FN Thomson Reuters Web of Science™ VR 1.0 PT B AU Peters, J Howington, S Eslinger, O Fairley, J Ballard, J Goodson, R Carpenter, V AF Peters, John Howington, Stacy Eslinger, Owen Fairley, Josh Ballard, Jerry Goodson, Ricky Carpenter, Virginia TI Signature Evaluation for Thermal Infrared Countermine and IED Detection Systems SO PROCEEDINGS OF THE HPCMP USERS GROUP CONFERENCE 2008 LA English DT Proceedings Paper CT Conference on High Performance Computer Modernization Program CY JUL 14-17, 2008 CL Seattle, WA AB The countermine computational testbed is a coupled system of parallelized computer codes and associated software tools that can simulate images from remote sensors operating in the visible and infrared portions of the electromagnetic spectrum. The testbed is used to explore thermal and hydrologic process interaction at a fine scale to understand the contrast between target and background The testbed provides an opportunity to exploit knowledge of the ground state (boil moisture, soil, or vegetation temperature) and material properties (hydraulic and thermal), to optimize sensor selection and time of flight, and to improve automated target recognition algorithms (ATRs) by limiting false alarms. For example, the testbed provided simulated data to provide field guidance on sensor performance taking into account weather events. The use of simulated data to improve ATR performance is described in detail. C1 [Peters, John; Howington, Stacy; Eslinger, Owen; Fairley, Josh; Ballard, Jerry; Goodson, Ricky; Carpenter, Virginia] USACE, ERDC, Vicksburg, MS USA. RP Peters, J (reprint author), USACE, ERDC, Vicksburg, MS USA. EM john.f.peters@erdc.usace.army.mil; stacy.e.howington@erdc.usace.army.mil; owen.j.eslinger@erdc.usace.army.mil; josh.r.fairley@erdc.usace.army.mil; jerry.ballard@erdc.usace.army.mil; ricky.a.goodson@erdc.usace.army.mil; virginia.l.carpenter@erdc.usace.army.mil NR 3 TC 4 Z9 4 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 978-0-7695-3515-9 PY 2008 BP 349 EP 353 DI 10.1109/DoD.HPCMP.UGC.2008.87 PG 5 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Physics, Applied SC Computer Science; Engineering; Physics GA BJC07 UT WOS:000264661200054 ER PT B AU Cudney, HH Ketcham, SA Albert, DG Parker, MW AF Cudney, Harley H. Ketcham, Stephen A. Albert, Donald G. Parker, Michael W. TI Validating Simulations of Acoustic Propagation in Complex Terrain SO PROCEEDINGS OF THE HPCMP USERS GROUP CONFERENCE 2008 LA English DT Proceedings Paper CT Conference on High Performance Computer Modernization Program CY JUL 14-17, 2008 CL Seattle, WA ID MEDIA AB Comparing numerical simulations to experimental measurements validates aspects of a finite-difference, time-domain code used to simulate seismic and acoustic propagation. In the experiment, C4 explosions in five distinct locations were used as acoustic sources; the resulting pressure pulse propagated over grassy level terrain. Pressure measurements at multiple locations are compared to the three-dimensional simulations. The metrics used in the comparison were variance in amplitudes and arrival times, differences in the time-domain waveforms, and differences in the frequency response functions. The numerical and experimental waveforms agree qualitatively, but there is a relatively large standard deviation in the difference in peak pressure between experiment and simulation. This is likely due to the high-frequency content of the source, which is not captured in the band-limited numerical model. This will be investigated as the next step in the validation. C1 [Cudney, Harley H.; Ketcham, Stephen A.; Albert, Donald G.; Parker, Michael W.] USACE, ERDC, CRREL, Hanover, NH USA. RP Cudney, HH (reprint author), USACE, ERDC, CRREL, Hanover, NH USA. EM Harley.H.Cudney@erdc.usace.army.mil; Stephen.A.Ketcham@erdc.usace.army.mil; Donald.G.Albert@erdc.usace.army.mil; Michael.W.Parker@erdc.usace.army.mil NR 9 TC 2 Z9 2 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 978-0-7695-3515-9 PY 2008 BP 354 EP 358 DI 10.1109/DoD.HPCMP.UGC.2008.54 PG 5 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Physics, Applied SC Computer Science; Engineering; Physics GA BJC07 UT WOS:000264661200055 ER PT B AU Clarke, J Shires, D Vines, J Mark, E AF Clarke, Jerry Shires, Dale Vines, John Mark, Eric TI Asymmetric Core Computing SO PROCEEDINGS OF THE HPCMP USERS GROUP CONFERENCE 2008 LA English DT Proceedings Paper CT Conference on High Performance Computer Modernization Program CY JUL 14-17, 2008 CL Seattle, WA AB The free ride of increasing computing performance by constantly increasing processor frequency is coming to an end. The laws of physics combined with economic forces from the consumer electronics industry have created a revolution in computing which is now clearly headed toward "more" instead of 'faster" processors. At the US Army Research Laboratory we have established a significant effort which is tasked with finding ways to take advantage of multi-core CPUs, Graphical Processing Units (GPUs), Cell Processors, and Field Programmable Gate Arrays (FPGAs) for both traditional physics-based simulations. and real-time battlefield applications. Each of these technologies has various strengths and drawbacks. Our goal is to combine the asymmetric capabilities of the various cores into a complete high performance system. In this paper, we discuss the Asymmetric Core Computing (ACC) Laboratory which we have established along with some of the software tools and applications we are developing. C1 [Clarke, Jerry; Shires, Dale; Vines, John; Mark, Eric] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Clarke, J (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. EM clarke@arl.army.mil; dshires@arl.army.mil; jvines@arl.army.mil; emark@arl.army.mil OI Clark, Jonathan/0000-0002-1162-1238 NR 11 TC 3 Z9 4 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 978-0-7695-3515-9 PY 2008 BP 361 EP 365 DI 10.1109/DoD.HPCMP.UGC.2008.88 PG 5 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Physics, Applied SC Computer Science; Engineering; Physics GA BJC07 UT WOS:000264661200056 ER PT B AU Park, SJ Shires, DR Henz, BJ AF Park, Song Jun Shires, Dale R. Henz, Brian J. TI Coprocessor Computing with FPGA and GPU SO PROCEEDINGS OF THE HPCMP USERS GROUP CONFERENCE 2008 LA English DT Proceedings Paper CT Conference on High Performance Computer Modernization Program CY JUL 14-17, 2008 CL Seattle, WA AB Specialized secondary processing units, such as field programmable gate arrays (FPGAs) and graphics processing units (GPUs), attempt to tackle the time-consuming applications containing high computational requirements. In order to achieve acceleration, FPGAs allow a customizable architecture and Nvidia GPUs offer up to 16 cores with 128 stream processors. The following research presents the experiences of designing integer and floating-point based algorithms for Xilinx FPGAs and programming on NVIDIA graphics card. For test case applications, an encryption function and a sorting algorithm were investigated. The implementation of an encryption algorithm depicts the performance results of an integer application composed of bit operations and a simple sort algorithm tests the effects of a floating-point application containing large numbers of multiple independent sorting instructions. C1 [Park, Song Jun; Shires, Dale R.; Henz, Brian J.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Park, SJ (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. EM song.jun.park@arl.army.mil; dshires@arl.army.mil; bhenz@arl.army.mil NR 10 TC 2 Z9 2 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 978-0-7695-3515-9 PY 2008 BP 366 EP 370 DI 10.1109/DoD.HPCMP.UGC.2008.69 PG 5 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Physics, Applied SC Computer Science; Engineering; Physics GA BJC07 UT WOS:000264661200057 ER PT B AU Renteria, JC Mark, ER AF Renteria, Jose C. Mark, Eric R. TI The Computational Science Environment (CSE) SO PROCEEDINGS OF THE HPCMP USERS GROUP CONFERENCE 2008 LA English DT Proceedings Paper CT Conference on High Performance Computer Modernization Program CY JUL 14-17, 2008 CL Seattle, WA DE HPC; ICE; computational environment AB In an effort to provide a common platform for utilizing and developing data analysis and assessment applications in heterogeneous high performance computing (HPC) environments, the Classified Data Analysis and Assessment Center (CDAAC) has developed the Computational Science Environment (CSE). CSE provides a stable suite of data analysis and assessment tools, applications, and libraries, which are common across most HPC environments and standard 64-bit Linux workstations. CSE also provides an experimental, cutting-edge suite of developer tools that can enhance the data analysis and assessment process. Most importantly, CSE provides a common platform that enables the development of full-featured pot-table HPC applications. This paper provides an overview of how CSE works and highlights some of the benefits of CSE. C1 [Renteria, Jose C.; Mark, Eric R.] USA, Res Lab Raytheon ARL, Aberdeen Proving Ground, MD USA. RP Renteria, JC (reprint author), USA, Res Lab Raytheon ARL, Aberdeen Proving Ground, MD USA. EM jrenteria@arl.army.mil; emark@arl.army.mil NR 5 TC 0 Z9 0 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 978-0-7695-3515-9 PY 2008 BP 382 EP 386 DI 10.1109/DoD.HPCMP.UGC.2008.45 PG 5 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic; Physics, Applied SC Computer Science; Engineering; Physics GA BJC07 UT WOS:000264661200061 ER PT B AU Hay, B Dodge, R Nance, K AF Hay, Brian Dodge, Ronald Nance, Kara BE Jajodia, S Samarati, P Cimato, S TI Using virtualization to create and deploy computer security lab exercises SO PROCEEDINGS OF THE IFIP TC 11/ 23RD INTERNATIONAL INFORMATION SECURITY CONFERENCE LA English DT Proceedings Paper CT 23rd International Information Security Conference held at the 20th World Computer Congress CY SEP 07-10, 2008 CL Milan, ITALY SP IFIP TC 11 AB Providing computer security laboratory exercises enables students to experience and understand the underlying concepts associated with computer security, but there are many impediments to the creation of realistic exercises of this type. Virtualization provides a mechanism for creating and deploying authentic computer security laboratory experiences for students while minimizing the associated configuration time and reducing the associated hardware requirements. This paper provides a justification for using virtualization to create and deploy computer security lab exercises by presenting and discussing examples of applied lab exercises that have been successfully used at two leading computer security programs. The application of virtualization mitigates many of the challenges encountered in using traditional computer laboratory environments for information assurance educational scenarios. C1 [Hay, Brian; Nance, Kara] Univ Alaska, Dept Comp Sci, Fairbanks, AK 99775 USA. [Dodge, Ronald] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Hay, B (reprint author), Univ Alaska, Dept Comp Sci, Fairbanks, AK 99775 USA. EM brian.hay@uaf.edu; ronald.dodge@usma.edu NR 7 TC 2 Z9 2 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-0-387-09698-8 PY 2008 BP 621 EP + PG 2 WC Computer Science, Theory & Methods SC Computer Science GA BID06 UT WOS:000258497700040 ER PT J AU Masrur, MA Wu, HJ Mi, C Chen, ZH MurpheY, YL AF Masrur, M. A. Wu, H-J Mi, C. Chen, Z-H Murphey, Y. L. TI Fault diagnostics in power electronics-based brake-by-wire systems SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART D-JOURNAL OF AUTOMOBILE ENGINEERING LA English DT Article DE fuzzy logic; multi-class fault detection; brake-by-wire; power electronics; d.c. motor; d.c.-to-d.c. converter ID SCHEME; MOTOR AB A d.c.-motor-based brake-by-wire system is studied for the purpose of fault diagnostics of the power electronic switches. The voltage and current generated in the switching circuit under normal and six faulted conditions are observed. A hierarchical fuzzy diagnostic system has been developed to detect certain types of fault condition in any specific solid state power switch at the moment immediately after the occurrence of the fault. The hierarchical fuzzy diagnostic system has been tested and validated using data from both a simulation and a laboratory set-up with a 1/3 hp d.c. motor and a d.c.-to-d.c. converter. The system performance has been compared with two different fuzzy diagnostic systems and the results are presented. The hierarchical fuzzy diagnostic system trained on the simulated model has the capability of detecting certain types of fault condition occurring in a brake-by-wire actuator system set-up in a laboratory in less than 0.0009 s and pinpointing the specific types of fault within less than 0.013 s. C1 [Masrur, M. A.] USA, RDECOM TARDEC, AMSRD TAR R, Warren, MI 48397 USA. [Wu, H-J; Mi, C.; Chen, Z-H; Murphey, Y. L.] Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. RP Masrur, MA (reprint author), USA, RDECOM TARDEC, AMSRD TAR R, MS-264,6501 E 11Mile Rd, Warren, MI 48397 USA. EM masrur@us.army.mil OI Mi, Chris/0000-0002-5471-8953 NR 20 TC 0 Z9 0 U1 0 U2 4 PU PROFESSIONAL ENGINEERING PUBLISHING LTD PI WESTMINISTER PA 1 BIRDCAGE WALK, WESTMINISTER SW1H 9JJ, ENGLAND SN 0954-4070 J9 P I MECH ENG D-J AUT JI Proc. Inst. Mech. Eng. Part D-J. Automob. Eng. PD JAN PY 2008 VL 222 IS D1 BP 1 EP 11 DI 10.1243/09544070JAUT0385 PG 11 WC Engineering, Mechanical; Transportation Science & Technology SC Engineering; Transportation GA 271KS UT WOS:000253787900001 ER PT J AU Grujicic, M Bell, WC Biggers, SB Koudela, KL Tarter, JF Cheeseman, BA AF Grujicic, M. Bell, W. C. Biggers, S. B. Koudela, K. L. Tarter, J. F. Cheeseman, B. A. TI The effect of a carbon-nanotube forest-mat strike face on the ballistic-protection performance of E-glass reinforced poly-vinyl-ester-epoxy composite armour SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS LA English DT Article DE vinyl ester epoxy; carbon nanotubes; composite materials; armour AB In the present work, a ballistic material-model development approach is combined with transient non-linear dynamics simulations of the projectile/ armour interactions to explore the armour-hard-facing potential of multi-walled carbon nanotube (MWCNT) reinforced, polyvinyl-ester-epoxy (PVEE)-matrix composite mats. This approach is applied to improving the ballistic-protection performance of E-glass fibre-mat reinforced PVEE-matrix laminate armour. Two different architectures of the MWCNT-reinforced/PVEE-matrix composite mats were considered: (a) a MWCNT-ply mat structure in which the MWCNT reinforcements are aligned parallel to the armour faces and (b) a MWCNT-forest mat structure in which the MWCNT reinforcements are aligned orthogonally to the armour faces. The projectile/ armour interaction simulation results showed that, at low volume fractions of MWCNTs, both armour architectures yield no discernable increase in the armour ballistic-protection performance as measured by the armour. On the other hand, at high MWCNT volume fractions of MWCNTs, the first armour architecture remained ineffective whereas the second showed a minor improvement in the ballistic-protection performance relative to the corresponding monolithic armour. These results were rationalized using published experimental observations pertaining to the effect of MWCNTs on the in-plane and the through-the-thickness properties of fibre-mat/polymer-matrix composite materials. C1 [Grujicic, M.; Bell, W. C.; Biggers, S. B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Koudela, K. L.; Tarter, J. F.] Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA. [Cheeseman, B. A.] Army Res Lab, Survivabil Mat Branch, Aberdeen, MD USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica@ces.clemson.edu NR 15 TC 8 Z9 8 U1 0 U2 8 PU PROFESSIONAL ENGINEERING PUBLISHING LTD PI WESTMINISTER PA 1 BIRDCAGE WALK, WESTMINISTER SW1H 9JJ, ENGLAND SN 1464-4207 J9 P I MECH ENG L-J MAT JI Proc. Inst. Mech. Eng. Pt. L-J. Mater.-Design Appl. PD JAN PY 2008 VL 222 IS L1 BP 15 EP 27 DI 10.1243/14644207JMDA136 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA 257MU UT WOS:000252804000002 ER PT B AU Martini, WZ AF Martini, W. Z. BE Neugebauer, EAM TI Fibrinogen and Trauma SO PROCEEDINGS OF THE INTERNATIONAL SHOCK CONGRESS LA English DT Proceedings Paper CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society/7th Int Conf Complexity in Acute Illness CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc ID COAGULOPATHY; ACIDOSIS; COAGULATION; PIGS; HYPOTHERMIA; METABOLISM; SWINE C1 USA, Inst Surg Res, Ft Sam Houston, TX 78248 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78248 USA. NR 17 TC 0 Z9 1 U1 0 U2 0 PU MEDIMOND S R L PI 40128 BOLOGNA PA VIA MASERATI 5, 40128 BOLOGNA, 00000, ITALY BN 978-88-7587-413-1 PY 2008 BP 1 EP 5 PG 5 WC Critical Care Medicine SC General & Internal Medicine GA BIW01 UT WOS:000263264200001 ER PT J AU Cassenti, DN McDowell, K AF Cassenti, Daniel N. McDowell, Kaleb TI ACT-R model of a visual ERP experiment SO PSYCHOPHYSIOLOGY LA English DT Meeting Abstract CT 48th Annual Meeting of the Society-for-Psychophysiological-Research CY OCT 01-05, 2008 CL Austin, TX SP Soc Psychophysiol Res C1 [Cassenti, Daniel N.; McDowell, Kaleb] USA, Res Lab, Washington, DC USA. RI McDowell, Kaleb/A-3410-2009 NR 0 TC 0 Z9 0 U1 1 U2 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0048-5772 J9 PSYCHOPHYSIOLOGY JI Psychophysiology PY 2008 VL 45 SU 1 BP S83 EP S83 PG 1 WC Psychology, Biological; Neurosciences; Physiology; Psychology; Psychology, Experimental SC Psychology; Neurosciences & Neurology; Physiology GA 347LX UT WOS:000259144200344 ER PT S AU Meyers, RE Deacon, KS Shih, Y AF Meyers, Ronald E. Deacon, Keith S. Shih, Yanhua BE Meyers, RE Shih, Y Deacon, KS TI Quantum imaging of an obscured object by measurement of reflected photons SO QUANTUM COMMUNICATIONS AND QUANTUM IMAGING VI SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Quantum Communications and Quantum Imaging VI CY AUG 12-14, 2008 CL San Diego, CA ID ENTANGLEMENT; INTERFERENCE; DIFFRACTION; COHERENCE; STATES; LIGHT; FIELD AB Quantum imaging of an obscured object is achieved by the gated coincidence measurement of first the thermal source transverse intensity and second the measured count of scattered and reflected photons that have traversed the obscurant. Interestingly, the CCD camera is looking at the pseudo thermal source of photons not the object. The image does not exist in the mean, but only in the coincidence and has a higher image quality metric than that achieved by a camera viewing the object through the obscurant. C1 [Meyers, Ronald E.; Deacon, Keith S.] Army Res Lab, Adelphi, MD USA. RP Meyers, RE (reprint author), Army Res Lab, Adelphi, MD USA. NR 21 TC 2 Z9 2 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7312-7 J9 P SOC PHOTO-OPT INS PY 2008 VL 7092 AR 70920E DI 10.1117/12.797926 PG 13 WC Instruments & Instrumentation; Optics; Imaging Science & Photographic Technology; Telecommunications SC Instruments & Instrumentation; Optics; Imaging Science & Photographic Technology; Telecommunications GA BIQ87 UT WOS:000262082200007 ER PT S AU Gerhold, M Dhawan, A Vo-Dinh, T AF Gerhold, Michael Dhawan, Anuj Vo-Dinh, Tuan BE Eyink, KG Szmulowicz, F Huffaker, DL TI Geometry-dependent plasmon resonances of metallic nanostructures for enhancement of localized electromagnetic fields around the nanostructures - art. no. 690208 SO QUANTUM DOTS, PARTICLES, AND NANOCLUSTERS V SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Quantum Dots, Particles, and Nanoclusters IV CY JAN 21, 2008 CL San Jose, CA SP SPIE DE finite difference time domain; SERS; Focused Ion Beam; surface enhanced Raman scattering; gold; nanorods; nanostructures; nano-pillar; electromagnetic enhancement ID HEAD AB This paper describes theoretical and experimental evaluations of electromagnetic fields around metallic nanostructures, such as nanorods, nano-pillars, and a collection of nanorods separated by nano-scale distances. Nanostructures having different sizes and shapes were evaluated. The spacing between nanorods; and elliptical nanopillars was varied such that the effect of nanoparticle spacing on the electromagnetic fields in the regions between the nanostructures could be studied. Gold was the metal employed in our work as it demonstrates substantial plasmon excitation and is chemically stable. Calculations of the electromagnetic fields in the vicinity of the different metallic nanostructures were made by employing Finite Difference Time Domain (FDTD). Refractive index of the media surrounding the nanostructures was varied for these calculations. These calculations were carried out at different wavelengths in the visible and near-infrared spectral regimes. In order to fabricate these nanostructures on silica substrates, focused ion beam (FIB) milling was employed. These structures were fabricated on gold-coated planar silica and mica substrates and tips of four mode and multimode optical fibers. In our experimental evaluations of the different metallic nanostructures, surface enhanced Raman scattering (SERS) signals from the different metallic nanostructures were obtained and were correlated to the spacing distance between the different metallic nanostructures. C1 [Gerhold, Michael; Dhawan, Anuj] USA, Res Off, Durham, NC USA. RP Gerhold, M (reprint author), USA, Res Off, Res Triangle Pk, Durham, NC USA. NR 12 TC 0 Z9 0 U1 2 U2 9 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7077-5 J9 P SOC PHOTO-OPT INS PY 2008 VL 6902 BP 90208 EP 90208 DI 10.1117/12.771440 PG 12 WC Nanoscience & Nanotechnology; Optics; Physics, Applied SC Science & Technology - Other Topics; Optics; Physics GA BHO22 UT WOS:000254739300005 ER PT S AU Brandt, HE AF Brandt, Howard E. BE Donkor, EJ Pirich, AR Brandt, HE TI Differential geometry of quantum computing SO QUANTUM INFORMATION AND COMPUTATION VI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Quantum Information and Computation VI CY MAR 19-20, 2008 CL Orlando, FL SP SPIE DE quantum computing; quantum circuits; quantum complexity; differential geometry; Riemannian geometry; geodesics AB An expository review is given of recent developments in the differential geometry of quantum computation. Descriptions are given of the appropriate Riemannian geometry of the special unitary unimodular group in 2(n)-dimensions, including the choice of metric, connection, and optimal geodesics for achieving minimal complexity quantum computations. C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM hbrandt@arl.army.mil NR 12 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7167-3 J9 PROC SPIE PY 2008 VL 6976 AR 69760X DI 10.1117/12.785542 PG 10 WC Computer Science, Theory & Methods; Mathematics, Applied; Physics, Multidisciplinary SC Computer Science; Mathematics; Physics GA BIC17 UT WOS:000258327300019 ER PT S AU Brandt, HE AF Brandt, Howard E. BE Donkor, EJ Pirich, AR Brandt, HE TI Model link and knot mapping in quantum electrodynamics SO QUANTUM INFORMATION AND COMPUTATION VI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Quantum Information and Computation VI CY MAR 19-20, 2008 CL Orlando, FL SP SPIE DE quantum electrodynamics; renormaliztion; number theory; transcendental numbers; Riemann zeta function; link theory; knot theory AB A heuristic mapping onto links and knots of Feynman diagrams in quantum electrodynamics at infinitesimal distances is investigated. This model map is formulated by treating the asymptotic photon propagator as composite electron and positron propagators, and exploiting Feynman's picture of positrons as electrons moving backward in time. The mapping is applied to the calculation in Feynman gauge of the divergent part of the inverse charge renormalization constant to sixth order in the bare charge of the electron as an illustration of Kreimer's classification of the divergent part of Feynman diagrams in terms of transcendental numbers and knots. In particular, I elucidate the mapping of a vacuum polarization graph with two crossed photon propagators onto the trefoil knot. C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM hbrandt@arl.army.mil NR 12 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7167-3 J9 PROC SPIE PY 2008 VL 6976 AR 69760N DI 10.1117/12.775740 PG 12 WC Computer Science, Theory & Methods; Mathematics, Applied; Physics, Multidisciplinary SC Computer Science; Mathematics; Physics GA BIC17 UT WOS:000258327300012 ER PT S AU Innocenti, R AF Innocenti, Roberto BE Ranney, KI Doerry, WD TI Urban structures imaging with sparse arrays SO RADIO SENSOR TECHNOLOGY XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Radio Sensor Technology XII CY MAR 18-19, 2008 CL Orlando, FL DE SAR; multi-static; RF AB The Army Research Laboratory (ARL) has been engaged in an effort to support the "See through the Wall" initiative. As part of the effort, we have explored the possibilities and challenges of using data collected by small groups of men-each man equipped with a small, hand-held, Radio Frequency (RF) sensor-to image the interior of buildings. We examine various multi-static combinations of sensors, especially in configurations that allow for imaging a room from different viewing angles, and we demonstrate the capability of these approaches for providing comprehensive information about a building's interior. We examine the consequences of errors in the assumed position of the RF sensors, and we analyze the effects of the degradation of signal coherence due to mistiming. Simulation results are provided to show the potential of this type of sensor arrangement in such a difficult, urban environment. C1 [Innocenti, Roberto] USA, Res Lab, Adelphi, MD 20783 USA. RP Innocenti, R (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7138-3 J9 PROC SPIE PY 2008 VL 6947 AR 69470E DI 10.1117/12.784714 PG 11 WC Telecommunications SC Telecommunications GA BHW86 UT WOS:000257109300011 ER PT S AU Nguyen, L Ressler, M Sichina, J AF Nguyen, Lam Ressler, Marc Sichina, Jeffrey BE Ranney, KI Doerry, WD TI Sensing through the wall imaging using the Army Research Lab ultra-wideband synchronous impulse reconstruction (UWB SIRE) radar SO RADIO SENSOR TECHNOLOGY XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Radio Sensor Technology XII CY MAR 18-19, 2008 CL Orlando, FL DE synthetic aperture radar (SAR); ultra-wideband radar (UWB); sensing through the wall ID SYNTHETIC-APERTURE RADAR AB The U.S. Army Research Laboratory (ARL), as part of a mission and customer funded exploratory program, has developed a new low-frequency, ultra-wideband (UWB) synthetic aperture radar (SAR). The radar is capable of penetrating enclosed areas (buildings) and generating SAR imagery. This supports the U.S. Army's need for intelligence on the configuration, content, and human presence inside these enclosed areas. The radar system is mounted on a ground based vehicle traveling along the road and is configured with an array of antennas pointing toward the enclosed areas of interest. This paper will describe an experiment conducted recently at Aberdeen Proving Ground (APG), Maryland. In this paper we briefly describe the UWB SIRE radar and the test setup in the experiment. We will also describe the signal processing and the image techniques used to produce the SAR imagery. Finally, we will present SAR imagery of the building and its internal structure from different viewing directions. C1 [Nguyen, Lam; Ressler, Marc; Sichina, Jeffrey] USA, Res Lab, AMSRD ARL SE RU, Adelphi, MD 20783 USA. RP Nguyen, L (reprint author), USA, Res Lab, AMSRD ARL SE RU, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 12 TC 11 Z9 11 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7138-3 J9 PROC SPIE PY 2008 VL 6947 AR 69470B DI 10.1117/12.776869 PG 10 WC Telecommunications SC Telecommunications GA BHW86 UT WOS:000257109300008 ER PT S AU Ranney, K Martone, A Nguyen, L Stanton, B Ressler, M Wong, D Koenig, F Tran, C Kirose, G Smith, G Kappra, K Sichina, J AF Ranney, Kenneth Martone, Anthony Nguyen, Lam Stanton, Brian Ressler, Marc Wong, David Koenig, Francois Tran, Chi Kirose, Getachew Smith, Greg Kappra, Karl Sichina, Jeff BE Ranney, KI Doerry, WD TI Recent MTI experiments using ARL's synchronous impulse reconstruction (SIRE) radar SO RADIO SENSOR TECHNOLOGY XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Radio Sensor Technology XII CY MAR 18-19, 2008 CL Orlando, FL DE moving target indication; impulse-based radar AB The Army Research Laboratory (ARL) has recently developed the ground-based synchronous impulse reconstruction (SIRE) radar-a low-frequency radar capable of exploiting both a real antenna array and along-track integration techniques to increase the quality of processed imagery. We have already demonstrated the system's utility by imaging static scenes. In this paper we address the moving target indication (MTI) problem, and we demonstrate the impulse-based system's ability to both detect and locate slowly moving targets. We begin by briefly describing the SIRE system itself as well as the system configuration utilized in collecting the MTI data. Next we discuss the signal processing techniques employed to create the final MTI image. Finally, we present processed imagery illustrating the utility of the proposed method. C1 [Ranney, Kenneth; Martone, Anthony; Nguyen, Lam; Stanton, Brian; Ressler, Marc; Wong, David; Koenig, Francois; Tran, Chi; Kirose, Getachew; Smith, Greg; Kappra, Karl; Sichina, Jeff] USA, Res Lab, Adelphi, MD 20783 USA. RP Ranney, K (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 6 TC 2 Z9 2 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7138-3 J9 PROC SPIE PY 2008 VL 6947 AR 694708 DI 10.1117/12.782921 PG 9 WC Telecommunications SC Telecommunications GA BHW86 UT WOS:000257109300005 ER PT S AU Ranney, K Nguyen, L Ressler, M Stanton, B Wong, D Koenig, F Tran, C Kirose, G Martone, A Smith, G Sichina, J Kappra, K AF Ranney, Kenneth Nguyen, Lam Ressler, Marc Stanton, Brian Wong, David Koenig, Francois Tran, Chi Kirose, Getachew Martone, Anthony Smith, Greg Sichina, Jeff Kappra, Karl BE Ranney, KI Doerry, WD TI Change detection using the synchronous impulse reconstruction (SIRE) radar SO RADIO SENSOR TECHNOLOGY XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Radio Sensor Technology XII CY MAR 18-19, 2008 CL Orlando, FL DE change detection; forward-looking radar ID SYNTHETIC-APERTURE RADAR; LOOK SAR IMAGERY AB Change detection provides a powerful tool for detecting the introduction of weapons or hazardous materials into an area under surveillance, as demonstrated in past work carried out at the Army Research Laboratory (ARL). This earlier work demonstrated the potential for detecting recently emplaced surface landmines using an X-Band, synthetic aperture radar (SAR) sensor. Recent experiments conducted at ARL have extended these change detection results to imagery collected by the synthetic impulse reconstruction (SIRE) radar-a lower-frequency system developed at ARL. In this paper we describe the algorithms adopted for this change detection experiment and present results obtained by applying these algorithms to the SIRE data set. Results indicate the potential for utilizing systems such as the SIRE as surveillance tools. C1 [Ranney, Kenneth; Nguyen, Lam; Ressler, Marc; Stanton, Brian; Wong, David; Koenig, Francois; Tran, Chi; Kirose, Getachew; Martone, Anthony; Smith, Greg; Sichina, Jeff; Kappra, Karl] USA, Res Lab, Adelphi, MD 20783 USA. RP Ranney, K (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7138-3 J9 PROC SPIE PY 2008 VL 6947 AR 69470A DI 10.1117/12.783522 PG 9 WC Telecommunications SC Telecommunications GA BHW86 UT WOS:000257109300007 ER PT S AU Tan, RJ Thomas, JP AF Tan, Robert J. Thomas, J. Pizzillo BE Ranney, KI Doerry, WD TI Ka-Band clutter measurements of urban environments SO RADIO SENSOR TECHNOLOGY XII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Radio Sensor Technology XII CY MAR 18-19, 2008 CL Orlando, FL AB Measurements were performed by The Army Research Laboratory (ARL) to characterize the statistical and discrete radar clutter at Ka-Band frequencies associated with urban environments for the purpose of investigating the associated backscatter physics and to generate statistics of large extended targets. The measurement data will be used to develop waveform and radar signal processing requirements for Ka-Band radar sensors in urban operational environments. The peak Radar Cross Section (RCS) statistics for urban clutter data are presented as Probability Distribution Functions and Cumulative Distribution Functions. C1 [Tan, Robert J.; Thomas, J. Pizzillo] USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Tan, RJ (reprint author), USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7138-3 J9 PROC SPIE PY 2008 VL 6947 AR 694704 DI 10.1117/12.783959 PG 8 WC Telecommunications SC Telecommunications GA BHW86 UT WOS:000257109300001 ER PT J AU Petrick, N Haider, M Summers, RM Yeshwant, SC Brown, L Iuliano, EM Louie, A Choi, JR Pickhardt, PJ AF Petrick, Nicholas Haider, Maruf Summers, Ronald M. Yeshwant, Srinath C. Brown, Linda Iuliano, Edward M. Louie, Adeline Choi, J. Richard Pickhardt, Perry J. TI CT colonography with computer-aided detection as a second reader: Observer performance study SO RADIOLOGY LA English DT Article; Proceedings Paper CT 91st Scientific Assembly and Annual Meeting of the Radiological-Society-of-North-America CY NOV 27-DEC 02, 2005 CL Chicago, IL SP Radiol Soc N Amer ID TOMOGRAPHIC VIRTUAL COLONOSCOPY; POLYP DETECTION; COLONIC POLYPS; LUNG NODULES; POPULATION; FEASIBILITY; DIAGNOSIS; ISSUES; ROC AB Purpose: To evaluate the effect of computer-aided detection (CAD) as second reader on radiologists' diagnostic performance in interpreting computed tomographic (CT) colonographic examinations by using a primary two-dimensional (2D) approach, with segmental, unblinded optical colonoscopy as the reference standard. Materials and Methods: This HIPAA-compliant study was IRB-approved with written informed consent. Four board-certified radiologists analyzed 60 CT examinations with a commercially available review system. Two-dimensional transverse views were used for initial polyp detection, while three-dimensional (3D) endoluminal and 2D multiplanar views were available for problem solving. After initial review without CAD, the reader was shown CAD-identified polyp candidates. The readers were then allowed to add to or modify their original diagnoses. Polyp location, CT Colonography Reporting and Data System categorization, and reader confidence as to the likelihood of a candidate being a polyp were recorded before and after CAD reading. The area under the receiver operating characteristic (ROC) curve (AUC), sensitivity, and specificity were estimated for CT examinations with and without CAD readings by using multireader multicase analysis. Results: Use of CAD led to nonsignificant average reader AUC increases of 0.03, 0.03, and 0.04 for patients with adenomatous polyps 6 mm or larger, 6-9 mm, and 10 mm or larger, respectively (P >=.25); likewise, CAD increased average reader sensitivity by 0.15, 0.16, and 0.14 for those respective groups, with a corresponding decrease in specificity of 0.14. These changes achieved significance for the 6 mm or larger group (P <.01), 6-9 mm group (P <.02), and for specificity (P <.01), but not for the 10 mm or larger group (P <.16). The average reading time was 5.1 minutes +/- 3.4 (standard deviation) without CAD. CAD added an average of 3.1 minutes +/- 4.3 (62%) to each reading (supine and prone positions combined); average total reading time, 8.2 minutes +/- 5.8. Conclusion: Use of CAD led to a significant increase in sensitivity for detecting polyps in the 6 mm or larger and 6-9 mm groups at the expense of a similar significant reduction in specificity. C1 [Haider, Maruf; Summers, Ronald M.; Yeshwant, Srinath C.; Brown, Linda; Louie, Adeline] NIH, Ctr Clin, Dept Diagnost Radiol, Bethesda, MD 20892 USA. [Petrick, Nicholas] US FDA, Natl Inst Biomed Imaging & Bioengn, Ctr Devices & Radiol Hlth, Joint Lab Assessment Med Imaging Syst, Rockville, MD USA. [Iuliano, Edward M.] Georgetown Univ, Sch Med, Dept Radiol, Washington, DC USA. [Choi, J. Richard] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Pickhardt, Perry J.] Univ Wisconsin, Dept Radiol, Sch Med, Madison, WI 53706 USA. RP Summers, RM (reprint author), NIH, Ctr Clin, Dept Diagnost Radiol, Bldg 10,Room 1C351, Bethesda, MD 20892 USA. EM rms@nih.gov FU Intramural NIH HHS NR 22 TC 66 Z9 67 U1 2 U2 7 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0033-8419 J9 RADIOLOGY JI Radiology PD JAN PY 2008 VL 246 IS 1 BP 148 EP 156 DI 10.1148/radiol.2453062161 PG 9 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 257JN UT WOS:000252795300020 PM 18096536 ER PT S AU Linkov, I Shilling, C Slavin, D Shamir, E AF Linkov, I. Shilling, C. Slavin, D. Shamir, E. BE Linkov, I Ferguson, E Magar, VS TI COGNITIVE ASPECTS OF BUSINESS INNOVATION Scientific Process and Military Experience SO REAL-TIME AND DELIBERATIVE DECISION MAKING: APPLICATION TO EMERGING STRESSORS SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Risk, Uncertainly and Decision Analysis for Environmental Security and Non-Chemical Stressors CY APR, 2007 CL Estoril, PORTUGAL SP NATO AB Increasing information richness and the changing sociopolitical environment in recent years have resulted in changes in corporate structure and organization. The growing challenges of organizational and technological complexities require the development of new organizational concepts. The effects of a combination of high complexity and high uncertainty have been recognized before in military settings. To take advantage of new technologies and manage information complexity, a theory of network-centric operations (NCO) was developed. Mission Command (MC) and NCO formulate organizational structure across functional domains (physical, informational, cognitive, and social), in a way that is also applicable in a business setting. In response to an increase in decision complexity and regulations, academia has developed risk assessment and multicriteria decision analysis (MCDA) tools for use in military and industrial settings. We believe that the combination of military science with MCDA and risk assessment has the potential to dramatically improve the credibility, efficiency and transparency of strategic and tactical decisions in industrial settings. This paper summarizes the military concepts of MC and NCO, and links them with mental modeling, risk assessment, and decision analysis tools. Application of the combined framework to the pharmaceutical industry is also discussed. C1 [Linkov, I.] USA, Engineer Res & Dev Ctr, 83 Winchester St,Suite 1, Brookline, MA 02141 USA. [Shilling, C.] Amarin Neurosci Ltd, Stirling, Scotland. [Slavin, D.] Imperial Coll London, Inst Biomed Engn, London, England. [Shamir, E.] Inst Natl Strateg Studies, Tel Aviv, Israel. RP Linkov, I (reprint author), USA, Engineer Res & Dev Ctr, 83 Winchester St,Suite 1, Brookline, MA 02141 USA. EM igor.linkov@usace.army.mil NR 14 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-1-4020-9024-0 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2008 BP 3 EP + PG 4 WC Environmental Sciences; Operations Research & Management Science SC Environmental Sciences & Ecology; Operations Research & Management Science GA BIP16 UT WOS:000261511600001 ER PT S AU Linkov, I Satterstrom, FK AF Linkov, I. Satterstrom, F. K. BE Linkov, I Ferguson, E Magar, VS TI NANOMATERIAL RISK ASSESSMENT AND RISK MANAGEMENT Review of Regulatory Frameworks SO REAL-TIME AND DELIBERATIVE DECISION MAKING: APPLICATION TO EMERGING STRESSORS SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Risk, Uncertainly and Decision Analysis for Environmental Security and Non-Chemical Stressors CY APR, 2007 CL Estoril, PORTUGAL SP NATO ID MULTICRITERIA DECISION-ANALYSIS; ACCEPTABILITY ANALYSIS; HEALTH IMPLICATIONS; IN-VITRO; NANOPARTICLES; NANOTOXICOLOGY; PARTICLES; EXPOSURE AB Managing emerging risks, such as those posed by nanotechnology, is a challenge that requires carefully balancing largely unknown benefits and risks. Here we review current nanomaterial risk management frameworks and related documents, with a focus on identifying and assessing gaps in their coverage. We do so using a regulatory pyramid, with self-regulation at the pyramid base and prescriptive legislation at its apex. We find that appropriate regulatory tools, especially at the bottom of the regulatory pyramid, are largely lacking. In addition, we recommend that regulatory agencies employ an adaptive, tiered framework to manage nanotechnology risk. The framework should utilize multiple tools at different levels of the pyramid, with specific tools chosen on a case-by-case basis. C1 [Linkov, I.] USA, Engineer Res & Dev Ctr, 83 Winchester St,Suite 1, Brookline, MA 02446 USA. [Satterstrom, F. K.] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Linkov, I (reprint author), USA, Engineer Res & Dev Ctr, 83 Winchester St,Suite 1, Brookline, MA 02446 USA. EM Igor.Linkov@usace.army.mil NR 52 TC 6 Z9 6 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-1-4020-9024-0 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2008 BP 129 EP + PG 5 WC Environmental Sciences; Operations Research & Management Science SC Environmental Sciences & Ecology; Operations Research & Management Science GA BIP16 UT WOS:000261511600008 ER PT S AU Grebenkov, A Yakushau, A Lukashevich, A Sullivan, T Linkov, I AF Grebenkov, A. Yakushau, A. Lukashevich, A. Sullivan, T. Linkov, I. BE Linkov, I Ferguson, E Magar, VS TI DECISION EVALUATION FOR COMPLEX ENVIRONMENTAL RISK NETWORKED SYSTEMS (DECERNS) Cost/Benefit Module and Application to Wildlife Reserve Management SO REAL-TIME AND DELIBERATIVE DECISION MAKING: APPLICATION TO EMERGING STRESSORS SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Risk, Uncertainly and Decision Analysis for Environmental Security and Non-Chemical Stressors CY APR, 2007 CL Estoril, PORTUGAL SP NATO AB Decision Evaluation in Complex Risk Network Systems (DECERNS) is a computerized decision support system with the objective of providing a methodology, computer models and software tools that facilitate decision-making for sustainable land use planning, sediment management, and related issues. Cost-benefit analysis (CBA) is an essential component of environmental assessments. This approach introduces costs (i.e., monetary equivalents) of ecosystem services, but management decisions often require decision makers to integrate heterogeneous technical information with values and judgments. This paper introduces a CBA module developed as part of DECERNS and describes its linkages with a multicriteria decision analysis (MCDA) module that allows integration of monetized parameters with expert-driven estimates and ecological values of stakeholders that may be difficult to monetize. We describe the model's application to selection of land use alternatives for the Dikoye and Zvanets wildlife sanctuaries in Belarus. C1 [Grebenkov, A.; Yakushau, A.; Lukashevich, A.] Joint Inst Power & Nucl Res Sosny, Minsk, Byelarus. [Sullivan, T.] Brookhaven Natl Lab, Upton, NY 11973 USA. [Linkov, I.] US Army Engineer Res & Dev Ctr, Concord, MA USA. RP Grebenkov, A (reprint author), Joint Inst Power & Nucl Res Sosny, Minsk, Byelarus. EM tsullivan@bnl.gov; ilinkov@yahoo.com NR 6 TC 1 Z9 1 U1 1 U2 2 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-1-4020-9024-0 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2008 BP 315 EP + PG 3 WC Environmental Sciences; Operations Research & Management Science SC Environmental Sciences & Ecology; Operations Research & Management Science GA BIP16 UT WOS:000261511600020 ER PT S AU Levner, E Ganoulis, J De Pablo, DAL Linkov, I AF Levner, E. Ganoulis, J. De Pablo, D. Alcaide Lopez Linkov, I. BE Linkov, I Ferguson, E Magar, VS TI SUSTAINABLE MANAGEMENT OF WATER RESOURCES AND MINIMIZATION OF ENVIRONMENTAL RISKS A Multi-Portfolio Optimization Model SO REAL-TIME AND DELIBERATIVE DECISION MAKING: APPLICATION TO EMERGING STRESSORS SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Risk, Uncertainly and Decision Analysis for Environmental Security and Non-Chemical Stressors CY APR, 2007 CL Estoril, PORTUGAL SP NATO ID REUSE AB This paper alms to analyze options for the sustainable development for the Dead Sea Basin. It presents a model based on the green supply chain paradigm and multi-portfolio selection of strategies for sustainable development and mitigating environmental risks. The underlying assumption is that more sustainable development solutions exist than today's scenario of water treatment and distribution in the basin. The integrated sustainable water management model provides security and coordination of risks of the stakeholders in the basin. The developed model combines the economic, physical, and social conditions of water use in the region. C1 [Levner, E.] Holon Inst Technol, IL-58102 Holon, Israel. [Ganoulis, J.] Aristotle Univ Thessaloniki, Dept Civil Engn, UNESCO Chair and Network INWEB, Thessaloniki 54124, Greece. [De Pablo, D. Alcaide Lopez] Univ la Laguna, E-38207 San Cristobal de la Laguna, Spain. [Linkov, I.] US Army Engineer Res & Dev Ctr, Brookline 02446, MA USA. RP Levner, E (reprint author), Holon Inst Technol, IL-58102 Holon, Israel. EM levner@hit.ac.il; iganouli@civil.auth.gr; dalcaide@ull.es; Igor.Linkov@usace.army.mil RI Alcaide Lopez de Pablo, David/F-2709-2012 OI Alcaide Lopez de Pablo, David/0000-0001-9056-2194 NR 24 TC 0 Z9 0 U1 1 U2 3 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-1-4020-9024-0 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2008 BP 329 EP + PG 4 WC Environmental Sciences; Operations Research & Management Science SC Environmental Sciences & Ecology; Operations Research & Management Science GA BIP16 UT WOS:000261511600021 ER PT S AU Zunino, JL Skelton, DR Marinis, RT Klempner, AR Hefti, P Pryputniewicz, RJ AF Zunino, James L., III Skelton, Donald R. Marinis, Ryan T. Klempner, Adam R. Hefti, Peter Pryputniewicz, Ryszard J. BE Hartzell, AL Ramesham, R TI Development of nondestructive testing/evaluation methodology for MEMS - art. no. 688407 SO RELIABILITY, PACKAGING, TESTING, AND CHARACTERIZATION OF MEMS/MOEMS VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Reliability, Packaging, Testing, and Characterization of MEMS/MOEMS VII CY JAN 21-22, 2008 CL San Jose, CA SP SPIE, Boston Univ, Photon Ctr DE MEMS; optoelectronic methodology; environmental stresses; vibration and thermal operating conditions; NDT; quantitative characterization; optimum performance; survivability; reliability ID DISPLACEMENTS AB Development of MEMS constitutes one of the most challenging tasks in today's micromechanics. In addition to design, analysis, and fabrication capabilities, this task also requires advanced test methodologies for determination of functional characteristics of MEMS to enable refinement and optimization of their designs as well as for demonstration of their reliability. Until recently, this characterization was hindered by lack of a readily available methodology. However, using recent advances in photonics, electronics, and computer technology, it was possible to develop a NonDestructive Testing (NDT) methodology suitable for evaluation of MEMS. In this paper, an optoelectronic methodology for NDT of MEMS is described and its application is illustrated with representative examples; this description represents work in progress and the results are preliminary. This methodology provides quantitative full-field-of-view measurements in near real-time with high spatial resolution and nanometer accuracy. By quantitatively characterizing performance of MEMS, under different vibration, thermal, and other operating conditions, specific suggestions for their improvements can be made. Then, using the methodology, we can verify the effects of these improvements. In this way, we can develop better understanding of functional characteristics of MEMS, which will ensure that they are operated at optimum performance, are durable, and are reliable. C1 [Zunino, James L., III; Skelton, Donald R.] USA, RDE Command, AMSRD AAR AEE P, Energet Warheads & Environm Tech USA Corros Off M, Picatinny Arsenal, NJ 07806 USA. RP Zunino, JL (reprint author), USA, RDE Command, AMSRD AAR AEE P, Energet Warheads & Environm Tech USA Corros Off M, Bldg 60, Picatinny Arsenal, NJ 07806 USA. NR 35 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7059-1 J9 P SOC PHOTO-OPT INS PY 2008 VL 6884 BP 88407 EP 88407 DI 10.1117/12.759659 PG 12 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics SC Engineering; Science & Technology - Other Topics; Optics GA BHS41 UT WOS:000255942000005 ER PT S AU Zunino, JL Skelton, DR Robinson, C AF Zunino, James L., III Skelton, Donald R. Robinson, Charles BE Hartzell, AL Ramesham, R TI Reliability testing & analysis of Safing & Arming devices for Army fuzes - art. no. 68840C SO RELIABILITY, PACKAGING, TESTING, AND CHARACTERIZATION OF MEMS/MOEMS VII SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Reliability, Packaging, Testing, and Characterization of MEMS/MOEMS VII CY JAN 21-22, 2008 CL San Jose, CA SP SPIE, Boston Univ, Photon Ctr DE MEMS; Army; Safing & Arming; Fuze; survivability; reliability; measurement techniques AB To address the lack of micro-electro-mechanical systems (MEMS) reliability data as well as a standardized methodology for assessing reliability, the Metallic Materials Technology Branch at Picatinny Arsenal has initiated a MEMS Reliability Assessment Program. This lack of data has been identified as a barrier to the utilization the MEMS in Department of Defense (DoD) systems. Of particular concern are the impacts of long-term storage and environmental exposure on the reliability of devices. Specific objectives of the Metallic Materials Technology Branch (MMTB) program include: Identify MEMS devices to be utilized in weapon systems Determine the relevant categories of MEMS materials, technologies and designs in these applications Assess the operational environments in which the military MEMS device may be utilized Analyze the compatibility of MEMS devices with energetic and other hazardous materials Identify physics of failure, failure mechanisms and failure rates Develop accelerated test protocols for assessing the reliability of MEMS according to the categories Develop of reliability models for these devices Conduct testing and modeling on representative devices of interest to Army and DoD Develop of a methodology and capability for conducting independent assessments of reliability that cannot be obtained from private industry In support of this effort, some testing has been performed on prototype mechanical Safing and Arming (S&A) devices for the 25-min XM25 Air Burst Weapon. ne objective is to test the S&A as a representative device for the identification of potential failure modes and effects for devices of the same class. Information derived from this testing will be used to develop standardized test protocols, formulate reliability models and establish design criteria and to identify critical parameters in support of the S&A development effort. To date, Environmental Stress Screening (ESS) tests have been performed on samples of the device. Along with the ESS testing, a failure modes and effects analysis has been developed and reliability modeling is under way. C1 [Zunino, James L., III; Skelton, Donald R.] USA, RDE Command, Attn AMSRD AAR AEE P, Energet Warheads & Environm Technol,Corros Off,Me, Picatinny Arsenal, NJ 07806 USA. RP Zunino, JL (reprint author), USA, RDE Command, Attn AMSRD AAR AEE P, Energet Warheads & Environm Technol,Corros Off,Me, Picatinny Arsenal, NJ 07806 USA. NR 18 TC 1 Z9 1 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7059-1 J9 P SOC PHOTO-OPT INS PY 2008 VL 6884 BP C8840 EP C8840 DI 10.1117/12.765221 PG 12 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Optics SC Engineering; Science & Technology - Other Topics; Optics GA BHS41 UT WOS:000255942000010 ER PT S AU Ryerson, CC Koenig, GG Reeborst, AL Scott, FR AF Ryerson, Charles C. Koenig, George G. Reeborst, Andrew L. Scott, Forrest R. BE Feltz, FW Murray, JJ TI Concept, simulation, and instrumentation for radiometric inflight icing detection SO Remote Sensing Applications for Aviation Weather Hazard Detection and Decision Support SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Remote Sensing Applications for Aviation Weather Hazard Detection and Decision Support CY AUG 13-14, 2008 CL San Diego, CA SP SPIE DE Millimeter wave; radiometry; icing; polarimeter; RADTRAN; liquid water content; neural network AB The multi-agency Flight in Icing Remote Sensing Team (FIRST), a consortium of the National Aeronautics and Space Administration (NASA), the Federal Aviation Administration (FAA), the National Center for Atmospheric Research (NCAR), the National Oceanographic and Atmospheric Administration (NOAA), and the Army Corps of Engineers (USACE), has developed technologies for remotely detecting hazardous inflight icing conditions. The USACE Cold Regions Research and Engineering Laboratory (CRREL) assessed the potential of onboard passive microwave radiometers for remotely detecting icing conditions ahead of aircraft. The dual wavelength system differences the brightness temperature of Space and clouds, with greater differences potentially indicating closer and higher magnitude Cloud Liquid Water Content (CLWC). The Air Force RADiative TRANsfer model (RADTRAN) was enhanced to assess the flight track sensing concept, and a "flying" RADTRAN was developed to simulate a radiometer system flying through simulated clouds. Neural network techniques were developed to invert brightness temperatures and obtain integrated cloud liquid water. In addition, a dual wavelength Direct-Detection Polarimeter Radiometer (DDPR) system was built for detecting hazardous drizzle drops. This paper reviews technology development to date and addresses initial polarimeter performance. C1 [Ryerson, Charles C.; Koenig, George G.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Ryerson, CC (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM charles.c.ryerson@usace.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7308-0 J9 P SOC PHOTO-OPT INS PY 2008 VL 7088 AR 70880L DI 10.1117/12.794070 PG 14 WC Instruments & Instrumentation; Remote Sensing; Optics; Transportation Science & Technology SC Instruments & Instrumentation; Remote Sensing; Optics; Transportation GA BIS78 UT WOS:000262473000015 ER PT S AU Mlakar, PF Dusenberry, DD Harris, JR Haynes, G Phan, LT Sozen, MA AF Mlakar, Paul F. Dusenberry, Donald D. Harris, James R. Haynes, Gerald Phan, Long T. Sozen, Mete A. BE Pasman, HJ Kirillov, IA TI The pentagon building performance in the 9/11 crash SO RESILIENCE OF CITIES TO TERRORIST AND OTHER THREATS: LEARNING FROM 9/11 AND FURTHER RESEARCH ISSUES SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Urban Structures Resilience under Multi-Hazard Threats - Lessons of 9/11 and Research Issues for Future Work CY JUL 16-18, 2007 CL Moscow, RUSSIA SP NATO Sci Peace & Secur Comm DE pentagon building; 9/11; progressive collapse AB Following the 9/11 crash of an airliner at tile Pentagon, the American Society of Civil Engineers established a team to study the response of the structure. The team reviewed available information on the structure, the crash loading, and the resulting damage. The team then analyzed tile essential features of column response to impact, the residual frame capacity, and the structural response to tile fire. Plausible mechanisms for the response of the structure to the crash were determined and recommendations were offered for the future design and construction of all buildings. C1 [Mlakar, Paul F.] US Army, Corps Engineers, Vicksburg, MS 39180 USA. [Dusenberry, Donald D.] Simpson Gumpertz & Heger, Waltham, MA USA. [Harris, James R.] J R Harris & Co, Denver, CO USA. [Haynes, Gerald] Bereau Alcohol, Firearms & Explos, Washington, DC USA. [Phan, Long T.] Natl Inst Stand & Technol, Gaithersburg, MD USA. [Sozen, Mete A.] Purdue Univ, W Lafayette, IN 47907 USA. RP Mlakar, PF (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Road, Vicksburg, MS 39180 USA. EM Paul.F.Mlakar@erdc.usace.army.mil NR 2 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-1-4020-8487-4 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2008 BP 113 EP + DI 10.1007/978-1-4020-8489-8_6 PG 2 WC Engineering, Civil; Environmental Sciences; Environmental Studies; Planning & Development; Social Issues SC Engineering; Environmental Sciences & Ecology; Public Administration; Social Issues GA BIC08 UT WOS:000258323700006 ER PT J AU Shumway, NM Wilson, RL Howard, RS Parker, JM Eliasson, AH AF Shumway, Nathan M. Wilson, Ramey L. Howard, Robin S. Parker, Joseph M. Eliasson, Arn H. TI Presence and treatment of air hunger in severely ill patients SO RESPIRATORY MEDICINE LA English DT Article DE air hunger; dyspnea; end-of-life; terminal condition ID CANCER-PATIENTS; DYSPNEA; CARE; LIFE; END AB Air hunger at end-of-life poses challenges to providers who attempt to comfort while not diminishing mental capacities. We examined the presence, methods of assessment, and treatment of air hunger. This observational study prospectively screened 198 consecutive medicine admissions for increased risk of near-term death. These patients in turn were screened for dyspnea. Patients screening positive were assessed on admission and the next day with the Visual Analog Scale (VAS), modified Borg Scale, and the American Thoracic Society (ATS) Shortness of Breath Scale. Additionally, resident physician opinions of patient dyspnea level were assessed using the same tools. Treatments focused on alleviating air hunger were recorded. Thirty-nine percent of patients were at risk for near-term death and of these, 53% (95% CI: 41-65%) reported air hunger. All dyspnea scales improved to a statistically and clinically significant degree (Borg p = 0.007, VAS p<0.0005, ATS p = 0.008). There was statistically significant agreement between Borg-VAS and between Borg-ATS with a trend toward significance with ATS-VAS. Physician assessment of dyspnea showed poor agreement with patients. A median of three treatments were received by patients but dyspnea improvement did not correlate with the type, number, or specific combination of therapies. Dyspnea is common near end-of-life. Borg or VAS scales appear useful in assessing terminal dyspnea and can be employed in assessing terminal air hunger. No individual treatment or combination of treatments significantly improved patients' dyspnea. However, air hunger significantly improved with hospitalization. Published by Elsevier Ltd. C1 [Shumway, Nathan M.] Brooke Army Med Ctr, Dept Med, Hematol & Oncol Serv, Ft Sam Houston, TX 78234 USA. [Wilson, Ramey L.] Womack Army Med Ctr, Dept Med, Ft Bragg, NC USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Biomet Serv, Washington, DC 20307 USA. [Parker, Joseph M.; Eliasson, Arn H.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Shumway, Nathan M.; Wilson, Ramey L.; Parker, Joseph M.; Eliasson, Arn H.] Univ Hlth Sci, Dept Med, Uniformed Serv, Bethesda, MD 20817 USA. RP Shumway, NM (reprint author), Brooke Army Med Ctr, Dept Med, Hematol & Oncol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM nathan.shumway@us.army.mit NR 14 TC 3 Z9 3 U1 1 U2 2 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0954-6111 J9 RESP MED JI Respir. Med. PD JAN PY 2008 VL 102 IS 1 BP 27 EP 31 DI 10.1016/j.rmed.2007.08.015 PG 5 WC Cardiac & Cardiovascular Systems; Respiratory System SC Cardiovascular System & Cardiology; Respiratory System GA 255CE UT WOS:000252633500004 PM 17935962 ER PT S AU Madaras, EI Anastasi, RF Seebo, JP Studor, G McMakin, DL Nellums, R Winfiree, WP AF Madaras, Eric I. Anastasi, Robert F. Seebo, Jeffrey P. Studor, George McMakin, Douglas L. Nellums, Robert Winfiree, William P. BE Thompson, DO Chimenti, DE TI The potential for imaging in situ damage in inflatable space structures SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOL 27A AND 27B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 34th Annual Review of Progress in Quantitative Nondestructive Evaluation CY JUL 22-27, 2007 CL Golden, CO SP QNDE Programs DE terahertz imaging; millimeter wave imaging; microwave imaging; space NDE; inflatable space structures AB NASA is investigating the use of inflatable habitat structures for orbital transfer and planetary applications. Since space structures are vulnerable to damage from micrometeoroid and orbital debris, it is important to investigate means of detecting such damage. This study is an investigation into methods for performing non-destructive evaluation (NDE) on inflatable habitat modules. Results of this work showed that various electromagnetic imaging modalities from microwaves to terahertz imaging have the greatest potential for a viable, portable, NDE tool which could possibly be deployed aboard an inflatable habitat module. C1 [Madaras, Eric I.; Winfiree, William P.] NASA, Langley Res Ctr, Nondestruct Evaluat Sci Branch, MS 231, Hampton, VA 23681 USA. [Anastasi, Robert F.] NASA, Langley Res Ctr, Nondestruct Evaluat Sci Branch, US Army Res Lab,Vehicle Technol, Hampton, VA 23681 USA. [Seebo, Jeffrey P.] NASA, Langley Res Ctr, Lockheed Martin, Hampton, VA 23681 USA. [Studor, George] NASA, Johnson Space Ctr, Struct Branch, Houston, TX USA. [McMakin, Douglas L.] Pacif Northwest Natl Lab, Appl Phys, Richland, WA 99354 USA. [Nellums, Robert] Sandia Natl Labs, Albuquerque, NM 87185 USA. RP Madaras, EI (reprint author), NASA, Langley Res Ctr, Nondestruct Evaluat Sci Branch, MS 231, Hampton, VA 23681 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0494-6 J9 AIP CONF PROC PY 2008 VL 975 BP 437 EP + PG 2 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA BHN68 UT WOS:000254553700055 ER PT S AU Zalameda, JN Winfree, WP Yost, WT AF Zalameda, J. N. Winfree, W. P. Yost, W. T. BE Thompson, DO Chimenti, DE TI Air coupled acoustic thermography (ACAT) inspection technique SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOL 27A AND 27B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 34th Annual Review of Progress in Quantitative Nondestructive Evaluation CY JUL 22-27, 2007 CL Golden, CO SP QNDE Programs DE thermography; air coupled acoustic thermography (ACAT); sonic thermography AB The scope of this effort is to determine the viability of a new heating technique using a noncontact acoustic excitation source. Because of low coupling between air and the structure, a synchronous detection method is employed. Any reduction in the out of plane stiffness improves the acoustic coupling efficiency and as a result defective areas have an increase in temperature relative to the surrounding area. Hence a new measurement system, based on air-coupled acoustic energy and synchronous detection is presented. An analytical model of a clamped circular plate is given, experimentally tested, and verified. Repeatability confirms the technique with a measurement uncertainty of +/- 6.2 percent. The range of frequencies used was 800 - 2,000 Hertz. Acoustic excitation and consequent thermal detection of flaws in a helicopter blade is examined and results indicate that air coupled acoustic excitation enables the detection of core damage in sandwich honeycomb structures. C1 [Zalameda, J. N.] NASA, Langley Res Ctr, USA, Res Lab, Hampton, VA 23681 USA. [Winfree, W. P.; Yost, W. T.] NASA, Langley Res Lab, Hampton, VA 23681 USA. RP Zalameda, JN (reprint author), NASA, Langley Res Ctr, USA, Res Lab, Hampton, VA 23681 USA. NR 7 TC 3 Z9 3 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0494-6 J9 AIP CONF PROC PY 2008 VL 975 BP 467 EP + PG 2 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA BHN68 UT WOS:000254553700059 ER PT J AU Sullivan, LA Hageman, JB Houk, BA Hughbanks, P Valdez, F AF Sullivan, Lauren A. Hageman, Jon B. Houk, Brett A. Hughbanks, Paul Valdez, Fred, Jr. BE Stanton, TW Magnoni, A TI Structure Abandonment and Landscape Transformation Examples from the Three Rivers Region SO RUINS OF THE PAST: THE USE AND PERCEPTION OF ABANDONED STRUCTURES IN THE MAYA LOWLANDS SE Mesoamerican Worlds-From the Olmecs to the Danzantes LA English DT Article; Book Chapter C1 [Sullivan, Lauren A.] Univ Massachusetts, Dept Anthropol, Boston, MA 02125 USA. [Valdez, Fred, Jr.] Univ Texas Austin, Austin, TX 78712 USA. [Houk, Brett A.] Texas Tech Univ, Dept Sociol Anthropol & Social Work, Lubbock, TX 79409 USA. [Hughbanks, Paul] USA, Corps Engn, New Orleans, LA USA. [Hageman, Jon B.] NE Illinois Univ, Chicago, IL 60625 USA. RP Sullivan, LA (reprint author), Univ Massachusetts, Dept Anthropol, Harbor Campus, Boston, MA 02125 USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU UNIV PRESS COLORADO PI BOULDER PA 5589 ARAPAHOE AVE, STE 206C, BOULDER, CO 80303 USA BN 978-0-87081-888-2 J9 MESOAM WOR PY 2008 BP 91 EP 111 PG 21 WC Anthropology; Archaeology SC Anthropology; Archaeology GA BYO00 UT WOS:000299475300005 ER PT B AU Dorsey, D Carandang, BJ Kam, M Gaughan, C AF Dorsey, David Carandang, Bjorn Jay Kam, Moshe Gaughan, Chris BE Brueckner, S Robertson, P Bellur, U TI Self-Adaptive Dissemination of Data in Dynamic Sensor Networks SO SASO 2008: SECOND IEEE INTERNATIONAL CONFERENCE ON SELF-ADAPTIVE AND SELF-ORGANIZING SYSTEMS, PROCEEDINGS LA English DT Proceedings Paper CT 2nd IEEE International Conference on Self-Adaptive and Self-Organizing Systems CY OCT 20-24, 2008 CL Venice, ITALY SP IEEE, SASO, IEEE Comp Soc AB The distribution of data in large dynamic wireless sensor networks presents a difficult problem due to node mobility, link failures, and traffic congestion. In this paper we propose a framework for adaptive flooding protocols suitable for disseminating data in large-scale dynamic networks without a central controlling entity. The framework consists of cooperating mobile agents and a reinforcement learning component with function approximation and state generalization. A component for agent coordination is provided, as well as rules for agent replication, mutation, and annihilation. We examine the adaptability of this framework to a data dissemination problem in a simulation experiment.