FN Thomson Reuters Web of Science™ VR 1.0 PT B AU Kecskes, LJ Edwards, BT Woodman, RH AF Kecskes, Laszlo J. Edwards, Brian T. Woodman, Robert H. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Hafnium-based bulk metallic glasses for kinetic energy penetrators SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID FORMING ABILITY; BEHAVIOR; ALLOYS AB A new family of quinary, hafnium-based, bulk-metallic-glass-forming alloys has been developed for use in composite kinetic-energy penetrators. The alloys are based on an invariant point identified in the hafnium-copper-nickel ternary system. They are denser than zirconium-based glass-forming compositions, and exhibit a higher reduced glass-transition temperature than alloys prepared by 1:1 hafnium substitution into the zirconium-based alloys. The combination of density and glass-forming ability exhibited by this alloy moves the composite technology closer to being a viable substitute for depleted-uranium penetrators. C1 USA, Weap & Mat Technol Directorate, AMSRD, ARL,WMMB,Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Kecskes, LJ (reprint author), USA, Weap & Mat Technol Directorate, AMSRD, ARL,WMMB,Res Lab, Aberdeen Proving Ground, MD 21005 USA. RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 11 TC 0 Z9 0 U1 0 U2 6 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 257 EP + DI 10.1142/9789812772572_0033 PG 8 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200033 ER PT B AU Knerr, BW Garrity, PJ Lampton, DR AF Knerr, Bruce W. Garrity, Patrick J. Lampton, Donald R. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Embedded training for future force warriors: An assessment of wearable virtual simulators SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary AB Embedded virtual simulation has the potential to provide more realistic and effective training for dismounted Soldiers, particularly in operations in urban areas, and in the operation and tactics, techniques and procedures for using Future Force systems. This paper describes an assessment of wearable virtual simulators (WSs) for Infantry Soldiers. The assessment focused on the capabilities and limitations of the WSs as they were used by Soldiers in a realistic training situation: the capability to support the performance of Soldier tasks, side effects, and human interface issues. Three vendors developed different WSs. Each was based on the Quantum 3D Thermite wearable computer, but the vendors used different software and interface hardware. Each permitted a Soldier to view a simulated virtual environment and to interact with other simulated and real entities within it. The SVS, an immersive but non-wearable 3D virtual simulator was used for comparison purposes and to provide enough simulators to fill out a full Infantry squad. OneSAF TestBed was used to provide a simulated enemy force and civilians. Six WS, four SVSs, the Dismounted Infantry Virtual After Action Review System (DIVAARS), and OneSAF were networked to provide a collective training situation in a shared environment. Squads of Soldiers each participated in a series of simulated tactical exercises using the simulators. They then completed questionnaires to report simulator sickness symptoms and to rate the ease with which they could perform 54 Soldier tasks in the simulator. The WSs were able to connect with each other and the SVSs. The major drawbacks to the use of WSs for training appear to be the current lack of graphic processing power of the Thermite computer. Reliability was also a problem. The activities that Soldiers reported they could perform well did not differ substantially from those reported previously with the SVS. The more highly rated tasks consisted of identification of types of people and tactically significant areas, imprecise movement, and communication. The lower rated tasks consisted of precise or rapid movement, distance estimation, and locating the source of enemy fire using either visual or auditory cues. Most of the problems identified should be correctible in the near term. C1 USA, Res Inst Behav & Social Sci, Orlando, FL 32826 USA. RP Knerr, BW (reprint author), USA, Res Inst Behav & Social Sci, Orlando, FL 32826 USA. NR 4 TC 0 Z9 0 U1 1 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 315 EP + DI 10.1142/9789812772572_0040 PG 9 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200040 ER PT B AU Lickteig, CW Sanders, WR Lussier, JW Durlach, PJ AF Lickteig, Carl W. Sanders, William R. Lussier, James W. Durlach, Paula J. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Measurement of human performance for Future Combat Systems command and control SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary AB Historically, Army acquisition has had difficulty conducting an adequate early assessment of the human dimension in system performance. Proactive research on human performance, however, is vital to achieving the unprecedented alliance of humans and machines anticipated with Future Combat Systems (FCS). This paper summarizes research methods and findings across four exploratory experiments focused on the command group of a small combined arms unit composed primarily of unmanned air and ground vehicles. Results are based on highly detailed objective measures of verbal and human-computer interaction and an array of subjective measures from expert and novice participants. Findings underscore potential problems in training and workload with FCS, and potential solutions through user-based involvement and proactive research to ensure technology complements human performance. C1 USA, Res Inst Behav & Social Sci, Ft Knox, KY 40120 USA. RP Lickteig, CW (reprint author), USA, Res Inst Behav & Social Sci, Ft Knox, KY 40120 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 351 EP + DI 10.1142/9789812772572_0045 PG 9 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200045 ER PT B AU Kerick, SE Allender, LE AF Kerick, S. E. Allender, L. E. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Effects of cognitive workload on decision accuracy, shooting performance, and cortical activity of soldiers SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary AB The purpose of this research was to investigate dynamic cortical processes of soldiers during simulated shooting scenarios as a function of task demand. Task demand was varied among three two-level factors: task load (single, dual), decision load (no-decision, decision), and target exposure time (short, long). Dependent variables were measured at subjective, behavioral, and physiological levels. Subjective measures were self-reports of workload and stress, behavioral measures were primary and secondary task performance, and physiological measures were event-related spectral perturbation (ERSP, where event-related refers to target onset times) in theta (4-7 Hz) and alpha (11-13 Hz) frequency bands. Results from analyses of the subjective report data revealed that time stress and decision load main effects significantly influenced workload perceptions. Analyses of the shooting performance data revealed that the time stress main effect was significant for decision accuracy, shooting accuracy, and response time, and analyses of secondary task performance data revealed a time stress main effect for arithmetic accuracy. The interaction between time stress and decision load was also significant for shooting accuracy and arithmetic accuracy. Results from analyses of the ERSP data revealed that peak theta power differed as a function of time stress and peak alpha power differed as a function of task load and decision load. Overall, the results suggest that time stress had the most profound and widespread effects on workload perceptions and performance. Cortical responses exhibited different oscillatory patterns of communication at different frequencies and topographic regions in response to the different task demand factors. C1 USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Kerick, SE (reprint author), USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 4 TC 0 Z9 0 U1 0 U2 2 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 359 EP + DI 10.1142/9789812772572_0046 PG 5 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200046 ER PT B AU Mullins, L Patton, D Garrett, L AF Mullins, Linda Patton, Debbie Garrett, Lamar BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Performance measures for dismounted warrior encapsulation effects SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary AB Research regarding the effects of encapsulation on soldier performance is critical for achieving effective mission performance as well as the survivability capabilities of dismounted soldiers of the Future Force. Soldier encapsulation is defined as enclosing the soldier's body in such a manner that all skin is protected from exposure to the elements of the battlefield. The objective of this research is to identify the effects of encapsulation on mission performance and to develop methods for further research on encapsulation effects of Future Force soldier systems. This research investigated the effects of three equipment configurations (baseline and two encapsulation configurations) on soldier performance during three mission related scenarios. Encapsulation effects on soldier's cognitive functioning and stress perceptions are discussed here. The characterization of cognitive performance and psychological state during military operations affords better understanding of human performance capabilities and opportunities to find predictors of future performance effectiveness. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Mullins, L (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 363 EP + DI 10.1142/9789812772572_0047 PG 8 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200047 ER PT B AU Kamimori, GH Johnson, D Belenky, G McLellan, T Bell, D AF Kamimori, G. H. Johnson, D. Belenky, G. McLellan, T. Bell, D. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Caffeinated gum maintains vigilance, marksmanship, and PVT performance during a 55 hour field trial SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID SLEEP-DEPRIVATION; COGNITIVE PERFORMANCE; ALERTNESS; MOOD; WAKEFULNESS; STRESS AB This study was designed to evaluate the effectiveness of caffeine gum in maintaining performance on a variety of military tasks during a 55 hr field training exercise with restricted sleep. A secondary goal was to correlate performance on a hand held computerized Psychomotor Vigilance Test (PVT) with actual performance of a field task. Thirty Canadian soldiers volunteered to participate in this study and were divided into 4 sections. After receiving 3 hours of sleep during the first night, they were awake for 30 hours. Two of the four sections received caffeine gum (CAF) and the other two groups a placebo gum (PLA). On the evening of Day 2 and morning of Day 3 subjects in CAF received 100 mg @ 2145 (Day 2), 200 mg @ 2345 (Day 2), 100 mg @ 0145 (Day 3), and 200 mg @ 0345 (Day 3). The placebo group always received the placebo gum. There were two test blocks from 2200-0200 (early night) and from 0200-0600 (late night). In each of the two test blocks subjects completed a live fire marksmanship/vigilance task and an Urban Operations Vigilance Task (UOVT). The PVT was administered prior to and after marksmanship and the UOVT. Performance on all of the field tasks significantly declined during the second night of the exercise with placebo. In contrast, subjects who received the caffeine gum maintained their performance on the marksmanship task and in the FIBUA task. These results demonstrate the potential utility of caffeine as a fatigue countermeasure in the operational environment. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Kamimori, GH (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 16 TC 0 Z9 0 U1 0 U2 2 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 370 EP + DI 10.1142/9789812772572_0048 PG 8 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200048 ER PT B AU Schiffman, JM Bensel, CK Hasselquist, L Norton, K Piscitelle, L AF Schiffman, Jeffrey M. Bensel, Carolyn K. Hasselquist, Leif Norton, Karen Piscitelle, Louis BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI The effects of soldiers' loads on postural sway SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID STABILITY; CARRIAGE AB The purpose of the study was to investigate the effects of load weight and load configurations upon postural sway of Soldiers. Measuring postural sway may complement analyses of walking with loads, allowing for quick and efficient determination of how load carriage gear will impact the Soldier. Fourteen Army enlisted men participated in the study. Postural sway was measured while participants stood on a force platform. Soldiers were tested under four load weight configurations comprised of Army clothing and equipment: unloaded (6 kg), fighting load (16 kg), and march load (40 kg) with rucksack weight located close to the body and high in the pack, and a second march load (40 kg) with rucksack weight located far from the body and low in the pack. With an increase in weight, center of pressure excursions increased and Soldiers had to exert more control of the load to maintain balance. As the pack load weight position moved from high and close to low and away from the body, center of pressure excursions continued to increase and the rucksack became quite difficult for a load carrier to control precisely. This study demonstrated that an increase in load weight and a change in rucksack weight position changes both the individual's postural sway and the structure of the sway. C1 USA, Natick Soldier Ctr, Natick, MA 01760 USA. RP Schiffman, JM (reprint author), USA, Natick Soldier Ctr, Natick, MA 01760 USA. NR 21 TC 0 Z9 0 U1 1 U2 2 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 377 EP + DI 10.1142/9789812772572_0049 PG 9 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200049 ER PT B AU Senecal, AG Senecal, KJ Magnone, JP Pivarnik, PE AF Senecal, A. G. Senecal, K. J. Magnone, J. P. Pivarnik, P. E. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Development of nanofibrous membranes towards biological sensing SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID ESCHERICHIA-COLI; SALMONELLA; SAMPLES; FIBERS; WATER; MILK; FOOD; PCR AB A novel research approach was investigated to improve sample preparation for complex food matrices, generating high surface area nanofibrous membranes with covalently attached molecular recognition elements (MREs, e.g. antibodies, peptides/DNA) for the selective binding/capture of target biological agents using the electrospinning fabrication technique. Two types of electrospun capture membranes were fabricated containing either carboxyl (COOH) or amine (NHz) functional groups for covalent attachment of antibodies. The carboxylated electrospun polymer used in this study was polyvinyl chloride formulated to be 1.8% carboxylated. The amine functional membrane was made by co-electrospinning two polymers, water-soluble polyamine and water insoluble polyurethane. Linking of molecular recognition groups, antibodies, to the carboxylated PVC was performed using established crosslinking chemistries. Antigen/antibody experiments were performed on the electrospun membranes containing primary antibodies covalently attached on the membranes with different secondary antibody specificity. Results showed that electropun membranes, treated with the secondary antibody, reacted only with its complement as indicated with a chemi-luminescent signal versus those membranes having bound a different, or non-complementary primary antibody. Toxin studies with Staphylococcal enterotoxin B (SEB) were conducted using avidin/biotin chemistries on the electrospun membranes. Experiments were performed using a sandwich assay (avidin-SEB biotinylated antibody -SEB toxin- SEB antibody-HRP). Results showed that 1ng-100ng /ml concentration of toxin were detected in a nonoptimized experiment. C1 USA, RDECOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Senecal, AG (reprint author), USA, RDECOM, Natick Soldier Ctr, Natick, MA 01760 USA. RI Senecal, Kris/F-3000-2013 NR 17 TC 1 Z9 1 U1 1 U2 3 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 387 EP + DI 10.1142/9789812772572_0050 PG 8 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200050 ER PT B AU Dubick, MA Cameron, DG Sondeen, JL Majumdar, APN AF Dubick, Michael A. Cameron, David G. Sondeen, Jill L. Majumdar, Adhip P. N. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Hypotensive resuscitation of casualties in the far-forward combat environment: Effects of select crystalloids and colloids on signal transduction mediators in a swine model of severe hemorrhage SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; RENAL ISCHEMIA-REPERFUSION; INDUCED LUNG INJURY; OXIDATIVE STRESS; MESENTERIC LYMPH; GASTRIC-MUCOSA; IN-VITRO; SHOCK; INDUCTION AB Despite years of treating trauma patients, the optimal fluid and strategy for the resuscitation of hemorrhagic hypovolemia remains unknown. Hypotensive resuscitation is a rational approach for the military due to logistic constraints to treat casualties on the battlefield, and to minimize rebleeding from penetrating injuries. In the present study anesthetized, splenectomized and instrumented 40 kg swine (n=8-10/gp) were subjected to a controlled hemorrhage of 20 ml/kg over about 5 min that duplicated the blood loss profile of an uncontrolled hemorrhage. After 30 min, fluid resuscitation was initiated along with a second hemorrhage of 8 ml/kg. Fluid infusion was controlled to return systolic blood pressure to 80 mmHg, as necessary throughout the experiment. Hemodynamic and metabolic variables were monitored continuously and blood samples were drawn at baseline (BL), and at select times throughout the 3.5 hr experimental period or until death. Tissues were collected at necropsy, homogenized and the content of total and phosphorylated EGF-R was determined by Western blot analysis. Evidence for lipid peroxidation or free radical generation was also determined. Hemorrhage reduced MAP to about 36 mmHg and lowered cardiac output (CO) to 36% of BL in all groups. CO improved the most in the Hextend group. PolyHeme infusion resulted in the highest blood pressure and lowest CO in surviving animals compared with the other fluids, but differences were not statistically significant among groups. Base deficit and plasma lactate increased during the 3.5 hr experiment in all groups. In the PolyHeme and Hextend groups, duodenal EGF-R levels were 73% and 33%, respectively, of the levels observed in LR treated pigs. EGF-R activation was about 50% higher in Hextend treated pigs compared to the LR and PolyHeme groups. As a result, about 60% of the EGF-R in duodenum from PolyHeme treated pigs was in the activated form compared to 37% and 18% in the Hextend and LR groups, respectively. In summary, all fluids improved hemodynamics and resulted in similar short term survival in this model of severe hemorrhage. Biochemical analyses suggest that resuscitation fluids can have different effects on signal transduction mediators that should be considered in designing the optimal fluid for long term improved outcome. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Dubick, MA (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 34 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 394 EP + DI 10.1142/9789812772572_0051 PG 8 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200051 ER PT B AU Gordon, RK Haigh, JR Garcia, GE Feaster, SR Doctor, BP Riel, MA Lefkowitz, LJ Lenz, DE Aisen, PS Smart, W AF Gordon, Richard K. Haigh, Julian R. Garcia, Gregory E. Feaster, Shawn R. Doctor, Bhupendra P. Riel, Michael A. Lefkowitz, Lee J. Lenz, David E. Aisen, Paul S. Smart, Wilson BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Whole blood robotic cholinesterase assay for organophosphate exposure - Testing soldiers, first responders, and civilians in the field and laboratory SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID HUPERZINE; DISEASE AB The Walter Reed Army Institute of Research Whole Blood (WRAIR WB, U.S. Patent #6,746,850, 2004) cholinesterase assay (a) rapidly determines the activity of both ACNE and BChE in unprocessed (uncentrifuged) whole blood, (b) uses a minimally invasive blood sampling technique (e.g., blood from a finger prick), and (c) is semi-automated for high-throughput using the Biomek 2000 robotic system (see Figure 1). The method measures ChE activity in whole blood in the presence of the chromophore 4, 4' dithidiopyridine (DTP) and three thiocholine substrates, from which the individual ACNE and BChE activities are calculated. Due to the documented use of OPs by terrorists and in warfare around the globe, Federal, State, and local authorities need a reliable, fast, inexpensive, and standard method for confirming such an assault in order to initiate appropriate containment, decontamination, and treatment measures. Thus, the WRAIR whole blood cholinesterase assay, with its high-throughput robotic capability, is ideal for prescreening military personnel for ChE activities that might preclude their deployment to areas of potential CWA exposure. This assay fulfills the requirement for rapid and reliable monitoring of OP exposure in military and civilian populations. C1 Walter Reed Army Inst Res, Div Biochem, Dept Biochem Pharmacol, Silver Spring, MD 20910 USA. RP Gordon, RK (reprint author), Walter Reed Army Inst Res, Div Biochem, Dept Biochem Pharmacol, Silver Spring, MD 20910 USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 401 EP + DI 10.1142/9789812772572_0052 PG 9 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200052 ER PT B AU Singer, DE Hird, L Bulken-Hoover, J Foglia, G Royster, RD Malia, JA Calero, EK Sateren, W Robb, ML Birx, DL Michael, NL AF Singer, Darrell E. Hird, Linda Bulken-Hoover, Jamie Foglia, Ginamarie Royster, R. Donald Malia, Jennifer A. Calero, Eva K. Sateren, Warren Robb, Merlin L. Birx, Deborah L. Michael, Nelson L. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Prospective and retrospective testing of high prevalence HIV-1 serum and blood using rapid and conventional technology SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID SIMIAN IMMUNODEFICIENCY VIRUS; INFECTION; ANTIBODIES; UGANDA AB We have conducted studies with existing rapid HIV-1 serology technology for applicability in military operations. Studies on fresh and frozen serum and differing HIV subtypes have been conducted in both the research and field environments. Testing has been compared to reference technology for calculation of operating characteristics. Conclusion: Rapid HIV-1 testing technology is an evolving field subject to market demands. Several tests exist that support warfighter use in the field. However, these tests should still be utilized in the context of the medical risk decision making process. C1 Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. RP Singer, DE (reprint author), Walter Reed Army Inst Res, Div Retrovirol, 1600 E Gude Dr, Rockville, MD 20850 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 409 EP 414 DI 10.1142/9789812772572_0053 PG 6 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200053 ER PT B AU Oleng, N Reifman, J Berglund, L Hoyt, R AF Oleng, Nicholas Reifman, Jaques Berglund, Larry Hoyt, Reed BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Alternative approaches to improve physiological predictions SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID MODELS; HEAT AB Recent advancements in technology have resulted in new biosensors and information processing capabilities that permit on-line, real-time measurement of physiological variables. This has, in turn, given rise to the possibility of developing soldier-specific, data-driven predictive models for assessing physiological status in the battlefield. This paper explores how the accuracy of a predictive model based on first principles physiology can be enhanced by data-driven "black box" techniques of modeling and predicting human physiological variables. Such hybrid techniques are employed here in the prediction of core temperature. Preliminary results show that the mean square error of prediction can be reduced by up to fifty percent for prediction horizons of up to 30 minutes. C1 USA, Med Res & Mat Command, Bioinformat Cell Telemed & Adv Technol Res Ctr, Frederick, MD 21701 USA. RP Oleng, N (reprint author), USA, Med Res & Mat Command, Bioinformat Cell Telemed & Adv Technol Res Ctr, Frederick, MD 21701 USA. NR 14 TC 0 Z9 0 U1 0 U2 2 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 415 EP + DI 10.1142/9789812772572_0054 PG 9 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200054 ER PT B AU Sekowski, JW Orehek, MA Bucher, J Vahey, M Nau, M Horsmon, MS Menking, D Whalley, C Benton, B Mioduszewski, R Thomson, S Valdes, JJ AF Sekowski, J. W. Orehek, M. A. Bucher, J. Vahey, M. Nau, M. Horsmon, M. S. Menking, D. Whalley, C. Benton, B. Mioduszewski, R. Thomson, S. Valdes, J. J. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Low-level inhalation exposure to chemical nerve agent vapor induces expression of neuronal apoptosis and regeneration genes SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID MODEL AB For over a decade following the end of the first Gulf War in 1991, there has been increasing concern to understand the immediate and persistent effects of sub-acute and low-level exposures to chemical warfare agents. Although low-level exposures may not cause obvious pathology at the time of exposure, they may cause molecular-level alterations in the brain and other vital organ systems. The work described in this manuscript was designed to measure the gene and protein expression alterations in the brains of male and female rats exposed to sub- and peri-miotic levels of the aerosolized nerve agents satin (GB) and cyclosarin (GF). Gene expression was assessed using DNA microarray analysis. The microarray data were verified by real-time RT-PCR and Western immunoblotting where possible. The overall aim of this project is to measure and characterize the gene and protein level alterations that may reveal near term, operational risks as well as changes that may predispose an individual to injury or disease later in life. To date, our results indicate that: 1) low-level inhalation exposure to GB and GF results in the differential expression of a number of neuronal genes, including a group that participate in cellular processes critical to neurological injury and regeneration and 2) there are significant gender-associated differences in the level and type of gene expression response. C1 USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Sekowski, JW (reprint author), USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, AMSSB RRT BM,5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 425 EP + DI 10.1142/9789812772572_0055 PG 6 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200055 ER PT B AU Hammamieh, R Jett, M AF Hammamieh, Rasha Jett, Marti BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Global gene expression analysis to unambiguously identify host gene responses characteristic of exposure to biothreat agents SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID IDENTIFICATION AB We are studying the complex interaction between various biological pathogens and the host to understand the basis of infection or biothreat-induced diseases and to identify host defense strategies and the mechanisms by which they are regulated. Although gene response profiles show unique signatures quite rapidly after exposure, they also have the potential to reveal phases of progression of illness to a) provide stage-specific diagnosis and b) identification of potential molecular targets for stage-appropriate therapeutic interventions for intractable illness induced by unconventional pathogenic agents. We have used a library of 20,000 human cDNA (10,000 are known genes) to construct customized microarray chips used in these studies. We determined gene expression in human peripheral blood mononuclear cells (PBMC) in response to 15 pathogens at different time points in vitro (3-5 replicates). This provided a framework for us to then utilize responses in animal models that closely imitate the illness as it occurs in humans. For those studies, PBMC or whole blood were collected at various time points post exposure to track the primary, secondary and subsequent gene responses elicited by the pathogenic agents. The massive amounts of data are overwhelming but provide an incredibly rich source for both diagnostic and therapeutic approaches. We have identified host gene expression patterns that can discriminate exposure to various biological threat agents. Each of these gene patterns regulated by a specific agent reveals the cascade of events that occurs after the host encounters a pathogenic agent. Even though these pathogens initially cause similar symptoms, such as malaise, fever, headache, and cough, the course of illness induced by each of them differs in time frame of illness patterns. Using these signature gene profiles to assess possible exposure to pathogenic agents or to differentiate them from non lethal illnesses when the classical identification of a pathogen is not conclusive may fill a gap in the arsenal of diagnostic tools. Rapid detection, before the symptoms appear or even at various stages of illness, offers the opportunity to initiate appropriate treatment. Furthermore, this technique may provide the means to identify new therapeutic approaches to ameliorate the devastating results of these pathogens. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Hammamieh, R (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 7 TC 0 Z9 0 U1 0 U2 2 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 430 EP + DI 10.1142/9789812772572_0056 PG 9 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200056 ER PT B AU O'Connell, KP Anderson, PE Horsmon, MS Valdes, JJ AF O'Connell, Kevin P. Anderson, Patricia E. Horsmon, Michael S. Valdes, James J. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Native and engineered simulants for DNA virus threat agents SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID BACULOVIRUS AB Bacteriophage MS2 is currently the only virus widely accepted for low-level containment or field release in the development of BW detection methods. However, MS2 does not resemble orthopoxviruses, a group of viruses of particular concern. We describe here assays for the detection of baculoviruses as an alternative to MS2. C1 USA, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21010 USA. RP O'Connell, KP (reprint author), USA, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD 21010 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 446 EP + DI 10.1142/9789812772572_0058 PG 6 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200058 ER PT B AU Zukas, W Sennett, M Welsh, E Rodriguez, A Ziegler, D Touchet, P AF Zukas, Walter Sennett, Michael Welsh, Elizabeth Rodriguez, Axel Ziegler, David Touchet, Paul BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Permeation behavior and physical properties of natural rubber nanocomposites SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID LAYERED SILICATE NANOCOMPOSITES AB Nanocomposites made by adding nanoparticle reinforcement to polymers have been demonstrated to have significantly enhanced properties at relatively low levels of added reinforcement. The observed properties have in some cases been attributed to the shape of the reinforcing particle. Nanoparticle additives with a variety of particle morphologies and compositions have become commercially available in recent years. A study was carried out to examine the effects of varying nanoparticle morphology and composition on the mechanical and barrier properties of polymer nanocomposites made with natural rubber (NR). NR compounds were prepared containing different nanoparticles including montmorillonite layered silicate (MLS) clay, exfoliated graphite nanoparticles (EGN), carbon nanotubes (CNT) and conventional carbon black (CB). The cure behavior and mechanical properties of the prepared nanocomposites were investigated. Barrier property testing included permeation of selected organic compounds utilizing a recently developed fully flooded surface method. The relationships between these properties and nanoparticle composition and morphology are presented. C1 USA, Res Dev & Engn Command, Natick Soldier Ctr, Natick, MA 01760 USA. RP Zukas, W (reprint author), USA, Res Dev & Engn Command, Natick Soldier Ctr, Natick, MA 01760 USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 467 EP + DI 10.1142/9789812772572_0061 PG 7 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200061 ER PT B AU Kumar, A Dwarakanath, S Bruno, JG Stephenson, LD AF Kumar, Ashok Dwarakanath, Sulatha Bruno, John G. Stephenson, L. D. BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Receptor-conjugated nanoparticles to detect biological warfare agents SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary DE antibody; fluorescence; nanoparticle; quantum dot; wavelength shift ID PROSTATE-SPECIFIC ANTIGEN; FLUORESCENCE; ASSAY AB Recent research has examined the feasibility of detecting biological warfare agents by conjugating their antibodies (receptors) with taggant nanoparticles (also known as "quantum dots"), which subsequently fluoresce upon excitation, when they are bound to a specific biowarfare agent, or its simulant. Furthermore, when they react with their target bacteria, optically excited nanoparticle-receptor conjugates generate spectra in which the intensities of primary emission peaks are diminished, while the secondary emission peaks increase in intensities, i.e., energy is transferred from major peaks to minor peaks. These optical emission spectral signatures, with emission wavelength shifts of 140 nn in some cases, strongly suggest the possibility of homogeneous (one step) assays, leading to positive detection of bacterial agents, without wash steps using nanoparticle-receptor conjugates. C1 USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Kumar, A (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. NR 5 TC 0 Z9 0 U1 1 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 478 EP + DI 10.1142/9789812772572_0063 PG 8 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200063 ER PT B AU Goldberg, A AF Goldberg, Arnold BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Laboratory and field performance of a megapixel QWIP focal plane array SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary AB The results of laboratory and field testing of a new large format infrared focal plane array based on quantum well infrared photodetector technology are presented. The array used had 1024X1024 pixels and is available commercially. from QWIP Technologies, Inc. The laboratory test results show that this array had high system-level performance. Imagery of military targets at ranges from 500 m to 5 km was acquired in the field with a sensor using this array. The results of the performance in the field are compared to that predicted by computer models and the performance of the large format QWIP FPA was evaluated in terms of the capabilities of a notional 3rd generation FLIR system. C1 USA, Res Lab, EO Photon Div, Adelphi, MD 20783 USA. RP Goldberg, A (reprint author), USA, Res Lab, EO Photon Div, Adelphi, MD 20783 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 493 EP + DI 10.1142/9789812772572_0065 PG 9 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200065 ER PT B AU Zhou, WM Weiss, S Fazi, C AF Zhou, Weimin Weiss, Steven Fazi, Christian BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Developing RF-photonics components for the army's Future Combat Systems SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID OSCILLATOR AB The U.S. Army's Future Combat Systems are designed to support the future force with three integrated transformation phases: Concept and Technology Development, Systems Design, Demonstration and Production. The Concept and Technology Developments phase is creating new challenges and opportunities for radio frequency and microwave applications in global positioning, navigation, timing, communications, improved radar target detection, and new forms of combat identification. The merging of photonics and microwave electronics may revolutionize the traditional microwave technologies and explore many new technology fields. This merging has led to several significant developments such as higher frequency of operation and the capability to change frequency faster with greater agility, the ability to use larger bandwidths at higher frequencies, to improve the stability low phase noise oscillators (useful for low Doppler Radar target detection) and for novel methods of phase array antenna steering. In this paper we review two important system milestones by merging optoelectronics with microwaves, the injection locked dual opto-electronic-oscillator (OEO) and the optical controlled microwave phased array antenna. C1 USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Zhou, WM (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 501 EP + DI 10.1142/9789812772572_0066 PG 8 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200066 ER PT B AU Temmen, M Diffey, W Ashley, P AF Temmen, Mark Diffey, William Ashley, Paul BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Integrated optical transceiver for inertial sensors using polymer waveguide technology SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary AB The application of polymer technology in integrated optical components provides a method of increasing the level of integration with the real potential of reducing unit cost. This paper describes the application of this technology in an integrated optical transceiver unit designed for an inertial sensor system, or more specifically, for an interferometric fiber optic gyroscope (IFOG) system. The design and fabrication of the optical polymer waveguide component and its integration with other discreet components to construct a transceiver is described. C1 USA, RDECOM, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Temmen, M (reprint author), USA, RDECOM, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. NR 4 TC 0 Z9 0 U1 1 U2 3 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 508 EP + DI 10.1142/9789812772572_0067 PG 7 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200067 ER PT B AU von der Lippe, CM Keeler, GA Serkland, DK Geib, KM Peake, GM Mar, A Liu, JJ AF von der Lippe, Christian M. Keeler, G. A. Serkland, D. K. Geib, K. M. Peake, G. M. Mar, A. Liu, J. Jiang BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Photonics technology development for optical fuzing SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID LASER AB This paper describes the photonic component development, which exploits pioneering work and unique expertise at Sandia National Laboratories, ARDEC and the Army Research Laboratory by combining key optoelectronic technologies to design and demonstrate components for this fuzing application. The technologies under investigation for the optical fuze design covered in this paper are vertical cavity surface emitting lasers (VECSELs), integrated resonant cavity photodetectors (RCPD), and diffractive micro-optics. The culmination of this work will be low cost, robust, fully integrated, g-hardened components designed suitable for proximity fuzing applications. The use of advanced photonic components will enable replacement of costly assemblies that employ discrete lasers, photodetectors, and bulk optics. The integrated devices will be mass produced and impart huge savings for a variety of Army applications. C1 USA, Armament Res Dev & Engn Ctr, AMSRD AAR AEP FA, Adelphi, MD 20783 USA. RP von der Lippe, CM (reprint author), USA, Armament Res Dev & Engn Ctr, AMSRD AAR AEP FA, Adelphi, MD 20783 USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 522 EP + DI 10.1142/9789812772572_0069 PG 6 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200069 ER PT B AU Morefield, SW McInerney, MK Hock, VF Marshall, OS Malone, PG Weiss, CA Sanchez, J AF Morefield, Sean W. McInerney, Michael K. Hock, Vincent F. Marshall, Orange S., Jr. Malone, Philip G. Weiss, Charles A., Jr. Sanchez, Joan BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI Rapid soil stabilization and strengthening using electrokinetic techniques SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary AB The Army has a requirement to develop methods of strengthening soil to support rapid runway and roadway construction. A study was undertaken on the use of DC current applied to soil to form cementing phases in the soil. Preliminary work was on the use of zinc, aluminum, and iron in a variety of granular materials. Metal ions primarily form soft metal hydroxide gels that produce no immediate soil strengthening. Passing current through soil mixed with an alkali-reactive silicate produces rapid hardening with strength to 2,000 psi. C1 USA, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Morefield, SW (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 529 EP + DI 10.1142/9789812772572_0070 PG 6 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200070 ER PT B AU Haines, PA Grove, DJ Sun, WY Hsu, WR AF Haines, Patrick A. Grove, David J. Sun, Wen-Yih Hsu, Wu-Ron BE Parmentola, JA Rajendran, AM Bryzik, W Walker, BJ McCaulehy, JW Reifman, J Nasrabadi, NM TI High resolution results and scalability of numerical modeling of wind flow at White Sands Missile Range SO Transformational Science and Technology for the Current and Future Force SE SELECTED TOPICS IN ELECTRONICS AND SYSTEMS LA English DT Proceedings Paper CT 24th Army Science Conference CY NOV 29-DEC 02, 2004 CL Orlando, FL SP Army Acquist, Logist, & Technol, Assistant Secretary ID SURROUNDING AREA; SIMULATION; VORTICES; TAIWAN; SPLIT AB The NTU/Purdue nonhydrostatic numerical model has been developed over the last 6 years to predict atmospheric motions and conditions for both the mesoscale (200 m to 200 km) and large scale turbulence scale (20 m to 200 m). It is a fully explicit, compressible three-dimensional code and has compared quite to a wide variety of known analytical solution or observed situations including the Boulder Wind Storm, nonhydrostatic and hydrostatic mountain waves for flow over an isolated mountain and a 2-dimensional mountain barrier, and buoyant bubble. The model has application to FCS requirements for providing fine scale weather information for small unit operations in near real-time. It will enable us to study and better understand the problems of diagnosing and predicting atmospheric flow and conditions in real terrain. It is also designed and being applied to simulate larger turbulent eddies particularly in stable atmospheric boundary layers which are important for night operations. Large scale turbulence is a key to accounting for small scale turbulence that affects electromagnetic and acoustic propagation and governs local diffusion. This paper considers both idealized and real terrain simulations in which the model was applied at high resolution (Delta x, Delta y of 500 m to 1 km) to the Organ, San Andres and Franklin Mountains region on and near the White Sands Missile Range (WSMR) in New Mexico. We used DTED level 1 terrain data (3 arc second resolution) to generate the model's terrain fields. C1 USA, Res Lab, Computat & Informat Sci Directorate, White Sands Missile Range, NM 88002 USA. RP Haines, PA (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, White Sands Missile Range, NM 88002 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-270-201-2 J9 SEL TOP ELECTR SYST PY 2006 VL 42 BP 541 EP + DI 10.1142/9789812772572_0072 PG 9 WC Engineering, Multidisciplinary; Multidisciplinary Sciences SC Engineering; Science & Technology - Other Topics GA BFR63 UT WOS:000244038200072 ER PT B AU Chang, DJ AF Chang, David J. BE Wong, SC Hau, TD Wang, JJ Chau, KW Ho, HW TI REVIEW OF FLEXIBILITY IN TRANSPORTATION SYSTEMS SO TRANSPORTATION STUDIES: SUSTAINABLE TRANSPORTATION, PROCEEDINGS OF THE 11TH INTERNATIONAL CONFERENCE OF HONG KONG SOCIETY FOR TRANSPORTATION STUDIES LA English DT Proceedings Paper CT 11th International Conference of the Hong-Kong-Society-for-Transportation-Studies CY DEC 09-11, 2006 CL Hong Kong, PEOPLES R CHINA SP Hong Kong Soc Transportat Studies, Univ Hong Kong, Dept Civil Engn, Univ Hong Kong, Sch Econom & Finance, Univ Hong Kong, Sch Geog, Univ Hong Kong, Res Grp Sustainable Cities ID NETWORK; CAPACITY; FREIGHT AB This paper reviews current research on flexibility of transportation systems. It will discuss flexibility as a general problem and provide examples of previous measures and approaches. Fundamentally flexibility concepts provide measures of the ability of a system to maintain satisfactory and sustainable performance when uncontrollable and often unforeseen events occur. Such events include natural disasters, deliberate damage from war or terrorism, changes in the economy or society, among others. Thus they provide an important input for planning, design, and operation of transport systems, so that the system can adapt to the changed conditions. C1 US Mil Acad, D EECS, West Point, NY 10996 USA. RP Chang, DJ (reprint author), US Mil Acad, D EECS, Bldg 601, West Point, NY 10996 USA. NR 34 TC 0 Z9 0 U1 0 U2 3 PU HONG KONG UNIVERSITY SCIENCE &TECHNOLOGY PI KOWLOON PA CLEAR WATER BAY, KOWLOON, HONG KONG BN 978-988-98847-0-3 PY 2006 BP 469 EP 477 PG 9 WC Transportation Science & Technology SC Transportation GA BIO18 UT WOS:000261328800044 ER PT B AU Lahart, MJ Fazi, C Kohlberg, I AF Lahart, M. J. Fazi, C. Kohlberg, I. GP IEEE TI Complex modes of a dielectric covered ground plane SO ULTRAWIDEBAND AND ULTRASHORT IMPULSE SIGNALS, PROCEEDINGS LA English DT Proceedings Paper CT 3rd International Conference on Ultrawideband and Ultrashort Impulse Signals CY SEP 18-22, 2006 CL Sevastopol Natl Tech Univ, Sevastopol, UKRAINE HO Sevastopol Natl Tech Univ DE microstrip; propagation modes ID LINES AB Sources and related components to support High Power Electromagnetic (HPEM) ultra-wideband systems are of growing importance. The ultra-wideband domain is characterized by a bandwidth ratio, br = (f(high)/f(low)) > 10 with a nominal center frequency in the GHz range. Shielded microstrips and coplanar waveguides may find increasing application for developing advanced ultra-wideband systems. Dielectric covered ground planes are often part of microstrip or coplanar waveguides and properties of their propagation modes need to be better understood. Over the years, several different techniques and theories have been used to analyze the propagation modes of dielectrics covered planes. In this paper, expressions for the transverse wave numbers within the dielectric and above it are derived for two types of modes, denoted as transverse magnetic and transverse electric (TM and TE). In contrast to earlier work our fields are transverse to the direction normal to the dielectric interface, not to the direction of propagation. In addition to modes with real transverse wave numbers, modes with complex transverse wave numbers are shown to occur in conjugate pairs whose members can be combined into patterns with sinusoidal variation in the direction normal to the surface of the dielectric. Some of the results are presented in tables in which the propagation constants, computed from the wave equation, are also given. C1 [Lahart, M. J.; Fazi, C.] USA, Res Lab, Adelphi, MD 20783 USA. [Kohlberg, I.] Kohlberg Assoc Inc, Alexandria, VA 22304 USA. RP Lahart, MJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM lahart@arl.army.mil; ikohlber@ida.org NR 8 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 1-4244-0513-0 PY 2006 BP 272 EP + DI 10.1109/UWBUS.2006.307227 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BFN32 UT WOS:000243250000078 ER PT S AU Reiff, C Scanlon, M Noble, J AF Reiff, C. Scanlon, M. Noble, J. BE Carapezza, EM TI Acoustic detection and localization from a tethered aerostat during the NATO TG-53 test - art. no. 623104 SO Unattended Ground , Sea, and Air Sensor Technologies and Applications VIII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications VIII CY APR 17-20, 2006 CL Kissimmee, FL DE acoustic array; detection; localization; aerostat AB Acoustic sensors mounted to a tethered aerostat detect and localize transient signals from mortars, artillery, C-4, propane cannon, and small arms fire. Sig ificant enhancements to soldier lethality and survivability can be gained when using the aerostat array to detect, localize, and cue an aerial imager to a weapon's launch site, or use the aerostat's instantaneous position and orientation to calculate a vector solution to the ground coordinates of the launch site for threat neutralization. The prototype aerostat-mounted array was tested at Yuma Proving Grounds (YPG) as part of the NATO TG-53 signature collection exercise. Acoustic wave form data was collected simultaneously with aerostat and ground-based sensor array for comparing wind noise, signal to noise related parameters, and atmospheric effects on propagation to an elevated array. A test description and summary of localization accuracy will be presented for various altitudes, ranges to target, and under differing meteorological conditions. C1 USA, Res Lab, AMSRD, ARL,SE,SA, Adelphi, MD 20783 USA. RP Reiff, C (reprint author), USA, Res Lab, AMSRD, ARL,SE,SA, Adelphi, MD 20783 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6287-X J9 P SOC PHOTO-OPT INS PY 2006 VL 6231 BP 23104 EP 23104 AR 623104 DI 10.1117/12.669710 PG 12 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BEU84 UT WOS:000239560800002 ER PT S AU Damarla, TR Mirelli, V AF Damarla, T. Raju Mirelli, V. BE Carapezza, EM TI Distributed acoustic sensor data processing for target classification - art. no. 623105 SO Unattended Ground , Sea, and Air Sensor Technologies and Applications VIII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications VIII CY APR 17-20, 2006 CL Kissimmee, FL DE target classification; distributed processing; Bayesian classifier; multivariate Gaussian classifier AB The Acoustics Signal Processing Branch at the U.S. Army Research Laboratory has been investigating tracking and classification of military and civilian vehicles using acoustic sensors. Currently the target signals are modeled as a sum of harmonics and then they are classified using multivariate Gaussian classifier at each individual node. When multiple targets are present in the scene overall classification of the targets deteriorates as the signals from several targets are mixed together and determinations of individual target harmonics become difficult. This is true particularly for civilian vehicles. In order to improve the overall probability of correct classification a distributed classifier will be implemented. In a distributed processing each sensor node would broadcast the classification information, that is, probability of detection of various targets, to all the sensors within its vicinity. At each sensor node a distributed Bayesian classifier is used to determine the overall classification of each target. The distributed processing is robust to failures in sensor nodes unlike the centralized processing. Although the technique is known [9, 10], it had been tested using only simulated data. In this paper we present the results of the algorithm on real data that was collected using several acoustic sensors using a mixture of military and civilian vehicles. This would identify how well the distributed processing works or its limitations in classifying multiple targets using acoustic data. C1 USA, Res Lab, Acoust Signal Proc Branch, Adelphi, MD 20783 USA. RP Damarla, TR (reprint author), USA, Res Lab, Acoust Signal Proc Branch, Adelphi, MD 20783 USA. NR 10 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6287-X J9 P SOC PHOTO-OPT INS PY 2006 VL 6231 BP 23105 EP 23105 AR 623105 DI 10.1117/12.664585 PG 6 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BEU84 UT WOS:000239560800003 ER PT S AU Lacombe, J Peck, L Anderson, T Fisk, D AF Lacombe, James Peck, Lindamae Anderson, Thomas Fisk, David BE Carapezza, EM TI Seismic detection algorithm and sensor deployment recommendations for perimeter security - art. no. 623109 SO Unattended Ground , Sea, and Air Sensor Technologies and Applications VIII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications VIII CY APR 17-20, 2006 CL Kissimmee, FL DE force protection; unattended ground sensors; seismic; walker detection AB Field studies were conducted in 2005 in Yuma, Arizona at the Yuma Proving Grounds (YPG) to document seismic signatures of walking humans. Walker-generated vertical ground vibrations were recorded using standard omnidirectional 4.5 Hz peak-resonance geophones. Walker position and speed were measured using portable GPS equipment. Collected seismic data were processed and hypothetical sensor performance predictions were made using an algorithm developed for the detection and classification of a walking intruder. Sample results for the Yuma study are presented in the form of sensor detection/classification vs. range plots, and color-coded animations of seismic sensor alarm annunciations during walking, intruder tests. A perimeter intrusion scenario for a Forward Operating Base is defined that involves a walker approaching a sensor picket-line along a path exactly halfway between two adjacent sensors. This is considered a conservative representation of the perimeter intrusion problem. Summary plots derived from a binomial probability based analysis define intruder detection probabilities for different sensor spacings. For a 215 lb intruder walking in the Yuma test environment, a 90% probability of at least two walker-classified sensor detections is achieved at a sensor spacing of 140 m. Preliminary investigations show the intruder classification component of the discussed detection/classification algorithm to perform well at rejecting signals associated with a nearby idling vehicle and normal background noise. C1 USA, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03775 USA. RP Lacombe, J (reprint author), USA, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03775 USA. NR 8 TC 4 Z9 4 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6287-X J9 P SOC PHOTO-OPT INS PY 2006 VL 6231 BP 23109 EP 23109 AR 623109 DI 10.1117/12.668766 PG 10 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BEU84 UT WOS:000239560800007 ER PT S AU Zong, L Houser, J Damarla, TR AF Zong, Lei Houser, Jeff Damarla, T. Raju BE Carapezza, EM TI Multi-modal unattended ground sensor (MMUGS) - art. no. 623118 SO Unattended Ground , Sea, and Air Sensor Technologies and Applications VIII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications VIII CY APR 17-20, 2006 CL Kissimmee, FL DE multi-modal; miniature sensor; personnel detection; low-power; sensor network AB The U.S. Army Research Laboratory has developed a real-time multi-modal sensor for the purpose of personnel detection in urban terrain. Possible system usage includes force protection and sniper early warning. The sensor system includes a-network of MMUGS sensors, a third-party gateway and user interface device. A MMUGS sensor consists of the following functions: sensing, processing, and communication. Each sensor is composed of multiple sensing modalities-acoustic, passive-infrared, and seismic. A MMUGS sensor is designed to be low cost and power efficient. This paper will first present: an overview of the sensor architecture and then provide detailed descriptions of sub components. The paper will conclude with a detailed analysis of system performance. This paper is intended to provide. details of the design, integration, and implementation of a MMUGS unit, and demonstrate the overall sensor system performance. This paper does not discuss the network aspect of the system and its affect on performance. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Zong, L (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6287-X J9 P SOC PHOTO-OPT INS PY 2006 VL 6231 BP 23118 EP 23118 AR 623118 DI 10.1117/12.668479 PG 11 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BEU84 UT WOS:000239560800032 ER PT S AU Robertson, DN Pham, T Scanlon, MV Srour, N Reiff, CG Sim, LK Solomon, L Thompson, DF AF Robertson, Dale N. Pham, Tien Scanlon, Michael V. Srour, Nassy Reiff, Christian G. Sim, Leng K. Solomon, Latasha Thompson, Dorothea F. BE Carapezza, EM TI NATO TG-53: Acoustic detection of weapon firing joint field experiment - art. no. 62310V SO Unattended Ground , Sea, and Air Sensor Technologies and Applications VIII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications VIII CY APR 17-20, 2006 CL Kissimmee, FL DE NATO; acoustic; seismic; sensor; aerostat; weapon's firing; mortar; artillery; field experiment AB In this paper, we discuss the NATO Task Group 53 (TG-53) acoustic detection of weapon firing field joint experiment at Yuma Proving Ground during 31 October to 4 November 2005. The participating NATO countries include France, the Netherlands, UK and US. The objectives of the joint experiments are: (i) to collect acoustic signatures of direct and indirect firings from weapons such as sniper, mortar, artillery and C4 explosives and (ii) to share signatures among NATO partners from a variety of acoustic sensing platforms on the ground and in the air distributed over a wide area. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Robertson, DN (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 12 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6287-X J9 P SOC PHOTO-OPT INS PY 2006 VL 6231 BP V2310 EP V2310 AR 62310V DI 10.1117/12.669704 PG 11 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BEU84 UT WOS:000239560800024 ER PT S AU Anderson, TS Fisk, DJ Fiori, JE Decato, SN Punt, DA Lamie, N AF Anderson, Thomas S. Fisk, David J. Fiori, John E. Decato, Stephan N. Punt, Douglas A. Lamie, N. BE Carapezza, EM TI Seismic array monitoring of mortar fire during the November 2005 ARL-NATO TG-53 field experiment at YPG - art. no. 62310W SO Unattended Ground , Sea, and Air Sensor Technologies and Applications VIII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications VIII CY APR 17-20, 2006 CL Kissimmee, FL DE acoustic array; seismic array; seismic detection; source discriminant; seismic localization AB The U.S. Army Corps of Engineers Engineer Research and Development Center (ERDC) participated in a joint ARL-NATO TG-53 field experiment and data collection at Yuma Proving Ground, AZ, in early November 2005. Seismic and acoustic signatures from both muzzle blasts and impacts of small arms fire and artillery were recorded using seven seismic arrays and three acoustic arrays. Arrays composed of 12 seismic and 12 acoustic sensors each were located from 700 m to 18 km from gun positions. Preliminary analysis of signatures attributed to 60-mm, 81-mm, and 120-mm mortars recorded at a seismic-acoustic array 1.1 km from gun position are presented. Seismic and acoustic array f-k analysis is performed to detect and characterize the source signature. Horizontal seismic data are analyzed to determine efficacy of a seismic discriminant for mortar and artillery sources. Rotation of North and East seismic components to radial and transverse components relative to the source-receiver path provide maximum surface wave amplitude on the transverse component. Angles of rotation agree well with frequency-wave number (f-k) analysis of both seismic and acoustic signals. The spectral energy of the rotated transverse surface wave is observable on all caliber of mortars at a distance of 1.1 km and is a reliable source discriminant for mortar sources at this distance. C1 USACE, ERDC, CRREL, Hanover, NH 03755 USA. RP Anderson, TS (reprint author), USACE, ERDC, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6287-X J9 P SOC PHOTO-OPT INS PY 2006 VL 6231 BP W2310 EP W2310 AR 62310W DI 10.1117/12.673729 PG 9 WC Computer Science, Artificial Intelligence; Remote Sensing; Imaging Science & Photographic Technology SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology GA BEU84 UT WOS:000239560800025 ER PT S AU Ly, C Testorf, M Mait, J AF Ly, Canh Testorf, Markus Mait, Joseph BE Gamiz, VL Idell, PS Strojnik, MS TI Range detection through the atmosphere using Laguerre-Gaussian beams SO UNCONVENTIONAL IMAGING II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unconventional Imaging II CY AUG 13-14, 2006 CL San Diego, CA SP SPIE DE paraxial beam propagation; Laguerre-Gaussian beams; range measurement; atmospheric; turbulence; antenna design ID INVARIANT WAVE-FIELDS; FINITE-ENERGY; PROPAGATION; PHASE AB For most radar or ladar systems range information is obtained from the time necessary for an electromagnetic pulse to propagate to a target and return to a receiving antenna. In contrast, we investigate a method that replaces temporal encoding of distance with spatial encoding. In particular, we use a self-referencing superposition of Laguerre-Gaussian beams to translate propagation distance into transverse rotation of cross-section of the beam intensity. We review the mathematical foundations of the technique and discuss models for simulating its performance in turbulent atmosphere. In addition, we present a simple technique to extract the rotation angle from a two-dimensional cross-section of the beam. Preliminary results indicate that the technique is robust with respect to propagation in a turbulent atmosphere. C1 [Ly, Canh; Mait, Joseph] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Testorf, Markus] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Ly, C (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ly@arl.army.mil; markus.e.testorf@dartmouth.edu; jmait@arl.army.mil FU U.S. Army Research Laboratory Director'fs Research Initiative FX This work was funded and supported by U.S. Army Research Laboratory Director's Research Initiative. The research were performed at the U.S. Army Research Laboratory Headquarter, Adelphi, Maryland, and at Thayer School of Engineering, Dartmouth College, Hanover, NH. in U.S.A. NR 17 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6386-8 J9 PROC SPIE PY 2006 VL 6307 AR 630704 DI 10.1117/12.680856 PG 12 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BFI30 UT WOS:000241987300004 ER PT B AU Ingallinella, P Bianchi, E Liang, XP Finotto, M Chastain, M Fan, J Fu, TM Song, HC Horton, M Freed, D Manger, W Wen, E Shi, L Ionescu, R Price, C Wenger, M Emini, E Cortese, R Ciliberto, G Shiver, J Pessi, A AF Ingallinella, Paolo Bianchi, Elisabetta Liang, Xiaoping Finotto, Marco Chastain, Michael Fan, Jiang Fu, Tong-Ming Song, Hong Chang Horton, Melanie Freed, Daniel Manger, Walter Wen, Emily Shi, Li Ionescu, Roxana Price, Colleen Wenger, Marc Emini, Emilio Cortese, Riccardo Ciliberto, Gennaro Shiver, John Pessi, Antonello BE Blondelle, SE TI A universal influenza B peptide vaccine SO UNDERSTANDING BIOLOGY USING PEPTIDES LA English DT Proceedings Paper CT 19th American Peptide Symposium CY JUN 18-23, 2005 CL San Diego, CA SP Amer Peptide Soc, AAPPTEC, Amer Peptide Co, Amer Hlth/GE Healthcare, Amgen, BACHEM, BIOMOL Int, C S Bio Co, Cambridge Res Biochem, Chemico Int, Chem Today, Eli Lilly & Co, ESCOM Sci Fdn, Genentech, Hoffman La Roche, Merck Res Labs, Midwest Bio Tech, NeoMPS Inc, New England BioLabs Inc, Novo Nordisk A S, Peptides Int Inc, PharmaChem Lab, PolyPeptide Labs, RSP Amino Acide LLC, Senn Chem USA, Sinopep Pharmaceut Inc, SynPep Corp, Synthetech, UCB Bioproducts C1 [Ingallinella, Paolo; Bianchi, Elisabetta; Finotto, Marco; Cortese, Riccardo; Ciliberto, Gennaro; Pessi, Antonello] IRBM P Angeletti, Rome, Italy. [Liang, Xiaoping; Chastain, Michael; Fan, Jiang; Fu, Tong-Ming; Song, Hong Chang; Horton, Melanie; Freed, Daniel; Manger, Walter; Wen, Emily; Shi, Li; Ionescu, Roxana; Price, Colleen; Wenger, Marc; Emini, Emilio; Shiver, John] US Mil Acad, Merck Res Labs, West Point, NY 10996 USA. RP Ingallinella, P (reprint author), IRBM P Angeletti, Rome, Italy. NR 3 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 0-387-26569-4 PY 2006 BP 267 EP + DI 10.1007/978-0-387-26575-9_109 PG 2 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BFA80 UT WOS:000240543800109 ER PT B AU Carbin, D Rawale, S Morrison, C Fowler, J Maxwell, L Kaumaya, PTP AF Carbin, Danielle Rawale, Sharad Morrison, Carl Fowler, Jeffrey Maxwell, Larry Kaumaya, Pravin T. P. BE Blondelle, SE TI Design of an antibody for early detection of ovarian cancer SO UNDERSTANDING BIOLOGY USING PEPTIDES LA English DT Proceedings Paper CT 19th American Peptide Symposium CY JUN 18-23, 2005 CL San Diego, CA SP Amer Peptide Soc, AAPPTEC, Amer Peptide Co, Amer Hlth/GE Healthcare, Amgen, BACHEM, BIOMOL Int, C S Bio Co, Cambridge Res Biochem, Chemico Int, Chem Today, Eli Lilly & Co, ESCOM Sci Fdn, Genentech, Hoffman La Roche, Merck Res Labs, Midwest Bio Tech, NeoMPS Inc, New England BioLabs Inc, Novo Nordisk A S, Peptides Int Inc, PharmaChem Lab, PolyPeptide Labs, RSP Amino Acide LLC, Senn Chem USA, Sinopep Pharmaceut Inc, SynPep Corp, Synthetech, UCB Bioproducts C1 [Carbin, Danielle; Rawale, Sharad; Fowler, Jeffrey; Kaumaya, Pravin T. P.] Ohio State Univ, Dept Obstet & Gynecol, Div Vaccine Res, Columbus, OH 43210 USA. [Kaumaya, Pravin T. P.] Arthur G James Comprehens Canc Ctr, Columbus, OH USA. [Morrison, Carl] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA. [Maxwell, Larry] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. RP Carbin, D (reprint author), Ohio State Univ, Dept Obstet & Gynecol, Div Vaccine Res, Columbus, OH 43210 USA. FU GYN Cancer Center FX This work was supported by a GYN Cancer Center Grant. NR 2 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 0-387-26569-4 PY 2006 BP 395 EP + DI 10.1007/978-0-387-26575-9_163 PG 2 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BFA80 UT WOS:000240543800163 ER PT B AU Powell, BS Enama, JT Little, SF Trevino, S Chanh, TC AF Powell, Bradford S. Enama, Jeffrey T. Little, Stephen F. Trevino, Sylvia Chanh, Tran C. BE Blondelle, SE TI Mapping protective epitopes for anthrax and plague vaccine antigens by LC-MS/MS SO UNDERSTANDING BIOLOGY USING PEPTIDES LA English DT Proceedings Paper CT 19th American Peptide Symposium CY JUN 18-23, 2005 CL San Diego, CA SP Amer Peptide Soc, AAPPTEC, Amer Peptide Co, Amer Hlth/GE Healthcare, Amgen, BACHEM, BIOMOL Int, C S Bio Co, Cambridge Res Biochem, Chemico Int, Chem Today, Eli Lilly & Co, ESCOM Sci Fdn, Genentech, Hoffman La Roche, Merck Res Labs, Midwest Bio Tech, NeoMPS Inc, New England BioLabs Inc, Novo Nordisk A S, Peptides Int Inc, PharmaChem Lab, PolyPeptide Labs, RSP Amino Acide LLC, Senn Chem USA, Sinopep Pharmaceut Inc, SynPep Corp, Synthetech, UCB Bioproducts ID BACILLUS-ANTHRACIS; PROTEIN C1 [Powell, Bradford S.; Enama, Jeffrey T.; Little, Stephen F.; Trevino, Sylvia] US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. [Chanh, Tran C.] US Army, Med Res Inst Infect Dis, Headquarters, Frederick, MD USA. RP Powell, BS (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. FU Medical Biological Defense Research Program, U.S. Army Medical Research and Materiel Command [DAM17-98-D-0029, 02-4-CC-010, 02-4-AA-004] FX Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. The research described herein was sponsored in part by the Medical Biological Defense Research Program, U.S. Army Medical Research and Materiel Command, Contract DAM17-98-D-0029,Projects 02-4-CC-010 and 02-4-AA-004 to B. Powell. NR 5 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 0-387-26569-4 PY 2006 BP 692 EP + DI 10.1007/978-0-387-26575-9_307 PG 2 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BFA80 UT WOS:000240543800307 ER PT S AU Nguyen, L Soumekh, M AF Nguyen, Lam Soumekh, Mehrdad BE Gerhart, GR Shoemaker, CM Gage, DW TI System trade analysis for an ultra-wideband forward imaging radar - art. no. 623003 SO Unmanned Systems Technology VIII, Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology VIII CY APR 17-20, 2006 CL Kissimmee, FL SP SPIE DE synthetic aperture radar (SAR); ultra-wideband radar (UWB); forward looking radar ID SYNTHETIC-APERTURE RADAR AB In support of the U.S. Army vision for increased mobility, survivability, and lethality, the Army Research Laboratory is currently developing a new version of the low frequency ultra-wideband (UWB) synthetic aperture radar (SAR) to support forward imaging. One of the goals in the development of this version of the radar is to make it affordable. This paper presents a study of various forward imaging radar configurations that could be employed in a forward imaging radar system to achieve good imaging resolution with a reasonable number of transmitters/receivers. This study provided us with insights to efficiently configure our transmitter/receiver array. In this study, we examined various radar configurations such as monostatic and some variations of bistatic cases. We provide the analysis of the synthetic aperture radar (SAR) image resolution for these configurations and show the effectiveness of the bistatic configuration with only two transmitters at the ends of the physical array. In addition to the analysis, we also provide simulation results to demonstrate the expected imaging resolutions with respect to the radar configuration and the imaging geometry. Finally, we also consider the use of two squinted transmitters at the two ends and exploit the forward motion of the vehicle to form image on the two sides. C1 USA, Res Lab, AMSRL SE RU, Adelphi, MD 20783 USA. RP Nguyen, L (reprint author), USA, Res Lab, AMSRL SE RU, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 7 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6286-1 J9 P SOC PHOTO-OPT INS PY 2006 VL 6230 BP 23003 EP 23003 AR 623003 DI 10.1117/12.666111 PN 1-2 PG 11 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Robotics SC Automation & Control Systems; Computer Science; Robotics GA BEV96 UT WOS:000239711700002 ER PT S AU Karlsen, RE Witus, G AF Karlsen, Robert E. Witus, Gary BE Gerhart, GR Shoemaker, CM Gage, DW TI Vision-based terrain learning - art. no. 623005 SO Unmanned Systems Technology VIII, Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology VIII CY APR 17-20, 2006 CL Kissimmee, FL SP SPIE DE terrain classification; computer vision; machine learning; exemplar memory ID OFF-ROAD NAVIGATION; CLASSIFICATION AB This paper presents an algorithm for online image-based terrain classification that mimics a human supervisor's segmentation and classification of training images into "Go" and "NoGo" regions. The algorithm identifies a set of image chips (or exemplars) in the training images that span the range of terrain appearance. It then uses the exemplars to segment novel images and assign a Go/NoGo classification. System parameters adapt to new inputs, providing a mechanism for learning. System performance is compared to that obtained via offline fuzzy c-means clustering and support vector machine classification. C1 USA, TARDEC, Warren, MI 48397 USA. RP Karlsen, RE (reprint author), USA, TARDEC, Warren, MI 48397 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6286-1 J9 P SOC PHOTO-OPT INS PY 2006 VL 6230 BP 23005 EP 23005 AR 623005 DI 10.1117/12.664427 PN 1-2 PG 10 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Robotics SC Automation & Control Systems; Computer Science; Robotics GA BEV96 UT WOS:000239711700004 ER PT S AU Jaster, JF AF Jaster, Jeffrey F. BE Gerhart, GR Shoemaker, CM Gage, DW TI ARV Robotic Technologies (ART) - A risk reduction effort for future unmanned systems - art. no. 623015 SO Unmanned Systems Technology VIII, Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology VIII CY APR 17-20, 2006 CL Kissimmee, FL SP SPIE DE robotics; future combat systems; armed robotic vehicle; unmanned ground. vehicles; unmanned systems; behaviors; anti-tamper; TARDEC; ATO; ART AB The Army's ARV (Armed Robotic Vehicle) Robotic Technologies (ART) program is working on the development of various technological thrusts for use in the robotic forces of the future. The ART program will develop, integrate and demonstrate the technology required to advance the maneuver technologies (i.e., perception, mobility, tactical behaviors) and increase the survivability of unmanned platforms for the future force while focusing on reducing the soldiers' burden by providing an increase in vehicle autonomy coinciding with a decrease in the total number user interventions required to control the unmanned assets. This program will advance the state of the art in perception technologies to provide the unmanned platform an increasingly accurate view of the terrain that surrounds it; while developing tactical/mission behavior technologies to provide the Unmanned Ground Vehicle (UGV) the capability to maneuver tactically, in conjunction with the manned systems in an autonomous mode. The ART testbed will be integrated with the advanced technology software and associated hardware developed under this effort, and incorporate appropriate mission modules (e.g. RSTA sensors, MILES, etc.) to support Warfighter experiments and evaluations (virtual and field) in a military significant environment (open/rolling and complex/urban terrain). The outcome of these experiments as well as other lessons learned through out the program life cycle will be used to reduce the current risks that are identified for the future UGV systems that will be developed under the Future Combat Systems (FCS) program, including the early integration of an FCS-like autonomous navigation system onto a tracked skid steer platform. C1 USA, TARDEC, AMSRD TAR R, Warren, MI 48397 USA. RP Jaster, JF (reprint author), USA, TARDEC, AMSRD TAR R, MS 264 Jaster, Warren, MI 48397 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6286-1 J9 P SOC PHOTO-OPT INS PY 2006 VL 6230 BP 23015 EP 23015 AR 623015 DI 10.1117/12.664173 PN 1-2 PG 11 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Robotics SC Automation & Control Systems; Computer Science; Robotics GA BEV96 UT WOS:000239711700036 ER PT S AU Lever, JH Shoop, SA AF Lever, James H. Shoop, Sally A. BE Gerhart, GR Shoemaker, CM Gage, DW TI Mobility of lightweight robots over snow - art. no. 623026 SO Unmanned Systems Technology VIII, Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology VIII CY APR 17-20, 2006 CL Kissimmee, FL SP SPIE DE unmanned ground vehicles; traction; motion resistance; sinkage; deep snow AB Snowfields are challenging terrain for lightweight (< 50 kg) unmanned ground vehicles. Deep sinkage, high snow-compaction resistance, traction loss while turning and ingestion of snow into the drive train can cause immobility within a few meters of travel. However, for suitably designed vehicles, deep snow offers a smooth, uniform surface that can obliterate obstacles. Key requirements for good over-snow mobility are low ground pressure, large clearance relative to vehicle size and a drive system that tolerates cohesive snow. A small robot will invariably encounter deep snow relative to its ground clearance. Because a single snowstorm can easily deposit 30 cm of fresh snow, robots with ground clearance less than about 10 cm must travel over the snow rather than gain support from the underlying ground. This can be accomplished using low-pressure tracks (< 1.5 kPa). Even still, snow-compaction resistance can exceed 20% of vehicle weight. Also, despite relatively high traction coefficients for low track pressures, differential or skid steering is difficult because the outboard track can easily break traction as the vehicle attempts to turn against the snow. Short track lengths (relative to track separation) or coupled articulated robots offer steering solutions for deep snow. This paper presents preliminary guidance to design lightweight robots for good mobility over snow based on mobility theory and tests of PackBot, Talon and SnoBot, a custom-designed research robot. Because many other considerations constrain robot designs, this guidance can help with development of winterization kits to improve the over-snow performance of existing robots. C1 USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Lever, JH (reprint author), USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. NR 5 TC 0 Z9 0 U1 2 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6286-1 J9 P SOC PHOTO-OPT INS PY 2006 VL 6230 BP 23026 EP 23026 AR 623026 DI 10.1117/12.664680 PN 1-2 PG 8 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Robotics SC Automation & Control Systems; Computer Science; Robotics GA BEV96 UT WOS:000239711700071 ER PT S AU Cummins, CL Jones, RA Gates, BQ AF Cummins, Christopher L. Jones, Randolph A. Gates, Burhman Q. BE Gerhart, GR Shoemaker, CM Gage, DW TI Application of an off-road mobility model to autonomous cross-country routing of unmanned ground vehicles - art. no. 623029 SO Unmanned Systems Technology VIII, Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology VIII CY APR 17-20, 2006 CL Kissimmee, FL SP SPIE DE robotics; autonomous; NRMM II; standard mobility; AGV; route planning; mobility model AB This paper describes the application of an Army-standard legacy off-road mobility model to cross-country route planning and negotiation by unmanned ground vehicles. A planned route is created from a movement map generated from existing terrain data. An unmanned ground vehicle negotiates the planned route and makes local routing adjustments based on a trafficability assessment of terrain features which are observed from the platform. This research leverages results from other work investigating the scalability of the existing legacy off-road mobility model to small vehicles (< 500 kg). The legacy mobility model is the NATO Reference Mobility Model H (NRMM H), a standard for combat mobility modeling and procurement since the mid-90's. C1 USA, Engineer Res & Dev Ctr, CEERD GM M, Vicksburg, MS 39180 USA. RP Cummins, CL (reprint author), USA, Engineer Res & Dev Ctr, CEERD GM M, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 2 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6286-1 J9 P SOC PHOTO-OPT INS PY 2006 VL 6230 BP 23029 EP 23029 AR 623029 DI 10.1117/12.666176 PN 1-2 PG 11 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Robotics SC Automation & Control Systems; Computer Science; Robotics GA BEV96 UT WOS:000239711700073 ER PT S AU Priddy, JD Jones, RA Gates, BQ Fairley, JR AF Priddy, Jody D. Jones, Randolph A. Gates, Burhman Q. Fairley, Josh R. BE Gerhart, GR Shoemaker, CM Gage, DW TI Establishing UGV power requirements based on mission profiles - art. no. 62302A SO Unmanned Systems Technology VIII, Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology VIII CY APR 17-20, 2006 CL Kissimmee, FL SP SPIE DE UGV; hybrid-electric drive; power storage requirements; resistance forces; mission profiles; terra-mechanics; route analysis AB The propulsion systems employed on unmanned ground vehicle platforms in Future Force Units of Action will likely involve electric or hybrid-electric drive. Power storage systems for these platforms will therefore be driven largely by expected power depletion rates. Resistances that propulsion systems must overcome during maneuvers will be a major factor affecting power depletion rates, and the resistance forces will vary drastically depending on the mission. Therefore, realistic mission-related considerations need to be applied when defining power storage requirements. The US Army has developed numerous models and simulations that use terra-mechanics algorithms to predict maneuver capability for ground vehicles as limited by terrain and environmental factors, and the algorithms employed for predicting maneuver capability in most of these models and simulations are founded on the terra-mechanics algorithms contained in the NATO Reference Mobility Model. The NATO Reference Mobility Model uses physics-based force balancing algorithms with terra-mechanics relationships that were empirically derived from decades of vehicle-terrain interaction research, and it also incorporates proven methodologies for assessing mission effectiveness in terms of maneuver capabilities. The terra-mechanics algorithms and methodologies for assessing mission effectiveness that are implemented in this model and in other related software tools, such as those used for route analysis, can be used to generate realistic mission-related resistance profiles for defining power storage requirements. C1 USA, Engineer Res & Dev Ctr, CEERD GM M, Vicksburg, MS 39180 USA. RP Priddy, JD (reprint author), USA, Engineer Res & Dev Ctr, CEERD GM M, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6286-1 J9 P SOC PHOTO-OPT INS PY 2006 VL 6230 BP A2302 EP A2302 AR 62302A DI 10.1117/12.666289 PN 1-2 PG 9 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Robotics SC Automation & Control Systems; Computer Science; Robotics GA BEV96 UT WOS:000239711700074 ER PT S AU Willoughby, WE Jones, RA Mason, GL Shoop, SA Lever, JH AF Willoughby, William E. Jones, Randolph A. Mason, George L. Shoop, Sally A. Lever, James H. BE Gerhart, GR Shoemaker, CM Gage, DW TI Application of historical mobility testing to sensor-based robotic performance - art. no. 62302B SO Unmanned Systems Technology VIII, Pts 1 and 2 SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology VIII CY APR 17-20, 2006 CL Kissimmee, FL SP SPIE DE mobility testing; mobility history; vehicle modeling; vehicle terrain interaction; terrain characterization; sensor development AB The USA Engineer Research and Development Center (ERDC) has conducted on-/off-road experimental field testing with full-sized and scale-model military vehicles for more than fifty yearn. Some 4000 acres of local terrain are available for tailored field evaluations or verification/validation of future robotic designs in a variety of climatic regimes. Field testing and data collection procedures, as well as techniques for quantifying terrain in engineering terms, have been developed and refined into algorithms and models for predicting vehicle-terrain interactions and resulting forces or speeds of military-sized vehicles. Based on recent experiments with Matilda, Talon, and Pacbot, these predictive capabilities appear to be relevant to most robotic systems currently in development. Utilization of current testing capabilities with sensor-based vehicle drivers, or use of the procedures for terrain quantification from sensor data, would immediately apply some fifty years of historical knowledge to the development, refinement, and implementation of future robotic systems. Additionally, translation of sensor-collected terrain data into engineering terms would allow assessment of robotic performance a priori deployment of the actual system and ensure maximum system performance in the theater of operation. C1 USA, Engineer Res & Dev Ctr, CEERD GM M, Vicksburg, MS 39180 USA. RP Willoughby, WE (reprint author), USA, Engineer Res & Dev Ctr, CEERD GM M, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6286-1 J9 P SOC PHOTO-OPT INS PY 2006 VL 6230 BP B2302 EP B2302 AR 62302B DI 10.1117/12.666544 PN 1-2 PG 8 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Robotics SC Automation & Control Systems; Computer Science; Robotics GA BEV96 UT WOS:000239711700075 ER PT S AU Smuda, WJ Gerhart, G Shing, MT Auguston, M AF Smuda, William J. Gerhart, Grant Shing, Man-Tak Auguston, Mikhail BE Carapezza, EM TI A software design approach for heterogeneous systems of unattended sensors, unmanned vehicles and monitoring stations SO UNMANNED/UNATTENDED SENSORS AND SENSOR NETWORKS III SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned/Unattended Sensors and Sensor Networks III CY SEP 11-12, 2006 CL Stockholm, SWEDEN DE software design; unattended sensors; unmanned vehicles; model driven design; software reuse; UML; distributed systems; design patterns; software components; JAUS AB The design and implementation of software for network systems of diverse physical assets is a continuing challenge to sensor network developers. The problems are often multiplied when adding new elements, and when reconfiguring existing systems. For software systems, like physical systems, explicit architectural descriptions increase system level comprehension. Coupled with well defined object oriented design practices, system extensibility is defined and software reuse and code composition are enabled. Our research is based on model driven design architecture. High level system models are defined in the Unified Modeling Language (UML), the language of the software engineer. However, since most experimental work is done by non-software specialists, (electronics Engineers, Mechanical Engineers and technicians) the model is translated into a graphical, domain specific model. Components are presented as domain specific icons, and constraints from the UML model are propagated into the domain model. Domain specialists manipulate the domain model, which then composes software elements needed at each node to create an aggregate system. C1 USA, Tank Automot RDE Ctr, Warren, MI 48397 USA. RP Smuda, WJ (reprint author), USA, Tank Automot RDE Ctr, 6501 E 11 Mile Rd, Warren, MI 48397 USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-6492-7 J9 PROC SPIE PY 2006 VL 6394 DI 10.1117/12.693035 PG 11 WC Instruments & Instrumentation; Optics; Physics, Applied SC Instruments & Instrumentation; Optics; Physics GA BFR20 UT WOS:000243928500002 ER PT B AU Flavin, W AF Flavin, William BE Ganguly, S Shoup, B Scobell, A TI US ARMY'S NEW PEACE OPERATIONS ERA SO US-INDIAN STRATEGIC COOPERATION INTO THE 21ST CENTURY: MORE THAN WORDS SE Asian Security Studies LA English DT Article; Book Chapter C1 [Flavin, William] USA, Peacekeeping & Stabil Operat Inst, War Coll, Carlisle, PA USA. RP Flavin, W (reprint author), USA, Peacekeeping & Stabil Operat Inst, War Coll, Carlisle, PA USA. NR 33 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE & KEGAN PAUL INC PI NEW YORK PA 29 WEST 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-94674-9 J9 ASIAN SECUR STUD PY 2006 BP 207 EP 220 PG 14 WC Political Science SC Government & Law GA BMG04 UT WOS:000272245500011 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI The US Military Profession into the Twenty-First Century War, peace and politics Introduction SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Editorial Material; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 251 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 1 EP + PG 16 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000001 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI War, peace and politics SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 53 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 9 EP + PG 19 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000002 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI The military profession SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 43 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 25 EP + PG 16 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000003 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI Politics and the military A historical introduction SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 41 EP + PG 22 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000004 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI Civil-military relations SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 46 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 59 EP + PG 21 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000005 ER PT J AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI Civilian and military cultures SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 34 TC 1 Z9 1 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 77 EP + PG 17 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000006 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI The national security system SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 92 EP + PG 18 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000007 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI The new world order Military implications SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 18 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 111 EP + PG 13 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000008 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI US strategy and national interests SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 23 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 122 EP + PG 10 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000009 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI From old war to new war SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 43 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 130 EP + PG 15 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000010 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI Military force and operational parameters SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 142 EP + PG 15 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000011 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI Mainstream military and Special Operations Forces Force structure and doctrine SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 42 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 154 EP + PG 17 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000012 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI The President: Civilian and military cultures SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 171 EP + PG 11 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000013 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI Constructive political engagement SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Article; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 180 EP + PG 9 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000014 ER PT B AU Sarkesian, SC Connor, RE AF Sarkesian, Sam C. Connor, Robert E., Jr. BA Sarkesian, S Connor, RE BF Sarkesian, S Connor, RE TI Into the twenty-first century SO US MILITARY PROFESSION INTO THE 21ST CENTURY: WAR, PEACE AND POLITICS, SECOND EDITION SE Cass Military Studies LA English DT Editorial Material; Book Chapter C1 [Sarkesian, Sam C.] Loyola Univ, Chicago, IL 60611 USA. [Connor, Robert E., Jr.] Triton Int Univ, Chicago, IL USA. [Sarkesian, Sam C.; Connor, Robert E., Jr.] USA, Washington, DC USA. [Connor, Robert E., Jr.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Sarkesian, SC (reprint author), Loyola Univ, Chicago, IL 60611 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-00472-2 J9 CASS MIL STUD PY 2006 SI 2 BP 188 EP + PG 10 WC History; Political Science SC History; Government & Law GA BMF95 UT WOS:000272228000015 ER PT S AU Raftery, JJ Lehman, AC Danner, AJ Leisher, PO Giannopoulos, AV Choquette, KD AF Raftery, James J., Jr. Lehman, Ann C. Danner, Aaron J. Leisher, Paul O. Giannopoulos, Antonios V. Choquette, Kent D. BE Lei, C Choquette, KD TI Coherent transverse coupling in photonic crystal vertical cavity laser arrays - art. no. 61420I SO Vertical-Cavity Surface-Emitting Lasers X SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Vertical-Cavity Surface-Emitting Lasers X CY JAN 25-26, 2006 CL San Jose, CA SP SPIE DE coherent array; VCSEL array; photonic crystal VCSEL ID SURFACE-EMITTING LASERS; PHASED-ARRAY; FABRICATION AB Coherent transverse coupling in 2 x 2 arrays of defect cavities in photonic crystal (PhC) vertical cavity surface emitting lasers (VCSELs) is reported. Modification of the effective index and optical loss by design of the photonic crystal hole pattern results in evanescent Coupling between the multiple defect cavities of a PhC VCSEL. Fabrication processes for these devices are discussed. Far field measurements are utilized to demonstrate both the out-of-phase and in-phase results. Room temperature continuous wave operating characteristics for the devices are provided, and a quantitative description of the coherently coupled operation is presented. The resulting agreement between the simulated and observed far fields is shown. C1 US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. RP Raftery, JJ (reprint author), US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. NR 19 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6174-1 J9 P SOC PHOTO-OPT INS PY 2006 VL 6132 BP I1420 EP I1420 AR 61420I DI 10.1117/12.660848 PG 8 WC Optics SC Optics GA BEF38 UT WOS:000237084500015 ER PT B AU Rosario, D AF Rosario, Dalton GP INSTICC TI Novel asymmetric variance-based hypothesis test for a difficult surveillance problem SO VISAPP 2006: Proceedings of the First International Conference on Computer Vision Theory and Applications, Vol 1 LA English DT Proceedings Paper CT 1st International Conference on Computer Vision Theory and Applications CY FEB 25-28, 2006 CL Polytechn Inst Setubal, Business Sch, Setubal, PORTUGAL SP Inst Syst & Technologies Informat, Control & Commun, Setubal Polytechn Inst HO Polytechn Inst Setubal, Business Sch DE anomaly detection; asymmetric hypothesis test; hyperspectral imagery ID HYPERSPECTRAL IMAGERY; ANOMALY DETECTION AB Local anomaly detectors have become quite popular for applications requiring hyperspectral (HS) target detection in natural clutter background assisted by an image analyst. Their popularity may be attributed to the simplicity of the algorithms designed to function as such. A disadvantage of using such detectors, however, is that they often produce an intolerable high number of detections per scene, which-according to image analysts-becomes a nuisance rather than an aiding tool. We present an effective local anomaly detector for HS data. The new detector exploits a notion of indirect comparison between two sets of samples and is free from distribution assumptions. The notion led us to derive a compact solution for a variance test, in which, under the null hypothesis, the detector's performance converges to a known distribution. Experimental results using both simulated multivariate data and real HS data are presented to illustrate the effectiveness of this detector over five known alternative techniques. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Rosario, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU INSTICC-INST SYST TECHNOLOGIES INFORMATION CONTROL & COMMUNICATION PI SETUBAL PA AVENIDA D MANUEL L, 27A 2 ESQUERDO, SETUBAL, 2910-595, PORTUGAL BN 972-8865-40-6 PY 2006 BP 277 EP 284 PG 8 WC Computer Science, Artificial Intelligence SC Computer Science GA BFH74 UT WOS:000241913400041 ER PT J AU White, PM Wolf, DC Thoma, GJ Reynolds, CM AF White, PM Wolf, DC Thoma, GJ Reynolds, CM TI Phytoremediation of alkylated polycyclic aromatic hydrocarbons in a crude oil-contaminated soil SO WATER AIR AND SOIL POLLUTION LA English DT Article DE biodegradation; natural attenuation; phytotransformation; rhizosphere enhanced remediation; total petroleum hydrocarbons ID PROBABLE-NUMBER PROCEDURE; MICROBIAL-POPULATIONS; MATHEMATICAL-MODEL; RHIZOSPHERE; DEGRADATION; BIODEGRADATION; PHENANTHRENE; BIOREMEDIATION; DISSIPATION; ENRICHMENT AB Phytoremediation uses plants and their associated microorganisms in conjunction with agronomic techniques to remove or degrade environmental contaminants. The objective of the field study was to evaluate the effect of vegetation establishment plus fertilizer addition on the biodegradation of alkylated polycyclic aromatic hydrocarbons in a crude oil-contaminated soil. Four replications of the following treatments were used: non-vegetated non-fertilized control; fescue (Lolium arundinaceum Schreb.) - ryegrass (Lolium multiflorum L.) mixture + fertilizer; or bermudagrass (Cynodon dactylon (L.) Pers.) - fescue mixture + fertilizer. Vegetation was successfully established at the site that had an initial total petroleum hydrocarbon (TPH) concentration of 9,175 mg/kg. While alkylated two-ring naphthalenes were degraded in all treatments equally, there was greater degradation of the larger three-ring alkylated phenanthrenes-anthracenes and dibenzothiophenes in the vegetated fertilized plots compared to the non-vegetated non-fertilized plots. In this field study, an increase in rhizosphere soil volume associated with increased root length along with nutrient additions resulted in increased total bacterial, fungal, and polycyclic aromatic hydrocarbon (PAH) degrader numbers that most likely resulted in increased biodegradation of the more recalcitrant alkylated polycyclic aromatic hydrocarbon compounds in the crude oil-contaminated soil. C1 Univ Arkansas, Dept Crop & Soil Environm Sci, Fayetteville, AR 72701 USA. Kansas State Univ, Dept Agron, Manhattan, KS 66506 USA. Univ Arkansas, Dept Chem Engn, Fayetteville, AR 72701 USA. Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Wolf, DC (reprint author), Univ Arkansas, Dept Crop & Soil Environm Sci, Fayetteville, AR 72701 USA. EM dwolf@uark.edu NR 41 TC 54 Z9 59 U1 4 U2 33 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0049-6979 J9 WATER AIR SOIL POLL JI Water Air Soil Pollut. PD JAN PY 2006 VL 169 IS 1-4 BP 207 EP 220 DI 10.1007/s11270-006-2194-0 PG 14 WC Environmental Sciences; Meteorology & Atmospheric Sciences; Water Resources SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Water Resources GA 998JP UT WOS:000234315000012 ER PT J AU Oh, SY Cha, DK Chiu, PC Kim, BJ AF Oh, S. -Y. Cha, D. K. Chiu, P. C. Kim, B. J. TI Zero-valent iron treatment of RDX-containing and perchlorate-containing wastewaters from an ammunition-manufacturing plant at elevated temperatures SO WATER SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 5th World Water Congress of the International-Water-Association CY SEP 10-14, 2006 CL Beijing, PEOPLES R CHINA DE ammunition wastewater; perchlorate; RDX; reduction; zero-valent iron ID ELEMENTAL IRON; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; IONS; TRANSFORMATION; PRETREATMENT; DEGRADATION; ADSORPTION; REDUCTION; ACID AB The use of zero-valent iron for treating wastewaters containing RDX and perchlorate from an army ammunition plant (AAP) in the USA at elevated temperatures and moderately elevated temperature with chemical addition was evaluated through batch and column experiments. RDX in the wastewater was completely removed in an iron column after 6.4 minutes Increasing the temperature to 75 degrees C decreased the required retention time to 2.1 minutes for complete RDX removal. Perchlorate in the wastewater was completely removed by iron at an elevated temperature of 150 degrees C in batch reactors in 6 hours without pH control. Significant reduction of perchlorate by zero-valent iron was also achieved at a more moderate temperature (75 degrees C) through use of a 0.2 M acetate buffer. Based on the evaluation results, we propose two innovative processes for treating RDX-containing and perchlorate-containing wastewaters: a temperature and pressure-controlled batch iron reactor and subsequent oxidation by existing industrial wastewater treatment plant; and reduction by consecutive iron columns with heating and acid addition capabilities and subsequent oxidation. C1 Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. USA, Engn Res & Dev Ctr, Champaign, IL 61826 USA. RP Oh, SY (reprint author), Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. EM quartzoh@ce.udel.edu; cha@ce.udel.edu; pei@ce.udel.edu; b-kim@cecer.army.mil NR 17 TC 7 Z9 7 U1 0 U2 8 PU I W A PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 0273-1223 J9 WATER SCI TECHNOL JI Water Sci. Technol. PY 2006 VL 54 IS 10 BP 47 EP 53 DI 10.2166/wst.2006.886 PG 7 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 114PU UT WOS:000242678900008 PM 17165447 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Chance and Variation SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP 1 EP 36 D2 10.1142/9789812773098 PG 36 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400002 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI WHERE MEDICINE WENT WRONG Rediscovering the Path to Complexity Prologue SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Editorial Material; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP IX EP + D2 10.1142/9789812773098 PG 13 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400001 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI The Expectation of Health SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP 37 EP 68 D2 10.1142/9789812773098 PG 32 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400003 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Even Uncertainty has Laws SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP 69 EP 117 D2 10.1142/9789812773098 PG 49 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400004 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI The Uncertainty of Health SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP 119 EP 172 D2 10.1142/9789812773098 PG 54 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400005 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Fractal Physiology SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP 173 EP 240 D2 10.1142/9789812773098 PG 68 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400006 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Complexity SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP 241 EP 281 D2 10.1142/9789812773098 PG 41 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400007 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI Disease as Loss of Complexity SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Article; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP 283 EP 314 D2 10.1142/9789812773098 PG 32 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400008 ER PT S AU West, BJ AF West, Bruce J. BA West, BJ BF West, BJ TI WHERE MEDICINE WENT WRONG Rediscovering the Path to Complexity Epilogue SO WHERE MEDICINE WENT WRONG: REDISCOVERING THE PATH TO COMPLEXITY SE Studies of Nonlinear Phenomena in Life Science LA English DT Editorial Material; Book Chapter C1 USA, Res Off, Washington, DC USA. RP West, BJ (reprint author), USA, Res Off, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE SN 1793-1428 BN 978-981-277-309-8 J9 STUD NONLIN PHENOM PY 2006 VL 11 BP 315 EP 316 D2 10.1142/9789812773098 PG 2 WC History & Philosophy Of Science SC History & Philosophy of Science GA BZQ91 UT WOS:000302429400009 ER PT J AU Corum, JS AF Corum, James S. BE Higham, R Harris, SJ TI Defeat of the Luftwaffe, 1935-1945 SO WHY AIR FORCES FAIL: THE ANATOMY OF DEFEAT LA English DT Article; Book Chapter C1 [Corum, James S.] USAF, Sch Adv Airpower Studies, Maxwell AFB, AL USA. RP Corum, JS (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU UNIV PRESS KENTUCKY PI LEXINGTON PA 102 LAFFERTY HALL, UNIVERSITY OF KENTUCKY, LEXINGTON, KY 40506 USA BN 978-0-8131-7174-6 PY 2006 BP 203 EP 226 PG 24 WC History SC History GA BAV12 UT WOS:000305581000008 ER PT S AU Luu, BB Gopaul, RD AF Luu, Brian B. Gopaul, Richard D. BE Rao, RM Dianat, SA Zoltowski, MD TI Wireless LAN signal strength in a 3-story cinderblock building - art. no. 62480C SO Wireless Sensing and Processing SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Wireless Sensing and Processing CY APR 17-18, 2006 CL Kissimmee, FL SP SPIE DE wireless LAN; 802.11a; 802.11g; signal strength; signal amplifier; antenna AB The U.S. Army Research Laboratory, in support of network communications for a Horizontal Fusion program, experimented with large-scale wireless LANs at the McKenna facility in Fort Benning, GA. In total, we deployed two wireless LANs, one consisting of both the 802.11A and 802.11G protocols and the other consisting of only the 802.11G protocol. In this paper, we will describe the deployment of wireless LAN access points and show the mapping of wireless LAN signal strength reception in rooms of building B1 of McKenna village at Fort Benning, GA. We will also describe our observations in using these wireless LANs. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Luu, BB (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 0-8194-6304-3 J9 P SOC PHOTO-OPT INS PY 2006 VL 6248 BP C2480 EP C2480 AR 62480C DI 10.1117/12.665101 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BES11 UT WOS:000239236300010 ER PT B AU Wong, E Goerger, N Keeter, R Goerger, S AF Wong, Ernest Goerger, Niki Keeter, Robert Goerger, Simon BE Callaos, N Lesso, W Yoshida, E Choo, J TI Creating the army digital terrain Catalog - A case study in rapid prototyping and allowing market forces to help determine standards SO WMSCI 2006: 10TH WORLD MULTI-CONFERENCE ON SYSTEMICS, CYBERNETICS AND INFORMATICS, VOL III, PROCEEDINGS LA English DT Proceedings Paper CT 10th World Multi-Conference on Systemics, Cybernetics and Informatics/12th International Conference on Information Systems Analysis and Synthesis CY JUL 16-19, 2006 CL Orlando, FL SP Int Inst Informat & System DE modeling and simulation; rapid prototyping; terrain database repositories; US military; systems engineering; information systems AB Used to improve military effectiveness in responding to emerging threats, enhance warfighting readiness, and reduce operating costs, simulations have become commonplace in nearly all areas of the United States Armed Forces. From material acquisition to force structure analysis, from first-person video-game shooters to network-centric battle staff exercises, simulations have progressed into becoming intrinsic components of nearly all aspects of the military landscape. As the military has become more accustomed to using simulations and its expectations have grown about simulation capabilities, the demand and need for more realistic virtual and constructive environments have increased. Accordingly, there have been escalating demands on the modeling and simulation (M&S) community to incorporate greater fidelity and resolution of the natural and manmade environment and systems interaction in the battlespace to make the simulation experience increasingly more realistic and complete. Unfortunately, this has increased the cost of developing simulations and their associated terrain databases, both in terms of price as well as time. This report documents how the Operations Research Center of Excellence within the Department of Systems Engineering at the United States Military Academy has employed systems engineering principles to help address the rising cost of M&S development. Specifically, this report discusses the design and development of the Army Digital Terrain Catalog to help promote discovery, accessibility, and reuse of digital terrain databases-a key component of M&S that helps drive analysis, acquisition, and training for our Armed Forces. C1 [Wong, Ernest; Keeter, Robert; Goerger, Simon] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Wong, E (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU INT INST INFORMATICS & SYSTEMICS PI ORLANDO PA 14269 LORD BARCLAY DR, ORLANDO, FL 32837 USA BN 978-980-6560-68-0 PY 2006 BP 99 EP 104 PG 6 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics; Computer Science, Information Systems SC Computer Science GA BHA57 UT WOS:000251937300032 ER PT B AU Pinsky, J AF Pinsky, Judith BE Callaos, N Horimoto, K Fujikawa, T Bemley, J Tolk, A Su, JS Porteus, J TI Using ontologies to harmonize data models among communities of interest (COIs) SO WMSCI 2006: 10TH WORLD MULTI-CONFERENCE ON SYSTEMICS, CYBERNETICS AND INFORMATICS, VOL IV, PROCEEDINGS LA English DT Proceedings Paper CT 10th World Multi-Conference on Systemics, Cybernetics and Informatics/12th International Conference on Information Systems Analysis and Synthesis CY JUL 16-19, 2006 CL Orlando, FL SP Int Inst Informat & System DE ontology; OWL; interoperability; harmonization; OMIA; SEC; model AB Part of the U.S. Army Communications-Electronics Life Cycle Management Command (C-E LCMC) Software Engineering Center's (SEC's) Mission is to facilitate the execution of the Army's Net Centric Data Strategy and provide users with common and overarching data products and services to promote interoperability and faster access, retrieval, analysis and utilization of data. In accordance with this Mission, SEC initiated the following efforts: Designed and developed the Command, Control, Communications, and Computers, Intelligence, Surveillance and Reconnaissance (C4ISR) Data Ontology. Designed the application suite known as the Ontology and Model Integration Application (OMIA). The purpose of this paper is to present an overview of both the C4ISR Data Ontology and OMIA efforts and products. This overview includes the reason behind these efforts, the initial approach that was taken in the design of each product, and the decisions that were made along the way to reach the products that exist today. This paper will be presented in the invited session "Ontology Driven Interoperability for Agile Applications using Information Systems: Requirements and Applications for Agent Mediated Decision Support" of WMSCI 2006. C1 USA, Commun Elect Life Cycle Management Command, SEC, Ft Monmouth, NJ 07724 USA. RP Pinsky, J (reprint author), USA, Commun Elect Life Cycle Management Command, SEC, Ft Monmouth, NJ 07724 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU INT INST INFORMATICS & SYSTEMICS PI ORLANDO PA 14269 LORD BARCLAY DR, ORLANDO, FL 32837 USA BN 978-980-6560-69-7 PY 2006 BP 88 EP 98 PG 11 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics; Computer Science, Information Systems SC Computer Science GA BHA58 UT WOS:000251937800018 ER PT J AU Abbott, CA Dremsa, T Stewart, DW Mark, DD Swift, CC AF Abbott, Cynthia A. Dremsa, Theresa Stewart, Della W. Mark, Debra D. Swift, Caren C. TI Adoption of a ventilator-associated pneumonia clinical practice guideline SO WORLDVIEWS ON EVIDENCE-BASED NURSING LA English DT Article DE evidence-based practice; ventilator-associated pneumonia; clinical practice guideline; infection control; VAP rates; infection prevention ID INTENSIVE-CARE-UNIT; RECEIVING MECHANICAL VENTILATION; RISK-FACTORS; NOSOCOMIAL PNEUMONIA; BODY POSITION; COLONIZATION; INFECTION; ICU; ASPIRATION; MORTALITY AB Conceptual Framework: The Academic Center for Evidence-based Practice (ACE) Star Model was used to implement an evidence-based clinical practice guideline (CPG) in order to decrease ventilator-associated pneumonia (VAR) incidence rates and ventilator days. The goal was to interrupt person-to-person transmission of bacteria and bacterial colonization using low-cost, evidence-based strategies to prevent VAP. Discovery: Two geographically proximate medical centers, inclusive of five intensive care units located in the southwestern region of the United States had significant variations in their VAP rates. Evidence summary: Using the U.S. Preventive Services Task Force grading criteria, the results of 69 studies were used to establish a clinical practice guideline to prevent ventilator-associated pneumonia. Translation: A clinical practice guideline was developed for the prevention of VAR and included five nursing activities: (a) head-of-bed elevation; (b) oral care; (c) ventilator tubing condensate removal; (d) hand hygiene; and (e) glove use. The effect of the CPG, inclusive of an educational intervention, was measured using an observational, prospective, quasi-experimental design. Integration: A multidisciplinary education team developed a self-learning packet, educational materials, and storyboards for the staff as dissemination strategies. Strategies also included e-mail, one-on-one teaching with clinicians, and feedback on guideline adoption and VAP rate reports. Evaluation: Observation data were collected to evaluate adoption of the CPG while caring for 106 ventilated patients. VAR rates changed at both hospitals although the change was not statistically significant. Additionally, the ICU length of stay declined at both facilities, causing cost savings. Discussion: These results support the idea that adoption of evidence-based practices contributes to decreased VAP rates. For a successful program, ICU leaders should emphasize strategies that routinize adoption of evidence-based CPGs. RP Mark, DD (reprint author), Tripler Army Med Ctr, Nursing Res Serv, Dept Nursing, MCHK-DN,1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Debra.mark@us.army.mil NR 43 TC 24 Z9 26 U1 0 U2 6 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1545-102X J9 WORLDV EVID-BASED NU JI Worldviews Evid.-Based Nurs. PY 2006 VL 3 IS 4 BP 139 EP 152 DI 10.1111/j.1741-6787.2006.00066.x PG 14 WC Nursing SC Nursing GA 114QD UT WOS:000242679800002 PM 17177928 ER PT B AU Norton, DP Pearton, SJ Zavada, JM Chen, WM Buyanova, IA AF Norton, D. P. Pearton, S. J. Zavada, J. M. Chen, W. M. Buyanova, I. A. BE Jagadish, C Pearton, SJ TI Ferromagnetism in ZnO Doped with Transition Metal Ions SO ZINC OXIDE BULK, THIN FILMS AND NANOSTRUCTURES: PROCESSING, PROPERTIES AND APPLICATIONS LA English DT Article; Book Chapter ID DILUTED MAGNETIC SEMICONDUCTORS; ELECTRICAL SPIN INJECTION; LIGHT-EMITTING-DIODES; THIN-FILMS; ROOM-TEMPERATURE; ELECTRONIC-STRUCTURE; MATERIALS DESIGN; ZINC-OXIDE; OPTICAL-PROPERTIES; SINGLE-CRYSTALS AB Spin-dependent phenomena in wide bandgap semiconductors such as ZnO may lead to devices with new or enhanced functionality, such as polarized solid-state light sources (spin light-emitting diodes), novel microprocessors and sensitive biological and chemical sensors. In this paper we review experimental results on transition metal doping of ZnO and the current state of theories for the ferromagnetism. It is important to re-examine some of the earlier concepts for spintronics devices, such as the spin field-effect transistor, to account for the presence of the strong magnetic field which has deleterious effects. In some of these cases, the spin device appears to have no advantage relative to the conventional charge-control electronic analog. The most promising materials for room temperature polarized light emission are expected to be GaN and ZnO, but progress on realizing devices has been disappointing. To date we have been unable to detect optical spin polarization in ZnO. The short spin-relaxation time observed likely results from the Rashba effect. Possible solutions involve either cubic phase ZnO or use of additional stressor layers to create a larger spin-splitting in order to get polarized light emission from these structures or to look at alternative semiconductors and fresh device approaches. C1 [Norton, D. P.; Pearton, S. J.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Zavada, J. M.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Chen, W. M.; Buyanova, I. A.] Linkoping Univ, Dept Phys & Measurement Technol, S-58183 Linkoping, Sweden. RP Norton, DP (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. NR 85 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-046403-9; 978-0-08-044722-3 PY 2006 BP 555 EP 576 DI 10.1016/B978-008044722-3/50016-6 PG 22 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Coatings & Films SC Engineering; Science & Technology - Other Topics; Materials Science GA BCS44 UT WOS:000311278400017 ER PT J AU Geyer, JA Prigge, ST Waters, NC AF Geyer, JA Prigge, ST Waters, NC TI Targeting malaria with specific CDK inhibitors SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS LA English DT Article; Proceedings Paper CT 4th International Conference on Inhibitors of Protein Kinases (IPK 2005) CY JUN 25-29, 2005 CL Warsaw, POLAND DE cyclin dependent protein kinase; Plmrk; Plasmodium falciparum; malaria; CDK inhibitor ID CYCLIN-DEPENDENT KINASES; PARASITE PLASMODIUM-FALCIPARUM; CYSTEINE PROTEASE INHIBITORS; POTENT ANTIMALARIAL ACTIVITY; FATTY-ACID SYNTHASE; IN-VITRO ACTIVITY; CELL-CYCLE; FUNCTIONAL-CHARACTERIZATION; DRUG-RESISTANCE; DIHYDROFOLATE-REDUCTASE AB Cyclin-dependent protein kinases (CDKs) are attractive targets for drug discovery and efforts have led to the identification of novel CDK selective inhibitors in the development of treatments for cancers, neurological disorders, and infectious diseases. More recently, they have become the focus of rational drug design programs for the development of new antimalarial agents. CDKs are valid targets as they function as essential regulators of cell growth and differentiation. To date, several CDKs have been characterized from the genome of the malaria-causing protozoan Plasmodium falciparum. Our approach employs experimental and virtual screening methodologies to identify and refine chemical inhibitors of the parasite CDK Pfmrk, a sequence homologue of human CDK7. Chemotypes of Pfmrk inhibitors include the purines, quinolinones, oxindoles, and chalcones, which have sub-micromolar IC50 values against the parasite enzyme, but not the human CDKs. Additionally, we have developed and validated a pharmacophore, based on Pfmrk inhibitors, which contains two hydrogen bond acceptor functions and two hydrophobic sites, including one aromatic ring hydrophobic site. This pharmacophore has been exploited to identify additional compounds that demonstrate significant inhibitory activity against Pfmrk. A molecular model of Pfmrk designed using the crystal structure of human CDK7 highlights key amino acid substitutions in the ATP binding pocket. Molecular modeling and docking of the active site pocket with selective inhibitors has identified possible receptor-ligand interactions that may be responsible for inhibitor specificity. Overall, the unique biochemical characteristics associated with this protein, to include distinctive active site amino acid residues and variable inhibitor profiles, distinguishes the Pfmrk drug screen as a paradigm for CDK inhibitor analysis in the parasite. Published by Elsevier B.V. C1 USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 20910 USA. Johns Hopkins Bloomberg Sch Publ Hlth, Malaria Res Inst, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Geyer, JA (reprint author), USA, Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 20910 USA. EM Jeanne.Geyer@det.amedd.army.mil NR 75 TC 33 Z9 35 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-9639 J9 BBA-PROTEINS PROTEOM JI BBA-Proteins Proteomics PD DEC 30 PY 2005 VL 1754 IS 1-2 SI SI BP 160 EP 170 DI 10.1016/j.bbapap.2005.07.031 PG 11 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 999AK UT WOS:000234360800016 PM 16185941 ER PT J AU Warren, SD Mitasova, H Hohmann, MG Landsberger, S Iskander, FY Ruzycki, TS Senseman, GM AF Warren, SD Mitasova, H Hohmann, MG Landsberger, S Iskander, FY Ruzycki, TS Senseman, GM TI Validation of a 3-D enhancement of the Universal Soil Loss Equation for prediction of soil erosion and sediment deposition SO CATENA LA English DT Article DE erosion modeling; Cs-137; USLE; unit stream power theory; sediment deposition ID LENGTH-SLOPE FACTORS; FALLOUT CS-137; GIS; RADIONUCLIDES; RUSLE; USLE; APPLICABILITY; CESIUM-137; VEGETATION; SYSTEM AB A study was conducted on three U.S. military training areas to validate the Unit Stream Power Erosion and Deposition (USPED) model, a 3-dimensional enhancement to the Universal Soil Loss Equation (USLE). The USPED model differs from other USLE-based models in the manner in which it handles the influence of topography on the erosion process. As a result, the USPED model predicts both erosion and deposition, while most other USLE-based models are limited to predictions of erosion only. Erosion and deposition from a small watershed at Fort Hood, Texas, USA was quantified using Cs-137, a radioactive isotope found in soils around the world as a result of fallout from post-World War II nuclear testing. We compared Cs-137-derived erosion/deposition measurements with estimates derived from the USPED model and two applications of the USLE. Soil erosion and sediment deposition estimates generated by the USPED model were more accurate and less biased than results of the USLE applications. Both applications of the USLE consistently and significantly overestimated soil erosion; the USPED model did not. The USPED model was subsequently applied to Camp Guernsey, Wyoming, USA and Fort McCoy, Wisconsin, USA. Model estimates of soil erosion and sediment deposition were compared with field estimates of the same parameters. Based on 3 levels of soil erosion and 3 levels of sediment deposition, the model results agreed with field estimates 76 and 89% of the time at the two locations, respectively. (c) 2005 Elsevier B.V. All rights reserved. C1 Colorado State Univ, Ctr Environm Management Mil Lands, Ft Collins, CO 80523 USA. N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA. USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. Univ Texas, Nucl Engn Teaching Lab, Austin, TX 78712 USA. RP Warren, SD (reprint author), Colorado State Univ, Ctr Environm Management Mil Lands, Ft Collins, CO 80523 USA. EM swarren@cemml.colostate.edu OI Mitasova, Helena/0000-0002-6906-3398 NR 48 TC 21 Z9 24 U1 2 U2 23 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0341-8162 EI 1872-6887 J9 CATENA JI Catena PD DEC 30 PY 2005 VL 64 IS 2-3 BP 281 EP 296 DI 10.1016/j.catena.2005.08.010 PG 16 WC Geosciences, Multidisciplinary; Soil Science; Water Resources SC Geology; Agriculture; Water Resources GA 001JK UT WOS:000234529200011 ER PT J AU Wcislo, WT AF Wcislo, WT TI Social labels: we should emphasize biology over terminology and not vice versa SO ANNALES ZOOLOGICI FENNICI LA English DT Article ID BEHAVIOR; BEES C1 Smithsonian Trop Res Inst, Balboa, Panama. RP Wcislo, WT (reprint author), USA, STRI, Unit 0948, APO, AA 34002 USA. EM wcislow@si.edu NR 20 TC 6 Z9 6 U1 0 U2 7 PU FINNISH ZOOLOGICAL BOTANICAL PUBLISHING BOARD PI UNIV HELSINKI PA P O BOX 17, FIN-00014 UNIV HELSINKI, FINLAND SN 0003-455X J9 ANN ZOOL FENN JI Ann. Zool. Fenn. PD DEC 21 PY 2005 VL 42 IS 6 BP 565 EP 568 PG 4 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 002DV UT WOS:000234592600003 ER PT J AU Lee, C Danon, Y Mulligan, C AF Lee, C Danon, Y Mulligan, C TI Characterization of niobium, tantalum and chromium sputtered coatings on steel using eddy currents SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE eddy currents; sputtered coatings; resistivity of coatings; sputtering conditions ID THIN-FILMS; MICROSTRUCTURE; STRESS AB A method that uses induced eddy current for characterization of niobium, tantalum and chromium sputtered coating on steel is presented in this paper. The objective of this work is to find the correlation between the sputtering conditions and resistivity of coatings and to develop a system for fast inspection of coatings as a coating quality control tool during production as well as in the field for determining coating degradation levels. A two-probe differential system having higher sensitivity and less noise than a one-probe system with 2D scanning ability was developed. A computer program that controls an XY table and performs fast data acquisition was written. Resistivity maps of the niobium, tantalum and chromium coated samples were constructed and are shown in the paper. For niobium coatings, the relationship between sputtering pressure and resistivity of coatings is examined, as well as the relationship between impurity level of process gas and resistivity of coatings. For tantalum coatings, the relationship between beta-Ta fraction and resistivity is analyzed. For chromium coatings, the relationship between micro-crack density and resistivity of coatings is analyzed. The topographic picture and destructive analysis of the samples show very good correlation with eddy currents measurements. (c) 2005 Elsevier B.V. All rights reserved. C1 Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. USA, Benet Labs, AMSTA, AR,CCB,TB, Watervliet Arsenal, NY 12189 USA. RP Lee, C (reprint author), Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. EM cqlee2182@yahoo.com RI Danon, Yaron/B-5159-2009 NR 15 TC 7 Z9 7 U1 3 U2 6 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD DEC 21 PY 2005 VL 200 IS 7 BP 2547 EP 2556 DI 10.1016/j.surfcoat.2004.12.033 PG 10 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 995JO UT WOS:000234096800070 ER PT J AU Mashatt, M Lewis, S AF Mashatt, M Lewis, S TI Oil reconstruction in Iraq: Progress and challenges SO OIL & GAS JOURNAL LA English DT Article C1 USA, Dept Def, Iraq Project & Contracting Off, Washington, DC 20310 USA. RP Mashatt, M (reprint author), USA, Dept Def, Iraq Project & Contracting Off, Washington, DC 20310 USA. NR 0 TC 0 Z9 1 U1 0 U2 1 PU PENNWELL PUBL CO ENERGY GROUP PI TULSA PA 1421 S SHERIDAN RD PO BOX 1260, TULSA, OK 74112 USA SN 0030-1388 J9 OIL GAS J JI Oil Gas J. PD DEC 19 PY 2005 VL 103 IS 47 BP 26 EP + PG 6 WC Energy & Fuels; Engineering, Petroleum SC Energy & Fuels; Engineering GA 997RS UT WOS:000234265700005 ER PT J AU Chilukuri, N Parikh, K Sun, W Naik, R Tipparaju, P Doctor, BR Saxena, A AF Chilukuri, N Parikh, K Sun, W Naik, R Tipparaju, P Doctor, BR Saxena, A TI Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE organophosphorus compounds; butyrylcholinesterase; adenoviral vectors; polyethylene glycosylation; gene therapy ID QUATERNARY ASSOCIATIONS; CHEMICAL MODIFICATION; COLLAGEN TAIL; ACETYLCHOLINESTERASE; TOXICITY; PROTECTION; SOMAN; CHOLINESTERASE; PRETREATMENT; DOMAINS AB Previous studies in rodents and non-human primates have demonstrated that pretreatment of animals with cholinesterases could provide significant protection against organophosphate (OP) nerve agent toxicity. Gene delivery/therapy is emerging as an approach to achieve high-level expression of proteins in vivo that are very similar to their native counterparts. Recently, adenoviral (Ad) vectors have proven to be excellent vehicles for delivering genes to cells in vitro and in vivo. In this study, we explored the use of the newly designed AdenoVATOR system for the expression of recombinant human butyrylcholinesterase (rHu BChE) in human embryonic kidney 293A (HEK-293A) cells. In these cells, rHu BChE was expressed as mostly tetrameric form by the simultaneous expression of proline-rich attachment domain. By optimizing the culture conditions, 1.5-2.0 U/ml of rHu BChE could be expressed in HEK-293A cells. Recombinant Hu BChE was purified to homogeneity by ammonium sulfate fractionation followed by affinity column chromatography using procainamide Sepharose and cobalt Sepharose gels. The enzymatic and physico-chemical properties of purified rHu BChE were similar to those of native serum-derived Hu ME. To determine the suitability of this preparation for use as an antidote against highly toxic nerve agents, its pharmacokinetics were evaluated in mice. Recombinant Hu BChE exhibited a mean residence time of 18.3 h which was 2.5-fold shorter than that observed for native Hu BChE in mice. However, rHu BChE chemically modified with polyethyleneglycol (PEG) displayed a mean residence time of 36.2 h suggesting that PEG-modification can prolong the circulatory stability of rHu BChE. The efficacy of Ad-Hu BChE to induce the production of therapeutic levels of bioscavenger in vivo is under evaluation. Published by Elsevier Ireland Ltd. C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Chilukuri, N (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nageswararao.chilukuri@na.amedd.army.mil NR 21 TC 26 Z9 27 U1 1 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI BP 115 EP 121 DI 10.1016/j.cbi.2005.10.013 PG 7 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000016 PM 16253215 ER PT J AU Doctor, BP Saxena, A AF Doctor, BP Saxena, A TI Bioscavengers for the protection of humans against organophosphate toxicity SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE butyrylcholinesterase; bioscavengers; organophosphorus compound toxicity; efficacy ID HUMAN-SERUM CHOLINESTERASE; HUMAN BUTYRYLCHOLINESTERASE; NERVE AGENTS; SOMAN; PRETREATMENT; PROPHYLAXIS; ANTIDOTE; MONKEYS AB Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetyleholinesterase (AChE) front irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. These antidotes are effective in preventing lethality from OP poisoning, but they do not prevent post-exposure incapacitation, convulsions, seizures, performance decrements, or in many cases permanent brain damage. These symptoms are commonly observed in experimental animals and are likely to occur in humans. The problems intrinsic to these antidotes stimulated attempts to develop a single protective drug, itself devoid of pharmacological effects, which would provide protection against the lethality of OP compounds and prevent post-exposure incapacitation. One approach is the use of enzymes such as cholinesterases (ChEs), P-esterases in general, as single pretreatment drugs to sequester highly toxic OP anti-ChEs before the reach their physiological targets. This approach turns the irreversible nature of the OP: ChE y interaction from disadvantage to an advantage; instead of focusing on OP as an anti-ChE, one can use ChE as an anti-OP. Using this approach, it was shown that administration of fetal bovine serum AChE (FBSAChE) or equine serum butyrylcholinesterase (EqBChE) or human serum BChE (HuBChE) protected the animals from multiple LD(50)s of a variety of highly toxic OPs without any toxic effects or performance decrements. The bioscavengers that have been explored to date for the detoxification of OPs fall into three categories: (A) those that can catalytically hydrolyze OPs and thus render them non-toxic, such as OP hydrolase and OP anhydrase; (B) those that stoichiometrically bind to OPs. that is, 1 mol of enzyme neutralizes one or 2 mol of OP inactivating both, such as ChEs and related enzymes; and (C) and those generally termed as "pseudo catalytic", e.g., a combination of ChE and an oxime pre-treatment such that the catalytic activity of OP-inhibited ChE can rapidly and continuously be restored in the presence of an oxime. Since the biochemical mechanism underlying prophylaxis by exogenous esterases such as ChEs is established and tested in several animal species, including non-human primates, this concept should allow a reliable extrapolation of results from animal experiments to human application. Having being extensively investigated by several groups, plasma derived HuBChE is judged to be the most suitable bioscavenger for its advancement for human use. The program is being developed at the present time for conducting a safety clinical trial in human volunteers. Several other candidate bioscavengers will follow; e.g., recombinant HuBChE expressed in the milk of transgenic goats, pseudo catalytic scavenger(s), e.g., a combination of ChE and oxime, and possibly PON 1 as a catalytic scavenger in the future. (c) 2005 Elsevier Ireland Ltd. All rights reserved. C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Doctor, BP (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM Bhupendra.Doctor@US.army.mil NR 18 TC 109 Z9 112 U1 3 U2 25 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI BP 167 EP 171 DI 10.1016/j.cbi.2005.10.024 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000022 PM 16293236 ER PT J AU Saxena, A Sun, W Luo, CY Doctor, BP AF Saxena, A Sun, W Luo, CY Doctor, BP TI Human serum butyrylcholinesterase: In vitro and in vivo stability, pharmacokinetics, and safety in mice SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE organophosphorus compounds; human serum butyrylcholinesterase; bioseavenger; pharmacokinetics; safety ID NERVE AGENTS; TOXICITY; SOMAN; PRETREATMENT; PROTECTION; ANTIDOTE AB The use of exogenously administered cholinesterases (ChEs) as bioscavengers of highly toxic organophosphate (OP) nerve agents is now sufficiently well documented to make them a highly viable prophylactic treatment against this potential threat. Of the ChEs evaluated so far, human serum butyrylcholinesterase (HuBChE) is most suitable for human use. A dose of 200 mg (3 mg/kg) of HuBChE is envisioned as a prophylactic treatment in humans that can protect from an exposure of up to 2 x LD50 of soman. In addition to its use as a prophylactic for a variety of wartime scenarios, including covert actions, it also has potential use for first responders (civilians) reacting to terrorist nerve gas release. We recently, developed a procedure for the large-scale purification of HuBChE, which yielded approximately 6 g of highly purified enzyme from 120 kg of Cohn fraction IV-4. The enzyme had a specific activity of 700-750 U/mg and migrated as a single band on SDS-PAGE. To provide data for initiating an investigational new drug (IND) application for the use of this enzyme as a bioscavenger in humans, we established its pharmacokinetic properties, examined its safety in mice, and evaluated its shelf life at various temperatures. In mice administered various doses up to 90 mg/kg, enzyme activity reached peak levels in circulation at 10 and 24 h following i.p. and i.m. injections, respectively. The enzyme displayed a mean residence time (MRT) of 40-50 h, regardless of the route of administration or dose of injected enzyme. Mice were euthanized 2 weeks following enzyme administration and tissues were examined grossly or microscopically for possible toxic effects. Results suggest that HuBChE does not exhibit any toxicity in mice as measured by general observation, serum chemistry, hematology, gross or histologic tissue changes. The shelf life of this enzyme stored at 4, 25, 37, and 45 degrees C was determined in lyophilized form. The enzyme was found to be stable when stored in lyophilized form at -20, 4, 25, or 37 degrees C to date (2 years), as measured by specific activity and SDS polyacrylamide gel electrophoresis. The effect of storage on circulatory stability was determined by measuring MRT in mice; there was no change in the MRT of lyophilized enzyme stored at -20 degrees C to date (2 years). These results provide convincing data that HuBChE is a safe bioscavenger that can provide protection against all OP nerve agents. Efforts are now underway to prepare the required documentation for submission of an IND application to the United States Food and Drug Administration (USFDA). (c) 2005 Elsevier Ireland Ltd. All rights reserved. C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ashima.saxena@na.amedd.army.mil NR 10 TC 33 Z9 33 U1 0 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI BP 199 EP 203 DI 10.1016/j.cbi.2005.10.028 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000026 PM 16263104 ER PT J AU Lenz, DE Maxwell, DM Koplovitz, I Clark, CR Capacio, BR Cerasoli, DM Federko, JM Luo, CY Saxena, A Doctor, BP Olson, C AF Lenz, DE Maxwell, DM Koplovitz, I Clark, CR Capacio, BR Cerasoli, DM Federko, JM Luo, CY Saxena, A Doctor, BP Olson, C TI Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE butyrylcholinesterase; soman; VX; guinea pigs; cynomolgus monkey ID ACETYLCHOLINESTERASE; TOXOGONIN; TOXICITY; INVIVO AB Human butyrylcholinesterase (HuBuChE), purified from outdated human plasma, is being evaluated for efficacy against nerve agents in guinea pigs and cynomolgus monkeys. Previous studies in rodents and nonhuman primates demonstrated that pretreatment of animals with enzymes that can scavenge nerve agents could provide significant protection against behavioral and lethal effects of nerve agent intoxication. In preparation for evaluation of efficacy of HuBuChE prior to initiating an investigational new drug (IND) application, the pharmacokinetics of HuBuChE were evaluated in guinea pigs and in cynomolgus monkeys. HuBuChE was injected intramuscularly (i.m.) at two doses, and blood samples were taken to follow the time-course of HuBuChE in blood for up to 168 h after administration. In guinea pigs, the two doses of HuBuChE, 19.9 and 32.5 mg/kg, produced similar times of maximal blood concentration (T-max, of 26.0 and 26.8 h, respectively) and similar elimination half-times (t(1/2) of 64.6 and 75.5 h, respectively). Enzyme levels were still 10-fold over baseline at 72 h. Based on these data, guinea pigs were administered 150 mg/kg of enzyme i.m. and challenged at T-max . Soman or VX doses were approximately 1.5, 2.0 and 2.0 x LD50 administered subcutaneously (s.c.) in sequence at 90-120 min apart. None of the animals displayed signs of organophosphorus (OP) anti cholinesterase intoxication at any of the challenge levels, and all survived for the 14-day duration of the experiment. Similar experiments were carried out with cynomolgus monkeys to determine the pharmacokinetics of HuBuChE and its efficacy against soman. The complete survival of nearly all animals tested to date, coupled with the maximal blood concentration and half-life elimination profile obtained for HuBuChE after i.m. injection, provides strong support for the continued development of HuBuChE as a product to protect against nerve agents. (c) 2005 Elsevier Ireland Ltd. All rights reserved. C1 US Army Med Res Inst Chem Def, Pharmacol Div, Aberdeen Proving Ground, MD 21010 USA. US Army Med Res Inst Chem Def, Drug Assessment Div, Aberdeen Proving Ground, MD 21010 USA. Walter Reid Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. Battelle Mem Inst, Columbus, OH 43201 USA. RP Lenz, DE (reprint author), US Army Med Res Inst Chem Def, Pharmacol Div, 3100 Ricketts Pt Rd, Aberdeen Proving Ground, MD 21010 USA. EM david.lenz@amedd.army.mil NR 17 TC 79 Z9 87 U1 1 U2 11 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI BP 205 EP 210 DI 10.1016/j.cbi.2005.10.025 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000027 PM 16289064 ER PT J AU Gordon, RK Haigh, JR Garcia, GE Feaster, SR Riel, MA Lenz, DE Aisen, PS Doctor, BP AF Gordon, RK Haigh, JR Garcia, GE Feaster, SR Riel, MA Lenz, DE Aisen, PS Doctor, BP TI Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE acetylcholinesterase; butyrylcholinesterase; robotics; high-throughput screening; pyridostigmine bromide; huperzine A; soman ID DISEASE AB Cholinesterases (ChEs) are classified as acetylcholinesterase (AChE) and butyryleholinesterase (BChE) according to their substrate specificity and sensitivity to selected inhibitors. The activities of AChE in red blood cells (RBC-AChE) and BChE in serum can be used as potential biomarkers of suppressed and/or heightened activity in the central and peripheral nervous systems. Exposure to orgyanophosphate (OP) chemical warfare agents (CWAs), pesticides, anesthetics, and a variety of drugs such as cocaine, as well as some neurodegenerative and liver disease states, selectively reduces AChE or BChE activity. In humans, the toxicity of pesticides is well documented. Therefore, blood cholinesterase activity can be exploited as a tool for confirming exposure to these agents and possible treatments. Current assays for measurement of RBC-AChE and serum BChE require several labor-intensive processing steps, suffer from wide statistical variation, and there is no inter-laboratory conversion between methods. These methods, which determine only the serum BChE or RBC-AChE but not both, include the Ellman, radiometric, and Delta pH (modified Michel) methods. In contrast, the Walter Reed Army Institute of Research Whole Blood (WRAIR WB, US Patent #6,746,850) cholinesterase assay rapidly determines the activity of both AChE and BChE in unprocessed (uncentrifuged) whole blood, uses a minimally invasive blood sampling technique (e.g., blood from a finger prick), and is semi-automated for high-throughput using the Biomek 2000 robotic system. To date. the WRAIR whole blood assay was used to measure AChE and BChE activities in human blood from volunteers in FDA clinical trials. In the first FDA study, 24 human Subjects were given either 30 mg PB orally (n = 19) or placebo (n = 5). Blood samples were obtained pre-dosing and 2.5 +/- 5, 8, and 24 h post-dosing. The samples were analyzed for AChE and BChE activity using the WRAIR WB robotic system, and for PB concentration by HPLC. We found that maximal inhibition of AChE (26.2%) and concentration of PB (17.1 ng/mL) occurred at 2.5 h post-PB dosing. AChE activity returned to almost 100% of pre-dose values by 6 h. A dose-dependent linear correlation was found between the amount of PB measured in the blood and the inhibition of AChE. Following soman (GD) exposure, recovered AChE activity was similar to levels that were reversibly protected by the PB administration. Therefore, the WRAIR ChE WB data clearly supports the conclusion that PB is an effective pre-treatment drug for nerve agent exposure (GD). In the second FDA human study for the treatment of Alzheimer's disease, the WRAIR ChE WB assay was used to determine the RBC-AChE and serum BChE profile of healthy elderly volunteers receiving Huperzine A. Huperzine A is a plant-derived reversible and selective AChE inhibitor compared to BChE, and is a more potent inhibitor of AChE than PB. Huperzine A is available as a nutraceutical, a natural supplement reported to improve memory, and has a variety of neuroprotective effects. Individuals received an increasing dose regimen of huperzine A (final dose 200 mu g after 4 weeks), which produced more than 50% inhibition of RBC-AChE. Huperzine A was well tolerated by these patients at doses that sequestered more RBC-AChE than PB, and thus warrants further study as a prophylaxis for OP poisoning in addition to Alzheimer's therapy. Due to the documented use of OPs by terrorists and in warfare around the globe, Federal, State, and local authorities need a reliable, fast, inexpensive, and standard method for confirming such an assault in order to initiate appropriate containment, decontamination, and treatment measures. This assay is ideal for prescreening military personnel for atypical ChE activities that would preclude their deployment to areas of potential CWA exposure. The WRAIR WB ChE assay will fulfill the requirement for rapid and reliable monitoring of such exposure in military and civilian populations. (c) 2005 Elsevier Ireland Ltd. All rights reserved. C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. United States Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. Georgetown Univ, Ctr Med, Dept Neurol, Washington, DC 20007 USA. RP Gordon, RK (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grand Rd, Silver Spring, MD 20910 USA. EM Richard.Gordon@amedd.army.mil NR 17 TC 41 Z9 43 U1 1 U2 13 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI BP 239 EP 246 DI 10.1016/j.cbi.2005.10.031 PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000032 PM 16256090 ER PT J AU Shih, TM Kan, RK McDonough, JH AF Shih, TM Kan, RK McDonough, JH TI In vivo cholinesterase inhibitory specificity of organophosphorus nerve agents SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE nerve agents; organophosphorus compounds; acetylcholinesterase inhibitors; soman; sarin; VX; cholinesterase; brain; blood; tissues ID BLOOD-BRAIN-BARRIER; INDUCED SEIZURES; SOMAN; NEUROPATHOLOGY; MECHANISMS AB The purpose of this project was to determine and compare the time-related changes in blood, brain, and tissue acetylcholinesterase (AChE) activity during the first hour after exposure to six organophosphorus nerve agents (GA, GB, GD, GF, VR, and VX) in Hartley guinea pigs. Animals were pretreated with atropine methyl nitrate (1.0 mg/kg, i.m.) to minimize peripheral toxic effects 15 min before they were given a 1.0 x LD50 subcutaneous dose of a nerve agent. At 0, 5, 10, 15, 30, and 60 min after nerve agent, animals were humanely euthanized. Blood was collected and brain regions (brainstem, cortex, hippocampus, midbrain, cerebellum, striatum, and spinal cord) and peripheral tissues (diaphragm, skeletal muscle, and heart) were dissected and processed for AChE activity. All six nerve agents produced maximum inhibition of AChE in red blood cells between 5 and 10% of the control within 10 min after exposure. In whole blood, differential effects were observed among the agents: GB, GD, and GF produced more rapid and greater inhibition than did GA, VR, and VX. GF was the most rapid, producing a maximum inhibition to 5% of the control in 5 min, while VR and VX were slower reaching maximum inhibition to 30% of the control at 15 min. The enzyme activity in the majority of the brain regions was more markedly inhibited by the G-agents than by the V-agents. The G-agents caused rapid AChE inhibition, reaching maximum levels (20-30% of control) at 15 min and GA produced the most rapid effects. V-agents produced much slower and less AChE inhibition, reaching maximum (35-60% of control) at 30 min. In the diaphragm, VR, VX, and GD produced more rapid and greater AChE inhibition than other G-agents; GA produced the slowest and least inhibition. In the skeletal muscle, VX induced the most rapid and severe inhibition, while GA the least inhibition. In the heart, all agents produced very rapid inhibition, and GD produced the most severe inhibition of AChE activity. These observations suggest that G-agents and V-agents are tissue compartment specific in their ability to inhibit AChE activity. Published by Elsevier Ireland Ltd. C1 US Army Med Res Inst Chem Def, Pharmacol & Comparat Med Div, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), US Army Med Res Inst Chem Def, Pharmacol & Comparat Med Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil NR 21 TC 51 Z9 52 U1 0 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI BP 293 EP 303 DI 10.1016/j.cbi.2005.10.042 PG 11 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000040 PM 16256093 ER PT J AU Hurley, MM Balboa, A Lushington, GH Guo, JX AF Hurley, MM Balboa, A Lushington, GH Guo, JX TI Interactions of organophosphorus and related compounds with cholinesterases, a theoretical study SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE acetylcholinesterase; simulation; docking; quantum mechanics ID HUMAN ACETYLCHOLINESTERASE; ACTIVE-SITE; INHIBITORS AB Acetylcholinesterase (AChE) is an interesting research target not only because of its high enzyme catalytic rate but also because of the wide range of health effects resulting from its inhibition. This paper discusses results of a theoretical study of acetylcholinesterase inhibition using several simulation techniques. In the first technique, a novel method was developed and used for predicting the binding affinity of human AChE (huAChE) inhibitors. Results are also presented for classical molecular dynamics and quantum mechanical simulations. Theoretical proton NMR shift results are obtained and compared to experiment, and the importance of the Glu199 residue is discussed in the context of the model. (c) 2005 Elsevier Ireland Ltd. All rights reserved. C1 US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. Univ Kansas, Lawrence, KS 66045 USA. RP Hurley, MM (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM hurley@arl.army.mil NR 13 TC 10 Z9 10 U1 0 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI BP 321 EP 325 DI 10.1016/j.cbi.2005.10.096 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000043 PM 16289061 ER PT J AU Haigh, JR Johnston, SR Peters, BM Doctor, BP Gordon, RK Adler, M Gall, KJ Deshpande, SS AF Haigh, JR Johnston, SR Peters, BM Doctor, BP Gordon, RK Adler, M Gall, KJ Deshpande, SS TI Inhibition of guinea pig hemi-diaphragm acetylcholinesterase activity by pyridostigmine bromide and protection against soman toxicity SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Meeting Abstract CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia C1 USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM julian.haigh@amedd.army.mil NR 1 TC 11 Z9 11 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI MA 19 BP 381 EP 382 DI 10.1016/j.cbi.2005.10.064 PG 2 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000069 PM 16429510 ER PT J AU Tonduli, LS Doctor, BP Saxena, A AF Tonduli, LS Doctor, BP Saxena, A TI An ex vivo approach for the evaluation of reversible inhibitors as potential pretreatments against organophosphate toxicity SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Meeting Abstract CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE organophosphorus compounds; acetylcholinesterase; blood AChE activity C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. EM laura.tonduli@na.amedd.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI MA 44 BP 426 EP 427 DI 10.1016/j.cbi.2005.10.089 PG 2 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000094 PM 16429574 ER PT J AU Wei, S Doctor, BP Saxena, A AF Wei, S Doctor, BP Saxena, A TI Safety and pharmacokinetics of human serum butyrylcholinesterase in guinea pigs SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Meeting Abstract CT 8th International Meeting on Cholinesterases CY SEP 26-30, 2004 CL Univ Perugia, Perugia, ITALY HO Univ Perugia DE organophosphorus compounds; human serum butyrylcholinesterase; guinea pigs; safety; pharmacokinetics ID TOXICITY C1 Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. EM wei.sun@na.amedd.army.mil NR 3 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD DEC 15 PY 2005 VL 157 SI SI MA 45 BP 428 EP 429 PG 2 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 998RN UT WOS:000234337000095 ER PT J AU Mita, AC de Jonge, M Verweij, J Papadopoulos, K Schwartz, G Mita, MM Ricart, A Wood, L Hamilton, M McCarthy, SP Iwata, K Rowinsky, EK AF Mita, AC de Jonge, M Verweij, J Papadopoulos, K Schwartz, G Mita, MM Ricart, A Wood, L Hamilton, M McCarthy, SP Iwata, K Rowinsky, EK TI Erlotinib (Tarceva@) "Dosing-to-Rash": Preliminary results of a pilot phase II intra-patient dose-escalation, pharmacokinetic (PK), and pharmacodynamic (PD) study of E in previously treated patients with advanced non-small cell lung cancer (NSCLC) SO CLINICAL CANCER RESEARCH LA English DT Meeting Abstract CT AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics CY NOV 14-18, 2005 CL Philadelphia, PA SP AACR, NCI, EORTC, AMGEN, AstraZeneca, Britol-Myers Squibb Co, Pfizer, Sanofi Aventis, Bayer Hlth Car Pharmaceut, Lilly, Genentech, GSK GlaxoSmithKline, Johnson &Johnson, MERCK, NOVARTIS ONCOL, Centocor, OSI Oncol, Schering-Plough, BTG, Servier, RADPHARM, Cvitkovic & Associes C1 CRC, Inst Drug Dev, San Antonio, TX USA. Erasmus Med Ctr, Rotterdam, Netherlands. Brooke Army Med Ctr, San Antonio, TX USA. OSI Pharmaceut Inc, Boulder, CO USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD DEC 15 PY 2005 VL 11 IS 24 SU S BP 9061S EP 9061S PN 2 PG 1 WC Oncology SC Oncology GA 999IJ UT WOS:000234382700391 ER PT J AU Papadopoulos, K Mendelson, D Preston, GG Lopez, AM Ricart, AD Schwartz, G Needle, MN Gordon, MS AF Papadopoulos, K Mendelson, D Preston, GG Lopez, AM Ricart, AD Schwartz, G Needle, MN Gordon, MS TI A phase I study of lenalidomide and weekly docetaxel in patients with advanced solid tumors. SO CLINICAL CANCER RESEARCH LA English DT Meeting Abstract CT AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics CY NOV 14-18, 2005 CL Philadelphia, PA SP AACR, NCI, EORTC, AMGEN, AstraZeneca, Britol-Myers Squibb Co, Pfizer, Sanofi Aventis, Bayer Hlth Car Pharmaceut, Lilly, Genentech, GSK GlaxoSmithKline, Johnson &Johnson, MERCK, NOVARTIS ONCOL, Centocor, OSI Oncol, Schering-Plough, BTG, Servier, RADPHARM, Cvitkovic & Associes C1 Inst Drug Dev, San Antonio, TX USA. Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA. Arizona Canc Ctr, Scottsdale, AZ USA. Brooke Army Med Ctr, San Antonio, TX USA. Celgene, Summit, NJ USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD DEC 15 PY 2005 VL 11 IS 24 SU S BP 9116S EP 9116S PN 2 PG 1 WC Oncology SC Oncology GA 999IJ UT WOS:000234382701192 ER PT J AU Nalca, A Rimoin, AW Bavari, S Whitehouse, CA AF Nalca, A Rimoin, AW Bavari, S Whitehouse, CA TI Reemergence of monkeypox: Prevalence, diagnostics, and countermeasures SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID VIRUS RESPIRATORY-INFECTIONS; POXVIRUS INFECTIONS; VACCINIA; CIDOFOVIR; MICE; TRANSMISSION; SMALLPOX; COWPOX; ORTHOPOXVIRUSES; IDENTIFICATION AB Human monkeypox is a viral zoonotic disease that occurs mostly in the rain forests of central and western Africa. However, the disease recently emerged in the United States in imported wild rodents from Africa. Monkeypox has a clinical presentation very similar to that of ordinary forms of smallpox, including flulike symptoms, fever, malaise, back pain, headache, and characteristic rash. Given this clinical spectrum, differential diagnosis to rule out smallpox is very important. There are no licensed therapies for human monkeypox; however, the smallpox vaccine can protect against the disease. The discontinuation of general vaccination in the 1980s has given rise to increasing susceptibility to monkeypox virus infection in the human population. This has led to fears that monkeypox virus could be used as a bioterrorism agent. Effective prevention relies on limiting the contact with infected patients or animals and limiting the respiratory exposure to infected patients. C1 USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA. RP Nalca, A (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM aysegul.nalca@amedd.army.mil NR 45 TC 54 Z9 58 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 15 PY 2005 VL 41 IS 12 BP 1765 EP 1771 DI 10.1086/498155 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 989UB UT WOS:000233698300014 PM 16288402 ER PT J AU Jenkins, RA Thapinta, D Morgan, PA Wongkamhaeng, S Sornsathapornkul, P Bussaratid, V Sontirat, A Pitisuttithum, P Thongchareoen, P Khamboonruang, C Suriyanon, V Nitayaphan, S Brown, AE AF Jenkins, RA Thapinta, D Morgan, PA Wongkamhaeng, S Sornsathapornkul, P Bussaratid, V Sontirat, A Pitisuttithum, P Thongchareoen, P Khamboonruang, C Suriyanon, V Nitayaphan, S Brown, AE CA Thai AIDS Vaccine Evaluation Grp TI Behavioral and social issues among volunteers in a preventive HIV vaccine trial in Thailand SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV vaccine trials; HIV sexual risk behavior; Thailand ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUALLY-TRANSMITTED-DISEASES; NORTHERN THAILAND; RISK BEHAVIOR; DRUG-USE; PHASE-I; MEN; PARTICIPATE; INFECTION; WILLINGNESS AB Behavioral and social issues were investigated in 363 phase I/II preventive HIV-1 vaccine trial Volunteers in Thailand. These issues included risk behavior, HIV knowledge, distress, and social consequences of vaccine trial participation. Data were collected at baseline and at 4-, 8-, and 12-month follow-Lip visits. Volunteers reported relatively low levels of risk behaviors at baseline and at follow-up. Overtly negative reactions from family or friends were reported by 5.9%. No experiences of discrimination in employment, health care, or insurance were reported. Mean levels of distress were low throughout the trial, and HIV-related knowledge was high, although it was common to consider the possibility of HIV transmission through casual contact. Findings add to the evidence that preventive HIV vaccine trials are feasible in Thailand. C1 Ctr Dis Control & Prevent, Div HIV, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Div AIDS Prevent, Atlanta, GA 30333 USA. Henry M Jackson Fdn, Rockville, MD USA. USA Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. Chiang Mai Univ, Fac Nursing, Chiang Mai 50000, Thailand. Res Inst Hlth Sci, Chiang Mai, Thailand. Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10700, Thailand. Mahidol Univ, Fac Trop Med, Vaccine Trial Ctr, Bangkok 10700, Thailand. Chiang Mai Univ, Fac Med, Chiang Mai 50000, Thailand. Armed Forces Res Inst Med Sci, Royal Thai Army Component, Bangkok 10400, Thailand. RP Jenkins, RA (reprint author), Ctr Dis Control & Prevent, Div HIV, 1600 Clifton Rd NE,Mailstop E-37, Atlanta, GA 30333 USA. EM rgj2@cdc.gov NR 40 TC 15 Z9 16 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD DEC 15 PY 2005 VL 40 IS 5 BP 592 EP 599 DI 10.1097/01.qai.0000171725.09812.a5 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 989SR UT WOS:000233694600014 PM 16284537 ER PT J AU Dacunha, JJ AF Dacunha, JJ TI Transition matrix and generalized matrix exponential via the Peano-Baker series SO JOURNAL OF DIFFERENCE EQUATIONS AND APPLICATIONS LA English DT Article DE Peano-Baker series; time scale; matrix exponential; transition matrix; Laplace transformation ID TIME SCALES AB We give a closed form for the unique solution to the n x n regressive time varying linear dynamic system of the form x(Delta)(t) = A(t)x(t), x(t(0)) = x(0), via use of a newly developed generalized form of the Peano-Baker series. We develop a power series representation for the generalized time scale matrix exponential when the matrix A(t) equivalent to A is a constant matrix. We also introduce a finite series representation of the matrix exponential using the Laplace transform for time scales, as well as a theorem which allows us to write the matrix exponential as a series of (n - 1) terms of scalar C-rd(infinity)(T, R) functions multiplied by powers of the system matrix A. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Dacunha, JJ (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM jeffrey_dacunha@yahoo.com NR 10 TC 26 Z9 29 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1023-6198 J9 J DIFFER EQU APPL JI J. Differ. Equ. Appl. PD DEC 15 PY 2005 VL 11 IS 15 BP 1245 EP 1264 DI 10.1080/10236190500272798 PG 20 WC Mathematics, Applied SC Mathematics GA 999YN UT WOS:000234428200002 ER PT J AU Opal, SM Palardy, JE Chen, WH Parejo, NA Bhattacharjee, AK Cross, AS AF Opal, SM Palardy, JE Chen, WH Parejo, NA Bhattacharjee, AK Cross, AS TI Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: Its use with CpG adjuvant and potential mechanisms SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID COMPLEX VACCINE; BACTERIAL-DNA; PHASE-I; LIPOPOLYSACCHARIDE; OLIGODEOXYNUCLEOTIDES; POLYSACCHARIDE; SAFETY; MICE; IMMUNOGENICITY; ANTIBODIES AB Background. An experimental vaccine for sepsis, composed of detoxified Escherichia coli J5 lipopolysaccharide (LPS) complexed with the outer membrane protein (OMP) of Neisseria meningitidis group B, induces anti-core glycolipid antibody and has been tested in pilot studies in human volunteers. Methods. Mice were immunized with the LPS-J5/OMP vaccine with or without synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs as a vaccine adjuvant (CpG ODN). The efficacy of the vaccine-induced antibody response was tested in a cecal ligation and puncture model. Results. Immunization resulted in a > 20-fold increase in anti-core glycolipid antibody levels, which were further increased 5-fold by the addition of CpG ODN, compared with the levels in mice in the control group. The vaccine provided a survival advantage after a cecal ligation and puncture was performed (P <.01) and significantly decreased the levels of bacteria in organs. Immunoglobulin G (IgG) anti-core glycolipid antibodies were decreased in mice to a significantly greater extent than were levels of total circulating IgG or IgG to the OMP part of the vaccine complex, suggesting specific epitope binding and clearance. Conclusions. These results indicate that the detoxified LPS-J5/OMP vaccine induces high levels of antibody against the core glycolipid of LPS and functions in vivo to promote clearance of gram-negative bacteria and improve the outcome of experimental polymicrobial intra-abdominal sepsis. C1 Brown Med Sch, Div Infect Dis, Providence, RI USA. Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. Walter Reed Army Inst Res, Washington, DC USA. RP Opal, SM (reprint author), Mem Hosp Rhode Isl, Div Infect Dis, 111 Brewster St, Pawtucket, RI 02860 USA. EM Steven_Opal@brown.edu FU NIAID NIH HHS [AI-42181] NR 22 TC 16 Z9 16 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2005 VL 192 IS 12 BP 2074 EP 2080 DI 10.1086/498167 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 984QK UT WOS:000233319200008 PM 16288370 ER PT J AU Pablo, K Rooks, P Nevin, R AF Pablo, K Rooks, P Nevin, R TI Benefits of serologic screening for hepatitis B immunity in military recruits SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter C1 USA, Army Med Surveillance Act, Ctr Hlth Promot & Prevent Med, Washington, DC 20307 USA. Gen Leonard Wood Army Community Hosp, Ft Leonard Wood, MO USA. RP Nevin, R (reprint author), USA, Army Med Surveillance Act, Ctr Hlth Promot & Prevent Med, Bldg T-20,Room 213,6900 Georgia Ave NW, Washington, DC 20307 USA. EM remington.nevin@us.army.mil NR 5 TC 6 Z9 6 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2005 VL 192 IS 12 BP 2180 EP 2181 DI 10.1086/498045 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 984QK UT WOS:000233319200024 PM 16288386 ER PT J AU Niebuhr, DW Scott, PT Gaydos, JC AF Niebuhr, DW Scott, PT Gaydos, JC TI Benefits of serologic screening for hepatitis B immunity in military recruits - Reply to Pablo et al. SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter C1 Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.niebuhr@na.amedd.army.mil RI Niebuhr, David/B-7865-2011 NR 4 TC 1 Z9 1 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 15 PY 2005 VL 192 IS 12 BP 2181 EP 2181 DI 10.1086/498046 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 984QK UT WOS:000233319200025 ER PT J AU Fang, SF Gertner, GZ Sun, ZL Anderson, AA AF Fang, SF Gertner, GZ Sun, ZL Anderson, AA TI The impact of interactions in spatial simulation of the dynamics of urban sprawl SO LANDSCAPE AND URBAN PLANNING LA English DT Article DE cellular automata model; interactions; land use; logistic regression; spatial simulation; system dynamics; urban sprawl ID LAND-USE CHANGE; CELLULAR-AUTOMATA; COVER CHANGE; COSTA-RICA; MODEL; MASSACHUSETTS; UNCERTAINTY; VALIDATION; SCENARIOS; PATTERN AB This study investigated the modeling process for simulating the spatial dynamics of an urban ecosystem. Logistic regression is a common method for empirically modeling and analyzing land use and land use change. In most conventional applications of logistic regression, only the individual factors of the system are considered in the development of the logistic regression functions. However, this does not consider the relationships among factors that potentially occur within most ecosystems. Factors in a system, especially an urban system, are usually not fixed and not independent of each other, but rather are influenced by each other. Based on this point of view, the interactions of factors are introduced into a logistic regression in this study. This technique has been tested with a case study using historical land use maps and a spatially explicit dynamic cellular automata urban sprawl model. Using historical land use data, a logistic regression was used to analytically weight the scores of the driving factors of an urban sprawl model for predicting probability maps of land use change. The results of the case study have verified that interactions of factors can significantly improve the prediction of spatial dynamics of urban sprawl, and can provide a means to improve cellular automata models for simulation of the dynamics of urban and other ecosystems. (c) 2004 Elsevier B.V. All rights reserved. C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. Univ Illinois, Dept Urban & Reg Planning, Champaign, IL 61820 USA. USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61824 USA. RP Gertner, GZ (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, W503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@uiuc.edu OI Sun, Zhanli/0000-0001-6204-4533 NR 47 TC 67 Z9 84 U1 2 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-2046 J9 LANDSCAPE URBAN PLAN JI Landsc. Urban Plan. PD DEC 15 PY 2005 VL 73 IS 4 BP 294 EP 306 DI 10.1016/j.landurbplan.2004.08.006 PG 13 WC Ecology; Environmental Studies; Geography; Geography, Physical; Urban Studies SC Environmental Sciences & Ecology; Geography; Physical Geography; Urban Studies GA 977RZ UT WOS:000232822200003 ER PT J AU Szebeni, J AF Szebeni, J TI Complement activation-related pseudoallergy: A new class of drug-induced acute immune toxicity SO TOXICOLOGY LA English DT Review DE allergy; anaphylatoxins; anaphylactoid reaction; micelles; radiocontrast agents; cancer chemotherapy; taxol; Cremophor EL ID LIPOSOME-ENCAPSULATED HEMOGLOBIN; HYPERSENSITIVITY REACTIONS; CREMOPHOR-EL; IN-VITRO; RADIOCONTRAST MEDIA; CONTRAST-MEDIA; PHASE-II; CLINICAL PHARMACOKINETICS; POLYETHYLENE-GLYCOL; HISTAMINE-RELEASE AB A major goal in modem pharmacotechnology is to increase the therapeutic index of drugs by using nanoparticulate vehicle systems in order to ensure slow release or targeted delivery of drugs. With all great benefits, however, these innovative therapies can carry a risk for acute immune toxicity manifested in hypersensitivity reactions (HSRs) that do not involve IgE but arises as a consequence of activation of the complement (C) system. These anaphylactoid reactions can be distinguished within the Type I category of HSRs as "C activation-related pseudoallergy" (CARPA). Drugs and agents causing CARPA include radiocontrast media (RCM), liposomal drugs (Doxil, Ambisome and DaunoXome) and micellar solvents containing amphiphilic lipids (e.g., Cremophor EL, the vehicle of Taxol). These agents activate C through both the classical and the alternative pathways, giving rise to C3a and C5a anaphylatoxins that trigger mast cells and basophils for secretory response that underlies HSRs. Pigs provide a useful model for liposome-induced CARPA as minute amounts of reactogenic lipomes cause C activation with consequent dramatic cardiovascular and laboratory abnormalities that mimic some of the human symptoms. Consistent with the causal role of C activation in liposome-induced HSRs, a recent clinical study demonstrated correlation between the formation of C terminal complex (SC5b-9) in blood and the presence of HSRs in patients treated with liposomal doxorubicin (Doxil). Overall, the CARPA concept may help in the prediction, prevention and treatment of the acute immune toxicity of numerous state-of-the-art drugs. (c) 2005 Published by Elsevier Ireland Ltd. C1 Semmelweis Univ, Fac Med, Inst Pathophysiol, Nephrol Res Grp, H-1089 Budapest, Hungary. Walter Reed Army Inst Res, Dept Vaccine Prod & Delivery, Div Retrovirol, Silver Spring, MD USA. Henry Jackson Fdn Mil Med Res, Silver Spring, MD USA. RP Szebeni, J (reprint author), Semmelweis Univ, Fac Med, Inst Pathophysiol, Nephrol Res Grp, Nagyvarad Ter 4, H-1089 Budapest, Hungary. EM jszebeni@hivresearch.org NR 122 TC 233 Z9 260 U1 6 U2 36 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD DEC 15 PY 2005 VL 216 IS 2-3 BP 106 EP 121 DI 10.1016/j.tox.2005.07.023 PG 16 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 996SH UT WOS:000234194400002 PM 16140450 ER PT J AU Zhou, X Tamma, KK Sha, D AF Zhou, X Tamma, KK Sha, D TI Design spaces, measures and metrics for evaluating quality of time operators and consequences leading to improved algorithms by design - illustration to structural dynamics SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article DE time discretized operators; computational algorithms by design; structural dynamics; design spaces and algorithmic measures ID UNCONDITIONALLY STABLE IMPLICIT; IMPROVED NUMERICAL DISSIPATION; COMPUTATIONAL DYNAMICS; INTEGRAL METHODOLOGY; EXPLICIT REPRESENTATIONS; DISCRETIZED OPERATORS; GENERALIZED FAMILY; THEORETICAL DESIGN; ARBITRARY ORDER; NEW-GENERATION AB For the first time, for time discretized operators, we describe and articulate the importance and notion of design spaces and algorithmic measures that not only can provide new avenues for improved algorithms by design, but also can distinguish in general, the quality of computational algorithms for time-dependent problems; the particular emphasis is on structural dynamics applications for the purpose of illustration and demonstration of the basic concepts (the underlying concepts can be extended to other disciplines as well). For further developments in time discretized operators and/or for evaluating existing methods, from the established measures for computational algorithms, the conclusion that the most effective (in the sense of convergence, namely, the stability and accuracy, and complexity, namely, the algorithmic formulation and algorithmic structure) computational algorithm should appear in a certain algorithmic structure of the design space amongst comparable algorithms is drawn. With this conclusion, and also with the notion of providing new avenues leading to improved algorithms by design, as an illustration, a novel computational algorithm which departs from the traditional paradigm (in the sense of LMS methods with which we are mostly familiar with and widely used in commercial software) is particularly designed into the perspective design space representation of comparable algorithms, and is termed here as the forward displacement non-linearly explicit L-stable (FDEL) algorithm which is unconditionally consistent and does not require non-linear iterations within each time step. From the established measures for comparable algorithms, simply for illustration purposes, the resulting design of the FDEL formulation is then compared with the commonly advocated explicit central difference method and the implicit Newmark average acceleration method (alternately, the same conclusion holds true against controllable numerically dissipative al gorithms) which pertain to the class of linear multi-step (LMS) methods for assessing both linear and non-linear dynamic cases. The conclusions that the proposed new design of the FDEL algorithm which is a direct consequence of the present notion of design spaces and measures, is the most effective algorithm to-date to our knowledge in comparison to the class of second-order accurate algorithms pertaining to LMS methods for routine and general non-linear dynamic situations is finally drawn through rigorous numerical experiments. Copyright (c) 2005 John Wiley & Sons, Ltd. C1 Univ Minnesota, Dept Mech Engn, Army High Performance Comp Res Ctr, Minneapolis, MN 55414 USA. RP Tamma, KK (reprint author), Univ Minnesota, Dept Mech Engn, Army High Performance Comp Res Ctr, 111 Church St SE, Minneapolis, MN 55414 USA. EM xiangmin@msi.umn.edu; ktamma@tc.umn.edu; sha@msi.umn.edu NR 40 TC 10 Z9 10 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD DEC 14 PY 2005 VL 64 IS 14 BP 1841 EP 1870 DI 10.1002/nme.1405 PG 30 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 992IJ UT WOS:000233877300001 ER PT J AU O'Malley, PG Khandekar, JD Phillips, RA AF O'Malley, PG Khandekar, JD Phillips, RA TI Residency training in the modern era - The pipe dream of less time to learn more, care better, and be more professional SO ARCHIVES OF INTERNAL MEDICINE LA English DT Editorial Material ID WORK HOURS; PATIENT SAFETY; GAP C1 Walter Reed Army Med Ctr, Div Gen Internal Med, Washington, DC 20307 USA. RP O'Malley, PG (reprint author), Walter Reed Army Med Ctr, Div Gen Internal Med, 6900 Georgia Ave, Washington, DC 20307 USA. EM patrick.omalley@na.amedd.army.mil NR 12 TC 11 Z9 11 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD DEC 12 PY 2005 VL 165 IS 22 BP 2561 EP 2562 DI 10.1001/archinte.165.22.2561 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 992KW UT WOS:000233883800002 PM 16344409 ER PT J AU Roesel, TR AF Roesel, TR TI Dengue in travelers SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID SURVEILLANCE C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Roesel, TR (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM thomas.roesel@na.amedd.army.mil NR 4 TC 1 Z9 1 U1 0 U2 0 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 8 PY 2005 VL 353 IS 23 BP 2512 EP 2512 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 990OZ UT WOS:000233754400020 ER PT J AU Kim, HS Schell, MA Yu, Y Ulrich, RL Sarria, SH Nierman, WC DeShazer, D AF Kim, HS Schell, MA Yu, Y Ulrich, RL Sarria, SH Nierman, WC DeShazer, D TI Bacterial genome adaptation to niches: Divergence of the potential virulence genes in three Burkholderia species of different survival strategies SO BMC GENOMICS LA English DT Article ID PSEUDOMALLEI; IDENTIFICATION; MELIOIDOSIS; INFECTION; GLANDERS; PROTEINS; SEQUENCE; MALLEI; SYSTEM; AGENTS AB Background: Two closely related species Burkholderia mallei (Bm) and Burkholderia pseudomallei (Bp) are serious human health hazards and are potential bio-warfare agents, whereas another closely related species Burkholderia thailandensis (Bt) is a non-pathogenic saprophyte. To investigate the genomic factors resulting in such a dramatic difference, we first identified the Bm genes responsive to the mouse environment, and then examined the divergence of these genes in Bp and Bt. Results: The genes down-expressed, which largely encode cell growth-related proteins, are conserved well in all three species, whereas those up-expressed, which include potential virulence genes, are less well conserved or absent notably in Bt. However, a substantial number of up-expressed genes is still conserved in Bt. Bm and Bp further diverged from each other in a small number of genes resulting from unit number changes in simple sequence repeats (ssr) in the homologs. Conclusion: Our data suggest that divergent evolution of a small set of genes, rather than acquisition or loss of pathogenic islands, is associated with the development of different life styles in these bacteria of similar genomic contents. Further divergence between Bm and Bp mediated by ssr changes may reflect different adaptive processes of Bm and Bp fine-tuning into their host environments. C1 USA, Med Res Inst Infect Dis, Detrick, MD 21702 USA. Inst Genom Res, Rockville, MD 20850 USA. Univ Georgia, Dept Microbiol & Plant Pathol, Athens, GA 30602 USA. RP Nierman, WC (reprint author), USA, Med Res Inst Infect Dis, Detrick, MD 21702 USA. EM hkim@tigr.org; schell@uga.edu; yyu@tigr.org; UlrichRL@amedd.army.mil; ssarria@tigr.org; wnerman@tigr.org; david.deshazer@us.army.mil FU NIAID NIH HHS [U01AI49037A, R01 AI056006, R01AI50565, R01AI56006, R01 AI050565] NR 39 TC 91 Z9 514 U1 2 U2 24 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 7 PY 2005 VL 6 AR 174 DI 10.1186/1471-2164-6-174 PG 13 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 005YG UT WOS:000234861700001 PM 16336651 ER PT J AU Sejvar, JJ Labutta, RJ Chapman, LE Grabenstein, JD Iskander, J Lane, JM AF Sejvar, JJ Labutta, RJ Chapman, LE Grabenstein, JD Iskander, J Lane, JM TI Neurologic adverse events associated with smallpox vaccination in the United States, 2002-2004 SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID GUILLAIN-BARRE-SYNDROME; REPORTING SYSTEM; VACCINIA VIRUS; BELLS-PALSY; COMPLICATIONS; SURVEILLANCE; ENCEPHALITIS; IMMUNIZATION; EXPERIENCE; CHILDREN AB Context Neurologic illness is an infrequent but severe adverse event associated with smallpox vaccination. The reinstatement of smallpox vaccination in the United States in response to possible bioterrorism renewed concerns about vaccine-related adverse neurologic events. Objective To determine rates and describe the clinical features of neurologic events associated with smallpox vaccination. Design and Setting We assessed reports of adverse events obtained through active case reporting and review of data reported to the Vaccine Adverse Event Reporting System among 665 000 persons vaccinated against smallpox by the Departments of Defense (n = 590 400) and Health and Human Services (n =64 600) during the 20022004 US Smallpox Vaccination Program. Main Outcome Measure Adverse neurologic events temporally associated with smallpox vaccination. Results Between December 16, 2002, and March 11, 2004, 214 neurologic adverse events temporally associated with smallpox vaccination were reported; 111 reports involved Department of Health and Human Services and 103 involved Department of Defense vaccinees. Fifty-four percent of these events occurred within 1 week of vaccination, and 53% were among primary vaccinees. The most common neurologic adverse event was headache (95 cases), followed by nonserious limb paresthesias (n = 17) or pain (n = 13) and dizziness or vertigo (n = 13). Serious neurologic adverse events included 13 cases of suspected meningitis, 3 cases of suspected encephalitis or myelitis, 11 cases of Bell palsy, 8 seizures (including 1 death), and 3 cases of Guillain-Barre syndrome. Among these 39 events, 27 (69%) occurred in primary vaccinees and all but 2 occurred within 12 days of vaccination. Conclusions During the 2002-2004 smallpox vaccination campaign, reported neurologic events were generally mild and self-limited, and no neurologic syndrome was identified at a rate above baseline estimates. Serious neurologic adverse events, such as postvaccinal encephalitis, Bell palsy, and Guillain-Barre syndrome, occurred in accordance with expected ranges. C1 Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA. Ctr Dis Control & Prevent, Epidemiol & Surveillance Div, Natl Immunizat Program, Atlanta, GA 30333 USA. Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. USA Med Command, Mil Vaccine Agcy, Falls Church, VA USA. Ctr Dis Control & Prevent, Smallpox Eradicat Program, Atlanta, GA USA. RP Sejvar, JJ (reprint author), Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, 1600 Clifton Rd,Mailstop A-39, Atlanta, GA 30333 USA. EM zea3@cdc.gov NR 49 TC 40 Z9 43 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 7 PY 2005 VL 294 IS 21 BP 2744 EP 2750 DI 10.1001/jama.294.21.2744 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 990EV UT WOS:000233726900023 PM 16333010 ER PT J AU Duffy, PE Sibley, H AF Duffy, PE Sibley, H TI Are we losing artemisinin combination therapy already? SO LANCET LA English DT Editorial Material ID PLASMODIUM-FALCIPARUM; CHLOROQUINE RESISTANCE; MALARIA; ARTEMETHER; SERCA C1 Seattle Biomed Res Inst, Malaria Antigen Discovery Program, Seattle, WA 98109 USA. Walter Reed Army Inst Res, Seattle, WA 98109 USA. Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, Malaria Antigen Discovery Program, 4 Nickerson St, Seattle, WA 98109 USA. EM pduffy@sbri.org NR 13 TC 20 Z9 20 U1 0 U2 2 PU LANCET LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0140-6736 J9 LANCET JI Lancet PD DEC 3 PY 2005 VL 366 IS 9501 BP 1908 EP 1909 DI 10.1016/S0140-6736(05)67768-9 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 990XY UT WOS:000233777900006 PM 16325683 ER PT J AU Rachal, J Lacy, TJ Warner, CH Whelchel, J AF Rachal, J Lacy, TJ Warner, CH Whelchel, J TI Characteristics of combined family practice-psychiatry residency programs SO ACADEMIC PSYCHIATRY LA English DT Article ID PRIMARY-CARE; INTERNAL-MEDICINE; UNITED-STATES; DEPRESSION; DISORDERS; PRACTITIONERS; PERSPECTIVES; MANAGEMENT; PHYSICIANS; DIAGNOSIS AB Objective: To evaluate how family practice-psychiatry residency programs meet the challenges of rigorous accreditation demands, clinical supervision, and boundaries of practice. Method: A 54-question survey of program directors of family practice-psychiatry residency programs outlining program demographic data, curricula, coordination, resident characteristics, integration, and overall satisfaction was mailed to 11 combined family practice psychiatry-residency programs. Results: Programs surveyed were meeting residency review committee (RRC) requirements, and a majority of the program directors believe that the training is as good as or better than categorical programs, and categorical residents benefited from training alongside combined residents. Conclusions: Training programs are growing in size and producing quality physicians. C1 Div Mental Hlth, Ft Stewart, GA 31314 USA. Malcolm Grow Med Ctr, Dept Psychiat, Andrews AFB, MD USA. Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC USA. Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI USA. RP Warner, CH (reprint author), Div Mental Hlth, Bldg 601 E, Ft Stewart, GA 31314 USA. EM christopher.h.warner@us.army.mil NR 21 TC 7 Z9 7 U1 0 U2 3 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1042-9670 J9 ACAD PSYCHIATR JI Acad. Psych. PD DEC PY 2005 VL 29 IS 5 BP 419 EP 425 DI 10.1176/appi.ap.29.5.419 PG 7 WC Education & Educational Research; Psychiatry SC Education & Educational Research; Psychiatry GA 998EK UT WOS:000234301200003 PM 16387963 ER PT J AU Warner, CH Bobo, WV Flynn, J AF Warner, CH Bobo, WV Flynn, J TI Early career professional development issues for military academic psychiatrists SO ACADEMIC PSYCHIATRY LA English DT Article ID MENTORING PROGRAM; RESIDENT RESEARCH; MEDICINE; FACULTY AB Objective: Academically motivated graduates of military psychiatric residency programs confront serious challenges. Method: In this article, the authors present a junior faculty development model organized around four overlapping domains: mentorship, scholarship, research, and career planning/ development. Using these four domains as a platform for discussion, the authors focus on challenges facing academically oriented early-career military psychiatrists and provide guidance. Conclusion: The authors believe that a proactive stance, skillful mentoring, self-awareness through conscious planning and effort, ability to capitalize on existing opportunities for growth, and attention to detail are all vital to the junior military psychiatrist. C1 Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC USA. Malcolm Grow Med Ctr, Dept Psychiat, Andrews AFB, MD USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD USA. Wilford Hall USAF Med Ctr, Dept Psychiat, Lackland AFB, TX USA. RP Warner, CH (reprint author), Div Mental Hlth, Bldg 601 E, Ft Stewart, GA 31314 USA. EM christopher.h.warner@us.army.mil NR 28 TC 2 Z9 2 U1 1 U2 2 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1042-9670 J9 ACAD PSYCHIATR JI Acad. Psych. PD DEC PY 2005 VL 29 IS 5 BP 437 EP 442 DI 10.1176/appi.ap.29.5.437 PG 6 WC Education & Educational Research; Psychiatry SC Education & Educational Research; Psychiatry GA 998EK UT WOS:000234301200006 PM 16387966 ER PT J AU Huzij, TJ Warner, CH Lacy, T Rachal, J AF Huzij, TJ Warner, CH Lacy, T Rachal, J TI Teaching psychiatry to family practice residents SO ACADEMIC PSYCHIATRY LA English DT Article ID PRIMARY-CARE PHYSICIANS; GENERALIZED ANXIETY; EDUCATION; SKILLS AB Objective: This article outlines a psychiatry curriculum developed for family practice residents by family practice-psychiatry residents. Methods: A literature review, needs assessment, planning, implementation, and initial assessment were conducted. Conclusion: Early results demonstrated improved general psychiatric knowledge and a high level of satisfaction. C1 Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC USA. Malcolm Grow Med Ctr, Dept Psychiat, Andrews AFB, MD USA. Ehrling Berquist Hosp, Dept Psychiat, Offutt AFB, NE USA. RP Warner, CH (reprint author), Div Mental Hlth, Bldg,601 E, Ft Stewart, GA 31314 USA. EM christopher.h.warner@us.army.mil NR 8 TC 1 Z9 1 U1 0 U2 2 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1042-9670 J9 ACAD PSYCHIATR JI Acad. Psych. PD DEC PY 2005 VL 29 IS 5 BP 479 EP 482 DI 10.1176/appi.ap.29.5.479 PG 4 WC Education & Educational Research; Psychiatry SC Education & Educational Research; Psychiatry GA 998EK UT WOS:000234301200014 PM 16387974 ER PT J AU Paonessa, D Napolitano, P Shields, A Howard, B Gotkin, J Deering, S Hoeldtke, N AF Paonessa, D Napolitano, P Shields, A Howard, B Gotkin, J Deering, S Hoeldtke, N TI The effect of cholic acid on placental artery perfusion pressure in the ex vivo placental cotyledon model SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 26th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY JAN 30-FEB 04, 2006 CL Miami Beach, FL SP Soc Maternal Fetal Med C1 Madigan Army Med Ctr, Tacoma, WA 98431 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2005 VL 193 IS 6 SU S MA 606 BP S173 EP S173 DI 10.1016/j.ajog.2005.10.693 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 993IM UT WOS:000233947800602 ER PT J AU Paonessa, D Shields, A Celver, J Howard, B Gotkin, J Deering, S Hoeldtke, N Napolitano, P AF Paonessa, D Shields, A Celver, J Howard, B Gotkin, J Deering, S Hoeldtke, N Napolitano, P TI 17-Hydroxyprogesterone caproate reverses thromboxane induced vasoconstriction of the fetoplacental arteries SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Meeting Abstract CT 26th Annual Meeting of the Society-for-Maternal-Fetal-Medicine CY JAN 30-FEB 04, 2006 CL Miami Beach, FL SP Soc Maternal Fetal Med C1 Madigan Army Med Ctr, Tacoma, WA 98431 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD DEC PY 2005 VL 193 IS 6 SU S MA 174 BP S59 EP S59 DI 10.1016/j.ajog.2005.10.799 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 993IM UT WOS:000233947800175 ER PT J AU Zhang, C Mammen, MP Klungthong, C Chinnawirotpisan, P Rodpradit, P Kalayanarooj, S Holmes, EC AF Zhang, Chunlin Mammen, Mammen P. Klungthong, Chonticha Chinnawirotpisan, Piyawan Rodpradit, Prinyada Kalayanarooj, Siripen Holmes, Edward C. TI The structure of genetic diversity and the evolutionary processes of dengue viruses circulating in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Zhang, Chunlin; Mammen, Mammen P.; Klungthong, Chonticha; Chinnawirotpisan, Piyawan; Rodpradit, Prinyada] US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Holmes, Edward C.] Penn State Univ, Dept Biol, University Pk, PA 16802 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 14 BP 5 EP 5 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000015 ER PT J AU Bergmann-Leitner, ES Duncan, EH Leitner, WW Williams, JL Lyon, JA AF Bergmann-Leitner, Elke S. Duncan, Elizabeth H. Leitner, Wolfgang W. Williams, Jackie L. Lyon, Jeffrey A. TI Gene gun immunization against circumsporozoite protein of Plasmodium berghei induces protective immunity independent of effector T cells SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Bergmann-Leitner, Elke S.; Duncan, Elizabeth H.; Williams, Jackie L.; Lyon, Jeffrey A.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Leitner, Wolfgang W.] Natl Inst Hlth, Bethesda, MD USA. RI Bergmann-Leitner, Elke/B-3548-2011; Leitner, Wolfgang/F-5741-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Leitner, Wolfgang/0000-0003-3125-5922 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 60 BP 21 EP 21 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000061 ER PT J AU Kiang, RK Adimi, F Zollner, GE Coleman, RE AF Kiang, Richard K. Adimi, Farida Zollner, Gabriela E. Coleman, Russell E. TI Dynamic modeling of malaria transmissions with applications to a study site in western Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Kiang, Richard K.; Adimi, Farida] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Zollner, Gabriela E.; Coleman, Russell E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 64 BP 22 EP 22 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000065 ER PT J AU Prigge, ST Lee, PJ Gaona, H Bhattacharjee, AK Spalding, M Lu, JZ Waters, NC AF Prigge, Sean T. Lee, Patricia J. Gaona, Heather Bhattacharjee, Apurba K. Spalding, Maroya Lu, Jeff Z. Waters, Norman C. TI Targeting the KAS enzymes of Plasmodium falciparum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Prigge, Sean T.; Spalding, Maroya; Lu, Jeff Z.] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA. [Lee, Patricia J.; Gaona, Heather; Bhattacharjee, Apurba K.; Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 93 BP 32 EP 32 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000094 ER PT J AU Weina, PJ Haeberle, A Lowe, MC Cantilena, L Milhous, WK AF Weina, Peter J. Haeberle, Adam Lowe, Michael C. Cantilena, Louis Milhous, Wilbur K. TI Intravenous artesunate: A new product for the treatment of severe and complicated malaria SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Weina, Peter J.; Haeberle, Adam; Lowe, Michael C.; Milhous, Wilbur K.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Cantilena, Louis] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 94 BP 32 EP 32 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000095 ER PT J AU Chavchich, M Gerena, L Peters, J Cheng, Q Kyle, D AF Chavchich, Marina Gerena, Lucia Peters, Jennifer Cheng, Qin Kyle, Dennis TI Mechanisms of Plasmodium falciparum resistance to artemisinin derivatives: Role of Pfmdr1 amplification and expression SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Chavchich, Marina; Peters, Jennifer; Cheng, Qin] Australian Army Malaria Inst, Enoggera, Australia. [Gerena, Lucia; Kyle, Dennis] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 123 BP 41 EP 42 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000124 ER PT J AU Szumias, DE Hanafi, HA Fryauff, DJ Dheranetra, W Gordon, SW Debboun, M AF Szumias, Daniel E. Hanafi, A. Hanafi Fryauff, David J. Dheranetra, Watanaporn Gordon, Scott W. Debboun, Moustafa TI Field evaluation of arthropod repellents against phlebotomine sand flies in Sinai, Egypt SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Szumias, Daniel E.; Hanafi, A. Hanafi; Fryauff, David J.] USN, Med Res Unit 3, Cairo, Egypt. [Dheranetra, Watanaporn; Gordon, Scott W.; Debboun, Moustafa] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Gordon, Scott/B-8875-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 150 BP 50 EP 51 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000151 ER PT J AU Moon, JE Ellis, MC Griffith, ME Hawley, JS Rivard, RG McCall, S Hospenthal, DR Murray, CK AF Moon, James E. Ellis, Michael C. Griffith, Matthew E. Hawley, Joshua S. Rivard, Robert G. McCall, Suzanne Hospenthal, Duane R. Murray, Clinton K. TI Efficacy of telithromycin in the treatment of a hamster model of leptospirosis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Moon, James E.; Ellis, Michael C.; Griffith, Matthew E.; Hawley, Joshua S.; Rivard, Robert G.; McCall, Suzanne; Hospenthal, Duane R.; Murray, Clinton K.] Brooke Army Med Ctr, Houston, TX USA. RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 169 BP 56 EP 57 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000170 ER PT J AU Nevin, RL Niebuhr, DW AF Nevin, Remington L. Niebuhr, David W. TI Incremental cost-benefit of screening for anti-HAV in mass screening and immunization programs: Results of a 2004 US Army seroprevalence survey SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Nevin, Remington L.] Army Med Surveillance Act, Washington, DC USA. [Niebuhr, David W.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 176 BP 59 EP 59 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000177 ER PT J AU Woodrow, J Myles, O Craft, D Ockenhouse, C AF Woodrow, James Myles, Otha Craft, David Ockenhouse, Christian TI Paecilomyces lilacinus infection in a post-lung transplant patient taking campath-1H SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Woodrow, James; Myles, Otha; Craft, David] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Ockenhouse, Christian] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 211 BP 71 EP 71 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000212 ER PT J AU Chretien, JP Blazes, D Bedno, S Coldren, R Culpepper, R Fryauff, D Glass, J Lewis, M Smoak, B Malone, J AF Chretien, Jean-Paul Blazes, David Bedno, Sheryl Coldren, Rodney Culpepper, Randall Fryauff, David Glass, Jonathan Lewis, Michael Smoak, Bonnie Malone, Joseph TI Transnational outbreak response cooperation: Recent experience of the US Department of Defense Global Emerging Infections Surveillance and Response System (DOD-GEIS) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Chretien, Jean-Paul; Malone, Joseph] DoD Global Emerging Infect Surveillance & Respons, Silver Spring, MD USA. [Blazes, David] USN, Med Res Ctr Detachment, Lima, Peru. [Bedno, Sheryl] USA, Med Res Unit Kenya, Nairobi, Kenya. [Coldren, Rodney] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Culpepper, Randall] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Fryauff, David] USN, Med Res Unit 3, Cairo, Egypt. [Glass, Jonathan] USN, Med Res Unit 2, Jakarta, Indonesia. [Lewis, Michael] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Smoak, Bonnie] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 234 BP 79 EP 79 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000235 ER PT J AU Chretien, JP Smoak, B Malone, J AF Chretien, Jean-Paul Smoak, Bonnie Malone, Joseph TI Studies of diagnostic tests for tropical infectious diseases: Assessment of reporting SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Chretien, Jean-Paul; Malone, Joseph] DoD Global Emerging Infect Surveillance & Respons, Silver Spring, MD USA. [Smoak, Bonnie] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 235 BP 79 EP 79 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000236 ER PT J AU Walsh, DS Delacruz, EC Abalos, RM Tan, EV Richards, A Myint, KS AF Walsh, Douglas S. Delacruz, Eduardo C. Abalos, Rodolfo M. Tan, Esterlina V. Richards, Allen Myint, K. S. TI Cynomolgus monkeys infected with Orientia tsutsugamushi (Karp) by intradermal inoculation develop eschar-like lesions and lymphadenopathy akin to human scrub typhus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Walsh, Douglas S.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Delacruz, Eduardo C.; Abalos, Rodolfo M.; Tan, Esterlina V.] Leonard Wood Mem Ctr Leprosy Res, Cebu, Philippines. [Richards, Allen] USN, Med Res Ctr, Silver Spring, MD USA. [Myint, K. S.] US Army Med Component, AFRIMS, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 238 BP 80 EP 80 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000239 ER PT J AU Mayda, E Palmer, DR Hammamieh, R Gunther, V Bisbing, J Sun, W Jett, M Das, R AF Mayda, E. Palmer, D. R. Hammamieh, R. Gunther, V. Bisbing, J. Sun, W. Jett, M. Das, R. TI The four dengue serotypes: Similarities and differences in gene expression pattern SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Mayda, E.; Palmer, D. R.; Hammamieh, R.; Gunther, V.; Bisbing, J.; Sun, W.; Jett, M.; Das, R.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 252 BP 85 EP 85 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000253 ER PT J AU Srikliatkhachorn, A Krautrachue, A Ratanaprakarn, W Wongtapradit, L Nithipanya, N Kalayanarooj, S Nisalak, A Thomas, SJ Gibbons, RV Mammen, MP Libraty, DH Ennis, FA Rothman, AL Green, S AF Srikliatkhachorn, Anon Krautrachue, Anchalee Ratanaprakarn, Warangkana Wongtapradit, Lawan Nithipanya, Narong Kalayanarooj, Siripen Nisalak, Ananda Thomas, Stephen J. Gibbons, Robert V. Mammen, Mammen P. Libraty, Daniel H. Ennis, Francis A. Rothman, Alan L. Green, Sharone TI Detection of plasma leakage in dengue infected patients by serial ultrasonographic studies SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Srikliatkhachorn, Anon; Libraty, Daniel H.; Ennis, Francis A.; Rothman, Alan L.; Green, Sharone] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01605 USA. [Krautrachue, Anchalee; Ratanaprakarn, Warangkana; Wongtapradit, Lawan; Nithipanya, Narong; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Nisalak, Ananda; Thomas, Stephen J.; Gibbons, Robert V.; Mammen, Mammen P.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 255 BP 86 EP 86 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000256 ER PT J AU Li, QG Weina, P Xie, LS Haeberle, A Zhang, J Milhous, W AF Li, Qigui Weina, Peter Xie, Lisa Haeberle, Adam Zhang, Jing Milhous, Wilbur TI The role of quantitative whole body autoradiography and tissue dissection techniques in the evaluation of tissue distribution and metabolic profiles of [14C] artesunate in rats SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Li, Qigui; Weina, Peter; Xie, Lisa; Haeberle, Adam; Zhang, Jing; Milhous, Wilbur] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 339 BP 112 EP 113 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000338 ER PT J AU Si, YZ Zeng, Q Zhang, J Johnson, TO Xie, L Weina, PJ Milhous, WK Lil, QG AF Si, Yuanzheng Zeng, Qiang Zhang, Jing Johnson, Todd O. Xie, Lisa Weina, Peter J. Milhous, Wilbur K. Lil, Qigui TI The toxicity of pyrroloquinazoline and its tetra-acetamide analog associated with their absorption SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Si, Yuanzheng; Zeng, Qiang; Zhang, Jing; Xie, Lisa; Weina, Peter J.; Milhous, Wilbur K.; Lil, Qigui] Walter Reed Army Inst Res, Silver Spring, MD USA. [Johnson, Todd O.] NMRC, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 338 BP 112 EP 112 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000337 ER PT J AU Xie, LSH Li, QG Haeberle, A Zhang, J Weina, P AF Xie, Lisa H. Li, Qigui Haeberle, Adam Zhang, Jing Weina, Peter TI Tissue distribution, pharmacokinetics, mass balance, and elimination of [14C]-artesunate in rats, and protein binding with human and rat blood and plasma SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Xie, Lisa H.; Li, Qigui; Haeberle, Adam; Zhang, Jing; Weina, Peter] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 340 BP 113 EP 113 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000339 ER PT J AU Bhattacharjee, AK Gerena, L Kyle, DE Gutteridge, C AF Bhattacharjee, Apurba K. Gerena, Lucia Kyle, Dennis E. Gutteridge, Clare TI In silico 3D pharmacophore model for chalcone to aid the design and synthesis of novel antimalarial therapeutics SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Bhattacharjee, Apurba K.; Gerena, Lucia; Kyle, Dennis E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Gutteridge, Clare] USN Acad, Annapolis, MD 21402 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 346 BP 114 EP 115 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000345 ER PT J AU Melendez, V Teja-Isavadharm, P Gettayamacin, M Siriyanonda, D Rasameesoraj, M Chanarat, N Lim, A Wannaying, S Chuenarom, W Fukuda, M Weina, P Miller, R AF Melendez, V. Teja-Isavadharm, P. Gettayamacin, M. Siriyanonda, D. Rasameesoraj, M. Chanarat, N. Lim, A. Wannaying, S. Chuenarom, W. Fukuda, M. Weina, P. Miller, R. TI In vivo drug interaction studies of artesunate using rhesus monkeys and LC/MS analysis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Melendez, V.; Teja-Isavadharm, P.; Gettayamacin, M.; Siriyanonda, D.; Rasameesoraj, M.; Chanarat, N.; Lim, A.; Wannaying, S.; Chuenarom, W.; Fukuda, M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Weina, P.; Miller, R.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 345 BP 114 EP 114 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000344 ER PT J AU Siriyanonda, D Teja-Isavadharm, P Chanarat, N Lim, A Wannaying, S Fukuda, M Miller, R Weina, P Melendez, V AF Siriyanonda, D. Teja-Isavadharm, P. Chanarat, N. Lim, A. Wannaying, S. Fukuda, M. Miller, R. Weina, P. Melendez, V. TI LC/MS analysis of artesunate and dihydroartemisinin in plasma following a single step protein precipitation SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Siriyanonda, D.; Teja-Isavadharm, P.; Chanarat, N.; Lim, A.; Wannaying, S.; Fukuda, M.; Melendez, V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Miller, R.; Weina, P.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 344 BP 114 EP 114 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000343 ER PT J AU Bhonsle, J Bhattacharjee, A AF Bhonsle, Jayendra Bhattacharjee, Apurba TI QSAR studies of bacterial enoyl acyl carrier protein reductase (FABI) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Bhonsle, Jayendra; Bhattacharjee, Apurba] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 347 BP 115 EP 115 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000346 ER PT J AU Waters, NC Kathcart, AK Cortes, EA Dennull, RA Bhattacharjee, AK Huddler, DP Prigge, ST Geyer, JA AF Waters, Norman C. Kathcart, April K. Cortes, Edison A. Dennull, Richard A. Bhattacharjee, Apurba K. Huddler, Donald P. Prigge, Sean T. Geyer, Jeanne A. TI Database mining and iterative screening in the search of selective inhibitors of the plasmodial Cyclin Dependent Protein Kinases (CDKS) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Waters, Norman C.; Kathcart, April K.; Cortes, Edison A.; Dennull, Richard A.; Bhattacharjee, Apurba K.; Huddler, Donald P.; Geyer, Jeanne A.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Prigge, Sean T.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 348 BP 115 EP 115 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000347 ER PT J AU Petras, JM Van Gessel, Y Blanchard, TW Miller, RS Bracke, KM Charya, AV AF Petras, J. M. Van Gessel, Y. Blanchard, T. W. Miller, R. S. Bracke, K. M. Charya, A. V. TI Artesunate administered intravenously to rhesus monkeys (Macaca mulatta): A neurology and neuropathology study. III. Brainstem auditory and visual systems nuclear groups SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Petras, J. M.; Bracke, K. M.; Charya, A. V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Van Gessel, Y.; Blanchard, T. W.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Miller, R. S.] Armed Forces Res Inst Med Sci, Silver Spring, Thailand. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 351 BP 116 EP 116 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000350 ER PT J AU Petras, JM Van Gessel, Y Blanchard, TW Gettayacamin, M Miller, RS Bracke, KM Charya, AV AF Petras, J. M. Van Gessel, Y. Blanchard, T. W. Gettayacamin, M. Miller, R. S. Bracke, K. M. Charya, A. V. TI Artesunate administered intravenously to rhesus monkeys (Macaca mulatta): A neurology and neuropathology study. I. The medulla oblongata, pons, and cerebellum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Petras, J. M.; Bracke, K. M.; Charya, A. V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Van Gessel, Y.; Blanchard, T. W.; Gettayacamin, M.; Miller, R. S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 350 BP 116 EP 116 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000349 ER PT J AU Petras, JM Van Gessel, Y Blanchard, TW Miller, S Bracke, KM Charya, AV AF Petras, J. M. Van Gessel, Y. Blanchard, T. W. Miller, S. Bracke, K. M. Charya, A. V. TI Artelinate administered intravenously to rhesus monkeys (Macaca mulatta): A neurology and neuropathology study. I. The medulla oblongata, pons, and cerebellum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Petras, J. M.; Bracke, K. M.; Charya, A. V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Van Gessel, Y.; Blanchard, T. W.; Miller, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 352 BP 117 EP 117 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000351 ER PT J AU Gaona, HW Lee, PJ Prigge, ST Bhattacharjee, AK Gerena, L Roncal, N Lopez-Sanchez, M Heady, TN Waters, NC AF Gaona, Heather W. Lee, Patricia J. Prigge, Sean T. Bhattacharjee, Apurba K. Gerena, Lucia Roncal, Norma Lopez-Sanchez, Miriam Heady, Tiffany N. Waters, Norman C. TI Targeting beta-ketoacyl acp synthase III (KASIII) inhibitors to disrupt fatty acid biosynthesis in Plasmodium falciparum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Gaona, Heather W.; Lee, Patricia J.; Bhattacharjee, Apurba K.; Gerena, Lucia; Roncal, Norma; Lopez-Sanchez, Miriam; Heady, Tiffany N.; Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Prigge, Sean T.] Johns Hopkins Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 358 BP 119 EP 119 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000357 ER PT J AU Bedno, S Coldren, R Achilla, R Liyala, P Eyase, F Wangui, J Akala, H Mbui, J Waters, N AF Bedno, Sheryl Coldren, Rodney Achilla, Rachel Liyala, Pamela Eyase, Fredrick Wangui, Julia Akala, Hosea Mbui, Jane Waters, Norman TI Antimalarial drug resistance in Isiolo, Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Bedno, Sheryl; Achilla, Rachel; Liyala, Pamela; Eyase, Fredrick; Wangui, Julia; Akala, Hosea] USA, Med Res Unit Kenya, Nairobi, Kenya. [Coldren, Rodney] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Mbui, Jane] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Waters, Norman] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 367 BP 122 EP 122 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000366 ER PT J AU Salas, CJ Magill, AJ Ruebush, TK Kain, KC Zhong, KJ Lucas, CM Bautista, CT Bacon, DJ AF Salas, Carola J. Magill, Alan J. Ruebush, Trenton K., II Kain, Kevin C. Zhong, Kathleen J. Lucas, Carmen M. Bautista, Christian T. Bacon, David J. TI Association of single nucleotide polymorphisms in the dihydrofolate reductase and dihydropteroate synthase genes with sulfadoxine-pyrimethamine (SP) resistance in plasmodium falciparum in the Amazon region of Peru SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Salas, Carola J.; Lucas, Carmen M.; Bacon, David J.] USN, Med Res Ctr Detachment, Lima, Peru. [Magill, Alan J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ruebush, Trenton K., II] USAID Bur Global Hlth, Washington, DC USA. [Kain, Kevin C.; Zhong, Kathleen J.] Univ Toronto, Toronto, ON, Canada. [Bautista, Christian T.] US Mil HIV Res Program, Rockville, MD USA. [Bautista, Christian T.] Henry M Jackson Fdn, Rockville, MD USA. RI Bautista, Christian/B-2812-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 368 BP 122 EP 122 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000367 ER PT J AU Coldren, RL Mbui, J Bedno, S Achilla, R Segecha, S Waters, NC AF Coldren, Rodney L. Mbui, Jane Bedno, Sheryl Achilla, Rachel Segecha, Shirley Waters, Norman C. TI Recent antimalarial treatment among Kenyan adults presenting to clinics with positive malaria smears SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Coldren, Rodney L.] Armed Forces Res Inst Med, Bangkok, Thailand. [Mbui, Jane; Achilla, Rachel; Segecha, Shirley] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Bedno, Sheryl] USA, Med Res Unit, Nairobi, Kenya. [Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 378 BP 126 EP 126 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000377 ER PT J AU Coldren, RL WaterS, NC Bedno, S Segecha, S Mbui, J AF Coldren, Rodney L. WaterS, Norman C. Bedno, Sheryl Segecha, Shirley Mbui, Jane TI A case-control study examining recent antimalarial use among patients admitted with malaria and other febrile illnesses in Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Coldren, Rodney L.] USAMC AFRIMS, Bangkok, Thailand. [WaterS, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bedno, Sheryl] USA, Med Res Inst, Nairobi, Kenya. [Segecha, Shirley; Mbui, Jane] Kenya Govt Med Res Ctr, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 381 BP 127 EP 127 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000380 ER PT J AU Grills, AW Ogutu, B K'ungu, A Yadava, A Ghaj, M Stoute, J Withers, M Ockenhouse, C Waitumbi, J AF Grills, Ardath W. Ogutu, Behnhards K'ungu, Amos Yadava, Anjali Ghaj, Mala Stoute, Jose Withers, Mark Ockenhouse, Christian Waitumbi, John TI Longitudinal study of the complexity of Plasmodium falciparum infections in children in Western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Grills, Ardath W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Ogutu, Behnhards; K'ungu, Amos; Waitumbi, John] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Yadava, Anjali; Ghaj, Mala; Stoute, Jose; Withers, Mark; Ockenhouse, Christian] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 385 BP 128 EP 128 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000384 ER PT J AU Davey, RL Hudson, TH O'Neil, MT Gerena, L Kopydlowski, KM Kassim, OO Waters, NC AF Davey, Regina L. Hudson, Thomas H. O'Neil, Michael T. Gerena, Lucia Kopydlowski, Karen M. Kassim, Olakunle O. Waters, Norman C. TI Cloning, expression and in vitro analysis of dihydroorotase from plasmodium falciparum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Davey, Regina L.; Hudson, Thomas H.; O'Neil, Michael T.; Gerena, Lucia; Kopydlowski, Karen M.; Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kassim, Olakunle O.] Howard Univ, Coll Med, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 405 BP 135 EP 135 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000404 ER PT J AU Ponsa, N Zollner, GE Sattabongkot, J Coleman, RE Jones, JW Vaughan, JA AF Ponsa, Narong Zollner, Gabriela E. Sattabongkot, Jetsumon Coleman, Russell E. Jones, James W. Vaughan, Jefferson A. TI Comparative susceptibility of wild-caught (F1) and laboratory colonized mosquitoes to plasmodium vivax in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Ponsa, Narong; Sattabongkot, Jetsumon; Jones, James W.] AFRIMS, Bangkok, Thailand. [Zollner, Gabriela E.; Coleman, Russell E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Vaughan, Jefferson A.] Univ N Dakota, Grand Forks, ND 58201 USA. RI Zollner, Gabriela/B-6073-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 421 BP 140 EP 140 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000420 ER PT J AU Zollner, G Shaman, J Sithiprasasna, R Vaughan, JA Coleman, RE AF Zollner, Gabriela Shaman, Jeffrey Sithiprasasna, Ratana Vaughan, Jefferson A. Coleman, Russell E. TI Using a dynamic hydrology model to quantify seasonal changes in breeding habitat preferences of Anopheles larvae in western Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Zollner, Gabriela; Coleman, Russell E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Shaman, Jeffrey] Harvard Univ, Cambridge, MA 02138 USA. [Sithiprasasna, Ratana] USAMC AFRIMS, Bangkok, Thailand. [Vaughan, Jefferson A.] Univ N Dakota, Grand Forks, ND 58201 USA. RI Zollner, Gabriela/B-6073-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 452 BP 149 EP 149 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000451 ER PT J AU Koenraadt, CJ Tuiten, W Sithiprasasna, R Kijchalao, U Jones, JW Scott, TW AF Koenraadt, Constantianus J. Tuiten, Wieteke Sithiprasasna, Ratana Kijchalao, Udom Jones, James W. Scott, Thomas W. TI Dengue knowledge and practices and their impact on Aedes aegypti populations in Kamphaeng Phet, Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Koenraadt, Constantianus J.; Scott, Thomas W.] Univ Calif Davis, Davis, CA 95616 USA. [Tuiten, Wieteke; Sithiprasasna, Ratana; Kijchalao, Udom; Jones, James W.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 476 BP 156 EP 157 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000475 ER PT J AU Coldren, RL Ofula, V Prosser, TJ Ogolla, F Adungo, F Gaydos, SJ Gehrke, JL Scullin, E Adungo, N AF Coldren, Rodney L. Ofula, Victor Prosser, Trish J. Ogolla, Fredrick Adungo, Ferdinard Gaydos, Steven J. Gehrke, Jennifer L. Scullin, Evan Adungo, Nicholas TI Arboviral IgG antibody prevalence in three Kenyan districts SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Coldren, Rodney L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Ofula, Victor] USA, Med Res Unit, Nairobi, Kenya. [Prosser, Trish J.] Edith Cowan Univ, Perth, WA, Australia. [Ogolla, Fredrick; Adungo, Ferdinard; Adungo, Nicholas] Kenya Govt Med Res Ctr, Busia, Kenya. [Gaydos, Steven J.] Darnell Army Community Hosp, Ft Hood, TX USA. [Gehrke, Jennifer L.] Univ Wisconsin, Sch Med, Madison, WI USA. [Scullin, Evan] Royal Coll Surgeons Ireland, Dublin 2, Ireland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 505 BP 165 EP 166 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000504 ER PT J AU Coward, CA AF Coward, Carl A. TI Evaluation of the diagnostic sensitivity and specificity of the adenoplex assay in the detection of adenovirus type 4 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Coward, Carl A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 513 BP 168 EP 168 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000512 ER PT J AU Laoprasopwattana, K Libraty, DH Endy, TP Nisalak, A Chunsuttiwat, S Vaughn, DW Ennis, FA Rothman, AL Green, S AF Laoprasopwattana, Kamolwish Libraty, Daniel H. Endy, Timothy P. Nisalak, Ananda Chunsuttiwat, Supamit Vaughn, David W. Ennis, Francis A. Rothman, Alan L. Green, Sharone TI The role of pre-existing dengue virus (DV)specific anti body-dependent cellular cytotoxicity in heterologous secondary dengue virus infections SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Laoprasopwattana, Kamolwish] Songklanagarind Hosp, Songkhla, Thailand. [Libraty, Daniel H.; Ennis, Francis A.; Green, Sharone] Univ Massachusetts, Sch Med, Worcester, MA USA. [Endy, Timothy P.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Chunsuttiwat, Supamit] Minist Publ Hlth, Bangkok, Thailand. [Vaughn, David W.] USA, Med Res & Mat Command, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 520 BP 170 EP 170 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000519 ER PT J AU Moore, JM Owino, SO Sichangi, M Lanar, DE Dutta, S Othoro, C Otieno, J Vulule, J Slutsker, L Udhayakumar, V Shi, YP AF Moore, Julie M. Owino, Simon O. Sichangi, Moses Lanar, David E. Dutta, Sheetij Othoro, Caroline Otieno, Juliana Vulule, John Slutsker, Laurence Udhayakumar, Venkatachalam Shi, Ya Ping TI Elispot detection of cytokine responses to malarial antigens in peripheral and placental blood of malaria and malaria/HIV CO-INFECTED Kenyan women SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Moore, Julie M.; Owino, Simon O.; Sichangi, Moses] Univ Georgia, Athens, GA 30602 USA. [Lanar, David E.; Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. [Othoro, Caroline] NYU, New York, NY USA. [Otieno, Juliana] Minist Hlth, Kisumu, Kenya. [Slutsker, Laurence] KEMRI, Ctr Dis Control & Prevent, Kisumu, Kenya. [Udhayakumar, Venkatachalam; Shi, Ya Ping] Ctr Dis Control & Prevent, Chamblee, GA USA. RI Lanar, David/B-3560-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 524 BP 171 EP 172 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000523 ER PT J AU Angov, E Brent-Kirk, A Bowden, SA Soisson, LA Stoute, JA Ockenhouse, CF Cohen, J Diggs, CL Heppner, DG Lyon, JA AF Angov, Evelina Brent-Kirk, Afiya Bowden, Scott A. Soisson, Lorraine A. Stoute, Jose A. Ockenhouse, Christian F. Cohen, Joe Diggs, Carter L. Heppner, Donald G. Lyon, Jeffrey A. TI Analysis of antibody specificities detected by an MSP1-42 fragment specific ELISA following vaccination with FMP1/ASO2A in three diverse populations SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Angov, Evelina; Brent-Kirk, Afiya; Bowden, Scott A.; Ockenhouse, Christian F.; Heppner, Donald G.; Lyon, Jeffrey A.] Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. [Soisson, Lorraine A.; Diggs, Carter L.] US Agcy Int Dev, Washington, DC 20523 USA. [Stoute, Jose A.] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA. [Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 557 BP 183 EP 184 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990000556 ER PT J AU Lehrer, AT Coller, BA Weeks-Levy, CL McClelland, A Clements, DE Aniya, CS Lieberman, MM Wong, TA Kriederman, BM Ogata, SA Waller, DF Basilio, B Rohlinger, EM Pratt, WS Bakken, R Hart, MK AF Lehrer, Axel T. Coller, Beth-Ann Weeks-Levy, Carolyn L. McClelland, Alan Clements, David E. Aniya, Charmaine S. Lieberman, Michael M. Wong, Teri-Ann Kriederman, Benjamin M. Ogata, Steven. A. Waller, David F. Basilio, Beverly Rohlinger, Eric M. Pratt, William S. Bakken, Russ Hart, Mary Kate TI Toward a recombinant vaccine against Filovirus infection - Expression and immunogenicity of soluble viral antigens SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Lehrer, Axel T.; Coller, Beth-Ann; Weeks-Levy, Carolyn L.; McClelland, Alan; Clements, David E.; Aniya, Charmaine S.; Lieberman, Michael M.; Wong, Teri-Ann; Kriederman, Benjamin M.; Ogata, Steven. A.; Waller, David F.; Basilio, Beverly; Rohlinger, Eric M.] Hawaii Biotech Inc, Aiea, HI USA. [Pratt, William S.; Bakken, Russ; Hart, Mary Kate] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 583 BP 192 EP 193 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001006 ER PT J AU Chretien, JP Prudhomme, W Awuondo, K Tang, D Remich, S Ogutu, B Nanakorn, A Ohrt, C AF Chretien, Jean-Paul Prudhomme, Wendy Awuondo, Ken Tang, Doug Remich, Shon Ogutu, Bernard Nanakorn, Ampon Ohrt, Colin TI Quality assurance for malaria clinical trial microscopy based on theoretical and empirical evidence SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Chretien, Jean-Paul] DoD Global Emerging Infect Surveillance & Respose, Silver Spring, MD USA. [Prudhomme, Wendy] Natl Inst Hlth, Bethesda, MD USA. [Awuondo, Ken; Remich, Shon; Ogutu, Bernard; Nanakorn, Ampon] USA, Med Res Unit Kenya, Kisumu, Kenya. [Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 604 BP 200 EP 200 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001027 ER PT J AU Fukuda, MM Krudsood, S Miller, RS Jongsakul, K Noedl, H Ittiverakul, M Buathong, N Warrasak, S Euswas, A Chalermrut, G Tangpukdee, N Deen, KC Neate, C Ohrt, CK Looareesuwan, S AF Fukuda, Mark M. Krudsood, Srivicha Miller, Robert S. Jongsakul, Krisada Noedl, Harald Ittiverakul, Mali Buathong, Nillawan Warrasak, Sukhuma Euswas, Ataya Chalermrut, Gobsiri Tangpukdee, Noppadon Deen, Keith C. Neate, Colin Ohrt, Colin K. Looareesuwan, Sornchai TI A randomized, double blinded study of the efficacy and safety of tafenoguine monotherapy for the treatment of Plasmodium vivax in adults SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Fukuda, Mark M.; Miller, Robert S.; Jongsakul, Krisada; Noedl, Harald; Ittiverakul, Mali; Buathong, Nillawan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Krudsood, Srivicha; Chalermrut, Gobsiri; Tangpukdee, Noppadon; Looareesuwan, Sornchai] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Warrasak, Sukhuma; Euswas, Ataya] Mahidol Univ, Ramathibodi Fac Hosp, Bangkok 10700, Thailand. [Deen, Keith C.; Neate, Colin] GlaxoSmithKline Inc, Collegeville, PA USA. [Ohrt, Colin K.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 632 BP 208 EP 209 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001055 ER PT J AU Gilmore, L Hochberg, L Rowton, E Lawyer, P Coleman, R AF Gilmore, Lara Hochberg, Lisa Rowton, Edgar Lawyer, Phillip Coleman, Russell TI A study of storage conditions for sand fly samples to be tested by real time PCR SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Gilmore, Lara; Hochberg, Lisa; Rowton, Edgar; Lawyer, Phillip; Coleman, Russell] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 637 BP 210 EP 211 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001060 ER PT J AU Hawley, JS Reitstetter, RE Reeb, BA Stuart, SK Beckius, ML Murray, CK Hospenthal, DR AF Hawley, Joshua S. Reitstetter, Raven E. Reeb, Barbara A. Stuart, Saundra K. Beckius, Mirium L. Murray, Clinton K. Hospenthal, Duane R. TI Detection and identification of pathogenic and saprophytic leptospira strains by a PCR matrix approach using multiple primers SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Hawley, Joshua S.; Reitstetter, Raven E.; Reeb, Barbara A.; Stuart, Saundra K.; Beckius, Mirium L.; Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 653 BP 216 EP 216 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001076 ER PT J AU Caci, JB Brown, DA Weina, PJ AF Caci, Jennifer B. Brown, Deanna A. Weina, Peter J. TI A recent history of leishmania, malaria, and other endemic diseases in Iraq SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Caci, Jennifer B.] Ctr Hlth Promot & Prevent Med, Atlanta, GA USA. [Brown, Deanna A.] US Army Special Operat Command, Ft Bragg, NC USA. [Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 678 BP 224 EP 224 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001101 ER PT J AU Liebig, C Shoemaker, D Hochberg, L Gilmore, L Van de Wyngaerde, M Weina, P Coleman, R Wortmann, G Magill, A AF Liebig, Caroline Shoemaker, David Hochberg, Lisa Gilmore, Lara Van de Wyngaerde, Marshall Weina, Peter Coleman, Russell Wortmann, Glenn Magill, Alan TI An overview of the steps required to gain cap accreditation for a clinical laboratory running a molecular assay for the diagnosis of cutaneous leishmaniasis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Liebig, Caroline; Hochberg, Lisa; Gilmore, Lara; Van de Wyngaerde, Marshall; Weina, Peter; Coleman, Russell; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. [Shoemaker, David] USA, Med Mat Dev Activ, Ft Detrick, MD USA. [Wortmann, Glenn] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 696 BP 230 EP 230 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001119 ER PT J AU Van de Wyngaerde, M Shoemaker, D Hochberg, L Gilmore, W Gilmore, L Liebig, C Weinal, P Coleman, R Wortmann, G AF Van de Wyngaerde, Marshall Shoemaker, David Hochberg, Lisa Gilmore, Wayne Gilmore, Lara Liebig, Caroline Weinal, Peter Coleman, Russell Wortmann, Glenn TI Development and validation of an FDA-cleared real-time PCR diagnostic kit for Old World Cutaneous Leishmaniasis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Van de Wyngaerde, Marshall; Hochberg, Lisa; Gilmore, Wayne; Gilmore, Lara; Liebig, Caroline; Weinal, Peter; Coleman, Russell] Walter Reed Army Inst Res, Silver Spring, MD USA. [Shoemaker, David] USA, Med Mat Dev Activ, Ft Detrick, MD USA. [Wortmann, Glenn] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 698 BP 230 EP 230 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001121 ER PT J AU Monteville, MR Riddle, MS Rockabrand, DM Putna, S Baht, U Brooks, K Bland, J Frenck, RW Sanders, JW AF Monteville, Marshall R. Riddle, Mark S. Rockabrand, David M. Putna, Shannon Baht, Usha Brooks, Kenneth Bland, Jamie Frenck, Robert W. Sanders, John W. TI Epidemiology of diarrhea among deployed military personnel in support of operation Iraqi freedom and operation enduring freedom SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Monteville, Marshall R.; Riddle, Mark S.; Rockabrand, David M.; Sanders, John W.] USN, Med Res Unit 3, Cairo, Egypt. [Putna, Shannon] USN, Med Res Unit 2, Jakarta, Indonesia. [Baht, Usha; Brooks, Kenneth; Bland, Jamie] ARCENT Troop Med Clin, Doha, Qatar. [Frenck, Robert W.] Univ Calif Los Angeles, Los Angeles, CA USA. RI Riddle, Mark/A-8029-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 701 BP 231 EP 231 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001124 ER PT J AU Ohrt, C AF Ohrt, Colin TI G6PD-deficiency: Implications in public health and drug development SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 710 BP 234 EP 234 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001133 ER PT J AU Schaecher, KE Ellis, R Siludjai, D Laoboonchai, A Fukuda, M AF Schaecher, Kurt E. Ellis, Ruth Siludjai, Duangkamon Laoboonchai, Anintita Fukuda, Mark TI Evaluation of leptospirosis by polymerase chain reaction (PCR) in cultured samples and culture positive packed red blood cells SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Schaecher, Kurt E.; Ellis, Ruth; Siludjai, Duangkamon; Laoboonchai, Anintita; Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 715 BP 236 EP 236 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001138 ER PT J AU Nisalak, A Jarman, RG Kalayanarooj, S Narupiti, S Thirawuth, V Nutkamhang, N Tararut, P Srisongkram, P Mammen, MP AF Nisalak, Ananda Jarman, Richard G. Kalayanarooj, Siripen Narupiti, Sumitda Thirawuth, Vipa Nutkamhang, Naowaybol Tararut, Pairote Srisongkram, Panor Mammen, Mammen P. TI Sensitivity of dengue virus isolation by C6/36 cell culture and mosquito inoculation of nested RT-PCR positive clinical samples SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Kalayanarooj, Siripen] Queen Sirkit Natl Inst Child Hlth, Bangkok, Thailand. [Nisalak, Ananda; Jarman, Richard G.; Narupiti, Sumitda; Thirawuth, Vipa; Nutkamhang, Naowaybol; Tararut, Pairote; Srisongkram, Panor; Mammen, Mammen P.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 720 BP 238 EP 238 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001143 ER PT J AU Bashyam, HS Toyosaki-Maeda, T Stephens, HA Mammen, MP Endy, TP Vaughn, DW Kalayanarooj, S Libraty, DH Green, S Ennis, FA Rothman, AL AF Bashyam, Hema S. Toyosaki-Maeda, Tomoko Stephens, Henry A. Mammen, Mammen P. Endy, Timothy P. Vaughn, David W. Kalayanarooj, Siripen Libraty, Daniel H. Green, Sharone Ennis, Francis A. Rothman, Alan L. TI Frequency and phenotypic analysis of dengue epitope-specific T cells in infected Thai subjects during acute illness and convalescence SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Bashyam, Hema S.; Toyosaki-Maeda, Tomoko; Libraty, Daniel H.; Green, Sharone; Ennis, Francis A.; Rothman, Alan L.] Univ Massachusetts, Med Ctr, Worcester, MA 01605 USA. [Stephens, Henry A.] UCL, Ctr Nephrol, London, England. [Mammen, Mammen P.] USA Med Component Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. [Endy, Timothy P.; Vaughn, David W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kalayanarooj, Siripen] Queen Sirkit Natl Inst Child Hlth, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 726 BP 240 EP 240 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001149 ER PT J AU Jackson, JE Iwu, MM Okunji, CO Kollmar, E Rowton, ED AF Jackson, Joan E. Iwu, Maurice M. Okunji, Christopher O. Kollmar, Eleanor Rowton, Edgar D. TI Chronic rodent leishmaniasis (VL, CL, MCL, DCL): Cell receptors and pathology SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Jackson, Joan E.; Rowton, Edgar D.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Iwu, Maurice M.; Okunji, Christopher O.] Bioresources Dev & Conservat Programme, Silver Spring, MD USA. [Kollmar, Eleanor] Village Anim Hosp, Millbrook, NY USA. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 781 BP 257 EP 257 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001204 ER PT J AU Guyah, B Thathy, V Orago, A Otieno, W Stoute, JA AF Guyah, Bernard Thathy, Vandana Orago, Alloyce Otieno, Walter Stoute, Jose A. TI Studies of the age-dependent prevalence of the Swain-Langley and McCoy blood group polymorphisms of complement receptor 1 in western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Guyah, Bernard; Orago, Alloyce] Kenyatta Univ, Nairobi, Kenya. [Thathy, Vandana; Otieno, Walter] USA, Med Res Unit, Nairobi, Kenya. [Thathy, Vandana; Otieno, Walter] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Stoute, Jose A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 791 BP 260 EP 261 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001214 ER PT J AU Mibel, E Orago, A Stoute, JA AF Mibel, Erick Orago, Alloyce Stoute, Jose A. TI Class and subclass antibody analysis of circulating immune complexes in children with severe Plasmodium falciparum malaria SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Mibel, Erick; Orago, Alloyce] Kenyatta Univ, Nairobi, Kenya. [Stoute, Jose A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 794 BP 261 EP 262 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001217 ER PT J AU Otieno, WO Estambale, B Odera, M Aluoch, J Stoute, JA AF Otieno, Walter O. Estambale, Benson Odera, Michael Aluoch, Joash Stoute, Jose A. TI Expression of erythrocyte complement regulatory proteins in individuals with sickle cell trait and normal hemoglobin in a malaria endemic area of western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Otieno, Walter O.; Odera, Michael] USA, Med Res Unit Kenya, Kenya Med Res Inst, Nairobi, Kenya. [Otieno, Walter O.; Estambale, Benson; Aluoch, Joash] Univ Nairobi, Coll Hlth Sci, Nairobi, Kenya. [Odera, Michael] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Stoute, Jose A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 793 BP 261 EP 261 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001216 ER PT J AU Cannard, KR Bauman, R Cabezas, M Caridha, D Du, F Gomez-Lobo, R Park, M Dow, G AF Cannard, Kevin R. Bauman, Richard Cabezas, Miriam Caridha, Diana Du, Fu Gomez-Lobo, Rosario Park, Michael Dow, Geoffrey TI Mefloquine induces proprioceptive motor system damage in rats SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Cannard, Kevin R.; Bauman, Richard; Cabezas, Miriam; Caridha, Diana; Du, Fu; Gomez-Lobo, Rosario; Park, Michael; Dow, Geoffrey] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 803 BP 264 EP 264 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001226 ER PT J AU Dow, GS Bauman, R Cabezas, M Caridha, D Du, F Gomez-Lobo, R Park, M Smith, K Cannard, K AF Dow, Geoffrey S. Bauman, Richard Cabezas, Miriam Caridha, Diana Du, Fu Gomez-Lobo, Rosario Park, Michael Smith, Kirsten Cannard, Kevin TI Mefloquine induces dose-related neurological effects in rats SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Dow, Geoffrey S.; Bauman, Richard; Cabezas, Miriam; Caridha, Diana; Gomez-Lobo, Rosario; Park, Michael; Smith, Kirsten; Cannard, Kevin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Du, Fu] FD Neurotechnol, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 804 BP 265 EP 265 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001227 ER PT J AU Lowe, CD Gerena, L Kyle, DE AF Lowe, Christopher D. Gerena, Lucia Kyle, Dennis E. TI Evaluation of dihydroartemisinin-piperaquine drug combinations in vitro SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Lowe, Christopher D.; Gerena, Lucia; Kyle, Dennis E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 805 BP 265 EP 265 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001228 ER PT J AU Dennull, RA Cortes, EA Kathcart, AK Gerena, L Huddler, DP Bhattacharjee, AK Geyer, JA Prigge, ST Waters, NC AF Dennull, Richard A. Cortes, Edison A. Kathcart, April K. Gerena, Lucia Huddler, Donald P. Bhattacharjee, Apurba K. Geyer, Jeanne A. Prigge, Sean T. Waters, Norman C. TI Identification of thiophene sulfonamides as specific inhibitors of plasmodial cyclin dependent protein kinases SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Dennull, Richard A.; Cortes, Edison A.; Kathcart, April K.; Gerena, Lucia; Huddler, Donald P.; Bhattacharjee, Apurba K.; Geyer, Jeanne A.; Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Prigge, Sean T.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 808 BP 266 EP 266 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001231 ER PT J AU Gutteridge, CE Curtis, SM Nichols, DA Shearer, T AF Gutteridge, Clare E. Curtis, Sean M. Nichols, Daniel A. Shearer, Todd TI Antimalarial activity of 2,4-dimethoxy-4 '-butoxychalcone and its metabolites SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Gutteridge, Clare E.; Curtis, Sean M.] USN Acad, Annapolis, MD 21402 USA. [Nichols, Daniel A.; Shearer, Todd] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 813 BP 267 EP 267 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001236 ER PT J AU Schlehser, GA Shieh, HM Nevchas, IK Terpinski, J Ager, AL Skillman, DR Milhous, WK Kyle, DE Edstein, MD Riechmann, KH Sibley, CH Canfield, CJ Jacobus, LR Jacobus, DP AF Schlehser, Guy A. Shieh, Hong-Ming Nevchas, Isabelle K. Terpinski, Jacek Ager, Arba L. Skillman, Donald R. Milhous, Wil K. Kyle, Dennis E. Edstein, Michael D. Riechmann, Karl H. Sibley, Carol H. Canfield, Craig J. Jacobus, Laura R. Jacobus, David P. TI Pre-clinical development of JPC-2056-1, a third generation antifolate SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Schlehser, Guy A.; Shieh, Hong-Ming; Nevchas, Isabelle K.; Terpinski, Jacek; Jacobus, Laura R.; Jacobus, David P.] Jacobus Pharmaceut Co Inc, Princeton, NJ USA. [Ager, Arba L.] Univ Miami, Sch Med, Miami, FL USA. [Skillman, Donald R.; Milhous, Wil K.; Kyle, Dennis E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sibley, Carol H.] Univ Washington, Seattle, WA 98195 USA. [Canfield, Craig J.] Pharmaceut Syst Inc, Talent, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 812 BP 267 EP 267 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001235 ER PT J AU Gerena, L Dow, GS Ellis, WY Caridha, D Heady, TN Coyne, PE Magill, AJ Kyle, DE Milhous, WK AF Gerena, Lucia Dow, Geoffrey S. Ellis, William Y. Caridha, Diana Heady, Tiffany N. Coyne, Phillip E. Magill, Alan J. Kyle, Dennis E. Milhous, Wilbur K. TI Development of stereoselective lariam analogs would have no advantage over lariam against emerging resistance in West Africa SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Gerena, Lucia; Dow, Geoffrey S.; Ellis, William Y.; Caridha, Diana; Heady, Tiffany N.; Magill, Alan J.; Kyle, Dennis E.; Milhous, Wilbur K.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Coyne, Phillip E.] NIAID, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 818 BP 269 EP 269 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001241 ER PT J AU Kyle, DE Gerena, L Pitzer, K Gettyacamin, M AF Kyle, Dennis E. Gerena, Lucia Pitzer, Kevin Gettyacamin, Montip TI Antimalarial activity of 4(1H)-quinolones SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Kyle, Dennis E.; Gerena, Lucia; Pitzer, Kevin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Gettyacamin, Montip] AFRIMS, Bangkok, Thailand. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 822 BP 270 EP 270 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001245 ER PT J AU Remich, SA Ntomburi, S Otieno, E Ogutu, B Polhemus, M Ohrt, C AF Remich, Shon A. Ntomburi, Stephen Otieno, Emily Ogutu, Berhnards Polhemus, Mark Ohrt, Colin TI Malaria attack rate determination and antimalarial prophylaxis phase II-III clinical trial feasibility at an institute of higher education in Western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Remich, Shon A.; Ntomburi, Stephen; Otieno, Emily; Ogutu, Berhnards; Polhemus, Mark; Ohrt, Colin] USA, Med Res Unit, APO, AE USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 825 BP 271 EP 271 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001248 ER PT J AU Spalding, M Lu, JZ Lee, P Waters, N Prigge, S AF Spalding, Maroya Lu, Jeff Z. Lee, Patricia Waters, Norman Prigge, Sean TI Inhibition of fatty acid biosynthesis in Plasmodium falciparum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Spalding, Maroya; Lu, Jeff Z.; Prigge, Sean] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA. [Lee, Patricia; Waters, Norman] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 824 BP 271 EP 271 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001247 ER PT J AU Teja-Isavadharm, P Siriyanonda, D Rasameesoraj, M Gettayacamin, M Van Gessel, Y Chanarat, N Lim, A Wannaying, S Chuenarom, W Melendez, V Fukuda, M Lin, AJ Kyle, DE AF Teja-Isavadharm, Paktiya Siriyanonda, Duangsuda Rasameesoraj, Maneerat Gettayacamin, Montip Van Gessel, Yvone Chanarat, Nitima Lim, Apassorn Wannaying, Srisombat Chuenarom, Weerawan Melendez, Victor Fukuda, Mark Lin, Ai J. Kyle, Dennis E. TI A pharmacokinetic/pharmacodynamic screening model for lead antimalarials and their active metabolites in rhesus monkeys SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Teja-Isavadharm, Paktiya; Siriyanonda, Duangsuda; Rasameesoraj, Maneerat; Gettayacamin, Montip; Van Gessel, Yvone; Chanarat, Nitima; Lim, Apassorn; Wannaying, Srisombat; Chuenarom, Weerawan; Melendez, Victor; Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Lin, Ai J.; Kyle, Dennis E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 827 BP 271 EP 272 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001250 ER PT J AU Smilkstein, MJ Kelly, JX Winter, R Kyle, DE Riscoe, M AF Smilkstein, Martin J. Kelly, Jane X. Winter, Rolf Kyle, Dennis E. Riscoe, Michael TI Orphenadrine as a chemosensitizer against quinoline-resistant malaria SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Smilkstein, Martin J.; Kelly, Jane X.; Winter, Rolf; Riscoe, Michael] Portland VA Med Ctr, Portland, OR USA. [Kyle, Dennis E.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 832 BP 274 EP 274 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001255 ER PT J AU Ogutu, BR Withers, MR Onyango, M Otieno, A Waitumbi, JN Heppner, DG Tucker, MSK Milman, J Leach, A Spiessens, B Ballou, R Diggs, C Stoute, J AF Ogutu, Bernhards R. Withers, Mark R. Onyango, Melanie Otieno, Allan Waitumbi, John N. Heppner, Donald G. Tucker, Kathryn M. S. Milman, Jessica Leach, Amanda Spiessens, Bert Ballou, Ripley Diggs, Carter Stoute, Jose TI A longitudinal cohort study of the epidemiology of pediatric malaria in Kombewa division, western Kenya: Update SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Ogutu, Bernhards R.; Onyango, Melanie; Otieno, Allan; Waitumbi, John N.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Withers, Mark R.] USAMRU K, Kenya Med Res Inst, Kisumu, Kenya. [Heppner, Donald G.] Walter Reed Army Inst Res, Maryland, MD USA. [Tucker, Kathryn M. S.] Stat Collaborat Inc, Washington, DC USA. [Milman, Jessica] PATH Malaria Vaccine Initiat, Washington, DC USA. [Milman, Jessica] GlaxoSmithKline Biol, Rixensart, Belgium. [Diggs, Carter] US Agcy Int Dev, Malaria Vaccine Dev Project, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 850 BP 280 EP 280 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001273 ER PT J AU Weiss, WR Jiang, G Conteh, S Williams, J Richie, T AF Weiss, Walter R. Jiang, George Conteh, Solomon Williams, Jack Richie, Thomas TI The role of effector CD8+T cells in monkeys immunized with irradiated malaria sporozoites SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Weiss, Walter R.; Jiang, George; Conteh, Solomon; Richie, Thomas] USN, Med Res Ctr, Silver Spring, MD USA. [Williams, Jack] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 861 BP 284 EP 284 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001284 ER PT J AU McGrath, SM Bayat, B Donner, MN Mettens, P Collignon, C Pau, MG Dubois, P Goudsmit, J Cohen, J Heppner, DG Stewart, VA AF McGrath, Shannon M. Bayat, Babak Donner, Marie-Noalle Mettens, Pascal Collignon, Catherine Pau, Maria Grazia Dubois, Patrice Goudsmit, Jaap Cohen, Joe Heppner, D. Gray Stewart, V. Ann TI Use of 6-color flow cytometry to measure immune response in rhesus macaques immunized with malaria vaccine candidates SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [McGrath, Shannon M.; Heppner, D. Gray; Stewart, V. Ann] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bayat, Babak; Donner, Marie-Noalle; Mettens, Pascal; Collignon, Catherine; Dubois, Patrice; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Pau, Maria Grazia; Goudsmit, Jaap] Crucell Holland BV, Leiden, Netherlands. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 880 BP 290 EP 290 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001303 ER PT J AU Shott, J Pau, MG Demoitia, MA Custers, JH McGrath, S Dubois, P Ophorst, O Dubois, MC Komisar, J Cohen, J Goudsmit, J Heppner, DG Stewart, VA AF Shott, Joseph Pau, Maria Grazia Demoitia, Marie-Ange Custers, Jerome H. McGrath, Shannon Dubois, Patrice Ophorst, Olga Dubois, Marie-Claude Komisar, Jack Cohen, Joe Goudsmit, Jaap Heppner, D. Gray Stewart, V. Ann TI Evaluation of immunogenicity of adenovirus-PFCS malaria vaccine candidates in mice SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Shott, Joseph; McGrath, Shannon; Komisar, Jack; Heppner, D. Gray; Stewart, V. Ann] Walter Reed Army Inst Res, Silver Spring, MD USA. [Pau, Maria Grazia; Custers, Jerome H.; Ophorst, Olga; Goudsmit, Jaap] Crucell Holland BV, Leiden, Netherlands. [Demoitia, Marie-Ange; Dubois, Patrice; Dubois, Marie-Claude; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 881 BP 290 EP 290 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001304 ER PT J AU Cobb, M McGrath, S Dutta, S Ware, LA Lalitha, PV Cohen, J Lanar, DE Heppner, DG Stewart, VA AF Cobb, Michelle McGrath, Shannon Dutta, Sheetij Ware, Lisa A. Lalitha, P. V. Cohen, Joe Lanar, David E. Heppner, D. Gray Stewart, V. Ann TI Interferon-gamma elispot responses to pfama-1/E, a recombinant protein blood-stage Plasmodium falciparum vaccine candidate, in rhesus macaques SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Cobb, Michelle; McGrath, Shannon; Dutta, Sheetij; Ware, Lisa A.; Lalitha, P. V.; Lanar, David E.; Heppner, D. Gray; Stewart, V. Ann] Walter Reed Army Inst Res, Silver Spring, MD USA. [Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. RI Lanar, David/B-3560-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 883 BP 291 EP 291 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001306 ER PT J AU Angov, E Khan, F N-Leitner, ESB Kincaid, R Heppner, DG Soisson, L Cohen, J Diggs, CL Lyon, JA AF Angov, Evelina Khan, Farhat N-Leitner, Elke S. Bergman Kincaid, Randall Heppner, Donald G. Soisson, Lorraine Cohen, Joe Diggs, Carter L. Lyon, Jeffrey A. TI Antibodies raised against Plasmodium falciparum MSP1-42 expressed from a fully codon-harmonized gene are significantly more growth inhibitory than those raised against the same antigen expressed from a partially codon-harmonized gene SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Angov, Evelina; Khan, Farhat; N-Leitner, Elke S. Bergman; Heppner, Donald G.; Lyon, Jeffrey A.] Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. [Kincaid, Randall] Veritas Inc, Rockville, MD USA. [Soisson, Lorraine; Diggs, Carter L.] US Agcy Int Dev, Washington, DC 20523 USA. [Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 887 BP 292 EP 292 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001310 ER PT J AU Li, C Wilkerson, R AF Li, Cong Wilkerson, Richard TI Intragenomic ITS2 variation and its impact on PCR identification of an anopheles malaria vector group SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Li, Cong; Wilkerson, Richard] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 906 BP 297 EP 297 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001329 ER PT J AU Houng, HSH Smith, D Zhao, BT Chan, A Luciano, S Dowler, M McLean-Cooper, N Coleman, R Sun, W Putnak, R AF Houng, Huo-Shu H. Smith, Derek Zhao, Bangti Chan, Adeline Luciano, Sarah Dowler, Megan McLean-Cooper, Nancy Coleman, Russell Sun, Wellington Putnak, Robert TI Time-course study of dengue 2 viral replication and RNA sequence variation within Aedes aegypti SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Houng, Huo-Shu H.; Smith, Derek; Zhao, Bangti; Chan, Adeline; Luciano, Sarah; Dowler, Megan; McLean-Cooper, Nancy; Coleman, Russell; Sun, Wellington; Putnak, Robert] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 920 BP 302 EP 302 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001343 ER PT J AU Stancil, J Morrison, A Chan, A Sihuinchia, M Astete, H Fernandez, R Lopez, V AF Stancil, Jeff Morrison, Amy Chan, Adeline Sihuinchia, Moises Astete, Helvio Fernandez, Roberto Lopez, Victor TI Preliminary evaluations of dengue vector control methodologies in Iquitos, Peru SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Stancil, Jeff; Fernandez, Roberto; Lopez, Victor] USN, Med Res Ctr, APO, AE USA. [Morrison, Amy; Astete, Helvio] Univ Calif Davis, Davis, CA 95616 USA. [Chan, Adeline] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sihuinchia, Moises] Lab Referencial, Direcc Salud, Iquitos, Peru. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 930 BP 305 EP 305 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001353 ER PT J AU Dupuy, L Richards, M Paidhungat, M Lohre, JA Kuznetsova, MA Silvera, P Draghia, R Whalen, RG Schmaljohn, C Locher, CP AF Dupuy, Lesley Richards, Michelle Paidhungat, Madan Lohre, Jack A. Kuznetsova, Maria A. Silvera, Peter Draghia, Ruxandra Whalen, Robert G. Schmaljohn, Connie Locher, Christopher P. TI Improvement of Venezuelan equine encephalitis virus vaccine envelope antigens by using directed molecular evolution SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Dupuy, Lesley; Richards, Michelle; Schmaljohn, Connie] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Paidhungat, Madan; Lohre, Jack A.; Kuznetsova, Maria A.; Whalen, Robert G.; Locher, Christopher P.] Maxygen Inc, Redwood City, CA USA. [Silvera, Peter] So Res Inst, Frederick, MD USA. [Draghia, Ruxandra] Advisys, The Woodlands, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 969 BP 318 EP 318 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001392 ER PT J AU Foley, DH Wilkerson, RC AF Foley, Desmond H. Wilkerson, Richard C. TI The species-rich Anopheles annulipes complex SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Foley, Desmond H.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Suitland, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 995 BP 327 EP 327 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001418 ER PT J AU Rueda, LM Foley, DH Peterson, AT Wilkerson, RC AF Rueda, Leopoldo M. Foley, Desmond H. Peterson, A. Townsend Wilkerson, Richard C. TI Geographic and ecologic distribution of the malaria vector, Anopheles sinensis in Korea and other parts of Asia SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Rueda, Leopoldo M.; Foley, Desmond H.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Peterson, A. Townsend] Univ Kansas, Museum Nat Hist, Lawrence, KS 66045 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 996 BP 327 EP 327 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001419 ER PT J AU Chai, SK Fried, M Mutabingwa, T Duffy, P AF Chai, Sanders K. Fried, Michal Mutabingwa, Theonest Duffy, Patrick TI Regulatory T cell function in tanzanian infants varies according to maternal gravidity and placental malaria status at delivery SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Chai, Sanders K.; Fried, Michal] Seattle Biomed Res Inst, Mother Offspring Malaria Study, Seattle, WA 98109 USA. [Mutabingwa, Theonest] London Sch Hyg & Trop Med, London WC1, England. [Mutabingwa, Theonest; Duffy, Patrick] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 1012 BP 332 EP 332 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001435 ER PT J AU Tsuboi, T Takeo, S Iriko, H Jin, L Han, ET Kaneko, O Sattabongkot, J Udomsangpetch, R Sawasaki, T Torii, M Endo, Y AF Tsuboi, Takafumi Takeo, Satoru Iriko, Hideyuki Jin, Ling Han, Eun-Taek Kaneko, Osamu Sattabongkot, Jetsumon Udomsangpetch, Rachanee Sawasaki, Tatsuya Torii, Motomi Endo, Yaeta TI Wheat germ cell-free system: A powerful tool to identify novel vaccine candidates based on the Plasmodium Falciparum genome database SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Tsuboi, Takafumi; Takeo, Satoru; Iriko, Hideyuki; Jin, Ling; Han, Eun-Taek; Sawasaki, Tatsuya; Endo, Yaeta] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime, Japan. [Kaneko, Osamu; Torii, Motomi] Ehime Univ, Sch Med, Toon, Ehime, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Udomsangpetch, Rachanee] Mahidol Univ, Fac Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 1029 BP 338 EP 338 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001452 ER PT J AU Wu, Y Miles, AP Lambert, L Muratova, O Orcutt, A Keister, D Bello, S Sattabongkot, J Miller, L Long, C Saul, A AF Wu, Yimin Miles, Aaron P. Lambert, Lynn Muratova, Olga Orcutt, Andrew Keister, David Bello, Sheila Sattabongkot, Jetsumon Miller, Louis Long, Carole Saul, Allan TI Aiming for sustained high-level antibody responses: formulation of PFS25 and PVS25 transmission blocking vaccines SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Wu, Yimin; Miles, Aaron P.; Lambert, Lynn; Muratova, Olga; Orcutt, Andrew; Keister, David; Bello, Sheila; Miller, Louis; Long, Carole; Saul, Allan] NIAID, Malaria Vaccine Dev Branch, Rockville, MD USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. OI Saul, Allan/0000-0003-0665-4091 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 1035 BP 340 EP 340 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001458 ER PT J AU Thathy, V Moulds, JM Guyah, B Otieno, W Stoute, JA AF Thathy, Vandana Moulds, Joann M. Guyah, Bernard Otieno, Walter Stoute, Jose A. TI Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Thathy, Vandana; Guyah, Bernard; Otieno, Walter] USA, Med Res Unit Kenya, Nairobi, Kenya. [Moulds, Joann M.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Stoute, Jose A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 1065 BP 350 EP 350 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001488 ER PT J AU Thomas, SJ Pardo, J Martin, NC Endy, T Green, S Porter, KR Burgess, TH AF Thomas, Stephen J. Pardo, Jorge Martin, Nicole C. Endy, Timothy Green, Sharone Porter, Kevin R. Burgess, Timothy H. TI DC-SIGN neutralization assay demonstrates high serotype specificity with paired sera from primary dengue infections SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Thomas, Stephen J.; Endy, Timothy] Walter Reed Army Inst Res, Silver Spring, MD USA. [Pardo, Jorge; Martin, Nicole C.; Porter, Kevin R.; Burgess, Timothy H.] USN, Med Res Ctr, Silver Spring, MD USA. [Green, Sharone] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 1071 BP 353 EP 353 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001494 ER PT J AU Walsh, DS Gettayacamin, M Lyon, JA Leitner, WW Stewart, A Pichyangkul, S Gosi, P Tongtawe, P Holland, CA Kolodny, N Cohen, J Voss, G Ballou, R Heppner, DG Heppner, DG AF Walsh, Douglas S. Gettayacamin, Montip Lyon, Jeffrey A. Leitner, Wolfgang W. Stewart, Ann Pichyangkul, Sathit Gosi, Panita Tongtawe, Pongsri Holland, Carolyn A. Kolodny, Nelly Cohen, Joe Voss, Gerald Ballou, Ripley Heppner, D. Gray, Jr. Heppner, D. Gray TI Heterologous prime-boost immunization with epidermal gene gun administered Plasmodium falciparum circumsporozoite protein (CSP) encoding DNA and intramuscular RTS,S/ASO2A in rhesus monkeys generates robust cutaneous delayed-type hypersensitivity responses against CSPC terminus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Walsh, Douglas S.; Lyon, Jeffrey A.; Stewart, Ann; Holland, Carolyn A.; Kolodny, Nelly; Heppner, D. Gray, Jr.; Heppner, D. Gray] Walter Reed Army Inst Res, Silver Spring, MD USA. [Gettayacamin, Montip; Pichyangkul, Sathit; Gosi, Panita; Tongtawe, Pongsri] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. [Leitner, Wolfgang W.] Natl Inst Hlth, Dermatol Branch, Bethesda, MD USA. [Cohen, Joe; Voss, Gerald; Ballou, Ripley] GlaxoSmithKline Biol, Rixensart, Belgium. RI Leitner, Wolfgang/F-5741-2011 OI Leitner, Wolfgang/0000-0003-3125-5922 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 1089 BP 359 EP 359 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001512 ER PT J AU Stewart, VA McGrath, SM Pau, MG Mettens, P Dubois, P Custers, JHHV Demoitie, MA Ophorst, O Shott, J Bayat, B Donner, MN Dubois, AC Goudsmit, J Cohen, J Heppner, DG AF Stewart, V. Ann McGrath, Shannon M. Pau, Maria Grazia Mettens, Pascal Dubois, Patrice Custers, Jerome H. H. V. Demoitie, Marie-Ange Ophorst, Olga Shott, Joseph Bayat, Babak Donner, Marie-Noelle Dubois, Arie-Claude Goudsmit, Jaap Cohen, Joe Heppner, D. Gray TI Heterologous prime-boost with adenovirus35-vectored CS and recombinant protein RTS,S/ASO1B greatly enhances immune responses to Plasmodium falciparum CS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 [Stewart, V. Ann; McGrath, Shannon M.; Shott, Joseph; Heppner, D. Gray] Walter Reed Army Inst Res, Silver Spring, MD USA. [Pau, Maria Grazia; Custers, Jerome H. H. V.; Ophorst, Olga; Goudsmit, Jaap] Crucell Holland BV, Leiden, Netherlands. [Mettens, Pascal; Dubois, Patrice; Demoitie, Marie-Ange; Bayat, Babak; Donner, Marie-Noelle; Dubois, Arie-Claude; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 SU S MA 1090 BP 360 EP 360 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA V44GA UT WOS:000202990001513 ER PT J AU Wortmann, G Hochberg, L Houng, HH Sweeney, C Zapor, M Aronson, N Weina, P Ockenhouse, CF AF Wortmann, G Hochberg, L Houng, HH Sweeney, C Zapor, M Aronson, N Weina, P Ockenhouse, CF TI Rapid identification of Leishmania complexes by a real-time PCR assay SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE-CHAIN-REACTION; CUTANEOUS LEISHMANIASIS; DIAGNOSIS; DIFFERENTIATION; PARASITES AB A real-time PCR assay for the detection of four Leishmania complexes (L. Viannia, L. mexicana, L. donovani/infantum, and L. major) was developed and evaluated. The assay was developed to detect the glucosephosphate isomerase gene and capitalizes on DNA sequence variability within that gene for Leishmania complex identification. Primer/probe sets were created and tested against a panel of 21 known negative controls and on DNA extracted from cultured promastigotes or from tissue biopsies from patients with cutaneous leishmaniasis. The assay was highly specific, as no amplification products were detected in the negative control samples while simultaneously retaining a high degree of complex-specific diagnostic accuracy for cultured organisms and patient clinical samples. Real-time PCR offers rapid (within hours) identification of Leishmania to the complex level and provides a useful molecular tool to assist both epidemiologists and clinicians. C1 Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. Walter Reed Army Inst Res, Dept Viral Dis, Silver Spring, MD USA. Uniformed Serv Univ Hlth Sci, Div Infect Dis, Bethesda, MD 20814 USA. Walter Reed Army Inst Res, Dept Expt Therapeut, Silver Spring, MD USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. RP Wortmann, G (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM glenn.wortmann@na.amedd.army.mil RI Weina, Peter/A-2120-2011 NR 27 TC 47 Z9 48 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2005 VL 73 IS 6 BP 999 EP 1004 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 998XT UT WOS:000234353900002 PM 16354801 ER PT J AU Martin, B AF Martin, B TI Sexual dysfunction in patients with allergic rhinoconjunctivitis - Guest editorial SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Editorial Material ID RHINITIS; INDEX C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Martin, B (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD DEC PY 2005 VL 95 IS 6 BP 498 EP 498 PG 1 WC Allergy; Immunology SC Allergy; Immunology GA 996KV UT WOS:000234173700004 PM 16400886 ER PT J AU Ellsworth, RE Ellsworth, DL Deyarmin, B Hoffman, LR Love, B Hooke, JA Shriver, CD AF Ellsworth, RE Ellsworth, DL Deyarmin, B Hoffman, LR Love, B Hooke, JA Shriver, CD TI Timing of critical genetic changes in human breast disease SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE allelic imbalance; atypical ductal hyperplasia; ductal carcinoma-in-situ; breast cancer; tumor progression ID CARCINOMA IN-SITU; SURGICAL ADJUVANT BREAST; DUCTAL CARCINOMA; ALLELIC LOSS; CANCER; HETEROZYGOSITY; PROGRESSION; TAMOXIFEN; RECEPTOR; RISK AB Background: Breast cancer development has been characterized as a nonobligatory sequence of histological changes from normal epithelium through invasive malignancy. Although genetic alterations are thought to accumulate stochastically during tumorigenesis, little is known about the timing of critical mutations. This study examined allelic imbalance (AI) in tissue samples representing a continuum of breast cancer development to examine the evolution of genomic instability. Methods: Laser-microdissected DNA samples were collected from histologically normal breast specimens (n = 25), atypical ductal hyperplasia (ADH, n = 16), ductal carcinoma-in-situ (DCIS, n = 37), and stage I to III invasive carcinomas (n = 72). Fifty-two microsatellite markers representing 26 chromosomal regions commonly deleted in breast cancer were used to assess patterns of AI. Results: AI frequencies were < 5% in histologically normal and ADH specimens, 20% in DCIS lesions, and approximately 25% in invasive tumors. Mann-Whitney tests showed (1) that levels of AI in ADH samples did not differ significantly from those in histologically normal tissues and (2) that AI frequencies in DCIS lesions were not significantly different from those in invasive carcinomas. ADH and DCIS samples, however, differed significantly (P < .0001). Conclusions: DCIS lesions contain levels of genomic instability that are characteristic of advanced invasive tumors, and this suggests that the biology of a developing carcinoma may already be predetermined by the in situ stage. Observations that levels of AI in ADH lesions are similar to those in disease-free tissues provide a genomic rationale for why prevention strategies at the ADH level are successful and why cases with ADH involving surgical margins do not require further resection. C1 Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. Invitrogen Bioinformat, Carlsbad, CA 92008 USA. Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. RP Ellsworth, RE (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org NR 27 TC 14 Z9 15 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD DEC PY 2005 VL 12 IS 12 BP 1054 EP 1060 DI 10.1245/ASO.2005.03.522 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA 986KK UT WOS:000233448300013 PM 16228814 ER PT J AU Guan, J Zhang, Q O'Neil, M Obaldia, N Ager, A Gerena, L Lin, AJ AF Guan, J Zhang, Q O'Neil, M Obaldia, N Ager, A Gerena, L Lin, AJ TI Antimalarial activities of new pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; FOLATE ANTAGONISTS; UNITED-STATES; OWL MONKEY; DRUGS; INVITRO; TAFENOQUINE; MEFLOQUINE; ANTIMETABOLITES; ANTIFOLATE AB WR227825 is an antimalarial pyrroloquinazolinediamine derivative with a high potency but a low therapeutic index. A series of carbamate, carboxamide, succinimide, and alkylamine derivatives of WR227825 were prepared to search for compounds with an improved therapeutic index. The new acetamides and imide showed potent cell growth inhibition against four clones of Plasmodium falciparum (D-6, RCS, W-2, and TM91C235), with a 50% inhibitory concentration of similar to 0.01 ng/ml, and were highly active against Plasmodium berghei, with 100% cure at doses from < 0.1 mg/kg of body weight to 220 mg/kg. The carbamates and alkyl derivatives, however, showed weak activity against Plasmodium falciparum cell growth but were highly efficacious in tests against P. berghei by the Thompson test. The best compounds, bis-ethylcarbamate (compound 2a) and tetra-acetamide (3a) derivatives, further demonstrated high potency against the sporozoite Plasmodium yoelii in mice and P. falciparum and Plasmodium vivax in aotus monkeys. Against the AMRU-1 strain of P. vivax, which has four dihydrofolate reductase mutations and is highly resistant to antifolates, tetra-acetamide 3a cured the monkeys at doses of 1 and 3 mg/kg. Compound 2a cured only one out of two monkeys at 3 mg/kg. The results indicated that the new derivatives 2a and 3a not only have retained/improved the antimalarial efficacy of the parent compound WR227825 but also were less toxic to the animals used in the tests. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. Trop Med Res Gorgas Mem Inst, Panama City, Panama. Univ Miami, Miami, FL 33177 USA. RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Washington, DC 20307 USA. EM ai.lin@na.amedd.army.mil RI Obaldia, Nicanor/O-8460-2015; OI Obaldia, Nicanor/0000-0002-3711-9449 NR 33 TC 30 Z9 31 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2005 VL 49 IS 12 BP 4928 EP 4933 DI 10.1128/AAC.49.12.4928-4933.2005 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 989RS UT WOS:000233692100013 PM 16304154 ER PT J AU Deziel, MR Heine, H Louie, A Kao, M Byrne, WR Basset, J Miller, L Bush, K Kelly, M Drusano, GL AF Deziel, MR Heine, H Louie, A Kao, M Byrne, WR Basset, J Miller, L Bush, K Kelly, M Drusano, GL TI Effective antimicrobial regimens for use in humans for therapy of Bacillus anthracis infections and postexposure prophylaxis SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID IN-VITRO; MODEL SYSTEM; PHARMACODYNAMICS; PREVENTION; PARAMETERS; INHIBITOR; EFFICACY; PROTEASE AB Expanded options for treatments directed against pathogens that can be used for bioterrorism are urgently needed. Treatment regimens directed against such pathogens can be identified only by using data derived from in vitro and animal studies. It is crucial that these studies reliably predict the efficacy of proposed treatments in humans. The objective of this study was to identify a levofloxacin treatment regimen that will serve as an effective therapy for Bacillus anthracis infections and postexposure prophylaxis. An in vitro hollow-fiber infection model that replicates the pharmacokinetic profile of levofloxacin observed in humans (half-life 16,211 7.5 h) or in animals, such as the mouse or the rhesus monkey (t(1/2), similar to 2 h), was used to evaluate a proposed indication for levofloxacin (500 mg once daily) for the treatment of Bacillus anthracis infections. The results obtained with the in vitro model served as the basis for the doses and the dose schedules that were evaluated in the mouse inhalational anthrax model. The effects of levofloxacin and ciprofloxacin treatment were compared to those of no treatment (untreated controls). The main outcome measure in the in vitro hollow-fiber infection model was a persistent reduction of culture density (>= 4 log(10) reduction) and prevention of the emergence of levofloxacin-resistant organisms. In the mouse inhalational anthrax model the main outcome measure was survival. The results indicated that levofloxacin given once daily with simulated human pharmacokinetics effectively sterilized Bacillus anthracis cultures. By using a simulated animal pharmacokinetic profile, a once-daily dosing regimen that provided a human-equivalent exposure failed to sterilize the cultures. Dosing regimens that "partially humanized" levofloxacin exposures within the constraints of animal pharmacokinetics reproduced the antimicrobial efficacy seen with human pharmacokinetics. In a mouse inhalational anthrax model, once-daily dosing was significantly inferior (survival end point) to regimens of dosing every 12 h or every 6 h with identical total daily levofloxacin doses. These results demonstrate the predictive value of the in vitro hollow-fiber infection model with respect to the success or the failure of treatment regimens in animals. Furthermore, the model permits the evaluation of treatment regimens that "humanize" antibiotic exposures in animal models, enhancing the confidence with which animal models may be used to reliably predict the efficacies of proposed antibiotic treatments in humans in situations (e.g., the release of pathogens as agents of bioterrorism or emerging infectious diseases) where human trials cannot be performed. A treatment regimen effective in rhesus monkeys was identified. C1 Ordway Res Inst, Albany, NY 12208 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Johnson & Johnson Pharmaceut Res & Dev LLC, Raritan, NJ USA. RP Ordway Res Inst, 150 New Scotland Ave, Albany, NY 12208 USA. EM gdrusano@ordwayresearch.org FU NIAID NIH HHS [1 PO1 AI060908-01A1, P01 AI060908] NR 30 TC 47 Z9 48 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2005 VL 49 IS 12 BP 5099 EP 5106 DI 10.1128/AAC.49.12.5099-5106.2005 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 989RS UT WOS:000233692100037 PM 16304178 ER PT J AU Thompson, KT Crocker, FH Fredrickson, HL AF Thompson, KT Crocker, FH Fredrickson, HL TI Mineralization of the cyclic nitramine explosive hexahydro-1,3,5-trinitro-1,3,5-triazine by Gordonia and Williamsia spp. SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID SP STRAIN DN22; ANAEROBIC SLUDGE; RDX HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; PHYLOGENETIC CHARACTERIZATION; CLOSTRIDIUM-BIFERMENTANS; SUBSURFACE BACTERIA; BIODEGRADATION; DEGRADATION; BIOTRANSFORMATION; RNA AB Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a cyclic nitroamine explosive that is a major component in many military high-explosive formulations. In this study, two aerobic bacteria that are capable of using RDX as the sole source of carbon and nitrogen to support their growth were isolated from surface soil. These bacterial strains were identified by their fatty acid profiles and 16S ribosomal gene sequences as Williamsia sp. KTR4 and Gordonia sp. KTR9. The physiology of each strain was characterized with respect to the rates of RDX degradation and [U-C-14]RDX mineralization when RDX was supplied as a sole carbon and nitrogen source in the presence and absence of competing carbon and nitrogen sources. Strains KTR4 and KTR9 degraded 180 mu M RDX within 72 h when RDX served as the only added carbon and nitrogen source while growing to total protein concentrations of 18.6 and 16.5 mu g/ml, respectively. Mineralization of [U-C-14]RDX to (CO2)-C-14 was 30% by strain KTR4 and 27% by KTR9 when RDX was the only added source of carbon and nitrogen. The addition of (NH4)(2)SO4 greatly inhibited KTR9's degradation of RDX but had little effect on that of KTR4. These are the first two pure bacterial cultures isolated that are able to use RDX as a sole carbon and nitrogen source. These two genera possess different physiologies with respect to RDX mineralization, and each can serve as a useful microbiological model for the study of RDX biodegradation with regard to physiology, biochemistry, and genetics. C1 USA, Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. Analyt Serv Inc, Vicksburg, MS 39180 USA. RP Thompson, KT (reprint author), USA, Army Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Karen.T.Thompson@erdc.usace.army.mil NR 45 TC 70 Z9 70 U1 2 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD DEC PY 2005 VL 71 IS 12 BP 8265 EP 8272 DI 10.1128/AEM.71.12.8265-8272.2005 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 999VB UT WOS:000234417600078 PM 16332812 ER PT J AU Kott, A Budd, R Ground, L Rebbapragada, L Langston, J AF Kott, A Budd, R Ground, L Rebbapragada, L Langston, J TI Building a tool for battle planning: Challenges, tradeoffs, and experimental findings SO APPLIED INTELLIGENCE LA English DT Article DE military decision making; planning and scheduling; experimental AI; decision aids; course of action; analysis AB Use of knowledge-based decision aids can help alleviate the challenges of planning complex operations. We describe a knowledge-based tool capable of translating a high-level concept for a tactical military operation into a fully detailed, actionable plan, producing automatically (or with human guidance) plans with realistic degree of detail and complexity. Tight interleaving of planning, adversary estimates, scheduling, routing, attrition and consumption processes comprise the computational approach of this tool. Although originally developed for Army large-unit operations, the technology is generic and also applies to a number of other domains, particularly in critical situations requiring detailed planning within a constrained period of time. In this paper, we focus particularly on the engineering tradeoffs in the design of the tool. An experimental comparative evaluation indicated that the tool's performance compared favorably with human planners. C1 BBN Technol, Arlington, VA 22209 USA. DARPA, Arlington, VA 22203 USA. Green River Associates Inc, Fredericksburg, VA USA. USA, CECOM, RDEC, Ft Monmouth, NJ 07703 USA. Austin Informat Syst, Parkville, MO 64152 USA. RP Budd, R (reprint author), BBN Technol, 1300 N 17th St,Suite 400, Arlington, VA 22209 USA. EM akott@darpa.mil; rbudd@bbn.com; larryground@earthlink.net; Lakshmi.Rebbapragada@mail1.monmouth.army.mil; langstonj7@aol.com NR 27 TC 3 Z9 4 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0924-669X J9 APPL INTELL JI Appl. Intell. PD DEC PY 2005 VL 23 IS 3 BP 165 EP 189 DI 10.1007/s10489-005-4606-z PG 25 WC Computer Science, Artificial Intelligence SC Computer Science GA 983PS UT WOS:000233245200003 ER PT J AU McLeod, MIK Christensen, R Sorensen, MP AF McLeod, MIK Christensen, R Sorensen, MP TI Pathology quiz case 2 SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material ID NODULAR FASCIITIS; REGION; NECK C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Res Inst, Bethesda, MD USA. RP McLeod, MIK (reprint author), USN, Washington, DC USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD DEC PY 2005 VL 131 IS 12 BP 1121 EP + PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 991QA UT WOS:000233827300015 ER PT J AU Scobell, A AF Scobell, A TI China's evolving civil-military relations: Creeping guojiahua SO ARMED FORCES & SOCIETY LA English DT Article AB T he People's Republic of China (PRC) is the largest and most important of a handful of communist party-states that survived the turn of the century. The PRC has endured for more than fifty years, and almost three decades have elapsed since the death in 1976 of Mao Zedong, the legendary leader of the Chinese Communist Party (CCP). The economic reforms launched by the late Deng Xiaoping in 1978 have fueled an almost uninterrupted quarter-century of sustained economic growth and prosperity in China. Most recently, since 2002, China has witnessed a sweeping turnover of party, state, and military elites: first at the 16th CCP Congress in November 2002, and then at the 10th National People's Congress in March 2003.(1) A new generation of Chinese leaders has come to the fore-the "Fourth Generation." Given these milestones, it is an appropriate time to take stock of China's evolving civil-military relations, analyze key trends, and consider implications for the future. Most experts agree that other than the CCP, the most central institution in the PRC is the People's Liberation Army (PLA). Most experts also agree that during the reform era the PLA underwent major changes. Since the late 1970s, the PLA downsized from approximately 4.5 million to approximately 2.25 million today. Moreover, the military has become a more modern force: better educated, better equipped, and more dynamic with institutionalized retirement norms, a new doctrine, and warfighting focused on "limited war under high technology conditions" replacing the outdated "people's war" scenario.(2) In efforts to make sense of all these changes, three dubious assumptions often are made about contemporary Chinese civil-military relations. First, civilian control of the military is firmly entrenched.(3) Typically, control is either believed to be exerted by firm party control of the army through the political commissar system-also known as the "penetration model"-or assured because all senior soldiers are Communist Party members and tend to function as the "party in uniform."(4) Second, and relatedly, civil-military relations in China tend to be viewed as synonymous with party-army relations.(5) Third, the predominant trends within the PLA during the reform era are seen as professionalization and depoliticization.(6) These are all questionable assumptions, and this article argues that civilian control is actually weakly institutionalized, civil-military relations encompass considerably more than just party-army ties, and increasing levels of professionalism have not been accompanied by decreasing politicization. While most analysts contend that Chinese civil-military relations are in a period of major transition, they disagree about the exact nature of the changes and what the most important trends are. Many experts believe the predominant trend since 1978 is professionalization.(7) I contend that the overriding transformation underway is creeping guojiahua (the Chinese term guojiahua can be translated as statification or nationalization). C1 USA, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. Dickinson Coll, Carlisle, PA 17013 USA. RP Scobell, A (reprint author), USA, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. NR 49 TC 2 Z9 2 U1 0 U2 5 PU TRANSACTION PERIOD CONSORTIUM PI PISCATAWAY PA RUTGERS UNIV, DEPT 8010, 35 BERRUE CIRCLE, PISCATAWAY, NJ 08854-8042 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD WIN PY 2005 VL 31 IS 2 BP 227 EP + DI 10.1177/0095327X0503100204 PG 19 WC Political Science; Sociology SC Government & Law; Sociology GA 898UB UT WOS:000227100600003 ER PT J AU Ender, MG AF Ender, MG TI Tailwind tale: Inside Vietnam's last great myth. SO ARMED FORCES & SOCIETY LA English DT Book Review C1 US Mil Acad, W Point, NY 10996 USA. RP Ender, MG (reprint author), US Mil Acad, W Point, NY 10996 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI PISCATAWAY PA RUTGERS UNIV, DEPT 8010, 35 BERRUE CIRCLE, PISCATAWAY, NJ 08854-8042 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD WIN PY 2005 VL 31 IS 2 BP 297 EP 297 DI 10.1177/0095327X0503100207 PG 1 WC Political Science; Sociology SC Government & Law; Sociology GA 898UB UT WOS:000227100600006 ER PT J AU Samet, ED AF Samet, ED TI Camp all-American, Hanoi Jane, and the high and tight: Gender, folklore, and changing military culture. SO ARMED FORCES & SOCIETY LA English DT Book Review C1 US Mil Acad, W Point, NY USA. RP Samet, ED (reprint author), US Mil Acad, W Point, NY USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI PISCATAWAY PA RUTGERS UNIV, DEPT 8010, 35 BERRUE CIRCLE, PISCATAWAY, NJ 08854-8042 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD WIN PY 2005 VL 31 IS 2 BP 315 EP 318 DI 10.1177/0095327X0503100213 PG 4 WC Political Science; Sociology SC Government & Law; Sociology GA 898UB UT WOS:000227100600014 ER PT J AU Martin, JJ AF Martin, JJ TI Tumor necrosis factor alpha inhibitors and methotrexate: Implications for deployed personnel SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE rheumatoid arthritis; psoriasis; psoriatic arthritis; etanercept; infliximab; adalimumab; operational medicine; adverse effects; laboratory monitoring ID HEART-FAILURE; RHEUMATOID-ARTHRITIS; FACTOR ANTAGONIST; THERAPY; TUBERCULOSIS; DEMYELINATION; INFLIXIMAB; INFECTION AB Rheumatic diseases such as rheumatoid and psoriatic arthritis are often diagnosed in younger age groups and are, therefore, likely to be encountered in active-duty military populations. These patients are increasingly being treated with disease modifying anti-rheumatic drugs (DMARDs) and biologic agents such as tumor necrosis factor alpha (TNF-alpha) inhibitors. While these classes of drugs have revolutionized the treatment of rheumatic diseases, they are also associated with serious potential adverse effects. At present, there are no published guidelines for the routine monitoring of laboratory parameters in patients receiving anti-TNF therapy. Currently, no official consensus among military physicians exists regarding duty and geographic limitations for patients receiving these types of therapy. Major adverse effects of these agents are reviewed in this article. A survey of U.S. Air Force, Army, and Navy rheumatologists was performed. The results of laboratory monitoring and operational deployment recommendations are reported. The majority of U.S. military rheumatologists do not recommend deployment of patients while taking methotrexate or TNF-alpha inhibitors. C1 Walter Reed Army Med Ctr, Dept Rheumatol, Washington, DC 20307 USA. RP Martin, JJ (reprint author), Walter Reed Army Med Ctr, Dept Rheumatol, 5900 Georgia Ave NW, Washington, DC 20307 USA. EM joseph.martin@amedd.army.mil NR 23 TC 0 Z9 0 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD DEC PY 2005 VL 76 IS 12 BP 1162 EP 1166 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 991BC UT WOS:000233786100011 PM 16370267 ER PT J AU Lam, DM AF Lam, DM TI The Aerochir: The first "flying hospital" SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE air evacuation; battlefield surgery; history of aviation medicine AB The concept of providing light and far-forward mobile surgical support teams to care for battle casualties is being increasingly adopted by most NATO nations as a result of military and political-economic considerations. Similar considerations led to the design of a mobile surgical hospital capable of flying a surgical team and all its equipment to a location of need as early as 1919. Unlike many of the early attempts to fuse medicine and aviation, the Nemirovsky-Tilmant Aerochir was not a dead-end. It served as a proof-of-concept product which led to the development and adoption of the Breguet "Aerochir," which was used in French colonial wars of the 1920s, and eventually led to adoption of the concept of air-mobile far-forward surgical care by many of the world's militaries. This design from over 80 yr ago, along with its creators, should be remembered and honored by those of us involved in providing aeromedical support to battlefield casualties. C1 USA, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. Univ Maryland, Sch Med, Natl Study Ctr Trauma & EMS, Baltimore, MD 21201 USA. RP Lam, DM (reprint author), PSC 79,Box 145, APO, AE 09714 USA. NR 16 TC 0 Z9 1 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD DEC PY 2005 VL 76 IS 12 BP 1174 EP 1179 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 991BC UT WOS:000233786100014 PM 16370270 ER PT J AU Syed, SA Kamimori, GH Kelly, W Eddington, ND AF Syed, SA Kamimori, GH Kelly, W Eddington, ND TI Multiple dose pharmacokinetics of caffeine administered in chewing gum to normal healthy volunteers SO BIOPHARMACEUTICS & DRUG DISPOSITION LA English DT Article DE caffeine chewing gum; caffeine multiple dose; pharmacokinetics; buccal absorption ID RELATIVE BIOAVAILABILITY; PERFORMANCE; DRUGS AB The purpose of this study was to examine the pharmacokinetics of three doses of caffeine administered as Stay Alert(R) chewing gum in a multiple dose regimen. Methods: A double-blind, parallel randomized, four-treatment study design was employed. The treatment groups were: 50, 100 and 200 mg caffeine and placebo. Subjects were 48 (n = 12 per group), healthy, non-smoking, males and females who had abstained from caffeine ingestion for at least 20 h prior to dosing, who were randomly assigned to the treatment groups. Caffeine was administered at 2400, 0200 and 0400 h depending on the treatment group. Blood samples were collected pre-dose and at 5, 15, 30, 45, 60, 75, 90 and 105 min after each caffeine dose. Samples were also collected at 7.5, 8.5 and 18 h after the last dose of caffeine. Plasma caffeine levels were analysed by a validated UV-HPLC method. Result: The mean T-max after the third dosing ranged from 0.37 to 1.12 h. C-max for 50, 100 and 200 mg was 2.69, 3.45 and 6.33 mg/l, respectively AUC(inf) for 50, 100 and 200 mg group was 33.2, 46.94 and 86.94 mg/l * h, respectively. AUC(inf) values suggested a dose proportionate increase. Dose normalized C-max and AUC(o-tau) values across doses were not significantly different, suggesting linearity was maintained after multiple doses of the Stay Alert(R) chewing gum. There were no group related differences in elimination. Conclusions: The results suggest that caffeine administered in the gum formulation (Stay Alert(R) chewing gum) via a multiple dosing regimen provides an effective and convenient means of maintaining effective concentrations of caffeine that would in some operational scenarios be desirable for maintaining alertness and performance in sleep deprived individuals. Copyright (C) 2005 John Wiley & Sons, Ltd. C1 Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Pharmacokinet & Biopharmaceut Lab, Baltimore, MD 21201 USA. Walter Reed Army Inst Res, Dept Neurobiol & Behav, Silver Spring, MD 20910 USA. RP Eddington, ND (reprint author), Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Pharmacokinet & Biopharmaceut Lab, AHB 540A,100 Penn St, Baltimore, MD 21201 USA. EM neddingt@rx.umaryland.edu NR 12 TC 21 Z9 21 U1 0 U2 5 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0142-2782 J9 BIOPHARM DRUG DISPOS JI Biopharm. Drug Dispos. PD DEC PY 2005 VL 26 IS 9 BP 403 EP 409 DI 10.1002/bdd.469 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 004CD UT WOS:000234728700003 PM 16158445 ER PT J AU Xie, D Cheng, H Hamrick, M Zhong, Q Dong, KH Correa, D Williams, S Mulloy, A Bollag, W Bollag, RJ Runner, RR McPherson, JC Insogna, K Isales, CM AF Xie, D Cheng, H Hamrick, M Zhong, Q Dong, KH Correa, D Williams, S Mulloy, A Bollag, W Bollag, RJ Runner, RR McPherson, JC Insogna, K Isales, CM TI Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover SO BONE LA English DT Article DE GIP; incretin; nutrition; hormones; gastric inhibitory peptide ID GENE-RELATED PEPTIDE; GROWTH FACTOR-I; OSTEOBLAST PROLIFERATION; HYPOTHALAMIC RELAY; CANCELLOUS BONE; CELL-CULTURES; AMYLIN; CALCITONIN; VIVO; OSTEOPOROSIS AB Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone, which is secreted from endocrine cells in the small intestine after meal ingestion. GIP has been shown to affect osteoblastic function in vitro; however, the in vivo effects of GIP on bone remodeling remain unclear. In the present study, we investigated the role of GIP in modulating bone turnover, by evaluating serum markers of bone turnover, bone density, bone morphology, and changes in biomechanical bone strength over time (one to five months) in GIP receptor knockout mice (GIPR-/- mice). The GIPR-/- mice showed a decreased bone size, lower bone mass, altered bone microarchitecture and biomechanical properties, and altered parameters for bone turnover, especially in bone formation. Moreover, the effects of GIP on bone mass were site-specific and compensatory mechanism developed over time and ameliorated the impact of the loss of GIP signaling on bone mass. Further, GIPR-/- mice had earlier age-related changes than wild-type mice in body composition, including bone mass, lean body mass, and fat percentage. In summary, our results indicate that GIP has an anabolic effect on bone mass and bone quality and suggests that GIP may be a hormonal link between nutrient ingestion and utilization. (c) 2005 Elsevier Inc. All rights reserved. C1 Med Coll Georgia, Dept Med, Inst Mol Med & Genet, Augusta, GA 30912 USA. Med Coll Georgia, Med Ctr, Augusta Vet Adm Med Ctr, Augusta, GA 30912 USA. Sun Yat Sen Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Guangzhou, Peoples R China. USA, Dept Clin Invest, Dwight D Eisenhower Med Ctr, Ft Gordon, GA 30905 USA. Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA. RP Isales, CM (reprint author), Med Coll Georgia, Dept Med, Inst Mol Med & Genet, CB-2803,1120 15th St, Augusta, GA 30912 USA. EM cisales@mail.mcg.edu RI Isales, Carlos/J-9902-2013; Hamrick, Mark/K-1131-2016 OI Isales, Carlos/0000-0002-4480-3484; FU NIAMS NIH HHS [R01AR049717]; NIDDK NIH HHS [R01DK058680] NR 38 TC 69 Z9 72 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 8756-3282 J9 BONE JI Bone PD DEC PY 2005 VL 37 IS 6 BP 759 EP 769 DI 10.1016/j.bone.2005.06.021 PG 11 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 998SW UT WOS:000234340700003 PM 16219496 ER PT J AU Subramanian, PS Miller, NR Renard, V Tamargo, RJ Miller, NR AF Subramanian, PS Miller, NR Renard, V Tamargo, RJ Miller, NR TI Delayed progressive visual loss following wrapping of bilateral clinoidal aneurysms: recovery of vision and improvement in neuroimaging during corticosteroid treatment SO BRITISH JOURNAL OF OPHTHALMOLOGY LA English DT Letter ID MUSLIN-INDUCED GRANULOMA; OF-THE-LITERATURE; INTRACRANIAL ANEURYSMS; OPTIC NEUROPATHY; MR C1 Johns Hopkins Univ Hosp, Dept Ophthalmol, Baltimore, MD 21287 USA. Johns Hopkins Univ Hosp, Dept Neurosurg, Baltimore, MD 21287 USA. RP Subramanian, PS (reprint author), Walter Reed Army Med Ctr, OPhthalmol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM prem.subramanian@na.amedd.army.mil OI Subramanian, Prem/0000-0001-5824-8322 NR 10 TC 3 Z9 3 U1 0 U2 2 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0007-1161 J9 BRIT J OPHTHALMOL JI Br. J. Ophthalmol. PD DEC PY 2005 VL 89 IS 12 BP 1666 EP 1667 DI 10.1136/bjo.2005.078626 PG 2 WC Ophthalmology SC Ophthalmology GA 985HR UT WOS:000233368700033 PM 16299157 ER PT J AU Li, DC Panchang, V Tang, ZX Demirbilek, Z Ramsden, J AF Li, DC Panchang, V Tang, ZX Demirbilek, Z Ramsden, J TI Evaluation of an approximate method for incorporating floating docks in harbor wave prediction models SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Article DE wave; model; mild slope; equation; floating breakwater; dock; marina; harbor ID BREAKWATER; SIMULATION AB Computer models based on the two-dimensional (2-D) elliptic mild-slope equation are nowadays routinely used in harbor engineering applications. However, structures like floating breakwaters and docks, which are often encountered in the modeling domain, render the problem for locally three-dimensional model and hence are problematic to incorporate in a 2-D model. Tsay and Liu (Applied Ocean Research. 1983. Vol 5(1): 30-37) proposed a highly simplified but approximate approach that does not violate the overall two dimensionality of the problem. The validity of their approach is examined in detail, and it is found that although their approximation provides results with the correct trend, the actual solutions deviate considerably from the theoretical solutions. We have developed correction factors that may be used to produce more reliable results using the framework of Tsay and Liu. Application of the resulting method to a harbor in Alaska shows that docks in the harbor distort the wave field considerably and create a reflective pattern that has the potential to affect navigation safety in some areas. A by-product of this paper consists of plots of transmission coefficients for waves propagating past rectangular and cylindrical floating objects of infinite extent for a wide range of conditions encountered in practice. Such transmission coefficients are at present readily available in the published literature for selected cases only. C1 Texas A&M Univ, Dept Maritime Syst Engn, Galveston, TX 77553 USA. USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. Parsons Brinckerhoff Quade & Douglas Inc, Ports & Marine, Portland, OR 97204 USA. RP Panchang, V (reprint author), Texas A&M Univ, Dept Maritime Syst Engn, 200 Seawolf Pkwy, Galveston, TX 77553 USA. EM panchanv@tamug.edu NR 23 TC 9 Z9 10 U1 0 U2 2 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD DEC PY 2005 VL 32 IS 6 BP 1082 EP 1092 DI 10.1139/L05-059 PG 11 WC Engineering, Civil SC Engineering GA 000PN UT WOS:000234474400007 ER PT J AU Lopez-Santalla, M Krishnan, S Valeri, AP Aguilera-Montilla, N Fisher, CU Perez-Blas, M Gutierrez-Calvo, A Lasa, I Granell-Vicent, J Tsokos, GC Martin-Villa, JM AF Lopez-Santalla, M Krishnan, S Valeri, AP Aguilera-Montilla, N Fisher, CU Perez-Blas, M Gutierrez-Calvo, A Lasa, I Granell-Vicent, J Tsokos, GC Martin-Villa, JM TI Defective CD3 zeta chain expression in Herpesvirus saimiri (HVS)-derived T-cell lines in gastric adenocarcinoma SO CELLULAR IMMUNOLOGY LA English DT Article DE CD3 zeta; T lymphocytes; gastric adenocarcinoma ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; TUMOR-INFILTRATING LYMPHOCYTES; RECEPTOR ZETA-CHAIN; SPLICED 3'-UNTRANSLATED REGION; TCR-ZETA; DOWN-REGULATION; SIGNAL-TRANSDUCTION; IMMUNE-RESPONSE; MESSENGER-RNA; CARCINOMA AB Low expression of the CD3 zeta chain has been reported in patients with cancer and it has been suggested that tumor-derived factors are involved in its downregulation. The expression of CD3 zeta chain was measured in T-cell lines from patients with gastric adenocarcinoma and healthy volunteers and grown in vitro for several months and, hence, in the absence of any tumor-derived factors. T-cell lines of mucosal origin were obtained by Herpesvirus saimiri transformation from gastric cancer patients. The expression of CD3 zeta and CD3 epsilon was measured by flow cytometry and Western-blot analysis. Calcium mobilization and apoptosis rate were also measured. The levels of CD3 zeta, but not CD3 epsilon, chain on the cell surface were significantly reduced in T-cell lines derived from patients with gastric cancer when cultured in the absence of IL-2. Western-blot analysis of total cell extracts or lipid raft fractions confirmed this finding. Calcium mobilization, a measure of signal transduction, was reduced in T cell lines from patients with gastric cancer. We conclude that T cells from patients with cancer express lower levels of CD3 zeta. This downregulation is not caused by a direct effect of tumor-derived factors but, rather, it appears to be inherent to the patient cells. The low CD3 zeta expression would render T lymphocytes unable to control the growth of tumor cells. (c) 2006 Elsevier Inc. All rights reserved. C1 Univ Complutense Madrid, Fac Med, E-28040 Madrid, Spain. Hosp Univ Principe Asturias, Serv Cirugia Gen & Aparato Digest, Alcala De Henares, Spain. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Martin-Villa, JM (reprint author), Univ Complutense Madrid, Fac Med, E-28040 Madrid, Spain. EM jmmvilla@med.ucm.es RI Martin-Villa, Jose M./F-9234-2013; Aguilera-Montilla, Noemi/G-4277-2015; Lopez-Santalla, Mercedes/L-1335-2015 OI Martin-Villa, Jose M./0000-0002-2436-8585; Aguilera-Montilla, Noemi/0000-0002-6925-6069; Lopez-Santalla, Mercedes/0000-0002-8543-8743 FU NIAID NIH HHS [R01 AI042269] NR 41 TC 6 Z9 7 U1 2 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0008-8749 J9 CELL IMMUNOL JI Cell. Immunol. PD DEC PY 2005 VL 238 IS 2 BP 113 EP 122 DI 10.1016/j.cellimm.2006.02.007 PG 10 WC Cell Biology; Immunology SC Cell Biology; Immunology GA 039CZ UT WOS:000237279300006 PM 16616055 ER PT J AU Kollef, MH Shorr, A Tabak, YP Gupta, V Liu, LZ Johannes, RS AF Kollef, MH Shorr, A Tabak, YP Gupta, V Liu, LZ Johannes, RS TI Epidemiology and outcomes of health-care-associated pneumonia - Results from a large US database of culture-positive pneumonia SO CHEST LA English DT Article DE community acquired; epidemiology; health care; mechanical ventilation; mortality; nosocomial; outcomes; pneumonia; resource use ID COMMUNITY-ACQUIRED PNEUMONIA; RESISTANT STAPHYLOCOCCUS-AUREUS; VENTILATOR-ASSOCIATED PNEUMONIA; ANTIMICROBIAL THERAPY; ADULTS; GUIDELINES; INFECTIONS; MANAGEMENT; MEDISGROUPS; BACTEREMIA AB Context: Traditionally, pneumonia developing in patients outside the hospital is categorized as community acquired, even if these patients have been receiving health care in an outpatient facility. Accumulating evidence suggests that health-care-associated infections are distinct from those that are truly community acquired. Objective: To characterize the microbiology and outcomes among patients with culture-positive community-acquired pneumonia (CAP), health-care-associated pneumonia (HCAP), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP). Design and setting: A retrospective cohort study based on a large US inpatient database. Patients: A total of 4,543 patients with culture-positive pneumonia admitted into 59 US hospitals between January 1, 2002, and December 31, 2003, and recorded in a large, multi-institutional database of US acute-care hospitals (Cardinal Health-Atlas Research Database; Cardinal Health Clinical Knowledge Services; Marlborough, MA). Main measures: Culture data (respiratory and blood), in-hospital mortality, length of hospital stay (LOS), and billed hospital charges. Results: Approximately one half of hospitalized patients with pneumonia had CAP, and > 20% had HCAP. Staphylococcus aureus was a major pathogen in all pneumonia types, with its occurrence markedly higher in the non-CAP groups than in the CAP group. Mortality rates associated with HCAP (19.8%) and HAP (18.8%) were comparable (p > 0.05), and both were significantly higher than that for CAP (10%, all p < 0.0001) and lower than that for VAP (29.3%, all p < 0.0001). Mean LOS varied significantly with pneumonia category (in order of ascending values: CAP, HCAP, HAP, and VAP; all p < 0.0001). Similarly, mean hospital charge varied significantly with pneumonia category (in order of ascending value: CAP, HCAP, HAP, and VAP; all p < 0.0001). Conclusions: The present analysis justified HCAP as a new category of pneumonia. S aureus was a major pathogen of all pneumonias with higher rates in non-CAP pneumonias. Compared with CAP, non-CAP was associated with more severe disease, higher mortality rate, greater LOS, and increased cost. C1 Washington Univ, Sch Med, Div Pulm & Crit Care, St Louis, MO 63110 USA. Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. Cardinal Hlth Clin Knowledge Serv Res Grp, Marlborough, MA USA. Pfizer Inc, New York, NY USA. RP Kollef, MH (reprint author), Washington Univ, Sch Med, Div Pulm & Crit Care, Campus Box 8052,660 S Euclid Ave, St Louis, MO 63110 USA. EM mkollef@im.wustl.edu NR 33 TC 524 Z9 549 U1 2 U2 26 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD DEC PY 2005 VL 128 IS 6 BP 3854 EP 3862 DI 10.1378/chest.128.6.3854 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 997HK UT WOS:000234235900014 PM 16354854 ER PT J AU Kortepeter, MG Lemmon, JW Moran, KA AF Kortepeter, MG Lemmon, JW Moran, KA TI A soldier with traumatic brain injury and meningitis SO CLINICAL INFECTIOUS DISEASES LA English DT Article C1 Walter Reed Army Med Ctr, Dept Pathol, Washington, DC USA. Walter Reed Army Med Ctr, Infect Dis Serv, Dept Med, Washington, DC USA. RP Kortepeter, MG (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 1114 Churchview Pl, Potomac, MD 20854 USA. EM Mark.Kortepeter@na.amedd.army.mil NR 10 TC 3 Z9 3 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD DEC 1 PY 2005 VL 41 IS 11 BP 1604 EP + PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 980KY UT WOS:000233018600009 PM 16273662 ER PT J AU Thomas, DB Brooks, DE Bice, TG DeJong, ES Lonergan, KT Wenke, JC AF Thomas, DB Brooks, DE Bice, TG DeJong, ES Lonergan, KT Wenke, JC TI Tobramycin-impregnated calcium sulfate prevents infection in contaminated wounds SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID DEMINERALIZED BONE-MATRIX; ANTIBIOTIC BEADS; OPEN FRACTURES; MANAGEMENT; DEFECTS; MODEL AB Open fractures often are associated with increased rates of infection and nonunion, multiple surgical procedures, and delayed return to preinjury activity. Antimicrobial bone graft substitutes used as an alternative to antibiotic cement beads and/or delayed autologous bone grafting may provide a useful adjunct in patients with open fractures. A stable, unicortical defect was created and contaminated with 30 mu L of 5 x 10(6) colony-forming units/mL of Staphylococcus aureus in the proximal tibial metaphysis of Spanish goats. The negative control group received no treatment, the carrier group received synthetic bone graft alone, the positive control group received tobramycin antibiotic cement, and the treatment group received tobramycin antimicrobial synthetic bone graft (calcium sulfate). After a 3-week evaluation period, intraosseous microbiologic specimens were obtained. The Staphylococcus aureus contaminant was recovered in 11 of 12 animals (mean = 6.9 x 10(7) colony-forming units/g marrow) in the negative control group and in all animals (mean = 2.2 x 10(8) colony-forming units/g marrow) in the carrier group. Bacteria were not found in the antibiotic-treated groups. The tobramycin-impregnated calcium sulfate was effective in preventing infection in a contaminated defect. It could be beneficial in reducing the number of surgeries and recovery time because it is bioabsorbable and osteoconductive. C1 Brooke Army Med Ctr, Orthopaed Surg Serv, Ft Sam Houston, TX 78234 USA. US Army Inst Surg Res, Ft Sam Houston, TX USA. RP Thomas, DB (reprint author), Brooke Army Med Ctr, Orthopaed Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM darryl.thomas2@cen.amedd.army.mil NR 23 TC 35 Z9 39 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X EI 1528-1132 J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD DEC PY 2005 IS 441 BP 366 EP 371 DI 10.1097/01.blo.0000181144.01306.b0 PG 6 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 991EI UT WOS:000233794700055 PM 16331028 ER PT J AU Lavery, JE AF Lavery, JE TI Shape-preserving interpolation of irregular data by bivariate curvature-based cubic L(1) splines in spherical coordinates SO COMPUTER AIDED GEOMETRIC DESIGN LA English DT Article DE bivariate; cubic spline; curvature; interpolation; irregular; L(1); L(2); shape preservation; spherical coordinates ID MULTIQUADRIC INTERPOLATION; MULTISCALE INTERPOLATION; SCATTERED DATA; SURFACES AB We investigate C(1)-smooth bivariate curvature-based cubic L(1) interpolating splines in spherical coordinates. The coefficients of these splines are calculated by minimizing an integral involving the L(1) norm of univariate curvature in four directions at each point on the unit sphere. We compare these curvature-based cubic L(1) splines with analogous cubic L(2) interpolating splines calculated by minimizing an integral involving the square of the L(2) norm of univariate curvature in the same four directions at each point. For two sets of irregular data on an equilateral tetrahedron with protuberances on the faces, we compare these two types of curvature-based splines with each other and with cubic L(1) and L(2) splines calculated by minimizing the L(1) norm and the square of the L(2) norm, respectively, of second derivatives. Curvature-based cubic L(1) splines preserve the shape of irregular data well, better than curvature-based cubic L(2) splines and than second-derivative-based cubic L(1) and L(2) splines. Second-derivative-based cubic L(2) splines preserve shape poorly. Variants of curvature-based L(1) and L(2) splines in spherical and general curvilinear coordinate systems are outlined. Published by Elsevier B.V. C1 USA, Res Off, Res Lab, Div Math, Res Triangle Pk, NC 27709 USA. RP Lavery, JE (reprint author), USA, Res Off, Res Lab, Div Math, POB 12211, Res Triangle Pk, NC 27709 USA. EM john.lavery2@us.army.mil NR 32 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-8396 J9 COMPUT AIDED GEOM D JI Comput. Aided Geom. Des. PD DEC PY 2005 VL 22 IS 9 BP 818 EP 837 DI 10.1016/j.cagd.2005.03.004 PG 20 WC Computer Science, Software Engineering; Mathematics, Applied SC Computer Science; Mathematics GA 982HJ UT WOS:000233148400002 ER PT J AU Valisetty, RR Chung, PW Namburu, RR AF Valisetty, RR Chung, PW Namburu, RR TI Scalable computing for the transient elasto-plastic impact analysis of composite armor using the homogenization method SO COMPUTERS & STRUCTURES LA English DT Article DE asymptotic expansion homogenization; PARADYN; high performance computing; scalable computing; impact modeling; composite modeling ID MULTISCALE PROJECTION METHOD; HETEROGENEOUS MEDIA; ASYMPTOTIC HOMOGENIZATION; WAVE-PROPAGATION; MATHEMATICAL HOMOGENIZATION; MECHANICAL-PROPERTIES; ELASTIC BEHAVIOUR; TEMPORAL SCALES; DAMAGE; MODEL AB This paper describes impact analyses of armor composites using concurrent coupling of scales through asymptotic expansion homogenization (AEH) in elasto-plastic and transient settings. The AEH method is applied with an explicit time integration algorithm for the transients and an updated Lagrangian scheme for the large displacements. The primary aim of this paper is to present numerical validations against the experiments of S. Zhuang, G. Ravichandran and D.E. Grady [An experimental investigation of shock wave propagation in periodically layered composites. J Mech Phys Solids 2003-151:245-65] and S. Zhang (Shock wave propagation in periodically layered composites, PhD thesis, California Institute of Technology, Pasadena, CA, 2002] to demonstrate the validity of the computational method for layered armor composites. A parallel computer program was developed to handle the parallel computations across multiple scales and then integrated with a widely available explicit dynamics finite element program. A brief scalability study demonstrates the computational viability of the method. Published by Elsevier Ltd. C1 USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Valisetty, RR (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. EM rama@arl.army.mil NR 49 TC 0 Z9 0 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PD DEC PY 2005 VL 84 IS 1-2 BP 49 EP 60 DI 10.1016/j.compstruc.2005.08.003 PG 12 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA 997JU UT WOS:000234242300006 ER PT J AU Schnurr, PP Friedman, MJ Engel, CC Foa, EB Shea, MT Resick, PM James, KE Chow, BK AF Schnurr, PP Friedman, MJ Engel, CC Foa, EB Shea, MT Resick, PM James, KE Chow, BK TI Issues in the design of multisite clinical trials of psychotherapy: VA Cooperative Study No. 494 as an example SO CONTEMPORARY CLINICAL TRIALS LA English DT Article DE psychotherapy research; posttraumatic stress disorder (PTSD); cognitive-behavioral therapy; women; military veterans ID POSTTRAUMATIC-STRESS-DISORDER; COGNITIVE-BEHAVIORAL THERAPY; EXPOSURE THERAPY; RANDOMIZED-TRIAL; RAPE VICTIMS; SEXUAL-ABUSE; PTSD; VETERANS; EFFICACY; COMBINATION AB This article describes issues in the design of an ongoing multisite randomized clinical trial of psychotherapy for treating posttraumatic stress disorder (PTSD) in female veterans and active duty personnel. Research aimed at testing treatments for PTSD in women who have served in the military is especially important due to the high prevalence of PTSD in this population. VA Cooperative Study 494 was designed to enroll 384 participants across 12 sites. Participants are randomly assigned to receive 10 weekly sessions of individual psychotherapy: Prolonged Exposure, a specific cognitive-behavioral therapy protocol for PTSD, or present-centered therapy, a comparison treatment that addresses current interpersonal problems but avoids a trauma focus. PTSD is the primary outcome. Additional outcomes are comorbid problems such as depression and anxiety; psychosocial function and quality of life; physical health status; satisfaction with treatment; and service utilization. Follow-up assessments are conducted at the end of treatment and then 3 and 6 months after treatment. Both treatments are delivered according to a manual. Videotapes of therapy sessions are viewed by experts who provide feedback to therapists throughout the trial to ensure adherence to the treatment manual. Discussion includes issues encountered in multisite psychotherapy trials along with the rationale for our decisions about how we addressed these issues in CSP #494. (c) 2005 Elsevier Inc. All rights reserved. C1 VA Med Ctr, Natl Ctr PTSD 116D, White River Jct, VT 05009 USA. Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Hanover, NH 03756 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Washington, DC USA. Univ Penn, Ctr Treatment & Study Anxiety, Philadelphia, PA 19104 USA. VA Med Ctr, Providence, RI USA. Boston Univ, Sch Med, Boston, MA 02118 USA. Oregon Hlth Sci Univ, Portland, OR 97201 USA. VA Cooperat Studies Program, Menlo Pk, CA USA. RP Schnurr, PP (reprint author), VA Med Ctr, Natl Ctr PTSD 116D, 215 N Main St, White River Jct, VT 05009 USA. EM Paula.Schnurr@Dartmouth.edu NR 53 TC 20 Z9 20 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1551-7144 J9 CONTEMP CLIN TRIALS JI Contemp. Clin. Trials PD DEC PY 2005 VL 26 IS 6 BP 626 EP 636 DI 10.1016/j.cct.2005.09.001 PG 11 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 995BD UT WOS:000234074000004 PM 16236558 ER PT J AU Grounds, RM Bolan, C AF Grounds, RM Bolan, C TI Clinical experiences and current evidence for therapeutic recombinant factor VIIa treatment in nontrauma settings (vol 9, pg S29, 2005) SO CRITICAL CARE LA English DT Correction C1 Univ London St Georges Hosp, Adult Intens Care Unit, London, England. USA, Med Corps, Bethesda, MD USA. NIH, Blood Serv Sect, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA. RP Grounds, RM (reprint author), Univ London St Georges Hosp, Adult Intens Care Unit, London, England. EM m.grounds@blueyonder.co.uk NR 1 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1466-609X J9 CRIT CARE JI Crit. Care PD DEC PY 2005 VL 9 IS 6 BP 560 EP 560 DI 10.1186/cc3926 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 014XR UT WOS:000235514400039 ER PT J AU Black, IH Stormo, J AF Black, IH Stormo, J TI Target controlled infusion (TCI) versus traditional infusion of nicardapine: A computer model comparison. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 35th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 07-11, 2006 CL San Francisco, CA C1 Brooke Army Med Ctr, SAUSHEC Anesthesia Residency, San Antonio, TX USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2005 VL 33 IS 12 SU S SI SI BP A172 EP A172 DI 10.1097/00003246-200512002-00607 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 000ZG UT WOS:000234500900602 ER PT J AU Morrison, CA Probst, R Collins, G Hashiro, G Ichimura, W Uyehara, C Davis, S Raymond, J AF Morrison, CA Probst, R Collins, G Hashiro, G Ichimura, W Uyehara, C Davis, S Raymond, J TI High intensity focused ultrasound treatment of a simulated missile tract injury in a rabbit model. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 35th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 07-11, 2006 CL San Francisco, CA C1 Tripler Army Med Ctr, TAMC, HI USA. Univ Mississippi, Natl Ctr Phys Acoust, University, MS 38677 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2005 VL 33 IS 12 SU S SI SI BP A34 EP A34 DI 10.1097/00003246-200512002-00125 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 000ZG UT WOS:000234500900125 ER PT J AU Ray, D Wasser, TE Ahrens, TM Taylor, RW Ahrens, TS Thomas, J Owen, C AF Ray, D Wasser, TE Ahrens, TM Taylor, RW Ahrens, TS Thomas, J Owen, C TI Validation of the Critical Care Family Satisfaction Survey by use of internet data entry. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 35th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 07-11, 2006 CL San Francisco, CA C1 Lehigh Valley Hosp, Macungie, PA USA. USA, ICU, St Louis, MO USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2005 VL 33 IS 12 SU S SI SI BP A29 EP A29 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 000ZG UT WOS:000234500900113 ER PT J AU Ray, D Wasser, TE Ahrens, TM Taylor, RW Ahrens, TS Thomas, J Owen, C AF Ray, D Wasser, TE Ahrens, TM Taylor, RW Ahrens, TS Thomas, J Owen, C TI Use of an internet based system to collect benchmarking data on ICU performance using the Critical Care Family Satisfaction Survey (CCFSS). SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 35th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 07-11, 2006 CL San Francisco, CA C1 Lehigh Valley Hosp, Macungie, PA USA. USA, ICU, St Louis, MO USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2005 VL 33 IS 12 SU S SI SI BP A29 EP A29 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 000ZG UT WOS:000234500900112 ER PT J AU Sherer, CR Price, M Lesho, E Kortepeter, M Craft, D Snow, K Fishbain, J Moran, K Hamilton, T Lindler, L Hakre, S Chung, K AF Sherer, CR Price, M Lesho, E Kortepeter, M Craft, D Snow, K Fishbain, J Moran, K Hamilton, T Lindler, L Hakre, S Chung, K TI MDR acinetobacter meningitis among us military personnel injured in Iraq SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 35th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 07-11, 2006 CL San Francisco, CA C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2005 VL 33 IS 12 SU S SI SI BP A179 EP A179 DI 10.1097/00003246-200512002-00630 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 000ZG UT WOS:000234500900625 ER PT J AU Short, A Lazarus, DR Sherner, JH Jackson, WL Morrel, M Fraser, V Kollef, MH AF Short, A Lazarus, DR Sherner, JH Jackson, WL Morrel, M Fraser, V Kollef, MH TI Inability to predict etiology in fungemia in the ICU: Implications of the prevalence of non-albicans (NA) candidemia SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 35th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 07-11, 2006 CL San Francisco, CA C1 Washington Hosp Ctr, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Barnes Jewish Hosp, St Louis, MO 63110 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2005 VL 33 IS 12 SU S SI SI BP A155 EP A155 DI 10.1097/00003246-200512002-00547 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 000ZG UT WOS:000234500900542 ER PT J AU Thurlby, JR Grathwohl, KW Perkins, JG Spinella, PC Repine, TB Beekley, A Sebesta, J Nichols, D Duval, B Blackbourne, L Black, IH Wade, CE Holcomb, JB AF Thurlby, JR Grathwohl, KW Perkins, JG Spinella, PC Repine, TB Beekley, A Sebesta, J Nichols, D Duval, B Blackbourne, L Black, IH Wade, CE Holcomb, JB TI Reduced mortality by an intensivist or intensivist directed ICU team at a combat support hospital (CSH) in Iraq. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 35th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 07-11, 2006 CL San Francisco, CA C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2005 VL 33 IS 12 SU S SI SI BP A1 EP A1 DI 10.1097/00003246-200512002-00004 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 000ZG UT WOS:000234500900005 ER PT J AU Kyttaris, VC Sfikakis, P Juang, YT Tsokos, GC AF Kyttaris, VC Sfikakis, P Juang, YT Tsokos, GC TI Gene therapy in systemic lupus erythematosus SO CURRENT GENE THERAPY LA English DT Review DE SLE; gene therapy; cytokines; cell therapy; genetics ID RESPONSE ELEMENT MODULATOR; RECEPTOR ZETA-CHAIN; INTERFERON-GAMMA RECEPTOR/IGG1; SUPPRESSES IL-2 PRODUCTION; ANTIGEN-PRESENTING CELLS; T-CELLS; AUTOIMMUNE-DISEASE; SIGNALING DEFECTS; EMERGING CONCEPTS; MURINE LUPUS AB Despite the fact that the etiopathogenesis of systemic lupus erythematosus is largely unknown, key steps in the pathophysiology of the disease have been recognized and targeted using gene therapy techniques. In animal models of lupus, gene transfer has been used to block the action of pro-inflammatory cytokines and co-stimulatory molecules leading to clinical improvement. In humans, ex vivo experiments have shown the feasibility of gene transfer in live T cells and its potential for restoring normal phenotype in T cells from patients with lupus. Still in experimental phase, gene therapy in lupus promises to correct the aberrant immunological response without the numerous side-effects of the currently used immunosuppressant medications. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Washington Hosp Ctr, Rheumatol Sect, Washington, DC 20010 USA. Univ Athens, Dept Propedeut Internal Med 1, Athens, Greece. Uniformed Serv Univ Hlth Sci, Dept Internal Med, Bethesda, MD 20814 USA. RP Tsokos, GC (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. EM gtsokos@usuhs.mil NR 52 TC 4 Z9 4 U1 0 U2 2 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1566-5232 J9 CURR GENE THER JI Curr. Gene Ther. PD DEC PY 2005 VL 5 IS 6 BP 677 EP 684 DI 10.2174/156652305774964703 PG 8 WC Genetics & Heredity SC Genetics & Heredity GA 992YO UT WOS:000233920100013 PM 16457656 ER PT J AU Geisbert, TW AF Geisbert, TW TI Emerging Viruses: Advances and Challenges SO CURRENT MOLECULAR MEDICINE LA English DT Editorial Material C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Geisbert, TW (reprint author), USA, Med Res Inst Infect Dis, MCMR-UIV,1425 Porter St, Ft Detrick, MD 21702 USA. EM tom.geisbert@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1566-5240 J9 CURR MOL MED JI Curr. Mol. Med. PD DEC PY 2005 VL 5 IS 8 BP 733 EP 734 DI 10.2174/156652405774962290 PG 2 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 992XX UT WOS:000233918400001 PM 16375708 ER PT J AU Flick, R Whitehouse, CA AF Flick, R Whitehouse, CA TI Crimean-Congo hemorrhagic fever virus SO CURRENT MOLECULAR MEDICINE LA English DT Review ID RIFT-VALLEY FEVER; POLYMERASE CHAIN-REACTION; TICK-BORNE VIRUSES; STRAND RNA VIRUSES; CLINICAL-FEATURES; REVERSE GENETICS; GOLGI RETENTION; CLONED CDNA; EXPERIMENTAL TRANSMISSION; EXPERIMENTAL-INFECTION AB Crimean-Congo hemorrhagic fever virus (CCHFV) is an important human pathogen, which is the cause of a tick-borne illness occurring in many areas of Africa, Asia, and Europe. CCHF is characterized by a sudden onset of high fever, chills, and severe headache. Other symptoms can include gastrointestinal disorders, such as nausea, vomiting, and diarrhea. In severe cases, hemorrhagic manifestations can occur and often present as large areas of ecchymosis, rather than frank bleeding. Exposure to ticks, particularly those in the genus Hyalomma, or direct contact with virus-infected animals or people are considered the major risk factors. Studies on CCHFV are impeded by the biocontainment needed for their manipulation. However, the increasing worldwide medical awareness, the enormous interest of the media in hemorrhagic fever diseases, and their potential to be used as a bioweapon, have greatly spurred on research on this important virus, as evidenced by many new developments including the development of a reverse genetics system which should greatly enhance future research,with this virus. C1 Univ Texas, Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA. USA, Med Res Inst Infect Dis, Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Flick, R (reprint author), Univ Texas, Med Branch, Dept Pathol, Ctr Biodef & Emerging Infect Dis, 301 Univ Blvd, Galveston, TX 77555 USA. EM raflick@utmb.edu NR 139 TC 30 Z9 37 U1 0 U2 10 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1566-5240 J9 CURR MOL MED JI Curr. Mol. Med. PD DEC PY 2005 VL 5 IS 8 BP 753 EP 760 DI 10.2174/156652405774962335 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 992XX UT WOS:000233918400003 PM 16375710 ER PT J AU Hensley, LE Jones, SM Feldmann, H Jahrling, PB Geisbert, TW AF Hensley, LE Jones, SM Feldmann, H Jahrling, PB Geisbert, TW TI Ebola and Marburg viruses: Pathogenesis and development of countermeasures SO CURRENT MOLECULAR MEDICINE LA English DT Review ID TUMOR-NECROSIS-FACTOR; ENDOTHELIAL-CELL MONOLAYERS; SMALL GLYCOPROTEIN SGP; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; DENDRITIC CELLS; TISSUE FACTOR; NITRIC-OXIDE; DC-SIGN; VIRION GLYCOPROTEINS AB Ebola and Marburg viruses, family Filoviridae, are among the best known examples of emerging and re-emerging pathogens. Although outbreaks have been sporadic and geographically restricted to areas of Central Africa, the hemorrhagic fevers caused by these viruses are remarkably severe and are associated with high case fatality rates often exceeding 80 percent. In addition to humans, these viruses have decimated populations of wild apes in Central Africa. Currently, there are no vaccines or effective therapies available for human use. Progress in understanding the geneses of the pathophysiological changes that make filoviral infections of humans so destructive has been slow, primarily because these viruses require special containment for safe research. However, an increasing understanding of the molecular mechanisms of filoviral pathogenesis, facilitated by the development of new tools to elucidate critical regulatory elements in the viral life cycle, is providing new targets that can be exploited for therapeutic interventions. In addition, substantial progress has been made in developing recombinant vaccines against these viruses. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB, Canada. Univ Manitoba, Dept Immunol, Winnipeg, MB R3E 0W3, Canada. Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3T 2N2, Canada. NIAID, Integrated Res Facil, NIH, Bethesda, MD 20892 USA. RP Geisbert, TW (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM tom.geisbert@amedd.army.mil NR 120 TC 26 Z9 26 U1 5 U2 27 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1566-5240 EI 1875-5666 J9 CURR MOL MED JI Curr. Mol. Med. PD DEC PY 2005 VL 5 IS 8 BP 761 EP 772 DI 10.2174/156652405774962344 PG 12 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 992XX UT WOS:000233918400004 PM 16375711 ER PT J AU Jahrling, PB Fritz, EA Hensley, LE AF Jahrling, PB Fritz, EA Hensley, LE TI Countermeasures to the bioterrorist threat of smallpox SO CURRENT MOLECULAR MEDICINE LA English DT Review ID NF-KAPPA-B; DISSEMINATED INTRAVASCULAR COAGULATION; DEPENDENT PROTEIN-KINASE; VACCINIA VIRUS; MONKEYPOX VIRUS; VARIOLA VIRUS; LETHAL MONKEYPOX; RABBITPOX VIRUS; GENE-EXPRESSION; IMMUNE EVASION AB Variola, the agent of smallpox, is a bioterrorist threat, as is monkeypox virus, which also occurs naturally in Africa. Development of countermeasures, in the form of improved vaccines, antiviral drugs, and other therapeutic strategies are a high priority. Recent advances in molecular biology and in animal model development have provided fresh insight into the virulence determinants for smallpox and the pathophysiology of disease. The complex replication cycle for orthopoxviruses, and the pivotal role for viral-specific immunomodulatory proteins which contribute to escape from immunologic surveillance, provide many unique targets for therapeutic intervention. The "toxemia" of smallpox has been elucidated in part by variola-infected primate studies which revealed the central role of apoptosis and the evolution of a cytokine storm leading to hemorrhagic diathesis, resembling fulminent "black" smallpox. This suggests a potential role for therapeutic strategies developed for septic shock, in treatment of smallpox. Drugs licensed for other viruses which share molecular targets with orthopoxviruses (e.g. Cidofovir) or cancer drugs (e.g. Gleevec and other tyrosine kinase inhibitors) have immediate application for treatment of smallpox and monkeypox and provide leads for second generation drugs with higher therapeutic indices. Recent advances in identification of virulence determinants and immune evasion genes facilitate the design of alternative vaccines to replace live vaccinia strains that are unsuitable for a large proportion of individuals in a mass immunization campaign. C1 NIAID, NIH, Bethesda, MD 20892 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Jahrling, PB (reprint author), NIAID, NIH, 6700-B Rockledge Dr, Bethesda, MD 20892 USA. EM jahrlingp@niaid.nih.gov NR 76 TC 27 Z9 28 U1 1 U2 1 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1566-5240 J9 CURR MOL MED JI Curr. Mol. Med. PD DEC PY 2005 VL 5 IS 8 BP 817 EP 826 DI 10.2174/156652405774962326 PG 10 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 992XX UT WOS:000233918400008 PM 16375715 ER PT J AU Ellis, MW Lewis, JS AF Ellis, MW Lewis, JS TI Treatment approaches for community-acquired methicillin-resistant Staphylococcus aureus infections SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Review DE CA-MRSA; methicillin-resistance MRSA; Staphylococcus aureus; treatment ID SOFT-TISSUE INFECTIONS; SKIN-STRUCTURE INFECTIONS; COMPLICATED SKIN; TRIMETHOPRIM-SULFAMETHOXAZOLE; WEEKLY DALBAVANCIN; CONTROLLED-TRIAL; UNITED-STATES; VANCOMYCIN; DAPTOMYCIN; THERAPY AB Purpose of review This review addresses therapeutic approaches to community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections, focusing on recently published data in the English-language medical literature dating from June 2004 to July 2005. Recent findings During the reviewed time period, the overall understanding of the epidemiology and virulence of community-acquired MRSA has continued to advance. This same period has also seen numerous works dealing with the newer and emerging anti-staphylococcal antimicrobial agents. Important clinical trials involving linezolid, daptomycin, tigecycline, dalbavancin, and telavancin have been completed. At the same time, owing to the cost of newer agents and the broad susceptibility pattern of community-acquired MRSA, many older antimicrobial agents (long-acting tetracyclines, fluoroquinolones, rifampin, trimethoprim-sulfamethoxazole, and clindamycin) have also been reexamined. Summary As data accumulates, the newer antimicrobial agents active against community-acquired MRSA continue to demonstrate their value. Despite the appeal and abundant publications involving newer agents, older antimicrobials certainly retain a therapeutic role. Considerable work needs to be done prospectively evaluating older agents for community-acquired MRSA disease. The most important therapeutic intervention for the majority of community-acquired MRSA infections is adequate drainage of purulent fluid collections. Antimicrobial selection for community-acquired MRSA infections should be governed by disease severity, susceptibility patterns (especially based on timely clinical specimen culture), clinical response to therapy, and cost. C1 Brooke Army Med Ctr, MDI, MCHE, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Univ Hlth Syst, Serv Pharm, San Antonio, TX USA. RP Ellis, MW (reprint author), Brooke Army Med Ctr, MDI, MCHE, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Michael.Ellis2@amedd.army.mil NR 54 TC 38 Z9 41 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD DEC PY 2005 VL 18 IS 6 BP 496 EP 501 DI 10.1097/01.qco.0000186850.54040.fc PG 6 WC Infectious Diseases SC Infectious Diseases GA 986MD UT WOS:000233452800004 PM 16258322 ER PT J AU Murray, CK Hospenthal, DR AF Murray, CK Hospenthal, DR TI Treatment of multidrug resistant Acinetobacter SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Review DE Acinetobacter baumannii-calcoaceticus complex; infection control; treatment ID VENTILATOR-ASSOCIATED PNEUMONIA; INTENSIVE-CARE-UNIT; PSEUDOMONAS-AERUGINOSA; NOSOCOMIAL PNEUMONIA; MATCHED COHORT; BAUMANNII; INFECTIONS; HOSPITALS; COLISTIN; AMPICILLIN/SULBACTAM AB Purpose of review Acinetobacter baumannii-calcoaceticus complex has become a serious nosocomial pathogen due to its persistence in the hospital environment and its broad antimicrobial resistance patterns. This review summarizes the most recent literature pertaining to the clinical management of infections with this bacteria emphasizing in-vitro antimicrobial resistance patterns and antimicrobial efficacy in animals and humans. Recent findings Although this pathogen can be associated with an elevated crude mortality, it only contributes to this mortality in a subset of high-risk patients. Determining in-vitro activity of antimicrobial agents can be problematic due to conflicting results sometimes obtained through different testing methods. There is no simple answer as to the most appropriate antimicrobial therapy secondary to lack of adequate studies. Imipenem/cilastatin, amikacin, ampicillin/sulbactam, colistin, rifampin, and tetracyclines are typically active against these bacteria. It is also not clear if combination therapy is more effective than monotherapy. In cases in which A. baumannii-calcoaceticus complex bacteria are resistant to all available agents, we have prolonged infusion times, increased drug dose, and altered route of instillation, such as nebulized therapy for pulmonary infections with mixed results. A primary goal of A. baumannii-calcoaceticus complex management should be to prevent initial colonization and subsequent infection by adequate infection control. Summary The A. baumannii-calcoaceticus complex continues to play a significant role in our healthcare systems. Prompt and adequate therapy with agents having in-vitro activity is required once it is established that the bacteria represents infection and not colonization. Aggressive infection control policies should be enforced when this pathogen is identified. C1 Brooke Army Med Ctr, MDI, MCHE, Infect Dis Serv,Dept Med, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, MDI, MCHE, Infect Dis Serv,Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Lee, H/E-7918-2010 NR 35 TC 57 Z9 61 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD DEC PY 2005 VL 18 IS 6 BP 502 EP 506 DI 10.1097/01.qco.0000185985.64759.41 PG 5 WC Infectious Diseases SC Infectious Diseases GA 986MD UT WOS:000233452800005 PM 16258323 ER PT J AU Bell, CA Patel, R AF Bell, CA Patel, R TI A real-time combined polymerase chain reaction assay for the rapid detection and differentiation of Anaplasma phagocytophilum, Ehrlichia chaffeensis, and Ehrlichia ewingii SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Ehrlichia; Anaplasma; PCR assay ID HUMAN GRANULOCYTIC EHRLICHIOSIS; HEAT-SHOCK OPERON; UNITED-STATES; PCR ASSAY; IMMUNOREACTIVE PROTEIN; PHYLOGENETIC ANALYSIS; NUCLEOTIDE-SEQUENCES; AGENT; INFECTIONS; SEROPREVALENCE AB A rapid real-time polymerase chain reaction (PCR) assay capable of the simultaneous detection and differentiation of Anaplasma phagoeytophilum, Ehrlichia chaffeensis, and Ehrlichia ewingii was developed using the LigbtCycler (TM) instrument (Roche Applied Sciences, Indianapolis, IN). The assay tar gets the operon groEL of the heat shock protein. Base pair mismatches in amplified DNA in regions of detection probe hybridization allowed organism differentiation by melting curve analysis. The analytical sensitivity was at least 10 copies per reaction. DNA extracts from 59 specimens previously confirmed positive for A. phagocytophilum (n = 37), E. chaffeensis (n = 19), or E. ewingii (n = 3) were used to evaluate the assay. All of the specimens positive for 1 of the 3 organisms by conventional PCR were likewise positive by the LightCycler (TM) method. Sensitivity and specificity were at least 100% compared with conventional PCR. This assay provides a rapid method for the detection and differentiation of the causative agents of human ehrlichiosis in the United States. (c) 2005 Elsevier Inc. All rights reserved. C1 Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Coll Med, Div Clin Microbiol, Rochester, MN 55905 USA. Mayo Clin & Mayo Fdn, Dept Med, Coll Med, Div Infect Dis, Rochester, MN 55905 USA. RP Bell, CA (reprint author), USA, Dent & Trauma Res Detachment, Great Lakes, IL 60088 USA. EM constance.bell@us.army.mil NR 40 TC 26 Z9 27 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD DEC PY 2005 VL 53 IS 4 BP 301 EP 306 DI 10.1016/j.diagmicrobio.2005.06.019 PG 6 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 003TX UT WOS:000234705600009 PM 16263231 ER PT J AU Krinitzsky, EL AF Krinitzsky, EL TI Comment on J.U. Klilgel's "Problems in the application of the SSHAC probability method for assessing earthquake hazards at Swiss nuclear power plants", in Engineering Geology, vol. 78, pp. 285-307 SO ENGINEERING GEOLOGY LA English DT Editorial Material C1 USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Krinitzsky, EL (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 5 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD DEC PY 2005 VL 82 IS 1 BP 66 EP 68 DI 10.1016/j.enggeo.2005.09.004 PG 3 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 997KG UT WOS:000234243500006 ER PT J AU Kline, RR Lassman, TC AF Kline, RR Lassman, TC TI Competing research traditions in American industry: Uncertain alliances between engineering and science at Westinghouse Electric, 1886-1935 SO ENTERPRISE & SOCIETY LA English DT Review ID UNITED-STATES; TECHNOLOGY; INNOVATION; BUSINESS; HISTORY; SYSTEM AB Westinghouse Electric opened a new research laboratory near the company's main factory in East Pittsburgh, Pennsylvania, in 1916. Located in the suburban borough of Forest Hills, the laboratory was set up to provide scientific knowledge for the older materials testing and product development laboratories at the factory. Unlike its industrial counterparts, however, the Forest Hills laboratory was dominated by a strong engineering research tradition that disrupted efforts undertaken in the 1920s and again in the 1930s to build and sustain a diversified fundamental research program. Whereas Eastman Kodak, DuPont, AT&T, and General Electric had successfully integrated fundamental research into their corporate laboratories, the Forest Hills laboratory remained the site of recurring tensions between two cultures of innovation-one based on fundamental science, the other on engineering research. Although such tensions often resulted in competing research strategies, managerial conflicts, and mismatched corporate priorities, the longstanding culture of engineering research contributed far more to Westinghouse's strategic growth than even the most advanced fundamental research. More generally, the interactions between the cultures of engineering and science that characterize the early history of industrial research at Westinghouse highlight the evolving and sometimes conflicting patterns of technological innovation and organizational change in American industry before World War 11. C1 Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14850 USA. Cornell Univ, Dept Sci & Technol Studies, Ithaca, NY 14850 USA. USA, Ctr Mil Hist, Def Acquis Hist Project, Washington, DC 20319 USA. RP Kline, RR (reprint author), Cornell Univ, Sch Elect & Comp Engn, 394 Rhodes Hall, Ithaca, NY 14850 USA. EM rrk1@cornell.edu; thomas.lassman@hqda.army.mil NR 112 TC 4 Z9 4 U1 1 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1467-2227 J9 ENTERP SOC JI Enterp. Soc PD DEC PY 2005 VL 6 IS 4 BP 601 EP 645 DI 10.1093/es/khi123 PG 45 WC Business; History Of Social Sciences SC Business & Economics; Social Sciences - Other Topics GA 986NI UT WOS:000233455900005 ER PT J AU Jenkins, TF Hewitt, AD Walsh, ME Grant, CL Ramsey, CA AF Jenkins, TF Hewitt, AD Walsh, ME Grant, CL Ramsey, CA TI Comment on "Data representativeness for risk assessment" by Rosemary Mattuck et al., 2005 SO ENVIRONMENTAL FORENSICS LA English DT Editorial Material C1 USA, Engn Res & Engn Dev Ctr, Hanover, NH USA. Univ New Hampshire, Durham, NH 03824 USA. Enviro Stat Inc, Ft Collins, CO USA. RP Jenkins, TF (reprint author), USA, Engn Res & Engn Dev Ctr, Hanover, NH USA. NR 3 TC 0 Z9 0 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1527-5922 J9 ENVIRON FORENSICS JI Environ. Forensics PD DEC PY 2005 VL 6 IS 4 BP 321 EP 323 DI 10.1080/15275920500351650 PG 3 WC Environmental Sciences SC Environmental Sciences & Ecology GA 003KZ UT WOS:000234681900002 ER PT J AU Leis, SA Engle, DM Leslie, DM Fehmi, JS AF Leis, SA Engle, DM Leslie, DM Fehmi, JS TI Effects of short- and long-term disturbance resulting from military maneuvers on vegetation and soils in a mixed prairie area SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE community dynamics; intermediate disturbance hypothesis; military disturbance; mixed-grass prairie; richness; soil carbon; vehicular tracking ID PLANT-SPECIES DIVERSITY; DETRENDED CORRESPONDENCE-ANALYSIS; TALLGRASS PRAIRIE; INTERMEDIATE DISTURBANCE; ECOSYSTEM MANAGEMENT; COMMUNITY STRUCTURE; LANDSCAPE ECOLOGY; GRASSLAND SOILS; ORGANIC-MATTER; NORTH-AMERICA AB Loss of grassland species resulting from activities such as off-road vehicle use increases the need for models that predict effects of anthropogenic disturbance. The relationship of disturbance by military training to plant species richness and composition on two soils (Foard and Lawton) in a mixed prairie area was investigated. Track cover (cover of vehicle disturbance to the soil) and soil organic carbon were selected as measures of short- and long-term disturbance, respectively. Soil and vegetation data, collected in 1-m(2) quadrats, were analyzed at three spatial scales (60, 10, and 1 m(2)). Plant species richness peaked at intermediate levels of soil organic carbon at the 10-m(2) and 1-m(2) spatial scales on both the Lawton and Foard soils, and at intermediate levels of track cover at all three spatial scales on the Foard soil. Species composition differed across the disturbance gradient on the Foard soil but not on the Lawton soil. Disturbance increased total plant species richness on the Foard soil. The authors conclude that disturbance up to intermediate levels can be used to maintain biodiversity by enriching the plant species pool. C1 Oklahoma State Univ, Dept Plant & Soil Sci, Stillwater, OK 74078 USA. Oklahoma State Univ, US Geol Survey, Oklahoma Cooperat Fish & Wildlife Res Unit, Stillwater, OK 74078 USA. USA, Construct Engn Res Lab, Ecol Proc Branch, Champaign, IL 61822 USA. RP Leis, SA (reprint author), Oklahoma State Univ, Dept Plant & Soil Sci, 368 N Agr Hall, Stillwater, OK 74078 USA. EM sherry.leis@mdc.mo.gov OI Fehmi, Jeffrey/0000-0003-0618-9740 NR 91 TC 15 Z9 17 U1 1 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD DEC PY 2005 VL 36 IS 6 BP 849 EP 861 DI 10.1007/s00267-004-0373-6 PG 13 WC Environmental Sciences SC Environmental Sciences & Ecology GA 985QC UT WOS:000233392000006 PM 16215649 ER PT J AU Bergen, BJ Nelson, WG Mackay, J Dickerson, D Jayaraman, S AF Bergen, BJ Nelson, WG Mackay, J Dickerson, D Jayaraman, S TI Environmental monitoring of remedial dredging at the New Bedford Harbor, MA, Superfund site SO ENVIRONMENTAL MONITORING AND ASSESSMENT LA English DT Article DE monitoring; New Bedford Harbor; PCB transport; remedial dredging; site-specific criteria ID CONTAMINATED SEDIMENTS; MYTILUS-EDULIS; MASSACHUSETTS; PCB; BIOACCUMULATION; CONGENERS; TOXICITY; ESTUARY; USA AB New Bedford Harbor (NBH), MA, is a Superfund site because of high polychlorinated biphenyl (PCB) concentrations in the sediment. From April 1994 to September 1995, a remedial dredging operation (termed the "Hot Spot") removed the most contaminated sediments (PCB concentrations greater than 4000 mu g/g) from the upper harbor. During remediation, a monitoring program assessed the potential environmental impacts to NBH and adjacent Buzzards Bay. The monitoring program was developed with input from federal, state, and local authorities. Site-specific decision criteria were established to assess net PCB transport, water column toxicity, and PCB bioaccumulation in blue and ribbed mussels (Mytilus edulis and Geukensia demissa, respectively). The remediation was completed without exceeding PCB net transport or acute toxicity effects specified in the decision criteria. In addition, PCB bioaccumulation in mussels during this time period was not significantly greater than pre- or post-operational measurements. The results indicated that approximately 14000 cubic yards of highly PCB contaminated sediment were permanently removed with minimal environmental effects. The lessons learned during this operation, as well as previous pilot studies at the site, will be used to make full-scale remedial efforts in NBH more efficient and environmentally protective. C1 US EPA, Off Res & Dev, Natl Hlth & Environm Effect Lab, Atlant Ecol Div, Narragansett, RI USA. USA, N Atlant Div New England Dist, Concord, MA USA. US EPA, Boston, MA USA. RP Bergen, BJ (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effect Lab, Atlant Ecol Div, 27 Tarzwell Dr, Narragansett, RI USA. EM bergen.barbara@epa.gov NR 24 TC 9 Z9 12 U1 1 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6369 J9 ENVIRON MONIT ASSESS JI Environ. Monit. Assess. PD DEC PY 2005 VL 111 IS 1-3 BP 257 EP 275 DI 10.1007/s10661-005-8223-4 PG 19 WC Environmental Sciences SC Environmental Sciences & Ecology GA 987QM UT WOS:000233532400013 PM 16311831 ER PT J AU Lee, S Baumann, K Schauer, JJ Sheesley, RJ Naeher, LP Meinardi, S Blake, DR Edgerton, ES Russell, AG Clements, M AF Lee, S Baumann, K Schauer, JJ Sheesley, RJ Naeher, LP Meinardi, S Blake, DR Edgerton, ES Russell, AG Clements, M TI Gaseous and particulate emissions from prescribed burning in Georgia SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID AIR-POLLUTION SOURCES; FINE-PARTICLE EMISSIONS; CANADIAN FOREST-FIRES; ORGANIC-COMPOUNDS; SOURCE APPORTIONMENT; UNITED-STATES; FIREPLACE COMBUSTION; ELEMENTAL CARBON; PHASE; MORTALITY AB Prescribed burning is a significant source of fine particulate matter (PM2.5) in the southeastern United States. However, limited data exist on the emission characteristics from this source. Various organic and inorganic compounds both in the gas and particle phase were measured in the emissions of prescribed burnings conducted at two pine-dominated forest areas in Georgia. The measurements of volatile organic compounds (VOCs) and PM2.5 allowed the determination of emission factors for the flaming and smoldering stages of prescribed burnings. The VOC emission factors from smoldering were distinctly higher than those from flaming except for ethene, ethyne, and organic nitrate compounds. VOC emission factors show that emissions of certain aromatic compounds and terpenes such as alpha and beta-pinenes, which are important precursors for secondary organic aerosol (SOA), are much higher from active prescribed burnings than from fireplace wood and laboratory open burning studies. Levoglucosan is the major particulate organic compound (POC) emitted for all these studies, though its emission relative to total organic carbon (mg/g OC) differs significantly. Furthermore, cholesterol, an important fingerprint for meat cooking, was observed only in our in situ study indicating a significant release from the soil and soil organisms during open burning. Source apportionment of ambient primary fine particulate OC measured at two urban receptor locations 2025 km downwind yields 74 +/- 11% during and immediately after the burns using our new in situ profile. In comparison with the previous source profile from laboratory simulations, however, this OC contribution is on average 27 +/- 5% lower. C1 Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30312 USA. Georgia Inst Technol, Sch Earth & Atmospher Sci, Atlanta, GA 30332 USA. Univ Wisconsin, Environm Sci & Technol Program, Madison, WI 53706 USA. Univ Georgia, Dept Environm Hlth Sci, Athens, GA 30602 USA. Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA. Atmospher Res & Anal Inc, Cary, NC 27513 USA. US Army, SE Reg Off, Installat Management Agcy, Ft McPherson, GA 30330 USA. RP Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30312 USA. EM kb@rti.org RI Sheesley, Rebecca/I-6655-2015; OI Sheesley, Rebecca/0000-0002-8187-0571 NR 38 TC 130 Z9 131 U1 5 U2 86 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 1 PY 2005 VL 39 IS 23 BP 9049 EP 9056 DI 10.1021/es051583l PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 989ZK UT WOS:000233712700015 PM 16382924 ER PT J AU Dworzanski, JP Snyder, AP AF Dworzanski, Jacek P. Snyder, A. Peter TI Classification and identification of bacteria using mass spectrometry-based proteomics SO EXPERT REVIEW OF PROTEOMICS LA English DT Review DE bacteria; electrospray ionization; liquid chromatography; mass spectrometry; matrix-assisted laser desorption/ionization; peptides; proteome tandem mass spectrometry; taxonomy ID ASSISTED-LASER-DESORPTION/IONIZATION; DESORPTION IONIZATION-TIME; AD-HOC-COMMITTEE; MICROORGANISM IDENTIFICATION; PROTEIN IDENTIFICATION; RAPID IDENTIFICATION; ESCHERICHIA-COLI; BACILLUS-ANTHRACIS; DATABASE SEARCH; WHOLE CELLS AB Timely classification and identification of bacteria is of vital importance in many areas of public health. Mass spectrometry-based methods provide an attractive alternative to well-established microbiologic procedures. Mass spectrometry methods can be characterized by the relatively high speed of acquiring taxonomically relevant information. Gel-free mass spectrometry proteomics techniques allow for rapid fingerprinting of bacterial proteins using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry or, for high-throughput sequencing of peptides from protease-digested cellular proteins, using mass analysis of fragments from collision-induced dissociation of peptide ions. The latter technique uses database searching of product ion mass spectra. A database contains a comprehensive list of protein sequences translated from protein-encoding open reading frames found in bacterial genomes. The results of such searches allow the assignment of experimental peptide sequences to matching theoretical bacterial proteomes. Phylogenetic profiles of sequenced peptides are then used to create a matrix of sequence-to-bacterium assignments, which are analyzed using numerical taxonomy tools. The results thereof reveal the relatedness between bacteria, and allow the taxonomic position of an investigated strain to be inferred. C1 Sci Applicat Int Corp, Aberdeen Proving Ground, MD 21010 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Dworzanski, JP (reprint author), Sci Applicat Int Corp, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM jacek.dworzanski@us.army.mil; apsnyder@apgea.army.mil NR 95 TC 44 Z9 47 U1 0 U2 13 PU FUTURE DRUGS LTD PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-9450 J9 EXPERT REV PROTEOMIC JI Expert Rev. Proteomics PD DEC PY 2005 VL 2 IS 6 BP 863 EP 878 DI 10.1586/14789450.2.6.863 PG 16 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 089YY UT WOS:000240919000013 PM 16307516 ER PT J AU Elomrani, NF Kasis, AG Tis, JE Saleh, M AF Elomrani, NF Kasis, AG Tis, JE Saleh, M TI Outcome after foot and ankle deformity correction using circular external fixation SO FOOT & ANKLE INTERNATIONAL LA English DT Article DE ankle; deformity; equinus; external fixator; foot ID RELAPSED CLUB FOOT; ILIZAROV TECHNIQUE; CALCANEUS; CHILDREN; SAFE AB Background: External fixation is the method of choice for correction of chronic severe foot and ankle deformities. We report our experience and outcomes of circular external fixation. Methods: Fifty-five patients (60 feet) were treated with circular external fixation. The mean age at surgery was 36 (range 16 to 65) years. The mean followup was 4.4 (range 1 to 10) years. The mean time spent in external fixation was 2.1 (range 1 to 12) months. Results: There were six excellent, 35 good, eight fair, and six poor results, five of which had below knee amputations. All the patients who had an amputation were treated for infected nonunion of the ankle. Conclusion: Circular external fixation was found to be an effective method for treating a variety of complex foot and ankle problems. The complications were more common in patients with infected nonunions. C1 Univ Sheffield, No Gen Hosp, Acad Univ Orthopaed, Sheffield S5 7AU, S Yorkshire, England. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Kasis, AG (reprint author), Univ Sheffield, No Gen Hosp, Acad Univ Orthopaed, Coleridge House, Sheffield S5 7AU, S Yorkshire, England. EM atakasis@aol.com NR 24 TC 6 Z9 7 U1 0 U2 0 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD DEC PY 2005 VL 26 IS 12 BP 1027 EP 1032 PG 6 WC Orthopedics SC Orthopedics GA 993AH UT WOS:000233924600005 PM 16390634 ER PT J AU Summers, RM Yao, JH Pickhardt, PJ Franaszek, M Bitter, I Brickman, D Krishna, V Choi, JR AF Summers, RM Yao, JH Pickhardt, PJ Franaszek, M Bitter, I Brickman, D Krishna, V Choi, JR TI Computed tomographic virtual colonoscopy computer-aided polyp detection in a screening population SO GASTROENTEROLOGY LA English DT Article ID CONTRAST BARIUM ENEMA; CT COLONOGRAPHY; COLORECTAL NEOPLASIA; COLONIC POLYPS; DIAGNOSIS SCHEME; PERFORMANCE; FEASIBILITY; EXPERIENCE AB Background & Aims: The sensitivity of computed tomographic (CT) virtual colonoscopy (CT colonography) for detecting polyps varies widely in recently reported large clinical trials. Our objective was to determine whether a computer program is as sensitive as optical colonoscopy for the detection of adenomatous colonic polyps on CT virtual colonoscopy. Methods: The data set was a cohort of 1186 screening patients at 3 medical centers. All patients underwent same-day virtual and optical colonoscopy. Our enhanced gold standard combined segmental unblinded optical colonoscopy and retrospective identification of precise polyp locations. The data were randomized into separate training (n = 394) and test (n = 792) sets for analysis by a computer-aided polyp detection (CAD) program. Results: For the test set, per-polyp and per-patient sensitivities for CAD were both 89.3% (25/28; 95% confidence interval, 71.8%-97.7%) for detecting retrospectively identifiable adenomatous polyps at least 1 cm in size. The false-positive rate was 2.1 (95% confidence interval, 2.0-2.2) false polyps per patient. Both carcinomas were detected by CAD at a false-positive rate of 0.7 per patient; only :1 of 2 was detected by optical colonoscopy before segmental unblinding. At both 8-mm and 10-mm adenoma size thresholds, the per-patient sensitivities of CAD were not significantly different from those of optical colonoscopy before segmental unblinding. Conclusions: The per-patient sensitivity of CT virtual colonoscopy CAD in an asymptomatic screening population is comparable to that of optical colonoscopy for adenomas 8 mm and is generalizable to new CT virtual colonoscopy data. C1 NIH, Dept Diagnost Radiol, Warren Grant Magnuson Clin Ctr, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Natl Naval Med Ctr, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Summers, RM (reprint author), NIH, Dept Diagnost Radiol, Warren Grant Magnuson Clin Ctr, Bldg 10,Room 1C660,10 Ctr Dr MSC 1182, Bethesda, MD 20892 USA. EM rms@nih.gov FU CLC NIH HHS [Z01 CL040003-03]; Intramural NIH HHS NR 54 TC 179 Z9 183 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 EI 1528-0012 J9 GASTROENTEROLOGY JI Gastroenterology PD DEC PY 2005 VL 129 IS 6 BP 1832 EP 1844 DI 10.1053/j.gastro.2005.08.054 PG 13 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 995DE UT WOS:000234079300005 PM 16344052 ER PT J AU Mitasova, H Overton, M Harmon, RS AF Mitasova, H Overton, M Harmon, RS TI Geospatial analysis of a coastal sand dune field evolution: Jockey's Ridge, North Carolina SO GEOMORPHOLOGY LA English DT Article DE DEM; sand dunes; migration rates; lidar; GIS; North Carolina ID REGULARIZED SPLINE; INTERPOLATION; TENSION AB Preservation and effective management of highly dynamic coastal features located in areas under development pressures requires in-depth understanding of their evolution. Modem geospatial technologies such as lidar, real time kinematic GPS, and three-dimensional GIS provide tools for efficient acquisition of high resolution data, geospatial analysis, feature extraction, and quantification of change. These techniques were applied to the Jockey's Ridge, North Carolina, the largest active dune field on the east coast of the United States, with the goal to quantify its deflation and rapid horizontal mignation. Digitized contours, photogrammetric, lidar and GPS point data were used to compute a multitemporal elevation model of the dune field capturing its evolution for the period of 1974-2004. In addition, peak elevation data were available for 1915 and 1953. Analysis revealed possible rapid growth of the dune complex between 1915-1953, followed by a slower rate of deflation that continues today. ne main dune peak grew from 20.1 in in 1915 to 41.8 in in 1953 and has since eroded to 21.9 in in 2004. Two of the smaller peaks within the dune complex have recently gained elevation, approaching the current height of the main dune. Steady annual rate of main peak elevation loss since 1953 suggests that increase in the number of visitors after the park was established in 1974 had little effect on the rate of dune deflation. Horizontal dune migration of 3-6 m/yr in southerly direction has carried the sand out of the park boundaries and threatened several houses. As a result, the south dune section was removed and the sand was placed at the northern end of the park to serve as a potential source. Sand fencing has been an effective management strategy for both slowing the dune migration and forcing growth in dune elevation. Understanding the causes of the current movements can point to potential solutions and suggest new perspectives on management of the dune as a tourist attraction and as a recreation site, while preserving its unique geomorphic character and dynamic behavior. (c) 2005 Elsevier B.V. All rights reserved. C1 N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA. N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. USA, Res Lab, Res Off, Res Triangle Pk, NC 27709 USA. RP Mitasova, H (reprint author), N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA. EM hmitaso@unity.ncsu.edu OI Mitasova, Helena/0000-0002-6906-3398 NR 21 TC 44 Z9 44 U1 2 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-555X J9 GEOMORPHOLOGY JI Geomorphology PD DEC PY 2005 VL 72 IS 1-4 BP 204 EP 221 DI 10.1016/j.geomorph.2005.06.001 PG 18 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 994QH UT WOS:000234045800012 ER PT J AU McBroom, JW Acs, G Rose, GS Krivak, TC Mohyeldin, A Verma, A AF McBroom, JW Acs, G Rose, GS Krivak, TC Mohyeldin, A Verma, A TI Erythropoeitin receptor function and expression in epithelial ovarian carcinoma SO GYNECOLOGIC ONCOLOGY LA English DT Article DE erythropoietin receptor; ovarian carcinoma ID RECOMBINANT-HUMAN-ERYTHROPOIETIN; PLACEBO-CONTROLLED TRIAL; QUALITY-OF-LIFE; CANCER-PATIENTS; BREAST-CANCER; EPOETIN-ALPHA; DOUBLE-BLIND; ANEMIA; CHEMOTHERAPY; MALIGNANCIES AB Objective. Our objectives were to determine if the erythropoietin receptor (EpoR) has increased expression in epithelial ovarian carcinoma, and if erythropoietin (Epo) confers malignant properties to ovarian cancer cell lines. Methods. A Western blot analysis of protein lysates from normal ovarian surface epithelial cells and ovarian cancer cell lines was performed. In addition, immunohistochemical (IHC) staining for EpoR in tissue specimens of normal, low malignant potential tumor, and epithelial ovarian carcinoma was performed. Epo effect on ovarian cancer cell lines was investigated by a cytotoxicity assay using a cell line with high (OVCAR3) and low (SKOV3) EpoR expression. Results. Western blot analysis revealed increased expression of EpoR in multiple ovarian cancer cell lines. IHC staining revealed limited EpoR expression in benign ovarian tissue and increased levels in ovarian low malignant potential (LMP) turner and carcinoma. This difference between benign ovarian tissue and carcinoma was found to be statistically significant using a quantitative scoring system. In addition, a cytotoxicity assay with paclitaxel and cisplatin revealed an attenuation of cytotoxic effects. Conclusion. Increased EpoR expression in ovarian LMP tumors and carcinoma is demonstrated by Western blot analysis and IHC staining. Furthermore, erythropoietin adversely effects sensitivity to cisplatin in the ovarian cancer cell lines. These data add to the growing body of evidence suggesting possible detrimental effects of crythropoietin. Published by Elsevier Inc. C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Honolulu, HI 96859 USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. Univ Penn, Med Ctr, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. David Grant Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Vacaville, CA 95688 USA. RP Verma, A (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. EM averma@usuhs.mil NR 30 TC 26 Z9 26 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD DEC PY 2005 VL 99 IS 3 BP 571 EP 577 DI 10.1016/j.ygyno.2005.06.038 PG 7 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 999NZ UT WOS:000234397700008 PM 16051335 ER PT J AU Trimm, RH Tuck, EJ Tuck, G Buncick, MC Kranz, M Reiner, P Temmen, MG Ashley, PR AF Trimm, RH Tuck, EJ Tuck, G Buncick, MC Kranz, M Reiner, P Temmen, MG Ashley, PR TI Dynamic MEMS-based photonic bandgap filter SO IEEE SENSORS JOURNAL LA English DT Article DE active filter; bandpass filters; microactuators; optical filter; thin films; tunable filters ID NONLINEAR PERIODIC STRUCTURES; OPTICAL-FIBER SWITCHES; GAP SOLITONS; TRANSPARENT; FABRICATION; ABSORPTION; ACTUATORS; OPERATION; MODULATOR; GRATINGS AB This paper presents the development of an integrated fast filtering system using a photonic band gap (PBG) filter and a microelectromechanical systems (MEMS) actuator. The actuator varies the air-gap thickness between two PBG stacks to vary the optical transmission of the stack. The switch is a fast, reliable, electrically driven filter that can be fully integrated with current focal plane array technologies. The filter has been developed to have "on" and "off" states in the 3-5-mu m wavelength range. The device can be easily tailored for use in other wavebands. It can be stacked to increase the on/off contrast. This MEMS/PBG filter can be hybridized into existing optical system designs, and it can also be integrated into new optical system designs. C1 AEgis Technol Grp Inc, Huntsville, AL 35806 USA. Morgan Res Corp, Huntsville, AL 35805 USA. USA, Aviat & Missile Command, Redstone Arsenal, AL 35898 USA. RP Trimm, RH (reprint author), AEgis Technol Grp Inc, Huntsville, AL 35806 USA. EM rtrimm@aegistg.com; etuck@aegistg.co; gtuck@aegistg.com; mbuncick@aegistg.com; mkranz@morganres.com; preiner@morganres.com; mark.temmen@rdec.redstone.army.mil; paul.ashley@rdec.redstone.army.mil NR 55 TC 3 Z9 3 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD DEC PY 2005 VL 5 IS 6 BP 1451 EP 1461 DI 10.1109/JSEN.2005.858895 PG 11 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 986AF UT WOS:000233420000037 ER PT J AU Kwon, H Nasrabadi, NM AF Kwon, H Nasrabadi, NM TI Kernel orthogonal subspace projection for hyperspectral signal classification SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE kernel; nonlinear detection; orthogonal subspace projection; target detection ID SUPPORT VECTOR MACHINES; ALGORITHMS; REDUCTION; DETECTOR; IMAGERY; MODELS AB In this paper, a kernel-based nonlinear version of the orthogonal subspace projection (OSP) operator is defined in terms of kernel functions. Input data are implicitly mapped into a high-dimensional kernel feature space by a nonlinear mapping, which is associated with a kernel function. The OSP expression is then derived in the feature space, which is kernelized in terms of the kernel functions in order to avoid explicit computation in the high-dimensional feature space. The resulting kernelized OSP algorithm is equivalent to a nonlinear OSP in the original input space. Experimental results are presented for detection of roads, roof tops, mines, and targets in hyperspectral imagery, and it is shown that the kernelized OSP method outperforms the conventional OSP approach. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Kwon, H (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM hkwon@arl.army.mil; nnasraba@arl.army.mil NR 32 TC 46 Z9 54 U1 2 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD DEC PY 2005 VL 43 IS 12 BP 2952 EP 2962 DI 10.1109/TGRS.2005.857904 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 986VY UT WOS:000233479000027 ER PT J AU Orr, N Katz, DE Atsmon, J Radu, P Yavzori, M Halperin, T Sela, T Kayouf, R Klein, Z Ambar, R Cohen, D Wolf, MK Venkatesan, MM Hale, TL AF Orr, N Katz, DE Atsmon, J Radu, P Yavzori, M Halperin, T Sela, T Kayouf, R Klein, Z Ambar, R Cohen, D Wolf, MK Venkatesan, MM Hale, TL TI Community-based safety, immunogenicity, and transmissibility study of the Shigella sonnei WRSS1 vaccine in Israeli volunteers SO INFECTION AND IMMUNITY LA English DT Article ID IMMUNOGLOBULIN-A; FLEXNERI; INFECTIONS; STRAIN; IDENTIFICATION; CONSTRUCTION; ENTEROTOXIN; MECHANISMS; ACTIN; MODEL AB We describe the first community-based evaluation of Shigella sonnei strain WRSSI, a live, oral candidate vaccine attenuated by a 212-bp deletion in the virG (or icsA) plasmid virulence gene. Three single-dose regimens of WRSSI (5 X 10(3) CFU, 2 X 10(4) CFU, and 4 X 10(5) CFU) were tested with cohorts of 15 adult volunteers. The vaccine was generally well tolerated at the 10(3)- and 10(4)-CFU doses. There were no fevers and there was one report of moderate diarrhea in 30 vaccinees; five additional vaccinees reported mild diarrhea. At the 10(5)-CFU dose, there were two reports of low-grade fevers and four reports of moderate diarrhea. The geometric means for immunoglobulin A (IgA) antibody-secreting cells (ASC) against lipopolysaccharide (LPS) were 30, 75, and 193 ASC per 10(6) peripheral blood mononuclear cells (PBMC) for the 10(3)-, 10(4)-, and 10(5)-CFU doses, respectively. The IgG means were 40, 46, and 135 ASC per 10(6) PBMC, respectively. The 10(4)-CFU dose of WRSS1 gave the best balance of safety and immunogenicity, since all vaccinees had a significant IgA ASC response and 73% had a response of more than 50 ASC. The anti-LPS seroconversion rate (threefold) for IgA was 60% and the IgG rate was 27% for the 10(4)-CFU cohort. Each vaccinee and a cohabitating household contact delivered daily perianal stool swabs for bacteriological culture. WRSSI colonized vaccinees for a median of 5 days, and one individual excreted WRSS1 intermittently for 23 days. None of the 45 household contacts were colonized with WRSSI after a cumulative 192 days of cohabitation with colonized vaccinees, suggesting that adventitious vaccine spread was not common in the community setting. C1 Walter Reed Army Inst Res, Dept Enter Infect, Silver Spring, MD 20910 USA. Israel Def Forces Med Corps, Ctr Vaccine Dev & Evaluat, Tel Aviv, Israel. Tel Aviv Sourasky Med Ctr, Clin Res Ctr, Tel Aviv, Israel. Tel Aviv Univ, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel. RP Hale, TL (reprint author), Walter Reed Army Inst Res, Dept Enter Infect, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Thomas.Hale@na.amedd.army.mil NR 22 TC 34 Z9 34 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2005 VL 73 IS 12 BP 8027 EP 8032 DI 10.1128/IAI.73.12.8027-8032.2005 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 986WK UT WOS:000233480200029 PM 16299296 ER PT J AU Gu, ZF Januszkiewicz, AJ Mayorga, MA Coleman, GD Morrissette, CR AF Gu, ZF Januszkiewicz, AJ Mayorga, MA Coleman, GD Morrissette, CR TI Consequences of brief exposure to high concentrations of carbon monoxide in conscious rats SO INHALATION TOXICOLOGY LA English DT Article ID CARBOXYHEMOGLOBIN FORMATION; BLOOD CARBOXYHEMOGLOBIN; COMBUSTION TOXICOLOGY; VENTILATORY RESPONSE; HYDROGEN-CYANIDE; RESEARCH AVENUES; ANIMAL-MODELS; HUMANS; GASES; CO AB Exposure to high-concentration carbon monoxide (CO) is of concern in military operations. Experimentally, the physiologic manifestations of a brief exposure to elevated levels of CO have not been fully described. This study investigated the development of acute CO poisoning in conscious male Sprague-Dawley rats (220-380 g). Animals were randomly grouped (n = 6) and exposed to either air or 1 of 6 CO concentrations (1000, 3000, 6000, 10,000, 12,000, or 24,000 ppm) in a continuous air/CO dynamic exposure chamber for 5 min. Respiration was recorded prior to and during exposures. Mixed blood carboxyhemoglobin (COHb) and pH were measured before and immediately after exposure. Before exposure the mean baselines of respiratory minute volumes (RMVs) were 312.6 +/- 43.9, 275.2 +/- 40.8, and 302.3 +/- 39.1 ml/min for the 10,000, 12,000 and 24,000 ppm groups, respectively. In the last minute of exposure RMVs were 118.9 +/- 23.7, 62.1 +/- 10.4, and 22.0 +/- 15.1% (p < .05) of their mean baselines in these 3 groups, respectively. Immediately after exposure, blood COHb saturations were elevated to 60.16, 63.42, and 69.37%, and blood pH levels were reduced to 7.43 +/- 0.09, 7.25 +/- 0.05, and 7.13 +/- 0.04 in the 3 groups, respectively. Mortality during exposure was 1/12 in the 12,000 ppm group and 4/12 in the 24,000 ppm group. Deaths occurred close to the end of 5 min exposure. In each animal that died by exposure, pH was <6.87 and COHb saturation was >82%. Blood pH was unaltered and no death occurred in rats exposed to CO at concentrations <6000 ppm, although COHb saturations were elevated to 14.52, 29.94, and 57.24% in the 1000, 3000, and 6000 ppm groups, respectively. These results suggest that brief exposure to CO at concentrations <10,000 ppm may produce some significant physiological changes. However, exposure to CO at concentrations >10,000 ppm for brief periods as short as 5 min may change RMV, resulting in acute respiratory failure, acidemia, and even death. C1 Walter Reed Army Inst Res, Dept Resp Res, Div Mil Casualty Res, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. Walter Reed Army Inst Res, Div Biometr, Silver Spring, MD USA. RP Gu, ZF (reprint author), Walter Reed Army Inst Res, Dept Resp Res, Div Mil Casualty Res, Bldg 503,Room 1E09,Robert Grant Ave, Silver Spring, MD 20910 USA. EM zengfa.gu@na.amedd.army.mil NR 59 TC 2 Z9 3 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0895-8378 J9 INHAL TOXICOL JI Inhal. Toxicol. PD DEC 1 PY 2005 VL 17 IS 13 BP 755 EP 764 DI 10.1080/08958370500224904 PG 10 WC Toxicology SC Toxicology GA 977MO UT WOS:000232808100007 PM 16195211 ER PT J AU Scheffler, DR AF Scheffler, DR TI Modeling non-eroding perforation of an oblique aluminum target using the Eulerian CTH hydrocode SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article; Proceedings Paper CT 5th International Symposium on Impact Engineering CY JUL 12-15, 2004 CL Cambridge, ENGLAND DE numerical simulation; Eulerian methods; impact; hydrocode; penetration; projectile; target; modeling ID PENETRATION; PLATES AB In the past, Eulerian hydrocodes were not able to treat rigid body penetration/perforation problems very well. This was attributed to several factors. Velocities are defined either at the cell faces or cell corners, and all other flow-field variables are defined at the cell center. The implication is that materials in a mixed cell (cells containing more than one material) have the same velocity field and are therefore treated as welded or bonded so that sliding does not occur. Additionally, one strength is defined for a mixed cell so that in a cell containing both a hard and a soft material, the hard material can more easily deform since its strength is some average of the hard and soft material. To overcome these deficiencies, a boundary layer interface algorithm for sliding interfaces (BLINT) model was incorporated into the Eulerian CTH hydrocode for two-dimensional problems only. The BLINT model has been extended to three dimensions in later versions of the CTH hydrocode. This paper examines the ability of the CTH hydrocode, using the three-dimensional (3-D) BLINT model, to predict the experimental results in which a non-eroding projectile perforates an oblique aluminum target. The experiments consisted of a hemispherical nose 4340 steel penetrator with a length of 88.9 mm and a diameter of 12.9 min perforating a 26.3 mm thick 6061-T651 aluminum plate at 30 degrees obliquity and a nominal impact velocity of 400 m/s. Hydrocode predictions are compared to the experimental results. Strengths and weaknesses of the 3-D BLINT model are discussed. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, ATTN, AMSRD,ARL,WM,TC, Aberdeen Proving Ground, MD 21005 USA. RP Scheffler, DR (reprint author), USA, Res Lab, ATTN, AMSRD,ARL,WM,TC, Aberdeen Proving Ground, MD 21005 USA. EM scheffle@arl.army.mil NR 27 TC 3 Z9 8 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2005 VL 32 IS 1-4 BP 461 EP 472 DI 10.1016/j.ijimpeng.2005.04.008 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 993SR UT WOS:000233975800028 ER PT J AU Edison, J Finger, DR AF Edison, J Finger, DR TI Neuropathic osteoarthropathy of the shoulder SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY LA English DT Article ID ARTHROPATHY C1 Munson Army Hlth Ctr, Dept Internal Med, Ft Leavenworth, KS USA. Tripler Army Med Ctr, Dept Med, Rheumatol Serv, Honolulu, HI USA. RP Edison, J (reprint author), 811 Highview Court, Lansing, KS 66043 USA. EM jess.edison@us.army.mil NR 7 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 1076-1608 J9 JCR-J CLIN RHEUMATOL JI JCR-J. Clin. Rheumatol. PD DEC PY 2005 VL 11 IS 6 BP 333 EP 334 DI 10.1097/01.rhu.0000191148.48254.55 PG 2 WC Rheumatology SC Rheumatology GA 998VX UT WOS:000234349100011 PM 16371807 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI The uncivil war: Irregular warfare in the upper South, 1861-1865. SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD DEC PY 2005 VL 92 IS 3 BP 995 EP 996 PG 2 WC History SC History GA 082JI UT WOS:000240382300064 ER PT J AU Kanel, GI Razorenov, SV Savinykh, AS Rajendran, A Chen, Z AF Kanel, GI Razorenov, SV Savinykh, AS Rajendran, A Chen, Z TI A study of the failure wave phenomenon in glasses compressed at different levels SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB Shock-wave experiments are performed with four different kinds of glasses of different hardness compressed at different levels. The experiments with the glass specimens consisting of layered thin plates confirm the appearance of a failure wave in elastically compressed soda lime glass, heavy flint glass, K8 crown glass, and fused quartz, although the relationships between the Hugoniot elastic limits and the failure thresholds of these glasses are different. The failure wave process could occur as the stress grows above the failure threshold up to the stress level at which plastic deformation starts. The propagation speed of the failure wave in soda lime glass depends on the stress above the failure threshold, and does not depend on the propagation distance. The failure process becomes unstable and stops at the stress level near the failure threshold. Evidence of internal friction in glass within the elastic deformation region is observed. (c) 2005 American Institute of Physics. C1 IVTAN, Inst High Energy Dens, Moscow 125412, Russia. Inst Prob Chem Phys, Moscow 142432, Russia. USA, Res Off, Res Triangle Pk, NC 27709 USA. Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. RP Kanel, GI (reprint author), IVTAN, Inst High Energy Dens, Izhorskaya 13-19, Moscow 125412, Russia. RI Kanel, Gennady/K-1657-2013; Razorenov, Sergei/O-6450-2014 NR 13 TC 13 Z9 13 U1 1 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 1 PY 2005 VL 98 IS 11 AR 113523 DI 10.1063/1.2139829 PG 7 WC Physics, Applied SC Physics GA 995QT UT WOS:000234119600034 ER PT J AU Miller, BM Bartholomew, JB Springer, BA AF Miller, BM Bartholomew, JB Springer, BA TI Post-exercise affect: The effect of mode preference SO JOURNAL OF APPLIED SPORT PSYCHOLOGY LA English DT Article ID ACTIVITY ENJOYMENT SCALE; PHYSICAL-ACTIVITY; AEROBIC EXERCISE; STATE ANXIETY; MOOD; REDUCTION; STRESS; YOGA AB It has been suggested that the performance of preferred modes of exercise will serve to maximize the affective response to exercise. Support has come from work that has shown the effect of exercise on affect to be mediated by enjoyment. However, there is a need to compare modes of exercise that differ in preference and enjoyment, yet are similar in intensity, duration and muscle group. This experiment was designed to achieve this aim. Thirty-four college-aged women completed 20 minutes of exercise on high and low preference modes of continuous exercise. Intensity was maintained at 65-75% of HRR. Affect was measured by the PANAS, collected prior to and at 5, 20, and 40 min post exercise. Results provided partial support for the hypothesis as mode preference moderated the improvement in positive affect, with no effect on the reduction in negative affect. Interestingly, regardless of mode preference, enjoyment ratings were found to mediate the change in both positive and negative affect. C1 Oklahoma State Univ, Stillwater, OK 74078 USA. Univ Texas, Austin, TX 78712 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Bartholomew, JB (reprint author), Dept Kinesiol & Hlth Educ, 222 Bellmont Hall, Austin, TX 78712 USA. EM john.bart@mail.utexas.edu NR 29 TC 11 Z9 11 U1 1 U2 14 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1041-3200 J9 J APPL SPORT PSYCHOL JI J. Appl. Sport Psychol. PD DEC PY 2005 VL 17 IS 4 BP 263 EP 272 DI 10.1080/10413200500313503 PG 10 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA 986UM UT WOS:000233475200001 ER PT J AU Wang, L Li, J March, JC Valdes, JJ Bentley, WE AF Wang, L Li, J March, JC Valdes, JJ Bentley, WE TI luxS-Dependent gene regulation in Escherichia coli K-12 revealed by genomic expression profiling SO JOURNAL OF BACTERIOLOGY LA English DT Article ID QUORUM-SENSING SIGNAL; SALMONELLA-TYPHIMURIUM; BIOFILM FORMATION; CLOSTRIDIUM-PERFRINGENS; STREPTOCOCCUS-MUTANS; MICROARRAY ANALYSIS; BETA-GALACTOSIDASE; EPITHELIAL-CELLS; VIBRIO-CHOLERAE; METR PROTEIN AB The bacterial quorum-sensing autoinducer 2 (AI-2) has received intense interest because the gene for its synthase, luxS, is common among a large number of bacterial species. We have identified luxS-controlled genes in Escherichia coli under two different growth conditions using DNA microarrays. Twenty-three genes were affected by luxS deletion in the presence of glucose, and 63 genes were influenced by luxS deletion in the absence of glucose. Minimal overlap among these gene sets suggests the role of luxS is condition dependent. Under the latter condition, the metE gene, the lsrACDBFG operon, and the flanking genes of the lsr operon (lsrR, lsrK, tam, and yneE) were among the most significantly induced genes by luxS. The E. coli lsr operon includes an additional gene, tam, encoding an S-adenosyl-L-methionine-dependent methyltransferase. Also, lsrR and lsrK belong to the same operon, lsrRK, which is positively regulated by the cyclic AMP receptor protein and negatively regulated by LsrR. lsrK is additionally transcribed by a promoter between lsrR and lsrK. Deletion of luxS was also shown to affect genes involved in methionine biosynthesis, methyl transfer reactions, iron uptake, and utilization of carbon. It was surprising, however, that so few genes were affected by luxS deletion in this E. coli K-12 strain under these conditions. Most of the highly induced genes are related to AI-2 production and transport. These data are consistent with the function of LuxS as an important metabolic enzyme but appear not to support the role of AI-2 as a true signal molecule for E. coli W3110 under the investigated conditions. C1 Univ Maryland, Maryland Biotechnol Inst, Ctr Biosyst Res, College Pk, MD 20742 USA. Univ Maryland, Dept Mol Genet & Cell Biol, College Pk, MD 20742 USA. Univ Maryland, Dept Chem Engn, College Pk, MD 20742 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Bentley, WE (reprint author), Univ Maryland, Maryland Biotechnol Inst, Ctr Biosyst Res, College Pk, MD 20742 USA. EM bentley@eng.umd.edu NR 57 TC 79 Z9 83 U1 1 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD DEC PY 2005 VL 187 IS 24 BP 8350 EP 8360 DI 10.1128/JB.187.24.8350-8360.2005 PG 11 WC Microbiology SC Microbiology GA 992JK UT WOS:000233880000017 PM 16321939 ER PT J AU Wiseman, FL AF Wiseman, FL TI Monitoring the rate of solvolytic decomposition of benzenediazonium tetrafluoroborate in aqueous media using a pH electrode SO JOURNAL OF CHEMICAL EDUCATION LA English DT Article C1 US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Wiseman, FL (reprint author), ENSCO Inc, 4849 N Wickham Rd, Melbourne, FL 32940 USA. EM Wiseman.floyd@ensco.com NR 2 TC 3 Z9 3 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD DEC PY 2005 VL 82 IS 12 BP 1841 EP 1841 PG 1 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA 984VU UT WOS:000233334400027 ER PT J AU Yeo, FE Bohen, EM Yuan, CM Sawyers, ES Abbott, KC AF Yeo, FE Bohen, EM Yuan, CM Sawyers, ES Abbott, KC TI Therapeutic plasma exchange as a nephrological procedure: A single-center experience SO JOURNAL OF CLINICAL APHERESIS LA English DT Article DE plasmapheresis; thrombotic thrombocytopenic purpura; multiple mycloma; complications; death; neurologic disease ID STIFF-MAN SYNDROME; INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY; THROMBOTIC THROMBOCYTOPENIC PURPURA; INTRAVENOUS IMMUNOGLOBULIN; PERSON SYNDROME; COMPLICATIONS; APHERESIS; PLASMAPHERESIS AB in the United States, therapeutic Plasma exchange (TPE) is both performed and requested by a wide range of services, often on an empiric basis (before a diagnosis is established). Whether empiric therapy is beneficial has not been established. Patients were identified from an electronic procedure log that included those patients who received plasmapheresis at Walter Reed Army Medical Center from 1996 to 2003. The clinical indications, referring service, and outcomes (including deaths) that occurred were tabulated. Between March 1997 and August 2003, 568 TPE treatments were performed in 54 patients. The majority of the diagnoses were either neurologic (48%) or hematologic (37%). Thirty-three patients (61%) received TPE for a Category I indication. Twelve cases were performed empirically (without an established diagnosis) at the request of the referring service, most (7) performed for presumed thrombotic thrombocytopenic purpura (TTP). Almost 80% of patients required central venous catheters for treatment. Twelve patients (22%) experienced a major complication including death, and six patients (11%) died. Of the patients who died, 5 (83%) were treated empirically versus one death (17%) among patients not treated empirically, P < 0.001 by Chi Square. Only one of the seven patients treated empirically for TTP died, however. In logistic regression analysis, empiric treatment was the only factor independently associated with death, adjusted odds ratio, 34.2, 95% CI, 3.4, 334.8, P = 0.003. The most common indication for TPE was neurological disease, which also accounted for the highest proportion of complications. With the exception of presumed TTP, performing TPE in the absence of a confirmed diagnosis was not beneficial. C1 Walter Reed Army Med Ctr, Dialysis Nephrol Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Natl Naval Med Res Inst, Serv Nephrol, Bethesda, MD USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Dialysis Nephrol Serv, Washington, DC 20307 USA. EM Kevin.abbott@na.amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 29 TC 10 Z9 10 U1 0 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0733-2459 J9 J CLIN APHERESIS JI J. Clin. Apheresis PD DEC PY 2005 VL 20 IS 4 BP 208 EP 216 DI 10.1002/jca.20059 PG 9 WC Hematology SC Hematology GA 996PZ UT WOS:000234187800002 PM 16035100 ER PT J AU Berger, AC Sigurdson, ER LeVoyer, T Hanlon, A Mayer, RJ Macdonald, JS Catalano, PJ Haller, DG AF Berger, AC Sigurdson, ER LeVoyer, T Hanlon, A Mayer, RJ Macdonald, JS Catalano, PJ Haller, DG TI Colon cancer survival is associated with decreasing ratio of metastatic to examined lymph nodes SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article; Proceedings Paper CT 58th Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 03-06, 2005 CL Atlanta, GA SP Soc Surg Oncol ID GASTRIC-CARCINOMA; NUMBER; IMPACT AB Purpose Colorectal cancer is the second leading cause of cancer deaths in the United States, with poor survival predicted by regional lymph node (LN) metastasis. The impact of LN ratio (LNR) on survival is unknown in this disease. Patients and Methods We analyzed data from Intergroup trial 0089 of adjuvant chemotherapy for stage II and III patients with colon cancer, in which all patients received fluorouracil-based therapy. Survival was similar for all arms of the study, allowing us to evaluate all patients together. End points included overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS). Multivariate analyses were performed on all patients and on groups according to LNR quartiles (LNR: < 0.05, 0.05 to 0.19, 0.2 to 0.39, and 0.4 to 1.0). Covariates included in the models were age, sex, tumor stage, grade, histology, number of positive LNs, number of LNs removed, and LNR. Results The median age was 63.7 years, and the median number of LNs removed was 11. In the multivariate analysis, LNR was a significant factor for OS, DFS, and CSS in patients with 10 to 15 LN and more than 15 LN removed but not for patients with less than 10 LN removed. Using quartiles, LNR maintained its significance for all three end points when patients were grouped by node status. Conclusion After curative resection for colorectal cancer, the LNR is an important prognostic factor and should be used in stratification schemes for future clinical trials investigating adjuvant treatments. C1 Thomas Jefferson Univ, Dept Surg, Philadelphia, PA 19107 USA. Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. Eastern Cooperat Oncol Grp, Philadelphia, PA USA. Brooke Army Med Ctr, Houston, TX USA. Dept Surg Oncol, Canc & Leukemia Grp B, Chicago, IL USA. SW Oncol Grp, Ann Arbor, MI USA. RP Sigurdson, ER (reprint author), Dept Surg Oncol, 333 Cottman Ave, Philadelphia, PA 19111 USA. EM E_Sigurdson@fccc.edu NR 16 TC 288 Z9 300 U1 0 U2 9 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD DEC 1 PY 2005 VL 23 IS 34 BP 8706 EP 8712 DI 10.1200/JCO.2005.028852 PG 7 WC Oncology SC Oncology GA 989RA UT WOS:000233690200023 PM 16314630 ER PT J AU McKoy, JM Lyons, EA Obadina, E Carson, K Pickard, AS Schellhammer, P McLeod, D Boyd, CE McWilliams, N Sartor, O Schumock, GT McCaffery, K Bennett, CL AF McKoy, JM Lyons, EA Obadina, E Carson, K Pickard, AS Schellhammer, P McLeod, D Boyd, CE McWilliams, N Sartor, O Schumock, GT McCaffery, K Bennett, CL TI Caveat medicus: Consequences of federal investigations of marketing activities of pharmaceutical suppliers of prostate cancer drugs SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article AB In the course of recent health care fraud investigations against TAP Pharmaceuticals (Lake Forest, IL) and AstraZeneca International (London, United Kingdom), each pled guilty to one violation of the Prescription Drug Marketing Act, settled claims related to alleged violations of the False Claims Act without admitting guilt, and paid fines, settlements for liabilities, and reimbursements of $850 million and $355 million, respectively. In a unique aspect of these cases, federal investigators brought criminal charges against 14 TAP employees and investigated the billing practices of several urologists. These investigations resulted in guilty pleas from both urologists and industry employees relative to the Prescription Drug Marketing Act or the False Claims Act and probationary sentences with payments of fines and restitution to the government for urologists who cooperated with federal investigations. One uncooperative urologist was found guilty of violating the Federal False Claims Act and sentenced to 6 months of home arrest, excluded from Medicare for 5 years, required to provide 600 hours of free medical care to indigent patients and patients covered by Medicare or Medicaid, and paid fines and restitution to the government. The cases against TAP and AstraZeneca have been followed by federal and state investigations of allegedly illegal marketing practices of other pharmaceutical firms and have resulted in negotiated settlements of $3.8 billion and $71.5 million, respectively. Believing that an Average Wholesale Price-based reimbursement system was an important driving factor for these marketing activities, Medicare has shifted to an Average Sales Price-based reimbursement system. This is expected to greatly impact the practice of outpatient oncology nationwide. C1 Northwestern Univ, Feinberg Sch Med, Jesse Brown Vet Affairs Med Ctr, Div Gen Internal Med,Dept Med, Chicago, IL 60611 USA. Northwestern Univ, Feinberg Sch Med, Jesse Brown Vet Affairs Med Ctr, Lakeside Community Outpatient Clin, Chicago, IL 60611 USA. Northwestern Univ, Feinberg Sch Med, Jesse Brown Vet Affairs Med Ctr, Mid West Ctr Hlth Serv & Policy Res, Chicago, IL 60611 USA. Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. Northwestern Univ, Feinberg Sch Med, Div Geriatr Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. Northwestern Univ, Feinberg Sch Med, Inst Hlth Serv Res Policy, Chicago, IL 60611 USA. Univ Illinois, Coll Pharm, Rush Med Coll, Chicago, IL 60680 USA. Univ Illinois, Coll Pharm, Ctr Pharmacoecon Res, Chicago, IL 60680 USA. Louisiana State Univ, Sch Med, Dept Urol, Stanley Scott Canc Ctr, New Orleans, LA 70112 USA. Walter Reed Army Med Ctr, Urol Oncol Clin, Washington, DC 20307 USA. Eastern Virginia Med Sch, Virginia Prostate Ctr, Norfolk, VA 23501 USA. RP Bennett, CL (reprint author), Northwestern Univ, Feinberg Sch Med, Jesse Brown Vet Affairs Med Ctr, Div Gen Internal Med,Dept Med, 333 E Huron St,Ste 277, Chicago, IL 60611 USA. EM cbenne@northwestern.edu RI Bennett, Charles/C-2050-2008 FU NCI NIH HHS [1R01CA 102713-01, P 30 CA60553] NR 37 TC 7 Z9 7 U1 0 U2 3 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD DEC 1 PY 2005 VL 23 IS 34 BP 8894 EP 8905 DI 10.1200/JCO.2005.01.4605 PG 12 WC Oncology SC Oncology GA 989RA UT WOS:000233690200046 PM 16314650 ER PT J AU Thom, RM Williams, G Borde, A Southard, J Sargeant, S Woodruff, D Laufle, JC Glasoe, S AF Thom, RM Williams, G Borde, A Southard, J Sargeant, S Woodruff, D Laufle, JC Glasoe, S TI Adaptively addressing uncertainty in estuarine and near coastal restoration projects SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE adaptive management; estuarine restoration; seagrass restoration; coastal ecosystem restoration ID EELGRASS ZOSTERA-MARINA; MANAGEMENT; OREGON; MODEL AB Restoration projects have an uncertain outcome because of a lack of information about current site conditions, historical disturbance levels, effects of landscape alterations on site development, unpredictable trajectories or patterns of ecosystem structural development, and many other factors. Because of these uncertainties, project costs can rise dramatically in an attempt to come closer to project goals. All of the potential sources of error can be addressed to a certain degree through adaptive management. The first step is admitting that these uncertainties can exist, and addressing as many of the uncertainties with planning and directed research prior to implementing the project. The second step is to evaluate uncertainties through hypothesis-driven experiments during project implementation. The third step is to use the monitoring program to evaluate and adjust the project as needed to improve the probability that the project will reach its goal. The fourth and final step is to use the information gained in the project to improve future projects. A framework that includes a clear goal statement, a conceptual model, and an evaluation framework can help in this adaptive restoration process. Projects and programs vary in their application of adaptive management in restoration, and it is very difficult to be highly prescriptive in applying adaptive management to projects that necessarily vary widely in scope, goal, ecosystem characteristics, and uncertainties. One project, which included directed research and site assessments, resulted in successful restoration of seagrasses near a ferry terminal in Puget Sound and illustrates how an adaptive management process can assist in improving the outcome of small projects. We recommended that all restoration programs be conducted in an adaptive management framework, and where appropriate, a more active adaptive management approach be applied. C1 Battelle Marine Sci Lab, Sequim, WA 98382 USA. USA, Corps Engineers, Environm Resources Sect, Seattle Dist, Seattle, WA 98124 USA. Puget Sound Act Team, Olympia, WA 98504 USA. RP Thom, RM (reprint author), Battelle Marine Sci Lab, 1529 W Sequim Bay Rd, Sequim, WA 98382 USA. NR 30 TC 6 Z9 6 U1 0 U2 11 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 2005 SI 40 BP 94 EP 108 PG 15 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 908LA UT WOS:000227787300008 ER PT J AU Shorr, AF Jackson, WL AF Shorr, AF Jackson, WL TI Deep vein thrombosis in the intensive care unit: underappreciated, understudied, and undertreated SO JOURNAL OF CRITICAL CARE LA English DT Editorial Material ID CRITICALLY-ILL; SEVERE SEPSIS; PNEUMONIA C1 Washington Hosp Ctr, Pulm & Crit Care Med Serv, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Surg Crit Care Serv, Washington, DC 20010 USA. RP Shorr, AF (reprint author), Washington Hosp Ctr, Pulm & Crit Care Med Serv, Washington, DC 20010 USA. EM afshorr@dnamail.com NR 12 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0883-9441 J9 J CRIT CARE JI J. Crit. Care PD DEC PY 2005 VL 20 IS 4 BP 301 EP 303 DI 10.1016/j.jcrc.2005.08.003 PG 3 WC Critical Care Medicine SC General & Internal Medicine GA 997CT UT WOS:000234223300001 PM 16310597 ER PT J AU Leung, KP Crowe, TD Abercrombie, JJ Molina, CM Bradshaw, CJ Jensen, CL Luo, Q Thompson, GA AF Leung, KP Crowe, TD Abercrombie, JJ Molina, CM Bradshaw, CJ Jensen, CL Luo, Q Thompson, GA TI Control of oral biofilm formation by an antimicrobial decapeptide SO JOURNAL OF DENTAL RESEARCH LA English DT Article DE oral biofilms; salivary bacteria; antimicrobial peptide; dual-flow cell; surface-active agent ID PERIODONTAL-DISEASE; INNATE IMMUNITY; DENTAL PLAQUE; PEPTIDES; DEFENSINS; AGENTS; MODEL AB Oral biofilms are mixed- species microbial communities, and their uncontrolled outgrowth can express as oral diseases. Antimicrobial peptides represent alternative classes of antimicrobials that exhibit selectivity for prokaryotes. We wanted to test the effect of a synthetic decapeptide antimicrobial, KSL, on the development of oral biofilms formed by isolated human salivary bacteria. We used differential interference contrast microscopy, coupled with a dual- flow cell system, to determine the effect of KSL on oral biofilm development. We used reductions of viable counts and confocal microscopy to assess the bactericidal activity of KSL on mature oral biofilms. KSL effectively blocked biofilm development. A significant effect on the viability of mature biofilms was observed when KSL was used in the presence of a surface-active agent, or after biofilms were mechanically disrupted. This study shows that KSL may be a useful adjunct for conventional oral hygiene to prevent plaque- mediated dental diseases. C1 USA, Walter Reed Army Inst Res, Dent & Trauma Res Detachment, Microbiol Branch, Great Lakes, IL 60088 USA. USA, Walter Reed Army Inst Res, Dent & Trauma Res Detachment, Biomat Branch, Great Lakes, IL 60088 USA. RP Leung, KP (reprint author), USA, Walter Reed Army Inst Res, Dent & Trauma Res Detachment, Microbiol Branch, Great Lakes, IL 60088 USA. EM kai.leung@us.army.mil NR 23 TC 29 Z9 32 U1 1 U2 6 PU INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R PI ALEXANDRIA PA 1619 DUKE ST, ALEXANDRIA, VA 22314-3406 USA SN 0022-0345 J9 J DENT RES JI J. Dent. Res. PD DEC PY 2005 VL 84 IS 12 BP 1172 EP 1177 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 986LX UT WOS:000233452200017 PM 16304449 ER PT J AU Yang, PC Prater, JT Liu, W Glass, JT Davis, RF AF Yang, PC Prater, JT Liu, W Glass, JT Davis, RF TI The formation of epitaxial hexagonal boron nitride on nickel substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE boron nitride (BN); epitaxial; precipitation ID TRANSMISSION ELECTRON-MICROSCOPY; ORIENTED DIAMOND FILMS; THIN-FILMS; HETEROEPITAXIAL NUCLEATION; DEPOSITION; GROWTH; TRANSFORMATION; BOMBARDMENT; STRESS; ENERGY AB The various crystallographic forms of boron nitride (BN) are of great technological interest because of their demonstrated tribological, high-temperature, thermally conducting, electrically insulating, and wide-bandgap semiconductor properties. Unfortunately, the synthesis of crystalline BN films is still in the early stages of development. Furthermore, although polycrystalline BN films have been prepared by a variety of physical and chemical vapor deposition techniques, the capability does not currently exist for depositing large area single-crystal or oriented films of BN. Such single-crystal films are required for many applications of interest, especially in electronics. The present paper reports on a new approach to the oriented growth of boron nitride using a novel molten layer epitaxy technique. Well-oriented hexagonal boron nitride (h-BN) crystals were obtained with highly faceted crystal shapes. The h-BN was formed via precipitation from a molten, hydrogen-saturated Ni surface layer. Solid cubic BN was utilized as the source material and was dissolved into the substrate surface during a brief high-temperature anneal. It was found that surface melting occurred during this process and the B diffused into the Ni substrate, whereas the N was expelled into the growth chamber. Oriented BN was then precipitated as the surface layer was allowed to resolidify. C1 USA, Res Off, Div Sci Mat, Res Triangle Pk, NC 27709 USA. Duke Univ, Sch Engn, Durham, NC 27708 USA. N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Yang, PC (reprint author), 1851 W Armstrong Way, Chandler, AZ 85248 USA. EM jtglass@duke.edu RI Glass, Jeffrey/A-2266-2010; Davis, Robert/A-9376-2011 OI Glass, Jeffrey/0000-0002-9554-4398; Davis, Robert/0000-0002-4437-0885 NR 28 TC 8 Z9 8 U1 5 U2 42 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD DEC PY 2005 VL 34 IS 12 BP 1558 EP 1564 DI 10.1007/s11664-005-0165-7 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 995WH UT WOS:000234134800016 ER PT J AU Bowen, JL Salerno, SM Chamberlain, JK Eckstrom, E Chen, HL Brandenburg, S AF Bowen, JL Salerno, SM Chamberlain, JK Eckstrom, E Chen, HL Brandenburg, S TI Changing habits of practice - Transforming internal medicine residency education in ambulatory settings SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Article DE ambulatory; graduate medical education; curriculum; faculty development; internal medicine ID PRIMARY-CARE MEDICINE; NATIONAL-SURVEY; PATIENT SATISFACTION; EVALUATION EXERCISE; DOMESTIC VIOLENCE; PRACTICE PATTERNS; PHYSICIANS VIEWS; MORNING REPORT; WOMENS HEALTH; PROGRAMS AB PURPOSE: The majority of health care, both for acute and chronic conditions, is delivered in the ambulatory setting. Despite repeated proposals for change, the majority of internal medicine residency training still occurs in the inpatient setting. Substantial changes in ambulatory education are needed to correct the current imbalance. To assist educators and policy makers in this process, this paper reviews the literature on ambulatory education and makes recommendations for change. METHODS: The authors searched the Medline, Psychlit, and ERIC databases from 2000 to 2004 for studies that focused specifically on curriculum, teaching, and evaluation of internal medicine residents in the ambulatory setting to update previous reviews. Studies had to contain primary data and were reviewed for methodological rigor and relevance. RESULTS: Fifty-five studies met criteria for review. Thirty-five of the studies focused on specific curricular areas and 11 on ambulatory teaching methods. Five involved evaluating performance and 4 focused on structural issues. No study evaluated the overall effectiveness of ambulatory training or investigated the effects of current resident continuity clinic microsystems on education. CONCLUSION., This updated review continues to identify key deficiencies in ambulatory training curriculum and faculty skills. The authors make several recommendations: (1) Make training in the ambulatory setting a priority. (2) Address systems problems in practice environments. (3) Create learning experiences appropriate to the resident's level of development. (4) Teach and evaluate in the examination room. (5) Expand subspecialty-based training to the ambulatory setting. (6) Make faculty development a priority. (7) Create and fund multimstitutional educational research consortia. C1 Oregon Hlth Sci Univ, Dept Med, Div Gen Internal Med & Geriatr, Portland, OR 97239 USA. USUHS, Tripler Army Med Ctr, Honolulu, HI USA. Tripler Army Med Ctr, Internal Med Residency, Honolulu, HI 96859 USA. Univ Rochester, Sch Med, Dept Med & Pediat, Rochester, NY USA. Legacy Hlth Syst, Dept Internal Med, Portland, OR USA. Oregon Hlth Sci Univ, Dept Med, Portland, OR 97201 USA. Univ Calif San Francisco, Vet Affairs Med Ctr, San Francisco, CA 94143 USA. Univ Colorado, Hlth Sci Ctr, Div Gen Internal Med, Denver, CO 80202 USA. RP Bowen, JL (reprint author), Oregon Hlth Sci Univ, Dept Med, Div Gen Internal Med & Geriatr, 3181 SW Sam Jackson Pk Rd,L-475, Portland, OR 97239 USA. EM bowenj@ohsu.edu NR 75 TC 34 Z9 35 U1 2 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD DEC PY 2005 VL 20 IS 12 BP 1181 EP 1187 DI 10.1111/j.1525-1497.2005.0248.x PG 7 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 997OG UT WOS:000234254700019 PM 16423112 ER PT J AU Ahmed, AA McFalls, JM Hoffmann, C Filone, CM Stewart, SM Paragas, J Khodjaev, S Shermukhamedova, D Schmaljohn, CS Doms, RW Bertolotti-Ciarlet, A AF Ahmed, AA McFalls, JM Hoffmann, C Filone, CM Stewart, SM Paragas, J Khodjaev, S Shermukhamedova, D Schmaljohn, CS Doms, RW Bertolotti-Ciarlet, A TI Presence of broadly reactive and group-specific neutralizing epitopes on newly described isolates of Crimean-Congo hemorrhagic fever virus SO JOURNAL OF GENERAL VIROLOGY LA English DT Article ID MULTIPLE SEQUENCE ALIGNMENT; RIFT-VALLEY FEVER; M-RNA SEGMENT; UUKUNIEMI VIRUS; MEMBRANE GLYCOPROTEIN; CYTOPLASMIC TAIL; GOLGI RETENTION; CLUSTAL-X; LOCALIZATION; STRAINS AB Crimean-Congo hemorrhagic fever virus (CCHFV), a member of the genus Nairovirus of the family Bunyaviridae, causes severe disease in humans with high rates of mortality. The virus has a tripartite genome composed of a small (S), a medium (M) and a large Q RNA segment; the M segment encodes the two viral glycoproteins, G(N) and G(C). Whilst relatively few full-length M segment sequences are available, it is apparent that both G(N) and G(C) may exhibit significant sequence diversity. It is unknown whether considerable antigenic differences exist between divergent CCHFV strains, or whether there are conserved neutralizing epitopes. The M segments derived from viral isolates of a human case of CCHF in South Africa (SPU 41/84), an infected tick (Hyalomma marginatum) in South Africa (SPU 128/81), a human case in Congo (UG 3010), an infected individual in Uzbekistan (U2-2-002) and an infected tick (Hyalomma asiaticum) in China (Hy13) were sequenced fully, and the glycoproteins were expressed. These novel sequences showed high variability in the N-terminal region of G(N) and more modest differences in the remainder of G(N) and in G(C). Phylogenetic analyses placed these newly identified strains in three of the four previously described M segment groups. Studies with a panel of mAbs specific to G(N) and Gc indicated that there were significant antigenic differences between the M segment groups, although several neutralizing epitopes in both G(N) and G(C) were conserved among all strains examined. Thus, the genetic diversity exhibited by CCHFV strains results in significant antigenic differences that will need to be taken into consideration for vaccine development. C1 Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA. USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. Minist Hlth, Inst Virol, Tashkent, Uzbekistan. RP Bertolotti-Ciarlet, A (reprint author), Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA. EM aciarlet@mail.med.upenn.edu RI Hoffmann, Christian/C-1298-2015; OI Hoffmann, Christian/0000-0003-1736-8007; Filone, Claire Marie/0000-0002-4041-3948 FU NIAID NIH HHS [T32 AI055400, R21-AI-063308] NR 40 TC 21 Z9 25 U1 0 U2 4 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD DEC PY 2005 VL 86 BP 3327 EP 3336 DI 10.1099/vir.0.81175-0 PN 12 PG 10 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA 988VE UT WOS:000233628400016 PM 16298978 ER PT J AU Ahmed, S AF Ahmed, S TI Mathematical formulation and validation of a mixed finite element-finite difference model for simulating phreatic surfaces SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID POROUS-MEDIA; WATER-FLOW; PARABOLIC PROBLEMS; NUMERICAL-MODEL; TRANSPORT; GROUNDWATER; EQUATION; SOILS AB The phreatic surface in an unconfined aquifer exists as a movable interface between the saturated and unsaturated zones. The movement of the phreatic surface depends on recharge, hydraulic conductivity, porosity, and horizontal and vertical flows. The location of the phreatic surface helps define the variably saturated flow domain in the subsurface. The variably saturated flow process in the subsurface is described by a parabolic partial differential equation. In this equation, the hydraulic conductivity and soil moisture capacity are used as the subsurface characteristics. The location of the phreatic surface is governed by a first-order partial differential equation. The governing parabolic partial differential equation is solved using a variational finite element formulation. The first order phreatic surface equation is then solved by loosely coupling with the governing parabolic partial differential equation describing the variably saturated flow. In the present study, a two-dimensional space is used to investigate the movement of the phreatic surface in a variably saturated unconfined flow domain. Based on the time-varying solutions of hydraulic heads, the location of the phreatic surface is simulated in a finite two-dimensional space. C1 USA, Corps Engineers, Jacksonville, FL 32207 USA. RP Ahmed, S (reprint author), USA, Corps Engineers, 701 San Marco Blvd, Jacksonville, FL 32207 USA. EM shabbir.ahmed@saj02.usace.army.mil NR 28 TC 1 Z9 1 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD DEC PY 2005 VL 131 IS 12 BP 1098 EP 1105 DI 10.1061/(ASCE)0733-9429(2005)131:12(1098) PG 8 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 986VA UT WOS:000233476600008 ER PT J AU Dye, HA Kauffman, LH AF Dye, HA Kauffman, LH TI Virtual knot diagrams and the Witten-Reshetikhin-Turaev invariant SO JOURNAL OF KNOT THEORY AND ITS RAMIFICATIONS LA English DT Article DE virtual knots; invariants of 3-manifolds ID QUANTUM GROUPS AB The Witten-Reshetikhin-Turaev invariant of classical link diagrams is generalized to virtual link diagrams. This invariant is unchanged by the framed Reidemeister moves and the Kirby calculus. As a result, it is also an invariant of the 3-manifolds represented by the classical link diagrams. This generalization is used to demonstrate that there are virtual knot diagrams with a non-trivial Witten-Reshetikhin-Turaev invariant and trivial 3-manifold fundamental group. C1 US Mil Acad, MADN MATH, West Point, NY 10996 USA. Univ Illinois, Dept Math Stat & Comp Sci, Chicago, IL 60607 USA. RP Dye, HA (reprint author), US Mil Acad, MADN MATH, 646 Swift Rd, West Point, NY 10996 USA. EM hdye@ttocs.org; kauffman@uic.edu NR 18 TC 7 Z9 7 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0218-2165 J9 J KNOT THEOR RAMIF JI J. Knot Theory Ramifications PD DEC PY 2005 VL 14 IS 8 BP 1045 EP 1075 DI 10.1142/S021821650500424X PG 31 WC Mathematics SC Mathematics GA 009WA UT WOS:000235142900006 ER PT J AU Rushing, EJ Olsen, C Mena, H Rueda, ME Lee, YS Keating, RF Packer, RJ Santi, M AF Rushing, EJ Olsen, C Mena, H Rueda, ME Lee, YS Keating, RF Packer, RJ Santi, M TI Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients SO JOURNAL OF NEUROSURGERY LA English DT Article DE Gorlin syndrome; meningioma; neurofibromatosis; radiotherapy; pediatric neurosurgery ID CLEAR-CELL MENINGIOMA; RADIATION-INDUCED MENINGIOMAS; INTRACRANIAL MENINGIOMAS; MENINGEAL TUMORS; MULTIPLE MENINGIOMAS; PEDIATRIC POPULATION; CHORDOID MENINGIOMA; CHILDREN; CHILDHOOD; IRRADIATION AB Object. The occurrence of meningiomas in children younger than 20 years of age is rare, accounting for less than 3% of all childhood tumors of the central nervous system. The authors of this study sought to add to the limited available information regarding clinicopathological factors that influence outcome, disease progression, and survival in children with meningiomas. Methods. Eighty-seven cases of childhood meningiomas were identified and classified according to World Health Organization (WHO) 2000 criteria. In addition to the WHO classification, the following potential prognostic factors were analyzed: age, sex, extent of resection, history of radiotherapy, diagnosis of neurofibromatosis Type 2 (NF2) or other inherited syndromes, and the presence of a comorbidity. There was a sex predilection for male patients (35 females and 52 males). Patient age ranged from 5 months to 20 years (mean 14 years). The most common clinical presentations were seizures (33%), headaches (13%), ataxia (10%), and hemiparesis (10%). Nine patients had NF2 and two had Gorlin syndrome. Seven patients had undergone radiotherapy for a prior neoplasm. Tumor location was supratentorial in 64% of the patients, infratentorial in 16%, intraventricular in 12%, and spinal in 8%. Fifty-three patients (62%) underwent gross-total resection and 28 (33%) underwent subtotal resection. Histopathological analysis revealed 62 (71%) WHO Grade 1, 21 (24%) Grade 11, and four (5%) Grade III meningiomas. One patient received adjuvant chemotherapy and four received radiotherapy. Conclusions. Using survival data from this unique patient cohort, the authors found that recurrence-free survival time was significantly related to WHO grade (p = 0.002), but overall survival time was not significantly linked to any of the potential prognostic factors considered in this study (p = 0.06). C1 Armed Forces Inst Pathol, Dept Neuropathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Childrens Natl Med Ctr, Div Neurosurg, Washington, DC USA. Childrens Natl Med Ctr, Div Neurol, Washington, DC USA. Childrens Natl Med Ctr, Div Pediat, Washington, DC USA. Childrens Natl Med Ctr, Div Pathol, Washington, DC USA. George Washington Univ, Dept Pediat, Washington, DC 20052 USA. George Washington Univ, Dept Neurol, Washington, DC USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD USA. Catholic Univ Rome, Seoul, South Korea. RP Rushing, EJ (reprint author), Armed Forces Inst Pathol, Dept Neuropathol, Washington, DC 20306 USA. EM rushinge@afip.osd.mil NR 46 TC 49 Z9 51 U1 1 U2 5 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 USA SN 0022-3085 J9 J NEUROSURG JI J. Neurosurg. PD DEC PY 2005 VL 103 IS 6 SU S BP 489 EP 495 PG 7 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 993SA UT WOS:000233974000003 PM 16383246 ER PT J AU Brandt, HE AF Brandt, HE TI Conclusive eavesdropping in quantum key distribution SO JOURNAL OF OPTICS B-QUANTUM AND SEMICLASSICAL OPTICS LA English DT Article; Proceedings Paper CT 9th International Conference on Squeezed States and Unicertainty Relations (ICSSUR 05) CY MAY 02-06, 2005 CL Besancon, FRANCE DE quantum cryptography; quantum key distribution; quantum communication; quantum computer; entanglement ID OPERATOR-VALUED MEASURE; CRYPTOGRAPHY; INFORMATION AB It is argued that the BB84 (Bennett-Brassard 1984) protocol of quantum key distribution has a vulnerability similar to the well-known vulnerability of the B92 (Bennett 1992) protocol in the presence of losses. The quantum circuit and design are first reviewed for an optimized entangling probe attacking the BB84 protocol of quantum key distribution and yielding maximum information to the probe. Probe photon polarization states become optimally entangled with the signal states on their way between the legitimate transmitter and receiver. Although, standard von Neumann projective measurements of the probe yield maximum information on the pre-privacy amplified key, if instead the probe measurements are performed with a certain positive operator valued measure, then the measurement results are unambiguous, at least some of the time, resulting in complete information gain by the probe for sufficient loss in the key distribution channel. C1 US Army Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), US Army Res Lab, Adelphi, MD USA. EM hbrandt@arl.army.mil NR 21 TC 3 Z9 3 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1464-4266 J9 J OPT B-QUANTUM S O JI J. Opt. B-Quantum Semicl. Opt. PD DEC PY 2005 VL 7 IS 12 BP S553 EP S556 DI 10.1088/1464-4266/7/12/017 PG 4 WC Optics; Physics, Applied SC Optics; Physics GA 998NV UT WOS:000234326600018 ER PT J AU Piva, SR Goodnite, EA Childs, JD AF Piva, SR Goodnite, EA Childs, JD TI Strength around the hip and flexibility of soft tissues in individuals with and without patellofemoral pain syndrome SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE ankle plantar flexors; anterior knee pain; case control hip abduction; hip external rotation ID ANTERIOR KNEE PAIN; RELIABILITY; RESPONSIVENESS; VALIDITY; SUBTALAR; JOINT; KINEMATICS; RUNNERS; ANKLE AB Study Design: Case control design. Objectives: To investigate whether differences exist in lower extremity muscle strength and soft tissue length between patients with patellofemoral pain syndrome (PFPS) and age- and gender-matched control subjects. Background: Based on our clinical experience and emerging data, impairments such as muscular weakness surrounding the hip and limited flexibility of key lower extremity muscles may be important impairments to consider in the conservative management of PFPS. Methods and Measures: Thirty patients with PFPS and 30 age- and gender-matched controls without PFPS (17 females and 13 males in each group) participated in the study. Data were collected during 1 testing session by an examiner not blinded to group assignment. Demographic, health history, physical activity levels, and pain and function were assessed using patient-completed measures. Physical examination measures included assessment of hip external rotation strength, hip abduction strength, length of the iliotibial band/tensor fascia lata complex, gastrocnemius length, soleus length, and quadriceps and hamstrings muscles length. Results: Patients with PFPS demonstrated significantly less flexibility of the gastrocnemius, soleus, quadriceps, and hamstrings compared to healthy control subjects. No differences existed in flexibility or the iliotibial band/tensor fascia lata complex and strength of the hip external rotators and abductors. Multivariate stepwise discriminant analysis identified gastrocnemius length, hip abduction strength, and soleus length as being able to distinguish between patients with PFPS and healthy individuals without PFPS. Conclusion: This study suggests that further research is warranted regarding the association of these impairments of muscle strength and soft tissue length in patients with PFPS. C1 Univ Pittsburgh, Dept Phys Therapy, Sch Hlth & Rehabil Sci, Pittsburgh, PA 15260 USA. Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. RP Piva, SR (reprint author), Univ Pittsburgh, Dept Phys Therapy, Sch Hlth & Rehabil Sci, 6035 Forbes Tower, Pittsburgh, PA 15260 USA. EM srpst24@pitt.edu NR 37 TC 90 Z9 101 U1 2 U2 18 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD DEC PY 2005 VL 35 IS 12 BP 793 EP 801 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 994DJ UT WOS:000234010300003 PM 16848100 ER PT J AU Ender, MG Gibson, AA AF Ender, MG Gibson, AA TI Invisible institution: The military, war, and peace in pre-9/11 introductory sociology textbooks SO JOURNAL OF POLITICAL & MILITARY SOCIOLOGY LA English DT Article; Proceedings Paper CT 97th Annual Meeting of the American-Sociological-Association CY AUG 15-19, 2002 CL CHICAGO, IL SP Amer Sociol Assoc ID SOCIAL-PROBLEM; EDUCATION; DISCIPLINE; ISSUES; TEXTS; CORE; GAP AB War, peace, and the military are relatively invisible in introductory sociology textbooks immediately prior to September 11, 2001. Assuming a civilian knowledge gap on matters military, this study reports on the content of introductory textbooks for core sociological knowledge on war, peace, and the military. A content analysis exposes a variety of common concepts (N=167), primary and secondary references (N=385), and photographs (N=146) in 31 introductory sociology texts. Four thematic findings are discussed marginalization of peace, war, and military topics in textbooks; lack of conceptual and reference continuity across textbooks; prominence of photographs of peace, war, and the military themes; and perpetuation of a civil-military knowledge gap in American society through undergraduate sociology. C1 US Mil Acad, West Point, NY 10996 USA. RP Ender, MG (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 35 TC 3 Z9 3 U1 0 U2 1 PU JOURNAL POLITICAL MILITARY SOCIOLOGY PI DE KALB PA DEPT SOCIOLOGY, NORTHERN ILLINOIS UNIV, DE KALB, IL 60115-2854 USA SN 0047-2697 J9 J POLIT MIL SOCIOL JI J. Polit. Mil. Soc. PD WIN PY 2005 VL 33 IS 2 BP 249 EP 266 PG 18 WC Political Science; Sociology SC Government & Law; Sociology GA 008MJ UT WOS:000235044600006 ER PT J AU Walsh, DS Thavichaigarn, P Pattanapanyasat, K Siritongtaworn, P Kongcharoen, P Tongtawe, P Yongvanitchit, K Jiarakul, N Dheeradhada, C Pearce, FJ Wiesmann, WP Webster, HK AF Walsh, DS Thavichaigarn, P Pattanapanyasat, K Siritongtaworn, P Kongcharoen, P Tongtawe, P Yongvanitchit, K Jiarakul, N Dheeradhada, C Pearce, FJ Wiesmann, WP Webster, HK TI Characterization of circulating monocytes expressing HLA-DR or CD71 and related soluble factors for 2 weeks after severe, non-thermal injury SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE polytrauma; immunology; monocyte; monokines; cytokines ID MULTIPLE ORGAN FAILURE; LYMPHOCYTE SUBSETS; INTERFERON-GAMMA; TRAUMA PATIENTS; MAJOR TRAUMA; WHOLE-BLOOD; MACROPHAGE DIFFERENTIATION; CYTOKINE PRODUCTION; URINARY NEOPTERIN; PERIPHERAL-BLOOD AB Background. Severe injury is associated with changes in monocytes that may contribute to poor outcomes. Longitudinal characterization of monocyte response patterns after trauma may provide added insight into these immunological alterations. Methods. Venous blood obtained seven times during post-injury days 1 through 13 from 61 patients with an injury severity score >20 was assessed by flow cytometry for monocytes (CD14+) expressing HIIA-DR or CD71 (transferrin receptor) and for circulating levels of interleukin (IL) 1 alpha, IL-1 beta, IL-6, soluble CD14 (sCD14), tumor necrosis factor-alpha (TNF-alpha), prostaglandin E-2 (PGE(2)), thromboxane B-2 (TXB2), and endotoxin. Urine neopterin was measured by high-pressure liquid chromatography, expressed as a neopterin-creatinine ratio. Results. Trauma patients had leucocytosis days 1 through 13, monocytosis days 5 through 13, reduced proportions of CD14+HIA-DR+ cells days 2 through 5, and elevated proportions of CD14+CD71+ cells days 1 through 13. Neopterin was elevated all days, peaking on day 10. sCD14 was elevated days 2 through 13, and there were sporadic elevations of IL-1 alpha, IL-10, IL-6, TNTF-alpha, PGE(2), TXB2, and endotoxin. Sepsis syndrome patients (n = 6) had larger and more prolonged reductions in CD14+HLA-DR+ cells and higher neopterin values, in comparison with uneventful patient outcomes. Conclusions. Altered proportions of monocytes expressing HILA-DR and CD71 and elevated sCD14 and urine neopterin levels, for up to 2 weeks after severe injury, underscores an extended period of profound immunological effects. Additional studies to more fully assess temporal monocyte response patterns after severe injury, including activation, may be warranted. (c) 2005 Elsevier Inc. All rights reserved. C1 AFRIMS, US Army Med Component, Dept Immunol & Med, Bangkok, Thailand. Phramongkutklao Royal Thai Army Hosp, Dept Surg, Bangkok, Thailand. Mahidol Univ, Siriraj Hosp, Off Res & Dev, Bangkok 10700, Thailand. Siriraj Hosp, Dept Surg, Bangkok, Thailand. Police Hosp, Dept Surg, Bangkok, Thailand. Walter Reed Army Inst Res, Div Mil Casualty Res, Washington, DC USA. RP Eisenhower Army Med Ctr, Serv Dermatol, Ft Gordon, GA 30905 USA. EM douglas.walsh@na.amedd.army.mil NR 72 TC 14 Z9 15 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 EI 1095-8673 J9 J SURG RES JI J. Surg. Res. PD DEC PY 2005 VL 129 IS 2 BP 221 EP 230 DI 10.1016/j.jss.2005.05.003 PG 10 WC Surgery SC Surgery GA 995WJ UT WOS:000234135000007 PM 16045935 ER PT J AU Barrett, A Cardello, A Maguire, P Peleg, M AF Barrett, A Cardello, A Maguire, P Peleg, M TI Moisture redistribution and textural changes in stored model sandwiches SO JOURNAL OF TEXTURE STUDIES LA English DT Article DE moisture migration; multilayer food; sandwiches; sensory-instrument correlation; texture; water activity ID SHELF-STABLE BREAD; STABILITY; STORAGE; STARCH AB Moisture migration and instrumental and sensory texture changes were determined in model cheese sandwich structures in which bread water activity was varied by glycerol level. Sandwiches and components were evaluated both after assembly and 4-week ambient storage by uniaxial compression and mathematical description of stress-strain relationships, assessment of sensory characteristics by a trained panel, correspondence between predicted and actual stress-strain relationships, and mass-balance analysis of moisture migration between cheese, bread crumb and bread crust. Textural changes occurred as a result of both aging and moisture migration, and the accuracy of fitted "predicted" stress-strain relationships of the composites varied according to the extent of moisture migration. Sensory assessments of key textural attributes of sandwich composites and components, before and after storage, were significantly correlated with measured mechanical parameters. C1 USA, Natwick Soldier Syst Ctr, Performance Enhancement & Food Safety Team, Combat Feeding Directorate, Natick, MA 01760 USA. USA, Natwick Soldier Syst Ctr, Prod Optimizat & Enhancement Team, Natick, MA 01760 USA. Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA. RP Barrett, A (reprint author), USA, Natwick Soldier Syst Ctr, Performance Enhancement & Food Safety Team, Combat Feeding Directorate, Natick, MA 01760 USA. EM ann.barrett@natick.army.mil NR 18 TC 3 Z9 3 U1 2 U2 9 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0022-4901 J9 J TEXTURE STUD JI J. Texture Stud. PD DEC PY 2005 VL 36 IS 5-6 BP 569 EP 588 DI 10.1111/j.1745-4603.2005.00032.x PG 20 WC Food Science & Technology SC Food Science & Technology GA 987LJ UT WOS:000233519100006 ER PT J AU Berkowitz, MJ Kim, DH AF Berkowitz, MJ Kim, DH TI Process and tubercle fractures of the hindfoot SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Article ID OS TRIGONUM SYNDROME; ENTIRE POSTERIOR PROCESS; TARSAL TUNNEL-SYNDROME; LATERAL PROCESS; SUBTALAR DISLOCATION; MEDIAL TUBERCLE; INTERNAL-FIXATION; TALUS; ANKLE; FOOT AB Process and tubercle fractures of the talus and calcaneus can be a source of significant pain and dysfunction. Successful management requires extensive knowledge of the complex osseoligamentous anatomy of the hindfoot. The large posterior process of the talus is composed of a medial and a lateral tubercle; an os trigonum may exist posterior to the lateral tubercle. The talus has a lateral process that articulates with the fibula and subtalar joint; the calcaneus possesses a frequently injured anterior process that articulates with the cuboid. Injury to these hindfoot structures is caused by inversion and eversion of the ankle, which can occur during athletic activity. These injuries often are misdiagnosed as ankle sprains. A high degree of clinical suspicion is warranted, and specialized radiographs or other imaging modalities may be required for accurate diagnosis. Nonsurgical management with cast immobilization is frequently successful when the fracture is correctly diagnosed acutely. Large fragments may be amenable to open reduction and internal fixation. Untreated, chronic injuries can cause significant pain and functional impairment that may be improved substantially with late surgical intervention. C1 Tripler Army Med Ctr, Orthopaed Surg Serv, Foot & Ankle Sect, Honolulu, HI 96859 USA. Univ Colorado, Sch Med, Denver, CO USA. Colorado Permanente Med Grp, Denver, CO USA. RP Berkowitz, MJ (reprint author), Tripler Army Med Ctr, Orthopaed Surg Serv, Foot & Ankle Sect, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 45 TC 18 Z9 21 U1 0 U2 4 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD DEC PY 2005 VL 13 IS 8 BP 492 EP 502 PG 11 WC Orthopedics SC Orthopedics GA 991CB UT WOS:000233788700002 PM 16330511 ER PT J AU Debboun, M Strickman, DA Klun, JA AF Debboun, M Strickman, DA Klun, JA TI Repellents and the military: Our first line of defense SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article; Proceedings Paper CT Symposium on Repellents held at the Annual Meeting of the American-Mosquito-Control-Association CY FEB 17-21, 2002 CL Denver, CO SP Amer Mosquito Control Assoc C1 USA, Med Dept Ctr & Sch, Med Zool Branch, Acad Hlth Sci, Ft Sam Houston, TX 78234 USA. USDA ARS, Natl Program Staff, Beltsville, MD 20705 USA. USDA ARS, Chem Affecting Insect Behav Lab, Beltsville, MD 20705 USA. RP Debboun, M (reprint author), USA, Med Dept Ctr & Sch, Med Zool Branch, Acad Hlth Sci, 3151 Scott Rd Ste 0408A, Ft Sam Houston, TX 78234 USA. NR 12 TC 14 Z9 14 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2005 VL 21 IS 4 SU S BP 4 EP 6 DI 10.2987/8756-971X(2005)21[4:RATMOF]2.0.CO;2 PG 3 WC Entomology SC Entomology GA 003JC UT WOS:000234676900002 PM 16921676 ER PT J AU Bhattacharjee, AK Gupta, RK AF Bhattacharjee, AK Gupta, RK TI Analysis of molecular stereoelectronic similarity between N,N-diethyl-m-toluamide (Deet) analogs and insect juvenile hormone to develop a model pharmacophore for insect repellent activity SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article; Proceedings Paper CT Symposium on Repellents held at the Annual Meeting of the American-Mosquito-Control-Association CY FEB 17-21, 2002 CL Denver, CO SP Amer Mosquito Control Assoc DE juvenile hormone; N,N-diethyl-m-toluarnide (DEET); juvenile hormone mimic; AM1 quantum; chemical sterecelectronic properties ID ELECTROSTATIC POTENTIALS; ELECTRONIC-PROPERTIES; TOBACCO HORNWORM; FIELD AB Similarity analysis on molecular stereoelectronic properties of N.N-diethyl-m-toluamide (DEET), natural insect juvenile hormone (JH), a synthetic insect juvenile hormone mimic (JH-mimic, undecen-2-yl carbamate), and DEET compounds reveals remarkable similarities that lead to a reliable phamacophore for the design of efficacious insect repellents and provide insights for understanding the mechanism of repellent action. The study involves an AMI quantum chemical computational procedure enabling a conformational search for the lowest and most abundant energy conformers of JH, JH-mimic, and 15 DEET compounds and complete geometry optimization of the conformers. Similarity analyses of stereoelectronic properties such as structural parameters, atomic charges, dipole moments, molecular electrostatic potentials, and highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energies were performed on JH. JH-mimic. and the DEET compounds. Similarity of stereoelectronic attributes of the amide/ester moiety, negative electrostatic potential regions beyond the molecular surface, and a large distribution of hydrophobic regions in the compounds appears to be the 3 important factors leading to a similar interaction with the JH receptor. The similarity of electrostatic profiles beyond the molecular surface is likely to play a crucial role toward molecular recognition interaction with the JH receptor from a distance which suggests a possible electrostatic bioisosterism of the amide group of the DEET compounds and JH-mimic and, thus, a model for molecular recognition at the JH receptor. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, Silver Spring, MD 20910 USA. USA, Med Res & Mat Command, Off Director Res Plans & Programs, Ft Detrick, MD 21702 USA. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Dept Med Chem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 25 TC 4 Z9 4 U1 0 U2 5 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2005 VL 21 IS 4 SU S BP 23 EP 29 DI 10.2987/8756-971X(2005)21[23:AOMSSB]2.0.CO;2 PG 7 WC Entomology SC Entomology GA 003JC UT WOS:000234676900006 PM 16921680 ER PT J AU Debboun, M Kuhr, DD Rueda, LM Pecor, JE AF Debboun, M Kuhr, DD Rueda, LM Pecor, JE TI First record of Culex (Culex) Coronator in Louisiana, USA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Culex coronator; Louisiana; mosquitoes; Culicidae; Diptera ID VIRUS; CULICIDAE; MOSQUITO; DIPTERA AB The 1st confirmed record of Culex coronator for Louisiana was made at Fort Polk, LA, from carbon dioxide-baited light trap and gravid trap collections performed from April to October 2004. In addition to the new record, 17 mosquito species in 5 genera (Aedes, Anopheles, Coquillettidia, Culex, and Psorophora) were collected. Collection-site and species distribution data are included. C1 USA, Ctr Hlth Promot & Prevent Med S, Ft McPherson, GA 30330 USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RP Debboun, M (reprint author), USA, Acad Hlth Sci, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. NR 16 TC 14 Z9 14 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2005 VL 21 IS 4 BP 455 EP 457 DI 10.2987/8756-971X(2006)21[455:FROCCC]2.0.CO;2 PG 3 WC Entomology SC Entomology GA 001WR UT WOS:000234573900018 PM 16506572 ER PT J AU Rueda, LM Iwakami, M O'Guinn, M Mogi, M Prendergast, BF Miyagi, I Toma, T Pecor, JE Wilkerson, RC AF Rueda, LM Iwakami, M O'Guinn, M Mogi, M Prendergast, BF Miyagi, I Toma, T Pecor, JE Wilkerson, RC TI Habitats and distribution of Anopheles sinensis and associated Anopheles Hyrcanus Group in Japan SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE mosquitoes; Anopheles sinensis; Hyrcanus Group; Aedes; Culex; Uranotaenia; Japan; Culicidae ID CULICIDAE; DIPTERA AB Mosquito collections were carried out in August 2002 and July 2003 in Japan. Anopheles sinensis of the Hyrcanus Group, Myzomyia Series of Anopheles, was the most common species encountered. The distribution and habitats of 5 Anopheles Hyrcanus Group species are included. Eight species belonging to Aedes, Culex, and Uranotaenia were found associated with An. sinensis in rice paddies and a variety of other larval habitats. C1 Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Dept Entomol, Silver Spring, MD 20910 USA. Ctr Human Hlth & Prevent Med Pacific, Entomol Program, APO, AP 96343 USA. Saga Univ, Fac Med, Dept Pathol & Biodef, Saga 8498501, Japan. RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Dept Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 22 TC 11 Z9 13 U1 0 U2 1 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2005 VL 21 IS 4 BP 458 EP 463 DI 10.2987/8756-971X(2006)21[458:HADOAS]2.0.CO;2 PG 6 WC Entomology SC Entomology GA 001WR UT WOS:000234573900019 PM 16506573 ER PT J AU Sames, WJ Schleich, SS Johnson, OD AF Sames, WJ Schleich, SS Johnson, OD TI Egg raft size and bionomical notes on Culiseta incidens theobald in western Washington SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Culiseta incidens; Culex pipiens; egg raft; bionomics; mosquito; Washington ID CULICIDAE; DIPTERA AB Beginning in January 2002 and ending in November 2003, data were collected on the size (eggs/egg raft) and occurrence of egg rafts laid by Culiseta incidens within 5 miles of Fort Lewis, WA. Culiseta incidens initiated oviposition in late March to early April and ceased oviposition in September-October. Twenty egg rafts from Culex pipiens, a larval habitat associate of Cs. incidens, were also collected during this study and that information is reported. Culex pipiens initiated oviposition in late May, and termination of oviposition appeared to occur in late August. The range of the number of eggs per raft was 59-329 for Cs. inicidens and 218-413 for Cx. pipiens. C1 USA, Ctr Hlth Promot & Prevent Med W, Ft Lewis, WA 98433 USA. RP Sames, WJ (reprint author), POB 594, Lexington, TX 78873 USA. NR 11 TC 1 Z9 1 U1 1 U2 3 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2005 VL 21 IS 4 BP 469 EP 471 DI 10.2987/8756-971X(2006)21[469:ERSABN]2.0.CO;2 PG 3 WC Entomology SC Entomology GA 001WR UT WOS:000234573900022 PM 16506576 ER PT J AU Behl, WK Read, J Pitt, A Wolfenstine, J Foster, D AF Behl, WK Read, J Pitt, A Wolfenstine, J Foster, D TI Temperature performance of the lithium/O-2 battery SO JOURNAL OF THE INDIAN CHEMICAL SOCIETY LA English DT Article AB The lithium-oxygen battery utilizing non-aqueous electrolyte demonstrates a high specific energy and limited rechargability(1,2). The main discharge products have been characterized and the effect of electrolyte properties on cell performance have been demonstrated. This paper describes the temperature performance of a lithium-oxygen battery using non-aqueous electrolyte and correlates this to changes in electrolyte viscosity with temperature. This paper presents the temperature performance of our baseline Li-O-2 cell in the temperature range from -30 degrees C to +40 degrees C at discharge rates from 0.5 to 0.05 mA/cm(2). C1 USA, Res Lab, AMSRD, ARL,SE,DC, DCelphi, MD 20783 USA. RP Behl, WK (reprint author), USA, Res Lab, AMSRD, ARL,SE,DC, 2800 Powder Mill Rd, DCelphi, MD 20783 USA. EM wbehl@arl.army.mil NR 5 TC 2 Z9 2 U1 1 U2 5 PU INDIAN CHEMICAL SOC PI CALCUTTA PA 92 ACHARYA PRAFULLA CHANDRA RD ATTN:DR INDRAJIT KAR/EXEC SEC, CALCUTTA 700009, INDIA SN 0019-4522 J9 J INDIAN CHEM SOC JI J. Indian Chem. Soc. PD DEC PY 2005 VL 82 IS 12 BP 1055 EP 1057 PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 001WK UT WOS:000234573200002 ER PT J AU Behl, WK Foster, D Read, J Wolfenstine, J AF Behl, WK Foster, D Read, J Wolfenstine, J TI Nanophase Sn composite anodes for Li-ion batteries SO JOURNAL OF THE INDIAN CHEMICAL SOCIETY LA English DT Article ID SIZE AB Two different nanophase Sn composites; one containing an inactive metal (Cu) matrix and the other an inactive ceramic (Li2O) matrix were investigated as replacement anodes for graphite in Li-ion batteries. The nanophase Sn-Cu composite was prepared by a chemical route whereas the nanophase Sn-Li2O composite was prepared by an in situ ball milling method. Electrochemical testing revealed an improvement in cycle life for both nanophase composites compared to similar composites with micron-scale particles. Reducing the micro-structural features (i.e. particle/grain/phase size) features from the micron-scale to the nanophase in composite anodes leads to an increase in the cycle lifetime. C1 USA, Res Lab, AMSRD, ARL,SE,DC, Adelphi, MD 20783 USA. RP Behl, WK (reprint author), USA, Res Lab, AMSRD, ARL,SE,DC, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM wbehl@arl.army.mil NR 6 TC 0 Z9 0 U1 0 U2 1 PU INDIAN CHEMICAL SOC PI CALCUTTA PA 92 ACHARYA PRAFULLA CHANDRA RD ATTN:DR INDRAJIT KAR/EXEC SEC, CALCUTTA 700009, INDIA SN 0019-4522 J9 J INDIAN CHEM SOC JI J. Indian Chem. Soc. PD DEC PY 2005 VL 82 IS 12 BP 1119 EP 1121 PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 001WK UT WOS:000234573200011 ER PT J AU Brooks, JP Albert, PS Wilder, RB Gant, DA McLeod, DG Poggi, MM AF Brooks, JP Albert, PS Wilder, RB Gant, DA McLeod, DG Poggi, MM TI Long-term salvage radiotherapy outcome after radical prostatectomy and relapse predictors SO JOURNAL OF UROLOGY LA English DT Article DE prostate; prostatic neoplasms; radiation; prostatectomy; salvage therapy ID LYMPHOVASCULAR INVASION; CLINICAL FAILURES; RADIATION-THERAPY; CANCER; ANTIGEN; PSA; DISEASE; PROGRESSION; ELEVATION; ADJUVANT AB Purpose: We assessed the efficacy of salvage radiotherapy (SRT) and analyzed predictors of biochemical progression-free survival (bPFS) and distant metastasis-free survival in patients with clinically localized disease recurrence after radical prostatectomy. Materials and Methods: The records of 114 patients treated with SRT at 2 institutions between 1991 and 2001 were retrospectively reviewed. Time to biochemical recurrence and to distant metastases was analyzed using the Kaplan-Meier estimation. Candidate predictors of bPFS and distant metastasis-free survival were analyzed using the log rank test and Cox regression. Acute and late complications were scored using Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria. Results: At a median followup of 6.3 years (range 1.9 to 13.3) for SRT 4 and 6-year bPFS was 50% (95% CI 42% to 61%) and 33% (95% CI 24% to 43%), respectively. The 6-year actuarial probability of distant metastases after SRT was 14%. Multivariate analysis demonstrated an independent association of increasing Gleason score, lymphovascular invasion and lack of a complete response to SRT with decreased 5-year bDFS. These factors were associated with significantly less 5-year distant metastasis-free survival. Pre-RT prostate specific antigen greater than 2.0 ng/ml was associated with significantly decreased 5-year bDFS and distant metastasis-free survival, although it was not maintained on multivariate analysis. Conclusions: SRT results in durable prostate specific antigen control in select patients. It is well tolerated with few severe late effects. Increasing Gleason score, lymphovascular invasion and lack of a complete response to SRT are significant risks for disease progression requiring additional management. C1 USN, Div Radiat Oncol, Natl Med Ctr, Bethesda, MD 20889 USA. Walter Reed Army Med Ctr, Dept Urol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Sect Radiat Oncol, Washington, DC 20307 USA. NCI, Biometr Res Branch, Bethesda, MD 20892 USA. RP Poggi, MM (reprint author), USN, Div Radiat Oncol, Natl Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM mmpoggi@bethesda.med.navy.mil NR 20 TC 23 Z9 24 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD DEC PY 2005 VL 174 IS 6 BP 2204 EP 2208 DI 10.1097/01.ju.0000181223.99576.ff PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 984HN UT WOS:000233293700033 PM 16280764 ER PT J AU Kengluecha, A Rongnoparut, P Boonsuepsakul, S Sithiprasasna, R Rodpradit, P Baimai, V AF Kengluecha, Ampornpan Rongnoparut, Pornpimol Boonsuepsakul, Soamrutai Sithiprasasna, Ratana Rodpradit, Prinyada Baimai, Visut TI Geographical distribution of Anopheles minimus species A and C in western Thailand SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Anopheles minimus; species distribution; molecular identification; malaria; Thailand ID IDENTIFICATION; COMPLEX; CULICIDAE; VIETNAM; DIPTERA AB Elucidating vector distribution based on an accurate species identification is important to understanding the nature of the species complex in order to achieve vector control. Morphologically, An. minimus s.l. is difficult to distinguish from both its species complex and its closely related species. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique and a single multiplex-allele specific PCR developed for species identification were applied in this study in comparison with morphological identification. Both methods were used, combining with geographical information systems to determine the distribution of An. minimus species A and C. The investigation on the breeding habitats was performed in the malarious area of western Thailand. Anopheles larvae were collected from 36 bodies of water among five districts (Sangkhaburi, Thong Pha Phum, Si Sawat, Muang, and Sai Yok) of Kanchanaburi Province, Thailand. In this study, An. minimus A larvae were present in all study districts but the association differed when focusing on study sites within each district. Although there were many reports of An. minimus A in Ban Phu Rat and Ban Phu Toei villages in Sai Yok District, we did not find the breeding sites of species A in those two areas. An. minimus A and C were found in Ban Phu Ong Ka village in Sai Yok District. The breeding habitats of An. minimus C were present covering 30-40 km of distance in northern part of Sai Yok and this species was also found in the central and southern parts of Si Sawat District. C1 Mahidol Univ, Fac Sci, Dept Biol, Bangkok 10400, Thailand. Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Mahidol Univ, Fac Sci, Ctr Vectors & Vector Borne Dis, Bangkok 10400, Thailand. RP Baimai, V (reprint author), Mahidol Univ, Fac Sci, Dept Biol, Bangkok 10400, Thailand. NR 15 TC 14 Z9 14 U1 1 U2 1 PU SOC VECTOR ECOLOGY PI SANTA ANA PA PO BOX 87, SANTA ANA, CA 92702 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2005 VL 30 IS 2 BP 225 EP 230 PG 6 WC Entomology SC Entomology GA 082NH UT WOS:000240393100009 PM 16599156 ER PT J AU Zhang, CL Mammen, MP Chinnawirotpisan, P Klungthong, C Rodpradit, P Monkongdee, P Nimmannitya, S Kalayanarooj, S Holmes, EC AF Zhang, CL Mammen, MP Chinnawirotpisan, P Klungthong, C Rodpradit, P Monkongdee, P Nimmannitya, S Kalayanarooj, S Holmes, EC TI Clade replacements in dengue virus serotypes 1 and 3 are associated with changing serotype prevalence SO JOURNAL OF VIROLOGY LA English DT Article ID HEMORRHAGIC-FEVER; MOLECULAR EPIDEMIOLOGY; EVOLUTION; THAILAND; INFECTION; SELECTION; BANGKOK; POPULATION; EMERGENCE; RESPONSES AB The evolution of dengue virus (DENY) is characterized by phylogenetic trees that have a strong temporal structure punctuated by dramatic changes in clade frequency. To determine the cause of these large-scale phylogenetic patterns, we examined the evolutionary history of DENY serotype 1 (DENY-1) and DENV-3 in Thailand, where gene sequence and epidemiological data are relatively abundant over a 30-year period. We found evidence for the turnover of viral clades in both serotypes, most notably in DENV-1, where a major clade replacement event took place in genotype I during the mid-1990s. Further, when this clade replacement event was placed in the context of changes in serotype prevalence in Thailand, a striking pattern emerged; an increase in DENV-1 clade diversity was associated with an increase in the abundance of this serotype and a concomitant decrease in DENV-4 prevalence, while clade replacement was associated with a decline in DENV-1 prevalence and a rise of DENV-4. We postulate that intraserotypic genetic diversification proceeds at times of relative serotype abundance and that replacement events can result from differential susceptibility to cross-reactive immune responses. C1 Penn State Univ, Mueller Lab, Ctr Infect Dis Dynam, Dept Biol, University Pk, PA 16802 USA. Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. Armed Forces Res Inst Med Sci, USA Med Component, Dept Virol, Bangkok 10400, Thailand. RP Holmes, EC (reprint author), Penn State Univ, Mueller Lab, Ctr Infect Dis Dynam, Dept Biol, University Pk, PA 16802 USA. EM ech15@psu.edu OI Holmes, Edward/0000-0001-9596-3552 NR 46 TC 119 Z9 123 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 2005 VL 79 IS 24 BP 15123 EP 15130 DI 10.1128/JVI.79.24.15123-15130.2005 PG 8 WC Virology SC Virology GA 997VK UT WOS:000234276700014 PM 16306584 ER PT J AU Baldrate, BC AF Baldrate, BC TI The supreme court's role in defining the jurisdiction of military tribunals: A study, critique, & proposal for Hamdan v. Rumsfeld SO MILITARY LAW REVIEW LA English DT Review ID MARTIAL JURISDICTION; UNITED-STATES; COMMAND RESPONSIBILITY; WAR POWERS; CONSTITUTION; FIDELITY; LAW; PRINCIPLES; RIGHTS; TRANSLATION C1 USA, Litigat Div, Arlington, VA 22209 USA. RP Baldrate, BC (reprint author), USA, Litigat Div, Arlington, VA 22209 USA. NR 174 TC 2 Z9 2 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2005 VL 186 BP 1 EP 115 PG 115 WC Law SC Government & Law GA 019SM UT WOS:000235857000001 ER PT J AU Evans, R Reynolds, K Creedon, J Murphy, M AF Evans, R Reynolds, K Creedon, J Murphy, M TI Incidence of acute injury related to fitness testing of US army personnel SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 50th Annual Meeting of the American-College-of-Sports-Medicine CY MAY 28-31, 2003 CL San Francisco, CA SP Amer Coll Sports Med ID LOW-BACK-PAIN; PHYSICAL-FITNESS; ABDOMINAL EXERCISES; INFANTRY SOLDIERS; RISK-FACTORS; SIT-UP; MUSCLE; ENDURANCE; STRENGTH; VARIETY AB Objective: This study documented the incidence of acute injuries related to the Army Physical Fitness Test (APFT). Methods: A questionnaire was administered to 1,532 soldiers after they completed a biannual APFT. Self-reported injury responses determined the rates of injuries resulting from the push-up, sit-up, and 2-mile run events and were classified into three categories, i.e., all injuries, performance-limiting injuries, and time-loss injuries. Results: A total of 117 soldiers (injury rate, 7.6%) reported sustaining an injury (all injuries), with 11% attributed to the push-up event, 56% to the sit-up event, and 32% to the run event. Forty-six of these injuries reportedly limited performance (injury rate, 3.0%), and 11 soldiers received a duty-limiting profile (time-loss injury rate, 0.7%), which did not differ among events. Injury rates were not significantly associated with the number of sit-ups performed per week or the number of days per week a soldier participated in physical training and were not greater for soldiers who trained specifically for the APFT. History of previous injury was a significant risk factor for injury. Conclusion: The push-up, sit-up, and run events of the APFT do not pose a considerable acute injury risk to active duty soldiers. C1 USA, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. RP Evans, R (reprint author), USA, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. NR 34 TC 9 Z9 9 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2005 VL 170 IS 12 BP 1005 EP 1011 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 019JU UT WOS:000235832200005 PM 16491936 ER PT J AU Waibel, KH AF Waibel, KH TI Allergic rhinitis in the Middle East SO MILITARY MEDICINE LA English DT Article ID ATOPIC ECZEMA; ASTHMA; POLLEN; DESERT; KUWAIT; AEROALLERGENS; PREVALENCE; SYMPTOMS AB Background: Current military operations in the Middle East involve active duty, National Guard, and reserve troops from all services. Despite common misconceptions, the desert environment in this region has significant aeroallergen seasons that may exacerbate allergic rhinitis. Objective: To review perennial and seasonal aeroallergen trends in the Middle East. Results: Most countries have significant grass and weed pollen seasons during April to May and September to October, respectively. Indigenous trees such as date palm, acacia, and mesquite have specific pollen seasons from March to May. Mold allergens are perennial with seasonal peaks, whereas house dust mite is common in humid coastal regions. Conclusions: Seasonal and perennial allergens observed in the United States are also found in the Middle East. Furthermore, the prevalence of allergic rhinitis in these countries suggests that local aeroallergens exacerbate symptoms. Health care providers should counsel deploying soldiers with allergic rhinitis regarding relevant allergen trends, ensuring that these individuals have appropriate medications. C1 Dwight D Eisenhower Army Med Ctr, Allergy Immunol Serv, Dept Med, Ft Gordon, GA 30905 USA. RP Waibel, KH (reprint author), Dwight D Eisenhower Army Med Ctr, Allergy Immunol Serv, Dept Med, Ft Gordon, GA 30905 USA. NR 23 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2005 VL 170 IS 12 BP 1026 EP 1028 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 019JU UT WOS:000235832200009 PM 16491940 ER PT J AU McClung, JP Scrimgeour, AG AF McClung, JP Scrimgeour, AG TI Zinc: An essential trace element with potential benefits to soldier SO MILITARY MEDICINE LA English DT Article ID ACUTE CUTANEOUS LEISHMANIASIS; STATES MILITARY PERSONNEL; CONTROLLED-TRIAL; DIARRHEAL-DISEASE; DOUBLE-BLIND; PLASMODIUM-FALCIPARUM; INFECTIOUS-DISEASES; YOUNG-CHILDREN; DESERT-SHIELD; SUPPLEMENTATION AB Zinc is a trace element known to be an essential nutrient for life. It functions as a cofactor for numerous enzymes, including those involved in DNA and RNA replication and protein synthesis. Soldiers represent a unique population faced with intense metabolic and mental demands, as well as exposure to various immune challenges. Some of these factors may affect their dietary zinc requirements. Although severe zinc deficiency is unlikely to occur, some soldiers may experience less than optimal zinc status because of diminished intake coupled with increased requirements. For those soldiers, supplemental dietary zinc may serve a protective function in numerous disease states affecting modem warfighters. This review highlights the importance of adequate zinc nutriture to soldiers and discusses the potential benefits of supplemental zinc in a number of diseases currently affecting soldiers, including diarrhea, respiratory diseases, malaria, and leishmaniasis. C1 USA, Res Inst Environ Med, Mil Nutr Div, Natick, MA 01760 USA. RP McClung, JP (reprint author), USA, Res Inst Environ Med, Mil Nutr Div, Natick, MA 01760 USA. RI McClung, James/A-1989-2009; Scrimgeour, Angus/D-6794-2013 NR 65 TC 6 Z9 7 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2005 VL 170 IS 12 BP 1048 EP 1052 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 019JU UT WOS:000235832200015 PM 16491946 ER PT J AU McAvin, JC Escamilla, EM Blow, JA Turell, MJ Quintana, M Bowles, DE Swaby, JA Barnes, WJ Huff, WB Lohman, KL Atchley, DH Hickman, JR Niemeyer, DM AF McAvin, JC Escamilla, EM Blow, JA Turell, MJ Quintana, M Bowles, DE Swaby, JA Barnes, WJ Huff, WB Lohman, KL Atchley, DH Hickman, JR Niemeyer, DM TI Rapid identification of dengue virus by reverse transcription-polymerase chain reaction using field-deployable instrumentation SO MILITARY MEDICINE LA English DT Article ID MALE AEDES-AEGYPTI; HEMORRHAGIC-FEVER; PCR; ALIGNMENT; SYSTEM; RNA; AMPLIFICATION; CULICIDAE; INFECTION; DIAGNOSIS AB Dengue virus universal and dengue serotype 1 to 4, fluorogenic probe hydrolysis (TaqMan), reverse transcription-polymerase chain reaction assays were developed for screening and serotype identification of infected mosquito vectors and human sera using a field-deployable, fluorometric thermocycler. Dengue universal and dengue 1 to 4 serotype assay in vitro sensitivity and specificity results were 100% concordant when tested with total nucleic acid extracts of multiple strains of dengue serotype 1 to 4, yellow fever, Japanese encephalitis, West Nile, and St. Louis encephalitis viruses. The in vitro sensitivity and specificity results for all five assays were concordant when tested with a blind panel of 27 dengue virus-infected mosquitoes, 21 non-dengue (yellow fever, West Nile, or St. Louis encephalitis) flavivirus-infected mosquitoes, and 11 uninfected mosquitoes and with clinical specimens consisting of a human serum panel of eight dengue viremic and 31 non-dengue-infected febrile patient serum samples. No cross-reaction occurred with vector species or human genomic DNA. Sample processing and polymerase chain reaction required < 2 hours. C1 USAF, Inst Environm Safety & Occupat Hlth Anal, Epidemiol Surveillance Div, San Antonio, TX 78235 USA. USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. USA, Ctr Hlth Promot & Prevent Med W, Div Environm Sci, Ft Lewis, WA 98433 USA. USAF, Force Battlelab, Lackland Air Force Base, San Antonio, TX 78236 USA. USAF, Off Surg Gen, Bolling Air Force Base, Washington, DC 20332 USA. Joint Program Execut Off Chem & Biol Def, Falls Church, VA 22041 USA. RP McAvin, JC (reprint author), USAF, Inst Environm Safety & Occupat Hlth Anal, Epidemiol Surveillance Div, San Antonio, TX 78235 USA. NR 31 TC 9 Z9 9 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2005 VL 170 IS 12 BP 1053 EP 1059 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 019JU UT WOS:000235832200016 PM 16491947 ER PT J AU McAvin, JC Bowles, DE Swaby, JA Blount, KW Blow, JA Quintana, M Hickman, JR Atchley, DH Niemeyer, DM AF McAvin, JC Bowles, DE Swaby, JA Blount, KW Blow, JA Quintana, M Hickman, JR Atchley, DH Niemeyer, DM TI Identification of Aedes aegypti and its respective life stages by real-time polymerase chain reaction SO MILITARY MEDICINE LA English DT Article ID FORCE OVITRAPPING PROGRAM; UNITED-STATES; DISTRIBUTIONAL RECORDS; ALBOPICTUS; DENGUE; TRISERIATUS; EXTRACTION; CULICIDAE; DIPTERA; PCR AB An Aedes aegypti-specific, fluorogenic probe hydrolysis (Taq-Man), polymerase chain reaction assay was developed for real-time screening using a field-deployable thermocycler. Laboratory-based testing of A. aegypti, A. aegypti (Trinidad strain), Culex pipiens, Culex quinquefasciatus, Anopheles stephensi, and Ochlerotatus taeniorhynchus individual adult mosquitoes and mixed pools (n = 10) demonstrated 100% concordance in both in vitro sensitivity (six of six samples) and specificity (10 of 10 samples). A single adult A. aegypti was identified in a pool of 100 non-A. aegypti mosquitoes. The limit of detection of A. aegypti egg pools was five individual eggs. Field testing was conducted in central Honduras, An A. aegypti and Culex spp. panel of individual and mixed pools (n = 30) of adult mosquitoes, pupae, and larvae demonstrated 100% concordance in sensitivity (22 of 22 samples) and 97% concordance in specificity (29 of 30 samples), with one false-positive result. Field testing of an A. aegypti and Culex spp. blind panel (n = 16) consisting of individual and mixed pools of adult mosquitoes, pupae, and larvae demonstrated 90% concordance in sensitivity (nine of 10 samples) and 88% concordance in specificity (14 of 16 samples). C1 USAF, Inst Environm Safety & Occupat Hlth Anal, Epidemiol Surveillance Div, San Antonio, TX 78235 USA. USAF, Force Protect Battlelab, Lackland Air Force Base, San Antonio, TX 78236 USA. USAF, Sch Aerosp Med, Brooks Air Force Base, San Antonio, TX 78235 USA. USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. USA, Ctr Hlth Promot & Prevent Med W, Div Environm Sci, Ft Lewis, WA 98433 USA. USAF, Off Surg Gen, Baolling Air Force Base, Washington, DC 20332 USA. Joint Program ExecutChem Biol Def, Falls Church, VA 22041 USA. RP McAvin, JC (reprint author), USAF, Inst Environm Safety & Occupat Hlth Anal, Epidemiol Surveillance Div, San Antonio, TX 78235 USA. NR 24 TC 6 Z9 6 U1 1 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2005 VL 170 IS 12 BP 1060 EP 1065 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 019JU UT WOS:000235832200017 PM 16491948 ER PT J AU Landau, ME Barner, KC Murray, ED Campbell, WW AF Landau, ME Barner, KC Murray, ED Campbell, WW TI Cold elbow syndrome: Spurious slowing of ulnar nerve conduction velocity SO MUSCLE & NERVE LA English DT Article; Proceedings Paper CT 55th Annual Meeting of the American-Academy-of-Neurology CY MAR 29-APR 05, 2003 CL HONOLULU, HI SP Amer Acad Neurol DE elbow; electrodiagnosis; nerve conduction velocity; temperature; ulnar neuropathy ID TEMPERATURE; NEUROPATHY AB Low temperature decreases nerve conduction velocity (NCV). The across-elbow segment of the ulnar nerve is superficial and may be particularly susceptible to decreased temperature. We evaluated patients without clinical ulnar neuropathy at the elbow (UNE) but with isolated slowing of the across-elbow ulnar NCV (normal group), and patients with clinical and electrodiagnostic findings of UNE (UNE group). All subjects had ulnar motor nerve studies completed before and after warming. The mean across-elbow NCV was 43.4 m/s and 48.6 m/s (P < 0.0001) in the normal group, and 37.4 m/s and 37.7 m/s (P = 0.90) in the LINE group, before and after warming, respectively. There was no change in the forearm segment NCV in either group. Seventeen of 32 subjects in the normal group had completely normal studies after warming. No patients with LINE developed normal across-elbow NCV with warming. Low temperature slows across-elbow ulnar NCV in normal subjects without impact on the forearm segment. Warming of the elbow improves across-elbow ulnar NCV in normals, but does not reverse the abnormalities in patients with UNE. Elbow warming should become a routine part of ulnar nerve conduction studies, especially when there is isolated conduction slowing in the across-elbow segment. C1 Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Landau, ME (reprint author), Walter Reed Army Med Ctr, Dept Neurol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Mark.Landau@NA.AMEDD.ARMY.MIL NR 7 TC 9 Z9 9 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD DEC PY 2005 VL 32 IS 6 BP 815 EP 817 DI 10.1002/mus.20420 PG 3 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 990HP UT WOS:000233734100016 PM 16116653 ER PT J AU Davis, VT Thompson, J Covington, A AF Davis, VT Thompson, J Covington, A TI Laser photodetachment electron spectroscopy studies of heavy atomic anions SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 18th International Conference on Application of Accelerators in Research and Industry (CAARI) CY OCT 10-15, 2004 CL Ft Worth, TX SP US DOE, Natl Sci Fdn, Int Atom Energy Agcy, Natl Canc Inst, Sadia Natl Lab, Oak Ridge Natl Lab, Oak Ridge Associated Univ, Los Alamos Natl Lab, Synergy Vaccum, Ft Worth Convent & Vistors Bureau, Elsevier B V, Univ N Texas DE electron affinity; negative ions; lanthanides; hafnium ID NEGATIVE-IONS; AFFINITIES; YB; LANTHANIDES; ENERGIES; LUTETIUM; BINDING; STATES AB Laser photodetachment electron spectroscopy (LPES) experiments have been performed at the Negative Ion Research Facility at the University of Nevada, Reno, using a crossed ion-laser beams apparatus to investigate the structure and dynamics of heavy atomic anions. A small ion accelerator is used to produce monoenergetic beams of negatively-charged atomic ions. Ejected electrons (photoelectrons), produced by the collision of the ions with linearly-polarized photons, are collected and their kinetic energy is measured with a hemispherical-sector electrostatic analyzer. The resultant photoelectron spectrum is used to determine the electron affinity (EA) of several of the lanthanides, while limits on the electron affinities for others are inferred. In addition, the angular asymmetry parameters and angular distribution patterns of photoelectrons created by laser photodetachment of several heavy atomic anions, as well as the spectral dependence of those angular distributions, have been determined. Electron affinities and photoelectron angular distribution asymmetry parameters can offer crucial information regarding the electronic structures of these heavy atomic anions, and represent key information for models of these complex systems. (c) 2005 Elsevier B.V. All rights reserved. C1 US Mil Acad, West Point, NY 10996 USA. Univ Nevada, Reno, NV 89557 USA. RP Davis, VT (reprint author), US Mil Acad, POB 93, West Point, NY 10996 USA. EM vernon.davis@us.army.mil OI Thompson, Jeffrey/0000-0001-9699-5767 NR 42 TC 14 Z9 14 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD DEC PY 2005 VL 241 IS 1-4 BP 118 EP 124 DI 10.1016/j.nimb.2005.07.073 PG 7 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA 997PX UT WOS:000234260000029 ER PT J AU Allen, KS Naessens, EP AF Allen, KS Naessens, EP TI Monte Carlo-based analysis for the transmutation of transuranic waste recycled in light water reactors SO NUCLEAR TECHNOLOGY LA English DT Article DE transuranic waste; MONTEBURNS; transmutation ID FUEL-CYCLE AB Analysis is performed on the production and destruction rates of recycled transuranics (TRUs) in a light water reactor (LWR)fuel assembly using a Monte Carlo-based fuel depletion code (MONTEBURNS 2. 0). Thirteen TRUs were recycled into the LWR model through ten 3-yr burnup cycles for a total depletion period of 30 yr. The focus of the research was to determine the relative reduction of TRU waste within the fuel cycle and determine the impact of the recycled TRUs on fuel criticality, waste toxicity, activity, and heat-load production. The amount of TRUs could be reduced by more than a factor of 4 for a 30-yr period when these 13 isotopes were recycled. C1 US Mil Acad, Dept Phys, Nucl Engn Res Grp, West Point, NY 10996 USA. RP Allen, KS (reprint author), US Mil Acad, Dept Phys, Nucl Engn Res Grp, Bartlett Hall, West Point, NY 10996 USA. EM Kenneth.Allen@usma.edu NR 15 TC 2 Z9 2 U1 0 U2 1 PU AMER NUCLEAR SOCIETY PI LA GRANGE PK PA 555 N KENSINGTON AVENUE, LA GRANGE PK, IL 60526 USA SN 0029-5450 J9 NUCL TECHNOL JI Nucl. Technol. PD DEC PY 2005 VL 152 IS 3 BP 354 EP 366 PG 13 WC Nuclear Science & Technology SC Nuclear Science & Technology GA 985LH UT WOS:000233378500009 ER PT J AU Chen, W Panchang, V Demirbilek, Z AF Chen, W Panchang, V Demirbilek, Z TI On the modeling of wave-current interaction using the elliptic mild-slope wave equation SO OCEAN ENGINEERING LA English DT Article DE mild-slope equation; elliptic wave model; wave-current interaction ID SLOWLY VARYING TOPOGRAPHY; COASTAL REGIONS; WATER-WAVES; BOUSSINESQ EQUATIONS; MULTIGRID TECHNIQUE; PROPAGATION MODELS; HARBOR; VERIFICATION; SIMULATION; DISPERSION AB Methods to incorporate the effect of ambient currents in the prediction of nearshore wave transformation are developed. This is accomplished through the construction of a finite-element coastal/harbor wave model based on an extended mild-slope wave-current equation that includes wave breaking. Improved boundary conditions are used to provide more accurate forcing and to minimize spurious wave reflections from the boundaries. Multiple nonlinear mechanisms, appearing both in the governing equations and in the boundary conditions, are handled successfully and efficiently with iterative techniques. The methods are tested against results from other types of models based on parabolic approximations or Boussinesq equations for three wave-current problems of common interest and varying complexity. While indicating good agreement in general, the analysis also highlights the limitations of parabolic approximation models in case of strong local currents and velocity shear. We also consider the harbor engineering problem pertaining to waves approaching an inlet with a jettied entrance, wherewave-current interaction can create a complex wave pattern that adversely affects small craft navigation and causes scouring. The role of ebb and flood currents on wave transformation and on breaking in the vicinity of the inlet is investigated using the model in conjunction with hydraulic laboratory data. It is found that although the ebb currents cause larger waves outside the inlet, much of the wave energy is soon dissipated due to breaking; during the flood tide, in contrast, more wave energy can penetrate into the inlet throat. (c) 2005 Elsevier Ltd. All rights reserved. C1 Texas A&M Univ, Dept Maritime Syst Engn, Galveston, TX 77553 USA. Pacific Int Engn, PLLC, Edmonds, WA 98020 USA. Army Engn R&D Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA. RP Chen, W (reprint author), Texas A&M Univ, Dept Maritime Syst Engn, Galveston, TX 77553 USA. EM weic@piengr.com; panchanv@tamug.tamu.edu; demirbilek@erdc.usare.army.mil NR 50 TC 27 Z9 31 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD DEC PY 2005 VL 32 IS 17-18 BP 2135 EP 2164 DI 10.1016/j.oceaneng.2005.02.010 PG 30 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 979UH UT WOS:000232969900009 ER PT J AU Sadjadi, FA Chun, CSL Sullivan, A Gaunaurd, GC AF Sadjadi, FA Chun, CSL Sullivan, A Gaunaurd, GC TI Buried object characterization via ground-penetrating radar and Huynen polarimetric parameters SO OPTICAL ENGINEERING LA English DT Article DE polarimetric radar; ground-penetrating radar; electromagnetic scattering; Mueller matrix; Huynen parameters; method of moments ID MUELLER MATRIX; DECOMPOSITION AB A known target buried underground and illuminated from the air on its top flat surface by a ground-penetrating radar (GPR) is used to verify the results of a polarization approach that uses the Huynen parameters. The target is a dielectric cylinder of diameter d and height h that simulates a land mine buried in soil, flat top surface looking up. A method-of-moments (MoM) approach (and codes) is used to generate the complex elements of the scattering matrix S of the present target. These elements are obtained in modulus and phase as functions of frequency in the wide band; 0 <= f <= 5 GHz, for various angles of incidence of the radar beam on the air-ground interface. That matrix S is then used to generate the elements of the traditional Mueller matrix M ' by several methods, which are described. The Huynen parameters are then extracted from M ' and the pertinent nonvanishing ones are plotted versus frequency in the same band. This extraction is done with care because Huynen defined his M ' differently than in the traditional fashion-a great source of confusion. After several appropriate changes the results agree with those of earlier works. As confirmation, the values of the Huynen parameters revert and recover the original elements of M ' they are extracted from. The plots of the Huynen parameters for this target indeed give a general phenomenological description of the buried, symmetric object with differences in local curvatures and somewhat irregular structure that was originally conceived. The displayed plots of various nonvanishing elements of M ' and of the Huynen parameters, at normal and oblique incidences verify our conclusions and the method. (c) 2005 Society of Photo-Optical Instrumentation Engineers. C1 USA, Res Lab, Adelphi, MD 20783 USA. Lockheed Martin Corp, Eagan, MN 55121 USA. Phys Innovat Inc, Inver Grove Hts, MN 55076 USA. RP Sadjadi, FA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM GGaunaurd@arl.army.mil NR 16 TC 4 Z9 4 U1 0 U2 2 PU SPIE-INT SOCIETY OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD DEC PY 2005 VL 44 IS 12 AR 126201 DI 10.1117/1.2148940 PG 15 WC Optics SC Optics GA 006LE UT WOS:000234898200029 ER PT J AU Barry, JD AF Barry, JD TI Diagnosis and management of the poisoned child SO PEDIATRIC ANNALS LA English DT Article ID EXPOSURE SURVEILLANCE SYSTEM; IPECAC-INDUCED EMESIS; CONTROL-CENTERS; GASTRIC LAVAGE; AMERICAN-ASSOCIATION; ACTIVATED-CHARCOAL; PEDIATRIC INGESTIONS; SIMULATED OVERDOSE; EFFICACY; HOME C1 Brooke Army Med Ctr, Dept Emergency Med, Med Toxicol Consulat Serv, Ft Sam Houston, TX 78234 USA. San Antonio Uniformed Serv Hlth Educ Consortium E, San Antonio, TX USA. RP Barry, JD (reprint author), Brooke Army Med Ctr, Dept Emergency Med, Med Toxicol Consulat Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jdave.barry@us.army.mil NR 47 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0090-4481 J9 PEDIATR ANN JI Pediatr. Annu. PD DEC PY 2005 VL 34 IS 12 BP 936 EP 946 PG 11 WC Pediatrics SC Pediatrics GA 992SE UT WOS:000233903400005 ER PT J AU Munavalli, S Rohrbaugh, DK Mackay, RA Longo, FR Durst, HD AF Munavalli, S Rohrbaugh, DK Mackay, RA Longo, FR Durst, HD TI Reaction of epoxides with (alkylthio)methyl chloride SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE epoxide ring cleavage; formation of novel compounds; free radical reactions; (methylthio)methylchloride 1,2-epoxybutane styrene oxide ID TRIMETHYLSILYL CYANIDE; CONVERSION; HALOHYDRINS; EFFICIENT; STYRENE; REGIO; OXIDE AB The reaction of (methylthio)methylchloride with 1,2-epoxybutane and styrene oxide furnishes eleven and eight compounds, respectively. The probable mechanism of their formation and their mass spectral characterization are presented in this article. C1 Geocenters Inc, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Munavalli, S (reprint author), Geocenters Inc, Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM shekar.munavalli@us.army.mil NR 40 TC 1 Z9 1 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PD DEC PY 2005 VL 180 IS 12 BP 2689 EP 2700 DI 10.1080/104265090930425 PG 12 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 996YT UT WOS:000234212900008 ER PT J AU Wang, GX Gertner, GZ Fang, SF Anderson, AB AF Wang, GX Gertner, GZ Fang, SF Anderson, AB TI A methodology for spatial uncertainty analysis of remote sensing and GIS products SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article ID SOIL LOSS EQUATION; GEOSTATISTICAL METHODS; TOPOGRAPHICAL FACTOR; MULTIPLE-VARIABLES; CATEGORICAL MAPS; SENSED DATA; MODEL; ERROR; RESOLUTIONS; SENSITIVITY AB When remote sensing and GIS products ore generated, errors and uncertainties from collection, processing and analysis of image and ground data, and model development, accumulate and are propagated to the maps. The products thus possess many sources of uncertainties that vary spatially and temporally. Spatially identifying the sources of uncertainties, modeling their accumulation and propagation, and finally, quantifying them will be critical to control the quality of spatial data. This paper demonstrates a methodology and its applications for a case study in which uncertainty of predicted soil erosion is hierarchically partitioned into various primary components on a pixel-by-pixel basis. The methodology is based on a regionalized variable theory of variables. It integrates remote sensing aided co-simulation algorithms in geo-statistics, and uncertainty and error budget methods in uncertainty analysis. The simulation algorithms generate realizations that can be used to calculate local estimates, and the variances and co-variances between them. Uncertainty and error budget methods partition the uncertainty of output into various input components and quantify their relative uncertainty contributions. The results can thus suggest the main uncertainty sources and their variation spatially, and further provide a rationale to reduce errors in map generation and application. C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. USA, Corps Engineers, CERL, Champaign, IL 61826 USA. RP Univ Illinois, Dept Nat Resources & Environm Sci, W-503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@uiuc.edu NR 52 TC 14 Z9 16 U1 2 U2 12 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD DEC PY 2005 VL 71 IS 12 BP 1423 EP 1432 PG 10 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA 994TU UT WOS:000234054900009 ER PT J AU Mattiucci, N D'Aguanno, G Bloemer, MJ Scalora, M AF Mattiucci, N D'Aguanno, G Bloemer, MJ Scalora, M TI Second-harmonic generation from a positive-negative index material heterostructure SO PHYSICAL REVIEW E LA English DT Article ID REFRACTION; MODE; PROPAGATION; MEDIA AB Resonant cavities have been widely used in the past to enhance material, nonlinear response. Traditional mirrors include metallic films and distributed Bragg reflectors. In this paper we propose negative index material mirrors as a third alternative. With the help of a rigorous Green function approach, we investigate second harmonic generation from single and coupled cavities, and theoretically prove that negative index material mirrors can raise the nonlinear conversion efficiency of a bulk material by at least four orders of magnitude compared to a bulk medium. C1 Time Domain Corp, Huntsville, AL 35806 USA. Univ RomaTre, Dipartimento Fis E Amaldi, I-00146 Rome, Italy. USA, Charles M Bowden Res Facil, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. RP Time Domain Corp, Cummings Res Pk,7057 Old Madison Pike, Huntsville, AL 35806 USA. OI D'Aguanno, Giuseppe/0000-0002-7132-0103 NR 23 TC 31 Z9 32 U1 1 U2 1 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD DEC PY 2005 VL 72 IS 6 AR 066612 DI 10.1103/PhysRevE.72.066612 PN 2 PG 8 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 008UA UT WOS:000235065000089 PM 16486083 ER PT J AU Deyle, GD Allison, SC Matekel, RL Ryder, MG Stang, JM Gohdes, DD Hutton, JP Henderson, NE Garber, MB AF Deyle, GD Allison, SC Matekel, RL Ryder, MG Stang, JM Gohdes, DD Hutton, JP Henderson, NE Garber, MB TI Physical therapy treatment effectiveness for osteoarthritis of the knee: A randomized comparison of supervised clinical exercise and manual therapy procedures versus a home exercise program SO PHYSICAL THERAPY LA English DT Article DE exercise; knee osteoarthritis; manual therapy; physical therapy ID CONTROLLED-TRIAL; COX-2 INHIBITORS; OLDER-ADULTS; DOUBLE-BLIND; RISK-FACTORS; HAMSTRING MUSCLES; FRAMINGHAM OSTEOARTHRITIS; ARTHROSCOPIC SURGERY; ACTIVATION FAILURE; NATURAL-HISTORY AB Background and Purpose. Manual therapy and exercise have not previously been compared with a home exercise program for patients with osteoarthritis (OA) of the knee. The purpose of this study was to compare outcomes between a home-based physical therapy program and a clinically based physical therapy program. Subjects. One hundred thirty-four subjects with OA of the knee were randomly assigned to a clinic treatment group (n=66; 61% female, 39% male; mean age [+/- SD] = 64 +/- 10 years) or a home exercise group (n = 68, 71 % female, 29% male; mean age [ SD]=62: :9 years). Methods. Subjects in the clinic treatment group received supervised exercise, individualized manual therapy, and a home exercise program over a 4-week period. Subjects in the home exercise group received the same home exercise program initially, reinforced at a clinic visit 2 weeks later. Measured outcomes were the distance walked in 6 minutes and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results. Both groups showed clinically and statistically significant improvements in 6-minute walk distances and WOMAC scores at 4 weeks; improvements were still evident in both groups at 8 weeks. By 4 weeks, WOMAC scores had improved by 52% in the clinic treatment group and by 26% in the home exercise group. Average 6-minute walk distances had improved about 10% in both groups. At 1 year, both groups were substantially and about equally improved over baseline measurements. Subjects in the clinic treatment group were less likely to be taking medications for their arthritis and were more satisfied with the overall outcome of their rehabilitative treatment compared with subjects in the home exercise group. Discussion and Conclusion. Although both groups improved by 1 month, subjects in the clinic treatment group achieved about twice as much improvement in WOMAC scores than subjects who performed similar unsupervised exercises at home. Equivalent maintenance of improvements at 1 year was presumably due to both groups continuing the identical home exercise program. The results indicate that a home exercise program for patients with OA of the knee provides important benefit. Adding a small number of additional clinical visits for the application of manual therapy and supervised exercise adds greater symptomatic relief [Deyle GD, Allison SC, Matekel RL, et al. Physical therapy treatment effectiveness for osteoarthritis of the knee: a randomized comparison of supervised clinical exercise and manual therapy procedures versus a home exercise program. C1 Rocky Mt Univ Hlth Profess, Provo, UT USA. Baylor Univ, Waco, TX 76798 USA. Baylor Univ, USA, Senior Fac,Brooke Army Med Ctr, Post Profess Doctoral Program Othropaed Manual Ph, San Antonio, TX USA. Elon Univ, Elon College, NC USA. Madigan Army Med Ctr, Ft Lewis, WA USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Army Specialist Corps, Ft Sam Houston, TX 78234 USA. Army Med Specialist Corps, Ft Lewis, WA USA. Ireland Army Community Hosp, Ft Knox, KY USA. Army Med Specialist Corps, Ft Knox, KY USA. Tripler Army Med Ctr, Tripler, HI USA. Army Med Specialist Corps, Tripler, HI USA. Eisenhower Army Med Ctr, Ft Gordon, GA USA. Army Med Specialist Corps, Ft Gordon, GA USA. RP Deyle, GD (reprint author), 3 Sherborne Ward, San Antonio, TX 78218 USA. EM gdeyle@satx.rr.com NR 92 TC 134 Z9 143 U1 3 U2 27 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD DEC PY 2005 VL 85 IS 12 BP 1301 EP 1317 PG 17 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 997RG UT WOS:000234264300004 PM 16305269 ER PT J AU Harris, KD Heer, DM Roy, TC Santos, DM Whitman, JM Wainner, RS AF Harris, KD Heer, DM Roy, TC Santos, DM Whitman, JM Wainner, RS TI Reliability of a measurement of neck flexor muscle endurance SO PHYSICAL THERAPY LA English DT Article; Proceedings Paper CT Annual Conference of the American-Academy-of-Orthopaedic-Manual-Physical-Therapists CY OCT 03-06, 2003 CL Orlando, FL SP Amer Acad Orthopaed Manual Phys Therapists DE cervical impairment; cervical pain; chin tuck; deep neck flexors ID CERVICAL HEADACHE; LONGUS-COLLI; PERFORMANCE; DYSFUNCTION; STRENGTH; PAIN; VALIDITY; TRIAL; INDEX AB Background and Purpose. Neck flexor muscle endurance has been negatively correlated with cervical pain and dysfunction. The purposes of this study were to determine rater reliability in subjects both with and without neck pain and to determine whether there was a difference in neck flexor muscle endurance between the 2 groups. Subjects. Forty-one subjects with and without neck pain were enrolled in this repeated-measures reliability study. Methods. Two raters used an isometric neck retraction test to assess neck flexor muscle endurance for all subjects during an initial session, and subjects without neck pain returned for testing 1 week later. Results. For the group without neck pain, intrarater reliability was good to excellent (intraclass correlation coefficient [ICC (3,1)] =.82-.91), and interrater reliability was moderate to good (ICC[2,l]=.67-.78). The associated standard error of measurement (SEM) ranged from 8.0 to 11.0 seconds and from 12.6 to 15.3 seconds, respectively. For the group with neck pain, interrater reliability was moderate (ICC[2,1] =.67, SEM=11.5). Neck flexor muscle endurance test results for the group without neck pain (X=38.95 seconds, SD=26.4) and the group with neck pain (R=24.1 seconds, SD=12.8) were significantly different. Discussion and Conclusion. Reliability coefficients differed between the 2 groups and ranged from moderate to excellent and improved after the first test session. The interrater reliability of data obtained with the neck flexor muscle endurance test in people with neck pain must be improved in order for clinicians to distinguish a clinically meaningful change from measurement error. Neck flexor muscle endurance was both statistically and clinically greater for subjects without neck pain than for those with neck pain. [Harris KD, Heer DM, Roy TC, et al. Reliability of a measurement of neck flexor muscle endurance. C1 USA, Baylor Grad Program Phys Therapy, San Antonio, TX USA. Regis Univ, Denver, CO USA. Baylor Univ, USA, Postprofess Doctoral Program Othopaed & Manual Ph, Waco, TX 76798 USA. RP Harris, KD (reprint author), Troop Med Clin 10, Special Forces Grp Airborne 10, 7490 Sutherland Cir, Ft Carson, CO 80913 USA. EM kevin.harris@cen.amedd.army.mil NR 22 TC 59 Z9 59 U1 0 U2 7 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD DEC PY 2005 VL 85 IS 12 BP 1349 EP 1355 PG 7 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 997RG UT WOS:000234264300008 PM 16305273 ER PT J AU Tatsimo, SJN Tane, P Srinivas, PV Sondengam, BL Melissa, J Okunji, CO Schuster, BM Iwu, MM Khan, IA AF Tatsimo, SJN Tane, P Srinivas, PV Sondengam, BL Melissa, J Okunji, CO Schuster, BM Iwu, MM Khan, IA TI Novel antimicrobial diterpenoids from Turraeanthus africanus SO PLANTA MEDICA LA English DT Article DE Turraeanthus africanus; Meliaceae; antimicrobial activity; diterpenes; labdanes; turraeanin ID MELIACEAE AB The dichloromethane-methanol (1/1) extract of the stem bark of Turraeanthus africanus (Meliaceae) showed remarkable antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus. Phytochemical investigation of this extract afforded six new diterpenoid derivatives, (+)-16-acetoxy-12,15-epoxylabda-8(17),12,14-triene (3), [16(E), 12S,15R]-16-acetoxy-12,15-epoxy-15-isopropoxy-ent-labda-8(17), 13(16)-diene (turraeanin A, 4),[16(E),12R,15S]-16-acetoxy-12,15-epoxy- 15-isopropoxy-ent-labda-8(17),13(16)-diene (turraeanin B, 5), [16(E),12S,15R]-16-acetoxy-12,15-epoxy-15-methoxy-entlabda-8(17),13(16)-diene (turraeanin C, 6), [16(E),12R,15S]-16-acetoxy-12,15-epoxy-15-methoxy-ent-labda-8(17),13(16)-diene (turraeanin D, 7) and (12S,13S,15R)-12,15-epoxy-15-methoxyent-labd-8(17)-en-16-al (turraeanin E, 9) together with the known compounds, 15,16-epoxy-etit-labda-8(17),13(16),14-triene (1), (+)-pumiloxide (2), ent-labda-8(17),12 (E)-diene-15,16-dial (8) and 16-acetoxy-12(R),15-epoxy-15 beta-hydroxylabda-8(17), 13 (16)-diene (10). Compound 10 was obtained as its acetoxy derivative (10a) and compound 11 was the product of hydrolysis of 6. Antimicrobial activity of the isolates was assayed and compounds 8, 9, 10a and 11 exhibited significant activities. C1 Univ Dschang, Dept Chem, Dschang, Cameroon. Univ Yaounde, Dept Organ Chem, Yaounde, Cameroon. Univ Mississippi, Natl Ctr Nat Prod Res, University, MS USA. Int Ctr Ethnomed & Drug Dev, Nsukka, Nigeria. Bioresources Dev & Conservat Programme, Silver Spring, MD USA. Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC USA. RP Tane, P (reprint author), Univ Dschang, Dept Chem, Box 67, Dschang, Cameroon. EM ptane@yahoo.com FU FIC NIH HHS [TW03004] NR 14 TC 11 Z9 11 U1 0 U2 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0032-0943 J9 PLANTA MED JI Planta Med. PD DEC PY 2005 VL 71 IS 12 BP 1145 EP 1151 DI 10.1055/s-2005-873164 PG 7 WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine GA 004DE UT WOS:000234731400010 PM 16395652 ER PT J AU Mutabingwa, TK Bolla, MC Li, JL Domingo, GJ Li, XH Fried, M Duffy, PE AF Mutabingwa, TK Bolla, MC Li, JL Domingo, GJ Li, XH Fried, M Duffy, PE TI Maternal malaria and gravidity interact to modify infant susceptibility to malaria SO PLOS MEDICINE LA English DT Article ID CHONDROITIN SULFATE-A; PLASMODIUM-FALCIPARUM MALARIA; BIRTH-WEIGHT; T-CELLS; HUMAN PLACENTA; WESTERN KENYA; RISK-FACTORS; PREGNANCY; INFECTION; ANEMIA AB Background In endemic areas, placental malaria due to Plasmodium falciparum is most frequent and severe in first-time mothers, and increases the risk of infant mortality in their offspring. Placental malaria may increase the susceptibility of infants to malaria parasitemia, but evidence for this effect is inconclusive. Methods and Findings During 2002-2004, we monitored parasitemia in 453 infants, including 69 who were born to mothers with placental malaria, in a region of northeastern Tanzania where malaria transmission is intense. We used a Cox proportional hazards model to evaluate the time from birth to first parasitemia, and a generalized estimating equations logistic regression model to evaluate risk of any parasitemia throughout the first year of life. Compared with infants whose mothers did not have placental malaria at delivery ("PM-negative"), offspring of mothers with placental malaria at delivery ("PM-positive") were 41% more likely to experience their first parasitemia at a younger age (adjusted hazard ratio [AHR] = 1.41, 95% confidence interval [CI] 1.01-1.99). The odds of parasitemia throughout infancy were strongly modified by the interaction between placental malaria and gravidity (p for interaction = 0.008, Type 3 likelihood ratio test). Offspring of PM-negative primigravidae had lower odds of parasitemia during infancy (adjusted odds ratio [AOR] = 0.67, 95% Cl 0.50-0.91) than offspring of PM-negative multigravidae, and offspring of PM-positive primigravidae had the lowest odds (AOR = 0.21, 95% Cl 0.09-0.47). In contrast, offspring of PM-positive multigravidae had significantly higher odds of parasitemia (AOR = 1.59, 95% Cl 1.16-2.17). Conclusion Although parasitemia is more frequent in primigravid than multigravid women, the converse is true in their offspring, especially in offspring of PM-positive women. While placental malaria is known to increase mortality risk for first-born infants, it surprisingly reduced their risk of parasitemia in this study. Placental malaria of multigravidae, on the other hand, is a strong risk factor for parasitemia during infancy, and therefore preventive antimalarial chemotherapy administered to multigravid women close to term may reduce the frequency of parasitemia in their offspring. C1 Seattle Biomed Res Inst, MOMS Project, Malaria Antigen Discovery Program, Seattle, WA 98109 USA. London Sch Hyg & Trop Med, London WC1, England. Muheza Designated Dist Hosp, Natl Inst Med Res, Muheza, Tanzania. Fred Hutchinson Canc Res Ctr, Dept Publ Hlth Sci, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, MOMS Project, Malaria Antigen Discovery Program, 4 Nickerson St, Seattle, WA 98109 USA. EM pduffy@sbri.org FU FIC NIH HHS [TW 05509, D43 TW005509]; NIAID NIH HHS [R01 AI 52059, R01 AI052059] NR 34 TC 94 Z9 94 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD DEC PY 2005 VL 2 IS 12 BP 1260 EP 1268 AR e407 DI 10.1371/journal.pmed.0020407 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 003XD UT WOS:000234714700014 PM 16259531 ER PT J AU Liu, X Engel, CC Kang, H Cowan, D AF Liu, X Engel, CC Kang, H Cowan, D TI The effect of veteran status on mortality among older Americans and its pathways SO POPULATION RESEARCH AND POLICY REVIEW LA English DT Article DE differential mortality; older veterans; structural equation models; survival analysis ID VIETNAM VETERANS; ARMY; LIFE; POPULATIONS; CROSSOVER; STRESS; MODELS; HEALTH; DEATH; RISK AB This research examines excess mortality among American veterans age 70 years or older during a two-to-three year interval from 1993/94 to the end of 1995. Using a structural hazard rate model, we analyzed data on a sample of respondents age 70 or over from the Survey of Asset and Health Dynamics among the Oldest Old (AHEAD). We found that at age 70, older veterans have a slightly higher death rate than their nonveteran counterparts, implying a mortality crossover right before this age. Such excess mortality among veterans increases considerably with age, when other factors are held equal. The direct and indirect effects of veteran status on mortality by means of physical and mental health mostly perform in opposite directions, and such effects vary greatly in magnitude and direction as a function of age. The intervening effects of physical and mental health status decrease substantially with increasing age. Many of the mechanisms inherent in the excess mortality among older veterans are not captured by variations in their health status, especially among the oldest-old. A more extensive study on this topic is urgently needed. C1 Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Psychiat, Bethesda, MD 20814 USA. Environm Epidemiol Serv, Dept Vet Affairs, Washington, DC 20420 USA. RP Liu, X (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. EM xian.liu@na.amedd.army.mil NR 34 TC 11 Z9 11 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-5923 J9 POPUL RES POLICY REV JI Popul. Res. Policy Rev. PD DEC PY 2005 VL 24 IS 6 BP 573 EP 592 DI 10.1007/s11113-005-5056-3 PG 20 WC Demography SC Demography GA 009UI UT WOS:000235138500002 ER PT J AU Maccarelli, FJ Shenenberger, DW AF Maccarelli, Frank J. Shenenberger, Donald W. TI Koebner's phenomenon Skin trauma may trigger psoriatic flares SO POSTGRADUATE MEDICINE LA English DT Article C1 [Maccarelli, Frank J.] USN, Silver Spring, MD 20906 USA. [Shenenberger, Donald W.] Natl Naval Med Ctr, Natl Capital Consortium Dermatol Residency Progra, Bethesda, MD USA. [Shenenberger, Donald W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Shenenberger, DW (reprint author), USN, 2220 Cherry Leaf Ln, Silver Spring, MD 20906 USA. EM dwshenenberger@bethesda.med.navy.mil NR 4 TC 0 Z9 0 U1 0 U2 1 PU JTE MULTIMEDIA PI BERWYN PA 1235 WESTLAKES DR, STE 220, BERWYN, PA 19312 USA SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD DEC PY 2005 VL 118 IS 6 BP 45 EP 46 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA V10JK UT WOS:000207460100010 PM 16382765 ER PT J AU Brown, KS Folen, RA AF Brown, KS Folen, RA TI Psychologists as leaders of multidisciplinary chronic pain management teams: A model for health care delivery SO PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE LA English DT Article DE pain management; multidisciplinary; teams; team leader ID CHRONIC NONMALIGNANT PAIN; LOW-BACK-PAIN; BEHAVIORAL MEDICINE; FUTURE-DIRECTIONS; COX-2 INHIBITORS; REHABILITATION; COLLABORATION; OPPORTUNITIES; PHYSICIANS; OBSTACLES AB Psychologists have the potential to improve the quality of life of chronic pain patients by intervening not only through direct services but also by using their training for promoting proactive leadership in multidisciplinary teams and in the larger health care environment. To significantly impact pain management, psychologists must not only deliver state-of-the-art care but also take an active role in directing the design, implementation, and evaluation of these programs. C1 Tripler Army Med Ctr, Dept Psychol, Pain Rehabil Program, Honolulu, HI 96859 USA. RP Brown, KS (reprint author), Tripler Army Med Ctr, Dept Psychol, Pain Rehabil Program, Honolulu, HI 96859 USA. EM kathleen.brown@haw.tamc.amedd.army.mil NR 78 TC 7 Z9 7 U1 1 U2 7 PU AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0735-7028 J9 PROF PSYCHOL-RES PR JI Prof. Psychol.-Res. Pract. PD DEC PY 2005 VL 36 IS 6 BP 587 EP 594 DI 10.1037/0735-7028.36.6.587 PG 8 WC Psychology, Multidisciplinary SC Psychology GA 000BZ UT WOS:000234437200001 ER PT J AU Cho, SG Cho, JR Goh, EM Kim, JK Damavarapu, R Surapaneni, R AF Cho, SG Cho, JR Goh, EM Kim, JK Damavarapu, R Surapaneni, R TI Synthesis and characterization of 4,4 ',5,5 '-tetranitro-2,2 '-bi-1H-imidazole (TNBI) SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE explosive molecule; synthesis; impact sensitivity; chemical characterization; tetranitrobiimidazole AB We synthesized 4,4',5,5'-tetranitro-2,2'-bi-1H-imidazole (TNBI), which may serve as a new energetic filler for high explosive formulations. TNBI was synthesized by treating an excess amount of sodium nitrate with 2,2'-bi-1H-imidazole (BI), which was produced from glyoxal and ammonia gas. The overall synthetic yield was 32%. ne synthesized TNBI was characterized by performing various chemical analyses including NMR, IR, and CHN analyses. Small scale sensitivity tests were carried out at both research institutes (ADD and ARDEC). The sensitivity results varied from 'more sensitive than RDX' to 'substantially less sensitive than RDX' according to the purity and conditions of the test samples. Based on our careful characterizations, this large variation in sensitivity was attributed to the moisture content that was present in the test samples due to a hygroscopic nature of TNBI. We also found that the hygroscopic nature of TNBI changed significantly due to the amount of impurities, especially sulfates. C1 Agcy Def Dev, High Explos Team, Taejon 305600, South Korea. USA, Explos Res & Technol Branch, Armament RD&E Ctr, Picatinny Arsenal, NJ 07806 USA. RP Cho, SG (reprint author), Agcy Def Dev, High Explos Team, POB 35-5, Taejon 305600, South Korea. EM soocho@add.re.kr NR 14 TC 36 Z9 36 U1 0 U2 5 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD DEC PY 2005 VL 30 IS 6 BP 445 EP 449 DI 10.1002/prep.200500040 PG 5 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 000CJ UT WOS:000234438200011 ER PT J AU Forsten, R Schneider, B AF Forsten, R Schneider, B TI Treatment of the stress casualty during Operation Iraqi Freedom one SO PSYCHIATRIC QUARTERLY LA English DT Article DE Operation Iraqi Freedom; echelons of care; Combat Stress Control; Division Mental Health; Combat Support Hospital AB Introduction: Service members with mental health issues during Operation Iraqi Freedom receive evaluation and treatment at different echelons of care. Mental health teams consist of professionals and paraprofessionals assigned to Combat Stress Control units, Division Mental Health Sections, and Combat Support Hospitals. Methods: Army doctrine for mental health care is delineated and examples describing how mental health personnel must be flexible in this challenging environment and are useful mental health tools for commanders in the operational environment are presented. Discussion: Specific treatment issues related to the combat environment during Operation Iraqi Freedom are discussed in relation to each team and in light of doctrine. C1 Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. RP Forsten, R (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM robert.forsten@us.army.mil NR 4 TC 4 Z9 5 U1 0 U2 0 PU KLUWER ACADEMIC-HUMAN SCIENCES PRESS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 0033-2720 J9 PSYCHIAT QUART JI Psychiatr. Q. PD WIN PY 2005 VL 76 IS 4 BP 343 EP 350 DI 10.1007/s11126-005-4968-9 PG 8 WC Psychiatry SC Psychiatry GA 978PR UT WOS:000232886000005 PM 16217629 ER PT J AU Wain, H Bradley, J Nam, T Waldrep, D Cozza, S AF Wain, H Bradley, J Nam, T Waldrep, D Cozza, S TI Psychiatric interventions with returning soldiers at Walter Reed SO PSYCHIATRIC QUARTERLY LA English DT Article DE psychiatric intervention; trauma; casualties AB War is a malefic force and results in many psychiatric and medical casualties. Psychiatry's involvement with soldiers experiencing psychological stress resulting from combat experience has been reported for many years (Zajtchuk, 1995). It has been demonstrated that a myriad of diagnosis to include depression, anxiety, somatoform, adjustment disorders and psychotic behaviors also emerge (Wain et al., 1996, 2005a). Nearly all survivors exposed to traumatic events briefly exhibit one or more stress related symptoms (Morgan et al., 2003). In many instances these symptoms dissipate within a reasonable amount of time. However, symptoms persisting for a prolonged period following a traumatic event increase the probability of developing stress-related psychiatric disorders. C1 Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. RP Wain, H (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM harold.wain@na.amedd.army.mil NR 8 TC 7 Z9 7 U1 0 U2 0 PU KLUWER ACADEMIC-HUMAN SCIENCES PRESS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 0033-2720 J9 PSYCHIAT QUART JI Psychiatr. Q. PD WIN PY 2005 VL 76 IS 4 BP 351 EP 360 DI 10.1007/s11126-005-4971-0 PG 10 WC Psychiatry SC Psychiatry GA 978PR UT WOS:000232886000006 PM 16217630 ER PT J AU Cozza, SJ Chun, RS Polo, JA AF Cozza, SJ Chun, RS Polo, JA TI Military families and children during Operation Iraqi Freedom SO PSYCHIATRIC QUARTERLY LA English DT Article DE military family; military child; military deployment; combat injury; combat death ID DESERT-STORM; SECONDARY TRAUMATIZATION; VIETNAM VETERANS; WAR; SEPARATION; STRESS; TRAUMA AB The general public has become increasingly interested in the health and well being of the children and families of military service members as the war in Iraq continues. Observers recognize the potential stresses or traumas that this population might undergo as a result of the military deployment or the possible injury or death of military family members. While such concern is welcomed, it is sometimes misplaced. Not infrequently, conclusions that are drawn are fraught with misunderstanding and bias based upon lack of understanding of the military community or a preconceived notion of the vulnerabilities of the population. This problem is compounded by the paucity of scientific study. In this article the authors review the strengths of military families as well as the unique challenges that they face. The authors also highlight parental deployment, parental injury and parental death as unique stresses to military children and families. Available and pertinent scientific information is reviewed. Clinical observations of children and families during the ongoing war in Iraq are presented. C1 Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. RP Cozza, SJ (reprint author), Walter Reed Army Med Ctr, Dept Psychiat, 6900 Georgia Ave, Washington, DC 20307 USA. EM stephen.cozza@us.army.mil NR 16 TC 83 Z9 83 U1 3 U2 10 PU KLUWER ACADEMIC-HUMAN SCIENCES PRESS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 0033-2720 J9 PSYCHIAT QUART JI Psychiatr. Q. PD WIN PY 2005 VL 76 IS 4 BP 371 EP 378 DI 10.1007/s11126-005-4973-y PG 8 WC Psychiatry SC Psychiatry GA 978PR UT WOS:000232886000008 PM 16217632 ER PT J AU Barthelemy, P Lee, SJ Grinstaff, M AF Barthelemy, P Lee, SJ Grinstaff, M TI Supramolecular assemblies with DNA SO PURE AND APPLIED CHEMISTRY LA English DT Article; Proceedings Paper CT 7th IUPAC International Conference on Heteroatom Chemistry CY AUG 21-25, 2004 CL Shanghai, PEOPLES R CHINA SP IUPAC DE supramolecular assemblies; DNA; amphiphiles; nucleoside; nucleic acid transport; nucleoside-based lipids ID PEPTIDE NUCLEIC-ACIDS; MOLECULAR RECOGNITION CAPABILITIES; CATIONIC LIPOSOME REAGENT; NONVIRAL GENE DELIVERY; BINDING-AFFINITY; IN-VITRO; FLUORINATED LIPOPLEXES; SELF-ORGANIZATION; MAMMALIAN-CELLS; SALT SURFACTANT AB Information storage in chemical and biological systems involves recognition processes occurring at the molecular and macromolecular level. The implementation of a "code" can consist of multiple noncovalent interactions, which include hydrogen bonds, pi-stacking, hydrophobic interactions, and appropriate molecular and supramolecular architectures. With the double-helical DNA structure stabilized by Watson-Crick hydrogen bond base-pairing and aryl pi-pi stacking interactions, nature provides to scientists an example of one of the most sophisticated supramolecular systems. Molecular organization using these types of processes has become a very powerful strategy for the construction of well-defined nanostructures. Self-assemblies using noncovalent interactions have been designed to build fibers, membranes, two-dimensional monolayers, hydro, organo gels, etc. This paper highlights the research presented at the workshop entitled DNA Supramolecular Assemblies, which was held in Avignon, France on 5-6 May 2004. In this article. we first focus on the recent progress achieved in the design of supramolecular self-assemblies that mimic the molecular recognition functionalities found with nucleic acids. Second, we present several synthetic-DNA supramolecular assemblies currently developed to transport nucleic acids into cells. The marriage of supramolecular chemistry with nucleic acids as illustrated through examples in this article will open new avenues for designing artificial molecular devices and expand the current repertoire of supramolecular assemblies available. C1 Fac Sci Avignon, F-84000 Avignon, France. USA, Res Off, Res Triangle Pk, NC 27709 USA. Boston Univ, Dept Chem, Metcalf Ctr Sci & Engn, Boston, MA 02215 USA. Boston Univ, Dept Biomed Engn, Metcalf Ctr Sci & Engn, Boston, MA 02215 USA. RP Barthelemy, P (reprint author), Univ Bordeaux 2, INSERM, U386, 146 Leo Saignat Bat 3A, F-33076 Bordeaux, France. NR 94 TC 19 Z9 19 U1 2 U2 15 PU INT UNION PURE APPLIED CHEMISTRY PI RES TRIANGLE PK PA 104 TW ALEXANDER DR, PO BOX 13757, RES TRIANGLE PK, NC 27709-3757 USA SN 0033-4545 J9 PURE APPL CHEM JI Pure Appl. Chem. PD DEC PY 2005 VL 77 IS 12 BP 2133 EP 2148 DI 10.1351/pac200577122133 PG 16 WC Chemistry, Multidisciplinary SC Chemistry GA 996HD UT WOS:000234164100020 ER PT J AU Patterson, HS Sponaugle, DN AF Patterson, HS Sponaugle, DN TI On using the term infiltrate in radiography reports - Response SO RADIOLOGY LA English DT Letter C1 Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Patterson, HS (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 16000 Georgia Ave, Washington, DC 20307 USA. EM harlan.patterson@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD JAN PY 2005 VL 237 IS 3 BP 1124 EP 1124 DI 10.1148/radiol.2373051267 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 985LV UT WOS:000233380100055 ER PT J AU Harmar, OP Clifford, NJ Thorne, CR Biedenharn, DS AF Harmar, OP Clifford, NJ Thorne, CR Biedenharn, DS TI Morphological changes of the Lower Mississippi River: Geomorphological response to engineering intervention SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE fluvial dynamics; morphological response; lower Mississippi river ID RIFFLE-POOL SEQUENCES; LOUISIANA; USA AB During the twentieth century, the planform and profile of the Lower Mississippi River from Cairo, Illinois, to New Orleans, Louisiana, have been transformed by a series of engineering modifications. These include steepening of the long profile by removal of the most sinuous bends, extensive bank stabilization, and regulating sediment movement by dyke field construction. Prior to these modifications, the Lower Mississippi River adjusted its morphology in the planform, long profile and cross-section. Planform adjustment has, however, effectively been negated and other adjustments are now constrained. Nevertheless, analysis of hydrographic surveys between 1949 and 1989 demonstrates that geomorphological response during the post-cutoff period remained complex. Morphological adjustments involved phased patterns of aggradation and degradation, together with changes in cross-sectional form, and in the number, size, location and shape of pools and crossings. Greatest changes occurred in the early post-cutoff period (1949-64) upstream from Vicksburg, Mississippi, but were accompanied by complementary changes elsewhere which propagated downstream. The combined set of responses may be interpreted with respect to a dynamic equilibrium in which the river responded to additional energy created by the cutoffs by increasing and adapting flow resistance over various scales and time periods. This study helps resolve paradoxes from previous analyses, and has significance for interpreting past engineering impacts and for suggesting future management strategies for the Lower Mississippi River. Copyright (c) 2005 John Wiley & Sons, Ltd. C1 Univ Nottingham, Sch Geog, Nottingham NG7 2RD, England. USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Harmar, OP (reprint author), Univ Nottingham, Sch Geog, Nottingham NG7 2RD, England. EM Oliver.Harmar@nottingham.ac.uk NR 62 TC 18 Z9 18 U1 4 U2 18 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1535-1459 J9 RIVER RES APPL JI River Res. Appl. PD DEC PY 2005 VL 21 IS 10 BP 1107 EP 1131 DI 10.1002/rra.887 PG 25 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 000LI UT WOS:000234462900004 ER PT J AU Adams, BD Rickett, D Albaneze, PA Jones, MD York, G AF Adams, BD Rickett, D Albaneze, PA Jones, MD York, G TI Pinch-an-inch test for appendicitis SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE rebound tenderness; appendicitis; peritoneum; McBurney's point ID REBOUND TENDERNESS; DELAY AB Rebound tenderness is a widely used examination technique for patients with suspected appendicitis, but it can be quite uncomfortable. An alternative test for peritonitis is termed the "pinch-an-inch" test. This report describes two patients who presented with mild abdominal pain who subsequently were found to have appendicitis. In both patients, classic peritoneal signs were absent, but the pinch-an-inch test was positive. The experienced physician's bedside clinical examination remains the most critical component for rapidly identifying peritonitis. Although rebound tenderness is a widely used examination, it is uncomfortable and may be inaccurate. To perform the pinch-an-inch test, a fold of abdominal skin over McBurney's point is grasped and elevated away from the peritoneum. The skin is allowed to recoil back briskly against the peritoneum. If the patient has increased pain when the skin fold strikes the peritoneum, the test is positive and peritonitis probably is present. C1 Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. RP Adams, BD (reprint author), Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. EM bruce.adams@amedd.army.mil NR 12 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD DEC PY 2005 VL 98 IS 12 BP 1207 EP 1209 DI 10.1097/01.smj.0000189905.55017.67 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 998LM UT WOS:000234320200013 PM 16440921 ER PT J AU Whited, JD Datta, SK Aiello, LM Aiello, LP Cavallerano, JD Conlin, PR Horton, MB Vigersky, RA Poropatich, RK Challa, P Darkins, AW Bursell, SE AF Whited, JD Datta, SK Aiello, LM Aiello, LP Cavallerano, JD Conlin, PR Horton, MB Vigersky, RA Poropatich, RK Challa, P Darkins, AW Bursell, SE TI A modeled economic analysis of a digital teleophthalmology system as used by three federal healthcare agencies for detecting proliferative diabetic retinopathy SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article AB The objective of this study was to compare, using a 12-month time frame, the cost-effectiveness of a nonmydriatic digital teleophthalmology system (Joslin Vision Network) versus traditional clinic-based ophthalmoscopy examinations with pupil dilation to detect proliferative diabetic retinopathy and its consequences. Decision analysis techniques, including Monte Carlo simulation, were used to model the use of the Joslin Vision Network versus conventional clinic-based ophthalmoscopy among the entire diabetic populations served by the Indian Health Service, the Department of Veterans Affairs, and the active duty Department of Defense. The economic perspective analyzed was that of each federal agency. Data sources for costs and outcomes included the published literature, epidemiologic data, administrative data, market prices, and expert opinion. Outcome measures included the number of true positive cases of proliferative diabetic retinopathy detected, the number of patients treated with panretinal laser photocoagulation, and the number of cases of severe vision loss averted. In the base-case analyses, the Joslin Vision Network was the dominant strategy in all but two of the nine modeled scenarios, meaning that it was both less costly and more effective. In the active duty Department of Defense population, the Joslin Vision Network would be more effective but cost an extra $1,618 per additional patient treated with panretinal laser photo-coagulation and an additional $13,748 per severe vision loss event averted. Based on our economic model, the Joslin Vision Network has the potential to be more effective than clinic-based ophthalmoscopy for detecting proliferative diabetic retinopathy and averting cases of severe vision loss, and may do so at lower cost. C1 Vet Adm Med Ctr, Ctr Hlth Serv Res Primary Care, Durham, NC 27705 USA. Duke Univ, Med Ctr, Div Gen Internal Med, Durham, NC 27710 USA. Harvard Univ, Sch Med, Joslin Diabet Ctr, Beetham Eye Inst, Boston, MA 02115 USA. Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA USA. Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA. Vet Affairs Boston Healthcare Syst, Boston, MA USA. Indian Hlth Serv, Eye Dept, Phoenix Indian Med Ctr, Phoenix, AZ USA. Walter Reed Army Med Ctr, Serv Endocrinol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Telemed Directorate, Washington, DC 20307 USA. Duke Univ, Med Ctr, Dept Ophthalmol, Durham, NC 27710 USA. Vet Healthcare Adm Telemed Strateg Healthcare Grp, Washington, DC USA. RP Whited, JD (reprint author), Vet Adm Med Ctr, Ctr Hlth Serv Res Primary Care, 152,Bldg 6,508 Fulton St, Durham, NC 27705 USA. EM white046@mc.duke.edu FU NIDDK NIH HHS [K24DK63214] NR 24 TC 45 Z9 46 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD DEC PY 2005 VL 11 IS 6 BP 641 EP 651 DI 10.1089/tmj.2005.11.641 PG 11 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 011PF UT WOS:000235279900019 PM 16430383 ER PT J AU Brassell, SA Kao, TC Sun, L Moul, JW AF Brassell, SA Kao, TC Sun, L Moul, JW TI Prostate-specific antigen versus prostate-specific antigen density as predictor of tumor volume, margin status, pathologic stage, and biochemical recurrence of prostate cancer SO UROLOGY LA English DT Article ID RADICAL PROSTATECTOMY; CORRELATE AB Objectives. To compare prostate-specific antigen (PSA) and PSA density (PSAD) calculated by transrectal ultrasound (TRUS) volume (TRUS PSAD), pathologic volume (Path PSAD), and weight (Weight PSAD) for their ability to predict pathologic characteristics and biochemical recurrence of prostate cancer. We also compared all PSAD derivatives to determine consistency. Methods. Between 1993 and 2002, 306 patients were retrospectively identified who had had PSAD determined preoperatively by TRUS and subsequently underwent radical prostatectomy with whole mounting and close step sectioning. The determination of stage, margin status, tumor number, individual tumor volume, and total tumor volume was obtained from the pathologic evaluation. Clinical follow-up was available for 265 patients. Results. The mean patient age was 62 years, the median Gleason score was 7, the median PSA level was 5.80 ng/mL, and the median TRUS PSAD was 0.16. The percentages of concordance for PSA, TRUS PSAD, Path PSAD, and Weight PSAD were similar in predicting margin status and extracapsular extension. Using linear regression analysis, PSA was more efficacious than TRUS PSAD, Path PSAD, or Weight PSAD in predicting the total tumor volume (R-2 0.11, 0.08, 0.04, and 0.06, respectively). A significant positive correlation was found among TRUS PSAD, Path PSAD, and Weight PSAD. PSA was significantly better in predicting biochemical recurrence than TRUS, Path, or Weight PSAD (concordance 75.5%, 66.6%, 66.5%, and 70.4%, respectively). Conclusions. PSA and TRUS PSAD are significant and equivalent predictors of margin status and extracapsular extension. A marked difference may exist between PSA and TRUS PSAD in predicting the total tumor volume and biochemical recurrence. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Div Epidemiol & Biostat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Surg, Serv Urol, Washington, DC 20307 USA. RP Brassell, SA (reprint author), 1 Hermann Museum Circle,Apt 2084, Houston, TX 77004 USA. EM stephen.brassell@us.army.mil NR 15 TC 25 Z9 28 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD DEC PY 2005 VL 66 IS 6 BP 1229 EP 1233 DI 10.1016/j.urology.2005.06.106 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 995UR UT WOS:000234130200020 PM 16360448 ER PT J AU Cuda, SP Vanasupa, BP Sutherland, RS AF Cuda, SP Vanasupa, BP Sutherland, RS TI Nonoperative management of a patent urachus SO UROLOGY LA English DT Article ID ANOMALIES AB Patent urachus accounts for 10% to 15% of all reported urachal abnormalities in the literature. Treatment in the past has relied on immediate surgery. Conservative therapy with bladder catheter drainage, resulting in spontaneous closure, has not been described. We report a case of patent urachus in a 6-day-old infant who presented with urine drainage from the umbilicus. Radiographic studies confirmed a patent urachus. One week of urethral catheterization resulted in spontaneous closure of the patent urachus. This case suggests that initial treatment should consist of urethral catheterization for 1 to 2 weeks, followed by repeat voiding cystourethrogram. If the patent urachus still persists, one should proceed to surgical correction. C1 Tripler Army Med Ctr, Dept Urol, Honolulu, HI 96859 USA. RP Sutherland, RS (reprint author), Tripler Army Med Ctr, Dept Urol MCHK DSU, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM ronald.sutherland@amedd.army.mil NR 7 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD DEC PY 2005 VL 66 IS 6 BP 13207 EP 13209 DI 10.1016/j.urology.2005.06.121 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 995UR UT WOS:000234130200047 ER PT J AU Taft, SC Miller, MK Wright, SM AF Taft, SC Miller, MK Wright, SM TI Distribution of Borreliae among ticks collected from eastern states SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Borrelia burgdorferi; Borrelia lonestari; ticks; Lyme disease ID LYME-DISEASE SPIROCHETE; NORTHEASTERN UNITED-STATES; AMBLYOMMA-AMERICANUM ACARI; IXODES-SCAPULARIS; PUTATIVE AGENT; LONESTARI DNA; RASH ILLNESS; BURGDORFERI; IXODIDAE; VECTOR AB Lyme disease is the most commonly reported vector-borne disease in the United States and is transmitted by Borrelia burgdorferi-infected Ixodes species. The disease is typically characterized by an erythema migrans (EM) rash at the site of tick feeding. EM rashes have also been associated with feeding by Amblyomma americanum ticks despite evidence suggesting that they are incompetent vectors for Lyme disease. In 1996, a Borrelia organism only recently cultivated in the laboratory was described in A. americanum ticks and designated B. lonestari. This Borrelia is believed to be the etiologic agent of a novel Lyme-like disease, southern tick associated rash illness (STARI). This study examined ticks collected from eight eastern states to evaluate the epidemiology of B. lonestari, B. burgdorferi, and their tick hosts. Three hundred individual or small pool samples were evaluated from tick genera that included Amblyomma, Ixodes, and Dermacentor. DNA was extracted following tick homogenization and the polymerase chain reaction (PCR) was performed using primers derived from the flagellin gene that amplify sequences from both B. burgdorferi and B. lonestari. Species specific digoxigenin labeled probes were designed and used to differentiate between B. burgdorferi and B. lonestari. Borrelia DNA was detected in approximately 10% of the A. americanum and I. scapularis tick samples, but none was present in any of the Dermacentor samples tested. Positive samples were detected in ticks collected from Kentucky, Maryland, Massachusetts, New Jersey, New York, and Virginia. This is the first known report of B. lonestari from Massachusetts and New York and the first detection in I. scapularis. This suggests that B. lonestari and its putative association with STARI may be more widespread than previously thought. C1 Middle Tennessee State Univ, Dept Biol, Murfreesboro, TN 37132 USA. Univ Cincinnati, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH USA. USA, Ctr Hlth Promot & Prevent Med, Ft George G Meade, MD USA. RP Wright, SM (reprint author), Middle Tennessee State Univ, Dept Biol, Box 60, Murfreesboro, TN 37132 USA. EM smwright@mtsu.edu NR 27 TC 16 Z9 18 U1 0 U2 10 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD WIN PY 2005 VL 5 IS 4 BP 383 EP 389 DI 10.1089/vbz.2005.5.383 PG 7 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 004UP UT WOS:000234778200009 PM 16417434 ER PT J AU Butkus, MA Talbot, M Labare, MP AF Butkus, MA Talbot, M Labare, MP TI Feasibility of the silver-UV process for drinking water disinfection SO WATER RESEARCH LA English DT Article DE disinfection; silver; ultraviolet radiation; MS-2; silver-UV ID INACTIVATION; CRYPTOSPORIDIUM; BIOAVAILABILITY; EQUILIBRIA; RADIATION AB A synergistic effect between cationic silver and UV radiation (silver-UV disinfection) has been observed that can appreciably enhance inactivation of viruses. The purpose of this work was to assess the feasibility of this technique for drinking water disinfection and evaluate the effects of selected impurities, found in fresh water, and common parameters on inactivation of the coliphage MS-2 with the silver-UV process. Turbidity (kaolin), calcium hardness, carbonate alkalinity, and pH did not significantly degrade inactivation. Inactivation was reduced in the presence of chloride, at concentrations greater than 30 mg/L, and in water samples with UV-254 absorbance values greater than ca. 0.1 cm(-1). Inactivation of MS-2 with silver-UV disinfection was also reduced at high phosphate concentrations (above ca. 5mM). Silver-UV inactivation of MS-2 increased with increases in temperature between 10 and 20 degrees C. Silver-UV inactivation of MS-2 was increased by greater than I-log over UV alone, in two untreated fresh water sources, which indicates that silver-UV may be a viable treatment technology. An assessment of operation and management costs suggests that an increase in inactivation of MS-2 with silver-UV disinfection could be economically beneficial. Published by Elsevier Ltd. C1 US Mil Acad, Environm Engn Program, Dept Geog & Environm Engn, West Point, NY 10996 USA. US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Butkus, MA (reprint author), US Mil Acad, Environm Engn Program, Dept Geog & Environm Engn, West Point, NY 10996 USA. EM Michael.Butkus@usma.edu NR 20 TC 13 Z9 16 U1 1 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD DEC PY 2005 VL 39 IS 20 BP 4925 EP 4932 DI 10.1016/j.watres.2005.09.037 PG 8 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 000EB UT WOS:000234442600008 PM 16307773 ER PT J AU Oh, SY Chiu, PC Kim, BJ Cha, DK AF Oh, SY Chiu, PC Kim, BJ Cha, DK TI Zero-valent iron pretreatment for enhancing the biodegradability of RDX SO WATER RESEARCH LA English DT Article DE RDX; zero-valent iron; biodegradability; wastewater treatment ID HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; WASTE-WATER; ELECTROCHEMICAL REDUCTION; ELEMENTAL IRON; PERFORMANCE; OXIDATION; TNT AB Hexahydro-1,3,5-trinitro-1,3,5-triazine (CH6N3(NO2)(3), royal demolition explosive or RDX) is a common nitramine explosive and one of the major constituents in wastewaters from ammunitions plants. The objective of this study is to investigate zero-valent iron (Fe(0)) pretreatment for enhancing the biodegradability of recalcitrant RDX. It was hypothesized that iron pretreatment can reductively transform RDX to products that are more amenable to biological treatment processes such as activated sludge. Results of batch and column experiments showed rapid and complete removal of RDX by Fe(0) regardless of the buffering capacity. Formaldehyde (HCHO), a major reduction product of RDX, was readily biodegraded by a mixed culture. Respirometric data indicate that iron-treated RDX solution exerted substantially higher biochemical oxygen demand (BOD) than untreated RDX solution. We propose that an integrated iron reduction-activated sludge process may be a feasible option for treating RDX-laden wastewater. Published by Elsevier Ltd. C1 Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. USA, Engn Res & Dev Ctr, Champaign, IL 61826 USA. RP Cha, DK (reprint author), Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. EM quartzoh@ce.udel.edu; pei@ce.udel.edu; b-kim@cecer.army.mil; cha@ce.udel.edu NR 25 TC 36 Z9 47 U1 2 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD DEC PY 2005 VL 39 IS 20 BP 5027 EP 5032 DI 10.1016/j.watres.2005.10.004 PG 6 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 000EB UT WOS:000234442600018 PM 16290903 ER PT J AU Caine-Bish, N Potkanowicz, ES Otterstetter, R Marcinkiewicz, J Kamimori, G Glickman, E AF Caine-Bish, N Potkanowicz, ES Otterstetter, R Marcinkiewicz, J Kamimori, G Glickman, E TI The effect of cold exposure on the hormonal and metabolic responses to sleep deprivation SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article DE cold exposure; sleep deprivation; hormonal response; thermoregulation ID THYROID-HORMONE; THERMOREGULATORY RESPONSES; PHYSIOLOGICAL-RESPONSES; MEN; CATECHOLAMINE; TEMPERATURE; PERFORMANCE; THYROTROPIN; EXCRETION; CORTISOL AB Objective.-The purpose of this study was to determine the effect of 12 degrees C cold exposure for 180-minutes on the hormonal responses of sleep-deprived individuals. Methods.-Participants underwent 2 cold-air trials: 1 after a normal night of sleep (ie, 6-8 hours) and I after 33 hours of sleep deprivation (SDEP). A venous blood sample was taken at baseline and then at 90-and 180-minute cold-exposure time points. Repeated- measures analysis of variance was used to determine significance between a normal night of sleep and SDEP for norepinephrine, epinephrine, cortisol, insulin, thyroid hormones triiodothyronine and thyroxine, glucose, and non-esterified fatty acids. Results.-There was no significant main effect for time, trial, or interaction for insulin, thyroid hormones, epinephrine, cortisol, and glucose (P <= .05). A significant main effect for time for norepinephrine and non-esterified fatty acids was demonstrated (P < .001). Discussion.-The lack of significant differences in the hormonal and metabolic responses to cold exposure combined with SDEP may have been because of an ability of the individual to continue to respond despite the environmental stressor or the physiological effect elicited from cold exposure, thereby possibly masking physiological responses of SDEP. Conclusions.-On the basis of these data, SDEP combined with protracted cold exposure apparently was Dot a great enough stressor to cause a differential response in the hormonal and metabolic parameters. C1 Kent State Univ, Sch Family & Consumer Studies, Kent, OH 44242 USA. Kent State Univ, Dept Biol Sci, Kent, OH 44242 USA. Kent State Univ, Sch Exercise Leisure & Sport, Kent, OH 44242 USA. NE Illinois Univ, Dept Hlth Phys Educ Recreat & Athlet, Chicago, IL 60625 USA. Univ Akron, Dept Sport Sci & Wellness, Akron, OH 44325 USA. Walter Reed Army Inst Res, Dept Neurobiol & Behav, Silver Spring, MD USA. RP Caine-Bish, N (reprint author), Kent State Univ, Sch Family & Consumer Studies, 100 Nixson Hall, Kent, OH 44242 USA. EM ncaine@kent.edu NR 35 TC 2 Z9 2 U1 4 U2 10 PU ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD WIN PY 2005 VL 16 IS 4 BP 177 EP 184 DI 10.1580/PR37-04.1 PG 8 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 991SZ UT WOS:000233835400001 PM 16366197 ER PT J AU Brandt, HE AF Brandt, Howard E. TI Finslerian quantum field theory SO NONLINEAR ANALYSIS-THEORY METHODS & APPLICATIONS LA English DT Article DE Finslerian fields; Maximal proper acceleration; Quantum field theory; Vacuum energy density; Cosmological constant; Dark energy AB Finsler geometry suggests a generalization of the Riemannian structure of spacetime to include dependence of the spacetime metric and associated invariant tensor fields on the four-velocity coordinates as well as the spacetime coordinates of the observer. It is useful to consider the tangent bundle of spacetime with spacetime in the base manifold and four-velocity space in the fiber. A physical basis for the differential geometric structure of the spacetime tangent bundle is provided by the universal upper limit on proper acceleration relative to the vacuum. It is then natural to consider a quantum field having a vanishing eigenvalue when acted on by the Laplace-Beltrami operator of the spacetime tangent bundle. On this basis a quantum field theory can be constructed having a built-in intrinsic regularization at the Planck scale, and finite vacuum energy density. This may provide insight concerning the cosmological constant and the accelerating universe. Published by Elsevier Ltd. C1 USA, Res Lab, AMSRL SE SE, Adelphi, MD 20783 USA. RP Brandt, HE (reprint author), USA, Res Lab, AMSRL SE SE, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM hbrandt@arl.army.mil NR 31 TC 1 Z9 1 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0362-546X J9 NONLINEAR ANAL-THEOR JI Nonlinear Anal.-Theory Methods Appl. PD NOV 30 PY 2005 VL 63 IS 5-7 BP E119 EP E130 DI 10.1016/j.na.2005.02.085 PG 12 WC Mathematics, Applied; Mathematics SC Mathematics GA V20NX UT WOS:000208147800012 ER PT J AU Shin, SB Yoo, MH Jeong, JB Kim, YM Chung, JK Do Huh, M Komisar, JL Do Jeong, H AF Shin, SB Yoo, MH Jeong, JB Kim, YM Chung, JK Do Huh, M Komisar, JL Do Jeong, H TI Molecular cloning of the gyrA gene and characterization of its mutation in clinical isolates of quinolone-resistant Edwardsiella tarda SO DISEASES OF AQUATIC ORGANISMS LA English DT Article DE Edwardsiella tarda; gyrA; quinolone; resistance; mutation ID DNA GYRASE; NUCLEOTIDE-SEQUENCE; ESCHERICHIA-COLI; TOPOISOMERASE-IV; FLUOROQUINOLONE RESISTANCE; ENTEROCOCCUS-FAECALIS; DETERMINING REGIONS; REPLICATION; MUTANTS; SUBUNIT AB Knowing the entire sequence of the gene encoding the DNA gyrase Subunit A (gyrA) of Edwardsiella tarda could be very useful for confirming the role of gyrA in quinolone resistance. Degenerate primers for the amplification of gyrA were designed from consensus nucleotide sequences of gyrA from 9 different Gram-negative bacteria, including Escherichia coli. With these primers, DNA segments of the predicted size were amplified from the genomic DNA of E. tarda and then the flanking sequences were determined by cassette ligation-mediated polymerase chain reaction. The nucleotide sequence of gyrA was highly homologous to those of other bacterial species, in both the whole open-reading frame and the quinolone-resistance-determining region (QRDR). The 2637-bp gyrA gene encodes a protein of 878 amino acids, preceded by a putative promoter, ribosome binding site and inverted repeated sequences for cruciform structures of DNA. However, the nucleotide sequence of the flanking region did not show any homologies with those of other bacterial DNA gyrase Subunit B genes (gyrB) and suggested the gyrase genes, gyrA and gyrB, are non-continuous on the chromosome of E. tarda, All of the 12 quinolone-resistant isolates examined have an alteration within the QRDR, Ser(83)-> Arg, suggesting that, in E. tarda, resistance to quinolones is primarily related to alterations in gyrA. Transformation with the full sequence of E. tarda gyrA bearing the Ser(83)-> Arg mutation was able to complement the sequence of the gyrA temperature-sensitive mutation in the E. coli KNK453 strain and to induce increased resistance to quinolone antibiotics at 42 degrees C. C1 Pukyong Natl Univ, Dept Aquat Life Med, Pusan 608737, South Korea. Yonsei Univ, Dept Biol, Seoul 120749, South Korea. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. RP Do Jeong, H (reprint author), Pukyong Natl Univ, Dept Aquat Life Med, 599-1 Dae Yeon Dong, Pusan 608737, South Korea. EM jeonghd@pknu.ac.kr NR 38 TC 3 Z9 3 U1 0 U2 3 PU INTER-RESEARCH PI OLDENDORF LUHE PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY SN 0177-5103 J9 DIS AQUAT ORGAN JI Dis. Aquat. Org. PD NOV 28 PY 2005 VL 67 IS 3 BP 259 EP 266 DI 10.3354/dao067259 PG 8 WC Fisheries; Veterinary Sciences SC Fisheries; Veterinary Sciences GA 008EG UT WOS:000235022400010 PM 16408842 ER PT J AU Thellen, C Orroth, C Froio, D Ziegler, D Lucciarini, J Farrell, R D'Souza, NA Ratto, JA AF Thellen, C Orroth, C Froio, D Ziegler, D Lucciarini, J Farrell, R D'Souza, NA Ratto, JA TI Influence of montmorillonite layered silicate on plasticized poly(L-lactide) blown films SO POLYMER LA English DT Article DE polylactide; montmorillonite; nanocomposites; biodegradation; barrier properties ID CRYSTALLIZATION BEHAVIOR; ACID) NANOCOMPOSITES; POLY(LACTIC ACID); BIODEGRADABILITY; MORPHOLOGY; RHEOLOGY AB Plasticized poly(L-lactide) (PLA) montmorillonite layered silicate (MLS) nanocomposites were compounded and blown-film processed using a co-rotating twin screw extruder. PLA was mixed with 10 wt% acetyltriethyl citrate ester plasticizer and 5 wt% of an organically modified montmorillonite at various screw speeds. Wide-angle X-ray diffraction (WAXD) and transmission electron microscopy (TEM) determined that the compounded pellets and the blown film PLA/MLS nanocomposites were intercalated. The effect of processing screw speeds on the barrier, thermal, mechanical, and biodegradation properties of the nanocomposites were analyzed and compared to the neat polymer. Nanocomposite films show a 48% improvement in oxygen barrier and a 50% improvement in water vapor barrier in comparison to the neat PLA. The thermogravimetric analysis (TGA) showed an overall 9 degrees C increase in the decomposition temperature for all of the nanocomposites. Differential scanning calorimetry (DSC) has determined that the glass transition, cold crystallization and melting point temperatures were not significantly influenced by the presence of MLS. Mechanical properties of the nanocomposites showed that the Young's modulus increased by 20% and the ultimate elongation of the nanocomposites were not sacrificed in comparison to the neat samples. Biodegradation rates in soil were slightly greater for the PLA/MLS nanocomposite than the pure PLA. However, none of the PLA pure and nanocomposites achieved significant biodegradation levels after 180 days. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Natick Soldier Ctr, Nanomat Sci Team, Natick, MA 01760 USA. Adv Proc Team, Natick, MA 01760 USA. Univ Saskatchewan, Dept Soil Sci, Saskatoon, SK S7N 5A8, Canada. Univ N Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA. RP Ratto, JA (reprint author), USA, Natick Soldier Ctr, Nanomat Sci Team, Kansas St, Natick, MA 01760 USA. EM joann.ratto@natick.army.mil NR 46 TC 136 Z9 147 U1 2 U2 49 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD NOV 28 PY 2005 VL 46 IS 25 BP 11716 EP 11727 DI 10.1016/j.polymer.2005.09.057 PG 12 WC Polymer Science SC Polymer Science GA 990HL UT WOS:000233733700063 ER PT J AU Abbott, KC Kimmel, PL Dharnidharka, V Oglesby, RJ Agodoa, LY Caillard, S AF Abbott, KC Kimmel, PL Dharnidharka, V Oglesby, RJ Agodoa, LY Caillard, S TI New-onset gout after kidney transplantation: Incidence, risk factors and implications SO TRANSPLANTATION LA English DT Article DE new-onset gout; cyclosporine; creatinine; glomerular filtration rate; age; body mass index; obesity; medicare claim; kidney transplant; end stage kidney disease; USRDS ID CYCLOSPORINE-INDUCED HYPERURICEMIA; CHRONIC HEART-FAILURE; URIC-ACID; CARDIOVASCULAR-DISEASE; RENAL-DISEASE; HYPERTENSION; RECIPIENTS; EPIDEMIOLOGY; TACROLIMUS; SURVIVAL AB Background. Although cyclosporine use has been associated with an increased risk of new-onset gout after renal transplantation, the incidence and risk factors for new-onset gout have not been reported in the era of modern immunosuppression. Methods. We conducted a retrospective cohort study of Medicare primary renal transplant patients reported in the United States Renal Data System (USRDS), using Medicare claims data to determine the incidence of new-onset gout. Cox regression analysis was used to calculate adjusted hazard ratios (AHR) for cyclosporine (including separate analysis of Neoral) compared directly with tacrolimus, for the risk of new-onset gout, adjusted for baseline demographic factors and posttransplant renal function. Results. The cumulative incidence of new-onset gout was 7.6% at 3 years posttransplant. The following factors were independently associated with an increased risk of new-onset gout: use of Neoral (vs. tacrolimus, AHR 1.25, 95% CI 1.07-1.47) at discharge, recipient male sex (AHR 1.44, 95% CI 1.25-1.67), older age, higher body mass index, and more recent year of transplant. No other immunosuppressive medications were associated with new-onset gout. Diabetes was associated with a significantly lower risk of new-onset gout. The development of new-onset gout was independently associated with decreased patient survival (AHR 1.26, 95% CI 1.08-1.47) as well as death-censored graft survival. Conclusions. Cyclosporine is an independent risk factor for new-onset gout after transplantation. The incidence of new-onset gout appears to be increasing even while the use of cyclosporine is decreasing, and the development of new-onset gout was an independent predictor for death and graft loss in this population. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. George Washington Univ, Med Ctr, Dept Med, Washington, DC 20037 USA. Univ Florida, Div Renal, Gainesville, FL USA. Walter Reed Army Med Ctr, Rheumatol Serv, Washington, DC 20307 USA. NIDDKD, NIH, Bethesda, MD USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM kevin.abbott@na.amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 41 TC 34 Z9 41 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD NOV 27 PY 2005 VL 80 IS 10 BP 1383 EP 1391 DI 10.1097/01.tp.0000188722.84775.af PG 9 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 994YH UT WOS:000234066600005 PM 16340779 ER PT J AU Marrone, PA Cantwell, SD Dalton, DW AF Marrone, PA Cantwell, SD Dalton, DW TI SCWO system designs for waste treatment: Application to chemical weapons destruction SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID SUPERCRITICAL WATER OXIDATION; SALT PRECIPITATION; SCALE CONTROL; PART AB Supercritical water oxidation (SCWO) is a rapidly maturing technology for organic waste destruction, as witnessed by the increased number of full-scale plants being constructed around the world for many diverse feeds. The U.S. Army is one organization that has committed to installing SCWO as part of its overall demilitarization process for chemical weapons stored at the Blue Grass Chemical Activity in Richmond, KY. This choice of technology was based on extensive testing conducted by the Army on two different reactor designs: solid wall and transpiring wall reactors. This paper presents data and results from this test program conducted for both SCWO reactor system designs. C1 A Geo Ctr Inc Co, FOCIS Associates Inc, Newton, MA 02459 USA. USA, Assembled Chem Weapons Alternat, Aberdeen Proving Ground, MD 21010 USA. RP Marrone, PA (reprint author), A Geo Ctr Inc Co, FOCIS Associates Inc, 7 Wells Ave, Newton, MA 02459 USA. EM pmarrone@geo-centers.com NR 14 TC 31 Z9 32 U1 2 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD NOV 23 PY 2005 VL 44 IS 24 BP 9030 EP 9039 DI 10.1021/ie0506670 PG 10 WC Engineering, Chemical SC Engineering GA 986ZR UT WOS:000233488700010 ER PT J AU Mulligan, CP Gall, D AF Mulligan, CP Gall, D TI CrN-Ag self-lubricating hard coatings SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 32nd International Conference on Metallurgical Coatings and Thin Film CY MAY 02-06, 2005 CL San Diego, CA SP AVS Sci & Technol Soc, Adv Surface Engn Div DE solid lubrication; chromium nitride; silver; segregation; wear ID HIGH-TEMPERATURE OXIDATION; THERMAL-STABILITY; MULTILAYER COATINGS; FILMS; PERFORMANCE; DEPOSITION; RESISTANCE; COMPOSITE; GROWTH; TIN AB CrN - Ag composite films, 2.5 - 4 mu m thick, were deposited by reactive magnetron sputtering on Si and stainless steel substrates in a 0.4 Pa pure nitrogen atmosphere at 500 degrees C. The layer composition was controlled by the relative power to 7.5-cm-diameter Ag and Cr targets to be 0, 3, 12, and 22 at.% Ag. The layers exhibit a dense columnar microstructure where the Ag is homogeneously distributed in the CrN matrix. The coatings were vacuum annealed for t(a)=5-60 min at temperatures ranging from T(a)=600-700 degrees C, to study the Ag-lubricant transport to the surface. Ag surface segregation during annealing is negligible for layers with 3 at.% Ag content. However, Ag diffuses to the surface of layers with >= 12 at.% Ag and forms particles with diameters ranging, as a function of T(a) and ta, from 50 to 1100 nm. Statistical analyses provide average particle sizes of 110 and 375 nm, and surface particle densities of 2 x 10(7) and 1.7 x 10(6) mm(-2), for the 12 and 22% Ag samples, respectively. The Ag diffusive transport occurs 2-3 times faster for the 22% than for the 12% sample. We attribute the increase in Ag transport as a function of the total Ag concentration to a network of pores that form during deposition due to Ag segregation into nanometer-size pockets. The pores grow in width and connectivity as the total Ag concentration is increased, leading to a faster Ag transport at elevated Ag concentrations. Room-temperature micro-scratch tests show that the average friction coefficients and wear track depths monotonically decrease, by 27 and 56%, respectively, when the Ag concentration is increased from 0 to 22 at.%. (c) 2005 Elsevier B.V All rights reserved. C1 USA, Armament Res & Dev Ctr, Benet Labs, Watervliet, NY 12189 USA. Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. RP Mulligan, CP (reprint author), USA, Armament Res & Dev Ctr, Benet Labs, Watervliet, NY 12189 USA. EM mulligan@pica.army.mil RI Gall, Daniel/B-1060-2008 OI Gall, Daniel/0000-0002-5762-9307 NR 23 TC 93 Z9 97 U1 8 U2 40 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD NOV 21 PY 2005 VL 200 IS 5-6 BP 1495 EP 1500 DI 10.1016/j.surfcoat.2005.08.063 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 995JM UT WOS:000234096600051 ER PT J AU Krapels, K Driggers, RG Teaney, B AF Krapels, K Driggers, RG Teaney, B TI Target-acquisition performance in undersampled infrared imagers: static imagery to motion video SO APPLIED OPTICS LA English DT Article ID SYSTEM PERFORMANCE; TOD; MODEL AB In this research we show that the target-acquisition performance of an undersampled imager improves with sensor or target motion. We provide an experiment designed to evaluate the improvement in observer performance as a function of target motion rate in the video. We created the target motion by mounting a thermal imager on a precision two-axis gimbal and varying the sensor motion rate from 0.25 to 1 instantaneous field of view per frame. A midwave thermal imager was used to permit short integration times and remove the effects of motion blur. It is shown that the human visual system performs a superresolution reconstruction that mitigates some aliasing and provides a higher (than static imagery) effective resolution. This process appears to be relatively independent of motion velocity. The results suggest that the benefits of superresolution reconstruction techniques as applied to imaging systems with motion may be limited. (c) 2005 Optical Society of America. C1 Off Naval Res, Arlington, VA 22217 USA. USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Krapels, K (reprint author), Off Naval Res, 800 N Quincy St, Arlington, VA 22217 USA. EM rdrigger@nvl.army.mil NR 14 TC 9 Z9 9 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 20 PY 2005 VL 44 IS 33 BP 7055 EP 7061 DI 10.1364/AO.44.007055 PG 7 WC Optics SC Optics GA 984ZD UT WOS:000233345000006 PM 16318174 ER PT J AU Ackers, M Alexander, SB Allen, M Bakari, M Barsdorf, N Barth-Jones, D Birx, D Cunningham, CK DeCock, K Francis, D Fuchs, J Hemelaar, J Ireland, J Kapoor, S Karamov, E Klein, M Levendal, E Lie, R Macklin, R Mathieson, B Mathur, R Mukengetshibaka, L Nanvubya, A Nakwagala, F Nixon, S Pantaleo, G Pitisuttithum, P Rogers, AS dos Santos, VGV Sheets, R Safrit, J Smit, T Thorpe, P Verlinde, C Villafana, T Warren, M Xu, J Mhalu, F Thior, I Amin, A Bouesseau, MC Chang, ML Henri, M Kieny, MP Labelle, S Malonza, I Obermeyer, CM Osmanov, S Otani, J Pagliusiuhe, S Schmid, G Sigurdson, J Collins, C Hankins, C Thiam, MB AF Ackers, M Alexander, SB Allen, M Bakari, M Barsdorf, N Barth-Jones, D Birx, D Cunningham, CK DeCock, K Francis, D Fuchs, J Hemelaar, J Ireland, J Kapoor, S Karamov, E Klein, M Levendal, E Lie, R Macklin, R Mathieson, B Mathur, R Mukengetshibaka, L Nanvubya, A Nakwagala, F Nixon, S Pantaleo, G Pitisuttithum, P Rogers, AS dos Santos, VGV Sheets, R Safrit, J Smit, T Thorpe, P Verlinde, C Villafana, T Warren, M Xu, J Mhalu, F Thior, I Amin, A Bouesseau, MC Chang, ML Henri, M Kieny, MP Labelle, S Malonza, I Obermeyer, CM Osmanov, S Otani, J Pagliusiuhe, S Schmid, G Sigurdson, J Collins, C Hankins, C Thiam, MB CA WHO-UNAIDS Expert Grp TI Gender, age, and ethnicity in HIV vaccine-related research and clinical trials - Report from a WHO-UNAIDS consultation, 26-28 August 2004. Lausanne, Switzerland SO AIDS LA English DT Article DE HIV vaccines; clinical trials; vaccine efficacy; gender; age; ethnicity; ethics; regulatory aspects; community preparedness ID COST-EFFECTIVENESS; HERD-IMMUNITY; INFECTION; PROGRAMS; EFFICACY; ESCAPE; IMPACT AB This report summarizes the presentations and recommendations from a consultation held in Lausanne, Switzerland (26-28 August 2004) organized by the joint World Health Organization (WHO) - United Nations Programme on HlV/AIDS (UNAIDS) HIV Vaccine Initiative. The consultation discussed issues related to gender, ethnicity, and age in HIV vaccine research and clinical trial recruitment. A special focus of the meeting was the participation of women and adolescents in clinical trials. Also discussed were the experiences and lessons from various research programs, trials, and studies in different countries. Implementing the recommendations from this meeting will require prioritization and active participation from the research community, funders of research, local and national governments, non-governmental organizations, and industry, as well as the individuals and communities participating in clinical trials. This report contains the collective views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the WHO. The contribution of the co-chairs (R. Macklin and F. Mhalu) and the rapporteurs (H. Lasher, M. Klein, M. Ackers, N. Barsdorf, A. Smith Rogers, E. Levendal, T. Villafana and M. Warren) during the consultation and in the preparation of this report is much appreciated. S. Labelle and J. Otani are also acknowledged and thanked for their efficient assistance in the preparation of the consultation and the report. C1 Ctr Dis Control & Prevent, Atlanta, GA USA. HIV Vaccine Trials Network, Washington, DC USA. NIH, Bethesda, MD 20892 USA. Muhimbili Univ, Coll Hlth Sci, Dar Es Salaam, Tanzania. Univ KwaZulu Natal, Sch Psychol, Scottsville, South Africa. Ctr Healthcare Effectiveness Res, Detroit, MI USA. Dept Internal Med, Detroit, MI USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Duke Univ, Med Ctr, Durham, NC 27706 USA. Ctr Dis Control & Prevent, Nairobi, Kenya. San Francisco Dept Publ Hlth, San Francisco, CA USA. Univ Oxford, Sch Med, Oxford, England. Elizabeth Glazer Pediat AIDS Fdn, Washington, DC USA. Int AIDS Vaccine Initiat, New York, NY USA. Minist Hlth, Moscow, Russia. Canadian Network Vaccines & Immunotherapeut, Quebec City, PQ, Canada. S African AIDS Vaccine Initiat, Tygerberg, South Africa. Univ Bergen, Bergen, Norway. Albert Einstein Coll Med, New York, NY USA. Indian Council Med Res, New Delhi, India. Canadian Int Dev Agcy, Quebec City, PQ, Canada. Uganda Virus Res Inst, Entebbe, Uganda. Canadian HIV AIDS Legal Network, Toronto, ON, Canada. CHU Vaudois, CH-1011 Lausanne, Switzerland. Mahidol Univ, Bangkok 10700, Thailand. Ctr Referencia Ensaios Clin HIV AIDS, Rio De Janeiro, Brazil. S African AIDS Vaccine Initiat, Tygerberg, South Africa. Int AIDS Vaccine Initiat, New York, NY USA. Botswana Harvard AIDS Inst, Gaborone, Botswana. AIDS Vaccine Advocacy Coalit, New York, NY USA. Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. Muhmbili Univ, Coll Hlth Sci, Dar Es Salaam, Tanzania. RP Osmanov, S (reprint author), WHO, UNAIDS HIV Vaccine Initiat, Geneva, Switzerland. EM osmanovs@who.int RI Pantaleo, Giuseppe/K-6163-2016 NR 15 TC 4 Z9 4 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD NOV 18 PY 2005 VL 19 IS 17 BP W7 EP W28 PG 22 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 986IV UT WOS:000233444200025 ER PT J AU Bowman, PD Sondeen, JL Zhao, B Coppes, VG Nelson, JJ Dubick, MA Vaughan, GM AF Bowman, PD Sondeen, JL Zhao, B Coppes, VG Nelson, JJ Dubick, MA Vaughan, GM TI A temporal study of gene expression in rat lung following fixed-volume hemorrhage SO PHYSIOLOGICAL GENOMICS LA English DT Article DE gene expression profiling; ischemic lung injury ID REDUCES NEUTROPHIL MARGINATION; CYTOKINE-GENERATING ORGAN; CELL DYSFUNCTION OCCURS; SHOCK MESENTERIC LYMPH; L SELECTIN EXPRESSION; NF-KAPPA-B; MONONUCLEAR-CELLS; P-SELECTIN; RESUSCITATION; INJURY AB A temporal study of gene expression in rat lung following fixed-volume hemorrhage. Physiol Genomics 23: 275-286, 2005. First published September 13, 2005; doi: 10.1152/physiolgenomics. 00075.2005.