRESSION; EPITOPES; PROTEINS AB Transmission-bloc king vaccines (TBVs) targeting ookinete surface proteins expressed on sexual-stage malaria parasites are considered one promising strategy for malaria control. To evaluate the prospect of developing non-invasive and easy-to-administer mucosal malaria transmission-blocking vaccines, mice were immunized intranasally with a Plasmodium vivax ookinete surface protein, Pvs25 with a mucosal adjuvant cholera toxin (CT). Immunization induced significant serum IgG with high IgG1IgG2a ratio (indicative of Th-2 type immune response). Feeding Anopheles dirus mosquitoes with mixtures of immune sera and gametocyternic blood derived from vivax-infected volunteer patients in Thailand significantly reduced both the number of midgut oocysts as well as the percentage of infected mosquitoes. The observed transmission-blocking effect was dependent on immune sera dilution. This study demonstrates for the first time that the mucosally induced mouse immune sera against a human malaria ookinete surface protein can completely block parasite transmission to vector mosquitoes, suggesting the possibility of non-invasive mucosal vaccines against mucosa-unrelated important pathogens like malaria. (C) 2003 Elsevier Science Ltd. All rights reserved. C1 Univ Ryukyus, Div Mol Microbiol, Ctr Mol Biosci, Nishihara, Okinawa 9030213, Japan. Ehime Univ, Dept Mol Parasitol, Sch Med, Shigenobu, Ehime 7910295, Japan. Ryukoku Univ, Dept Bioprod, Sch Agr, Nishihara, Okinawa 9030213, Japan. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Univ Tokyo, Lab Global Anim Resource Sci, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo 1138657, Japan. Natl Agr Res Org, Lab Parasit Dis, Natl Inst Anim Hlth, Tsukuba, Ibaraki 3050856, Japan. Univ Tokushima, Dept Immunol & Parasitol, Sch Med, Tokushima 7708503, Japan. NIAID, Parasit Dis Lab, Malaria Vaccine Dev Unit, NIH, Rockville, MD 20852 USA. Univ Ryukyus, Dept Parasitol, Sch Med, Nishihara, Okinawa 9030215, Japan. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, 3 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan. NR 24 TC 35 Z9 37 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 4 PY 2003 VL 21 IS 23 BP 3143 EP 3148 DI 10.1016/S02640410X(03)00258-5 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 699EP UT WOS:000184043200008 PM 12804841 ER PT J AU Opsenica, R Angelovski, G Pocsfalvi, G Juranic, Z Zizak, Z Kyle, D Milhous, WK Solaja, BA AF Opsenica, R Angelovski, G Pocsfalvi, G Juranic, Z Zizak, Z Kyle, D Milhous, WK Solaja, BA TI Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article ID DIHYDROARTEMISININ DERIVATIVES; DISPIRO-1,2,4,5-TETRAOXANES; 1,2,4,5-TETRAOXANES; RESISTANCE; INVITRO AB Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei). (C) 2003 Elsevier Science Ltd. All rights reserved. C1 Univ Belgrade, Fac Chem, YU-11001 Belgrade, Serbia Monteneg. Inst Chem Technol & Met, Belgrade, Serbia Monteneg. CNR, Ist Sci Alimentazione, Ctr Spettrometria Massa Prot & Biomol, Avellino, Italy. Natl Canc Res Inst, Belgrade, Serbia Monteneg. Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 158, YU-11001 Belgrade, Serbia Monteneg. EM bsolaja@chem.bg.ac.yu RI Pocsfalvi, Gabriella/K-3753-2013; Pocsfalvi, Gabriella/C-4948-2015; OI Pocsfalvi, Gabriella/0000-0001-6065-3853; Solaja, Bogdan/0000-0002-9975-2725 NR 21 TC 5 Z9 5 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 EI 1464-3391 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD JUL 3 PY 2003 VL 11 IS 13 BP 2761 EP 2768 DI 10.1016/S0968-0896(03)00224-4 PG 8 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 691DT UT WOS:000183590100011 ER PT J AU Cheruku, SR Maiti, S Dorn, A Scorneaux, B Bhattacharjee, AK Ellis, WY Vennerstrom, JL AF Cheruku, SR Maiti, S Dorn, A Scorneaux, B Bhattacharjee, AK Ellis, WY Vennerstrom, JL TI Carbon isosteres of the 4-aminopyridine substructure of chloroquine: Effects on pK(a), hematin binding, inhibition of hemozoin formation, and parasite growth SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID BETA-HEMATIN; QUINOLINE ANTIMALARIALS; FERRIPROTOPORPHYRIN-IX; MALARIA PARASITES; AQUEOUS-SOLUTION; POLYMERIZATION; MECHANISM; RESISTANCE; COMPLEXES; PROTEIN AB Unlike diprotic chloroquine (CQ), its two 4-aminoquinoline carbon isosteres (1, 2) are monoprotic at physiological pH. Compared to CQ, hematin binding affinity of 1 decreased 6.4-fold, and there was no measurable binding for 2. Although 1 was a weak inhibitor of hemozoin formation, neither isostere inhibited P. falciparum in vitro. Evidently, the CQ-hematin interaction is largely a function of its pyridine substructure, but inhibition of hemozoin formation and parasite growth depends on its 4-aminopyridine substructure. C1 Univ Nebraska, Coll Pharm, Med Ctr, Omaha, NE 68198 USA. F Hoffmann La Roche & Co Ltd, Div Pharma, CH-4070 Basel, Switzerland. Swiss Trop Inst, CH-4002 Basel, Switzerland. Walter Reed Army Med Ctr, Div Expt Therapeut, Washington, DC 20307 USA. RP Vennerstrom, JL (reprint author), Univ Nebraska, Coll Pharm, Med Ctr, 986025 Nebraska Med Ctr, Omaha, NE 68198 USA. EM jvenners@unmc.edu NR 34 TC 41 Z9 41 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUL 3 PY 2003 VL 46 IS 14 BP 3166 EP 3169 DI 10.1021/jm030038x PG 4 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 695HF UT WOS:000183824500034 PM 12825955 ER PT J AU Hartzell, JD Oster, CN Gaydos, JC AF Hartzell, JD Oster, CN Gaydos, JC TI How contagious are common respiratory tract infections? SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID EPIDEMIC; DISEASE C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. US Dept Def, Global Emerging Infect Surveillance Syst, Silver Spring, MD 20910 USA. RP Hartzell, JD (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 5 TC 1 Z9 1 U1 1 U2 4 PU MASSACHUSETTS MEDICAL SOC/NEJM PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 3 PY 2003 VL 349 IS 1 BP 95 EP 95 DI 10.1056/NEJMc031032 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 696PW UT WOS:000183896100029 PM 12840101 ER PT J AU Muench, SP Rafferty, JB Mcleod, R Rice, DW Prigge, ST AF Muench, SP Rafferty, JB Mcleod, R Rice, DW Prigge, ST TI Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase SO ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY LA English DT Article ID CARRIER PROTEIN REDUCTASE; X-RAY-STRUCTURE; ESCHERICHIA-COLI; ACP REDUCTASE; TRICLOSAN ACTIVITY; MOLECULAR-BASIS; DETERMINANTS; SYNTHASE; MALARIA AB New hope has been gained in the control of the malaria parasite Plasmodium falciparum (pf) with the discovery that the parasite contains a prokaryotic type II fatty-acid synthase (FAS). Since enzymes of this type are absent in humans, they are potential targets for the development of new drugs. The enoyl reductase enzyme (ENR) belonging to this pathway is of particular interest because it has been shown to be inhibited by submicromolar concentrations of the antimicrobial agent triclosan. Here, the development of an efficient overexpression system for pfENR as a fusion protein with maltose-binding protein, its simple one-step purification and cleavage from its fusion protein and crystallization under new conditions with bound NAD(+) cofactor and triclosan are reported. The crystals belong to the space group P2(1), with approximate unit-cell parameters a = 88.2, b = 82.4, c = 94.8 Angstrom, beta = 90.77degrees, and contain a tetramer in the asymmetric unit. Cryocooled crystals (100 K) diffracted to beyond 2.2 Angstrom resolution at the Daresbury Synchrotron Radiation Source. C1 Johns Hopkins Bloomberg Sch Publ Hlth, Malaria Res Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. Univ Chicago, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA. Univ Sheffield, Krebs Inst Biomol Res, Dept Mol Biol & Biotechnol, Sheffield S10 2TN, S Yorkshire, England. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Prigge, ST (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Malaria Res Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. OI Rafferty, John/0000-0003-1183-7474; Muench, Stephen/0000-0001-6869-4414 NR 19 TC 20 Z9 20 U1 0 U2 0 PU BLACKWELL MUNKSGAARD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0907-4449 J9 ACTA CRYSTALLOGR D JI Acta Crystallogr. Sect. D-Biol. Crystallogr. PD JUL PY 2003 VL 59 BP 1246 EP 1248 DI 10.1107/S0907444903008813 PN 7 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography SC Biochemistry & Molecular Biology; Biophysics; Crystallography GA 695AX UT WOS:000183809900022 PM 12832774 ER PT J AU Tovanabutra, S Watanaveeradej, V Viputtikul, K De Souza, M Razak, MH Suriyanon, V Jittiwutikarn, J Sriplienchan, S Nitayaphan, S Benenson, MW Sirisopana, N Renzullo, PO Brown, AE Robb, ML Beyrer, C Celentano, DD McNeil, JG Birx, DL Carr, JK McCutchan, FE AF Tovanabutra, S Watanaveeradej, V Viputtikul, K De Souza, M Razak, MH Suriyanon, V Jittiwutikarn, J Sriplienchan, S Nitayaphan, S Benenson, MW Sirisopana, N Renzullo, PO Brown, AE Robb, ML Beyrer, C Celentano, DD McNeil, JG Birx, DL Carr, JK McCutchan, FE TI A new circulating recombinant form, CRF15_01B, reinforces the linkage between IDU and heterosexual epidemics in Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; INJECTING DRUG-USERS; HIV TYPE-1; SOUTHERN CHINA; CRF01-AE/B RECOMBINANT; GENETIC DIVERSITY; RECENT OUTBREAK; BC RECOMBINANT; SUBTYPE-E; STRAINS AB HIV-1 subtype B and CRF01_AE have been in circulation in Thailand and Southeast Asia for more than a decade. Initially separated by risk group, the two strains are increasingly intermixed, and two recombinant strains of essentially reciprocal structure have been recently reported. Here we identify additional CRF_01B recombinants and provide the evidence that HIV-1 strains now pass freely between the two high-risk populations. HIV isolates that showed discordance between CRF01_AE and subtype B in multi-region genotyping assays were selected for the study. They were drawn from 3 different cohorts in Thailand representing different risk behaviors and demographic characteristics: a drug user cohort in the north, a family planning clinic attendee cohort in the southeast, and a cohort study of the mucosal virology and immunology of HIV-1 infection in Thailand. The DNA from these isolates was PCR amplified to recover the full HIV-1 genome and subjected to sequencing and phylogenetic analysis. We establish that one particular CRF_01B recombinant, with the external envelope of subtype B and the rest of the genome from CRF01_AE, is circulating widely in Thailand. Termed CRF15_01B (also referred to as CRF15), the strain was primarily heterosexually transmitted,, although injecting drug use (IDU) also played a role. In aggregate data from the studies, CRF15 constituted 1.7% of all HIV-1 infections (95% confidence interval 0.5-4.4%) and was dispersed widely in the country. The previously separate heterosexual and IDU epidemics have apparently been bridged by a new CRF. The entry of CRF15 into the mainstream of the epidemic signals new complexity in the long stable molecular picture in Thailand. These recombinants must be considered in ongoing or projected efficacy evaluations of HIV-1 vaccines and antiviral therapies. C1 Henry M Jackson Fdn, Rockville, MD 20850 USA. Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. Armed Forces Res Inst Med Sci, Royal Thai Army Component, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, Henry M Jackson Fdn, Bangkok 10400, Thailand. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. Chiang Mai Univ, Fac Med, Chiang Mai 50000, Thailand. No Drug Dependence Treatment Ctr, Chiang Mai, Thailand. Pramongkutklao Hosp Sch Med, Dept Pediat, Bangkok, Thailand. Armed Forces Res Inst Med Sci, USA Med Component, Bangkok 10400, Thailand. Walter Reed Army Inst Res, Rockville, MD 20850 USA. RP Tovanabutra, S (reprint author), Henry M Jackson Fdn, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. FU NIDA NIH HHS [1 R01 DA 11133] NR 32 TC 81 Z9 88 U1 1 U2 6 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JUL PY 2003 VL 19 IS 7 BP 561 EP 567 DI 10.1089/088922203322230923 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 705NL UT WOS:000184401100004 PM 12908933 ER PT J AU Cadarette, BS Levine, L Staab, JE Kolka, MA Correa, MM Whipple, M Sawka, MN AF Cadarette, BS Levine, L Staab, JE Kolka, MA Correa, MM Whipple, M Sawka, MN TI Upper body cooling during exercise-heat stress wearing the improved toxicological agent protective system for HAZMAT operations SO AIHA JOURNAL LA English DT Article DE exercise; HAZMAT; heat stress; human physiology; PPE; toxic environments ID THERMAL ENVIRONMENTS; ENSEMBLES; STRAIN; WORK AB This study compared endurance in a U.S. Army developmental Occupational Safety and Health Administration Level B personal protective equipment (PPE) system against the toxicological agent protective (TAP) suit, the Army's former standard PPE for Level A and Level B toxic environments. The developmental system consisted of two variations: the improved toxicological agent protective (ITAP) suit with self-contained breathing apparatus (ITAP-SCBA), weight 32 kg, and the ITAP with blower (ITAP-B), weight 21 kg. Both ITAP suits included the personal ice cooling system (PICS). TAP (weight 9.5 kg) had no cooling. It was hypothesized that PICS would effectively cool both ITAP configurations, and endurance in TAP would be limited by heat strain. Eight subjects (six men, two women) attempted three 2-hour treadmill walks (0.89 m/sec, 0% grade, rest/exercise cycles of 10/20 min) at 38degreesC, 30% relative humidity Metabolic rate for TAP (222+/-35 W) was significantly less than either ITAP-SCBA (278+/-27 W) or ITAP-B (262+/-24 W) (p<0.05). Endurance time was longer in ITAP-SCBA (85+/-20 min) and ITAP-B (87+/-25 min) than in TAP (46+/-10 min) (p<0.05). Heat storage was greater in TAP (77+/-15 W.m(-2)) than in ITAP-SCBA (51+/-16 W.m(-2)) (p<0.05), which was not different from ITAP-B (59+/-14 W.m(-2)). Sweating rate was greater in TAP (23.5+/-11.7 g/min(1)) than in either ITAP-SCBA (11.1+/-2.9 g/min) or ITAP-B (12.8+/-3.5 g/min) (p<0.05). Endurance in ITAP was nearly twice as long as in PPE with no cooling, even though the PICS, SCBA tanks, and new uniform itself all served to increase metabolic cost over that in TAR PICS could also be used with civilian Levels A and B PPE increasing work time and worker safety. C1 USA, Res Inst Environm Med, Natick, MA 01760 USA. USA, Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Cadarette, BS (reprint author), USA, Res Inst Environm Med, Kansas St, Natick, MA 01760 USA. NR 20 TC 5 Z9 5 U1 0 U2 1 PU AMER INDUSTRIAL HYGIENE ASSOC PI FAIRFAX PA 2700 PROSPERITY AVE #250, FAIRFAX, VA 22031-4307 USA SN 1529-8663 J9 AIHA J JI AIHA J. PD JUL-AUG PY 2003 VL 64 IS 4 BP 510 EP 515 DI 10.1080/15428110308984847 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 711CQ UT WOS:000184722000014 PM 12908867 ER PT J AU Lettieri, CJ Berg, BW AF Lettieri, CJ Berg, BW TI Clinical features of non-Hodgkins lymphoma presenting with acute liver failure: A report of five cases and review of published experience SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID FULMINANT HEPATIC-FAILURE; INFILTRATION; SECONDARY; DISEASE AB Hematological malignancies frequently affect the liver, but typically do not result in hepatic dysfunction and rarely present with advanced hepatic involvement. We report five patients who presented with advanced hepatic involvement and were found to have a high-grade lymphoma infiltrating the liver. Despite early diagnosis and initiation of therapy, all five patients deteriorated rapidly and died shortly after the onset of liver failure. Several similar cases have been reported. They share common clinical features, including hepatomegaly, lactic acidosis, and death shortly after the onset of symptoms. Non-Hodgkins lymphoma is a common malignancy, which is increasing in incidence. Non- Hodgkins lymphoma is not commonly entertained as an etiology of advanced liver failure and is likely underrecognized. In cases of acute advanced liver failure without an apparent etiology, especially if associated with hepatomegaly and lactic acidosis, lymphoma should be considered because of its poor prognosis and potential for treatment if recognized early. Liver biopsy is an invaluable tool that provides an early diagnosis while excluding other potential etiologies for acute advanced liver failure. (C) 2003 by Am. Coll. of Gastroenterology. C1 Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. Walter Reed Army Med Ctr, Dept Med, Pulm Crit Care Serv, Washington, DC 20307 USA. RP Berg, BW (reprint author), Tripler Army Med Ctr, Dept Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 23 TC 25 Z9 28 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JUL PY 2003 VL 98 IS 7 BP 1641 EP 1646 DI 10.1016/S0002-9270(03)00365-4 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 702GP UT WOS:000184216400032 PM 12873593 ER PT J AU Abbott, KC Reynolds, JC Cruess, DF Agodoa, LY AF Abbott, KC Reynolds, JC Cruess, DF Agodoa, LY TI Morning versus evening hemodialysis - In reply SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Letter C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Washington, DC USA. NIDDK, NIH, Bethesda, MD USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD JUL PY 2003 VL 42 IS 1 BP 213 EP 213 AR E1 DI 10.1016/S0272-6386(03)00559-6 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 696MK UT WOS:000183890500029 ER PT J AU Zahn, CM Gonzalez, DI Suto, C Kennedy, S Hines, JF AF Zahn, CM Gonzalez, DI Suto, C Kennedy, S Hines, JF TI Low-dose oral contraceptive effocts on thromboelastogram criteria and relationship to hypercoagulability SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE low-dose oral contraceptives; thromboelastography; hypercoagulability ID VENOUS THROMBOEMBOLISM; FOLLOW-UP; RISK; COAGULATION; THROMBELASTOGRAPHY; COMPONENTS; DISEASE AB OBJECTIVE: The study was undertaken to assess hypercoagulability, by using thromboelastography, in women who use low-dose oral contraceptives (OCs). STUDY DESIGN: Forty-three women using low-dose OCs (less than or equal to 35 mug ethinyl estradiol) underwent thromboelastography before starting OCs and again during the third month of OC use. Prior and 3-month mean values of four thromboelastogram parameters (maximum amplitude [MA], K time, alpha angle, and R time) were compared by using paired t tests. Comparison according to progestin type was also performed with unpaired t tests. RESULTS: Prior versus 3-month values for MA, a, and K were not significantly different (P values-K: 0.8; alpha: .34; MA: 0.49); power was adequate to detect small differences. The 3-month R time was decreased compared with pre-OC values (P = .025), although the magnitude of this change was not characteristic of hypercoagulability. Comparison according to progestin type demonstrated no difference. CONCLUSION: We found no significant trend toward hypercoagulability in women who used low-dose OCs and who otherwise had no known thromboembolic risks. C1 Wilford Hall USAF Med Ctr, Dept Obstet & Gynecol, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Dept Obstet & Gynecol, San Antonio, TX USA. RP Zahn, CM (reprint author), Wilford Hall USAF Med Ctr, Dept Obstet & Gynecol, San Antonio, TX 78236 USA. NR 25 TC 6 Z9 7 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUL PY 2003 VL 189 IS 1 BP 43 EP 47 DI 10.1067/mob.2003.344 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 703TE UT WOS:000184296400008 PM 12861136 ER PT J AU Wright, TC Cox, JT Massad, LS Carlson, J Twiggs, LB Wilkinson, EJ AF Wright, TC Cox, JT Massad, LS Carlson, J Twiggs, LB Wilkinson, EJ CA 2001 ASCCP sponsored Consensus Worsh TI 2001 Consensus Guidelines for the Management of Women with Cervical Intraepithelial Neoplasia SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Review DE cervical intraepithelial neoplasia; LEEP; colposcopy ID COLD-KNIFE CONIZATION; LOOP ELECTROSURGICAL EXCISION; HISTOLOGICAL INCOMPLETE EXCISION; HUMAN-PAPILLOMAVIRUS INFECTION; HUMAN-IMMUNODEFICIENCY-VIRUS; FOLLOW-UP; RANDOMIZED TRIAL; NATURAL-HISTORY; UTERINE CERVIX; CONSERVATIVE MANAGEMENT AB OBJECTIVE: The study was undertaken to provide consensus guidelines for the management of women with histologically confirmed cervical intraepithelial neoplasia (CIN) that can act as a precursor to invasive cervical cancer and represents one of the most common significant gynecologic diseases of women of reproductive age. PARTICIPANTS: An independent panel of 121 experts in various aspects of the diagnosis and management of cervical cancer precursors, including representatives from 29 participating professional organizations, federal agencies, national and international health organizations, and others Were invited by the American Society for Colposcopy and Cervical Pathology (ASCCP). CONSENSUS PROCESS: Guidelines for the management of women with CIN were developed through a multistep process. Draft management guidelines were developed by working groups who performed formal literature reviews and obtained input from the professional community at large by way of an interactive internet-based bulletin board. At the ASCCP Consensus Conference, September 6 through 8, 2001, in Bethesda, Md, all guidelines were discussed, revised, and adopted by formal vote. CONCLUSION: Evidence-based guidelines have been developed for the management of women with biopsy-confirmed CIN. C1 Columbia Univ, Dept Pathol, Coll Phys & Surg, New York, NY USA. Univ Calif Santa Barbara, Student Hlth Serv, Santa Barbara, CA 93106 USA. Amer Social Hlth Assoc, Durham, NC USA. So Illinois Univ, Sch Med, Dept Obstet & Gynecol, Springfield, IL 62794 USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. Univ Miami, Inst Womens Hlth, Miami, FL 33152 USA. Univ Florida, Dept Pathol, Gainesville, FL 32611 USA. RP Wright, TC (reprint author), Room 16-404,P&S Bldg,630 W 168th St, New York, NY 10032 USA. EM tcw1@columbia.edu FU NCI NIH HHS [1 R13 CA96190-01] NR 90 TC 174 Z9 205 U1 0 U2 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUL PY 2003 VL 189 IS 1 BP 295 EP 304 DI 10.1067/mob.2003.633 PG 10 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 703TE UT WOS:000184296400050 PM 12861176 ER PT J AU O'Boyle, AL Davis, GD Calhoun, BC AF O'Boyle, AL Davis, GD Calhoun, BC TI Clarifying the meaning of vaginal birth - Reply SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Letter C1 Madigan Army Med Ctr, Div Urogynecol, Tacoma, WA 98431 USA. Walter Reed Army Med Ctr, Div Urogynecol, Washington, DC 20307 USA. Rockford Mem Med Ctr, Div Maternal Fetal Med, Rockford, IL 61103 USA. RP O'Boyle, AL (reprint author), Madigan Army Med Ctr, Div Urogynecol, 9040A Fitzsimmons Dr, Tacoma, WA 98431 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 EI 1097-6868 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUL PY 2003 VL 189 IS 1 BP 308 EP 308 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 703TE UT WOS:000184296400059 ER PT J AU Ruess, L O'Connor, SC Cho, KH Hussain, FH Howard, WJ Slaughter, RC Hedge, A AF Ruess, L O'Connor, SC Cho, KH Hussain, FH Howard, WJ Slaughter, RC Hedge, A TI Carpal tunnel syndrome and cubital tunnel syndrome: Work-related musculoskeletal disorders in four symptomatic radiologists SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article; Proceedings Paper CT 101st Annual Meeting of the American-Roentgen-Ray-Society CY APR 29-MAY 04, 2001 CL SEATTLE, WASHINGTON SP Amer Roentgen Ray Soc ID REST BREAKS; PRODUCTIVITY; USERS AB OBJECTIVE. This report describes work-related upper extremity musculoskeletal disorders in four radiologists and identifies risk factors and preventive measures for these syndromes. SUBJECTS AND METHODS. Four radiologists with complaints of upper extremity pain, numbness, and weakness or a combination of symptoms were examined by an occupational therapist. The work activities and duties of all 12 staff radiologists in our filmless department were subsequently evaluated. Time working as staff, workday hours, and academic activities were recorded. Nonoccupational activities were also noted. An industrial hygienist evaluated the department work areas and staff offices. RESULTS. One radiologist had bilateral carpal tunnel syndrome, and all four radiologists had cubital tunnel syndrome (two [50%] unilateral, two [50%] bilateral). The four spent 3.4 +/- 0.3 years (mean standard error of the mean) as staff radiologists in our filmless department, performing computer keyboard and mouse or trackball image manipulation and work list navigation, typing preliminary reports and telephone notifications, and editing electronically and approving dictated final reports. All four are academically active and had significantly greater workday hours (p < 0.05) and performed more research (p < 0.003) than the asymptomatic radiologists. Three (75%) of four radiologists routinely performed sonography. The industrial hygienist identified hazardous working conditions, especially related to ergonomics, in the reviewing areas and staff offices. CONCLUSION. Current technology renders staff radiologists at risk for work-related, upper extremity musculoskeletal disorders, including carpal and cubital tunnel syndromes. Proper equipment, ergonomics, and professional consultation should be used in all radiology departments. C1 Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Pediat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. Tripler Army Med Ctr, Dept Occupat Therapy, Honolulu, HI 96859 USA. Cornell Univ, Dept Design & Environm Anal, Human Factors & Ergon Lab, Ithaca, NY 14853 USA. RP Ruess, L (reprint author), Tripler Army Med Ctr, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 21 TC 26 Z9 26 U1 0 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUL PY 2003 VL 181 IS 1 BP 37 EP 42 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 692DG UT WOS:000183644800008 PM 12818826 ER PT J AU Wongsrichanalai, C Arevalo, I Laoboonchai, A Yingyuen, K Miller, RS Magill, AJ Forney, JR Gasser, RA AF Wongsrichanalai, C Arevalo, I Laoboonchai, A Yingyuen, K Miller, RS Magill, AJ Forney, JR Gasser, RA TI Rapid diagnostic devices for malaria: Field evaluation of a new prototype immunochromatographic assay for the detection of Plasmodium falciparum and non-Falciparum plasmodium SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CLINICAL-DIAGNOSIS; EXPERT MICROSCOPY; TESTS; VIVAX; THAILAND; P.F/P.V; PANMALARIAL; INDONESIA; ACCURACY; AREA AB The NOW(R) ICT Malaria P.f./P.v. for Whole Blood (Binax, Inc., Portland, ME) is a new malaria rapid diagnostic device that represents a technical advance over previous assays, such as ICT(TM) Malaria P.f./P.v. and ICT(TM) Malaria P.f.. We evaluated this device in March 2001 in symptomatic patients at malaria clinics in Maesod, Thailand. Microscopic examination of Giemsa-stained blood smears was the reference standard. In 246 patients, microscopy showed 32 (13.0%) infected with Plasmodium falciparum, 63 (25.6%) with P. vivax, 6 (2.4%) with mixed infections of P. falciparum and P. vivax, 5 (2.0%) with P. malariae, and 140 (56.9%) negative. Sensitivity for P. falciparum was 100% and specificity was 96.2% (200 of 208; 95% confidence interval [CI] = 92-98). For P. vivax, sensitivity was 87.3% (55 of 63; 95% CI = 77-93) and specificity was 97.7% (173 of 177; 95% CI = 95-99), but all the four false-positive results were microscopically positive for P. malariae; thus, specificity for non-falciparum Plasmodium was 100%. These results suggest improved performance over NOW(R) ICT predecessors. C1 Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. US Mil Acad, W Point, NY 10996 USA. RP Wongsrichanalai, C (reprint author), USN, Med Res Unit 2, Kompleks P2M PLP LITBANGKES,Jalan Percetakan 29, Jakarta 10570, Indonesia. NR 22 TC 30 Z9 32 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2003 VL 69 IS 1 BP 26 EP 30 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 706WC UT WOS:000184477200007 PM 12932092 ER PT J AU Swiecki, C Stojadinovic, A Anderson, J Zhao, AP Dawson, H Shea-Donohue, T AF Swiecki, C Stojadinovic, A Anderson, J Zhao, AP Dawson, H Shea-Donohue, T TI Effect of hyperglycemia and nitric oxide synthase inhibition on heat tolerance and induction of heat shock protein 72KDa in vivo SO AMERICAN SURGEON LA English DT Article ID ISCHEMIA-REPERFUSION; EXPRESSION; INJURY; RAT; HSP70; HEAT-SHOCK-PROTEIN-70; INFLAMMATION; PROTECTION; DAMAGE; CELLS AB Diabetes and nitric oxide synthase (NOS) inhibition both exacerbate mesenteric ischemia/reperfusion injury. Heat shock protein 72 (HSP-72) protects against kappaDa ischemia/reperfusion damage in vivo. The effect of diabetes on HSP-72 expression in