(1) C1 [Dorsey, David; Carandang, Bjorn Jay; Kam, Moshe] Drexel Univ, Data Fus Lab, 3141 Chestnut St, Philadelphia, PA 19104 USA. [Gaughan, Chris] US Army, RDECOM, Edgewood Chem Biolog Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Dorsey, D (reprint author), Drexel Univ, Data Fus Lab, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM dave@minerva.ece.drexel.edu; jay@minerva.ece.drexel.edu; kam@minerva.ece.drexel.edu; chris.gaughan@us.army.mil FU US Army Competitive ILIR (In House Laboratory Independent Research); Assistant Secretary of the Army for Acquisition; Logistics; Technology (ASA(ALT)) FX This project was supported in part by a US Army Competitive ILIR (In House Laboratory Independent Research) Project approved by the Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASA(ALT)). NR 23 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 978-0-7695-3404-6 PY 2008 BP 380 EP + DI 10.1109/SASO.2008.61 PG 3 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BIT10 UT WOS:000262480300038 ER PT S AU Damarla, T AF Damarla, Thyagaraju BE Carapezza, EM TI Performance of sensors mounted on a robotic platform for personnel detection SO SENSORS, AND COMMAND, CONTROL, COMMUNICATIONS, AND INTELLIGENCE (C3I) TECHNOLOGIES FOR HOMELAND SECURITY AND HOMELAND DEFENSE VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Sensors, and Command, Control, Communications and Intelligence (C31) Technologies for Homeland Security and Homeland Defense VI CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE personnel detection; acoustic; seismic; PIR; video sensors; platform noise reduction AB Multi-modal sensor suite mounted on a mobile platform such as a robot has several advantages. The robot can be sent into a cave or a cleared building to observe and determine the presence of unwanted people prior to entering those facilities. The robotic platform poses several challenges, for example, it can be noisy while it is in motion. Its electrical activity might interfere with the magnetic and electric field sensors. Its vibrations may induce noise into seismic sensors. We study the performance of acoustic, seismic, passive infrared (PIR), magnetic, electrostatic and video sensors for detection of personnel mounted on a robotic platform such as a Packbot. The study focuses on the quality of sensor data collected. In turn, the study would determine whether additional processing of data is required to mitigate the platform induced noise for detection of personnel. In particular, the study focuses on the following: Whether different sensors interfere with one another operating in close proximity, for example, the effect on magnetic and electrostatic sensors. Comparison of personnel detection algorithms developed for mobile platform and stationary sensor suite in terms of probability of detection, false alarms, and effects of fusion. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Damarla, T (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM rdamarla@arl.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7134-5 J9 PROC SPIE PY 2008 VL 6943 AR 694309 DI 10.1117/12.776895 PG 6 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications GA BHY04 UT WOS:000257370800006 ER PT S AU Desai, S Grasing, D Morcos, A Hohil, M AF Desai, Sachi Grasing, David Morcos, Amir Hohil, Myron BE Carapezza, EM TI Artillery/mortar round type classification to increase system situational awareness SO SENSORS, AND COMMAND, CONTROL, COMMUNICATIONS, AND INTELLIGENCE (C3I) TECHNOLOGIES FOR HOMELAND SECURITY AND HOMELAND DEFENSE VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Sensors, and Command, Control, Communications and Intelligence (C31) Technologies for Homeland Security and Homeland Defense VI CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE mortar; artillery; sensor platform; UGS; acoustic sensors; and classification AB Feature extraction methods based on the statistical analysis of the change in event pressure levels over a period and the level of ambient pressure excitation facilitate the development of a robust classification algorithm. The features reliably discriminates mortar and artillery variants via acoustic signals produced during the launch events. Utilizing acoustic sensors to exploit the sound waveform generated from the blast for the identification of mortar and artillery variants as type A, etcetera through analysis of the waveform. Distinct characteristics arise within the different mortar/artillery variants because varying HE mortar payloads and related charges emphasize varying size events at launch. The waveform holds various harmonic properties distinct to a given mortar/artillery variant that through advanced signal processing and data mining techniques can employed to classify a given type. The skewness and other statistical processing techniques are used to extract the predominant components from the acoustic signatures at ranges exceeding 3000m. Exploiting these techniques will help develop a feature set highly independent of range, providing discrimination based on acoustic elements of the blast wave. Highly reliable discrimination will be achieved with a feed-forward neural network classifier trained on a feature space derived from the distribution of statistical coefficients, frequency spectrum, and higher frequency details found within different energy bands. The processes that are described herein extend current technologies, which emphasis acoustic sensor systems to provide such situational awareness. C1 [Desai, Sachi; Grasing, David; Morcos, Amir; Hohil, Myron] USA, RDECOM, Picatinny Arsenal, NJ 07806 USA. RP Desai, S (reprint author), USA, RDECOM, Picatinny Arsenal, NJ 07806 USA. EM sachi.desai@us..army.mil; david.grasing@us.army.mil; amir.morcos@us..army.mil; myron.e.hohil@us.army.mil NR 8 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7134-5 J9 PROC SPIE PY 2008 VL 6943 AR 694319 DI 10.1117/12.777935 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications GA BHY04 UT WOS:000257370800038 ER PT S AU Desai, S Morcos, A Tenney, S Mays, B AF Desai, Sachi Morcos, Amir Tenney, Stephen Mays, Brian BE Carapezza, EM TI Integration of Launch/Impact Discrimination algorithm with the UTAMS platform SO SENSORS, AND COMMAND, CONTROL, COMMUNICATIONS, AND INTELLIGENCE (C3I) TECHNOLOGIES FOR HOMELAND SECURITY AND HOMELAND DEFENSE VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Sensors, and Command, Control, Communications and Intelligence (C31) Technologies for Homeland Security and Homeland Defense VI CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE launch; impact; TDOA; event detection; mortar; acoustic sensor array; UTAMS; and classification AB An acoustic array, integrated with an algorithm to discriminate potential Launch (LA) or Impact (IM) events, was augmented by employing the Launch Impact Discrimination (LID) algorithm for mortar events. We develop an added situational awareness capability to determine whether the localized event is a mortar launch or mortar impact at safe standoff distances. The algorithm utilizes a discrete wavelet transform to exploit higher harmonic components of various sub bands of the acoustic signature. Additional features are extracted via the frequency domain exploiting harmonic components generated by the nature of event, i.e. supersonic shrapnel components at impact. The further extrapolations of these features are employed with a neural network to provide a high level of confidence for discrimination and classification. The ability to discriminate between these events is of great interest on the battlefield. Providing more information and developing a common picture of situational awareness. Algorithms exploit the acoustic sensor array to provide detection and identification of IM/LA events at extended ranges. The integration of this algorithm with the acoustic sensor array for mortar detection provides an early warning detection system giving greater battlefield information for field commanders. This paper will describe the integration of the algorithm with a candidate sensor and resulting field tests. C1 [Desai, Sachi; Morcos, Amir] USA, RDECOM, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Desai, S (reprint author), USA, RDECOM, ARDEC, Picatinny Arsenal, NJ 07806 USA. EM sachi.desai@us..army.mil; amir.morcos@us..army.mil; bmays@arl.army.mi; stenney@arl.army.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7134-5 J9 PROC SPIE PY 2008 VL 6943 AR 69431A DI 10.1117/12.777938 PG 11 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications GA BHY04 UT WOS:000257370800039 ER PT S AU Morcos, A Desai, S Quoraishee, S AF Morcos, Amir Desai, Sachi Quoraishee, Shafik BE Carapezza, EM TI Acoustic based system for detection and localization of impulsive generated chemical events SO SENSORS, AND COMMAND, CONTROL, COMMUNICATIONS, AND INTELLIGENCE (C3I) TECHNOLOGIES FOR HOMELAND SECURITY AND HOMELAND DEFENSE VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Sensors, and Command, Control, Communications and Intelligence (C31) Technologies for Homeland Security and Homeland Defense VI CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE Chemical/Biological; TDOA; on-the-move; chemical sensors; acoustic sensors; and classification AB Integrating a sensor suite with ability to discriminate potential Chemical/Biological (CB) events from high-explosive (HE) events employing an acoustic sensor array with a Time Difference of Arrival (TDOA) algorithm. Developing a cueing mechanism for more power intensive and range limited sensing CB techniques. Enabling the event detection algorithm to locate to a blast event using TDOA further information is provided of the event as either Launch/Impact and further as either CB/HE. The point of interest information is gathered to give a viewing window to a range limited chemical sensing system that exploits spectroscopy to determine the contents of the chemical event. The sensor suite is the system that will provide this information on the move while the chemical sensor will have adequate time to determine the contents of the event from a safe stand-off distance. The system exploits acoustic sensors to provide early detection and identification of CB attacks at ranges exceeding 2500m. The integration of these algorithms with the TDOA algorithm provides a complex suite of algorithms that can give early warning detection and highly reliable look direction from a great stand-off distance for a moving vehicle to determine if a candidate blast event is of potential CB type. C1 [Morcos, Amir; Desai, Sachi; Quoraishee, Shafik] USA, RDECOM, Picatinny Arsenal, NJ 07806 USA. RP Morcos, A (reprint author), USA, RDECOM, Picatinny Arsenal, NJ 07806 USA. EM amir.morcos@us.army.mil; sachi.desai@us.army.mil; shafik.quoraishee@us.army.mil NR 4 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7134-5 J9 PROC SPIE PY 2008 VL 6943 AR 69430D DI 10.1117/12.777939 PG 10 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications GA BHY04 UT WOS:000257370800009 ER PT S AU Solomon, L Sim, L Tenney, S AF Solomon, Latasha Sim, Leng Tenney, Stephen BE Carapezza, EM TI Maritime acoustic detection of aircraft to increase flight safety and homeland security: an experimental study SO SENSORS, AND COMMAND, CONTROL, COMMUNICATIONS, AND INTELLIGENCE (C3I) TECHNOLOGIES FOR HOMELAND SECURITY AND HOMELAND DEFENSE VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Sensors, and Command, Control, Communications and Intelligence (C31) Technologies for Homeland Security and Homeland Defense VI CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE acoustics; maritime data collection; source localization AB For several years ARL has studied acoustics to track vehicles, helicopters, Unmanned Aerial Vehicles (UAV) and others targets of interest. More recently these same acoustic sensors were placed on a "simulated" buoy in an attempt to detect and track aircraft over a large body of water. This report will investigate the advantages of using acoustic arrays to track air and water craft from a fixed floating platform as well as potential concerns associated with this technology. Continuous monitoring of aircraft overflight will increase situational awareness while persistent monitoring of commercial and military flight paths increases overall homeland security. C1 [Solomon, Latasha; Sim, Leng; Tenney, Stephen] USA, Res Lab, Adelphi, MD 21244 USA. RP Solomon, L (reprint author), USA, Res Lab, 2800 Powder Mill RD, Adelphi, MD 21244 USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7134-5 J9 PROC SPIE PY 2008 VL 6943 AR 69430Z DI 10.1117/12.784441 PG 6 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications SC Computer Science; Remote Sensing; Imaging Science & Photographic Technology; Telecommunications GA BHY04 UT WOS:000257370800028 ER PT J AU Dubick, M Sondeen, J Medina, L Prince, D Yoshimaru, E Kameneva, M AF Dubick, Michael Sondeen, Jill Medina, Leticia Prince, Dale Yoshimaru, Eriko Kameneva, Marina TI Resuscitation with Hextend alone or with a drag-reducing polymer (DRP) in a swine hemorrhage (HEM) model SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Dubick, Michael; Sondeen, Jill; Medina, Leticia; Prince, Dale; Yoshimaru, Eriko] USA, Inst Surg Res, San Antonio, TX USA. [Kameneva, Marina] Univ Pittsburgh, Pittsburgh, PA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P8 BP 9 EP 9 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500028 ER PT J AU Baer, LA Burns, JW Jordan, BS Sondeen, JL Dubick, MA Chaudry, IH Wade, CE AF Baer, L. A. Burns, J. W. Jordan, B. S. Sondeen, J. L. Dubick, M. A. Chaudry, I. H. Wade, C. E. TI Resuscitation of hemorrhaged sedated mature male miniature swine with 17 beta-estradiol (E2) SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Baer, L. A.; Burns, J. W.; Jordan, B. S.; Sondeen, J. L.; Dubick, M. A.; Chaudry, I. H.; Wade, C. E.] USA, Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P14 BP 11 EP 11 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500034 ER PT J AU Batchinsky, A Jordan, B Beck, J Martini, D Necsoiu, C Meyers, B Lucas, M Cancio, L AF Batchinsky, Andriy Jordan, Bryan Beck, Jenifer Martini, David Necsoiu, Corina Meyers, Belinda Lucas, Michael Cancio, Leopoldo TI Immediate effects of chest trauma on oxygenation in swine SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Batchinsky, Andriy; Jordan, Bryan; Beck, Jenifer; Martini, David; Necsoiu, Corina; Meyers, Belinda; Lucas, Michael; Cancio, Leopoldo] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RI Necsoiu, Corina/A-6255-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P18 BP 12 EP 12 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500038 ER PT J AU Sondeen, JL Prince, MD Medina, L Polykratis, IA Dubick, MA Holcomb, JB AF Sondeen, Jill L. Prince, M. Dale Medina, Leticia Polykratis, I. Amy Dubick, Michael A. Holcomb, John B. TI Comparison of lyophilized swine plasma (LSP) to fresh frozen plasma (FFP) plus two ratios of packed red blood cells (RBC) in a cold, coagulopathic, poly trauma severe hemorrhagic shock swine model SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Sondeen, Jill L.; Prince, M. Dale; Medina, Leticia; Polykratis, I. Amy; Dubick, Michael A.; Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P22 BP 13 EP 14 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500042 ER PT J AU Spinella, PC Perkins, JG Holcomb, JB AF Spinella, Philip C. Perkins, Jeremy G. Holcomb, John B. TI Blood product effect on survival for combat trauma patients in shock SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Spinella, Philip C.; Perkins, Jeremy G.; Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P52 BP 22 EP 23 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500072 ER PT J AU Ryan, KL Rickards, CA Cooke, WH Convertino, VA AF Ryan, K. L. Rickards, C. A. Cooke, W. H. Convertino, V. A. TI Tracking central hypovolemia with linear and nonlinear indices of heart rate variability (HRV) in humans SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Ryan, K. L.; Rickards, C. A.; Convertino, V. A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cooke, W. H.] Univ Texas San Antonio, San Antonio, TX 78249 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P56 BP 24 EP 24 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500076 ER PT J AU Pidcoke, HF Wade, CE Wu, X Baer, LA Wolf, SE AF Pidcoke, H. F. Wade, C. E. Wu, X. Baer, L. A. Wolf, S. E. TI Insulin therapy improves glucose disposal in burned, hindlimb unloaded rats SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. USA, Inst Surg Res, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P86 BP 33 EP 33 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500106 ER PT J AU Atkins, JL Gorbunov, NV Van Duyne, R Kashanchi, F Komarov, AM AF Atkins, J. L. Gorbunov, N. V. Van Duyne, R. Kashanchi, F. Komarov, A. M. TI Iron(II) complexes increase in mesenteric lymph after resuscitation from hemorrhage SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Atkins, J. L.; Gorbunov, N. V.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Van Duyne, R.; Kashanchi, F.; Komarov, A. M.] George Washington Univ, Washington, DC 20037 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P122 BP 44 EP 44 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500142 ER PT J AU Batchinsky, A Terrazas, I Shah, S Bevis, Z Scherer, M Dubick, M Holcomb, J Cancio, L AF Batchinsky, Andriy Terrazas, Irasema Shah, Sarita Bevis, Zachary Scherer, Michael Dubick, Michael Holcomb, John Cancio, Leopoldo TI Immediate effects of chest trauma on coagulation status in swine SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Batchinsky, Andriy; Terrazas, Irasema; Shah, Sarita; Bevis, Zachary; Scherer, Michael; Dubick, Michael; Holcomb, John; Cancio, Leopoldo] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P377 BP 119 EP 119 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500391 ER PT J AU Kheirabadi, BS Perez, MR Cox, A Miranda, N Dubick, MA Holcomb, JB AF Kheirabadi, B. S. Perez, M. R. Cox, A. Miranda, N. Dubick, M. A. Holcomb, J. B. TI Prophylactic recombinant factor VIIa (rFVIIa) treatment prevented coagulopathy and reduced bleeding in rabbits subjected to vascular injuries SO SHOCK LA English DT Meeting Abstract CT 6th Congress of the International-Federation-of-Shock-Societies/31st Annual Conference of the Shock-Society CY JUN 28-JUL 02, 2008 CL Cologne, GERMANY SP Int Federat Shock Soc, Shock Soc C1 [Kheirabadi, B. S.; Perez, M. R.; Cox, A.; Miranda, N.; Dubick, M. A.; Holcomb, J. B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2008 VL 29 SU 1 MA P376 BP 119 EP 119 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SE UT WOS:000256409500390 ER PT J AU Grujicic, M Pandurangan, B Summers, JD Cheeseman, BA Roy, WN Skaggs, RR AF Grujicic, M. Pandurangan, B. Summers, J. D. Cheeseman, B. A. Roy, W. N. Skaggs, R. R. TI Application of the modified compaction material model to the analysis of landmine detonation in soil with various degrees of water saturation SO SHOCK AND VIBRATION LA English DT Article DE detonation; shallow buried mine; blast loading; AUTODYN AB A series of transient non-linear dynamics computational analyses of the explosion phenomena accompanying the detonation of a 100 g C4 mine buried in sand to different depths is carried out using the software package AUTODYN. The mechanical response of sand under high deformation-rate conditions has been represented using the modified compaction material model developed in our recent work [1]. While the mechanical response of the other attendant materials (air, gaseous-detonation products and AISI 1006 mild steel) is accounted for using the material models available in literature. The results obtained (specifically, the temporal evolution of the sand overburden shape and pressure at various locations in air above the detonation site) were compared with their experimental counterparts for a (50wt%-sand/50wt.%-clay) soil obtained recently by Foedinger [2]. The comparison revealed that the modified compaction material model for sand can account reasonably well for the magnitude, spatial distribution and the temporal evolution of the dynamic loads accompanying detonation of shallow-buried mines in soils with various clay and water contents. C1 [Grujicic, M.; Pandurangan, B.; Summers, J. D.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Roy, W. N.] Army Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [Skaggs, R. R.] Army Res Lab, Explos Technol Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu RI Summers, Joshua/B-7362-2009 OI Summers, Joshua/0000-0002-6129-2663 NR 24 TC 15 Z9 15 U1 1 U2 3 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1070-9622 J9 SHOCK VIB JI Shock Vib. PY 2008 VL 15 IS 1 BP 79 EP 99 PG 21 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 259OZ UT WOS:000252949900007 ER PT J AU Johnson, JB Cargile, JD Smith, DM AF Johnson, Jerome B. Cargile, James D. Smith, Donald M. TI Soil properties from low-velocity probe penetration SO SHOCK AND VIBRATION LA English DT Article DE soil strength; soil density; soil compaction; impact penetrator deceleration; soil properties ID PENETROMETER; TARGETS AB A physical model of low-velocity probe penetration is developed to characterize soil by type, strength, maximum compaction, and initial density using Newton's second law to describe the processes controlling probe momentum loss. The probe loses momentum by causing soil failure (strength), accelerating and compacting soil around the probe (inertia), and through frictional sliding at the probe/soil interface (friction). Probe geometry, mass, and impact velocity influences are incorporated into the model. Model predictions of probe deceleration history and depth of penetration agree well with experiments, without the need for free variables or complex numerical simulations. C1 [Johnson, Jerome B.] USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Cargile, James D.; Smith, Donald M.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Johnson, JB (reprint author), USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA. EM Jerome.B.Johnson@erdc.usace.army.mil NR 16 TC 1 Z9 1 U1 0 U2 1 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1070-9622 J9 SHOCK VIB JI Shock Vib. PY 2008 VL 15 IS 2 BP 127 EP 135 PG 9 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 274HM UT WOS:000253992400002 ER PT J AU Velo, AP Gazonas, GA Bruder, E Rodriguez, N AF Velo, Ani P. Gazonas, George A. Bruder, Erwin Rodriguez, Nancy TI RECURSIVE DISPERSION RELATIONS IN ONE-DIMENSIONAL PERIODIC ELASTIC MEDIA SO SIAM JOURNAL ON APPLIED MATHEMATICS LA English DT Article DE dispersion relation; recursive formulas; wave propagation; Floquet theory; periodic layered media ID RESONANT SONIC MATERIALS; WAVE PROPAGATION; PHONONIC CRYSTALS AB A frequency bandgap is a range of wave frequencies that are prohibited from passing through a medium. The dispersion relation, which links the frequency to the wave number, enables us to illustrate the bandgaps. In [E. H. Lee, "A survey of variational methods for elastic wave propagation analysis in composites with periodic structures," in Dynamics of Composite Materials, E. H. Lee, ed., ASME, New York, 1972, pp. 122-138] and [ E. H. Lee and W. H. Yang, SIAM J. Appl. Math., 25 (1973), pp. 492-499] the dispersion relation was studied theoretically for the one-dimensional periodic structure made of two materials arranged symmetrically with respect to the center of the cell. Their dispersion relation formulas can be similarly extended to a multilayered symmetric cell configuration, but not to a general (nonsymmetric) cell configuration. The general model was considered in [M. Shen and W. Cao, J. Phys. D, 33 ( 2000), pp. 1150-1154], where each unit cell of the periodic layered structure contains several sublayers of arbitrary lengths and materials. Using the transfer matrix method, the dispersion relation was successfully derived, involving very lengthy explicit formulas. In this paper, we generalize the work of Lee and Yang and develop recursive dispersion relation formulas for a general cell configuration. The recursive formulas are easy to implement and, through several numerical experiments, successfully corroborate the results of Shen and Cao. C1 [Velo, Ani P.; Bruder, Erwin; Rodriguez, Nancy] Univ San Diego, Dept Math & Comp Sci, San Diego, CA 92110 USA. [Gazonas, George A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Bruder, Erwin] Ecole Speciale Mil St Cyr, Coetquidan, France. RP Velo, AP (reprint author), Univ San Diego, Dept Math & Comp Sci, 5998 Alcala Pk, San Diego, CA 92110 USA. EM avelo@sandiego.edu; gazonas@arl.army.mil OI Gazonas, George/0000-0002-2715-016X NR 24 TC 4 Z9 4 U1 0 U2 12 PU SIAM PUBLICATIONS PI PHILADELPHIA PA 3600 UNIV CITY SCIENCE CENTER, PHILADELPHIA, PA 19104-2688 USA SN 0036-1399 J9 SIAM J APPL MATH JI SIAM J. Appl. Math. PY 2008 VL 69 IS 3 BP 670 EP 689 DI 10.1137/070692595 PG 20 WC Mathematics, Applied SC Mathematics GA 403SU UT WOS:000263103100002 ER PT S AU Bonick, J Marshall, C AF Bonick, James Marshall, Christopher BE Kadar, I TI Statistical, biological, and categorical sensor fusion: an integrated methodology SO SIGNAL PROCESSING, SENSOR FUSION, AND TARGET RECOGNITION XVII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Signal Processing, Sensor Fusion, and Target Recognition XVII CY MAR 17-19, 2008 CL Orlando, FL SP SPIE DE automatic target recognition; category theory; computational intelligence; genetic algorithm; sensor fusion; topos theory AB In this paper, we investigate sensor fusion along three avenues: statistical, biological, and categorical. The first two approaches are analyzed simultaneously to provide a precise and rigorous sensor fusion methodology. The statistical model currently enhances Bayesian methods for tracking, and suggests further application to target identification and fusion-involving both low level feature extraction and higher level sensor output combination. The biological model is also applied to multiple levels of the fusion problem. On the lowest level, it utilizes biologically-inspired results for improved feature extraction. On the higher levels, it develops biologically-inspired evolutionary and agency algorithms for sensor output combination and sensor network analysis. Ultimately, we model the entire fusion process with category theory. Category theory allows for the application of advanced mathematical theory to fusion analysis. In addition to using category theory as a modeling tool, in this paper we adapt categorical logic via topos theory to provide an advanced framework for decision fusion-initially using the topos of graphs. Graphs are a simpler representation. We suggest formulations which will be richer-toward the goal of a theoretically robust and computationally practical sensor fusion system for assisted/automatic target recognition. C1 [Bonick, James] USA, RDECOM CERDEC Night Vis, Ft Belvoir, VA 22060 USA. RP Bonick, J (reprint author), USA, RDECOM CERDEC Night Vis, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7159-8 J9 PROC SPIE PY 2008 VL 6968 AR 69680T DI 10.1117/12.776701 PG 9 WC Engineering, Electrical & Electronic; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Engineering; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BHZ17 UT WOS:000257579700025 ER PT S AU Lelis, AJ Habersat, D Green, R Ogunniyi, A Gurfinkel, M Suehle, J Goldsman, N AF Lelis, A. J. Habersat, D. Green, R. Ogunniyi, A. Gurfinkel, M. Suehle, J. Goldsman, N. BE Dudley, M Johnson, CM Powell, AR Ryu, SH TI Effect of SiC power DMOSFET threshold-voltage instability SO SILICON CARBIDE 2008 - MATERIALS, PROCESSING AND DEVICES SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT Conference on Silicon Carbide - Materials, Processing and Devices held at the 2008 MRS Spring Meeting CY MAR 25-27, 2008 CL San Francisco, CA AB We have performed bias-stress induced threshold-voltage instability measurements on fully processed 4-H SiC power DMOSFETs as a function of bias-stress time, field, and temperature and have observed similar instabilities to those previously reported for lateral SiC MOSFET test structures. This effect is likely due to electrons tunneling into and out of near-interfacial oxide traps that extend spatially into the gate oxide, As long as the threshold voltage is set high enough to preclude the onset of subthreshold drain leakage current in the blocking state, then the primary effect of this instability is to increase the on-state resistance. For well-behaved power DMOSFETs, this would increase the power loss by no more than a few percent. C1 [Lelis, A. J.; Habersat, D.; Green, R.; Ogunniyi, A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Lelis, AJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 10 TC 0 Z9 0 U1 1 U2 1 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DRIVE, WARRENDALE, PA 15088-7563 USA SN 0272-9172 BN 978-1-60511-039-4 J9 MATER RES SOC SYMP P PY 2008 VL 1069 BP 215 EP 220 PG 6 WC Materials Science, Multidisciplinary; Physics, Multidisciplinary SC Materials Science; Physics GA BIE44 UT WOS:000258909700028 ER PT J AU Hobbs, R Laoudi, J Voss, CR AF Hobbs, Reginald Laoudi, Jamal Voss, Clare R. GP European Language Resources Association TI MTriage: Web-enabled Software for the Creation, Machine Translation, and Annotation of Smart Documents SO SIXTH INTERNATIONAL CONFERENCE ON LANGUAGE RESOURCES AND EVALUATION, LREC 2008 LA English DT Proceedings Paper CT 6th International Conference on Language Resources and Evaluation (LREC) CY MAY 28-30, 2008 CL Marrakech, MOROCCO SP European Language Resources Assoc (ELRA), Evaluat & Language Resources Distribut Agcy (ELDA), Ist Linguistica Computazionale (ILC), Nuance, Inst Nederlandse Lexicologie (INL), Microsoft, European Media Lab GmbH, Linguatec, Connexor, Orange, Telisma, AAMT, AMTA, ACL, AFNLP, ALTA, COCOSDA, Oriental COCOSDA, EACL, EAMT, ELSNET, EURALEX, GWA, IAMT, ISCA, KnowledgeWeb, LDC, NEMLAR Network, SIGLEX, TEI, Technolangue French Program, WRITE, Informat Soc & Media, European Commiss, Unit E 2 Content & Knowledge AB Progress in the Machine Translation (MT) research community, particularly for statistical approaches, is intensely data-driven. Acquiring source language documents for testing, creating training datasets for customized MT lexicons, and building parallel corpora for MT evaluation require translators and non-native speaking analysts to handle large document collections. These collections are further complicated by differences in format, encoding, source media, and access to metadata describing the documents. Automated tools that allow language professionals to quickly annotate, translate, and evaluate foreign language documents are essential to improving MT quality and efficacy. The purpose of this paper is present our research approach to improving MT through pre-processing source language documents. In particular, we will discuss the development and use of MTriage, an application environment that enables the translator to markup documents with metadata for MT parameterization and routing. The use of MTriage as a web-enabled front end to multiple MT engines has leveraged the capabilities of our human translators for creating lexicons from NFW (Not-Found-Word) lists, writing reference translations, and creating parallel corpora for MT development and evaluation. C1 [Hobbs, Reginald; Voss, Clare R.] Army Res Lab, Multilingual Comp Branch, Adelphi, MD USA. EM hobbs@arl.army.mil; jlaoudi@arl.army.mil; voss@arl.army.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU EUROPEAN LANGUAGE RESOURCES ASSOC-ELRA PI PARIS PA 55-57, RUE BRILLAT-SAVARIN, PARIS, 75013, FRANCE PY 2008 BP 3337 EP 3343 PG 7 WC Linguistics SC Linguistics GA BGS66 UT WOS:000324028903071 ER PT J AU Voss, CR Laoudi, J Micher, J AF Voss, Clare R. Laoudi, Jamal Micher, Jeffrey GP European Language Resources Association TI Exploitation of an Arabic Language Resource for MT Evaluation: Using Buckwalter-based Lookup Tool to Augment CMU Alignment Algorithm SO SIXTH INTERNATIONAL CONFERENCE ON LANGUAGE RESOURCES AND EVALUATION, LREC 2008 LA English DT Proceedings Paper CT 6th International Conference on Language Resources and Evaluation (LREC) CY MAY 28-30, 2008 CL Marrakech, MOROCCO SP European Language Resources Assoc (ELRA), Evaluat & Language Resources Distribut Agcy (ELDA), Ist Linguistica Computazionale (ILC), Nuance, Inst Nederlandse Lexicologie (INL), Microsoft, European Media Lab GmBH (EML), Linguatec, Connexor, Orange, Telisma, AAMT, AMTA, ACL, AFNLP, ALTA, COCOSDA, Oriental COCOSDA, EACL, EAMT, ELSNET, EURALEX, GWA, IAMT, ISCA, KnowledgeWeb, LDC, NEMLAR Network, SIGLEX, TEI, Technolangue French Program, WRITE, Informat Soc & Media, European Commiss, Unit E 2 Content & Knowledge AB Voss et al. (2006) analyzed newswire translations of three DARPA GALE Arabic-English MT systems at the segment level in terms of subjective judgment scores, automated metric scores, and correlations among these different score types. At this level of granularity, the correlations are weak. In this paper, we begin to reconcile the subjective and automated scores that underlie these correlations by explicitly "grounding" MT output with its Reference Translation (RT) prior to subjective or automated evaluation. The first two phases of our approach annotate {MT, RT} pairs with the same types of textual comparisons that subjects intuitively apply, while the third phase (not presented here) entails scoring the pairs: (i) automated calculation of "MT-RT hits" using CMU aligner from METEOR, (ii) an extension phase where our Buckwalter-based Lookup Tool serves to generate six other textual comparison categories on items in the MT output that the CMU aligner does not identify, and (iii) given the fully categorized RT & MT pair, a final adequacy score is assigned to the MT output, either by an automated metric based on weighted category counts and segment length, or by a trained human judge. C1 [Voss, Clare R.; Laoudi, Jamal; Micher, Jeffrey] Army Res Lab, Adelphi, MD USA. EM voss@arl.army.mil; jlaoudi@arl.army.mil; jmicher@arl.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU EUROPEAN LANGUAGE RESOURCES ASSOC-ELRA PI PARIS PA 55-57, RUE BRILLAT-SAVARIN, PARIS, 75013, FRANCE PY 2008 BP 3498 EP 3505 PG 8 WC Linguistics SC Linguistics GA BGS66 UT WOS:000324028903099 ER PT J AU Subhas, N Vinson, EN Cothran, RL Santangelo, JR Nunley, JA Helms, CA AF Subhas, Naveen Vinson, Emily N. Cothran, R. Lee Santangelo, James R. Nunley, James A., II Helms, Clyde A. TI MRI appearance of surgically proven abnormal accessory anterior-inferior tibiofibular ligament (Bassett's ligament) SO SKELETAL RADIOLOGY LA English DT Article DE ankle; MRI; tibiofibular ligament; accessory ligament; impingement ID ANTEROLATERAL ANKLE IMPINGEMENT; SOFT-TISSUE IMPINGEMENT; TALAR IMPINGEMENT; DIAGNOSIS AB Objective A thickened accessory anterior-inferior tibiofibular ligament (Bassett's ligament) of the ankle can be a cause of ankle impingement. Its imaging appearance is not well described. The purpose of this study was to determine if the ligament could be identified on magnetic resonance imaging (MRI), to determine associated abnormalities, and to determine if MRI could be used to differentiate normal from abnormal. Materials and methods Eighteen patients with a preoperative ankle MRI and an abnormal Bassett's ligament reported at surgery were found retrospectively. A separate cohort of 18 patients was selected as a control population. The presence of Bassett's ligament and its thickness were noted. The integrity and appearance of the lateral ankle ligaments, talar dome cartilage, and anterolateral gutter were also noted. Results In 34 of the 36 cases (94%), Bassett's ligament was identified on MRI. The ligament was seen in all three imaging planes and most frequently in the axial plane. The mean thickness of the ligament in the surgically abnormal cases was 2.37 mm, compared with 1.87 mm in the control with a p value = 0.015 (t test). Nine of the 18 abnormal cases (50%) had talar dome cartilage lesions as a result of contact with the ligament at surgery, with only 3 cases of high-grade defects seen on MRI. Fourteen of the 18 abnormal cases (78%) had of synovitis or scarring in the lateral gutter at surgery, with only 5 cases with scarring seen on MRI. The anterior-inferior tibiofibular ligament was abnormal or torn in 8 of the 18 abnormal cases (44%) by MRI and confirmed in only 3 cases at surgery. Discussion Bassett's ligament can be routinely identified on MRI and was significantly thicker in patients who had it resected at surgery. An abnormal Bassett's ligament is often present in the setting of a normal anterior-inferior tibiofibular ligament. The cartilage abnormalities and synovitis associated with an abnormal Bassett's ligament are poorly detected by conventional MRI. C1 Cleveland Clin, Dept Radiol, Cleveland, OH 44195 USA. Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA. Womack Army Med Ctr, Ft Bragg, NC 28310 USA. Duke Univ, Med Ctr, Div Orthoped Surg, Durham, NC 27710 USA. RP Subhas, N (reprint author), Cleveland Clin, Dept Radiol, 9500 Euclid Ave A21, Cleveland, OH 44195 USA. EM subhasn@ccf.org RI Vinson, Emily/O-1407-2015 NR 15 TC 5 Z9 6 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PD JAN PY 2008 VL 37 IS 1 BP 27 EP 33 DI 10.1007/s00256-007-0390-7 PG 7 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA 234GO UT WOS:000251148900004 PM 17912512 ER PT J AU Boyce, S MacAuslan, J Carr, W Picchioni, D Braun, A Balkin, T AF Boyce, S. MacAuslan, J. Carr, W. Picchioni, D. Braun, A. Balkin, T. TI Automatic detection of changes in speech clarity during sleep deprivation SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Carr, W.] USN, Med Res Ctr, Silver Spring, MD USA. [Boyce, S.] Univ Cincinnati, Cincinnati, OH USA. [MacAuslan, J.] Speech Technol & Appl Res Corp, Bedford, MA USA. [Picchioni, D.; Balkin, T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Carr, W.; Picchioni, D.; Braun, A.] Natl Inst Deafness & Other Commun Disorders, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 341 BP A113 EP A114 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000341 ER PT J AU Carr, W Picchioni, D Balkin, TJ Matute, F Deng, H Paggi, M Braun, AR AF Carr, W. Picchioni, D. Balkin, T. J. Matute, F. Deng, H. Paggi, M. Braun, A. R. TI Effect of sleep deprivation on neural activation during language comprehension and production SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Carr, W.; Picchioni, D.; Matute, F.; Braun, A. R.] USN, Med Res Ctr, Silver Spring, MD USA. [Carr, W.; Picchioni, D.; Matute, F.; Braun, A. R.] Natl Inst Deafness & Other Commun Disorders, Bethesda, MD USA. [Picchioni, D.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Matute, F.] George Washington Univ, Washington, DC USA. [Deng, H.] Thomas Jefferson High Sch Sci & Technol, Alexandria, VA USA. [Paggi, M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 342 BP A114 EP A114 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000342 ER PT J AU Eliasson, AH Lettieri, C Eliasson, A AF Eliasson, A. H. Lettieri, C. Eliasson, A. TI Sleep and academic performance in a community college SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Eliasson, A. H.] Montgomery Coll, Scholars Program, Rockville, MD USA. [Lettieri, C.; Eliasson, A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lettieri, C.; Eliasson, A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 381 BP A127 EP A127 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000381 ER PT J AU Estrada, A Killgore, WD Rouse, T Balkin, TJ Wildzunas, RM AF Estrada, A. Killgore, W. D. Rouse, T. Balkin, T. J. Wildzunas, R. M. TI Total sleep time measured by actigraphy predicts academic performance during military training SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Estrada, A.; Rouse, T.; Wildzunas, R. M.] USA, Aeromed Res Lab, Warfighter Hlth & Performance Div, Ft Rucker, AL USA. [Killgore, W. D.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Killgore, W. D.] Harvard Med Sch, Cognit Neuroimaging Lab, Belmont, MA USA. NR 0 TC 2 Z9 2 U1 0 U2 2 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 404 BP A134 EP A134 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000404 ER PT J AU Gehrman, P Martin, JL Pack, AI Wolson, A Rupp, T Van, RE Bastien, C Harper, R Ellis, J Walsh, J AF Gehrman, P. Martin, J. L. Pack, A., I Wolson, A. Rupp, T. Van, Reen E. Bastien, C. Harper, R. Ellis, J. Walsh, J. TI Does the SRS-sponsored Trainee Symposium Series foster publication and research funding in sleep? SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Gehrman, P.] Univ Sci Philadelphia, Philadelphia, PA USA. [Gehrman, P.; Pack, A., I] Univ Penn, Ctr Sleep & Resp Neurobiol, Philadelphia, PA 19104 USA. [Martin, J. L.] VA Sepulveda Ambulatory Care Ctr, N Hill, CA USA. [Martin, J. L.; Harper, R.] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [Wolson, A.] Coll Holy Cross, Worcester, MA 01610 USA. [Rupp, T.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Van, Reen E.] Harvard Univ, Brigham & Womens Hosp, Div Sleep Med, Sch Med, Boston, MA 02115 USA. [Bastien, C.] Univ Laval, Quebec City, ON, Canada. [Ellis, J.] Univ Surrey, Guildford GU2 5XH, Surrey, England. [Walsh, J.] Sleep Med & Res Ctr, Chesterfield, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 1081 BP A356 EP A356 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001510 ER PT J AU Killgore, WD Lipizzi, EL Killgore, DB Rupp, TL Kamimori, GH Balkin, TJ AF Killgore, W. D. Lipizzi, E. L. Killgore, D. B. Rupp, T. L. Kamimori, G. H. Balkin, T. J. TI Emotional intelligence predicts declines in emotion-based decision-making following sleep deprivation SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD SP Amer Acad Sleep Med, Sleep Res Soc C1 [Killgore, W. D.] Harvard Med Sch, Cognit Neuroimaging Lab, Belmont, MA USA. [Killgore, W. D.; Lipizzi, E. L.; Killgore, D. B.; Rupp, T. L.; Kamimori, G. H.; Balkin, T. J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 403 BP A134 EP A134 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000403 ER PT J AU Killgore, WD Lipizzi, EL Smith, KL Killgore, DB Rupp, TL Kamimori, GH Balkin, TJ AF Killgore, W. D. Lipizzi, E. L. Smith, K. L. Killgore, D. B. Rupp, T. L. Kamimori, G. H. Balkin, T. J. TI Nonverbal intelligence is inversely related to the ability to resist sleep loss SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD SP Amer Acad Sleep Med, Sleep Res Soc C1 [Killgore, W. D.] Harvard Med Sch, Cognit Neuroimaging Lab, Belmont, MA USA. [Killgore, W. D.; Lipizzi, E. L.; Smith, K. L.; Killgore, D. B.; Rupp, T. L.; Kamimori, G. H.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 405 BP A134 EP A135 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000405 ER PT J AU King, C Popovic, D Levendowski, DJ Guerrero, M Olmstead, R Andrada, T Velimirovic, V Yan, N Zavora, T Westbrook, P AF King, C. Popovic, D. Levendowski, D. J. Guerrero, M. Olmstead, R. Andrada, T. Velimirovic, V. Yan, N. Zavora, T. Westbrook, P. TI Validation of changes in forehead venous pressure as a measure of respiratory effort SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [King, C.; Guerrero, M.; Andrada, T.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Popovic, D.; Levendowski, D. J.; Velimirovic, V.; Yan, N.; Zavora, T.; Westbrook, P.] Adv Brain Monitoring Inc, Carlsbad, CA USA. [Olmstead, R.] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 1006 BP A332 EP A332 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001435 ER PT J AU Lettieri, CJ Quast, TN Eliasson, AH AF Lettieri, C. J. Quast, T. N. Eliasson, A. H. TI Eszopiclone improves the quality of polysomnography: A prospective, randomized, placebo-controlled trial SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD SP Amer Acad Sleep Med, Sleep Res Soc C1 [Lettieri, C. J.; Quast, T. N.; Eliasson, A. H.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lettieri, C. J.; Eliasson, A. H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 613 BP A201 EP A202 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001042 ER PT J AU Lettieri, CJ Eliasson, AH Greenburg, DL AF Lettieri, C. J. Eliasson, A. H. Greenburg, D. L. TI Weight loss after bariatric surgery improves, but does not resolve obstructive sleep apnea SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD SP Amer Acad Sleep Med, Sleep Res Soc C1 [Lettieri, C. J.; Eliasson, A. H.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lettieri, C. J.; Eliasson, A. H.; Greenburg, D. L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 612 BP A201 EP A201 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001041 ER PT J AU Lipizzi, EL Richards, J Rupp, TL Balkin, TJ AF Lipizzi, E. L. Richards, J. Rupp, T. L. Balkin, T. J. TI Negative mood alterations with sleep restriction persist into recovery SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD SP Amer Acad Sleep Med, Sleep Res Soc C1 [Lipizzi, E. L.; Rupp, T. L.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Richards, J.] Univ Maryland, College Pk, MD 20742 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 1142 BP A376 EP A377 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001571 ER PT J AU Lipizzi, EL Killgore, WS Rupp, TL Balkin, TY AF Lipizzi, E. L. Killgore, W. S. Rupp, T. L. Balkin, T. Y. TI Risk-taking behavior is elevated during recovery from sleep restriction SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD SP Amer Acad Sleep Med, Sleep Res Soc C1 [Lipizzi, E. L.; Rupp, T. L.; Balkin, T. Y.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Killgore, W. S.] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA 02178 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 1140 BP A376 EP A376 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001569 ER PT J AU Newman, R Killgore, WS Rupp, TL Balkin, TJ AF Newman, R. Killgore, W. S. Rupp, T. L. Balkin, T. J. TI Better baseline olfactory discrimination is associated with worse PVT and MWT performance with sleep restriction and recovery SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Newman, R.; Rupp, T. L.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Killgore, W. S.] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA 02178 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 1139 BP A375 EP A376 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001568 ER PT J AU Picchioni, D Carr, WS Krugler, AL Smith, KL Shamim, SA Sato, S Braun, AR Balkin, TJ AF Picchioni, D. Carr, W. S. Krugler, A. L. Smith, K. L. Shamim, S. A. Sato, S. Braun, A. R. Balkin, T. J. TI Baseline sleep propensity predicts individual differences in performance during subsequent sleep deprivation SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Picchioni, D.; Krugler, A. L.; Smith, K. L.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Carr, W. S.] USN, Med Res Ctr, Silver Spring, MD USA. [Shamim, S. A.; Sato, S.; Braun, A. R.] NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 359 BP A120 EP A120 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000359 ER PT J AU Reid, CT Smith, K Killgore, WS Rupp, TL Balkin, TJ AF Reid, C. T. Smith, K. Killgore, W. S. Rupp, T. L. Balkin, T. J. TI Higher intelligence is associated with less subjective sleepiness during sleep restriction SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Reid, C. T.; Smith, K.; Rupp, T. L.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Killgore, W. S.] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA 02178 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 1138 BP A375 EP A375 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001567 ER PT J AU Rupp, TL Raphael, AA Resensten, NJ Balkin, TJ AF Rupp, T. L. Raphael, A. A. Resensten, N. J. Balkin, T. J. TI Prior sleep extension facilitates learning of a mathematical processing task during sleep restriction and recovery SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Rupp, T. L.; Raphael, A. A.; Resensten, N. J.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 358 BP A119 EP A119 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000358 ER PT J AU Rupp, TL Reichardt, R Wesensten, NJ Balkin, TJ AF Rupp, T. L. Reichardt, R. Wesensten, N. J. Balkin, T. J. TI Sleep extension improves alertness and performance during and following 7 nights of subsequent sleep restriction SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD SP Amer Acad Sleep Med, Sleep Res Soc C1 [Rupp, T. L.; Reichardt, R.; Wesensten, N. J.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 325 BP A108 EP A108 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419000325 ER PT J AU Smith, KL Reid, CT Killgore, WS Rupp, TL Balkin, TL AF Smith, K. L. Reid, C. T. Killgore, W. S. Rupp, T. L. Balkin, T. L. TI Personality factors associated with performance and sleepiness during sleep restriction and recovery SO SLEEP LA English DT Meeting Abstract CT 22nd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 07-12, 2008 CL Baltimore, MD C1 [Smith, K. L.; Reid, C. T.; Rupp, T. L.; Balkin, T. L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Killgore, W. S.] Harvard Univ, Sch Med, Cognit Neuroimaging Lab, Belmont, MA 02178 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2008 VL 31 SU S MA 1141 BP A376 EP A376 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 294PW UT WOS:000255419001570 ER PT J AU Artenstein, AW Martin, T AF Artenstein, Andrew W. Martin, Troy BE Mayer, KH Pizer, HF TI Bioterrorism SO SOCIAL ECOLOGY OF INFECTIOUS DISEASES LA English DT Article; Book Chapter ID PUBLIC-HEALTH MANAGEMENT; SMALLPOX VACCINATION PROGRAM; FATAL INHALATIONAL ANTHRAX; LIVE TULAREMIA VACCINE; BIOLOGICAL WEAPON; FRANCISELLA-TULARENSIS; HISTORICAL-PERSPECTIVE; AEROGENIC IMMUNIZATION; AVIAN INFLUENZA; UNITED-STATES C1 [Artenstein, Andrew W.] Walter Reed Army Inst Res, Sect Protect Immun, Div Retrovirol, Silver Spring, MD USA. [Martin, Troy] Brown Univ, Providence, RI 02912 USA. [Martin, Troy] Brown Univ, Mem Hosp Rhode Isl, Providence, RI 02912 USA. NR 117 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-055714-4 PY 2008 BP 316 EP 350 DI 10.1016/B978-012370466-5.50017-0 PG 35 WC Infectious Diseases SC Infectious Diseases GA BFE74 UT WOS:000319510600014 ER PT J AU Cohen, J Amon, JJ AF Cohen, Jonathan Amon, Joseph J. BE Mayer, KH Pizer, HF TI Governance, human rights and infectious disease: theoretical, empirical and practical perspectives SO SOCIAL ECOLOGY OF INFECTIOUS DISEASES LA English DT Article; Book Chapter ID PUBLIC-HEALTH; EPIDEMIOLOGY; DEMOCRACY; FUTURE C1 [Cohen, Jonathan] Human Rights Watch, HIV AIDS & Human Rights Program, New York, NY USA. [Amon, Joseph J.] Human Rights Watch, HIV AIDS Program, New York, NY USA. [Amon, Joseph J.] US Ctr Dis Control & Prevent, Atlanta, GA USA. [Amon, Joseph J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 41 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-055714-4 PY 2008 BP 408 EP 425 DI 10.1016/B978-012370466-5.50020-0 PG 18 WC Infectious Diseases SC Infectious Diseases GA BFE74 UT WOS:000319510600017 ER PT J AU Grujicic, M Pandurangan, B Qiao, R Cheeseman, BA Roy, WN Skaggs, RR Gupta, R AF Grujicic, M. Pandurangan, B. Qiao, R. Cheeseman, B. A. Roy, W. N. Skaggs, R. R. Gupta, R. TI Parameterization of the porous-material model for sand with different levels of water saturation SO SOIL DYNAMICS AND EARTHQUAKE ENGINEERING LA English DT Article DE sand; material model; detonation; shallow-buried mine; blast loading ID SOILS AB The experimental results for the mechanical response of sand (at different levels of saturation with water) under shock-loading conditions generated by researchers at Cavendish [Bragov AM, Lomunov AK, Sergeichev IV, Tsembelis K, Proud WG. The determination of physicomechanical properties of soft soils from medium to high strain rates, November 2005, in preparation; Chapman DJ. Tsembelis K, Proud WG. The behavior of water saturated sand under shock-loading. In: Proceedings of the 2006 SEM annual conference and exposition on experimental and applied mechanics, vol. 2, 2006.p.834-40] are used to parameterize our recently developed material model for sand [Grujicic M, Pandurangan B, Cheeseman B. The effect of degree of saturation of sand on detonation phenomena associated with shallow-buried and ground-laid mines. J Shock Vib 2006; 13:41-6 1]. The model was incorporated into a 'general-purpose non-linear dynamics simulation program to carry out a number of simulation analyses pertaining to the detonation of a landmine buried in sand and to the interactions of the detonation products, mine fragments and sand ejecta with various targets. A comparison of the computed results with their experimental counterparts revealed a somewhat improved agreement with the experimental results in the case of the present model as compared to the agreement between the widely used porous-material/compaction model for sand and the experiments. (c) 2007 Elsevier Ltd. All rights reserved. C1 Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. Army Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu RI Qiao, Rui/B-2350-2009 OI Qiao, Rui/0000-0001-5219-5530 NR 21 TC 44 Z9 44 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0267-7261 J9 SOIL DYN EARTHQ ENG JI Soil Dyn. Earthq. Eng. PD JAN PY 2008 VL 28 IS 1 BP 20 EP 35 DI 10.1016/j.soildyn.2007.05.00l PG 16 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 238RL UT WOS:000251465100003 ER PT J AU Van Dam, RL Harrison, JBJ Hirschfeld, DA Meglich, TM Li, Y North, RE AF Van Dam, Remke L. Harrison, J. Bruce J. Hirschfeld, Deidre A. Meglich, Todd M. Li, Yaoguo North, Ryan E. TI Mineralogy and magnetic properties of basaltic substrate soils: Kahoolawe and Big Island, Hawaii SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL LA English DT Article ID IRON-OXIDES; SUSCEPTIBILITY AB Magnetic behavior of soils can seriously hamper the performance of geophysical sensors. Currently, we have little understanding of the types of minerals responsible for the magnetic behavior, as well as their distribution in space and evolution through time. This study investigated the magnetic characteristics and mineralogy of Fe-rich soils developed on basaltic substrate in Hawaii. We measured the spatial distribution of magnetic susceptibility (chi(lf)) and frequency dependence (chi(fd)%) across three test areas in a well-developed eroded soil on Kaho'olawe and in two young soils on the Big Island of Hawaii. X-ray diffraction spectroscopy, x-ray fluorescence spectroscopy (XRF), chemical dissolution, thermal analysis, and temperature-dependent magnetic studies were used to characterize soil development and mineralogy for samples from soil pits on Kaho'olawe, surface samples from all three test areas, and unweathered basalt from the Big Island of Hawaii. The measurements show a general increase in magnetic properties with increasing soil development. The XRF Fe data ranged from 13% for fresh basalt and young soils on the Big Island to 58% for material from the B horizon of Kaho'olawe soils. Dithionite-extractable and oxalate-extractable Fe percentages increase with soil development and correlate with chi(lf) and chi(fd)%, respectively. Results from the temperature-dependent susceptibility measurements show that the high soil magnetic properties observed in geophysical surveys in Kaho'olawe are entirely due to neoformed minerals. The results of our studies have implications for the existing soil survey of Kaho'olawe and help identify methods to characterize magnetic minerals in tropical soils. C1 [Van Dam, Remke L.] Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. [Harrison, J. Bruce J.] New Mexico Inst Min & Technol, Dept Earth & Environm Sci, Socorro, NM 87801 USA. [Hirschfeld, Deidre A.] New Mexico Inst Min & Technol, Dept Mat Engn, Socorro, NM 87801 USA. [Meglich, Todd M.; Li, Yaoguo] Colorado Sch Mines, Dept Geophys, Golden, CO 80401 USA. [North, Ryan E.] USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Van Dam, RL (reprint author), Michigan State Univ, Dept Geol Sci, 206 Nat Sci, E Lansing, MI 48824 USA. EM rvd@msu.edu RI Van Dam, Remke/A-2319-2011 NR 34 TC 11 Z9 11 U1 2 U2 10 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA SN 0361-5995 J9 SOIL SCI SOC AM J JI Soil Sci. Soc. Am. J. PD JAN-FEB PY 2008 VL 72 IS 1 BP 244 EP 257 DI 10.2136/sssaj2006.0281 PG 14 WC Soil Science SC Agriculture GA 255TV UT WOS:000252681300030 ER PT J AU Pennington, JC Silverblatt, B Poe, K Hayes, CA Yost, S AF Pennington, Judith C. Silverblatt, Bryan Poe, Ken Hayes, Charolett A. Yost, Sally TI Explosive residues from low-order detonations of heavy artillery and mortar rounds SO SOIL & SEDIMENT CONTAMINATION LA English DT Article DE RDX; TNT; detonation residue; soil contamination; soil remediation ID ENERGETIC COMPOUNDS; DISSOLUTION RATES; TRAINING RANGES; COMPOSITION-B; TNT; RDX AB Low-order detonations are produced by artillery and mortar rounds that fail to function as intended. The unconsumed residual explosive constitutes a potentially significant source of explosives for environmental receptors. The objectives of this study were to relate residue mass to detonation pressure, to define the relationship between the residue mass and distance from the detonation center, and to determine particle size distribution and composition of residues. Three types of mortar and two heavy artillery rounds were detonated by specific donor charges. Detonations were executed on a tarp so that residues could be recovered by sweeping. No consistent relationship was demonstrated between residue mass and measured detonation pressure. Furthermore, no consistent differences in deposition with distance from the detonation center were observed. Most of the recovered mass was in the 12.5-mm size fraction; very little was in the 0.25-mm size fraction. The ratio of RDX to TNT in the original Composition B was conserved in the residues. Results illustrate that significant quantities of explosive residues can result from low-order detonations. The particle size distribution and chemical composition of the explosive residues can be used to evaluate their future environmental fate and transport. C1 [Pennington, Judith C.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Silverblatt, Bryan; Poe, Ken] USN, Explos Ordnance Disposal Technol Div, Indian Head, MD USA. [Hayes, Charolett A.; Yost, Sally] SpecPro Inc, Huntsville, AL USA. RP Pennington, JC (reprint author), 106 Danawood Lane, Vicksburg, MS 39180 USA. EM Judy1Penni@aol.com FU Strategic Environmental Research and Development Program FX We gratefully acknowledge the funding support of the Strategic Environmental Research and Development Program, Mr. Bradley Smith, Executive Director, and Dr. Jeffrey Marqusee, Technical Director. We appreciate the instrumentation provided by Mr. Cornelius Reed, Applied Research Associates, Inc., Littleton, CO. Mr. William Davis, Army Research Laboratory, Blossom Point, MD, is acknowledged for setting the detonations and providing site preparation and maintenance. We also thank the following, who assisted with sample processing and analysis in the Environmental Chemistry Branch, ERDC: Lynn Escalon, Allyson Harrison, Linda Stevenson, Agnes Morrow, Richard A. Karn, and Carolyn Pettway. Permission was granted by the Chief of Engineers to publish this report. NR 26 TC 4 Z9 4 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-0383 J9 SOIL SEDIMENT CONTAM JI Soil. Sediment. Contam. PY 2008 VL 17 IS 5 BP 533 EP 546 DI 10.1080/15320380802306669 PG 14 WC Environmental Sciences SC Environmental Sciences & Ecology GA 341BM UT WOS:000258689200007 ER PT J AU Ramachandran, S Prater, JT Sudhakar, N Kumar, D Narayan, J AF Ramachandran, S. Prater, J. T. Sudhakar, N. Kumar, D. Narayan, J. TI Magnetic properties of epitaxial oxide heterostructures SO SOLID STATE COMMUNICATIONS LA English DT Article DE spintronics : devices exploiting spin polarized transport or integrated magnetic fields; magnetic semiconductors; magnetotransport phenomena; spin transport through interfaces ID ROOM-TEMPERATURE; THIN-FILMS; DEVICE; ZNO AB Diluted Magnetic Semiconductors (DMS) are of great interest as injection sources for spin-polarized currents into semiconductors. Epitaxial devices have been synthesized with an intermediate spacer layer of the same semiconductor (zinc oxide, ZnO) used to produce the DMS material (ZnCoO) ensuring a homoepitaxial junction to help reduce the interface states and conduction mismatch. We observe a large magnetoresistance of about 32% in the devices at low temperatures. The present work suggests that spin polarized transport could be achieved with DMS materials acting as the source of injected spins into a non-magnetic host. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Ramachandran, S.; Prater, J. T.; Sudhakar, N.