-Previous studies have indicated that hemorrhage may predispose the lung to respiratory distress syndrome. Gene expression profiling with oligonucleotide microarrays was used to evaluate the genetic responses of the lung to hemorrhage. Conscious rats, chronically instrumented with a catheter and telemetry device to record blood pressure, heart rate, and temperature, had 40% of their estimated blood volume removed at a rate of 1 ml/ min over 7-10 min. Groups of three or more rats were euthanized at 1, 3, 6, 16, 24, 48, or 72 h following hemorrhage. Two additional groups were unmanipulated controls and instrumented animals with sham hemorrhage. Total RNA was isolated from lung, reverse-transcribed to cDNA, fluorescently labeled, and hybridized to oligonucleotide microarrays probing 5,671 rat genes. After hemorrhage, statistically detectable alteration of expression was seen in similar to 0.8% of the genes at some time during the 72-h test period (vs. sham hemorrhage) as determined by false discovery rate statistics in the statistical analysis of microarrays program. A subset was confirmed by RT-PCR analysis. Hemorrhage influenced genes that regulate intracellular signaling and structure, growth factors, and hormonal receptors. There also appeared to be increased expression of genes that may mediate sequestration of neutrophils and mononuclear cells from the circulation. This hemorrhage model, although producing severe hemodynamic alterations, avoided mortality and histological evidence of lung damage, a feature intended to help ensure reliable evaluation of gene expression. These results indicate that gene expression profiling with microarrays provides a new tool for exploring the response of a tissue to systemic blood loss. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Bowman, PD (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM phillip.bowman@amedd.army.mil NR 44 TC 2 Z9 2 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1094-8341 J9 PHYSIOL GENOMICS JI Physiol. Genomics PD NOV 17 PY 2005 VL 23 IS 3 BP 275 EP 286 DI 10.1152/physiolgenomics.000075.2005 PG 12 WC Cell Biology; Genetics & Heredity; Physiology SC Cell Biology; Genetics & Heredity; Physiology GA 995FN UT WOS:000234086300003 PM 16159910 ER PT J AU More, KF Buda, EM Sarmiento, D Kim, AS Golarz, SR Stojadinovic, A Reid, TJ AF More, KF Buda, EM Sarmiento, D Kim, AS Golarz, SR Stojadinovic, A Reid, TJ TI Spontaneous rupture of spleen during chemotherapy in aggressive NHL. SO BLOOD LA English DT Meeting Abstract CT 47th Annual Meeting of the American-Society-of-Hematology CY DEC 10-13, 2005 CL Atlanta, GA SP Amer Soc Hematol C1 Walter Reed Army Med Ctr, Div Hematol & Oncol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2005 VL 106 IS 11 MA 4748 BP 267B EP 267B PN 2 PG 1 WC Hematology SC Hematology GA 986CG UT WOS:000233426101450 ER PT J AU Lever, JH Taylor, S Perovich, L Bjella, K Packer, B AF Lever, JH Taylor, S Perovich, L Bjella, K Packer, B TI Dissolution of composition B detonation residuals SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID 2,4,6-TRINITROTOLUENE TNT; SOLUBILITY; WATER; RATES; RDX AB Composition B (Comp B) detonation residuals pose environmental concern to the U. S. Army because hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a constituent, has contaminated groundwater near training ranges. To mimic their dissolution on surface soils, we dripped water at 0.51 mL/h onto individual Comp B particles (0.1-2.0 mg) collected from the detonation of 81-mm mortars. Analyses of the effluent indicate that the RDX and 2,4,6-trinitrotoluene (TNT) in Comp B do not dissolve independently. Rather, the relatively slow dissolution of RDX controls dissolution of the particle as a whole by limiting the exposed area of TNT. Two dissolution models, a published steady-flow model and a drop-impingement model developed here, provide good agreement with the data using RDX parameters for time scaling. They predict dissolution times of 6-600 rainfall days for 0.01-100 mg Comp B particles exposed to 0.55 cm/h rainfall rate. These models should bracket the flow regimes for dissolution of detonation residuals on soils, but they require additional data to validate them across the range of particle sizes and rainfall rates of interest. C1 USA, Ctr Res Dev & Engn, Hanover, NH 03755 USA. USA, Ctr Environm, Aberdeen Proving Ground, MD 21010 USA. RP Lever, JH (reprint author), USA, Ctr Res Dev & Engn, 72 Lyme Rd, Hanover, NH 03755 USA. EM james.h.lever@erdc.uscae.army.mil NR 23 TC 24 Z9 24 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 15 PY 2005 VL 39 IS 22 BP 8803 EP 8811 DI 10.1021/es050511r PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 984IS UT WOS:000233297100039 PM 16323780 ER PT J AU Cannard, K AF Cannard, K TI Nerve agents: The ABCs of management SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Meeting Abstract CT 18th World Congress of Neurology CY NOV 05-11, 2005 CL Sydney, AUSTRALIA C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD NOV 15 PY 2005 VL 238 SU 1 BP S8 EP S9 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 009CF UT WOS:000235088000033 ER PT J AU Cannard, KR Tsao, JW Labutta, RJ Riechers, RG Moquin, RR Rosner, MK Kuklo, TR Spencer, NA Ling, GSF AF Cannard, KR Tsao, JW Labutta, RJ Riechers, RG Moquin, RR Rosner, MK Kuklo, TR Spencer, NA Ling, GSF TI Pilot study using botulinum toxin A pre-treatment of lumbar spine muscles for relieving post-operative pain SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Meeting Abstract CT 18th World Congress of Neurology CY NOV 05-11, 2005 CL Sydney, AUSTRALIA C1 Def Spinal Cord & Column Injury Program, Washington, DC USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD NOV 15 PY 2005 VL 238 SU 1 BP S502 EP S502 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 009CF UT WOS:000235088004326 ER PT J AU Russo, M Sing, H Kendall, A Johnson, D Santiago, S Escolas, S Holland, D Thorne, D Hall, D Redmond, D AF Russo, M Sing, H Kendall, A Johnson, D Santiago, S Escolas, S Holland, D Thorne, D Hall, D Redmond, D TI Visual perceptual impairments with sleep deprivation parallel Balint's Syndrome visual neglect SO JOURNAL OF THE NEUROLOGICAL SCIENCES LA English DT Meeting Abstract CT 18th World Congress of Neurology CY NOV 05-11, 2005 CL Sydney, AUSTRALIA C1 Walter Reed Army Inst Res, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-510X J9 J NEUROL SCI JI J. Neurol. Sci. PD NOV 15 PY 2005 VL 238 SU 1 BP S47 EP S47 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 009CF UT WOS:000235088000186 ER PT J AU Fedotov, AB Konorov, SO Serebryannikov, EE Sidorov-Biryukov, DA Mitrokhin, VP Dukel'skii, KV Khokhlov, A Shevandin, VS Kondrat'ev, YN Scalora, M Zheltikov, AM AF Fedotov, AB Konorov, SO Serebryannikov, EE Sidorov-Biryukov, DA Mitrokhin, VP Dukel'skii, KV Khokhlov, A Shevandin, VS Kondrat'ev, YN Scalora, M Zheltikov, AM TI Assorted non-linear optics in microchannel waveguides of photonic-crystal fibers SO OPTICS COMMUNICATIONS LA English DT Article AB Unamplified 50-fs Ti:sapphire laser pulses are used to demonstrate physically different scenarios of non-linear-optical spectral transformations in the normal and anomalous dispersion regions in microchannel waveguides off the central core in photonic-crystal fibers. Signatures of polarization-dependent soliton self-frequency shift and dispersive-wave emission are shown to dominate the spectra of radiation transmitted through these waveguides in the regime where the pump wavelength initially falls within the range of normal dispersion, but lies close to the point of zero group-velocity dispersion. Form birefringence of microchannel waveguides allows polarization frequency switching of visible-range spectral components and results in a polarization sensitivity of supercontinuum generation. In the regime of anomalous dispersion, self-phase-modulation-induced phase matching is shown to result in modulation-instability-type four-wave mixing, leading to efficient generation of spectral sidebands at a typical interval of about 50 THz from the central frequency of the pump field. (c) 2005 Published by Elsevier B.V. C1 Moscow MV Lomonosov State Univ, Dept Phys, Ctr Int Laser, Moscow 119899, Russia. SI Vavilov State Opt Inst, St Petersburg 199034, Russia. USA, Aviat & Missile Command, Weapons Sci Directorate, Huntsville, AL 35898 USA. RP Zheltikov, AM (reprint author), Moscow MV Lomonosov State Univ, Dept Phys, Ctr Int Laser, Vorobevy Gory, Moscow 119899, Russia. EM zheitikov@phys.msu.ru RI Serebryannikov, Evgeny/M-2583-2014; Dukel'skii, Konstantin/N-1523-2014 OI Dukel'skii, Konstantin/0000-0002-1627-7499 NR 39 TC 10 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD NOV 15 PY 2005 VL 255 IS 4-6 BP 218 EP 224 DI 10.1016/j.optcom.2005.06.063 PG 7 WC Optics SC Optics GA 980FU UT WOS:000233000400006 ER PT J AU Deviren, V Acaroglu, E Lee, J Fujita, M Hu, S Lenke, LG Polly, D Kuklo, TR O'Brien, M Brumfield, D Puttlitz, CM AF Deviren, V Acaroglu, E Lee, J Fujita, M Hu, S Lenke, LG Polly, D Kuklo, TR O'Brien, M Brumfield, D Puttlitz, CM TI Pedicle screw fixation of the thoracic spine: An in vitro biomechanical study on different configurations SO SPINE LA English DT Article DE thoracic spine; biomechanics; pedicle screws; construct stiffness ID IDIOPATHIC SCOLIOSIS; TRANSPEDICULAR FIXATION; INTERNAL-FIXATION; SACRAL SPINE; LUMBAR; INSTRUMENTATION; PLACEMENT; STABILITY; FUSION; HOOKS AB Study Design. An in vitro biomechanical study of different pedicle screw configuration usage on the thoracic spine using a cadaveric model. Objectives. To investigate the degree of motion afforded different pedicle screw configurations in the thoracic spine using a cadaveric model with 2 different degrees of intrinsic stability. Summary of Background Data. Recently, thoracic pedicle screws have become an alternative to hook and wire fixation, and have gained popularity. Clinically, pedicle screw use has ranged from application to every segment, to skipping every other level. There exists no clear consensus as to which strategy is most appropriate. Methods. The load-displacement behavior of 6 different constructs was determined on 8 fresh frozen cadaver spine specimens (T4-T12). Each construct was evaluated on 2 destabilization models, including minimum destabilization (bilateral facetectomy) and maximum destabilization (facetectomy and annulotomy). Pure moments were applied, and the resultant range of motion for each scenario was determined. Results. Facetectomy did not significantly destabilize the thoracic spine. Annulotomy and facetectomy created gross instability that rendered testing of this destabilization model impossible. All constructs significantly reduced the range of motion compared to intact or facetectomized specimens (P <= 0.001). When different constructs were compared to each other, a pattern of continuously increasing stability emerged, with the "maximum" construct being the most stable and "minimum" configuration being the least, with varying degrees of statistical significance. Conclusions. Our results suggest that the most important factor for the acute postoperative stability of spinal fixation is the degree of preoperative or iatrogenic destabilization. The minimum amount of pedicle screws provides adequate stability when there is minimal destabilization of the spine. On the other hand, when anterior column release has been performed or instability exists before surgery, segmental pedicle screw fixation may be necessary to achieve adequate stability. C1 Univ Calif San Francisco, San Francisco Gen Hosp, Orthopaed Biomech Lab, San Francisco, CA 94110 USA. Washington Univ, Dept Orthopaed Surg, St Louis, MO 63130 USA. Univ Minnesota, Dept Orthopaed Surg, Minneapolis, MN 55455 USA. Walter Reed Army Med Ctr, Dept Orthopaed Surg, Washington, DC 20307 USA. Miami Childrens Hosp, Dept Orthopaed Surg, Miami, FL USA. Medtron Sofamor Danek, Thoracolumbar Div, Memphis, TN USA. RP Puttlitz, CM (reprint author), Univ Calif San Francisco, San Francisco Gen Hosp, Orthopaed Biomech Lab, 3A36,1001 Potrero Ave, San Francisco, CA 94110 USA. EM cputtlitz@orthosurg.ucsf.edu NR 39 TC 23 Z9 26 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0362-2436 J9 SPINE JI SPINE PD NOV 15 PY 2005 VL 30 IS 22 BP 2530 EP 2537 DI 10.1097/01.brs.0000186590.45675.ce PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 985PF UT WOS:000233389600009 PM 16284591 ER PT J AU Caillard, S Dharnidharka, V Agodoa, L Bohen, E Abbott, K AF Caillard, S Dharnidharka, V Agodoa, L Bohen, E Abbott, K TI Posttransplant lymphoproliferative disorders after renal transplantation in the United States in era of modern immunosuppression SO TRANSPLANTATION LA English DT Article DE kidney transplantation; posttransplant lymphoproliferative disorders; immunosuppression; United States Renal Data System ID BARR-VIRUS INFECTION; KIDNEY-TRANSPLANTATION; MYCOPHENOLATE-MOFETIL; GRAFT-SURVIVAL; ORGAN-TRANSPLANTATION; RISK; RECIPIENTS; DISEASE; TACROLIMUS; SANDIMMUNE AB Background. Posttransplant lymphoproliferative disorders (PTLD) still represent a major preoccupation after renal transplantation, even in the most recent years. Methods. We analyzed the incidence, risk, and prognostic factors of PTLD in a cohort of kidney recipients using the United States Renal Data System. Results. Among 25,127 Medicare patients transplanted between 1996 and 2000, 344 developed a PTLD defined as a non-Hodgkin lymphoma (1.4%). History of pretransplant malignancy (adjusted hazard ratio [AHR] =3.54, CI 2.31-5.43), younger age (AHR=1.91, CI 1.18-3.1), fewer HLA matches (AHR= 1.32, CI 1.1-1.59) and treatment by ATG (AHR= 1.55, CI 1.2-1.99) and OKT3 (AHR= 1.37, CI 1-1.76), especially if given for rejection therapy were associated with an increased risk of PTLD. Mycophenolate and azathioprine were associated with a lower risk of PTLD (AHR=0.6, CI 0.47-0.78 and AHR=0.66, CI 0.46-0.95, respectively). IL2-receptor inhibitors and sirolinius did not modify the risk of PTLD. Patients without induction therapy treated with tacrolimus were at greater risk of lymphoma than those treated with new formulations of cyclosporine and those treated with antimetabolites (mycophenolate and azathioprine) have a lower risk of PTLD than those without. Patients with PTLD had poor survival (64% vs. 80% at 5 years). Older age, pretransplant malignancy and OKT3 were risk factors for death whereas treatment with mycophenolate was associated with a better survival (AHR=0.49, CI=0.28-0.82). Conclusions. Our study highlights the contribution of patient history and immunosuppression in the risk of PTLD in the era of modern immunosuppression. C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Univ Florida, Pediat Nephrol Serv, Gainesville, FL 32611 USA. NIDDKD, NIH, Bethesda, MD 20892 USA. RP Abbott, K (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM kevin.abbott@na.amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 32 TC 204 Z9 210 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD NOV 15 PY 2005 VL 80 IS 9 BP 1233 EP 1243 DI 10.1097/01.tp.0000179639.98338.39 PG 11 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 990HA UT WOS:000233732600015 PM 16314791 ER PT J AU Raggi, P Taylor, A Fayad, Z O'Leary, D Nissen, S Rader, D Shaw, LJ AF Raggi, P Taylor, A Fayad, Z O'Leary, D Nissen, S Rader, D Shaw, LJ TI Atherosclerotic plaque imaging - Contemporary role in preventive cardiology SO ARCHIVES OF INTERNAL MEDICINE LA English DT Review ID BEAM COMPUTED-TOMOGRAPHY; CORONARY-ARTERY CALCIUM; INTIMA-MEDIA THICKNESS; LIPID-LOWERING THERAPY; RANDOMIZED CONTROLLED-TRIAL; IN-VIVO; INTRAVASCULAR ULTRASOUND; MYOCARDIAL-INFARCTION; CAROTID-ARTERY; HIGH-RESOLUTION AB Coronary artery disease imaging has traditionally been based on luminal angiography, but it has become evident that this tool, although extremely useful in diagnosing obstructive disease, is insufficient to define the presence and extent of atherosclerotic disease in the vessel wall. Progression of coronary artery disease was also initially evaluated using quantitative coronary angiography, and evidence soon accumulated that minor regression or nonprogression of luminal disease was associated with a favorable cardiovascular outcome. In recent years, however, several other techniques have been developed to image atherosclerosis and are emerging as useful tools in preventive cardiovascular medicine. These techniques provide new methods to assess the burden of atherosclerosis, gauge the risk of cardiovascular events, and offer a means to test the efficacy of therapeutic approaches to atherosclerosis. Furthermore, noninvasive coronary angiography can be performed with some of the new imaging modalities, potentially reducing the number of unnecessary invasive tests. This review focuses on techniques such as cardiac computed tomography, carotid artery intima-media thickness, cardiovascular magnetic resonance imaging, and intravascular ultrasonography as emerging tools in cardiovascular disease prevention. C1 Tulane Univ, Sch Med, Dept Internal Med, Cardiol Sect, New Orleans, LA 70112 USA. Walter Reed Army Med Ctr, Div Cardiol, Washington, DC 20307 USA. Mt Sinai Sch Med, Dept Cardiol, New York, NY USA. Mt Sinai Sch Med, Dept Radiol, New York, NY USA. Tufts Univ, New England Med Ctr, Dept Radiol, Boston, MA 02111 USA. Cleveland Clin Fdn, Dept Cardiol, Cleveland, OH 44195 USA. Univ Penn, Dept Internal Med, Div Endocrinol, Philadelphia, PA 19104 USA. Cedars Sinai Med Ctr, Div Cardiol, Los Angeles, CA 90048 USA. RP Raggi, P (reprint author), Tulane Univ, Sch Med, Dept Internal Med, Cardiol Sect, 1430 Tulane Ave,SL-48, New Orleans, LA 70112 USA. EM praggi@excite.com NR 78 TC 23 Z9 23 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD NOV 14 PY 2005 VL 165 IS 20 BP 2345 EP 2353 DI 10.1001/archinte.165.20.2345 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 983SH UT WOS:000233251900005 PM 16287763 ER PT J AU Sheth, JP Unal, S Yilgor, E Yilgor, I Beyer, FL Long, TE Wilkes, GL AF Sheth, JP Unal, S Yilgor, E Yilgor, I Beyer, FL Long, TE Wilkes, GL TI A comparative study of the structure-property behavior of highly branched segmented poly(urethane urea) copolymers and their linear analogs SO POLYMER LA English DT Article DE polyurethanes; highly branched polymers; atomic force microscopy ID BIS(SILYL PINACOLATE) GROUPS; VINYL BLOCK POLYMERS; HYPERBRANCHED POLYURETHANES; POLYDIMETHYLSILOXANE MACROINITIATORS; GLASS-TRANSITION; MOLECULAR-WEIGHT; ENTANGLEMENTS; ELASTOMERS; MELTS AB The solid-state structure-property behavior of highly branched segmented poly(urethane urea) (PUU) copolymers and their linear analog was investigated. A limited study of their solution theological behavior was also undertaken. The linear PUUs were synthesized by the two-step prepolymer method, whereas the oligomeric A(2) + B-3 methodology was utilized to synthesize the highly branched materials. The soft segments (SS) were either poly(tetramethylene oxide) (PTMO) or poly(propylene oxide) (PPO). All copolymers utilized in this study, with one exception, contained 28 wt% hard segment (HS) content. DMA, SAXS, and AFM studies indicated that the linear as well as the highly branched PUUs were microphase separated. The SS T-g of the highly branched PUUs was nearly identical to that of their respective linear analogs. However, the linear copolymers exhibited broader and less temperature sensitive rubbery plateaus, both attributed to one or both of two reasons. The first is better hydrogen bonding organization of the HS phase as well as greater HS lengths than in the highly branched analogs. The second parameter is that of a potentially higher chain entanglement for the linear systems relative to the branched analogs. Tapping-mode AFM phase images confirmed the microphase morphology indicated by SAXS and DMA. Ambient temperature strain-induced crystallization was observed in the PUU based on PTMO 2040 g/mol at a uniaxial strain of ca. 400%, irrespective of the chain architecture. Stress-strain, stress relaxation, and mechanical hysteresis of the highly branched copolymers were in general slightly poorer than that of their linear analogs. Ambient temperature solution viscosity of the highly branched materials in dimethyl formamide was substantially lower that that of the linear samples of nearly equal molecular weight. (c) 2005 Elsevier Ltd. All rights reserved. C1 Virginia Polytech Inst & State Univ, Dept Chem Engn, Blacksburg, VA 24061 USA. Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA. Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey. USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Virginia Polytech Inst & State Univ, Dept Chem Engn, Blacksburg, VA 24061 USA. EM gwilkes@vt.edu RI Unal, Serkan/C-1513-2011; He, Yong/F-8752-2012 OI Unal, Serkan/0000-0003-4423-6202; NR 32 TC 31 Z9 32 U1 4 U2 35 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 EI 1873-2291 J9 POLYMER JI Polymer PD NOV 14 PY 2005 VL 46 IS 23 BP 10180 EP 10190 DI 10.1016/j.polymer.2005.07.068 PG 11 WC Polymer Science SC Polymer Science GA 978SQ UT WOS:000232893700073 ER PT J AU Klinedinst, DB Yilgor, E Yilgor, I Beyer, FL Wilkes, GL AF Klinedinst, DB Yilgor, E Yilgor, I Beyer, FL Wilkes, GL TI Structure-property behavior of segmented polyurethaneurea copolymers based on an ethylene-butylene soft segment SO POLYMER LA English DT Article DE polyurethaneurea; morphology; properties ID BLOCK-COPOLYMERS; MORPHOLOGY; PHASE AB Novel segmented polyurethaneurea copolymers were synthesized using a poly(ethylene-butylene) glycol based soft segment and either hydrogenated diphenyl methane diisocyanate (HMDI) or hexamethylene diisocyanate (HDI) in addition to either ethylene diamine (EDA) or 2-methyl-1,5-diaminopentane (DY) as the chain extender. Dynamic mechanical analysis (DMA), small angle X-ray scattering (SAXS) and in some cases atomic force microscopy (AFM) established the presence of a microphase-separated structure in which hard microdomains are dispersed throughout a soft segment matrix. Wide angle X-ray scattering (WAXS) and differential scanning calorimetry (DSC) imply that the materials are amorphous. Samples that are made with HMDI/DY and have hard segment contents in the range of 16-23 wt% surprisingly exhibit near-linear mechanical deformation behavior in excess of 600% elongation. They also show very high levels of recoverability even though their hysteresis is also considerable. The materials have all proven to be melt processable in addition to solution processable. (c) 2005 Elsevier Ltd. All rights reserved. C1 Virginia Polytech Inst & State Univ, Dept Mat Sci & Engn, Blacksburg, VA 24061 USA. Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey. USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. Virginia Polytech Inst & State Univ, Dept Chem Engn, Polymer Mat & Interfaces Lab, Blacksburg, VA 24061 USA. RP Wilkes, GL (reprint author), Virginia Polytech Inst & State Univ, Dept Mat Sci & Engn, Blacksburg, VA 24061 USA. EM gwilkes@vt.edu RI He, Yong/F-8752-2012 NR 16 TC 40 Z9 40 U1 0 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD NOV 14 PY 2005 VL 46 IS 23 BP 10191 EP 10201 DI 10.1016/j.polymer.2005.07.065 PG 11 WC Polymer Science SC Polymer Science GA 978SQ UT WOS:000232893700074 ER PT J AU Brandt, HE AF Brandt, HE TI Design for a quantum cryptographic entangling probe SO JOURNAL OF MODERN OPTICS LA English DT Article; Proceedings Paper CT 35th Winter Colloquium on the Physics of Quantum Electronics CY JAN 02-06, 2005 CL Snowbird, UT AB I present the design for an optimized entangling probe attacking the BB84 protocol of quantum key distribution and yielding maximum information to the probe. Probe photon polarization states become entangled with the signal states on their way between the legitimate transmitter and receiver. Based on an earlier optimization of the unitary transformation representing the probe for a set error rate induced by the probe, I derive the simplest quantum circuit which faithfully yields the correct entangled state produced by the probe. The quantum circuit consists of a single CNOT gate in which the control qubit is a photon polarization-basis state of the signal, the target is a probe photon polarization basis state, and the initial state of the probe is set by the error rate. A method is determined for measuring the appropriate correlated state of the probe, yielding maximum information to the probe. Finally, a possible implementation of the entangling probe is given. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM hbrandt@arl.army.mil NR 11 TC 5 Z9 5 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0950-0340 J9 J MOD OPTIC JI J. Mod. Opt. PD NOV 10 PY 2005 VL 52 IS 16 BP 2177 EP 2185 DI 10.1080/09500340500275298 PG 9 WC Optics SC Optics GA 982OD UT WOS:000233170600002 ER PT J AU Thathy, V Moulds, JM Guyah, B Otieno, W Stoute, JA AF Thathy, V Moulds, JM Guyah, B Otieno, W Stoute, JA TI Complement receptor I polymorphisms associated with resistance to severe malaria in Kenya SO MALARIA JOURNAL LA English DT Article ID REGULATORY PROTEINS; C3B/C4B RECEPTOR; CEREBRAL MALARIA; BLOOD; CR-1; KNOPS; IDENTIFICATION; SUSCEPTIBILITY; ERYTHROCYTES; EXPRESSION AB Background: It has been hypothesized that the African alleles SI2 and McC(b) of the Swain-Langley (SI) and McCoy (McC) blood group antigens of the complement receptor 1 (CRI) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. Methods: To test this hypothesis, children in western Kenya with severe malaria-associated anaemia or cerebral malaria were matched to symptomatic uncomplicated malaria controls by age and gender. Swain-Langley and McCoy blood group alleles were determined by restriction fragment length polymorphism and conditional logistic regression was carried out. Results: No significant association was found between the African alleles and severe malaria-associated anaemia. However, children with SI2/2 genotype were less likely to have cerebral malaria (OR = 0.17, 95% CI 0.04 to 0.72, P = 0.02) than children with SII/I. In particular, individuals with SI2/2 McC(a/b) genotype were less likely to have cerebral malaria (OR = 0.18, 95% CI 0.04 to 0.77, P = 0.02) than individuals with SI1/1 McC(a/a). Conclusion: These results support the hypothesis that the SI2 allele and, possibly, the McCb allele evolved in the context of malaria transmission and that in certain combinations probably confer a survival advantage on these populations. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA. USA, Med Res Unit, Nairobi, Kenya. Kenya Govt Med Res Ctr, Nairobi, Kenya. Drexel Univ, Coll Med, Dept Immunol & Microbiol, Philadelphia, PA 19104 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. LifeShare Blood Ctr, Shreveport, LA USA. RP Stoute, JA (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA. EM vthathy@wrp-ksm.org; jmmoulds@lifeshare.org; Bguyah@wrp-ksm.org; Wotieno@wrp-ksm.org; jose.stoute@us.army.mil FU FIC NIH HHS [1 D43 TW06239-01, D43 TW006239]; NHLBI NIH HHS [R01 HL 7502-01]; NIAID NIH HHS [R01 AI 42367, R21 AI042367] NR 26 TC 31 Z9 31 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD NOV 8 PY 2005 VL 4 AR 54 DI 10.1186/1475-2875-4-54 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 992QQ UT WOS:000233899300001 PM 16277654 ER PT J AU Du, XL Tove, S Kast-Hutcheson, K Grunden, AM AF Du, XL Tove, S Kast-Hutcheson, K Grunden, AM TI Characterization of the dinuclear metal center of Pyrococcus furiosus prolidase by analysis of targeted mutants SO FEBS LETTERS LA English DT Article DE prolidase; aminopeptidase; dinuclear metal center; cobalt enzyme; Pyrococcus furiosus ID METHIONINE AMINOPEPTIDASE; ESCHERICHIA-COLI; PROLINE DIPEPTIDASE; CULTURED FIBROBLASTS; HUMAN-LIVER; PURIFICATION; DEFICIENCY; ENZYME; SEQUENCE AB Prolidases are dipeptidases specific for cleavage of Xaa-Pro dipeptides. Pyrococcus furiosus prolidase is a homodimer having one Co-bound dinuclear metal cluster per monomer with one tightly bound Co(II) site and the other loosely bound (K-d 0.24 mM). To identify which Co site is tight-binding and which is loose-binding, site-directed mutagenesis was used to modify amino acid residues that participate in binding the Col (E-313 and H-284), the Co2 site (D-209) or the bidentate ligand (E-327). Metal-content, enzyme activity and CD-spectra analyses of D209A-, H284L-, and E327L-prolidase mutants show that Col is the tight-binding and Co2 the loose-binding metal center. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. C1 N Carolina State Univ, Dept Microbiol, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Grunden, AM (reprint author), N Carolina State Univ, Dept Microbiol, Box 7615, Raleigh, NC 27695 USA. EM amy_grunden@ncsu.edu NR 34 TC 17 Z9 18 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-5793 J9 FEBS LETT JI FEBS Lett. PD NOV 7 PY 2005 VL 579 IS 27 BP 6140 EP 6146 DI 10.1016/j.febslet.2005.09.086 PG 7 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 982KT UT WOS:000233157800025 PM 16243319 ER PT J AU McManus, J Mehta, SG McClinton, AR De Lorenzo, RA Baskin, TW AF McManus, J Mehta, SG McClinton, AR De Lorenzo, RA Baskin, TW TI Informed consent and ethical issues in military medical research SO ACADEMIC EMERGENCY MEDICINE LA English DT Article DE ethics; informed consent; military; research; waiver of consent; Department of Defense ID ANTHRAX AB Informed consent in military research shares many of the same fundamental principles and regulations that govern civilian biomedical research. In fact, much of modern research ethics is grounded in events that occurred in the context of war or government-sponsored research. Despite these similarities and common origins, research in the military has additional requirements designed to preserve service members' informed consent rights. The special nature of the superior-sub ordinate relationship in the military necessitates careful protections to avoid perceptions of coercion or undue influence on a military subject. Additionally, current legal and regulatory requirements for advanced informed consent significantly restrict the flexibility of the military to conduct research using waiver of consent. This has implications on the ability of the nation to develop effective medical treatments for the global war on terrorism. Nevertheless, work is under way to realign defense research policy with the norms of civilian biomedical practice. Future directions include the adoption of waivers for military emergency research, and the cautious introduction of human subject studies on the battlefield. This paper discusses historical background, regulatory differences, and concerns and challenges of some of these regulatory differences for research personnel that apply to informed consent and waiver of said informed consent for emergency research conducted by the U.S. military. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. RP McManus, J (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 17 TC 16 Z9 16 U1 1 U2 2 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 USA SN 1069-6563 J9 ACAD EMERG MED JI Acad. Emerg. Med. PD NOV PY 2005 VL 12 IS 11 BP 1120 EP 1126 DI 10.1197/j.aem.2005.05.037 PG 7 WC Emergency Medicine SC Emergency Medicine GA 983JD UT WOS:000233226700020 PM 16264083 ER PT J AU Klote, M AF Klote, M TI Hypersensitivity pneumonitis SO ALLERGY AND ASTHMA PROCEEDINGS LA English DT Article ID FARMERS LUNG; DIAGNOSIS; PROFILE; FLUID AB A case of hypersensitivity pneumonitis (HP) is presented and briefly discussed. The clinical characteristics, diagnosis, pathogenesis, and management of this syndrome are reviewed followed by clinical pearls and pitfalls for the practicing allergist. Most patients with acute HP recover completely with removal from the offending antigen. Treating symptoms only and not avoiding antigen triggers may lead to severe pulmonary fibrosis. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Klote, M (reprint author), 1413 Grady Randall Ct, Mclean, VA 22101 USA. NR 16 TC 3 Z9 3 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1088-5412 J9 ALLERGY ASTHMA PROC JI Allergy Asthma Proc. PD NOV-DEC PY 2005 VL 26 IS 6 BP 493 EP 495 PG 3 WC Allergy SC Allergy GA 000YN UT WOS:000234498500015 PM 16541977 ER PT J AU Arnold, HL Harrison, SA AF Arnold, HL Harrison, SA TI New advances in evaluation and management of patients with polycystic liver disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Review ID BUDD-CHIARI SYNDROME; INTRAHEPATIC PERIBILIARY GLANDS; CONGENITAL HEPATIC-FIBROSIS; VENOUS OUTFLOW OBSTRUCTION; KIDNEY-DISEASE; CYSTIC-DISEASE; DONOR LIVER; LAPAROSCOPIC FENESTRATION; INTRACRANIAL ANEURYSMS; PERCUTANEOUS DRAINAGE AB Adult polycystic liver disease (APLD) is an autosomal dominant condition most commonly associated with polycystic kidney disease. However, over the last decade it has come to be recognized that APLD is a genetically heterogeneous disorder involving derangements on at least three different chromosomes. Mutations involving chromosomes 16 and 4 accounting for autosomal dominant polycystic kidney disease (ADPKD) type 1 and type 2 have been well described as have their gene products, polycystin-1 and polycystin-2. These have since been joined by a more recently recognized mutation in the short arm of chromosome 19 thought to be responsible for a much rarer form of autosomal dominant polycystic liver disease without any associated renal involvement. Despite the sometimes impressive physical and radiologic findings, only a minority of patients will progress to advanced liver disease or develop complications as a result of massive hepatomegaly. In these patients, medical management alone has proved ineffectual. Therefore, in the symptomatic APLD patient, surgical therapy remains the mainstay of therapy and includes cyst aspiration and sclerosis, fenestration with and without hepatic resection and orthotopic liver transplantation. The surgical literature on treatment of APLD, to include outcome measurements and complication rates are summarized. Additionally, we review other potential organ involvement and resultant complications. C1 Brooke Army Med Ctr, Dept Med, Gastroenterol Serv, Ft Sam Houston, TX 78234 USA. RP Arnold, HL (reprint author), Brooke Army Med Ctr, Dept Med, Gastroenterol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 156 TC 56 Z9 58 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD NOV PY 2005 VL 100 IS 11 BP 2569 EP 2582 DI 10.1111/j.1572-0241.2005.00263.x PG 14 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 976ZD UT WOS:000232771300032 PM 16279915 ER PT J AU Smith, B Forkner, E Zaslow, B Krasuski, RA Stajduhar, K Kwan, M Ellis, R Galbreath, AD Freeman, GL AF Smith, B Forkner, E Zaslow, B Krasuski, RA Stajduhar, K Kwan, M Ellis, R Galbreath, AD Freeman, GL TI Disease management produces limited quality-of-life improvements in patients with congestive heart failure: Evidence from a randomized trial in community-dwelling patients SO AMERICAN JOURNAL OF MANAGED CARE LA English DT Article ID GENDER-DIFFERENCES; OUTCOMES; HEALTH; QUESTIONNAIRE; POPULATION; SYSTEM; RESPONSIVENESS; INDIVIDUALS; GUIDELINES; SURVIVAL AB Background: Disease management programs are reported to improve clinical and quality-of-life outcomes while simultaneously lowering healthcare costs. Objective: To examine the effectiveness of disease management in improving health-related quality of life (HRQL) among patients with heart failure beyond 12 months. Methods: A total of 1069 community-dwelling patients 18 years and older in South Texas with echocardiographic evidence of congestive heart failure were randomly assigned to disease management, augmented disease management, and control groups. They were followed up 18 months. Patients in the control group received usual care. Patients in the intervention groups were assigned a registered nurse as a disease manager who performed telephonic patient education and medication management. Health-related quality-of-life data (based on the Medical Outcomes Study 36-item Short-Form Health Survey [SF-36]) were collected 4 times, at 6-month intervals. Results: Disease management has a limited effect on HRQL. Analysis of the SF-36 health transition measure showed a positive effect of the intervention on self-reported improvement in health at 6 months and at 12 months (P = .04 and P = .004, respectively). However, no effect of disease management was observed across any of the SF-36 components. Women and patients with diastolic heart failure had poorer HRQL scores. Conclusions: Participation in disease management has little effect on HRQL outcomes in congestive heart failure. Beneficial effects on the SF-36 scale scores seen at 6 and 12 months were not sustained. Therefore, it is unclear whether disease management can provide long-term improvement in HRQL for patients with congestive heart failure. C1 Univ Texas, Hlth Sci Ctr, Dis Management Ctr, San Antonio, TX 78228 USA. Univ Texas, Hlth Sci Ctr, Altarum Inst, San Antonio, TX 78228 USA. Univ Texas, Hlth Sci Ctr, Div Cardiol, San Antonio, TX 78228 USA. Wilford Hall USAF Med Ctr, Div Cardiol, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Div Cardiol, San Antonio, TX USA. TRICARE SW Reg 6, San Antonio, TX USA. RP Smith, B (reprint author), Univ Texas, Hlth Sci Ctr, Dis Management Ctr, 4243 Piedras Dr E,Suite 240, San Antonio, TX 78228 USA. EM brad.smith@altarum.org NR 50 TC 40 Z9 42 U1 2 U2 6 PU AMER MED PUBLISHING, M W C COMPANY PI JAMESBURG PA 241 FORSGATE DR, STE 102, JAMESBURG, NJ 08831 USA SN 1088-0224 J9 AM J MANAG CARE JI Am. J. Manag. Care PD NOV PY 2005 VL 11 IS 11 BP 701 EP 713 PG 13 WC Health Care Sciences & Services; Health Policy & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 982BR UT WOS:000233132300004 PM 16268753 ER PT J AU Noordzij, JP Goto, MM AF Noordzij, JP Goto, MM TI Airway compromise caused by hematoma after thyroid fine-needle aspiration SO AMERICAN JOURNAL OF OTOLARYNGOLOGY LA English DT Article ID BIOPSY AB Thyroid fine needle aspiration is a very common procedure used to assess thyroid nodules; complications from this procedure are rare. We report an unusual case of a large hematoma of the neck caused by thyroid fine needle aspiration that caused airway compromise. The hematoma was successfully drained via a transcervical approach. In this case report, we also review the literature for the complication rate of this ubiquitous procedure. (c) 2005 Elsevier Inc. All rights reserved. C1 Walter Reed Army Med Ctr, Dept Surg, Otolaryngol Head & Neck Surg Serv, Washington, DC 20307 USA. RP Noordzij, JP (reprint author), Walter Reed Army Med Ctr, Dept Surg, Otolaryngol Head & Neck Surg Serv, Washington, DC 20307 USA. EM jpnoordzij@pol.net NR 7 TC 20 Z9 21 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0196-0709 J9 AM J OTOLARYNG JI Am. J. Otolaryngol. PD NOV-DEC PY 2005 VL 26 IS 6 BP 398 EP 399 DI 10.1016/j.amjoto.2005.02.016 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA 986TQ UT WOS:000233473000007 PM 16275409 ER PT J AU Martini, WJZ Chinkes, DL Pusateri, AE Holcomb, JB Yu, YM Zhang, XJ Wolfe, RR AF Martini, WJZ Chinkes, DL Pusateri, AE Holcomb, JB Yu, YM Zhang, XJ Wolfe, RR TI Acute changes in fibrinogen metabolism and coagulation after hemorrhage in pigs SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM LA English DT Article ID DISSEMINATED INTRAVASCULAR COAGULATION; TRAUMA PATIENTS; EPIDEMIOLOGY AB Hemorrhagic coagulopathy is involved in the morbidity and mortality of trauma patients. Nonetheless, many aspects of the mechanisms underlying this disorder are poorly understood. We have therefore investigated changes in fibrinogen metabolism and coagulation function after a moderate hemorrhagic shock, using a new stable isotope approach. Twelve pigs were randomly divided into the control ( C) and hemorrhage (H) groups. Hemorrhage was induced by bleeding 35% total blood volume over a 30-min period. A primed constant infusion of [1-C-13] phenylalanine (Phe), d(5)-phenylalanine, and alpha-[1-C-13]ketoisocaproate (KIC) was given to quantify fibrinogen synthesis and breakdown, together with measurements of circulating liver enzyme activities and coagulation function. Mean arterial pressure was decreased by hemorrhage from 89 +/- 4 mmHg in C to 47 +/- 4 mmHg in H ( P < 0.05), followed by a rebound to 68 +/- 5 mmHg afterward. Fibrinogen fractional synthesis rate increased from 2.7 +/- 0.2%/ h in C to 4.2 +/- 0.4%/ h in H by Phe ( P < 0.05) and from 3.1 +/- 0.4%/ h in C to 4.4 +/- 0.5%/ h in H by KIC ( P < 0.05). Fibrinogen fractional breakdown rate increased from 3.6 +/- 1.0%/ h in C to 12.9 +/- 1.8%/ h in H ( P < 0.05). The absolute breakdown rate accelerated from 3.0 +/- 0.4 mg center dot kg(-1) center dot h(-1) in C to 5.4 +/- 0.6 mg center dot kg(-1) center dot h(-1) in H ( P < 0.05), but the absolute synthesis rate remained unchanged. These metabolic changes were accompanied by a reduction in blood clotting time to 92.7 +/- 1.6% of the baseline value by hemorrhage ( P < 0.05). No changes were found in liver enzyme activities. We conclude that the observed changes in coagulation after hemorrhagic shock are mechanistically related to the acute acceleration of fibrinogen degradation. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas, Med Branch, Galveston, TX 77550 USA. Harvard Univ, Sch Med, Boston, MA USA. Massachusetts Gen Hosp, Boston, MA 02114 USA. RP Martini, WJZ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 22 TC 43 Z9 45 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1849 J9 AM J PHYSIOL-ENDOC M JI Am. J. Physiol.-Endocrinol. Metab. PD NOV PY 2005 VL 289 IS 5 BP E930 EP E934 DI 10.1152/ajpendo.00137.2005 PG 5 WC Endocrinology & Metabolism; Physiology SC Endocrinology & Metabolism; Physiology GA 977ML UT WOS:000232807800025 PM 15956050 ER PT J AU Latka, M Turalska, M Glaubic-Latka, M Kolodziej, W Latka, D West, BJ AF Latka, M Turalska, M Glaubic-Latka, M Kolodziej, W Latka, D West, BJ TI Phase dynamics in cerebral autoregulation SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE cerebral blood flow; transcranial Doppler sonography; wavelets; synchronization ID BLOOD-FLOW-VELOCITY; NONLINEAR PHYSIOLOGICAL SYSTEMS; INTRACRANIAL-PRESSURE; FRACTAL NATURE; SLOW DYNAMICS; HUMANS; OSCILLATIONS; HEMODYNAMICS; RESPIRATION; VARIABILITY AB Complex continuous wavelet transforms are used to study the dynamics of instantaneous phase difference Delta phi between the fluctuations of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV) in a middle cerebral artery. For healthy individuals, this phase difference changes slowly over time and has an almost uniform distribution for the very low-frequency (0.02-0.07 Hz) part of the spectrum. We quantify phase dynamics with the help of the synchronization index gamma = < sin Delta phi >(2) + < cos Delta phi >(2) that may vary between 0 (uniform distribution of phase differences, so the time series are statistically independent of one another) and 1 ( phase locking of ABP and CBFV, so the former drives the latter). For healthy individuals, the group-averaged index gamma has two distinct peaks, one at 0.11 Hz [gamma = 0.59 +/- 0.09] and another at 0.33 Hz (gamma = 0.55 +/- 0.17). In the very low-frequency range (0.02-0.07 Hz), phase difference variability is an inherent property of an intact autoregulation system. Consequently, the average value of the synchronization parameter in this part of the spectrum is equal to 0.13 +/- 0.03. The phase difference variability sheds new light on the nature of cerebral hemodynamics, which so far has been predominantly characterized with the help of the high-pass filter model. In this intrinsically stationary approach, based on the transfer function formalism, the efficient autoregulation is associated with the positive phase shift between oscillations of CBFV and ABP. However, the method is applicable only in the part of the spectrum (0.1-0.3 Hz) where the coherence of these signals is high. We point out that synchrony analysis through the use of wavelet transforms is more general and allows us to study nonstationary aspects of cerebral hemodynamics in the very low-frequency range where the physiological significance of autoregulation is most strongly pronounced. C1 Wroclaw Tech Univ, Inst Phys, PL-50370 Wroclaw, Poland. Opole Reg Med Ctr, Dept Neurosurg, Opole, Poland. Army Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC USA. RP Latka, M (reprint author), Wroclaw Tech Univ, Inst Phys, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland. EM Miroslaw.Latka@pwr.wroc.pl RI West, Bruce/E-3944-2017 NR 42 TC 53 Z9 53 U1 1 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD NOV PY 2005 VL 289 IS 5 BP H2272 EP H2279 DI 10.1152/ajpheart.01307.2004 PG 8 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA 973BI UT WOS:000232497500063 PM 16024579 ER PT J AU Heppner, DG Walsh, DS Uthaimongkol, N Tang, DB Tulyayon, S Permpanich, B Wimonwattrawatee, T Chuanak, N Laoboonchai, A Sookto, P Brewer, TG McDaniel, P Eamsila, C Yongvanitchit, K Uhl, K Kyle, DE Keep, LW Miller, RE Wongsrichanalai, C AF Heppner, DG Walsh, DS Uthaimongkol, N Tang, DB Tulyayon, S Permpanich, B Wimonwattrawatee, T Chuanak, N Laoboonchai, A Sookto, P Brewer, TG McDaniel, P Eamsila, C Yongvanitchit, K Uhl, K Kyle, DE Keep, LW Miller, RE Wongsrichanalai, C TI Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in western Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FALCIPARUM-MALARIA; CHLOROQUINE; COMBINATION; MEFLOQUINE; CHILDREN; BORDER; DRUGS AB We assessed the prophylactic efficacy of azithromycin (250 mg/day) against malaria in 276 adults in western Thailand in a randomized, double-blind, placebo-controlled trial. After antimalarial suppressive treatment, volunteers were randomized in a 2:1 ratio to either the azithromycin or placebo, respectively. Study medication was given for an average of 74 days. The azithromycin group (n = 179) had five endpoint parasitemias (1 Plasmodium vivax and 4 P. falciparum), and the placebo group (n = 97) had 28 endpoint parasitemias (21 P. vivax, 5 P. falciparum, and 2 mixed infections). Adverse events and compliance and withdrawal rates were similar in both groups. The protective efficacy (PE) of azithromycin was 98% for P. vivax (95% confidence interval [CI] = 88-100%). There were too few cases to reliably estimate the efficacy of azithromycin for P. falciparum (PE = 71%, 95% C = -14-94%). We conclude that daily azithromycin was safe, well-tolerated, and had a high efficacy for the prevention of P. vivax malaria. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. USA Med Component, Dept Immunol & Med, Armed Forces Res Inst Med Sci, Bangkok, Thailand. Kwai River Christian Hosp, Sangkhlaburi, Kanchanaburi Pr, Thailand. Armed Forces Res Inst Med Sci, Thai Component, Div Res, Bangkok 10400, Thailand. USA Med Mat Dev Act, Frederick, MD USA. RP Heppner, DG (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM donald.heppner@na.amedd.army.mil NR 27 TC 24 Z9 26 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2005 VL 73 IS 5 BP 842 EP 849 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 985UR UT WOS:000233404700006 PM 16282291 ER PT J AU Myint, KSA Guan, M Chen, HY Lu, Y Anderson, D Howard, T Noedl, H Mammen, MP AF Myint, KSA Guan, M Chen, HY Lu, Y Anderson, D Howard, T Noedl, H Mammen, MP TI Evaluation of a new rapid immunochromatographic assay for serodiagnosis of acute hepatitis E infection SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE CHAIN-REACTION; E VIRUS; ANTIBODY; RNA AB A rapid and reliable diagnostic assay for acute hepatitis E virus (HEV) infection is needed. We evaluated a rapid, immunochromatographic assay for IgM antibodies to HEV (ASSURE (TM) HEV IgM Rapid Test) using acutephase HEV samples (n = 200) from Indonesia and Nepal and convalescent-phase HEV samples (n = 70) from Nepal. Blood donors in Thailand (n = 100), individuals with hepatitis A (n = 80), hepatitis B (n = 45), and hepatitis C (n = 50) in Thailand and Nepal, acute-phase sera of individuals with Epstein-Barr virus infection (n = 20), and rheumatoid factor-positive blood (n = 26) served as negative controls. The assay had a sensitivity of 93% (95% confidence interval [CI] = 88.5-96.1%) and a specificity of 99.7% (95% CI = 98.3-100%). The positive and negative predictive values were 99.5% (95% CI = 97.1-100%) and 95.8% (95% CI = 93.1-97.7%), respectively. These results suggest that this assay is a sensitive and specific tool for the rapid diagnosis of acute HEV infection. C1 USA, Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. MP Biomed Asia Pacif Pte Ltd, Singapore, Singapore. Macfarlane Burnet Inst Med Res Publ Hlth, Melbourne, Vic, Australia. RP Myint, KSA (reprint author), USA, Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM myintk@afrims.org; ming.guan@mpbio.com; hsiaoying.chen@mpbio.com; yang.lu@mpbio.com; anderson@burnet.edu.au; toward@burnet.edu.au; harald.noedl@afrims.org; mammenmp@afrims.org NR 21 TC 20 Z9 22 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2005 VL 73 IS 5 BP 942 EP 946 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 985UR UT WOS:000233404700023 PM 16282308 ER PT J AU Humberd, CM Murray, CK Stuart, SK Reeb, BA Hospenthal, DR AF Humberd, CM Murray, CK Stuart, SK Reeb, BA Hospenthal, DR TI Short report: Enumerating leptospires using the Coulter counter SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID GROWTH AB The currently accepted gold standard for enumeration of leptospires is tabulation of organisms using a Petroff-Hausser counting chamber and dark-field microscopy, a technically demanding, time-consuming technique. Quantification of leptospires with a Coulter counter produced reliable and reproducible counts, comparable to the counting chamber. This experiment demonstrates that the faster, less technically demanding Coulter counter may be an alternative to determine numbers of leptospires. C1 USAF, Wilford Hall Med Ctr, Dept Infect Dis, Lackland AFB, TX 78236 USA. Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), USAF, Wilford Hall Med Ctr, Dept Infect Dis, 2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA. EM Christina.Humberd@lackland.af.mil; Clinton.Murray@amedd.army.mil NR 7 TC 2 Z9 2 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2005 VL 73 IS 5 BP 962 EP 963 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 985UR UT WOS:000233404700027 PM 16282312 ER PT J AU Lukish, J Cruess, D AF Lukish, J Cruess, D CA Executive Comm Resident Associate TI Personal satisfaction and mentorship are critical factors for today"s resident surgeons to seek surgical training SO AMERICAN SURGEON LA English DT Article; Proceedings Paper CT Annual Meeting of the Southeastern-Surgical-Congress CY FEB 11-15, 2005 CL New Orleans, LA SP SE Surg Congress ID SPECIALTY CHOICE; GENERAL-SURGERY; STUDENTS; CAREER; TRENDS AB The specific aim of this study was to summarize the viewpoints of the Resident and Associate Society of the American College of Surgeons (RAS-ACS) membership regarding current training and quality of life-related issues prior to implementation of the new duty-hour guidelines. The goal was to gain insight of the members that may be useful to recruit and guide the future training of surgical residents. An Internet-based survey was developed to evaluate the viewpoints of RAS-ACS. The survey was administered by Esurveymaker.com via the ACS Web page from 2000 to 2003. RAS-ACS member participation was voluntary and anonymous. Analyses were performed to determine the frequency of response for each survey item. Two hundred thirty-five members completed the survey representing 5 per cent of RAS-ACS. Eighty-four per cent were general surgery residents. Personal satisfaction (64%) and mentorship (49%) were top factors for respondents to pursue surgical training; discussion with colleagues and future income was less important. Forty-five per cent reported that job performance was their most important concern during residency. A rewarding surgical career and family life were ranked as the most important expectations. Eighty-six per cent reported that they were satisfied with their residency, and 66 per cent reported that work hours should be limited. Personal satisfaction and mentorship were critical factors for members of the RAS-ACS to seek surgical training. Although most of the members report that work hours should be limited, an overwhelming majority reports satisfaction with surgical training prior to institution of the new duty-hour guidelines. Further emphasis on mentorship and work-hour reform may be beneficial in recruiting medical students into surgical residencies. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Biostat, Bethesda, MD 20814 USA. Natl Naval Med Res Inst, Washington, DC USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Childrens Natl Med Ctr, Washington, DC 20010 USA. RP Lukish, J (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 13 TC 12 Z9 12 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD NOV PY 2005 VL 71 IS 11 BP 971 EP 974 PG 4 WC Surgery SC Surgery GA 985SH UT WOS:000233398200023 PM 16372617 ER PT J AU Cohen, SP AF Cohen, SP TI Sacroiliac joint pain: A comprehensive review of anatomy, diagnosis, and treatment SO ANESTHESIA AND ANALGESIA LA English DT Review ID LOW-BACK-PAIN; INTRAARTICULAR CORTICOSTEROID INJECTION; MULTICENTER INTERTESTER RELIABILITY; MECHANOSENSITIVE AFFERENT UNITS; PROVOCATION TESTS; SERONEGATIVE SPONDYLARTHROPATHY; ARTHROGRAPHY TECHNIQUE; REFERRAL MAPS; LUMBAR FUSION; DOUBLE-BLIND AB Sacroiliac (SI) joint pain is a challenging condition affecting 15% to 25% of patients with axial low back pain, for which there is no standard long-term treatment. Recent studies have demonstrated that historical and physical examination findings and radiological imaging are insufficient to diagnose SI joint pain. The most commonly used method to diagnose the SI joint as a pain generator is with small-volume local anesthetic blocks, although the validity of this practice remains unproven. In the present review I provide a comprehensive review of the anatomy, function, and mechanisms of injury of the SI joint, along with a systematic assessment of its diagnosis and treatment. C1 Johns Hopkins Med Inst, Pain Management Div, Baltimore, MD 21205 USA. Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Cohen, SP (reprint author), Johns Hopkins Univ Hosp, Pain Management Ctr, Pain Management Div, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 114 TC 113 Z9 124 U1 0 U2 23 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD NOV PY 2005 VL 101 IS 5 BP 1440 EP 1453 DI 10.1213/01.ANE.0000180831.60169.EA PG 14 WC Anesthesiology SC Anesthesiology GA 977DO UT WOS:000232782800032 PM 16244008 ER PT J AU Wilkerson, RC Foster, PG Li, C Sallum, MAM AF Wilkerson, RC Foster, PG Li, C Sallum, MAM TI Molecular phylogeny of neotropical Anopheles (Nyssorhynchus) albitarsis species complex (Diptera : Culicidae) SO ANNALS OF THE ENTOMOLOGICAL SOCIETY OF AMERICA LA English DT Article DE Culicidae; Anopheles albitarsis complex; molecular phylogeny ID POLYMERASE-CHAIN-REACTION; AMPLIFIED POLYMORPHIC DNA; MALARIA VECTOR; COMPARATIVE SUSCEPTIBILITY; BRAZIL; IDENTIFICATION; ARGENTINA; SEQUENCES; MOSQUITOS; RONDONIA AB A phylogeny was reconstructed for four species belonging to the Neotropical Anopheles (Nyssorhynchus) albitarsis complex using partial sequences from the mitochondrial cytochrome oxidase I (COI) and NADH dehydrogenase 4 (ND4) genes and the ribosomal DNA ITS2 and D2 expansion region of the 28S subunit. The basis for initial characterization of each member of the complex was by correlated random amplification of polymorphic DNA-polymerase chain reaction (RAPD-PCR) markers. Analyses were carried out with and without an outgroup (An. (Nys.) argyritarsis Robineau-Desvoidy) by using maximum parsimony, maximum likelihood, and Bayesian methods. A total evidence approach without the outgroup, using separate models for "fast" (COI and ND4 position 3) and "slow" (rDNA ITS2 and D2, and COI and ND4 position 1) partitions, gave the best supported topology, showing close relationships of An. albitarsis Lynch-Arribalzaga to An. albitarsis B and An. marajoara Galvao & Damasceno to An. deaneorum Rosa-Freitas. Analyses with the outgroup included showed poorer support, possibly because of a long branch attraction effect caused by a divergent outgroup, which caused one of the An. marajoara specimens to cluster with An. deaneorum in some analyses. The relationship of the above-mentioned result to a separately proposed hypothesis suggesting a fifth species in the complex is discussed. C1 Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RP Wilkerson, RC (reprint author), Walter Reed Army Inst Res, Dept Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Sallum, Maria/B-8537-2012 FU NIAID NIH HHS [R01 AI054139-03, R01 AI054139] NR 35 TC 27 Z9 27 U1 1 U2 5 PU ENTOMOLOGICAL SOCIETY AMERICA PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0013-8746 J9 ANN ENTOMOL SOC AM JI Ann. Entomol. Soc. Am. PD NOV PY 2005 VL 98 IS 6 BP 918 EP 925 DI 10.1603/0013-8746(2005)098[0918:MPONAN]2.0.CO;2 PG 8 WC Entomology SC Entomology GA 983DD UT WOS:000233210400017 PM 18079976 ER PT J AU Ajariyakhajorn, C Mammen, MP Endy, TP Gettayacamin, M Nisalak, A Nimmannitya, S Libraty, DH AF Ajariyakhajorn, C Mammen, MP Endy, TP Gettayacamin, M Nisalak, A Nimmannitya, S Libraty, DH TI Randomized, placebo-controlled trial of nonpegylated and pegylated forms of recombinant human alpha interferon 2a for suppression of dengue virus viremia in rhesus monkeys SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID CHRONIC HEPATITIS-C; PEGINTERFERON ALPHA-2A; HEMORRHAGIC-FEVER; INTERFERON-ALPHA; MYCOPHENOLIC-ACID; DISEASE SEVERITY; VIRAL-HEPATITIS; INFECTION; REPLICATION; RIBAVIRIN AB Dengue fever and dengue hemorrhagic fever are caused by infection with any one of the four dengue viruses (DVs) and are significant public health burdens throughout the tropics. Higher viremia levels are associated with greater dengue disease severity. A therapeutic intervention to suppress viremia early in DV infection could potentially ameliorate severe disease. Recombinant alpha interferon 2a(rIFN-alpha-2a, Roferon-A) suppressed DV replication in human peripheral blood mononuclear cells in vitro. We therefore examined the effects of rIFN-alpha-2a and pegylated recombinant IFN-alpha-2a (PEG-rIFN-alpha-2a, PEGASYS) on DV serotype 2 (DV-2) viremia in rhesus monkeys. Flavivirus-naive monkeys were inoculated with DV-2 and randomized to receive a single dose of rIFN-alpha-2a (10 million international units/m(2)) versus placebo or PEG-rIFN-alpha-2a (6 mu g/kg) versus placebo 1 day after the onset of viremia. Serial daily viremia levels were measured, and convalescent-phase DV-2 neutralizing antibody titers were determined. Compared to placebo, a single injection of rIFN-alpha-2a temporarily suppressed DV-2 replication and delayed the time to peak viremia by a median of 3 days. However, measures of total viral burden were not different between the two groups. A single injection of PEG-rIFN-a-2a significantly lowered daily viremia levels and improved virus clearance, starting 48 h after administration. There were no significant differences in DV-2 neutralizing antibody titers between the treatment and placebo groups at 30 and 90 days postinfection. Based on their individual effects, future studies should investigate a combination of rIFN-alpha-2a and PEG-rIFN-alpha-2a for suppression of dengue virus viremia and as a potential therapeutic intervention. C1 Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA. Armed Forces Res Inst Med Sci, United State Army Med Component, Bangkok 10400, Thailand. Walter Reed Army Inst Res, Washington, DC 20307 USA. Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. RP Libraty, DH (reprint author), Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Rm S5-326,55 Lake Ave N, Worcester, MA 01655 USA. EM daniel.libraty@umassmed.edu FU NIAID NIH HHS [P01 AI034533, P01 AI34533] NR 45 TC 18 Z9 21 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 2005 VL 49 IS 11 BP 4508 EP 4514 DI 10.1128/AAC.49.11.4508-4514.2005 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 980LV UT WOS:000233020900011 PM 16251289 ER PT J AU Kamimori, GH Johnson, D Thorne, D Belenky, G AF Kamimori, GH Johnson, D Thorne, D Belenky, G TI Multiple caffeine doses maintain vigilance during early morning operations SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE speed; lapses; sleep deprivation; repeated dosing; psychomotor vigilance task ID AIR TRANSPORT OPERATIONS; PERFORMANCE DEGRADATION; COGNITIVE PERFORMANCE; DRIVER SLEEPINESS; MOOD; FATIGUE; SUBSEQUENT; WAKEFULNESS; ACCIDENTS AB Introduction: When used to counteract the effects of sleep deprivation, multiple doses of caffeine are typically ingested across an extended period of time. The goal of this study was to determine the optimal dose of caffeine for sustaining performance during sleep loss with administration of multiple doses. Methods: There were 48 subjects (28 men, 20 women) who were randomly assigned to 1 of 4 groups (placebo, 50, 100, or 200 mg caffeine). After an overnight 8-h sleep period, subjects were required to remain awake for the ensuing 29 h. Control data were collected until 03:00 (Day 3), followed by three 2-h test blocks. At 03:00, 05:00, and 07:00 subjects chewed two sticks of gum (Stay Alert (R) chewing gum) containing caffeine or placebo. Six 10-min sessions on a version of the Psychomotor Vigilance Test (PVT) were completed during each 2-h test block. The Stanford Sleepiness Scale (SSS) was administered after each PVT. Results: Lapses on the PVT were categorized as response times greater than 1, 3, or 5 s. Lapses in all categories significantly increased in the placebo group. Caffeine significantly reduced the number of lapses in a dose-related manner; and performance-was maintained at baseline levels for the entire sleep loss period with multiple doses of 200 mg caffeine. There was a significant main effect for session on the SSS, the score increasing over time, but no significant differences between groups. Discussion: These results indicate that a bi-hourly administration of 200 mg of caffeine maintains vigilance performance across a single night without sleep. C1 Walter Reed Army Inst Res, Dept Behav Biol, Div Neurosci, Silver Spring, MD 20910 USA. RP Kamimori, GH (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Neurosci, 503 Robert Grant Rd,2W97, Silver Spring, MD 20910 USA. EM Gary.Kamimori@us.army.mil NR 30 TC 35 Z9 36 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2005 VL 76 IS 11 BP 1046 EP 1050 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 984EK UT WOS:000233285100007 PM 16313140 ER PT J AU Gabel, F Weik, M Masson, P Renault, F Fournier, D Brochier, L Doctor, BP Saxena, A Silman, I Zaccai, G AF Gabel, F Weik, M Masson, P Renault, F Fournier, D Brochier, L Doctor, BP Saxena, A Silman, I Zaccai, G TI Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: A neutron scattering study SO BIOPHYSICAL JOURNAL LA English DT Article ID MOLTEN GLOBULE STATE; HUMAN BUTYRYLCHOLINESTERASE; PROTEIN DYNAMICS; DROSOPHILA ACETYLCHOLINESTERASE; MOUSE ACETYLCHOLINESTERASE; CONFORMATIONAL ENTROPY; TEMPERATURE-DEPENDENCE; VIBRATIONAL ENTROPY; CRYSTAL-STRUCTURE; N-GLYCOSYLATION AB Incoherent elastic neutron scattering experiments on members of the cholinesterase family were carried out to investigate how molecular dynamics is affected by covalent inhibitor binding and by differences in primary and quaternary structure. Tetrameric native and soman-inhibited human butyrylcholinesterase (HuBChE) as well as native dimeric Drosophila melanogaster acetylcholinesterase ( DmAChE) hydrated protein powders were examined. Atomic mean-square displacements (MSDs) were found to be identical for native HuBChE and for DmAChE in the whole temperature range examined, leading to the conclusion that differences in activity and substrate specificity are not reflected by a global modification of subnanosecond molecular dynamics. MSDs of native and soman-inhibited HuBChE were identical below the thermal denaturation temperature of the native enzyme, indicating a common mean free-energy surface. Denaturation of the native enzyme is reflected by a relative increase of MSDs consistent with entropic stabilization of the unfolded state. The results suggest that the stabilization of HuBChE phosphorylated by soman is due to an increase in free energy of the unfolded state due to a decrease in entropy. C1 Inst Biol Struct, Mol Biophys Lab, Grenoble, France. Ctr Rech, Serv Sante Armees, Unite Enzymol, La Tronche, France. Inst Pharmacol & Biol Struct, Toulouse, France. Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA. Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel. Inst Max Von Laue Paul Langevin, F-38042 Grenoble, France. RP Weik, M (reprint author), CEA, CNRS, Inst Biol Struct, 41 Rue Jules Horowitz, F-38027 Grenoble, France. EM weik@ibs.fr RI Masson, Patrick/J-3964-2013 OI Masson, Patrick/0000-0002-7837-3662 NR 66 TC 10 Z9 10 U1 0 U2 6 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD NOV PY 2005 VL 89 IS 5 BP 3303 EP 3311 DI 10.1529/biophysj.105.061028 PG 9 WC Biophysics SC Biophysics GA 979HP UT WOS:000232933300044 PM 16100272 ER PT J AU Mainster, MA Silney, DH AF Mainster, MA Silney, DH TI TTT: local light absorption and heat convection versus heat conduction SO BRITISH JOURNAL OF OPHTHALMOLOGY LA English DT Letter ID TRANSPUPILLARY THERMOTHERAPY; TEMPERATURE C1 Univ Kansas, Sch Med, Dept Ophthalmol, Kansas City, KS 66160 USA. USA, Laser Opt Radiat Program, Environm Hyg Agcy, Aberdeen Proving Ground, MD 21010 USA. RP Mainster, MA (reprint author), Univ Kansas, Sch Med, Dept Ophthalmol, M53009,3901 Rainbow Blvd, Kansas City, KS 66160 USA. EM mmainster@kumc.edu NR 6 TC 1 Z9 1 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0007-1161 J9 BRIT J OPHTHALMOL JI Br. J. Ophthalmol. PD NOV PY 2005 VL 89 IS 11 BP 1544 EP 1545 DI 10.1136/bjo.2005.082453 PG 2 WC Ophthalmology SC Ophthalmology GA 975HQ UT WOS:000232652000050 ER PT J AU Wolf, SE AF Wolf, SE TI Untitled SO BURNS LA English DT Editorial Material C1 Univ Texas, Hlth Sci Ctr, Dept Surg, Brooke Army Med Ctr,USA Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Wolf, SE (reprint author), Univ Texas, Hlth Sci Ctr, Dept Surg, Brooke Army Med Ctr,USA Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM Steven.Wolf@cen.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD NOV PY 2005 VL 31 IS 7 BP 805 EP 810 DI 10.1016/j.burns.2005.09.001 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 978GM UT WOS:000232861600001 ER PT J AU Paskett, ED Reeves, KW Pineau, B Albert, PS Caan, B Hasson, M Iber, F Kikendall, JW Lance, P Shike, M Slattery, ML Weissfeld, J Kahle, L Schatzkin, A Lanza, E AF Paskett, ED Reeves, KW Pineau, B Albert, PS Caan, B Hasson, M Iber, F Kikendall, JW Lance, P Shike, M Slattery, ML Weissfeld, J Kahle, L Schatzkin, A Lanza, E CA Polyp Prevention Trial Study Grp TI The association between cigarette smoking and colorectal polyp recurrence (United States) SO CANCER CAUSES & CONTROL LA English DT Article DE colonic polyps; recurrence; smoking ID HYPERPLASTIC POLYPS; ADENOMATOUS POLYPS; RISK-FACTORS; FOLLOW-UP; ALCOHOL-CONSUMPTION; TOBACCO SMOKING; PROSPECTIVE COHORT; BRITISH DOCTORS; CANCER RISK; MORTALITY AB Objective: Although evidence exists linking smoking to precancerous colorectal adenomatous polyps, few studies have examined the association between cigarette smoking and recurrence of colorectal polyps. This association was investigated prospectively with data from the Polyp Prevention Trial. Methods: Cigarette smoking data were collected through baseline interviews. The study was completed by 1872 men and women with presence of adenomas at baseline colonoscopy. Multiple logistic regression analysis was used to examine the association between cigarette smoking and polyp recurrence (adenomatous and hyperplastic) up to four years from baseline. Results: Adenoma recurrence was not related to cigarette smoking. Current smokers had increased odds of hyperplastic polyps at follow-up compared to never smokers (OR 2.88, 95% CI 2.06-4.01). Current smoking was associated with subsequent distal (OR 3.44, 95% CI 2.38-4.95) and rectal (OR 3.53, 95% CI 2.15-5.78) hyperplastic polyps, but not subsequent proximal hyperplastic polyps. Cigarette smoking was associated with subsequent multiple and small size (4 mm) hyperplastic polyps. Significant linear trends were observed between development of subsequent hyperplastic polyps and all smoking variables. Conclusions: Although no association with recurrent adenomas was observed, cigarette smoking was significantly associated with hyperplastic polyp development, except for those in the proximal colon. This prospective study confirms that cigarette smoking has a significant effect on the development of hyperplastic colorectal polyps. C1 Ohio State Univ, Ctr Comprehens Canc, Div Populat Sci, Columbus, OH 43210 USA. First Coast Gastroenterol, St Augustine, FL USA. NCI, Biometr Res Branch, Div Canc Treatment & Diag, Bethesda, MD 20892 USA. Kaiser Fdn Res Inst, Oakland, CA USA. WESTAT Corp, Rockville, MD 20850 USA. Edward Hines Jr Hosp, Vet Affairs Med Ctr, Hines, IL USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA. Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. Univ Utah, Salt Lake City, UT USA. Univ Pittsburgh, Pittsburgh, PA USA. Informat Management Serv Inc, Rockville, MD USA. NCI, Nutr Epidemiol Branch, Div Epidemiol & Genet, Bethesda, MD 20892 USA. NCI, Lab Canc Prevent, Ctr Canc Res, Bethesda, MD 20892 USA. RP Ohio State Univ, Ctr Comprehens Canc, Div Populat Sci, A357 Starling Loving Hall,320 W 10th Ave, Columbus, OH 43210 USA. EM paskett-1@medctr.osu.edu RI Lance, Peter/I-2196-2014 OI Lance, Peter/0000-0003-2944-1881 NR 68 TC 19 Z9 20 U1 1 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 EI 1573-7225 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD NOV PY 2005 VL 16 IS 9 BP 1021 EP 1033 DI 10.1007/s10552-005-0298-2 PG 13 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 968CQ UT WOS:000232139900003 PM 16184467 ER PT J AU Sciuto, AM Phillips, CS Orzolek, LD Hege, AI Moran, TS Dillman, JF AF Sciuto, AM Phillips, CS Orzolek, LD Hege, AI Moran, TS Dillman, JF TI Genomic analysis of murine pulmonary tissue following carbonyl chloride inhalation SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID BRONCHOALVEOLAR LAVAGE FLUID; ACUTE LUNG INJURY; ANTIOXIDANT ENZYMES; GAS PHOSGENE; MICE; EXPRESSION; EXPOSURE; GLUTATHIONE; RABBITS; CELLS AB Carbonyl chloride (phosgene) is a toxic industrial compound widely used in industry for the production of synthetic products, such as polyfoam rubber, plastics, and dyes. Exposure to phosgene results in a latent (1-24 h), potentially life-threatening pulmonary edema and irreversible acute lung injury. A genomic approach was utilized to investigate the molecular mechanism of phosgene-induced lung injury. CD-1 male mice were exposed whole body to either air or a concentration x time amount of 32 mg/m(3) (8 ppm) phosgene for 20 min (640 mg x min/m(3)). Lung tissue was collected from air- or phosgene-exposed mice at 0.5, 1, 4, 8, 12, 24, 48, and 72 h postexposure. RNA was extracted from the lung and used as starting material for the probing of oligonucleotide microarrays to determine changes in gene expression following phosgene exposure. The data were analyzed using principal component analysis to determine the greatest sources of data variability. A three-way analysis of variance based on exposure, time, and sample was performed to identify the genes most significantly changed as a result of phosgene exposure. These genes were rank ordered by p values and categorized based on molecular function and biological process. Some of the most significant changes in gene expression reflect changes in glutathione synthesis and redox regulation of the cell, including upregulation of glutathione S-transferase alpha-2, glutathione peroxidase 2, and glutamate-cysteine ligase, catalytic subunit (also known as gamma-glutamyl cysteine synthetase). This is in agreement with previous observations describing changes in redox enzyme activity after phosgene exposure. We are also investigating other pathways that are responsive to phosgene exposure to identify mechanisms of toxicity and potential therapeutic targets. C1 USA, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. USA, Appl Pharmacol Branch, Div Pharmacol, Aberdeen Proving Ground, MD 21010 USA. RP Sciuto, AM (reprint author), USA, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. EM alfred.mario.sciuto@us.army.mil OI Harrill, Alison/0000-0001-9429-1897 NR 24 TC 26 Z9 28 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD NOV PY 2005 VL 18 IS 11 BP 1654 EP 1660 DI 10.1021/tx050126f PG 7 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 987EE UT WOS:000233500400004 PM 16300373 ER PT J AU Hewitt, AD Jenkins, TF Walsh, ME Walsh, MR Taylor, S AF Hewitt, AD Jenkins, TF Walsh, ME Walsh, MR Taylor, S TI RDX and TNT residues from live-fire and blow-in-place detonations SO CHEMOSPHERE LA English DT Article DE explosives; detonation residues; live-fire; blow-in-place ID RANGES AB Snow was used as a collection medium to examine 1,3,5-hexahydro-1,3,5-trinitrotriazine (RDX) and 2,4,6-trinitrotoluene (TNT) residues post-detonation of 60-, 81-, and 120-mm mortar rounds, 105- and 155-mm howitzer rounds, M67 hand grenades, 40-mm rifle grenades, and blocks of C4. Residue-covered snow samples were collected, processed, and analyzed for explosives without cross-contamination from previous detonations and other potential matrix interferences. Detonation trials were performed following standard military live-fire and blow-in-place techniques. When possible, replicate munitions were detonated under similar conditions to provide a more reliable estimation of the mass of unconsumed high explosive residues. Overall the amount of energetic residues deposited from live-fire detonations were considerably less than the energetic residues deposited by blow-in-place detonations. (c) 2005 Elsevier Ltd. All rights reserved. C1 USA, Cold Reg Res & Engn Lab, Ctr Res Dev & Engn, Hanover, NH 03755 USA. RP Hewitt, AD (reprint author), USA, Cold Reg Res & Engn Lab, Ctr Res Dev & Engn, 72 Lyme Rd, Hanover, NH 03755 USA. EM ahewitt@crrel.usace.army.mil NR 15 TC 28 Z9 28 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD NOV PY 2005 VL 61 IS 6 BP 888 EP 894 DI 10.1016/j.chemosphere.2005.04.058 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 982VF UT WOS:000233189000015 PM 15964048 ER PT J AU Ouellette, DR AF Ouellette, DR TI The impact of anemia in patients with respiratory failure SO CHEST LA English DT Article DE anemia oxygen delivery; respiratory failure; transfusion; intensive care ID CRITICALLY-ILL PATIENTS; ALLOGENEIC BLOOD-TRANSFUSION; CRITICAL OXYGEN DELIVERY; MECHANICAL VENTILATION; POSTOPERATIVE DURATION; TISSUE HYPOXIA; CRITICAL-CARE; TRANSPORT; PREDICTORS; TRIAL AB Healthy individuals are able to tolerate profound, short-term decreases in hemoglobin levels and oxygen saturation without serious consequences, but critically ill patients in respiratory failure lack the necessary reserve capacity to preserve tissue oxygenation. The development of progressive anemia in ICU patients has led to much interest and debate about transfusion practices, yet optimal hemoglobin levels and how they should be achieved remain unclear. Animal and human studies regarding critical oxygen delivery, provide the rationale for optimizing hemoglobin levels and supporting cardiovascular function during respiratory failure. Theoretically, the oxygen-carrying benefit of RBCs should hasten recovery from respiratory failure, and transfusions would therefore be expected to shorten the duration of mechanical ventilation. However, evidence to the contrary has been reported. Controversies related to transfusions and their inability to improve outcomes suggest that further research regarding transfusion alternatives is needed, especially in anemic patients with respiratory failure. C1 Brooke Army Med Ctr, Dept Pulm & Crit Care Med, Ft Sam Houston, TX 78234 USA. RP Ouellette, DR (reprint author), Brooke Army Med Ctr, Dept Pulm & Crit Care Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM DanielRQuellette@aol.com NR 34 TC 7 Z9 7 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 2005 VL 128 IS 5 SU 2 BP 576S EP 582S DI 10.1378/chest.128.5_suppl_2.576S PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 988MO UT WOS:000233605500005 PM 16306056 ER PT J AU Shorr, AF Kollef, MH AF Shorr, AF Kollef, MH TI Ventilator-associated pneumonia - Insights from recent clinical trials SO CHEST LA English DT Article DE antibiotic resistance; antibiotic therapy; ventilator-associated pneumonia ID INTENSIVE-CARE-UNIT; POSTOPERATIVE BACTERIAL-INFECTION; ALLOGENEIC BLOOD-TRANSFUSION; NOSOCOMIAL INFECTIONS; MECHANICAL VENTILATION; ANTIBIOTIC-THERAPY; CELL TRANSFUSION; RANDOMIZED-TRIAL; RISK-FACTOR; PREVENTION AB Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in the ICU and contributes disproportionately to both poor outcomes and the high cost of care in critically ill patients. While VAP has been the focus of extensive research, little consensus exists about methods for diagnosis, treatment, or prevention. Delays in initiating appropriate therapy, antibiotic resistance due to indiscriminate and prolonged use of broad-spectrum antibiotics, and treatment of patients with a low risk of VAP (based on clinical pulmonary infection scores) represent a sample of VAP-related issues that have been addressed in recent clinical trials. Educational programs for VAP prevention and other nonpharmacologic strategies aimed at eliminating VAT have also been explored in clinical investigations. This review highlights selected areas of new clinical research on VAP treatment and prevention in order to place their significance in context. C1 Walter Reed Army Med Ctr, Dept Med, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. Washington Univ, Barnes Jewish Hosp, Sch Med, Div Pulm & Crit Care, St Louis, MO USA. RP Shorr, AF (reprint author), Washington Hosp Ctr, Washington, DC 20010 USA. EM afshorr@mail.dnamail.com NR 45 TC 24 Z9 27 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 2005 VL 128 IS 5 SU 2 BP 583S EP 591S DI 10.1378/chest.128.5_suppl_2.583S PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 988MO UT WOS:000233605500006 PM 16306057 ER PT J AU Selecky, PA Eliasson, CAH Hall, RI Schneider, RF Varkey, B McCaffree, R AF Selecky, PA Eliasson, CAH Hall, RI Schneider, RF Varkey, B McCaffree, R CA ACCP Ethics Comm TI Palliative and end-of-life care for patients with cardiopulmonary diseases SO CHEST LA English DT Article DE advance directives; hospice care; palliative care; right to die; spirituality; terminal care ID TERMINALLY-ILL PATIENTS; PHYSICIAN-ASSISTED SUICIDE; ADVANCE DIRECTIVES; CANCER-PATIENTS; INTENSIVE-CARE; SUSTAINING THERAPY; METASTATIC CANCER; MEDICAL-EDUCATION; MEASURING QUALITY; COMMON SYMPTOMS AB Acute and chronic pulmonary and cardiac diseases often have a high mortality rate, and can be a source of significant suffering. Palliative care, as described by the Institute of Medicine, "seeks to prevent, relieve, reduce or soothe the symptoms of disease or disorder without effecting a cure... Palliative care in this broad sense is not restricted to those who are dying or those enrolled in hospice programs." The American College of Chest Physicians strongly supports the position that such palliative and end-of-life care of the patient with an acute devastating or chronically, progressive pulmonary or cardiac disease and his/her family should be an integral part of cardiopulmonary medicine. This care is best provided through an interdisciplinary effort by competent and experienced professionals under the leadership of a knowledgeable and compassionate physician. To that end, it is hoped that this statement will serve as a framework within which physicians may develop their own approach to the management of patients requiring palliative care. C1 Hoag Mem Hosp, Newport Beach, CA 92658 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Queen Elizabeth II HSC, Halifax, NS, Canada. Beth Israel Med Ctr, New York, NY 10003 USA. Med Coll Wisconsin, Milwaukee, WI 53226 USA. RP Selecky, PA (reprint author), Hoag Mem Hosp, 1 Haog Dr,POB 6100, Newport Beach, CA 92658 USA. EM pselecky@hoaghospital.org NR 97 TC 70 Z9 72 U1 2 U2 7 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 2005 VL 128 IS 5 BP 3599 EP 3610 DI 10.1378/chest.128.5.3599 PG 12 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 987HG UT WOS:000233508400076 PM 16304319 ER PT J AU Huynh, LT Kim, SY Murphy, TF AF Huynh, LT Kim, SY Murphy, TF TI The typical appearance of focal nodular hyperplasia in triple-phase CT scan, hepatobiliary scan, and Tc-99m sulfur colloid scan with SPECT SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE focal nodular hyperplasia; hepatobiliary scan; sulfur colloid scan; SPECT; triple-phase CT scan ID MULTIPHASIC HELICAL CT; LIVER; SCINTIGRAPHY; DIAGNOSIS; ADENOMA C1 Tripler Army Med Ctr, MCHKME, Trplier AMC, Honolulu, HI 96859 USA. Womack Army Med Ctr, Ft Bragg, NC USA. RP Huynh, LT (reprint author), Tripler Army Med Ctr, MCHKME, Trplier AMC, 1 Jarret White Rd, Honolulu, HI 96859 USA. EM lien.huynh@haw.tamc.amedd.army.mil NR 12 TC 5 Z9 7 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD NOV PY 2005 VL 30 IS 11 BP 736 EP 739 DI 10.1097/01.rlu.0000182266.17359.99 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 976OB UT WOS:000232741900008 PM 16237299 ER PT J AU Piesman, M Hwang, I Moses, FM Allen, TW AF Piesman, M Hwang, I Moses, FM Allen, TW TI Duodenal diverticulum presenting as a hypermetabolic mass on F-18FDG PET/CT SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE FDG; PET/CT; false-positive; duodenum; diverticulum ID POSITRON-EMISSION-TOMOGRAPHY C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Piesman, M (reprint author), Walter Reed Army Med Ctr, Bldg 2,Room 7F47,6900 Georgia Ave, Washington, DC 20307 USA. EM michael.piesman@na.amedd.army.mil NR 9 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD NOV PY 2005 VL 30 IS 11 BP 747 EP 748 DI 10.1097/01.rlu.0000182273.15443.dd PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 976OB UT WOS:000232741900012 PM 16237303 ER PT J AU Gokce, A Chohra, M Advani, SG Walsh, SM AF Gokce, A Chohra, M Advani, SG Walsh, SM TI Permeability estimation algorithm to simultaneously characterize the distribution media and the fabric preform in vacuum assisted resin transfer molding process SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE resin transfer molding; fabrics/textiles; hybrid compounds; modelling; permeability ID FIBROUS REINFORCEMENTS; FLOW; PRESSURE; FLUID; MODEL AB In vacuum assisted resin transfer molding (VARTM), available pressure for resin injection is limited to 1 atm. Therefore, layers of high-permeability fabrics, called the distribution media (DM), are included in the lay-up to enhance the resin flow. During injection, resin flows initially in-plane saturating the DM, and subsequently through the thickness impregnating the bulk preform. Therefore, the DM permeability governs the planar resin flow pattern and lead length, which is defined as the difference between the flow position in the DM and in the bottom preform layer adjacent to the tool surface. In this study, the DM permeability was investigated as a function of the preform lay-up. A new permeability estimation method, called permeability estimation algorithm (PEA), that can estimate permeability values of the DM and the preform simultaneously from a single experiment, was developed and validated. Using PEA, it has been shown that the DM permeability does vary with the preform lay-up. (c) 2005 Elsevier Ltd. All rights reserved. C1 Univ Delaware, Dept Mech Engn, Ctr Composite Mat, Newark, DE 19716 USA. USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Advani, SG (reprint author), Univ Delaware, Dept Mech Engn, Ctr Composite Mat, Newark, DE 19716 USA. EM advani@me.udel.edu NR 29 TC 23 Z9 23 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD NOV PY 2005 VL 65 IS 14 BP 2129 EP 2139 DI 10.1016/j.compscitech.2005.05.012 PG 11 WC Materials Science, Composites SC Materials Science GA 972LD UT WOS:000232454400006 ER PT J AU Elston, DM Vinson, R AF Elston, DM Vinson, R TI What is your diagnosis? The diagnosis: Lymphangioma circumscriptum (Benign lymphangiectasia) SO CUTIS LA English DT Editorial Material ID CARBON-DIOXIDE LASER; SQUAMOUS-CELL CARCINOMA; SURGICAL-MANAGEMENT; THERAPY; VAPORIZATION; CERVIX C1 Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. Geisinger Med Ctr, Dept Lab Med, Danville, PA 17822 USA. Brooke Army Med Ctr, Dept Dermatol, Ft Sam Houston, TX 78234 USA. RP Elston, DM (reprint author), Geisinger Med Ctr, Dept Dermatol, Danville, PA 17822 USA. NR 41 TC 0 Z9 0 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI CHATHAM PA 26 MAIN ST, STE A, CHATHAM, NJ 07928-2402 USA SN 0011-4162 J9 CUTIS JI Cutis PD NOV PY 2005 VL 76 IS 5 BP 301 EP + PG 4 WC Dermatology SC Dermatology GA 986LR UT WOS:000233451600003 PM 16422464 ER PT J AU Oh, SY Cha, DK Kim, BJ Chiu, PC AF Oh, SY Cha, DK Kim, BJ Chiu, PC TI Reductive transformation of hexahydro-1,3,5-trinitro-1,3,5-triazine, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine, and methylenedinitramine with elemental iron SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE elemental iron; reduction; hexahydro-1,3,5-trinitro-1,3,5-triazine; octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine; methylenedinitramine ID ZERO-VALENT IRON; MUNICIPAL ANAEROBIC SLUDGE; RDX-CONTAMINATED WATER; ELECTROCHEMICAL REDUCTION; CATALYZED DECOMPOSITION; ALKALINE-HYDROLYSIS; ZEROVALENT IRON; EXPLOSIVES RDX; CAST-IRON; BIODEGRADATION AB Reductive (pre)treatment with elemental iron is a potentially useful method for degrading nitramine explosives in water and soil. In the present study, we examined the kinetics, products, and mechanisms of hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) degradation with elemental iron. Both RDX and HMX were transformed with iron to formaldehyde, NH4+, N2O, and soluble products. The yields of formaldehyde were relatively constant (71% +/- 5%), whereas the yields of NH4+ and N2O varied, depending on the nitramine and the mechanism. The reactions most likely were controlled by a surface process rather than by external mass transfer. Methylenedinitramine (MDNA) was an intermediate of both RDX and HMX and was transformed quantitatively to formaldehyde with iron. However, product distributions and kinetic modeling results suggest that MDNA represented a minor reaction path and accounted for only 30% of the RDX reacted and 14% of the formaldehyde produced. Additional experiments showed that RDX reduction with elemental iron could be mediated by graphite and Fe2+ sorbed to magnetite, as demonstrated previously for nitroaromatics and nitrate esters. Methylenedinitramine was degraded primarily through reduction in the presence of elemental iron, because its hydrolysis was slow compared to its reactions with elemental iron and surface-bound Fe2+. Our results show that in a cast iron-water system, RDX may be transformed via multiple mechanisms involving different reaction paths and reaction sites. C1 Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. USA, Ctr Res Dev & Engn, Champaign, IL 61826 USA. RP Chiu, PC (reprint author), Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. EM pei@ce.udel.edu NR 61 TC 26 Z9 26 U1 2 U2 12 PU SETAC PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 2005 VL 24 IS 11 BP 2812 EP 2819 DI 10.1897/04-662R.1 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 974WJ UT WOS:000232621800014 PM 16398117 ER PT J AU Rosen, G Lotufo, GR AF Rosen, G Lotufo, GR TI Toxicity and fate of two munitions constituents in spiked sediment exposures with the marine amphipod Eohaustorius estuarius SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE 2,4,6-trinitrotoluene; hexahydro-1,3.5-trinitro-1,3,5-triazine; Eohaustorius estuarius; critical body residue ID SOIL ORGANIC-MATTER; MILITARY FACILITIES; COVALENT BINDING; SURFACE SOILS; PICRIC ACID; N-15 NMR; 2,4,6-TRINITROTOLUENE; TNT; EXPLOSIVES; DEGRADATION AB The lethal toxicity of the explosive compounds C-14-labeled 2,4,6-trinitrotoluene (TNT) and nonradiolabeled hexahydro-1.3.5-trinitro-1.3.5-triazine (RDX) to the estuarine amphipod Eohaustorius estuarius was investigated in 10-d spiked sediment exposures. The 10-d median lethal concentration (LC50) was determined using the sum molar initial concentration of TNT. aminodinitrotoluenes (ADNTs), and diaminonitrotoluenes (DANTs), as determined by high-performance liquid chromatography (HPLC), and collectively referred to as HPLC-TNT*. Despite expectations of higher toxicity in sandy sediment (Yaquina Bay [YB], OR, USA) compared to relatively fine-grained sediment (San Diego Bay [SDB], CA, USA), LC50 values were similar: 159 and 125 mu mol/Kg, for YB and SDB sediments, respectively. When expressed as the sum of TNT and all its degradation products (C-14-TNT*), LC50s were approximately two times the corresponding LC50s determined by HPLC. The HPLC-TNT* fraction likely corresponds to the most bioavailable and toxic transformation products. The concentrations of C-14-TNT* in tissues were substantially higher than those for HPLC-TNT*, suggesting that compounds other than TNT and its major aminated transformation products were prevalent. Critical body residues were similar for exposures to SDB (11.7 mu mol/kg) and YB sediments (39.4 mu mol/kg), despite marked differences in the nature of compounds available for uptake in the exposure media. The critical body residues for E. estuarills are lower than those reported for other aquatic invertebrates (83-172 mu mol/kg). Unlike observations for TNT, RDX was only loosely associated with SDB sediment, with near complete recovery of the parent compound by chemical analysis. Exposure to RDX did not result in significant mortality even at the highest measured sediment concentration of 10,800 mu mol/kg dry weight, nor tissue concentrations as high as 96 mu mol/kg wet weight. The lack of RDX lethal effects in this study is consistent with results reported for other invertebrate species. C1 Space & Naval Warfare Syst Ctr, San Diego, CA 92152 USA. USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Rosen, G (reprint author), Space & Naval Warfare Syst Ctr, 53475 Strothe Rd, San Diego, CA 92152 USA. EM gunther.rosen@navy.mil NR 54 TC 27 Z9 28 U1 0 U2 8 PU SETAC PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 2005 VL 24 IS 11 BP 2887 EP 2897 DI 10.1897/04-611R.1 PG 11 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 974WJ UT WOS:000232621800023 PM 16398126 ER PT J AU Chaturvedi, A Mehta, S Dolk, D Ayer, R AF Chaturvedi, A Mehta, S Dolk, D Ayer, R TI Agent-based simulation for computational experimentation: Developing an artificial labor market SO EUROPEAN JOURNAL OF OPERATIONAL RESEARCH LA English DT Article DE artificial intelligence; decision support systems; simulation; modelling systems and languages; economics ID ARMY AB This paper discusses the creation of an artificial labor market (ALM) as an agent-based simulation model. We trace the development of the ALM by adapting the traditional simulation life cycle into two main parts: the model phase and the simulation phase. In the modeling phase of the life cycle, we focus upon agent representation and specification within the virtual world. In the simulation phase, we discuss the use of scenario planning as the experimentation vehicle. Throughout, we use military recruit market as an example to illustrate the methodology. The benefits of the ALM are (1) it provides a virtual world for continuous computational experimentation, (2) it supports market segmentation by allowing "drilldowns" to finer and finer levels of granularity, and (3) when connected via a common OLAP interface to a "real world" counterpart, it facilitates a tightly integrated, persistent, "sense and respond" decision support functionality. (c) 2004 Elsevier B.V. All rights reserved. C1 USN, Postgrad Sch, Dept Informat Sci, Monterey, CA 93943 USA. Purdue Univ, Krannert Sch Management, W Lafayette, IN 47907 USA. USA, Access Command, Ft Knox, KY USA. RP Dolk, D (reprint author), USN, Postgrad Sch, Dept Informat Sci, Monterey, CA 93943 USA. EM drdolk@nps.navy.mil NR 34 TC 8 Z9 9 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-2217 J9 EUR J OPER RES JI Eur. J. Oper. Res. PD NOV 1 PY 2005 VL 166 IS 3 BP 694 EP 716 DI 10.1016/j.ejor.2004.03.040 PG 23 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA 931PT UT WOS:000229498000007 ER PT J AU Parker, JD Sinaii, N Segars, JH Godoy, H Winkel, C Stratton, P AF Parker, JD Sinaii, N Segars, JH Godoy, H Winkel, C Stratton, P TI Adhesion formation after laparoscopic excision of endometriosis and lysis of adhesions SO FERTILITY AND STERILITY LA English DT Article; Proceedings Paper CT 51st Annual Meeting of the Society-for-Gynecologic-Investigation CY MAR 24-27, 2004 CL Houston, TX SP Soc Gynecol Invest DE endometriosis; laser surgery; adhesion formation; chronic pelvic pain ID PERITONEAL ADHESIONS; 2ND-LOOK LAPAROSCOPY; NERVE-FIBERS; SURGERY; PREVENTION; REFORMATION AB Objective: To evaluate adhesion reformation after laparoscopic excision of endometriosis and adhesiolysis in women with chronic pelvic pain. Design: Prospective clinical trial. Setting: University hospital. Patient(s): Thirty-eight women with endometriosis and chronic pelvic pan. Intervention(s): A primary and second-look laparoscopy with adhesiolysis and excision of endometriotic lesions with a neodymium yttrium argon garnet surgical laser technologies (SLT) contact laser. Main Outcome Measure(s): Adhesion formation and character (thin, thin and thick, or think). Location of adhesions at a first laparoscopy was compared with de novo or reformation of adhesions and the location of adhesions at a second surgery. Results(s): Adhesions or adhesions combined with endometriotic lesions were significantly more likely to reform at second surgery compared with sites having only an endometriosis lesion. Thick adhesions were associated with a significantly increased likelihood of an adhesion reforming, compared with thin adhesions or thin and thick adhesions. Lesions or adhesions involving the ovary were more likely to be associated with adhesions at a subsequent surgery, compared with lesions in the adjacent ovarian fossa or fallopian tube. Conclusion(s): Most patients developed adhesions after radical surgical excision of endometriosis for pelvic pain. The high incidence of adhesion formation after surgery for endometriosis underscores the importance of optimizing surgical techniques to potentially reduce adhesion formation. C1 NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. NIH, Combined Fed Fellowship Reprod Endocrinol & Infer, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. Georgetown Univ, Med Ctr, Dept Obstet & Gynecol, Washington, DC 20057 USA. RP Stratton, P (reprint author), NICHHD, Reprod Biol & Med Branch, NIH, 10 Ctr Dr MSC1109,Bldg 10 CRC,Room 1-13140, Bethesda, MD 20892 USA. EM ps79c@nih.gov FU Intramural NIH HHS NR 26 TC 31 Z9 31 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD NOV PY 2005 VL 84 IS 5 BP 1457 EP 1461 DI 10.1016/j.fertnstert.2005.04.057 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 985GO UT WOS:000233365500028 PM 16275244 ER PT J AU King, GW Luchies, CW Stylianou, AP Schiffman, JM Thelen, DG AF King, GW Luchies, CW Stylianou, AP Schiffman, JM Thelen, DG TI Effects of step length on stepping responses used to arrest a forward fall SO GAIT & POSTURE LA English DT Article DE balance; motor control; step length; forward fall; human ID BALANCE RECOVERY; YOUNG; AGE; ADULTS; PERTURBATIONS; GENDER; MOTION AB This study investigated effects of step length on the stepping response used to arrest an impending forward fall. Twelve healthy young (mean age 22, S.D. 3.3 years) males participated by recovering balance with a single step following a forward lean-and-release. Participants were instructed to step to one of three floor targets representing small, natural, and large step lengths. The effect of step length was examined on the primary outcome variables: pushoff time, liftoff and landing time, swing duration, balance recovery time, landing impulse, and center of mass (COM) characteristics. Pushoff and liftoff times were not affected by step length, although swing phase duration, landing and recovery times and the anterior-posterior (AP) impulse at landing increased with increasing step length. The results support the idea of an invariant step preparation phase. Given that our participants naturally chose not to utilize a step as short as they were capable of employing, healthy young individuals do not minimize recovery time nor strength requirements when selecting their step length. (c) 2004 Elsevier B.V. All rights reserved. C1 Univ Kansas, Dept Mech Engn, Lawrence, KS 66045 USA. USA, Soldier Syst Ctr, Natick, MA 01760 USA. Univ Wisconsin, Dept Mech Engn, Madison, WI 53706 USA. RP Luchies, CW (reprint author), Univ Kansas, Dept Mech Engn, Lawrence, KS 66045 USA. EM luchies@ku.edu FU NIA NIH HHS [AG13759-01] NR 25 TC 15 Z9 15 U1 0 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 J9 GAIT POSTURE JI Gait Posture PD NOV PY 2005 VL 22 IS 3 BP 219 EP 224 DI 10.1016/j.gaitpost.2004.09.008 PG 6 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA 978JJ UT WOS:000232869100006 PM 16214661 ER PT J AU Dow, GS Caridha, D Goldberg, M Wolf, L Koenig, ML Yourick, DL Wang, ZN AF Dow, GS Caridha, D Goldberg, M Wolf, L Koenig, ML Yourick, DL Wang, ZN TI Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro SO GENOMICS LA English DT Article DE mefloquine; thapsigargin; microarrays; neurotoxicity; UPR; transcription factors ID UNFOLDED PROTEIN RESPONSE; ENDOPLASMIC-RETICULUM; SQUALENE SYNTHASE; STRESS-RESPONSE; CELL-LINE; PROSTATE-CANCER; P-GLYCOPROTEIN; RAT; INHIBITION; EXPRESSION AB Mefloquine is associated with adverse neurological effects that are mediated via unknown mechanisms. Recent in vitro studies have shown that mefloquine disrupts neuronal calcium homeostasis via liberation of the endoplasmic reticulum (ER) store and induction of calcium influx across the plasma membrane. In the present study, global changes in gene expression induced in neurons in response to mefloquine-induced disruption of calcium homeostasis and appropriate control agents were investigated in vitro using Affymetrix arrays. The mefloquine transcriptome was found to be enriched for important regulatory sequences of the unfolded protein response and the drug was also found to induce key ER stress proteins, albeit in a manner dissimilar to, and at higher equivalent concentrations than, known ER-tropic agents like thapsigargin. Mefloquine also down-regulated several important functional categories of genes, including transcripts encoding G proteins and ion channels. These effects may be related to intrusion of extracellular calcium since they were also observed after glutamatc, but not thapsigargin, hydrogen peroxide, or low-dose mefloquine treatment. Mefloquine could be successfully differentiated from other treatments on the basis of principle component analysis of its "calcium-relevant" transcriptome. These data may aid interpretation of expression of results from future in vivo studies. Published by Elsevier Inc. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Neurosci, Silver Spring, MD 20910 USA. Henry M Jackson Fdn Advancement Mil Med, Rockville, MD 20850 USA. RP Dow, GS (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM geoffrey.dow@na.amedd.army.mil RI Yourick, Debra/A-2121-2011 NR 54 TC 18 Z9 18 U1 1 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0888-7543 J9 GENOMICS JI Genomics PD NOV PY 2005 VL 86 IS 5 BP 539 EP 550 DI 10.1016/j.ygeno.2005.07.004 PG 12 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 978JR UT WOS:000232869900004 PM 16109470 ER PT J AU Parthasarathy, N DeShazer, D Barrais, R England, MJ Waag, DM AF Parthasarathy, N DeShazer, D Barrais, R England, MJ Waag, DM TI Polysaccharide microarrays for the diagnosis of bacterial infections SO GLYCOBIOLOGY LA English DT Meeting Abstract CT Meeting of the Society-for-Glycobiology CY NOV 09-12, 2005 CL Boston, MA SP Soc Glycobiol C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0959-6658 J9 GLYCOBIOLOGY JI Glycobiology PD NOV PY 2005 VL 15 IS 11 MA 161 BP 1226 EP 1226 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 979CP UT WOS:000232920300174 ER PT J AU Hodgson, W Kaplan, KJ Rodriguez, M McHale, MT Rose, GS Elkas, JC AF Hodgson, W Kaplan, KJ Rodriguez, M McHale, MT Rose, GS Elkas, JC TI The impact of converting to liquid-based cervical cytology in a military population SO GYNECOLOGIC ONCOLOGY LA English DT Article DE liquid-based cytology; unsatisfactory; squamous intraepithelial lesion; conventional cytology; atypical glandular cells; pap smear ID CONVENTIONAL PAPANICOLAOU SMEARS; ADEQUACY; SYSTEM; TRIAL AB Objective. The liquid-based cytology Pap test was adopted as the exclusive collection method for cervical cytology in military treatment facilities within the National Capital Area in 2001. We sought to determine the impact of converting from conventional to liquid-based cervical cytology. Methods. A retrospective population -based study was performed to analyze the cervical cytology results from the National Capital Area for fiscal years 1999, 2000, 2002, and 2003. Using a computer database, the results of 78,738 conventional and 76,675 liquid-based cervico-vaginal cytology examinations were reviewed. All cytology samples during the study period were collected with the same collection device and were processed in a single laboratory. Results. An increase of 116% (P < 0.005) in the mean rate of LSIL detection and a 38% (P < 0.005) increase ill HSIL detection were noted with conversion to liquid-based cytology. A 65% (P < 0.005) decrease in the mean rate of atypical glandular cell detection was also observed. However, a mean increase of 46% (P < 0.005) per year was noted in the unsatisfactory rate with conversion to liquid-based cytology. The incidence of cervical carcinoma did not change during the study period. Conclusions. Consistent with previous reports, conversion front conventional to liquid-based Pap testing ill this Population resulted in a significant increase in the detection rates of both LSIL and HSIL. Contrary to earlier studies, we noted an almost 50% increase in the number of unsatisfactory samples after conversion. Further studies are warranted to determine the potential etiology of these findings to include the role of collection devices. Published by Elsevier Inc. C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. USN Hosp, Dept Obstet & Gynecol, Div Gynecol Oncol, San Diego, CA 92134 USA. RP Elkas, JC (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM john.elka@na.amedd.army.mil NR 21 TC 3 Z9 4 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 2005 VL 99 IS 2 BP 422 EP 426 DI 10.1016/j.ygyno.2005.06.046 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 981YO UT WOS:000233124100029 PM 16109441 ER PT J AU Goans, RE Waselenko, JK AF Goans, RE Waselenko, JK TI Medical management of radiological casualties SO HEALTH PHYSICS LA English DT Article; Proceedings Paper CT 40th Annual Meeting of the National-Council-on-Radiation-Protection-and-Measurements CY APR 14-15, 2004 CL Arlington, VA SP Natl Council Radiat Protect & Measurements DE National Council on Radiation Protection and Measurements; emergencies; radiological; terrorism; health effects ID NEUTROPENIC CANCER-PATIENTS; COLONY-STIMULATING FACTOR; TOTAL-BODY IRRADIATION; FUNGAL-INFECTIONS; FLUCONAZOLE PROPHYLAXIS; MARROW TRANSPLANTATION; HEMATOPOIETIC RECOVERY; QUINOLONE THERAPY; CONTROLLED TRIAL; DOUBLE-BLIND AB Victims of radiological terrorism events require prompt diagnosis and treatment of medical and surgical conditions as well as conditions related to radiation exposure. Hospital emergency personnel should triage victims using traditional medical and trauma criteria. Radiation dose can be estimated early post-event using rapid-sort, automated biodosimetry and clinical parameters such as the clinical history, the time to emesis (TE), and lymphocyte depletion kinetics. For TE < 2 h, the effective whole-body dose is at least 3 Gy. If TE < 1 h, the whole-body dose most probably exceeds 4 Gy. Lymphocyte depletion follows dose-dependent, first order kinetics after high-level gamma and criticality incidents. Patient radiation dose can be estimated very effectively from the medical history, serial lymphocyte counts, and TE, and subsequently confirmed with chromosome-aberration bioassay, the current gold standard. These data are effectively analyzed using the Armed Forces Radiobiology Research Institute Bio-dosimetry Assessment Tool. The medical management of patients with acute, moderate to severe radiation exposure (effective whole-body dose > 3 Gy) should emphasize the rapid administration of colony stimulating factors. All of these compounds decrease the duration of radiation-induced neutropenia and stimulate neutrophil recovery, albeit with some variability, in patients who have received myelotoxic chemotherapy, and all have demonstrated benefit in irradiated animals. For those patients developing febrile radiation-induced neutropenia, adherence to the current Infectious Diseases Society of America guidelines for high-risk neutropenia is recommended. C1 MJW Corp, Clinton, TN 37716 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Goans, RE (reprint author), MJW Corp, 1422 Eagle Bend Dr, Clinton, TN 37716 USA. EM ronald.goans@comcast.net NR 38 TC 36 Z9 38 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD NOV PY 2005 VL 89 IS 5 BP 505 EP 512 DI 10.1097/01.HP.0000172144.94491.84 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 973KI UT WOS:000232521000011 PM 16217194 ER PT J AU Wolbarst, AB Biwer, BM Cady, R Chen, SY Domotor, S Egidi, P LePoire, DJ Mo, T Peterson, J Walker, S AF Wolbarst, AB Biwer, BM Cady, R Chen, SY Domotor, S Egidi, P LePoire, DJ Mo, T Peterson, J Walker, S TI ISCORS catalog of references to parameter values and distributions used in environmental pathway modeling for cleanup of sites contaminated with radioactivity SO HEALTH PHYSICS LA English DT Article DE operational topic; peer review; safety standards; computers AB Sites Contaminated with Radioactivity is a web-based, indexed compilation of references, compendia, databases, and other sources of peer-reviewed information on parameters. It does not itself contain numerical point values or distributions for any particular parameter, but rather it provides links or directions to sites or other published materials where such information can be obtained. Designed to be user-friendly, easily searchable, and readily up-dateable, the Catalog is being filled, after some initial priming, mainly through on-line submissions of proposed references by the Catalog users themselves. The relevant information on a proposed reference is submitted to ISCORS in a simple, standardized formal; it is vetted (with acceptance criteria such as publication in a peer-reviewed technical journal, or appearance in a formally-issued federal agency report) and then added semi-automatically to the Catalog. Built around a relational database, the system offers subject- and text-search capabilities, provides information on parameter definitions and methods of measurement, on transport/exposure pathways, and on standard models and codes. The Catalog is intended for use by (and being populated by) the professionals, managers, and others involved or interested in the application of pathway modeling to estimate doses and risks associated with sites contaminated with radioactive or other hazardous materials. C1 US EPA, Washington, DC 20460 USA. Argonne Natl Lab, Argonne, IL 60439 USA. US Nucl Regulatory Commiss, Washington, DC 20555 USA. US DOE, Washington, DC 20402 USA. Colorado Dept Publ Hlth & Environm, Denver, CO 80246 USA. USA Corps Engineers, Omaha, NE 68144 USA. RP Wolbarst, AB (reprint author), US EPA, Washington, DC 20460 USA. NR 43 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD NOV PY 2005 VL 89 IS 5 SU S BP S91 EP S99 DI 10.1097/01.HP.0000177683.93443.f4 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 974PL UT WOS:000232603800009 PM 16224267 ER PT J AU Kim, YK Danner, AJ Raftery, JJ Choquette, KD AF Kim, YK Danner, AJ Raftery, JJ Choquette, KD TI Focused ion beam nanopatterning for optoelectronic device fabrication SO IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS LA English DT Article DE focused ion beam (FIB); lithography; photonic crystal; vertical cavity surface-emitting laser (VCSEL) ID SURFACE-EMITTING LASERS; HIGH-RESOLUTION; PHOTONIC CRYSTALS; CONTINUOUS RELIEF; SELECTIVE GROWTH; MODE; LITHOGRAPHY; SYSTEM; NANOLITHOGRAPHY; IMPLANTATION AB Recent photonic device structures, including distributed Bragg reflectors (DBRs), one-dimensional (1-D) or two-dimensional (2-D) photonic crystals, and surface plasmon devices, often require nanoscale lithography techniques for their device fabrication. Focused ion beam (FIB) etching has been used as a nanolithographic tool for the creation of these nanostructures. We report the use of FIB etching as a lithographic tool that enables sub-100-nm resolution. The FIB patterning of nanoscale holes on an epitaxially grown GaAs layer is characterized. To eliminate re-deposition of sputtered materials during FIB patterning, we have developed a process using a dielectric mask and subsequent dry etching. This approach creates patterns with vertical and smooth sidewalls. A thin titanium layer can be deposited on the dielectric layer to avoid surface charging effects during the FIB process. This FIB nanopatterning technique can be applied to fabricate optoelectronic devices, and we show examples of 1-D gratings in optical fibers for sensing applications, photonic crystal vertical cavity lasers, and photonic crystal defect lasers. C1 Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA. Agilent Technol, Singapore, Singapore. US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. RP Kim, YK (reprint author), Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA. EM choquett@uiuc.edu NR 48 TC 48 Z9 48 U1 1 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1077-260X J9 IEEE J SEL TOP QUANT JI IEEE J. Sel. Top. Quantum Electron. PD NOV-DEC PY 2005 VL 11 IS 6 BP 1292 EP 1298 DI 10.1109/JSTQE.2005.859022 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 009WL UT WOS:000235144100007 ER PT J AU Conti, G Ahamad, M AF Conti, G Ahamad, M TI A framework for countering denial-of-information attacks SO IEEE SECURITY & PRIVACY LA English DT Article C1 US Mil Acad, West Point, NY 10996 USA. Georgia Inst Technol, Atlanta, GA 30332 USA. RP Conti, G (reprint author), US Mil Acad, West Point, NY 10996 USA. EM conti@acm.org; mustaq@cc.gatech.edu NR 4 TC 3 Z9 3 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD NOV-DEC PY 2005 VL 3 IS 6 BP 50 EP 56 DI 10.1109/MSP.2005.140 PG 7 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 990WA UT WOS:000233772700010 ER PT J AU Power, EM Trope, RL AF Power, EM Trope, RL TI Acting responsibly with geospatial data SO IEEE SECURITY & PRIVACY LA English DT Article C1 Lafleur Henderson LLP, Ottawa, ON, Canada. US Mil Acad, Dept Law, West Point, NY 10996 USA. RP Power, EM (reprint author), Lafleur Henderson LLP, Ottawa, ON, Canada. EM michael.power@gowlings.com; trope@verizon.net NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD NOV-DEC PY 2005 VL 3 IS 6 BP 77 EP 80 DI 10.1109/MSP.2005.141 PG 4 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 990WA UT WOS:000233772700015 ER PT J AU Sun, KL O'Neill, K Shubitidze, F Shamatava, I Paulsen, KD AF Sun, KL O'Neill, K Shubitidze, F Shamatava, I Paulsen, KD TI Fast data-derived fundamental spheroidal excitation models with application to UXO discrimination SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE electromagnetic induction (EMI); fundamental excitation modes; ill-conditioning; inversion; pattern matching; spheroid; unexploded ordnance (UXO) AB Current idealized forward models for electromagnetic induction (EMI) response can be defeated by the characteristic material and geometrical heterogeneity of realistic unexploded ordnance (UXO). A new, physically complete modeling system was developed that includes all effects of these heterogeneities and their interactions within the object, in both near and far fields. The model is fast enough for implementation in inversion processing algorithms. A method is demonstrated for extracting the model parameters by straightforward processing of data from a defined measurement protocol. Depending on the EMI sensor used for measurements, the process of inferring model parameters is more or less ill-posed. More complete data can alleviate the problem. For a given set of data, special numerical treatment is introduced to take the best advantage of the data and obtain reliable model parameters. The resulting fast model is implemented in a pattern matching treatment of measurements by which signals from a UXO are identified within a series of those from unknown targets. Preliminary results show that this fast model is promising for use in processing of this kind. The inherent difficulties of target identification are examined, and solutions for resolving these difficulties are discussed. C1 Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Sun, KL (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM Keli.sun@dartmouth.edu NR 20 TC 26 Z9 26 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD NOV PY 2005 VL 43 IS 11 BP 2573 EP 2583 DI 10.1109/TGRS.2005.857327 PG 11 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 979KU UT WOS:000232941700017 ER PT J AU Collier, SL AF Collier, SL TI Fisher information for a complex Gaussian random variable: Beamforming applications for wave propagation in a random medium SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE angle of arrival; atmospheric effects; complex Gaussian; Cramer-Rao lower bound; estimation; Fisher information; inhomogeneous media; outdoor sound propagation; performance bounds; random media; sound propagation ID DIRECTION-OF-ARRIVAL; IMPERFECT SPATIAL COHERENCE; PERFORMANCE BOUNDS; SENSOR ARRAYS; TURBULENT MEDIUM; ANGLE ESTIMATION; SIGNAL; AMPLITUDE; LOCALIZATION; PARAMETERS AB We derive a general expression for the Fisher information for a special class of complex Gaussian random variables, whose mean and covariance may be expressed in terms of a specific parameterized linear transformation. The deterministic unknown parameter case is considered. This class is descriptive of signals that propagate in a homogeneous or inhomogeneous medium and also occurs in numerous beamforming applications. The Fisher information derived here encompasses a wide range of previously derived, well-known results for complex Gaussian signals propagating in a homogeneous medium and is also applicable to more recent models for signals propagating in an inhomogenous medium. The conditions for the estimates of the azimuth and elevation to decouple from the estimates of the nuisance parameters are studied for monochromatic plane-wave and spherical-wave propagation in a random medium. For propagation in an anisotropic medium, it is found that, in general, the Cramer-Rao lower bounds (CRLBs) of the entire unknown parameter set will be coupled. For special cases of propagation in an isotropic medium, it is found that for plane waves, the CRLBs of the angles of arrival will be approximately decoupled from the CRLBs of the other unknowns, and for spherical waves, the CRLBs of the angles of arrival will be always be coupled to the CRLBs of all other unknowns, although the couplings may be minimized under certain conditions. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Collier, SL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM scollier@arl.army.mil NR 35 TC 9 Z9 9 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD NOV PY 2005 VL 53 IS 11 BP 4236 EP 4248 DI 10.1109/TSP.2005.857046 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 977YH UT WOS:000232838900017 ER PT J AU Salberg, AB Swami, A AF Salberg, AB Swami, A TI Doppler and frequency-offset synchronization in wideband OFDM SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE Doppler effects; estimation of signal parameters via rotational invariance techniques (ESPRIT); orthogonal frequency-division multiplexing (OFDM); synchronization; under-water acoustics; wideband ID OPTIMUM RECEIVER DESIGN; TRANSMISSION; PARAMETERS; SYSTEMS; ESPRIT; BLIND AB When the orthogonal frequency-division multiplexing (OFDM) signal is appreciably wideband, as in underwater communications, a single Doppler-shift parameter is inadequate to model the Doppler effect, and a rate parameter is required as well. Such a model also accommodates nonsynchronized sampling of the received signal. We establish conditions for the identifiability of the Doppler parameters, and show how they affect the placement of null subcarriers (NSC). We derive the maximum-likelihood (ML) estimator and the corresponding conditional Cramer-Rao lower bound. We show that the vector formulation is amenable to estimation of signal parameters via rotational invariance techniques (ESPRIT) analysis, leading to a suboptimal but closed-form estimator. If the rate parameter is left uncompensated, we establish that the effective SNR is drastically reduced, which further leads to an increased bit error rate (BER). The ML estimator is demonstrated by numerical simulations that show that the performance of the estimator approaches the Cramer-Rao lower bound in the moderate-to-high SNR regions. C1 Inst Marine Res, NO-9294 Tromso, Norway. US Army Res Lab, Adelphi, MD 20784 USA. RP Salberg, AB (reprint author), Inst Marine Res, NO-9294 Tromso, Norway. EM arntbs@ieee.no; a.swami@ieee.org NR 24 TC 23 Z9 25 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD NOV PY 2005 VL 4 IS 6 BP 2870 EP 2881 DI 10.1109/TWC.2005.858337 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 991AF UT WOS:000233783800029 ER PT J AU Liu, XQ Sidiropoulos, ND Swami, A AF Liu, XQ Sidiropoulos, ND Swami, A TI Joint hop timing and frequency estimation for collision resolution in FH networks SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE collision resolution; frequency hopping; harmonic retrieval (HR); multiuser detection; timing estimation ID STATISTICAL-MODEL; SIGNALS; ESPRIT; ARRAY; INTERFERENCE; CHANNELS; SYSTEMS; ANGLE; CDMA; RANK AB With the rapid growth of frequency-hopped (FH) wireless networks, interference due to frequency collisions has become one of the main performance-limiting challenges. This paper proposes a novel multiuser detection method for joint hop timing and frequency estimation, which is capable of unraveling and demodulating multiple FH transmissions in the presence of collisions and unknown hop patterns without retransmission. The method is based on the principle of dynamic programming (DP) coupled with two-dimensional harmonic retrieval (2-D HR) or low-rank trilinear decomposition, and it remains operational even with multiple unknown hop rates, frequency offsets, and asynchronism. The model is based on frequency-shift keying (FSK) and phase-shift keying (PSK) modulation, but the algorithms are also evaluated with Gaussian minimum-shift keying (GMSK) modulation and shown to be robust. C1 Univ Louisville, Dept Elect & Comp Engn, Louisville, KY 40292 USA. Tech Univ Ctete, Dept Elect & Comp Engn, Khania 73100, Crete, Greece. Army Res Lab, AMSRD, ARL CI CN, Adelphi, MD 20783 USA. RP Liu, XQ (reprint author), Univ Louisville, Dept Elect & Comp Engn, Louisville, KY 40292 USA. EM x.liu@louisville.edu; nikos@telecom.tuc.gr; a.swami@ieee.org NR 32 TC 15 Z9 21 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD NOV PY 2005 VL 4 IS 6 BP 3063 EP 3074 DI 10.1109/TWC.2005.858006 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 991AF UT WOS:000233783800046 ER PT J AU Druar, C Saini, SS Cossitt, MA Yu, F Qiu, XG Geisbert, TW Jones, S Jahrling, PB Stewart, DIH Wiersma, EJ AF Druar, C Saini, SS Cossitt, MA Yu, F Qiu, XG Geisbert, TW Jones, S Jahrling, PB Stewart, DIH Wiersma, EJ TI Analysis of the expressed heavy chain variable-region genes of Macaca fascicularis and isolation of monoclonal antibodies specific for the Ebola virus' soluble glycoprotein SO IMMUNOGENETICS LA English DT Article DE antibody repertoire; cynomolgus monkey; V-H gene; monoclonal antibody; ebola virus ID V-H; B-CELLS; HYPERVARIABLE REGIONS; SOMATIC HYPERMUTATION; GERMLINE REPERTOIRE; RHESUS-MONKEYS; MACAQUE; EVOLUTION; SEQUENCE; PHAGE AB The cynomolgus macaque, Macaca fascicularis, is frequently used in immunological and other biomedical research as a model for man; understanding it's antibody repertoire is, therefore, of fundamental interest. The expressed variable-region gene repertoire of a single M. fascicularis, which was immune to the Ebola virus, was studied. Using 5' rapid amplification of cDNA ends with immunoglobulin (Ig)G-specific primers, we obtained 30 clones encoding full-length variable, diversity, and joining domains. Similar to the human V-H repertoire, the M. fascicularis repertoire utilized numerous immunoglobulin heavy variable (IGHV) gene fragments, with the V(H)3 (41%), V(H)4 (39%), and V(H)1 (14%) subgroups used more frequently than the V(H)5 (3.9%) or V(H)7 (1.7%) subgroups. Diverse immunoglobulin heavy joining (IGHJ) fragments also appeared to be utilized, including a putative homolog of JH5 beta gene segment identified in the related species Macaca mulatta, Rhesus macaque, but not in humans. Although the diverse V region genes in the IgG antibody repertoire of M. fascicularis had likely undergone somatic hypermutations (SHMs), they nevertheless showed high nucleotide identity with the corresponding human germline genes, 80-89% for IGHV and 72-92% for IGHJ. M. fascicularis and human V-H genes were also similar in other aspects: length of complementarity-determining regions and framework regions, and distribution of consensus sites for SHMs. Finally, we demonstrated that monoclonal antibodies (mAbs) specific for an Ebola protein could be obtained from M. fascicularis tissue samples by phage display technology. In summary, the study provides new insight into the M. fascicularis V region gene repertoire and further supports the idea that macaque-derived mAbs may be of therapeutic value to humans. C1 Cangene Corp, Mississauga, ON L4V 1T4, Canada. Canadian Food Inspect Agcy, Beamsville, ON L0R 1B2, Canada. Hlth Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Wiersma, EJ (reprint author), Cangene Corp, 3404 Amer Dr, Mississauga, ON L4V 1T4, Canada. EM ewiersma@cangene.com NR 46 TC 10 Z9 10 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0093-7711 J9 IMMUNOGENETICS JI Immunogenetics PD NOV PY 2005 VL 57 IS 10 BP 730 EP 738 DI 10.1007/s00251-005-0047-4 PG 9 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA 983NO UT WOS:000233239500003 PM 16215733 ER PT J AU Arakawa, T Komesu, A Otsuki, H Sattabongkot, J Udomsangpetch, R Matsumoto, Y Tsuji, N Wu, YM Torii, M Tsuboi, T AF Arakawa, T Komesu, A Otsuki, H Sattabongkot, J Udomsangpetch, R Matsumoto, Y Tsuji, N Wu, YM Torii, M Tsuboi, T TI Nasal immunization with a malaria transmission-blocking vaccine candidate, Pfs25, induces complete protective immunity in mice against field isolates of Plasmodium falciparum SO INFECTION AND IMMUNITY LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; CHOLERA-TOXIN; INTRANASAL IMMUNIZATION; ANTIBODIES; IMMUNOGENICITY; INDUCTION; ANTIGEN; VIVAX; DNA; EXPRESSION AB Malaria transmission-blocking vaccines based on antigens expressed in sexual stages of the parasites are considered one promising strategy for malaria control. To investigate the feasibility of developing noninvasive mucosal transmission-blocking vaccines against Plasmodium falciparum, intranasal immunization experiments with Pichia pastoris-expressed recombinant Pfs25 proteins were conducted. Mice intranasally immunized with the Pfs25 proteins in the presence of a potent mucosal adjuvant cholera toxin induced robust systemic as well as mucosal antibodies. All mouse immunoglobulin G (IgG) subclasses except IgG3 were found in serum at comparable levels, suggesting that the immunization induced mixed Th1 and Th2 responses. Consistent with the expression patterns of the Pfs25 proteins in the parasites, the induced immune sera specifically recognized ookinetes but not gametocytes. In addition, the immune sera recognized Pfs25 proteins with the native conformation but not the denatured forms, indicating that mucosal immunization induced biologically active antibodies capable of recognizing conformational epitopes of native Pfs25 proteins. Feeding Anopheles dirus mosquitoes with a mixture of the mouse immune sera and gametocytemic blood derived from patients infected with P. falciparum resulted in complete interference with oocyst development in mosquito midguts. The observed transmission-blocking activities were strongly correlated with specific serum antibody titers. Our results demonstrated for the first time that a P. falciparum transmission-blocking vaccine candidate is effective against field-isolated parasites and may justify the investigation of noninvasive mucosal vaccination regimens for control of malaria, it prototypical mucosa-unrelated mosquito-borne parasitic disease. C1 Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. Univ Ryukyus, Ctr Mol Biosci, Div Mol Microbiol, Nishihara, Okinawa 9030213, Japan. Ehime Univ, Sch Med, Dept Mol Parasitol, Toon, Ehime 7910295, Japan. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. Univ Tokyo, Grad Sch Agr & Life Sci, Lab Global Anim Resource Sci, Bunkyo Ku, Tokyo 1138657, Japan. Natl Agr Res Org, Natl Inst Anim Hlth, Parasit Dis Lab, Tsukuba, Ibaraki 3050856, Japan. NIAID, Malaria Vaccine Dev Branch, NIH, Rockville, MD 20852 USA. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, 3 Bunkyo Cho, Matsuyama, Ehime 7908577, Japan. EM tsuboi@ccr.ehime-u.ac.jp NR 33 TC 47 Z9 50 U1 8 U2 28 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 2005 VL 73 IS 11 BP 7375 EP 7380 DI 10.1128/IAI.73.11.7375-7380.2005 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 977WI UT WOS:000232833800036 PM 16239536 ER PT J AU Hawley, JS Hospenthal, DR AF Hawley, JS Hospenthal, DR TI Fungal infections of the CNS - Part 1: Meningitis SO INFECTIONS IN MEDICINE LA English DT Article DE meningitis; CNS infection; mycoses; fungus ID PRACTICE GUIDELINES; CRYPTOCOCCUS-NEOFORMANS; MANAGEMENT; THERAPY; DISEASE C1 Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Hawley, JS (reprint author), Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU SCP COMMUNICATIONS INC PI NEW YORK PA 134 W 29TH ST, NEW YORK, NY 10001-5304 USA SN 0749-6524 J9 INFECT MED JI Infect. Med. PD NOV PY 2005 VL 22 IS 11 BP 573 EP 576 PG 4 WC Infectious Diseases SC Infectious Diseases GA 989GA UT WOS:000233659700010 ER PT J AU de Rosset, WS AF de Rosset, WS TI Patterned armor performance evaluation SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE patterned armor; armor performance evaluation; limit velocity; ceramic armor; multiple-hit criterion; lightweight armor; multiple-hit capability AB Patterned armor is characterized by an array of repeating cells, such as tiled ceramic armor or reactive armor boxes. Performance characteristics of an ideal patterned armor with respect to multiple hits are discussed, and the types of single-shot ballistic data needed to quantify that performance are presented. An approach to use these data is developed to provide a quantitative measure (probability of nonperforation after a given number of impacts) of the patterned armor performance against multiple impacts. This performance measure can then be compared to a well-posed multiple-hit criterion to assess whether the patterned armor meets the criterion. (c) 2004 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP de Rosset, WS (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 5 TC 9 Z9 9 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD NOV PY 2005 VL 31 IS 10 BP 1223 EP 1234 DI 10.1016/j.ijimpeng.2004.07.009 PG 12 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 938ED UT WOS:000229981800002 ER PT J AU Evans, AK Licameli, G Brietzke, S Whittemore, K Kenna, M AF Evans, AK Licameli, G Brietzke, S Whittemore, K Kenna, M TI Pediatric facial nerve paralysis: Patients, management and outcomes SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Article DE facial nerve paralysis; Bell's palsy; otitis media; temporal bone; pediatric ID ACUTE OTITIS-MEDIA; CHILDREN AB Objective: To characterize the causes and treatment of facial nerve paresis (FNP) in pediatric patients. Method: Retrospective study in a tertiary care pediatric hospital. Thirty-four patients identified with partial or complete FNP evaluated between 1997 and 2003. A review of the medical records including sex, age, laterality, etiology, therapy, severity of paralysis according to House-Brackman (HB) six-point grading scale, duration, and degree of recovery. Results: Thirty-five cases of FNP. Causes of FNP were infectious (13), traumatic (7), iatrogenic (5), congenital (4), Bell's/Idiopathic (3), relapsing (2) and neoplastic (1). Peak age distributions for both infectious and traumatic etiologies were bimodal: 1-3 and 8-12 years. Of the 13 infectious cases, 11 were associated with acute otitis media with effusion (AOME). Four (4/11) were bacterial-culture negative. Seven (7/11) were bacterial-culture positive, four (4/7) of which required prolonged, broth-medium culture. Bacteria cultured predominantly included Staphylococcus non-aureus species (5/7) and Propionobacterium acnes (3/7). One (1/13) was viral culture positive (Herpes Simplex Virus). All six patients who received intravenous steroids for OME-associated FNP received the doses within the first week of presentation and had complete recovery (HBI/VI); three of five patients who did not receive steroids had complete recovery. There were five iatrogenic cases; two (2/5) were planned surgical sacrifices and three (3/5) were complications of middle ear/mastoid surgery. Facial nerve function associated with infection returned in 0.5-2 months while, when associated with trauma, returned in 0.25-30 months. Conclusions: In infectious or traumatic FNP, children aged 1-3 and 8-12 years are the primary groups involved. In AOME FNP, culture-identified organisms may not be representative of traditional pathogens. Infectious FNP averaged 1 month for recovery while traumatic FNP averaged 9 months. Intravenous steroid therapy may improve the outcome. Recovery was complete (HBI/VI) in 8/10 infectious and 4/6 traumatic cases. (c) 2005 Elsevier Ireland Ltd. All rights reserved. C1 Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02214 USA. Childrens Hosp, Dept Otolaryngol & Commun Disorders, Boston, MA 02215 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Rochester, Sch Med, Dept Otolaryngol, Rochester, NY 14618 USA. RP Evans, AK (reprint author), Harvard Univ, Sch Med, Dept Otol & Laryngol, 243 Charles St, Boston, MA 02214 USA. EM adeleyarrington@rcn.com; greg.licameti@childrens.harvard.edu; SBrietzke@aol.com; Kenneth_Whittemore@umc.rochester.edu; margaret.kenna@childrens.harvard.edu NR 8 TC 40 Z9 41 U1 2 U2 7 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0165-5876 J9 INT J PEDIATR OTORHI JI Int. J. Pediatr. Otorhinolaryngol. PD NOV PY 2005 VL 69 IS 11 BP 1521 EP 1528 DI 10.1016/j.ijporl.2005.04.025 PG 8 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA 981OU UT WOS:000233098700010 PM 15985298 ER PT J AU Reddy, G Erexson, GL Cifone, MA Major, MA Leach, GJ AF Reddy, G Erexson, GL Cifone, MA Major, MA Leach, GJ TI Genotoxicity assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE genotoxicity; hexahydro-1,3,5-trinitro-1,3,5-triazine; micronucleus assay; mouse lymphoma assay; RDX ID MAMMALIAN-CELLS; RISK-ASSESSMENT; MUTAGENICITY; MUNITIONS AB Hexahydro-1,3,5-trinitro-1,3,5-triazine, a polynitramine compound, commonly known as RDX, has been used as an explosive in military munitions formulations since World War II. There is considerable data available regarding the toxicity and carcinogenicity of RDX. It has been classified as a possible carcinogen (U.S. Environmental Protection Agency, Integrated Risk Information System, 2005, www.epa.gov/IRIS/subst/0313.htm). In order to better understand its gentoxic potential, the authors conducted the in vitro mouse lymphoma forward mutation and the in vivo mouse bone marrow micronucleus assays. Pure RDX (99.99%) at concentrations ranging from 3.93 to 500 mu g/ml showed no cytotoxicity and no mutagenicity in forward mutations at the thymidine kinase (TK) locus in L5178Y mouse lymphoma cells, with and without metabolic activation. This finding was also confirmed by repeat assays under identical conditions. In addition, RDX did not induce micronuclei in mouse bone marrow cells when tested to the maximum tolerated dose of 250 mg/kg in male mice. These results show that RDX was not mutagenic in these in vitro and in vivo mammalian systems. C1 US Army Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. Covance Labs Inc, Vienna, Austria. RP Reddy, G (reprint author), US Army Ctr Hlth Promot & Prevent Med, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gunda.reddy@us.army.mil NR 31 TC 9 Z9 9 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD NOV-DEC PY 2005 VL 24 IS 6 BP 427 EP 434 DI 10.1080/10915810500366922 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 998ZH UT WOS:000234357900005 PM 16393935 ER PT J AU Reddy, G Major, MA Leach, GJ AF Reddy, G Major, MA Leach, GJ TI Toxicity assessment of thiodiglycol SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE biochemical effects; environmental fate; genotoxicity; metabolism; RfD; thiodiglycol; toxicity ID BETA-LYASE METABOLITES; SULFUR MUSTARD; HYDROLYSIS PRODUCTS; BIOLOGICAL FATE; ETHYLENE-GLYCOL; DEVELOPMENTAL TOXICITY; ALLEGED ATTACK; GAS; IDENTIFICATION; URINE AB Sulfur mustard (HD) undergoes hydrolysis to form various products such as thiodiglycol (TG) in biological and environmental systems. TG is a precursor in the production of HD and it is also considered as a "Schedule 2" compound (dual-use chemicals with low to moderate commercial use and high-risk precursors). Several toxicological studies on TG were conducted to assess environmental and health effects. The oral LD50 values were >5000 mg/kg in rats. It was a mild skin and moderate ocular irritant and was not a skin sensitizer in animals. It was not mutagenic in Ames Salmonella, Escherichia coli, mouse lymphoma, and in vivo mouse micronucleus assays, but it induced chromosomal aberrations in Chinese hamster ovarian (CHO) cells. A 90-day oral subchronic toxicity study with neat TG at doses of 0, 50, 500, and 5000 mg/kg/day (5 days/week) in Sprague-Dawley rats results show that there are no treatment-related changes in food consumption, hematology, and clinical chemistry in rats of either sex. The body weights of both sexes were significantly lower than controls at 5000 mg/kg/day. Significant changes were also noted in both sexes in absolute weights of kidneys, kidney to body weight ratios, and kidney to brain weight ratios, in the high-dose group. The no-observed-adverse-effect level (NOAEL) for oral toxicity was 500 mg/kg/day. The developmental toxicity conducted at 0, 430, 1290, and 3870 mg/kg by oral gavage showed maternal toxicity in dams receiving 3870 mg/kg. TG was not a developmental toxicant. The NOAEL for the developmental toxicity in rats was 1290 mg/kg. The provisional oral reference dose (RfD) of 0.4 mg/kg/day was calculated for health risk assessments. The fate of TG in the environment and soil showed biological formation of thiodiglycalic acid with formation of an intermediate ((2-hydroxyethyl)thio)acetic acid. It was slowly biodegraded under anaerobic conditions. It was not toxic to bluegill sunfish at 1000 mg/L and its metabolism and environmental and biochemical effects are summarized. C1 US Army Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Reddy, G (reprint author), US Army Ctr Hlth Promot & Prevent Med, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gunda.reddy@us.army.mil NR 60 TC 10 Z9 10 U1 1 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD NOV-DEC PY 2005 VL 24 IS 6 BP 435 EP 442 DI 10.1080/10915810500368878 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 998ZH UT WOS:000234357900006 PM 16393936 ER PT J AU Cheuvront, SN Carter, R Castellani, JW Sawka, MN AF Cheuvront, SN Carter, R Castellani, JW Sawka, MN TI Hypohydration impairs endurance exercise performance in temperate but not cold air SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE dehydration; thermoregulation; environment ID SKIN TEMPERATURE; STROKE VOLUME; BLOOD-FLOW; HUMAN BODY; THERMOREGULATION; DEHYDRATION; HYPERTHERMIA; RELIABILITY; CAPACITY; MARATHON AB This study compared the effects of hypohydration (HYP) on endurance exercise performance in temperate and cold air environments. On four occasions, six men and two women (age = 24 +/- 6 yr, height = 170 +/- 6 cm, weight = 72.9 +/- 11.1 kg, peak O-2 consumption = 48 +/- 9 ml.kg(-1).min(-1)) were exposed to 3 h of passive heat stress (45 degrees C) in the early morning with [ euhydration (EUH)] or without (HYP; 3% body mass) fluid replacement. Later in the day, subjects sat in a cold (2 degrees C) or temperate (20 degrees C) environment with minimal clothing for 1 h before performing 30 min of cycle ergometry at 50% peak O-2 consumption followed immediately by a 30-min performance time trial. Rectal and mean skin temperatures, heart rate, and ratings of percieved exertion measurements were made at regular intervals. Performance was assessed by the total amount of work (kJ) completed in the 30-min time trial. Skin temperature was significantly lower in the cold compared with the temperate trial, but there was no independent effect of hydration. Rectal temperature in both HYP trials was higher than EUH after 60 min of exercise, but the difference was only significant within the temperate trials (P < 0.05). Heart rate was significantly higher at 30 min within the temperate trial (HYP > EUH) and at 60 min within the cold trial (HYP > EUH) (P < 0.05). Ratings of percieved exertion increased over time with no differences among trials. Total work performed during the 30-min time trial was not influenced by environment but was less (P < 0.05) for HYP than EUH in the temperate trials. The corresponding change in performance (EUH - HYP) was greater for temperate (-8%) than for cold (-3%) (P < 0.05). These data demonstrate that 1) HYP impairs endurance exercise performance in temperate but not cold air but 2) cold stress per se does not. C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM samuel.cheuvront@na.amedd.army.mil NR 33 TC 77 Z9 78 U1 3 U2 30 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD NOV PY 2005 VL 99 IS 5 BP 1972 EP 1976 DI 10.1152/japplphysiol.00329.2005 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 974QZ UT WOS:000232607800045 PM 16024524 ER PT J AU Sims, CS Drasgow, F Fitzgerald, LF AF Sims, CS Drasgow, F Fitzgerald, LF TI The effects of sexual harassment on turnover in the military: Time-dependent modeling SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article; Proceedings Paper CT 17th Annual Conference of the Society-for-Industrial-and-Organizational-Psychology CY APR 12-14, 2002 CL TORONTO, CANADA SP Soc Ind & Org Psychol DE sexual harassment; turnover; attrition; job attitudes ID VOLUNTARY EMPLOYEE TURNOVER; INTEGRATED MODEL; UNFOLDING MODEL; GENERAL ATTITUDES; ROLE-CONFLICT; JOB STRESS; OUTCOMES; CONSEQUENCES; WORK; ANTECEDENTS AB Sexual harassment has consistently negative consequences for working women, including changes in job attitudes (e.g., lower satisfaction) and behaviors (e.g., increased work withdrawal). Cross-sectional evidence suggests that harassment influences turnover intentions. However, few studies have used actual turnover; rather, they rely on proxies. With a sample of 11,521 military servicewomen with turnover data spanning approximately 4 years, the authors used the appropriate method for longitudinal turnover data-Cox's regression-to investigate the impact of harassment on actual turnover. Experiences of harassment led to increased turnover, even after controlling for job satisfaction, organizational commitment. and marital status. Among officers, harassment also affected turnover over and above rank. Given turnover's relevance to organizational bottom lines, these findings have important implications not only for individual women but also for organizations. C1 US Army Res Inst Behav & Social Sci, Arlington, VA 22202 USA. Univ Illinois, Urbana, IL 61801 USA. RP Sims, CS (reprint author), US Army Res Inst Behav & Social Sci, 2511 Jefferson Davis Highway, Arlington, VA 22202 USA. EM cssims@s.psych.uiuc.edu RI Drasgow, Fritz/F-7686-2011 FU NIMH NIH HHS [MH 050791-07] NR 54 TC 36 Z9 36 U1 0 U2 21 PU AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0021-9010 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD NOV PY 2005 VL 90 IS 6 BP 1141 EP 1152 DI 10.1037/0021-9010.90.6.1141 PG 12 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 987SH UT WOS:000233537100008 PM 16316270 ER PT J AU Pradhan, L Dabisch, PA Liles, JT Murthy, SN Baber, SR Simpson, SA Agrawal, KC Kadowitz, PJ AF Pradhan, L Dabisch, PA Liles, JT Murthy, SN Baber, SR Simpson, SA Agrawal, KC Kadowitz, PJ TI Effect of binge cocaine treatment on hindlimb vascular function SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE cocaine; binge; adrenergic; acetylcholine; nitric oxide; endothelin ID ARTERY ENDOTHELIAL-CELLS; HUMAN-PLATELET AGGREGATION; NITRIC-OXIDE; CORONARY-ARTERY; CARDIOVASCULAR COMPLICATIONS; INTRAVENOUS COCAINE; ACUTE TOLERANCE; CONSCIOUS DOGS; HEART-FAILURE; SMOOTH-MUSCLE AB Chronic cocaine abuse is known to cause endothelial dysfunction and atherosclerosis. The present study investigated the effect of binge cocaine treatment, a model for chronic cocaine abuse, on the blood flow responses to the adrenergic agonists norepinephrine, phenylephrine and isoproterenol, the endothelium-dependent vasodilator acetylcholine, and the endothelium independent vasodilator sodium nitroprusside (SNP) in the hindlimb vascular bed of male Sprague Dawley rats. Rats received either single binge or double binge treatment. Each binge treatment consisted of three doses of cocaine (30 mg kg(-1) i.p.) for 3 days. For double binge treatment, there was a 4 day recovery period between the binges. At the end of the treatment the rats were anesthetized and agonists were administered into the right hindlimb circulation through a catheter in the left iliac artery and blood flow responses were measured with a flow probe around the right iliac artery. Rats receiving double cocaine binges showed a significant decrease in the magnitude and duration of the blood flow response to norepinephrine and a decrease in the duration of the blood flow response to phenylephrine, isoproterenol and acetylcholine when compared with saline controls. The blood flow response to SNP was not changed. Total plasma nitrate-nitrite levels were significantly reduced and big endothelin levels were significantly increased in rats receiving double cocaine binges. This study demonstrates that binge cocaine treatment can alter endothelial function, while not changing smooth muscle function, and impairs the adrenergic pathway. Copyright (c) 2005 John Wiley & Sons, Ltd. C1 Tulane Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA. USA, Edgewood Chem Biol Ctr, Natl Res Council Postdoctoral Associate, Aberdeen Proving Ground, MD 21010 USA. RP Kadowitz, PJ (reprint author), Tulane Univ, Hlth Sci Ctr, Dept Pharmacol, SL83,1430 Tulane Ave, New Orleans, LA 70112 USA. EM pkadowi@tulane.edu FU NHLBI NIH HHS [R01-HL63128] NR 67 TC 10 Z9 10 U1 2 U2 3 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD NOV-DEC PY 2005 VL 25 IS 6 BP 479 EP 490 DI 10.1002/jat.1083 PG 12 WC Toxicology SC Toxicology GA 984LS UT WOS:000233307000006 PM 16092079 ER PT J AU Stevens, JM Ulrich, RL Taylor, LA Wood, MW DeShazer, D Stevens, MP Galyov, EE AF Stevens, JM Ulrich, RL Taylor, LA Wood, MW DeShazer, D Stevens, MP Galyov, EE TI Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant SO JOURNAL OF BACTERIOLOGY LA English DT Article ID ARP2/3 COMPLEX; WASP AB Recently we identified a bacterial factor (BimA) required for actin-based motility of Burkholderia pseudomallei. Here we report that Burkholderia mallei and Burkholderia thailandensis are capable of actin-based motility in J774.2 cells and that BimA homologs of these bacteria can restore the actin-based motility defect of a B. pseudomallei bimA mutant. While the BimA homologs differ in their amino-terminal sequence, they interact directly with actin in vitro and vary in their ability to bind Arp3. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM edouard.galyov@bbsrc.ac.uk FU Biotechnology and Biological Sciences Research Council [C20021, BBS/E/I/00001116] NR 19 TC 57 Z9 58 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD NOV PY 2005 VL 187 IS 22 BP 7857 EP 7862 DI 10.1128/JB.187.22.7857-7862.2005 PG 6 WC Microbiology SC Microbiology GA 985TA UT WOS:000233400200033 PM 16267310 ER PT J AU Curtin, BF Tetz, LM Compton, JR Doctor, BP Gordon, RK Nambiar, MP AF Curtin, BF Tetz, LM Compton, JR Doctor, BP Gordon, RK Nambiar, MP TI Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE acetylcholinesterase; organophosphates; transcriptional inducers; neuronal cell lines; gene expression; neuroprotection ID NERVE GROWTH-FACTOR; GENE-EXPRESSION; CYCLIC-AMP; MYOGENIC DIFFERENTIATION; NEURONAL DIFFERENTIATION; DEACETYLASE INHIBITORS; CELLULAR-LOCALIZATION; NEUROBLASTOMA-CELLS; MOLECULAR-FORMS; PRION PROTEIN AB The biological effects of organophosphorous (OP) chemical warfare nerve agents (CWNAs) are exerted by inhibition of acetylcholinesterase (ACH), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. Current investigations show that bioscavenger therapy using purified fetal bovine AChE in rodents and non-human primates and the more recently tested human butyrylcholinesterase, is a promising treatment for protection against multiple LD50 CWNA exposures. Potential impediments, due to the complex structure of the enzyme, purification effort, resources, and cost have necessitated alternative approaches. Therefore, we investigated the effects of transcriptional inducers to enhance the expression of AChE to achieve sufficient protection against OP poisoning. Trichostatin A (TSA), an inhibitor of histone deacetylase that de-condenses the chromatin, thereby increasing the binding of transcription factors and mRNA synthesis, was evaluated for induction of AChE expression in various neuronal cell lines. Dose-response curves showed that a concentration of 333 nM TSA was optimal in inducing AChE expression. In Neuro-2A cells, TSA at 333 nM increased the extracellular AChE activity approximately 3-4 fold and intracellular enzyme activity 10-fold. Correlating with the AChE induction, TSA pre-treatment significantly protected the cells against exposure to the organophosphate diisopropylfluorophosphate, a surrogate for the chemical warfare agents soman and sarin. These studies indicate that transcriptional inducers such as TSA up-regulate AChE, which then can bioscavenge any organophosphates present, thereby protecting the cells from OP-induced cytotoxicity. In conclusion, transcriptional inducers are prospective new methods to protect against CWNA exposure. C1 Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Madhusoodana.nambiar@na.amedd.army.mil NR 42 TC 8 Z9 8 U1 0 U2 11 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD NOV 1 PY 2005 VL 96 IS 4 BP 839 EP 849 DI 10.1002/jcb.20591 PG 11 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 978ES UT WOS:000232857000018 PM 16149071 ER PT J AU Katsiari, CG Kyttaris, VC Juang, YT Tsokos, GC AF Katsiari, CG Kyttaris, VC Juang, YT Tsokos, GC TI Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article AB Decreased IL-2 production in systemic lupus erythematosus (SLE) represents a central component of the disease immunopathology. We report that the message, protein, and enzymatic activity of the catalytic subunit of protein phosphatase 2A (PP2Ac), but not PP1, are increased in patients with SLE regardless of disease activity and treatment and in a disease-specific manner. Treatment of SLE T cells with PP2Ac-siRNA decreased the protein levels and activity of PP2Ac in a specific manner and increased the levels of phosphorylated cAMP response element-binding protein and its binding to the IL2 and c-fos promoters, as well as increased activator protein I activity, causing normalization of IL-2 production. Our data document increased activity of PP2A as a novel SLE disease-specific abnormality and define a distinct mechanism whereby it represses IL-2 production. We propose the use of PP2Ac-siRNA as a novel tool to correct T cell IL-2 production in SLE patients. C1 Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. Washington Hosp Ctr, Dept Med, Washington, DC 20010 USA. RP Tsokos, GC (reprint author), Walter Reed Army Inst Res, Dept Cellular Injury, Bldg 503,Room 1A32, Silver Spring, MD 20910 USA. EM gtsokos@usuhs.mil FU NIAID NIH HHS [R01 AI49954, R01 AI42269, R01 AI042269, R01 AI049954] NR 91 TC 66 Z9 71 U1 0 U2 3 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD NOV PY 2005 VL 115 IS 11 BP 3193 EP 3204 DI 10.1172/JCI24895 PG 12 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 980MH UT WOS:000233022100029 PM 16224536 ER PT J AU Patel, MM Belson, MG Longwater, AB Olson, KR Miller, MA AF Patel, MM Belson, MG Longwater, AB Olson, KR Miller, MA TI Methylenedioxymethamphetamine (ecstasy)-related hyperthermia SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE methylenedioxymethamphetamine; MDMA; hyperthermia; substance abuse ID 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; SEROTONIN SYNDROME; ECSTASY OVERDOSE; HYPERPYREXIA; TOXICITY; CYP2D6; PHARMACOLOGY; DEATHS AB MDMA (or 3, 4 methylenedioxymethamphetamine) was first manufactured in the 1920s and found to have structural similarities to both mescaline and amphetamines. Used briefly by some therapists in the 1970s and early 1980s as an adjunct to psychotherapy, it is now primarily abused by teenagers and young adults as an illicit recreational drug known as "ecstasy." As its popularity has increased, so have the number of fatalities and adverse events related to its use. We report six patients suffering fatal or life-threatening hyperthermia after MDMA use. These cases illustrate that hyperthermia associated with MDMA use cannot be solely attributed to rave parties (high ambient temperatures, excessive dancing, dehydration, and overcrowded conditions), drug contaminants, or co-ingestants. A better understanding of the etiology of hyperthermia after MDMA use is needed so that appropriate harm-reduction measures can be developed and instituted. (c) 2005 Elsevier Inc. C1 Georgia Poison Control Syst, Atlanta, GA USA. Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA 30322 USA. Univ Calif San Francisco, Sch Pharm, Calif Poison Control Syst, San Francisco, CA 94143 USA. USA, Darnall Community Hosp, Dept Emergency Med & Residency Program, Ft Hood, TX USA. RP Patel, MM (reprint author), 3661 Briarcliff, Atlanta, GA 30345 USA. NR 20 TC 23 Z9 23 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD NOV PY 2005 VL 29 IS 4 BP 451 EP 454 DI 10.1016/j.jemermed.2005.05.007 PG 4 WC Emergency Medicine SC Emergency Medicine GA 979QI UT WOS:000232959500016 PM 16243206 ER PT J AU Crocker, FH Thompson, KT Szecsody, JE Fredrickson, HL AF Crocker, FH Thompson, KT Szecsody, JE Fredrickson, HL TI Biotic and abiotic degradation of CL-20 and RDX in soils SO JOURNAL OF ENVIRONMENTAL QUALITY LA English DT Article ID EXPLOSIVE CL-20; GLYOXAL OXIDASE; BIODEGRADATION; BIOTRANSFORMATION; 2,4,6,8,10,12-HEXANITRO-2,4,6,8,10,12-HEXAAZAISOWURTZITANE; DECOMPOSITION; SEDIMENTS; INSIGHTS; SORPTION; FATE AB The caged cyclic nitramine 2,4,6,8,10,12-hexanitro-2,4,6,8,10,112-hexaazaisowurtzitane (CL-20) is a new explosive that has the potential to replace existing military explosives, but little is known about its environmental toxicity, transport, and fate. We quantified and compared the aerobic environmental fate of CL-20 to the widely used cyclic nitramine explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in surface and subsurface soil microcosms. Soil-free controls and biologically attenuated soil controls were used to separate abiotic processes from biologically mediated processes. Both abiotic and biological processes significantly degraded CL-20 in all soils examined. Apparent abiotic, first-order degradation rates (k) for CL-20 were not significantly different between soil-free controls (0.018 < k < 0.030 d(-1)) and biologically attenuated soil controls (0.003 < k < 0.277 d-1). The addition of glucose to biologically active soil microcosms significantly increased CL-20 degradation rates (0.068 < k < 1.22 d(-1)). Extents of mineralization of C-14-CL-20 to (CO2)-C-14 in biologically active soil microcosms were 41.1 to 55.7%, indicating that the CL-20 cage was broken, since all carbons are part of the heterocyclic cage. Under aerobic conditions, abiotic degradation rates of RDX were generally slower (0 < k < 0.032 d(-1)) than abiotic CL-20 degradation rates. In biologically active soil microcosms amended with glucose aerobic RDX degradation rates varied between 0.010 and 0.474 d(-1). Biodegradation was a key factor in determining the environmental fate of RDX, while a combination of biotic and abiotic processes was important with CL-20. Our data suggest that CL-20 should be less recalcitrant than RDX in aerobic soils. C1 Analyt Sci Inc, Vicksburg, MS 39180 USA. USA, Engineer Res & Dev Ctr, CEERD, EP, Vicksburg, MS 39180 USA. Pacific NW Natl Lab, Richland, WA 99354 USA. RP Crocker, FH (reprint author), Analyt Sci Inc, 3532 Manor Dr,Suite 3, Vicksburg, MS 39180 USA. EM Fiona.H.Crocker@erdc.usace.army.mil NR 35 TC 20 Z9 20 U1 1 U2 13 PU AMER SOC AGRONOMY PI MADISON PA 677 S SEGOE RD, MADISON, WI 53711 USA SN 0047-2425 J9 J ENVIRON QUAL JI J. Environ. Qual. PD NOV-DEC PY 2005 VL 34 IS 6 BP 2208 EP 2216 DI 10.2134/jeq2005.0032 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 984NL UT WOS:000233311500034 PM 16275722 ER PT J AU Conner, SJ Rideout, S AF Conner, SJ Rideout, S TI What are the best therapies for acute migraine in pregnancy? SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material ID HEADACHE; SUMATRIPTAN C1 Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA USA. E Carolina Univ, Greenville, NC USA. Baylor Coll Med, Dept Family Med, Houston, TX 77030 USA. RP Conner, SJ (reprint author), Dwight D Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU DOWDEN PUBLISHING CORP PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD NOV PY 2005 VL 54 IS 11 BP 992 EP + PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 985DV UT WOS:000233357300016 PM 16266607 ER PT J AU Massie, DD Boettner, DD Massie, CA AF Massie, DD Boettner, DD Massie, CA TI Residential experience with proton exchange membrane fuel cell systems for combined heat and power SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY LA English DT Article AB As part of a one-year Department of Defense demonstration project, proton exchange membrane fuel cell systems have been installed at three residences to provide electrical power and waste heat for domestic hot water and space heating. The 5 kW capacity fuel cells operate on reformed natural gas. These systems operate at preset levels providing power to the residence and to the utility, grid. During grid outages, the residential power source is disconnected from the grid and the fuel cell system operates in standby mode to provide power to critical loads in the residence. This paper describes lessons learned from installation and operation of these fuel cell systems in existing residences. Issues associated with installation of a fuel cell system for combined heat and power focus primarily on fuel cell siting, plumbing external to the fuel cell unit required to support heat recovery, and line connections between the fuel cell unit and the home interior for natural gas, water; electricity, and communications. Operational considerations of the fuel cell system are linked to heat recovery system design and conditions required for adequate flow of natural gas, air water and system communications. Based on actual experience with these systems in. a residential setting, proper system design, component installation, and sustainment of required flows are essential for the fuel cell system to provide reliable power and waste heat. C1 US Mil Acad, West Point, NY 10996 USA. Intelligent Power & Energy Res Corp, Ft Montgomery, NY 10922 USA. RP Massie, DD (reprint author), US Mil Acad, West Point, NY 10996 USA. EM Darrell.Massie@us.army.mil; Daisie.Boettner@us.army.mil; cheryl.massie@iperc.us NR 3 TC 3 Z9 4 U1 1 U2 1 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1550-624X J9 J FUEL CELL SCI TECH JI J. Fuel Cell Sci. Technol. PD NOV PY 2005 VL 2 IS 4 BP 263 EP 267 DI 10.1115/1.2041668 PG 5 GA 048KQ UT WOS:000237946400008 ER PT J AU Trefry, CM Watkins, DW Johnson, D AF Trefry, CM Watkins, DW Johnson, D TI Regional rainfall frequency analysis for the state of Michigan SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article ID PROBABILITY-WEIGHTED MOMENTS; DURATION SERIES METHOD; EXTREME PRECIPITATION; UNITED-STATES; FLOOD AB Effective storm water management plans depend on reliable rainfall intensity-duration-frequency (IDF) relationships. Due to the perception of high-intensity rainfall events as occurring more frequently than expected, the Michigan Dept. of Transportation (MDOT) commissioned a study to update rainfall IDF estimates for each of seven durations (1, 2, 3, 6, 12, 18, and 24 h) and six recurrence intervals (2, 5, 10, 25, 50, and 100 years). In contrast to a traditional at-site frequency analysis using method of moments estimators, this study applied a regional frequency analysis approach based on L-moments. Data were compiled from 76 hourly recording stations and 152 daily recording stations, and trend and outlier analyses were conducted on both annual maximum series (AMS) and partial duration series (PDS) data. With the entire state considered a homogeneous region, two regional index flood models were applied: a generalized Pareto distribution fit to PDS data (PDS/GPA model), and a generalized extreme value distribution fit to AMS data (AMS/GEV model). Verification of results indicated that the revised rainfall IDF estimates provide more reliable values than those previously used. C1 USA, Corps Engineers, Rock Isl, IL 61204 USA. Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA. Juniata Coll, Dept Environm Sci & Studies, Juniata, PA 16652 USA. RP Trefry, CM (reprint author), USA, Corps Engineers, POB 2004, Rock Isl, IL 61204 USA. EM christopher.m.trefry@usace.army.mil; dwatkins@mtu.edu; johnson@juniata.edu NR 41 TC 38 Z9 38 U1 0 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 J9 J HYDROL ENG JI J. Hydrol. Eng. PD NOV-DEC PY 2005 VL 10 IS 6 BP 437 EP 449 DI 10.1061/(ASCE)1084-0699(2005)10:6(437) PG 13 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 976TU UT WOS:000232757100001 ER PT J AU Tenbrock, K Kyttaris, VC Ahlmann, M Ehrchen, JA Tolnay, M Melkonyan, H Mawrin, C Roth, J Sorg, C Juang, YT Tsokos, GC AF Tenbrock, K Kyttaris, VC Ahlmann, M Ehrchen, JA Tolnay, M Melkonyan, H Mawrin, C Roth, J Sorg, C Juang, YT Tsokos, GC TI The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain SO JOURNAL OF IMMUNOLOGY LA English DT Article ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; CELL SIGNALING ABNORMALITIES; T-CELLS; DECREASED EXPRESSION; IL-2 PRODUCTION; PROTEIN; PROMOTER; BINDING; ELF-1; PHOSPHORYLATION AB Systemic lupus erythematusus T cells display decreased amounts of TCR zeta mRNA that results in part from limited binding of the transcriptional enhancer Elf-1 to the TCR zeta promoter. We have identified a new cis-binding site for the cAMP response element (CRE) modulator (CREM) on the TCR zeta promoter, centered on the -390 nucleotide. Transfection of T cells with an antisense CREM alpha plasmid reduced the binding of CREM to the TCR zeta promoter, as shown by chromatin and reporter chromatin immunoprecipitation assays, and enhanced the production of TCR zeta mRNA and protein. Mutagenesis of the -390 CRE site prevented the binding of CREM to the TCR zeta promoter. The mechanism of CREM-mediated repression appears to be chromatin dependent, because antisense CREM promotes the acetylation of histones on the TCR zeta promoter. Finally, we established an enhanced binding of CREM to the TCR zeta-chain promoter in systemic lupus erythematosus cells compared with control T cells. Our studies demonstrate that CREM a binds to the TCR zeta promoter and repress its activity. C1 Univ Hosp Munster, Dept Pediat, Div Rheumatol, Inst Expt Dermatol,Interdisciplinary Ctr Clin Res, D-48149 Munster, Germany. Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. Childrens Hosp, Rheumatol Sect, Washington, DC 20010 USA. US FDA, Div Monoclonal Antibodies, Rockville, MD 20857 USA. RP Tenbrock, K (reprint author), Univ Hosp Munster, Dept Pediat, Div Rheumatol, Inst Expt Dermatol,Interdisciplinary Ctr Clin Res, Res Grp 5,Roentgenstr 21, D-48149 Munster, Germany. EM ktenbroc@uni-muenster.de NR 16 TC 29 Z9 32 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 1 PY 2005 VL 175 IS 9 BP 5975 EP 5980 PG 6 WC Immunology SC Immunology GA 977EW UT WOS:000232786300053 PM 16237091 ER PT J AU Bautista, E Clemmens, AJ AF Bautista, E Clemmens, AJ TI Volume compensation method for routing irrigation canal demand changes SO JOURNAL OF IRRIGATION AND DRAINAGE ENGINEERING-ASCE LA English DT Article ID FLOW AB This paper examines the problem of routing known water demands through gate-controlled, open-channel irrigation delivery systems. Volume-compensation principles were used to route multiple demands in multi P le-pool canal systems. The volume-compensation method schedules each demand change individually under the assumption of a series of steady stales and superimposes the individual results. Volume-compensation routing schedules were computed for two of the test cases proposed by the ASCE Task Committee on Canal Automation. Alternative routing schedules were computed with the gate-stroking method, which is an inverse solution of the unsteady-flow equations. Both solutions were tested through unsteady-flow simulation. While not as effective its gate-stroking Solutions, volume-compensation solutions performed satisfactorily tinder ideal flow control conditions. When subjected to realistic operational constraints, specifically constraints on the flow regulation interval, and also to incorrect canal hydraulic toughness information, both methods performed similarly. C1 USA, ARS, US Water Conservat Lab, Phoenix, AZ 85040 USA. RP Bautista, E (reprint author), USA, ARS, US Water Conservat Lab, 4331 E Broadway Rd, Phoenix, AZ 85040 USA. EM ebautista@uswel.ars.ag.gov; bclemmens@uswel.ars.ag.gov NR 16 TC 18 Z9 28 U1 0 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9437 J9 J IRRIG DRAIN E-ASCE JI J. Irrig. Drainage Eng-ASCE PD NOV-DEC PY 2005 VL 131 IS 6 BP 494 EP 503 DI 10.1061/(ASCE)0733-9437(2005)131:6(494) PG 10 WC Agricultural Engineering; Engineering, Civil; Water Resources SC Agriculture; Engineering; Water Resources GA 986UY UT WOS:000233476400001 ER PT J AU Folkes, PA AF Folkes, PA TI Voltage-induced anomalous excitonic photoluminescence from a single heterojunction quantum well SO JOURNAL OF LUMINESCENCE LA English DT Article DE semiconductor; many body; excitonic molecule; relaxation ID 2-DIMENSIONAL ELECTRON-GAS; OPTICAL-ABSORPTION; BIEXCITONS; SEMICONDUCTORS; RECOMBINATION; SPECTROSCOPY; CONDENSATION; TRANSITION; DYNAMICS; HOLES AB Excitons which coexist with a degenerate two-dimensional electron gas (2DEG) in the same quantum well subband have been observed in the photoluminescence (PL) from the recombination of electrons with localized photoexcited holes. We observe a strong decrease in the exciton PL intensity and the concomitant appearance of another peak around 2meV lower than the exciton energy when the 2DEG density approximate to 1.9 X 10(11) cm(-2). Over a small range of excitation intensity with the 2DEG density approximate to 1.9 X 10(11) cm(-2), we observe anomalous changes in the PL spectra which are very sensitive to an applied gate voltage and suggest that the lower energy peak can be attributed to biexcitons which have undergone a phase transition into an ordered collective phase. (c) 2005 Elsevier B.V. All rights reserved. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Folkes, PA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM pfolkes@arl.army.mil NR 31 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2313 J9 J LUMIN JI J. Lumines. PD NOV-DEC PY 2005 VL 115 IS 3-4 BP 104 EP 108 DI 10.1016/j.jlumin.2005.02.017 PG 5 WC Optics SC Optics GA 968OI UT WOS:000232171400004 ER PT J AU Moncayo, AC Lerdthusnee, K Leon, R Robich, RM Romoser, WS AF Moncayo, AC Lerdthusnee, K Leon, R Robich, RM Romoser, WS TI Meconial peritrophic matrix structure, formation, and meconial degeneration in mosquito pupae/pharate adults: Histological and ultrastructural aspects SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE peritrophic matrix; meconial PM; mosquito; histology; ultrastructure ID AEDES-TRISERIATUS DIPTERA; ELECTRON MICROSCOPY; CULICIDAE; MEMBRANES; PUPAL; INSECTS; FATE AB The noncellular peritrophic matrix (PM) that forms around the food bolus in the midgut of many arthropod species may influence the fate of ingested microbes. In mosquitoes, PMs have been identified in the pupal as well as larval and adult stages. In pupae, the PMs surround the meconium, the sloughed larval midgut epithelium. Meconial PM1 (MPM1) forms early in the pupal stadium, and a second meconial PM (MPM2) sometimes forms around the time of adult emergence. A recent study suggests that MPMs contribute to the sterilization of the adult midgut by sequestering in microorganisms ingested during the larval stage, which, along with remaining meconial material, are egested after adult emergence. We have compared MPM1 formation and patterns of meconial degeneration in representative species in five mosquito genera and identified a temporal association between MPM1 formation, meconial degeneration, and apolysis. Ultrastructural study of MPM1 and MPM2 in Aedes aegypti (L.) revealed that MPM1 seems to be structurally different from either the larval or adult PMs, whereas MPM2 more closely resembles PM formed around a bloodmeal in adult females. Our results are consistent with the microbial sequestration role. C1 Tennessee Dept Hlth Communicable & Environm Dis S, Nashville, TN 37247 USA. Armed Forces Res Inst Med Sci, Dept Entomol, USAMC, Bangkok 10400, Thailand. Univ San Francisco Quito, Inst Microbiol, Quito, Ecuador. Ohio State Univ, Dept Entomol, Columbus, OH 43210 USA. Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Trop Dis Inst, Athens, OH 45701 USA. RP Moncayo, AC (reprint author), Tennessee Dept Hlth Communicable & Environm Dis S, 4th Floor,Cordell Hull Bldg,425 5th Ave N, Nashville, TN 37247 USA. NR 25 TC 12 Z9 12 U1 2 U2 6 PU ENTOMOLOGICAL SOCIETY AMERICA PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2005 VL 42 IS 6 BP 939 EP 944 DI 10.1603/0022-2585(2005)042[0939:MPMSFA]2.0.CO;2 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 983DJ UT WOS:000233211000003 PM 16465731 ER PT J AU Bauer, AJ Stratakis, CA AF Bauer, AJ Stratakis, CA TI The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis SO JOURNAL OF MEDICAL GENETICS LA English DT Review ID PROTEIN-KINASE-A; PEUTZ-JEGHERS-SYNDROME; GENOTYPE-PHENOTYPE ANALYSES; MESSENGER-RNA TRANSLATION; LHERMITTE-DUCLOS-DISEASE; BANNAYAN-ZONANA-SYNDROME; GERMLINE PTEN MUTATION; TUMOR-SUPPRESSOR GENE; SUBUNIT TYPE 1A; CARNEY-COMPLEX AB Familial lentiginosis syndromes cover a wide phenotypic spectrum ranging from a benign inherited predisposition to develop cutaneous lentigines unassociated with systemic disease, to associations with several syndromes carrying increased risk of formation of hamartomas, hyperplasias, and other neoplasms. The molecular pathways involved in the aetiology of these syndromes have recently been more clearly defined and several major cellular signalling pathways are probably involved: the protein kinase A (PKA) pathway in Carney complex (CNC), the Ras/Erk MAP kinase pathway in LEOPARD/Noonan syndromes, and the mammalian target of rapamycin pathway (mTOR) in Peutz-Jeghers syndrome and the diseases caused by PTEN mutations. Here we discuss the clinical presentation of these disorders and discuss the molecular mechanisms involved. The presence of lentigines in these diseases caused by diverse molecular defects is probably more than an associated clinical feature and likely reflects cross talk and convergence of signalling pathways of central importance to embryogenesis, neural crest differentiation, and end-organ growth and function of a broad range of tissues including those of the endocrine, reproductive, gastrointestinal, cardiac, and integument systems. C1 NICHD, Sect Endocrinol & Genet, DEB, NIH,CRC, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Stratakis, CA (reprint author), NICHD, Sect Endocrinol & Genet, DEB, NIH,CRC, Bldg 10,Room 1-3330,10 Ctr Dr,MSC 1103, Bethesda, MD 20892 USA. EM stratakc@mail.nih.gov NR 118 TC 28 Z9 30 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0022-2593 J9 J MED GENET JI J. Med. Genet. PD NOV PY 2005 VL 42 IS 11 BP 801 EP 810 DI 10.1136/jmg.2003.017806 PG 10 WC Genetics & Heredity SC Genetics & Heredity GA 980XB UT WOS:000233050400001 PM 15958502 ER PT J AU Ciezak, JA Trevino, SF AF Ciezak, JA Trevino, SF TI Theoretical and experimental study of the inelastic neutron scattering spectra of beta-5-Nitro-2,4-dihydro-3H-1,2,4-triazol-3-one SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE beta-NTO; inelastic neutron scattering; NTO; 5-Nitro-2,4-dihydro-3H-1,2,4-triazol-3-one ID DENSITY-FUNCTIONAL THEORY; VIBRATIONAL-SPECTRA; ENERGETIC MATERIALS; MOLECULAR VIBRATIONS; RAMAN-SPECTROSCOPY; CRYSTAL-STRUCTURE; MODEL PEPTIDE; 2,6-DIAMINO-3,5-DINITROPYRAZINE; EXPLOSIVES; DYNAMICS AB The inelastic neutron scattering (INS) spectra of P-5-Nitro-2,4-dihydro-3H-1,2,4-triazol-3-one (beta-NTO) are presented to 1400 cm(-1). The beta-NTO vibrational frequencies observed differ considerably from the alpha-NTO vibrational frequencies and normal mode frequency calculations for the isolated molecule. The INS spectrum contains detail unobserved in the previous IR studies, including combinations and overtones of the phonon and internal modes of beta-NTO. The INS spectra are compared with periodic DFT calculations to show that the periodic DFT results correctly predict the solid-state molecular vibrational frequencies. Published by Elsevier B.V. C1 USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak, JA (reprint author), 100 Bur Dr,MS 8562, Gaithersburg, MD 20899 USA. EM jciezak@arl.army.mil NR 38 TC 6 Z9 6 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD NOV 1 PY 2005 VL 732 IS 1-3 BP 211 EP 218 DI 10.1016/j.theochem.2005.07.022 PG 8 WC Chemistry, Physical SC Chemistry GA 982TB UT WOS:000233183400023 ER PT J AU Neal, CJ Rosner, MK Kuklo, TR AF Neal, CJ Rosner, MK Kuklo, TR TI Magnetic resonance imaging evaluation of adjacent segments after disc arthroplasty SO JOURNAL OF NEUROSURGERY-SPINE LA English DT Article DE arthroplasty; lumbar spine; Maverick disc; magnetic resonance imaging; adjacent-segment degeneration ID FOLLOW-UP PERIOD; LUMBAR FUSION; ARTIFICIAL DISC; INTERVERTEBRAL DISC; REPLACEMENT; PROSTHESIS; DEGENERATION; MULTICENTER; ARTIFACTS; DESIGN AB Object. Disc arthroplasty in the lumbar spine is an alternative to fusion when treating discogenic pain. Its theoretical benefits include preservation of the motion segment and the potential prevention of adjacent-segment degeneration. Despite the need to evaluate the benefit of preserving the adjacent segments after disc replacement, no study has been conducted to assess the ability of magnetic resonance (MR) imaging to depict the adjacent segments in patients who have undergone disc replacement surgery. Methods. Postoperative lumbar MR images were obtained in the first 10 patients in whom a metal-on-metal disc arthroplasty system was used to treat the L4-5 or L5-S1 levels. At the superior adjacent level, the superior endplate and disc space were demonstrated on 90% of the images on both T-1-weighted fluid-attenuated inversion-recovery (FLAIR) and T-2-weighted sequences despite the presence of artifacts. The inferior endplate at this level was documented on 70% of both T-1-weighted FLAIR and T-2-weighted sequences. At the level below the disc replacement in patients who underwent L4-5 surgery, the superior endplate was demonstrated on 66.7% of the T-1-weighted FLAIR sequences but only 33.3% of the T-2- weighted images. The disc space and inferior endplate were depicted on 66.7% of both T-1-weighted FLAIR and T-2-weighted sequences. Axial images revealed an artifact in every adjacent space except at the L5-S1 level. Conclusions. Based on the results of this pilot study, it appears that sagittal MR imaging can be undertaken to evaluate the adjacent motion segment for degenerative changes following total disc arthroplasty in most patients. This imaging modality will provide an additional measure to assess the long-term efficacy of this intervention compared with other treatment modalities and the natural history of lumbar disc degeneration. C1 Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Orthopaed, Washington, DC 20307 USA. Natl Naval Med Res Inst, Dept Neurosurg, Bethesda, MD USA. RP Neal, CJ (reprint author), Walter Reed Army Med Ctr, Dept Neurosurg, 6900 Georgia Ave,Bldg 2 Room 6446, Washington, DC 20307 USA. EM chris.neal@na.amedd.anny.mil NR 25 TC 10 Z9 11 U1 0 U2 0 PU AMER ASSOC NEUROLOGICAL SURGEONS PI CHARLOTTESVILLE PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 USA SN 1547-5654 J9 J NEUROSURG-SPINE JI J. Neurosurg.-Spine PD NOV PY 2005 VL 3 IS 5 BP 342 EP 347 DI 10.3171/spi.2005.3.5.0342 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 979GT UT WOS:000232931100002 PM 16302627 ER PT J AU Riechers, RG Ramage, A Brown, W Kalehua, A Rhee, P Ecklund, JM Ling, GSF AF Riechers, RG Ramage, A Brown, W Kalehua, A Rhee, P Ecklund, JM Ling, GSF TI Physician knowledge of the Glasgow Coma Scale SO JOURNAL OF NEUROTRAUMA LA English DT Article DE brain trauma; Glasgow Coma Scale; human; outcome; triage ID ACUTE PHYSIOLOGY; INTENSIVE-CARE; APACHE-II; RELIABILITY; SCORE AB Appropriate triage is critical to optimizing outcome from battle related injuries. The Glasgow Coma Scale (GCS) is the primary means by which combat casualties, who have suffered head injury, are triaged. For the GCS to be reliable in this critical role, it must be applied accurately. To determine the level of knowledge of the GCS among military physicians with exposure and/or training in the scale we administered a prospective, voluntary, and anonymous survey to physicians of all levels of training at military medical centers with significant patient referral base. The main outcome measures were correct identification of title and categories of the GCS along with appropriate scoring of each category. Overall performance on the survey was marginal. Many were able to identify what "GCS" stands for, but far fewer were able to identify the titles of the specific categories, let alone identify the specific scoring of each category. When evaluated based on medical specialties, those in surgical specialties outperformed those in the medical specialties. When comparing the different levels of training, residents and fellows performed better than attending staff or interns. Finally, those with Advanced Trauma Life Support (ATLS) certification performed significantly better than those without the training. Physician knowledge of the GCS, as demonstrated in this study, is poor, even in a population of individuals with specific training in the use of the scale. It is concluded that, to optimize outcome from combat related head injury, methods for improving accurate quantitation of neurologic state need to be explored. C1 Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. Eisenhower Army Med Ctr, Dept Internal Med, Augusta, GA USA. Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. Univ So Calif, Los Angeles Cty Med Ctr, Navy Trauma Training Ctr, Los Angeles, CA 90033 USA. RP Riechers, RG (reprint author), Walter Reed Army Med Ctr, Dept Neurol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM ronald.riechers@na.amedd.army.mil NR 21 TC 25 Z9 26 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD NOV PY 2005 VL 22 IS 11 BP 1327 EP 1334 DI 10.1089/neu.2005.22.1327 PG 8 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 989OI UT WOS:000233683000007 PM 16305321 ER PT J AU Deyle, GD AF Deyle, GD TI Musculoskeletal imaging in physical therapist practice SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Review DE clinical decision rule; diagnosis; diagnostic imaging ID OTTAWA ANKLE RULES; LOW-BACK-PAIN; CLINICAL DECISION RULES; ACUTE KNEE INJURIES; DEEP-VEIN THROMBOSIS; ROTATOR CUFF TEARS; ADOLESCENT IDIOPATHIC SCOLIOSIS; OCCULT HIP-FRACTURES; MINOR HEAD-INJURY; C-SPINE RULE AB This article presents an overview of current concepts of evidence-based diagnosis using a variety of imaging modalities for a broad spectrum of musculoskeletal conditions and syndromes. There is limited but increasing evidence that physical therapists appropriately use diagnostic studies in clinical practice. Pathology revealed by diagnostic studies must be viewed in the context of the complete examination, as pathology is common in the asymptomatic population. Special diagnostic challenges are presented by patients with areas of referred pain, multiple injuries or multiple areas of pathology, neoplasms, and infections. Plain film radiographs have been overused in the clinical management of many conditions, including low back pain. Clinical decision rules provide simple evidence-based guidelines for the appropriate use of imaging studies. C1 Rocky Mt Univ Hlth Profess, Provo, UT USA. Baylor Univ, USA, Univ Post Profess Doctoral Program Orthopaed Manu, Brooke Army Med Ctr, Ft Sam Houston, TX USA. RP Deyle, GD (reprint author), 3 Sherborne Wood, San Antonio, TX 78218 USA. EM gdeyle@satx.rr.com NR 133 TC 5 Z9 5 U1 0 U2 3 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD NOV PY 2005 VL 35 IS 11 BP 708 EP 721 PG 14 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 984MJ UT WOS:000233308700003 PM 16355913 ER PT J AU Garber, MB AF Garber, MB TI Diagnostic imaging and differential diagnosis in 2 case reports SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE anterolisthesis; disc herniation; neurosurgery; stress fracture ID C-SPINE RULE; CERVICAL SPONDYLOTIC MYELOPATHY; AVULSION; FRACTURE; TRAUMA; PAIN AB Background: In today's healthcare setting, it is important for physical therapists to recognize when diagnostic imaging is necessary-as well as know how to interpret the results of these tests-to assist in the clinical decision-making process. Two cases are presented that illustrate how a physical therapist, credentialed to request and review diagnostic imaging, effectively and efficiently utilized multiple forms of diagnostic imaging to assist in his differential diagnosis and clinical decision making. Diagnosis: The first case report describes the differential diagnostic process for a 33-year-old active duty military paratrooper who had sustained trauma to his neck. His history was consistent with a C6 radiculopathy, which was confirmed by a neurological screening examination. Radiographs requested by the physical therapist revealed an anterolithesis of C5 on C6, with a possible fracture. An orthopedic surgeon was consulted and further diagnostic testing via magnetic resonance imaging revealed a large disc herniation at C5-6, with spinal cord compression, as well as a C5 vertebral body fracture with nearly perched facets at C5 on C6. The patient was subsequently referred to a neurosurgeon and underwent an emergency C5-6 fusion that afternoon, The second case report describes the differential diagnosis of a 20-year-old active-duty soldier referred for rehabilitation with a diagnosis of a distal fibula stress fracture. Previous treatment by the referring provider included 3 months of rest and anti-inflammatory medications. Physical examination of the patient revealed a marked decrease in ankle inversion with a firm end feel. This was not consistent with the diagnosis established by the referring provider. Subsequent radiographs requested by the physical therapist and a computed tomography scan requested by a podiatrist revealed synostosis of the middle facet of the talocalcaneal joint with an apparent fracture line. The patient subsequently underwent a subtalar arthrodesis. Discussion: In these cases the physical therapist requested imaging needed for appropriate management, despite the patient having previously seen a primary care provider. In both examples, the physical therapist successfully identified abnormalities prior to a radiologist or other physician reviewing the results. This avoided delay in definitive management of the patients' problems. It is imperative that physical therapists understand when diagnostic imaging is necessary to assist in the differential diagnosis of patients. Likewise, it is important for physical therapists to be competent in interpreting the results of these tests. When not in a direct access physical therapy environment, a physical therapist should understand when diagnostic imaging tests are indicated. This facilitates working with the entire health care team to acquire necessary tests in an appropriate timeframe. C1 Brooke Army Med Ctr, MCHE, DORPT, Ft Sam Houston, TX 78234 USA. RP Garber, MB (reprint author), Brooke Army Med Ctr, MCHE, DORPT, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM matthew.garber@us.army.mil NR 28 TC 7 Z9 7 U1 2 U2 4 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD NOV PY 2005 VL 35 IS 11 BP 745 EP 754 PG 10 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 984MJ UT WOS:000233308700007 PM 16355917 ER PT J AU Hsu, S Dickinson, DP Qin, HY Lapp, C Lapp, D Borke, J Walsh, DS Bollag, WB Stoppler, HS Yamamoto, T Osaki, T Schuster, G AF Hsu, S Dickinson, DP Qin, HY Lapp, C Lapp, D Borke, J Walsh, DS Bollag, WB Stoppler, HS Yamamoto, T Osaki, T Schuster, G TI Inhibition of autoantigen expression by (-)-epigallocatechin-3-gallate (the Major Constituent of Green Tea) in normal human cells SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; SALIVARY-GLAND CELLS; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; SJOGRENS-SYNDROME; SURFACE EXPRESSION; EPITHELIAL-CELLS; EPIGALLOCATECHIN-3-GALLATE; KERATINOCYTES; PROTEIN AB Autoimmune disorders, characterized by inflammation and apoptosis of target cells leading to tissue destruction, are mediated in part by autoantibodies against normal cellular components (autoantigens) that may be overexpressed. For example, antibodies against the autoantigens SS-A/Ro and SS-B/La are primary markers for systemic lupus erythematosus and Sjogren's syndrome. Recently, studies in animals demonstrated that green tea consumption may reduce the severity of some autoimmune disorders, but the mechanism is unclear. Herein, we sought to determine whether the most abundant green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), affects autoantigen expression in human cells. Cultures of pooled normal human primary epidermal keratinocytes and of an immortalized human salivary acinar cell line were incubated with 100 mu M EGCG (a physiologically achievable level for topical application or oral administration) for various time periods and then analyzed by cDNA microarray analysis, reverse transcriptionpolymerase chain reaction, and Western blotting for expression of several major autoantigen candidates. EGCG inhibited the transcription and translation of major autoantigens, including SS-B/La, SS-A/Ro, coilin, DNA topoisomerase I, and alpha-fodrin. These findings, taken together with green tea's anti-inflammatory and antiapoptotic effects, suggest that green tea polyphenols could serve as an important component in novel approaches to combat autoimmune disorders in humans. C1 Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, Augusta, GA 30912 USA. Kochi Med Sch, Dept Oral Surg, Kochi, Japan. Eisenhower Army Med Ctr, Dermatol Serv, Ft Gordon, GA USA. Med Coll Georgia, Dept Biochem & Mol Biol, Augusta, GA 30912 USA. Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA USA. RP Hsu, S (reprint author), Med Coll Georgia, Sch Dent, Dept Oral Biol & Maxillofacial Pathol, AD1443, Augusta, GA 30912 USA. EM shsu@mail.mcg.edu RI Dickinson, Douglas/B-9111-2009 FU NCI NIH HHS [R21 CA97258-01A1] NR 40 TC 14 Z9 14 U1 1 U2 1 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD NOV PY 2005 VL 315 IS 2 BP 805 EP 811 DI 10.1124/jpet.105.090399 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 975SD UT WOS:000232681300038 PM 16046615 ER PT J AU Kozar, RA Moore, JB Niles, SE Holcomb, JB Moore, EE Cothren, CC Hartwell, E Moore, FA AF Kozar, RA Moore, JB Niles, SE Holcomb, JB Moore, EE Cothren, CC Hartwell, E Moore, FA TI Complications of nonoperative management of high-grade blunt hepatic injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 35th Annnual Meeting of the Western-Trauma-Association CY FEB 27-MAR 05, 2005 CL Jackson Hole, WY SP Western Trauma Assoc DE blunt hepatic injuries; nonoperative management; biloma; angioembolization ID ABDOMINAL COMPARTMENT SYNDROME; LIVER-INJURIES; ANGIOGRAPHIC EMBOLIZATION; NONSURGICAL MANAGEMENT; TRAUMA; PERITONITIS; EXPERIENCE; OUTCOMES; SPLEEN; NEED AB Background: Nonoperative management of blunt hepatic injuries is highly successful. Complications associated with high-grade injuries, however, have not been well characterized. The purpose of the present study was therefore to define hepatic-related complications and associated treatment modalities in patients undergoing non-operative management of high-grade blunt hepatic injuries. Methods: Three hundred thirty-seven patients from two regional Level I trauma centers with grade 3 to 5 blunt hepatic injuries during a 40-month period were reviewed. Complications and treatment of hepatic-related complications in patients not requiring laparotomy in the first 24 hours were identified. Results: Of 337 patients with a grade 3 to 5 injury, 230 (68%) were managed non-operatively. There were 37 hepatic-related complications in 25 patients (11%); 63% (5 of 8) of patients with grade 5 injuries developed complications, 21% (19 of 92) of patients with grade 4 injuries, but only 1 % (1 of 130) of patients with grade 3 injuries. Complications included bleeding in 13 patients managed by angioembolization (n = 12) and laparotomy (n = 1), liver abscesses in 2 patients managed with computed tomography-guided drainage (n = 2) and subsequent laparotomy (n = 1). In one patient with bleeding, hepatic necrosis followed surgical ligation of the right hepatic artery and required delayed hepatic lobectomy. Sixteen biliary complications were managed with endoscopic retrograde cholangiopancreatography and stenting (n = 7), drainage (n = 5), and laparoscopy (n = 4). Three patients had suspected abdominal sepsis and underwent a negative laparotomy, whereas an additional three patients underwent laparotomy for abdominal compartment syndrome. Conclusion: Nonoperative management of high-grade liver injuries can be safely accomplished. Mortality is low; however, complications in grade 4 and 5 injuries should be anticipated and may require a combination of operative and nonoperative management strategies. C1 Univ Texas, Dept Surg, Houston, TX 77030 USA. Univ Texas, Dept Pathol, Houston, TX 77030 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Denver Hlth Med Ctr, Denver, CO USA. RP Kozar, RA (reprint author), Univ Texas, Dept Surg, 6431 Fannin,MS 4-284, Houston, TX 77030 USA. EM rosemary.a.kozar@uth.tmc.edu NR 28 TC 80 Z9 90 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2005 VL 59 IS 5 BP 1066 EP 1071 DI 10.1097/01.ta.0000188937.75879.ab PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 001DO UT WOS:000234514000008 PM 16385280 ER PT J AU Horvath, LL Murray, CK Dooley, DP AF Horvath, LL Murray, CK Dooley, DP TI Effect of maximizing a travel medicine clinic's prevention strategies SO JOURNAL OF TRAVEL MEDICINE LA English DT Article; Proceedings Paper CT 52nd Meeting of the American-Society-for-Tropical-Medicine-and-Hygiene CY DEC 03-07, 2003 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg ID HEALTH-PROBLEMS; DEVELOPING-COUNTRIES; ILLNESS AB Background: Even among travelers who undergo evaluation in travel medicine clinics, illnesses develop despite the emphasis placed on prevention. It is possible that travel-associated disease rates may be modified by maximizing access to care and augmenting educational methods of disease prevention. Use of alternative preventive measures such as alcohol hand gel sanitizers may also alter illnesses among travelers. Methods:We assessed medical outcomes in a travel population cared for in the setting of free vaccinations, medications, and travel medicine consultation, in which personal preventive measures were presented in numerous formats by a physician specializing in infectious diseases. An initial demographic questionnaire was administered at the time of travel consultation. A post-travel telephone interview conducted 2 weeks after return from travel evaluated illness while abroad, illness upon return, and adherence to travel recommendations. An assessment was also performed regarding the utility of an alcohol hand gel sanitizer. Results: One hundred fifty-five travelers were evaluated (primarily older, well-educated US-born travelers, on vacation with family or coworkers). Travelers filled their prescriptions 98% of the time; 77% reported adherence to antimalarial chemoprophylaxis. Sixty-four percent of travelers developed illness abroad, and 20% developed illness upon return. The most frequent complaints were diarrhea and upper respiratory illness. Ten percent of travelers altered their itinerary owing to illness. The use of alcohol hand gel sanitizers did not appear to impact the development of diarrhea or respiratory illnesses. Conclusion: In this small group of travelers, access to free consultation, vaccinations, and medications along with presentation of personal protective measures in various formats did not seem to influence the development of illnesses among travelers. Although not rigorously analyzed, alcohol hand gel sanitizers did not seem to alter diarrhea or respiratory tract illness rates. These data highlight the need for new or more effective methods to prevent illness among travelers. C1 Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Infect Dis Serv, Dept Med, Ft Sam Houston, TX 78234 USA. RP Horvath, LL (reprint author), Brooke Army Med Ctr, Dept Clin Invest, 3400 Rawley E Chambers Ave,Suite A, Ft Sam Houston, TX 78234 USA. NR 10 TC 10 Z9 11 U1 0 U2 0 PU B C DECKER INC PI HAMILTON PA 20 HUGHSON ST SOUTH, PO BOX 620, L C D 1, HAMILTON, ONTARIO L8N 3K7, CANADA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD NOV-DEC PY 2005 VL 12 IS 6 BP 332 EP 337 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 999LF UT WOS:000234390100006 PM 16343385 ER PT J AU Abularrage, CJ Sidawy, AN Weiswasser, JM White, PW Aidinian, G Arora, S AF Abularrage, CJ Sidawy, AN Weiswasser, JM White, PW Aidinian, G Arora, S TI Chronic mesenteric ischemia: Treatment of recurrent disease SO JOURNAL OF VASCULAR SURGERY LA English DT Article C1 Vet Affairs Med Ctr, Dept Surg, Washington, DC 20422 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. George Washington Univ, Med Ctr, Dept Surg, Washington, DC 20037 USA. RP Abularrage, CJ (reprint author), Vet Affairs Med Ctr, Dept Surg, 50 Irving St NW, Washington, DC 20422 USA. NR 1 TC 4 Z9 4 U1 0 U2 0 PU MOSBY, INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD NOV PY 2005 VL 42 IS 5 BP 1026 EP 1026 DI 10.1016/j.jvs.2005.01.019 PG 1 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 981LL UT WOS:000233090000044 PM 16275467 ER PT J AU Olinger, GG Bailey, MA Dye, JM Bakken, R Kuehne, A Kondig, J Wilson, J Hogan, RJ Hart, MK AF Olinger, GG Bailey, MA Dye, JM Bakken, R Kuehne, A Kondig, J Wilson, J Hogan, RJ Hart, MK TI Protective cytotoxic T-cell responses induced by Venezuelan equine encephalitis virus replicons expressing Ebola virus proteins SO JOURNAL OF VIROLOGY LA English DT Article ID HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; GUINEA-PIGS; IMMUNE-RESPONSES; MARBURG VIRUSES; MOUSE MODEL; INFECTION; VACCINES; MICE; VP40 AB Infection with Ebola virus causes a severe disease accompanied by high mortality rates, and there are no licensed vaccines or therapies available for human use. Filovirus vaccine research efforts still need to determine the roles of Immoral and cell-mediated immune responses in protection from Ebola virus infection. Previous studies indicated that exposure to Ebola virus proteins expressed from packaged Venezuelan equine encephalitis virus replicons elicited protective immunity in mice and that antibody-mediated protection could only be demonstrated after vaccination against the glycoprotein. In this study, the murine CD8(+) T-cell responses to six Ebola virus proteins were examined. CD8(+) T cells specific for Ebola virus glycoprotein, nucleoprotein, and viral proteins (VP24, VP30, VP35, and VP40) were identified by intracellular cytokine assays using splenocytes from vaccinated mice. The cells were expanded by restimulation with peptides and demonstrated cytolytic activity. Adoptive transfer of the CD8(+) cytotoxic T cells protected filovirus naive mice from challenge with Ebola virus. These data support a role for CD8(+) cytotoxic T cells as part of a protective mechanism induced by vaccination against six Ebola virus proteins and provide additional evidence that cytotoxic T-cell responses can contribute to protection from filovirus infections. C1 USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. RP Hart, MK (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21702 USA. EM marykate.hart@amedd.army.mil OI Olinger, Gene/0000-0001-7338-0292 NR 40 TC 51 Z9 52 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 2005 VL 79 IS 22 BP 14189 EP 14196 DI 10.1128/JVI.79.22.14189-14196.2005 PG 8 WC Virology SC Virology GA 980ER UT WOS:000232997500036 PM 16254354 ER PT J AU Lytle, CD Sagripanti, JL AF Lytle, CD Sagripanti, JL TI Predicted inactivation of viruses of relevance to biodefense by solar radiation SO JOURNAL OF VIROLOGY LA English DT Article ID HOST-CELL REACTIVATION; HERPES-SIMPLEX VIRUS; MONOCHROMATIC ULTRAVIOLET-RADIATION; NEWCASTLE-DISEASE VIRUS; MURINE LEUKEMIA-VIRUS; UV-IRRADIATION; ENHANCED REACTIVATION; MAMMALIAN-CELLS; ACTION SPECTRA; MULTIPLICITY REACTIVATION AB UV radiation from the sun is the primary germicide in the environment. The goal of this study was to estimate inactivation of viruses by solar exposure. We reviewed published reports on 254-nm UV inactivation and tabulated the sensitivities of a wide variety of viruses, including those with double-stranded DNA, single-stranded DNA, double-stranded RNA, or single-stranded RNA genomes. We calculated D,, values (fluence producing on average one lethal hit per virion and reducing viable virus to 37%) from all available data. We defined "size-normalized sensitivity" (SnS) by multiplying UV254 sensitivities (D-37 values) by the genome size, and SnS values were relatively constant for viruses with similar genetic composition. In addition, SnS values were similar for complete virions and their defective particles, even when the corresponding D37 values were significantly different. We used SnS to estimate the UV254 sensitivities of viruses for which the genome composition and size were known but no UV inactivation data were available, including smallpox virus, Ebola, Marburg, Crimean-Congo, Junin, and other hemorrhagic viruses, and Venezuelan equine encephalitis and other encephalitis viruses. We compiled available data on virus inactivation as a function of wavelength and calculated a composite action spectrum that allowed extrapolation from the 254-nm data to solar UV. We combined our estimates of virus sensitivity with solar measurements at different geographical locations to predict virus inactivation. Our predictions agreed with the available experimental data. This work should be a useful step to understanding and eventually predicting the survival of viruses after their release in the environment. C1 USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Sagripanti, JL (reprint author), USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Res & Technol Directorate, AMSRD,ECB,RT, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil NR 89 TC 73 Z9 76 U1 1 U2 19 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 2005 VL 79 IS 22 BP 14244 EP 14252 DI 10.1128/JVI.79.22.14244-14252.2005 PG 9 WC Virology SC Virology GA 980ER UT WOS:000232997500041 PM 16254359 ER PT J AU Friedl, KE AF Friedl, KE TI Biomedical research on health and performance of military women: Accomplishments of the Defense Women's Health Research Program (DWHRP) SO JOURNAL OF WOMENS HEALTH LA English DT Review ID MENSTRUAL-CYCLE PHASE; FEMALE FLIGHT ATTENDANTS; CHLAMYDIA-TRACHOMATIS-INFECTIONS; IMMUNODEFICIENCY-VIRUS TYPE-1; ADDUCTOR POLLICIS MUSCLE; LIGASE CHAIN-REACTION; NAVY ENLISTED WOMEN; LIFE-STYLE FACTORS; US ARMY SOLDIERS; PREMENOPAUSAL WOMEN AB In 1994, Congress provided $40M for biomedical research on issues of importance for military women. This supported 104 intramural and 30 extramural studies and launched an era of research to narrow the knowledge gap on protection and enhancement of health and performance of military women. Projects addressed issues specific to female physiology (e.g., gynecological health in the field, maternal malaria), problems with higher prevalence for women (e.g., marginal iron deficiency, stress fracture), and issues of drug and materiel safety that had only been extrapolated from studies of men (e.g., chemical agent prophylaxis, fatigue countermeasures). Several important assumptions about female physiology and occupational risks were found to be astoundingly wrong. Hormonal changes through the menstrual cycle were less important to acute health risks and performance than predicted, exercise did not increase risk for amenorrhea and consequent bone mineral loss, and women tolerated G-forces and could be as safe as men in the cockpit if their equipment was designed for normal size and strength ranges. Data on personal readiness issues, such as body fat, physical fitness, nutrition, and postpartum return to duty, allowed reconsideration of standards that were gender appropriate and not simply disconnected adjustments to existing male standards. Other discoveries directly benefited men as well as women, including development of medical surveillance databases, identification of task strength demands jeopardizing safety and performance, and greater understanding of the effects of psychosocial stress on health and performance. This surge of research has translated into advances for the welfare of service-women and the readiness of the entire force; relevant gender issues are now routine considerations for researchers and equipment developers, and some key remaining research gaps of special importance to military women continue to be investigated. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Friedl, KE (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM karl.friedl@us.army.mil OI Friedl, Karl/0000-0002-3134-8427 NR 161 TC 23 Z9 23 U1 1 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD NOV PY 2005 VL 14 IS 9 BP 764 EP 802 DI 10.1089/jwh.2005.14.764 PG 39 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 998VL UT WOS:000234347900002 PM 16313206 ER PT J AU Poliakov, EY Scalora, M Bloemer, MJ Zheltikov, AM AF Poliakov, EY Scalora, M Bloemer, MJ Zheltikov, AM TI A novel photonic crystal-based waveguide modulator SO LASER PHYSICS LA English DT Article ID INDEX OPTICAL FIBERS; INTENSITY MODULATOR; LIGHT; PROPAGATION; WAVEGUIDES; GUIDANCE; DIODE; LASER AB Using a beam propagation method, we propose a novel type of optical modulator, one which utilizes a photonic bandgap, structure. The device has a transverse, discontinuous index profile with transverse bandgaps. The modulator resembles a conventional Mach-Zehnder polymer-based device; however, its physical principles and operational characteristics are intrinsically different. The advantages of a specific layer arrangement within a waveguide are discussed in detail. We show that the conceptual device has low optical loss and a miniature size and that it is robust to structural variations. The coupling efficiency, material selection, and output characteristics are also discussed in the context of potential applications and experiments. C1 USA, Army Aviat & Missile Commond, AMSRD, WS,RD,ST, Redstone Arsenal, AL 35898 USA. Moscow MV Lomonosov State Univ, Dept Phys, Ctr Int Laser, Moscow 119899, Russia. RP Poliakov, EY (reprint author), USA, Army Aviat & Missile Commond, AMSRD, WS,RD,ST, Redstone Arsenal, AL 35898 USA. EM mscalora@ix.netcom.com NR 47 TC 3 Z9 3 U1 0 U2 1 PU INTERPERIODICA PI BIRMINGHAM PA PO BOX 1831, BIRMINGHAM, AL 35201-1831 USA SN 1054-660X J9 LASER PHYS JI Laser Phys. PD NOV PY 2005 VL 15 IS 11 BP 1599 EP 1606 PG 8 WC Optics; Physics, Applied SC Optics; Physics GA 986UU UT WOS:000233476000014 ER PT J AU Burgess, EB AF Burgess, EB TI After daybreak: The liberation of Bergen-Belsen, 1945. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS 66048 USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66048 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 1 PY 2005 VL 130 IS 18 BP 98 EP 98 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 031PV UT WOS:000236717400134 ER PT J AU VanLandingham, MR Juliano, TF Hagon, MJ AF VanLandingham, MR Juliano, TF Hagon, MJ TI Measuring tip shape for instrumented indentation using atomic force microscopy SO MEASUREMENT SCIENCE AND TECHNOLOGY LA English DT Article DE tip geometry; tip radius; tip angle; elastic modulus; hardness; atomic force microscope; instrumented nanoindenter; standards and calibration; indentation of compliant materials ID DEPTH-SENSING INDENTATION; AREA FUNCTION; NANOINDENTATION; GEOMETRY AB Atomic force microscopy (AFM) was used to determine the three-dimensional geometry of instrumented indentation probes. From the AFM image data, the cross-sectional area, A, was determined as a function of the distance, h(c), from the tip apex for a number of indentation probes, including Berkovich pyramidal tips and several rounded conical tip geometries. Nonlinear behaviour of the vertical AFM scanner caused significant uncertainties in the A (h(c)) data above a given image size, limiting the range of h(c) for accurate calibration to approximately 1 mu m. The A (h(c)) data averaged from multiple AFM images taken within this range were similar to the values determined from fused silica indentation. Deviations from the ideal tip shape were quantified by measuring the values of the tip radius and tip angle from the AFM images. Large deviations were observed for the rounded conical tips; for example, the values of the tip radius deviated from manufacturer values by 16% to 97%. In contrast, the Berkovich probes had tip angles within 4% of the ideal value (65.3 degrees) and with only minimal tip rounding (tip radius < 300 nm). This method is useful for characterizing indentation tips, particularly those with significant rounding, to larger contact depths than is possible using indentation of a reference material, which is important for probing compliant materials. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mark.vanlandingham@us.army.mil NR 15 TC 45 Z9 45 U1 2 U2 13 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-0233 EI 1361-6501 J9 MEAS SCI TECHNOL JI Meas. Sci. Technol. PD NOV PY 2005 VL 16 IS 11 BP 2173 EP 2185 DI 10.1088/0957-0233/16/11/007 PG 13 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 986MK UT WOS:000233453500008 ER PT J AU Robbins, DH Reddy, JN Rostam-Abadi, F AF Robbins, DH Reddy, JN Rostam-Abadi, F TI An efficient continuum damage model and its application to shear deformable laminated plates SO MECHANICS OF ADVANCED MATERIALS AND STRUCTURES LA English DT Article ID THERMOMECHANICAL CONSTITUTIVE THEORY; COMPOSITE-MATERIALS; DISTRIBUTED DAMAGE; ELASTIC COMPOSITES; SMART STRUCTURES; PREDICTION AB In this article an efficient 3-D continuum damage mechanics formulation for composite laminates and its implementation into a finite element model that is based on the first order shear deformation theory of laminates are described. In the damage formulation each composite ply is treated as a homogeneous orthotropic material that can exhibit orthotropic damage in the form of distributed microscopic cracks that are normal to the three principal material directions. This type of damage is efficiently described by a symmetric second order tensor field that serves as an evolving internal variable within the framework of irreversible thermodynamics. The damage tensor is continuous within each material ply of a given element, but can be discontinuous across material layer boundaries and inter-element boundaries. The resulting finite element formulation is shown to be robust, stable and efficient for the simulation of progressive damage and global failures in large-scale composite laminate problems. Numerical examples are provided to demonstrate the performance characteristics of the finite element model, which is shown to provide consistent results over a range of different element types, mesh densities, element distortion levels and element integration schemes. C1 Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. USA, Tank Automot & Armaments Command, Warren, MI USA. RP Robbins, DH (reprint author), Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. EM drobbins@eng.umd.edu RI Reddy, Junuthula/D-7737-2013 OI Reddy, Junuthula/0000-0002-9739-1639 NR 27 TC 12 Z9 12 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1537-6494 J9 MECH ADV MATER STRUC JI Mech. Adv. Mater. Struct. PD NOV-DEC PY 2005 VL 12 IS 6 BP 391 EP 412 DI 10.1080/15376490500259202 PG 22 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing; Materials Science, Composites SC Materials Science; Mechanics GA 972QN UT WOS:000232468400002 ER PT J AU Maskery, S Zhang, Y Hu, H Hooke, J Shriver, CD Liebman, M AF Maskery, S Zhang, Y Hu, H Hooke, J Shriver, CD Liebman, M TI Breast disease profiles in pre- and post-menopausal women SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY LA English DT Meeting Abstract CT 16th Annual Meeting of the North-American-Menopause-Society CY SEP 28-OCT 01, 2005 CL San Diego, CA SP N Amer Menopause Soc C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 1072-3714 J9 MENOPAUSE JI Menopause-J. N. Am. Menopause Soc. PD NOV-DEC PY 2005 VL 12 IS 6 BP 803 EP 803 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 986MM UT WOS:000233453700120 ER PT J AU Moul, JW AF Moul, JW TI Screening for prostate cancer in military populations SO MILITARY MEDICINE LA English DT Review ID AFRICAN-AMERICAN MEN; RADICAL RETROPUBIC PROSTATECTOMY; ANTIGEN LEVELS; REFERENCE RANGES; WHITE MEN; EXOGENOUS TESTOSTERONE; ENDOMETRIAL CANCERS; SOCIETY GUIDELINES; RADIATION-THERAPY; NG./ML. RANGE AB With the widespread use of the prostate-specific antigen (PSA) test, smaller cancers are being detected among younger men and 5-year, cancer-specific, survival rates are on the rise. Although this lead-time effect may not translate into long-term improvement, these changes are a necessary prerequisite to effective screening. For high-risk patients, i.e., men with a family history of the disease and African American men, a strategy consisting of annual PSA blood testing and digital rectal examination for men >= 40 years of age appears prudent. Many low/average-risk men of age 40 to 49 also request testing, and it is reasonable to offer testing and risk assessment to them. The exact screening threshold for total PSA levels for these men is not known, but 95% have PSA levels of <= 1.5 to 2.5 ng/mL. PSA velocity (< 20% per year), percentage of free PSA (> 18-25%), and complexed PSA levels may be used to help determine risk. More study of young men is needed. C1 Duke Univ, Med Ctr, Div Urol Surg, Durham, NC 27710 USA. Walter Reed Army Med Ctr, Urol Serv, Dept Surg, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Bethesda, MD 20814 USA. RP Moul, JW (reprint author), Duke Univ, Med Ctr, Div Urol Surg, Box 3707, Durham, NC 27710 USA. NR 103 TC 7 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2005 VL 170 IS 11 BP 905 EP 914 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 019JS UT WOS:000235832000001 PM 16450815 ER PT J AU Cohen, DJ Lisagor, P AF Cohen, DJ Lisagor, P TI Medical errors - Is total quality management for the battlefield desirable? SO MILITARY MEDICINE LA English DT Article ID ADVERSE EVENTS; HOSPITALIZED-PATIENTS; COLORADO; UTAH; CARE AB There has recently been a great deal of discussion in both the lay press as well as the medical press regarding the incidence of errors that occur during medical practice. There have been many discussions of how quality control measures from industry can be applied to the health care system. Indeed both civilian and "brick and mortar" military medical treatment facilities are adapting these techniques. It is important that we understand the principles behind Total Quality Management (TQM) as well as its techniques and limitations. TQM is based on limiting deviation from an accepted standard of practice. These principles may be as applicable to our military health care facilities in a field environment as they are to our fixed facilities, although the standards used for measurement may have to be modified to adapt to different constraints of environment and resources. TQM techniques can nonetheless be applied in virtually any facility to ensure the best possible care and outcomes for our soldiers. C1 USA, Directorate Combat & Doctrine Dev, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. Univ Nevada, Sch Med, Reno Vet Adm Hosp, Reno, NV 89439 USA. RP Cohen, DJ (reprint author), USA, Directorate Combat & Doctrine Dev, Med Dept Ctr & Sch, 1400 E Grayson St,Bldg 44, Ft Sam Houston, TX 78234 USA. EM david.j.cohen@us.army.mil NR 18 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2005 VL 170 IS 11 BP 915 EP 918 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 019JS UT WOS:000235832000002 PM 16450816 ER PT J AU Wood, SM Kennedy, JS Arsenault, JE Thomas, DL Buck, RH Shippee, RL DeMichele, SJ Winship, TR Schaller, JP Montain, S Cordle, CT AF Wood, SM Kennedy, JS Arsenault, JE Thomas, DL Buck, RH Shippee, RL DeMichele, SJ Winship, TR Schaller, JP Montain, S Cordle, CT TI Novel nutritional immune formula maintains host defense mechanisms SO MILITARY MEDICINE LA English DT Article ID DELAYED CUTANEOUS HYPERSENSITIVITY; RANDOMIZED CONTROLLED TRIAL; VITAMIN-E SUPPLEMENTATION; CELL-MEDIATED-IMMUNITY; RESPIRATORY-INFECTIONS; CYTOKINE PRODUCTION; PART 2; STRESS; ZINC; DEFICIENCY AB Military combat and training stress induce immune changes that increase the risk of infection and ultimately influence soldiers' performance and readiness. Strenuous military training/assessment provides a uniform stress and the opportunity to evaluate nutritional strategies to minimize stress-induced immune changes that predispose soldiers to infection. Immunological changes and effects of a novel nutritional immune formula (NNIF) were examined prospectively in a double-blind, controlled study of 200 soldiers attending Special Forces Assessment and Selection School. Immune function was measured by skin delayed-type hypersensitivity, lymphocyte phenotyping, mitogenic proliferative responses, and granulocyte function. Approximately 50% of soldiers completed the study (control, n = 57; NNIF, n = 50). Several stress-induced lymphocyte changes were observed (decreased mitogen-induced proliferation, T and total lymphocytes, and interferon-gamma-producing lymphocytes and increased percentage of neutrophils). NNIF modified several changes, including delayed-type hypersensitivity responses (NNIF, 78%; control, 59%; p < 0.05), increased proportions of helper T cells, activation of B cells, enhanced neutrophil phagocytosis, and attenuation of declines in certain functional subpopulations (i.e., cytotoxic/suppressor lymphocytes). Soldiers who consumed NNIF experienced less stress-induced immune impairment, thereby lowering the risk of infection. C1 Abbott Labs, Ross Prod Div, Columbus, OH 43215 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. Univ Massachusetts, Ctr Infect Dis & Vaccine Res, Sch Med, Worcester, MA 01655 USA. Theater Army Med Lab, Aberdeen Proving Ground, MD 21010 USA. RP Wood, SM (reprint author), 105670 RP3-2,625 Cleveland Ave, Columbus, OH 43215 USA. NR 57 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2005 VL 170 IS 11 BP 975 EP 985 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 019JS UT WOS:000235832000013 PM 16450827 ER PT J AU Helling, ER Pfannenstiel, TJ AF Helling, ER Pfannenstiel, TJ TI Comprehensive head and neck trauma screening: The USS Cole experience SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 51st Annual Symposium of the Society-of-Air-Force-Clinical-Surgeons CY APR 04-08, 2004 CL San Francisco, CA SP Soc Air Force Clin Surg ID BLAST INJURY; TYMPANIC MEMBRANE; AUDITORY-SYSTEM; WAR INJURIES AB A prospective study was designed to determine the incidence of occult head and neck injuries after initial triage of patients following the USS Cole terrorist bombing. All 39 patients evacuated to Landstuhl Regional Medical Center underwent comprehensive head and neck examinations, regardless of known diagnoses at the time of arrival. Appropriate interventions were performed, and detailed summaries were added to the patients' records. Initial triage listed nine of 39 patients as having sustained head and neck injuries. After screening by an otolaryngology team, 23 of 39 patients were identified as having head and neck injuries requiring further care. The majority of head and neck injuries were not initially reported to the head and neck trauma service. Our conclusion is that occult head and neck injuries are common after blast injuries. Early identification and intervention by a subspecialty head and neck trauma team can aid in achieving optimal outcomes after blast injury. C1 Landstuhl Reg Med Ctr, Dept Otolaryngol, APO, AE 09180 USA. Brooke Army Med Ctr, Dept Otolaryngol, Ft Sam Houston, TX 78234 USA. RP Helling, ER (reprint author), Landstuhl Reg Med Ctr, Dept Otolaryngol, APO, AE 09180 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2005 VL 170 IS 11 BP 991 EP 993 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 019JS UT WOS:000235832000015 PM 16450829 ER PT J AU Cui, LW Fan, Q Hu, Y Karamycheva, SA Quackenbush, J Khuntirat, B Sattabongkot, J Carlton, JM AF Cui, LW Fan, Q Hu, Y Karamycheva, SA Quackenbush, J Khuntirat, B Sattabongkot, J Carlton, JM TI Gene discovery in Plasmodium vivax through sequencing of ESTs from mixed blood stages SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE malaria parasite; blood stages; gene expression; EST; cDNA library; genomics ID MALARIA PARASITE; PROTEIN MSP-3-ALPHA; GENOME SEQUENCE; FALCIPARUM; IDENTIFICATION; PROTEASES; THAILAND; PATHWAY; FAMILY; TRANSCRIPTOME AB Despite the significance of Plasmodium vivax as the most widespread human malaria parasite and a major public health problem, gene expression in this parasite is poorly understood. To accelerate gene discovery and facilitate the annotation phase of the R vivax genome project, we have undertaken a transcriptome approach to study gene expression in the mixed blood stages of a P. vivax field isolate. Using a cDNA library constructed from purified blood stages, we have obtained single-pass sequences for approximately 21,500 expressed sequence tags (ESTs), the largest number of transcript tags obtained so far for this species. Cluster analysis revealed that the library is highly redundant, resulting in 5407 clusters. Clustered ESTs were searched against public protein databases for functional annotation, and more than one-third showed a significant match, the majority of these to Plasmodium falciparum proteins. The most abundant clusters were to genes encoding ribosomal proteins and proteins involved in metabolism, consistent with the predominance of trophozoites in the field isolate sample. In spite of the scarcity of other parasite stages in the field isolate, we could identify genes that are expressed in rings, schizonts and gametocytes. This study should facilitate our understanding of the gene expression in P. vivax asexual stages and provide valuable data for gene prediction and annotation of the P. vivax genome sequence. (c) 2005 Elsevier B.V. All rights reserved. C1 Penn State Univ, Dept Entomol, University Pk, PA 16802 USA. Inst Genom Res, Rockville, MD 20850 USA. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Cui, LW (reprint author), Penn State Univ, Dept Entomol, 501 ASI, University Pk, PA 16802 USA. EM luc2@psu.edu; carlton@tigr.org FU FIC NIH HHS [D43 TW006571] NR 77 TC 19 Z9 21 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD NOV PY 2005 VL 144 IS 1 BP 1 EP 9 DI 10.1016/j.molbiopara.2005.05.016 PG 9 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA 978BN UT WOS:000232847300001 PM 16085323 ER PT J AU Langston, JL Adkins, AL Moran, AV Rockwood, GA DeFord, MS AF Langston, JL Adkins, AL Moran, AV Rockwood, GA DeFord, MS TI Effects of sarin on the operant behavior of guinea pigs SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE sarin; GB; nerve agents; operant behavior; progressive ratio; guinea pigs ID SCHEDULE-CONTROLLED BEHAVIOR; ORGANOPHOSPHORUS NERVE AGENTS; LOW-LEVEL EXPOSURE; CHOLINESTERASE ACTIVITY; PYRIDOSTIGMINE BROMIDE; REPETITIVE INJECTION; SOMAN INTOXICATION; RATIO PERFORMANCE; PROGRESSIVE RATIO; SPECIES VARIATION AB The present study evaluated the dose-response effects of subacute exposure to sublethal doses of the organophosphorus (OP) chemical warfare nerve agent (CWNA) sarin (GB) on the operant behavior of guinea pigs. Dietary restricted guinea pigs, trained to respond for food under a progressive ratio (PR) schedule of reinforcement, were injected five times per week (Monday-Friday) for 2 weeks with fractions (0.1, 0.2, and 0.4) of the established LD50 of GB (42 mu g/kg), Changes in body weight, whole blood (WB) acetylcholinesterase (AChE) levels, and operant performances were monitored over the 2 weeks of GB exposure and for an additional 2 weeks following the termination of exposures. There were dose-related changes in body weight and WB AChE levels throughout the exposure and post-exposure periods. Several parameters of PR performance were disrupted during exposure to 0.4 LD50 GB, however, concurrent weight loss indicated the presence of overt toxicity. PR performance recovered following the termination of exposures. Lower doses (0.1 and 0.2 LD50) of GB failed to produce reliable effects on operant performance during the exposure period. Overall responding decreased during exposure to 0.4 LD50 GB, resulting in reduced response rates and break points. The decrease in overall response rates was attributed to an increase in pausing since there was no decrease in running rate. Motor effects of 0.4 LD50 GB were evident as an increase in the proportion of lever press durations >= 1.0 s. In the present study, doses of GB lower than 0.4 LD50 produced no marked alteration of operant performance in guinea pigs, although WB AChE levels were maximally inhibited to 20% of control. (c) 2005 Elsevier Inc. All rights reserved. C1 USA, Med Res Inst Chem Def, Drug Assessment Div, Aberdeen Proving Ground, MD 21010 USA. RP Langston, JL (reprint author), USA, Med Res Inst Chem Def, Drug Assessment Div, 3100 Ricketts Point Rd MCMR-UV-DA, Aberdeen Proving Ground, MD 21010 USA. EM Jeffrey.Langston@us.army.mil NR 89 TC 6 Z9 6 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD NOV-DEC PY 2005 VL 27 IS 6 BP 841 EP 853 DI 10.1016/j.ntt.2005.06.015 PG 13 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 990TZ UT WOS:000233767400007 PM 16046097 ER PT J AU Byers, BD Gordon, MC Higby, K AF Byers, BD Gordon, MC Higby, K TI Severe hemolytic disease of the newborn due to anti-Cw SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT Meeting of the Armed Forces District of the American-College-of-Obstetricians-and-Gynecologists CY OCT 17-20, 2004 CL San Diego, CA SP Amer Coll Obstet & Gynecologists, Armed Forces Dist ID ALLOIMMUNIZATION; MANAGEMENT AB BACKGROUND: Pregnancies complicated by Rh isoimmunization have decreased significantly since the widespread use of Rh immune globulin. Uncommon red blood cell antigens have therefore become more clinically evident. We report a case of anti-Cw immunization that resulted in severe fetal anemia that required multiple transfusions. CASE: A 28-year-old multigravida presented to our service at 18 weeks of gestation with her fourth pregnancy. Her pregnancy was complicated by anti-Cw isoimmunization that resulted in severe fetal anemia requiring in utero fetal blood transfusions. CONCLUSION: While previous reports recommend only postpartum surveillance when Cw isoimmunization is present, we report a case resulting in severe fetal anemia. C1 Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. RP Byers, BD (reprint author), 826 Washington St,Suite 202, Watertown, NY 13601 USA. EM Benjamin.byers@sbcglobal.net NR 8 TC 5 Z9 5 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD NOV PY 2005 VL 106 IS 5 BP 1180 EP 1182 DI 10.1097/01.AOG.0000164060.89842.a9 PN 2 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 980LB UT WOS:000233018900016 PM 16260563 ER PT J AU Joseph, KR Richards, KC Rotenberg, JS AF Joseph, KR Richards, KC Rotenberg, JS TI Rash, fever, and neck pain in the office: Is this a neurologic emergency? SO PEDIATRIC ANNALS LA English DT Article ID ANTICONVULSANT HYPERSENSITIVITY SYNDROME; INDUCED MOVEMENT-DISORDERS; STEVENS-JOHNSON-SYNDROME; STATUS EPILEPTICUS; SEROTONIN SYNDROME; INTRATHECAL BACLOFEN; CHILDREN; MANAGEMENT; SEIZURES; LAMOTRIGINE C1 Walter Reed Army Med Ctr, Dept Neurol, Child & Adolescent Neurol Serv, Washington, DC 20307 USA. Wilford Hall USAF Med Ctr, Pediat Neurol & Epilepsy Serv, Lackland AFB, TX USA. Div Sleep Med, San Antonio, TX USA. San Antonio Mil Pediat Ctr, San Antonio, TX USA. RP Joseph, KR (reprint author), Walter Reed Army Med Ctr, Dept Neurol, Child & Adolescent Neurol Serv, Bldg 2 Room 1L,6900 Georgia NW, Washington, DC 20307 USA. EM kevin.joseph@na.amedd.army.mil NR 27 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0090-4481 J9 PEDIATR ANN JI Pediatr. Annu. PD NOV PY 2005 VL 34 IS 11 BP 878 EP 884 PG 7 WC Pediatrics SC Pediatrics GA 981XE UT WOS:000233120500007 PM 16353649 ER PT J AU Clark, P Ruess, L AF Clark, P Ruess, L TI Counterclockwise barber-pole sign on CT: SMA/SMV variance without midgut malrotation SO PEDIATRIC RADIOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the Society-for-Pediatric-Radiology CY MAY, 2005 CL New Orleans, LA SP Soc Pediat Radiol DE malrotation; midgut volvulus; barber-pole sign; CT; variance ID WHIRLPOOL SIGN; VOLVULUS; DIAGNOSIS AB We report on a 10-year-old girl who presented with worsening pain and anorexia after blunt trauma to the abdomen. Contrast-enhanced CT of the abdomen was performed, and a counterclockwise rotation of the superior mesenteric vein around the superior mesenteric artery was seen. An upper gastrointestinal (UGI) series with small-bowel follow-through demonstrated a normally located duodenal-jejunal junction. This is the first case report of a counterclockwise barber-pole sign seen by CT with UGI that was negative for malrotation or volvulus. C1 Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Radiol & Radiol Sci & Pediat, Bethesda, MD 20814 USA. Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Ruess, L (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Radiol & Radiol Sci & Pediat, Bethesda, MD 20814 USA. EM lynne.ruess@amedd.army.mil NR 5 TC 8 Z9 10 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD NOV PY 2005 VL 35 IS 11 BP 1125 EP 1127 DI 10.1007/s00247-005-1517-4 PG 3 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA 973NZ UT WOS:000232531200016 PM 15931517 ER PT J AU Britt, TW Castro, CA Adler, AB AF Britt, TW Castro, CA Adler, AB TI Self-engagement, stressors, and health: A longitudinal study SO PERSONALITY AND SOCIAL PSYCHOLOGY BULLETIN LA English DT Article DE engagement; stress; buffer; motivation; stressor; performance ID JOB STRESS; PSYCHOLOGICAL CONDITIONS; TRIANGLE MODEL; WORK; RESPONSIBILITY; PERFORMANCE; HARDINESS; ILLNESS; WELL AB The authors examined whether engagement in a performance domain could buffer or exacerbate the consequences of different stressors. Soldiers completed measures of engagement in work, work demands (days training, work hours, and subjective work. overload), and symptoms at two time periods. Engagement in work interacted with days training and work hours at Time 1 to Predict health symptoms at Time 2 (after controlling Time 1 outcomes). Soldiers highly engaged in their jobs were less likely to report negative consequences under high levels of training/work hours in comparison to soldiers disengaged from their jobs. However, engagement in work into-acted with work overload in the opposite manner, with high levels of engagement potentiating the relationship between overload and reports of health symptoms. Engagement in a domain appears to buffer individuals from stressors that do not undermine performance but may exacerbate the impact of stressors that compromise Performing well in the domain. C1 Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. Walter Reed Army Inst Res, Washington, DC 20307 USA. RP Britt, TW (reprint author), Clemson Univ, Dept Psychol, 418 Brackett Hall, Clemson, SC 29634 USA. EM twbritt@clemson.edu NR 46 TC 35 Z9 39 U1 5 U2 17 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0146-1672 J9 PERS SOC PSYCHOL B JI Pers. Soc. Psychol. Bull. PD NOV PY 2005 VL 31 IS 11 BP 1475 EP 1486 DI 10.1177/0146167205276525 PG 12 WC Psychology, Social SC Psychology GA 011YO UT WOS:000235305600002 PM 16207767 ER PT J AU Clayton, JD Bammann, DJ McDowell, DL AF Clayton, JD Bammann, DJ McDowell, DL TI A geometric framework for the kinematics of crystals with defects SO PHILOSOPHICAL MAGAZINE LA English DT Article; Proceedings Paper CT 40th Annual Technical Meeting of the Society-of-Engineering-Science CY OCT 12-15, 2003 CL Ann Harbor, MI ID NONLINEAR CONTINUUM THEORY; TILT GRAIN-BOUNDARIES; CONTINUOUS DISTRIBUTIONS; CONFIGURATIONAL FORCES; EDGE DISLOCATION; SINGLE-CRYSTALS; LATTICE-DEFECTS; GRADIENT THEORY; GAUGE-THEORY; PLASTICITY AB Presented is a general theoretical framework capable of describing the finite deformation kinematics of several classes of defects prevalent in metallic crystals. Our treatment relies upon powerful tools from differential geometry, including linear connections and covariant differentiation, torsion, curvature an anholonomic spaces. A length scale dependent, three-term multiplicative decomposition of the deformation gradient is suggested, with terms representing recoverable elasticity, residual lattice deformation due to defect fields, and plastic deformation resulting from defect fluxes. Also proposed is an additional micromorphic variable representing additional degrees-of-freedom associated, point defects, and most with rotational lattice defects (i.e. disclinations). generally, Somigliana dislocations. We illustrate how particular implementations of our general framework encompass notable theories from the literature and classify particular versions of the framework via geometric terminology. C1 USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. Sandia Natl Labs, Dept Sci Based Mat Modeling, Livermore, CA 94550 USA. Georgia Inst Technol, GWW, Sch Mech Engn, Atlanta, GA 30332 USA. RP Clayton, JD (reprint author), USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 NR 102 TC 36 Z9 36 U1 0 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1478-6435 J9 PHILOS MAG JI Philos. Mag. PD NOV-DEC PY 2005 VL 85 IS 33-35 BP 3983 EP 4010 DI 10.1080/14786430500363312 PG 28 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter SC Materials Science; Metallurgy & Metallurgical Engineering; Physics GA 000RW UT WOS:000234481100008 ER PT J AU Duffy, PE Mutabingwa, TK AF Duffy, PE Mutabingwa, TK TI Rolling back a malaria epidemic in South Africa SO PLOS MEDICINE LA English DT Editorial Material ID FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; ARTEMETHER; COMBINATION; RESISTANCE; BURDEN C1 Biomed Res Inst, Seattle, WA USA. Walter Reed Army Inst Res, Silver Spring, MD USA. London Sch Hyg & Trop Med, London WC1, England. Natl Inst Med Res, Dar Es Salaam, Tanzania. RP Duffy, PE (reprint author), Biomed Res Inst, Seattle, WA USA. EM patrick.duffy@sbri.org NR 13 TC 1 Z9 2 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD NOV PY 2005 VL 2 IS 11 BP 1076 EP 1077 AR e368 DI 10.1371/journal.pmed.0020368 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 998FC UT WOS:000234303000015 PM 16187736 ER PT J AU Brandt, HE AF Brandt, Howard E. TI Unambiguous state discrimination in quantum key distribution SO QUANTUM INFORMATION PROCESSING LA English DT Article DE quantum cryptography; quantum key distribution; quantum communication; quantum computer; entanglement ID CRYPTOGRAPHY; INFORMATION AB The quantum circuit and design are presented for an optimized entangling probe attacking the BB84 Protocol of quantum key distribution (QKD) and yielding maximum information to the probe. Probe photon polarization states become optimally entangled with the signal states on their way between the legitimate transmitter and receiver: Although standard von-Neumann projective measurements of the probe yield maximum information on the pre-privacy amplified key, if instead the probe measurements are performed with a certain positive operator valued measure (POVM), then the measurement results are unambiguous, at least some of the time. It follows that the BB84 (Bennett-Brassard 1984) protocol of quantum key distribution has a vulnerability similar to the well-known vulnerability of the B92 (Bennett 1992) protocol. C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM hbrandt@arl.army.mil NR 19 TC 9 Z9 9 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1570-0755 J9 QUANTUM INF PROCESS JI Quantum Inf. Process. PD NOV PY 2005 VL 4 IS 5 BP 387 EP 398 DI 10.1007/s11128-005-0003-0 PG 12 WC Physics, Multidisciplinary; Physics, Mathematical SC Physics GA 098VE UT WOS:000241550100002 ER PT J AU Lettieri, CJ Veerappan, GR Parker, JM Franks, TJ Hayden, D Travis, WD Shorr, AF AF Lettieri, CJ Veerappan, GR Parker, JM Franks, TJ Hayden, D Travis, WD Shorr, AF TI Discordance between general and pulmonary pathologists in the diagnosis of interstitial lung disease SO RESPIRATORY MEDICINE LA English DT Editorial Material DE biopsy; histopathology; idiopathic pulmonary fibrosis; interstitial lung disease ID QUANTITATIVE ASSESSMENT; FIBROSIS; BIOPSY AB Background: Interstitial lung diseases (ILDs) often present diagnostic challenges to both the clinician and pathologist. Surgical lung biopsy (SLB) is often pursued in the evaluation of ILD and the clinician uses the histopathotogic conclusions to guide management. However, the agreement between general and pulmonary pathologists in histopathologic diagnosis of ILD has not been established. Objective: To determine the agreement between general and pulmonary pathologists in the histopathotogic interpretation of ILDs and whether disagreements result in changes in clinical management. Methods: We retrospectively reviewed all patients who underwent SLB for ILD at our institution, between 1996 and 2002. We compared the interpretations of general pathologists to those of pulmonary pathologists to evaluate the degree of inter-rater agreement. We assumed the specialist pathologist represented the "gold standard." We further determined if changes in the histopathotogic diagnosis altered clinical management. Results: Of 83 subjects who underwent SLB, 44 (mean age 58.5 +/- 14.2, 47.7% mate) were examined by both general and specialty pathologists. There was poor agreement between the two sets of reviewers. The histopathologic interpretation by the specialist pathologist differed from the generalist in 52.3% of cases (kappa 0.21, P<0.0001). This high rate of discordance led to frequent (60.0%) changes in clinical management. As a screening test for usual interstitial pneumonia, the observations of the general pathologist had moderate sensitivity and specificity (76.5% and 66.7%, respectively). Conclusions: General and pulmonary pathologists often differ in their interpretation of the histopathology in ILD. This significant discordance may have important clinical implications for patient care. (c) 2005 Elsevier Ltd. All rights reserved. C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Armed Forces Inst Pathol, Dept Pulm & Mediastinal Pathol, Washington, DC 20306 USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.letteri@us.army.mil NR 12 TC 27 Z9 27 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0954-6111 J9 RESP MED JI Respir. Med. PD NOV PY 2005 VL 99 IS 11 BP 1425 EP 1430 DI 10.1016/j.rmed.2005.03.008 PG 6 WC Cardiac & Cardiovascular Systems; Respiratory System SC Cardiovascular System & Cardiology; Respiratory System GA 977QV UT WOS:000232819200010 PM 16210097 ER PT J AU Klinedinst, DB Yilgor, E Yilgor, I Beyer, FL Sheth, JP Wilkes, GL AF Klinedinst, DB Yilgor, E Yilgor, I Beyer, FL Sheth, JP Wilkes, GL TI Structure - Property behavior of new segmented polyurethanes and polyureas without use of chain extenders SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article; Proceedings Paper CT Annual Spring Meeting of the Rubber-Division-of-the-American-Chemical-Society CY MAY 16-18, 2005 CL San Antonio, TX SP Amer Chem Soc, Rubber Div ID BIS(SILYL PINACOLATE) GROUPS; BONDED POLYMER BLENDS; GLYCOL) SOFT SEGMENTS; VINYL BLOCK POLYMERS; ANGLE X-RAY; MOLECULAR-WEIGHT; POLYDIMETHYLSILOXANE MACROINITIATORS; MICROPHASE SEPARATION; UREA COPOLYMERS; CO-POLYMERS AB New novel segmented polyurethane and polyurea copolymers have been synthesized without chain extenders and the structure-property behavior of these systems has been investigated. It is shown that by the proper choice of diisocyanate and its symmetry, one can obtain highly microphase separated systems without chain extenders and that the materials also display useful mechanical behavior. In particular, it is shown that due to the bidentate hydrogen bonding achieved in the segmented ureas, a significant modulus "service temperature window" is also obtained. It is also verified that not only can strong microphase separation be obtained with low weight fraction hard segment content (14%) but that the hard phase, which is comprised of monodisperse "single molecule" units, also displays a percolated thread-like structure throughout the dominant soft segment material - the latter being based on ca. 1000 g/mol polytetramethylene oxide. C1 Virginia Polytech Inst & State Univ, Dept Chem Engn, Blacksburg, VA 24061 USA. Virginia Polytech Inst & State Univ, Dept Mat Sci & Engn, Blacksburg, VA 24061 USA. Koc Univ, Dept Chem, TR-34450 Istanbul, Turkey. USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Wilkes, GL (reprint author), Virginia Polytech Inst & State Univ, Dept Chem Engn, Blacksburg, VA 24061 USA. EM gwilkes@vt.edu RI He, Yong/F-8752-2012 NR 51 TC 24 Z9 24 U1 6 U2 12 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 USA SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD NOV-DEC PY 2005 VL 78 IS 5 BP 737 EP 753 DI 10.5254/1.3547910 PG 17 WC Polymer Science SC Polymer Science GA 001PN UT WOS:000234548900001 ER PT J AU Handrigan, MT Burns, AR Donnachie, EM Bowden, RA AF Handrigan, MT Burns, AR Donnachie, EM Bowden, RA TI Hydroxyethyl starch inhibits neutrophil adhesion and transendothelial migration SO SHOCK LA English DT Article DE resuscitation; fluid; hetastarch; hydroxyethyl starch; hemorrhage; immune; activation; migration ID TRAUMA-HEMORRHAGIC-SHOCK; P-SELECTIN; FLUID RESUSCITATION; CHEMOTACTIC FACTORS; MESENTERIC LYMPH; ENDOTOXIC RATS; ACTIVATION; EXPRESSION; INJURY; SEQUESTRATION AB A resuscitation strategy that significantly alters the state of neutrophil (PMN) activation may impact organ function and survivability after shock. Various resuscitative fluids have been shown to elicit a severe immune activation and an upregulation of cellular injury markers, whereas other fluids have been shown to be protective. Recent studies have demonstrated that hydroxyethyl starch (HES), an artificial colloid, may exert significant anti-inflammatory effects, whereas conflicting studies with the same substance have shown an increase in PMN activation. Successful manipulation of the early immune events associated with hemorrhage and resuscitation will require a better understanding of the possible pro- or anti-inflammatory effects of resuscitation fluids. Our study investigated the effect of HES directly on PMN and cultured vascular endothelial cells in vitro, The effect of HES on PMN surface expression of CD11b and L-selectin was measured by flow cytometry. PMN activation response to HES was measured using a shape-change assay in response to formyl-methionyl-leucyl-phenylalanine (f-MLP). The effect of HES on endothelial cell surface expression of E-selectin, P-selectin, vascular cell adhesion molecule-l(VCAM-1), and intracellular adhesion molecule-1 (ICAM-1) was evaluated by enzyme-linked immunoabsorbant assay. PMN rolling, adhesion, and migration events were measured using direct microscopy under conditions simulating microvascular flow. PMN surface expression of CD11b and L-selectin in whole blood samples and isolated PMNs were unaffected by exposure to HES. HES had no effect on the normal f-MLP dose-dependent increase in PMN activation. In the absence of IL-1 stimulation, there was a small but statistically significant (P < 0.05) increase in ICAM-1 after exposure to HES. After stimulation with IL-1 (10 U/mL), HES had no effect on the expression of P-selectin, E-selectin, ICAM-1, or VCAM-1. Under simulated microvascular flow conditions in vitro, HES significantly diminished the PMN tethering rate (P < 0.05) and the transendothelial migration rate (P < 0.05) in a dose-dependent manner. HES significantly alters the function of the PMN at the interface of the PMN responding to activated endothelium. The effect occurs, surprisingly, without a coincident effect on the state of PMN activation or a significant change in the surface expression of the adhesion molecules responsible for PMN-endothelial interaction. C1 Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD 20910 USA. Baylor Coll Med, Sect Leukocyte Biol, Houston, TX 77030 USA. US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Handrigan, MT (reprint author), Walter Reed Army Inst Res, Div Mil Casualty Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM handriganm.ctr@nmrc.navy.mil FU NHLBI NIH HHS [HL-070537, HL-42550]; NIAID NIH HHS [AI-46773] NR 36 TC 27 Z9 35 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 1073-2322 J9 SHOCK JI Shock PD NOV PY 2005 VL 24 IS 5 BP 434 EP 439 DI 10.1097/01.shk.0000180625.53800.63 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 981YH UT WOS:000233123400007 PM 16247329 ER PT J AU Freccero, D Donovan, DJ AF Freccero, D Donovan, DJ TI Adjacent segment degeneration at T1-T2 presenting as chest pain - Case report SO SPINE LA English DT Article DE herniated disc; thoracic; adjacent segment degeneration ID HERNIATED THORACIC DISKS; RADICULOPATHY AB Study Design. A case report of a T1 - T2 herniated disc adjacent to a cervical spine fusion. Objective. To describe the clinical presentation and treatment of a symptomatic T1 - T2 disc herniation adjacent to an anterior cervical spine arthrodesis. Summary of Background Data. Symptomatic adjacent segment disease after cervical spine arthrodesis occurs most commonly in the lower cervical spine motion segments and has not been previously reported at T1 - T2. Methods. A 51-year-old female patient presented 4 years after three-level anterior cervical discectomy and fusion involving the C5 - T1 levels. She complained of chronic chest pain and had undergone extensive medical evaluation before presentation. Magnetic resonance imaging revealed a left-sided T1 - T2 herniated disc compressing the T1 nerve root. She underwent T1 - T2 anterior discectomy and fusion. Results. The patient's symptoms resolved completely. Conclusion. Adjacent-segment degeneration after cervical spine fusion may rarely occur even at T1 - T2, and the unusual symptoms of a T1 radiculopathy may obscure the diagnosis. The combination of sharp anterior paramedian chest pain and numbness or weakness of the hand should prompt consideration of the diagnosis when cardiac ischemia or other more serious conditions have been ruled out. C1 Tripler Army Med Ctr, Dept Surg, Orthopaed Surg Serv, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Surg, Neurosurg Serv, Honolulu, HI 96859 USA. RP Freccero, D (reprint author), Tripler Army Med Ctr, Dept Surg, Orthopaed Surg Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM dfreccero@aol.com NR 18 TC 5 Z9 5 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0362-2436 J9 SPINE JI SPINE PD NOV 1 PY 2005 VL 30 IS 21 BP E655 EP E657 DI 10.1097/01.brs.0000184304.46809.45 PG 3 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 980KE UT WOS:000233016600027 PM 16261104 ER PT J AU Hwang, S Ruff, TJ Bouwer, EJ Larson, SL Davis, JL AF Hwang, S Ruff, TJ Bouwer, EJ Larson, SL Davis, JL TI Applicability of alkaline hydrolysis for remediation of TNT-contaminated water SO WATER RESEARCH LA English DT Article DE alkaline hydrolysis; batch reactors; continuous flow stirred-tank reactor; 2; 4; 6-trinitrotoluene ID AQUEOUS-SOLUTION; 1,3,5-TRIAZA-1,3,5-TRINITROCYCLOHEXANE; 2,4,6-TRINITROTOLUENE; KINETICS; RDX AB This study was conducted to assess the applicability of alkaline hydrolysis as an alternative ex situ technology for remediating 2,4,6-trinitrotoluene (TNT)-contaminated water. TNT reactivity had a strong dependence on the reaction pH (11-12) and initial TNT (5-25 mg L-1) in batch systems, resulting in pseudo first-order transformation rate, k ranging between 1.9 x 10(-3) and 9.3 x 10(-5) min(-1). In continuous flow stirred-tank reactor (CFSTR) systems with initial TNT of 1 mg L-1, the highest 74% of TNT reduction was achieved at the reaction pH of 11.9 and 2-day hydraulic retention time under steady-state condition. Oxalate was produced as the major hydrolysate in the CFSTRs, indicating a ring cleavage during alkaline hydrolysis. It was also believed that TNT alkaline hydrolysis occurred through the production of color-forming intermediates via dimerization. It is concluded that alkaline hydrolysis can be an alternative treatment technology for remediation of TNT-contaminated water. (c) 2005 Elsevier Ltd. All rights reserved. C1 Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR 00680 USA. Mississippi State Univ, Dept Chem Engn, Mississippi State, MS 39762 USA. Johns Hopkins Univ, Dept Geog & Environm Engn, Baltimore, MD 21218 USA. USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Hwang, S (reprint author), Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR 00680 USA. EM shwang@uprm.edu RI Bouwer, Edward/A-3287-2010 NR 18 TC 10 Z9 11 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD NOV PY 2005 VL 39 IS 18 BP 4503 EP 4511 DI 10.1016/j.watres.2005.09.008 PG 9 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 986TX UT WOS:000233473700026 PM 16236339 ER PT J AU Ferrick, MG AF Ferrick, MG TI Simple wave and monoclinal wave models: River flow surge applications and implications SO WATER RESOURCES RESEARCH LA English DT Article AB Unsteady flow surges in rivers can be idealized as a transition between lower steady flow downstream and higher steady flow upstream. Simple wave and monoclinal wave models are analytical solutions of the dynamic wave equations that can be used to model these surges. The simple wave model neglects bed slope and flow resistance, simulating surge propagation over relatively short distances. The monoclinal wave profile evolves progressively, and this model is generally applicable at larger distances. These models are easy to use and generally apply to different flow conditions. However, both models lack criteria to determine their suitability for specific applications. The objectives of this paper are to develop and to assess criteria to guide simple wave and monoclinal wave model applications and to use the models to gain insights into the inertia and slope-flow resistance contributions to momentum and the nonlinear effects of increasing surge amplitude. Simple wave model application criteria include a dimensionless time, the amplitude to initial amplitude ratio for a linear dynamic wave traveling downstream, a distance scale, and the ratio between the measured surge celerity and the c(+) dynamic wave celerity of the high flow upstream. The length of the monoclinal-diffusion wave profile gives the minimum distance needed to develop a steady monoclinal wave profile. Model capabilities to describe flow surges and the adequacy of the application criteria are evaluated with data from laboratory and field studies covering a wide range of conditions. Profile celerity and high flow velocity behind the surge are always greater for the simple wave than for the monoclinal wave because of the absence of slope and flow resistance effects. The differences between the models are enhanced as Froude number decreases and as surge amplitude increases. C1 USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Ferrick, MG (reprint author), USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM michael.g.ferrick@erdc.usace.army.mil NR 22 TC 4 Z9 4 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD NOV 1 PY 2005 VL 41 IS 11 AR W11402 DI 10.1029/2004WR003923 PG 19 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 982NB UT WOS:000233164100002 ER PT J AU Chapin, FS Sturm, M Serreze, MC McFadden, JP Key, JR Lloyd, AH McGuire, AD Rupp, TS Lynch, AH Schimel, JP Beringer, J Chapman, WL Epstein, HE Euskirchen, ES Hinzman, LD Jia, G Ping, CL Tape, KD Thompson, CDC Walker, DA Welker, JM AF Chapin, FS Sturm, M Serreze, MC McFadden, JP Key, JR Lloyd, AH McGuire, AD Rupp, TS Lynch, AH Schimel, JP Beringer, J Chapman, WL Epstein, HE Euskirchen, ES Hinzman, LD Jia, G Ping, CL Tape, KD Thompson, CDC Walker, DA Welker, JM TI Role of land-surface changes in Arctic summer warming SO SCIENCE LA English DT Article ID CLIMATE-CHANGE; ENVIRONMENTAL-CHANGE; SEWARD PENINSULA; NORTHERN ALASKA; CARBON STORAGE; TUNDRA SOILS; VEGETATION; TRENDS; TEMPERATURE; TREELINE AB A major challenge in predicting Earth's future climate state is to understand feedbacks that alter greenhouse-gas forcing. Here we synthesize field data from arctic Alaska, showing that terrestrial changes in summer albedo contribute substantially to recent high-latitude warming trends. Pronounced terrestrial summer warming in. arctic Alaska correlates with a lengthening of the snow-free season that has increased atmospheric heating locally by about 3 watts per square meter per decade (similar in magnitude to the regional heating expected over multiple decades from a doubling of atmospheric CO2). The continuation of current trends in shrub and tree expansion could further amplify this atmospheric heating by two to seven times. C1 Univ Alaska, Inst Arctic Biol, Fairbanks, AK 99775 USA. Univ Alaska, US Geol Survey, Fairbanks, AK 99775 USA. Univ Alaska, Alaska Cooperat Fish & Wildlife Res Unit, Fairbanks, AK 99775 USA. Univ Alaska, Dept Forest Sci, Fairbanks, AK 99775 USA. Univ Alaska, Inst No Engn, Fairbanks, AK 99775 USA. USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. Univ Minnesota, Dept Ecol Evolut & Behav, St Paul, MN 55108 USA. NOAA, Natl Environm Satellite Data & Informat Serv, Madison, WI 53706 USA. Middlebury Coll, Dept Biol, Middlebury, VT 05443 USA. Monash Univ, Sch Geog & Environm Sci, Clayton, Vic 3800, Australia. Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA. Univ Illinois, Dept Atmospher Sci, Urbana, IL 61801 USA. Univ Virginia, Dept Environm Sci, Charlottesville, VA 22904 USA. Colorado State Univ, Dept Forest Rangeland & Watershed Stewardship, Ft Collins, CO 80523 USA. Univ Alaska Fairbanks, Palmer Res Stn, Palmer, AK 99645 USA. Univ Alaska Anchorage, Environm & Nat Resources Inst, Anchorage, AK 99501 USA. RP Chapin, FS (reprint author), Univ Alaska, Inst Arctic Biol, Fairbanks, AK 99775 USA. EM terry.chapin@uaf.edu RI Key, Jeffrey/F-5597-2010; Hinzman, Larry/B-3309-2013; Welker, Jeffrey/C-9493-2013; Beringer, Jason/B-8528-2008; Lynch, Amanda/B-4278-2011 OI Key, Jeffrey/0000-0001-6109-3050; Hinzman, Larry/0000-0002-5878-6814; Beringer, Jason/0000-0002-4619-8361; Chapin III, F Stuart/0000-0002-2558-9910; Lynch, Amanda/0000-0003-2990-1016 NR 48 TC 617 Z9 645 U1 25 U2 286 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 EI 1095-9203 J9 SCIENCE JI Science PD OCT 28 PY 2005 VL 310 IS 5748 BP 657 EP 660 DI 10.1126/science.1117368 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 980ET UT WOS:000232997700036 PM 16179434 ER PT J AU Kirk, AD Mannon, RB Kleiner, DE Swanson, JS Kampen, RL Cendales, LK Elster, EA Wakefield, T Chamberlain, C Hoffmann, SC Hale, DA AF Kirk, AD Mannon, RB Kleiner, DE Swanson, JS Kampen, RL Cendales, LK Elster, EA Wakefield, T Chamberlain, C Hoffmann, SC Hale, DA TI Results from a human renal allograft tolerance trial evaluating T-cell depletion with alemtuzumab combined with deoxyspergualin SO TRANSPLANTATION LA English DT Article DE alemtuzumab; deoxyspergualin; immunosuppression; rejection; tolerance; transplantation ID KIDNEY-TRANSPLANTATION; HEART ALLOGRAFTS; PANCREAS-KIDNEY; INDUCTION; MONOTHERAPY; IMMUNOSUPPRESSION; UNRESPONSIVENESS; PERITRANSPLANT; IMMUNOTOXIN; CAMPATH-1H AB Background. Perioperative lymphocyte depletion induces allograft tolerance in some animal models, but in humans has only been shown to reduce immunosuppressive requirements. Without maintenance immunosuppression, depleted human renal allograft recipients experience rejection characterized by infiltration of the allograft with monocytes and macrophages. T-cell depletion combined with a brief course of deoxyspergualin (DSG), a drug with inhibitory effects on monocytes and macrophages, induces tolerance in nonhuman primates. We therefore performed a trial to determine if lymphocyte depletion with alemtuzumab combined with DSG would induce tolerance in humans. Methods. Five recipients of live donor kidneys were treated perioperatively with alemtuzumab and DSG and followed postoperatively without maintenance immunosuppression. Patients were evaluated clinically, by flow cytometry, and by protocol biopsies analyzed immunohistochemically and with real-time polymerase chain reaction. Results were compared to previously studied patients receiving alemtuzumab alone or standard immunosuppression. Results. Despite profound T-cell depletion and therapeutic DSG dosing, all alemtuzumab/DSG patients developed reversible rejection that was similar in timing, histology, and transcriptional profile to that seen in patients treated with alemtuzumab alone. Chemokine expression was marked prior to and during rejections. Conclusions. We conclude that treatment with alemtuzumab and DSG does not induce tolerance in humans. Chemokine production may not be adequately suppressed using this approach. C1 NIDDKD, Transplantat Branch, NIH, Bethesda, MD 20892 USA. NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. RP Kirk, AD (reprint author), Room 5-5752,Bldg 10,Ctr Dr, Bethesda, MD 20892 USA. EM allank@intra.niddk.nih.gov RI Kirk, Allan/B-6905-2012; OI Kleiner, David/0000-0003-3442-4453 NR 20 TC 88 Z9 92 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD OCT 27 PY 2005 VL 80 IS 8 BP 1051 EP 1059 DI 10.1097/01.tp.0000174341.49741.8f PG 9 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 985KF UT WOS:000233375600009 PM 16278585 ER PT J AU Adams, BD Anderson, PI Stuffel, E AF Adams, BD Anderson, PI Stuffel, E TI Cardiac arrest of visitors in a hospital public area: Bystander AED is faster than standard cardiac arrest team SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 81 BP U1195 EP U1196 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956406358 ER PT J AU Eckart, RE Scoville, SL Shry, EA Potter, RN Tedrow, U AF Eckart, RE Scoville, SL Shry, EA Potter, RN Tedrow, U TI Sudden death in young women - A study of 850,000 female military recruits SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 Brigham & Womens Hosp, Boston, MA 02115 USA. USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. USA Med Command, Ft Sam Houston, TX USA. Armed Forces Inst Pathol, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 40 BP U1187 EP U1187 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956406317 ER PT J AU Freeman, JE Panasyuk, SV Lew, RA Holcomb, JB Hopmeier, MJ Esther, M Cooke, WH Victor, CA AF Freeman, JE Panasyuk, SV Lew, RA Holcomb, JB Hopmeier, MJ Esther, M Cooke, WH Victor, CA TI Diagnosis and evaluation of human hemodynamic compromise using Medical Hyperspectral Imaging (MHSI) as a stand-off non-invasive method SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 HyperMed Inc, Weston, MA USA. USA, Inst Surg Res, San Antonio, TX USA. Unconvent Concepts Inc, Mary Esther, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 45 BP U1188 EP U1188 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956406322 ER PT J AU Jezior, MR Kowalczyk, JR Brundage, JF Simpson, DE AF Jezior, MR Kowalczyk, JR Brundage, JF Simpson, DE TI Incidence of cardiac events among US armed forces service members before and after the terrorist attacks of September 11th 2001 SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Army Med Surveillance Activ, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 3589 BP U837 EP U837 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956405257 ER PT J AU Panasyuk, SV Freeman, J Lew, RA Tracey, B Jordan, BS Batchinsky, AI Hopmeier, MJ Cancio, LC AF Panasyuk, SV Freeman, J Lew, RA Tracey, B Jordan, BS Batchinsky, AI Hopmeier, MJ Cancio, LC TI Use of a hyperspectral shock index for the early diagnosis of hemorrhagic shock SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 HyperMed Inc, Weston, MA USA. USA, Inst Surg Res, San Antonio, TX USA. Unconvent Concepts Inc, Mary Esther, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 73 BP U1194 EP U1194 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956406350 ER PT J AU Sharma, SC Tang, XC Singh, BN Reda, DJ Singh, SN Harris, CL Fletcher, RD Atwood, JE Jacobson, AK Lewis, HD Ezekowitz, MD AF Sharma, SC Tang, XC Singh, BN Reda, DJ Singh, SN Harris, CL Fletcher, RD Atwood, JE Jacobson, AK Lewis, HD Ezekowitz, MD TI Impact of restoration and maintenance of sinus rhythm on left atrial dimension and left ventricular ejection fraction in atrial fibrillation (VA Cooperative Study #399) SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 VA Med Ctr, Brown Med Sch, Providence, RI USA. VACSPCC, Hines, IL USA. Univ Calif Los Angeles, Sch Med, VAMC, Los Angeles, CA USA. VACSPCRPCC, Albuquerque, NM USA. VA Med Ctr, Washington, DC USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. VA Med Ctr, Loma Linda, CA USA. VA Med Ctr, Kansas City, KS USA. Drexel Univ, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 2774 BP U648 EP U648 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956404078 ER PT J AU Soller, BR Shear, MA Soyemi, OO Convertino, VA AF Soller, BR Shear, MA Soyemi, OO Convertino, VA TI Preliminary evaluation of noninvasively measured muscle PO2 as an early indicator of hypovolemic shock in human subjects SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 UMass Med Sch, Worcester, MA USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 61 BP U1191 EP U1192 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956406338 ER PT J AU Sondeen, J Dubick, M Prince, D Holcomb, J AF Sondeen, J Dubick, M Prince, D Holcomb, J TI Fresh whole blood is the best hypotensive resuscitative fluid in a severe hemorrhage pig model SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 1616 BP U379 EP U379 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956402198 ER PT J AU Stocker, DJ Taylor, AJ Jezior, MR Langley, RW Vigersky, RA AF Stocker, DJ Taylor, AJ Jezior, MR Langley, RW Vigersky, RA TI Differential effects of rosiglitazone and metformin on inflammation and subclinical atherosclerosis in patients with type 2 diabetes SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 3825 BP U906 EP U906 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956406222 ER PT J AU Taylor, AJ Sullenberger, LE Lee, HY AF Taylor, AJ Sullenberger, LE Lee, HY TI ARBITER 3: Atherosclerosis regression during open-label continuation of extended-release niacin following ARBITER 2 SO CIRCULATION LA English DT Meeting Abstract CT 78th Annual Scientific Session of the American-Heart-Association CY NOV 13-16, 2005 CL Dallas, TX SP Amer Heart Assoc C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 25 PY 2005 VL 112 IS 17 SU S MA 943 BP U235 EP U235 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 979PD UT WOS:000232956401181 ER PT J AU Ramachandran, S Tiwari, A Narayan, J Prater, JT AF Ramachandran, S Tiwari, A Narayan, J Prater, JT TI Epitaxial growth and properties of Zn1-xVxO diluted magnetic semiconductor thin films SO APPLIED PHYSICS LETTERS LA English DT Article ID DOPED ZNO FILMS; ELECTRIC PROPERTIES; FERROMAGNETISM AB Here we report systematic studies on the epitaxial growth and properties of Zn1-xVxO[x=0.001-0.2] thin films deposited onto sapphire c-plane single crystals. The thin films were deposited using pulsed laser deposition technique and were found to be epitaxial in nature. X-ray diffraction and high resolution transmission electron microscopy were employed to study the epitaxial relations of Zn1-xVxO with the sapphire substrate and electron energy loss spectroscopy was used to establish the bonding characteristics and oxidation states of vanadium inside the ZnO host. The main emphasis is on the magnetic properties of this system taking into consideration the phase purity and microstructural characteristics of these films. Our results show that the Zn1-xVxO system, with V in zinc substitutional sites, does not exhibit any signature of ferromagnetism, both at room temperature as well as at lower temperatures down to 10 K. (C) 2005 American Institute of Physics. C1 N Carolina State Univ, Dept Mat Sci & Engn, NSF Ctr Adv Mat & Smart Struct, Raleigh, NC 27695 USA. USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Ramachandran, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, NSF Ctr Adv Mat & Smart Struct, Box 7907, Raleigh, NC 27695 USA. EM sramach@unity.ncsu.edu RI Narayan, Jagdish/D-1874-2009 NR 13 TC 46 Z9 51 U1 0 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 24 PY 2005 VL 87 IS 17 AR 172502 DI 10.1063/1.2112185 PG 3 WC Physics, Applied SC Physics GA 976HK UT WOS:000232723700037 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of digermyl sulfide SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrational frequencies; normal modes; infrared spectra; Raman spectra; digermyl sulfide; digermathiane; thiobisgermane; germyl sulfide ID GERMYL DERIVATIVES; MIXED SILYL; CHALCOGENIDES; SPECTRA AB The normal mode frequencies and corresponding vibrational assignments of digermyl sulfide in C-2v symmetry are examined theoretically using the Gaussian 98 set of quantum chemistry codes. All normal modes were successfully assigned to one of six types of motion (Ge-H stretch, Ge-S stretch, Ge-S-Ge bend, H-Ge-H bend, GeH3 wag, and GeH3 twist) predicted-by a group theoretical analysis. Comparing the vibrational frequencies with IR and Raman spectra available in the literature, scaling factors are derived. Predicted infrared and Raman intensities are reported. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSRD, ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD, ECB,RT,DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 19 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD OCT 24 PY 2005 VL 731 IS 1-3 BP 233 EP 238 DI 10.1016/j.theochem.2005.01.051 PG 6 WC Chemistry, Physical SC Chemistry GA 978BO UT WOS:000232847400031 ER PT J AU Weyrauch, T Vorontsov, MA AF Weyrauch, T Vorontsov, MA TI Atmospheric compensation with a speckle beacon in strong scintillation conditions: directed energy and laser communication applications SO APPLIED OPTICS LA English DT Article ID PHASE-DISTORTION CORRECTION; ADAPTIVE OPTICS; DEFORMABLE MIRRORS; SYSTEM; OPTIMIZATION; PROPAGATION; TELESCOPE; BEAM AB Wavefront control experiments in strong scintillation conditions (scintillation index, similar or equal to 1) over a 2.33 km, near-horizontal, atmospheric propagation path are presented. The adaptive-optics system used comprises a tracking and a fast-beam-steering mirror as well as a 132-actuator, microelectromechanical-system, piston-type deformable mirror with a VLSI controller that implements stochastic parallel gradient descent control optimization of a system performance metric. The experiments demonstrate mitigation of atmospheric distortions with a speckle beacon typical for directed energy and free-space laser communication applications. (c) 2005 Optical Society of America C1 Univ Maryland, Inst Syst Res, Intelligent Opt Lab, College Pk, MD 20742 USA. USA, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Weyrauch, T (reprint author), Univ Maryland, Inst Syst Res, Intelligent Opt Lab, College Pk, MD 20742 USA. EM weyrauch@umd.edu; mvorontsov@arl.army.mil NR 29 TC 44 Z9 48 U1 1 U2 19 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 2005 VL 44 IS 30 BP 6388 EP 6401 DI 10.1364/AO.44.006388 PG 14 WC Optics SC Optics GA 975PR UT WOS:000232674900010 PM 16252651 ER PT J AU Zubko, E Petrov, D Shkuratov, Y Videen, G AF Zubko, E Petrov, D Shkuratov, Y Videen, G TI Discrete dipole approximation simulations of scattering by particles with hierarchical structure SO APPLIED OPTICS LA English DT Article ID GRAINS; LIGHT AB We use the discrete dipole approximation (DDA) method to calculate the intensity and the linear polarization degree of light scattered by agglomerated debris particles with hierarchical structure as functions of size parameter (varying from x = 2 to x = 14) and phase angle. Such structures are important, e.g., for cometary and interplanetary dust particles. Calculations for three combinations of refractive index were made, which correspond to regions of water ice, organic matter, and silicates. We examine the photometric and polarization properties of agglomerated particles with prefractal (Whitten-Sander model) and nonfractal porous structures of particle fragments formed by dipoles. We find that the aggregated particles can produce significant negative polarization at small phase angles. Increasing the packing density of dipoles and/or refractive index makes the negative polarization more prominent. The depth of the negative polarization branch depends on the type of internal structure: the negative polarization branch of particles having nonfractal structure is noticeably shallower in comparison with that of those having a prefractal structure. The negative polarization branch depth strongly depends on the imaginary part of the refractive index and increases with decreasing absorption. Polarization phase curves for agglomerated debris particles become smoother as the number of hierarchical levels increases. (c) 2005 Optical Society of America C1 Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. Univ Helsinki, FIN-00014 Helsinki, Finland. AMSRL, Army Res Lab, Adelphi, MD 20783 USA. RP Zubko, E (reprint author), Kharkov Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM gvideen@arl.army.mil NR 17 TC 17 Z9 17 U1 1 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 2005 VL 44 IS 30 BP 6479 EP 6485 DI 10.1364/AO.44.006479 PG 7 WC Optics SC Optics GA 975PR UT WOS:000232674900020 PM 16252660 ER PT J AU Peoples, GE Gurney, JM Hueman, MT Woll, MW Ryan, GB Storrer, CE Fisher, C Shriver, CD Ioannides, CG Ponniah, S AF Peoples, GE Gurney, JM Hueman, MT Woll, MW Ryan, GB Storrer, CE Fisher, C Shriver, CD Ioannides, CG Ponniah, S TI Clinical trial results of a HER2/neu (E75) vaccine to prevent recurrence in high-risk breast cancer patients SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID COLONY-STIMULATING FACTOR; CYTOTOXIC T-LYMPHOCYTES; PEPTIDE-BASED VACCINES; OVARIAN-CANCER; HER-2/NEU PROTOONCOGENE; RANDOMIZED-TRIAL; RADICAL PROSTATECTOMY; DENDRITIC CELLS; IN-VIVO; ADJUVANT AB Purpose E75 is an immunogenic peptide from the HER2/neu protein that is highly expressed in breast cancer. We are conducting a clinical trial of an E75 + granulocyte-macrophage colony-stimulating factor vaccine to assess safety, immunologic response, and the prevention of clinical recurrences in patients with disease-free, node-positive breast cancer (NPBC). Patients and Methods Fifty-three patients with NPBC were enrolled and HLA typed. HLA-A(2+) patients (n = 24) were vaccinated, and HLA-A2(-) patients (n = 29) are observed prospectively as clinical controls. Local/systemic toxicities, immunologic responses, and time to recurrence are being measured. Results Only minor toxicities have occurred (one grade 3 [4%]). All patients have demonstrated clonal expansion of E75-specific CD8(+)T cells that lysed HER2/neu-expressing tumor cells. An optimal dosage and schedule have been established. Patients have developed delayed-type hypersensitivity reactions to E75 postvaccination compared with controls (33 v 7 mm; P < .01). HLA-A(2+) patients have been found to have larger, more poorly differentiated, and more hormonally insensitive tumors compared to HLA-A2- patients. Despite this, the only two deaths have occurred in the control group. The disease-free survival in the vaccinated group is 85.7% compared to 59.8% in the controls at 22 months' median follow-up with a recurrence rate of 8% compared to 21%, respectively (P < .19). Median time to recurrence in the vaccinated patients was prolonged (11 v 8 months), and recurrence correlated with a weak delayed-type hypersensitivity response. Conclusion This HER2/neu (E75) vaccine is safe and effective in eliciting a peptide-specific immune response in vivo. Induced HEB2/neu immunity seems to reduce the recurrence rate in patients with NPBC. C1 Walter Reed Army Med Ctr, Dept Surg, Clin Breast Care Project, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA. RP Peoples, GE (reprint author), Walter Reed Army Med Ctr, Dept Surg, Clin Breast Care Project, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM george.peoples@na.amedd.army.mil NR 38 TC 132 Z9 132 U1 1 U2 6 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD OCT 20 PY 2005 VL 23 IS 30 BP 7536 EP 7545 DI 10.1200/JCO.2005.03.047 PG 10 WC Oncology SC Oncology GA 979IJ UT WOS:000232935300027 PM 16157940 ER PT J AU Killgore, WDS Yurgelun-Todd, DA AF Killgore, WDS Yurgelun-Todd, DA TI Social anxiety predicts amygdala activation in adolescents viewing fearful faces SO NEUROREPORT LA English DT Article DE adolescents; amygdale; anxiety disorder; functional magnetic resonance imaging; limbic system; Multidimensional Anxiety Scale for Children; neuroinnaging; social anxiety ID EMOTIONAL FACIAL EXPRESSIONS; BRAIN AB The amygdala is critically involved in the processing of anxiety in adults, but little is known about the neurogenesis of trait-anxiety during adolescence. We correlated amygdala activity during visual presentations of fearful and happy faces with scores on the Multidimensional Anxiety Scale for Children in 16 adolescents undergoing functional magnetic resonance imaging. During fear perception, amygdala activity positively correlated with several social dimensions of anxiety, including peer rejection, humiliation, performing in public, and being separated from loved ones, but was not correlated with most measured nonsocial dimensions of anxiety. Annygdala responses during happy face presentations correlated positively only with tension/restlessness. During adolescence, amygdala activity appears to be more strongly related to social/interpersonal than nonsocial dimensions of anxiety. C1 Harvard Univ, Sch Med, McLean Hosp, Cognit Neuroimaging Lab, Belmont, MA USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Div Neurosci, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM killgore@mclean.harvard.edu NR 25 TC 76 Z9 77 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD OCT 17 PY 2005 VL 16 IS 15 BP 1671 EP 1675 DI 10.1097/01.wnr.0000180143.99267.bd PG 5 WC Neurosciences SC Neurosciences & Neurology GA 981FW UT WOS:000233073900012 PM 16189475 ER PT J AU Crenshaw, ME AF Crenshaw, ME TI Generalized electromagnetic momentum and the Fresnel relations SO PHYSICS LETTERS A LA English DT Article ID DIELECTRIC MEDIA; ENERGY-MOMENTUM; FORCES; OPTICS; LIGHT; FIELD AB The Dirac analogy between the dynamics of a single mode of the electromagnetic field and a simple harmonic oscillator is used to derive a generalized electromagnetic momentum from the average canonical momentum of harmonic oscillators. A new derivation of the Fresnel relations, based on conservation laws, is presented. (c) 2005 Elsevier B.V. All rights reserved. C1 USA, AMSRD, AMR, WSST,RDECOM, Redstone Arsenal, AL 35898 USA. RP Crenshaw, ME (reprint author), USA, AMSRD, AMR, WSST,RDECOM, Redstone Arsenal, AL 35898 USA. EM michael.crenshaw@us.army.mil NR 18 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 J9 PHYS LETT A JI Phys. Lett. A PD OCT 17 PY 2005 VL 346 IS 4 BP 249 EP 254 DI 10.1016/j.physleta.2005.08.018 PG 6 WC Physics, Multidisciplinary SC Physics GA 971ZB UT WOS:000232422500001 ER PT J AU Beauman, JG AF Beauman, JG TI Genital herpes: A review SO AMERICAN FAMILY PHYSICIAN LA English DT Review ID SIMPLEX-VIRUS TYPE-2; CONTROLLED-TRIAL; ORAL ACYCLOVIR; RISK-FACTORS; RECURRENT; INFECTION; SUPPRESSION; TRANSMISSION; MANAGEMENT; MEN AB Genital herpes simplex virus infection is a recurrent, lifelong disease with no cure. The strongest predictor for infection is a person's number of lifetime sex partners. The natural history includes first-episode mucocutaneous infection, establishment of latency in the dorsal root ganglion, and subsequent reactivation. Most infections are transmitted via asymptomatic viral shedding. Classic outbreaks consist of a skin prodrome and possible constitutional symptoms such as headache, fever, and inguinal lymphadenopathy. As the infection progresses, papules, vesicles on an erythematous base, and erosions appear over hours to days. These lesions usually crust, re-epithelialize, and heal without scarring. First-episode infections are more extensive: primary lesions last two to six weeks versus approximately one week for lesions in recurrent disease. Atypical manifestations are common. Infected persons experience a median of four recurrences per year after their first episode, but rates vary greatly. Genital herpes simplex virus type 2 recurs six times more frequently than type I. Viral culture is preferred over polymerase chain reaction testing for diagnosis. Serologic testing can be useful in persons with a questionable history. Effective oral antiviral medications are available for initial, episodic, and suppressive therapy but are not a cure. There is some evidence that alternative therapies such as (L)-lysine, zinc, and some herbal preparations may offer some benefit. Counseling patients about the risk of transmission is crucial and helps prevent the spread of disease and neonatal complications. C1 Evans US Army Hosp, Ft Carson, CO 80713 USA. RP Beauman, JG (reprint author), Evans US Army Hosp, Ft Carson, CO 80713 USA. NR 40 TC 25 Z9 32 U1 0 U2 5 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD OCT 15 PY 2005 VL 72 IS 8 BP 1527 EP 1534 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 979IV UT WOS:000232936500007 PM 16273819 ER PT J AU Hueman, MT Dehqanzada, ZA Novak, TE Gurney, JM Woll, MM Ryan, GB Storrer, CE Fisher, C McLeod, DG Ioannides, CG Ponniah, S Peoples, GE AF Hueman, MT Dehqanzada, ZA Novak, TE Gurney, JM Woll, MM Ryan, GB Storrer, CE Fisher, C McLeod, DG Ioannides, CG Ponniah, S Peoples, GE TI Phase I clinical trial of a HER-2/neu peptide (E75) vaccine for the prevention of prostate-specific antigen recurrence in high-risk prostate cancer patients SO CLINICAL CANCER RESEARCH LA English DT Article ID RADICAL PROSTATECTOMY; OVARIAN-CANCER; DISEASE RECURRENCE; SITU HYBRIDIZATION; DENDRITIC CELLS; HUMAN-BREAST; CARCINOMA; PROTEIN; IMMUNIZATION; TRASTUZUMAB AB Purpose:The E75 peptide is an immunogenic peptide from the HER-2/neu protein that is substantially expressed in prostate cancer. We are conducting a clinical trial of an E75/granulocyte macrophage colony-stimulating factor vaccine to prevent post-prostatectomy prostate-specific antigen (PSA) recurrences in high-risk prostate cancer (HRPC) patients. Experimental Design: Prostate cancer patients at high risk for recurrence were prospectively evaluated and identified by the validated Center for Prostate Disease Research (CPDR)/CaP-SURE high-risk equation. From these high-risk equation patients, 27 HER-2/neu-expressing prostate cancer patients were enrolled. HLA-A2(+) patients (n = 17) were vaccinated, whereas HLA-A2(-) patients (n = 10) were followed as clinical controls. Local/systemic toxicities, immunologic responses, and time to recurrence were measured. Results: This vaccine is safe with only minor toxicities observed. Additionally, the vaccine is immunogenic with all patients showing both in vivo and in vitro phenotypic and functional immune responses, although variable. HLA-A2(+) patients were found to have larger tumors, higher postoperative Gleason scores, and more high-risk CPDR scores than HLA-A2(-) patients. Despite these differences, disease-free survival was not different between the vaccinated HLA-A2(+) patients and the HLA-A2(-) controls at a median follow up of 23 months. Three of the four vaccinated patients that recurred had rising PSAs at the initiation of the trial. Ex vivo phenotypic assays were predictive of recurrences and correlated in general with functional assays. Conclusions: The E75 vaccine strategy is safe and effective in eliciting an immune response against the HER-2/neu protein in HRPC patients and may be useful as a preventive strategy against disease recurrence. Vaccination in response to a rising PSA may be too late. C1 Uniformed Serv Univ Hlth Sci, Immunol & Res Ctr, Clin Breast Care Project, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC 20307 USA. Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA. RP Peoples, GE (reprint author), Uniformed Serv Univ Hlth Sci, Immunol & Res Ctr, Clin Breast Care Project, 4301 Jones Bridge Rd,Bldg 139, Bethesda, MD 20814 USA. EM george.peoples@na.amedd.army.mil NR 41 TC 39 Z9 39 U1 1 U2 4 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD OCT 15 PY 2005 VL 11 IS 20 BP 7470 EP 7479 DI 10.1158/1078-0432.CCR-05-0235 PG 10 WC Oncology SC Oncology GA 976NB UT WOS:000232739200034 PM 16243821 ER PT J AU Vaccaro, AR Lehman, RA Hurlbert, J Anderson, PA Harris, M Hedlund, R Harrop, J Dvorak, M Wood, K Fehlings, MG Fisher, C Zeiller, SC Anderson, DG Bono, CM Stock, GH Brown, AK Kuklo, T Oner, FC AF Vaccaro, AR Lehman, RA Hurlbert, J Anderson, PA Harris, M Hedlund, R Harrop, J Dvorak, M Wood, K Fehlings, MG Fisher, C Zeiller, SC Anderson, DG Bono, CM Stock, GH Brown, AK Kuklo, T Oner, FC TI A new classification of thoracolumbar injuries - The importance of injury morphology, the integrity of the posterior ligamentous complex, and neurologic status SO SPINE LA English DT Article DE spine trauma; thoracolumbar fractures; classification; clinical pathways ID FRACTURE-DISLOCATIONS; SPINE FRACTURES AB Study Design. A new proposed classification system for thoracolumbar (TL) spine injuries, including injury severity assessment, designed to assist in clinical management. Objective. To devise a practical, yet comprehensive, classification system for TL injuries that assists in clinical decision-making in terms of the need for operative versus nonoperative care and surgical treatment approach in unstable injury patterns. Summary of Background Data. The most appropriate classification of traumatic TL spine injuries remains controversial. Systems currently in use can be cumbersome and difficult to apply. None of the published classification schemata is constructed to aid with decisions in clinical management. Methods. Clinical spine trauma specialists from a variety of institutions around the world were canvassed with respect to information they deemed pivotal in the communication of TL spine trauma and the clinical decision-making process. Traditional injury patterns were reviewed and reconsidered in light of these essential characteristics. An initial validation process to determine the reliability and validity of an earlier version of this system was also undertaken. Results. A new classification system called the Thoracolumbar Injury Classification and Severity Score (TLICS) was devised based on three injury characteristics: 1) morphology of injury determined by radiographic appearance, 2) integrity of the posterior ligamentous complex, and 3) neurologic status of the patient. A composite injury severity score was calculated from these characteristics stratifying patients into surgical and nonsurgical treatment groups. Finally, a methodology was developed to determine the optimum operative approach for surgical injury patterns. Conclusions. Although there will always be limitations to any cataloging system, the TLICS reflects accepted features cited in the literature important in predicting spinal stability, future deformity, and progressive neurologic compromise. This classification system is intended to be easy to apply and to facilitate clinical decision-making as a practical alternative to cumbersome classification systems already in use. The TLICS may improve communication between spine trauma physicians and the education of residents and fellows. Further studies are underway to determine the reliability and validity of this tool. C1 Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. Univ Calgary, Spine Program, Calgary, AB, Canada. Foothills Hosp & Med Ctr, Dept Clin Neurosci, Calgary, AB, Canada. Univ Wisconsin, Dept Orthopaed Surg & Rehabil, Madison, WI USA. Brigham & Womens Hosp, Boston, MA 02115 USA. Haddinge Univ Hosp, Karolinska Inst, Stockholm, Sweden. Thomas Jefferson Univ, Dept Neurosurg, Philadelphia, PA 19107 USA. Univ British Columbia, Dept Orthopaed, Div Spine, Vancouver, BC V5Z 1M9, Canada. Massachusetts Gen Hosp, Dept Orthopaed Surg, Boston, MA 02114 USA. Univ Toronto, Univ Hlth Network, Dept Neurosurg, Toronto, ON, Canada. Boston Univ, Med Ctr, Dept Orthopaed Surg, Boston, MA USA. Univ Utrecht Hosp, Dept Orthoped, Utrecht, Netherlands. RP Vaccaro, AR (reprint author), Rothman Inst, 925 Chestnut St,5th Floor, Philadelphia, PA 19107 USA. EM alexvaccaro3@aol.com RI Oner, FC/L-7769-2013 OI Oner, FC/0000-0003-0858-8243 NR 21 TC 219 Z9 292 U1 1 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0362-2436 J9 SPINE JI SPINE PD OCT 15 PY 2005 VL 30 IS 20 BP 2325 EP 2333 DI 10.1097/01.brs.0000182986.43345.cb PG 9 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 975NS UT WOS:000232669800014 PM 16227897 ER PT J AU Brennan, JK AF Brennan, JK TI Cavity-bias sampling in reaction ensemble Monte Carlo simulations SO MOLECULAR PHYSICS LA English DT Article ID COMPUTER-SIMULATION; PHASE-EQUILIBRIA; THERMODYNAMIC PROPERTIES; COEXISTENCE PROPERTIES; POROUS MATERIALS; FLUIDS; CONFINEMENT; ADSORPTION; PLASMAS AB A methodology is presented to sample efficiently configurations of reacting mixtures in the reaction ensemble Monte Carlo simulation technique. A cavity-biasing scheme is used, which more effectively samples configurations than conventional random sampling. Akin to other biasing schemes that are implemented into insertion-based Monte Carlo methods such as Gibbs ensemble Monte Carlo, the method presented here searches for space in the reacting mixture whereby the insertion of a product molecule is energetically favoured. This sampling bias is then corrected in the acceptance criteria. The approach allows for the study of reacting mixtures at high density as well as for polyatomic molecular species. For some cases, the method is shown to increase the efficiency of the reaction steps by a factor greater than 20. The approach is shown to be readily generalized to other biasing schemes such as orientational-biasing of polar molecules and configurational-biasing of chain-like molecules. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Brennan, JK (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jbrennan@arl.army.mil NR 36 TC 12 Z9 12 U1 0 U2 8 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0026-8976 J9 MOL PHYS JI Mol. Phys. PD OCT 10 PY 2005 VL 103 IS 19 BP 2647 EP 2654 DI 10.1080/00268970500181004 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 956MD UT WOS:000231303000008 ER PT J AU Blakely, JN Holder, JD Corron, NJ Pethel, SD AF Blakely, JN Holder, JD Corron, NJ Pethel, SD TI Simply folded band chaos in a VHF microstrip oscillator SO PHYSICS LETTERS A LA English DT Article DE low-dimensional chaos; oscillator; delay dynamical system; transmission line; radio-frequency ID TRANSMISSION-LINE OSCILLATOR; GENERALIZED ROSSLER SYSTEM; DYNAMICS; FEEDBACK AB We present experimental observations of a microstrip circuit that produces Rossler-like chaos with center frequency of 175 MHz. A simply folded band chaotic attractor is created through a period doubling route. The circuit provides an experimental realization of a chaotic neutral delay differential equation, a largely unexplored type of nonlinear dynamical system. (c) 2005 Elsevier B.V. All rights reserved. C1 USA, AMSRD, AMR, WS,ST, Redstone Arsenal, AL 35898 USA. RP Blakely, JN (reprint author), USA, AMSRD, AMR, WS,ST, Redstone Arsenal, AL 35898 USA. EM jonathan.blakely@us.army.mil OI Blakely, Jonathan/0000-0002-9772-582X; Corron, Ned/0000-0002-3232-5024 NR 18 TC 9 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 J9 PHYS LETT A JI Phys. Lett. A PD OCT 10 PY 2005 VL 346 IS 1-3 BP 111 EP 114 DI 10.1016/j.physleta.2005.07.071 PG 4 WC Physics, Multidisciplinary SC Physics GA 968NJ UT WOS:000232168900015 ER PT J AU Halverson, KM Panchal, RG Nguyen, TL Gussio, R Little, SF Misakian, M Bavari, S Kasianowicz, JJ AF Halverson, KM Panchal, RG Nguyen, TL Gussio, R Little, SF Misakian, M Bavari, S Kasianowicz, JJ TI Anthrax biosensor, protective antigen ion channel asymmetric blockade SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID SYMMETRICAL TETRAALKYLAMMONIUM IONS; PHOSPHOLIPID-BILAYER MEMBRANES; VOLTAGE-DEPENDENT BLOCK; PLANAR LIPID-BILAYERS; LETHAL FACTOR; TOXIN CHANNELS; MONOCLONAL-ANTIBODIES; CRYSTAL-STRUCTURE; MAMMALIAN-CELLS; FACTOR-BINDING AB The significant threat posed by biological agents ( e. g. anthrax, tetanus, botulinum, and diphtheria toxins) (Inglesby, T. V., O'Toole, T., Henderson, D. A., Bartlett, J. G., Ascher, M. S., Eitzen, E., Friedlander, A. M., Gerberding, J., Hauer, J., Hughes, J., McDade, J., Osterholm, M. T., Parker, G., Perl, T. M., Russell, P. K., and Tonat, K. ( 2002) J. Am. Med. Assoc. 287, 2236 - 2252) requires innovative technologies and approaches to understand the mechanisms of toxin action and to develop better therapies. Anthrax toxins are formed from three proteins secreted by fully virulent Bacillus anthracis, protective antigen (PA, 83 kDa), lethal factor (LF, 90 kDa), and edema factor (EF, 89 kDa). Here we present electrophysiological measurements demonstrating that full-length LF and EF convert the current-voltage relationship of the heptameric PA(63) ion channel from slightly nonlinear to highly rectifying and diode-like at pH 6.6. This effect provides a novel method for characterizing functional toxin interactions. The method confirms that a previously well characterized PA(63) monoclonal antibody, which neutralizes anthrax lethal toxin in animals in vivo and in vitro, prevents the binding of LF to the PA(63) pore. The technique can also detect the presence of anthrax lethal toxin complex from plasma of infected animals. The latter two results suggest the potential application of PA(63) nanopore-based biosensors in anthrax therapeutics and diagnostics. C1 Natl Inst Stand & Technol, Adv Chem Sci Lab, Gaithersburg, MD 20899 USA. Natl Inst Stand & Technol, Elect & Elect Engn Lab, Semicond Engn Div, Gaithersburg, MD 20899 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. NCI, Dev Therapeut Program, Target Struct Based Drug Discovery Grp, Sci Applicat Int Corp, Frederick, MD 21702 USA. RP Kasianowicz, JJ (reprint author), Natl Inst Stand & Technol, Adv Chem Sci Lab, Bldg 225,Rm B326, Gaithersburg, MD 20899 USA. EM john.kasianowicz@nist.gov NR 35 TC 56 Z9 56 U1 0 U2 14 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD OCT 7 PY 2005 VL 280 IS 40 BP 34056 EP 34062 DI 10.1074/jbc.M507928200 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 969JF UT WOS:000232229700045 PM 16087661 ER PT J AU Jensen, JO AF Jensen, JO TI Vibrational frequencies and structural determination of cyanogen azide SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE vibrations; normal mode frequencies; infrared spectra; Raman spectra; cyanogen azide; carbon pernitride; cyano azide ID MICROWAVE-SPECTRUM; INFRARED-SPECTRUM; CARBON NITRIDE; NCN3; PHOTODISSOCIATION; SPECTROSCOPY; PHOTOLYSIS; CN AB The vibrational frequencies and corresponding normal mode assignments of cyanogen azide are examined theoretically using the Gaussian03 set of quantum chemistry codes. All normal modes were successfully assigned to one of seven types of motion predicted by a group theoretical analysis (N&3bond; N stretch, N=N stretch, N-C stretch, C&3bond; N stretch, N&3bond; N=N bend, N=N-C bend, and N-C&3bond; N bend). Theoretical infrared and Raman intensities are reported. The molecular orbitals and bonding of cyanogen azide are examined. Published by Elsevier B.V. C1 USA, Edgewood Chem & Biol Ctr, AMSRD ECB RT DP, Aberdeen Proving Ground, MD 21010 USA. RP Jensen, JO (reprint author), USA, Edgewood Chem & Biol Ctr, AMSRD ECB RT DP, Aberdeen Proving Ground, MD 21010 USA. EM jim.jensen@us.army.mil NR 34 TC 4 Z9 4 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD OCT 7 PY 2005 VL 730 IS 1-3 BP 235 EP 239 DI 10.1016/j.theochem.2005.01.050 PG 5 WC Chemistry, Physical SC Chemistry GA 970PA UT WOS:000232320900029 ER PT J AU Zhang, Q Guan, J Sacci, J Ager, A Ellis, W Milhous, W Kyle, D Lin, AJ AF Zhang, Q Guan, J Sacci, J Ager, A Ellis, W Milhous, W Kyle, D Lin, AJ TI Unambiguous synthesis and prophylactic antimalarial activities of imidazolidinedione derivatives SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID TROPHOZOITE-INDUCED INFECTIONS; PLASMODIUM-FALCIPARUM MALARIA; TAFENOQUINE; DRUGS; MEFLOQUINE; CYNOMOLGI; EFFICACY; MONKEYS; ESTERS; UREAS AB WR182393, a guanidinoimidazolidinedione derivatives with potent causal prophylactic antimalarial activity by intramuscular injection, was previouly prepared by treatment of chloroproguanil and diethyl oxalate, yielding a mixture of two closely related isomers. Poor solubility of the mixture made the separation and purification impossible. To overcome the separation problem, new and facile unamgibuous syntheses of the two active components were reported. The new synthetic methods facilitate the synthesis of not only the active components, but also their derivatives. To search for compounds with good oral efficacy, a series of carbamate derivatives of the active components were prepared by the new procedure, many of which showed profound causal prophylactic antimalarial activity against Plasmodium yoelii in mouse by oral administration. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Univ Miami, Miami, FL 33177 USA. RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM ai.lin@na.amedd.army.mil NR 33 TC 15 Z9 15 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD OCT 6 PY 2005 VL 48 IS 20 BP 6472 EP 6481 DI 10.1021/jm0504252 PG 10 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 971TC UT WOS:000232406600031 PM 16190773 ER PT J AU Harvey, SP Kolakowski, JE Cheng, TC Rastogi, VK Reiff, LP DeFrank, JJ Raushel, FM Hill, C AF Harvey, SP Kolakowski, JE Cheng, TC Rastogi, VK Reiff, LP DeFrank, JJ Raushel, FM Hill, C TI Stereospecificity in the enzymatic hydrolysis of cyclosarin (GF) SO ENZYME AND MICROBIAL TECHNOLOGY LA English DT Article DE stereochemistry; cyclosarin; GF; enzyme; isomer; stereospecificity; acetylcholinesterase ID PARATHION HYDROLASE GENE; ORGANOPHOSPHORUS NERVE AGENTS; SITE-DIRECTED MUTAGENESIS; CHEMICAL WARFARE AGENTS; PSEUDOMONAS-DIMINUTA; NUCLEOTIDE-SEQUENCE; PHOSPHOTRIESTERASE; EXPRESSION; ACETYLCHOLINESTERASE; CLONING AB Enzymatic catalysis is one means of accelerating the rate of hydrolysis of G-type organophosphorus nerve agents. Here, the stereospecificity of the catalysis of cyclosarin (GF, O-cyclohexyl methylphosphonofluoridate) hydrolysis by several enzymes was investigated. Stercospecificity was not evident at 3 mM GF but was evident at 0.5 mM GF. The differential effect was apparently due to fluoride-catalyzed racemization of the substrate. Alteromonas sp. JD6.5 organophosphorus acid anhydrolase (OPAA), Alteromonas haloplanktis OPAA and the wild-type phosphotriesterase (PTE) enzymes were all found to catalyze preferentially the hydrolysis of the (+)GF isomer, as determined by GC analysis of the remaining unreacted (-)GF isomer. Acetylcholinesterase inhibition experiments showed the purified (-)GF isomer to be approximately twice as toxic as the racemic mixture. One PTE mutant, H254G/H259W/L303T, was found to reverse the native PTE stereospecificity and preferentially catalyze the hydrolysis of the (-)GF isomer, as shown by its complementation of Alteromonas sp. JD6.5 OPAA and by GC analysis of the remaining (+)GF isomer. This procedure also permitted the individual preparation of either of the two GF isomers by enzymatic degradation followed by extraction of the remaining isomer. (c) 2005 Elsevier Inc. All rights reserved. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA. RP Harvey, SP (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM steve.harvey@us.army.mil RI Raushel, Frank/B-7125-2015 OI Raushel, Frank/0000-0002-5918-3089 NR 32 TC 20 Z9 20 U1 3 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0141-0229 J9 ENZYME MICROB TECH JI Enzyme Microb. Technol. PD OCT 3 PY 2005 VL 37 IS 5 BP 547 EP 555 DI 10.1016/j.enzmictec.2005.04.004 PG 9 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 959ZH UT WOS:000231557800012 ER PT J AU Zhang, H Ramesh, KT Chin, ESC AF Zhang, H Ramesh, KT Chin, ESC TI Effects of interfacial debonding on the rate-dependent response of metal matrix composites SO ACTA MATERIALIA LA English DT Article DE finite element analysis; metal matrix composites; interfacial debonding; high strain rates; plastic deformation ID WHISKER-REINFORCED METAL; HIGH-STRAIN-RATE; RESIDUAL-STRESSES; BIMATERIAL INTERFACES; PARTICLE DISTRIBUTION; MECHANICAL-PROPERTIES; FRACTURE-RESISTANCE; PLASTIC-DEFORMATION; CERAMIC COMPOSITES; FAILURE MECHANISMS AB The effect of interface damage on the rate-dependent constitutive behavior of particle reinforced metal matrix composites (MMCs) is investigated. The constitutive behavior of the matrix-reinforcement interface is characterized by a cohesive zone model, and the effects of interface strength and separation energy on MMC constitutive behavior are examined over a wide strain rate range (10(-3)-10(4) s(-1)). The consequences of interface failure on the overall constitutive behavior of the composite are discussed in conjunction with the influences of reinforcement volume fraction, strain rate, particle shape and aspect ratio. The computational results are compared with experimental data obtained on the quasistatic and high-rate response of MMCs subjected to compression and tension, with good correlation. (c) 2005 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, H (reprint author), Johns Hopkins Univ, Dept Mech Engn, 223 Latrobe Hall,3400 N Charles St, Baltimore, MD 21218 USA. EM hzhang@poseidon.me.jhu.edu NR 52 TC 30 Z9 32 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD OCT PY 2005 VL 53 IS 17 BP 4687 EP 4700 DI 10.1016/j.actamat.2005.07.004 PG 14 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 968QP UT WOS:000232177500019 ER PT J AU Carrera, M Kesavan, J Zandomeni, R Sagripanti, JL AF Carrera, M Kesavan, J Zandomeni, R Sagripanti, JL TI Method to determine the number of bacterial spores within aerosol particles SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID BIOAEROSOL SAMPLERS; PERFORMANCE; COLLECTION AB We describe methodology to reveal the number of microbial spores within aerosol particles. The procedure involves visualization under differential-interference-contrast microscopy enhanced by high-resolution photography and further analysis by computer-assisted imaging. The method was used to analyze spore of Bacillus globigii in aerosols generated by a small (pressured metered-dose inhaler type) generator. Particles consisting in 1 or 2 spores accounted for 85% of all generated particles. This percentage rose to 91% when the same aerosol was collected on an Andersen cascade impactor that collected particles larger than 0.65 mu m and was even higher (96%) when particles larger than 3.3 mu m were also eliminated. These results demonstrate that the imaging analysis of aerosol particles collected on glass slides is sensitive to even relatively small changes in aerosol particle composition. The accuracy of the enhanced microscopic method described herein (differences between visual and computer analysis were approximately 3% of the total particle counts) seems adequate to determine the spore composition of aerosols of interest in biodefense. C1 USA, RDECOM, AMSRD,Res & Technol Directorate, ECB,RT,Res & Technol Directorate,Edgewood Chem Bi, Aberdeen Proving Ground, MD 21010 USA. Geocenters Inc, Gunpowder Branch, Aberdeen Proving Ground, MD USA. RP Sagripanti, JL (reprint author), USA, RDECOM, AMSRD,Res & Technol Directorate, ECB,RT,Res & Technol Directorate,Edgewood Chem Bi, Bldg 3150, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil NR 14 TC 16 Z9 17 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD OCT PY 2005 VL 39 IS 10 BP 960 EP 965 DI 10.1080/02786820500352098 PG 6 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 992AO UT WOS:000233856400005 ER PT J AU Rios, M Fernandez, J Jaramillo, P Paredes, V Sanchez, JL Laguna-Torres, VA Carr, JK Ramirez, E AF Rios, M Fernandez, J Jaramillo, P Paredes, V Sanchez, JL Laguna-Torres, VA Carr, JK Ramirez, E TI Molecular epidemiology of HIV type 1 in Chile: Differential geographic and transmission route distribution of B and F subtypes SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID CIRCULATING RECOMBINANT FORM; GENETIC SUBTYPES; IDENTIFICATION; NEUTRALIZATION; INFECTIONS; ARGENTINA; VARIANTS; AMERICA; BRAZIL; DNA AB We examined the genetic makeup of 221 HIV-1 strains from Chilean persons living with HIV/AIDS by HMA and DNA sequencing of the env gene: 143 cases were infected by sexual contact with an already-infected partner, 76 were infected by mother-to-child transmission, and 2 were transfusion related. We found env HIV-1 subtype B in 202 cases (91.4%) and subtype F in 19 cases (8.6%). Subtype B strains were found throughout the country whereas subtype F viruses were predominantly found in cases from the metropolitan/central to the northern regions of Chile (p < 0.01). Chilean F subtypes clustered in two different groups: viruses from the central region clustered with F subtypes from Argentina, Uruguay, and Brazil, and viruses from the northern region, which independently segregated from other South American and European F strains. All of the 59 men having sex with men (MSM) were infected with B subtype strains whereas 7 (9.2%) and 12 (15.8%), respectively, of heterosexually infected females and children were infected with F subtype strains (p < 0.01). It appears that F subtype strains have been introduced into Chile by separate heterosexual transmission events from other nearby countries in the Southern Cone whereas B subtype strains have continued to persist predominantly among MSM. C1 Inst Salud Publ Chile, Subdept Virol, Natl Reference Ctr Retroviruses, Santiago, Chile. Inst Salud Publ Chile, Mol Biol Sect, Santiago, Chile. USN, Med Res Ctr Detachment, Lima, Peru. Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. Henry M Jackson Fdn, Rockville, MD USA. Univ Chile, Fac Med, Program Virol, Inst Ciencias Biomed, Santiago 7, Chile. RP Ramirez, E (reprint author), Inst Salud Publ Chile, Subdept Virol, Natl Reference Ctr Retroviruses, Ave Marathon 1000, Santiago, Chile. EM eramirez@ispch.cl NR 28 TC 13 Z9 14 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2005 VL 21 IS 10 BP 835 EP 840 DI 10.1089/aid.2005.21.835 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 979SN UT WOS:000232965200001 PM 16225409 ER PT J AU Newton, MA AF Newton, MA TI Military justice in America: The US Court of Appeals for the armed forces, 1775-1980. SO AMERICAN HISTORICAL REVIEW LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Newton, MA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 USA SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD OCT PY 2005 VL 110 IS 4 BP 1157 EP 1158 DI 10.1086/ahr.110.4.1157 PG 2 WC History SC History GA 979TX UT WOS:000232968800050 ER PT J AU Kalantar-Zadeh, K Abbott, KC Salahudeen, AK AF Kalantar-Zadeh, K Abbott, KC Salahudeen, AK TI The paradox of the "body mass index paradox" in dialysis patients: associations of adiposity with inflammation - Reply SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Letter ID CARDIOVASCULAR RISK-FACTORS; REVERSE EPIDEMIOLOGY; SURVIVAL; OBESITY C1 Harbor UCLA Med Ctr, Los Angeles Biomed Inst, Div Nephrol & Hypertens, Torrance, CA 90502 USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA. RP Kalantar-Zadeh, K (reprint author), Harbor UCLA Med Ctr, Los Angeles Biomed Inst, Div Nephrol & Hypertens, Harbor Mailbox 406,1000 W Carson St, Torrance, CA 90502 USA. EM kamkal@ucla.edu NR 10 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD OCT PY 2005 VL 82 IS 4 BP 910 EP 911 PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 973CN UT WOS:000232500600029 ER PT J AU Deng, A Petrali, J Jaffe, D Sina, B Gaspari, A AF Deng, A Petrali, J Jaffe, D Sina, B Gaspari, A TI Benign cutaneous pseudoglandular schwannoma - A case report SO AMERICAN JOURNAL OF DERMATOPATHOLOGY LA English DT Article DE electron microscopy; immunohistochemistry; pseudoglandular; schwannoma; Schwann cells ID GLANDULAR SCHWANNOMA; TUMORS AB Schwannoma is a common peripheral neural neoplasm that could present as a primary skin lesion. In addition to typical schwannoma with classic Antoni A and Antoni B areas, many variant types have been described, such as plexiform, cellular, epithelioid, and ancient schwannomas. Glandular schwannoma is a rare variant characterized by the presence of glands in an otherwise typical schwannoma. There are also a few reported cases in the literature of pseudoglandular schwannoma from central nervous system, eye, submandible, and shoulder, in which the gland-like structures were lined by Schwann cells. We report here a patient with a benign cutaneous schwannoma composed of predominantly gland-like spaces that contained mucinous material and were lined by Schwann cells confirmed by immunohistochemistry and ultrastructural studies. The tumor was well circumscribed and showed minimal cytologic atypia, indicating benignity. We report this unusual case of benign cutaneous pseudoglandular schwannoma to further awareness of the morphologic diversity of schwannoma. C1 Univ Maryland, Sch Med, Dept Dermatol, Baltimore, MD 21201 USA. USA, Med Res Inst, Aberdeen Proving Ground, MD USA. RP Deng, A (reprint author), Univ Maryland, Sch Med, Dept Dermatol, 405 W Redwood St,6th FL, Baltimore, MD 21201 USA. EM adeng@som.umaryland.edu NR 10 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0193-1091 J9 AM J DERMATOPATH JI Am. J. Dermatopathol. PD OCT PY 2005 VL 27 IS 5 BP 432 EP 435 DI 10.1097/01.dad.0000175534.73110.4e PG 4 WC Dermatology SC Dermatology GA 969PE UT WOS:000232245700011 PM 16148415 ER PT J AU Gerhardt, RT Nelson, BK Keenan, S Kernan, L MacKersie, A Lane, MS AF Gerhardt, RT Nelson, BK Keenan, S Kernan, L MacKersie, A Lane, MS TI Derivation of a clinical guideline for the assessment of nonspecific abdominal pain: the Guideline for Abdominal Pain in the ED Setting (GAPEDS) Phase 1 Study SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 12-13, 2003 CL Boston, MA SP Amer Coll Emergency Physicians ID UNENHANCED CT; APPENDICITIS; STANDARDS; DIAGNOSIS; RULES AB Objective: The purpose of this study was to identify a clinical guideline for the evaluation of nonspecific abdominal pain (NSAP) using history, physical examination, laboratory analysis, acute abdominal series (AAS) radiographs, and nonenhanced helical computed tomography (NHCT) clinical predictor variables (CPVs). Setting: The setting of this study was at an urban emergency department (ED) with 70 000 yearly visits. Methods: This is an institutional review board-approved, prospective, observational study. The primary outcome variable was urgent intervention (UI), defined as a diagnosis requiring surgical or medical treatment to prevent death or major morbidity. Subjects underwent prompted history, physical, laboratory studies, AAS, and NHCT and were followed up to 6 months for ultimate diagnosis and outcome. CPVs were subjected to classification and regression tree analysis. Results: One hundred sixty-five subjects were analyzed. Thirteen percent of subjects required UI within 24 hours of presentation; an additional 34% underwent elective interventions that mitigated morbidity or mortality. Four guideline models were generated. Model I consisted of history and physical, with a sensitivity of 25%, a specificity of 92%, a positive likelihood ratio of 3.17, and a negative likelihood ratio of 0.81. Model 2 consisted of model I with laboratory, with a sensitivity of 39%, a specificity of 88%, a positive likelihood ratio of 3.25, and a negative likelihood ratio of 0.69. Model 3 consisted of model 2 with AAS, with a sensitivity of 56%, a specificity of 81%, a positive likelihood ratio of 2.94, and a negative likelihood ratio of 0.54. Model 4 comprised all inputs, including NHCT, with a sensitivity of 92%, a specificity of 90%, a positive likelihood ratio of 9.2, and a negative likelihood ratio of 0.089. NHCT was the single most accurate CPV for UI. Conclusions: No clinical guideline was identified exclusive of NHCT that possessed adequate sensitivity for exclusion of UI. NHCT is a rational choice for decision support in the evaluation of NSAP and is likely the single most useful diagnostic adjunct available to augment the clinical evaluation. (c) 2005 Elsevier Inc. All rights reserved. C1 San Antonio Uniformed Serv Hlth Educ Consortium, Dept Emergency Med, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. San Antonio Uniformed Serv Hlth Educ Consortium, Dept Radiol, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Texas Tech Univ, Hlth Sci Ctr, Dept Emergency Med, El Paso, TX 79905 USA. RP Gerhardt, RT (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, Dept Emergency Med, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM robert.gerhardt@us.army.mil NR 21 TC 23 Z9 23 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD OCT PY 2005 VL 23 IS 6 BP 709 EP 717 DI 10.1016/j.ajem.2005.01.010 PG 9 WC Emergency Medicine SC Emergency Medicine GA 974XO UT WOS:000232624900001 PM 16182976 ER PT J AU Song, A AF Song, A TI SOAP note: Why I want to complete a pharmacy practice residency SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Editorial Material C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Song, A (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM adreahna@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD OCT 1 PY 2005 VL 62 IS 19 BP 2041 EP 2042 DI 10.2146/ajhp050049 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 970XY UT WOS:000232346900024 PM 16174843 ER PT J AU Lentine, KL Schnitzler, MA Abbott, KC Li, LM Burroughs, TE Irish, W Brennan, DC AF Lentine, KL Schnitzler, MA Abbott, KC Li, LM Burroughs, TE Irish, W Brennan, DC TI De novo congestive heart failure after kidney transplantation: A common condition with poor prognostic implications SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Article DE heart failure; kidney transplantation; Medicare; registry; risk factors ID STAGE RENAL-DISEASE; UNITED-STATES; CARDIOVASCULAR-DISEASE; RISK; RECIPIENTS; SURVIVAL; ANEMIA; IMPACT; WOMEN; HOSPITALIZATIONS AB Background: We aim to describe the risk, predictors, and outcomes associated with de novo congestive heart failure (CHF) after kidney transplantation. Methods: We used registry data from the US Renal Data System to retrospectively investigate de novo CHF in adult Medicare-insured transplant recipients and wait-listed candidates in 1995 to 2001. Heart failure was ascertained from inpatient and outpatient billing records, and participants were followed up until loss of Medicare or December 31, 2001. We used extended Cox hazards analysis to identify independent correlates of posttransplantation de novo CHF (adjusted hazard ratio [AHR], 95% confidence interval [Cl]) and examine de novo CHF as a predictor of death and graft loss after transplantation. Results: In 27,011 transplant recipients, cumulative incidences of de novo CHF were 10.2% (95% CI, 9.8 to 10.6) and 18.3% (95% CI, 17.8 to 18.9) at 12 and 36 months and decreased to less than the demographic-adjusted incidence on the waiting list beyond the early posttransplantation period. Risk factors for de novo CHF included older recipient age, female sex, unemployed status at transplantation, pretransplantation comorbidities (anemia, diabetes mellitus, myocardial infarction, angina, cardiac arrhythmia, and peripheral vascular disease), transplant from older donors, donor cardiovascular death, and delayed graft function. We identified pretransplantation obesity, smoking, and posttransplantation complications, including hypertension, anemia, new-onset diabetes, myocardial infarction, and graft failure, as potentially modifiable correlates of de novo CHF. In separate analyses, de novo CHF predicted death (AHR, 2.6; 95% CI, 2.4 to 2.9) and death-censored graft failure (AHR, 2.7; 95% Cl, 2.4 to 3.0). Conclusion: Although associations may not reflect causality, identification of potentially mutable de novo CHF risk factors suggests targets for improving outcomes that should be evaluated prospectively. C1 St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63104 USA. St Louis Univ, Div Nephrol, Sch Med, St Louis, MO 63104 USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. RTI Hlth Solut, Res Triangle Pk, NC USA. Washington Univ, Sch Med, Div Nephrol, St Louis, MO USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Sch Med, Salus Ctr 2nd Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentine.krista@stanfordalumni.org OI Abbott, Kevin/0000-0003-2111-7112 FU NIDDK NIH HHS [K24DK002886-02, K25-DK-02916-01] NR 43 TC 46 Z9 47 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD OCT PY 2005 VL 46 IS 4 BP 720 EP 733 DI 10.1053/j.ajkd.2005.06.019 PG 14 WC Urology & Nephrology SC Urology & Nephrology GA 993DQ UT WOS:000233933300019 PM 16183428 ER PT J AU Sjogren, MH AF Sjogren, MH TI Prevention of hepatitis B in nonresponders to initial hepatitis B virus vaccination SO AMERICAN JOURNAL OF MEDICINE LA English DT Article DE antibody; hepatitis B; immunity; response; vaccine ID YUPIK ESKIMO POPULATION; HEALTH-CARE WORKERS; COMPARATIVE TRIAL; IMMUNOGENICITY; PROTECTION; EFFICACY; IMMUNITY; DISEASE; MEN AB Although vaccination against hepatitis B virus (HBV) is highly successful, 5% to 10% of individuals do not experience a response with an adequate antibody level to hepatitis B surface antigen (anti-HBs). Contributing causes for nonresponse to the vaccine are genetic predisposition, immunosuppression, and certain chronic illnesses. The distinction between true nonresponse (after adequate immunization) and waning anti-HBs levels is important. The latter is not uncommon in populations in areas of the world with low endemicity for HBV infection. Data from subjects with waning anti-HBs levels show that immunologic memory may still protect these individuals against acute HBV infection or may prevent chronic infection with HBV for <= 10 years after immunization. Recent reports from Asia and Alaska describe cases of chronic HBV infection 15 years after immunization in subjects who have very low levels of anti-HBs. Thus, nonresponders or those with waning immunity who may be at risk of HBV infection in subsequent years may require a booster dose. Clinical algorithms to reimmunize nonresponders have been described and are discussed in this article. Experimental hepatitis B vaccines have shown some promise in nonresponders but are not commercially available in the United States. (c) 2005 Elsevier Inc. All rights reserved. C1 Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. RP Sjogren, MH (reprint author), Walter Reed Army Med Ctr, Dept Clin Invest, 6900 Georgia Ave NW,Bldg 6,Room 4018, Washington, DC 20307 USA. NR 25 TC 38 Z9 40 U1 0 U2 2 PU EXCERPTA MEDICA INC PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA SN 0002-9343 J9 AM J MED JI Am. J. Med. PD OCT PY 2005 VL 118 SU 10A BP 34 EP 39 DI 10.1016/j.amjmed.2005.07.012 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 973PM UT WOS:000232535100006 ER PT J AU Radvany, MG Allan, PF Frey, WC Banks, KP Malave, D AF Radvany, MG Allan, PF Frey, WC Banks, KP Malave, D TI Pulmonary radiofrequency ablation complicated by subcutaneous emphysema and pneumomediastinum treated with fibrin sealant injection SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID LUNG; GLUE C1 Brooke Army Med Ctr, MCHE DR, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Brooke Army Med Ctr, Dept Pulm Med, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Cardiothorac Surg, Ft Sam Houston, TX 78234 USA. RP Radvany, MG (reprint author), Brooke Army Med Ctr, MCHE DR, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 11 TC 7 Z9 10 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2005 VL 185 IS 4 BP 894 EP 898 DI 10.2214/AJR.04.0235 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 968EZ UT WOS:000232146000014 PM 16177407 ER PT J AU Ahn, PJ Bertagnolli, R Fraser, SL Freeman, JH AF Ahn, PJ Bertagnolli, R Fraser, SL Freeman, JH TI Distended thoracic duct and diffuse lymphangiectasia caused by Bancroftian filariasis SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID MAGNETIC-RESONANCE C1 Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. RP Ahn, PJ (reprint author), Tripler Army Med Ctr, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Peter.Ahn@andrews.af.mil NR 6 TC 4 Z9 4 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2005 VL 185 IS 4 BP 1011 EP 1014 DI 10.2214/AJR.04.1041 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 968EZ UT WOS:000232146000032 PM 16177425 ER PT J AU Cohen, SP Griffith, S Larkin, TM Villena, F Larkin, R AF Cohen, SP Griffith, S Larkin, TM Villena, F Larkin, R TI Presentation, diagnoses, mechanisms of injury, and treatment of soldiers injured in Operation Iraqi Freedom: An epidemiological study conducted at two military pain management centers SO ANESTHESIA AND ANALGESIA LA English DT Article ID CASUALTIES; WAR AB In recent military conflicts the major source of soldier attrition has not been battle injuries but more mundane causes similar to those encountered in civilian life. In an effort to determine the pain conditions affecting soldiers during wartime, we conducted an observational study among 162 soldiers medically evacuated from Operation Iraqi Freedom who were referred to 2 large pain treatment centers located outside the theaters of combat. Fifty-three percent of soldiers presented with either radicular (n = 49) or axial (n = 37) low back pain, with lumbar herniated disk being the most frequently diagnosed condition (24%). The two most implicated etiologies were exacerbation of a previous pain condition treated with surgery (15%) and motor vehicle accidents (12%). Only 17% of patients were injured during battle. Seventy-two percent of soldiers received at least one nerve block/injection, the most common of which was lumbar epidural steroid administration (22%). Nonsteroidal antiinflammatory drugs were prescribed to 56% of patients, opioids to 49%, and some form of alternative therapy to 17%. Among the 49 patients in whom data were available, only 2% returned to combat duty in Iraq. With the exception of battle-related injuries, the pain conditions suffered during modern warfare seem to be similar to those encountered in civilian pain clinics. To improve the return-to-duty rate, better preventive measures and more aggressive treatment conducted in forward-deployed medical units are recommended. C1 Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA. Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Anesthesiol, Washington, DC 20307 USA. Landstuhl Reg Army Med Ctr, Pain Management Ctr, Landstuhl, Germany. RP Cohen, SP (reprint author), Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 15 TC 45 Z9 47 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD OCT PY 2005 VL 101 IS 4 BP 1098 EP 1103 DI 10.1213/01.ane.0000169332.45209.cf PG 6 WC Anesthesiology SC Anesthesiology GA 967TZ UT WOS:000232115400032 PM 16192528 ER PT J AU Lotufo, GR Farrar, JD AF Lotufo, GR Farrar, JD TI Comparative and mixture sediment toxicity of trinitrotoluene and its major transformation products to a freshwater midge SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID EARTHWORM EISENIA-ANDREI; TNT METABOLITES; 2,4,6-TRINITROTOLUENE; SOIL; BINDING; MUTAGENICITY; REDUCTION; FATE AB The explosive trinitrotoluene (TNT) is a prevalent contaminant in many military installations worldwide. Limited knowledge of the comparative toxicity of sediment-associated TNT and related compounds contributes to uncertainty when assessing ecological risks in contaminated sites. Trinitrotoluene undergoes transformation when associated with soils and sediments and typically occurs as a mixture dominated by its reduction products. The objective of this study was to comparatively evaluate the single-compound toxicity of TNT and its major transformation products to the freshwater midge Chironomus tentans in 10-day exposures to sediment spiked with TNT, 2-aminodinitrotoluene (2-ADNT), 2,4-diaminonitrotoluene (2,4-DANT), or trinitrobenzene (TNB). In addition, the nature of the toxicological interactions of the latter compounds in a mixture was evaluated. Upon spiking to sediment, TNT and TNB rapidly degraded to reduced products, and disappearance of extractable compounds suggested irreversible binding to sediment particles. The high degree of transformation and reactivity occurring during 10 days at spiking concentrations as high as 4000 mu mol/kg dry weight suggests that TNT and related compounds are unlikely to be encountered in fine-grained sediments at contaminated sites. Similar to previous investigations, the high reactivity of the spiked compound hampered determination of accurate toxic concentrations of TNT and related compounds, and of the nature of toxicological interaction of compounds in a mixture in this study. Sediment concentrations associated with decreased survival were similar for all four compounds, with the 10-d median lethal concentrations (LC50s) determined using initial concentrations ranging from 175 (2-ADNT) to 605 (2,4-DANT) mu mol/kg dry weight. Sublethal decrease in growth was not observed for any compound. Results from the mixture experiment suggest additive interaction among TNT and related compounds in sediment exposures. C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lotufo, GR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd,EP-R, Vicksburg, MS 39180 USA. EM guilherme.lotufo@erdc.usace.army.mil NR 32 TC 7 Z9 7 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD OCT PY 2005 VL 49 IS 3 BP 333 EP 342 DI 10.1007/s00244-004-0213-y PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 966WJ UT WOS:000232053200007 PM 16170451 ER PT J AU Ender, MG AF Ender, MG TI Military brats - Film representations of children from military families SO ARMED FORCES & SOCIETY LA English DT Article; Proceedings Paper CT Annual Meeting on Military Child Education Coalition CY JUL 24, 2003 CL Groton, CT DE film; military children; teenagers; military family; self-concept AB Thousands of films cover war and the military, but few highlight military family life. This study reports a systematic content analysis of forty-six films between 1935 and 2002 that spotlight children, adolescents, teenagers, and adults from military-service-related families. The results show a diverse range of portrayals across military branches, wars, genders, races, ages, military ranks, roles, and familial relationships. Furthermore, cinematic demands of military family life are portrayed inconsistently with real life experiences reinforcing a modest civil-military gap. Finally, six patterned characteristics emerge from the content analysis including intergenerational military occupational linkages, social deviance, precociousness, social mobility, youth romance, and parent-child conflicts. The present study partially confirms studies of civilian youth in film suggesting a diverse cinematic experience at the teenage stage of the life course. The results highlight a struggle in the negotiation between self-conceptions and self-images of children from military families where a reinforced stereotype of "military brat" is constructed in American cinema. C1 US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Ender, MG (reprint author), US Mil Acad, Dept Behav Sci & Leadership, Thayer Hall 282E, West Point, NY 10996 USA. EM lm2643@usma.edu NR 53 TC 2 Z9 2 U1 0 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2005 VL 32 IS 1 BP 24 EP 43 DI 10.1177/0095327X05277887 PG 20 WC Political Science; Sociology SC Government & Law; Sociology GA 036WI UT WOS:000237107100002 ER EF