vivo is unknown. The aim of this study was to determine the effects of diabetes and NOS inhibition on HSP-72 induction in vivo. Rats were assigned to four groups: control (C), streptozotocin-induced diabetic (D), acute hyperglycemia (A), and L-N-omega-nitro-L-arginine treated (L). Rats were subjected to hyperthermia and allowed to recover for 4 hours. Intestine and liver samples from heated (H) and nonheated (NH) rats were analyzed for HSP-72 by Western blot. HSP-72 levels were increased significantly in CH compared to CNH rats. No deaths occurred in CH rats; however, death rates were significant in AH, DH, and LH rats. DH rats died earlier than LH and AH rats. HSP-72 in liver and intestine was reduced significantly in LH rats. When compared with CH rats the surviving AH and DH rats exhibited similar HSP-72 levels in the liver. Diabetes, acute hyperglycemia, and L-N-omega-nitro-L-arginine treatment lower heat stress tolerance. NOS is required for HSP-72 expression, but not survival. Diabetics who survive heat stress moderately express HSP-72. Characterization of altered thermotolerance and HSP-72 may provide mechanisms for the deranged diabetic stress response. C1 USDA ARS, NRFL, BARC E, Beltsville, MD 20705 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Shea-Donohue, T (reprint author), USDA ARS, NRFL, BARC E, 10300 Baltimore Ave, Beltsville, MD 20705 USA. RI Dawson, Harry/H-8242-2013 NR 21 TC 10 Z9 10 U1 0 U2 2 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD JUL PY 2003 VL 69 IS 7 BP 587 EP 592 PG 6 WC Surgery SC Surgery GA 700WN UT WOS:000184134300011 PM 12889622 ER PT J AU Danforth, DN Cowan, K Altemus, R Merino, M Chow, C Berman, A Chaudhry, U Shriver, C Steinberg, SM Zujewski, J AF Danforth, DN Cowan, K Altemus, R Merino, M Chow, C Berman, A Chaudhry, U Shriver, C Steinberg, SM Zujewski, J TI Preoperative FLAC/granulocyte-colony-stimulating factor chemotherapy for stage II breast cancer: A prospective randomized trial SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE breast cancer; preoperative chemotherapy; neoadjuvant; breast conservation; axillary lymph nodes ID NEOADJUVANT CHEMOTHERAPY; CHEMOENDOCRINE THERAPY; LEUCOVORIN; SURVIVAL; DISEASE; SURGERY; TUMORS; WOMEN AB Background: Preoperative chemotherapy for stage II breast cancer may reduce locoregional tumors and provides initial treatment for systemic micrometastases. We conducted a prospective, randomized trial to evaluate the ability of intensive preoperative chemotherapy to enhance the outcome of this approach. Methods: Patients with clinical stage II breast cancer (T2N0, T1N1, and T2N1) were prospectively randomized to receive either preoperative or postoperative chemotherapy with five 21-day cycles of fluorouracil, leucovorin calcium, doxorubicin, and cyclophosphamide (FLAC)/granulocyte-colony-stimulating factor. Local therapy consisted of modified radical mastectomy or segmentectomy/axillary dissection/breast radiotherapy, according to patient preference. Results: Fifty-three women were randomized (26 preoperative chemotherapy and 27 postoperative chemotherapy). The objective clinical response rate of the primary tumor to preoperative chemotherapy was 80%, and the pathologic complete response rate was 20%. Preoperative chemotherapy reduced the overall incidence and number of axillary lymph node metastases. There was no difference in the use of breast-conserving local therapy between the two treatment arms. There were 20 local/regional or distant recurrences (9 preoperative and 11 postoperative). There was no difference in the overall or disease-free survival between the preoperative and postoperative chemotherapy arms. Conclusions: Preoperative FLAC/granulocyte-colony-stimulating factor chemotherapy was effective against local/regional tumors in stage II breast cancer but was otherwise comparable to postoperative chemotherapy. C1 NCI, Surg Branch, Ctr Canc Res, Bethesda, MD 20815 USA. NCI, Med Branch, Ctr Canc Res, Bethesda, MD 20815 USA. NCI, Radiat Oncol Branch, Ctr Canc Res, Bethesda, MD 20815 USA. NCI, Pathol Lab, Ctr Canc Res, Bethesda, MD 20815 USA. NCI, Biostat & Data Management Sect, Ctr Canc Res, Bethesda, MD 20815 USA. NIH, Dept Radiol, Ctr Clin, Bethesda, MD 20892 USA. NIH, Dept Rehabil Med, Ctr Clin, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP NCI, Surg Branch, Ctr Canc Res, Bldg 10,Rm 2B38, Bethesda, MD 20815 USA. EM david_danforth@nih.gov NR 29 TC 14 Z9 17 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 EI 1534-4681 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD JUL PY 2003 VL 10 IS 6 BP 635 EP 644 DI 10.1245/ASO.2003.12.008 PG 10 WC Oncology; Surgery SC Oncology; Surgery GA 698AJ UT WOS:000183975200009 PM 12839848 ER PT J AU Happi, TC Thomas, SM Gbotosho, GO Falade, CO Akinboye, DO Gerena, L Hudson, T Sowunmi, A Kyle, DE Milhous, W Wirth, DF Oduola, AMJ AF Happi, TC Thomas, SM Gbotosho, GO Falade, CO Akinboye, DO Gerena, L Hudson, T Sowunmi, A Kyle, DE Milhous, W Wirth, DF Oduola, AMJ TI Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID MULTIDRUG-RESISTANCE GENE; TREATMENT FAILURES; MOLECULAR MARKER; IN-VITRO; POLYMORPHISMS; THAILAND; AMPLIFICATION; TRANSPORTER; INFECTIONS; PROTEIN AB Chloroquine (CQ) resistance in Plasmodium falciparum has been associated with specific point mutations in the pfcrt and pfmdr-1 genes. In the present study, 30 children aged 1-12 years, who were all suffering from acute, uncomplicated, P. falciparum malaria in Ibadan, Nigeria, were evaluated to assess the association between these mutations and clinical outcome following treatment with CQ. The parasites, in blood samples collected pretreatment and, in those who failed treatment, on the day symptoms re-occurred post-treatment, were genotyped using the polymorphic MSP1, MSP2 and GLURP loci and PCR RFLP. The results showed that, pre-treatment, all 30 patients had polyclonal infections, the mean numbers of P. falciparum clones detected per infection being 2.6 with MSPI, 4.2 with MSP2 and 2.8 with GLURP. The T76 allele of pfcrt and the Y86 allele of pfmdr-1 were found in 53% and 40%, respectively, of the pre-treatment samples from the 15 patients who failed CQ treatment, but the Y1246 mutation in pfmdr-1 was never detected. Although the parasites from the two patients with high-grade (RIII) resistance to CQ had both of these point mutations, the presence of the T76 allele of pfcrt or the Y86 allele of pfmdr-1 (considered individually) could not be used to predict treatment outcome. However, a high frequency of clonal multiplicity may confound attempts to associate the point mutations in pfcrt or pfmdr-1 with clinical response to CQ. It remains unclear whether the present results represent the characteristics of the predominant parasite populations in the study area. Further studies are needed before the strength of the association between the point mutations identified as markers of drug resistance and clinical outcome can be accurately evaluated, in this and other regions of intense transmission. C1 Univ Ibadan, Postgrad Inst Med Res & Training, Coll Med, Malaria Res Labs, Ibadan, Nigeria. Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Parasitol, Div Expt Therapeut, Washington, DC 20307 USA. WHO, Special Programme Res & Training Trop Dis, TDR, CH-1211 Geneva, Switzerland. RP Oduola, AMJ (reprint author), Univ Ibadan, Postgrad Inst Med Res & Training, Coll Med, Malaria Res Labs, Ibadan, Nigeria. RI Hudson, Thomas/A-9152-2011 NR 46 TC 32 Z9 33 U1 0 U2 1 PU MANEY PUBLISHING PI LEEDS PA HUDSON RD, LEEDS LS9 7DL, ENGLAND SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD JUL PY 2003 VL 97 IS 5 BP 439 EP 451 DI 10.1179/000349803235002489 PG 13 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA 704PK UT WOS:000184348500001 PM 12930607 ER PT J AU Taylor, WR Richie, TL Fryauff, DJ Ohrt, C Picarima, H Tang, D Murphy, GS Widjaja, H Braitman, D Tjitra, E Ganjar, A Jones, TR Basri, H Berman, J AF Taylor, WR Richie, TL Fryauff, DJ Ohrt, C Picarima, H Tang, D Murphy, GS Widjaja, H Braitman, D Tjitra, E Ganjar, A Jones, TR Basri, H Berman, J TI Tolerability of azithromycin as malaria prophylaxis in adults in northeast Papua, Indonesia SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID MYCOBACTERIUM-AVIUM COMPLEX; HUMAN-IMMUNODEFICIENCY-VIRUS; CONTROLLED TRIAL; DOSE AZITHROMYCIN; LUNG-DISEASE; DOUBLE-BLIND; SAFETY; OTOTOXICITY; DOXYCYCLINE; CHILDREN AB Drug tolerability affects compliance. We evaluated the tolerability levels of azithromycin (750-mg loading dose plus 250 mg/day; n = 148 subjects), doxycycline (100 mg/day; n = 75), and placebo (n = 77) as prophylaxis against malaria in Indonesian adults over 20 weeks. Self-reported and elicited symptoms, health perception, hearing, hematology, and biochemistry were assessed. The loading dose was well tolerated. The frequencies (number per person-years [p-yr]) of all daily reported symptoms were similar in the three arms of the study: 40.2/p-yr for azithromycin, 39.7/p-yr for doxycycline, and 38.2/p-yr for placebo. Relative to those who received placebo, azithromycin recipients complained more often of heartburn (rate ratio = 10.5 [95% confidence interval, 2.8 to 88.1]), paresthesia (2.03 [1.08 to 4.24]), and mild (1.55 [1.01 to 2.48]) and severe (11.2 [1.34 to infinity]) itching but less often of fever (0.21 [0.09 to 0.49]) and tinnitus (0.09 [0.04 to 0.21]). Azithromycin recipients showed no evidence of clinical hearing loss or hematologic, hepatic, or renal toxicity. One azithromycin recipient developed an erythematous rash. Daily azithromycin was well tolerated by these Indonesian adults during 20 weeks of treatment. C1 Dist Mil Hlth Serv, Jayapura, Papua, Indonesia. Natl Inst Hlth, Ctr Hlth Res & Dev, Jakarta, Indonesia. Natl Inst Hlth, USN Med Res Unit 2, Jakarta, Indonesia. Tulane Univ, Sch Publ Hlth, Dept Trop Med, New Orleans, LA 70118 USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Biometr, Washington, DC 20307 USA. USA, Med Mat Dev Act, Ft Detrick, MD USA. RP Taylor, WR (reprint author), WHO, TDR, PRD, Ave Appia, CH-1211 Geneva, Switzerland. RI Richie, Thomas/A-8028-2011; OI Richie, Thomas/0000-0002-2946-5456 NR 25 TC 11 Z9 12 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2003 VL 47 IS 7 BP 2199 EP 2203 DI 10.1128/AAC.47.7.2199-2203.2003 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 694RA UT WOS:000183786700021 PM 12821468 ER PT J AU Butkus, MA Bays, JT Labare, MP AF Butkus, MA Bays, JT Labare, MP TI Influence of surface characteristics on the stability of Cryptosporidium parvum oocysts SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID TRANSFORM INFRARED-SPECTROSCOPY; ELECTROPHORETIC MOBILITY; ORAL STREPTOCOCCI; WATER-SUPPLIES; GIARDIA CYSTS; FILTRATION; HYDROPHOBICITY; PARTICLES; SORPTION AB Microelectrophoresis is a common technique for probing the surface chemistry of the Cryptosporidium parvum oocyst. Results of previous studies of the electrophoretic mobility of C. parmin oocysts in which microelectrophoresis was used are incongruent. In this work we demonstrated that capillary electrophoresis may also be used to probe the surface characteristics of C parvum oocysts, and we related the surface chemistry of C parvum oocysts to their stability in water. Capillary electrophoresis results indicated that oocysts which were washed in a phosphate buffer solution had neutrally charged surfaces. Inactivation of oocysts with formalin did not influence their electrophoretic mobility, while oocyst populations that were washed in distilled water consisted of cells with both neutral and negative surface charges. These results indicate that washing oocysts in low-ionic-strength distilled water can impart a negative charge to a fraction of the oocysts in the sample. Rapid coagulation experiments indicated that oocysts did not aggregate in a 0.5 M NaCl solution; oocyst stability in the salt solution may have been the result of Lewis acid-base forces, steric stabilization, or some other factor. The presence of sucrose and Percoll could not be readily identified on the surface of C. parvum oocysts by attenuated total reflectance-Fourier transform infrared spectroscopy, suggesting that these purification reagents may not be responsible for the stability of the uncharged oocysts. These findings imply that precipitate enmeshment may be the optimal mechanism of coagulation for removal of oocysts in water treatment systems. The results of this work may help elucidate the causes of variation in oocyst surface characteristics, may ultimately lead to improved removal efficiencies in full-scale water treatment systems, and may improve fate and transport predictions for oocysts in natural systems. C1 US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, W Point, NY 10996 USA. US Mil Acad, Dept Chem & Life Sci, W Point, NY 10996 USA. RP Butkus, MA (reprint author), US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, W Point, NY 10996 USA. NR 42 TC 28 Z9 28 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUL PY 2003 VL 69 IS 7 BP 3819 EP 3825 DI 10.1128/AEM.69.7.3819-3825.2003 PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 699XM UT WOS:000184082100017 PM 12839749 ER PT J AU Tenbrock, K Kribs, A Roth, B Speder, B AF Tenbrock, K Kribs, A Roth, B Speder, B TI Hyponatraemia as a consequence of serial liquor punctures in preterm infants with a ventricular access device after posthaemorrhagic hydrocephalus SO ARCHIVES OF DISEASE IN CHILDHOOD LA English DT Letter C1 Univ Childrens Hosp Cologne, Dept Neonatol & Pediat Intens Care, Cologne, Germany. Univ Hosp Cologne, Dept Neurosurg, Cologne, Germany. RP Tenbrock, K (reprint author), Walter Reed Army Med Ctr, MCR, Washington, DC 20307 USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU BRITISH MED JOURNAL PUBL GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0003-9888 J9 ARCH DIS CHILD JI Arch. Dis. Child. PD JUL PY 2003 VL 88 IS 4 SI SI BP 351 EP 351 PG 1 WC Pediatrics SC Pediatrics GA 696YC UT WOS:000183914300029 ER PT J AU Rotenberg, J Pearl, PL AF Rotenberg, J Pearl, PL TI Landau-Meffner syndrome SO ARCHIVES OF NEUROLOGY LA English DT Article ID CONVULSIVE DISORDER; KLEFFNER SYNDROME; ACQUIRED APHASIA; CHILDREN C1 George Washington Univ, Dept Neurol, Childrens Natl Med Ctr, Sch Med, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Dept Child & Adolescent Neurol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Pearl, PL (reprint author), George Washington Univ, Dept Neurol, Childrens Natl Med Ctr, Sch Med, 111 Michigan Ave NW, Washington, DC 20010 USA. NR 14 TC 12 Z9 12 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 USA SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD JUL PY 2003 VL 60 IS 7 BP 1019 EP 1021 DI 10.1001/archneur.60.7.1019 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA 699PH UT WOS:000184064800018 PM 12873863 ER PT J AU Pendleton, RL Pendleton, BK Howard, GL Warren, SD AF Pendleton, RL Pendleton, BK Howard, GL Warren, SD TI Growth and nutrient content of herbaceous seedlings associated with biological soil crusts SO ARID LAND RESEARCH AND MANAGEMENT LA English DT Article DE AMF; arbuscular mycorrhizal fungi; arid lands; Bromus tectorum; cryptogamic crusts; Elymus elymoides; Gaillardia pulchella; microphytic crusts; nutrient cycling; semiarid lands; Sphaeralcea munroana ID NITROGEN; PLANTS; CYANOBACTERIA; AVAILABILITY; ECOSYSTEM; FIXATION; DYNAMICS; EROSION; PRAIRIE; DESERT AB Biological soil crusts of arid and semiarid lands contribute significantly to ecosystem stability by means of soil stabilization, nitrogen fixation, and improved growth and establishment of vascular plant species. In this study, we examined growth and nutrient content of Bromus tectorum, Elymus elymoides, Gaillardia pulchella, and Sphaeralcea munroana grown in soil amended with one of three levels of biological soil crust material: (1) a low-fertility sand collected near Moab, Utah; ( 2) sand amended with a 1-cm top layer of excised soil crust; and ( 3) crushed crust material. In addition, all plants were inoculated with spores of the arbuscular mycorrhizal fungus, Glomus intraradices. Plants were harvested after 10 weeks growth, dried, weighed, and leaves were ground for nutrient analysis. Three aspects of root architecture were also quantified. Soil crust additions significantly affected nearly all variables examined. Both above- and below-ground vegetative biomass were significantly increased in the presence of crust material. Similarly, reproductive tissue of the three species that flowered was greatest in the crushed-crust medium. The effect of soil crust additions is likely due to the increased nitrogen content of the crusts. Nitrogen tissue content of all four species was greatly enhanced in crusted soils. All species showed a decline in root/shoot ratio and specific root length with crust additions, indicating a shift in plant allocation pattern in response to improved soil fertility. These data support other studies suggesting that soil crusts have a positive effect on the establishment and growth of associated vascular plant species. C1 USDA, Rocky Mt Res Stn, Forest Serv, Albuquerque, NM 87102 USA. USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL USA. RP Pendleton, RL (reprint author), USDA, Rocky Mt Res Stn, Forest Serv, 333 Broadway SE,Suite 115, Albuquerque, NM 87102 USA. EM rpendleton@fs.fed.us NR 38 TC 19 Z9 21 U1 2 U2 20 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-4982 J9 ARID LAND RES MANAG JI Arid Land Res. Manag. PD JUL PY 2003 VL 17 IS 3 BP 271 EP 281 DI 10.1080/15324980301598 PG 11 WC Environmental Sciences; Soil Science SC Environmental Sciences & Ecology; Agriculture GA 684ZD UT WOS:000183235600003 ER PT J AU Nambiar, MP Fisher, CU Warke, VG Krishnan, S Mitchell, JP Delaney, N Tsokos, GC AF Nambiar, MP Fisher, CU Warke, VG Krishnan, S Mitchell, JP Delaney, N Tsokos, GC TI Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell Receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus SO ARTHRITIS AND RHEUMATISM LA English DT Article ID DEFECTIVE PRODUCTION; IL-2 PRODUCTION; LYMPHOCYTES; EXPRESSION; TRANSDUCTION; COMPLEX AB Objective. T cells from a majority of patients with systemic lupus erythematosus (SLE) display antigen receptor-mediated signaling aberrations associated with defective T cell receptor (TCR) xi chain, a subunit of the TCR/CD3 complex. This study was undertaken to explore the possibility that forced expression of TCR chain may reverse the known signaling abnormalities and defective interleukin-2 (IL-2) production in SLE T cells. Methods. Freshly isolated SLE T cells were transfected with TCR chain construct in a eukaryotic expression vector at high efficiency, by a recently developed nucleoporation technique. Restoration of TCR/ CD3-mediated signaling was studied in the xi chain-transfected cells. Results. In SLE T cells transfected with TCR chain, surface expression of TCR chain was increased and the TCR/CD3-induced increased free intracytoplasmic calcium concentration response was normalized, as was hyperphosphorylation of cellular substrates. Simultaneously, the previously noted increased expression of the Fc receptor gamma chain was diminished in SLE T cells transfected with the chain expression vector, and the surface membrane clusters of cell signaling molecules were redistributed to a more continuous pattern. TCR chain replacement also augmented the expression of diminished TCR/CD3-mediated IL-2 production in SLE T cells, associated with increased expression of the p65 subunit of nuclear factor kappaB in the nuclear fractions of these T cells. Conclusion. These results suggest that reconstitution of deficient TCR chain can reverse the TCR/ CD3-mediated signaling abnormalities as well as the defective IL-2 production in T cells of patients with SLE. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Tsokos, GC (reprint author), Walter Reed Army Inst Res, Bldg 503,Room 1A32,Robert Grant Ave, Silver Spring, MD 20910 USA. FU NIAID NIH HHS [R01-AI-42269] NR 24 TC 68 Z9 73 U1 1 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUL PY 2003 VL 48 IS 7 BP 1948 EP 1955 DI 10.1002/art.11072 PG 8 WC Rheumatology SC Rheumatology GA 699QP UT WOS:000184067700023 PM 12847689 ER PT J AU Kraemer, WJ Armstrong, LE Watson, G AF Kraemer, WJ Armstrong, LE Watson, G TI The effects of exertional heatstroke and exercise-heat acclimation on plasma beta-endorphin concentrations SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE opioid peptides; exercise; thermal tolerance; hormones ID RESPONSES; INTENSITY; SHOCK; THERMOREGULATION; CATECHOLAMINES; HYPOTENSION; MECHANISMS; DURATION; STROKE AB Introduction: It has been suggested that a proopiomelanocortin peptide beta-endorphin may play an important role in temperature regulation and therefore have specific heat stroke response patterns. Methods: The purpose of this study was to examine the response patterns of plasma beta-endorphin at baseline, during a 7-d exercise-heat acclimation period (HA; 90 min (.) d(-1), 40degreesC), and during a 6-h exercise-heat tolerance test (HTT; 6 h, 40degreesC) performed before and after HA. Subjects were nine previously diagnosed heatstroke patients (P) and eight matched controls (C). No differences between the two groups were observed at rest, prior to HTT. Results: Plasma beta-endorphin concentration in P significantly increased above resting values at 2, 4, and 6 h of HTT and were significantly greater than C responses. During HA tests, a significantly higher beta-endorphin concentration was observed in P before exercise on day 1 and day 7, but not on clay 4. A significant increase occurred after exercise in both groups, on all days of HA; no differences were observed between the groups on clays 4 and 7. Discussion: These results demonstrate that the opioid peptide responses in individuals with recent exertional heatstroke were greater than control subjects during the initial 6-h HTT. Decreased physical training among P may have contributed to these results. However, 7 d of HA abolished these between-group differences by reducing the magnitude of beta-endorphin responses in P, indicative of an adaptation of pituitary function. C1 Univ Connecticut, Dept Kinesiol, Human Performance Lab, Storrs, CT 06269 USA. Univ Connecticut, Dept Neurobiol & Physiol, Storrs, CT 06269 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Kraemer, WJ (reprint author), Univ Connecticut, Dept Kinesiol, Human Performance Lab, Unit 1110, Storrs, CT 06269 USA. RI Watson, Greig/J-7488-2014 OI Watson, Greig/0000-0002-3438-0203 NR 21 TC 5 Z9 5 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2003 VL 74 IS 7 BP 758 EP 762 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 696RR UT WOS:000183901500010 PM 12862331 ER PT J AU Knapik, JJ Craig, SC Hauret, KG Jones, BH AF Knapik, JJ Craig, SC Hauret, KG Jones, BH TI Risk factors for injuries during military parachuting SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE parachute; weather; aircraft; training; terrain ID LANDING INJURIES; US-ARMY; NORTH-CAROLINA; FORT-BRAGG; BATTALION; ALTITUDE; WOMEN; MEN AB Introduction: Parachuting is an activity performed by a variety of occupational groups including the military, firefighters (smoke jumpers), and rescue groups. Methods: This paper systematically reviewed the literature on injury risk factors for soldiers performing static line parachuting from military aircraft. jump-related injuries were defined as those occurring from the time the soldier exited the aircraft until he or she released their parachute harness on the ground. Results and Discussion: Despite methodological differences, where two or more studies examined a particular risk factor, results were generally similar. Higher injury risk was associated with higher wind speed, night jumps, jumps from airplanes (vs. balloons and helicopters), jumps wearing additional equipment, jumps without ankle braces, uneven terrain on the drop zone, and female gender. Risk factors identified in only single studies included a greater number of soldiers exiting the aircraft, winds from the rear of the aircraft, simultaneous exits from doors on opposite sides of the aircraft, smaller parachute canopies, higher ambient air temperatures, and airborne refresher courses (vs. introductory courses). Further studies are needed which use a multivariate approach to evaluate the relative impact of the various risk factors and their interactions. Conclusions: This paper identified a number of risk factors relevant to all parachutists (e.g., wind speed, female gender) and some relevant primarily to the military and other tactical parachutists such as smoke jumpers (e.g., equipment weight). Knowledge of these risk factors can assist parachutists and those that train them in their risk analysis. Keywords: parachute, weather, aircraft, training, terrain. C1 USA, Ctr Hlth Promot & Prevent Med, MCHB, TS,EIP, Aberdeen Proving Ground, MD 21010 USA. Keller Army Community Hosp, W Point, NY USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, MCHB, TS,EIP, Aberdeen Proving Ground, MD 21010 USA. NR 33 TC 29 Z9 34 U1 2 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2003 VL 74 IS 7 BP 768 EP 774 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 696RR UT WOS:000183901500012 PM 12862333 ER PT J AU Mello, SV Mabrouki, M Cao, XH Leblanc, RM Cheng, TC DeFrank, JJ AF Mello, SV Mabrouki, M Cao, XH Leblanc, RM Cheng, TC DeFrank, JJ TI Langmuir and Langmuir-Blodgett films of organophosphorus acid anhydrolase SO BIOMACROMOLECULES LA English DT Article ID ENZYME-BASED BIOSENSOR; NERVE AGENTS; AMPEROMETRIC SENSOR; NUCLEOTIDE-SEQUENCE; BACTERIAL ENZYME; HYDROLASE; DECONTAMINATION; PURIFICATION; PESTICIDES; ANALOGS AB In this paper, we describe the preparation and characterization of Langmuir and Langmuir-Blodgett (LB) monolayers of the enzyme organophosphorus acid anhydrolase (OPAA). Langmuir films of OPAA were characterized on different subphases, such as phosphate, ammonium carbonate, and bis-tris-propane buffers. Monolayers at the air-water interface were characterized by measuring the surface pressure and surface potential-area isotherms. In situ UV-vis absorption spectra were also recorded from the Langmuir monolayers. The enzyme activity at the air-water interface was tested by the addition of diisopropylfluorophosphate (DFP) to the subphase. LB films of OPAA were transferred to mica substrates to be studied by atomic force microscopy. Finally, a one-layer LB film of OPAA labeled with a fluorescent probe, fluorescein isothiocyanate (FITC), was deposited onto a quartz slide to be tested as sensor for DFP. The clear, pronounced response and the stability of the LB film as a DFP sensor show the potential of this system as a biosensor. C1 Univ Miami, Dept Chem, Coral Gables, FL 33146 USA. USA, Edgewood Chem Biol Ctr, Biotechnol Team, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Leblanc, RM (reprint author), Univ Miami, Dept Chem, Coral Gables, FL 33146 USA. RI MABROUKI, Mustapha/B-2421-2012 OI MABROUKI, Mustapha/0000-0001-8975-9803 NR 30 TC 18 Z9 18 U1 1 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 J9 BIOMACROMOLECULES JI Biomacromolecules PD JUL-AUG PY 2003 VL 4 IS 4 BP 968 EP 973 DI 10.1021/bm025775+ PG 6 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA 704VB UT WOS:000184360400016 PM 12857080 ER PT J AU Lee, SK Stebbins, JF Weiss, CA Kirkpatrick, RJ AF Lee, SK Stebbins, JF Weiss, CA Kirkpatrick, RJ TI O-17 and Al-27 MAS and 3QMAS NMR study of synthetic and natural layer silicates SO CHEMISTRY OF MATERIALS LA English DT Article ID SOLID-STATE NMR; ANGLE-SPINNING NMR; HIGH-RESOLUTION AL-27; OXYGEN SITE EXCHANGE; AL-O-AL; MAGIC-ANGLE; ALUMINOSILICATE GLASSES; CLAY-MINERALS; HIGH-FIELD; QUADRUPOLAR NUCLEI AB We report O-17 and Al-27 NMR results for O-17-enriched synthetic and natural layer silicates with significantly improved resolution of oxygen sites including basal and apical oxygens using O-17 3QMAS NMR spectroscopy. These oxygen sites have well-defined ranges of O-17 isotropic chemical shifts (delta(iso)) and quadrupolar coupling constants (C-q). The C-q of basal oxygen (Si-[4]-O-Si-[4]) range from 4.1 to 5.2 MHz for these phases, and delta(iso) varies from 39 to 55 ppm. The delta(iso) value of the basal oxygen sites increases with increasing C-q. The C-q and delta(iso) values of apical oxygens (Si-[4]-O-2([6])Al) are about 3.4 MHz and about 64 ppm, respectively, and are similar among the phases examined. The hydroxyl group (2([6])Al-OH) has the largest Cq (about 7 MHz) among the oxygen sites, as well as the most shielded chemical shift of about 37-44 ppm. Analysis of the Al-27 MAS NMR spinning sideband manifolds yields