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, NSF Ctr Adv Mat & Smart Struct, Raleigh, NC 27695 USA. [Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. [Kumar, D.] N Carolina Agr & Tech State Univ, Dept Mech Engn, Greensboro, NC 27411 USA. RP Narayan, J (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, NSF Ctr Adv Mat & Smart Struct, Box 7907, Raleigh, NC 27695 USA. EM j_narayan@ncsu.edu RI Nori, Sudhakar/E-8111-2010; Narayan, Jagdish/D-1874-2009 NR 14 TC 16 Z9 17 U1 0 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1098 J9 SOLID STATE COMMUN JI Solid State Commun. PD JAN PY 2008 VL 145 IS 1-2 BP 18 EP 22 DI 10.1016/j.ssc.2007.10.005 PG 5 WC Physics, Condensed Matter SC Physics GA 245ZC UT WOS:000251976300005 ER PT J AU Graham, JH Krzysik, AJ Kovacic, DA Duda, JJ Freeman, DC Emlen, JM Zak, JC Long, WR Wallace, MP Chamberlin-Graham, C Nutter, JP Balbach, HE AF Graham, John H. Krzysik, Anthony J. Kovacic, David A. Duda, Jeffrey J. Freeman, D. Carl Emlen, John M. Zak, John C. Long, W. Russell Wallace, Michael P. Chamberlin-Graham, Catherine Nutter, Jonathan P. Balbach, Hal E. TI Ant Community Composition Across a Gradient of Disturbed Military Landscapes at Fort Benning, Georgia SO SOUTHEASTERN NATURALIST LA English DT Article ID CANONICAL CORRESPONDENCE-ANALYSIS; FLORIDA UPLAND ECOSYSTEMS; SOIL TEXTURE; BODY-SIZE; LAND-USE; RECOLONIZATION PATTERNS; HABITAT; FORMICIDAE; FOREST; HYMENOPTERA AB Military training, soil texture, and ground cover influence ant communities at Fort Benning, a military installation in west-central Georgia. We sampled 81,237 ground-dwelling ants (47 species in 20 genera) with pitfall traps at 40 sites on a continuum from nearly pristine forest to highly disturbed training areas. We also measured 15 environmental variables related to vegetation and soil. Sites disturbed by military training had fewer trees, less canopy cover, more bare ground, and more compact soils with shallower A-horizons than comparable undisturbed sites. Pheidole bicarinata, Dorymyrmex smithi, and Pogonomyrmex badius dominated the most highly disturbed sites. Competitively submissive myrmicines, such as Aphaenogaster and Cremalogaster, and formicines, such as Camponotus and Formica, were abundant in the undisturbed sites. Solenopsis invicta occurred in all but the least disturbed sites. Ant community composition was a useful indicator of disturbance at Fort Benning. C1 [Graham, John H.; Long, W. Russell; Chamberlin-Graham, Catherine; Nutter, Jonathan P.] Berry Coll, Dept Biol, Mt Berry, GA 30149 USA. [Krzysik, Anthony J.] Prescott Coll, Prescott, AZ 86301 USA. [Kovacic, David A.; Wallace, Michael P.] Univ Illinois, Dept Landscape Architecture, Champaign, IL 61820 USA. [Duda, Jeffrey J.; Emlen, John M.] Western Fisheries Res Ctr, USGS Biol Resources Div, Seattle, WA 98115 USA. [Freeman, D. Carl] Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA. [Zak, John C.] Texas Tech Univ, Dept Biol, Lubbock, TX 79409 USA. [Balbach, Hal E.] USA, ERDC CERL, Champaign, IL 61826 USA. RP Graham, JH (reprint author), Berry Coll, Dept Biol, Mt Berry, GA 30149 USA. EM jgraham@berry.edu RI Duda, Jeffrey/A-7132-2009; OI Duda, Jeffrey/0000-0001-7431-8634; Graham, John/0000-0003-1974-132X FU SERDP (Strategic Environmental Research and Development Program) [CS- 1114B]; Ecosystem Management Project (SEMP); US Department of Defense, Department of Energy,; Environmental Protection Agency FX This research is a component of the Development of Ecological Indicator Guilds for Land Management. project CS- 1114B, sponsored by SERDP (Strategic Environmental Research and Development Program), and is part of the SEKDP Ecosystem Management Project (SEMP). SERDP is a joint program of the US Department of Defense, Department of Energy, and Environmental Protection Agency. Student research assistants of J.H. Graham as well as other costs were funded, in part, by Berry College. Michelle Brown and Lorence Pascoe helped with the fieldwork. In addition, we thank Pete Swiderek, Theresa Davo, and John Brent of Fort Benning, and Hugh Westbury and Patti Kosky of SERDP-SEMP for helping, LIS to Choose sites and to coordinate our work with Fort Benning Range Control. Natural Resources and Fish and Wildlife branches at Fort Benning provided the fire data. Mark Deyrup, Stefan Cover. William Mackay, Jaines Trager, and Joshua King offered numerous suggestions on ant taxonomy, identification, and natural history. Andrea Woodward and Joe MacGown provided useful comments on the manuscript. The use of trade, firm, or corporation names in this publication is for the information and convenience of the reader. Such use does not constitute ail official endorsement or approval by the United States Department of Interior or the United States Geologic Survey of any product or service to the exclusion of others that may be suitable. NR 62 TC 10 Z9 11 U1 1 U2 10 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 EI 1938-5412 J9 SOUTHEAST NAT JI Southeast. Nat. PY 2008 VL 7 IS 3 BP 429 EP 448 DI 10.1656/1528-7092-7.3.429 PG 20 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 357XA UT WOS:000259879300004 ER PT J AU Delaney, DK Pater, LL Carlile, LD Stevenson, DJ Walde, AD AF Delaney, David K. Pater, Larry L. Carlile, Lawrence D. Stevenson, Dirk J. Walde, Andrew D. TI Red-cockaded Woodpecker (Picoides borealis) Response to Nest Depredation by an Eastern Rat Snake (Elaphe alleghaniensis) SO SOUTHEASTERN NATURALIST LA English DT Article ID HABITAT SELECTION; CAVITY TREES; MEAL SIZE; PREDATION; OBSOLETA; NESTLINGS; SPILOIDES; ECOLOGY; PREY AB We report the depreciation of a Picoides borealis (Red-cockaded Woodpecker) nest by an Elaphe alleghaniensis (Eastern Rat Snake). Of 38 banded woodpecker groups monitored by video surveillance during 1998-2000, we documented one nest depredation by an E-astern Rat Snake. Woodpecker visitation to the nest area during the depreciation event increased substantially compared with pre-depredation nesting behavior. Woodpecker visitation to the nest cavity was minimal during the first six hours after the snake was discovered by the adult woodpeckers. Visitation levels by woodpeckers remained higher than pre-depredation levels while the snake remained in the nest cavity. After the snake's departure from the nest, visitation rates dropped below pre-depredation levels. Woodpeckers continued to visit the cavity during the day and roost in the cavity at night for the remaining seven days of surveillance post-depredation. This same banded woodpecker pair nested in the same cavity in 1999 and fledged I female. Overall, we observed a low rate of nest depreciation by rat snakes during this study; only one instance was recorded during more than 15,000 hours of video surveillance. Based oil the proclivity of Red-cockaded Woodpeckers to re-nest in previous nest cavities, and the potential for snakes to re-climb trees based on past successes, resource managers may want to prioritize placement of snake excluder devices or use of bark-shaving at active cavity trees where snake depreciation has occurred, especially if Funding is limited. We urge Ornithologists to continue to incorporate snake research into their avian research to achieve a greater understanding of predator-prey relationships that impact cavity-nesting birds, especially threatened and endangered species such as Red-cockaded Woodpeckers. C1 [Delaney, David K.; Pater, Larry L.] USA, Construct Engn Res Lab, Champaign, IL 61826 USA. [Carlile, Lawrence D.; Stevenson, Dirk J.] Environm Div, Ft Stewart, GA 31314 USA. RP Delaney, DK (reprint author), USA, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM David.Delaney@erdc.usace.army.mil FU US Army Forces Command; Fort Stewart Army Installation; Strategic Environmental Research and Development [CS-1083]; Construction Engineering Research Laboratory FX This study was supported by US Army Forces Command and the Fort Stewart Army Installation with funding from the Strategic Environmental Research and Development Program, under Conservation Project No. CS-1083, and the Construction Engineering Research Laboratory, which is part of the Engineer Research and Development Center for the US Army Corps of Engineers. The Environmental Division at Fort Stewart provided logistical support and conducted woodpecker nest surveys. We thank T. Brewton, H. Erickson, M. Fay, M. Huffman, M. Klich, S. Kovac, B. Platt, and A. Rinker for assisting with data collection; A. Cone, B. MacAllister, L. Nguyen, and C. Smith for reviewing videotapes; and T. Grubb and T. Brewton for their assistance in placing video cameras. We also thank D. Richardson and one anonymous reviewer I or comments that improved the paper. NR 36 TC 1 Z9 1 U1 2 U2 9 PU HUMBOLDT FIELD RESEARCH INST PI STEUBEN PA PO BOX 9, STEUBEN, ME 04680-0009 USA SN 1528-7092 J9 SOUTHEAST NAT JI Southeast. Nat. PY 2008 VL 7 IS 4 BP 753 EP 759 DI 10.1656/1528-7092-7.4.753 PG 7 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 383VV UT WOS:000261703200018 ER PT J AU Moran, DS Evans, RK Hadad, E AF Moran, Daniel S. Evans, Rachel K. Hadad, Eran TI Imaging of lower extremity stress fracture injuries SO SPORTS MEDICINE LA English DT Article ID NEGATIVE BONE-SCAN; QUANTITATIVE COMPUTED-TOMOGRAPHY; OF-THE-LITERATURE; SCINTIGRAPHIC FINDINGS; SHAFT FRACTURE; RADIOGRAPHY; RUNNERS; ATHLETE; CT; SONOGRAPHY AB Stress reactions and stress fractures in the lower extremities occur frequently in military and athletic populations. As the clinical symptoms of stress fracture may mimic other less severe musculoskeletal injuries, the diagnosis of stress fracture can often be delayed. The following article reviews the characteristics, advantages and disadvantages of the various imaging tools available to detect stress fracture of the lower limbs in order to clarify their utility when diagnosing this condition. Plain radiography, the primary imaging tool for diagnosing suspected stress injuries, may not detect stress fracture injury until fracture healing is well underway. In some cases of suspected stress fracture, this delay in diagnosis can lead to catastrophic fracture and surgical intervention. Bone scintigraphy has long been recommended for the diagnosis of stress fracture, claiming that skeletal scintigraphy is 100% sensitive for the detection of stress fracture. However, there is a potential for a false negative examination and findings might be nonspecific as tumours or infections may mimic stress injury. In addition, bone scintigraphy involves ionizing radiation and it should not be used whenever there is an alternative. Computed tomography (CT) provides exquisitely fine osseous detail, but should be reserved only for specific indications because it also involves ionizing radiation. Magnetic resonance (MR) imaging, which is noninvasive, has no ionizing radiation, is more rapidly performed than bone scintigraphy, and should be the method of choice for stress fracture diagnosis whenever it is available. However, using MR imaging demands an experienced diagnostician in order to decrease reported false-positive injuries. The ultrasonography technique, which is being used increasingly in the evaluation of the musculoskeletal system has recently been shown to have some potential in the diagnosis of stress fracture; however, currently the imaging modalities are insufficient. The peripheral quantitative CT (pQCT) device, which has been developed to specifically assess skeletal status of the extremities, provides data on bone geometry, strength and density. However, the pQCT needs further evaluation prior to being considered for use in diagnosis stress changes in bone. This article reviews the utility of each of the imaging modalities currently available to detect stress fracture injuries of the lower extremities, as well as other utilization factors, which include exposure to ionizing radiation, the ability to detect early- and late-stage reactions in the bone and surrounding soft tissues, and the ability to differentiate between different types of bone lesions. C1 [Moran, Daniel S.; Hadad, Eran] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Miltary Performance Div, Natick, MA 01760 USA. RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM dmoran@sheba.health.gov.il NR 58 TC 25 Z9 25 U1 4 U2 16 PU ADIS INT LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW ZEALAND SN 0112-1642 J9 SPORTS MED JI Sports Med. PY 2008 VL 38 IS 4 BP 345 EP 356 PG 12 WC Sport Sciences SC Sport Sciences GA 291PZ UT WOS:000255210600005 PM 18348592 ER PT S AU Rice, BM Sewell, TD AF Rice, Betsy M. Sewell, Thomas D. BE Peiris, SM Piermarini, GJ TI Equilibrium Molecular Dynamics Simulations SO STATIC COMPRESSION OF ENERGETIC MATERIALS SE Shock Wave and High Pressure Phenomena LA English DT Article; Book Chapter ID CRYSTAL-STRUCTURE PREDICTION; REACTIVE FORCE-FIELD; DENSITY-FUNCTIONAL THEORY; DER-WAALS INTERACTIONS; THERMAL-DECOMPOSITION KINETICS; POLYMER-BONDED EXPLOSIVES; SMALL ORGANIC-MOLECULES; EQUATION-OF-STATE; AB-INITIO; LIQUID NITROMETHANE C1 [Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Sewell, Thomas D.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA. RP Rice, BM (reprint author), USA, Res Lab, AMSRL WM BD Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM betsyr@arl.army.mil NR 199 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1434-4904 BN 978-3-540-68146-5 J9 SHOCK WAVE HIGH PRES PY 2008 BP 255 EP 290 DI 10.1007/978-3-540-68151-9_7 D2 10.1007/978-3-540-68151-9 PG 36 WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Materials Science; Physics GA BJZ02 UT WOS:000267477200007 ER PT S AU Dammann, JF Hull, DM AF Dammann, John F. Hull, David M. BE Woods, AJ Holliman, NS Merritt, JO TI 3-D visualization of electrostatic fields on a helicopter in flight SO STEREOSCOPIC DISPLAYS AND APPLICATIONS XIX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Stereoscopic Displays and Applications XIX CY JAN 28-30, 2008 CL San Jose, CA SP SPIE, IS&T, Soc Imaging Sci & Technol, IMAX, REAL D, Christie Digital Syst, JVC Professional, DepthQ Stereoscop, Kerner Opt LLC, 3D Biz Ex, MTBS3D, Veritas Visus, Stereo World AB Aircraft in flight typically charge via electrostatic processes; this charge is the source of measurable electric fields. Nearby objects may perturb this field, so there is interest in developing electrostatic sensors that can sense nearby objects like power lines by measuring their effects on the field. A major obstacle to developing these sensors is that there are often large variations in the field due to other causes. The problem is particularly difficult for helicopters where the rotating blades cause large periodic variations in field intensity. The Army Research Laboratory (ARL) has developed a model that predicts these self-generated variations so they can be cancelled out and the smaller variations from other objects can be seen. A new code is presented that was developed at ARL for visualization of the complex fields present on helicopters. The fields are different on virtually every part of the aircraft and vary with both the main and tail rotor positions. The code combines a large number of different quasi-static calculations in a single animated display where field strengths are "painted" as textures on the aircraft model. The code allows the user to view the time variations from any viewpoint in stereo. The stereo viewing is very important for clear and easy interpretation of the complex field patterns produced by the models. C1 [Dammann, John F.; Hull, David M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Dammann, JF (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 4 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-6975-5 J9 PROC SPIE PY 2008 VL 6803 AR 68031C DI 10.1117/12.766362 PG 9 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BHR29 UT WOS:000255635100046 ER PT J AU Tinnel, BA Henderson, MA Witt, TC Fakiris, AJ Worth, RM Rosiers, PMD Edmondson, JW Timmerman, RD Lo, SS AF Tinnel, Brent A. Henderson, Mark A. Witt, Thomas C. Fakiris, Achilles J. Worth, Robert M. Rosiers, Paul M. Des Edmondson, James W. Timmerman, Robert D. Lo, Simon S. TI Endocrine Response after Gamma Knife-Based Stereotactic Radiosurgery for Secretory Pituitary Adenoma SO STEREOTACTIC AND FUNCTIONAL NEUROSURGERY LA English DT Article DE Gamma Knife; Stereotactic radiosurgery; Secretory pituitary adenoma; Endocrine response ID TRANSSPHENOIDAL SURGERY; CAVERNOUS SINUS; FOLLOW-UP; EXPERIENCE; PROLACTINOMAS; RADIOTHERAPY; DISEASE; TUMORS AB Purpose: To examine treatment outcomes of Gamma Knife-based stereotactic radiosurgery (GK-based SRS) for secretory pituitary adenomas. Materials and Methods: 25 patients were treated with GK-based SRS for secretory pituitary adenomas with >= 12 months of follow-up. Results: For prolactinomas, 2 of 4 patients (50%) showed normalization of serum prolactin at a mean time of 18 months. One of 4 had a >= 50% decrease but still abnormal prolactin levels. For adrenocorticotrophic hormone-secreting tumors, 6 of 12 patients (50%) showed normalization of their endocrine levels at a median of 10 months. An additional 2 (17%) had a >= 50% decrease. For growth hormone-secreting tumors, 4 of 9 patients (44%) showed normalization of endocrine levels at a median time of 30 months. Two patients (22%) had >= 50% lower but abnormal endocrine levels. Conclusion: GK-based SRS provides a reasonable rate of endocrine normalization of secretory pituitary adenoma. The time to endocrine response is shorter than reported for fractionated external beam radiotherapy. There is a low risk of optic neuropathy. Copyright (C) 2008 S. Karger AG, Basel C1 [Lo, Simon S.] Ohio State Univ, Med Ctr, Dept Radiat Med, Arthur G James Canc Hosp, Columbus, OH 43210 USA. [Tinnel, Brent A.] Walter Reed Army Med Ctr, Dept Radiat Oncol, Washington, DC 20307 USA. [Henderson, Mark A.; Fakiris, Achilles J.] Indiana Univ, Med Ctr, Dept Radiat Oncol, Indianapolis, IN USA. [Witt, Thomas C.; Worth, Robert M.] Indiana Univ, Med Ctr, Dept Neurosurg, Indianapolis, IN USA. [Edmondson, James W.] Indiana Univ, Med Ctr, Div Endocrinol, Dept Med, Indianapolis, IN USA. [Rosiers, Paul M. Des] Faith Hope & Love Canc Ctr, Dept Radiat Oncol, Lafayette, IN USA. [Timmerman, Robert D.] Univ Texas SW Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA. RP Lo, SS (reprint author), Ohio State Univ, Med Ctr, Dept Radiat Med, Arthur G James Canc Hosp, 300 W 10th Ave,Ste 088A, Columbus, OH 43210 USA. EM simon.lo@osumc.edu RI Timmerman, Robert/C-2222-2013 NR 27 TC 17 Z9 20 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1011-6125 J9 STEREOT FUNCT NEUROS JI Stereotact. Funct. Neurosurg. PY 2008 VL 86 IS 5 BP 292 EP 296 DI 10.1159/000151717 PG 5 WC Neurosciences; Neuroimaging; Surgery SC Neurosciences & Neurology; Surgery GA 357VR UT WOS:000259875800004 PM 18758206 ER PT S AU Chang, MH AF Chang, Mou-Hsiung BA Chang, MH BF Chang, MH TI Stochastic Control of Hereditary Systems and Applications Introduction and Summary SO STOCHASTIC CONTROL OF HEREDITARY SYSTEMS AND APPLICATIONS SE Stochastic Modelling and Applied Probability LA English DT Editorial Material; Book Chapter ID JACOBI-BELLMAN EQUATIONS; VISCOSITY SOLUTIONS; TRANSACTION COSTS; DIFFERENTIAL EQUATIONS; VERIFICATION THEOREMS; DIFFUSION-PROCESSES; SECURITIES MARKETS; OPTIMAL INVESTMENT; DELAY EQUATIONS; BANACH-SPACES C1 USA, Res Off, Durham, NC 27703 USA. RP Chang, MH (reprint author), USA, Res Off, 4300 S Miami Blvd, Durham, NC 27703 USA. EM mouhsiung.chang@us.army.mil; mouhsiung.chang@us.army.mil NR 0 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0172-4568 BN 978-0-387-75805-3 J9 STOCH MOD APPL PROBA PY 2008 VL 59 BP 1 EP + D2 10.1007/978-0-387-75816-9 PG 44 WC Operations Research & Management Science; Mathematics, Applied SC Operations Research & Management Science; Mathematics GA BJY48 UT WOS:000267420300001 ER PT J AU Chang, MH Pang, T Pemy, M AF Chang, Mou-Hsiung (Harry) Pang, Tao Pemy, Moustapha TI Optimal control of stochastic functional differential equations with a bounded memory SO STOCHASTICS-AN INTERNATIONAL JOURNAL OF PROBABILITY AND STOCHASTIC PROCESSES LA English DT Article DE Stochastic control; Stochastic functional differential equations; Viscosity solutions; Hamilton-Jacobi-Bellman equation AB This paper treats a finite time horizon optimal control problem in which the controlled state dynamics are governed by a general system of stochastic functional differential equations with a bounded memory. An infinite dimensional Hamilton-Jacobi-Bellman (HJB) equation is derived using a Bellman-type dynamic programming principle. It is shown that the value function is the unique viscosity solution of the HJB equation. C1 [Pang, Tao] N Carolina State Univ, Dept Math, Ctr Res Sci Computat, Raleigh, NC 27695 USA. [Chang, Mou-Hsiung (Harry)] USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. [Pemy, Moustapha] Towson Univ, Dept Math, Towson, MD 21252 USA. RP Pang, T (reprint author), N Carolina State Univ, Dept Math, Ctr Res Sci Computat, Raleigh, NC 27695 USA. EM mouhsiung.chang@us.army.mil; tpang@unity.ncsu.edu; mpemy@towson.edu FU US Army Research Office [W911NF-04-D-0003] FX This research is partially supported by a grant W911NF-04-D-0003 from the US Army Research Office. NR 22 TC 11 Z9 11 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1744-2508 J9 STOCHASTICS JI Stochastics PY 2008 VL 80 IS 1 BP 69 EP 96 DI 10.1080/17442500701605494 PG 28 WC Mathematics, Applied; Statistics & Probability SC Mathematics GA V12VZ UT WOS:000207628000004 ER PT S AU Pfau, D Baker, EL Suarez, D Pincay, JM Madsen, T Ng, KW AF Pfau, D. Baker, E. L. Suarez, D. Pincay, J. M. Madsen, T. Ng, K. W. BE Jones, N Brebbia, CA TI Advances in continuum modelling of urban wall structures impact SO STRUCTURES UNDER SHOCK AND IMPACT X SE WIT Transactions on the Built Environment LA English DT Proceedings Paper CT 10th International Conference on Structures Under Shock and Impact CY MAY, 2008 CL Wessex Inst Technol, Algarve, PORTUGAL SP WIT Transactions Built Environment HO Wessex Inst Technol DE mesh reduction methodologies; high rate continuum modelling; impact physics; high explosives AB Recent advancements of continuum modelling are now allowing significant improvements of urban wall structures impact simulation. Urban wall structural details can now be included in impact modelling that were not previously achievable. These modelling improvements incorporate the inclusion of resolved reinforcement bars in concrete walls, brick and mortar construction details in brick wall construction and resolved cavity and mortar configurations in brick over block wall constructions. These modelling improvements are being achieved not only due to increases in computer hardware speeds and memory, but more so due to a variety of mesh reduction methodologies that have proven to be improved modelling techniques. An adaptive mesh refinement (AMR) technique has been implemented for use in the CTH high rate Eulerian finite difference model. We have applied this AMR to successfully resolve complex material geometries and dominating physical phenomena. In addition, relaxation algorithms have been successfully applied for high rate continuum Arbitrary Lagrangian-Eulerian (ALE) modelling. These relaxation algorithms are now being used in the ALE-3D computer program to provide high resolution simulation of urban wall impacts and penetrations. These new techniques are now allowing the high rate continuum modelling of physical phenomena that was not previously simulated. C1 [Pfau, D.; Baker, E. L.; Suarez, D.; Pincay, J. M.; Madsen, T.; Ng, K. W.] USA, Armanent Res Dev & Engn Ctr, Picatinny Arsenal, NJ USA. RP Pfau, D (reprint author), USA, Armanent Res Dev & Engn Ctr, Picatinny Arsenal, NJ USA. NR 9 TC 0 Z9 0 U1 0 U2 1 PU WIT PRESS/COMPUTATIONAL MECHANICS PUBLICATIONS PI SOUTHAMPTON PA ASHURST LODGE, ASHURST, SOUTHAMPTON SO40 7AA, ENGLAND SN 1746-4498 BN 978-1-84564-107-8 J9 WIT TRANS BUILT ENV PY 2008 VL 98 BP 35 EP 43 DI 10.2495/SU080041 PG 9 WC Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Construction & Building Technology; Engineering; Materials Science GA BHW28 UT WOS:000256999400004 ER PT J AU Ayers, N AF Ayers, Nick TI Ghost Martyrs in Iraq: An assessment of the applicability of rationalist models to explain suicide attacks in Iraq SO STUDIES IN CONFLICT & TERRORISM LA English DT Article ID TERRORISM AB Scholars have developed several rationalist explanations for the use of suicide attacks by terrorist organizations. Using evidence from Palestine, Israel, Lebanon, Sri Lanka, Chechnya, and Turkey, these authors have created plausible and rational models for attacks, which many consider to be irrational. Although the conflict in Iraq has, by most accounts, experienced more suicide bombings than any other struggle, its contemporary nature has made research and analysis on the subject difficult. This article analyzes four of these models and their implications with respect to the events in Iraq. Although the evidence is not conclusive, the data suggests that organizations are not using suicide attacks to (1) gain nationalist objectives, (2) signal strength to a foreign government, or (3)outbid rival organizations, as many scholars suggest. Instead, the evidence suggests that these attacks are used for (1) tactical advantages and (2) to aid the global recruiting effort of Al Qaeda-linked organizations. C1 USA, US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Ayers, N (reprint author), USA, US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. EM nicholas.ayers@us.army.mil NR 37 TC 4 Z9 4 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1057-610X J9 STUD CONFL TERROR JI Stud. Confl. Terror. PY 2008 VL 31 IS 9 BP 856 EP 882 DI 10.1080/10576100802291550 PG 27 WC International Relations; Political Science SC International Relations; Government & Law GA 343ZQ UT WOS:000258895400004 ER PT J AU Ames, SC Rock, E Hurt, RD Patten, CA Croghan, IT Stoner, SM Decker, PA Offord, KP Nelson, M AF Ames, Steven C. Rock, Emily Hurt, Richard D. Patten, Christi A. Croghan, Ivana T. Stoner, Sarah M. Decker, Paul A. Offord, Kenneth P. Nelson, Melissa TI Development and feasibility of a parental support intervention for adolescent smokers SO SUBSTANCE USE & MISUSE LA English DT Article DE tobacco cessation; smoking cessation; adolescent; parent support; social support; support networks; family intervention; change agent ID CIGARETTE-SMOKING; SUBSTANCE USE; FAMILY; PREDICTORS; DEPENDENCE; BEHAVIORS; HEALTH; RISK AB The aim of this investigation was to develop and evaluate the feasibility and acceptability of a parental support intervention. A new measure of perceived parental support for stopping smoking was also developed. The sample included 59 adolescent-parent pairs recruited from a mid-sized Midwestern town during 2000-2003. The mean SD age of the participants (32 males, 27 females) was 16.3 0.9 (range 14-18) years and 86% were Caucasian, 7% American Indian, 5% African American, and 2% Hispanic. Participants were randomized to parental support or minimum behavioral intervention. Severity of nicotine dependence was evaluated using the Fagerstrm Tolerance Questionnaire, and perceived social support was evaluated using the Family Environment Scale and the new measure of perceived parent support for stopping smoking that was developed as part of this investigation. Treatment attendance, adherence, and acceptability were also evaluated. The parental support intervention was feasible but not superior to the minimum behavioral intervention with respect to attendance, retention, or change in support. This study expands on the knowledge of treating adolescent smokers and presents a new assessment measure. The study's limitations are noted. This investigation was funded by NICHHD. C1 [Ames, Steven C.] Mayo Clin, Div Hematol & Oncol, Jacksonville, FL 32224 USA. [Rock, Emily; Patten, Christi A.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA. [Hurt, Richard D.; Croghan, Ivana T.; Nelson, Melissa] Mayo Clin, Nicotine Res Program, Rochester, MN USA. [Stoner, Sarah M.; Decker, Paul A.; Offord, Kenneth P.] Mayo Clin, USA, Div Biostat, Rochester, MN USA. [Ames, Steven C.; Hurt, Richard D.; Patten, Christi A.; Croghan, Ivana T.; Decker, Paul A.] Mayo Clin, USA, Ctr Comprehens Canc, Rochester, MN USA. RP Ames, SC (reprint author), Mayo Clin, Div Hematol & Oncol, 4500 San Pablo Rd, Jacksonville, FL 32224 USA. EM ames.steven@mayo.edu FU NICHD NIH HHS [HD37083] NR 31 TC 2 Z9 2 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1082-6084 J9 SUBST USE MISUSE JI Subst. Use Misuse PY 2008 VL 43 IS 3-4 BP 497 EP 511 DI 10.1080/10826080701208426 PG 15 WC Substance Abuse; Psychiatry; Psychology SC Substance Abuse; Psychiatry; Psychology GA 279IZ UT WOS:000254350200017 PM 18365946 ER PT J AU Buckley, J AF Buckley, John TI On war: Lessons learned SO SURVIVAL LA English DT Letter C1 USA, Off Chief Staff, Headquarters Staff Grp, Execut Off, Washington, DC 20310 USA. RP Buckley, J (reprint author), USA, Off Chief Staff, Headquarters Staff Grp, Execut Off, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0039-6338 J9 SURVIVAL JI Survival PY 2008 VL 50 IS 3 BP 241 EP 243 PG 3 WC International Relations; Political Science SC International Relations; Government & Law GA 317OG UT WOS:000257028900031 ER PT J AU Vane, MA AF Vane, Michael A. TI On war: Lessons learned SO SURVIVAL LA English DT Letter C1 USA, Training & Doctrine Command, Army Capabil & Integrat Ctr, Ft Monroe, VA USA. RP Vane, MA (reprint author), USA, Training & Doctrine Command, Army Capabil & Integrat Ctr, Ft Monroe, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0039-6338 J9 SURVIVAL JI Survival PY 2008 VL 50 IS 3 BP 245 EP 247 PG 3 WC International Relations; Political Science SC International Relations; Government & Law GA 317OG UT WOS:000257028900033 ER PT J AU Tramel, P AF Tramel, Peter TI Haack's foundherentism is a foundationalism SO SYNTHESE LA English DT Article DE Haack; Susan; BonJour; Laurence; foundationalism; foundherentism; coherentism; epistemic justification ID JUSTIFICATION; EXPERIENCE AB Susan Haack has always maintained that her unquestionably important foundherentist theory of epistemic justification is not a foundationalism. In a 1997 Synthese exchange, Laurence BonJour questioned her right to this claim, and she dug in and defended it. What was at stake is of timeless importance to epistemology: it goes directly to the question, "What is foundationalism?" I inquire with greater care than either Haack or BonJour took in 1997, and I find decisively in favor of the view that foundherentism is a foundationalism. In the process, I explore the outer limits of foundationalism: I examine just how far a foundationalism can go in allowing the relevance of coherence to epistemic justification. C1 US Mil Acad, Dept Engn & Philosophy, West Point, NY 10996 USA. RP Tramel, P (reprint author), US Mil Acad, Dept Engn & Philosophy, 607 Cullum Rd,West Point, West Point, NY 10996 USA. EM peter.tramel@usma.edu NR 7 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0039-7857 J9 SYNTHESE JI Synthese PD JAN PY 2008 VL 160 IS 2 BP 215 EP 228 DI 10.1007/s11229-006-9108-y PG 14 WC History & Philosophy Of Science; Philosophy SC History & Philosophy of Science; Philosophy GA 248QR UT WOS:000252169900005 ER PT J AU Lou, JD Huang, LH Marrogi, AJ Li, F Li, L Gao, CL AF Lou, Ji-Dong Huang, Li-Hong Marrogi, Aizen J. Li, Feng Li, Li Gao, Chun-Ling TI Selective oxidation of alcohols with a new reagent: Iron(III) nitrate supported on aluminum silicate SO SYNTHETIC COMMUNICATIONS LA English DT Article DE alcohol; aluminum silicate; iron (III); nitrate nonahydrate; oxidation AB A selective and effective oxidation of alcohols, except aliphatic alcohols, such as 1-hexanol or 1-octyl alcohol, to the corresponding aldehydes and ketones using a new reagent, iron(III) nitrate supported on aluminum silicate, under heterogeneous conditions with reflux with 85 - 98% yield is described. C1 [Gao, Chun-Ling] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. [Lou, Ji-Dong; Huang, Li-Hong] China Inst Metrol, Coll Life Sci, Hangzhou, Zhejiang, Peoples R China. [Marrogi, Aizen J.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Marrogi, Aizen J.] Walter Reed Army Med Ctr, Area Lab Med, Washington, DC 20307 USA. [Li, Feng; Li, Li] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia. RP Gao, CL (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. EM gao-cl@sohu.com RI Li, Feng/H-4099-2011 NR 8 TC 2 Z9 2 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0039-7911 J9 SYNTHETIC COMMUN JI Synth. Commun. PY 2008 VL 38 IS 3 BP 428 EP 433 DI 10.1080/00397910701771173 PG 6 WC Chemistry, Organic SC Chemistry GA 260WX UT WOS:000253042200014 ER PT J AU Duddu, R Dave, PR Damavarapu, R Surapaneni, R Gilardi, R Parrish, D AF Duddu, Raja Dave, Paritosh R. Damavarapu, Reddy Surapaneni, Rao Gilardi, Richard Parrish, Damon TI Synthesis of azido heterocycles SO SYNTHETIC COMMUNICATIONS LA English DT Article DE azido compounds; hexaazaisowurtzitane; nitro compounds; tetrazine; triazine ID 1,3,3-TRINITROAZETIDINE AB Syntheses of azido derivatives of hexaazaisowurtzitane, triazine, and tetrazine heterocyclic compounds are described. C1 [Duddu, Raja; Dave, Paritosh R.] SAIC, ARDEC, Picatinny Arsenal, NJ USA. [Damavarapu, Reddy; Surapaneni, Rao] US Army ARDEC, Picatinny Arsenal, NJ USA. [Gilardi, Richard; Parrish, Damon] Naval Res Lab, Lab Struct Matter, Washington, DC USA. RP Duddu, R (reprint author), SAIC, US Army ARDEC, Bldg 3028, Picatinny Arsenal, NJ 07806 USA. EM rduddu@pica.army.mil NR 24 TC 14 Z9 14 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0039-7911 J9 SYNTHETIC COMMUN JI Synth. Commun. PY 2008 VL 38 IS 5 BP 767 EP 774 DI 10.1080/00397910701820459 PG 8 WC Chemistry, Organic SC Chemistry GA 265BT UT WOS:000253334800012 ER PT S AU Buford, JA Barnett, TC Vatz, BW Williams, MJ Van Bebber, J Burson, C AF Buford, James A., Jr. Barnett, Thomas C., Jr. Vatz, Bernard W., II Williams, M. Joshua Van Bebber, James Burson, Cliff BE Murrer, RL TI Integrated defense system framework and high fidelity hardware-in-the-loop sensor stimulators SO TECHNOLOGIES FOR SYNTHETIC ENVIRONMENTS: HARDWARE-IN-THE-LOOP TESTING XIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Technologies for Synthetic Environments - Hardware-in-the-Loop Testing XIII CY MAR 17-18, 2008 CL Orlando, FL SP SPIE AB The Strategic Defense Center of the U.S. Army Aviation and Missile Research, Development and Engineering Center (AMRDEC), System Simulation and Development Directorate (SS&DD) provides modeling and simulation (M&S) tools, providing medium and hi-fi sensor stimulation, and test control frameworks to evaluate performance of integrated defense systems. These systems include hardware and software representations provided by and operated by Service Program Offices or their representatives. The representations are geographically distributed, but linked together to provide a dynamic, real-time, interactive test environment that is centrally controlled and synchronized through Global Positioning System (GPS) sources. The distributed nodes and the central control facility communicate through the Single Stimulation Framework (SSF). Operation of the SSF provides characterization and assessment of the integrated defense systems. This paper will summarize the concept, features, and functions of the SSF. The complex communications will be discussed, as well as the philosophy of stimulating the participating system components externally with consistent scenarios and truth state data that will bypass the simulation of these events by the individual participants. C1 [Buford, James A., Jr.; Barnett, Thomas C., Jr.; Vatz, Bernard W., II; Williams, M. Joshua; Van Bebber, James] USA, Army Aviat & Missile Res, Ctr Dev & Engn, Executing Agent Missile Def Agcy Directorate Engn, Redstone Arsenal, AL 35898 USA. RP Buford, JA (reprint author), USA, Army Aviat & Missile Res, Ctr Dev & Engn, Executing Agent Missile Def Agcy Directorate Engn, Redstone Arsenal, AL 35898 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7133-8 J9 PROC SPIE PY 2008 VL 6942 AR 694205 DI 10.1117/12.782450 PG 7 WC Computer Science, Hardware & Architecture; Optics SC Computer Science; Optics GA BHW94 UT WOS:000257113800004 ER PT S AU Das, NC Kiamilev, F Prineas, JP Olesberg, JT Koerperick, EJ Murray, LM Boggess, TF AF Das, Naresh C. Kiamilev, Fouad Prineas, J. P. Olesberg, J. T. Koerperick, E. J. Murray, L. M. Boggess, T. F. BE Murrer, RL TI Performance of 64x64 MWIR super lattice light-emitting diode (SLED) array for IR scene generation SO TECHNOLOGIES FOR SYNTHETIC ENVIRONMENTS: HARDWARE-IN-THE-LOOP TESTING XIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Technologies for Synthetic Environments - Hardware-in-the-Loop Testing XIII CY MAR 17-18, 2008 CL Orlando, FL SP SPIE DE MWIR; LED array; CMOS driver; IR scene; apparent temperature AB We designed and fabricated 64x64 supper lattice light emitting diode (SLED) array with peak emission wavelength of 3.8 micron. The light emission is observed from the bottom side of the device through the substrate. The CMOS driver circuit is fabricated in the 130 nm IBM 8HP SiGe process. The unit cells were designed to source up to 100mA to the LED. These unit cells can be individually addressable, and have analog drive and memory that can operate at a 1 kHz array refresh rate. We use supper lattice epitaxial active region LED structures grown on n-type GaSb substrates. After initial mesa etching and contact metal deposition, the LED array is flip chip mounted on the LCC package. The light emission is observed from the LED array by InSb focal plane MWIR camera and the apparent black body temperature is measured. C1 [Das, Naresh C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Das, NC (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM ndas@arl.army.mil NR 6 TC 0 Z9 0 U1 2 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7133-8 J9 PROC SPIE PY 2008 VL 6942 AR 69420I DI 10.1117/12.782652 PG 9 WC Computer Science, Hardware & Architecture; Optics SC Computer Science; Optics GA BHW94 UT WOS:000257113800013 ER PT S AU Kim, HJ Cornell, MC Naumann, CB Bowden, MH AF Kim, Hajin J. Cornell, Michael C. Naumann, Charles B. Bowden, Mark H. BE Murrer, RL TI High accuracy LADAR scene projector calibration sensor development SO TECHNOLOGIES FOR SYNTHETIC ENVIRONMENTS: HARDWARE-IN-THE-LOOP TESTING XIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Technologies for Synthetic Environments - Hardware-in-the-Loop Testing XIII CY MAR 17-18, 2008 CL Orlando, FL SP SPIE DE LADAR; hardware-in-the-loop; sensor; projector; range ID HWIL SYNTHETIC ENVIRONMENT AB A sensor system for the characterization of infrared laser radar scene projectors has been developed. Available sensor systems do not provide sufficient range resolution to evaluate the high precision LADAR projector systems developed by the U.S. Army Research, Development and Engineering Command (RDECOM) Aviation and Missile Research, Development and Engineering Center (AMRDEC). With timing precision capability to a fraction of a nanosecond, it can confirm the accuracy of simulated return pulses from a nominal range of up to 6.5 km to a resolution of 4cm. Increased range can be achieved through firmware reconfiguration. Two independent amplitude triggers measure both rise and fall time providing a judgment of pulse shape and allowing estimation of the contained energy. Each return channel can measure up to 32 returns per trigger characterizing each return pulse independently. Currently efforts include extending the capability to 8 channels. This paper outlines the development, testing, capabilities and limitations of this new sensor system. C1 [Kim, Hajin J.] USA, RDECOM, Aviat & Missile RDEC, Redstone Arsenal, AL 35898 USA. RP Kim, HJ (reprint author), USA, RDECOM, Aviat & Missile RDEC, AMSRD AMR SS HW Bldg 5400, Redstone Arsenal, AL 35898 USA. EM hajin.j.kim@us.army.mil NR 3 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7133-8 J9 PROC SPIE PY 2008 VL 6942 AR 694206 DI 10.1117/12.778352 PG 12 WC Computer Science, Hardware & Architecture; Optics SC Computer Science; Optics GA BHW94 UT WOS:000257113800005 ER PT S AU O'Brien, SG Tofsted, DH AF O'Brien, Sean G. Tofsted, David H. BE Jensen, JO Cui, HL Woolard, DL Hwu, RJ TI Terahertz target illumination fluctuation estimates derived from field measurements of atmospheric water vapor SO TERAHERTZ FOR MILITARY AND SECURITY APPLICATIONS IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Terahertz for Military and Security Applications VI CY MAR 18-19, 2008 CL Orlando, FL SP SPIE AB Many terahertz imaging systems under development will be employed in outdoor environments, where spatial and temporal fluctuations of atmospheric absorbing species can affect image quality. Absorption across most of the terahertz band is dominated by water vapor. Active systems that illuminate targets with scanned ("flying spot") or floodlight terahertz; sources will experience some spatial and temporal noise modulation of target plane irradiance due to path-integrated inhomogeneities in the turbulent water vapor density field. We have analyzed data collected during field measurement campaigns conducted at the White Sands Missile Range during the spring and summer of 2007 for spectral characteristics and diurnal variations of water vapor fluctuations under dry to moderately humid synoptic conditions. The results of these analyses were then used to model the statistics of irradiance fluctuations that might be observed in the target plane of a THz imager under varying propagation conditions. The measurements acquired can also be compared with a statistical model of path-integrated absorptance considering either the evolution of the absorption with time or the effects of decorrelation in absorber for two angularly separated lines-of-sight. C1 [O'Brien, Sean G.; Tofsted, David H.] USA, Res Lab, Computat & Informat Sci Directorate, White Sands Missile Range, NM 88002 USA. RP O'Brien, SG (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, White Sands Missile Range, NM 88002 USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7140-6 J9 PROC SPIE PY 2008 VL 6949 AR 694906 DI 10.1117/12.783073 PG 11 WC Optics; Physics, Applied; Spectroscopy SC Optics; Physics; Spectroscopy GA BHX01 UT WOS:000257137300005 ER PT J AU Jensen, GM Ashvar, CS Bunte, SW Barzak, CD Bunch, TH Fahrner, RL Hu, N Kennavane, J Pham, H Skenes, C Yang, S AF Jensen, G. M. Ashvar, C. S. Bunte, S. W. Barzak, C. D. Bunch, T. H. Fahrner, R. L. Hu, N. Kennavane, J. Pham, H. Skenes, C. Yang, S. TI A liposomal dispersion formulation of propofol: formulation, pharmacokinetics, stability, and identification of an oxidative degradant SO THEORETICAL CHEMISTRY ACCOUNTS LA English DT Article ID CIRCULAR-DICHROISM SPECTRA; VIBRATIONAL ABSORPTION AB Propofol is a common and highly effective anesthetic. Commercially available formulations of propofol, which is only sparingly soluble in aqueous systems, utilize emulsion technology. A liposome based dispersion formulation of propofol has been produced which exhibits good long term colloidal and chemical stability and pharmacokinetcs indistinguishable from the emulsion systems. Inclusion of 0.01% ascorbic acid in the final formulation arrests the growth of an oxidative degradant of propofol both during production and on stability. This degradant is identified as being the dimer 4,4'-dihydroxy-3,3', 5,5'-tetraisopropylbiphenyl by mass spectroscopy and comparison of the infrared spectrum of the purified degradant to predicted spectra generated using density functional theory. C1 [Jensen, G. M.; Ashvar, C. S.; Barzak, C. D.; Bunch, T. H.; Fahrner, R. L.; Hu, N.; Kennavane, J.; Pham, H.; Skenes, C.; Yang, S.] Gilead Sci Inc, San Dimas, CA 91773 USA. [Bunte, S. W.] USA, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Jensen, GM (reprint author), Gilead Sci Inc, 650 Cliffside Dr, San Dimas, CA 91773 USA. EM gjensen@gilead.com NR 11 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1432-881X J9 THEOR CHEM ACC JI Theor. Chem. Acc. PD JAN PY 2008 VL 119 IS 1-3 BP 291 EP 296 DI 10.1007/s00214-007-0288-4 PG 6 WC Chemistry, Physical SC Chemistry GA 244NF UT WOS:000251871900023 ER PT S AU Goldberg, E AF Goldberg, Eugene BE Buning, HK Zhao, XH TI A decision-making procedure for resolution-based SAT-solvers SO THEORY AND APPLICATIONS OF SATISFIABILITY TESTING - SAT 2008, PROCEEDINGS SE LECTURE NOTES IN COMPUTER SCIENCE LA English DT Proceedings Paper CT 11th International Conference on Theory and Applications of Satisfiability Testing CY MAY 12-15, 2008 CL Guangzhou, PEOPLES R CHINA SP Natl Nat Sci Fdn China, Sun Yat Sen Univ, Guangzhou, Sun Yat Sen Univ, Inst Log & Cognit, Univ Paderborn, Dept Comp Sci, Hexin Technol, Intel Design Technologies & Solut, KC Wong Educ Fdn, Light Engn, Microsoft Res, NEC Labs America, Potevio ID SATISFIABILITY; ASSIGNMENTS AB We describe a new decision-making procedure for resolution-based SAT-solvers called Decision Making with a Reference Point (DMRP). In DMRP, a complete assignment called a reference point is maintained. DMRP is aimed at finding a change of the reference point under which the number of clauses falsified by the modified point is smaller than for the original one. DMRP makes it possible for a DPLL-like algorithm to perform a "local search strategy". We describe a SAT-algorithm with conflict clause learning that uses DMRP. Experimental results show that even a straightforward and unoptimized implementation of this algorithm is competitive with SAT-solvers like BerkMin and Minisat on practical formulas. Interestingly, DMRP is beneficial not only for satisfiable but also for unsatisfiable formulas. C1 USA, Cadence Res Labs, Berkeley, CA 94704 USA. RP Goldberg, E (reprint author), USA, Cadence Res Labs, 2150 Shattuck Ave,10th Floor, Berkeley, CA 94704 USA. NR 24 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-540-79718-0 J9 LECT NOTES COMPUT SC PY 2008 VL 4996 BP 119 EP 132 PG 14 WC Computer Science, Theory & Methods SC Computer Science GA BHS18 UT WOS:000255924800011 ER PT S AU Taylor, PJ Morgan, B Dhar, NK Chen, Y AF Taylor, Patrick J. Morgan, Brian Dhar, Nibir K. Chen, Y. BE Hogan, TP Yang, J Funahashi, R Tritt, TM TI New approach for the synthesis of IV-VI thermoelectric thin film materials and devices on Si: (211) PbSnSeTe/ZnTe/Si heterostructures SO THERMOELECTRIC POWER GENERATION SE MATERIALS RESEARCH SOCIETY SYMPOSIUM PROCEEDINGS LA English DT Proceedings Paper CT 8th Symposium on Themoelectric Power Generation held 2007 MRS Fall Meeting CY NOV 26-29, 2007 CL Boston, MA SP Mat Res Soc ID MOLECULAR-BEAM EPITAXY; INFRARED PHOTODIODES; GROWTH; LAYERS; REDUCTION; TELLURIDE; SI(111); PBTE AB Low-dimensional thin-film thermoelectric materials including superlattices and quantum-dot heterostructures have shown significant potential for improving the thermoelectric properties. Highly structured thin film materials such as these would be useful for integrated microdevices such as power MEMS and thermally triggered MEMS actuators. For reasons including scalability and ease-of-integration, silicon is the choice material for the substrate, however there is a lattice and a thermal-expansion mismatch. In this work, a new approach for the synthesis of integrated PbSnSeTe based thermoelectric thin Film materials on silicon is demonstrated by employing an epitaxial buffer layer of H-VI compound telluride materials (e.g., ZnTe, CdTe) to help bridge the lattice and thermal expansion mismatches with silicon. This multilayer can be used for subsequent growth of thick films having low-dimensionality structures. We report the initial results from studying the structural and thermoelectric properties of simple solid-solution alloy PbSnSeTe thin films on ZnTe/Si heterostructures. Data from transmission electron microscopy and in-situ electron diffraction will be presented that shows that despite the large lattice mismatch with silicon and the three different crystal structures, unusually high structural quality PbSnSeTe has been obtained by matching the (211) lattice symmetry and the lattice spacing along the [110] directions of the ZnTe and PbSnSeTe. The structural quality of the PbSnSeTe was studied by measuring the dislocation density through etch-pit counting and x-ray diffraction. Results presented will show that a dislocation density as low as 1.2 x 10(6)/cm(2) can be achieved by strategic lattice-matching between the buffer and thermoelectric layers. Electrical resistivity, doping density, and Seebeck coefficient values for solid-solution alloys without low-dimensional structuring will be shown to approach those of high-performance bulk. C1 [Taylor, Patrick J.] USA, Res Lab, AMSRD ARL SE EI Taylor, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Taylor, PJ (reprint author), USA, Res Lab, AMSRD ARL SE EI Taylor, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 19 TC 0 Z9 0 U1 0 U2 2 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DRIVE, WARRENDALE, PA 15088-7563 USA SN 0272-9172 BN 978-1-55899-987-9 J9 MATER RES SOC SYMP P PY 2008 VL 1044 BP 381 EP 388 PG 8 WC Energy & Fuels; Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Energy & Fuels; Engineering; Science & Technology - Other Topics; Materials Science GA BIC65 UT WOS:000258399500056 ER PT S AU Carson, J Corner, BD Crockett, E Li, P Paquette, S AF Carson, Jeremy Corner, Brian D. Crockett, Eric Li, Peng Paquette, Steven BE Corner, BD Mochimaru, M Sitnik, R TI Comparison of Cyberware PX and PS 3D human head scanners SO THREE-DIMENSIONAL IMAGE CAPTURE AND APPLICATIONS 2008 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Three-Dimensional Image Capture and Applications 2008 CY JAN 28-29, 2008 CL San Jose, CA SP SPIE, IS&T, Soc Imaging Sci & Technol DE laser scanning; head anthropometry AB A common limitation of laser line three-Dimensional (3D) scanners is the inability to scan objects with surfaces that are either parallel to the laser line or that self-occlude. Filling in missing areas adds some unwanted inaccuracy to the 3D model. Capturing the human head with a Cyberware PS Head Scanner is an example of obtaining a model where the incomplete areas are difficult to fill accurately. The PS scanner uses a single vertical laser line to illuminate the head and is unable to capture data at top of the head, where the line of sight is tangent to the surface, and under the chin, an area occluded by the chin when the subject looks straight forward. The Cyberware PX Scanner was developed to obtain this missing 3D head data. The PX scanner uses two cameras offset at different angles to provide a more detailed head scan that: captures surfaces missed by the PS scanner. The PX scanner cameras also use new technology to obtain color maps that are of higher resolution than the PS Scanner. The two scanners were compared in terms of amount of surface captured (surface area and volume) and the quality of head measurements when compared to direct measurements obtained through standard anthropometry methods. Relative to the PS scanner, the PX head scans were more complete and provided the full set of head measurements, but actual measurement values, when available from both scanners, were about the same. C1 [Carson, Jeremy; Corner, Brian D.; Paquette, Steven] USA, Natick Soldier, RDEC, Natick, MA 01760 USA. RP Carson, J (reprint author), USA, Natick Soldier, RDEC, Natick, MA 01760 USA. EM jeremy.carson@us.army.mil NR 4 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-6977-9 J9 PROC SPIE PY 2008 VL 6805 AR 68050N DI 10.1117/12.761700 PG 8 WC Computer Science, Software Engineering; Optics SC Computer Science; Optics GA BHR56 UT WOS:000255679800020 ER PT B AU Adams, J Duz, V Moxson, V AF Adams, Jane Duz, Volodymyr Moxson, Vladimir GP TMS TI Powder metallurgy processes for producing titanium alloy products from hydrogenated titanium powder SO TMS 2008 ANNUAL MEETING SUPPLEMENTAL PROCEEDINGS, VOL 1: MATERIALS PROCESSING AND PROPERTIES LA English DT Proceedings Paper CT 137th Annual Meeting and Exhibition of the Minerals-Metals-and-Materials-Society CY MAR 09-13, 2008 CL New Orleans, LA DE hydrogenated titanium powder; TiH(2); direct powder rolling; Ti-6Al-4V ID COST AB Titanium alloys exhibit attractive mechanical properties, good corrosion resistance and low density, but they are expensive. This paper describes use of direct powder rolling (DPR) processes to produce titanium and titanium alloy flat products (plates, sheets, foils) from hydrogenated titanium powder. A blended elemental (BE) approach is used in this study in which hydrogenated titanium powder produced by a modified Kroll process is alloyed with a master alloy to achieve the required chemistry. Direct roll-compacting to form flat products of near final thickness and subsequent vacuum sintering produces near full density titanium alloys with optimized microstructures and properties equivalent to those of the ingot metallurgy. This article reviews the general DPR process, microstructures, properties and ability to produce titanium alloy flat product in a cost-effective manner. Heat treatments performed on sintered alloys demonstrated that it is possible to achieve refined microstructures with resulting improved combination of mechanical properties. C1 [Adams, Jane] USA, Weapons & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Adams, J (reprint author), USA, Weapons & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 22 TC 0 Z9 0 U1 2 U2 3 PU MINERALS, METALS & MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086-7514 USA BN 978-0-87339-716-2 PY 2008 BP 363 EP 367 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA BHQ98 UT WOS:000255581900051 ER PT B AU Sano, T Catalano, J Casem, D Dandekar, D AF Sano, Tomoko Catalano, James Casem, Daniel Dandekar, Dattatraya GP TMS TI Microstructural and mechanical behavior characterization of ultrasonically consolidated titanium-aluminum laminates SO TMS 2008 ANNUAL MEETING SUPPLEMENTAL PROCEEDINGS, VOL 1: MATERIALS PROCESSING AND PROPERTIES LA English DT Proceedings Paper CT 137th Annual Meeting and Exhibition of the Minerals-Metals-and-Materials-Society CY MAR 09-13, 2008 CL New Orleans, LA DE titanium-aluminum laminates; ultrasonic consolidation; characterization ID COMPOSITES AB Multilayered hybrid metal laminates have been studied for structural applications due to their potential for higher strength, toughness, and stiffness. The goal of this study was to modify the microstructure and mechanical properties of commercial purity titanium (CP-Ti) and 1100 aluminum (A]) laminates for potential applications in mine blast mitigation. Alternating layers of 50 mu m thick CP-Ti and Al layers were ultrasonically consolidated. To provide high hardness and stiffness, the consolidated laminates were heat-treated in a variety of conditions to form intermetallic titanium aluminide (TiAl(3)) layers. The resulting CP-Ti/TiAl(3)/Al laminates were characterized by scanning electron microscopy. Plate impact testing, an instrumented laboratory scale test to characterize the dynamic spall behavior of the material, was conducted on select laminates. Based on these results, the CP-Ti/TiAl(3)/Al laminate had a higher spall strength compared to the Cp-Ti/Al laminate. C1 [Sano, Tomoko; Catalano, James] USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Sano, T (reprint author), USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. NR 7 TC 0 Z9 1 U1 0 U2 3 PU MINERALS, METALS & MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086-7514 USA BN 978-0-87339-716-2 PY 2008 BP 417 EP 422 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA BHQ98 UT WOS:000255581900059 ER PT J AU Reddy, G Allen, NA Major, MA AF Reddy, Gunda Allen, Nicole A. Major, Michael A. TI Absorption of (14)C-Cyclotrimethylenetrinitramine (RDX) from soils through excised human skin SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article; Proceedings Paper CT 42nd Annual Meeting of the Society-of-Toxicology CY MAR 09-13, 2003 CL SALT LAKE CITY, UT SP Soc Toxicol DE absorption; bioavailability; dermal; human; RDX; skin; in vitro; soils ID INVITRO PERCUTANEOUS-ABSORPTION; ANIMAL-MODELS; IN-VITRO; BIOAVAILABILITY; BENZOPYRENE; RAT AB Cyclotrimethylenetrinitramine (RDX), a compound used widely in bursting-type munitions, is a concern for the U.S. Department of Defense because it has been detected in soil and groundwater at military installations. Dermal absorption of (14)C-RDX from acetone solutions and from two different soils was studied using excised human skin (from surgery) in flow-through diffusion cells. RDX in acetone (10 mu L) or in soils (10 mg) was applied to the epidermal surface of the skin (0.64 cm(2)) and allowed to transverse the skin and become dissolved in a reservoir of receptor fluid that was maintained in contact with the dermal surface. The reservoir was of the flow-through type and receptor fluid was pumped at a rate of 1.5 mL/h. Receptor fluid was collected every 6 h for 24 h. Because the bioavailability of a chemical from soils depends on soil composition, dermal absorption of 14C-RDX from both a low-carbon (1.9%) and a high-carbon (9.5%) soil was assessed. At the conclusion of the experiment, the RDX remaining on the skin was washed with soap and water using cotton swabs, and the radioactivity present in washings was determined. The stratum corneum was removed from the deeper epidermis and radioactivity found in that layer was not considered in calculations of dermal absorption. The dermal absorption of RDX was relatively low. Only about 5.7 +/- 1.9% of the RDX that had been applied in acetone was found in the skin (epidermis and dermis) (3.2 +/- 1.9) and receptor fluid (2.5 +/- 1.8) combined (over the full 24-h duration of the study). The levels of RDX found in the skin layers were stratum corneum 2.1%, epidermis 0.83%, and dermis 0.45%. The total recovery of applied dose (receptor fluid, skin, and washings) was about 80%. The extent of RDX absorption from soil was even lower than from acetone. Approximately 2.6 +/- 1.1% of the RDX applied in the low-carbon soil and 1.4 +/- 0.41% applied in the high-carbon soil was found in receptor fluid and skin in 24 h. The total recovery of the applied dose (receptor fluid, skin, and washings) was about 87% for the low-carbon soil and 94% for the high-carbon soil. Thus, the dermal absorption of RDX from soils was reduced considerably when compared with absorption from acetone and absorption was lower in the high-carbon soil than in the low-carbon soil. C1 [Reddy, Gunda; Allen, Nicole A.; Major, Michael A.] USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Hlth Effects Res Program, Aberdeen Proving Ground, MD 21010 USA. RP Reddy, G (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Hlth Effects Res Program, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM gunda.reddy@us.army.mil NR 23 TC 1 Z9 1 U1 0 U2 3 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6516 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PY 2008 VL 18 IS 7 BP 575 EP 579 DI 10.1080/15376510701703466 PG 5 WC Toxicology SC Toxicology GA 346YJ UT WOS:000259105200004 PM 20020856 ER PT J AU Shen, Q Russell, K Sodhi, RS He, Y AF Shen, Qiong Russell, Kevin Sodhi, Raj S. He, Yong TI SPHERICAL FOUR-BAR MOTION GENERATION WITH A PRESCRIBED RIGID-BODY LOAD SO TRANSACTIONS OF THE CANADIAN SOCIETY FOR MECHANICAL ENGINEERING LA English DT Article ID PLANAR; DESIGN AB In motion generation, the objective is to calculate the mechanism parameters required to achieve or approximate a set of prescribed rigid-body positions. This work introduces a new design constraint that considers driving link static torque for a given rigid-body load. By incorporating this new constraint into a conventional spherical four-bar motion generation model [1], spherical four-bar mechanisms are synthesized to achieve-not only prescribed rigid-body positions-but also satisfy a maximum driver static torque for a given rigid-body load. C1 [Shen, Qiong; Sodhi, Raj S.] New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. [Russell, Kevin] US Army Res, Ctr Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [He, Yong] Donghua Univ, Coll Mech Engn, Shanghai 20051, Peoples R China. RP Shen, Q (reprint author), New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. EM kevin.russell1@us.army.mil RI Shen, Qiong/N-4015-2013 NR 14 TC 5 Z9 5 U1 0 U2 0 PU CSME TRANS. PI MONTREAL PA C/O P J ZSOMBOR-MURRAY, MC GILL UNIV, RM 454 THOMAS WORKMAN ENG BLDG 817 SHERBROOKE ST W, MONTREAL, PQ H3A 2K6, CANADA SN 0315-8977 J9 T CAN SOC MECH ENG JI Trans. Can. Soc. Mech. Eng. PY 2008 VL 32 IS 3-4 BP 401 EP 410 PG 10 WC Engineering, Mechanical SC Engineering GA 454OH UT WOS:000266691500006 ER PT J AU Shen, Q Lee, WT Russell, K Sodhi, RS AF Shen, Qiong Lee, Wen-Tzong Russell, Kevin Sodhi, Raj S. TI ON MOTION GENERATION OF WATT I MECHANISMS FOR MECHANICAL FINGER DESIGN SO TRANSACTIONS OF THE CANADIAN SOCIETY FOR MECHANICAL ENGINEERING LA English DT Article ID 6-LINK MECHANISMS; LINKAGES AB This work formulates and demonstrates a motion generation method for the synthesis of a particular type of planar six-bar mechanism-the Watt I mechanism. The Watt. I mechanism is essentially a "stacked" four-bar mechanism (having two closed loops and a single degree of freedom). Extending the planar motion generation method of Suh and Radcliffe [11] to incorporate relative motion between moving pivots, Watt I mechanisms are synthesized to simultaneously approximate two groups of prescribed rigid-body poses for simultaneous dual motion generation capability. The example included demonstrates the synthesis of a finger mechanism to achieve a prescribed grasping pose sequence. C1 [Shen, Qiong; Sodhi, Raj S.] New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. [Lee, Wen-Tzong] Leader Univ, Dept Informat Management, Tainan 70970, Taiwan. [Russell, Kevin] US Army Res, Ctr Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. RP Shen, Q (reprint author), New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. EM kevin.russell1@us.army.mil NR 17 TC 3 Z9 3 U1 0 U2 1 PU CSME TRANS. PI MONTREAL PA C/O P J ZSOMBOR-MURRAY, MC GILL UNIV, RM 454 THOMAS WORKMAN ENG BLDG 817 SHERBROOKE ST W, MONTREAL, PQ H3A 2K6, CANADA SN 0315-8977 J9 T CAN SOC MECH ENG JI Trans. Can. Soc. Mech. Eng. PY 2008 VL 32 IS 3-4 BP 411 EP 421 PG 11 WC Engineering, Mechanical SC Engineering GA 454OH UT WOS:000266691500007 ER PT J AU Newman, JK White, DJ AF Newman, J. Kent White, David J. TI Rapid Assessment of Cement and Fiber-Stabilized Soil Using Roller-Integrated Compaction Monitoring SO TRANSPORTATION RESEARCH RECORD LA English DT Article AB Test sections of high-early strength (Type III) portland cement and polypropylene monofilament fibers were constructed at the Bradshaw Field Training Area in the Northern Territory (NT), Australia as part of a Joint Rapid Airfield Construction (JRAC) project. Aprons, taxiways, and a helipad were stabilized using these materials in combination with screened native soil. The purpose of the test sections was to (a) evaluate the resulting properties for different stabilization dosage rates; (b) develop construction methods, criteria (including limits), and quality control guidelines; and (c) provide a hands-on training opportunity for the joint United States and Australia military construction team. Testing and monitoring consisted of roller-integrated compaction monitoring (global position systems monitoring pass coverages and compaction machine values) and in situ testing, which included dynamic cone penetration tests, Clegg impact tests, and light-weight deflectometer tests. After the test sections, construction of the helipad helped refine the construction methods and quality control testing for the selected stabilization dosage rates and machine speed. Lessons learned on the helipad were applied to the subsequent aircraft parking aprons and taxiways. Recommendations were developed for rapid stabilization construction procedures and quality control testing using Clegg impact values and light-weight deflectometer for cement-fiber stabilized soils, and the application of roller-integrated compaction technology was demonstrated to document compaction effort and uniformity. C1 [Newman, J. Kent] USA, Engineer Res & Dev, CEERD GM A, Vicksburg, MS 39180 USA. [White, David J.] Iowa State Univ, Dept Civil Construct & Environm Engn, Ames, IA 50011 USA. RP Newman, JK (reprint author), USA, Engineer Res & Dev, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM john.k.newman@erdc.usace.army.mil NR 9 TC 0 Z9 0 U1 1 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSP RES RECORD JI Transp. Res. Record PY 2008 IS 2059 BP 95 EP 102 DI 10.3141/2059-11 PG 8 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 382DK UT WOS:000261585000011 ER PT J AU Zaretsky, EV Lewicki, DG Savage, M Vlcek, BL AF Zaretsky, Erwin V. Lewicki, David G. Savage, Michael Vlcek, Brian L. TI Determination of turboprop reduction gearbox system fatigue life and reliability SO TRIBOLOGY & LUBRICATION TECHNOLOGY LA English DT Article DE gearbox life prediction; gearing; rolling-element bearings; Monte-Carlo analysis; probabilistic life analysis; weibull analysis ID SPUR AB Two computational models to determine the fatigue life and reliability of a commercial turboprop gearbox are compared with each other and with field data. These models are (1.) Monte Carlo simulation of randomly selected lives of individual bearings and gears comprising the system and (2.) two-parameter Weibull distribution function for bearings and gears comprising the system using strict-series system reliability to combine the calculated individual component lives in the gearbox. The Monte Carlo simulation included the virtual testing of 744,450 gearboxes. Two sets of field data were obtained from 64 gearboxes that were first-run to removal for cause, were refurbished and placed back in service, and then were second-run until removal for cause. A series of equations were empirically developed from the Monte Carlo simulation to determine the statistical variation in predicted life and Weibull slope as a function of the number of gearboxes failed. The resultant L-10 life from the field data was 5,627 h. From strict-series system reliability, the predicted L-10 life was 774 h. From the Monte Carlo simulation, the median value for the L-10 gearbox lives equaled 757 h. Half of the gearbox L-10 lives will be less than this value and the other half more. The resultant L10 life of the second-run (refurbished) gearboxes was 1,334 h. The apparent load-life exponent p for the roller bearings is 5.2. Were the bearing lives to be recalculated with a load-life exponent p equal to 5.2, the predicted L-10 life of the gearbox would be equal to the actual life obtained in the field. The component failure distribution of the gearbox from the Monte Carlo simulation was nearly identical to that using the strict-series system reliability analysis, proving the compatibility of these methods. C1 [Zaretsky, Erwin V.] NASA, Glenn Res Ctr, Cleveland, OH USA. [Lewicki, David G.] US Army Res Lab, Glenn Res Ctr, Cleveland, OH USA. [Savage, Michael] Univ Akron, Akron, OH 44325 USA. [Vlcek, Brian L.] Georgia So Univ, Statesboro, GA 30460 USA. RP Zaretsky, EV (reprint author), NASA, Glenn Res Ctr, Cleveland, OH USA. NR 29 TC 0 Z9 1 U1 1 U2 4 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 840 BUSSE HIGHWAY, PARK RIDGE, IL 60068 USA SN 1545-858X J9 TRIBOL LUBR TECHNOL JI Tribol. Lubr. Technol. PD JAN PY 2008 VL 64 IS 1 BP 40 EP 50 PG 11 WC Engineering, Mechanical SC Engineering GA 249NR UT WOS:000252236000012 ER PT J AU Rhee, IS AF Rhee, In-Sik TI Assessing the Biodegradability of Hydraulic Fluids Using a Bio-Kinetic Model SO TRIBOLOGY TRANSACTIONS LA English DT Article; Proceedings Paper CT 61st Annual Meeting of the Society-of-Tribologists-and-Lubrication-Engineers CY MAY 07-11, 2006 CL Calgary, CANADA SP Soc Tribologists & Lubricat Engineers DE Biodegradability; Hydraulic Fluids AB Throughout the industrial age, natural resources have been turned into products no longer recognizable by microorganisms and enzymes converting natural substances into their basic building bocks. To make more environmentally friendly products, significant efforts are being made to develop biodegradable materials and technologies fully compatible with the environment. One of the concerns in these efforts is the evaluation of their biodegradability in laboratory environments within a short period. Currently, several ASTM and OECD biodegradation test methods are available for determining this environmental property, but they take a long time (28 days) and special biological knowledge is required. To resolve this problem, a bio-kinetic model was developed to predict the biodegradability of hydraulic fluids. This report presents how to develop a bio-kinetic model and its results are discussed in a comparison with the modified Sturm test (ASTM D 5864) and the Aerobic Closed Respirometer test (ASTM D 6731). C1 USA, Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Rhee, IS (reprint author), USA, Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. NR 10 TC 1 Z9 1 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1040-2004 J9 TRIBOL T JI Tribol. Trans. PY 2008 VL 51 IS 1 BP 68 EP 73 DI 10.1080/10402000701739347 PG 6 WC Engineering, Mechanical SC Engineering GA 384FK UT WOS:000261730500004 ER PT J AU Dellacorte, C Radil, KC Bruckner, RJ Howard, SA AF Dellacorte, Christopher Radil, Kevin C. Bruckner, Robert J. Howard, S. Adam TI Design, fabrication, and performance of open source generation I and II compliant hydrodynamic gas foil bearings SO TRIBOLOGY TRANSACTIONS LA English DT Article DE foil bearings; fluid film bearings; turbines ID OIL-FREE TURBOMACHINERY; AIR BEARINGS AB Foil gas bearings are self-acting hydrodynamic bearings made from sheet metal foils comprised of at least two layers. The innermost top foil layer traps a gas pressure film that supports a load while a layer or layers underneath provide an elastic foundation. Foil bearings are used in many lightly loaded, high-speed turbomachines such as compressors used for aircraft pressurization and small microturbines. Foil gas bearings provide a means to eliminate the oil system leading to reduced weight and enhanced temperature capability. The general lack of familiarity of the foil bearing design and manufacturing process has hindered their widespread dissemination. This paper reviews the publicly available literature to demonstrate the design, fabrication, and performance testing of both first- and second-generation bump-style foil bearings. It is anticipated that this paper may serve as an effective starting point for new development activities employing foil bearing technology. C1 [Dellacorte, Christopher; Bruckner, Robert J.; Howard, S. Adam] NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. [Radil, Kevin C.] USA, Res Lab, Glenn Res Ctr, Cleveland, OH 44135 USA. RP Dellacorte, C (reprint author), NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. NR 37 TC 40 Z9 42 U1 1 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1040-2004 J9 TRIBOL T JI Tribol. Trans. PY 2008 VL 51 IS 3 BP 254 EP 264 DI 10.1080/10402000701772579 PG 11 WC Engineering, Mechanical SC Engineering GA 317ZD UT WOS:000257058100002 ER PT S AU Bennett, K AF Bennett, Kelly BE Carapezza, EM TI US army research laboratory (ARL) multimodal signatures database - art. no. 69631A SO UNATTENDED GROUND, SEA, AND AIR SENSOR TECHNOLOGIES AND APPLICATIONS X SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE Multimodal signatures; database; web interface; platform independence; Hierarchical Data Format 5 (HDF5); MATLAB; GNU Octave; Python; TML; SensorML; Java; distributed computing; interactive; servlets; JSP AB The U.S. Army Research Laboratory (ARL) Multimodal Signatures Database (MMSDB) is a centralized collection of sensor data of various modalities that are co-located and co-registered. The signatures include ground and air vehicles, personnel, mortar, artillery, small arms gunfire from potential sniper weapons, explosives, and many other high value targets. This data is made available to Department of Defense (DoD) and DoD contractors, Intel agencies, other government agencies (OGA), and academia for use in developing target detection, tracking, and classification algorithms and systems to protect our Soldiers. A platform independent Web interface disseminates the signatures to researchers and engineers within the scientific community. Hierarchical Data Format 5 (HDF5) signature models provide an excellent solution for the sharing of complex multimodal signature data for algorithmic development and database requirements. Many open source tools for viewing and plotting HDF5 signatures are-available over the Web. Seamless integration of HDF5 signatures is possible in both proprietary computational environments, such as MATLAB, and Free and Open Source Software (FOSS) computational environments, such as Octave and Python, for performing signal processing, analysis, and algorithm development. Future developments include extending the Web interface into a portal system for accessing ARL algorithms and signatures, High Performance Computing (HPC) resources, and integrating existing database and signature architectures into sensor networking environments. C1 USA, Res Lab, Sensors & Electron Devices Directorate, Hanover, NH 03755 USA. RP Bennett, K (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Hanover, NH 03755 USA. NR 7 TC 1 Z9 1 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7154-3 J9 P SOC PHOTO-OPT INS PY 2008 VL 6963 BP A9631 EP A9631 DI 10.1117/12.784185 PG 8 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BIC16 UT WOS:000258327100039 ER PT S AU Scanlon, MV AF Scanlon, Michael V. BE Carapezza, EM TI Helmet-mounted acoustic array for hostile fire detection and localization in an urban environment - art. no. 69630D SO UNATTENDED GROUND, SEA, AND AIR SENSOR TECHNOLOGIES AND APPLICATIONS X SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE AB The detection and localization of hostile weapons firing has been demonstrated successfully with acoustic sensor arrays on unattended ground sensors (UGS), ground-vehicles, and unmanned aerial vehicles (UAVs). Some of the more mature systems have demonstrated significant capabilities and provide direct support to ongoing counter-sniper operations. The Army Research Laboratory (ARL) is conducting research and development for a helmet-mounted system to acoustically detect and localize small arms firing, or other events such as RPG, mortars, and explosions, as well as other non-transient signatures. Since today's soldier is quickly being asked to take on more and more reconnaissance, surveillance, & target acquisition (RSTA) functions, sensor augmentation enables him to become a mobile and networked sensor node on the complex and dynamic battlefield. Having a body-worn threat detection and localization capability for events that pose an immediate danger to the soldiers around him can significantly enhance their survivability and lethality, as well as enable him to provide and use situational awareness clues on the networked battlefield. This paper addresses some of the difficulties encountered by an acoustic system in an urban environment. Complex reverberation, multipath, diffraction, and signature masking by building structures makes this a very harsh environment for robust detection and classification of shockwaves and muzzle blasts. Multifunctional acoustic detection arrays can provide persistent surveillance and enhanced situational awareness for every soldier. C1 USA, Res Lab, AMSRD ARL SE SP, Adelphi, MD 20783 USA. RP Scanlon, MV (reprint author), USA, Res Lab, AMSRD ARL SE SP, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 11 TC 1 Z9 1 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7154-3 J9 P SOC PHOTO-OPT INS PY 2008 VL 6963 BP D9630 EP D9630 DI 10.1117/12.784471 PG 13 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BIC16 UT WOS:000258327100008 ER PT S AU Sartain, RB AF Sartain, Ronald B. BE Carapezza, EM TI Profiling sensor for ISR applications - art. no. 69630Q SO UNATTENDED GROUND, SEA, AND AIR SENSOR TECHNOLOGIES AND APPLICATIONS X SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE profiling; unattended; ground; UGS; NIR; MWIR; LWIR; visible; infrared; ISR AB This paper addresses a new type of sensor that we are calling a profiling sensor. The profiling sensor collects sufficient information to classify objects reliably. In addition to meeting the classification requirement, the profiling sensor is inexpensive to build and maintain, will have a low unit production cost, uses a small amount of power, has a long battery life, and is very low weight. A variety of concepts are presented along with human signatures from one specific profiling sensor. In addition the paper includes a discussion of different concepts or architectures for profiling sensors as a function of potential applications. C1 USA, Res Lab, AMSRD ARL SE SE, Adelphi, MD 20783 USA. RP Sartain, RB (reprint author), USA, Res Lab, AMSRD ARL SE SE, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7154-3 J9 P SOC PHOTO-OPT INS PY 2008 VL 6963 BP Q9630 EP Q9630 DI 10.1117/12.796194 PG 11 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BIC16 UT WOS:000258327100020 ER PT S AU Cudney, HH Wilson, DK Ketcham, SA AF Cudney, Harley H. Wilson, D. Keith Ketcham, Stephen A. BE Carapezza, EM TI Implementing statistical acoustic characterization of urban terrain into a decision support tool SO UNATTENDED GROUND, SEA, AND AIR SENSOR TECHNOLOGIES AND APPLICATIONS X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE acoustic propagation; urban operations; statistical acoustics ID PROPAGATION; MEDIA AB Statistics-based characterizations of acoustic propagation, namely, fading and coherence, are being developed as functions of urban terrain zones. The fading and coherence curves are characterized for each of several urban terrain zones of interest, and the resulting curves are parameterized as a function of frequency and distance from the source. With the parameters for signal fading and coherence as a function of frequency, distance to source, and urban terrain zone type, the decision support tool SPEBE (Sensor Performance Evaluator for Battle-space Environments) is extended to urban areas. Combined with a separate effort characterizing background noise levels as functions also of urban terrain zones, a tool for predicting probability of detection for various sources in urban areas is demonstrated. C1 [Cudney, Harley H.; Wilson, D. Keith; Ketcham, Stephen A.] USA, Corps Engineers, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Cudney, HH (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Hanover, NH 03755 USA. EM harley.h.cudney@us.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 17 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7154-3 J9 PROC SPIE PY 2008 VL 6963 AR 69630I DI 10.1117/12.777182 PG 12 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BIC16 UT WOS:000258327100013 ER PT S AU Damarla, TR Ufford, D AF Damarla, T. Raju Ufford, David BE Carapezza, EM TI Helicopter detection using harmonies and seismic-acoustic coupling SO UNATTENDED GROUND, SEA, AND AIR SENSOR TECHNOLOGIES AND APPLICATIONS X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE helicopter detection; acoustic and seismic coupling; rotor harmonics; sound pressure level AB Unattended ground sensors (UGS) are routinely used to collect intelligence, surveillance, and reconnaissance (ISR) information. Unattended ground sensors consisting of. microphone array and geophone ate employed to detect rotary wing aircraft. This paper presents an algorithm for the detection of helicopters based on a fusion of rotor harmonics and acoustic-seismic coupling. The main rotor blades of helicopters operate at a fixed RPM to-prevent stalling or mechanical damage. In addition, the seismic spectrum is dominated by the acoustic-seismic coupling generated by these rotors; much more so than ground vehicles and other targets where mechanical coupling and a more broadband acoustic source are strong factors. First, an autocorrelation detection method identifies the constant fundamental generated by the helicopter main rotor. Second, key matching frequencies between the acoustic and seismic spectrum are used to, locate-possible coupled components. Detection can then be based on the ratio of the coupled seismic energy to total seismic energy. The results of the two methods are fused over a few seconds time to provide an initial and continued detection of a helicopter-within the sensor range. Performance is measured on data as a function of range and sound pressure level (SPL). C1 [Damarla, T. Raju; Ufford, David] USA, Res Lab, Adelphi, MD 20783 USA. RP Damarla, TR (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM rdamarla@arl.army.mil NR 7 TC 0 Z9 0 U1 2 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7154-3 J9 PROC SPIE PY 2008 VL 6963 AR 69630W DI 10.1117/12.776899 PG 6 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BIC16 UT WOS:000258327100025 ER PT S AU Edelstein, AS Burnette, J Fischer, GA Cheng, SF Egelhoff, WF Pong, PWT Nowak, ER AF Edelstein, A. S. Burnette, J. Fischer, G. A. Cheng, S. F. Egelhoff, W. F., Jr. Pong, P. W. T. Nowak, E. R. CA Univ Delaware BE Carapezza, EM TI Advances in magnetometry SO UNATTENDED GROUND, SEA, AND AIR SENSOR TECHNOLOGIES AND APPLICATIONS X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE magnetic; sensor; noise ID ROOM-TEMPERATURE; MAGNETIC SENSORS; MAGNETORESISTANCE; NOISE; FLUCTUATIONS AB Innovations may lead to magnetic sensors with superior performance. Examples of this are the chip scale atomic magnetometer, magnetic tunnel junctions with MgO barriers, and a device for minimizing the effect of 1/f noise, the MEMS flux concentrator. In the chip scale atomic magnetometer, researchers have been able to fabricate the light source, optics, heater, optical cell, and photodiode detector in a stack that passes through a silicon wafer. Theoretical and subsequent experimental work has led to the observation of magnetoresistance values of 400% at room temperature in magnetic tunnel junctions with MgO barriers. The MEMS flux concentrator has the potential to increase the sensitivity of magnetic sensors at low frequencies by more than an order of magnitude. The MEMS flux concentrator does this by shifting the operating frequency to higher frequencies where the1/f noise is much smaller. The shift occurs because the motion of flux concentrators on MEMS flaps modulates the field at kHz frequencies at the position of the sensor. C1 [Edelstein, A. S.; Burnette, J.; Fischer, G. A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Edelstein, AS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Edelstein@arl.army.mil NR 24 TC 0 Z9 0 U1 1 U2 6 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7154-3 J9 PROC SPIE PY 2008 VL 6963 AR 696315 DI 10.1117/12.784388 PG 9 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BIC16 UT WOS:000258327100034 ER PT S AU Ketcham, SA Wilson, DK Parker, MW Cudney, HH AF Ketcham, Stephen A. Wilson, D. Keith Parker, Michael W. Cudney, Harley H. BE Carapezza, EM TI Signal fading curves from computed urban acoustic wave fields SO UNATTENDED GROUND, SEA, AND AIR SENSOR TECHNOLOGIES AND APPLICATIONS X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE urban; acoustic; scattering; fading; multi-path; sound; propagation; computations AB Future US Army ground sensors in urban terrain will process acoustic signals to detect, classify, and locate sources of interest. Optimal processing will require understanding of the effects of the urban infrastructure on sound propagation. These include multi-path phenomena that must be accounted for in sensor placement and performance algorithms. This work applies Fourier analysis to urban acoustic wave-field data from three-dimensional high-performance computations to generate statistical measures of signal fading caused by scattering. The work calculates these measures from ratios of Fourier transforms of wave-field signals with and without scattering to isolate the structure-induced scattering. C1 [Ketcham, Stephen A.; Wilson, D. Keith; Parker, Michael W.; Cudney, Harley H.] USA, Engn Res & Dev Ctr, Hanover, NH 03755 USA. RP Ketcham, SA (reprint author), USA, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 8 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7154-3 J9 PROC SPIE PY 2008 VL 6963 AR 69630K DI 10.1117/12.777166 PG 8 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BIC16 UT WOS:000258327100014 ER PT S AU Morcos, A Grasing, D Desai, S AF Morcos, Amir Grasing, David Desai, Sachi BE Carapezza, EM TI Artillery/mortar type classification based on detected acoustic transients SO UNATTENDED GROUND, SEA, AND AIR SENSOR TECHNOLOGIES AND APPLICATIONS X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unattended Ground, Sea, and Air Sensor Technologies and Applications X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE mortar; artillery; quadratic classifier; statistical analysis; acoustic sensors; and classification AB Feature extraction methods based on the statistical analysis of the change in event pressure levels over a period and the level of ambient pressure excitation facilitate the development of a robust classification algorithm. The features reliably discriminates mortar and artillery variants via acoustic signals produced during the launch events. Utilizing acoustic sensors to exploit the sound waveform generated from the blast for the identification of mortar and artillery variants as type A, etcetera through analysis of the waveform. Distinct characteristics arise within the different mortar/artillery variants because varying HE mortar payloads and related charges emphasize varying size events at launch. The waveform holds various harmonic properties distinct to a given mortar/artillery variant that through advanced signal processing and data mining techniques can employed to classify a given type. The skewness and other statistical processing techniques are used to extract the predominant components from the acoustic signatures at ranges exceeding 3000m. Exploiting these techniques will help develop a feature set highly independent of range, providing discrimination based on acoustic elements of the blast wave. Highly reliable discrimination will be achieved with a feed-forward neural network classifier trained on a feature space derived from the distribution of statistical coefficients, frequency spectrum, and higher frequency details found within different energy bands. The processes that are described herein extend current technologies, which emphasis acoustic sensor systems to provide such situational awareness. C1 [Morcos, Amir; Grasing, David; Desai, Sachi] USA, RDECOM, Picatinny Arsenal, NJ 07806 USA. RP Morcos, A (reprint author), USA, RDECOM, Picatinny Arsenal, NJ 07806 USA. EM amir.morcos@us..army.mil; david.grasing@us.army.mil; sachi.desai@us..army.mil NR 6 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7154-3 J9 PROC SPIE PY 2008 VL 6963 AR 69630F DI 10.1117/12.777892 PG 8 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BIC16 UT WOS:000258327100010 ER PT S AU Bodt, BA Camden, R AF Bodt, Barry A. Camden, Richard BE Gerhart, GR Gage, DW Shoesmaker, CM TI Detecting and tracking moving humans from a moving vehicle - art. no. 696207 SO UNMANNED SYSTEMS TECHNOLOGY X SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE unmanned ground vehicle; experimental design; pedestrian tracking; perception; safety; planning AB In September 2007 the Army Research Laboratory (ARL) Robotics Collaborative Technology Alliance (CTA) conducted an assessment of multiple pedestrian detection algorithms based upon LADAR or video sensor data. Eight detection algorithms developed by the Robotics CTA member organizations, including ARL, were assessed in an experiment conducted by the National Institute of Science & Technology (NIST) and ARL to determine the probability of detection/misclassification and false alarm rate as a function of vehicle speed, degree of environmental clutter, and pedestrian speeds. The study is part of an ongoing investigation of safe operations for unmanned ground vehicles. This assessment marked the first time in this program that human movers acted as targets for detection from a moving vehicle. A focus of the study was to choreograph repeatable human movement scenarios relative to the movement of the vehicle. The resulting data is intended to support comparative analysis across treatment conditions and to allow developers to examine performance with respect to specific detection and tracking events. Events include humans advancing and retreating from the vehicle at different angles, humans crossing paths in close proximity and occlusion situations where sight to the mover from the sensor system is momentarily lost. A detailed operational procedure ensured repeatable human movement with independent ground truth supplied by a NIST ultra wideband wireless tracking system. Post processing and statistical analysis reconciled the tracking algorithm results with the NIST ground truth. We will discuss operational considerations and results. C1 [Bodt, Barry A.] USA, Res Lab, ATTN AMSRD ARL Cl CT, Aberdeen Proving Ground, MD 21005 USA. RP Bodt, BA (reprint author), USA, Res Lab, ATTN AMSRD ARL Cl CT, Aberdeen Proving Ground, MD 21005 USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7153-6 J9 P SOC PHOTO-OPT INS PY 2008 VL 6962 BP 96207 EP 96207 DI 10.1117/12.781864 PG 12 WC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BHY01 UT WOS:000257316300006 ER PT S AU O'Brien, BJ Young, SH AF O'Brien, Barry J. Young, Stuart H. BE Gerhart, GR Gage, DW Shoesmaker, CM TI Small robot autonomy in an integrated environment - art. no. 69620D SO UNMANNED SYSTEMS TECHNOLOGY X SE PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE autonomous mobility; SUGV; architecture; robotics; obstacle detection; obstacle avoidance AB The U.S. Army Research Laboratory's (ARL) Computational and Information Sciences Directorate (CISD) has long been involved in autonomous asset control, specifically as it relates to small robots. Over the past year, CISD has demonstrated the ability to control and view streaming video from an FCS-surrogate PackBot robotic system over multiple network types (Soldier Radio Waveform (SRW), 802.11), as well as tasking the robot to follow both manually (ARL Digitallnk) and autonomously planned (CERDEC C2ORE) GPS waypoint routes. These capabilities remove the "stand alone system" limitations of traditional small robot systems and allow any and all data produced by such platforms to be available to anyone on the network, while at the same time reducing the amount of operator intervention required to utilize a robot. However, assumptions were made about the paths the robot was to traverse, specifically that they would be free from major obstacles. To address these system limitations, CISD is implementing obstacle detection and avoidance (OD/OA) on the PackBot. The OD/OA utilizes COTS ranging sensors with indoor and/or outdoor capabilities, and leverages existing software algorithm components into the existing CISD robotic control architecture. These new capabilities are available in an integrated environment consisting of common command and control (C2) and network interfaces and on multiple platforms (ARL ATRV, LynchBot, PackBot, etc.) due to the modular and platform/network independent architecture that ARL employs. This paper will describe the current robotic control architecture employed by ARL and provide brief descriptions of existing capabilities. Further, the paper will discuss the small robot obstacle detection/avoidance integration effort performed by ARL, along with some preliminary results on its performance and benefits. C1 [O'Brien, Barry J.; Young, Stuart H.] USA, Res Lab, Adelphi, MD 20783 USA. RP O'Brien, BJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 17 TC 3 Z9 3 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7153-6 J9 P SOC PHOTO-OPT INS PY 2008 VL 6962 BP D9620 EP D9620 DI 10.1117/12.779211 PG 12 WC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BHY01 UT WOS:000257316300011 ER PT S AU Karlsen, RE Witus, G AF Karlsen, Robert E. Witus, Gary BE Gerhart, GR Gage, DW Shoesmaker, CM TI Adaptive learning applied to terrain recognition SO UNMANNED SYSTEMS TECHNOLOGY X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE robotics; vision; learning; terrain; classification; trafficability ID CLASSIFICATION AB This paper presents an exploration of methods for estimating terrain trafficability from visual appearance. Two different sets of data are used. The first set is extracted from video sequences and has a small number of different terrains. A fuzzy c-means clustering algorithm is used to predict terrain type. The second set is derived from high-resolution still images and has a large variety of terrains. A decision tree algorithm is used to provide a subjective assessment of trafficability. A variety of local features are explored, based on color and texture, as input to the learning algorithms. C1 [Karlsen, Robert E.] USA, TARDEC, Warren, MI 48397 USA. RP Karlsen, RE (reprint author), USA, TARDEC, Warren, MI 48397 USA. EM witusg@umich.edu NR 15 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7153-6 J9 PROC SPIE PY 2008 VL 6962 AR 69620H DI 10.1117/12.777289 PG 10 WC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BHY01 UT WOS:000257316300014 ER PT S AU Knichel, DG Bruemmer, DJ AF Knichel, David G. Bruemmer, David J. BE Gerhart, GR Gage, DW Shoesmaker, CM TI From the laboratory to the soldier providing tactical behaviors for Army robots SO UNMANNED SYSTEMS TECHNOLOGY X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE AB The Army Future Combat System (FCS) Operational Requirement Document has identified a number of advanced robot tactical behavior requirements to enable the Future Brigade Combat Team (FBCT). The FBCT advanced tactical behaviors include Sentinel Behavior, Obstacle Avoidance Behavior, and Scaled Levels of Human-Machine control Behavior. The U.S. Army Training and Doctrine Command, (TRADOC) Maneuver Support Center (MANSCEN) has also documented a number of robotic behavior requirements for the Army non FCS forces such as the Infantry Brigade Combat Team (IBCT), Stryker Brigade Combat Team (SBCT), and Heavy Brigade Combat Team (HBCT). The general categories of useful robot tactical behaviors include Ground/Air Mobility behaviors, Tactical Mission behaviors, Manned-Umnanned Teaming behaviors, and Soldier-Robot Interface behaviors. Many DoD research and development centers are achieving the necessary components necessary for artificial tactical behaviors for ground and air robots to include the Army Research Laboratory (ARL), U.S. Army Research, Development and Engineering Command (RDECOM), Space and Naval Warfare (SPAWAR) Systems Center, US Army Tank-Automotive Research, Development and Engineering Center (TARDEC) and non DoD labs such as Department of Energy (DOL). With the support of the Joint Ground Robotics Enterprise (JGRE) through DoD and non DoD labs the Army Maneuver Support Center has recently concluded successful field trails of ground and air robots with specialized tactical behaviors and sensors to enable semi autonomous detection, reporting, and marking of explosive hazards to include Improvised Explosive Devices (IED) and landmines. A specific goal of this effort was to assess how collaborative behaviors for multiple unmanned air and ground vehicles can reduce risks to Soldiers and increase efficiency for on and off route explosive hazard detection, reporting, and marking. This paper discusses experimental results achieved with a robotic countermine system that utilizes autonomous behaviors and a mixed-initiative control scheme to address the challenges of detecting and marking buried landmines. Emerging requirements for robotic countermine operations are outlined as are the technologies developed under this effort to address them. A first experiment shows that the resulting system was able to find and mark landmines with a very low level of human involvement. In addition, the data indicates that the robotic system is able to decrease the time to find mines and increase the detection accuracy and reliability. Finally, the paper presents current efforts to incorporate new countermine sensors and port the resulting behaviors to two fielded military systems for rigorous assessing. C1 [Knichel, David G.] USA, Maneuver Support Ctr, Ft Leonard Wood, MO 65473 USA. RP Knichel, DG (reprint author), USA, Maneuver Support Ctr, Ft Leonard Wood, MO 65473 USA. NR 7 TC 0 Z9 0 U1 2 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7153-6 J9 PROC SPIE PY 2008 VL 6962 AR 69621M DI 10.1117/12.781303 PG 9 WC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BHY01 UT WOS:000257316300048 ER PT S AU Rogers, JR AF Rogers, John R. BE Gerhart, GR Gage, DW Shoesmaker, CM TI Low-cost robotic arm control SO UNMANNED SYSTEMS TECHNOLOGY X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE teleoperation; master-slave; manipulator; low-cost; robotic arm; radio control ID TELEOPERATION; DELAY AB A low-cost robotic arm and controller system is presented. The controller is a desktop model of the robotic arm with the same degrees of freedom whose joints are equipped with sensors. Manipulating the controller by hand causes the robotic arm to mimic the movement in maser-slave fashion. The system takes advantage of the low cost and wide availability of hobby radio control components and uses a low-cost, easy-to-program microprocessor. The system is implemented with a video camera on the robotic arm, and the arm is mounted on an unmanned omnidirectional vehicle inspection robot. With a camera on the end of a robot arm, the vehicle inspection system can reach difficult to-access regions of the vehicle underbody. Learning to manipulate the robot arm with this controller is faster than learning with a traditional joystick. Limitations of the microcontroller are discussed, and suggestions for further development of the robot arm and control are made. C1 US Mil Acad, West Point, NY USA. RP Rogers, JR (reprint author), US Mil Acad, West Point, NY USA. EM john.rogers@usma.edu NR 10 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7153-6 J9 PROC SPIE PY 2008 VL 6962 AR 696212 DI 10.1117/12.784331 PG 11 WC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BHY01 UT WOS:000257316300033 ER PT S AU Schoenherr, E Theisen, BL Animashaun, A Davis, J AF Schoenherr, Edward Theisen, Bernard L. Animashaun, Asisat Davis, James CA LTC Christopher Day BE Gerhart, GR Gage, DW Shoesmaker, CM TI Convoy Active Safety Technologies Warfighter Experiment I SO UNMANNED SYSTEMS TECHNOLOGY X SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology X CY MAR 17-20, 2008 CL Orlando, FL SP SPIE DE autonomous; convoy; situational awareness; mobility; sustainment; obstacle avoidance; follower AB The operational ability to project and sustain forces in distant, anti-access and area denial environments poses new challenges for combatant commanders. One of the new challenges is the ability to conduct sustainment operations at operationally feasible times and places on the battlefield. Combatant commanders require a sustainment system that is agile, versatile, and survivable throughout the range of military operations and across the spectrum of conflict. A key component of conducting responsive, operationally feasible sustainment operations is the ability to conduct sustainment convoys. Sustainment convoys are critical to providing combatant commanders the right support, at the right time and place, and in the right quantities, across the full range of military operations. The ability to conduct sustainment convoys in a variety of hostile environments require force protection measures that address the enemy threat and protect the Soldier. One cost effective, technically feasible method of increasing the force protection for sustainment convoys is the use of robotic follower technology and autonomous navigation. The Convoy Active Safety Technologies (CAST) system is a driver assist, convoy autopilot technology aimed to address these issues. Warfigher Experiment I, held at A.P. Hill, VA in the fall of 2007, tested the utility of this vehicle following technology not only in measures of system integrity and performance vs. manual driving, but also the physiological effects on the operators themselves. This paper will detail the Warfigher Experiment's methodology, analysis, results and conclusions. C1 [Schoenherr, Edward; Theisen, Bernard L.] USA, Tank Automot Res Dev & Engn Ctr, Warren, MI USA. RP Schoenherr, E (reprint author), USA, Tank Automot Res Dev & Engn Ctr, Warren, MI USA. EM edward.schoenherr@gmail.com NR 9 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7153-6 J9 PROC SPIE PY 2008 VL 6962 AR 69621N DI 10.1117/12.780357 PG 12 WC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology SC Robotics; Remote Sensing; Optics; Imaging Science & Photographic Technology GA BHY01 UT WOS:000257316300049 ER PT B AU Waxman, SW Morey, AF AF Waxman, Steve W. Morey, Allen F. BE Brandes, SB TI Reconstruction of Failed Urethroplasty SO URETHRAL RECONSTRUCTIVE SURGERY SE Current Clinical Urology LA English DT Article; Book Chapter DE recurrent stricture; salvage urethroplasty; onlay flap; patch grafting; extended meatotomy; penile skin ID BULBAR URETHRAL RECONSTRUCTION; BUCCAL MUCOSA; GRAFT URETHROPLASTY; POSTERIOR URETHROPLASTY; ANTERIOR URETHROPLASTY; ONLAY URETHROPLASTY; URINARY-TRACT; STRICTURES; PENILE; FLAP AB While initial open urethroplasty has a success rate of approximately 90%, salvage repairs do not fare as well, having a success rate of roughly 80% on average. Failed anastomotic repairs are usually the result of an inadequate excision of fibrotic tissue and/or inadequate distal urethral mobilization, resulting in an anastomosis performed under tension. The mainstay of treatment for recurrent penile urethral strictures remains a nap procedure with penile shaft skin. It is crucial to resect redundant sacculations, residual scar, or hair-bearing tissue remaining from prior procedures at the time of reconstruction. If distal stenosis Should occur after a flap procedure, extended meatotomy is highly effective. Strictures most amenable to excision with re-anastomosis are those in the proximal bulb-these allow for maximal use of the elastic properties of the distal bulbar urethra to bridge the gap created once the scarred segment is excised. For strictures greater than 3 cm. in length located in the distal bulb, patch graft (penile skin or buccal mucosa) is the most effective and efficient approach. The primary reason for failure of a primary open Urethroplasty of the posterior urethra is inadequate exposure of the prostatic apex, resulting in incomplete excision of scar tissue. Urethral stenosis may recur after any of the above types of open urethral reconstruction-fortunately the recurrent stricture is often short and web-like. and usually responds well to a single urethral balloon dilation or direct visual internal Urethrotomy, because it is associated with less underlying spongiofibrosis. C1 [Waxman, Steve W.] Brooke Army Med Ctr, Dept Urol, Ft Sam Houston, TX 78234 USA. [Morey, Allen F.] Univ Texas Southwestern Med Sch, Dept Urol, Dallas, TX USA. [Morey, Allen F.] Parkland Mem Hosp & Affiliated Inst, Dallas, TX USA. RP Waxman, SW (reprint author), Brooke Army Med Ctr, Dept Urol, Ft Sam Houston, TX 78234 USA. NR 32 TC 0 Z9 0 U1 1 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-58829-826-3 J9 CURR CLIN UROL PY 2008 BP 269 EP 276 DI 10.1007/978-1-59745-103-1_23 D2 10.1007/978-1-59745-103-1 PG 8 WC Surgery; Urology & Nephrology SC Surgery; Urology & Nephrology GA BJR66 UT WOS:000267047700023 ER PT J AU Amemiya, K AF Amemiya, K. TI Protection mediated by the Yersinia pestis F1-V plague vaccine in two animal models of plague: a contrast in immune response in murine and nonhuman primates SO VACCINE LA English DT Meeting Abstract CT 2nd Vaccine Congress CY DEC 07-09, 2008 CL Boston, MA DE Plague; vaccine; Mouse; Nonhuman primate C1 [Amemiya, K.] USA, Med Res Inst Infect Dis, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PY 2008 PG 2 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 480QF UT WOS:000268750600134 ER PT J AU Peters, CJ Pittman, P Morrill, JC Bettinger, GE Lokukamage, N Ranadive, M AF Peters, C. J. Pittman, P. Morrill, J. C. Bettinger, G. E. Lokukamage, N. Ranadive, M. TI Genetic and clinical evaluation of MP-12: a live attenuated vaccine for Rift Valley fever virus (RVFV) SO VACCINE LA English DT Meeting Abstract CT 2nd Vaccine Congress CY DEC 07-09, 2008 CL Boston, MA DE Rift Valley fever; Vaccine; Clinical trial; safety C1 [Peters, C. J.; Morrill, J. C.; Bettinger, G. E.; Lokukamage, N.] Univ Texas Med Branch, Galveston, TX USA. [Pittman, P.; Ranadive, M.] USA, Med Res Inst Infect Dis, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PY 2008 PG 1 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 480QF UT WOS:000268750600044 ER PT B AU Zuhur, S AF Zuhur, Sherifa BE Heath, J TI From Veil to Veil "What's in a woman's head is a lot more important than what's on it" SO VEIL: WOMEN WRITERS ON ITS HISTORY, LORE, AND POLITICS LA English DT Article; Book Chapter C1 USA, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. RP Zuhur, S (reprint author), USA, War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU UNIV CALIFORNIA PRESS PI BERKELEY PA 2120 BERKELEY WAY, BERKELEY, CA 94720 USA BN 978-0-52094-160-1 PY 2008 BP 307 EP 318 PG 12 WC Literary Theory & Criticism SC Literature GA BXG52 UT WOS:000296079900020 ER PT S AU Goldberg, E AF Goldberg, Eugene BE Logozzo, F Peled, DA Zuck, LD TI On bridging simulation and formal verification SO VERIFICATION, MODEL CHECKING, AND ABSTRACT INTERPRETATION SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 9th International Conference on Verification, Model Checking, and Abstract Interpretation CY JAN 07-09, 2008 CL San Francisco, CA SP Univ Illinois, Chicago, Microsoft AB Simulation and formal verification are two complementary techniques for checking the correctness of hardware and software designs. Formal verification proves that a design property holds for all points of the search space while simulation checks this property by probing the search space at a subset of points. A known fact is that simulation works surprisingly well taking into account the negligible part of the search space covered by test points. We explore this phenomenon by the example of the satisfiability problem (SAT). We believe that the success of simulation can be understood if one interprets a set of test points not as a sample of the search space, but as an "encryption" of a formal proof. We introduce the notion of a sufficient test set of a CNF formula as a test set encrypting a formal proof that this formula is unsatisfiable. We show how sufficient test sets can be built. We discuss applications of tight sufficient test sets for testing technological faults (manufacturing testing) and design changes (functional verification) and give some experimental results. C1 USA, Cadence Res Labs, Berkeley, CA USA. RP Goldberg, E (reprint author), USA, Cadence Res Labs, 2150 Shattuck Ave,10th Floor, Berkeley, CA USA. EM egold@cadence.com NR 9 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-540-78162-2 J9 LECT NOTES COMPUT SC PY 2008 VL 4905 BP 127 EP 141 PG 15 WC Computer Science, Hardware & Architecture; Computer Science, Theory & Methods SC Computer Science GA BHK95 UT WOS:000253940200014 ER PT S AU David, P AF David, Philip BE Rahman, Z Reichenbach, SE Neifeld, MA TI Detection of building facades in urban environments SO VISUAL INFORMATION PROCESSING XVII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Visual Information Processing XVII CY MAR 18-19, 2008 CL Orlando, FL SP SPIE DE planar surface segmentation; building recognition; facade detection ID POINTS AB We describe an approach to automatically detect building facades in images of urban environments. This is an important problem in vision-based navigation, landmark recognition, and surveillance applications. In particular, with the proliferation of GPS- and camera-enabled cell phones, a backup geolocation. system is needed when GPS satellite signals are blocked in so-called "urban canyons". Image line segments are first located, and then the vanishing points of these segments are determined using the RANSAC robust estimation algorithm. Next, the intersections of line segments associated with pairs of vanishing points are used to generate local support for planar facades at different orientations. The plane support points are then clustered using an algorithm that requires no knowledge of the number of clusters or of their spatial proximity. Finally, building facades are identified by fitting vanishing point-aligned quadrilaterals to the clustered support points. Our experiments show good performance in a number of complex urban environments. The main contribution-of our approach is its improved performance over existing approaches while placing no constraints on the facades in terms of their number or orientation, and minimal constraints on the length of the detected line segments. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP David, P (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7169-7 J9 PROC SPIE PY 2008 VL 6978 AR 69780P DI 10.1117/12.779280 PG 11 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Computer Science; Engineering; Optics; Imaging Science & Photographic Technology GA BIA03 UT WOS:000257876900019 ER PT S AU Conti, G Dean, E Sinda, M Sangster, B AF Conti, Gregory Dean, Erik Sinda, Matthew Sangster, Benjamin BE Goodall, JR Conti, G Ma, KL TI Visual reverse engineering of binary and data files SO VISUALIZATION FOR COMPUTER SECURITY, PROCEEDINGS SE LECTURE NOTES IN COMPUTER SCIENCE LA English DT Proceedings Paper CT 5th International Workshop on Visulization for Cyber Security (VizSec 2008) CY SEP 15, 2008 CL MIT, Cambridge, MA HO MIT AB The analysis of computer files poses a difficult problem for security researchers seeking to detect and analyze malicious content, software developers stress testing file formats for their products, and for other researchers seeking to understand the behavior and structure of undocumented file formats. Traditional tools, including hex editors, disassemblers and debuggers, while powerful, constrain analysis to primarily text based approaches. In this paper, we present design principles for file analysis which support meaningful investigation when there is little or no knowledge of the underlying file format, but are flexible enough to allow integration of additional semantic information, when available. We also present results from the implementation of a visual reverse engineering system based on our analysis. We validate the efficacy of both our analysis and our system with case studies depicting analysis use cases where a hex editor would be of limited value. Our results indicate that visual approaches help analysts rapidly identify files, analyze unfamiliar file structures, and gain insights that inform and complement the current suite of tools currently in use. C1 [Conti, Gregory; Dean, Erik; Sinda, Matthew; Sangster, Benjamin] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Conti, G (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. NR 12 TC 7 Z9 8 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-540-85931-4 J9 LECT NOTES COMPUT SC PY 2008 VL 5210 BP 1 EP 17 PG 17 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BIG90 UT WOS:000259399800001 ER PT J AU Zuber, T AF Zuber, Terence TI Everybody knows there was a 'Schlieffen Plan': A reply to Annika Mombauer SO WAR IN HISTORY LA English DT Article AB According to Annika Mombauer. it is common knowledge that the Schlieffen plan proves German war guilt. Unfortunately, vox populi, vox dei does not make for good military history. C1 [Zuber, Terence] USA, Washington, DC 20310 USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 J9 WAR HIST JI War Hist. PD JAN PY 2008 VL 15 IS 1 BP 92 EP 101 DI 10.1177/0968344507085764 PG 10 WC History; International Relations SC History; International Relations GA 276SE UT WOS:000254161700005 ER PT J AU Koh, G Arcone, SA AF Koh, G. Arcone, S. A. TI A bistatic Doppler technique to measure forward scattering at large angles of incidence SO WAVES IN RANDOM AND COMPLEX MEDIA LA English DT Article ID TRACING PROPAGATION SIMULATION; ROUGH-SURFACE; TERRAIN; RADAR; ICE; PREDICTIONS; REFLECTION; MODELS AB We present a bistatic Doppler method to measure forward scatter at large angles of incidence. The Doppler shifted signal avoids contamination by the direct signal between antennae. We illuminated a small area on a rotating table with a 95-GHz transmitter pointed at 60-80 angles of incidence. The area velocity was nearly constant. The scattering media was crushed rock with root mean square (rms) height to wavelength ratio near unity. Although theory precludes Doppler shift for targets moving in the plane of bistatic collinear antennae, shifts occurred at the monostatic backscattering value predicted by twice the table velocity within the illuminated area. The Rayleigh distributions of the Doppler shifted signal, with increasing standard deviation and corresponding decreasing peak amplitude as angle of incidence increased, are expected for the unity ratio, and so verify that Doppler shifted forward scatter was measured. The increased standard deviation with increasing angle is expected because of the increased sensitivity to smaller slope facets of the rock. The reference signal recorded for a metal plate signal also verifies the bistatic Doppler shift and precludes contamination by multiply-reflected backscatter. Minor modifications will allow grazing angle behaviour to be approached. It appears that further theory is needed to understand the bistatic Doppler process. C1 [Koh, G.; Arcone, S. A.] USA, Cold Reg Res & Engn Lab, Erdc, Hanover, NH 03755 USA. RP Arcone, SA (reprint author), USA, Cold Reg Res & Engn Lab, Erdc, 72 Lyme Rd, Hanover, NH 03755 USA. EM steven.a.arcone@cerdc.usace.army.mil NR 28 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1745-5030 J9 WAVE RANDOM COMPLEX JI Waves Random Complex Media PY 2008 VL 18 IS 1 BP 53 EP 63 DI 10.1080/17455030701362577 PG 11 WC Physics, Multidisciplinary SC Physics GA 250ZQ UT WOS:000252340400004 ER PT J AU Vorontsov, AM Paramonov, PV Valley, MT Vorontsov, A AF Vorontsov, A. M. Paramonov, P. V. Valley, M. T. Vorontsov, A. TI Generation of infinitely long phase screens for modeling of optical wave propagation in atmospheric turbulence SO WAVES IN RANDOM AND COMPLEX MEDIA LA English DT Article ID NUMERICAL-SIMULATION; LASER-BEAMS; SCINTILLATION AB Numerical modeling of optical wave propagation in atmospheric turbulence is traditionally performed by using the so-called 'split'-operator method, where the influence of the propagation medium's refractive index inhomogeneities is accounted for only within a set of infinitely narrow phase distorting layers (phase screens). These phase screens are generated on a numerical grid of finite size, which corresponds to a rather narrow slice (spatial area) of atmospheric turbulence. In several important applications including laser target tracking, remote sensing, adaptive optics, and atmospheric imaging, optical system performance depends on atmospheric turbulence within an extended area that significantly exceeds the area associated with the numerical grid. In this paper we discuss methods that allow the generation of a family of long (including infinitely long) phase screens representing an extended (in one direction) area of atmospheric turbulence-induced phase distortions. This technique also allows the generation of long phase screens with spatially inhomogeneous statistical characteristics. C1 [Vorontsov, A. M.; Paramonov, P. V.; Vorontsov, A.] Moscow MV Lomonosov State Univ, Moscow, Russia. [Valley, M. T.; Vorontsov, A.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Vorontsov, A. M.; Paramonov, P. V.; Valley, M. T.; Vorontsov, A.] Univ Maryland, Army Res Lab, College Pk, MD 20742 USA. RP Vorontsov, A (reprint author), Moscow MV Lomonosov State Univ, Moscow, Russia. EM mvoronts@umd.edu NR 31 TC 16 Z9 16 U1 1 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1745-5030 J9 WAVE RANDOM COMPLEX JI Waves Random Complex Media PY 2008 VL 18 IS 1 BP 91 EP 108 DI 10.1080/17455030701429962 PG 18 WC Physics, Multidisciplinary SC Physics GA 250ZQ UT WOS:000252340400006 ER PT J AU Tong, MS Chew, WC White, MJ AF Tong, Mei Song Chew, Weng Cho White, Michael J. TI Surface impedance design with ground corrugation for mitigation of large-calibre gun blast noise SO WAVES IN RANDOM AND COMPLEX MEDIA LA English DT Article ID PROPAGATION; ARTILLERY; PREDICTION; REDUCTION; BARRIERS AB The surface impedance design approach is proposed for mitigating large-calibre gun blast noise. Surrounding the blast noise, we employ a group of concentric trenches with critical depths to dampen the propagation of the acoustic wave. These trenches behave like quarter-wavelength resonators and produce acoustic soft surfaces at their openings. The sound pressure is then mitigated over these soft surfaces by destructive interference and the wave attenuates rapidly along the ground surface. To evaluate the overall acoustic performance of such a design, we develop an efficient numerical solver by treating the geometry as a body of revolution (BOR). The symmetry of the structure in the revolution direction allows the 3D boundary integral equation (BIE) for acoustic wave scattering to be reduced to a 2D integral equation by the use of Fourier series expansions. Numerical experiments show that this model can effectively suppress the acoustic wave propagation horizontally and the reduction can reach about 15 dB for large-calibre gun noise with very low-frequency components. C1 [Tong, Mei Song; Chew, Weng Cho] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. [White, Michael J.] USA Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. RP Chew, WC (reprint author), Univ Illinois, Dept Elect & Comp Engn, 1406 W Green St, Urbana, IL 61801 USA. EM w-chew@uiuc.edu RI White, Michael/B-3612-2009; Chew, Weng Cho/C-1792-2009 OI White, Michael/0000-0001-8450-9135; NR 26 TC 1 Z9 1 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1745-5030 J9 WAVE RANDOM COMPLEX JI Waves Random Complex Media PY 2008 VL 18 IS 3 BP 461 EP 477 DI 10.1080/17455030802078437 PG 17 WC Physics, Multidisciplinary SC Physics GA 327OL UT WOS:000257738300007 ER PT J AU Slade, JG Poovey, AG Getsinger, KD AF Slade, Jeremy G. Poovey, Angela G. Getsinger, Kurt D. TI Concentration-exposure time relationships for controlling sago pondweed (Stuckenia pectinata) with endothall SO WEED TECHNOLOGY LA English DT Article DE aquatic weed control; chemical control; irrigation canals; submersed aquatic vegetation ID POTAMOGETON-PECTINATUS; EURASIAN WATERMILFOIL; AQUATIC HERBICIDES; CARBOHYDRATE ALLOCATION; IRRIGATION CHANNELS; CURLYLEAF PONDWEED; SEASONAL BIOMASS; WATER; HYDRILLA; EFFICACY AB The submersed macrophyte, sago pondweed, frequently grows to nuisance levels in water conveyance systems throughout the western United States and can cause problems in lakes, reservoirs, and other water bodies. The liquid dipotassium and dimethylalkylamine salt formulations of endothall were evaluated for controlling sago pondweed using short exposure times (3 to 24 h) under controlled environmental conditions (14: 10 h light: dark; 21.5 C). Endothall treatments ranged from 1 to 10 mg ai/L (dipotassium salt) and 0.5 to 5 mg ae/L (dimethylalkylamine salt). Sixteen concentration and exposure time (CET) combinations were evaluated in each study. At 4 wk after treatment, all CET combinations significantly reduced shoot biomass (43 to 99%) of sago pondweed compared with the untreated reference. Reduction in shoot biomass was greater in plants that received higher herbicide doses and longer exposure times. In addition, more than half of the endothall CET combinations controlled sago pondweed by at least 90%, with some providing > 98% control. At the endothall CETs evaluated, regrowth of sago pondweed could occur after 4 wk, and some level of retreatment might be required to maintain plant control throughout the growing season. Results indicate that endothall shows promise as an alternative vegetation management tool in flowing-water environments. C1 Mississippi State Univ, Dept Wildlife & Fisheries, Vicksburg, MS 39180 USA. USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Slade, JG (reprint author), Mississippi State Univ, Dept Wildlife & Fisheries, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jeremy.g.slade@erdc.usace.army.mil NR 45 TC 4 Z9 4 U1 1 U2 5 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0890-037X J9 WEED TECHNOL JI Weed Technol. PD JAN-MAR PY 2008 VL 22 IS 1 BP 146 EP 150 DI 10.1614/WT-07-121.1 PG 5 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA 277TN UT WOS:000254237700026 ER PT J AU Bolin, M Marklund, S Bliese, P AF Bolin, Malin Marklund, Staffan Bliese, Paul TI Organizational impact on psychosocial working conditions SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE multilevel analysis; JD-C model; job demands; control; organization ID DEMAND-CONTROL MODEL; MULTILEVEL ANALYSIS; STRESS; LEADERSHIP; EXPOSURE; SUPPORT AB Using a multilevel approach, this study explores how job demands and control are dependent on the organizational context in which work is performed. The data set consisted of 3,485 employees at 51 establishments divided into 141 sub-units and belonging to 10 parent organizations. Data were collected by means of a survey answered by the employees and structured interviews conducted with operative managers at participating establishments. The results showed that a significant proportion of the variance in job demands and control was attributed to the organization, and that the three organizational levels varied in terms of their impact on the two psychosocial dimensions. More specifically, job demands were mostly affected by the establishment level, while the sub-unit level seemed to be the most important for job control. It is concluded that in studies of working conditions, the organizational context should be considered. C1 [Bolin, Malin] Natl Inst Working Life, Dept Work & Hlth, SE-11391 Stockholm, Sweden. [Marklund, Staffan] Karolinska Inst, Stockholm, Sweden. [Bliese, Paul] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. RP Bolin, M (reprint author), Natl Inst Working Life, Dept Work & Hlth, SE-11391 Stockholm, Sweden. EM malin.bolin@ali.se NR 47 TC 4 Z9 4 U1 0 U2 9 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2008 VL 30 IS 4 BP 451 EP 459 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 341DT UT WOS:000258695100013 PM 18725708 ER PT J AU Tucker, JS Sinclair, RR Mohr, CD Adler, AB Thomas, JL Salvi, AD AF Tucker, Jennifer S. Sinclair, Robert R. Mohr, Cynthia D. Adler, Amy B. Thomas, Jeffrey L. Salvi, Angela D. TI A temporal investigation of the direct, interactive, and reverse relations between demand and control and affective strain SO WORK AND STRESS LA English DT Article; Proceedings Paper CT Conference on Work, Stress, and Health CY MAR 02-04, 2006 CL Miami, FL SP APA, NIOSH DE occupational stress; affective strain; Job Demand-Control model; longitudinal research; military personnel ID MODEL; WORK; PERFORMANCE; HEALTH; IMPACT; MULTILEVEL; STRESSORS; EFFICACY AB Few studies have tested how stressors affect outcomes over time. We sought to extend the literature by means of a longitudinal study testing for direct, interactive, and causal relations between demands and control and affective strain. We extended prior work testing causal relationships for Karasek's (1979) Job Demand-Control (JDC) model by examining both the effects of demands and control on strain and in turn the effects of strain on demand and control. We tested our hypotheses using hierarchical linear modelling with a military sample of 1539 soldiers who completed six waves of survey data at 3-month time lags. The results replicate earlier cross-sectional studies reporting effects of work characteristics on strain; however, in our study these effects did not persist past three months. The results also provide evidence for reverse causal effects such that higher strain was associated with higher subsequent work overload and lower control over a six month time period. Similar to past research, we did not find support for the interactive effects of work overload and control on strain. We discuss the implications of our findings for theory and practice (such as the optimum time for applying interventions during the management of change), especially in terms of understanding the specific time lags for different stress-strain associations and the need for additional theories to explain reverse relationships. C1 [Tucker, Jennifer S.; Sinclair, Robert R.; Mohr, Cynthia D.] Portland State Univ, Dept Psychol, Portland, OR 97207 USA. [Adler, Amy B.] USA, Walter Reed Army Inst Res, Med Res Unit Europe, Heidelberg, Germany. [Thomas, Jeffrey L.] Walter Reed Army Inst Res, Div Psychiat Neurosci, Silver Spring, MD USA. RP Tucker, JS (reprint author), Portland State Univ, Dept Psychol, Portland, OR 97207 USA. EM Jennifer.S.Tucker@us.army.mil NR 41 TC 9 Z9 10 U1 2 U2 9 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0267-8373 EI 1464-5335 J9 WORK STRESS JI Work Stress PY 2008 VL 22 IS 2 BP 81 EP 95 DI 10.1080/02678370802190383 PG 15 WC Psychology, Applied SC Psychology GA 321WI UT WOS:000257336800001 ER PT J AU Spinella, PC Perkins, JG Grathwohl, KW Repine, T Beekley, AC Sebesta, J Jenkins, D Azarow, K Holcomb, JB AF Spinella, Philip C. Perkins, Jeremy G. Grathwohl, Kurt W. Repine, Thomas Beekley, Alec C. Sebesta, James Jenkins, Donald Azarow, Kenneth Holcomb, John B. CA 31st CSH Res Working Grp TI Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during operation Iraqi freedom at a US combat support hospital SO WORLD JOURNAL OF SURGERY LA English DT Article ID LIFE-THREATENING COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; MASSIVE TRANSFUSION; TRAUMA PATIENT; INDEPENDENT CONTRIBUTIONS; CELL TRANSFUSION; CRITICALLY-ILL; DESERT-STORM; WAR; HYPOTHERMIA AB Background United States military doctrine permits the use of fresh whole blood (FWB), donated by U. S. military personnel on site, for casualties with life-threatening injuries at combat support hospitals. U. S. Military Medical Department policy dictates that all patients treated at military facilities during combat (coalition military personnel, foreign nationals, and enemy combatants) are to be treated equally. The objectives of this study were to describe admission vital signs and laboratory values and injury location for patients transfused with FWB, and to determine if FWB was employed equally among all patient personnel categories at a combat support hospital. Methods This retrospective cohort study evaluated admission vital signs and laboratory values, injury location, and personnel category for all patients receiving FWB at a U. S. Army combat support hospital in Baghdad, Iraq, between January and December 2004. Results Eighty-seven patients received 545 units of FWB. Upon admission, the average (+/- S.D.) heart rate was 144 bpm (+/- 25); systolic blood pressure, 106 mmHg (+/- 33); base deficit, 9 (+/- 6.5); hemoglobin, 9.0 g/dl (+/- 2.6); platelet concentration, 81.9 x 10(3)/mm(3) (+/- 81); international normalized ratio (INR), 2.0 (+/- 1.1); and temperature 95.7 degrees F (+/- 2.6). The percentages of intensive care patients who received FWB by personnel category were as follows: coalition soldiers, 51/592 (8.6%); foreign nationals, 25/347 (7.2%); and enemy combatants, 11/128 (8.5% ( p = 0.38). The amount of FWB transfused by personnel category was as follows: coalition soldier, 4 units (1-35); foreign national, 4 units (1-36); and enemy combatant, 4 units (1-11) (p = 0.9). Conclusions Fresh whole blood was used for anemic, acidemic, hypothermic, coagulopathic patients with life-threatening traumatic injuries in hemorrhagic shock, and it was transfused in equal percentages and amounts for coalition soldiers, foreign nationals, and enemy combatants. C1 [Spinella, Philip C.; Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. [Grathwohl, Kurt W.] Brooke Army Med Ctr, San Antonio, TX USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Repine, Thomas] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Beekley, Alec C.; Sebesta, James; Azarow, Kenneth] Madigan Army Med Ctr, Washington, DC USA. [Jenkins, Donald] Willard Hall Air Force Med Ctr, San Antonio, TX USA. [Spinella, Philip C.] Connecticut Childrens Med Ctr, Hartford, CT USA. RP Spinella, PC (reprint author), USA, Inst Surg Res, San Antonio, TX USA. EM pspinella@ccmckids.org NR 47 TC 29 Z9 33 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0364-2313 J9 WORLD J SURG JI World J.Surg. PD JAN PY 2008 VL 32 IS 1 BP 2 EP 6 DI 10.1007/s00268-007-9201-5 PG 5 WC Surgery SC Surgery GA 243LE UT WOS:000251797400001 PM 17990028 ER PT J AU Brasfield, SM Talent, LG Janz, DM AF Brasfield, Sandra M. Talent, Larry G. Janz, David M. TI Reproductive and thyroid hormone profiles in captive Western fence lizards (Sceloporus occidentalis) after a period of brumation SO ZOO BIOLOGY LA English DT Article DE estradiol; testosterone; thyroxine; triiodothyronine; captivity; brumation; reproduction; Sceloporus ID PARASITE PLASMODIUM-MEXICANUM; SICULA-SICULA RAF; SEX STEROIDS; ALLIGATOR-MISSISSIPPIENSIS; TERRITORIAL AGGRESSION; PLASMA TESTOSTERONE; SALMO-GAIRDNERI; RAINBOW-TROUT; FEMALE; CYCLE AB Seasonal fluctuation in serum concentrations of sex steroid (testosterone [T] and 17 beta-estradiol [E-2]) and thyroid (triiodothyronine [T-3] and thyroxine [T-4]) hormones was determined in captive Western fence lizards (Sceloporus occidentalis). Samples were collected from male and female breeding pairs weekly for a 4-month period after their emergence from artificial brumation. Circulating levels of E-2 corresponded with the expected vitellogenic and ovulatory cycles in females, and surprisingly, E-2 in males followed a similar pattern, indicating a possible role in breeding behavior. Serum T was elevated in male lizards for the first 6 weeks after emergence from brumation, possibly related to an increase in the onset of active spermatogenesis. Thyroid hormones showed little cyclical activity throughout the breeding period, with the exception of small increases of T-3 at weeks 8 and 16, possibly implying an active role of this hormone with ovulation in females. Overall, these baseline hormone data are not only useful in developing this animal as a laboratory reptile model for assessment of endocrine-mediated toxicity, but also of value for understanding herpetological endocrinology and for application in the conservation of threatened species. C1 [Brasfield, Sandra M.; Talent, Larry G.; Janz, David M.] Oklahoma State Univ, Dept Zool, Stillwater, OK 74078 USA. RP Brasfield, SM (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM sandra.m.brasfield@erde.usace.army.mil NR 37 TC 11 Z9 12 U1 2 U2 20 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0733-3188 J9 ZOO BIOL JI Zoo Biol. PD JAN-FEB PY 2008 VL 27 IS 1 BP 36 EP 48 DI 10.1002/zoo.20159 PG 13 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 260IF UT WOS:000253003300003 PM 19360602 ER PT J AU Gong, P Guan, X Inouye, LS Deng, YP Pirooznia, M Perkins, EJ AF Gong, Ping Guan, Xin Inouye, Laura S. Deng, Youping Pirooznia, Mehdi Perkins, Edward J. TI Transcriptomic analysis of RDX and TNT interactive sublethal effects in the earthworm Eisenia fetida SO BMC GENOMICS LA English DT Article AB Background: Explosive compounds such as TNT and RDX are recalcitrant contaminants often found co-existing in the environment. In order to understand the joint effects of TNT and RDX on earthworms, an important ecological and bioindicator species at the molecular level, we sampled worms ( Eisenia fetida) exposed singly or jointly to TNT (50 mg/kg soil) and RDX (30 mg/kg soil) for 28 days and profiled gene expression in an interwoven loop designed microarray experiment using a 4k-cDNA array. Lethality, growth and reproductive endpoints were measured. Results: Sublethal doses of TNT and RDX had no significant effects on the survival and growth of earthworms, but significantly reduced cocoon and juvenile counts. The mixture exhibited more pronounced reproductive toxicity than each single compound, suggesting an additive interaction between the two compounds. In comparison with the controls, we identified 321 differentially expressed transcripts in TNT treated worms, 32 in RDX treated worms, and only 6 in mixture treated worms. Of the 329 unique differentially expressed transcripts, 294 were affected only by TNT, 24 were common to both TNT and RDX treatments, and 3 were common to all treatments. The reduced effects on gene expression in the mixture exposure suggest that RDX might interact in an antagonistic manner with TNT at the gene expression level. The disagreement between gene expression and reproduction results may be attributed to sampling time, absence of known reproduction-related genes, and lack of functional information for many differentially expressed transcripts. A gene potentially related to reproduction ( echinonectin) was significantly depressed in TNT or RDX exposed worms and may be linked to reduced fecundity. Conclusions: Sublethal doses of TNT and RDX affected many biological pathways from innate immune response to oogenesis, leading to reduced reproduction without affecting survival and growth. A complex interaction between mixtures of RDX and TNT was observed at the gene expression level that requires further study of the dynamics of gene expression and reproductive activities in E. fetida. These efforts will be essential to gain an understanding of the additive reproductive toxicity between RDX and TNT. C1 [Gong, Ping; Guan, Xin] SpecPro Inc, Vicksburg, MS 39180 USA. [Inouye, Laura S.; Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Deng, Youping; Pirooznia, Mehdi] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. RP Gong, P (reprint author), SpecPro Inc, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ping.gong@us.army.mil; xin.guan@us.army.mil; lino461@ecy.wa.gov; youping.deng@usm.edu; mehdi.pirooznia@usm.edu; edward.j.perkins@us.army.mil OI Pirooznia, Mehdi/0000-0002-4210-6458 NR 26 TC 29 Z9 32 U1 0 U2 11 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PY 2008 VL 9 SU 1 AR S15 DI 10.1186/1471-2164-9-S1-S15 PG 9 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA V92JP UT WOS:000206244100016 PM 18366604 ER PT J AU Pirooznia, M Perkins, EJ Deng, YP AF Pirooznia, Mehdi Perkins, Edward J. Deng, Youping TI Batch Blast Extractor: an automated blastx parser application SO BMC GENOMICS LA English DT Article AB Motivation: BLAST programs are very efficient in finding similarities for sequences. However for large datasets such as ESTs, manual extraction of the information from the batch BLAST output is needed. This can be time consuming, insufficient, and inaccurate. Therefore implementation of a parser application would be extremely useful in extracting information from BLAST outputs. Results: We have developed a java application, Batch Blast Extractor, with a user friendly graphical interface to extract information from BLAST output. The application generates a tab delimited text file that can be easily imported into any statistical package such as Excel or SPSS for further analysis. For each BLAST hit, the program obtains and saves the essential features from the BLAST output file that would allow further analysis. The program was written in Java and therefore is OS independent. It works on both Windows and Linux OS with java 1.4 and higher. It is freely available from: http://mcbc.usm.edu/BatchBlastExtractor/ C1 [Pirooznia, Mehdi; Deng, Youping] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. [Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Deng, YP (reprint author), Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. EM Mehdi.Pirooznia@usm.edu; Edward.J.Perkins@erdc.usace.army.mil; youping.deng@usm.edu OI Pirooznia, Mehdi/0000-0002-4210-6458 NR 7 TC 4 Z9 5 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PY 2008 VL 9 SU 2 AR S10 DI 10.1186/1471-2164-9-S2-S10 PG 5 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA V92JQ UT WOS:000206244200011 PM 18831775 ER PT J AU Kaempfer, TU Hopkins, MA Perovich, DK AF Kaempfer, T. U. Hopkins, M. A. Perovich, D. K. TI A three-dimensional microstructure-based photon-tracking model of radiative transfer in snow SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID NONSPHERICAL ICE PARTICLE; BIDIRECTIONAL REFLECTANCE; ANTARCTIC SNOW; SOLAR-RADIATION; SPECTRAL ALBEDO; ABSORPTION-COEFFICIENTS; ULTRAVIOLET-RADIATION; INDEPENDENT SPHERES; OPTICAL-PROPERTIES; SURFACE ALBEDO AB [1] Solar radiation is a key component of the energy budget of snow-covered landscapes. Even a thin snow cover reflects most of the incident sunlight and transmits little. An understanding of the interaction of solar radiation with snow is essential to the study of the snow thermodynamics, chemistry, hydrology, ecology, and remote sensing. To investigate this interaction, a microstructure-based photon-tracking algorithm is presented. The three-dimensional snow microstructure is provided either by a discrete element model defined by shape, size, and spatial arrangement of individual ice grains or by an X-ray microtomography image of a snowpack. The model uses refraction, Fresnel reflection, and absorption laws, and the only optical input parameters are the complex index of refraction and absorption coefficient. The model follows individual photons through the microstructure, a porous network of ice and air, applying the fundamental optics laws at the ice-air interfaces and within the ice. By firing tens of thousands of photons a detailed examination of the spectral radiance and irradiance above, below, and within the snowpack is possible. The model was compared to results from a discrete ordinates model, and its sensitivity to the microstructural representation was studied. It was applied to investigate changes in reflected, absorbed, and transmitted light as a function of wavelength, snow depth, grain size, and snow density, used to predict the amount and direction of scattering within the snowpack, and used to explore the interaction of a collimated beam with snow. C1 [Kaempfer, T. U.; Hopkins, M. A.; Perovich, D. K.