precise NMR parameters for the Al-[6] sites. Al-27 MAS and 3QMAS NMR spectroscopies at 14.1 T yield excellent quantification of the Al-[6]/Al-[4] ratio of 2 for natural muscovite. The methods described here, in particular O-17 3QMAS at high H-0 field (14.1 T), are effective probes of crystallographically distinct sites with similar C-q and delta(iso) value in layer silicates and are thus potentially useful for characterizing the complex and heterogeneous natural layer silicates and other nanoscale earth materials, such as crystalline and amorphous oxyhydoxides and oxides. C1 Carnegie Inst Washington, Geophys Lab, Washington, DC 20015 USA. Stanford Univ, Dept Geol & Environm Sci, Stanford, CA 94305 USA. USA, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA. Univ Illinois, Dept Geol, Urbana, IL 61801 USA. RP Lee, SK (reprint author), Carnegie Inst Washington, Geophys Lab, 5251 Broad Branch Rd NW, Washington, DC 20015 USA. NR 51 TC 18 Z9 18 U1 4 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD JUL 1 PY 2003 VL 15 IS 13 BP 2605 EP 2613 DI 10.1021/cm030165h PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 695BE UT WOS:000183810600017 ER PT J AU Shorr, AF Humphreys, CW Helman, DL AF Shorr, AF Humphreys, CW Helman, DL TI New choices for central venous catheters - Potential financial implications SO CHEST LA English DT Article DE bacteremia; catheter-related bloodstream infection; central venous catheter; cost; cost-effectiveness; infection; nosocomial; prevention ID BLOOD-STREAM INFECTION; CRITICALLY ILL PATIENTS; COST-EFFECTIVENESS; CONTROLLED TRIAL; INTENSIVE-CARE; DOUBLE-BLIND; PREVENTION; RISK; MORTALITY; PATIENT AB Objective: To determine the cost-effectiveness of the newer antiseptic and antibiotic-impregnated central, venous catheters (CVCs) relative to uncoated CVCs and to each other. Design: Decision model analysis of the cost and efficacy of CVCs coated with either chlorhexidine silver sulfadiazine (CSS) or rifampin-minocycline (RM) at preventing catheter-related bloodstream infections (CRBSIs). The primary outcome is the incremental cost (or savings) to prevent one additional CRBSI. Model estimates are derived from prospective trials of the CSS and RM CVCs and from other studies describing the costs of CRBSIs. Setting and patients: Hypothetical cohort of 1,000 patients requiring placement of a CVC. Interventions: In the model, patients were managed with either an uncoated CVC, CSS CVC, or RM CVC. Measurements and main results: The incremental cost-effectiveness of the treated CVCs was calculated as the savings resulting. from CRBSIs averted less the additional costs of the newer devices. Sensitivity analysis of the effect of the major clinical inputs was performed. For the base case analysis, we assumed the incidence of CRBSIs was 3.3% with traditional catheters and that the CSS and RM CVC conferred a relative risk reduction for the development of CRBSIs of 60% and 85%, respectively. Despite their significantly higher cost than older catheters, both novel CVCs yield significant savings. Employing either of the treated CVCs saves approximately $10,000 per CRBSI prevented (relative to standard catheters). Comparing the RM CVC to the CSS CVC revealed the RM product to be economically superior, saving nearly $9,600 per CRBSI averted and $81 per patient in the cohort. For sensitivity analysis, we adjusted all model variables by 50% individually and then simultaneously. This demonstrated the model to be most sensitive to the cost of a CRBSI; however, with all inputs skewed by 50% against both the CSS CVC and the RM CVC, these devices remained economically attractive. Under this scenario, use of either treated device was less costly. Conclusions: Utilization of antiseptic and antibiotic-impregnated CVCs represent an attractive alternative for the prevention of CRBSIs and may lead to significant savings. Of the two newer, coated devices, the RM CVC performs better financially. These observations hold over a range of estimates for our model inputs. C1 Walter Reed Army Med Ctr, Dept Med, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. RP Shorr, AF (reprint author), 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 38 TC 49 Z9 51 U1 1 U2 3 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD JUL PY 2003 VL 124 IS 1 BP 275 EP 284 DI 10.1378/chest.124.1.275 PG 10 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 701KP UT WOS:000184167000044 PM 12853534 ER PT J AU Butler, RJ Crowell, HP Davis, IM AF Butler, RJ Crowell, HP Davis, IM TI Lower extremity stiffness: implications for performance and injury SO CLINICAL BIOMECHANICS LA English DT Article ID LEG STIFFNESS; STRIDE FREQUENCY; JOINT STIFFNESS; IMPACT FORCES; ANKLE JOINT; LANDINGS; SURFACES; ENERGETICS; MECHANICS; KINETICS AB Background. Lower extremity stiffness is thought to be an important factor in musculoskeletal performance. However, too little or too much stiffness is believed to increase the risk of musculoskeletal injury. Purpose. To provide a current update of the lower extremity stiffness literature as it pertains to both performance and injury. Summary. It appears that increased stiffness is beneficial to performance. As well it appears that there may be an optimal amount of stiffness that allows for injury-free performance. There is some evidence that increased stiffness may be related to bony injuries and decreased stiffness may be associated with soft tissue injuries. Further investigations should evaluate the relationship between stiffness and injury prospectively. Initial reports suggest that stiffness can be modified in response to the external environment or verbal cues. C1 Univ Delaware, Biomech & Movement Sci Program, Newark, DE 19716 USA. USA, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Joyner Sportsmed Inst, Mechanicsburg, PA 17111 USA. RP Butler, RJ (reprint author), Univ Delaware, Biomech & Movement Sci Program, Newark, DE 19716 USA. NR 36 TC 168 Z9 173 U1 1 U2 42 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0268-0033 J9 CLIN BIOMECH JI Clin. Biomech. PD JUL PY 2003 VL 18 IS 6 BP 511 EP 517 DI 10.1016/S0268-0033(03)00071-8 PG 7 WC Engineering, Biomedical; Orthopedics; Sport Sciences SC Engineering; Orthopedics; Sport Sciences GA 699NN UT WOS:000184063000008 PM 12828900 ER PT J AU Hao, D Hammond, LA Eckhardt, SG Patnaik, A Takimoto, CH Schwartz, GH Goetz, AD Tolcher, AW McCreery, HA Mamun, K Williams, JI Holroyd, KJ Rowinsky, EK AF Hao, D Hammond, LA Eckhardt, SG Patnaik, A Takimoto, CH Schwartz, GH Goetz, AD Tolcher, AW McCreery, HA Mamun, K Williams, JI Holroyd, KJ Rowinsky, EK TI A phase I and pharmacokinetic study of squalamine, an aminosterol angiogenesis inhibitor SO CLINICAL CANCER RESEARCH LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the American-Society-of-Clinical-Oncology CY MAY 19-23, 2000 CL NEW ORLEANS, LA SP Amer Soc Clin Oncol ID CANCER; THERAPY; TUMORS AB Purpose: The purpose of this study was to assess the feasibility and characterize the pharmacokinetics of squalamine administered as a continuous i.v. infusion daily for 5 days every 3 weeks. Experimental Design: Patients with advanced solid malignancies were treated with escalating doses of squalamine as a 5-day continuous i.v. infusion every 3 weeks. Doses were initially escalated in 100% increments from a starting dose of 6 mg/m(2)/day, with a single patient treated at each dose level until moderate toxicity was observed, at which time additional patients were treated. Results: Thirty-three patients were treated with 73 courses of squalamine at 13 dose levels ranging from 6 to 700 mg/m(2)/day. Hepatotoxicity, characterized by brief, asymptomatic elevations in transaminases and hyperbilirubinemia, was the principal dose-limiting toxicity of squalamine. At 700 mg/m(2)/day, two of three patients developed grade 4 hyperbilirubinemia, which precluded further dose escalation. At 500 mg/m(2)/day, one of seven patients experienced dose-limiting grade 4 hyperbilirubinemia and grade 3 neurosensory changes, which resolved soon after treatment. Squalamine pharmacokinetics were dose-proportional. At 500 mg/m(2)/day, the mean (percentage coefficient of variation) clearance, half-life, and volume of distribution of squalamine were 2.67 liters/h/m(2) (85%), 9.46 h (81%), and 36.84 liters/m(2) (124%), respectively, and steady-state concentrations [20.08 mug/ml (13%)] were well above those that inhibit angiogenesis in preclinical models. Conclusions: At the recommended Phase II dose of 500 mg/m(2)/day, squalamine is well tolerated and results in plasma concentrations at least an order of magnitude higher than those required for prominent antiangiogenic effects in preclinical studies. C1 Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA. Univ Texas Hlth Ctr, San Antonio, TX USA. USA, Brooke Army Med Ctr, San Antonio, TX USA. Genaera Corp, Plymouth Meeting, PA USA. RP Rowinsky, EK (reprint author), Canc Therapy & Res Ctr S Texas, Inst Drug Dev, 7979 Wurzbach Rd,Suite 414, San Antonio, TX 78229 USA. EM erowinsk@saci.org FU NCRR NIH HHS [M01RR01346] NR 19 TC 30 Z9 35 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD JUL PY 2003 VL 9 IS 7 BP 2465 EP 2471 PG 7 WC Oncology SC Oncology GA 700JK UT WOS:000184108700012 PM 12855619 ER PT J AU Garrison, MA Hammond, LA Geyer, CE Schwartz, G Tolcher, AW Smetzer, L Figueroa, JA Ducharme, M Coyle, J Takimoto, CH De Jager, RL Rowinsky, EK AF Garrison, MA Hammond, LA Geyer, CE Schwartz, G Tolcher, AW Smetzer, L Figueroa, JA Ducharme, M Coyle, J Takimoto, CH De Jager, RL Rowinsky, EK TI A phase I and pharmocokinetic study of exatecan mesylate administered as a protracted 21-day infusion in patients with advanced solid malignancies SO CLINICAL CANCER RESEARCH LA English DT Article ID CANCER CELL-LINE; POTENT ANTITUMOR-ACTIVITY; CAMPTOTHECIN ANALOG; TOPOISOMERASE-I; TOPOTECAN INFUSION; ACTIVE METABOLITE; CARCINOMA-CELLS; NUDE-MICE; DX-8951F; RESISTANT AB Purpose: The purpose of this study was to assess the feasibility of administering exatecan, a water-soluble, potent camptothecin analogue, as a protracted 21-day continuous i.v. infusion (CIVI). The study also sought to determine the maximum tolerated dose (MTD) of exatecan on a 21-day CIVI schedule, characterize its pharmacokinetic behavior, and seek preliminary evidence of anticancer activity. Experimental Design: Exatecan dose-schedule development was performed in two stages using the modified Continual Reassessment Method and single patient cohorts. First, patients with advanced solid malignancies were treated with exatecan (0.15 mg/m(2)/day) as a CIVI for 5 days, and the duration of the CIVI was incrementally increased from 5 to 21 days. In the second stage of the study, the dose was incrementally increased to derive a tolerable dose of exatecan administered as 21-day CIVI. The MTD was defined for both minimally pretreated (MP) and heavily pretreated (HP) patients as the highest dose level at which the incidence of dose-limiting toxicity does not exceed 20%. Results: Thirty-one patients were treated with 100 courses of exatecan at 6 dose-schedule levels. The incidence of the principal dose-limiting toxicities, neutropenia and thrombocytopenia, was unacceptably high at exatecan doses exceeding 0.15 mg/m(2)/day as a 21-day CIVI, which was determined to be the MTD for both MP and HP patients. The pharmacokinetics of exatecan were dose-proportional, and mean [coefficient of variation (percentage) steady-state concentration (plasma concentration at steady-state)] values ranged from 6.88 (80.6) to 19.41 (74.2) ng/ml at exatecan dose levels ranging from 0.15 to 0.30 mg/m(2)/day, which are similar to IC50 values against human tumor cell lines treated for shorter periods. Mean pharmacokinetic parameters for total exatecan derived from a compartmental model included clearance and volume of distribution values of 1.39 (86.9) liters/h/m(2) and 39.66 (197.4) liters, respectively. Two HP patients with non-small cell lung and unknown primary carcinomas had partial responses, and objective evidence of anticancer activity and clinical benefit were noted in several other individuals. Conclusions: The administration of exatecan as a 21-day CIVI at doses as high as 0.15 mg/m2/day is safe and feasible for both MP and HP patients. The characteristics of the myelosuppressive effects of exatecan on this schedule, the paucity of severe nonhematological toxicities, and documented anticancer activity in several drug-refractory malignancies warrant further evaluation of the merits of administering exatecan by either a CIVI or alternate drug delivery systems to achieve protracted systemic exposure. C1 Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA. Brooke Army Med Ctr, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Joe Arrington Canc Ctr, Lubbock, TX USA. MDS Pharma Serv, Montreal, PQ, Canada. Daiichi Pharmaceut Corp, Montvale, NJ USA. RP Rowinsky, EK (reprint author), Canc Therapy & Res Ctr S Texas, Inst Drug Dev, 7979 Wurzbach Rd,4th Floor,Zeller Bldg, San Antonio, TX 78229 USA. FU NCRR NIH HHS [M01RR01346] NR 40 TC 12 Z9 12 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI BIRMINGHAM PA PO BOX 11806, BIRMINGHAM, AL 35202 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD JUL PY 2003 VL 9 IS 7 BP 2527 EP 2537 PG 11 WC Oncology SC Oncology GA 700JK UT WOS:000184108700020 PM 12855627 ER PT J AU Gao, CL Rawal, SK Sun, L Ali, A Connelly, RR Banez, LL Sesterhenn, IA Mcleod, DG Moul, JW Srivastava, S AF Gao, CL Rawal, SK Sun, L Ali, A Connelly, RR Banez, LL Sesterhenn, IA Mcleod, DG Moul, JW Srivastava, S TI Diagnostic potential of prostate-specific antigen expressing epithelial cells in blood of prostate cancer patients SO CLINICAL CANCER RESEARCH LA English DT Article ID POLYMERASE-CHAIN-REACTION; PELVIC LYMPH-NODES; RADICAL PROSTATECTOMY; CARCINOMA-CELLS; BONE-MARROW; RT-PCR; CIRCULATING CELLS; MOLECULAR MARKERS; PERIPHERAL-BLOOD; TUMOR-CELLS AB Purpose: Prostate-specific antigen (PSA) test has become a widely used screening test in prostate cancer (CaP). However, low specificity of serum PSA leads to many false-positive and false-negative results and clinical uncertainty. Development of CaP-specific diagnostic and prognostic markers is needed. Detection of circulating PSA-expressing cells (CPECs) in blood and bone marrow of CaP patients has potential in molecular diagnosis and prognosis. Our novel observations of the frequent presence of CPECs in CaP patients with organ-confined disease by reverse transcription (RT)-PCR-PSA assay in epithelial cells enriched from peripheral blood (ERT-PCR/PSA) have led us to test the hypothesis that CPECs have diagnostic potential for CaP. Experimental Design: Epithelial cells from peripheral blood of radical prostatectomy patients or prostate biopsy patients were isolated using antiepithelial cell antibody, Ber-EP4-coated magnetic beads, and total RNA specimens from these cells were analyzed for PSA expression by RT-PCR. Results: Peripheral blood specimens of 108 of 135 (80.0%) CaP patients were positive in ERT-PCR/PSA assay. Peripheral blood specimens from 45 control men were virtually negative (97.8%). In the blinded investigation, 84 patients who had biopsy for suspicion of CaP were evaluated by ERT-PCR/PSA assay. Eighteen of 22 (81.8%) patients with biopsy-proven CaP were positive, and 54 of 62 (87.1%) patients with biopsy negative for CaP were negative in this assay (P < 0.001). Conclusions: Our study provides intriguing novel results showing that the majority of patients with clinically organ-confined CaP contain CPECs. Strong concordance between the biopsy results and ERT-PCR/PSA assay (sensitivity 81.8%; specificity 87.1%) suggests a potentially new diagnostic application of this type of assay in CaP diagnosis. C1 Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Bethesda, MD 20814 USA. Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. NR 43 TC 25 Z9 27 U1 0 U2 3 PU AMER ASSOC CANCER RESEARCH PI BIRMINGHAM PA PO BOX 11806, BIRMINGHAM, AL 35202 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD JUL PY 2003 VL 9 IS 7 BP 2545 EP 2550 PG 6 WC Oncology SC Oncology GA 700JK UT WOS:000184108700022 PM 12855629 ER PT J AU Lin, BC Vahey, MT Thach, D Stenger, DA Pancrazio, JJ AF Lin, BC Vahey, MT Thach, D Stenger, DA Pancrazio, JJ TI Biological threat detection via host gene expression profiling SO CLINICAL CHEMISTRY LA English DT Review ID VIRUS-INDUCED DISEASE; OLIGONUCLEOTIDE ARRAYS; INDUCED MODULATION; FACE RECOGNITION; HIV-1 INFECTION; CELLS; MICROARRAY; PROGRAMS; REVEALS; MOUSE AB With the increased threat posed by biological weapons, detection techniques for biothreat pathogens are critically needed to monitor and assess the severity of the illness once exposure has occurred. Current approaches for detecting biological threats are either time-consuming or highly specific but provide little information regarding pathogenicity. Genotyping of pathogens by PCR provides a fast and definitive means for identifying pathogens, but reliance on Pathogen genotypic endpoints has several limitations. Current progress in DNA microarrays technology provides an alternative way to address the issues faced by traditional detection systems through host gene expression of peripheral blood cells. We discuss the advantages and critical issues facing the use of host gene expression profiling for biological threat detection. (C) 2003 American Association-for Clinical Chemistry. C1 USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. RP Lin, BC (reprint author), USN, Res Lab, Ctr Biomol Sci & Engn, Code 6900, Washington, DC 20375 USA. RI Lin, Baochuan/A-8390-2009; Pancrazio, Joseph/M-3206-2015 OI Lin, Baochuan/0000-0002-9484-0785; Pancrazio, Joseph/0000-0001-8276-3690 NR 38 TC 6 Z9 7 U1 0 U2 1 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD JUL PY 2003 VL 49 IS 7 BP 1045 EP 1049 DI 10.1373/49.7.1045 PG 5 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 694TD UT WOS:000183789600004 PM 12816899 ER PT J AU Schoenfeld, PS Fincher, RK AF Schoenfeld, Philip S. Fincher, Roger Keith CA Military Colorectal Canc Screening TI Colonoscopic Surveillance of Patients With a Family History of Colon Cancer and a History of Normal Colonoscopy: Is a Five-Year Interval Between Colonoscopies Appropriate? SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article AB Background & Aims: Patients with a family history of colon cancer are advised to undergo surveillance colonoscopy 5 years after a normal screening colonoscopy. No prospective study has evaluated the prevalence of adenomas found at surveillance colonoscopy in these patients. The aims of this trial were (1) to determine the percentage of these patients with adenomas; (2) to determine the percentage of these patients with advanced adenomas (i.e., villous adenomas, adenomas >= 10 mm, adenomas with high grade dysplasia); and (3) to assess risk factors for adenomas in these patients. Methods: Consecutive patients with a family history of colorectal cancer and a normal screening colonoscopy 5 years earlier were offered a surveillance colonoscopy. Patients also completed a questionnaire about potential risk factors for adenomas. Multiple logistic regression analysis assessed associations between risk factors and adenomas. Results: One hundred patients completed the trial. The male/female ratio was 54/46, the mean age was 56.2 +/- 8.8 years, and 91% were white. Eight percent (8 of 100) of patients had advanced adenomas at surveillance colonoscopy, and 33% (33 of 100) had adenomas. Among patients with adenomas, 39% (13 of 33) had no adenomas in the left side of the colon (i.e., distal to the splenic flexure). Among patients with advanced adenomas, 25% (2 of 8) had no adenomas in the left side of the colon. Multiple logistic regression analysis showed a significant negative association between adenomas and NSAID use (odds ratio, 0.26 [95% confidence interval, 0.09-0.79]), and male gender had a positive association with adenomas (odds ratio, 2.79 [95% confidence interval, 1.01-7.74]). Conclusions: These data support a 5-year interval between screening and surveillance colonoscopy for patients with a family history of colorectal cancer and a normal screening colonoscopy. C1 [Schoenfeld, Philip S.] Univ Michigan, Sch Med, Div Gastroenterol, Ann Arbor, MI USA. [Schoenfeld, Philip S.] Ann Arbor VA Ctr Hlth Serv Res, Ann Arbor, MI USA. [Fincher, Roger Keith] Walter Reed Army Med Ctr, Div Gastroenterol, Washington, DC 20307 USA. RP Schoenfeld, PS (reprint author), VAMC 111-D,2215 Fuller Rd, Ann Arbor, MI 48195 USA. EM pssmd@aol.com NR 22 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD JUL PY 2003 VL 1 IS 4 BP 310 EP 314 DI 10.1016/S1542-3565(03)00136-8 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA V19KJ UT WOS:000208071000012 PM 15017673 ER PT J AU Boles, JW Pitt, MLM LeClaire, RD Gibbs, PH Torres, E Dyas, B Ulrich, RG Bavari, S AF Boles, JW Pitt, MLM LeClaire, RD Gibbs, PH Torres, E Dyas, B Ulrich, RG Bavari, S TI Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity SO CLINICAL IMMUNOLOGY LA English DT Article DE bacterial superantigens; vaccine; SEB; biomarkers; aerosol ID BIOLOGICAL WARFARE AGENTS; BACTERIAL SUPERANTIGENS; CLINICAL RECOGNITION; INTERLEUKIN-8 IL-8; CRYSTAL-STRUCTURE; A SEA; RESPONSES; AUREUS; MANAGEMENT; ANTIBODIES AB At this time there are no vaccines or therapeutics to protect against staphylococcal enterotoxin B (SEB) exposure. Here, we report vaccine efficacy of an attenuated SEB in a nonhuman primate model following lethal aerosol challenge and identify several biomarkers of protective immunity. Initial in vitro results indicated that the mutation of key amino acid residues in the major histocompatibility complex (MHC) class II binding sites of SEB produced a nontoxic form of SEB, which had little to no detectable binding to MHC class II molecules, and lacked T-cell stimulatory activities. When examined in a mouse model, we found that the attenuated SEB retained antigenic structures and elicited protective immune responses against wild-type SEB challenge. Subsequently, a vaccine regimen against SEB in a nonhuman primate model was partially optimized, and investigations of immune biomarkers as indicators of protection were per-formed. SEB-naive rhesus monkeys were vaccinated two or three times with 5 or 20 mug of the attenuated SEB and challenged by aerosol with wild-type SEB toxin. Unlike exposure to the native toxin, the vaccine did not trigger the release of inflammatory cytokines (TNFalpha, IL6, or IFNgamma). All rhesus monkeys that developed anti-SEB serum titers greater than or equal to 10(4) and elicited high levels of neutralizing antibody survived the aerosol challenge. These findings suggest that the attenuated SEB is fully protective against aerosolized toxin when administered to unprimed subjects. Moreover, experiments presented in this study identified various biomarkers that showed substantial promise as correlates of immunity and surrogate endpoints for assessing in vivo biological responses in primates, and possibly in humans, to vaccines against SEs. (C) 2003 Elsevier Science (USA). All rights reserved. C1 USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. NR 27 TC 41 Z9 49 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD JUL PY 2003 VL 108 IS 1 BP 51 EP 59 DI 10.1016/S1521-6616(03)00066-4 PG 9 WC Immunology SC Immunology GA 702XF UT WOS:000184249500007 PM 12865071 ER PT J AU Carra, JH Welcher, BC Schokman, RD David, CS Bavari, S AF Carra, JH Welcher, BC Schokman, RD David, CS Bavari, S TI Mutational effects on protein folding stability and antigenicity: the case of streptococcal pyrogenic exotoxin A SO CLINICAL IMMUNOLOGY LA English DT Article DE SPEA; superantigen; exotoxin; vaccine; DSC; circular dichroism; protein folding ID STAPHYLOCOCCAL ENTEROTOXIN-A; HUMAN-ANTIBODIES; CELL EPITOPES; MHC CLASS; BINDING; IMMUNOGENICITY; NEUTRALIZATION; SUPERANTIGENS; RECOGNITION; PYOGENES AB The influence of mutationally induced changes in protein folding on development of effective neutralizing antibodies during vaccination remains largely unexplored. In this study, we probed how mutational substitutions of streptococcal pyrogenic exotoxin A (SPEA), a model bacterial superantigen, affect native conformational stability and antigenicity. Stability changes for the toxin variants were determined using circular dichroism and fluorescence measurements, and scanning calorimetry. Self-association was assayed by dynamic light scattering. Inactivated SPEA proteins containing particular combinations of mutations elicited antibodies in HLA-DQ8 transgenic mice that neutralized SPEA superantigenicity in vitro, and protected animals from lethal toxin challenge. However, a highly destabilized cysteine-free mutant of SPEA did not provide effective immunity, nor did an irreversibly denatured version of an otherwise effective mutant protein. These results suggest that protein conformation plays a significant role in generating effective neutralizing antibodies to this toxin, and may be an important factor to consider in vaccine design. (C) 2003 Elsevier Science (USA). All rights reserved. C1 USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA. RP Carra, JH (reprint author), USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, 1425 Porter St, Frederick, MD 21702 USA. NR 37 TC 6 Z9 6 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD JUL PY 2003 VL 108 IS 1 BP 60 EP 68 DI 10.1016/S1521-6616(03)00058-5 PG 9 WC Immunology SC Immunology GA 702XF UT WOS:000184249500008 PM 12865072 ER PT J AU Marini, AM Choi, TY Labutta, RJ AF Marini, AM Choi, TY Labutta, RJ TI Transient neurologic deficits associated with carbamazepine-induced hypertension SO CLINICAL NEUROPHARMACOLOGY LA English DT Review AB Carbamazepine is a well-established, effective treatment of complex partial seizures and is well tolerated in most patients. The adverse effects of carbamazepine include aplastic anemia, agranulocytosis, pancytopenia, bone marrow depression, thrombocytopenia, cardiac conduction abnormalities, congestive heart failure, and peripheral edema. Hypertension or hypotension has also rarely been documented in patients with either therapeutic or toxic blood levels of carbamazepine. It is possible that carbamazepine-induced hypertension in those with therapeutic blood levels is rarely seen because most of the patients who begin treatment are young and do not have baseline hypertension. The authors describe a patient of African-American descent with a history of controlled essential hypertension who developed severe uncontrolled hypertension when started on carbamazepine. Treatment with additional antihypertensive medications did not reduce his blood pressure. In addition, he developed two episodes of transient neurologic deficits, the symptoms of which consisted of dysarthria, vertigo, and unstable gait. A substantial reduction of his carbamazepine dose resulted in the control of his blood pressure and no recurrence of his symptoms. C1 Uniformed Serv Univ Hlth Sci, Dept Neurol & Neurosci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Neurol, Washington, DC USA. RP Marini, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol & Neurosci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM amarini@usuhs.mil NR 7 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-5664 J9 CLIN NEUROPHARMACOL JI Clin. Neuropharmacol. PD JUL-AUG PY 2003 VL 26 IS 4 BP 174 EP 176 DI 10.1097/00002826-200307000-00003 PG 3 WC Clinical Neurology; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA 806DJ UT WOS:000220414300003 PM 12897634 ER PT J AU Abrate, S Dooley, R Kaste, R Thibault, G Millette, W AF Abrate, S Dooley, R Kaste, R Thibault, G Millette, W TI Nonlinear dynamic behavior of parachute static lines SO COMPOSITE STRUCTURES LA English DT Article; Proceedings Paper CT 14th US National Congress of Theoretical and Applied Mechanics CY JUN 23-28, 2002 CL BLACKSBURG, VIRGINIA AB Static line deployed parachute jumping is the most efficient technique used by the United States Army Airborne Corp to deliver paratroopers to target drop-zones. The static line connects the parachute pack worn by the jumper to the anchor line of the jump aircraft. When the jumper exits the aircraft, slack in the static line is drawn tight as the jumper falls below and to the rear of the aircraft. The resulting tensile force generated in the static line achieves a magnitude of approximately 400 pounds before the parachute pack-closing loop is torn open thereby initiating canopy deployment. In some instances, the jumper becomes entangled in the line and prevents the appropriate tensile force from reaching