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Kaempfer, TU (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. NR 62 TC 13 Z9 13 U1 0 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD DEC 28 PY 2007 VL 112 IS D24 AR D24113 DI 10.1029/2006JD008239 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 246NM UT WOS:000252013700004 ER PT J AU Pan, YL Pinnick, RG Hill, SC Rosen, JM Chang, RK AF Pan, Yong-Le Pinnick, Ronald G. Hill, Steven C. Rosen, James M. Chang, Richard K. TI Single-particle laser-induced-fluorescence spectra of biological and other organic-carbon aerosols in the atmosphere: Measurements at New Haven, Connecticut, and Las Cruces, New Mexico SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID INDUCED BREAKDOWN SPECTROSCOPY; CONDENSATION-NUCLEI CONCENTRATIONS; ATLANTA SUPERSITE PROJECT; MASS-SPECTROMETRY PALMS; FINE PARTICULATE MATTER; HUMIC-LIKE SUBSTANCES; INTRINSIC FLUORESCENCE; AIRBORNE BACTERIA; FUNGAL SPORES; UNITED-STATES AB [1] This study focuses on organic carbon (OC) aerosols, including natural biological aerosols, in the Earth's troposphere, and on laser-induced fluorescence (LIF) spectral methods for studying these aerosols. LIF spectra of atmospheric OC and biological aerosols (having diameters greater than approximately 3 mu m) measured at New Haven, Connecticut, and Las Cruces, New Mexico, are reported. A hierarchical clustering method was used to cluster approximately 90% of the single-particle LIF spectra into 8-10 groups. Some of these groups have spectra that are similar to spectra of some important classes of atmospheric aerosol, such as humic/ fulvic acids and humic- like substances, bacteria, cellulose, marine aerosol, and polycyclic aromatic hydrocarbons (PAH). A comparison with previous measurements made at Adelphi, Maryland, reveals that the most highly populated clusters found at Adelphi, and some of the less populated ones, also appear in the LIF spectra at New Haven and Las Cruces, even though the regional climates at these locations is different (New England/Atlantic Coastal, for New Haven and Adelphi, and Chihuahuan Desert for Las Cruces), and the measurements were made in different seasons. The results are consistent with some (perhaps most) of the fluorors in OC and biological atmospheric aerosols being common to these three sites. On average, spectra characteristic of humic/fulvic acids and humic-like substances (HULIS) comprise 28-43% of fluorescent particles at all three sites; whereas cellulose-like spectra contribute only 1-3%. C1 [Pan, Yong-Le; Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. [Pinnick, Ronald G.; Hill, Steven C.] USA, Res Lab, Adelphi, MD USA. [Pinnick, Ronald G.; Rosen, James M.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. RP Pan, YL (reprint author), Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. NR 99 TC 36 Z9 36 U1 1 U2 25 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD DEC 28 PY 2007 VL 112 IS D24 AR D24S19 DI 10.1029/2007JD008741 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 246NM UT WOS:000252013700009 ER PT J AU Bhonsle, JB Venugopal, D Huddler, DP Magill, AJ Hicks, RP AF Bhonsle, Jayendra B. Venugopal, Divakaramenon Huddler, Donald P. Magill, Alan J. Hicks, Rickey P. TI Application of 3D-QSAR for identification of descriptors defining bioactivity of antimicrobial peptides SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID PREDICTIVE QSAR MODELS; BIOLOGICAL-ACTIVITY; CELL-WALL; PLS; CONFORMATION AB In our laboratory, a series of antimicrobial peptides have been developed, where the resulting 3D-physicochemical properties are controlled by the placement of amino acids with well-defined properties (hydrophobicity, charge density, electrostatic potential, and so on) at specific locations along the peptide backbone. These peptides exhibited different in vitro activity against Staphylococcus aureus (SA) and, Mycobacterium ranae (MR) bacteria. We hypothesized that the differences in the biological activity is a direct manifestation of different physicochemical interactions that occur between the peptides and the cell membranes of the bacteria. 3D-QSAR analysis has shown that, within this series, specific physicochemical properties are responsible for antibacterial activity and selectivity. There are five physicochemical properties specific to the SA QSAR model, while five properties are specific to the MR QSAR model. These results support the hypothesis that, for any particular AMP, organism selectivity and potency are controlled by the chemical composition of the target cell membrane. C1 [Bhonsle, Jayendra B.; Venugopal, Divakaramenon; Huddler, Donald P.; Magill, Alan J.; Hicks, Rickey P.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Hicks, RP (reprint author), E Carolina Univ, Dept Chem, Sci & Technol Bldg Suite 300, Greenville, NC 27858 USA. EM jayendra.bhonsle@na.amedd.army.mil; hicksr@ecu.edu RI Bhonsle, Jayendra/A-9139-2011 NR 34 TC 33 Z9 34 U1 1 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD DEC 27 PY 2007 VL 50 IS 26 BP 6545 EP 6553 DI 10.1021/jm070884y PG 9 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 244DE UT WOS:000251845400015 PM 18062663 ER PT J AU Moore, EE Knudson, MM Schwab, CW Trunkey, DD Johannigman, JA Holcomb, JB AF Moore, Ernest E. Knudson, M. Margaret Schwab, C. William Trunkey, Donald D. Johannigman, Jay A. Holcomb, John B. TI Military-civilian collaboration in trauma care and the senior visiting surgeon program SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID OPERATION IRAQI FREEDOM; RECOMBINANT-FACTOR-VIIA; COMBAT CASUALTY CARE; US ARMY; UNITED-STATES; EXPERIENCE; TERRORISM; CENTERS; INJURY; THROMBOEMBOLISM C1 Univ Colorado, Denver Hlth Med Ctr, Dept Surg, Denver, CO 80202 USA. Univ Calif San Francisco, San Francisco Gen Hosp, Dept Surg, San Francisco, CA USA. Univ Cincinnati, Dept Surg, Cincinnati, OH 45267 USA. Oregon Hlth & Sci Univ, Dept Surg, Portland, OR USA. Univ Penn, Med Ctr, Dept Surg, Philadelphia, PA 19104 USA. Brooke Army Med Ctr, USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Moore, EE (reprint author), Univ Colorado, Denver Hlth Med Ctr, Dept Surg, Denver, CO 80202 USA. NR 38 TC 26 Z9 27 U1 0 U2 2 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 27 PY 2007 VL 357 IS 26 BP 2723 EP 2727 DI 10.1056/NEJMsr073207 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 245UO UT WOS:000251964500014 PM 18160694 ER PT J AU Bonvicino, A Hultron, S Fadare, O AF Bonvicino, Amanda Hultron, Sonny Fadare, Oluwole TI Papanicolaou test interpretations of "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" SO CANCER CYTOPATHOLOGY LA English DT Article DE colposcopy; CIN2+; Papanicolaou (Pap) test; high-grade squamous intraepithelial lesion; atypical squamous cells; cervix; ASC-H ID ASC-H; FOLLOW-UP; UNDETERMINED SIGNIFICANCE; CLINICAL-SIGNIFICANCE; CYTOLOGIC DIAGNOSIS; CERVICAL CYTOLOGY; BETHESDA SYSTEM; PAP TEST; WOMEN; HSIL AB BACKGROUND. Management guidelines for women with Papanicolaou (Pap) test interpretations of ASC-H (atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion) reflect substantial risk, which ranges from 10% to 68%, of a cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in their follow-up histologic samples. The present study was initiated to determine the number of colposcopic procedures and the time frame that are typically required for a definitive diagnosis of a CIN2+ lesion after a Papanicolaou (Pap) test interpretation of ASC-H in routine practice. METHODS. Clinicopathologic data on consecutive ASC-H interpretations, 97% of which were on liquid-based preparations, were reviewed. The number of biopsies (which was used in this context as a surrogate indicator for the number of colposcopic procedures) as well as the average duration required for a follow-up histologic diagnosis of CIN2+ were determined. RESULTS. Of 500 ASC-H interpretations, 75 were excluded for a variety of reasons and 165 lacked follow-up in our records. The average age and follow-up duration for the remaining 260 patients was 35.6 years and 18.5 months, respectively. CIN2+ was diagnosed in 49 (40%) of the 122 patients with at least 1 histologic follow-up. Of these 49 patients, 72% (35 of 49) were diagnosed on the first follow-up cervical biopsy, 14% (7 of 49) and 8% (4 of 49) were diagnosed on the second and third follow-up biopsies, respectively; in only 6% (3 of 49) was a fourth follow-up biopsy required. Overall, an average of 1.53 biopsies (range, 1-4) was required to attain a definitive diagnosis of CIN2+, and 28% of patients required more than 1 follow-up biopsy. The average period between the index ASC-H interpretations and CIN2+ diagnoses was 5.5 months. The average time to CIN2+ diagnoses by the first follow-up biopsy was 3 months; for diagnoses made on subsequent biopsies, the average additional follow-up duration was 8 months. Of the eventual CIN2+ diagnoses, 84% were rendered within 12 months of their associated index ASC-H interpretations. CONCLUSIONS. 1) A substantial subset-28%-of patients with biopsy-proven CIN2+ after ASC-H interpretations required more than 1 colposcopy for a definitive diagnosis of a high-grade dysplastic lesion. 2) If a CIN2+ lesion is present, the vast majority can be diagnosed in a biopsy performed within 1 year of the ASC-H interpretation. C1 [Bonvicino, Amanda; Hultron, Sonny; Fadare, Oluwole] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX 78236 USA. [Bonvicino, Amanda; Hultron, Sonny] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX USA. [Bonvicino, Amanda; Hultron, Sonny] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, San Antonio, TX USA. [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX USA. RP Fadare, O (reprint author), Wilford Hall USAF Med Ctr, Dept Pathol, 220 Bergquist Dr, Ste 1, Lackland AFB, TX 78236 USA. EM oluwolefadare@yahoo.com NR 30 TC 19 Z9 20 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER CYTOPATHOL JI Cancer Cytopathol. PD DEC 25 PY 2007 VL 111 IS 6 BP 477 EP 481 DI 10.1002/cncr.23121 PG 5 WC Oncology; Pathology SC Oncology; Pathology GA 244TS UT WOS:000251888800004 PM 17932941 ER PT J AU Chakraborti, D Trichy, GR Prater, JT Narayan, J AF Chakraborti, D. Trichy, G. R. Prater, J. T. Narayan, J. TI The effect of oxygen annealing on ZnO : Cu and ZnO :(Cu,Al) diluted magnetic semiconductors SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article ID CO-DOPED ZNO; ROOM-TEMPERATURE FERROMAGNETISM; THIN-FILMS; OXIDES; VACANCIES AB Here we report a systematic study of magnetic, electronic and microstructural properties of Cu-doped and Cu and Al codoped ZnO thin films, grown epitaxially on a (0001) sapphire substrate by the pulsed laser deposition technique. The films were annealed in oxygen at high temperature (600 degrees C) and their properties were compared with the as deposited films in order to study the role of defects like oxygen vacancies on the ferromagnetic properties. The doping of ZnO : Cu specimens with Al increased the carrier concentration by three orders of magnitude (from 10(17) to 10(20) cm(-3)) without altering the ferromagnetic ordering. On the other hand, a reduction in oxygen vacancies concentration brought about by high temperature annealing in oxygen had a large detrimental effect on ferromagnetism. These results tend to eliminate a free carrier mediated mechanism and point towards a defect mediated mechanism, such as a bound-magnetic-polaron mediated exchange, as being responsible for stabilizing long-range ferromagnetic ordering in these systems. C1 [Chakraborti, D.; Trichy, G. R.; Prater, J. T.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] Div Mat Sci, Army Res Off, Res Triangle Pk, NC 27709 USA. RP Chakraborti, D (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. RI Narayan, Jagdish/D-1874-2009 NR 39 TC 43 Z9 45 U1 0 U2 20 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0022-3727 EI 1361-6463 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD DEC 21 PY 2007 VL 40 IS 24 BP 7606 EP 7613 DI 10.1088/0022-3727/40/24/002 PG 8 WC Physics, Applied SC Physics GA 243LK UT WOS:000251798100003 ER PT J AU Koziol, K Vilatela, J Moisala, A Motta, M Cunniff, P Sennett, M Windle, A AF Koziol, Krzysztof Vilatela, Juan Moisala, Anna Motta, Marcelo Cunniff, Philip Sennett, Michael Windle, Alan TI High-performance carbon nanotube fiber SO SCIENCE LA English DT Article ID MODULUS POLYETHYLENE FIBERS; STRENGTH; ARRAYS; YARNS AB With their impressive individual properties, carbon nanotubes should form high-performance fibers. We explored the roles of nanotube length and structure, fiber density, and nanotube orientation in achieving optimum mechanical properties. We found that carbon nanotube fiber, spun directly and continuously from gas phase as an aerogel, combines high strength and high stiffness ( axial elastic modulus), with an energy to breakage ( toughness) considerably greater than that of any commercial high- strength fiber. Different levels of carbon nanotube orientation, fiber density, and mechanical properties can be achieved by drawing the aerogel at various winding rates. The mechanical data obtained demonstrate the considerable potential of carbon nanotube assemblies in the quest for maximal mechanical performance. The statistical aspects of the mechanical data reveal the deleterious effect of defects and indicate strategies for future work. C1 Univ Cambridge, Dept Mat Sci, Cambridge CB2 3QZ, England. USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Windle, A (reprint author), Univ Cambridge, Dept Mat Sci, Pembroke St, Cambridge CB2 3QZ, England. EM ahw1@hermes.cam.ac.uk RI Koziol, Krzysztof/E-3626-2010; Vilatela, Juan/E-2418-2012 OI Koziol, Krzysztof/0000-0002-8360-1121; NR 23 TC 467 Z9 478 U1 36 U2 338 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD DEC 21 PY 2007 VL 318 IS 5858 BP 1892 EP 1895 DI 10.1126/science.1147635 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 243HE UT WOS:000251786600050 PM 18006708 ER PT J AU Kaempfer, TU Schneebeli, M AF Kaempfer, T. U. Schneebeli, M. TI Observation of isothermal metamorphism of new snow and interpretation as a sintering process SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID SURFACE-AREA; DRY SNOW; GRAIN-GROWTH; ICE; EVOLUTION; DENSIFICATION; IMAGES; COVER; MODEL AB Isothermal snow metamorphism is based on the fundamental process of sintering. However, the relative weights of the physical processes responsible for sintering between ice grains are still debated. The most active are expected to be grain boundary diffusion or sublimation-condensation. We performed four isothermal experiments, starting with fresh snow, at temperatures of -1.6, -8.3, -19.1, and -54 degrees C during nearly 1 year. Monthly, we imaged the snow samples by X-ray microtomography. We monitored the changes in density, specific surface area, structure model index, and several structural parameters based on the distance transform of the ice matrix and pore space in the snow, as the trabecular number and thickness. At -54 degrees C, the metamorphism process was very slow, and during 1 year the specific surface area decreased by only 19%. For the other samples, the results can be interpreted as a two-stage process with a first phase of rapid change in trabecular number and structure model index and a second phase where the trabecular number and structure model index were constant. An increase in density and trabecular thickness together with a decrease of the specific surface area following a power law were observed throughout the experiments. The increase in ice thickness ( coarsening) related linearly to the densification. The continuous densification implies that volume processes like grain boundary diffusion have to occur. The linear relation between densification and coarsening suggests that the same mechanism governs both processes. The logarithmic decrease of the specific surface area is an indication that the coarsening is rate limiting. C1 [Kaempfer, T. U.; Schneebeli, M.] WSL Swiss Fed Inst Snow & Avalanche Res, Davos, Switzerland. [Kaempfer, T. U.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Kaempfer, TU (reprint author), WSL Swiss Fed Inst Snow & Avalanche Res, Davos, Switzerland. RI Schneebeli, Martin/B-1063-2008 OI Schneebeli, Martin/0000-0003-2872-4409 NR 36 TC 45 Z9 45 U1 2 U2 16 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD DEC 20 PY 2007 VL 112 IS D24 AR D24101 DI 10.1029/2007JD009047 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 244PS UT WOS:000251878400008 ER PT J AU Helegbe, GK Goka, BQ Al Kurtzhals, J Addae, MM Ollaga, E Tetteh, JKA Dodoo, D Ofori, MF Obeng-Adejei, G Hirayama, K Awandare, GA Akanmori, BD AF Helegbe, Gideon K. Goka, Bamenla Q. Al Kurtzhals, Joergen Addae, Michael M. Ollaga, Edwin Tetteh, John K. A. Dodoo, Daniel Ofori, Michael F. Obeng-Adejei, George Hirayama, Kenji Awandare, Gordon A. Akanmori, Bartholomew D. TI Complement activation in Ghanaian children with severe Plasmodium falciparum malaria SO MALARIA JOURNAL LA English DT Article ID REGULATORY PROTEINS; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; INDUCED HEMOLYSIS; GAMBIAN CHILDREN; RENAL-FAILURE; ANEMIA; IMMUNE; ERYTHROCYTES AB Background: Severe anaemia (SA), intravascular haemolysis (IVH) and respiratory distress (RD) are severe forms of Plasmodium falciparum malaria, with RD reported to be of prognostic importance in African children with malarial anaemia. Complement factors have been implicated in the mechanism leading to excess anaemia in acute P. falciparum infection. Methods: The direct Coombs test (DCT) and flow cytometry were used to investigate the mean levels of RBC-bound complement fragments (C3d and C3b alpha beta) and the regulatory proteins [complement receptor 1 (CD35) and decay accelerating factor (CD55)] in children with discrete clinical forms of P. falciparum malaria. The relationship between the findings and clinical parameters including coma, haemoglobin (Hb) levels and RD were investigated. Results: Of the 484 samples tested, 131(27%) were positive in DCT, out of which 115/131 (87.8%) were positive for C3d alone while 16/131 (12.2%) were positive for either IgG alone or both. 67.4% of the study population were below 5 years of age and DCT positivity was more common in this age group relative to children who were 5 years or older (Odds ratio, OR = 3.8; 95% CI, 2.2-6.7, p < 0.001). DCT correlated significantly with RD (beta = - 304, p = 0.006), but multiple regression analysis revealed that, Hb (beta = -0.341, p = 0.012) and coma (beta = -0.256, p = 0.034) were stronger predictors of RD than DCT (beta = 0.228, p = 0.061). DCT was also not associated with IVH, p = 0.19, while spleen size was inversely correlated with Hb (r = -402, p = 0.001). Flow cytometry showed similar mean fluorescent intensity (MFI) values of CD35, CD55 and C3b alpha beta levels on the surfaces of RBC in patients and asymptomatic controls (AC). However, binding of C3b alpha beta correlated significantly with CD35 or CD55 (p < 0.001). Conclusion: These results suggest that complement activation contributed to anaemia in acute childhood P. falciparum malaria, possibly through induction of erythrophagocytosis and haemolysis. In contrast to other studies, this study did not find association between levels of the complement regulatory proteins, CD35 and CD55 and malarial anaemia. These findings suggest that complement activation could also be involved in the pathogenesis of RD but larger studies are needed to confirm this finding. C1 [Helegbe, Gideon K.; Addae, Michael M.; Tetteh, John K. A.; Dodoo, Daniel; Ofori, Michael F.; Akanmori, Bartholomew D.] Univ Ghana, Coll Hlth Sci, NMIMR, Dept Immunol, Legon, Ghana. [Helegbe, Gideon K.] UDS, SMHS, Dept Biochem & Mol Med, Tamale, Ghana. [Goka, Bamenla Q.; Obeng-Adejei, George] Korle Bu Teaching Hosp, Dept Child Hlth, Accra, Ghana. [Al Kurtzhals, Joergen] Copenhagen Univ Hosp, Dept Clin Microbiol, Ctr Med Parasitol, Righosp, Copenhagen, Denmark. [Ollaga, Edwin] Korle Bu Teaching Hosp, Blood Bank, Accra, Ghana. [Helegbe, Gideon K.; Hirayama, Kenji] Nagasaki Univ, Inst Trop Med, Dept Immunogenet, NEKKEN, Nagasaki, Japan. [Awandare, Gordon A.] Univ Ghana, Dept Biochem, Legon, Ghana. [Awandare, Gordon A.] Walter Reed Army Inst Res, Dept Cellular Injury, Div Mil Casualty Res, Silver Spring, MD USA. RP Akanmori, BD (reprint author), Univ Ghana, Coll Hlth Sci, NMIMR, Dept Immunol, Legon, Ghana. EM kofigidi@yahoo.com; bamenla@yahoo.co.uk; joergen.kurtzhals@rh.regionh.dk; maddae@excite.com; maddae@excite.com; jtetteh@noguchi.mimcom.net; ddodoo@noguchi.mimcom.net; mofori@noguchi.mimcom.net; goadjei@yahoo.com; hiraken@nagasaki-u.ac.jp; gordon.awandare@us.army.mil; bakanmori@noguchi.mimcom.net OI Hirayama, Kenji/0000-0001-9467-1777; Kurtzhals, Jorgen/0000-0003-2760-8713; Awandare, Gordon/0000-0002-8793-3641 NR 41 TC 16 Z9 16 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 17 PY 2007 VL 6 AR 165 DI 10.1186/1475-2875-6-165 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 260GQ UT WOS:000252999200002 PM 18086298 ER PT J AU Richmond, A Kaufmann, RK Myneni, RB AF Richmond, Amy Kaufmann, Robert K. Myneni, Ranga B. TI Valuing ecosystem services: A shadow price for net primary production SO ECOLOGICAL ECONOMICS LA English DT Article DE ecosystem valuation; net primary production; ecosystem services ID MANGROVE-FISHERY LINKAGES; GLOBAL PATTERNS; BIODIVERSITY; PERSPECTIVE; ENVIRONMENT; ECOLOGY; VALUES; INDEX; TESTS; MODEL AB We analyze the contribution of ecosystem services to GDP and use this contribution to calculate an empirical price for ecosystem services. Net primary production is used as a proxy for ecosystem services and, along with capital and labor, is used to estimate a Cobb Douglas production function from an international panel. A positive output elasticity for net primary production probably measures both marketed and nonmarketed contributions of ecosystems services. The production function is used to calculate the marginal product of net primary production, which is the shadow price for ecosystem services. The shadow price generally is greatest for developed nations, which have larger technical scalars and use less net primary production per unit output. The rate of technical substitution indicates that the quantity of capital needed to replace a unit of net primary production tends to increase with economic development, and this rate of replacement may ultimately constrain economic growth. Published by Elsevier B.V. C1 [Richmond, Amy] W Point Mil Acad, Dept Geog & Environm Engn, West Point, NY 12518 USA. [Kaufmann, Robert K.; Myneni, Ranga B.] Boston Univ, Dept Geog & Environm, Boston, MA 02215 USA. [Kaufmann, Robert K.] Boston Univ, Ctr Energy & Environm Studies, Boston, MA 02215 USA. RP Richmond, A (reprint author), W Point Mil Acad, Dept Geog & Environm Engn, West Point, NY 12518 USA. EM amy.richmond@usma.edu RI Myneni, Ranga/F-5129-2012; OI Richmond, Amy/0000-0002-9045-537X NR 36 TC 31 Z9 39 U1 4 U2 35 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8009 J9 ECOL ECON JI Ecol. Econ. PD DEC 15 PY 2007 VL 64 IS 2 BP 454 EP 462 DI 10.1016/j.ecolecon.2007.03.009 PG 9 WC Ecology; Economics; Environmental Sciences; Environmental Studies SC Environmental Sciences & Ecology; Business & Economics GA 249XT UT WOS:000252264600021 ER PT J AU Can, E La Scala, JJ Sands, JM Palmese, GR AF Can, E. La Scala, J. J. Sands, J. M. Palmese, G. R. TI The synthesis of 9-10 dibromo stearic acid glycidyl methacrylate and its use in vinyl ester resins SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE resins; flame retardance; halogenated; monomers; thermal properties AB In this study, 9-10 dibromo stearic acid glycidyl methacrylate (Di-BrSAGMA) was synthesized from oleic acid and used as a replacement for styrene in vinyl ester (bisphenol A type VE (VE 828) and Novalac type VE (VE160)) to introduce fire retardance to these systems and to decrease the volatile organic compound (VOC emissions caused by styrene. When the Di-BrSAGMA was used as the comonomer, these resins exhibited too high viscosities, reduced modulus and glass transition temperature (T-g) values compared to those of the styrene based systems. Thus, the Di-BrSAGNIA was used in the presence of styrene in these resins. The viscosities of the resins with various Di-BrSAGMA contents were determined and the modulus and the T-g values of the resulting polymers were measured via dynamic mechanical analysis (DMA) to determine the ideal formulations for each resin system. Similar analysis was performed, with similar oleic acid glycidyl methacrylate (OAGMA) contents, to determine the effect of the introduction of the bromine groups onto the network. Reactive diluent blends of the fatty acid based monomers with styrene, at styrene contents as low as 15-20 wt % at 35-45 wt % total comonomer content, in VE formulations were shown to have processable viscosities for liquid molding processes, and modulus and T, values that are comparable to those of the commercial VE-styrene systems. The effect of the replacement of styrene by the Di-BrSAGMA monomer on the thermal degradation behavior of the VE 828 and VE 160 networks was also explored by thermal gravimetric analysis (TGA). C1 Drexel Univ, Dept Biol & Chem Engn, Philadelphia, PA 19104 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Palmese, GR (reprint author), Drexel Univ, Dept Biol & Chem Engn, Philadelphia, PA 19104 USA. EM palmese@coe.drexel.edu NR 12 TC 7 Z9 8 U1 4 U2 15 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD DEC 15 PY 2007 VL 106 IS 6 BP 3833 EP 3842 DI 10.1002/app.26249 PG 10 WC Polymer Science SC Polymer Science GA 226RW UT WOS:000250607200035 ER PT J AU Lehman, RA Sasso, RC Helgeson, MD Dmitriev, AE Gill, NW Rosner, MR Riew, KD AF Lehman, Ronald A., Jr. Sasso, Rick C. Helgeson, Melvin D. Dmitriev, Anton E. Gill, Norman W. Rosner, Michael R. Riew, K. Daniel TI Accuracy of intraoperative plain radiographs to detect violations of intralaminar screws placed into the C2 vertebrae - A reliability study SO SPINE LA English DT Article DE intralaminar screw; atlantoaxial fixation; axis; intraoperative radiographs; atlantoaxial instability; translaminar screw ID ATLANTOAXIAL FIXATION; TECHNICAL NOTE; C1-C2 FUSION; POSTERIOR; ARTHRODESIS; PEDICLE AB Study Design. Cadaveric radiographic interpretation analysis. Objective. To evaluate the reliability of plain radiographs for detecting potentially serious C2 ventral laminar violations during insertion of intralaminar screws. Summary of Background Data. With the potential serious complications (due to aberrant course of the vertebral artery) associated with insertion of C1-C2 transarticular screws, coupled with inherent difficulties with inserting either C2 pedicle or pars/isthmus screws, the intralaminar technique has recently gained popularity. Methods. After visually confirming that we had placed bilateral screws entirely in the lamina in 12 cadaveric specimens, we obtained lateral radiographs, We repeated the screw insertions and radiographs for each of the following permutations: right in/left out, left in/right out, and both screws out. Three experienced spine surgeons blindly/independently assessed all 48 radiographs 3 times. A screw projecting into the lateral mass was read as having perforated the ventral lamina. Accuracy was defined as percent agreement between actual and read position for 288 screws (48 L, 48 R times 3 raters). Results. Accuracy was 77.4%. The highest accuracy was with both screws in (86.1%); the lowest with both out (63.9%). Left in-right out was 77.8%. Right in-left out was 81.9%. There was significantly higher incorrect identification of both out (rated "both in" in all but one; chi(2) = 11.5, P < 0.05). Interrater reliability was moderate (k = 0.42) and sufficient for clinical use. Intrarater reliability was excellent for all three (k = 0.98, 1.00, 0.93). Conclusion. With both screws out, the accuracy was only 63.9%, suggesting that in over 36% of bilateral screw perforations, plain radiographs cannot detect the violation. While some of these might not cause clinical symptoms, others might cause subtle radiculopathy, myelopathy, or headaches. The presence of any of these should be worked up with a postoperative CT scan, as plain radiographs are not dependable. C1 [Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC USA. [Sasso, Rick C.] Indiana Univ, Sch Med, Indiana Spine Grp, Indianapolis, IN USA. [Helgeson, Melvin D.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC USA. [Dmitriev, Anton E.; Gill, Norman W.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Spine Res Lab, Washington, DC USA. [Rosner, Michael R.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC USA. [Riew, K. Daniel] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO 63130 USA. RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, 1528 Blue Meadow Rd, Potomac, MD 20854 USA. EM armyspine@yahoo.com NR 16 TC 9 Z9 10 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD DEC 15 PY 2007 VL 32 IS 26 BP 3036 EP 3040 PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 242AL UT WOS:000251696800025 PM 18091498 ER PT J AU Zander, NE Orticki, JA Karikari, AS Long, TE Rawlett, AM AF Zander, Nicole E. Orticki, Joshua A. Karikari, Afia S. Long, Timothy E. Rawlett, Adam M. TI Super-hydrophobic surfaces via micrometer-scale templated pillars SO CHEMISTRY OF MATERIALS LA English DT Article ID SELF-DIFFUSION; BREATH FIGURES; POLYMER-FILMS; DRY; WATER AB The fabrication of enhanced hydrophobic surfaces via simple and inexpensive means will be discussed. Regular arrays of microscale pores were prepared in polymer matrices via the spontaneous assembly of water-vapor condensation, the so-called breath figure method. Using these regular arrays of pores as templates, the analogous array of pillars (inverse pores) was transferred to polymeric films. These microtextured surfaces have greatly enhanced the hydrophobicity of the polymer when measured by the contact angle. This method of producing super-hydrophobic textured surfaces should be amenable to high-throughput, low-cost manufacturing of many polymeric surfaces. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Virginia Polytech Inst & State Univ, Macromol & Interfaces Inst, Dept Chem, Blacksburg, VA 24061 USA. RP Rawlett, AM (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM arawlett@arl.army.mil NR 21 TC 36 Z9 38 U1 1 U2 34 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD DEC 11 PY 2007 VL 19 IS 25 BP 6145 EP 6149 DI 10.1021/cm0715895 PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 238BJ UT WOS:000251422000017 ER PT J AU Costanzo, PJ Beyer, FL AF Costanzo, Philip J. Beyer, Frederick L. TI Thermoresponsive, optically active films based on Diels-Alder chemistry SO CHEMISTRY OF MATERIALS LA English DT Article ID BLOCK-COPOLYMERS; POLYMER; NANOCOMPOSITES; NANOPARTICLES; BLENDS; LAYERS AB Reversible Diels-Alder chemistry was exploited to develop polymer films in which a change in optical clarity can be thermally triggered. SiO2 nanoparticles of various sizes were functionalized with maleimido moieties. A furyl-terminated poly(ethylene glycol) linker was prepared and tethered to the SiO2, nanoparticles via a Diels-Alder (DA) linkage. The pegylated SiO2 nanoparticles were randomly distributed within a poly(methyl methacrylate) (PMMA) matrix, resulting in an optically transparent film. Annealing the film cleaves the DA linkage and effectively renders the SiO2 particles immiscible within the PMMA matrix creating a driving force for particle aggregation. The large aggregates were able to scatter light and resulted in an optically opaque film. C1 USA, Res Lab, Div Mat, Attn AMSRD ARL WM MA, Aberdeen Proving Ground, MD 21005 USA. RP Beyer, FL (reprint author), USA, Res Lab, Div Mat, Attn AMSRD ARL WM MA, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM flbeyer@arl.army.mil RI Costanzo, Philip/E-8879-2011 OI Costanzo, Philip/0000-0001-6220-463X NR 22 TC 14 Z9 14 U1 1 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD DEC 11 PY 2007 VL 19 IS 25 BP 6168 EP 6173 DI 10.1021/cm701864r PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 238BJ UT WOS:000251422000020 ER PT J AU Apperson, S Shende, RV Subramanian, S Tappmeyer, D Gangopadhyay, S Chen, Z Gangopadhyay, K Redner, P Nicholich, S Kapoor, D AF Apperson, S. Shende, R. V. Subramanian, S. Tappmeyer, D. Gangopadhyay, S. Chen, Z. Gangopadhyay, K. Redner, P. Nicholich, S. Kapoor, D. TI Generation of fast propagating combustion and shock waves with copper oxide/aluminum nanothermite composites SO APPLIED PHYSICS LETTERS LA English DT Article AB Nanothermite composites containing metallic fuel and inorganic oxidizer are gaining importance due to their outstanding combustion characteristics. In this paper, the combustion behaviors of copper oxide/aluminum nanothermites are discussed. CuO nanorods were synthesized using the surfactant-templating method, then mixed or self-assembled with Al nanoparticles. This nanoscale mixing resulted in a large interfacial contact area between fuel and oxidizer. As a result, the reaction of the low density nanothermite composite leads to a fast propagating combustion, generating shock waves with Mach numbers up to 3. (C) 2007 American Institute of Physics. C1 [Apperson, S.; Shende, R. V.; Subramanian, S.; Tappmeyer, D.; Gangopadhyay, S.] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Chen, Z.] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. [Gangopadhyay, K.] Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. [Redner, P.; Nicholich, S.; Kapoor, D.] ARDEC, US Army, Piscatiny, NJ 07896 USA. RP Apperson, S (reprint author), Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. EM sja895@mizzou.edu; gangopadhyay@missouri.edu NR 19 TC 60 Z9 62 U1 1 U2 18 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 10 PY 2007 VL 91 IS 24 AR 243109 DI 10.1063/1.2787972 PG 3 WC Physics, Applied SC Physics GA 241TM UT WOS:000251678700063 ER PT J AU Yu, M Malvankar, A Su, W Foo, SY AF Yu, Ming Malvankar, Aniket Su, Wei Foo, Simon Y. TI A link availability-based QoS-aware routing protocol for mobile ad hoc sensor networks SO COMPUTER COMMUNICATIONS LA English DT Article DE mobility; routing; QoS; ad hoc network; sensor AB With more and more wireless devices being mobile, there is a constant challenge to provide reliable and high quality communication services among these devices. In this paper, we propose a link availability-based QoS-aware (LABQ) routing protocol for mobile ad hoc networks based on mobility prediction and link quality measurement, in addition to energy consumption estimate. The goal is to provide highly reliable and better communication links with energy-efficiency. The proposed routing algorithm has been verified by NS-2 simulations. The results have shown that LABQ outperforms existing algorithms by significantly reducing link breakages and thereby reducing the overheads in reconnection and retransmission. It also reduces the average end-to-end delay for data transfer and enhances the lifetime of nodes by making energy-efficient routing decisions. (C) 2007 Elsevier B.V. All rights reserved. C1 [Yu, Ming; Malvankar, Aniket; Foo, Simon Y.] FSU Coll Engn, FAMU, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. [Su, Wei] USA, CERDEC, Ft Monmouth, NJ 07703 USA. RP Yu, M (reprint author), FSU Coll Engn, FAMU, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. EM mingyu@eng.fsu.edu NR 30 TC 16 Z9 22 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0140-3664 EI 1873-703X J9 COMPUT COMMUN JI Comput. Commun. PD DEC 10 PY 2007 VL 30 IS 18 BP 3823 EP 3831 DI 10.1016/j.comcom.2007.09.009 PG 9 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 253QW UT WOS:000252533700032 ER PT J AU Trichy, GR Chakraborti, D Narayan, J Prater, JT AF Trichy, G. R. Chakraborti, D. Narayan, J. Prater, J. T. TI Epitaxial FePt thin films and nanodots integrated with Si (1 0 0) SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article AB We present findings on the synthesis and processing of various FePt nanostructures using pulsed laser deposition. FePt was deposited as (a) continuous thin films, (b) single layered nanodots and (c) multi-layered nanodots. Integration of these FePt nanostructures with Si (1 0 0) was achieved by using epitaxial TiN as a template buffer layer. Epitaxy and L1(0) order in the FePt structures were investigated in detail by x-ray diffraction and transmission electron microscopy techniques. Remarkably, we achieved < 0 0 1 > c-axis growth orientation and L1(0) ordering at a low processing temperature of 500 degrees C. The following epitaxial relationship was obtained in the FePt structures: FePt (0 0 1) < 0 0 1 > vertical bar vertical bar TiN (1 0 0) < 0 0 1 > vertical bar vertical bar Si (1 0 0) < 0 0 1 >. The 9.5% misfit strain between FePt and TiN is relaxed by domain matching epitaxy where 10/19 and 11/10 domains alternate across the interface. The composition of the nanostructures was determined by Rutherford backscattering and was found to be Fe(41)Pt(59). The magnetic properties of each of the three nanostructured systems were studied individually and then compared to evaluate them as potential information storage media. Room temperature perpendicular coercivity of 3200 Oe for the single layered FePt nanodot sample was much improved when compared with the continuous epitaxial FePt film sample showing a coercivity of 2250 Oe. In the FePt nanodot system, each nanodot acts as a single domain and assuming one bit of information is stored in each nanodot, magnetic storage density can exceed one terabit per square inch, corresponding to 250 million pages of information per chip. C1 [Trichy, G. R.; Chakraborti, D.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. RP Trichy, GR (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. NR 0 TC 4 Z9 4 U1 1 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0022-3727 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD DEC 7 PY 2007 VL 40 IS 23 BP 7273 EP 7280 DI 10.1088/0022-3727/40/23/003 PG 8 WC Physics, Applied SC Physics GA 243LJ UT WOS:000251797900013 ER PT J AU Smith, TJ Hill, KK Foley, BT Detter, JC Munk, AC Bruce, DC Doggett, NA Smith, LA Marks, JD Xie, G Brettin, TS AF Smith, Theresa J. Hill, Karen K. Foley, Brian T. Detter, John C. Munk, A. Christine Bruce, David C. Doggett, Norman A. Smith, Leonard A. Marks, James D. Xie, Gary Brettin, Thomas S. TI Analysis of the Neurotoxin Complex Genes in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, BoNT/Ba4 and BoNT/B1 Clusters Are Located within Plasmids SO PLOS ONE LA English DT Article AB Background. Clostridium botulinum and related clostridial species express extremely potent neurotoxins known as botulinum neurotoxins (BoNTs) that cause long-lasting, potentially fatal intoxications in humans and other mammals. The amino acid variation within the BoNT is used to categorize the species into seven immunologically distinct BoNT serotypes (A-G) which are further divided into subtypes. The BoNTs are located within two generally conserved gene arrangements known as botulinum progenitor complexes which encode toxin-associated proteins involved in toxin stability and expression. Methodology/Principal Findings. Because serotype A and B strains are responsible for the vast majority of human botulism cases worldwide, the location, arrangement and sequences of genes from eight different toxin complexes representing four different BoNT/A subtypes (BoNT/A1-Ba4) and one BoNT/B1 strain were examined. The bivalent Ba4 strain contained both the BoNT/A4 and BoNT/bvB toxin clusters. The arrangements of the BoNT/A3 and BoNT/A4 subtypes differed from the BoNT/A1 strains and were similar to those of BoNT/A2. However, unlike the BoNT/A2 subtype, the toxin complex genes of BoNT/A3 and BoNT/A4 were found within large plasmids and not within the chromosome. In the Ba4 strain, both BoNT toxin clusters (A4 and bivalent B) were located within the same 270 kb plasmid, separated by 97 kb. Complete genomic sequencing of the BoNT/B1 strain also revealed that its toxin complex genes were located within a 149 kb plasmid and the BoNT/A3 complex is within a 267 kb plasmid. Conclusions/Significance. Despite their size differences and the BoNT genes they contain, the three plasmids containing these toxin cluster genes share significant sequence identity. The presence of partial insertion sequence ( IS) elements, evidence of recombination/gene duplication events, and the discovery of the BoNT/A3, BoNT/Ba4 and BoNT/B1 toxin complex genes within plasmids illustrate the different mechanisms by which these genes move among diverse genetic backgrounds of C. botulinum. C1 [Hill, Karen K.; Detter, John C.; Munk, A. Christine; Bruce, David C.; Doggett, Norman A.; Xie, Gary; Brettin, Thomas S.] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Smith, Theresa J.; Smith, Leonard A.] USA, Med Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA. [Foley, Brian T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA. [Marks, James D.] Univ Calif San Francisco, Dept Anesthesia & Pharmaceut Chem, San Francisco, CA 94143 USA. RP Hill, KK (reprint author), Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. EM Khill@lanl.gov OI xie, gary/0000-0002-9176-924X FU U.S. Department of Energy; NIAID [UO1 AI056493, U01 AI056493]; Intelligence Technology Innovation Center (ITIC); DoD [DAMD17-03-C-0076] FX Funding for this project was provided by the U.S. Department of Energy, and NIAID grant UO1 AI056493. The DOE Joint Genome Institute (JGI) at Los Alamos National Laboratory acknowledges the support of the Intelligence Technology Innovation Center (ITIC) for this research. This work was partially supported by DoD contract DAMD17-03-C-0076 and by NIAID cooperative agreement U01 AI056493. NR 62 TC 87 Z9 949 U1 6 U2 36 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 5 PY 2007 VL 2 IS 12 AR e1271 DI 10.1371/journal.pone.0001271 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA V10JD UT WOS:000207459400018 PM 18060065 ER PT J AU Eckart, RE Shry, EA Atwood, JE Brundage, JE Lay, JC Bateson, TF Grabensteind, JD AF Eckart, Robert E. Shry, Eric A. Atwood, J. Edwin Brundage, John E. Lay, Jenny C. Bateson, Thomas F. Grabensteind, John D. TI Smallpox vaccination and ischemic coronary events in healthy adults SO VACCINE LA English DT Article DE smallpox vaccination; coronary artery disease; acute coronary syndrome; angina; myocardial infarction; vaccinia virus ID UNITED-STATES; COMPLICATIONS; SURVEILLANCE AB Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events. Published by Elsevier Ltd. C1 [Eckart, Robert E.; Shry, Eric A.] Brooke Army Med Ctr, Serv Cardiol MCHE MDC, San Antonio, TX 78234 USA. [Atwood, J. Edwin] Walter Reed Army Med Ctr, Washington, DC USA. [Brundage, John E.; Lay, Jenny C.; Bateson, Thomas F.] Army Med Surveillance Activ, Washington, DC USA. [Grabensteind, John D.] US Army Med Command, Mil Vaccine Agcy, Falls Church, VA USA. RP Eckart, RE (reprint author), Brooke Army Med Ctr, Serv Cardiol MCHE MDC, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM robert.eckart@amedd.anny.mil NR 19 TC 10 Z9 11 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 5 PY 2007 VL 25 IS 50 BP 8359 EP 8364 DI 10.1016/j.vaccine.2007.09.064 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 247KX UT WOS:000252079000003 PM 17981378 ER PT J AU Glinka, YD Tolk, NH Liu, X Sasaki, Y Furdyna, JK AF Glinka, Y. D. Tolk, N. H. Liu, X. Sasaki, Y. Furdyna, J. K. TI Spatially resolved pump-probe second harmonic generation study of multilayer semiconductor heterostructures SO APPLIED PHYSICS LETTERS LA English DT Article ID QUANTUM-WELLS; GAAS AB The transient electric-field-induced second harmonic generation change (TEFISHGC) signals from GaAs/GaSb/InAs heterostructures measured in pump-probe configuration have been applied to monitor the interfacial electric fields arising from the charge separation of pump-induced carriers at the interfaces. The total intensity of the TEFISHGC signal is determined by the interference of contributions from both of the heterointerfaces. By changing the photon energy of the laser light over the GaAs absorption edge, the depth spatial resolution can be achieved allowing the ultrafast dynamics of interfacial electric field at each of the interfaces to be monitored separately. C1 US Army Aviat, Missile RDEC, Redstone Arsenal, AL 35809 USA. Vanderbilt Univ, Dept Phys & Astron, Nashville, TN 37235 USA. Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA. RP Glinka, YD (reprint author), US Army Aviat, Missile RDEC, Redstone Arsenal, AL 35809 USA. EM glinkay@uah.edu NR 12 TC 6 Z9 6 U1 2 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 3 PY 2007 VL 91 IS 23 AR 231104 DI 10.1063/1.2821120 PG 3 WC Physics, Applied SC Physics GA 238MA UT WOS:000251450600004 ER PT J AU Louisirirotchanakul, S Sutthent, R Wasi, C Chuenchitra, T Nitayaphan, S Brown, AE Polonis, VR Nakayama, EE Shioda, T Liu, HL Takebe, Y AF Louisirirotchanakul, Suda Sutthent, Ruengpung Wasi, Chantapong Chuenchitra, Thippawan Nitayaphan, Sorachai Brown, Arthur E. Polonis, Victoria R. Nakayama, Emi E. Shioda, Tatsuo Liu, Huanliang Takebe, Yutaka TI Host genetic analysis of HIV type 1 subtype CRF01_AE (E)-infected Thai patients with different rates of disease progression SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Letter ID POLYMORPHISM; AIDS; CCR5-DELTA-32; INFECTION; ALLELES C1 [Louisirirotchanakul, Suda; Sutthent, Ruengpung; Wasi, Chantapong] Mahidol Univ, Fac Med, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand. [Chuenchitra, Thippawan; Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Brown, Arthur E.] US Army Med Mat Dev Act, Ft Detrick, MD USA. [Polonis, Victoria R.] Walter Reed Army Inst Res, Rockville, MD USA. [Nakayama, Emi E.; Shioda, Tatsuo] Osaka Univ, Res Inst Microbial Dis, Dept Viral Infect, Osaka, Japan. [Liu, Huanliang] Univ Miami, Miller Sch Med, Miami, FL 33152 USA. [Takebe, Yutaka] NIID, AIDS Res Ctr, Tokyo, Japan. RP Louisirirotchanakul, S (reprint author), Mahidol Univ, Fac Med, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand. EM sudaloui@yahoo.com OI Liu, Huanliang/0000-0002-1006-6666 NR 15 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD DEC PY 2007 VL 23 IS 12 BP 1605 EP 1607 DI 10.1089/aid.2007.0101 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 246PL UT WOS:000252019200021 PM 18160021 ER PT J AU Wisco, OJ Sloan, SB Johnson, RP AF Wisco, Oliver J. Sloan, Steven B. Johnson, Ryan P. TI Erythematous annular lesions SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material ID CUTANEOUS LUPUS-ERYTHEMATOSUS C1 [Wisco, Oliver J.; Sloan, Steven B.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Johnson, Ryan P.] Ohio State Univ, Coll Med & Publ Hlth, Columbus, OH 43210 USA. RP Wisco, OJ (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM oliver.wisco@amedd.army-mil NR 6 TC 0 Z9 0 U1 1 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD DEC 1 PY 2007 VL 76 IS 11 BP 1709 EP 1710 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 240QA UT WOS:000251600900015 PM 18092713 ER PT J AU Taylor, AJ AF Taylor, Allen J. TI Finding the pathway to improving patient outcomes with atherosclerosis imaging: Who's motivated? SO AMERICAN HEART JOURNAL LA English DT Editorial Material ID CORONARY-ARTERY-DISEASE; COMPUTED-TOMOGRAPHY; BEHAVIORAL-CHANGE; HEART-DISEASE; LIFE-STYLE; PREVENTION; ADHERENCE; SMOKERS; CESSATION; CALCIUM C1 Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave,NW Bldg 2,Room 4A34, Washington, DC 20307 USA. EM allen.taylor@na.amedd.ormy.mil NR 24 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD DEC PY 2007 VL 154 IS 6 BP 1008 EP 1010 AR 1008-10 DI 10.1016/j.ahj.2007.08.017 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 237SH UT WOS:000251396200002 PM 18035068 ER PT J AU Gold, JF Boudreaux, DJ Rupard, EJ AF Gold, Jessica F. Boudreaux, Daniel J. Rupard, Erik J. TI Basal cell carcinoma with hepatic metastases SO AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS LA English DT Article DE basal cell carcinoma; metastases; hepatic metastases C1 [Gold, Jessica F.; Boudreaux, Daniel J.; Rupard, Erik J.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Gold, JF (reprint author), Madigan Army Med Ctr, Dept Internal Med, Tacoma, WA 98431 USA. EM jessica.gold@us.army.mil NR 4 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-3732 J9 AM J CLIN ONCOL-CANC JI Am. J. Clin. Oncol.-Cancer Clin. Trials PD DEC PY 2007 VL 30 IS 6 BP 661 EP 663 DI 10.1097/01.coc.0000229947.23994.a8 PG 3 WC Oncology SC Oncology GA 242FP UT WOS:000251710200018 PM 18091065 ER PT J AU Knapik, JJ Jones, SB Darakjy, S Hauret, KG Nevin, R Grier, T Jones, BH AF Knapik, Joseph J. Jones, Sarah B. Darakjy, Salima Hauret, Keith G. Nevin, Remington Grier, Tyson Jones, Bruce H. TI Injuries and injury risk factors among members of the United States Army Band SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE LA English DT Article DE physical activity; physical fitness; musician; vocalist; prior injury ID PHYSICAL-ACTIVITY; MUSCULOSKELETAL PROBLEMS; MEDICAL PROBLEMS; MUSIC STUDENTS; YOUNG MEN; EXTREMITY INJURIES; PIANO STUDENTS; OVERUSE INJURY; PREVALENCE; EPIDEMIOLOGY AB Background This project documented injuries in the professional musical performers of the US Army Band and used a multivariate approach to determine injury risk factors. Methods Injuries were obtained from a medical surveillance database. Administrative records from the Band provided fitness test scores, physical characteristics, performing unit (Blues, Ceremonial, Chorale, Chorus, Concert, Strings), and functional group (strings, winds, keyboard, vocal, percussion, brass). A questionnaire completed by 95% of the Band (n = 205) included queries on practice time, physical activity, tobacco use, and medical care. Results One or more injuries were diagnosed in 44 and 53% of Band members in the years 2004 and 2005, respectively. In univariate analysis, higher injury risk was associated with higher body mass index (BMI), less physical activity, prior injury, unit, functional group, and practice duration. In multivariate analysis, less self-rated physical activity, a prior injury, and functional group were independent risk factors. Conclusion In the US Army Band, about half the performers had a medical visit for an injury in a 1-year period and injury risk was associated with identifiable factors. Am. J. Ind. Med. 50:951-961, 2007. (c) 2007 Wiley-Liss, Inc. C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, 1570 Stark Rd, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@apg.amedd.army.mil OI Nevin, Remington/0000-0002-0534-1889 NR 65 TC 13 Z9 13 U1 2 U2 8 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0271-3586 J9 AM J IND MED JI Am. J. Ind. Med. PD DEC PY 2007 VL 50 IS 12 BP 951 EP 961 DI 10.1002/ajim.20532 PG 11 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 234GW UT WOS:000251149700010 PM 17979136 ER PT J AU Zheng, J Wang, R Zambraski, E Wu, D Jacobson, KA Liang, BT AF Zheng, Jingang Wang, Rubio Zambraski, Edward Wu, Dan Jacobson, Kenneth A. Liang, Bruce T. TI Protective roles of adenosine A1, A(2A), and A(3) receptors in skeletal muscle ischemia and reperfusion injury SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY LA English DT Article DE wild-type mice; creatine kinase; phosolipase C ID MUSCULAR-DYSTROPHY; TARGETED DELETION; MOUSE HEART; MAST-CELLS; KNOCK-OUT; IN-VIVO; MYOCARDIUM; ACTIVATION; KINASE; MICE AB Although adenosine exerts cardio-and vasculoprotective effects, the roles and signaling mechanisms of different adenosine receptors in mediating skeletal muscle protection are not well understood. We used a mouse hindlimb ischemia-reperfusion model to delineate the function of three adenosine receptor subtypes. Adenosine A(3) receptor-selective agonist 2-chloro-N-6-(3-iodobenzyl) adenosine-5'-N-methyluronamide (Cl-IBMECA; 0.07 mg/kg ip) reduced skeletal muscle injury with a significant decrease in both Evans blue dye staining (5.4 +/- 2.6%, n = 8 mice vs. vehicle-treated 28 +/- 6%, n = 7 mice, P < 0.05) and serum creatine kinase level (1,840 +/- 910 U/l, n = 13 vs. vehicle-treated 12,600 +/- 3,300 U/l, n = 14, P < 0.05), an effect that was selectively blocked by an A(3) receptor antagonist 3-ethyl-5-benzyl-2-methyl-6phenyl- 4-phenylethynyl-1,4-(+/-)-dihydropyridine-3,5-dicarboxylate (MRS-1191; 0.05 mg/kg). The adenosine A(1) receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA; 0.05 mg/kg) also exerted a cytoprotective effect, which was selectively blocked by the A1 antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 0.2 mg/kg). The adenosine A(2A) receptor agonist 2-p-(2-carboxyethyl) phenethylamino5' -N-ethylcarboxamidoadenosine (CGS-21680; 0.07 mg/kg)-induced decrease in skeletal muscle injury was selectively blocked by the A2A antagonist 2-(2-furanyl)-7-[ 3-(4-methoxyphenyl) propyl]-7Hpyrazolo[ 4,3-e] [1,2,4] triazolo[ 1,5-C] pyrimidin-5-amine (SCH-442416; 0.017 mg/kg). The protection induced by the A(3) receptor was abrogated in phospholipase C-beta 2/beta 3 null mice, but the protection mediated by the A(1) or A(2A) receptor remained unaffected in these animals. The adenosine A(3) receptor is a novel cytoprotective receptor that signals selectively via phospholipase C-beta and represents a new target for ameliorating skeletal muscle injury. C1 Univ Connecticut, Ctr Hlth, Pat & Jim Calhoun Cardiol Ctr, Farmington, CT 06030 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT USA. Natl Inst Hlth, Natl Inst Diabet & Digest & Kidney Dis, Mol Recognit Sect, Bethesda, MD USA. RP Liang, BT (reprint author), Univ Connecticut, Ctr Hlth, Pat & Jim Calhoun Cardiol Ctr, MC-3946,263 Farmington Ave, Farmington, CT 06030 USA. EM bliang@uchc.edu RI Jacobson, Kenneth/A-1530-2009 OI Jacobson, Kenneth/0000-0001-8104-1493 FU Intramural NIH HHS; NHLBI NIH HHS [R01 HL080706-13, R01 HL080706-10, R01 HL080706-11, R01 HL080706, R01 HL080706-12]; NIGMS NIH HHS [R01 GM054597] NR 43 TC 29 Z9 30 U1 0 U2 7 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6135 J9 AM J PHYSIOL-HEART C JI Am. J. Physiol.-Heart Circul. Physiol. PD DEC PY 2007 VL 293 IS 6 BP H3685 EP H3691 DI 10.1152/ajpheart.00819.2007 PG 7 WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Physiology GA 237TW UT WOS:000251400300054 PM 17921328 ER PT J AU Deshpande, KK Summers, RM Van Uitert, RL Franaszek, M Brown, L Dwyer, AJ Fletcher, JG Choi, JR Pickhardt, PJ AF Deshpande, Keshav K. Summers, Ronald M. Van Uitert, Robert L. Franaszek, Marek Brown, Linda Dwyer, Andrew J. Fletcher, Joel G. Choi, J. Richard Pickhardt, Perry J. TI Quality assessment for CT colonography: Validation of automated measurement of colonic distention and residual fluid SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article; Proceedings Paper CT International Symposium on Virtual Colonoscopy CY 2006 CL Boston, MA DE colon; colonography; CT; quality; virtual colonoscopy ID COMPUTED TOMOGRAPHIC COLONOGRAPHY; COLORECTAL NEOPLASIA; VIRTUAL COLONOSCOPY; CARBON-DIOXIDE; INSUFFLATION AB OBJECTIVE. The purpose of this study was to validate automated quality assessment (QA) software for CT colonography (CTC) by comparing results obtained with the software with results of interpretation by radiologists in the assessment of colonic distention and surface area obscured by residual fluid. MATERIALS AND METHODS. CTC scans of 30 patients were selected retrospectively to span ranges of luminal distention (well distended to poorly distended) and surface area covered by residual fluid (high amount of coverage to low amount of coverage). We used QA software developed in our laboratory to automatically measure the mean distention of each of five colonic segments (ascending, transverse, descending, sigmoid, and rectum). Three experienced radiologists visually graded each scan for distention and fluid coverage. Distention and fluid scores for specific segments were assessed with Bland-Altman analysis (mean difference with 95% limits of agreement) and the weighted kappa test. Interobserver and intraobserver variability was determined with the weighted kappa test. RESULTS. For distention scoring, the mean difference between radiologists and the QA software was 0.1% (95% limits of agreement, -25.6% and 25.9%). For fluid scoring, the mean difference was -0.6% (95% limits of agreement, -8.2% and 7.1%). There was moderate to good agreement (weighted kappa value, 0.50 - 0.78) between the radiologists' mean scores and the scores obtained with the QA software and for interreader and intrareader assessments of distention and fluid coverage. CONCLUSION. Results with the QA software agreed with radiologists' assessment of colonic distention and residual fluid coverage but were a more objective assessment. Use of this QA software can help standardize two important factors, distention and residual fluid coverage, that affect the quality of CTC, reducing two known causes of poor CTC performance. C1 NIH, Ctr Clin, Dept Diagnost Radiol, Bethesda, MD 20892 USA. Mayo Clin, Dept Radiol, Rochester, MN USA. Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Dept Radiol, Washington, DC USA. Univ Wisconsin, Sch Med, Dept Radiol, Madison, WI USA. RP Summers, RM (reprint author), NIH, Ctr Clin, Dept Diagnost Radiol, Bldg 10, Rm 1C368X, Bethesda, MD 20892 USA. EM rms@nih.gov FU Intramural NIH HHS NR 18 TC 9 Z9 9 U1 0 U2 3 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD DEC PY 2007 VL 189 IS 6 BP 1457 EP 1463 DI 10.2214/AJR.07.2327 PG 7 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 234NY UT WOS:000251172000031 PM 18029885 ER PT J AU Drummond, S Banks, KP Brown, S AF Drummond, Scott Banks, Kevin P. Brown, Stephen TI AJR teaching file: Lumbar radiculopathy and intraspinal mass SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID SPINAL HEMANGIOBLASTOMA C1 Brooke Army Med Ctr, Dept Radiol, Houston, TX 78234 USA. Lake Erie Coll Osteopath Med, Erie, PA USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Houston, TX 78234 USA. EM kevin.banks@amedd.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD DEC PY 2007 VL 189 IS 6 SU S BP S58 EP S60 DI 10.2214/AJR.07.7028 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 234OA UT WOS:000251172200004 PM 18029903 ER PT J AU Shogan, P Banks, KP Brown, S AF Shogan, Paul Banks, Kevin P. Brown, Stephen TI AJR teaching file: Intraventricular mass SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE intraventricular meningioma; meningioma ID RADIOLOGIC-PATHOLOGICAL CORRELATION C1 Brooke Army Med Ctr, Dept Radiol, Houston, TX 78234 USA. Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Shogan, P (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Houston, TX 78234 USA. EM kevin.banks@amedd.army.mil NR 5 TC 4 Z9 6 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD DEC PY 2007 VL 189 IS 6 SU S BP S55 EP S57 DI 10.2214/AJR.07.7027 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 234OA UT WOS:000251172200003 PM 18029902 ER PT J AU Pidcoke, HF Salinas, J Wanek, SM Concannon, M Loo, F Wirfel, KL Holcomb, JB Wolf, SE Wade, CE AF Pidcoke, Heather F. Salinas, Jose Wanek, Sandra M. Concannon, Marybeth Loo, Florence Wirfel, Kelly L. Holcomb, John B. Wolf, Steven E. Wade, Charles E. TI Patterns of exogenous insulin requirement reflect insulin sensitivity changes in trauma SO AMERICAN JOURNAL OF SURGERY LA English DT Article; Proceedings Paper CT 59th Annual Meeting of the Southwestern-Surgical-Congress CY MAR 25-29, 2007 CL Rancho Mirage, CA SP SW Surg Congress DE hyperglycemia; trauma; diurnal variation; circadian rhythm; insulin sensitivity; insulin resistance ID CRITICALLY-ILL PATIENTS; ADMISSION HYPERGLYCEMIA; PROTEIN CATABOLISM; CIRCULATING LEPTIN; GLYCEMIC CONTROL; GLUCOSE; MORTALITY; THERAPY; ASSOCIATION; VARIABILITY AB Introduction: We investigated patterns of blood glucose and exogenous insulin requirement in the intensive care unit, and questioned whether they reflect fluctuations in insulin activity. Methods: Records for burn intensive care unit patients with 7 days of glucose control with insulin were reviewed. Hourly blood glucose and insulin dose were matched for time collected and analyzed with linear and cosine regression. Frequency analysis identified recurring patterns. Results: Diurnal patterns of blood glucose and insulin requirement were noted (insulin troughs = noon; insulin peaks = midnight; glucose troughs = 5 AM; glucose peaks = 5 Pm). Average insulin requirement increased at a constant linear rate (slope =.013, r(2) =.57, P <= .001). Conclusions: Diurnal patterns in blood glucose and insulin requirement mirror those of healthy subjects and may reflect persistence of normal variability in insulin activity. The 5-bour offset in peaks and troughs is suggestive of complex interplay between insulin availability and receptor sensitivity. The insulin requirement to blood glucose ratio increased, evidence that insulin resistance progresses over time. (c) 2007 Excerpta Medica Inc. All rights reserved. C1 USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Pidcoke, HF (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM heather.pidcoke@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 FU NIGMS NIH HHS [1 R01 GM063120-04] NR 30 TC 5 Z9 5 U1 1 U2 1 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD DEC PY 2007 VL 194 IS 6 BP 798 EP 803 DI 10.1016/j.amjsurg.2007.08.022 PG 6 WC Surgery SC Surgery GA 236AS UT WOS:000251276000018 PM 18005774 ER PT J AU Abbott, K AF Abbott, Kevin TI Medication compliance in transplantation SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Editorial Material ID COST-EFFECTIVENESS; ADHERENCE C1 Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. RP Abbott, K (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, 6900 Georgia Ave, Washington, DC 20307 USA. EM kevin.abbott@amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 9 TC 2 Z9 2 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD DEC PY 2007 VL 7 IS 12 BP 2647 EP 2649 DI 10.1111/j.1600-6143.2007.01992.x PG 3 WC Surgery; Transplantation SC Surgery; Transplantation GA 226JK UT WOS:000250585100001 PM 17924998 ER PT J AU Cohen, SP Hurley, RW AF Cohen, Steven P. Hurley, Robert W. TI The ability of diagnostic spinal injections to predict surgical outcomes SO ANESTHESIA AND ANALGESIA LA English DT Review ID LOW-BACK-PAIN; MINIMUM FOLLOW-UP; LUMBAR TOTAL DISC; SACROILIAC JOINT PAIN; NERVE ROOT BLOCKS; PERIARTICULAR CORTICOSTEROID TREATMENT; PERCUTANEOUS RADIOFREQUENCY NEUROTOMY; CHARITE(TM) ARTIFICIAL DISC; CHRONIC NECK PAIN; COMPUTED-TOMOGRAPHY AB BACKGROUND: Since their first description more than 80 yr ago, the use of diagnostic spinal injections to predict surgical outcomes has been the subject of intense controversy. Because there are no standardized guidelines or substantive reviews on this topic, their use has remained inconsistent. METHODS: Diagnostic procedures included in this review were lumbar and cervical discography, lumbar facet blocks, lumbar and cervical selective nerve root blocks, and sacroiliac (SI) joint injections. We garnered materials via MEDLINE and OVID search engines, books and book chapters, bibliographic references, and conference proceedings. RESULTS: The lack of randomized, comparative studies for all blocks limited the conclusions that could be drawn. For the data that do exist, there is limited evidence that lumbar discography improves fusion outcomes, and no evidence that it influences disk replacement results. Although limited in scope, the current literature supports the notion that cervical discography improves surgical outcomes. There is strong evidence that lumbar selective nerve root blocks improve the identification of a symptomatic nerve root(s), and moderate evidence that both lumbar and cervical nerve root blocks improve surgical outcomes. The data supporting surgery for facet arthropathy are weak, and the use of screening blocks does not appear to improve outcomes. The data supporting SI joint fusion for degenerative, nontraumatic injuries are similarly weak. Because the most reliable method to diagnose a painful SI joint is with low volume, diagnostic injections, one might reasonably conclude that screening blocks improve surgical outcomes. However, this conclusion is not supported by indirect evidence. CONCLUSIONS: The ability to evaluate the effect of diagnostic blocks on surgical outcomes is limited by a lack of randomized studies, methodological flaws, and wide-ranging discrepancies with regard to injection variables, surgical technique, and outcome measures. More research is needed to optimize injection techniques and determine which, if any, diagnostic screening blocks can improve surgical outcomes. C1 Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Pain Management Div, Baltimore, MD USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Cohen, SP (reprint author), Johns Hopkins Univ, Pain Mangment Div, 550 N Broadway, Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 171 TC 43 Z9 45 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD DEC PY 2007 VL 105 IS 6 BP 1756 EP 1775 DI 10.1213/01.ane.0000287637.30163.a2 PG 20 WC Anesthesiology SC Anesthesiology GA 236AC UT WOS:000251274400042 PM 18042881 ER PT J AU Harris, KC Rathmell, JP AF Harris, Kenneth C. Rathmell, James P. TI Forward-deployed anesthesiologists and pain treatment in combat support hospitals - Making decisions about deployment of anesthesiologists in support of the Global War on Terrorism SO ANESTHESIOLOGY LA English DT Editorial Material ID RISK-FACTORS C1 USA, Med Corps, Ft Sam Houston, TX 78234 USA. Massachusetts Gen Hosp, Massachusetts Gen Hosp Pain Ctr, Dept Anesthesia & Crit Care, Harvard Med Sch, Boston, MA USA. RP Harris, KC (reprint author), USA, Med Corps, Ft Sam Houston, TX 78234 USA. EM jrathmell@partners.org NR 3 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD DEC PY 2007 VL 107 IS 6 BP 872 EP 874 PG 3 WC Anesthesiology SC Anesthesiology GA 236AM UT WOS:000251275400004 PM 18043054 ER PT J AU Stojadinovic, A Mittendorf, EA Holmes, JP Amin, A Hueman, MT Ponniah, S Peoples, GE AF Stojadinovic, Alexander Mittendorf, Elizabeth A. Holmes, Jarrod P. Amin, Asna Hueman, Matthew T. Ponniah, Sathibalan Peoples, George E. TI Quantification and phenotypic characterization of circulating tumor cells for monitoring response to a preventive HER2/neu vaccine-based immunotherapy for breast cancer: A pilot study SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE breast cancer; peptide; vaccine; circulating tumor cells ID CYTOTOXIC T-LYMPHOCYTES; METASTATIC BREAST; OVARIAN-CANCER; IMMUNE-RESPONSE; E75 VACCINE; PEPTIDE; HER-2/NEU; IMMUNIZATION; PROGRESSION; RECURRENCE AB Background: Ongoing cancer vaccine trials are limited by the inability of immunologic assays to monitor clinically relevant surrogates of response. Recent advances in the ability to quantify and phenotype circulating tumor cells (CTCs) in breast cancer patients may lead to a role for CTCs in monitoring response to vaccine-based immunotherapy. Methods: The CellSearch System (Veridex-LLC, Warren, NJ) was used to enumerate total and HER2/neu(+) CTCs in 20 mL of blood from all 16 node-positive (NP) breast cancer patients active in our NP HER2/neu E75 peptide vaccine trial at the initiation of this pilot study. These patients were vaccinated with E75 (1000 mu g)/GM-CSF (250 mu g) monthly x 6 after completion of multimodality therapy. Mean (+/- SEM) number of CTCs and HER2/neu(+) CTCs were compared in unmatched (n = 16) and matched (n = 9) prevaccination and postvaccination cases. Results: CTCs were detected in 14 of 16 (88%) patients (mean: 3.4 +/- 0.2 CTC/20 mL). After vaccination, a reduction in CTC/20 mL (prevaccination 3.9 +/- 1.5 vs postvaccination 0.7 +/- 0.4, P = .077) and HER2/neu(+) CTC/20 mL (prevaccination 2.8 +/- 1.0 vs postvaccination 0.5 +/- 0.2, P = .048) was demonstrated. A significant delayed-type hypersensitivity (DTH) response suggesting that vaccination was effective in eliciting a peptide-specific immune response was confirmed (22.3 +/- 4.1 vs 3.0 +/- 2.2 [controls] mm, P < .01). All nine patients followed throughout the vaccination series also showed significant reduction in CTCs (4.8 +/- 1.5 vs 0.3 +/- 0.2, P < .01) and HER2/neu(+) CTCs (3.0 +/- 0.9 vs 0.4 +/- 0.2, P = .013). Conclusions: CTCs are readily demonstrated in posttreatment, clinically disease-free NP breast cancer patients. E75+GM-CSF vaccination appears to reduce the number of CTCs. These data suggest a potential role for this clinically validated CTC assay in assessing response to preventive vaccine-based immunotherapy, and further validation studies are underway. C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA. UTMD Anderson Canc Ctr, Dept Surg, Houston, TX USA. Natl Naval Med Ctr, Dept Med, Bethesda, MD USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC USA. Brooke Army Med Ctr, Dept Surg, Houston, TX USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. EM alexander.stojadinovic@amedd.army.mil NR 21 TC 12 Z9 14 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD DEC PY 2007 VL 14 IS 12 BP 3359 EP 3368 DI 10.1245/s10434-007-9538-x PG 10 WC Oncology; Surgery SC Oncology; Surgery GA 231VE UT WOS:000250976500016 PM 17906897 ER PT J AU Ambrose, PG Forrest, A Craig, WA Rubino, CM Bhavnani, SM Drusano, GL Heine, HS AF Ambrose, Paul G. Forrest, Alan Craig, William A. Rubino, Chistopher M. Bhavnani, Sujata M. Drusano, George L. Heine, Henry S. TI Pharmacokinetics-pharmacodynamics of gatifloxacin in a lethal murine Bacillus anthracis inhalation infection model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID POSTEXPOSURE PROPHYLAXIS; IDENTIFICATION; SELECTION; THERAPY; MICE AB We determined the pharmacokinetic-pharmacodynamic (PK-PD) measure most predictive of gatifloxacin efficacy and the magnitude of this measure necessary for survival in a murine Bacillus anthracis inhalation infection model. We then used population pharmacokinetic models for gatifloxacin and simulation to identify dosing regimens with high probabilities of attaining exposures likely to be efficacious in adults and children. In this work, 6- to 8-week-old nonneutropenic female BALB/c mice received aerosol challenges of 50 to 75 50% lethal doses of B. anthracis (Ames strain, for which the gatifloxacin MIC is 0.125 mg/liter). Gatifluxacin was administered at 6- or 8-h intervals beginning 24 111 postchallenge for 21 days, and dosing was designed to produce profiles mimicking fractionated concentration-time profiles for humans. Mice were evaluated daily for survival. Hill-type models were fitted to survival data. To identify potentially effective dosing regimens, adult and pediatric population pharmacokinetic models for gatiffoxacin and Monte Carlo simulation were used to generate 5,000 individual patient exposure estimates. The ratio of the area under the concentration-time curve from 0 to 24 h (AUC(0-24)) to the MIC of the drug for the organism (AUC(0-24)/MIC ratio) was the PK-PD measure most predictive of survival (R-2 = 0.96). The 50% effective dose (ED50) and the ED90 and ED99 corresponded to AUC(0-24)/MIC ratios of 11.5, 15.8, and 30, respectively, where the maximum effect was 97% survival. Simulation results indicate that a daily gatifloxacin dose of 400 mg for adults and 10 mg/kg of body weight for children gives a 100% probability of attaining the PK-PD target (ED99). Sensitivity analyses suggest that the probability of PK-PD target attainment in adults and children is not affected by increases in MICs for strains of B. anthracis to levels as high as 0.5 mg/liter. C1 Ordway Res Inst, Inst Clin Pharmacodynam, Albany, NY USA. Univ Buffalo, Sch Pharm & Pharmaceut Sci, Buffalo, NY USA. William S Middleton Mem VA Med Ctr, Madison, WI USA. Ordway Res Inst, Emerging Infect & Fungal Pharmacodynam Lab, Albany, NY USA. US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Ambrose, PG (reprint author), ICPD, Ordway Res Inst, 150 New Scotland Ave, Albany, NY 12208 USA. EM PAmbrose-ICPD@OrdwayResearch.org FU NIAID NIH HHS [1P01-AI060908-01A1, P01 AI060908] NR 25 TC 7 Z9 7 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2007 VL 51 IS 12 BP 4351 EP 4355 DI 10.1128/AAC.00251-07 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 238UB UT WOS:000251472100021 PM 17875992 ER PT J AU Hawley, JS Murray, CK Jorgensen, JH AF Hawley, Joshua S. Murray, Clinton K. Jorgensen, James H. TI Development of colistin-dependent Acinetobacter baumannii-Acinetobacter calcoaceticus complex SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Letter ID VANCOMYCIN; INFECTION C1 Tripler Army Med Ctr, Dept Med, Infect Dis Serv, Honolulu, HI 96859 USA. RP Hawley, JS (reprint author), Tripler Army Med Ctr, Dept Med, Infect Dis Serv, MCHE MDI 7E,3851 Roger Brooke Dr, Honolulu, HI 96859 USA. EM Clinton.Murray@amedd.army.mil NR 9 TC 13 Z9 16 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2007 VL 51 IS 12 BP 4529 EP 4530 DI 10.1128/AAC.01115-07 PG 2 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 238UB UT WOS:000251472100056 PM 17876007 ER PT J AU Chang, MH Youree, RK AF Chang, Mou-Hsiung Youree, Roger K. TI Infinite-dimensional black-scholes equation with hereditary structure SO APPLIED MATHEMATICS AND OPTIMIZATION LA English DT Article DE option pricing; european option; generalized Black-Scholes formula; stochastic functional differential equations ID OPTION AB This paper considers the option pricing problem for contingent claims of the European type in a (B, S)-market in which the stock price and the asset in the riskless bank account both have hereditary structures. The Black-Scholes equation for the classical option pricing problem is generalized to an infinite-dimensional equation to include the effects of time delay in the evolution of the financial market as well as a very general payoff function. A computational algorithm for the solution is also obtained via a double sequence of polynomials of a certain bounded linear functional on a Banach space and the time variable. C1 US Army Res Off, Res Triangle Pk, NC 27709 USA. Instrumental Sci Inc, Huntsville, AL 35811 USA. RP Chang, MH (reprint author), US Army Res Off, PO Box 12211, Res Triangle Pk, NC 27709 USA. EM mouhsiung.chang@us.army.mil NR 25 TC 6 Z9 6 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0095-4616 J9 APPL MATH OPT JI Appl. Math. Optim. PD DEC PY 2007 VL 56 IS 3 BP 395 EP 424 DI 10.1007/s00245-007-9003-z PG 30 WC Mathematics, Applied SC Mathematics GA 235LH UT WOS:000251235100006 ER PT J AU Hanna, S White, J Zhou, Y AF Hanna, Steven White, John Zhou, Ying TI Observed winds, turbulence, and dispersion in built-up downtown areas of Oklahoma City and Manhattan SO BOUNDARY-LAYER METEOROLOGY LA English DT Article DE similarity laws; turbulence in cities; urban boundary layers; urban dispersion ID URBAN AREAS; FLOW; LAYER; MARSEILLES; ROUGHNESS; PROFILES; HEAT AB Madison Square Garden 2005 (MSG05) urban field experiments are being analyzed to aid in understanding air flow and dispersion near street-level in built-up downtown areas. The mean winds are separately calculated for groups of anemometers having similar exposures such as "near street level" and "on building top". Several general results are found, such as the scalar wind speed at street level is about 1/3 of that at building top. Turbulent standard deviations of wind speed components and temperature, and vertical fluxes of momentum and sensible heat, are calculated from sonic anemometers near street level at 20 locations in JU2003 and five locations in MSG05, and from two rooftop locations in MSG05. The turbulence observations are consistent with observations in the literature at other cities, although the JU2003 and MSG05 data are unique in that many data are available near street level. For example, it is found that the local (i.e., at the measuring height) sigma(w)/u(*) averages about 1.5 and the local u(*)/u averages about 0.25 in the two cities, where sigma(w) is the standard deviation of vertical velocity fluctuations, u(*) is the friction velocity, and u(*) is the wind speed. The ratio of temperature fluctuations to temperature scale, sigma(T)/T-*, averages about -3 in both cities, consistent with similarity theory for slightly unstable conditions, where sigma(T) is the standard deviation of temperature fluctuations, and T-* is the temperature scale. The calculated Obukhov length, L, is also consistent with slightly unstable conditions near street level, even at night during JU2003. The SF6 tracer concentration observations from JU2003 are analyzed. Values of uC(max)/Q for the continuous releases are calculated for each release and arc distance, where C-max is the 30-min average arc maximum concentration, Q is the continuous source emission rate, and u(*) is the spatial-averaged wind speed in the downtown area. The basic characteristics of the JU2003 plot of averaged uC(max)/ Q agree reasonably well with similar plots for other urban experiments in Salt Lake City and London (i.e., at x < 1000 m, C-max/Q = Ax(-2)). A is found to be about 3 during the day and about 10 during the night. C1 Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA. USA, Salt Lake City, UT USA. RP Hanna, S (reprint author), 7 Crescent Ave, Kennebunkport, ME 04046 USA. NR 37 TC 40 Z9 44 U1 2 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD DEC PY 2007 VL 125 IS 3 BP 441 EP 468 DI 10.1007/s10546-007-9197-2 PG 28 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 226HH UT WOS:000250579500003 ER PT J AU Bekash, A Maskery, SM Kvecher, L Hooke, J Liebman, MN Shriver, CD Mural, RJ Hu, H AF Bekash, A. Maskery, S. M. Kvecher, L. Hooke, J. Liebman, M. N. Shriver, C. D. Mural, R. J. Hu, H. TI A pilot study of known or controversial breast cancer risk factors using the Clinical Breast Care Project database as a research environment. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Winber Res Inst, Windner, PA USA. Walter Reed Army Med Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S176 EP S176 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500488 ER PT J AU Callaghan, KA Weyandt, JD Ellsworth, RE Shriver, CD AF Callaghan, K. A. Weyandt, J. D. Ellsworth, R. E. Shriver, C. D. TI Identification of genetic predisposition to development of lymph node metastasis in breast cancer patients SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S27 EP S28 PG 2 WC Oncology SC Oncology GA 237TE UT WOS:000251398500073 ER PT J AU Carmichael, M Holmes, JP Mittendorf, EA Amin, A Hueman, MT Ponniah, S Peoples, GE AF Carmichael, M. Holmes, J. P. Mittendorf, E. A. Amin, A. Hueman, M. T. Ponniah, S. Peoples, G. E. TI Clinical results of a phase I trial of a HER2/neu-derived peptide (GP2) vaccine in disease-free, node-negative breast cancer patients SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 USUHS, Bethesda, MD USA. Natl Naval Med Ctr, Bethesda, MD USA. Univ Texas MD Anderson Canc Ctr, Houston, TX USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S30 EP S31 PG 2 WC Oncology SC Oncology GA 237TE UT WOS:000251398500082 ER PT J AU Ellsworth, DL Seeley, EH Ellsworth, RE Deyarmin, B Sanders, ME Hooke, JA Caprioli, RM Shriver, CD AF Ellsworth, D. L. Seeley, E. H. Ellsworth, R. E. Deyarmin, B. Sanders, M. E. Hooke, J. A. Caprioli, R. M. Shriver, C. D. TI Tumor microenvironment in breast cancer metastasis: direct tissue protein profiling of tumor-associated stroma from invasive breast cancer patients with versus without axillary lymph node metastasis SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Vanderbilt Univ, Nashville, TN USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S244 EP S244 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500685 ER PT J AU Ellsworth, DL Ellsworth, RE Painey, HL Becker, TE Deyarmin, B Jordan, RM Hooke, JA Shriver, CD AF Ellsworth, D. L. Ellsworth, R. E. Painey, H. L. Becker, T. E. Deyarmin, B. Jordan, R. M. Hooke, J. A. Shriver, C. D. TI Primary tumor heterogeneity and sentinel lymph node metastases: understanding molecular processes of breast cancer metastasis SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S27 EP S27 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500072 ER PT J AU Ellsworth, RE Deyarmin, B Patney, HL Hooke, JA Shriver, CD AF Ellsworth, R. E. Deyarmin, B. Patney, H. L. Hooke, J. A. Shriver, C. D. TI HER-2 gene amplification is a marker for global genomic instability SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S284 EP S285 PG 2 WC Oncology SC Oncology GA 237TE UT WOS:000251398500801 ER PT J AU Ellsworth, RE Patney, HL Ellsworth, DL Love, B Hooke, JA Shriver, CD AF Ellsworth, R. E. Patney, H. L. Ellsworth, D. L. Love, B. Hooke, J. A. Shriver, C. D. TI Genomic discrimination of metastatic from non-metastatic primary breast tumors SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Invitrogen Informat, Carlsbad, CA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S244 EP S244 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500684 ER PT J AU Ellsworth, RE Hooke, JA Ellsworth, DL Shriver, CD AF Ellsworth, R. E. Hooke, J. A. Ellsworth, D. L. Shriver, C. D. TI Contribution of chromosomal alterations to the development of poorly-differentiated invasive breast carcinomas SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S157 EP S157 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500435 ER PT J AU Ellsworth, RE Seeley, EH Ellsworth, DL Sanders, M Hooke, JA Caprioli, RM Shriver, CD AF Ellsworth, R. E. Seeley, E. H. Ellsworth, D. L. Sanders, M. Hooke, J. A. Caprioli, R. M. Shriver, C. D. TI Identification of protein expression differences in invasive breast tumors from African American compared to Caucasian women SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Vanderbilt Univ, Nashville, TN USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S141 EP S141 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500393 ER PT J AU Field, LA Seebach, JF Love, BJ Deyarmin, B Kane, J Hooke, JA Ellsworth, RE Shriver, CD AF Field, L. A. Seebach, J. F. Love, B. J. Deyarmin, B. Kane, J. Hooke, J. A. Ellsworth, R. E. Shriver, C. D. TI Identification of gene expression differences in primary breast tumors from node-negative and node-positive women SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Invitrogen Informat, Carlsbad, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S243 EP S243 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500682 ER PT J AU Field, LA Love, BJ Hadix, JA Ellsworth, RE Shriver, CD AF Field, L. A. Love, B. J. Hadix, J. A. Ellsworth, R. E. Shriver, C. D. TI Identification of blood-based biomarkers for the detection of breast cancer and lymph node status SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Invitrogen Informat, Carlsbad, CA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S211 EP S211 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500588 ER PT J AU Holmes, JP Patil, R Amin, A Jama, YH McNeill, A Hueman, MT Craig, D Ponniah, S Peoples, GE AF Holmes, J. P. Patil, R. Amin, A. Jama, Y. H. McNeill, A. Hueman, M. T. Craig, D. Ponniah, S. Peoples, G. E. TI Optimal dose and schedule of a HER2/neu peptide (E75) vaccine in disease-free breast cancer patients: results from two phase I/II clinical trials SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Natl Naval Med Ctr, Bethesda, MD USA. Windber Med Ctr, Windber, PA USA. USUHS, Bethesda, MD USA. Brooke Army Med Ctr, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S30 EP S30 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500081 ER PT J AU Hu, H Stegmaier, P Field, LA Kel, A Shriver, CD Liebman, MN Mural, RJ AF Hu, H. Stegmaier, P. Field, L. A. Kel, A. Shriver, C. D. Liebman, M. N. Mural, R. J. TI A transcription factor-centric computational analysis of genes differentially expressed in healthy breast tissues from African American and Caucasian women SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. BIOBASE GmbH, Wolfenbuttel, Germany. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S141 EP S141 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500392 ER PT J AU Jordan, RM Hu, H Heckman, CM Kvecher, L Shriver, CD Mural, R Yang, YC AF Jordan, R. M. Hu, H. Heckman, C. M. Kvecher, L. Shriver, C. D. Mural, R. Yang, Y. C. TI Peripheral blood microarray data may aid in predicting lymph node status of breast cancer patients SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S129 EP S129 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500356 ER PT J AU Maskery, S Hu, H Liebman, M Shriver, C Verbanac, K Tafra, L Rosman, M AF Maskery, S. Hu, H. Liebman, M. Shriver, C. Verbanac, K. Tafra, L. Rosman, M. TI Bayesian analysis of recurrence in lymph node positive and lymph node negative breast cancer patients SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. E Carolina Univ, Greenville, NC USA. Ann Arundel Med Ctr, Annapolis, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S219 EP S219 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500611 ER PT J AU Maskery, SM Hu, H Liebman, M Hooke, J Shriver, CD Taioli, E AF Maskery, S. M. Hu, H. Liebman, M. Hooke, J. Shriver, C. D. Taioli, E. TI Traditional breast cancer risk factors and common breast pathologies in post-menopausal women. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windler Res Inst, Winber, PA USA. Walter Reed Army Med Ctr, Washington, DC USA. Univ Pittsburgh, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S175 EP S175 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500486 ER PT J AU Paul, R Holmes, JP Amin, A Carmichael, M Jama, YH McNeill, A Hueman, MT Craig, D Ponniah, S Peoples, GE AF Paul, R. Holmes, J. P. Amin, A. Carmichael, M. Jama, Y. H. McNeill, A. Hueman, M. T. Craig, D. Ponniah, S. Peoples, G. E. TI Clinical and immunologic responses of HLA-A3(+) breast cancer patients vaccinated with the HER2/neu-derived peptide vaccine, E75, in a phase I clinical trial. SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Windber Med Ctr, Windber, PA USA. Natl Naval Med Ctr, Bethesda, MD USA. USUHS, Bethesda, MD USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S123 EP S124 PG 2 WC Oncology SC Oncology GA 237TE UT WOS:000251398500341 ER PT J AU Seebach, J Field, LA Love, B Hollern, K Hooke, JA Ellsworth, RE Shriver, CD AF Seebach, J. Field, L. A. Love, B. Hollern, K. Hooke, J. A. Ellsworth, R. E. Shriver, C. D. TI Identification of a gene expression breast cancer metastasis profile SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Meeting Abstract CT 30th Annual San Antonio Breast Cancer Symposium CY DEC 13-16, 2007 CL San Antonio, TX SP San Antonio Canc Inst, Baylor Coll Med C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Windber Res Inst, Windber, PA USA. Invitrogen Informat, Carlsbad, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD DEC PY 2007 VL 106 SU 1 BP S244 EP S244 PG 1 WC Oncology SC Oncology GA 237TE UT WOS:000251398500683 ER PT J AU Frias-Staheli, N Giannakopoulos, NV Kikkert, M Taylor, SL Bridgen, A Paragas, J Richt, JA Rowland, RR Schmaljohn, CS Lenschow, DJ Snijder, EJ Garcia-Sastre, A Virgin, HW AF Frias-Staheli, Natalia Giannakopoulos, Nadia V. Kikkert, Marjolein Taylor, Shannon L. Bridgen, Anne Paragas, Jason Richt, Juergen A. Rowland, Raymond R. Schmaljohn, Connie S. Lenschow, Deborah J. Snijder, Eric J. Garcia-Sastre, Adolfo Virgin, Herbert Whiting TI Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses SO CELL HOST & MICROBE LA English DT Article ID NF-KAPPA-B; RESPIRATORY SYNDROME CORONAVIRUS; CONGO-HEMORRHAGIC-FEVER; PAPAIN-LIKE PROTEASE; INFLUENZA-A VIRUS; DEUBIQUITINATING ENZYME; NS1 PROTEIN; ANTIVIRAL MOLECULE; STIMULATED GENE-15; CYSTEINE PROTEASES AB Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to proteins and mediate important innate antiviral responses. The ovarian tumor (OTU) domain represents a superfamily of predicted proteases found in eukaryotic, bacterial, and viral proteins, some of which have Ub-deconjugating activity. We show that the OTU domain-containing proteases f rom nairoviruses and arteriviruses, two unrelated groups of RNA viruses, hydrolyze Ub and ISG15 from cellular target proteins. This broad activity contrasts with the target specificity of known mammalian OTU domain-containing proteins. Expression of a viral OTU domain-containing protein antagonizes the antiviral effects of ISG15 and enhances susceptibility to Sindbis virus infection in vivo. We also show that viral OTU domain-containing proteases inhibit NF-kappa B-dependent signaling. Thus, the deconjugating activity of viral OTU proteases represents a unique viral strategy to inhibit Ub- and ISG15dependent antiviral pathways. C1 [Frias-Staheli, Natalia; Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA. [Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Dept Med, Div Infect Dis, New York, NY 10029 USA. [Garcia-Sastre, Adolfo] Mt Sinai Sch Med, Emerging Pathogens Inst, New York, NY 10029 USA. [Giannakopoulos, Nadia V.; Lenschow, Deborah J.; Virgin, Herbert Whiting] Washington Univ, Sch Med, Dept Pathol & Immunol, Dept Mol Microbiol, St Louis, MO 63110 USA. [Lenschow, Deborah J.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA. [Kikkert, Marjolein; Snijder, Eric J.] Leiden Univ, Med Ctr, Ctr Infect Dis,LUMC, Dept Med Microbiol,Mol Virol Lab, NL-2300 RC Leiden, Netherlands. [Taylor, Shannon L.; Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Bridgen, Anne] Univ Ulster, Dept Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland. [Paragas, Jason] NIH, NIAID, Emerging Viral Pathogens Sect, Bethesda, MD 20892 USA. [Richt, Juergen A.] USDA ARS, Natl Anim Dis Ctr, Ames, IA 50010 USA. [Rowland, Raymond R.] Kansas State Univ, Manhattan, KS 66506 USA. RP Garcia-Sastre, A (reprint author), Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA. EM adolfo.garcia-sastre@mssm.edu; virgin@wustl.edu OI Garcia-Sastre, Adolfo/0000-0002-6551-1827 FU NIAID NIH HHS [U54 AI057160, U19 AI62623, U54 AI057158-010003, U54 AI057158, U19 AI062623-010003, U19 AI062623] NR 53 TC 181 Z9 192 U1 2 U2 7 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1931-3128 J9 CELL HOST MICROBE JI Cell Host Microbe PD DEC PY 2007 VL 2 IS 6 BP 404 EP 416 DI 10.1016/j.chom.2007.09.014 PG 13 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 244GY UT WOS:000251855600006 PM 18078692 ER PT J AU Bednar, AJ Medina, VF Ulmer-Scholle, DS Frey, BA Johnson, BL Brostoff, WN Larson, SL AF Bednar, A. J. Medina, V. F. Ulmer-Scholle, D. S. Frey, B. A. Johnson, B. L. Brostoff, W. N. Larson, S. L. TI Effects of organic matter on the distribution of uranium in soil and plant matrices SO CHEMOSPHERE LA English DT Article DE uranium; complexation; organic matter; speciation ID DEPLETED URANIUM; ARSENIC SPECIATION; HUMIC-ACID; COMPLEXATION; TRANSPORT; SORPTION; WATER; SOLUBILITY; ADSORPTION; CARBONATE AB This work studied interactions of uranium with pure organic compounds, such as glutathione, and more complex mixtures, such as humic acid and aqueous plant extracts. High performance liquid chromatography with UV absorption interfaced to inductively coupled plasma mass spectrometry sequential detection was used to detect organouranium complexes in a variety of soils and plant materials, indicating that nearly 100% of the uranium extracted from certain plant tissues was bound to organic ligands. In addition, soil sorption experiments indicated that humic acid generally decreased uranium sorption to soils and promoted subsequent desorption of uranium because of uranium partitioning to the organic phase. These experiments demonstrate that organic compounds influence the mobility and chemistry of uranium in the environment. Published by Elsevier Ltd. C1 [Bednar, A. J.; Medina, V. F.; Johnson, B. L.; Larson, S. L.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ulmer-Scholle, D. S.] New Mexico Inst Min & Technol, Dept Earth & Environm Sci, Socorro, NM 87801 USA. [Frey, B. A.] New Mexico Inst Min & Technol, New Mexico Bureau Geol & Mineral Resources, Socorro, NM 87801 USA. [Brostoff, W. N.] USA, Corps Engineers, San Francisco, CA 94103 USA. RP Bednar, AJ (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@erdc.usace.army.mil NR 39 TC 35 Z9 37 U1 3 U2 31 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD DEC PY 2007 VL 70 IS 2 BP 237 EP 247 DI 10.1016/j.chemosphere.2007.06.032 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA 242DS UT WOS:000251705300009 PM 17709130 ER PT J AU Avalos, E Doney, RL Sen, S AF Avalos, Edgar Doney, Robert L. Sen, Surajit TI Interaction of solitary waves in confined granular alignments and the quasi-equilibrium state SO CHINESE JOURNAL OF PHYSICS LA English DT Article; Proceedings Paper CT 5th Workshop on Nonlinear Phenomena in Physical and Biological Systems CY NOV 03-05, 2006 CL NCHU, HuiSun Forest Stn, NanTou, TAIWAN HO NCHU, HuiSun Forest Stn ID QUARTZ BEADS; PROPAGATION; PULSES; CHAIN; BACKSCATTERING; COLUMNS; PHASE AB We consider a chain of elastic beads, in which the individual grains repel upon contact according to the non-linear Hertz potential. We further assume that the chain is under zero loading, i.e., the grains barely touch one another. We show via careful numerical solution of the equations of motion that an impulse propagates as a solitary wave and that the collision of identical solitary waves propagating in opposite directions along the chain spawns a hierarchy of multiple weak solitary waves. We mention that the generated baby waves eventually must lead to a "volatile" equilibrium-like state, which we refer to as the quasi-equilibrium state. C1 [Avalos, Edgar] Natl Cent Univ, Grad Inst Biophys, Chungli 320, Taiwan. [Avalos, Edgar] Natl Cent Univ, Ctr Complex Syst, Chungli 320, Taiwan. [Doney, Robert L.] USA, Ballist Res Labs, Aberdeen Proving Ground, MD 21005 USA. [Sen, Surajit] SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA. RP Avalos, E (reprint author), Natl Cent Univ, Grad Inst Biophys, Chungli 320, Taiwan. NR 25 TC 9 Z9 9 U1 0 U2 4 PU PHYSICAL SOC REPUBLIC CHINA PI TAIPEI PA CHINESE JOURNAL PHYSICS PO BOX 23-30, TAIPEI 10764, TAIWAN SN 0577-9073 J9 CHINESE J PHYS JI Chin. J. Phys. PD DEC PY 2007 VL 45 IS 6 BP 666 EP 674 PN 2 PG 9 WC Physics, Multidisciplinary SC Physics GA 246GY UT WOS:000251996700004 ER PT J AU Satterfield, BC Kulesh, DA Norwood, DA Wasteloski, LP Caplan, MR West, JAA AF Satterfield, Brent C. Kulesh, David A. Norwood, David A. Wasteloski, Leonard P., Jr. Caplan, Michael R. West, Jay A. A. TI Tentacle Probes (TM): Differentiation of difficult single-nucleotide polymorphisms and deletions by presence or absence of a signal in real-time PCR SO CLINICAL CHEMISTRY LA English DT Article ID POLYMERASE-CHAIN-REACTION; BACILLUS-ANTHRACIS; YERSINIA-PESTIS; MOLECULAR BEACONS; SEQUENCE CONSERVATION; HYBRIDIZATION PROBES; DNA AMPLIFICATION; ASSAYS; PSEUDOTUBERCULOSIS; SAMPLES AB Background: False-positive results are a common problem in real-time PCR identification of DNA sequences that differ from near neighbors by a single-nucleotide polymorphism (SNP) or deletion. Because of a lack of sufficient probe specificity, post-PCR analysis, such as a melting curve, is often required for mutation differentiation. Methods: Tentacle Probes(TM), cooperative reagents with both a capture and a detection probe based on specific cell-targeting principles, were developed as a replacement for 2 chromosomal TaqMan-minor groove binder (MGB) assays previously developed for Yersinia pestis and Bacillus anthracis detection. We compared TaqMan-MGB probes to Tentacle Probes for SNP and deletion detection based on the presence or absence of a growth curve. Results: With the TaqMan-MGB Y. pestis yp48 assays, false-positive results for Yersinia pseudotuberculosis occurred at every concentration tested, and with the TaqMan-MGB B. anthracis gyrA assays, false-positive results occurred in 21 of 29 boil preps of environmental samples of near neighbors. With Tentacle Probes no false-positive results occurred. Conclusions: The high specificity exhibited by Tentacle Probes may eliminate melting curve analysis for SNP and deletion mutation detection, allowing the diagnostic use of previously difficult targets. (C) 2007 American Association for Clinical Chemistry. C1 Arizona State Univ, Harrington Dept Bioengn, Tempe, AZ 85287 USA. Arcxis Biotechnol, Pleasanton, CA USA. USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Caplan, MR (reprint author), Arizona State Univ, Harrington Dept Bioengn, POB 879709, Tempe, AZ 85287 USA. EM Michael.Caplan@asu.edu FU NIDCR NIH HHS [K22 DE014846]; NINDS NIH HHS [R21 NS051310] NR 39 TC 6 Z9 7 U1 2 U2 3 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD DEC PY 2007 VL 53 IS 12 BP 2042 EP 2050 DI 10.1373/clinchem.2007.091488 PG 9 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 236CR UT WOS:000251281100003 PM 17932130 ER PT J AU Markotic, A Hensley, L Daddario, K Spik, K Anderson, K Schmaljohn, C AF Markotic, Alemka Hensley, Lisa Daddario, Kathleen Spik, Kristin Anderson, Kevin Schmaljohn, Connie TI Pathogenic hantaviruses elicit different immunoreactions in THP-1 cells and primary monocytes and induce differentiation of human monocytes to dendritic-like cells SO COLLEGIUM ANTROPOLOGICUM LA English DT Article DE pathogenic hantaviruses; THP-1 cells; primary monocytes; dendritic-like cells; cytokines/chemokines ID PERIPHERAL-BLOOD MONOCYTES; NECROSIS-FACTOR-ALPHA; HEMORRHAGIC-FEVER; RENAL SYNDROME; VIRUS-INFECTION; LINE THP-1; IN-VITRO; DISEASE; PUUMALA; INTERLEUKIN-1 AB Hantaviruses cause two important human illnesses, hemorrhagic fever with renal syndrome (HERS) and hantavirus pulmonary syndrome (HPS). Both syndromes are believed to be immune-mediated diseases. Monocytes/macrophages are thought to be the main target cells for hantaviruses and important sources of and targets for cytokines/chemokines secretion. THP-1 cells have been used extensively as models for primary monocytes in biocompatibility research. The aim of our study was to determine if hantaviruses induce the same immunoreactions in THP-1 cells and primary monocytesl macrophages and might therefore be suitable for immune studies of hantaviral infections. For that purpose we compared various cytokines/chemokines and their receptors in THP-1 cell line and primary monocytes/macrophages. Infected primary monocytes/macrophages induced mostly beta-chemokines and their receptors. In contrast, THP-1 cells, expressed receptors for CXC chemokines. Surprisingly, infected macrophages underwent morphological changes toward dendritic-like cells and increased expression of co-stimulatory molecules: CD40, CD80, CD83 and CD86. Our data indicate that THP-1 cells are not ideal for in vitro research of the immunopathogenesis of hantaviruses in humans. Further, our studies revealed potential roles for cytokines/chemokines in HFRS/HPS immunopathogenesis and point to intriguing possibilities for the possible differentiation of infected macrophages to dendritic-like cells. C1 [Markotic, Alemka] Univ Zagreb, Univ Hosp Infect Dis Dr Fran Mihaljevic, Sci Unit, Zagreb 10000, Croatia. [Hensley, Lisa; Daddario, Kathleen; Spik, Kristin; Anderson, Kevin; Schmaljohn, Connie] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Markotic, A (reprint author), Univ Zagreb, Univ Hosp Infect Dis Dr Fran Mihaljevic, Sci Unit, Mirogojska 8, Zagreb 10000, Croatia. EM alemka.markotic@bfm.hr NR 30 TC 17 Z9 17 U1 0 U2 1 PU COLLEGIUM ANTROPOLOGICUM PI ZAGREB PA INST ANTHROPOLOGICAL RES, P O BOX 290, ULICA GRADA VUKOVARA 72/IV, 10000 ZAGREB, CROATIA SN 0350-6134 J9 COLLEGIUM ANTROPOL JI Coll. Anthropol. PD DEC PY 2007 VL 31 IS 4 BP 1159 EP 1167 PG 9 WC Anthropology SC Anthropology GA 250NU UT WOS:000252308100040 PM 18217475 ER PT J AU Senchak, AJ Sato, AK Vazquez, R Keller, CE Cable, BB AF Senchak, Andrew J. Sato, Aileen K. Vazquez, Raymond Keller, Christopher E. Cable, Benjamin B. TI Characterization of transforming growth factors beta 1 and 2 in ferrets (Mustela putorius furo) SO COMPARATIVE MEDICINE LA English DT Article ID ACQUIRED SUBGLOTTIC STENOSIS; GROWTH-FACTOR-BETA; TGF-BETA; CELL-PROLIFERATION; FIBROBLASTS; TGF-BETA-2; EXPRESSION; ANTIBODY; MODEL AB Unwanted scar tissue after surgical procedures remains a central problem in medicine. Nowhere is this problem more evident than within the pediatric airway, where excess scarring, termed subglottic stenosis, can compromise breathing. Recent advances in molecular biology have focused on ways to decrease scar formation through understanding of the wound repair process. Transforming growth factor beta (TFG beta) plays a central role in this pathways Ferrets serve as an ideal model for the pediatric airway, and reproduction of subglottic stenosis in ferrets is possible. However, ferret cytokine profiles have not been established. In this study, we characterized the presence and nucleotide sequence of the TGF beta 1and 2 genes in ferrets by using total RNA isolated from airways. Amino acid sequence homology between human and ferret was determined to be 96.6% for TGF beta 1 and 99.3% for TG beta 2. Given the nearly total homology between TGF beta s of ferret and human origin, the ferret may serve as an ideal model for future molecular studies. C1 [Senchak, Andrew J.; Cable, Benjamin B.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. [Sato, Aileen K.; Vazquez, Raymond; Keller, Christopher E.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Senchak, AJ (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. EM andrew.senchak@amedd.army.mil RI Keller, Christopher/B-7886-2011 NR 22 TC 2 Z9 2 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD DEC PY 2007 VL 57 IS 6 BP 594 EP 596 PG 3 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 245RU UT WOS:000251954300011 PM 18246873 ER PT J AU Boyd, SE Lesko, JJ Case, SW AF Boyd, Steven E. Lesko, John J. Case, Scott W. TI Compression creep rupture behavior of a glass/vinyl ester composite laminate subject to fire loading conditions SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE polymer matrix composites; creep; laminate theory; life prediction; fire ID POLYMER COMPOSITES; STRESS-ANALYSIS; PREDICTION AB The growing use of polymer matrix composites in civil infrastructure, marine and military applications provides the impetus for developing mechanical models to describe their response under combined mechanical and fire loading. A viscoelastic stress analysis using classical lamination theory is conducted on an E-glass/vinyl ester composite. The model includes a characterization of the non-linear thermo-viscoelasticity and its inclusion into a compression strength failure criterion for the prediction of laminate failure under combined compressive load and temperature profile simulating fire exposure. By accounting for the viscoelastic non-linearity at T, the proposed model yields good predictions for lifetimes of the studied composite ([0/+45/90/-45/0](s)). (C) 2007 Elsevier Ltd. All rights reserved. C1 Army Res Lab, AMSRD WMRD WM MC, APG, Aberdeen Proving Ground, MD 21005 USA. Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Mat Res Grp, Blacksburg, VA 24061 USA. RP Boyd, SE (reprint author), Army Res Lab, AMSRD WMRD WM MC, APG, 120 Patton Hall, Aberdeen Proving Ground, MD 21005 USA. EM sboyd@vt.edu; jlesko@vt.edu; scase@vt.edu RI Case, Scott/C-2637-2009; OI Case, Scott/0000-0002-4802-1228 NR 22 TC 10 Z9 10 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD DEC PY 2007 VL 67 IS 15-16 BP 3187 EP 3195 DI 10.1016/j.compscitech.2007.04.009 PG 9 WC Materials Science, Composites SC Materials Science GA 230XV UT WOS:000250910600016 ER PT J AU Russell, K Lee, WT Sodhi, RS AF Russell, Kevin Lee, Wen-Tzong Sodhi, Raj S. TI On the application of CAD technology for the synthesis of spatial revolute-revolute dyads SO COMPUTER-AIDED DESIGN LA English DT Article DE RRSS mechanism; path generation; adjustable mechanisms; spatial mechanisms ID KINEMATIC SYNTHESIS; RRSS MECHANISMS AB This work presents a method based on Computer Aided Design or CAD for facilitating the synthesis of Revolute-Revolute (R-R) dyads with adjustable moving pivots. The CAD-based method presented in this work ensures that all prescribed rigid-body parameters used to synthesize the R-R dyad satisfy particular kinematic requirements of an R-R dyad. Through the application of this CAD method, five of the six general R-R dyad constraint equations are satisfied and therefore not essential for the synthesis of the R-R dyad. By reducing the number of dyad design constraints from six to one, the user can synthesize R-R links with adjustable moving pivots for multi-phase motion and path generation applications. The example included demonstrates the use of the CAD method in the synthesis of an RRSS path generator with adjustable moving pivots. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Russell, Kevin] USA, Ctr Res Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [Lee, Wen-Tzong] Leader Univ, Dept Informat Management, Taiana 70970, Taiwan. [Sodhi, Raj S.] New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. RP Russell, K (reprint author), USA, Ctr Res Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. EM kevin.russell1@us.army.mil NR 10 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0010-4485 J9 COMPUT AIDED DESIGN JI Comput.-Aided Des. PD DEC PY 2007 VL 39 IS 12 BP 1075 EP 1080 DI 10.1016/j.cad.2007.07.004 PG 6 WC Computer Science, Software Engineering SC Computer Science GA 245RO UT WOS:000251953700004 ER PT J AU Batchinsky, AI Moraru, C Jordan, BS Jones, J Cancio, LC Weiss, WB Kuusela, T AF Batchinsky, Andriy I. Moraru, Corina Jordan, Bryan S. Jones, John Cancio, Leopoldo C. Weiss, William B. Kuusela, Tom TI Heart-rate complexity: A new vital sign for diagnosis of trauma and hemorrhage SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Batchinsky, Andriy I.; Moraru, Corina; Jordan, Bryan S.; Jones, John; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Weiss, William B.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [Kuusela, Tom] Univ Turku, SF-20500 Turku, Finland. RI Necsoiu, Corina/A-6255-2013 NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 273 BP A71 EP A71 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398900245 ER PT J AU Dubick, MA Scherer, MR Fedyk, CG Delgado, AV Kheirabadi, BS AF Dubick, Michael A. Scherer, Michael R. Fedyk, Chriselda G. Delgado, Angel V. Kheirabadi, Bijan S. TI The efficacy of recombinant activated factor VII (RFVIIA) on hemodiluted and hypothermic human blood in vitro SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Dubick, Michael A.; Scherer, Michael R.; Fedyk, Chriselda G.; Delgado, Angel V.; Kheirabadi, Bijan S.] US Army Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 250 BP A64 EP A64 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398900224 ER PT J AU Gabrielli, A Hayes, RL Wishin, J Layon, AJ Robicsek, S Wang, KW Oli, MW Robinson, G Tortella, F AF Gabrielli, Andrea Hayes, Ronald L. Wishin, J. Layon, A. J. Robicsek, Steven Wang, Kevin W. Oli, Monika W. Robinson, Gillian Tortella, F. TI Novel biofluid-based protein biomarkers and physiological trends in severe traumatic brain injury SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Gabrielli, Andrea; Hayes, Ronald L.; Wishin, J.; Layon, A. J.; Robicsek, Steven] Univ Florida, Dept Anesthesiol, Gainesville, FL 32611 USA. [Wang, Kevin W.] Univ Florida, Dept Neurosci & Psychiat, Gainesville, FL 32611 USA. [Oli, Monika W.; Robinson, Gillian] Banyan Biomakers Inc, Alachua, FL USA. [Tortella, F.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 174 BP A41 EP A41 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398900147 ER PT J AU Helman, DL Jackson, WL Shorr, AF AF Helman, Donald L. Jackson, William L. Shorr, Andrew F. TI Oral decontamination with chlorhexidine reduces ventilator associated pneumonia due to gram positive but not gram negative pathogens. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Helman, Donald L.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Jackson, William L.] Hlth First Inc, Rockledge, FL USA. [Shorr, Andrew F.] Washington Hosp Ctr, Washington, DC 20010 USA. NR 0 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 954 BP A266 EP A266 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398901425 ER PT J AU Helman, DL Ramage, AS Shorr, AF AF Helman, Donald L. Ramage, Anthony S. Shorr, Andrew F. TI Oral decontamination with chlorhexidine for the prevention of ventilator associated pneumonia: Assessment of methodological trial quality. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Helman, Donald L.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Ramage, Anthony S.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Shorr, Andrew F.] Washington Hosp Ctr, Washington, DC 20010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 944 BP A264 EP A264 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398901416 ER PT J AU Lundy, JB Chung, KK Wolf, SE Renzo, IM Barillo, DJ Mann, EA Cancio, LC AF Lundy, Jonathan B. Chung, Kevin K. Wolf, Steven E. Renzo, Ivan M. Barillo, David J. Mann, Elizabeth A. Cancio, Leopoldo C. TI Continuous renal replacement therapy improves mortality in severely burned patients with acute kidney injury SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Lundy, Jonathan B.; Chung, Kevin K.; Wolf, Steven E.; Renzo, Ivan M.; Barillo, David J.; Mann, Elizabeth A.; Cancio, Leopoldo C.] Brooke Army Med Ctr, Inst Surg Res, Cibolo, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 872 BP A241 EP A241 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398901344 ER PT J AU Mann, E Pidcoke, H Salinas, J Holcomb, J Wade, C Wolf, S AF Mann, Elizabeth Pidcoke, Heather Salinas, Jose Holcomb, John Wade, Charles Wolf, Steven TI Hematocrit effect outweighs other sources of glucometer error in critical care SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Mann, Elizabeth; Pidcoke, Heather; Salinas, Jose; Holcomb, John; Wade, Charles; Wolf, Steven] USA, Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 511 BP A140 EP A140 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398900491 ER PT J AU Spindella, PC Perkins, J Grathwohl, K Beekley, A Wade, C Holcomb, JB AF Spindella, Philip C. Perkins, Jeremy Grathwohl, Kurt Beekley, Alec Wade, Charles Holcomb, John B. TI Effect of blood products transfused on survival for patients with combat related traumatic injuries SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Spindella, Philip C.] CCMC, Hartford, CT USA. [Perkins, Jeremy; Grathwohl, Kurt; Beekley, Alec; Wade, Charles; Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 66 BP A17 EP A17 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398900068 ER PT J AU Tabaku, L AF Tabaku, Lindita TI Evaluation of swine as a translational animal model in hemorrhagic shock. Lindita Tabaku, Stephen Van Albert, Alison Garcia and Frederick J. Pearce. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 37th Critical Care Congress of the Society-of-Critical-Care-Medicine CY FEB 02-08, 2008 CL Honolulu, HI SP Soc Crit Care Med C1 [Tabaku, Lindita] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2007 VL 35 IS 12 SU S MA 137 BP A30 EP A30 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 237TI UT WOS:000251398900111 ER PT J AU Lewis, JS Ellis, MW AF Lewis, James S., II Ellis, Michael W. TI Approaches to serious methicillin-resistant Staphylococcus aureus infections with decreased susceptibility to vancomycin: clinical significance and options for management SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Review DE accessory gene regulator (agr); methicillin-resistant Staphylococcus aureus; vancomycin-intermediate Staphylococcus aureus ID SOFT-TISSUE INFECTIONS; AORTIC-VALVE ENDOCARDITIS; ONCE-WEEKLY DALBAVANCIN; REDUCED SUSCEPTIBILITY; RABBIT MODEL; IN-VITRO; TRIMETHOPRIM-SULFAMETHOXAZOLE; BACTERICIDAL ACTIVITY; DAPTOMYCIN-RESISTANT; COMPLICATED SKIN AB Purpose of review This review addresses therapeutic approaches to Staphylococcus aureus infections with diminished susceptibility to vancomycin, focusing on recently published data in English language medical literature between June 2006 and July 2007. Recent findings Knowledge regarding the potential limitations of vancomycin therapy for S. aureus infections continues to emerge. Recent changes include alteration of the Clinical Laboratory and Standards Institute vancomycin breakpoint for S. aureus and questions regarding the utility of the lower breakpoint of 2.0 mg/l. Interest continues in the accessory gene regulator (agr) locus and its impact on the activity of vancomycin. Newer options for drug therapy progress, with strengths and limitations becoming more apparent for each. Summary Newer antimicrobial agents active against methicillin-resistant S. aureus such as daptomycin and linezolid continue to show value. Older antimicrobial agents may play an important therapeutic role and warrant further examination. Work is needed to evaluate current agents against methicillin-resistant S. aureus in the setting of elevated vancomycin minimum inhibitory concentrations or clinical failure. Antimicrobial selection for methicillin-resistant S. aureus infections with reduced susceptibility to vancomycin should be governed by disease severity, susceptibility patterns, knowledge of the limitations of current susceptibility testing, and strengths and weaknesses of the agents being considered. C1 Univ Hlth Syst, Dept Pharm, San Antonio, TX 78229 USA. Univ Texas Hlth Sci Ctr, Dept Med, Div Infect Dis, San Antonio, TX USA. Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, Ft Sam Houston, TX 78234 USA. RP Lewis, JS (reprint author), Univ Hlth Syst, Dept Pharm, 4502 Med Dr, San Antonio, TX 78229 USA. EM james.lewis@uhs-sa.com NR 54 TC 8 Z9 9 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD DEC PY 2007 VL 20 IS 6 BP 568 EP 573 PG 6 WC Infectious Diseases SC Infectious Diseases GA 237QJ UT WOS:000251390500002 PM 17975405 ER PT J AU Green, CPTB Sparling, MAJJ Sparling, MB AF Green, C. P. T. Brian Sparling, M. A. J. Joshua Sparling, Molly B. TI What's eating you? Pigeon mite (Dermanyssus gallinae) SO CUTIS LA English DT Article ID INFESTATION; DERMATITIS; BITES; ACARI C1 [Green, C. P. T. Brian] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. [Sparling, M. A. J. Joshua; Sparling, Molly B.] Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. RP Green, CPTB (reprint author), 3100 Thurston Bowles Bldg,CB 7287, Chapel Hill, NC 27599 USA. EM bpgreen47@yahoo.com NR 8 TC 3 Z9 3 U1 1 U2 3 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD DEC PY 2007 VL 80 IS 6 BP 461 EP 462 PG 2 WC Dermatology SC Dermatology GA 245DF UT WOS:000251914300002 ER PT J AU Yun, HC Ellis, MW Jorgensen, JH AF Yun, Heather C. Ellis, Michael W. Jorgensen, James H. TI Activity of ceftobiprole against community-associated methicillin-resistant Staphylococcus aureus isolates recently recovered from US military trainees SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE ceftobiprole; MRSA; CA-MRSA; military ID BROAD-SPECTRUM CEPHALOSPORIN; IN-VIVO; BETA-LACTAMS; VANCOMYCIN; INFECTION; COLONIZATION; ENDOCARDITIS; TIGECYCLINE; DAPTOMYCIN; RO-63-9141 AB Ceftobiprole MICs at which 50% and 90% of isolates were inhibited (MIC50 and MIC90), determined by the Clinical and Laboratory Standards Institute broth microdilution method, were both 1 mu g/mL (range, 0.5-1 mu g/mL) against 143 community-associated methicillin-resistant Staphylococcus aureus isolates and 0.5 mu g/mL (range, 0.25-0.5 mu g/mL) with 29 methicillin-susceptible isolates recovered from military trainees during 2 prospective investigations. (c) 2007 Elsevier Inc. All rights reserved. C1 [Yun, Heather C.; Ellis, Michael W.] Brooke Army Med Ctr, MCHE MDI, Infect Dis Serv, Dept Med Infect Dis, Ft Sam Houston, TX 78234 USA. [Yun, Heather C.] Wilford Hall USAF Med Ctr, Dept Infect Dis, Lackland AFB, TX 78236 USA. [Jorgensen, James H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. RP Yun, HC (reprint author), Brooke Army Med Ctr, MCHE MDI, Infect Dis Serv, Dept Med Infect Dis, Ft Sam Houston, TX 78234 USA. EM heather.yun@amedd.army.mil NR 32 TC 10 Z9 11 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD DEC PY 2007 VL 59 IS 4 BP 463 EP 466 DI 10.1016/j.diagmicrobio.2007.06.023 PG 4 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 243PK UT WOS:000251809600018 PM 17911001 ER PT J AU Gertner, G Wang, G Anderson, AB Howard, H AF Gertner, George Wang, Guangxing Anderson, Alan B. Howard, Heidi TI Combining stratification and up-scaling method-block cokriging with remote sensing imagery for sampling and mapping an erosion cover factor SO ECOLOGICAL INFORMATICS LA English DT Article DE block-cokriging; mapping; remote sensing; sample design; scaling AB When a ground and vegetation cover factor related to soil erosion is mapped with the aid of remotely sensed data, a cost-efficient sample design to collect ground data and to obtain an accurate map is required. However, the supports used to collect ground data are often smaller than the desirable pixels used for mapping, which leads to complexity in developing procedures for sample design and mapping. For these purposes, a sampling and mapping method was developed by integrating stratification and an up-scaling method in geostatistics - block cokriging with Landsat Thematic Mapper imagery. This method is based on spatial correlation and stratified sampling. It scales up not only the ground sample data but also the uncertainties associated with the data aggregation from smaller supports to larger pixels or blocks. This method uses the advantages of both stratification and block cokriging variance-based sample design, which leads to sample designs with variable grid spacing, and thus significantly increases the unit cost-efficiency of sample data in sampling and mapping. This outcome was verified by the results of this study. (c) 2007 Elsevier B.V. All rights reserved. C1 [Gertner, George; Wang, Guangxing] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Anderson, Alan B.; Howard, Heidi] Construct Engn Res Lab, Champaign, IL 61826 USA. RP Gertner, G (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@uiuc.edu NR 25 TC 6 Z9 7 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1574-9541 J9 ECOL INFORM JI Ecol. Inform. PD DEC PY 2007 VL 2 IS 4 BP 373 EP 386 DI 10.1016/j.ecoinf.2007.06.002 PG 14 WC Ecology SC Environmental Sciences & Ecology GA 247EV UT WOS:000252061200009 ER PT J AU Gleason, SM Faucette, DT Toyofuku, MM Torres, CA Bagley, CF AF Gleason, Sean M. Faucette, Dave T. Toyofuku, Mai M. Torres, Carlos A. Bagley, Calvin F. TI Assessing and mitigating the effects of windblown soil on rare and common vegetation SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE wind erosion; resource management; rare plants; photosynthesis; wamax; Endangered Species Act ID WIND EROSION; PHYSIOLOGICAL-RESPONSES; MOJAVE DESERT; FIELD; PARTICLES; LOSSES; HEALTH AB Acting under the auspices of the US Endangered Species Act, we quantified wind erosion and its effects on rare and common plant species on a semi-arid military installation in Hawaii. Our goal was to develop management strategies, based on local data, to aid the conservation of rare and common indigenous plants and their habitats. We collected windblown soil coming off of roads and other disturbed soils to assess likely impacts to plants occurring at certain heights and distances from disturbed surfaces. We then subjected plants in a glasshouse to windblown dust treatments, designed from our field data to simulate erosion events, and evaluated the effect of these treatments on photosynthesis and survival. We also designed several field experiments to examine the in-situ effects of windblown soil and soil substrate on germination, growth rate, and survival of indigenous and nonindigenous plants. We conclude from these experiments that most direct effects of windblown soil to plants can be effectively mitigated by locating roads and training areas at least 40 m from sensitive plant habitats and through vegetation management to maintain at least 11% aerial cover on disturbed surfaces. Effects of soil type on germination, growth, and survival was species-specific, emphasizing the importance of species trials prior to, or during, rehabilitation efforts. C1 US Army Garrison, Directorate Publ Works, Pohakuloa Training Area, Environm Div, Hilo, HI 96720 USA. Colorado State Univ, CEMML, Ft Collins, CO 80523 USA. RP Gleason, SM (reprint author), Monash Univ, Sch Biol Sci, Clayton, Vic 3800, Australia. EM sean.gleason@sci.monash.edu.au NR 27 TC 2 Z9 2 U1 1 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X EI 1432-1009 J9 ENVIRON MANAGE JI Environ. Manage. PD DEC PY 2007 VL 40 IS 6 BP 1016 EP 1024 DI 10.1007/s00267-007-9004-3 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 235HQ UT WOS:000251224800017 PM 17726626 ER PT J AU Gong, P Guan, X Inouye, LS Pirooznia, M Indest, KJ Athow, RS Deng, YP Perkins, EJ AF Gong, Ping Guan, Xin Inouye, Laura S. Pirooznia, Mehdi Indest, Karl J. Athow, Rebecca S. Deng, Youping Perkins, Edward J. TI Toxicogenomic analysis provides new insights into molecular mechanisms of the sublethal toxicity of 2,4,6-trinitrotoluene in Eisenia fetida SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID OXIDATIVE STRESS; NITROAROMATIC EXPLOSIVES; ENERGETIC COMPOUNDS; ELECTRON REDUCTION; IMMUNE-RESPONSES; GENE-EXPRESSION; INNATE IMMUNITY; PROTEIN; ENZYME; CHITOTRIOSIDASE AB Xenobiotics such as explosives and pesticides released into the environment can have lethal and sublethal impacts on soil organisms such as earthworms with potential subsequent impacts at higher trophic levels. To better understand the molecular toxicological mechanisms of 2,4,6-trinitrotoluene (TNT), a commonly used explosive, in Eisenia fetida, earthworms were exposed to a gradient of TNT-spiked soils for 28 days and impacts on gene expression were examined using a 4032 cDNA microarray. Reproduction was increased at low doses of TNT, whereas high doses of TNT reduced juvenile production. On the basis of reproduction responses to TNT, four treatments, that is, control, 2, 10.6, and 38.7 mg/kg, were selected for gene expression studies in a balanced interwoven loop design microarray experiment in which the expression of 311 transcripts was significantly affected. Reverse-transcription quantitative polymerase chain reaction (RT-QPCR) data on 68 selected differentially and nondifferentially expressed transcripts showed a significant correlation with microarray results. The expression of genes involved in multiple biological processes was altered, including muscle contraction, neuronal signaling and growth, ubiquitinylation, fibrinolysis and coagulation, iron and calcium homeostasis, oxygen transport, and immunity. Chitinase activity assays confirmed down-regulation of chitinase genes as indicated by array and RT-QPCR data. An acute toxicity test provided evidence that dermal contact with TNT can cause bleeding, inflammation, and constriction, which may be explained by gene expression results. Sublethal doses of TNT affected the nervous system, caused blood disorders similar to methemoglobinemia, and weakened immunity in E fetida. C1 SpecPro Inc, Vicksburg, MS 39180 USA. USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. RP Gong, P (reprint author), SpecPro Inc, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ping.gong@us.army.mil OI Pirooznia, Mehdi/0000-0002-4210-6458 NR 54 TC 35 Z9 36 U1 0 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 1 PY 2007 VL 41 IS 23 BP 8195 EP 8202 DI 10.1021/es0716352 PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 236LW UT WOS:000251305500042 PM 18186358 ER PT J AU Koterski, J Twenhafel, N Porter, A Reed, DS Martino-Catt, S Sobral, B Crasta, O Downey, T DaSilva, L AF Koterski, James Twenhafel, Nancy Porter, Aimee Reed, Douglas S. Martino-Catt, Susan Sobral, Bruno Crasta, Oswald Downey, Thomas DaSilva, Luis TI Gene expression profiling of nonhuman primates exposed to aerosolized Venezuelan equine encephalitis virus SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY LA English DT Article DE Venezuelan equine encephalitis virus; cynomolgus macaque (Macaca fascicularis); aerosol; gene expression; microarray ID VESICULAR STOMATITIS-VIRUS; CENTRAL-NERVOUS-SYSTEM; MACACA-RHESUS MONKEYS; ENCEPHALOMYELITIS VIRUS; RESPIRATORY TRACT; HUMAN MACROPHAGES; OLFACTORY ROUTE; BALB/C MICE; WILD-TYPE; INFECTION AB Host responses to Venezuelan equine encephalitis viruses (VEEV) were studied in cynomolgus macaques after aerosol exposure to the epizootic virus. Changes in global gene expression were assessed for the brain, lungs, and spleen. In the brain, major histocompatibility complex (MHC) class I transcripts were induced, while the expression of S100b, a factor associated with brain injury, was inhibited, as was expression of the encephalitogenic gene MOG. Cytokine-mediated signals were affected by infection, including those involving IFN-mediated antiviral activity (IRF-7, OAS, and Mx transcripts), and the increased transcription of caspases. Induction of a few immunologically relevant genes (e.g. IFITM1 and STAT1) was common to all tested tissues. Herein, both tissue-specific and nontissue specific transcriptional changes in response to VEEV are described, including induction of IFN-regulated transcripts and cytokine-induced apoptotic factors, in addition to cellular factors in the brain that may be descriptive of the health status of the brain during the infectious process. Altogether, this work provides novel information on common and tissue-specific host responses against VEEV in a nonhuman primate model of aerosol exposure. C1 USA, Med Res Inst Infect Dis, Frederick, MD USA. Virginia Bioinformat Inst, Bioinformat Facil 1, Blacksburg, VA USA. Partek Inc, St Louis, MO USA. RP DaSilva, L (reprint author), USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, 1425 Porter Str, Fort Detrick, Frederick, MD 21702 USA. EM luis.dasilva@amedd.army.mil OI Reed, Douglas/0000-0003-0076-9023 NR 43 TC 13 Z9 13 U1 0 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0928-8244 J9 FEMS IMMUNOL MED MIC JI FEMS Immunol. Med. Microbiol. PD DEC PY 2007 VL 51 IS 3 BP 462 EP 472 DI 10.1111/j.1574-695X.2007.00319.x PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 228VU UT WOS:000250761500003 PM 17894805 ER PT J AU DeShazer, D AF DeShazer, David TI Virulence of clinical and environmental isolates of Burkholderia oklahomensis and Burkholderia thailandensis in hamsters and mice SO FEMS MICROBIOLOGY LETTERS LA English DT Article DE Burkholderia oklahomensis; Burkholderia thailandensis; Burkholderia pseudomallei ID PSEUDOMONAS-PSEUDOMALLEI; SECRETION SYSTEM; MELIOIDOSIS; INFECTION; ARA(+); DIFFERENTIATION; DISCRIMINATION; IDENTIFICATION; NONVIRULENT; PATHOGEN AB Burkholderia pseudomallei is the etiologic agent of the tropical disease melioidosis and is considered to be a potential biological weapon. Two B. pseudomallei-like species, Burkholderia oklahomensis and Burkholderia thailandensis, have been described in the literature. Infections with both of these microorganisms have occurred in the United States, but little is known about the relative virulence of these isolates in animal models of infection. In this study, B. oklahomensis and B. thailandensis CDC2721121 were determined to be avirulent in hamsters and mice at all challenge doses examined. The virulence of B. thailandensis CDC3015869, on the other hand, was more similar to the virulence of isolates of B. thailandensis from Southeast Asia. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP DeShazer, D (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM david.deshazer@amedd.army.mil NR 31 TC 20 Z9 21 U1 0 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0378-1097 J9 FEMS MICROBIOL LETT JI FEMS Microbiol. Lett. PD DEC PY 2007 VL 277 IS 1 BP 64 EP 69 DI 10.1111/j.1574-6968.2007.00946.x PG 6 WC Microbiology SC Microbiology GA 226WM UT WOS:000250619200009 PM 17986086 ER PT J AU Armbruster, S Dorrance, C Voorhees, P Pingpank, JF Kurland, JE AF Armbruster, Steven Dorrance, Colleen Voorhees, Patrick Pingpank, James F. Kurland, Jayde E. TI Malignant insulinoma: a rare presentation of a rare tumor SO GASTROINTESTINAL ENDOSCOPY LA English DT Editorial Material C1 [Armbruster, Steven; Dorrance, Colleen; Kurland, Jayde E.] Natl Naval Med Ctr, Dept Gastroenterol, Dept Internal Med & Oncol, Bethesda, MD 20889 USA. [Voorhees, Patrick] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Pingpank, James F.] NCI, Surg Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. RP Armbruster, S (reprint author), Natl Naval Med Ctr, Dept Gastroenterol, Dept Internal Med & Oncol, Bethesda, MD 20889 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD DEC PY 2007 VL 66 IS 6 BP 1228 EP 1229 DI 10.1016/j.gie.2007.06.026 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 241PZ UT WOS:000251669600030 PM 17719587 ER PT J AU Harrison, SA Day, CP AF Harrison, Stephen A. Day, Christopher Paul TI Benefits of lifestyle modification in NAFLD SO GUT LA English DT Article ID FATTY LIVER-DISEASE; ACTIVATED PROTEIN-KINASE; HEPATIC INSULIN-RESISTANCE; PLACEBO-CONTROLLED TRIAL; ELEMENT-BINDING PROTEIN; SEVERELY OBESE SUBJECTS; WEIGHT-LOSS; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME; SKELETAL-MUSCLE C1 Univ Newcastle Upon Tyne, Sch Med, Inst Cellular Med, Liver Res Grp,Sch Clin Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Houston, TX USA. RP Day, CP (reprint author), Univ Newcastle Upon Tyne, Sch Med, Inst Cellular Med, Liver Res Grp,Sch Clin Med Sci, Floor 4,William Beech Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. EM c.p.day@ncl.ac.uk NR 88 TC 118 Z9 120 U1 0 U2 4 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0017-5749 J9 GUT JI Gut PD DEC PY 2007 VL 56 IS 12 BP 1760 EP 1769 DI 10.1136/gut.2006.112094 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 230SB UT WOS:000250895100027 PM 17911352 ER PT J AU Vernieuw, CR Stephenson, LA Kolka, MA AF Vernieuw, Carrie R. Stephenson, Lou A. Kolka, Margaret A. TI Thermal comfort and sensation in men wearing a cooling system controlled by skin temperature SO HUMAN FACTORS LA English DT Article ID RESPONSES AB Objective: The study was done to determine whether thermal comfort (TC), thermal sensation (TS), and subjective factors gauging environmental stress were negatively affected with different cooling methods in men exercising in chemical protective clothing. Background: Previous studies have reported that intermittent regional cooling improved the efficacy of cooling as compared with constant cooling (CC), but no studies have addressed whether there is any improvement in thermal comfort. Methods: Eight male volunteers exercised at moderate work intensity (425 W) in three microclimate cooling tests. The circulating fluid in the cooling garment was provided during exercise to the head (6% body surface area [BSA]), torso (22% BSA), and thighs (44% BSA) and manipulated under three methods: (a) CC, (b) pulsed cooling (PC), and (c) PC activated by mean skin temperature ((T) over bar (sk)) control (PCskin). TC and TS ratings were recorded every 20 min during the 80-min test. Results: TC and TS ratings were not different for PCskin and CC; thus the participants perceived PCskin as being similar to CC. TS was significantly warmer with PC than with PCskin and CC (p <.001). In PCskin, <(T)over bar>(sk) was significantly higher than in PC and CC (p <.001), and PCskin was rated as being not as warm as PC according to TS. Conclusion: This indicates that the PCskin method was perceived as being as cool as CC and cooler than PC. Application: These findings indicate that the PCskin cooling method is an acceptable alternative to CC and PC based on human perceptions. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Vernieuw, CR (reprint author), USA, Environm Med Res Inst, 15 Kansas St,BLDG 42, Natick, MA 01760 USA. EM carrie.vemieuw@gmail.com NR 12 TC 7 Z9 7 U1 1 U2 6 PU HUMAN FACTORS SOC PI SANTA MONICA PA BOX 1369, SANTA MONICA, CA 90406 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD DEC PY 2007 VL 49 IS 6 BP 1033 EP 1044 DI 10.1518/001872007X249893 PG 12 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 232UC UT WOS:000251044200006 PM 18074702 ER PT J AU Polcawich, RG Pulskamp, JS Judy, D Ranade, P Trolier-McKinstry, S Dubey, M AF Polcawich, Ronald G. Pulskamp, Jeffrey S. Judy, Daniel Ranade, Prashant Trolier-McKinstry, Susan Dubey, Madan TI Surface micromachined microelectromechancial ohmic series switch using thin-film piezoelectric actuators SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE lead zirconate titanate (PZT); piezoelectric; reliability; RF microelectromechanical system (MEMS); switch; switching speed; temperature sensitivity ID MEMS SWITCHES; OPERATION; BEHAVIOR; DESIGN AB This paper presents results on a surface micromachined RF microelectromechanical switch that uses piezoelectric actuators. The switch uses solution chemistry-derived lead zirconate titanate thin films spun deposited onto a high-resistivity silicon substrate with coplanar waveguide transmission lines. Actuation voltages, applied via circuits independent of the RF circuitry, average less than 10 V, with switch operation demonstrated as low as 2 V. The series switch exhibits better than 20-dB isolation from dc up to 65 GHz and as large as 70 dB below 1 GHz. In the closed state, the switch has an insertion loss less than 1 dB up to 40 GHz, limited in this demonstration by substrate losses from the elastic layer used to stress control the piezoelectric actuators. Switching speeds for the different designs are in the range of 40-60 ms. Thermal sensitivity measurements show no change in isolation observed for temperatures up to 125 degrees C. However, an increase in actuation voltage is required at elevated temperatures. C1 [Polcawich, Ronald G.; Pulskamp, Jeffrey S.] USA, Res Lab, Adelphi Lab Ctr, Adv MicroDevices Branch, Adelphi, MD 20783 USA. [Polcawich, Ronald G.; Trolier-McKinstry, Susan] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. RP Polcawich, RG (reprint author), USA, Res Lab, Adelphi Lab Ctr, Adv MicroDevices Branch, Adelphi, MD 20783 USA. EM rpolcawich@arl.army.mil; STMcKinstry@psu.edu NR 26 TC 58 Z9 58 U1 1 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD DEC PY 2007 VL 55 IS 12 BP 2642 EP 2654 DI 10.1109/TMTT.2007.910072 PN 1 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 242IN UT WOS:000251718900021 ER PT J AU Dong, M Tong, L Sadler, BM AF Dong, Min Tong, Lang Sadler, Brian M. TI Information retrieval and processing in sensor networks: Deterministic scheduling versus random access SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE estimation; information retrieval; random access; random field; sampling; scheduling; sensor network ID POLYNOMIAL INTERPOLATION AB We investigate the effect of medium-access control (MAC) used in information retrieval by a mobile access point (AP) on information processing in large-scale sensor network, where sensors are unreliable and subject to outage. We focus on a 1-D sensor network and assume that the location information is available locally at each sensor and unavailable to the AP. For a fixed collection interval, two types of MAC schemes are considered: the deterministic scheduling, which collects data from predetermined sensors locations, and random access, which collects data from random locations. We compare the signal estimation performance of the two MACs,, using the expected maximum distortion as the performance measure. For large sensor networks with fixed density, we show that there is a critical threshold on the sensor outage probability P-out: For P-out < e-lambda(1+o(1)), where lambda is the throughput of the random access protocol, the deterministic scheduling provides better reconstruction performance. However, for P-out > e-lambda(1+o(1)), the performance degradation from missing data samples due to sensor outage does not justify the effort of scheduling; simple random access outperforms the optimal scheduling. C1 Qulacomm Inc, Corp Res & Dev, San Diego, CA 92121 USA. Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Dong, M (reprint author), Qulacomm Inc, Corp Res & Dev, San Diego, CA 92121 USA. EM mdong@qualcomm.com; ltong@ece.comell.edu; bsadler@arl.army.mil NR 29 TC 9 Z9 9 U1 3 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD DEC PY 2007 VL 55 IS 12 BP 5806 EP 5820 DI 10.1109/TSP.2007.897911 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA 238OH UT WOS:000251456600022 ER PT J AU Guo, N Sadler, BM Qiu, RC AF Guo, Nan Sadler, Brian M. Qiu, Robert C. TI Reduced-complexity UWB time-reversal techniques and experimental results SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE time reversal; ultra-wideband (UWB); autocorrelation correlation demodulation (ACD); multiple antennas ID MULTIPLE-ACCESS COMMUNICATIONS; ULTRA-WIDE-BAND; ULTRAWIDEBAND COMMUNICATIONS; RECEIVERS AB This paper presents a reduced-complexity time reversal technique for ultra-wideband (UWB) communications. Time reversal takes advantage of rich scattering environments to achieve signal focusing via transmitter-side processing, which enables the use of simple receivers. The goal of this paper is to demonstrate a UWB time reversal system architecture based on experimental results and practical pulse waveform, taking into account some practical constraints, and to show feasibility of UWB time reversal. Pre-decorrelating in addition to time reversal processing is considered for a downlink multiuser configuration. Multiple transmit antennas are employed to improve the performance. C1 [Guo, Nan; Qiu, Robert C.] Tennessee Technol Univ, Ctr Mfg Res, Cookeville, TN 38505 USA. [Qiu, Robert C.] Tennessee Technol Univ, Dept Elect & Comp Engn, Cookeville, TN 38505 USA. [Sadler, Brian M.] USA, Res Lab, AMSRD ARL CI CN, Adelphi, MD 20783 USA. RP Guo, N (reprint author), Tennessee Technol Univ, Ctr Mfg Res, Cookeville, TN 38505 USA. EM nguo@tntech.edu; bsadler@arl.army.mil; rqiu@tntech.edu NR 14 TC 49 Z9 50 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD DEC PY 2007 VL 6 IS 12 BP 4221 EP 4226 DI 10.1109/TWC.2007.060251 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 242RT UT WOS:000251744000006 ER PT J AU Margetts, AR Schniter, P Swami, A AF Margetts, Adam R. Schniter, Philip Swami, Ananthram TI Joint scale-lag diversity in wideband mobile direct sequence spread spectrum systems SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article; Proceedings Paper CT 30th IEEE International Conference on Acoustics, Speech, and Signal Processing CY MAR 19-23, 2005 CL Philadelphia, PA SP IEEE DE mobile wireless communication; scale-lag diversity; spread spectrum; wideband systems ID RADAR; PERFORMANCE; WAVELETS; RADIO; UWB AB We consider the effect of mobility on a wideband direct sequence spread spectrum (DSSS) communication system, and study a scale-lag Rake receiver capable of leveraging the diversity that results from mobility. A wideband signal has a large bandwidth-to-center frequency ratio, such that the typical narrowband Doppler spread assumptions do not apply to mobile channels. Instead, we assume a more general temporal scaling phenomenon, i.e., a dilation of the transmitted signal's time support. Based on a uniform ring of scatterers model, we determine that the wideband scattering function, which quantifies the average scale spreading, has a "bathtub-shaped" scale profile. We compare the performances of a scale-lag Rake and a frequency-lag Rake, each capable of leveraging the diversity that results from mobility. Such analysis applies, for example, to ultra-wideband (UWB) radio frequency channels and underwater wideband acoustic channels. C1 [Margetts, Adam R.] MIT, Lincoln Lab, Lexington, MA 02420 USA. [Schniter, Philip] Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Margetts, AR (reprint author), MIT, Lincoln Lab, 244 Wood St, Lexington, MA 02420 USA. EM margetts@ieee.org; schniter@ece.osu.edu; a.swami@ieee.org RI Schniter, Philip/A-7336-2012 NR 37 TC 15 Z9 15 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD DEC PY 2007 VL 6 IS 12 BP 4308 EP 4319 DI 10.1109/TWC.2007.05141 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 242RT UT WOS:000251744000019 ER PT J AU Kaushal, DC Kaushal, NA Narula, A Kumar, N Puri, SK Dutta, S Lanar, DE AF Kaushal, Deep C. Kaushal, Nuzhat A. Narula, Atul Kumar, Niraj Puri, S. K. Dutta, Shitij Lanar, David E. TI Biochemical and immunological characterization of E-coli expressed 42 kDa fragment of Plasmodium vivax and P-cynomolgi bastianelli merozoite surface protein-1 SO INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS LA English DT Article DE plasmodium vivax; plasmodium cynomolgi; malaria; vaccine; merozoite surface protein-1; merozoite; rhesus monkey ID AOTUS MONKEYS; TERMINAL FRAGMENT; SEQUENCE-ANALYSIS; IMMUNE-RESPONSE; BINDING-PROTEIN; PICHIA-PASTORIS; RHESUS-MONKEYS; CELL INVASION; MALARIA; FALCIPARUM AB Plasmodium vivax is one of the most widely distributed human malaria parasites and due to drug-resistant strains, its incidence and prevalence has increased, thus an effective vaccine against the parasites is urgently needed. One of the major constraints in developing P: vivax vaccine is the lack of suitable in vivo models for testing the protective efficacy of the vaccine. P. vivax and P. cynomolgi bastianelli are the two closely related malaria parasites and share a similar clinical course of infection in their respective hosts. The merozoite surface protein-1 (MSP-1) of these parasites has found to be protective in a wide range of host-parasite systems. P. vivax MSP-1 is synthesized as 200 kDa polypeptide and processed just prior to merozoite release from the erythrocytes into smaller fragments. The C-terminal 42 kDa cleavage product of MSP-1 (MSP-I-42,) is present on the surface of merozoites and a major candidate for blood stage malaria vaccine. In the present study, we have biochemically and immunologically characterized the soluble and refolded 42 kDa fragment of MSP-1 of P. vivax (PvMSP-I-42) and P.cynomolgi (PCMSP-I-42). SDS-PAGE analysis showed that both soluble and refolded E. coli expressed P. vivax and P. cynomolgi B MSP-I-42 proteins were homogenous in nature. The soluble and refolded MSP-I-42 antigens of both parasites showed high reactivity with protective monkey sera and conformation-specific monoclonal antibodies against P. cynomolgi B and P. vivax MSP-I-42 antigens. Immunization of BALB/c mice with these antigens resulted in the production of high titres of cross-reactive antibodies primarily against the conformational epitopes of MSP-I-42 protein. The immune sera from rhesus monkeys, immunized with soluble and refolded MSP-I-42 antigens of both parasites also showed high titered cross-reactive antibodies against MSP-I-42 conformational epitopes. These results suggested that the soluble and refolded forms of E. coli expressed P. vivax MSP-I-42 antigens were highly immunogenic and thus a viable candidate for vaccine studies. C1 [Kaushal, Deep C.; Narula, Atul; Kumar, Niraj] Cent Drug Res Inst, Div Microbiol, Lucknow 226001, Uttar Pradesh, India. [Kaushal, Nuzhat A.; Puri, S. K.] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India. [Dutta, Shitij; Lanar, David E.] Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. RP Kaushal, DC (reprint author), Cent Drug Res Inst, Div Microbiol, POB 173, Lucknow 226001, Uttar Pradesh, India. EM deepkaushal@hotmail.com RI Lanar, David/B-3560-2011 NR 47 TC 6 Z9 6 U1 0 U2 0 PU NATL INST SCIENCE COMMUNICATION-NISCAIR PI NEW DELHI PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA SN 0301-1208 EI 0975-0959 J9 INDIAN J BIOCHEM BIO JI Indian J. Biochem. Biophys. PD DEC PY 2007 VL 44 IS 6 BP 429 EP 436 PG 8 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 262GT UT WOS:000253137700002 PM 18320841 ER PT J AU Kuramochi, M Karypis, G AF Kuramochi, Michihiro Karypis, George TI Discovering frequent geometric subgraphs SO INFORMATION SYSTEMS LA English DT Article DE graph mining; pattern discovery; geometric subgraphs ID ALGORITHM; PATTERNS; ASSOCIATION; GRAPHS AB Data mining-based analysis methods are increasingly being applied to data sets derived from science and engineering domains that model various physical phenomena and objects. In many of these data sets, a key requirement for their effective analysis is the ability to capture the relational and geometric characteristics of the underlying entities and objects. Geometric graphs, by modeling the various physical entities and their relationships with vertices and edges, provide a natural method to represent such data sets. In this paper we present gFSG, a computationally efficient algorithm for finding frequent patterns corresponding to geometric subgraphs in a large collection of geometric graphs. gFSG is able to discover geometric subgraphs that can be rotation, scaling, and translation invariant, and it can accommodate inherent errors on the coordinates of the vertices. We evaluated its performance using a large database of over 20,000 chemical structures, and our results show that it requires relatively little time, can accommodate low support values, and scales linearly with the number of transactions. (C) 2007 Elsevier B.V. All rights reserved. C1 Univ Minnesota, Dept Comp Sci Engn, Digital Technol Ctr, Minneapolis, MN 55455 USA. Univ Minnesota, Army HPC Res Ctr, Minneapolis, MN 55455 USA. RP Karypis, G (reprint author), Univ Minnesota, Dept Comp Sci Engn, Digital Technol Ctr, Minneapolis, MN 55455 USA. EM kuram@cs.umn.edu; karypis@cs.umn.edu RI Cong , Gao/A-3726-2011 NR 54 TC 10 Z9 10 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4379 EI 1873-6076 J9 INFORM SYST JI Inf. Syst. PD DEC PY 2007 VL 32 IS 8 BP 1101 EP 1120 DI 10.1016/j.is.2005.05.005 PG 20 WC Computer Science, Information Systems SC Computer Science GA 218LC UT WOS:000250016000002 ER PT J AU Qasim, MM Moore, B Taylor, L Honea, P Gorb, L Leszczynski, J AF Qasim, Mohammad M. Moore, Brett Taylor, Lyssa Honea, Patricia Gorb, Leonid Leszczynski, Jerzy TI Structural characteristics and reactivity relationships of nitroaromatic and nitramine explosives - A review of our computational chemistry and spectroscopic research SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE nitroaromatic / nitramine explosives; structural / activity relationships; degradation mechanisms ID DEGRADATION REACTION-MECHANISMS; CATFISH ICTALURUS-PUNCTATUS; HIGHLY CONTAMINATED SOILS; ZERO-VALENT IRON; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; ALKALINE-HYDROLYSIS; MOLECULAR-STRUCTURE; AB-INITIO; UNIMOLECULAR DECOMPOSITION; TRINITROTOLUENE TNT AB Although much has been discovered, discussed and written as to problems of contamination by various military unique compounds, particularly by the nitrogen based energetics (NOCs), remaining problems dictate further evaluation of actual and potential risk to the environment by these energetics and their derivatives and metabolites through determination of their environmental impact-transport, fate and toxicity. This work comprises an effort to understand structural relationships and degradation mechanisms of current and emerging explosives, including nitroaromatic; cyclic and cage cyclic nitramine; and a nitrocubane. This review of our computational chemistry and spectroscopic research describes and compares competitive degradation mechanisms by free radical oxidative, reductive and alkali hydrolysis, relating them, when possible, to environmental risk. C1 [Qasim, Mohammad M.; Moore, Brett; Taylor, Lyssa; Gorb, Leonid; Leszczynski, Jerzy] USAE ERDC EL, Vicksburg, MS USA. [Honea, Patricia] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA. [Leszczynski, Jerzy] Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS USA. RP Qasim, MM (reprint author), USAE ERDC EL, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM qasimm@wes.army.mil NR 107 TC 17 Z9 17 U1 4 U2 21 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1422-0067 J9 INT J MOL SCI JI Int. J. Mol. Sci. PD DEC PY 2007 VL 8 IS 12 BP 1234 EP 1264 DI 10.3390/i8121234 PG 31 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary SC Biochemistry & Molecular Biology; Chemistry GA 256FD UT WOS:000252712200004 ER PT J AU Gilhooly, CH Das, SK Golden, JK McCrory, MA Dallal, GE Saltzman, E Kramer, FM Roberts, SB AF Gilhooly, C. H. Das, S. K. Golden, J. K. McCrory, M. A. Dallal, G. E. Saltzman, E. Kramer, F. M. Roberts, S. B. TI Food cravings and energy regulation: the characteristics of craved foods and their relationship with eating behaviors and weight change during 6 months of dietary energy restriction SO INTERNATIONAL JOURNAL OF OBESITY LA English DT Article DE food craving; weight loss; energy density; energy restriction ID HUMAN-BODY COMPOSITION; LOW-CALORIE DIET; HEALTHY WOMEN; ELDERLY ADULTS; YOUNG-WOMEN; APPETITE; RESTRAINT; HUNGER; REWARD; BRAIN AB Objective: To examine characteristics of craved foods in relation to dietary energy restriction ( ER) with high (HG) and low glycemic load (LG) diets. Design: Assessments of food cravings before and during a randomized controlled trial of HG and LG diets provided for 6 months. Subjects: Thirty-two healthy, overweight women aged 20-42 years. Measurements: Self-reported food cravings and dietary intake, body weight, weight history and measures of eating behaviors. Results: Foods craved at baseline were more than twice as high in energy density as the habitual diet (3.7 +/- 1.5 vs 1.7 +/- 0.3 kcal/g; P < 0.001), and on average were lower in protein (P < 0.001) and fiber (P < 0.001) and higher in fat (P=0.002). There were no statistically significant changes in nutritional characteristics of craved foods after 6 months of ER. There was a significant relationship between reported portion size of craved food consumed at baseline and lifetime high body mass index (r=0.49, P=0.005). Additionally, there was a significant association between susceptibility to hunger and craving frequency at baseline, and there were significant relationships between hunger score, craving frequency, strength and percentage of time that cravings are given in to after 6 months of ER. In multiple regression models, subjects who lost a greater percentage of weight craved higher energy-dense foods at month 6 of ER, but also reported giving in to food cravings less frequently (adjusted R-2 = 0.31, P=0.009). Conclusion: High energy density and fat content, and low protein and fiber contents were identifying characteristics of craved foods. The relationships between craving variables and hunger score suggest that the relative influence of hunger susceptibility on cravings may be important before and especially after ER. Portion size of craved foods and frequency of giving in to food cravings appear to be important areas for focus in lifestyle modification programs for long-term weight loss. C1 Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA USA. US FDA, Silver Spring, MD USA. Bastyr Univ, Sch Nutr & Exercise Sci, Kenmore, WA USA. US Army Natick Soldier Ctr, Ctr Dev & Engn, Natick, MA USA. RP Roberts, SB (reprint author), Tufts Univ, USDA, Human Nutr Res Ctr Aging, Energy Met Lab, Rm 1312, 711 Washington St, Boston, MA 02111 USA. EM susan.roberts@tufts.edu RI Biguzzi, Felipe/E-4724-2015 FU NIA NIH HHS [U01-AG20480] NR 54 TC 40 Z9 42 U1 1 U2 9 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0307-0565 J9 INT J OBESITY JI Int. J. Obes. PD DEC PY 2007 VL 31 IS 12 BP 1849 EP 1858 DI 10.1038/sj.ijo.0803672 PG 10 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 234OK UT WOS:000251173200010 PM 17593902 ER PT J AU Yuan, F Tsai, L Prakash, V Rajendran, AM Dandekar, DP AF Yuan, Fuping Tsai, Liren Prakash, Vikas Rajendran, A. M. Dandekar, Dattatraya P. TI Spall strength of glass fiber reinforced polymer composites SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES LA English DT Article DE layered heterogeneous material systems; spall strength; delamination strength; glass fiber reinforced polymer composite (GRP); plate impact experiments ID INTEGRAL ARMOR; EPOXY COMPOSITE; IMPACT; BEHAVIOR; INTERFEROMETER; ALUMINUM; WAVINESS AB In the present paper results of a series of plate impact experiments designed to study spall strength in glass-fiber reinforced polymer composites (GRP) are presented. Two GRP architectures are investigated-S2 glass woven roving in Cycom 4102 polyester resin matrix and a balanced 5-harness satin weave E-glass in a Ciba epoxy (LY564) matrix. The GRP specimens were shock loaded using an 82.5 mm bore single-stage gas-gun. A velocity interferometer was used to measure the particle velocity profile at the rear (free) surface of the target plate. The spall strength of the GRP was obtained as a function of the normal component of the impact stress and the applied shear-strain by subjecting the GRP specimens to normal shock compression and combined shock compression and shear loading, respectively. The spall strengths of the two GRP composites were observed to decrease with increasing levels of normal shock compression. Moreover, superposition of shear-strain on the normal shock compression was found to be highly detrimental to the spall strength, The E-glass reinforced GRP composite was found to have a much higher level of spall strength under both normal shock compression and combined compression and shear loading when compared to the S2-glass GRP composite. The maximum spall strength of the E-glass GRP composite was found to be 119.5 MPa, while the maximum spall strength for the S2 glass GRP composite was only 53.7 MPa. These relatively low spall strength levels of the S2-glass and the E-glass fiber reinforced composites have important implications to the design and development of GRP-based light-weight integral armor. (C) 2007 Elsevier Ltd. All rights reserved. C1 Case Western Reserve Univ, Dept Mech & Aerosp Engn, Cleveland, OH 44106 USA. Engn Sci Directorate, Army Res Off, Res Triangle Pk, NC 27709 USA. Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Prakash, V (reprint author), Case Western Reserve Univ, Dept Mech & Aerosp Engn, Cleveland, OH 44106 USA. EM fxy11@case.edu; lxt23@case.edu; vikas.prakash@case.edu; raj@arl.aro.army.mil; ddandek@arl.army.mil RI Rajendran, Arunachalam/A-1615-2010 NR 29 TC 13 Z9 14 U1 2 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0020-7683 J9 INT J SOLIDS STRUCT JI Int. J. Solids Struct. PD DEC 1 PY 2007 VL 44 IS 24 BP 7731 EP 7747 DI 10.1016/j.ijsoistr.2007.05.007 PG 17 WC Mechanics SC Mechanics GA 232DR UT WOS:000250999000002 ER PT J AU Montain, SJ Cheuvront, SN Lukaski, HC AF Montain, Scoft J. Cheuvront, Samuel N. Lukaski, Henry C. TI Sweat mineral-element responses during 7 h of exercise-heat stress SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE sodium; potassium; zinc; copper; magnesium; calcium ID WHOLE-BODY; LOSSES; CALCIUM; IRON; ACCLIMATIZATION; COLLECTION; HUMANS; PLASMA; MALES AB Context: Uncertainty exists regarding the effect of sustained sweating on sweat mineral-element composition. Purpose: To determine the effect of multiple hours of exercise-heat stress on sweat mineral concentrations. Methods: Seven heat-acclimated subjects (6 males, 1 female) completed 5 x 60 min of treadmill exercise (1.56 m/s, 2% grade) with 20 min rest between exercise periods in 2 weather conditions (27 degrees C, 40% relative humidity, 1 m/s and 35 degrees C, 30%, 1 m/s). Sweat was collected from a sweat-collection pouch attached to the upper back during exercise bouts 1, 3, and 5. Mineral elements were determined by using inductively coupled plasma-emission spectrography. Results: At 27 degrees C, sweat sodium (863 [563] mu g/mL; mean [SD]), potassium (222 [48] mu g/mL), calcium (16 [71] mu g/mL), magnesium (1265 [566] ng/mL), and copper (80 [56] ng/mL) remained similar to baseline over 7 h of exercise-heat stress, whereas sweat zinc declined 42-45% after the initial hour of exercise-heat stress (Ex1 = 655 [362], Ex3 = 382 [168], Ex5 = 355 [288] mu g/mL, P < 0.05). Similar outcomes were observed for sweat zinc at 35 degrees C when sweat rates were higher. Sweat rate had no effect on sweat trace-element composition. Conclusions: Sweat sodium, potassium, and calcium losses during multiple hours of sustained sweating can be predicted from initial sweat composition. Estimates of sweat zinc losses, however, will be overestimated if sweat zinc conservation is not accounted for in sweat zinc-loss estimates. C1 [Montain, Scoft J.; Cheuvront, Samuel N.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Lukaski, Henry C.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA. RP Montain, SJ (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. NR 24 TC 35 Z9 37 U1 4 U2 12 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD DEC PY 2007 VL 17 IS 6 BP 574 EP 582 PG 9 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 240AP UT WOS:000251559700005 PM 18156662 ER PT J AU Cooperberg, MR Duh, QY Stackhouse, GB Stoller, ML AF Cooperberg, Matthew R. Duh, Quan-Yang Stackhouse, G. Bennett Stoller, Marshall L. TI Oral calcium supplementation associated with decreased likelihood of nephrolithiasis prior to surgery for hyperparathyroidism SO INTERNATIONAL JOURNAL OF UROLOGY LA English DT Article DE calcium; hypercalcemia; hyperparathyroidism; nephrolithiasis ID KIDNEY-STONES; RISK AB We aimed to assess the impact of oral calcium supplementation (OCS) on the prevalence of nephrolithiasis among a cohort of patients undergoing surgery for primary hyperparathyroidism (PHPT). There were 339 patients undergoing surgery for PHPT with detailed past medical history data that were analyzed. 73 patients (22%) had a history of nephrolithiasis prior to parathyroid surgery. Nephrolithiasis was more common among men than women (40% vs 15%, P < 0.001), despite the predominance of women (73% of patients) with hyperparathyroidism. 83 patients (25%) used OCS. OCS was associated with a lower prevalence of nephrolithiasis (9.6% vs 25.4% without OCS, P = 0.002). This protective effect included both men and women (rates of nephrolithiasis with and without supplements: men 19% vs 46%, P = 0.027; women 7% vs 17%, P = 0.04). The mechanism for the apparent protective effect of OCS on rates of nephrolithiasis is unclear, and further research is required to elucidate the variable penetrance of nephrolithiasis among PHPT patients. C1 Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA. Univ Calif San Francisco, Dept Surg, San Francisco, CA 94143 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Stoller, ML (reprint author), Univ Calif San Francisco, Dept Urol, Box 0738,400 Parnassus A-633, San Francisco, CA 94143 USA. EM mstoller@urology.ucsf.edu RI Cooperberg, Matthew/B-3867-2008 NR 10 TC 3 Z9 3 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0919-8172 J9 INT J UROL JI Int. J. Urol. PD DEC PY 2007 VL 14 IS 12 BP 1113 EP 1115 DI 10.1111/j.1442-2042.2007.01904.x PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 234VF UT WOS:000251191400020 PM 18036056 ER PT J AU Dennison, SK Jacobs, SA Wilson, JW Seeger, J Cescon, TP Raymond, JM Geyer, CE Wolmark, N Swain, SM AF Dennison, Sheri K. Jacobs, Samuel A. Wilson, John W. Seeger, Janell Cescon, Terrence P. Raymond, Jane M. Geyer, Charles E. Wolmark, Norman Swain, Sandra M. TI A phase II clinical trial of ZD1839 (Iressa (TM)) in combination with docetaxel as first-line treatment in patients with advanced breast cancer SO INVESTIGATIONAL NEW DRUGS LA English DT Article DE chemotherapy; clinical trials; adult medical oncology; advanced breast cancer ID GROWTH-FACTOR-RECEPTOR; TYROSINE KINASE INHIBITOR; CELL LUNG-CANCER; PROGNOSTIC VALUE; MULTICENTER TRIAL; ONCOLOGY-GROUP; SOLID TUMORS; FOLLOW-UP; GEFITINIB; PACLITAXEL AB This was a phase II multi-institutional trial to determine the efficacy and tolerability of gefitinib (Iressa (TM)) and docetaxel as first-line treatment in patients with metastatic breast cancer. All patients had histologically confirmed breast cancer with metastatic disease. They were permitted to have received adjuvant chemotherapy, but no prior docetaxel or prior chemotherapy for metastatic disease. Patients received gefitinib 250 mg once daily and docetaxel 75 mg/m(2) stop every 3 weeks, until tumor progression, toxicity or other reasons for discontinuation. Thirty-three patients were enrolled and received a median of 5 cycles of treatment. The clinical benefit rate was 51.5% (95% CI: 33.5-69.2%). There were 1 confirmed complete response and 12 confirmed partial responses, and the overall objective response rate was 39.4% (95% CI: 22.9-57.9%). Four patients had stable disease for +/- 24 weeks. The median duration of clinical benefit was 10.9 months (95% CI: 6.0-17.6 months). The most common reason for study discontinuation was disease progression (16 patients), followed by toxicity (ten patients). Toxicities were mainly attributable to docetaxel, including >= 3 neutropenia in 43% of patients. The combination of gefitinib and docetaxel is an active regimen in patients with previously untreated metastatic breast cancer, with a clinical benefit rate and toxicity profile in the range of that reported for docetaxel alone. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NSABP, Pittsburgh, PA USA. FRP, Pittsburgh, PA USA. Univ Pittsburgh, Ctr Med, Canc Ctr, Pittsburgh, PA USA. RP Dennison, SK (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM dennisonsk@mail.nih.gov OI Swain, Sandra/0000-0002-1320-3830 FU Intramural NIH HHS NR 40 TC 14 Z9 15 U1 1 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-6997 J9 INVEST NEW DRUG JI Invest. New Drugs PD DEC PY 2007 VL 25 IS 6 BP 545 EP 551 DI 10.1007/s10637-007-9055-6 PG 7 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA 215KS UT WOS:000249807800005 PM 17563856 ER PT J AU Hsu, LL Nevin, RL Tobler, SK Rubertone, MV AF Hsu, Lucy L. Nevin, Remington L. Tobler, Steven K. Rubertone, Mark V. TI Trends in overweight and obesity among 18-year-old applicants to the united states military, 1993-2006 SO JOURNAL OF ADOLESCENT HEALTH LA English DT Article DE obesity; overweight; military personnel; body mass index ID ADULTS AB We examined trends in overweight and obesity among 756,269 18-year-old civilian applicants to the United States military from 1993-2006. The prevalence of overweight increased from 22.8% in 1993 to 27.1 % in 2006, and obesity increased from 2.8% to 6.8%.We conclude the U.S. military is recruiting from an increasingly overweight population. (c) 2007 Society for Adolescent Medicine. All rights reserved. C1 USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD 20910 USA. RP Nevin, RL (reprint author), USA, Ctr Hlth Promot & Prevent Med, 2900 Linden Lane,Suite 200, Silver Spring, MD 20910 USA. EM remington.nevin@us.army.mil OI Nevin, Remington/0000-0002-0534-1889 NR 10 TC 30 Z9 31 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD DEC PY 2007 VL 41 IS 6 BP 610 EP 612 DI 10.1016/j.jadohealth.2007.07.012 PG 3 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA 237MI UT WOS:000251377800015 PM 18023791 ER PT J AU Rabinowitz, YG Mausbach, BT Thompson, LW Gallagher-Thompson, D AF Rabinowitz, Yaron G. Mausbach, Brent T. Thompson, Larry W. Gallagher-Thompson, Dolores TI The relationship self-efficacy and between cumulative health risk associated with health behavior patterns in female caregivers of elderly relatives with Alzheimer's dementia SO JOURNAL OF AGING AND HEALTH LA English DT Article DE self-efficacy; predictors of health; health behaviors ID FAMILY CAREGIVERS; PHYSICAL HEALTH; SPOUSE CAREGIVERS; OLDER-ADULTS; DEPRESSION; STRESS; WOMEN; REACH; INTERVENTION; MEDIATORS AB Objective: To promote caregiver well-being and to help caregivers persevere in their invaluable roles, personal resources that predict increased self-care and reduced health risk behaviors need to be identified. Method: This study examined relationships between self-efficacy beliefs in three distinct domains of caregiving and cumulative health risk associated with health behavior patterns. Results: Higher levels of self-efficacy for Obtaining Respite and self-efficacy for Controlling Upsetting Thoughts were found to be related to reduced health risk. Discussion: These findings suggest that caregivers who believe that they can remove themselves from the stresses of caregiving and who can manage the distorted cognitions often associated with caregiving may experience tangible benefits in health behaviors and, ultimately, improved physical health. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Univ Calif San Diego, San Diego, CA 92103 USA. Stanford Univ, Sch Med, Menlo Pk, CA USA. Stanford Univ, Sch Med, Palo Alto, CA 94304 USA. RP Rabinowitz, YG (reprint author), 2720 Franciscan Dr, Fayetteville, NC 28306 USA. FU NIA NIH HHS [UO1-AG13289]; PHS HHS [23989] NR 53 TC 33 Z9 34 U1 1 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0898-2643 J9 J AGING HEALTH JI J. Aging Health PD DEC PY 2007 VL 19 IS 6 BP 946 EP 964 DI 10.1177/0898264307308559 PG 19 WC Gerontology; Health Policy & Services SC Geriatrics & Gerontology; Health Care Sciences & Services GA 233BL UT WOS:000251065300005 PM 18165290 ER PT J AU Nation, RC AF Nation, R. Craig TI The battle over the Soviet Jews: Washington-Moscow-Jerusalem,1953-1989 SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Nation, R. Craig] USA, War Coll, Carlisle, PA USA. RP Nation, RC (reprint author), USA, War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD DEC PY 2007 VL 94 IS 3 BP 991 EP 992 PG 2 WC History SC History GA 289VD UT WOS:000255081100121 ER PT J AU Klipp, C AF Klipp, Cheryl TI Wind direction dependence of atmospheric boundary layer turbulence parameters in the urban roughness sublayer SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID REYNOLDS STRESS; STATISTICS; SIMULATION; SURFACE; AREAS; MODEL; WALL AB A variety of atmospheric boundary layer parameters are examined as a function of wind direction in both urban and suburban settings in Oklahoma City, Oklahoma, derived from measurements during the Joint Urban 2003 field campaign. Heterogeneous surface characteristics result in significant differences in upwind fetch and, therefore, statistically significant differences in measured values, even for small changes in wind direction. Taller upwind obstructions yield larger measured values of drag coefficient and turbulence intensity than do shorter upwind obstructions regardless of whether the obstruction is a building or a tree. The fraction of turbulent kinetic energy going into streamwise, cross-stream, and vertical variances differs depending on the upwind fetch, and reduced cross-stream values may indicate locations of persistent wind stream convergence. In addition, a quadrant analysis of burst/sweep behavior near the surface is examined as a function of wind direction in urban and suburban environments. C1 US Army Res Lab, Adelphi, MD 20783 USA. RP Klipp, C (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM cklipp@arl.army.mil NR 22 TC 6 Z9 7 U1 2 U2 6 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD DEC PY 2007 VL 46 IS 12 BP 2086 EP 2097 DI 10.1175/2006JAMC1298.1 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 252FS UT WOS:000252433000006 ER PT J AU Wang, Y Klipp, CL Garvey, DM Ligon, DA Williamson, CC Chang, SS Newsom, RK Calhoun, R AF Wang, Yansen Klipp, Cheryl L. Garvey, Dennis M. Ligon, David A. Williamson, Chatt C. Chang, Sam S. Newsom, Rob K. Calhoun, Ronald TI Nocturnal low-level-jet-dominated atmospheric boundary layer observed by a Doppler lidar over Oklahoma City during JU2003 SO JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY LA English DT Article ID TURBULENCE STATISTICS; SURFACE EXCHANGE; MESOSCALE MODEL; URBAN SURFACE; PARAMETERIZATION; CASES-99; TERRAIN; HEAT; MASS AB Boundary layer wind data observed by a Doppler lidar and sonic anemometers during the mornings of three intensive observational periods (IOP2, IOP3, and IOP7) of the Joint Urban 2003 ( JU2003) field experiment are analyzed to extract the mean and turbulent characteristics of airflow over Oklahoma City, Oklahoma. A strong nocturnal low-level jet ( LLJ) dominated the flow in the boundary layer over the measurement domain from midnight to the morning hours. Lidar scans through the LLJ taken after sunrise indicate that the LLJ elevation shows a gradual increase of 25-100 m over the urban area relative to that over the upstream suburban area. The mean wind speed beneath the jet over the urban area is about 10%-15% slower than that over the suburban area. Sonic anemometer observations combined with Doppler lidar observations in the urban and suburban areas are also analyzed to investigate the boundary layer turbulence production in the LLJ-dominated atmospheric boundary layer. The turbulence kinetic energy was higher over the urban domain mainly because of the shear production of building surfaces and building wakes. Direct transport of turbulent momentum flux from the LLJ to the urban street level was very small because of the relatively high elevation of the jet. However, since the LLJ dominated the mean wind in the boundary layer, the turbulence kinetic energy in the urban domain is correlated directly with the LLJ maximum speed and inversely with its height. The results indicate that the jet Richardson number is a reasonably good indicator for turbulent kinetic energy over the urban domain in the LLJ-dominated atmospheric boundary layer. C1 [Wang, Yansen; Klipp, Cheryl L.; Garvey, Dennis M.; Ligon, David A.; Williamson, Chatt C.; Chang, Sam S.] US Army Res Lab, Attn AMSRD ARL CI EM, Adelphi, MD 20783 USA. [Newsom, Rob K.] Pacific NW Natl Lab, Atomspher Sci Global Change Div, Richland, WA 99352 USA. [Calhoun, Ronald] Arizona State Univ, Environm Fluid Dyam Program, Tempe, AZ USA. RP Wang, Y (reprint author), US Army Res Lab, Attn AMSRD ARL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ywang@arl.army.mil NR 46 TC 18 Z9 19 U1 0 U2 11 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1558-8424 J9 J APPL METEOROL CLIM JI J. Appl. Meteorol. Climatol. PD DEC PY 2007 VL 46 IS 12 BP 2098 EP 2109 DI 10.1175/2006JAMC1283.1 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 252FS UT WOS:000252433000007 ER PT J AU Chakraborti, D Trichy, G Narayan, J Prater, JT Kumar, D AF Chakraborti, D. Trichy, G. Narayan, J. Prater, J. T. Kumar, D. TI Effect of Al doping on the magnetic and electrical properties of Zn(Cu)O based diluted magnetic semiconductors SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CO-DOPED ZNO; THIN-FILMS; FERROMAGNETIC PROPERTIES; OXIDES AB The effect of Al doping on the magnetic properties of Zn(Cu)O based dilute magnetic semiconducting thin films has been systematically investigated. Epitaxial thin films have been deposited onto sapphire c-plane single crystals using pulsed laser deposition technique. X-ray diffraction and high resolution transmission electron microscopy studies show that the Zn(Cu,Al)O films are epitaxially grown onto (0001) sapphire substrates with a 30 degrees/90 degrees rotation in the basal plane. The large lattice misfit of the order of 16% is accommodated by matching integral multiples of lattice and substrate planes. In these large mismatch systems, the resulting films are fully relaxed following deposition of the first complete monolayer of ZnO (consistent with a critical thickness that is less than one monolayer). Magnetic hysteresis measurements indicate that the pure Zn(Cu)O thin films are ferromagnetic at room temperature. Doping with up to 5% Al (n type) does not significantly affect the ferromagnetism even though it results in an increase in carrier densities of more than 3 orders of magnitude, rising from 1x10(17) to 1.5x10(20) cm(-3). However, for Al additions above 5%, a drop in net magnetization is observed. Annealing the films in an oxygen atmosphere at 600 degrees C also resulted in a dramatic drop in magnetic moment of the samples. These results strongly suggest that carrier induced exchange is not directly responsible for the magnetic properties of these materials. Rather, a defect mediated exchange mechanism needs to be invoked for this system. (c) 2007 American Institute of Physics. C1 [Chakraborti, D.; Trichy, G.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] Army Res Off, Mat Sci Div, Res Triangle Pk, NC 27709 USA. [Kumar, D.] N Carolina Agr & Tech State Univ, Dept Mech & Chem Engn, Greensboro, NC 27411 USA. RP Chakraborti, D (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. EM dchakra@ncsu.edu RI Narayan, Jagdish/D-1874-2009 NR 36 TC 15 Z9 17 U1 0 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 1 PY 2007 VL 102 IS 11 AR 113908 DI 10.1063/1.2817824 PG 7 WC Physics, Applied SC Physics GA 241TN UT WOS:000251678800077 ER PT J AU Castellani, JW O'Brien, C Tikuisis, P Sils, IV Xu, XJ AF Castellani, John W. O'Brien, Catherine Tikuisis, Peter Sils, Ingrid V. Xu, Xiaojiang TI Evaluation of two cold thermoregulatory models for prediction of core temperature during exercise in cold water SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE heat content; hypothermia; shivering ID HUMAN THERMAL RESPONSES; BODY-TEMPERATURE; SURVIVAL-TIME; HEAT-BALANCE; IMMERSION; FAT; MAINTENANCE; INTENSITY; EXPOSURE; WALKING AB Evaluation of two cold thermoregulatory models for prediction of core temperature during exercise in cold water. J Appl Physiol 103: 2034-2041, 2007. First published September 20, 2007; doi: 10.1152/japplphysiol.00499.2007.-Cold thermoregulatory models (CTM) have primarily been developed to predict core temperature (T-core) responses during sedentary immersion. Few studies have examined their efficacy to predict Tcore during exercise cold exposure. The purpose of this study was to compare observed Tcore responses during exercise in cold water with the predicted Tcore from a three-cylinder (3-CTM) and a six-cylinder (6-CTM) model, adjusted to include heat production from exercise. A matrix of two metabolic rates (0.44 and 0.88 m/s walking), two water temperatures (10 and 15 C), and two immersion depths (chest and waist) were used to elicit different rates of Tcore changes. Root mean square deviation (RMSD) and nonparametric Bland-Altman tests were used to test for acceptable model predictions. Using the RMSD criterion, the 3-CTM did not fit the observed data in any trial, whereas the 6-CTM fit the data (RMSD less than standard deviation) in four of eight trials. In general, the 3-CTM predicted a rapid decline in core temperature followed by a plateau. For the 6-CTM, the predicted Tcore appeared relatively tight during the early part of immersion, but was much lower during the latter portions of immersion, accounting for the nonagreement between RMSD and SD values. The 6-CTM was rerun with no adjustment for exercise metabolism, and core temperature and heat loss predictions were tighter. In summary, this study demonstrated that both thermoregulatory models designed for sedentary cold exposure, currently, cannot be extended for use during partial immersion exercise in cold water. Algorithms need to be developed to better predict heat loss during exercise in cold water. C1 [Castellani, John W.; O'Brien, Catherine; Sils, Ingrid V.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Xu, Xiaojiang] USA, Environm Med Res Inst, Biophys & Biomodeling Div, Natick, MA 01760 USA. [Tikuisis, Peter] Def Res & Dev Canada Toronto, N York, ON, Canada. RP Castellani, JW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, 42 Kansas St, Natick, MA 01760 USA. EM john.castellani@us.army.mil NR 34 TC 11 Z9 11 U1 2 U2 6 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 2007 VL 103 IS 6 BP 2034 EP 2041 DI 10.1152/japplphysiol.00499.2007 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 239TJ UT WOS:000251540300017 PM 17885026 ER PT J AU Blazer, VS Iwanowicz, LR Iwanowicz, DD Smith, DR Young, JA Hedrick, JD Foster, SW Reeser, SJ AF Blazer, V. S. Iwanowicz, L. R. Iwanowicz, D. D. Smith, D. R. Young, J. A. Hedrick, J. D. Foster, S. W. Reeser, S. J. TI Intersex (testicular oocytes) in smallmouth bass from the Potomac River and selected nearby drainages SO JOURNAL OF AQUATIC ANIMAL HEALTH LA English DT Article ID MEDAKA ORYZIAS-LATIPES; ROACH RUTILUS-RUTILUS; FLOUNDER PLATICHTHYS-FLESUS; ZEBRAFISH DANIO-RERIO; GONADAL DEVELOPMENT; TESTIS-OVA; ENDOCRINE DISRUPTION; SEXUAL DISRUPTION; ENVIRONMENTAL CONTAMINANTS; GOBIO-GOBIO AB Intersex, or the presence of characteristics of both sexes, in fishes that are normally gonochoristic has been used as an indicator of exposure to estrogenic compounds. In 2003, during health assessments conducted in response to kills and a high prevalence of skin lesions observed in smallmouth bass Micropterus dolomieu in the South Branch of the Potomac River, the presence of immature oocytes within testes was noted. To evaluate this condition, a severity index (0-4) was developed based on the distribution of oocytes within the testes. Using gonad samples collected from 2003 to 2005, the number of histologic sections needed to accurately detect the condition in mature smallmouth bass was statistically evaluated. The reliability of detection depended on the severity index and the number of sections examined. Examining five transverse sections taken along the length of the gonad resulted in a greater than 90% probability of detecting testicular oocytes when the severity index exceeded 0.5. Using the severity index we compared smallmouth bass collected at selected sites within the South Branch during three seasons in 2004. Seasonal differences in severity and prevalence were observed. The highest prevalence and severity were consistently noted during the prespawn-spawning season, when compared with the postspawn season. In 2005, smallmouth bass were collected at selected out-of-basin sites in West Virginia where fish kills and external skin lesions have not been reported, as well as at sites in the Shenandoah River, Virginia (part of the Potomac drainage), where kills and lesions occurred in 2004-2005. The prevalence of testicular oocytes is discussed in terms of human population and agricultural intensity. C1 [Blazer, V. S.; Iwanowicz, L. R.; Iwanowicz, D. D.] US Geol Survey, Natl Fish Hlth Res Lab, Kearneysville, WV 25430 USA. [Smith, D. R.; Young, J. A.] US Geol Survey, Aquat Ecol Branch, Kearneysville, WV 25430 USA. [Hedrick, J. D.] W Virginia Div Nat Resources, Romney, WV 26757 USA. [Foster, S. W.] USA, Corps Engn, Apple Grove, WV 25502 USA. [Reeser, S. J.] Virginia Dept Game & Inland Fisheries, Verona, VA 24482 USA. RP Blazer, VS (reprint author), US Geol Survey, Natl Fish Hlth Res Lab, 11649 Leetown Rd, Kearneysville, WV 25430 USA. EM vblazer@usgs.gov OI Iwanowicz, Luke/0000-0002-1197-6178 NR 59 TC 68 Z9 68 U1 3 U2 24 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0899-7659 J9 J AQUAT ANIM HEALTH JI J. Aquat. Anim. Health PD DEC PY 2007 VL 19 IS 4 BP 242 EP 253 DI 10.1577/H07-031.1 PG 12 WC Fisheries; Veterinary Sciences SC Fisheries; Veterinary Sciences GA 261RM UT WOS:000253097700005 PM 18333481 ER PT J AU La Scala, JJ Jeyarajasingam, A Logan, MS Winston, C Myers, P Sands, JM Palmese, GR AF La Scala, John J. Jeyarajasingam, Amutha Logan, Matthew S. Winston, Cherise Myers, Philip Sands, James M. Palmese, Giuseppe R. TI Fatty acid-based vinyl ester composites with low hazardous air pollutant contents SO JOURNAL OF BIOBASED MATERIALS AND BIOENERGY LA English DT Article DE fatty acid monomers; styrene replacements/alternatives; vinyl esters; composites ID CURE KINETICS; RESINS; MONOMERS AB Fatty acid monomers have recently been shown to be a potential alternative for styrene monomer in vinyl ester and unsaturated polyester resins. These monomers are non-volatile, and therefore reduce the hazardous air pollutant (HAP) and volatile organic compound (VOC) content of these resins. Vinyl ester formulations containing various amounts of vinyl ester monomer, styrene, and fatty acid monomer were prepared. Two fatty acid monomers were used to determine the effect of fatty acid type on resin, polymer, and composite performance: methacrylated lauric acid (MLau) and methacrylated hexanoic acid (MHex). Both monomers contain one vinyl group capable of polymerizing with styrene and vinyl ester, but MLau monomer is six carbon atoms longer than MHex. The viscosity of the fatty acid formulations were within the range of commercial vinyl ester resins, but MHex resins had slightly lower viscosities than the MLau resins due to the shorter chain length of MHex. Similarly, the glass transition temperatures (T-g) of MHex polymers were slightly higher than that of MLau polymers. Regardless, some formulations were established that had similar T-g relative to commercial vinyl ester resins. Neat flexural properties of the resins decreased significantly for the fatty acid-based resins as the styrene content was reduced below 20 wt%. This reduction was more significant for MLau-based resins because of their lower T(g)s. On the other hand, flexural and inter-laminar properties of fatty acid-based resins were similar to that of commercial resins for all resin formulations tested. This indicates that improved fiber-matrix adhesion could be occurring in fatty acid-based composites relative to composites made using commercial resins. C1 [La Scala, John J.; Winston, Cherise; Myers, Philip; Sands, James M.] AMSRD ARL WM, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Jeyarajasingam, Amutha; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Logan, Matthew S.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. RP La Scala, JJ (reprint author), AMSRD ARL WM, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 19 TC 4 Z9 4 U1 3 U2 12 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1556-6560 J9 J BIOBASED MATER BIO JI J. Biobased Mater. Bioenergy PD DEC PY 2007 VL 1 IS 3 BP 409 EP 416 DI 10.1166/jbmb.2007.017 PG 8 WC Chemistry, Applied; Energy & Fuels; Materials Science, Biomaterials SC Chemistry; Energy & Fuels; Materials Science GA 265DT UT WOS:000253340000014 ER PT J AU DiFazio, MP Braun, L Freedman, S Hickey, P AF DiFazio, Marc P. Braun, Loranee Freedman, Scott Hickey, Patrick TI Rotavirus-induced seizures in childhood SO JOURNAL OF CHILD NEUROLOGY LA English DT Article DE rotavirus; seizure; encephalopathy; virus; epilepsy ID NERVOUS-SYSTEM INVOLVEMENT; CEREBROSPINAL-FLUID; MILD GASTROENTERITIS; BENIGN CONVULSIONS; INFECTION; ENCEPHALOPATHY; DISEASE AB Rotavirus infection is a frequent cause of gastroenteritis in children and accounts for significant morbidity and mortality, especially in the developing world. Less well recognized is the association of rotavirus-induced central nervous system dysfunction, which has been associated with seizure, encephalopathy, and death. Symptoms may vary widely, however, and children can experience short afebrile convulsions as the only manifestation of rotavirus encephalopathy, We report 4 further cases of rotavirus-induced seizures with mild neurologic manifestations. The condition is reviewed and practical management strategies are suggested. C1 [DiFazio, Marc P.; Braun, Loranee; Hickey, Patrick] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Freedman, Scott] Shady Grove Hosp Children, Rockville, MD USA. [Braun, Loranee; Hickey, Patrick] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP DiFazio, MP (reprint author), 9715 Med Ctr Dr,Suite 233, Rockville, MD 20850 USA. EM mddifazio@aol.com NR 27 TC 35 Z9 36 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0883-0738 J9 J CHILD NEUROL JI J. Child Neurol. PD DEC PY 2007 VL 22 IS 12 BP 1367 EP 1370 DI 10.1177/0883073807307083 PG 4 WC Clinical Neurology; Pediatrics SC Neurosciences & Neurology; Pediatrics GA 240MJ UT WOS:000251591400007 PM 18174553 ER PT J AU Salem, TE Bayne, SB Porschet, D AF Salem, Thomas E. Bayne, Stephen B. Porschet, Don TI An experimental approach for thermal characterization of water-cooled heat sinks using Fourier analysis techniques SO JOURNAL OF ELECTRONIC PACKAGING LA English DT Article; Proceedings Paper CT 21st Annual IEEE Semiconductor Thermal Measurement and Management Symposium CY MAR 15-17, 2005 CL San Jose, CA SP IEEE, CPMT, Natl Inst Stand & Technol ID DESIGN AB As power electronic applications continue to switch higher levels of voltage and current in smaller-sized component packages, the resulting increase in power density requires efficient thermal management. This paper compares the thermal performance for operating a metal-oxide-semiconductor field-effect transistor on a water-cooled pole-arrayed heat sink versus a novel water-cooled microchannel heat sink. Details are presented on an innovative technique using Fourier analysis techniques for determining the thermal capacitance modeling parameter for the heat sinks from experimental data. C1 [Salem, Thomas E.] USN Acad, Dept Elect Engn, Annapolis, MD 21402 USA. [Bayne, Stephen B.; Porschet, Don] USA, Res Lab, Adelphi, MD 20783 USA. RP Salem, TE (reprint author), USN Acad, Dept Elect Engn, 105 Maryland Ave, Annapolis, MD 21402 USA. EM salem@usna.edu NR 12 TC 0 Z9 0 U1 1 U2 5 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1043-7398 J9 J ELECTRON PACKAGING JI J. Electron. Packag. PD DEC PY 2007 VL 129 IS 4 BP 512 EP 517 DI 10.1115/1.2814056 PG 6 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA 247VJ UT WOS:000252110400018 ER PT J AU Manous, JD Gantzer, CJ Stefan, HG AF Manous, Joe D., Jr. Gantzer, Charles J. Stefan, Heinz G. TI Spatial variation of sediment sulfate reduction rates in a saline lake SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID ESTUARINE SEDIMENTS; MARINE-SEDIMENTS; ORGANIC-MATTER; NORTH-DAKOTA; WATER-COLUMN; DEVILS LAKE; MODEL AB Devils Lake in North Dakota is a terminal, multibasin, saline lake with an overall surface area that is currently approximately 44,520 ha (110,000 acres). Lake elevation has increased by more than 7 m within 10 years, and vast areas of prairie and cropland have been flooded. The lake is rich in sulfate, and water column sulfate concentrations are relatively uniform within each of the five major basins, but increase from 3.1 mM (300 mg/L) in West Bay to 31 mM (3,000 mg/L) in East Devils Lake. Sediment cores were collected from three of the basins at different water depths, and used in laboratory studies to evaluate the spatial distribution of sulfate-reducing bacteria (SRB) activity in the lake sediments. The high sulfate concentrations within the experimental sediment cores suggest that the activity of SRB is limited by the availability of suitable electron donors rather than by the availability of sulfate and that SRB activity can 11 to 88 mmol SO42- defined by a zero-order volumetric rate constant (K-0). Experimentally determined K-0 values ranged from 4 m(-3) day(-1). The water depths from which sediment cores were collected in Devils Lake are related to the elapsed time since inundation by the rising lake level. It was found that time since inundation influences the observed K-0 value. Mean K-0 values for cores from an average depth of 4.8 m (submergence time of about 5 years), and 9.4 m (submergence time of about 28 years) were 62 and 17 mmol SO42- m(-3) day(-1), respectively. The significant difference (two-tailed t-test, p<0.05) suggests that SRB activities in the Devils Lake sediments change with submergence times. A uniform sulfate reduction rate applied to all Devils Lake sediments is therefore only a crude approximation of reality. C1 US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. Barr Engn Co, Minneapolis, MN 55435 USA. Univ Minnesota, Dept Civil Engn, St Anthony Falls Lab, Minneapolis, MN 55414 USA. RP Manous, JD (reprint author), US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. NR 34 TC 3 Z9 4 U1 0 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD DEC PY 2007 VL 133 IS 12 BP 1106 EP 1116 DI 10.1061/(ASCE)0733-9372(2007)133:12(1106) PG 11 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 233DA UT WOS:000251069400005 ER PT J AU Wu, X Alshawabkeh, AN Gent, DB Larson, SL Davis, JL AF Wu, Xingzhi Alshawabkeh, Akrarn N. Gent, David B. Larson, Steven L. Davis, Jeffery L. TI Lactate transport in soil by DC fields SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article ID ENHANCED ELECTROKINETIC REMEDIATION; IN-SITU BIOREMEDIATION; REDUCTIVE DECHLORINATION; CONTAMINATED SOIL; TRICHLOROETHYLENE; TETRACHLOROETHENE; REMOVAL; KAOLINITE; INJECTION; HYDROGEN AB Electrokinetic injection of lactate, a negatively charged biodegradable organic, in homogeneous soils is evaluated. Net lactate migration rate on the order of 5 cm(2)/V day is measured in sand from cathode towards the anode. The ionic injection in sand was dependent on current density; however, the increase in electric current did not result in an equivalent increase in lactate transport due to development of an appreciable electroosmotic (EO) flow from the anode to the cathode. While high EO flow (k(e) on the order 10(-6) to 10(-5) cm(2)/V s) occurred in clay samples, ion migration from cathode to anode is the dominant transport process under relatively high current density (5.3 A/m(2) in this study) and can be used as an effective transport mechanism for negatively charged additives. An effective lactate reactive transport rate of more than 3 cm/d (under l V/cm) can be achieved in clays, which is at least two orders of magnitude greater than hydraulic injection under unit hydraulic gradient. Even though lactate concentrations in the clay were below 10% of the boundary value due to biological transformation, these concentrations (few 100 s mg/L) are high enough to maintain microbial activities capable of degrading organic contaminants. At the same time, control experiments showed that, while lactate adsorption was negligible, hydraulic injection under a unit gradient was ineffective because of the low hydraulic conductivity of clay and the biodegradation of lactate. C1 Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. USA, Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Alshawabkeh, AN (reprint author), Northeastern Univ, Dept Civil & Environm Engn, 400 Snell Engn,360 Huntington Ave, Boston, MA 02115 USA. EM aalsha@neu.edu NR 38 TC 11 Z9 11 U1 2 U2 11 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD DEC PY 2007 VL 133 IS 12 BP 1587 EP 1596 DI 10.1061/(ASCE)1090-0241(2007)133:12(1587) PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 233DC UT WOS:000251069600011 ER PT J AU Song, DJ Wohlrab, KP Ingari, JV AF Song, Daniel J. Wohlrab, Kurt P. Ingari, Jack V. TI Anterior ulnohumeral compression plate arthrodesis for revision complex elbow injury: A case report SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME LA English DT Article DE anterior compression plate; elbow arthrodesis; elbow fusion; gunshot wound; war injury ID WAR INJURIES; FUSION AB Elbow arthrodesis can be used for complex elbow injuries that are complicated or fail other conventional treatment methods. We present a case report of an anterior ulnohumeral compressive plate elbow arthrodesis for a patient with a complex elbow injury from a gunshot wound that failed initial open reduction and internal fixation and posterior ulnohumeral arthrodesis secondary to numerous complications. C1 [Song, Daniel J.; Wohlrab, Kurt P.; Ingari, Jack V.] William Beaumont Army Med Ctr, GME, El Paso, TX 79920 USA. [Song, Daniel J.; Wohlrab, Kurt P.; Ingari, Jack V.] Tripler Army Med Ctr, Dept Orthoped Surg, Honolulu, HI 96859 USA. [Song, Daniel J.; Wohlrab, Kurt P.; Ingari, Jack V.