the pack-closing loop. In most of these cases, the jumper remains entangled and is towed back into the aircraft by a high-speed winch connected to the onboard terminal of the anchor line. On rare occasions, the static line fails and the jumper is required to manually activate the reserve parachute to avoid fatal impact with the ground. Static lines are complex fabric structures that exhibit highly nonlinear behavior while experiencing large deformations. Quasistatic tests were conducted to characterize the behavior of these materials. Drop weight tests simulating actual parachute jumps were also conducted. The forces applied to the test lines were recorded as functions of time. This data is used to determine the force-elongation behavior of the line during the dynamic tests. Results indicate that a significant amount of energy is dissipated during the loading-unloading process. The behavior during the loading phase is similar to that observed during static tests. The unloading phase is significantly different. A mathematical model for the predicting the dynamic response is presented. (C) 2003 Elsevier Science Ltd. All rights reserved. C1 So Illinois Univ, Coll Engn, Dept Technol, Carbondale, IL 62901 USA. USA, Res Lab, AMSRL, WM MB, Aberdeen Proving Ground, MD 21005 USA. USA, AMSSB, RAD DN, Soldier & Biol Command, Natick, MA 01760 USA. RP Abrate, S (reprint author), So Illinois Univ, Coll Engn, Dept Technol, Carbondale, IL 62901 USA. NR 3 TC 9 Z9 9 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD JUL-AUG PY 2003 VL 61 IS 1-2 BP 3 EP 12 DI 10.1016/S0263-8223(03)00025-4 PG 10 WC Materials Science, Composites SC Materials Science GA 683KT UT WOS:000183147900002 ER PT J AU Dandekar, DP Hall, CA Chhabildas, LC Reinhart, WD AF Dandekar, DP Hall, CA Chhabildas, LC Reinhart, WD TI Shock response of a glass-fiber-reinforced polymer composite SO COMPOSITE STRUCTURES LA English DT Article; Proceedings Paper CT 14th US National Congress of Theoretical and Applied Mechanics CY JUN 23-28, 2002 CL BLACKSBURG, VIRGINIA DE composite; shock wave; compression; release; Hugoniot elastic limit AB The present work describes the compression and release response of a glass-fiber-reinforced polyester composite (GRP) under shock loading to 20 GPa. Shock experiments in GRP were performed at Sandia National Laboratories and the US Army Research Laboratory. GRP is a heterogeneous material. The diagnostic measurements fluctuate beyond the precision of the experimental measurements but they do permit determination of an average response of the material at the end state. These experiments show that: (i) GRP deforms elastically in compression to at least 1.3 GPa; (ii) the deformation coordinates of shocked and re-shocked GRP lie on the deformation locus of initially shocked GRP to 4.3 GPa; (iii) and the release path of GRP shocked to varying magnitudes of stresses indicate that the GRP expands such that its density when stresses are released in the range of 3-5 GPa from a peak compressive stress of 9 GPa and above is lower than the initial density of GRP. Possible reasons for the observed lower density remain to be investigated. Published by Elsevier Science Ltd. C1 USA, Res Lab, Terminal Effects Div, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. Sandia Natl Labs, Dept 1610, Albuquerque, NM 87185 USA. RP Dandekar, DP (reprint author), USA, Res Lab, Terminal Effects Div, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. NR 16 TC 35 Z9 38 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD JUL-AUG PY 2003 VL 61 IS 1-2 BP 51 EP 59 DI 10.1016/S0263-8223(03)00031-X PG 9 WC Materials Science, Composites SC Materials Science GA 683KT UT WOS:000183147900006 ER PT J AU Cheeseman, BA Bogetti, TA AF Cheeseman, BA Bogetti, TA TI Ballistic impact into fabric and compliant composite laminates SO COMPOSITE STRUCTURES LA English DT Article; Proceedings Paper CT 14th US National Congress of Theoretical and Applied Mechanics CY JUN 23-28, 2002 CL BLACKSBURG, VIRGINIA DE ballistic impact; fabric; armor-grade composite ID MECHANICAL-BEHAVIOR; FAILURE MECHANISMS; FIBER COMPOSITES; ARAMID FABRICS; KEVLAR FIBER; STRAIN-RATE; POLYETHYLENE; PROJECTILES; FRICTION; ARMOR AB The development of tough, high-strength, high-modulus fibers has led to the use of fabrics and compliant composite laminates for a number of impact-related applications, such as turbine blade containment, fuselage protection and body armor. Numerous studies have been conducted to identify material properties and system mechanisms that are important to the performance of these ballistic textiles. The current paper presents a review of the factors that influence ballistic performance; specifically, the material properties of the yarn, fabric structure, projectile geometry and velocity, far field boundary conditions, multiple plies and friction. Each physical mechanism is described in detail, and original references are cited to allow further investigation. Published by Elsevier Science Ltd. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Cheeseman, BA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 58 TC 231 Z9 240 U1 7 U2 95 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD JUL-AUG PY 2003 VL 61 IS 1-2 BP 161 EP 173 DI 10.1016/S0263-8223(03)00029-1 PG 13 WC Materials Science, Composites SC Materials Science GA 683KT UT WOS:000183147900015 ER PT J AU Harris-Stith, R Erickson, QL Elston, DM David-Bajar, K AF Harris-Stith, R Erickson, QL Elston, DM David-Bajar, K TI Bullous eruption: A manifestation of lupus erythematosus SO CUTIS LA English DT Article ID VII COLLAGEN; BLISTERING DISEASES; ACQUISITA AB Bullous lupus erythematosus (BSLE) is a rare subset of systemic lupus erythematosus (SLE), often associated with autoimmunity to type VII collagen. Generally, patients with BSLE meet the criteria for SLE as defined by the American College of Rheumatology We present a case of a 17-year-old adolescent girl who presented with a vesiculobullous eruption without detectable type VII collagen antibodies and without full criteria for SLE. Differential staining was characteristic for lupus erythematosus (LE), suggesting her eruption is related to LE. We review the spectrum of bullous disease in patients with LE and discuss the pathogenesis and histology of these eruptions, as well as current therapeutic options. C1 Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. Wilford Hall USAF Med Ctr, Lackland AFB, San Antonio, TX 78236 USA. Brooke Army Med Ctr, San Antonio, TX USA. Goodfellow AFB, Goodfellow AFB, TX USA. RP Elston, DM (reprint author), Geisinger Med Ctr, Dept Dermatol, 100 N Acad Ave, Danville, PA 17822 USA. NR 16 TC 14 Z9 15 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD JUL PY 2003 VL 72 IS 1 BP 31 EP 37 PG 7 WC Dermatology SC Dermatology GA 701XX UT WOS:000184195200004 PM 12889712 ER PT J AU Pashley, DH Agee, KA Carvalho, RM Lee, KW Tay, FR Callison, TE AF Pashley, DH Agee, KA Carvalho, RM Lee, KW Tay, FR Callison, TE TI Effects of water and water-free polar solvents on the tensile properties of demineralized dentin SO DENTAL MATERIALS LA English DT Article DE collagen; tensile properties; modulus of elasticity; ultimate tensile stress; hydrogen bonding; solubility parameters ID SOLUBILITY PARAMETER; DIMENSIONAL CHANGES; COLLAGEN-FIBERS; MATRIX; STRENGTH; RESIN; HEMA AB Objectives. The aim of this study was to test the null hypothesis that the tensile properties of demineralized dentin are not influenced by the hydrogen bonding ability of anhydrous polar solvents. Methods. Dentin disks 0.5 mm thick were prepared from mid-coronal dentin of extracted, unerupted, human third molars. `I' beam and hour-glass shaped specimens were prepared from the disks, the ends protected with nail varnish and the central regions completely demineralized in 0.5 M EDTA for 5 days. Ultimate tensile stress (UTS) and low-strain apparent modulus of elasticity (E) were determined with the specimens immersed for 60 min in water, methanol, HEMA, acetone or air prior to testing in those same media. Apparent moduli of elasticity were measured on the same specimens in a repeated measures experimental design. The results were analyzed with a one-way ANOVA on ranks, followed by Dunn's test at alpha = 0.05. Regression analysis examined the relationship between UTS or E and Hansen's solubility parameter for hydrogen bonding (delta(h)) of each solvent. Results. The UTS of demineralized dentin in water, methanol, HEMA, acetone and air was 18(7), 29(7), 31(6), 41(13) and 146(27) MPa, (x) over bar (SD), n = 10. Low-strain E for the same media were 11(7), 43(12), 79(21), 132(31) and 253(115) MPa. Regression analysis of UTS vs delta(h) revealed a significant (p < 0.0005, r = -0.69, R-2 = 0.48) inverse, exponential relationship. A similar inverse relationship was obtained between low-strain E vs delta(h) (p < 0.0001, r = -0.93, R-2 = 0.86). Significance. The tensile properties of demineralized dentin are dependent on the hydrogen bonding ability of polar solvents (delta(h)). Solvents with low delta(h) values may permit new interpeptide H-bonding in collagen that increases its tensile properties. Solvents with high delta(h) values prevent the development of these new interpeptide H-bonds. (C) 2003 Academy of Dental Materials. Published by Elsevier Science Ltd. All rights reserved. C1 Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, Augusta, GA 30912 USA. USP, FOB, Bauru Sch Dent, Dept Operat Dent, BR-17043101 Bauru, SP, Brazil. Chonbuk Natl Univ, Sch Dent, Dept Conservat Dent, Chonju 561756, Chonbuk, South Korea. Univ Hong Kong, Fac Dent, Dept Conservat Dent, Hong Kong, Hong Kong, Peoples R China. USA, Dent Activ, Ft Gordon, GA 30905 USA. RP Pashley, DH (reprint author), Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, Augusta, GA 30912 USA. RI Rastelli, Marcio/B-8034-2011 FU NIDCR NIH HHS [DE06427] NR 25 TC 69 Z9 70 U1 0 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0109-5641 J9 DENT MATER JI Dent. Mater. PD JUL PY 2003 VL 19 IS 5 BP 347 EP 352 AR PII S0109-5641(02)00065-9 DI 10.1016/S0109-5641(02)00065-9 PG 6 WC Dentistry, Oral Surgery & Medicine; Materials Science, Biomaterials SC Dentistry, Oral Surgery & Medicine; Materials Science GA 680EX UT WOS:000182964300001 PM 12742428 ER PT J AU Xu, K Lee, U Zhang, SS Wood, M Jow, TR AF Xu, K Lee, U Zhang, SS Wood, M Jow, TR TI Chemical analysis of graphite/electrolyte interface formed in LiBOB-based electrolytes SO ELECTROCHEMICAL AND SOLID STATE LETTERS LA English DT Article ID LITHIUM-ION BATTERIES; GRAPHITE-ELECTRODES; BINARY CARBONATES; PHASE-DIAGRAMS; ANODES; MECHANISM; ETHYLENE AB To understand the source of thermal stability of LiBOB-based electrolyte in lithium-ion cells as well as its unique ability to stabilize graphitic anodes even in the strongly exfoliating solvent propylene carbonate (PC), the solid electrolyte interface on graphite formed by LiBOB-based electrolyte was investigated by X-ray photoelectron spectroscopy. Preliminary results show that, due to the BOB anion presence, the content of semicarbonate-like components in the graphite/electrolyte interface increases significantly, as indicated by the conspicuous peak located at 289 eV. These components, believed to originate from the oxalato moiety of the anion, are mainly responsible for the protection of graphitic anodes, either at elevated temperatures or in the presence of PC. (C) 2003 The Electrochemical Society. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 22 TC 100 Z9 103 U1 5 U2 45 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 SOUTH MAIN STREET, PENNINGTON, NJ 08534 USA SN 1099-0062 J9 ELECTROCHEM SOLID ST JI Electrochem. Solid State Lett. PD JUL PY 2003 VL 6 IS 7 BP A144 EP A148 DI 10.1149/1.1576049 PG 5 WC Electrochemistry; Materials Science, Multidisciplinary SC Electrochemistry; Materials Science GA 683LT UT WOS:000183151000006 ER PT J AU Torugsa, K Anderson, S Thongsen, N Sirisopana, N Jugsudee, A Junlananto, P Nitayaphan, S Sangkharomya, S Brown, AE AF Torugsa, K Anderson, S Thongsen, N Sirisopana, N Jugsudee, A Junlananto, P Nitayaphan, S Sangkharomya, S Brown, AE TI HIV epidemic among young Thai men, 1991-2000 SO EMERGING INFECTIOUS DISEASES LA English DT Article AB Characterization of the HIV epidemic in Thailand has benefited from the systematic testing of young men upon entry into the military. These data, which have shown that public health measures can reverse an HIV epidemic, have been reanalyzed with current geographic information systems methods. The resulting maps are, thus far, the best means of visualizing the geography of the dynamic HIV epidemic in Thailand. C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. SUNY Coll Cortland, Cortland, NY 13045 USA. Army Inst Pathol, Bangkok, Thailand. RP Brown, AE (reprint author), AFRIMS, Dept Retrovirol, APO, AP 96546 USA. NR 7 TC 10 Z9 11 U1 0 U2 0 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUL PY 2003 VL 9 IS 7 BP 881 EP 883 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 698WL UT WOS:000184022300022 PM 12890334 ER PT J AU Wang, ZL Wang, J Richter, H Howard, JB Carlson, J Levendis, YA AF Wang, ZL Wang, J Richter, H Howard, JB Carlson, J Levendis, YA TI Comparative study on polycyclic aromatic hydrocarbons, light hydrocarbons, carbon monoxide, and particulate emissions from the combustion of polyethylene, polystyrene, and poly(vinyl chloride) SO ENERGY & FUELS LA English DT Article ID SIMULATED INCINERATOR CONDITIONS; 2-STAGE COMBUSTION; PREMIXED ACETYLENE; PYROLYSIS; POLYMERS; SOOT; PLASTICS; FLAMES; POLY(STYRENE); DEGRADATION AB A laboratory-scale study was performed to compare the emissions of pollutants from the batch combustion of polystyrene (PS), polyethylene (PE), and poly(vinyl chloride) (PVC) and to examine the conditions that minimize them. Fixed beds of polymer particles were burned in a two-stage, preheated muffle furnace, using air at atmospheric pressure. The temperature of the primary furnace was varied over a range of 500-1000 degreesC, to identify its influence on the emission of pollutants. The combustion effluent was mixed with additional preheated air, channeled to a secondary muffle furnace (afterburner), which was operated at 1000 degreesC. Emissions of CO, CO2, light hydrocarbons, polycyclic aromatic hydrocarbons (PAHs), and particulates were monitored either on-line or by sample collection, followed by gas chromatographic analysis. Emission magnitudes and trends were found to be dependent on the type of the polymer burned. The combustion of PS produced the largest yields of PAHs and, especially, soot; PE produced the next-largest yields, followed by those from PVC. Emissions of CO were the highest from PE. As the temperature of the primary furnace increased, (a) particulate emissions from burning PS and PVC generally increased, while the trend of PE was ambivalent; (b) PAH emissions from PS and PE increased, whereas those from PVC rather decreased; and (c) the trends of CO with temperature were not monotonic. Additional treatment of the combustion effluent in the afterburner led to a decrease of particulate and PAH emissions from PS and PVC, whereas those from PE decreased at low primary furnace temperatures but increased at high temperatures. CO emissions from PVC decreased in the afterburner, but those from PS and PE generally increased. The trends of emissions monitored at the exit of the afterburner paralleled those at the exit of the primary furnace, as the temperature of the primary furnace was varied. Given the aforementioned trends, it appears that operation of the primary furnace at a relatively low temperature, in the vicinity of 600 degreesC, allows the afterburner to operate under conditions suitable for minimizing most emissions for all three polymers. A detailed kinetic model, comprised of more than 1100 chemical reactions, was used for the description of the afterburner. For this purpose, the afterburner was approximated as a steady-state plug-flow reactor. Measured concentrations of O-2, CO, CO2, light hydrocarbons, and PAHs at the inlet of the afterburner were integrated over the duration of the combustion event and used as input to the model calculation. Oxidation of PAHs, their conversion to soot, and the oxidation of soot were added to a previously developed model that included PAH formation. The model was tested for the case of PE incineration, and its predictions were qualitatively consistent with experimental data. C1 Northeastern Univ, Boston, MA 02115 USA. MIT, Cambridge, MA 02139 USA. USA, SBCCOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Boston, MA 02115 USA. NR 44 TC 38 Z9 38 U1 2 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 J9 ENERG FUEL JI Energy Fuels PD JUL-AUG PY 2003 VL 17 IS 4 BP 999 EP 1013 DI 10.1021/ef020269z PG 15 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 703LT UT WOS:000184281400031 ER PT J AU Yang, CP Suidan, MT Zhu, XQ Kim, BJ AF Yang, CP Suidan, MT Zhu, XQ Kim, BJ TI Comparison of single-layer and multilayer rotating drum biofilters for VOC removal SO ENVIRONMENTAL PROGRESS LA English DT Article; Proceedings Paper CT 5th USC-TRG Conference on Biofiltration CY OCT 31-NOV 01, 2002 CL NEWPORT BEACH, CALIFORNIA SP USC TRG ID BIOMASS CONTROL; PERFORMANCE; BIOFILTRATION; OPERATION AB Two types of rotating drum biofilters were tested to investigate the effect of medium configuration on biofilter performance for removing volatile organic compounds (VOCs) from waste gas streams. One was a single-layer biofilter that consisted of a thick layer of open-pore reticulated polyurethance foam media. The other was a multi-layer biofilter that used a set of four concentric thinner layers of the media. The effect of the two different media configurations was examined using diethyl ether as a model VOC at various organic loading rates. The reults showed that the multi-layer biofilter oculd maintain more stable and higher ether removal efficiencies at gas empty bed contact time (EBCT) of 30 s than the single-layer biofilter at gas EBCT of 90 s, and at organic loading rates ranging from 2.0 to 8.0 kg COD m(-3) day(-1) (32.1 to 128.4 g ether m(-3) h(-1)), all based on the medium volume. The multi-later biofilter also exhibited a more even more biomass distribution on the concentric surface at a medium depth than the single-layer biofilter, which suggests a reduced possibility of short-circuiting of gas streams and, consequently, better performance. C1 Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA. USA, Engn Res & Dev Ctr, Champaign, IL 61820 USA. RP Suidan, MT (reprint author), Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA. OI Yang, Chunping/0000-0003-3987-2722 NR 23 TC 28 Z9 36 U1 0 U2 5 PU AMER INST CHEMICAL ENGINEERS PI NEW YORK PA 3 PARK AVE, NEW YORK, NY 10016-5901 USA SN 0278-4491 J9 ENVIRON PROG JI Environ. Prog. PD JUL PY 2003 VL 22 IS 2 BP 87 EP 94 DI 10.1002/ep.670220210 PG 8 WC Engineering, Environmental; Engineering, Chemical; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 719VP UT WOS:000185226000004 ER PT J AU Newman, JA Riddell, WT Piascik, RS AF Newman, JA Riddell, WT Piascik, RS TI A threshold fatigue crack closure model: Part I - model development SO FATIGUE & FRACTURE OF ENGINEERING MATERIALS & STRUCTURES LA English DT Article DE crack tip; fatigue crack closure; oxide; plasticity; roughness; threshold ID STRESS INTENSITIES; THEORETICAL-MODEL; GROWTH; DISLOCATION; ROUGHNESS; ALUMINUM; PROPAGATION; ENVIRONMENT; STRENGTH; BEHAVIOR AB A fatigue crack closure model is developed that includes the effects of, and interactions between, the three closure mechanisms most likely to occur at threshold; plasticity, roughness, and oxide. This model, herein referred to as the CROP model (for Closure, Roughness, Oxide, and Plasticity), also includes the effects of out-of-plane cracking and multi-axial loading. These features make the CROP closure model uniquely suited for, but not limited to, threshold applications. Rough cracks are idealized here as two-dimensional sawtooths, whose geometry induces mixed-mode crack-tip stresses. Continuum mechanics and crack-tip dislocation concepts are combined to relate crack face displacements to crack-tip loads. Geometric criteria are used to determine closure loads from crack-face displacements. Finite element results, used to verify model predictions, provide critical information about the locations where crack closure occurs. The CROP model is verified with experimental data in part II of this paper. C1 USA, Res Lab, Vehicle Technol Directorate, Hampton, VA 23681 USA. Volpe Natl Transportat Syst Ctr, Cambridge, MA 02142 USA. NASA, Langley Res Ctr, Met & Thermal Struct Branch, Hampton, VA 23681 USA. Virginia Tech, Blacksburg, VA USA. RP Newman, JA (reprint author), USA, Res Lab, Vehicle Technol Directorate, Hampton, VA 23681 USA. NR 48 TC 11 Z9 11 U1 1 U2 4 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 8756-758X J9 FATIGUE FRACT ENG M JI Fatigue Fract. Eng. Mater. Struct. PD JUL PY 2003 VL 26 IS 7 BP 603 EP 614 DI 10.1046/j.1460-2695.2003.00660.x PG 12 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 692XW UT WOS:000183686400004 ER PT J AU Newman, JA Riddell, WT Piascik, RS AF Newman, JA Riddell, WT Piascik, RS TI A threshold fatigue crack closure model: Part II - experimental verification SO FATIGUE & FRACTURE OF ENGINEERING MATERIALS & STRUCTURES LA English DT Article DE crack tip; fatigue crack closure; oxide; plasticity; roughness; threshold ID FRACTURE SURFACE-ROUGHNESS; THEORETICAL-MODEL; GROWTH; ALUMINUM; BEHAVIOR AB Predictions from an analytical model that considers contributions and interactions between plasticity, roughness, and oxide induced crack closure are presented and compared with experimental data. The analytical model is shown to correctly predict the combined influences of crack roughness, oxide debris, and plasticity in the near-threshold regime. Furthermore, analytical results indicate closure mechanisms interact in a non-linear manner such that the total amount of closure is not the sum of closure contributions for each mechanism. C1 USA, Res Lab, Vehicle Technol Directorate, Hampton, VA 23681 USA. Volpe Natl Transportat Syst Ctr, Cambridge, MA 02142 USA. NASA, Langley Res Ctr, Met & Thermal Struct Branch, Hampton, VA 23681 USA. Virginia Tech, Blacksburg, VA USA. RP Newman, JA (reprint author), USA, Res Lab, Vehicle Technol Directorate, Hampton, VA 23681 USA. NR 31 TC 5 Z9 5 U1 0 U2 1 PU BLACKWELL PUBLISHING LTD PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND SN 8756-758X J9 FATIGUE FRACT ENG M JI Fatigue Fract. Eng. Mater. Struct. PD JUL PY 2003 VL 26 IS 7 BP 615 EP 625 DI 10.1046/j.1460-2695.2003.00635.x PG 11 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 692XW UT WOS:000183686400005 ER PT J AU Dalton, SR Fillman, EP Altman, CE Gardner, TL Davis, TL Bastian, BC Libow, LF Elston, DM AF Dalton, SR Fillman, EP Altman, CE Gardner, TL Davis, TL Bastian, BC Libow, LF Elston, DM TI Atypical junctional melanocytic proliferations in benign lichenoid keratosis SO HUMAN PATHOLOGY LA English DT Article DE atypical junctional melanocytic proliferation; malignant melanoma in situ; lichenoid tissue reaction; benign lichenoid keratosis; regression; fluorescent in situ hybridization ID MELANOMA IN-SITU; SUN-DAMAGED SKIN; MALIGNANT-MELANOMA; LENTIGO MALIGNA; NEVI AB Melanocytic lesions with lichenoid regression may mimic a benign lichenoid keratosis (BLK) histologically. A total of 336 BLKs were reviewed and deeper sections obtained to determine the frequency of this phenomenon. Two cases (0.6%) showed at least I melanocytic nest or junctional multinucleated melanocyte (starburst melanocyte) on deeper sections confirmed by MART-1 immunostaining. Both of these cases demonstrated solar elastosis, and I case had an effaced rete ridge pattern. Not included in the histological study are 5 additional cases in which the initial slide showed only lichenoid dermatitis, but deeper sections obtained before to the initial sign-out revealed a melanocytic proliferation. These 5 cases would have been signed out as "consistent with BLK" if deeper sections had not been obtained. Fluorescent in situ hybridization (FISH) was performed on 3 cases; in each case, the melanocytes demonstrated a loss of chromosome 9p21 DNA copy number. The finding of nests of genetically altered melanocytes on severely sun-damaged skin strongly suggests that these cases represent lichenoid regression of melanoma in situ. Pathologists should approach a diagnosis of BLK cautiously in the setting of severely sun-damaged skin. (C) 2003 Elsevier Inc. All rights reserved. C1 Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. Geisinger Med Ctr, Dept Pathol, Danville, PA 17822 USA. Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Dermatol, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX USA. S Texas Dermatopathol, San Antonio, TX USA. Univ Calif San Francisco, Ctr Comprehens Canc, Dept Dermatol, San Francisco, CA USA. Univ Calif San Francisco, Ctr Comprehens Canc, Dept Pathol, San Francisco, CA USA. RP Elston, DM (reprint author), Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. NR 14 TC 10 Z9 10 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD JUL PY 2003 VL 34 IS 7 BP 706 EP 709 DI 10.1016/S0046-8177(03)00234-X PG 4 WC Pathology SC Pathology GA 702XB UT WOS:000184249100011 PM 12874767 ER PT J AU Rasch, R Kott, A Forbus, KD AF Rasch, R Kott, A Forbus, KD TI Incorporating AI into military decision making: An experiment SO IEEE INTELLIGENT SYSTEMS LA English DT Article C1 USA, Washington, DC USA. BBN Technol, Pittsburgh, PA USA. Northwestern Univ, Dept Comp Sci, Evanston, IL 60201 USA. RP Rasch, R (reprint author), HHC, TSC 19, Unit 15015, Box 883, APO, AP 96218 USA. RI Forbus, Kenneth/B-7146-2009 NR 12 TC 5 Z9 5 U1 1 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1094-7167 J9 IEEE INTELL SYST JI IEEE Intell. Syst. PD JUL-AUG PY 2003 VL 18 IS 4 BP 18 EP 26 DI 10.1109/MIS.2003.1217624 PG 9 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 705VL UT WOS:000184416600006 ER PT J AU Wu, RB Gu, KL Li, J Bradley, M Habersat, J Maksymonko, G AF Wu, RB Gu, KL Li, J Bradley, M Habersat, J Maksymonko, G TI Propagation velocity uncertainty on GPR SAR processing SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID MINE DETECTION; RADAR AB To detect buried landmines, Planning Systems Incorporated (PSI) has developed a ground-penetrating synthetic aperture radar (GPSAR) system. Since the electromagnetic wave propagation velocity in the soil depends on many factors, velocity uncertainty is inevitable. However, we have observed that, unlike conventional airborne/spaceborne synthetic aperture radar (SAR) systems, the PSI GPSAR system is very robust against the velocity uncertainty under mild conditions. Theoretical analysis is provided to explain this observation. Although our discussion is based on the PSI GPSAR system, it applies to other GPR-based (ground-penetrating radar) landmine detection systems as well. C1 Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. Planning Syst Inc, Long Beach, MI USA. USA, Night Vis Sensor Directories, Ft Belvoir, VA USA. RP Wu, RB (reprint author), Civil Aviat Univ China, Coll Air Traff Management, Dept Commun Engn, Tianjin, Peoples R China. NR 9 TC 4 Z9 8 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 2003 VL 39 IS 3 BP 849 EP 861 DI 10.1109/TAES.2003.1238741 PG 13 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 728NJ UT WOS:000185723000010 ER PT J AU Yang, JSS Yang, XM Turner, JA Kosinski, JA Pastore, RA AF Yang, JSS Yang, XM Turner, JA Kosinski, JA Pastore, RA TI Two-dimensional equations for electroelastic plates with relatively large shear deformations SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID TRAPPED-ENERGY RESONATORS; HIGH-FREQUENCY VIBRATIONS; THICKNESS-SHEAR AB A set of two-dimensional, nonlinear equations for electroelastic plates in moderately large thickness-shear deformations is obtained from the variational formulation of the three-dimensional equations of nonlinear electroelasticity by expanding the mechanical displacement vector and the electric potential into power series in the plate thickness coordinate. As an example, the equations are used to study nonlinear thickness-shear vibrations of a quartz plate driven by an electrical voltage. Nonlinear electrical current amplitude-frequency behavior near resonance is obtained. The equations and results are useful in the study and design of piezoelectric crystal resonators and the measurement of nonlinear material constants of electroelastic materials. C1 Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. USA, CECOM Attn, AMSEL, RD,IW,S, Ft Monmouth, NJ 07703 USA. RP Yang, JSS (reprint author), Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. RI Turner, Joseph/F-5165-2010 NR 19 TC 15 Z9 15 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JUL PY 2003 VL 50 IS 7 BP 765 EP 772 DI 10.1109/TUFFC.2003.1214496 PG 8 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 702EC UT WOS:000184211100002 PM 12894910 ER PT J AU Wei, J Goldberg, MB Burland, V Venkatesan, MM Deng, W Fournier, G Mayhew, GF Plunkett, G Rose, DJ Darling, A Mau, B Perna, NT Payne, SM Runyen-Janecky, LJ Zhou, S Schwartz, DC Blattner, FR AF Wei, J Goldberg, MB Burland, V Venkatesan, MM Deng, W Fournier, G Mayhew, GF Plunkett, G Rose, DJ Darling, A Mau, B Perna, NT Payne, SM Runyen-Janecky, LJ Zhou, S Schwartz, DC Blattner, FR TI Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T (vol 71, pg 2775, 2003) SO INFECTION AND IMMUNITY LA English DT Correction C1 Univ Wisconsin, Genet Lab, Madison, WI 53706 USA. Univ Wisconsin, Genome Ctr Anim Hlth & Biol Sci, Madison, WI 53706 USA. Univ Wisconsin, Genome Ctr, Madison, WI 53706 USA. Univ Wisconsin, Dept Chem, Madison, WI 53706 USA. Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA. Walter Reed Army Inst Res, Dept Enter Infect, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. Univ Texas, Inst Mol & Cellular Biol, Austin, TX 78712 USA. RP Wei, J (reprint author), Univ Wisconsin, Genet Lab, Madison, WI 53706 USA. NR 1 TC 6 Z9 6 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 2003 VL 71 IS 7 BP 4223 EP 4223 DI 10.1128/IAI.71.7.4223.2003 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 694WB UT WOS:000183797200078 ER PT J AU Knapik, JJ Hauret, KG Arnold, S Canham-Chervak, M Mansfield, AJ Hoedebecke, EL McMillian, D AF Knapik, JJ Hauret, KG Arnold, S Canham-Chervak, M Mansfield, AJ Hoedebecke, EL McMillian, D TI Injury and fitness outcomes during implementation of physical readiness training SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE military personnel; physical education training; gymnastics; demography; muscle contraction ID EXERCISE-RELATED INJURIES; STRESS-FRACTURES; RUNNING INJURIES; ARMY RECRUITS; RISK-FACTORS; YOUNG MEN; PROGRAM; CAPABILITY; PREVENTION; ENDURANCE AB This study examined injury and physical fitness outcomes in Basic Combat Training (BCT) during implementation of Physical Readiness Training (PRT). PRT is the U.S. Army's emerging physical fitness training program. An experimental group (EG, n = 1284), which implemented the PRT program, was compared to a control group (CG, n = 1296), which used a traditional BCT physical training program during the 9-week BCT cycle. Injury cases were obtained from recruit medical records and physical fitness was measured using the U.S. Army Physical Fitness Test (APFT, consisting of push-ups, sit-ups and a two-mile run). Injury rates were examined using Cox regression after controlled for initial group differences in demographics, fitness and other variables. Compared to the EG, the adjusted relative risk of a time-loss overuse injury in the CG was 1.5 (95% confidence interval [CI]=1.0-2.1, p<0.01) for men, and 1.4 (95% CI=1.1 - 1.8, p < 0.01) for women. There were no differences between groups for traumatic injuries. On the first administration of the final APFT, the EG had a greater proportion of recruits passing the test than the CG (men: 85 % vs. 81 %, p = 0.04; women: 80 % vs. 70%, p < 0.01). After all APFT retakes, the EG had significantly fewer APFF failures than the CG among the women (1.6% vs. 4.6%, p < 0.01) but not the men (1.6% vs. 2.8 %, p = 0.18); the gender-combined EG had a higher pass rate (1.6 % vs. 3.7 %, p < 0.01). Overall, the PRT program reduced overuse injuries and allowed a higher success rate on the APFT. C1 USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. USA, Phys Fitness Sch, Ft Benning, GA USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. NR 51 TC 48 Z9 50 U1 1 U2 7 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD JUL PY 2003 VL 24 IS 5 BP 372 EP 381 PG 10 WC Sport Sciences SC Sport Sciences GA 709CU UT WOS:000184607800011 PM 12868050 ER PT J AU Bailey, MB Kreider, JF AF Bailey, MB Kreider, JF TI Creating an automated chiller fault detection and diagnostics tool using a data fault library SO ISA TRANSACTIONS LA English DT Article DE software; DDC; experimental research ID PERFORMANCE AB Reliable, automated detection and diagnosis of abnormal behavior within vapor compression refrigeration cycle (VCR-C) equipment is extremely desirable for equipment owners and operators. The specific type of VCRC equipment studied in this paper is a 70-ton helical rotary, air-cooled chiller. The fault detection and diagnostic (FDD), tool developed as part of this research analyzes chiller operating data and detects faults through recognizing trends or patterns existing within the data [1]. The FDD method incorporates a neural network (NN) classifier to infer the current state given a vector of observables. Therefore the FDD method relies upon the availability of normal and fault empirical data for training purposes and therefore a fault library of empirical data is assembled [2]. This paper presents procedures for conducting sophisticated fault experiments on chillers that simulate air-cooled condenser, refrigerant, and oil related faults. The experimental processes described here are not well documented in literature and therefore will provide the interested reader with a useful guide. In addition, the authors provide evidence, based on both thermodynamics and empirical data analysis, that chiller performance is significantly degraded during fault operation. The chiller's performance degradation is successfully detected and classified by the NN FDD classifier as discussed in the paper's final section. (C) 2003 ISA-The Instrumentation, Systems, and Automation Society. C1 US Mil Acad, Dept Civil & Mech Engn, W Point, NY 10996 USA. Univ Colorado, Joint Ctr Energy Management, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. RP Bailey, MB (reprint author), US Mil Acad, Dept Civil & Mech Engn, W Point, NY 10996 USA. NR 16 TC 5 Z9 5 U1 3 U2 3 PU I S A-THE INSTRUMENTATION SYSTEMS AUTOMATION SOC PI RES TRIANGLE PK PA 67 ALEXANDER DR, PO BOX 12277, RES TRIANGLE PK, NC 27709 USA SN 0019-0578 J9 ISA T JI ISA Trans. PD JUL PY 2003 VL 42 IS 3 BP 485 EP 495 DI 10.1016/S0019-0578(07)60149-9 PG 11 WC Automation & Control Systems; Engineering, Multidisciplinary; Instruments & Instrumentation SC Automation & Control Systems; Engineering; Instruments & Instrumentation GA 697FF UT WOS:000183931000012 PM 12858981 ER PT J AU Polyakov, AY Smirnov, NB Govorkov, AV Ip, K Overberg, ME Heo, YW Norton, DP Pearton, SJ Luo, B Ren, F Zavada, JM AF Polyakov, AY Smirnov, NB Govorkov, AV Ip, K Overberg, ME Heo, YW Norton, DP Pearton, SJ Luo, B Ren, F Zavada, JM TI Hydrogen plasma treatment effects on electrical and optical properties of n-ZnO SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; ZINC-OXIDE; PERSISTENT PHOTOCONDUCTIVITY; SHALLOW DONOR; DEEP LEVELS; FILMS; ACCEPTOR; CONDUCTIVITY; LUMINESCENCE; CRYSTALS AB The effects of hydrogen plasma treatment on high-quality bulk n-ZnO crystals were studied. It is shown that after plasma exposure at 200 degreesC for 0.5 h the hydrogen penetrates into the material down to about 20 mum and shows concentrations close to 10(17) cm(-3) in that region. The incorporation of this hydrogen coincides with an increase in the shallow donor concentration to about the same level as the concentration of hydrogen. In contrast to that in most other semiconductor materials, hydrogen plasma treatment of ZnO is shown to increase the concentration of the already existing electron and hole traps and to introduce electron traps near 0.55 eV, earlier observed in proton irradiated samples. The effect is at least partially due to the surface damage caused by plasma exposure. Despite this increase in the density of deep traps, the luminescence intensity in the near band-edge region is shown to increase down to the depth corresponding to the hydrogen penetration depth in the material. (C) 2003 American Institute of Physics. C1 Inst Rare Met, Moscow 119017, Russia. Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Polyakov, AY (reprint author), Inst Rare Met, B Tolmachevsky Per 5, Moscow 119017, Russia. RI Smirnov, Nickolai/K-8935-2015 OI Smirnov, Nickolai/0000-0002-4993-0175 NR 37 TC 51 Z9 54 U1 0 U2 12 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 1 PY 2003 VL 94 IS 1 BP 400 EP 406 DI 10.1063/1.1579114 PG 7 WC Physics, Applied SC Physics GA 692CN UT WOS:000183642900055 ER PT J AU Convertino, VA AF Convertino, VA TI Evidence for altered alpha-adrenoreceptor responsiveness after a single bout of maximal exercise SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE autonomic function; sympathetic; heart rate; blood pressure; baroreflex; vascular resistance ID ORTHOSTATIC INTOLERANCE; RESPONSES; SPACEFLIGHT AB We studied hemodynamic responses to alpha- and beta-receptor agonists in eight men to test the hypothesis that adrenoreceptor responsiveness is altered within 24 h of the performance of maximal exercise. Adrenoreceptor responsiveness was tested under two experimental conditions (with and without maximal exercise). Adrenoreceptor tests were performed 24 h after each subject performed graded upright cycle ergometry to volitional exhaustion. The 2 test days (experimental conditions) were separated by at least 1 wk, and the order of exercise and no-exercise conditions was counterbalanced. Steady-state graded infusions of phenylephrine (PE) and isoproterenol (Iso) were used to assess alpha- and beta-adrenoreceptor responsiveness, respectively. Slopes calculated from linear regressions between Iso and PE doses and changes in heart rate, blood pressure, and leg vascular resistance for each subject were used as an index of alpha- and beta-adrenoreceptor responsiveness. The slope of the relationship between heart rate and Iso with maximal exercise was 1,773 +/- 164 beats.mug(-1).kg(-1).min(-1) compared with 1,987 +/- 142 beats.mug(-1).kg(-1).min(-1) without exercise (P = 0.158), whereas the slopes of the relationship between vascular resistance to Iso were -438 +/- 123 peripheral resistance units (PRU).mug(-1).kg(-1).min(-1) with maximal exercise and -429 +/- 105 .mug(-1.)kg(-1).min(-1) without exercise (P = 0.904). Maximal exercise was associated with greater (P < 0.05) vascular resistance (15.1 +/- 2.8 PRU.μg(-1).kg(-1).min(-1)) and mean arterial blood pressure (15.8 +/- 2.1 mmHg.μg(-1).kg(-1).min(-1)) responses to PE infusion compared with no exercise (9.0 +/- 2.0 PRU.μg(-1).kg(-1).min(-1) and 10.9 +/- 2.0 mmHg.μg(-1).kg(-1).min(-1), respectively). These results provide evidence that a single bout of maximal exercise increases α(1)-adrenoreceptor responsiveness within 24 h without affecting β-cardiac and vascular adrenoreceptor responses. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Profess Performance Dev Grp Inc, San Antonio, TX 78240 USA. Rothe Dev Inc, San Antonio, TX 78222 USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. NR 22 TC 5 Z9 5 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 2003 VL 95 IS 1 BP 192 EP 198 DI 10.1152/japplphysiol.00123.2003 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 687AY UT WOS:000183354700025 PM 12679359 ER PT J AU Platteborze, PL AF Platteborze, PL TI Effects of sulfur mustard on transcription in human epidermal keratinocytes: Analysis by mRNA differential display SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE differential display; transcription; genes; human epidermal keratinocytes; sulfur mustard ID NAD+ LEVELS; CLONING; PROTEIN; DNA; NICOTINAMIDE; EXPRESSION; POLYMERASE; TOXICITY; PATHWAY; GADD45 AB This study examines the transcriptional response of human epidermal keratinocytes (HEK) to sulfur mustard (HD) in order to gain a better understanding of the intracellular events that result in cytotoxicity. Differential display polymerase chain reaction technology was used to examine the relative transcriptional activity of healthy cells to those exposed to subvesicating or vesicating concentrations of HD for 4 h. Approximately 2% of the HEK transcriptome had altered expression. Sixty of the most prominently altered transcripts were characterized. Important upregulated genes include NADH dehydrogenase III, GADD45 and ubiquitin. Key downregulated genes include type I keratin 14, alpha-enolase and caltractin. Many of the identified transcripts protein products presently do not have an assigned function and eleven transcripts were unidentifiable. These transcriptional alterations provide one of the first molecular insights into the intracellular events induced by HD. Published in 2003 by John Wiley Sons, Ltd. C1 USA, Med Res Inst Chem Def, Div Pharmacol, Aberdeen Proving Ground, MD 21010 USA. RP Platteborze, PL (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Bldg 1425, Ft Detrick, MD 21702 USA. NR 41 TC 7 Z9 9 U1 4 U2 5 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JUL-AUG PY 2003 VL 23 IS 4 BP 249 EP 254 DI 10.1002/jat.914 PG 6 WC Toxicology SC Toxicology GA 706YY UT WOS:000184483700008 PM 12884408 ER PT J AU Petty, DG Getsinger, KD Woodburn, KB AF Petty, DG Getsinger, KD Woodburn, KB TI A review of the aquatic environmental fate of triclopyr and its major metabolites SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE Garlon 3A; renovate 3; metabolite; toxicology; aquatic plant control; herbicide dissipation ID RHODAMINE WT DYE; TRIETHYLAMINE SALT; LAKE MINNETONKA; DISSIPATION; TOXICITY; 3,5,6-TRICHLORO-2-PYRIDINOL AB The triethylamine salt formulation of triclopyr was recently registered for use in aquatic sites by the U.S. Environmental Protection Agency for selective control of invasive aquatic and wetland weed species. Research shows that this herbicide and its metabolites have an environmentally compatible degradation scenario, an excellent toxicological profile, and the ability to selectively control a variety of exotic weed species, making it a valuable tool for restoring and managing aquatic ecosystems. Laboratory studies show that photolytic processes rapidly degrade triclopyr, indicating a major role in dissipation from aquatic sites. However, subsequent field studies indicate that photolysis has a more limited role in the aquatic degradation, likely due to sunlight attenuation in natural waters, and show that metabolic degradation processes assume a more important role. Laboratory investigations show aerobic and anaerobic degradation in hydrosoils is a slower process, and hydrolysis plays a minor role in triclopyr degradation. Field studies conducted in California, Georgia, Minnesota, Missouri, Texas and Washington have shown triclopyr and its TCP and TMP metabolites dissipated from water with half-lives ranging from 0.5 to 7.5, 4.2 to 10.0, and 4.0 to 8.8 days, respectively. Sediment dissipation half-lives ranged from 2.7 to 13.3 days for the same compounds. Half-lives for fish and shell fish ranged from 1.6 to 15.1 days. Results from laboratory and field studies indicate dissipation rates of the parent triclopyr and its metabolites are similar and relatively rapid. C1 NDR Res, Plainfield, IN 46168 USA. USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. Dow Chem Co USA, Toxicol Environm Res & Consulting Lab, Midland, MI 48674 USA. RP Petty, DG (reprint author), NDR Res, 710 Hanna St, Plainfield, IN 46168 USA. NR 37 TC 15 Z9 15 U1 3 U2 8 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2003 VL 41 BP 69 EP 75 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 766HX UT WOS:000188371900002 ER PT J AU Kirk, JP Socha, RC AF Kirk, JP Socha, RC TI Longevity and persistence of triploid grass carp stocked into the santee cooper reservoirs of South Carolina SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID RIVER AB This study evaluated longevity and population persistence of 768,500 triploid grass carp (Ctenopharyngodon idella Valenciennes) stocked in the 70,000-ha Santee Cooper system in South Carolina from 1989 through 1996 to control hydrilla (Hydrilla verticillata (L.f.) Royle). Collected from 1998 through 2002, the oldest of 477 fish were age 11. Total annual mortality rates ranged from 22% to 39% meaning 10% of a cohort could persist for 5 to 9 years. Longevity and persistence measured in this study demonstrate that benefits of aquatic plant control and risks to non-target organisms need to be carefully balanced. Annual stocking of as many as 150,000 could potentially leave numerous fish in this system for almost a decade. Conversely, control of hydrilla, achieved since 1997, is unlikely to last more than few more years. C1 USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. USA Dist, Charleston, SC 29403 USA. RP Kirk, JP (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 22 TC 10 Z9 10 U1 1 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2003 VL 41 BP 90 EP 92 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 766HX UT WOS:000188371900005 ER PT J AU Getsinger, KD Sprecher, SL Smagula, AP AF Getsinger, KD Sprecher, SL Smagula, AP TI Effects of triclopyr on variable-leaf watermilfoil SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID EURASIAN WATERMILFOIL; HERBICIDE TRICLOPYR C1 USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. New Hampshire Dept Environm Serv, Water Div, Concord, NH 03302 USA. RP Getsinger, KD (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Hall Ferry Rd, Vicksburg, MS 39180 USA. EM Kurt.D.Getsinger@erdc.usace.army.mil NR 18 TC 7 Z9 8 U1 1 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2003 VL 41 BP 124 EP 126 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 766HX UT WOS:000188371900011 ER PT J AU Glomski, LAM Nelson, LS Skogerboe, JG AF Glomski, LAM Nelson, LS Skogerboe, JG TI Clearigate((R)) treatments for control of giant salvinia SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID MOLESTA C1 Purdue Univ, Dept Bot & Plant Pathol, W Lafayette, IN 47907 USA. USA, Waterways Expt Stn, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. USA, Engineer Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. RP Nelson, LS (reprint author), Purdue Univ, Dept Bot & Plant Pathol, 915 W State St, W Lafayette, IN 47907 USA. EM nelsonl@wes.army.mil NR 9 TC 3 Z9 3 U1 0 U2 0 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2003 VL 41 BP 127 EP 129 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 766HX UT WOS:000188371900012 ER PT J AU Werrlein, RJ Madren-Whalley, JS AF Werrlein, RJ Madren-Whalley, JS TI Multiphoton microscopy: an optical approach to understanding and resolving sulfur mustard lesions SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE multiphoton microscopy; human epidermis; adhesion complex; keratinocytes; sulfur mustard; keratin 14 cytoskeleton; alpha(6)beta(4) integrin; laminin 5 ID EPIDERMOLYSIS-BULLOSA SIMPLEX; INTERMEDIATE FILAMENT PROTEIN; ALPHA(6)BETA(4) INTEGRIN; SIGNAL-TRANSDUCTION; GENETIC-DISORDERS; CELL-ADHESION; XVII COLLAGEN; HEMIDESMOSOMES; CYTOSKELETON; PLECTIN AB Sulfur mustard (SM; 2,2'-dichloroethyl sulfide) is a percutaneous alkylating agent first used as a chemical weapon at Ypres, Belgium, in World War 1. Despite its well-documented history, the primary lesions effecting dermal-epidermal separation and latent onset of incapacitating blisters remain poorly understood. By immunofluorescent imaging of human epidermal keratinocytes (HEK) and epidermal tissues exposed to SM (400 muM for 5 min), we have amassed unequivocal evidence that SM disrupts adhesion complex molecules, which are also disrupted by epidermolysis bullosa-type blistering diseases of the skin. Images of keratin 14 (K14) in control cells showed tentlike filament networks linking the HEK's basolateral anchoring sites to the dorsal surface of its nuclei. Images from 6-h postexposure profiles revealed early disruption (less than or equal to1 h) and progressive collapse of the K14 cytoskeleton. Collapse involved focal erosions, loss of functional asymmetry, and displacement of nuclei beneath a mat of jumbled filaments. In complementary studies, I-h images showed statistically significant (p<0.01) decreases of 25 to 30% in emissions from labeled alpha(6)beta(4) integrin and laminin 5, plus disruption of their receptor-ligand organization. Results indicate that SM alkylation destabilizes dermal-epidermal attachments and potentiates vesication by disrupting adhesion complex molecules and associated signaling mechanisms required for their maintenance and repair. (C) 2003 Society of Photo-Optical Instrumentation Engineers. C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Werrlein, RJ (reprint author), USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 46 TC 13 Z9 13 U1 0 U2 2 PU SPIE-INT SOCIETY OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 J9 J BIOMED OPT JI J. Biomed. Opt. PD JUL PY 2003 VL 8 IS 3 BP 396 EP 409 DI 10.1117/1.1584687 PG 14 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA 709CD UT WOS:000184606400011 PM 12880345 ER PT J AU Hurtle, W Lindler, L Fan, W Shoemaker, D Henchal, E Norwood, D AF Hurtle, W Lindler, L Fan, W Shoemaker, D Henchal, E Norwood, D TI Detection and identification of ciprofloxacin-resistant Yersinia pestis by denaturing high-performance liquid chromatography SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SINGLE-NUCLEOTIDE POLYMORPHISMS; ESCHERICHIA-COLI; DNA GYRASE; FLUOROQUINOLONE RESISTANCE; QUINOLONE RESISTANCE; DETERMINING REGION; GENE; MUTATIONS; HPLC; PCR AB Denaturing high-performance liquid chromatography (DHPLC) has been used extensively to detect genetic variation. We used this method to detect and identify Yersinia pestis KIM5 ciprofloxacin-resistant isolates by analyzing the quinolone resistance-determining region (QRDR) of the gyrase A gene. Sequencing of the Y. pestis KIM5 strain gyrA QRDR from 55 ciprofloxacin-resistant isolates revealed five mutation types. We analyzed the gyrA QRDR by DHPLC to assess its ability to detect point mutations and to determine whether DHPLC peak profile analysis could be used as a molecular fingerprint. In addition to the five mutation types found in our ciprofloxacin-resistant isolates, several mutations in the QRDR were generated by site-directed mutagenesis and analyzed to further evaluate this method for the ability to detect QRDR mutations. Furthermore, a blind panel of 42 samples was analyzed by screening for two mutant types to evaluate the potential diagnostic value of this method. Our results showed that DHPLC is an efficient method for detecting mutations in genes that confer antibiotic resistance. C1 USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. Clin Res Management, N Royalton, OH USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Norwood, D (reprint author), USA, Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 21702 USA. NR 41 TC 14 Z9 21 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 2003 VL 41 IS 7 BP 3273 EP 3283 DI 10.1128/JCM.41.7.3273-3283.2003 PG 11 WC Microbiology SC Microbiology GA 701MF UT WOS:000184170800072 PM 12843075 ER PT J AU Teel, LD Steinberg, BR Aronson, NE O'Brien, AD AF Teel, LD Steinberg, BR Aronson, NE O'Brien, AD TI Shiga toxin-producing Escherichia coli-associated kidney failure in a 40-year-old patient and late diagnosis by novel bacteriologic and toxin detection methods SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; HEMOLYTIC-UREMIC SYNDROME; MONOCLONAL-ANTIBODIES; 2 COPIES; O157-H7; DEATH AB Infection with Shiga toxin-producing Escherichia coli (STEC) is the most common cause of kidney failure in children. High morbidity is also associated with infections in the elderly. We describe STEC-associated kidney failure in a 40-year-old patient, including the methods used to identify STEC a month after disease onset. C1 Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Teel, LD (reprint author), Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. OI O'Brien, Alison/0000-0002-1315-3204 NR 15 TC 7 Z9 7 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 2003 VL 41 IS 7 BP 3438 EP 3440 DI 10.1128/JCM.41.7.3438-3440.2003 PG 3 WC Microbiology SC Microbiology GA 701MF UT WOS:000184170800112 PM 12843115 ER PT J AU Ly, JQ Bui-Mansfield, LT SanDiego, JW Beaman, NA Ficke, JR AF Ly, JQ Bui-Mansfield, LT SanDiego, JW Beaman, NA Ficke, JR TI Neural fibrolipoma of the foot SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE neural fibrolipoma; MR imaging; lipofibromatous hamartoma; perineural lipoma AB Neural fibrolipoma is a benign tumor comprised of hypertrophied fibrofatty tissue with intermixed nerve tissue. We present the case of a neural fibrolipoma of the foot that underwent above-ankle amputation and review the characteristic features of this unique form of localized gigantism. C1 Wilford Hall USAF Med Ctr, Dept Radiol, San Antonio, TX 78236 USA. USUHS, Dept Radiol, Bethesda, MD USA. Wake Forest Univ, Bowman Gray Sch Med, Dept Radiol, Winston Salem, NC USA. Wilford Hall USAF Med Ctr, Dept Pathol, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Dept Pathol, San Antonio, TX USA. Brooke Army Med Ctr, Dept Orthoped Surg, San Antonio, TX USA. RP Ly, JQ (reprint author), Wilford Hall USAF Med Ctr, Dept Radiol, San Antonio, TX 78236 USA. NR 4 TC 5 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD JUL-AUG PY 2003 VL 27 IS 4 BP 639 EP 640 DI 10.1097/00004728-200307000-00035 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 707UL UT WOS:000184528200035 PM 12886159 ER PT J AU Sivananthan, S Dhar, NK AF Sivananthan, S Dhar, NK TI Special issue on 2002 US Workshop Physics and Chemistry of II-VI Materials - Foreword SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Editorial Material C1 Univ Illinois, Chicago, IL USA. USA, Res Lab, Adelphi, MD USA. RP Sivananthan, S (reprint author), Univ Illinois, Chicago, IL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2003 VL 32 IS 7 BP 587 EP 587 DI 10.1007/s11664-003-0036-z PG 1 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 703LW UT WOS:000184281700001 ER PT J AU Benson, JD Stoltz, AJ Boyd, PR Martinka, M Varesi, JB Almeida, LA Olver, KA Kaleczyc, AW Johnson, SM Radford, WA Dinan, JH AF Benson, JD Stoltz, AJ Boyd, PR Martinka, M Varesi, JB Almeida, LA Olver, KA Kaleczyc, AW Johnson, SM Radford, WA Dinan, JH TI Lithography factors that determine the aspect ratio of electron cyclotron resonance plasma etched HgCdTe trenches SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT Workshop on Physics and Chemistry of II-VI Materials CY NOV 13-15, 2002 CL SAN DIEGO, CALIFORNIA SP USA, CECOM Night Vis & Elect Sensors Directorate, USA, Res Lab, USA, SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Miner, Mat & Mat Soc DE electron cyclotron resonance; etch bias; anisotropy; aspect ratio; HgCdTe ID PHOTORESIST-FEATURE GEOMETRY; DETECTORS; SILICON; GROWTH AB Factors that affect width and aspect ratio in electron cyclotron resonance (ECR) etched HgCdTe trenches are investigated. The ECR etch bias and anisotropy are determined by photoresist feature erosion rate. The physical characteristics of the trenches are attributed to a combination of photoresist feature geometry and ECR plasma etch chemistry. This knowledge has led to production of trenches suitable for two-color, 20 mum pitch detectors. C1 USA, CECOM, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. USA, Res Lab, Adelphi, MD 20873 USA. Raytheon Infrared Operat, Goleta, CA 93117 USA. RP Benson, JD (reprint author), USA, CECOM, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 14 TC 11 Z9 11 U1 0 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2003 VL 32 IS 7 BP 686 EP 691 DI 10.1007/s11664-003-0053-y PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 703LW UT WOS:000184281700018 ER PT J AU Stoltz, AJ Benson, JD Boyd, PR Martinka, M Varesi, JB Kaleczyc, AW Smith, EPG Johnson, SM Radford, WA Dinan, JH AF Stoltz, AJ Benson, JD Boyd, PR Martinka, M Varesi, JB Kaleczyc, AW Smith, EPG Johnson, SM Radford, WA Dinan, JH TI The effect of electron cyclotron resonance plasma parameters on the aspect ratio of trenches in HgCdTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT Workshop on Physics and Chemistry of II-VI Materials CY NOV 13-15, 2002 CL SAN DIEGO, CALIFORNIA SP USA, CECOM Night Vis & Elect Sensors Directorate, USA, Res Lab, USA, SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Miner, Mat & Mat Soc DE electron cyclotron resonance (ECR); reactive ion etching (RIE); plasma; focal plane array (FPA); HgCdTe (mercury cadmium telluride); etch lag; aspect ratio ID PHOTORESIST-FEATURE GEOMETRY; II-VI SEMICONDUCTORS; ION ETCH LAG; FEATURES; GROWTH; BOMBARDMENT; DETECTORS; REDUCTION; SILICON; CDZNTE AB Values of the aspect ratio for trenches etched into HgCdTe by an electron cyclotron resonance (ECR) plasma containing hydrogen and argon are limited by the phenomenon of etch lag. Modeling this plasma as an ion assisted, reactive-etching process leads to a set of conditions that greatly reduces etch lag. Use of these new process conditions produces trenches with aspect ratios greater than 3, widths less than 3 mum, and depths in excess of 15 mum. C1 USA, CECOM, RDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. Raytheon Infrared Operat, Goleta, CA 93117 USA. USA, Res Lab, Adelphi, MD 20873 USA. RP Stoltz, AJ (reprint author), USA, CECOM, RDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. NR 36 TC 25 Z9 25 U1 0 U2 0 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2003 VL 32 IS 7 BP 692 EP 697 DI 10.1007/s11664-003-0054-x PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 703LW UT WOS:000184281700019 ER PT J AU Brill, G Chen, Y Dhar, NK Singh, R AF Brill, G Chen, Y Dhar, NK Singh, R TI Nucleation of ZnTe/CdTe epitaxy on high-Miller-index Si surfaces SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT Workshop on Physics and Chemistry of II-VI Materials CY NOV 13-15, 2002 CL SAN DIEGO, CALIFORNIA SP USA, CECOM Night Vis & Elect Sensors Directorate, USA, Res Lab, USA, SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Miner, Mat & Mat Soc DE nucleation; Si; x-ray photoelectron spectroscopy (XPS); CdTe; adsorption; molecular-beam epitaxy (MBE) ID GROWTH; HETEROEPITAXY; HGCDTE; CDZNTE; CDTE AB Tellurium-adsorption studies were conducted on {111}-type Si surfaces that are off-cut from the {111} in the range of 0-30degrees on both nonpassivated- and arsenic-passivated Si surfaces. Relative surface coverages as a function of Te exposure time and Si-surface orientation were obtained with in-situ x-ray photoelectron spectroscopy (XPS). The XPS results indicate that Te coverage on arsenic-passivated Si surfaces increases as the step density of the surface increases. In contrast, Te-adsorption studies conducted on nonpassivated-Si surfaces showed no dependence between TO coverage and the surface-step density. Subsequent ZnTe and CdTe molecular-beam epitaxial growth on these high-Miller-index Si surfaces further validate a step-edge nucleation model. Additionally, it was observed that the CdTe-epilayer orientation did not always reproduce the Si-substrate orientation and was a function of both the initial Si surface and the growth conditions used. C1 USA, Res Lab, Adelphi, MD 20783 USA. EPIR Ltd, Bolingbrook, IL 60440 USA. RP Brill, G (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. RI Brill, Gregory/G-4877-2013 NR 10 TC 21 Z9 21 U1 2 U2 8 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2003 VL 32 IS 7 BP 717 EP 722 DI 10.1007/s11664-003-0058-6 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 703LW UT WOS:000184281700023 ER PT J AU Chen, YP Brill, G Dhar, NK AF Chen, YP Brill, G Dhar, NK TI Molecular-beam epitaxial growth of CdSexTe1-x on Si(211) SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT Workshop on Physics and Chemistry of II-VI Materials CY NOV 13-15, 2002 CL SAN DIEGO, CALIFORNIA SP USA, CECOM Night Vis & Elect Sensors Directorate, USA, Res Lab, USA, SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Miner, Mat & Mat Soc DE CdSeTe; molecular-beam epitaxy (MBE); CdTe; Si; HgCdTe; long-wavelength infrared (LWIR) ID FOCAL-PLANE ARRAYS; MBE GROWTH; CDTE; HGCDTE; DETECTORS; CDZNTE; ZNTE AB We report on the first successful growth of the ternary-alloy CdSexTe1-x(211) on 3-in. Si(211) substrates using molecular-beam epitaxy (MBE). The growth of CdSeTe was performed using a compound CdTe effusion source and an elemental Se effusion source. The alloy composition (x) of the CdSexTe1-x ternary compound was controlled through the Se:CdTe flux ratios. Our results indicated that the crystalline quality of CdSeTe decreases as the alloy composition increases, which is possibly due to an alloy-disordering effect. A similar trend was observed for the CdZnTe ternary-alloy system. However, the alloy-disordering effect in CdSeTe was found to be less severe than that in CdZnTe. We have carried out the growth of CdSeTe on Si at different temperatures. An optimized growth window was established for CdSeTe on Si(211) to achieve high-crystalline-quality CdSeTe/Si layers with 4% Se. The as-grown layers exhibited excellent surface morphology, low surface-defect density (less than 500 cm(-2)), and low x-ray full width at half maximum (FWHM) values near 100 arcsec. Additionally, the CdSeTe/Si layer exhibited excellent lateral uniformity and the best etched-pit density (EPD) value on a 4% CdSeTe, measured to be as low as 1.4 x 10(5) cm(-2). C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, YP (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. RI Brill, Gregory/G-4877-2013 NR 14 TC 12 Z9 13 U1 0 U2 4 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2003 VL 32 IS 7 BP 723 EP 727 DI 10.1007/s11664-003-0059-5 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 703LW UT WOS:000184281700024 ER PT J AU Chu, MR Terterian, S Ting, D Wang, CC Benson, JD Dinan, JH James, RB Burger, A AF Chu, MR Terterian, S Ting, D Wang, CC Benson, JD Dinan, JH James, RB Burger, A TI Effects of excess tellurium on the properties of CdZnTe radiation detectors SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT Workshop on Physics and Chemistry of II-VI Materials CY NOV 13-15, 2002 CL SAN DIEGO, CALIFORNIA SP USA, CECOM Night Vis & Elect Sensors Directorate, USA, Res Lab, USA, SMDC, USN, Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Miner, Mat & Mat Soc DE CdZnTe; radiation detector; gamma-ray detector; defect; tellurium antisite; deep level; cadmium vacancy; inhomogeneity; HgCdTe ID COMPENSATION; CDTE; MODEL AB Room-temperature radiation detectors have been fabricated on high-resistivity, indium-doped Cd0.90Zn0.10Te crystals grown under different amounts of excess Te. The effects of the excess Te on the properties of the detectors are explained by a simple model using only three parameters: the density of Cd vacancies, the density of Te antisites (Te at Cd sites), and the deep level of doubly ionized Te antisites. The best detectors, which can resolve the low-energy Np-L and Te-K peaks as well as Cd and Te escape peaks of Am-241, are produced from crystals grown with 1.5% excess Te. The detectors fabricated from crystals grown without excess Te are unable to resolve any characteristic-radiation peaks of Am-241 and Co-57. This result is explained by a model of networked p-type domains in an n-type matrix or vice versa, which is caused by the lack of sufficient deep-level Te antisites. Such conduction-type inhomogeneity causes massive electron and hole trapping. As for the detectors fabricated from Cd0.90Zn0.10Te crystals grown with 2% and 3% excess Te, they are able to resolve the Am-241 59.5-keV, Co-57 122-keV, and Co-57 136-keV radiation peaks. However, the full-width at half-maximum (FWHM) values of these peaks are broadened, especially the high-energy Co-57 peaks. These phenomena are attributed to the hole and, possibly, electron trapping by Cd vacancies and Te antisites, respectively. The result of the analysis indicates that sufficient Te antisites and a low density of carrier traps in Cd0.90Zn0.10Te are essential for producing high-quality radiation detectors. In the analysis, it was discovered that most of the excess Te, on the order of 1-2 x 10(20) cm(-3), remain electrically inactive. A possible explanation for this phenomenon is that the excess Te atoms form neutral Te-antisite and Cd-vacancy complexes, such as Te-Cd.(V-Cd)(2), during the post-growth cooling process. C1 Fermion Corp, Simi Valley, CA 93063 USA. USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. Fisk Univ, Nashville, TN 37208 USA. Brookhaven Natl Lab, Upton, NY 11973 USA. RP Chu, MR (reprint author), Fermion Corp, Simi Valley, CA 93063 USA. NR 12 TC 16 Z9 19 U1 0 U2 5 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2003 VL 32 IS 7 BP 778 EP 782 DI 10.1007/s11664-003-0070-x PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 703LW UT WOS:000184281700035 ER PT J AU Miller, JD Danzer, SR Watts, JM Stone, S Yool, SR AF Miller, JD Danzer, SR Watts, JM Stone, S Yool, SR TI Cluster analysis of structural stage classes to map wildland fuels in a Madrean ecosystem SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE wildland fuels; structural stage; hierarchal cluster analysis; remote sensing; Madrean vegetation; Southwestern US ID GRADIENT ANALYSIS; FIRE; CLASSIFICATION; VEGETATION; UNDERSTORY; ACCURACY; SIZE AB Geospatial information technology is changing the nature of fire mapping science and management. Geographic information systems (GIS) and global positioning system technology coupled with remotely sensed data provide powerful tools for mapping, assessing, and understanding the complex spatial phenomena of wildland fuels and fire hazard. The effectiveness of these technologies for fire management still depends on good baseline fuels data since techniques have yet to be developed to directly interrogate understory fuels with remotely sensed data. We couple field data collections with GIS, remote sensing, and hierarchical clustering to characterize and map the variability of wildland fuels within and across vegetation types. One hundred fifty six fuel plots were sampled in eight vegetation types ranging in elevation from 1150 to 2600 m surrounding a Madrean 'sky island' mountain range in the southwestern US. Fuel plots within individual vegetation types were divided into classes representing various stages of structural development with unique fuel load characteristics using a hierarchical clustering method. Two Landsat satellite images were then classified into vegetation/fuel classes using a hybrid unsupervised/supervised approach. A back-classification accuracy assessment, which uses the same pixels to test as used to train the classifier, produced an overall Kappa of 50% for the vegetation/fuels map. The map with fuel classes within vegetation type collapsed into single classes was verified with an independent dataset, yielding an overall Kappa of 80%. (C) 2003 Elsevier Science Ltd. All fights reserved. C1 Univ Arizona, Dept Geog & Reg Dev, Tucson, AZ 85721 USA. USA, Mil Garrison, Ft Huachuca, AZ 85613 USA. USA, Ctr Res Dev & Engn, Topog Engn Ctr, Alexandria, VA 22315 USA. RP Miller, JD (reprint author), Univ Arizona, Dept Geog & Reg Dev, Harvill Bldg,Box 2, Tucson, AZ 85721 USA. EM jdmiller@email.arizona.edu; shelley.danzer@hua.army.mil; watts@tec.army.mil; sheridan.stone@hua.arrny.mil; yool@skydog.geog.arizona.edu NR 54 TC 15 Z9 18 U1 0 U2 3 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD JUL PY 2003 VL 68 IS 3 BP 239 EP 252 DI 10.1016/S0301-4797(03)00062-8 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA 702RF UT WOS:000184236500003 PM 12837253 ER PT J AU Ringelberg, DB Reynolds, CM Walsh, ME Jenkins, TF AF Ringelberg, DB Reynolds, CM Walsh, ME Jenkins, TF TI RDX loss in a surface soil under saturated and well drained conditions SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID DEGRADATION; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; EXPLOSIVES; BIOTRANSFORMATION; MINERALIZATION; SLURRY AB On military training ranges, low-order, incomplete detonations deposit RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) into surface soils. In this study, we evaluated RDX biodegradation in surface soils obtained from a military training range in Alaska. Two factors were compared: (i) soil water potential during the incubations; and (ii) the use of acetonitrile (ACN) as an RDX carrier to spike samples. Organic solvents have been used in laboratory studies to dissolve slightly watersoluble contaminants before addition to soil. We added ACN to obtain final soil ACN concentrations of 0 mg kg(-1) (0%), 1000 mg kg(-1) (0.1%) and 10 000 mg kg(-1) (1%). We then compared RDX attenuation in the soil under saturated and unsaturated conditions. RDX fell below the limit of detection within 3 wk of study initiation under the saturated condition. A maximum degradation rate of 0.15 mg RDX L-1 d(-1) was measured. Under the unsaturated condition, 42% of the original RDX was still present at study termination (5 wk). The addition of acetonitrile at 0.1 or 1.0% had no affect on RDX loss in the saturated soil. In the unsaturated soil, however, ACN at 1.0% inhibited RDX loss by as much as 25%. These findings indicate that soil water potential and carrier solvent concentrations can impact the rate and extent to which RDX is attenuated in a surface soil. C1 USA, Erdc, CRREL, Hanover, NH 03755 USA. RP Ringelberg, DB (reprint author), USA, Erdc, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. NR 30 TC 17 Z9 17 U1 1 U2 7 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD JUL-AUG PY 2003 VL 32 IS 4 BP 1244 EP 1249 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 700EN UT WOS:000184099800009 PM 12931878 ER PT J AU Dubey, JP Shkap, V Pipano, E Fish, L Fritz, DL AF Dubey, JP Shkap, V Pipano, E Fish, L Fritz, DL TI Ultrastructure of Besnoitia besnoiti tissue cysts and bradyzoites SO JOURNAL OF EUKARYOTIC MICROBIOLOGY LA English DT Article DE cattle; enigmatic bodies; ultrastructure ID CYCLIC TRANSMISSION; ELECTRON-MICROSCOPY; CATS; JELLISONI; DARLINGI; TOXOPLASMATINAE; PROTOZOA; OPOSSUMS; COCCIDIA; GOATS AB Besnoitia besnoiti is an economically important tissue cyst-forming apicomplexan of cattle in Africa and Israel. Tissue cysts and bradyzoites of B. besnoiti from the skin of a naturally infected bull were studied by transmission electron microscopy. Tissue cysts enclosed host cell and bradyzoites. Bradyzoites were 6-7.5x1.9-2.3 mum in size and contained organelles found in coccidian merozoites including numerous micronemes, rhoptries, amylopectin granules, and a posteriorly located nucleus. Enigmatic bodies, characteristically found in Besnoitia sp. bradyzoites, were not observed. Therefore, enigmatic bodies should be removed as a generic character of the bradyzoites of Besnoitia species. C1 USDA ARS, Anim & Nat Resources Inst, Anim Parasit Dis Epidemiol & Systemat Lab, Beltsville, MD 20705 USA. Kimron Vet Inst, Div Parasitol, IL-50250 Bet Dagan, Israel. USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Dubey, JP (reprint author), USDA ARS, Anim & Nat Resources Inst, Anim Parasit Dis Epidemiol & Systemat Lab, Beltsville, MD 20705 USA. NR 24 TC 26 Z9 30 U1 2 U2 3 PU SOC PROTOZOOLOGISTS PI LAWRENCE PA 810 E 10TH ST, LAWRENCE, KS 66044 USA SN 1066-5234 J9 J EUKARYOT MICROBIOL JI J. Eukaryot. Microbiol. PD JUL-AUG PY 2003 VL 50 IS 4 BP 240 EP 244 DI 10.1111/j.1550-7408.2003.tb00127.x PG 5 WC Microbiology SC Microbiology GA 712BW UT WOS:000184777300002 PM 15132166 ER PT J AU Byrd, JE Adams, BJ AF Byrd, JE Adams, BJ TI Osteometric sorting of commingled human remains SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; forensic anthropology; commingling; human osteology; osteometric sorting; regression analysis; CILHI ID ANTHROPOLOGY; ALLOMETRY; SIZE AB This paper describes the method of osteometric sorting. Osteometric sorting is the formal use of size and shape to sort bones from one another. The method relies heavily on measurement data and statistical models and is designed to maximize objectivity. The goal of this paper is to validate the use of osteometric sorting and to provide case examples of its utility. Selected regression models are also presented for use with osteometric sorting. We advocate this technique as one tool among many in the anthropologist's toolkit for sorting commingled skeletal remains. C1 USA, CILHI, Cent Identificat Lab, Hickam AFB, HI 96853 USA. RP Byrd, JE (reprint author), USA, CILHI, Cent Identificat Lab, 310 Worchester Ave, Hickam AFB, HI 96853 USA. NR 21 TC 19 Z9 19 U1 3 U2 16 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JUL PY 2003 VL 48 IS 4 BP 717 EP 724 PG 8 WC Medicine, Legal SC Legal Medicine GA 697HC UT WOS:000183935600004 PM 12877285 ER PT J AU Okasaki, C AF Okasaki, C TI Flattening combinators: surviving without parentheses SO JOURNAL OF FUNCTIONAL PROGRAMMING LA English DT Editorial Material AB A combinator expression is flat if it can be written without parentheses, that is, if all applications nest to the left, never to the right. This note explores a simple method for flattening combinator expressions involving arbitrary combinators. C1 US Mil Acad, W Point, NY 10996 USA. RP Okasaki, C (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 3 TC 1 Z9 1 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH ST, NEW YORK, NY 10011-4221 USA SN 0956-7968 J9 J FUNCT PROGRAM JI J. Funct. Program PD JUL PY 2003 VL 13 BP 815 EP 822 DI 10.1017/S0956796802004483 PN 4 PG 8 WC Computer Science, Software Engineering SC Computer Science GA 709QN UT WOS:000184636000004 ER PT J AU Wilkinson, NW Euhus, DM AF Wilkinson, NW Euhus, DM TI Adenoviral-mediated gene transfer of interleukin-2 in a human breast cancer cell line and a fresh primary breast cancer culture SO JOURNAL OF INVESTIGATIVE SURGERY LA English DT Article DE adenovirus; breast cancer; cytokine; gene therapy; gene transfer; interleukin-2 ID TUMOR-REGRESSION; VECTORS; MURINE; IMMUNITY; MODEL; TRANSDUCTION; INDUCTION; IL-2 AB Adenovirally-mediated cytokine gene transfer has proven safe in the treatment of metastatic breast cancer. Unfortunately, the optimal conditions for gene transfer in the human breast remain largely unknown. Viral-mediated gene transfer was studied in a human breast cancer cell line and a fresh primary breast cancer culture using a type five adenoviral vector (AD5) containing the human interleukin 2 (IL-2) gene driven by a cytomegalovirus (CMV) promoter (AD5.CMV-IL2). IL-2 production was measured using an enzyme-linked immunosorbent assay (ELISA). In the human breast cancer cell line (MCF-7), IL-2 production increased logarithmically with viral dose and demonstrated peak production at 2000 ng/10 6 cells/24 h using a multiplicity of infection (MOI) of 3000:1. Transduction at a higher MOI resulted in cell death. IL-2 concentration reached over 2000 ng/ml 2 days after transduction and peaked 13 days after transduction at 5700 ng/ml. IL-2 levels declined thereafter. A fresh primary breast cancer culture, transduced with Ad5.CMV-IL2 at an MOI of 1000:1, secreted IL-2 at 15 ng/24 h 1 day after transduction and peaked at 85 ng/24 h 5 days after transduction. Adenoviral-mediated gene transfer was accomplished in breast cancer cells with high efficiency across a wide range of conditions. The optimal IL-2 dose required to maximally stimulate the immune system remains unknown. C1 Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Wilkinson, NW (reprint author), Roswell Pk Canc Inst, Elm & Carlton St, Buffalo, NY 14263 USA. NR 16 TC 2 Z9 2 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0894-1939 J9 J INVEST SURG JI J. Invest. Surg. PD JUL-AUG PY 2003 VL 16 IS 4 BP 203 EP 208 DI 10.1080/08941930390214845 PG 6 WC Surgery SC Surgery GA 707BU UT WOS:000184490200004 PM 12893496 ER PT J AU Lee, YS Wetzel, ED Wagner, NJ AF Lee, YS Wetzel, ED Wagner, NJ TI The ballistic impact characteristics of Kevlar (R) woven fabrics impregnated with a colloidal shear thickening fluid SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID CONCENTRATED SUSPENSIONS; PARTICLE-SIZE; DISPERSIONS; RHEOLOGY; FLOW; BEHAVIOR AB This study reports the ballistic penetration performance of a composite material composed of woven Kevlar(R) fabric impregnated with a colloidal shear thickening fluid (silica particles (450 nm) dispersed in ethylene glycol). The impregnated Kevlar fabric yields a flexible, yet penetration resistant composite material. Fragment simulation projectile (FSP) ballistic penetration measurements at similar to244 m/s have been performed to demonstrate the efficacy of the novel composite material. The results demonstrate a significant enhancement in ballistic penetration resistance due to the addition of shear thickening fluid to the fabric, without any loss in material flexibility. Furthermore, under these ballistic test conditions, the impregnated fabric targets perform equivalently to neat fabric targets of equal areal density, while offering significantly less thickness and more material flexibility. The enhancement in ballistic performance is shown to be associated with the shear thickening response, and possible mechanisms of fabric-fluid interaction during ballistic impact are identified. (C) 2003 Kluwer Academic Publishers. C1 Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wagner, NJ (reprint author), Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. RI Wagner, Norman/B-6558-2012 OI Wagner, Norman/0000-0001-9565-619X NR 27 TC 285 Z9 311 U1 16 U2 201 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUL 1 PY 2003 VL 38 IS 13 BP 2825 EP 2833 DI 10.1023/A:1024424200221 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA 695MU UT WOS:000183835300006 ER PT J AU Sithiprasasna, R Mahapibul, P Noigamol, C Perich, MJ Zeichner, BC Burge, B Norris, SLW Jones, JW Schleich, SS Coleman, RE AF Sithiprasasna, R Mahapibul, P Noigamol, C Perich, MJ Zeichner, BC Burge, B Norris, SLW Jones, JW Schleich, SS Coleman, RE TI Field evaluation of a lethal ovitrap for the control of Aedes aegypti (Diptera : Culicidae) in Thailand SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes mosquitoes; surveillance; control; dengue; lethal ovitrap ID SURVEILLANCE; ALBOPICTUS; EFFICACY; VECTOR; CITY AB In 1999 and 2000 we evaluated a lethal ovitrap (LO) for the control of Aedes aegypti (L.) in three villages in Ratchaburi Province, Thailand. Two blocks of 50 houses (a minimum of 250 in apart) served as treatment and control sites in each village, with each house in the treatment area receiving 10 LOs. Thirty houses in the center of each treatment and control block were selected as sampling sites, with larval and adult mosquito sampling initiated when LOS were placed. Sampling was conducted weekly in 10 of the 30 houses at each site, with each block of 10 houses sampled every third week. Sampling continued for 30 wk. Efficacy of the LO was evaluated by determining number of containers with larvae and/ or pupae per house and number of adult mosquitoes collected inside each house. In 1999, the LO bad a negligible impact on all measures of Ae. aegypti abundance that were assessed; however, fungal contamination of insecticide-impregnated strips may have been responsible for the low efficacy. In 2000, significant suppression was achieved based on changes in multiple entomologic criteria (containers with larvae, containers with pupae, and number of adult Ae. aegypti); however, control was not absolute and neither immature nor adult Ae. aegypti were ever eliminated completely. We conclude that the LO can reduce adult Ae. aegypti populations in Thailand; however, efficacy of the LO is lower than desired due primarily to the high number of alternative oviposition sites. LO efficacy may be improved when Used as part of an integrated control program that places emphasis on reduction of adjacent larval habitats. Further studies are required to assess this issue. C1 Armed Forces Res Inst Med Sci, USA Med Component, Dept Entomol, Bangkok 10400, Thailand. RP Noigamol, C (reprint author), Armed Forces Res Inst Med Sci, USA Med Component, Dept Entomol, Bangkok 10400, Thailand. NR 34 TC 33 Z9 35 U1 0 U2 6 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2003 VL 40 IS 4 BP 455 EP 462 DI 10.1603/0022-2585-40.4.455 PG 8 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 705TJ UT WOS:000184410900013 PM 14680111 ER PT J AU Turell, MJ O'Guinn, ML Wasieloski, LP Dohm, DJ Lee, WJ Cho, HW Kim, HC Burkett, DA Mores, CN Coleman, RE Klein, TA AF Turell, MJ O'Guinn, ML Wasieloski, LP Dohm, DJ Lee, WJ Cho, HW Kim, HC Burkett, DA Mores, CN Coleman, RE Klein, TA TI Isolation of Japanese encephalitis and Getah viruses from mosquitoes (Diptera : Culicidae) collected near Camp Greaves, Gyonggi Province, Republic of Korea, 2000 SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE virus; isolation; mosquitoes; Korea; Japanese encephalitis; Getah ID POLYMERASE CHAIN-REACTION; CULEX-TRITAENIORHYNCHUS; SAGIYAMA VIRUS; ALPHAVIRUSES; INFECTION; THAILAND AB As part of an evaluation of the ecology of arthropod-borne diseases in the Republic of Korea (ROK), we examined 8,765 mosquitoes captured in Paju County, Gyonggi Province, ROK, for the presence of viruses. Mosquitoes were captured in propane lantern/human-baited Shannon traps, Mosquito Magnet traps, or American Biophysics Corporation (East Greenwich, RI) miniature light traps with or without supplemental octenol bait and/ or dry ice. Mosquitoes were identified to species, placed in pools of up to 40 mosquitoes each, and tested on Vero cells for the presence of virus. A total of 15 virus isolations were made from 293 pools of mosquitoes. Viruses were identified by reverse transcriptase-polymerase chain reaction and sequencing and consisted of 14 isolations of Japanese encephalitis (JE) virus and one isolation of Getah (GET) virus. All JE isolates were from Culex tritaeniorhynchus Giles, and the isolate of GET was from Aedes vexans (Meigen). The minimum field infection rate for JE in Cx. tritaeniorhynchus was 3.3 per 1,000, whereas the GET virus infection rate for Ae. vexans was 0.2 per 1,000. Isolation of JE and GET indicated that both viruses were actively circulating in northern Gyonggi Province, ROK. The lack of human cases of JE among the Korean population probably is because of an effective government-mandated vaccination program. The reason for no cases among >10,000 United States military and others that reside or train nearby is unknown, but may be related to personnel protection measures (permethrin-impregnated uniforms and use of deet repellent), adult mosquito control, mosquito selection of nonhuman hosts (unpublished data), and the low symptomatic to asymptomatic ratio of disease in adults. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. Natl Inst Hlth, Dept Viral Dis, Seoul 122701, South Korea. 5th Med Detachment, Med Battalion 168, Med Command 18, Unit 15247, APO, AP 96205 USA. USAF, Detachment 3, Inst Environm Safety & Occupat Hlth Risk Anal, APO, AP 96368 USA. Prevent Serv Directorate, Med Command 18, Unit 15281, APO, AP 96205 USA. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.turell@det.amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 25 TC 22 Z9 29 U1 2 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2003 VL 40 IS 4 BP 580 EP 584 DI 10.1603/0022-2585-40.4.580 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 705TJ UT WOS:000184410900032 PM 14680130 ER PT J AU Sieg, KG AF Sieg, KG TI How wars are won: The 13 rules of war from ancient Greece to the war on terror. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, Corps Engn, Alexandria, VA USA. RP Sieg, KG (reprint author), USA, Corps Engn, Alexandria, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2003 VL 67 IS 3 BP 924 EP 925 DI 10.1353/jmh.2003.0258 PG 2 WC History SC History GA 697CU UT WOS:000183925300010 ER PT J AU Rogers, CJ AF Rogers, CJ TI The battle of Poitiers, 1356. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Rogers, CJ (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2003 VL 67 IS 3 BP 933 EP 934 DI 10.1353/jmh.2003.0248 PG 2 WC History SC History GA 697CU UT WOS:000183925300017 ER PT J AU Kiesling, EC AF Kiesling, EC TI 14-18: Understanding the Great War. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Kiesling, EC (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2003 VL 67 IS 3 BP 961 EP 963 DI 10.1353/jmh.2003.0232 PG 3 WC History SC History GA 697CU UT WOS:000183925300040 ER PT J AU Giangreco, DM AF Giangreco, DM TI Untitled SO JOURNAL OF MILITARY HISTORY LA English DT Letter C1 USA, Command & Gen Coll, Leavenworth, KS USA. RP Giangreco, DM (reprint author), USA, Command & Gen Coll, Leavenworth, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2003 VL 67 IS 3 BP 1037 EP 1038 DI 10.1353/jmh.2003.0220 PG 2 WC History SC History GA 697CU UT WOS:000183925300074 ER PT J AU Francis, PO McPherson, JC Cuenin, MF Hokett, SD Peacock, ME Billman, MA Sharawy, M AF Francis, PO McPherson, JC Cuenin, MF Hokett, SD Peacock, ME Billman, MA Sharawy, M TI Evaluation of a novel alloplast for osseous regeneration in the rat calvarial model SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE Animal studies; bone regeneration; foreign bodies; growth factors, transforming; models, animal; wound healing ID BONE REGENERATION; DEFECTS AB Background: Alloplasts are inert foreign bodies acting as osteoconductive space maintainers during osseous wound healing. They may also function as carriers for growth factors that are known to enhance neovascularization and osteoinduction; human recombinant transforming growth factor beta (rhTGF-beta1) is one such factor. The purpose of this study was to evaluate di-vinyl styrene beads (DVSb) and rhTGF-beta1 effects on osseous regeneration in the rat calvaria critical-sized defect model. Methods: Di-vinyl styrene beads (DVSb) with and without rhTGF-beta1 were placed between gelfilm membranes in a critical-sized defect in the rat (Rattus norvegicus) calvaria. Actual bone fill; percentage bone fill; bone formation rate (BFR); and mineralization at 3, 6, and 12 weeks postsurgery were measured using densitometry, histomorphometry, scanning electron microscopy (SEM), and vital staining with tetracycline - HCL Results: Mean radiographic density and percentage fill were statistically greater for DVSb treatment groups as compared with controls (P less than or equal to 0.05). BFR was consistently between 3 and 7 pm per day for all groups; alloplast group BFR was significantly greater than controls or the rhTGF-beta1 groups at 6 weeks (P : 0.05); however, at 3 and 12 weeks, the control BFR was greater than treatment groups (P :! 0.05). Membranes often collapsed and little bone fill or mineralization occurred in defects without DVSb. Mineralization appeared to occur adjacent to the alloplast by 12 weeks in the histologic and SEM sections. While DVSb fibrous attachment occurred in some specimens, there was no evidence of an inflammatory response. Conclusion: Di-vinyl styrene beads, with or without rhTGF-beta1, significantly enhance bone regeneration in the rat calvaria defect model. C1 USA, Dent Activ, Ft Lewis, WA USA. DD Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. USA, Periodont Residency, Ft Gordon, GA USA. Med Coll Georgia, Dept Periodont, Augusta, GA 30912 USA. Med Coll Georgia, Dept Oral Biol, Augusta, GA 30912 USA. RP Francis, PO (reprint author), USA, Dent Activ, Tingay Dent Clin, Bldg 320,E Hosp Rd, Ft Gordon, GA 30905 USA. NR 23 TC 4 Z9 4 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 USA SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD JUL PY 2003 VL 74 IS 7 BP 1023 EP 1031 DI 10.1902/jop.2003.74.7.1023 PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 754KJ UT WOS:000187315200011 PM 12931765 ER PT J AU Young, SK Trevino, SF Tan, NCB Paul, RL AF Young, SK Trevino, SF Tan, NCB Paul, RL TI Utilization of prompt-gamma neutron activation analysis in the evaluation of Nafion membranes SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE Nafion; perfluorosulfonate ionomer membranes; prompt-gamma neutron activation analysis; ion exchangers; counterion form membranes; ionomers; membranes ID ANGLE X-RAY; PERFLUORINATED IONOMER MEMBRANES; WATER; SCATTERING; BEHAVIOR; POLYMER AB Researchers have performed evaluations on Nafion membranes for many years. An important aspect of the membranes is their chemical composition and uniformity. One technique that could provide accurate and fast quantitative measurements of the chemical composition and water within the membranes is prompt-gamma neutron activation analysis (PGAA). In this work, PGAA was applied to the chemical characterization of Nafion membranes in various forms. The evaluation confirmed the necessity of pretreatment of the membranes for the elimination of contamination. A series of counterion-exchanged membranes were examined so that we could determine the degree of conversion achieved under different conditions and residual water levels. The results indicated that the type of counterion was an important factor determining conversion levels, that partial conversion could be achieved, and that counterion displacement could be forced to occur in certain environments. (C) 2003 Wiley Periodicals, Inc. C1 USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. RP Young, SK (reprint author), USA, Ballist Res Lab, WMSRL WM MA Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. NR 20 TC 7 Z9 7 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD JUL 1 PY 2003 VL 41 IS 13 BP 1485 EP 1492 DI 10.1002/polb.10488 PG 8 WC Polymer Science SC Polymer Science GA 690RZ UT WOS:000183564000006 ER PT J AU Salkind, AJ Singh, P Cannone, A Atwater, T Wang, XQ Reisner, D AF Salkind, AJ Singh, P Cannone, A Atwater, T Wang, XQ Reisner, D TI Impedance modeling of intermediate size lead-acid batteries SO JOURNAL OF POWER SOURCES LA English DT Article; Proceedings Paper CT 8th European Lead Battery Conference CY SEP 10-13, 2002 CL ROME, ITALY SP Lead Dev Assoc Int DE lead-acid batteries; electrochemical impedance spectroscopy; VRLA batteries; modeling of battery equivalent circuits ID STATE-OF-CHARGE; HEALTH AB This presentation continues the study of the dynamic characteristics of lead-acid batteries previously reported into larger cells and batteries. Electrochemical impedance spectroscopy combined with fuzzy logic methodology of data analysis was used to characterize 6 V 10 Ah VRLA batteries and larger batteries used in tanks and other vehicles. Equivalent circuits were derived which can be used to estimate state-of-charge (SOC) and state-of-health. (C) 2003 Elsevier Science B.V. All rights reserved. C1 Rutgers State Univ, Ctr Battery Mat & Engn, Sch Engn, Piscataway, NJ 08854 USA. Villanova Univ, Villanova, PA 19085 USA. USA, CECOM, RD&EC, Ft Monmouth, NJ 07703 USA. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA. US Nanocorp Inc, Farmington, CT 06032 USA. RP Salkind, AJ (reprint author), Rutgers State Univ, Ctr Battery Mat & Engn, Sch Engn, 98 Brett Rd, Piscataway, NJ 08854 USA. NR 11 TC 21 Z9 22 U1 2 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JUL 1 PY 2003 VL 116 IS 1-2 BP 174 EP 184 DI 10.1016/S0378-7753(02)00690-0 PG 11 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 697BM UT WOS:000183922400024 ER PT J AU Winn, J AF Winn, J TI Avoiding death by PowerPoint SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article C1 US Mil Acad, Dept Law, W Point, NY 10996 USA. NR 8 TC 5 Z9 5 U1 2 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD JUL PY 2003 VL 129 IS 3 BP 115 EP 118 DI 10.1061/(ASCE)1052-3928(2003)129:3(115) PG 4 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA 693MB UT WOS:000183720400001 ER PT J AU Adler, M Shafer, HF Manley, HA Hackley, BE Nicholson, JD Keller, JE Goodnough, MC AF Adler, M Shafer, HF Manley, HA Hackley, BE Nicholson, JD Keller, JE Goodnough, MC TI A capillary electrophoresis technique for evaluating botulinum neurotoxin B light chain activity SO JOURNAL OF PROTEIN CHEMISTRY LA English DT Article DE botulinum neurotoxin B; Clostridium botulinum; capillary electrophoresis; VAMP/synaptobrevin; enzymatic cleavage ID CLOSTRIDIAL NEUROTOXINS; TETANUS; SYNAPTOBREVIN; CLEAVAGE; PROTEASE; RELEASE AB Botulinum neurotoxin B (BoNT/B) produces muscle paralysis by cleaving synaptobrevin/vesicle-associated membrane protein (VAMP), an 18-kDa membrane-associated protein located on the surface of small synaptic vesicles. A capillary electrophoresis (CE) assay was developed to evaluate inhibitors of the proteolytic activity of BoNT/B with the objective of identifying suitable candidates for treatment of botulism. The assay was based on monitoring the cleavage of a peptide that corresponds to residues 44 - 94 of human VAMP-2 (V51) following reaction with the catalytic light chain (LC) of BoNT/B. Cleavage of V51 generated peptide fragments of 18 and 33 amino acids by scission of the bond between Q76 and F77. The fragments and parent peptide were clearly resolved by CE, allowing accurate quanti. cation of the BoNT/B LC-mediated reaction rates. The results indicate that CE is suitable for assessing the enzymatic activity of BoNT/B LC. C1 USA, Neurotoxicol Branch, Div Pharmacol, Med Res Inst Chem Def,MCMR UV PN, Aberdeen Proving Ground, MD 21010 USA. USA, Off Commander, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. US FDA, Lab Bacterial Toxins, CEBER, Rockville, MD 20852 USA. Univ Wisconsin, Food Res Inst, Dept Food Microbiol, Madison, WI 53706 USA. RP Adler, M (reprint author), USA, Neurotoxicol Branch, Div Pharmacol, Med Res Inst Chem Def,MCMR UV PN, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM Michael.Adler@amedd.army.mil NR 22 TC 10 Z9 10 U1 0 U2 0 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0277-8033 J9 J PROTEIN CHEM JI J. Protein Chem. PD JUL PY 2003 VL 22 IS 5 BP 441 EP 448 DI 10.1023/B:JOPC.0000005459.00492.60 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 748MM UT WOS:000186865700006 PM 14690246 ER PT J AU VanLandingham, MR AF VanLandingham, MR TI Review of instrumented indentation SO JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY LA English DT Review DE calibration methods; contact mechanics; depth-sensing indentation; elastic modulus; instrumented indentation; measurement science; nanoindentation; tip shape characterization ID DEPTH-SENSING INDENTATION; FILM MECHANICAL-PROPERTIES; PYRAMIDAL INDENTATION; FORCE MICROSCOPY; SINGLE-CRYSTALS; TIP GEOMETRY; NANOINDENTATION; LOAD; INDENTER; HARDNESS AB Instrumented indentation, also known as depth-sensing indentation or nanoindentation, is increasingly being used to probe the mechanical response of materials from metals and ceramics to polymeric and biological materials. The additional levels of control, sensitivity, and data acquisition offered by instrumented indentation systems have resulted in numerous advances in materials science, particularly regarding fundamental mechanisms of mechanical behavior at micrometer and even sub-micrometer length scales. Continued improvements of instrumented indentation testing towards absolute quantification of a wide range of material properties and behavior will require advances in instrument calibration, measurement protocols, and analysis tools and techniques. In this paper, an overview of instrumented indentation is given with regard to current instrument technology and analysis methods. Research efforts at the National Institute of Standards and Technology (NIST) aimed at improving the related measurement science are discussed. C1 Natl Inst Stand & Technol, Mat & Construct Res Div, Bldg & Fire Res Lab, Gaithersburg, MD 20899 USA. RP VanLandingham, MR (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Polymers Res Branch, Aberdeen Proving Ground, MD 21005 USA. EM mark.vanlandingham@us.army.mil NR 61 TC 211 Z9 217 U1 9 U2 84 PU US GOVERNMENT PRINTING OFFICE PI WASHINGTON PA SUPERINTENDENT DOCUMENTS,, WASHINGTON, DC 20402-9325 USA SN 1044-677X J9 J RES NATL INST STAN JI J. Res. Natl. Inst. Stand. Technol. PD JUL-AUG PY 2003 VL 108 IS 4 BP 249 EP 265 DI 10.6028/jres.108.024 PG 17 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 720JH UT WOS:000185257300001 PM 27413609 ER PT J AU Brundage, SI Schreiber, MA Holcomb, JB Zautke, N Mastrangelo, MA Xq, X Macaitis, J Tweardy, DJ AF Brundage, SI Schreiber, MA Holcomb, JB Zautke, N Mastrangelo, MA Xq, X Macaitis, J Tweardy, DJ TI Amplification of the proinflammatory transcription factor cascade increases with severity of uncontrolled hemorrhage in swine SO JOURNAL OF SURGICAL RESEARCH LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the Association-for-Academic-Surgery CY NOV 07-09, 2002 CL BOSTON, MASSACHUSETTS SP Assoc Acad Surg DE hemorrhage; shock, ischemia/reperfusion injury; trauma; interleukin-6; proinflammatory cytokines; inflammatory cascade; transcription factors; nuclear factor-kappa B; signal transducer and activator of transcription-3 (Stat3); signal transduction ID V LIVER INJURIES; INFLAMMATORY RESPONSE; SHOCK; IL-6; INTERLEUKIN-6; PHASE; MICE; IMMUNE AB Introduction. Hypotension causes diffuse liver injury accompanied by increased local production of interleukin-6 (IL-6) in swine models of uncontrolled hemorrhagic shock (HS). IL-6 is transcriptionally upregulated by nuclear factor (NF)-kappaB and results in activation of signal transducer and activator of transcription-3 (Stat3) in a murine model of controlled HS. Our objectives were: 1) to determine if increased IL-6 production and NF-kappaB and Stat3 activation occurs in a swine model of uncontrolled HS, and 2) to assess whether or not levels of IL-6 mRNA and activity of NF-kappaB and Stat3 correlate with shock severity. Materials and methods. Swine were assigned to four groups: 1) control animals (n = 6): no intervention, 2) sham operation (n = 6): celiotomy and splenectomy, 3) uncontrolled hemorrhagic shock (UHS) (n = 6): sham plus grade V vascular liver injury and resuscitation, 4) profound uncontrolled hemorrhagic shock (PUHS) (n = 8): UHS after dilutional hypothermia. Following euthanasia at 2 h, livers were harvested, total RNA isolated, and IL-6 mRNA levels quantified by Q-RT-PCR (ABI Prism 7700, Applied Biosystems International, Foster City, CA). Protein was extracted for measurement of NF-kappaB and Stat3 activity by electrophoretic mobility shift assay (EMSA). Results. Compared to shams, IL-6 mRNA levels increased 4.5-fold in UHS and 90-fold in PUHS (P < 0.001). Compared with shams; NF-kappaB activity increased 2-fold in both UHS and PUHS (P < 0.05). Stat3 activity was equivalent (not significant) in UHS when compared with shams but increased 5.3-fold in PUHS. (P < 0.05). Conclusion. These findings suggest that regional proinflammatory cytokine production results from and perpetuates a proinflammatory transcription factor cascade in a swine model of uncontrolled hemorrhagic shock and indicate that this process is proportional to the severity of shock. (C) 2003 Elsevier Inc. All rights reserved. C1 Stanford Univ, Med Ctr, Dept Surg, Palo Alto, CA 94304 USA. Oregon Hlth Sci Univ, Dept Surg, Portland, OR 97201 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Baylor Coll Med, Dept Med, Houston, TX 77030 USA. RP Brundage, SI (reprint author), Stanford Univ, Med Ctr, Dept Surg, 300 Pasteur Dr,Room H-3680, Stanford, CA 94305 USA. FU NICHD NIH HHS [K12 HD01426-01/05] NR 17 TC 16 Z9 21 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD JUL PY 2003 VL 113 IS 1 BP 74 EP 80 DI 10.1016/S0022-4804(03)00129-X PG 7 WC Surgery SC Surgery GA 717GZ UT WOS:000185080300011 PM 12943813 ER PT J AU Summers, V de Boer, E Nuttall, AL AF Summers, V de Boer, E Nuttall, AL TI Basilar-membrane responses to multicomponent (Schroeder-phase) signals: Understanding intensity effects SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID MASKING PERIOD PATTERNS; MECHANICAL WAVE-FORM; GUINEA-PIG COCHLEA; HARMONIC COMPLEXES; CHINCHILLA COCHLEA; TRAVELING-WAVE; FREQUENCY-SELECTIVITY; MOSSBAUER TECHNIQUE; IMPULSE RESPONSES; AUDITORY-NERVE AB Harmonic complexes comprised of the same spectral components in either positive-Schroeder (+Schr) or negative-Schroeder (-Schr) phase [see Schroeder, IEEE Trans. Inf. theory 16, 85-89 (1970)] have identical long-term spectra and similar waveform envelopes. However, localized patterns of basilar-membrane (BM) excitation can be quite different in response to these two stimuli. Measurements in chinchillas showed more modulated (peakier) BM excitation for +Schr than -Schr complexes [Recio and Rhode, J. Acoust. Soc. Am. 108, 2281-2298 (2000)]. In the current study, laser velocimetry was used to examine BM responses at a location tuned to approximately 17 kHz in the basal turn of the guinea-pig cochlea, for +Schr and -Schr complexes with a 203-Hz fundamental frequency. and including 10 1 equal-amplitude components from 2031 to 22 344 Hz. At 35-dB SPL, +Schr response waveforms showed greater amplitude modulation than -Schr responses. With increasing stimulation level, internal modulation decreased for both complexes. To understand the observed phenomena quantitatively, responses were predicted on the basis of a linearized model of the cochlea. Prediction was based on an "indirect impulse response" measured in the same animal. Response waveforms for Schroeder-phase signals were accurately predicted, provided that the level of the indirect impulse used in prediction closely matched the level of the Schroeder-phase stimulus. This result confirms that the underlying model, which originally was developed for noise stimuli, is valid for stimuli that produce completely different response waveforms. Moreover, it justifies explanation of cochlear filtering (i.e., differential treatment of different frequencies) in terms of a linear system. (C) 2003 Acoustical Society of America. C1 Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97201 USA. Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA. RP Summers, V (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. FU NIDCD NIH HHS [DC-00141, DC-03553] NR 37 TC 22 Z9 23 U1 0 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 2003 VL 114 IS 1 BP 294 EP 306 DI 10.1121/1.1580813 PG 13 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 699ZF UT WOS:000184087100029 PM 12880042 ER PT J AU Davis, EG MacKenzie, EJ Sacco, WJ Bain, LW Buckman, RF Champion, HR Lees, PSJ AF Davis, EG MacKenzie, EJ Sacco, WJ Bain, LW Buckman, RF Champion, HR Lees, PSJ TI A new "TRISS-like" probability of survival model for intubated trauma patients SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID INJURY SEVERITY SCORE; GLASGOW COMA SCALE; LINEAR-REGRESSION PREDICTION; MOTOR-VEHICLE CRASHES; VERBAL SCORE; CARE; REVISION; OUTCOMES; VICTIMS; NORMS AB Background. Prehospital trauma patient field intubations and paralyzations, using neuromuscular blocking agents before emergency department respiratory and neurologic assessments are made, bias assessments and outcome evaluations using probability-of-survival models, such as TRISS and A Severity Characterization of Trauma (ASCOT). We present a newly developed "TRISS-like" probability-of-survival model for intubated blunt- and penetrating-injured patient assessment. Methods: From a population of 51,397 consecutively admitted trauma patients, this study used all 5,740 (11.2% of the total injured population) intubated patients with complete data from a statewide trauma registry from October 1, 1993, to September 30, 1996. Model performance was evaluated using standard calibration and discrimination measures and z and W statistics of significance. Results:. The new model accurately predicted survival for blunt- and penetrating-injured intubated patients and is applicable to 11 etiologic patient populations. Conclusion. Study findings suggest that the new TRISS-like model should be used to assess both blunt- and penetrating-injured intubated patients. Use of this new model provides an analytical method for addressing a significant limitation of both the standard TRISS and ASCOT models, which are not applicable to intubated injured patient assessment. In addition, use of this model will complement TRISS/ASCOT assessments of nonintubated trauma patients and thus permit appropriate assessments for both intubated and nonintubated injured patient study populations. C1 Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA. Johns Hopkins Univ, Dept Environm Hlth Sci, Baltimore, MD 21205 USA. Johns Hopkins Univ, Dept Hlth Policy & Management, Baltimore, MD 21218 USA. Univ Maryland, Program Trauma, Baltimore, MD 21201 USA. Digital Innovat TriAnalyt, Forest Hill, MD 20785 USA. St Mary Hosp, Langhorne, PA 19047 USA. RP Davis, EG (reprint author), USA, Res Lab, AMSRL SL BE, Aberdeen Proving Ground, MD 21005 USA. NR 30 TC 23 Z9 25 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2003 VL 55 IS 1 BP 53 EP 60 DI 10.1097/01.TA.0000075340.22097.B5 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 753YT UT WOS:000187276500009 PM 12855881 ER PT J AU Stauffer, WM Kamat, D Magill, AJ AF Stauffer, WM Kamat, D Magill, AJ TI Traveling with infants and children. Part IV: Insect avoidance and malaria prevention SO JOURNAL OF TRAVEL MEDICINE LA English DT Review ID PLASMODIUM-FALCIPARUM MALARIA; PLACEBO-CONTROLLED TRIAL; REPELLENT N,N-DIETHYL-M-TOLUAMIDE DEET; DRUG-RESISTANT MALARIA; PERSONAL PROTECTION; IMPORTED MALARIA; VIVAX MALARIA; ANOPHELES-ARABIENSIS; FIELD-EVALUATION; DOUBLE-BLIND C1 Reg Hosp, Ctr Int Hlth & Int Travel Clin, St Paul, MN 55101 USA. Univ Minnesota, Dept Internal Med Infect Dis & Int Med, Minneapolis, MN 55455 USA. Univ Minnesota, Dept Pediat Emergency Med, Minneapolis, MN 55455 USA. W Virginia Univ, Dept Pediat, Morgantown, WV 26506 USA. Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD USA. RP Stauffer, WM (reprint author), Reg Hosp, Ctr Int Hlth & Int Travel Clin, 640 Jackson St, St Paul, MN 55101 USA. NR 126 TC 10 Z9 13 U1 0 U2 1 PU B C DECKER INC PI HAMILTON PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD JUL-AUG PY 2003 VL 10 IS 4 BP 225 EP 240 PG 16 WC Medicine, General & Internal SC General & Internal Medicine GA 705TZ UT WOS:000184412300007 PM 12946301 ER PT J AU Moul, JW AF Moul, JW TI Radical prostatectomy nomograms in black American men: Accuracy and applicability - Comment SO JOURNAL OF UROLOGY LA English DT Editorial Material ID CANCER C1 US Dept Def, Ctr Prostate Dis Res, Washington, DC 20305 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Urol Oncol, Washington, DC 20307 USA. RP Moul, JW (reprint author), US Dept Def, Ctr Prostate Dis Res, Washington, DC 20305 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUL PY 2003 VL 170 IS 1 BP 76 EP 77 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA 691FB UT WOS:000183593800015 ER PT J AU Morey, AF AF Morey, AF TI Editorial: The art of urethral reconstruction SO JOURNAL OF UROLOGY LA English DT Editorial Material ID ANTERIOR URETHROPLASTY; OUTCOME ANALYSIS C1 Brooke Army Med Ctr, Serv Urol, Ft Sam Houston, TX 78234 USA. RP Morey, AF (reprint author), Brooke Army Med Ctr, Serv Urol, Ft Sam Houston, TX 78234 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUL PY 2003 VL 170 IS 1 BP 93 EP 93 DI 10.1097/01.ju.0000072124.25045.c7 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 691FB UT WOS:000183593800022 PM 12796653 ER PT J AU Ip, K Frazier, RM Heo, YW Norton, DP Abernathy, CR Pearton, SJ Kelly, J Rairigh, R Hebard, AF Zavada, JM Wilson, RG AF Ip, K Frazier, RM Heo, YW Norton, DP Abernathy, CR Pearton, SJ Kelly, J Rairigh, R Hebard, AF Zavada, JM Wilson, RG TI Ferromagnetism in Mn- and Co-implanted ZnO nanorods SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; THIN-FILMS; ROOM-TEMPERATURE; DOPED ZNO; MAGNETIC SEMICONDUCTORS; OXIDE; SAPPHIRE; HYDROGEN; DEVICES; GROWTH AB ZnO nanorods with diameters of 15-30 nm were grown on Ag-coated Si substrates by catalyst-driven molecular beam epitaxy and then implanted with Mn+ or Co+ ions to doses of 1-5x 10(16) cm(-2). After subsequent annealing at 700 degreesC for 5 min, the structural properties of the nanorods were unaffected, but they exhibited ferromagnetism that persisted to temperatures of 225-300 K. The coercive fields were less than or equal to100 Oe even at 10 K. The results are similar to those obtained for implantation of Mn+ or Co+ ions in bulk single-crystal ZnO and indicate promise for nanorods for nanoscale spintronic applications. (C) 2003 American Vacuum Society. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Phys, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Pearton, SJ (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. NR 44 TC 91 Z9 94 U1 1 U2 7 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD JUL-AUG PY 2003 VL 21 IS 4 BP 1476 EP 1481 DI 10.1116/1.1585069 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 717GW UT WOS:000185080000050 ER PT J AU Basler, CF Mikulasova, A Martinez-Sobrido, L Paragas, J Muhlberger, E Bray, M Klenk, HD Palese, P Garcia-Sastre, A AF Basler, CF Mikulasova, A Martinez-Sobrido, L Paragas, J Muhlberger, E Bray, M Klenk, HD Palese, P Garcia-Sastre, A TI The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3 SO JOURNAL OF VIROLOGY LA English DT Article ID DOUBLE-STRANDED-RNA; PROTEASOME-MEDIATED DEGRADATION; NF-KAPPA-B; V-PROTEIN; INFLUENZA-A; VACCINIA VIRUS; IN-VIVO; TRANSCRIPTION FACTORS; VIRAL-INFECTION; ALPHA/BETA-INTERFERON AB The Ebola virus VP35 protein was previously found to act as an interferon (IFN) antagonist which could complement growth of influenza deINS1 virus, a mutant influenza virus lacking the influenza virus IFN antagonist protein, NS1. The Ebola virus VP35 could also prevent the virus- or double-stranded RNA-mediated transcriptional activation of both the beta IFN (IFN-beta) promoter and the IFN-stimulated ISG54 promoter (C. Basler et al., Proc. Natl. Acad. Sci. USA 97:12289-12294, 2000). We now show that VP35 inhibits virus infection-induced transcriptional activation of IFN regulatory factor 3 (IRF-3)-responsive mammalian promoters and that VP35 does not block signaling from the IFN-alpha/beta receptor. The ability of VP35 to inhibit this virus-induced transcription correlates with its ability to block activation of IRF-3, a cellular transcription factor of central importance in initiating the host cell IFN response. We demonstrate that VP35 blocks the Sendai virus-induced activation of two promoters which can be directly activated by IRF-3, namely, the ISG54 promoter and the ISG56 promoter. Further, expression of VP35 prevents the IRF-3-dependent activation of the IFN-alpha4 promoter in response to viral infection. The inhibition of IRF-3 appears to occur through an inhibition of IRF-3 phosphorylation. VP35 blocks virus-induced IRF-3 phosphorylation and subsequent IRF-3 dimerization and nuclear translocation. Consistent with these observations, Ebola virus infection of Vero cells activated neither transcription from the ISG54 promoter nor nuclear accumulation of IRF-3. These data suggest that in Ebola virus-infected cells, VP35 inhibits the induction of antiviral genes, including the IFN-beta gene, by blocking IRF-3 activation. C1 CUNY Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA. USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. Univ Marburg, Inst Virol, D-35037 Marburg, Germany. RP Basler, CF (reprint author), CUNY Mt Sinai Sch Med, Dept Microbiol, 1 Gustave L Levy Pl, New York, NY 10029 USA. OI Palese, Peter/0000-0002-0337-5823; Muhlberger, Elke/0000-0003-3547-9376; Garcia-Sastre, Adolfo/0000-0002-6551-1827 NR 98 TC 281 Z9 299 U1 16 U2 58 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUL PY 2003 VL 77 IS 14 BP 7945 EP 7956 DI 10.1128/JVI.77.14.7945-7956.2003 PG 12 WC Virology SC Virology GA 696QX UT WOS:000183899200026 PM 12829834 ER PT J AU Stiles, KP Moffatt, MJ Agodoa, LY Swanson, SJ Abbott, KC AF Stiles, KP Moffatt, MJ Agodoa, LY Swanson, SJ Abbott, KC TI Renal cell carcinoma as a cause of end-stage renal disease in the United States: Patient characteristics and survival SO KIDNEY INTERNATIONAL LA English DT Article DE renal cell carcinoma; nephrectomy; Caucasian; male; transplantation; complications; dialysis; USRDS; age ID POLYCYSTIC KIDNEY-DISEASE; RADICAL NEPHRECTOMY; PROGNOSTIC-SIGNIFICANCE; BILATERAL-NEPHRECTOMY; TRANSPLANTATION; DIALYSIS; CANCER; ERYTHROPOIETIN; GRADE; PREDICTION AB Background. The patient characteristics and mortality associated with renal cell carcinoma (RCC) as a cause of end-stage renal disease (ESRD) have not been characterized for a national population. Methods. An historical cohort study of renal cell carcinoma (RCC) was conducted from April 1, 1995, to December 31, 1999. Included were 360,651 patients in the United States Renal Data System (USRDS) who were initiated on ESRD therapy with valid causes of ESRD. Results. Of the study population, 1646 patients (0.5%) had RCC. The mean age of patients with RCC was 66.8 +/- 14.6 years versus 61.3 +/- 16.4 years for patients with other causes of ESRD (P < 0.01 by Student t test). The unadjusted 3-year survival (censored at the date of renal transplantation) of patients with RCC during the study period was 23% versus 36% in all other patients [adjusted hazard ratio (AHR), 1.10, 95% confidence interval (CI) 1.02-1.19, P = 0.019 by Cox regression]. However, patients with RCC who underwent nephrectomy (bilateral or unilateral) had significantly better survival compared to RCC patients who did not (AHR, 0.73, 95% Cl, 0.63-0.85, P < 0.01), and their survival was not significantly different in comparison with nondiabetic ESRD patients. Bilateral nephrectomy (vs. unilateral) was not associated with any difference in adjusted mortality. Conclusion. Among patients with ESRD, the demographics of those with RCC were similar to those of patients with RCC in the general population. Overall, patients with RCC had decreased survival compared to patients with other causes of ESRD; those who underwent nephrectomy had significantly better survival than those who did not, with survival comparable to patients with nondiabetic ESRD. C1 Madigan Army Med Ctr, Serv Nephrol, Ft Lewis, WA USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. NIDDK, Bethesda, MD USA. NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, MC Nephrol Serv, Washington, DC 20307 USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 44 TC 12 Z9 14 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD JUL PY 2003 VL 64 IS 1 BP 247 EP 253 DI 10.1046/j.1523-1755.2003.00060.x PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 690KH UT WOS:000183547500029 PM 12787416 ER PT J AU Burgess, EB AF Burgess, EB TI Absolutely American: Four years at West Point. SO LIBRARY JOURNAL LA English DT Book Review C1 Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2003 VL 128 IS 12 BP 105 EP 105 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 696VL UT WOS:000183908200211 ER PT J AU Wang, SQ Bigelow, RA Markiewicz, RS Giessen, GC AF Wang, SQ Bigelow, RA Markiewicz, RS Giessen, GC TI Magnetic-alignment properties of REBa2Cu4O8 (RE=Ho, Er) SO MATERIALS LETTERS LA English DT Article DE REBa2Cu4O8; Er-124; biaxial alignment ID ATMOSPHERE OXYGEN-PRESSURE; BIAXIAL ALIGNMENT; SUPERCONDUCTOR POLYCRYSTALS; YBA2CU4O8; ORIENTATION AB Polycrystalline REBa2Cu4O8 (RE-124) high-temperature cuprate superconductors synthesized at 1 atm oxygen pressure using nitrates as starting materials were magnetically aligned in an 8 T vertical magnetic field; here, RE=Ho, Er. XRD Theta-2Theta and %-circle scans demonstrated that the grains of Ho-124 align with their c axes parallel to the magnetic field while the grains of Er-124 were oriented to lie with their b axes parallel to the field direction, which, therefore, indicates that Er-124 is a candidate for biaxial alignment. The successful simplified synthesis of new Er-doped 124 phase and the characterization of its normal magnetic alignment behavior are of great significance for biaxial alignment of the 124 phase to fabricate biaxially aligned Er-124 thick films as substrates for growth of epitaxial YBCO superconductor thin films. (C) 2003 Elsevier Science B.V. All rights reserved. C1 Northeastern Univ, Dept Chem, Boston, MA 02115 USA. Northeastern Univ, Barnett Inst, Boston, MA 02115 USA. Willamette Univ, Dept Phys, Salem, OR 97301 USA. Northeastern Univ, Dept Phys, Boston, MA 02115 USA. RP Wang, SQ (reprint author), USA, Res Lab, SNHC, 80 Scott Dr, Hanscom AFB, MA 01731 USA. NR 14 TC 0 Z9 0 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X J9 MATER LETT JI Mater. Lett. PD JUL PY 2003 VL 57 IS 22-23 BP 3449 EP 3454 DI 10.1016/S0167-577X(03)00098-3 PG 6 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 699HJ UT WOS:000184050700028 ER PT J AU Woodard, SC AF Woodard, SC TI The story of the mobile army surgical hospital SO MILITARY MEDICINE LA English DT Article AB The critical task of the physician uniting effective surgical intervention within close proximity to the front lines, and therefore the wounded, must be matched with the challenge of not becoming a casualty as well. The U.S. Army Medical Services during the Korean War balanced the surgeon's ability to protect himself and save others. This article tells the story of perhaps one of the most characteristically highlighted medical aspects of the Korean War, the Mobile Army Surgical Hospital. Originally intended to be close to the front lines of fighting, the Mobile Army Surgical Hospital was equipped to move on its own. Initially, the unit was formed to provide surgical capabilities for one division. It transformed through the course of the war into a multidivision and multinational all-purpose hospital. With this expansion in workload (medical cases in addition to surgery) without an equitable increase in personnel, rapid evacuation of patients was the only means of keeping up. C1 AMEDDC&S, Leader Training Ctr, Support Operat Branch, Ft Sam Houston, TX 78234 USA. RP Woodard, SC (reprint author), 249th Gen Hosp, Med Command 44, Ft Gordon, GA 30905 USA. NR 62 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2003 VL 168 IS 7 BP 503 EP 513 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 743AM UT WOS:000186550300002 PM 12901456 ER PT J AU Staudenmeier, JJ Bacon, BL Ruiz, RT Diebold, CJ AF Staudenmeier, JJ Bacon, BL Ruiz, RT Diebold, CJ TI Anthrax refusers: A 2nd Infantry Division perspective SO MILITARY MEDICINE LA English DT Article AB The Department of Defense anthrax vaccination program has been in the news often recently. Concerns are cited over the safety and usefulness of the vaccine. This brief report describes some of the characteristics of anthrax vaccine refusers. This report examines the implementation of an anthrax vaccination program in a well-disciplined, forward-deployed Army unit facing a hostile enemy with access to anthrax biological warfare stocks. C1 Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. USAAMC, Ft Rucker, AL 36362 USA. RP Staudenmeier, JJ (reprint author), Tripler Army Med Ctr, Dept Psychiat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2003 VL 168 IS 7 BP 520 EP 522 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 743AM UT WOS:000186550300004 PM 12901458 ER PT J AU Bodey, TE Loushine, RJ West, LA AF Bodey, TE Loushine, RJ West, LA TI A retrospective study evaluating the use of the panoramic radiograph in endodontics SO MILITARY MEDICINE LA English DT Article AB Patients are referred to the endodontist to have root canal therapy performed to treat pulpal and periradicular diseases. Routinely, the only radiograph to accompany the patient is the periapical radiograph. This radiograph is inadequate in the detection of asymptomatic pathosis that may be present in other areas of the maxilla and mandible. The military's readiness mission requires that a panoramic radiograph be part of the patient's dental record. In addition to its use for personal identification purposes, the panoramic radiograph is an excellent diagnostic tool that can give the clinician an overall view of the dentoalveolar structures. This retrospective study evaluated randomly selected panoramic radiographs and recorded the presence of radiolucent and radiopaque areas not evident on a referral periapical radiograph. The results of this study found a 4.2% occurrence of undiagnosed pathosis following additional radiographs and clinical examinations. C1 USA, Dent Activ, Endodont Dept, Tingay Dent Clin, Ft Gordon, GA 30905 USA. RP Bodey, TE (reprint author), USA, Dent Activ, Endodont Dept, Tingay Dent Clin, Ft Gordon, GA 30905 USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2003 VL 168 IS 7 BP 528 EP 529 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 743AM UT WOS:000186550300006 PM 12901460 ER PT J AU Parr, RR Providence, BC Burkhalter, WE Smith, AC AF Parr, RR Providence, BC Burkhalter, WE Smith, AC TI Treatment of lower extremity injuries due to antipersonnel mines: Blast resuscitation and victim assistance team experiences in Cambodia SO MILITARY MEDICINE LA English DT Article ID INTERNATIONAL-COMMITTEE; RED-CROSS; AMPUTATIONS; WAR AB The two teams comprising the fiscal year 2001 Blast Resuscitation and Victim Assistance mission had the opportunity to learn from and practice mine injury treatment principles with experienced local and international war surgeons in Cambodia. Treatment principles were modifications of International Committee of the Red Cross recommendations. A total of 14 acute lower extremity mine injuries were treated. Surgery generally consisted of an open amputation or thorough irrigation and debridement using equipment readily available in any U.S. military field hospital. The surgical techniques will be described in detail. Delayed primary closure occurred 5 days later followed by prosthesis fitting (for amputees) in an International Committee of the Red Cross facility 12 weeks later. Other options and techniques will be discussed with an emphasis on applicability to U.S. military field surgery. C1 Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Plast Surg Serv, Honolulu, HI 96859 USA. RP Parr, RR (reprint author), Tripler Army Med Ctr, Orthopaed Surg Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 17 TC 1 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2003 VL 168 IS 7 BP 536 EP 540 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 743AM UT WOS:000186550300008 PM 12901462 ER PT J AU Chaffin, J Marburger, T Fretwell, LD AF Chaffin, J Marburger, T Fretwell, LD TI Dental class 3 intercept clinic: A model for treating dental class 3 soldiers SO MILITARY MEDICINE LA English DT Article ID EMERGENCIES; READINESS; IMPACT AB Objective: Dental Fitness Classification (DFC) 3 indicates that a soldier has a dental condition that, if not treated, is expected to result in a dental emergency within 12 months. Forty-two percent of Army recruits have DFC 3 conditions as reported by the 2000 Tri-Service Center Recruit Study. Initial entry training schools allow minimal time for dental care. The Fort Hood Class Three Intercept Clinic (CTIC) was created to treat DFC 3 conditions prior to soldiers being assigned to their units. The purpose of this study was to evaluate CTIC's ability to make soldiers dentally deployable before joining their new units at Fort Hood, Texas. Materials and Methods: A retrospective review of the CTIC daily sign-in logs for the period of January 1999 to May 2001 was used to identify DFC 3 soldiers. The data were analyzed to determine frequency of DFC 3 by rank, DFC after CTIC visits, distribution of treatment type needed to establish dental readiness, and to identify soldiers whose DFC 3 conditions were not treated. Additionally, for the 6 months between November 2000 and April 2001, all soldiers who remained a DFC 3 when released to their units were followed to assess how long it took for them to attain a DFC 1 or 2 status. Results: The retrospective review of the CTIC records identified 5,851 DFC 3 soldiers who in-processed to Fort Hood from January 1999 to May 2001. CTIC successfully converted 86.9% (N = 5,083) of the soldiers to DFC 1 or 2. Of a sample of 185 DFC 3 soldiers released to their units as a DFC 3, only 54% had converted to DFC 1 or 2, with 60.5 days being the mean days to convert. Conclusions: Trainees have large demands for dental care with minimal time to seek treatment during Initial Entry Training. A CTIC, or hybrid, can provide the necessary emergent dental care to remove soldiers from DFC 3 prior to their being assigned to their first permanent duty station. C1 USA, Dent Corps, Ft Hood, TX 76544 USA. USA, Dent Corps, AMEDD Ctr & Sch, Dent Sci Div, Ft Sam Houston, TX 78234 USA. USA, Dent Command, Dent Corps, Ft Sam Houston, TX 78234 USA. RP Chaffin, J (reprint author), USA, Dent Corps, Ft Hood, TX 76544 USA. NR 11 TC 3 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2003 VL 168 IS 7 BP 548 EP 552 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 743AM UT WOS:000186550300011 ER PT J AU Verma, PS Gallagher, CM AF Verma, PS Gallagher, CM TI Dyspnea on exertion, fatigue, and pallor in a 50-year-old active duty soldier SO MILITARY MEDICINE LA English DT Article ID APLASTIC-ANEMIA; TRANSFUSIONS; DISEASE; TRIAL AB Objective: To discuss a comprehensive diagnostic approach to an active duty patient presenting with dyspnea on exertion, fatigue, and pallor. A 50-year-old active duty E-6 white male in Al Udeid, Qatar, presented with progressive dyspnea on exertion, fatigue, and new pallor. This case illustrates the course of events from Al Udeid to the Walter Reed Army Medical Center, where the final diagnosis was made. Along the way, questions with discussions explore the various diagnostic and management aspects of his case and highlight military relevant issues that include efficient diagnostic algorithms in the field and transfusion of scarce blood products. C1 Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. RP Verma, PS (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 12 TC 0 Z9 0 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2003 VL 168 IS 7 BP 587 EP 590 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 743AM UT WOS:000186550300019 PM 12901473 ER PT J AU Vasconcelos, OM Harter, DH Duffy, C McDonough, B Seidman, JG Seidman, CE Campbell, WW AF Vasconcelos, OM Harter, DH Duffy, C McDonough, B Seidman, JG Seidman, CE Campbell, WW TI Adult Hallervorden-Spatz syndrome simulating amyotrophic lateral sclerosis SO MUSCLE & NERVE LA English DT Article DE amyotrophic lateral sclerosis; Hallervorden-Spatz syndrome; motor neuron disease; neurodegeneration with brain iron accumulation type 1 (NBIA-1); neurodegenerative disorder; pantothenate kinase gene type 2 (PANK2) ID ALPHA-SYNUCLEIN; DISEASE; MR AB Hallervorden-Spatz syndrome (HSS) is a neurodegenerative disorder characterized by progressive dementia, dystonia, ataxia, and rigidity. An atypical form of adult-onset HSS was observed in a 36-year-old man presenting with progressive dysarthria. Markedly dysarthric speech and a weak atrophic tongue associated with a neurogenic pattern of motor unit recruitment in bulbar-supplied muscles on electromyography led to an initial impression of bulbar amyotrophic lateral sclerosis (ALS). Lack of expected progression of symptoms, however, prompted reinvestigation. Repeat brain magnetic resonance imaging demonstrated an "eye-of-the-tiger" pattern in the basal ganglia, characteristic of HSS, thus requiring genetic studies. DNA analyses of the pantothenate kinase gene (PANK2) was conducted and revealed two novel, disease-causing exon 3 missense mutations (Cys231Ser and Tyr251Cys). This case broadens the genotypic and phenotypic spectrum of HSS to include a late-onset syndrome resembling bulbar-onset ALS. C1 Virginia Commonwealth Univ, Med Coll Virginia, Dept Neurol, Richmond, VA 23284 USA. George Washington Univ, Sch Med & Hlth Sci, Washington, DC USA. Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA USA. Harvard Univ, Sch Med, Dept Genet, Boston, MA USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. RP Campbell, WW (reprint author), Virginia Commonwealth Univ, Med Coll Virginia, Dept Neurol, Med Coll Virginia Campus, Richmond, VA 23284 USA. NR 19 TC 18 Z9 19 U1 0 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD JUL PY 2003 VL 28 IS 1 BP 118 EP 122 DI 10.1002/mus.10389 PG 5 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 696HH UT WOS:000183881200016 PM 12811783 ER PT J AU Gray, JB Wentworth, TR Brownie, C AF Gray, JB Wentworth, TR Brownie, C TI Extinction, colonization, and persistence of rare vascular flora in the longleaf pine-wiregrass ecosystem: Responses to fire frequency and population size SO NATURAL AREAS JOURNAL LA English DT Article DE rare species; fire frequency; longleaf pine; extinction; colonization ID SEASON PRESCRIBED FIRE; TIME-SINCE-FIRE; PLANTS; DEMOGRAPHY; VEGETATION; DYNAMICS; SAVANNAS; DENSITY; FORESTS; PRAIRIE AB We examined factors likely to be important in management of rare flora of the longleaf pine-wiregrass ecosystem on Fort Bragg and Camp Mackall Military Reservations in North Carolina, USA. We documented 1.268 occurrences of thirty-six rare plant species during two inventories conducted from 1991 to 1993 and 1998 to 1999. Of these occurrences, 891 (70.3%) persisted, 258 (20.3%) went extinct, and 119 (9.4%) colonized between the first and second inventories; extinctions exceeded colonizations by 139 occurrences. We used analyses of contingency table frequencies and logistic regressions to test hypotheses about temporal responses of local occurrences of rare flora. We found statistically significant effects of fire frequency on the colonization and extinction of rare flora; extinctions declined and colonizations increased with increasing fire frequency. There were statistically significant effects of both area occupied and stem number on the persistence and extinction of rare flora; extinctions declined and persistences increased with increasing area occupied and stem number. Our analyses emphasize the importance of fire and population size for the conservation of rare flora in this landscape. C1 Ft Bragg Mil Reservat N Carolina, Ft Bragg, NC 28310 USA. N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA. N Carolina State Univ, Dept Bot, Raleigh, NC 27695 USA. RP Gray, JB (reprint author), Ft Bragg Mil Reservat N Carolina, Ft Bragg, NC 28310 USA. EM grayjb@bragg.army.mil NR 37 TC 16 Z9 16 U1 1 U2 14 PU NATURAL AREAS ASSOCIATION PI ROCKFORD PA 320 SOUTH THIRD STREET, ROCKFORD, IL 61104 USA SN 0885-8608 J9 NAT AREA J JI Nat. Areas J. PD JUL PY 2003 VL 23 IS 3 BP 210 EP 219 PG 10 WC Ecology; Forestry SC Environmental Sciences & Ecology; Forestry GA 901OB UT WOS:000227290700004 ER PT J AU Weldon, PJ Aldrich, JR Klun, JA Oliver, JE Debboun, M AF Weldon, PJ Aldrich, JR Klun, JA Oliver, JE Debboun, M TI Benzoquinones from millipedes deter mosquitoes and elicit self-anointing in capuchin monkeys (Cebus spp.) SO NATURWISSENSCHAFTEN LA English DT Article ID INSECTS AB Neotropical monkeys of the genus Cebus anoint themselves by rubbing arthropods and plants against their pelage. A recent study has shown that free-ranging wedge-capped capuchin monkeys (C. olivaceus) in Venezuela self-anoint with a benzoquinone-secreting millipede, an activity by which they are hypothesized to appropriate chemical deterrents of mosquitoes. To evaluate the plausibility of this hypothesis, female yellow fever mosquitoes (Aedes aegypti) were presented with two millipede secretory compounds, 2-methyl-1,4-benzoquinone and 2-methoxy-3-methyl-1,4-benzoquinone, on nylon-reinforced silicone membranes placed over wells filled with human blood, a highly preferred food. Mosquitoes exhibited fewer landings, fed less frequently, and flew more frequently (a possible indication of repellency) in the presence of membranes treated with benzoquinones than with controls. These compounds also elicit self-anointing in captive male and female tufted (C. apella) and white-faced (C. capucinus) capuchin monkeys. C1 ARS, Chem Affecting Insect Behav Lab, USDA, Beltsville, MD 20705 USA. Smithsonian Inst, Conservat & Res Ctr, Front Royal, VA 22630 USA. Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Washington, DC 20307 USA. RP Aldrich, JR (reprint author), ARS, Chem Affecting Insect Behav Lab, USDA, Beltsville, MD 20705 USA. NR 25 TC 39 Z9 41 U1 0 U2 14 PU SPRINGER-VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 USA SN 0028-1042 J9 NATURWISSENSCHAFTEN JI Naturwissenschaften PD JUL PY 2003 VL 90 IS 7 BP 301 EP 304 DI 10.1007/s00114-003-0427-2 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 703UC UT WOS:000184298500002 PM 12883771 ER PT J AU Armstrong, PJ Franklin, DP AF Armstrong, PJ Franklin, DP TI Treatment of vascular injuries in the multiple-ligament-injured knee SO OPERATIVE TECHNIQUES IN SPORTS MEDICINE LA English DT Article DE popliteal vascular injury; knee trauma ID POPLITEAL ARTERY TRAUMA; LOWER-EXTREMITY TRAUMA; COMPLETE DISLOCATION; VENOUS INJURIES; LIMB SALVAGE; SELECTIVE ARTERIOGRAPHY; PHYSICAL-EXAMINATION; FREE-RADICALS; BLUNT; MANAGEMENT AB Popliteal vascular injury associated with the multiple-ligament-injured knee, including knee dislocation, continues to be an uncommon but morbid injury. The tethering of the popliteal vessels to the femur at Hunter's canal and to the tibia by the soleus muscle allows for significant vascular injury when the supporting ligamentous structure is disrupted. The majority of injuries are related to motor vehicle accidents, including driver and passenger injuries, motor vehicle versus pedestrian injuries (bumper injuries), and motorcycle accidents. The mechanisms of vascular injury, both artery and vein, include stretching that results in intimal injury, contusion, laceration, transection, or avulsion. A high index of suspicion must be maintained in the evaluation of these injuries. Modes of evaluation include physical examination, ankle brachial indices, duplex examination, magnetic resonance imaging, and angiography. Given the potentially devastating consequence of a missed popliteal artery injury, routine arteriography or serial physical examination with duplex examination is recommended for patients with a multiple-ligament-injured knee. Vascular repair to include primary repair, patch angioplasty, or interposition grafting is performed from either a medial or posterior approach. Adjunctive measures include 4-compartment fasciotomy, mannitol administration, and vasodilator therapy. Several controllable factors have been found to improve limb salvage, such as decreased ischemia time, systemic anticoagulation, and 4-compartment fasciotomy. Prompt recognition of vascular injury, prompt restoration of flow, and use of proven adjuncts provides the optimal possibility of limb salvage with popliteal artery injuries associated with the multiple-ligament-injured knee. C1 Geisinger Med Ctr, Vasc Surg Sect, Danville, PA 17822 USA. Brooke Army Med Ctr, Peripheral Vasc Surg Serv, Ft Sam Houston, TX 78234 USA. RP Franklin, DP (reprint author), Geisinger Med Ctr, Vasc Surg Sect, 100 N Acad Dr, Danville, PA 17822 USA. NR 65 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 1060-1872 J9 OPER TECHN SPORT MED JI Oper. Tech. Sports Med. PD JUL PY 2003 VL 11 IS 3 BP 199 EP 207 DI 10.1053/otsm.2003.35919 PG 9 WC Sport Sciences; Surgery SC Sport Sciences; Surgery GA 710AF UT WOS:000184658100005 ER PT J AU Driggers, RG Ratches, JA Leachtenauer, JC Kistner, RW AF Driggers, RG Ratches, JA Leachtenauer, JC Kistner, RW TI Synthetic aperture radar target acquisition model based on a National Imagery Interpretability Rating Scale to probability of discrimination conversion SO OPTICAL ENGINEERING LA English DT Article DE synthetic aperture radar; imagery performance modeling; National Imagery Interpretability Rating Scale; image quality ID QUALITY EQUATION; RECOGNITION AB Previous efforts have established models that relate IR and visible imaging sensor design and operating parameter values to measures of information extraction performance. The surveillance and reconnaissance community predicts National Imagery Interpretability Rating Scale (NIIRS) values using the general image quality equation (GIQE). The target acquisition community predicts probabilities of discrimination (detection, recognition, identification) using various minimum resolvable contrast/minimum resolvable temperature (MRC/MRT) models, and methods have been developed to link the two sets of predictions. No such models currently exist for the radar domain, although a radar NIIRS has been developed. We provide a basis for initial estimates of synthetic aperture radar (SAR) target acquisition performance. First, a conversion from radar to IR (and visible) NIIRS is provided. The IR NIIRS is then converted to probabilities of discrimination values. The two conversions together provide rough estimates of SAR target acquisition performance as a function of radar NIIRS values. (C) 2003 Society of Photo-Optical Instrumentation Engineers. C1 USA, Electoopt & Photon Div, Res Lab, AMSRL SE E, Adelphi, MD 20783 USA. USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. J M Leachtenauer Associates Inc, Charlottesville, VA 22901 USA. USA, Mat Syst Anal Act, Aberdeen Proving Ground, MD 21005 USA. RP Driggers, RG (reprint author), USA, Electoopt & Photon Div, Res Lab, AMSRL SE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 17 TC 7 Z9 8 U1 0 U2 3 PU SPIE-INT SOCIETY OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUL PY 2003 VL 42 IS 7 BP 2104 EP 2112 DI 10.1117/1.1580831 PG 9 WC Optics SC Optics GA 700HL UT WOS:000184106500037 ER PT J AU Payne, SC Finch, JF Tremble, TR AF Payne, SC Finch, JF Tremble, TR TI Validating surrogate measures of psychological constructs: The application of construct equivalence to archival data SO ORGANIZATIONAL RESEARCH METHODS LA English DT Article DE surrogate measures; construct equivalence; archival data; secondary analysis ID MULTITRAIT-MULTIMETHOD MATRIX; ORGANIZATIONAL COMMITMENT; MAXIMUM-LIKELIHOOD; JOB-SATISFACTION; TESTS; VALIDITY; MODELS; METAANALYSIS; CONTINUANCE; ANTECEDENTS AB Archival data present opportunities to test important research questions. Unfortunately, archival data do not always include validated measures of the psychological constructs that may be of interest to researchers. In this article, the authors describe how the construct equivalence approach can be applied to organizational archival data to derive and empirically validate surrogate measures of psychological constructs. A step-by-step explanation of how to validate such measures, which includes the use of confirmatory factor analysis to examine the data from a multitrait-multimethod perspective, is described. This approach facilitates the use of organizational archives for research purposes. C1 Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA. USA, Res Inst Behav & Social Sci, Washington, DC 20330 USA. RP Payne, SC (reprint author), Texas A&M Univ, Dept Psychol, 4235 TAMU, College Stn, TX 77843 USA. NR 66 TC 3 Z9 3 U1 22 U2 33 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1094-4281 J9 ORGAN RES METHODS JI Organ. Res. Methods PD JUL PY 2003 VL 6 IS 3 BP 363 EP 382 DI 10.1177/1094428103254455 PG 20 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 695XH UT WOS:000183855300005 ER PT J AU Izraelevitz, D AF Izraelevitz, D TI A fast algorithm for approximate viewshed computation SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article ID VISIBILITY AB Given a terrain model, the viewshed from a viewpoint is computed as the set of X-Y positions of a point target such that the target is visible. We introduce a novel approach to the computation of accurate viewshed approximations. Our algorithm relies on the computation of an approximation to the so-called line-of-sight (LOS) function. This function is defined over target X-Y positions, and is the highest elevation of a target so that it is still occluded from the viewpoint. The LOS function summarizes intervisibility information and permits reuse of previous intervisibility computations, resulting in computational efficiencies. Our algorithm gives results very close to the traditional sightline ray method at a substantially smaller computational cost, and is a generalization of the approach developed by Franklin and Ray for the some problem. We describe in detail the application to gridded terrain models, but the approach is similarly applicable to other elevation models. C1 USA, TEC, Ctr Res Dev & Engn, Corps Engineers, Los Alamos, NM 87544 USA. SRI Int, Los Alamos, NM 87544 USA. RP Izraelevitz, D (reprint author), USA, TEC, Ctr Res Dev & Engn, Corps Engineers, 660 Totavi St, Los Alamos, NM 87544 USA. EM david.izraelevitz@sri.com NR 12 TC 9 Z9 9 U1 0 U2 2 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD JUL PY 2003 VL 69 IS 7 BP 767 EP 774 PG 8 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA 817RC UT WOS:000221193600003 ER PT J AU Babincova, M Sourivong, P Leszczynska, D Babinec, P AF Babincova, M Sourivong, P Leszczynska, D Babinec, P TI Fullerenosomes: Design of a novel nanomaterial for laser controlled topical drug release SO PHYSICA MEDICA LA English DT Article DE C60; fullerenosomes; controlled drug release; cancer therapy; infrared laser ID MAGNETIC-FIELD; MAGNETOLIPOSOMES; LIPOSOMES; DECOMPOSITION; ABSORPTION; DYE AB Phosphatidylcholine liposomes were prepared with encapsulated 6-carboxyfluorescein and C-60 fullerene incorporated in their lipid bilayers. This so called fullerenosome system was evaluated for its feasibility of using laser as a triggering mechanism for the release of drugs. Substantial amount of carboxyfluorescein was released even in response to a single near-infrared nanosecond laser pulse with wavelength 1064 nm. Indirectly has been shown that these effects are probably due to the fullerene-mediated localized temperature increase, and CO2 and free radical production. C1 Comenius Univ, Dept Biophys & Chem Phys, Bratislava 84248, Slovakia. USA, HPPM, Hlth Phys Program, Aberdeen Proving Ground, MD 21010 USA. FSU, FAMU, Coll Engn, Dept Civil Engn, Tallahassee, FL 32310 USA. Jackson State Univ, Dept Chem, CCMSI, Jackson, MS 39217 USA. RP Babincova, M (reprint author), Comenius Univ, Dept Biophys & Chem Phys, Mlynska Dolina F1, Bratislava 84248, Slovakia. OI Babinec, Peter/0000-0002-4424-3376 NR 23 TC 8 Z9 8 U1 0 U2 4 PU ISTITUTI EDITORIALI E POLGRAFICI INTERNAZIONALI PI PISA PA CASELLA POSTALE N 1, SUCCURSALE N 8, 56123 PISA, ITALY SN 1120-1797 J9 PHYS MEDICA JI Phys. Medica PD JUL-SEP PY 2003 VL 19 IS 3 BP 213 EP 216 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 745VY UT WOS:000186712400002 ER EF