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Song, Daniel J.; Wohlrab, Kurt P.; Ingari, Jack V.] Hand Ctr San Antonio, San Antonio, TX USA. RP Song, DJ (reprint author), William Beaumont Army Med Ctr, GME, 5005 N Piedras St, El Paso, TX 79920 USA. EM song_daniel@hotmail.com NR 9 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0363-5023 J9 J HAND SURG-AM JI J. Hand Surg.-Am. Vol. PD DEC PY 2007 VL 32A IS 10 BP 1583 EP 1586 DI 10.1016/j.jhsa.2007.07.017 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 245OR UT WOS:000251945400015 PM 18070648 ER PT J AU Brundage, JF Shanks, GD AF Brundage, John F. Shanks, G. Dennis TI What really happened during the 1918 influenza pandemic? The importance of bacterial secondary infections SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID PREPAREDNESS; PNEUMONIA; VIRUS; INSIGHTS C1 USA, Ctr Hlth Promot & Prevent Med, Army Med Surveillnace Activ, Silver Spring, MD USA. Australian Army Malaria Inst, Enoggera, Qld, Australia. RP Brundage, JF (reprint author), USA, Ctr Hlth Promot & Prevent Med, Army Med Surveillnace Activ, Silver Spring, MD USA. NR 17 TC 22 Z9 22 U1 1 U2 8 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2007 VL 196 IS 11 BP 1717 EP 1718 DI 10.1086/522355 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 231RE UT WOS:000250965900021 PM 18008258 ER PT J AU Fountzoulas, CG Gazonas, GA Cheeseman, BA AF Fountzoulas, Costas G. Gazonas, George A. Cheeseman, Bryan A. TI Computational modeling of tungsten carbide sphere impact and penetration into high-strength-low-alloy (HSLA)-100 steel targets SO JOURNAL OF MECHANICS OF MATERIALS AND STRUCTURES LA English DT Article DE computational modeling; Lagrange; smoothed particle hydrodynamics (SPH); meshless particles; AUTODYN; tungsten carbide; HSLA-100 steel; impact ID FRAGMENTATION PROPERTIES; HSLA-100 STEEL; FAILURE; METALS AB The current investigation tested the existing material models of tungsten carbide and HSLA-100 steel by comparing available published experimental data, such as the depth and diameter of the impact crater, against the corresponding simulated results. Lagrange and smoothed particle hydrodynamics (SPH) simulations were carried out using an axisymmetric model of the tungsten carbide (WC) projectile and the HSLA-100 target. The Lagrange simulation predicted the crater diameter accurately. The SPH simulation efforts predicted the crater diameter with acceptable accuracy (within 15%) for impact velocities ranging from 830 to 2550 m/s. However, the SPH simulations failed to predict the crater depth for impact velocities greater than 1.5 km/s. The current paper will detail the results of parametric studies conducted using various existing models in an attempt to simulate the observed damage and the efforts to improve the simulation prediction of the experimental data. C1 [Fountzoulas, Costas G.; Gazonas, George A.; Cheeseman, Bryan A.] USA, Res Lab, Weapons & Mat Directorate, Adelphi, MD 20783 USA. RP Fountzoulas, CG (reprint author), USA, Res Lab, Weapons & Mat Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM cfount@arl.army.mil; gazonas@arl.army.mil; bcheesem@arl.army.mil OI Gazonas, George/0000-0002-2715-016X NR 18 TC 2 Z9 3 U1 1 U2 6 PU MATHEMATICAL SCIENCE PUBL PI BERKELEY PA UNIV CALIFORNIA, DEPT MATHEMATICS, BERKELEY, CA 94720-3840 USA SN 1559-3959 J9 J MECH MATER STRUCT JI J. Mech. Mater. Struct. PD DEC PY 2007 VL 2 IS 10 BP 1965 EP 1979 DI 10.2140/jomms.2007.2.1965 PG 15 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA 309CP UT WOS:000256438600006 ER PT J AU Berini, CA Pando, MA Bautista, CT Eirin, ME Martinez-Peralta, L Weissenbacher, M Avila, MM Biglione, MM AF Berini, Carolina A. Pando, Maria A. Bautista, Christian T. Eirin, Maria E. Martinez-Peralta, Liliana Weissenbacher, Mercedes Avila, Maria M. Biglione, Mirna M. TI HTLV-1/2 among high-risk groups in Argentina: Molecular diagnosis and prevalence of different sexual transmitted infections SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE co-infections; IDU; FSW; STI; tuberculosis; MSM ID VIRUS TYPE-I; HUMAN-IMMUNODEFICIENCY-VIRUS; INJECTING DRUG-USERS; T-CELL LEUKEMIA; BUENOS-AIRES; I/II; COINFECTION; EPIDEMIOLOGY; INDIVIDUALS; HIV-1 AB The objectives of this study were to estimate the prevalence and characterize the epidemiologic patterns of HTLV-1/2 infections and co-infections with HIV, HBV (hepatitis B), HCV (hepatitis C), and Treponema Pallidum in five different high-risk groups, including injecting drug users (IDUs), female sex workers (FSWs), men who have sex with men (MSM), patients with tuberculosis (TB), and patients attending clinics for sexually transmitted infections (STIs) in Buenos Aires, Argentina. The HTLV-1/2 prevalence was 19.1% (33/173) for IDUs, 2.0% (10/613) for FSWs, 2.1% (4/187) for TB, 1.0% (4/400) for STIs and 0.4% (3/282) for MSM, respectively. Among all groups, the higher percentages of co-infection were HTLV-1/HBV (63%, 17/27) and HTLV-1/HCV (52%, 14/27). Among IDUs, there was a high percentage of co-infection of HTLV-2 with HCV (96.3%, 26/27), HIV (92.6%, 25/27), and HBV (77.8%, 21/27), respectively. In summary, HTLV-1/2 infections appear to be widely distributed among high-risk groups in a nonendemic area of Argentina being the co-infection with HBV and HCV more frequent among IDUs. C1 Univ Buenos Aires, Fac Med, Dept Microbiol Parasitol & Immunol, Ctr Nac Referencia SIDA, Buenos Aires C1121ABG, DF, Argentina. Walter Reed Army Inst Res, US Mil HIV Res Prog, Rockville, MD USA. WRAIR, US Dept Defence Global Emerging Infect Surveillan, Silver Spring, MD USA. Henry M Jackson Fdn, Adv Military Med Inc, Rockville, MD USA. RP Berini, CA (reprint author), Univ Buenos Aires, Fac Med, Dept Microbiol Parasitol & Immunol, Ctr Nac Referencia SIDA, Paraguay 2155,Piso 11, Buenos Aires C1121ABG, DF, Argentina. EM cberini@fmed.uba.ar RI Bautista, Christian/B-2812-2011 NR 31 TC 8 Z9 8 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0146-6615 EI 1096-9071 J9 J MED VIROL JI J. Med. Virol. PD DEC PY 2007 VL 79 IS 12 BP 1914 EP 1920 DI 10.1002/jmv.21036 PG 7 WC Virology SC Virology GA 222TC UT WOS:000250319100018 PM 17935172 ER PT J AU Rushing, EJ Cooper, PB Quezado, M Begnami, M Crespo, A Smirniotopoulos, JG Ecklund, J Olsen, C Santi, M AF Rushing, Elisabeth J. Cooper, Patrick B. Quezado, Martha Begnami, Maria Crespo, Ana Smirniotopoulos, James G. Ecklund, James Olsen, Cara Santi, Mariarita TI Subependymoma revisited: clinicopathological evaluation of 83 cases SO JOURNAL OF NEURO-ONCOLOGY LA English DT Article DE central nervous system; CISH; CT; ependymoma; MRI; subependymoma ID SYMPTOMATIC SUBEPENDYMOMA; MR MANIFESTATIONS; IMAGING FEATURES; 14 TUMORS; EPENDYMOMAS; CT; NEOPLASMS AB Object Subependymomas are rare ependymal neoplasms. To date, a large clinicopathologic study of these benign neoplasms treated with modern neurosurgical techniques has not been reported. Methods Eighty-three cases of subependymoma were retrieved from the files of the Armed Forces Institute of Pathology. Clinicopathological features were reviewed; chromogenic in situ hybridization analysis for chromosome 22 was performed (n = 8), and patient follow-up was obtained (n = 34). Overall, the patients included 68 males and 15 females, 1.5 to 85 years of age (mean, 51.0 years). Twenty-seven cases were discovered at autopsy and the remaining were surgical specimens (n = 56). Tumors arose in the posterior fossa (n = 43), lateral ventricles (n = 37), spinal cord (2) and only one arose in the temporal horn. Tumors ranged in size from 2.0 mm to 60 mm in greatest dimension (mean, 23.0 mm). Eighteen-percent (15/83) of subependymomas exhibited a mixed histologic pattern; that is, subependymoma together with another glial tumor. The most common mixture (13/15) was subependymoma and ependymoma. Surgical excision was used in all symptomatic patients; 10 patients received radiation. Four patients developed a recurrence due to incomplete excision. All patients were without evidence of disease at the last follow-up: alive (n = 28) or dead (n = 8). Conclusions Age is the only variable found to be significantly associated with survival. Currently, surgical methods result in an excellent long-term clinical outcome. Subependymomas do not appear to be associated with NF2 mutations. C1 Armed Forces Inst Pathol, Dept Neuropathol, Washington, DC 20306 USA. Armed Forces Inst Pathol, Dept Ophthalm Pathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Natl Capitol Consortium, Dept Neurosurg, Bethesda, MD USA. NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA. Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol Sci, Bethesda, MD 20814 USA. Natl Childrens Hosp, Med Ctr, Dept Pathol, Washington, DC USA. RP Rushing, EJ (reprint author), Armed Forces Inst Pathol, Dept Neuropathol, Washington, DC 20306 USA. EM rushinge@afip.osd.mil RI Smirniotopoulos, James/D-3726-2011; Begnami, Maria/D-9663-2012 OI Begnami, Maria/0000-0003-0848-7813 NR 26 TC 33 Z9 36 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0167-594X J9 J NEURO-ONCOL JI J. Neuro-Oncol. PD DEC PY 2007 VL 85 IS 3 BP 297 EP 305 DI 10.1007/s11060-007-9411-6 PG 9 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA 231AY UT WOS:000250920000010 PM 17569000 ER PT J AU Weber, ED Colyer, MH Lesser, RL Subramanian, PS AF Weber, Eric D. Colyer, Marcus H. Lesser, Robert L. Subramanian, Prem S. TI Posterior ischemic optic neuropathy after minimally invasive prostatectomy SO JOURNAL OF NEURO-OPHTHALMOLOGY LA English DT Article ID RADICAL PROSTATECTOMY AB Two patients developed postoperative ischemic optic neuropathy (ION) after laparoscopic radical prostatectomy. One operation was robotically assisted; the other was performed with the conventional laparoscopic technique. These new minimally invasive techniques offer many advantages, but they require steep supine head-flexed (Trendelenburg) positioning. Until they are mastered by surgeons, operative times may be prolonged beyond those associated with the traditional technique. As a result, ION may occur more frequently. C1 [Weber, Eric D.; Colyer, Marcus H.; Subramanian, Prem S.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. [Lesser, Robert L.] Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, New Haven, CT 06510 USA. [Lesser, Robert L.] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA. [Subramanian, Prem S.] Uniformed Serv Univ Hlth Sci, Div Ophthalmol, Bethesda, MD 20814 USA. RP Subramanian, PS (reprint author), Wilmer Eye Inst, Wilmer B-31,600 N Wolfe St, Baltimore, MD 21287 USA. EM psubram1@jhmi.edu OI Subramanian, Prem/0000-0001-5824-8322 NR 8 TC 45 Z9 47 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1070-8022 J9 J NEURO-OPHTHALMOL JI J. Neuro-Ophthal. PD DEC PY 2007 VL 27 IS 4 BP 285 EP 287 PG 3 WC Clinical Neurology; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA 240MH UT WOS:000251591200008 PM 18090562 ER PT J AU Scrimgeour, AG Stahl, CH McClung, JP Marchitelli, LJ Young, AJ AF Scrimgeour, Angus G. Stahl, Chad H. McClung, James P. Marchitelli, Louis J. Young, Andrew J. TI Moderate zinc deficiency negatively affects biomechanical properties of rat tibiae independently of body composition SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE zinc; DXA; bone mineral density; rat ID BONE-MINERAL DENSITY; GROWING RATS; ALKALINE-PHOSPHATASE; BIOCHEMICAL MARKERS; RHESUS-MONKEYS; GROWTH; SUPPLEMENTATION; OSTEOPOROSIS; WOMEN; MEN AB To guide development of novel nutritional strategies aimed at reducing the incidence of stress fractures, we observed the effects of manipulating dietary zinc (Zn) content on bone integrity in Sprague-Dawley rats fed either a severely Zn-deficient (ZnD; 1 ppm), a moderately Zn-deficient (MZnD; 5 ppm) or a Zn-adequate (ZnAD; 30 ppm) diet for 6 weeks. At the completion of the diet period, body composition, bone mineral content (BMC), bone area (BA) and bone mineral density (BMD) were determined in vivo by using dual-energy X-ray absorptiometry. Following euthanasia, long bones were collected for determination of Zn content and biomechanical strength testing. Despite significant positive correlations between dietary Zn and both body weight (BW) and bone Zn content for the entire cohort (r = .77 and r = .83, respectively), rats fed MZnD or ZnAD diets did not differ in feed intakes, body composition, BMC, BA, BMD or BW Tibial bones, but not femur bones, appear to be more responsive to dietary Zn manipulation, as all bone biomechanical strength indices in the ZnAD-fed rats were significantly greater than in rats fed the ZnD diets. Rats fed either MZnD or ZnAD diets had stronger tibiae (129% increase in maximum load and stress at maximum load, P < .01) compared with those fed ZnD diets. The load at breakage for the tibial bones of rats fed MZnD diets was not different from the ZnD rats, but lower (P < .05) than that of the ZnAD rats. These results suggest that since feed intakes, body composition, BMC, BA, BMD and BW were not significantly different between the MZnD- and ZnAD-fed animals, the reduced bone integrity observed in the MZnD-fed rats resulted from dietary Zn inadequacy, and not as a result of the reduced growth that is typically associated with Zn deficiency. (c) 2007 Elsevier Inc. All rights reserved. C1 [Scrimgeour, Angus G.; McClung, James P.; Marchitelli, Louis J.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Stahl, Chad H.] Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA. RP Scrimgeour, AG (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM angus.scrimgeour@us.army.mil RI Scrimgeour, Angus/D-6794-2013; McClung, James/A-1989-2009 NR 50 TC 23 Z9 23 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0955-2863 J9 J NUTR BIOCHEM JI J. Nutr. Biochem. PD DEC PY 2007 VL 18 IS 12 BP 813 EP 819 DI 10.1016/j.jnutbio.2006.12.018 PG 7 WC Biochemistry & Molecular Biology; Nutrition & Dietetics SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA 242CJ UT WOS:000251701800006 PM 17475464 ER PT J AU Hoffmann, T Finger, D AF Hoffmann, Thomas Finger, David TI Chronic recurrent multifocal osteomyelitis SO JOURNAL OF RHEUMATOLOGY LA English DT Editorial Material C1 Tripler Army Med Ctr, APO, AP 96376 USA. RP Hoffmann, T (reprint author), Tripler Army Med Ctr, PSC 560 Box 856, APO, AP 96376 USA. EM thomas.hoffmann@us.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD DEC PY 2007 VL 34 IS 12 BP 2499 EP 2500 PG 2 WC Rheumatology SC Rheumatology GA 237UG UT WOS:000251401300033 PM 18061969 ER PT J AU Killgore, WDS Richards, JM Killgore, DB Kamimori, GH Balkin, TJ AF Killgore, William D. S. Richards, Jessica M. Killgore, Desiree B. Kamimori, Gary H. Balkin, Thomas J. TI The trait of Introversion-Extraversion predicts vulnerability to sleep deprivation SO JOURNAL OF SLEEP RESEARCH LA English DT Article DE Extraversion; individual differences; Introversion; personality; psychomotor vigilance; sleep deprivation ID NEO-PI-R; CEREBRAL-BLOOD-FLOW; INDIVIDUAL-DIFFERENCES; PERSONALITY-INVENTORY; PSYCHOMOTOR VIGILANCE; PERFORMANCE; ADOLESCENTS; RELIABILITY; ACTIVATION; RESPONSES AB According to Eysenck's theory of Introversion-Extroversion (I-E), introverts demonstrate higher levels of basal activity within the reticular-thalamic-cortical loop, yielding higher tonic cortical arousal than Extraverts, who are described conversely as chronically under-aroused and easily bored. We hypothesized that higher scores on the trait of Extraversion would be associated with greater declines in psychomotor vigilance performance during prolonged wakefulness. We evaluated the relationship between I-E and overnight psychomotor vigilance performance during 77 h of continuous sleep deprivation in a sample of 23 healthy adult military personnel (19 men; four women), ranging in age from 20 to 35 years. At baseline, volunteers completed the Revised NEO Personality Inventory (NEO PI-R) and completed psychomotor vigilance testing at approximately 10-min intervals from 00:15 to 08:50 hours over three nights of continuous sleep deprivation. In addition, 12 participants received four repeated administrations of caffeine (200 mg) every 2 h each night. Analysis of covariance and stepwise multiple regression analyses showed that, above and beyond the effects of caffeine, higher Extraversion was significantly related to more extensive declines in speed of responding and more frequent attentional lapses, but only for the first overnight testing session. Sub-factors of Extraversion, including Gregariousness and higher Activity level were most predictive of these changes following sleep loss. These findings are consistent with Eysenck's cortico-reticular activation theory of I-E and suggest that individual differences in the trait of Extraversion confer some vulnerability/resistance to the adverse effects of sleep loss on attention and vigilance. C1 Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Killgore, WDS (reprint author), McLean Hosp, Brain Imaging Ctr, Cognit Neuroimaging Lab, 115 Mill St, Belmont, MA 02478 USA. EM Killgore@mclean.harvard.edu NR 42 TC 21 Z9 22 U1 2 U2 25 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD DEC PY 2007 VL 16 IS 4 BP 354 EP 363 DI 10.1111/j.1365-2869.2007.00611.x PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 234ZM UT WOS:000251203300003 PM 18036080 ER PT J AU Li, Q Ayers, PD Anderson, AB AF Li, Q. Ayers, P. D. Anderson, A. B. TI Modeling of terrain impact caused by tracked vehicles SO JOURNAL OF TERRAMECHANICS LA English DT Article DE tracked vehicle; disturbed width; impact severity; turning radius ID VEGETATION AB Analytical models that can predict the terrain impact caused by tracked vehicles on a horizontal plane were developed and tested. The models included a disturbed width model and an impact severity model. Inputs of the terrain impact models included vehicle static properties, vehicle dynamic properties, and terrain properties. The tested vehicles included an M1A1 tank, an M577 Armored Personal Carrier (APC), and an M548 cargo carrier. The models were verified with field tests conducted in Yakima Training Center in Yakima, WA, Fort Riley, KS, and Camp Atterbury, Indiana. The average percentage errors of the disturbed width model for the M1A1, M577, and the M548 were 10.0%, 27.3%, and 8.5%, respectively. The average percentage errors of the impact severity model of the M1A1 and M577 were 25.0% and 21.4%, respectively. (C) 2007 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 [Li, Q.; Ayers, P. D.] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA. [Anderson, A. B.] USA, Erdc, Construct Engn Res Lab, Champaign, IL 61821 USA. RP Ayers, PD (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, 2506 EJ Chapman Dr, Knoxville, TN 37996 USA. EM ayers@utk.edu RI Li, Qinghe/D-6747-2011 NR 21 TC 6 Z9 8 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD DEC PY 2007 VL 44 IS 6 BP 395 EP 410 DI 10.1016/j.jterra.2007.09.001 PG 16 WC Engineering, Environmental SC Engineering GA 322CG UT WOS:000257352200001 ER PT J AU Wilson, DK Greenfield, RJ White, MJ AF Wilson, D. Keith Greenfield, Roy J. White, Michael J. TI Spatial structure of low-frequency wind noise SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID MICROPHONE; MECHANISMS AB The distinguishing spatial properties of low-frequency microphone wind noise (turbulent pressure disturbances) are examined with a planar, 49-element array. Individual, propagating transient pressure disturbances are imaged by wavelet processing to the array data. Within a given frequency range, the wind disturbances are much smaller and less spatially coherent than sound waves. Conventional array processing techniques are particularly sensitive to wind noise when sensor separations are small compared to the acoustic wavelengths of interest. (c) 2007 Acoustical Society of America C1 [Wilson, D. Keith; Greenfield, Roy J.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [White, Michael J.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Wilson, DK (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM d.keith.wilson@erdc.usace.army.mil; roy@essc.psu.edu; michael.j.white@erdc.usace.army.mil RI White, Michael/B-3612-2009; Wilson, D. Keith/A-4687-2012 OI White, Michael/0000-0001-8450-9135; Wilson, D. Keith/0000-0002-8020-6871 NR 7 TC 4 Z9 4 U1 0 U2 9 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD DEC PY 2007 VL 122 IS 6 BP EL223 EP EL228 DI 10.1121/1.2786608 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 241IS UT WOS:000251650700060 PM 18247645 ER PT J AU Noordzij, JP Lee, SL Bernet, VJ Payne, RJ Cohen, SM McLeod, IK Hier, MP Black, MJ Kerr, PD Richards, ML Lo, CY Raffaelli, M Bellantone, R Lombardi, CP Cohen, JI Dietrich, MS AF Noordzij, J. Pieter Lee, Stephanie L. Bernet, Victor J. Payne, Richard J. Cohen, Seth M. McLeod, Ian K. Hier, Michael P. Black, Martin J. Kerr, Paul D. Richards, Melanie L. Lo, Chung Yau Raffaelli, Marco Bellantone, Rocco Lombardi, Celestino P. Cohen, James I. Dietrich, Mary S. TI Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: An analysis of pooled individual patient data from nine observational studies SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID POSTTHYROIDECTOMY HYPOCALCEMIA; CALCIUM LEVELS; SURGERY; ASSAY; HYPERPARATHYROIDISM; MANAGEMENT; UTILITY; LEVEL AB BACKGROUND: Monitoring for hypocalcemia after thyroidectomy, using only symptoms and serum calcium levels, can delay the discharge of patients who will remain normocalcemic and can delay the treatment of hypocalcemic patients. STUDY DESIGN: We conducted a systematic search for articles describing use of parathyroid hormone (PTH) assay, checked within hours of completing thyroidectomy, to predict postoperative symptomatic hypocalcemia. Studies were excluded if all patients were treated with postoperative calcium, or if early PTH values were used to alter management of the patient. Individual patient data (perioperative PTH and calcium levels, development of hypocalcemia) were obtained for 457 patients from the corresponding authors of 9 studies and pooled to yield the following results. RESULTS: PTH, checked at three time periods after removal of the thyroid gland (0 to 20 minutes, I to 2 hours, and 6 hours), was substantially lower in patients who became hypocalcemic compared with those who remained normocalcemic. The accuracy of PTH in determining hypocalcemia increased with time and was excellent when checked I to 6 hours postoperatively. A single PTH threshold (65% decrease compared with preoperative level), checked 6 hours after completing thyroidectomy, had a sensitivity of 96.4% and specificity of 91.4% in detecting postoperative hypocalcemia. CONCLUSIONS: PTH assay, when checked I to 6 hours after thyroidectomy, has excellent accuracy in determining which patients will become symptomatically hypocalcemic. Routine use of this assay should be considered because it may allow earlier discharge of the normocalcemic patient and earlier identification of patients requiring treatment of postthyroidectomy hypocalcemia. C1 Boston Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Boston, MA USA. Boston Univ, Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA USA. Walter Reed Army Med Ctr, Dept Endocrinol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. McGill Univ, Jewish Gen Hosp, Dept Otolaryngol Head & Neck Surg, Montreal, PQ H3T 1E2, Canada. Duke Univ, Div Otolaryngol Head & Neck Surg, Durham, NC USA. Univ Manitoba, Dept Otolaryngol, Winnipeg, MB, Canada. Mayo Clin, Dept Surg, Rochester, MN USA. Univ Hong Kong, Med Ctr, Queen Mary Hosp, Dept Surg, Hong Kong, Hong Kong, Peoples R China. Univ Cattolica Sacro Cuore, Dept Surg, Div Endocrine Surg, Rome, Italy. Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. Vanderbilt Univ, Sch Nursing, Nashville, TN 37240 USA. Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA. RP Noordzij, JP (reprint author), 88 E Newton St,D608, Boston, MA 02118 USA. EM pieter.noordzij@bmc.org OI Lee, Stephanie/0000-0002-4179-6653 NR 29 TC 71 Z9 77 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD DEC PY 2007 VL 205 IS 6 BP 748 EP 754 DI 10.1016/j.jamcollsurg.2007.06.298 PG 7 WC Surgery SC Surgery GA 238IC UT WOS:000251439800004 PM 18035257 ER PT J AU Butler, RN AF Butler, Robert N. TI Thoughts on the development of geriatrics SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY LA English DT Editorial Material C1 USA, Int Longev Ctr, New York, NY USA. RP Butler, RN (reprint author), USA, Int Longev Ctr, 60 E 86th St, New York, NY USA. NR 2 TC 5 Z9 5 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-8614 J9 J AM GERIATR SOC JI J. Am. Geriatr. Soc. PD DEC PY 2007 VL 55 IS 12 BP 2086 EP 2087 DI 10.1111/j.1532-5415.2007.01520.x PG 2 WC Geriatrics & Gerontology; Gerontology SC Geriatrics & Gerontology GA 238FV UT WOS:000251433700029 PM 18081676 ER PT J AU Turell, MJ Lee, JS Richardson, JH Sang, RC Kioko, EN Agawo, MO Pecor, J O'Guinn, ML AF Turell, M. J. Lee, J. S. Richardson, J. H. Sang, R. C. Kioko, E. N. Agawo, M. O. Pecor, J. O'Guinn, M. L. TI Vector competence of Kenyan Culex zombaensis and Culex quinquefasciatus mosquitoes for Rift Valley fever virus SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Kenya; Culex zombaensis; Culex quinquefasciatus; rift valley fever virus; transmission ID SAUDI-ARABIA; PHLEBOTOMUS-DUBOSCQI; SOUTH-AFRICA; SAND FLY; DIPTERA; TRANSMISSION; OUTBREAK; CULICIDAE; EPIDEMIC; PIPIENS AB Rift Valley fever (RVF) continues to be a significant problem in Kenya as well as in Egypt, Yemen, and Saudi Arabia. In order to determine the ability of Kenyan mosquitoes to transmit RVF virus (RVFV), we collected mosquitoes in the Lake Naivasha region of Kenya and evaluated them for their potential to transmit RVFV under laboratory conditions. After feeding on a hamster (Mesocricetus auratus) with a viremia of 10(9.7) plaque-forming units of virus/ml of blood, Culex zombaensis were highly susceptible to infection with RVFV, with 89% becoming infected. In contrast, Cx. quinquefasciatus that were fed on the same hamsters were marginally susceptible, with only 20% becoming infected. Differences in percentages of mosquitoes that developed a disseminated infection were equally disparate, with 55% and 8%, for Cx. zombaensis and Cx. quinquefasciatus, respectively. Forty-eight percent of the Cx. zombaensis with a disseminated infection that fed on a susceptible hamster transmitted virus by bite, indicating a moderate salivary gland barrier. However, the presence of a salivary gland barrier could not be determined for Cx. quinquefasciatus because none of the 18 mosquitoes that took a 2nd blood meal had a disseminated infection. These studies illustrate the need to identify the ability of individual mosquito species to transmit RVFV so that correct decisions can be made concerning the application of appropriate control measures during an outbreak. C1 [Turell, M. J.; Lee, J. S.; O'Guinn, M. L.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Richardson, J. H.; Kioko, E. N.; Agawo, M. O.] USA, Med Res Unit, Dept Entomol & Vector Borne Dis, Nairobi, Kenya. [Sang, R. C.] Ctr Virus Res, Kenya Med Res Inst, VHF Lab, Nairobi, Kenya. [Pecor, J.] Walter Reed Army Inst Res, Dept Entomol, Washington, DC 20307 USA. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. RI Richardson, Jason/A-9441-2011; Valle, Ruben/A-7512-2013 NR 34 TC 24 Z9 24 U1 0 U2 5 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2007 VL 23 IS 4 BP 378 EP 382 DI 10.2987/5645.1 PG 5 WC Entomology SC Entomology GA 243YH UT WOS:000251832700002 PM 18240513 ER PT J AU Hurst, FP Bohen, EM Osgard, EM Oliver, DK Das, NP Gao, SW Abbott, KC AF Hurst, Frank P. Bohen, Erin M. Osgard, Eric M. Oliver, David K. Das, Nealanjon P. Gao, Sam W. Abbott, Kevin C. TI Association of oral sodium phosphate purgative use with acute kidney injury SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ACUTE-RENAL-FAILURE; SERUM CREATININE; HYPERPHOSPHATEMIA; NEPHROPATHY; MORTALITY; LENGTH; STAY AB Oral sodium phosphate (OSP) is a commonly used purgative before colonoscopy. There have been numerous reports of acute phosphate nephropathy attributed to the use of OSP. This study evaluated the association between the use of OSP and acute kidney injury (AKI) in an observational, retrospective, cohort study. Of 9799 patients who underwent colonoscopy and had serum creatinine values recorded within 365 days before and after the procedure, AKI, defined as >= 50% increase in baseline serum creatinine, was identified in 114 (1.16%). After adjustment for significant covariates in a multiple logistic regression model, the use of OSP was associated with increased risk for AKI (odds ratio 2.35; 95% confidence interval 1.51 to 3.66; P < 0.001) with an adjusted number need to harm of 81. Age was also independently associated with AKI in this cohort; therefore, until larger, prospective studies define the population at risk for acute phosphate nephropathy, the use of polyethylene glycol-based purgatives should be considered for older patients and possibly for those with comorbid medical conditions. C1 [Hurst, Frank P.; Bohen, Erin M.; Oliver, David K.; Das, Nealanjon P.; Gao, Sam W.; Abbott, Kevin C.] USA, Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Osgard, Eric M.] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. [Osgard, Eric M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Hurst, FP (reprint author), USA, Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM frank.hurst@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 18 TC 61 Z9 62 U1 0 U2 1 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD DEC PY 2007 VL 18 IS 12 BP 3192 EP 3198 DI 10.1681/ASN.2007030349 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 241AG UT WOS:000251628700024 PM 17978311 ER PT J AU Lee, WT Russell, K AF Lee, Wen-Tzong Russell, Kevin TI On two-phase spherical motion generation SO JOURNAL OF THE CHINESE SOCIETY OF MECHANICAL ENGINEERS LA English DT Article DE adjustable spherical mechanism; motion generation ID 4-BAR MECHANISMS; KINEMATIC SYNTHESIS; PATH GENERATORS; PLANAR; DESIGN AB This work presents a method to design four revolute spherical mechanisms to approximate two phases of prescribed rigid-body positions. Using this method, four revolute spherical motion generators can be designed to approximate two phases of prescribed rigid-body positions using the same mechanism hardware. This work considers moving-pivot adjustable four revolute spherical motion generators with constant crank and follower lengths for two-phase motion generation. C1 [Lee, Wen-Tzong] Leader Univ, Dept Informat Management, Tainan 70970, Taiwan. [Russell, Kevin] USA, Ctr Res Dev & Engn, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. RP Lee, WT (reprint author), Leader Univ, Dept Informat Management, Tainan 70970, Taiwan. NR 23 TC 1 Z9 2 U1 0 U2 0 PU CHINESE SOC MECHANICAL ENGINEERS PI TAIPEI PA 4F NO 60 SEC 2 PA TE RD, TAIPEI, 10401, TAIWAN SN 0257-9731 J9 J CHIN SOC MECH ENG JI J. Chin. Soc. Mech. Eng. PD DEC PY 2007 VL 28 IS 6 BP 617 EP 622 PG 6 WC Engineering, Mechanical SC Engineering GA 294KM UT WOS:000255404900008 ER PT J AU Perconti, P Loew, MH AF Perconti, Philip Loew, Murray H. TI Salience measure for assessing scale-based features in mammograms SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID VISUAL-ATTENTION; EYE-POSITION; SPATIAL-FREQUENCY; REPORTED CANCERS; BREAST CANCERS; MODEL; SEARCH; PERCEPTION; IMAGES; ALLOCATION AB This work assesses the usefulness of an objective, task-based image quality measure that is correlated with perceived image quality; the measure uses the most salient features contained within a medical image. Contributions include the development of a perceptually correlated metric that is useful for quantifying the salience of local, low-level visual cues and identifying those spatial frequencies that are most distinct and perhaps most relied upon by radiologists for decision making. A set of 40 mammograms and registered eye position data from nine observers was used to evaluate the salience metric. A parsimonious analysis-of-variance model explained the variance in the salience results. This analysis is generalized to a population of readers and cases. An analysis of salience versus time of first eye fixation shows good correlation with true positive lesions that were found by experienced readers in less than 2 s. (C) 2007 Optical Society of America. C1 [Perconti, Philip] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Loew, Murray H.] George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20052 USA. RP Perconti, P (reprint author), USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM philip.perconti@us.army.mil NR 51 TC 1 Z9 1 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD DEC PY 2007 VL 24 IS 12 BP B81 EP B90 DI 10.1364/JOSAA.24.000B81 PG 10 WC Optics SC Optics GA 248BP UT WOS:000252126600009 PM 18059917 ER PT J AU Wright, KM Bliese, PD Thomas, JL Adler, AB Eckford, RD Hoge, CW AF Wright, Kathleen M. Bliese, Paul D. Thomas, Jeffrey L. Adler, Amy B. Eckford, Rachel D. Hoge, Charles W. TI Contrasting approaches to psychological screening with US combat soldiers SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; DSM-IV; PTSD CHECKLIST; PRIMARY-CARE; POPULATION; DEPRESSION; CRITERION; VALIDATION; INSTRUMENT; DISTRESS AB Psychological screening can be conducted using global screens, single items, symptom-based scales, or composite measures. These four different approaches were evaluated against structured clinical interviews in studies with U.S. soldiers preparing to deploy and returning from combat operations in Iraq. Three samples (N = 337, N = 574, and N = 348) were screened to assess the effectiveness of a short global measure of distress, a single self-referral item, symptom-specific scales selected for the target population, and a composite instrument that included a combination of clinical domains. A composite screen with measures of posttraumatic stress, depression, and alcohol problems, along with a single self-referral item, performed most effectively. C1 [Wright, Kathleen M.; Bliese, Paul D.; Adler, Amy B.; Eckford, Rachel D.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. [Thomas, Jeffrey L.; Hoge, Charles W.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. RP Wright, KM (reprint author), CMR 442,Box 94, APO, AE 09042 USA. EM kathleen.wright@us.army.mil NR 34 TC 16 Z9 16 U1 1 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD DEC PY 2007 VL 20 IS 6 BP 965 EP 975 DI 10.1002/jts.20279 PG 11 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 245RG UT WOS:000251952900005 PM 18157884 ER PT J AU Pugliese, JM Morey, AF Peterson, AC AF Pugliese, Jennifer M. Morey, Allen F. Peterson, Andrew C. TI Lichen sclerosus: Review of the literature and current recommendations for management SO JOURNAL OF UROLOGY LA English DT Review DE lichen sclerosus et atrophicus; balanitis xerotica obliterans; urethral stricture ID BALANITIS XEROTICA OBLITERANS; SQUAMOUS-CELL CARCINOMA; ET-ATROPHICUS; URETHRAL RECONSTRUCTION; TOPICAL TESTOSTERONE; HUMAN-PAPILLOMAVIRUS; KOEBNER PHENOMENON; ACITRETIN; DYSTROPHY; STRICTURE AB Purpose: We reviewed the literature regarding the clinical presentation, etiology, natural history, and medical and surgical management of lichen sclerosus in men. Materials and Methods: We performed a comprehensive search of the literature in PubMed, MEDLINE(R) and other electronic databases between 1950 and 2006 using the key words lichen sclerosis, balanitis xerotica obliterans and urethral stricture. Our search resulted in 1,268 sources containing the words lichen sclerosus or balanitis xerotica obliterans. We reviewed 68 articles in the peer reviewed journals and 2 chapters on this subject. Results: Lichen sclerosus is a chronic, lymphocyte mediated skin disease that was first described in 1887. It shows a predilection for the anogenital area in men and women. Much has been discovered regarding the epidemiology, natural history and histological features of this disease process during the last century, including the discovery of a strong association between lichen sclerosus and squamous cell carcinoma. The techniques of medical and surgical management of this disorder are still being elucidated. Biopsy of the initial lesion for definitive diagnosis and long-term followup of affected patients are well established, critical elements in the management of lichen sclerosus. Conclusions: Lichen sclerosus is a chronic, debilitating condition that may progress to cause significant voiding complications. Biopsy is recommended in all patients suspected of having lichen sclerosus to rule out squamous cell carcinoma. Further research is needed to improve the prevention, understanding and treatment of this challenging condition. C1 Madigan Army Med Ctr, Dept Surg, Urol Serv, Tacoma, WA 98431 USA. Brooke Army Med Ctr, Dept Surg, Urol Serv, San Antonio, TX USA. RP Peterson, AC (reprint author), Madigan Army Med Ctr, Dept Surg, Urol Serv, Tacoma, WA 98431 USA. EM peterson@us.army.mil NR 55 TC 95 Z9 106 U1 2 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD DEC PY 2007 VL 178 IS 6 BP 2268 EP 2276 DI 10.1016/j.juro.2007.08.024 PG 9 WC Urology & Nephrology SC Urology & Nephrology GA 230AO UT WOS:000250847900007 PM 17936829 ER PT J AU Meissner, MH Wakefield, TW Ascher, E Caprini, JA Comerota, AJ Eklof, B Gillespie, DL Greenfield, LJ Ruth, A Henke, PK Hingorani, A Hull, RD Kessler, CM McBane, RD McLafferty, R AF Meissner, Mark H. Wakefield, Thomas W. Ascher, Enrico Caprini, Joseph A. Comerota, Anthony J. Eklof, Bo Gillespie, David L. Greenfield, Lazar J. Ruth, Aiwu Henke, Peter K. Hingorani, Anil Hull, Russell D. Kessler, Craig M. McBane, Robert D. McLafferty, Robert TI Acute venous disease: Venous thrombosis and venous trauma SO JOURNAL OF VASCULAR SURGERY LA English DT Review ID DEEP-VEIN-THROMBOSIS; FACTOR-V-LEIDEN; LOWER-EXTREMITY DEEP; TISSUE-PLASMINOGEN ACTIVATOR; ORAL ANTICOAGULANT-THERAPY; VASCULAR INJURY MANAGEMENT; PHLEGMASIA CERULEA DOLENS; MOLECULAR-WEIGHT HEPARIN; VENA-CAVA FILTERS; PULMONARY-EMBOLISM AB Acute venous disorders include deep venous thrombosis, superficial venous thrombophlebitis, and venous trauma. Deep venous thrombosis (DVT) most often arises from the convergence of multiple genetic and acquired risk factors, with a variable estimated incidence of 56 to 160 cases per 100,000 population per year. Acute thrombosis is followed by an inflammatory response in the thrombus and vein wall leading to thrombus amplification, organization, and recanalization. Clinically, there is an exponential decrease in thrombus load over the first 6 months, with most recanalization occurring over the first 6 weeks after thrombosis. Pulmonary embolism (PE) and the post-thrombotic syndrome (PTS) are the most important acute and chronic complications of DVT. Despite the effectiveness of thromboembolism prophylaxis, appropriate measures are utilized in as few as one-third of at-risk patients. Once established, the treatment of venous thromboembolism (VTE) has been defined by randomized clinical trials, with appropriate anticoagulation constituting the mainstay of management. Despite its effectiveness in preventing recurrent VTE, anticoagulation alone imperfectly protects against PTS. Although randomized trials are currently lacking, at least some data suggests that catheter-directed thrombolysis or combined pharmaco-mechanical thrombectomy can reduce post-thrombotic symptoms and improve quality of life after acute ileofemoral DVT. Inferior vena caval filters continue to have a role among patients with contra-indications to, complications of, or failure of anticoagulation. However, an expanded role for retrievable filters for relative indications has yet to be dearly established. The incidence of superficial venous thrombophlebitis is likely under-reported, but it occurs in approximately 125,000 patients per year in the United States. Although the appropriate treatment remains controversial, recent investigations suggest that anticoagulation may be more effective than ligation in preventing DVT and PE. Venous injuries are similarly under-reported and the true incidence is unknown. Current recommendations include repair of injuries to the major proximal veins. If repair not safe or possible, ligation should be performed. C1 [Wakefield, Thomas W.; Greenfield, Lazar J.; Henke, Peter K.] Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA. [Ascher, Enrico] Maimonides Hosp, Div Vasc Surg, Brooklyn, NY 11219 USA. [Caprini, Joseph A.] NW Univ, Sch Med, Dept Surg, Evanston, IL USA. [Comerota, Anthony J.] NW Univ, Sch Med, Dept Surg, Springfield, IL USA. [Eklof, Bo] Jobst Vasc Ctr, Toledo, OH USA. [Gillespie, David L.] Straub Fdn, Helsingborg, Sweden. [Hull, Russell D.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Potomac, MD USA. [McBane, Robert D.] Georgetown Univ, Med Ctr, Div Hematol Oncol, Ann Arbor, MI USA. [McLafferty, Robert] Georgetown Univ, Med Ctr, Dept Surg, Washington, DC 20007 USA. [Meissner, Mark H.] Univ Washington, Sch Med, Dept Surg, Seattle, WA 98195 USA. Mayo Clin, Gonda Vasc Ctr, Rochester, MN USA. So Illinois Univ, Dept Surg, Carbondale, IL 62901 USA. Thrombosis Res Unit, Calgary, AB, Canada. RP Meissner, MH (reprint author), Univ Washington, Med Ctr, Dept Surg, Box 356410,1589 NE Pacific St, Seattle, WA 98195 USA. EM meissner@u.washington.edu OI Gillespie, David/0000-0002-4378-9465 NR 256 TC 32 Z9 43 U1 2 U2 9 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD DEC PY 2007 VL 46 SU S BP 25S EP 53S DI 10.1016/j.jvs.2007.08.037 PG 29 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 243NB UT WOS:000251803500003 PM 18068560 ER PT J AU Meissner, MH Gloviczki, P Bergan, J Kistner, RL Morrison, N Pannier, F Pappas, PJ Rabe, E Raju, S Villavicencio, JL AF Meissner, Mark H. Gloviczki, Peter Bergan, John Kistner, Robert L. Morrison, Nick Pannier, Felizitas Pappas, Peter J. Rabe, Eberhard Raju, Seshadri Villavicencio, J. Leonel TI Primary chronic venous disorders SO JOURNAL OF VASCULAR SURGERY LA English DT Review ID ENDOVENOUS RADIOFREQUENCY OBLITERATION; RECURRENT VARICOSE-VEINS; GREATER SAPHENOUS-VEIN; 2-YEAR FOLLOW-UP; AIR PLETHYSMOGRAPHY; LASER TREATMENT; POSTTHROMBOTIC REFLUX; VALVE RECONSTRUCTION; OUTFLOW OBSTRUCTION; REPORTING STANDARDS AB Primary chronic venous disorders, which according to the CEAP classification are those not associated with an identifiable mechanism of venous dysfunction, are among the most common in Western populations. Varicose veins without skin changes are present in about 20% of the population while active ulcers may be present in as many as 0.5%. Primary venous disorders are thought to arise from intrinsic structural and biochemical abnormalities of the vein wall. Advanced cases may be associated with skin changes and ulceration arising from extravasation of macromolecules and red blood cells leading to endothelial cell activation, leukocyte diapedesis, and altered tissue remodeling with intense collagen deposition. Laboratory evaluation of patients with primary venous disorders includes venous duplex ultrasonography performed in the upright position, occasionally supplemented with plethysmography and, when deep venous reconstruction is contemplated, ascending and descending venography. Primary venous disease is most often associated with truncal saphenous insufficiency. Although historically treated with stripping of the saphenous vein and interruption and removal of major tributary and perforating veins, a variety of endovenous techniques are now available to ablate the saphenous veins and have generally been demonstrated to be safe and less morbid than traditional procedures. Sclerotherapy also has an important role in the management of telangiectasias; primary, residual, or recurrent varicosities without connection to incompetent venous trunks; and congenital venous malformations. The introduction of ultrasound guided foam sclerotherapy has broadened potential indications to include treatment of the main saphenous trunks, varicose tributaries, and perforating veins. Surgical repair of incompetent deep venous valves has been reported to be an effective procedure in nonrandomized series, but appropriate case selection is critical to successful outcomes. C1 [Gloviczki, Peter] Mayo Clin, Rochester, MN USA. [Bergan, John] Univ Calif San Diego, Sch Med, Scripps Mem Hosp, La Jolla, CA USA. [Kistner, Robert L.] Straub Fdn, Kistner Vein Clin, Honolulu, HI USA. [Morrison, Nick] Morrison Vein Inst, Scottsdale, AZ USA. [Rabe, Eberhard] Univ Bonn, D-5300 Bonn, Germany. [Pappas, Peter J.] Univ Med & Dent New Jersey, Newark, NJ 07103 USA. [Villavicencio, J. Leonel] Univ Sch Med, Walter Reed Army Med Ctr, Uniformed Serv, Bethesda, MD USA. [Villavicencio, J. Leonel] Natl Naval Med Ctr, Bethesda, MD USA. [Meissner, Mark H.] Univ Washington, Sch Med, Dept Surg, Seattle, WA 98195 USA. RP Meissner, MH (reprint author), Univ Washington, Med Ctr, Dept Surg, Box 356410,1589 NE Pacific St, Seattle, WA 98195 USA. NR 108 TC 67 Z9 70 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD DEC PY 2007 VL 46 SU S BP 54S EP 67S DI 10.1016/j.jvs.2007.08.038 PG 14 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 243NB UT WOS:000251803500004 PM 18068562 ER PT J AU Cox, MW Whittaker, DR Martinez, C Fox, CJ Feuerstein, IM Gillespie, DL AF Cox, Mitchell W. Whittaker, David R. Martinez, Christopher Fox, Charles J. Feuerstein, Irwin M. Gillespie, David L. TI Traumatic pseudoaneurysms of the head and neck: Early endovascular intervention SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT Spring Meeting of the Peripheral-Vascular-Surgery-Society CY JUN 07-09, 2007 CL Baltimore, MD SP Peripheral Vasc Surg Soc ID SUPERFICIAL TEMPORAL ARTERY; INTERNAL CAROTID-ARTERY; INJURIES; EMBOLIZATION; CT AB Background: Trauma to the head and neck with military munitions often presents with complex multisystem injury patterns. Vascular evaluation typically focuses on the carotid and vertebral arteries; however, trauma to branches of the external carotid artery may also result in devastating complications. Pseudoaneurysms are the most frequent finding on delayed evaluation and can result in life-threatening episodes of rebleeding. Methods: Patients evacuated from the Afghanistan and Iraq conflicts with penetrating injury to the face and neck were evaluated by the vascular surgery service to determine the potential for unsuspected vascular injury. Patients with significant penetrating injury underwent computed tomography angiography (CTA) as the initial evaluation and subsequent arteriography in cases where injuries were suspected or metallic fragments produced artifacts obscuring the vasculature. Data on all vascular evaluations were entered prospectively into a database and retrospectively reviewed. Results: Between February 2003 and March 2007, 124 patients were evaluated for significant penetrating trauma to the head and neck. Thirteen pseudoaneurysms of the head and neck were found in 11 patients: two in the internal carotid artery, one of the vertebral artery, and 10 involving branches of the external carotid. Seven pseudoaneurysms were symptomatic, of which two presented with episodes of massive bleeding and airway compromise. Seven pseudoaneurysms were treated with coil embolization, 1 with Gelfoam (Upjohn, Kalamazoo, Mich) embolization, 2 with stent grafts, 2 with open repair, and 1 with observation alone. None of the patients undergoing embolization had complications; however, a stent graft of the internal carotid artery occluded early, without stroke. All of the pseudoaneurysms had resolved on follow-up CTA or angiogram. Conclusions: Pseudoaneurysms are a common finding in patients with high-velocity gunshot wounds or blast injuries to the head and neck. Most involve branches of the external carotid artery and can be treated by embolization. CTA should be performed on all patients with high-velocity gunshot wounds or in cases of blast trauma with fragmentation injuries of the head and neck. C1 [Cox, Mitchell W.; Gillespie, David L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Whittaker, David R.] Natl Naval Med Ctr, Bethesda, MD 20889 USA. [Cox, Mitchell W.; Martinez, Christopher; Gillespie, David L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Cox, MW (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM mitchconnie@aol.com OI Gillespie, David/0000-0002-4378-9465 NR 15 TC 41 Z9 45 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD DEC PY 2007 VL 46 IS 6 BP 1227 EP 1233 DI 10.1016/j.jvs.2007.08.021 PG 7 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 241IG UT WOS:000251649500020 PM 18154999 ER PT J AU Robbins, RG Durden, LA AF Robbins, Richard G. Durden, Lance A. TI Robert Traub (1916-1996): additional publications and patronyms SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Robert Traub; publications; patronyms ID SIPHONAPTERA AB Full citations are provided for four posthumously published papers coauthored or inspired by the late Robert Traub, the greatest authority on fleas and flea-borne diseases who ever lived. Seven additional patronyms, five posthumous and two newly discovered, bring to 41 the total number of taxa named for this preeminent medical entomologist. C1 [Robbins, Richard G.] Walter Reed Army Med Ctr, Def Pest Management Informat Anal Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. [Durden, Lance A.] Georgia So Univ, Dept Biol, Statesboro, GA 30460 USA. [Durden, Lance A.] Georgia So Univ, Inst Arthropodol & Parasitol, Statesboro, GA 30460 USA. RP Robbins, RG (reprint author), Walter Reed Army Med Ctr, Def Pest Management Informat Anal Ctr, Armed Forces Pest Management Board, Washington, DC 20307 USA. NR 7 TC 0 Z9 1 U1 0 U2 0 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2007 VL 32 IS 2 BP 159 EP 160 DI 10.3376/1081-1710(2007)32[159:RTAPAP]2.0.CO;2 PG 2 WC Entomology SC Entomology GA 252WQ UT WOS:000252478300001 PM 18260502 ER PT J AU Zhou, Y Lukes, Y Anderson, J Fileta, B Reinhardt, B Sjogren, M AF Zhou, Y. Lukes, Y. Anderson, J. Fileta, B. Reinhardt, B. Sjogren, M. TI Hepatitis C virus E2 envelope protein induces dendritic cell maturation SO JOURNAL OF VIRAL HEPATITIS LA English DT Article DE dendritic cell; HCV e2; hepatitis C; T-cell activation ID INTERFERON-GAMMA PRODUCTION; CD8(+) T-CELLS; UNITED-STATES; DC-SIGN; IMMUNE-RESPONSES; VIRAL CLEARANCE; HELPER-CELLS; IN-VIVO; INFECTION; BINDING AB Maturation is a critical process for dendritic cells (DC) to gain or enhance their functions in antigen presentation and T-cell activation. In this study, we investigated the effect of hepatitis C virus (HCV) envelope protein E2 on DC maturation and related functions. We show that binding of E2 protein to DC leads to a change from immature to mature phenotype as detected by an increased expression of cell surface molecules including CD83, CD80, CD86, CD11c and MHC class II. The E2-matured DC showed higher capacity to stimulate T-cell proliferation and interferon-gamma production and displayed higher levels of interleukin-12 production when compared with immature DC. The induction of DC maturation by E2 is both time- and dose-dependent and can be inhibited by anti-E2 antibodies. In addition, DC matured by E2 showed decreased uptake of bovine serum albumin and latex beads, indicating their decreased activities of endocytosis and phagocytosis upon maturation. Taken together, our results demonstrated that E2 protein is able to induce dendritic cell maturation and suggested that E2 protein may play an important role in regulation of immune responses during HCV infection. C1 Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. RP Zhou, Y (reprint author), Walter Reed Army Med Ctr, Dept Clin Invest, 6900 Georgia Ave NW,Bldg 7,Room 201, Washington, DC 20307 USA. EM yaling.zhou@na.amedd.army.mil NR 49 TC 12 Z9 14 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1352-0504 J9 J VIRAL HEPATITIS JI J. Viral Hepatitis PD DEC PY 2007 VL 14 IS 12 BP 849 EP 858 DI 10.1111/j.1365-2893.2007.00879.x PG 10 WC Gastroenterology & Hepatology; Infectious Diseases; Virology SC Gastroenterology & Hepatology; Infectious Diseases; Virology GA 237LH UT WOS:000251374700005 PM 18070288 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Bill Mauldin: A life up front SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD DEC PY 2007 VL 132 IS 20 BP 127 EP 128 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 243GX UT WOS:000251784600182 ER PT J AU Cho, YM Smithenry, DW Ghosh, U Kennedy, AJ Millward, RN Bridges, TS Luthy, RG AF Cho, Yeo-Myoung Smithenry, Dennis W. Ghosh, Upal Kennedy, Alan J. Millward, Rod N. Bridges, Todd S. Luthy, Richard G. TI Field methods for amending marine sediment with activated carbon and assessing treatment effectiveness SO MARINE ENVIRONMENTAL RESEARCH LA English DT Article DE polychlorinated biphenyls; in situ treatment; bioavailability; activated carbon; sediments; San Francisco bay; USA; field validation ID POLYCHLORINATED-BIPHENYLS; PAH BIOAVAILABILITY; MACOMA-BALTHICA; REDUCE PCB AB Previous laboratory studies have shown reductions in PCB bioavailability for sediments amended with activated carbon (AC). Here we report results on a preliminary pilot-scale study to assess challenges in scaling-up for field deployment and monitoring. The goals of the preliminary pilot-scale study at Hunters Point Shipyard (San Francisco, USA) were to (1) test the capabilities of a large-scale mixing device for incorporating AC into sediment, (2) develop and evaluate our field assessment techniques, and (3) compare reductions in PCB bioavailability found in the laboratory with well-mixed systems to those observed in the field with one-time-mixed systems. In this study we successfully used a large-scale device to mix 500 kg of AC into a 34.4 m(2) plot to a depth of 1 ft, a depth that includes the majority of the biologically active zone. Our results indicate that after 7 months of AC-sediment contact in the field, the 28-day PCB bioaccumulation for the bent-nosed clam, Macoma nasuta, field-deployed to this AC-amended sediment was approximately half of the bioaccumulation resulting from exposure to untreated sediment. Similar PCB bioaccumulation reductions were found in laboratory bioassays conducted on both the bivalve, M. nasuta and the estuarine amphipod, Leptocheirus plumulosus, using sediment collected from the treated and untreated field plots one year after the AC amendment occurred. To further understand the long-term effectiveness of AC as an in situ treatment strategy for PCB-contaminated sediments under field conditions, a 3-year comprehensive study is currently underway at Hunters Point that will compare the effectiveness of two large-scale mixing devices and include both unmixed and mixed-only control plots. (c) 2007 Elsevier Ltd. All rights reserved. C1 Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. Santa Clara Univ, Dept Educ, Santa Clara, CA 95053 USA. Univ Maryland Baltimore Cty, Dept Civil & Environm Engn, Baltimore, MD 21250 USA. USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. Weston Solut, Tiburon, CA 94920 USA. RP Luthy, RG (reprint author), Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA. EM luthy@stanford.edu NR 20 TC 79 Z9 82 U1 1 U2 27 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-1136 J9 MAR ENVIRON RES JI Mar. Environ. Res. PD DEC PY 2007 VL 64 IS 5 BP 541 EP 555 DI 10.1016/j.marenvres.2007.04.006 PG 15 WC Environmental Sciences; Marine & Freshwater Biology; Toxicology SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Toxicology GA 234YT UT WOS:000251201400001 PM 17570482 ER PT J AU Rivard, RG Mccall, S Griffith, ME Hawley, JS Ressner, RA Borra, H Moon, JE Beckius, ML Murray, CK Hospenthal, DR AF Rivard, Robert G. Mccall, Suzanne Griffith, Matthew E. Hawley, Joshua S. Ressner, Roseanne A. Borra, Himabindu Moon, James E. Beckius, Miriam L. Murray, Clinton K. Hospenthal, Duane R. TI Efficacy of caspofungin and posaconazole in a murine model of disseminated Exophiala infection SO MEDICAL MYCOLOGY LA English DT Article; Proceedings Paper CT 45th Interscience Conference on Antimicrobial Agents and Chemotherapy CY DEC 16-19, 2005 CL Washington, DC DE phaeohyphomycosis; Exophiala; caspofungin; posaconazole; mouse ID CLINICALLY IMPORTANT MOLDS; IN-VITRO; DISSEMINATED PHEOHYPHOMYCOSIS; EPIDEMIOLOGY; THERAPY; PHARMACOKINETICS; VORICONAZOLE; JEANSELMEI; L-743,872; EMERGENCE AB Disseminated phaeohyphomycosis is an uncommon infection affecting immunocompetent and immunocompromised individuals in which response to older antifungal agents has been variable. We compared the effect of six days of therapy with caspofungin, posaconazole, and amphotericin B in parallel studies of survival and fungal burden in an immunocompromised mouse model of Exophiala infection. Mice immunocompromised with cyclophosphamide were treated for 6 days starting one day after initiation of infection. Treatment regimens included amphotericin 13, caspofungin, and posaconazole. In the survival studies, experimental animals were observed for 14 days. In the fungal burden tests the experimental animals were sacrificed 7 days after infection and brain and kidney burden determined. Treatment with any agent decreased mortality (P < 0.05), with 40%, 30%, and 80% observed survival of the animals treated with amphotericin 13, caspofungin, and posaconazole, respectively. Amphotericin B and posaconazole treatment resulted in a decrease in fungal burden compared to untreated controls (P < 0.05). No reduction in fungal burden was noted in the caspofungin group. All three antifungals evaluated improved survival of immunocompromised mice in this otherwise fatal disseminated phaeohyphomycosis. Amphotericin B and posaconazole reduced fungal burden. Posaconazole and caspofungin appear to have potential for use in treatment of this rare infection. C1 [Rivard, Robert G.; Mccall, Suzanne; Griffith, Matthew E.; Hawley, Joshua S.; Ressner, Roseanne A.; Borra, Himabindu; Moon, James E.; Beckius, Miriam L.; Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, Dept Med, Ft Sam Houston, TX 78234 USA. [Rivard, Robert G.; Mccall, Suzanne; Griffith, Matthew E.; Hawley, Joshua S.; Ressner, Roseanne A.; Borra, Himabindu; Moon, James E.; Beckius, Miriam L.; Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM duaiie.hospeiithal@amedd.army.mil RI Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 NR 24 TC 11 Z9 12 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1369-3786 J9 MED MYCOL JI Med. Mycol. PD DEC PY 2007 VL 45 IS 8 BP 685 EP 689 DI 10.1080/13693780701390157 PG 5 WC Infectious Diseases; Mycology; Veterinary Sciences SC Infectious Diseases; Mycology; Veterinary Sciences GA 249HR UT WOS:000252219400002 PM 17885951 ER PT J AU Heine, R Barker, D AF Heine, Richard Barker, Donald TI Simplified terrain identification and component fatigue damage estimation model for use in a health and usage monitoring system SO MICROELECTRONICS RELIABILITY LA English DT Article ID PROGNOSTICS AB Improved reliability of military ground vehicle systems is often in direct conflict with increased functionality and performance. Health and Usage Monitoring Systems or HUMS are being developed to address this issue. Traditionally, HUMS applications have been limited to high-cost equipment such as aircraft. In order to apply a HUMS to a relatively inexpensive military ground vehicle, simplified algorithms that derive terrain exposure from a basic set of sensors and estimate fatigue damage accumulated on components whose loading comes primarily from terrain have been developed. Various inputs and statistical parameters are evaluated for this model based on accuracy of terrain identification and quality of fatigue prediction on an example component. The generalized process and recommendations for application of this model to military ground vehicle systems are discussed. (c) 2007 Elsevier Ltd. All rights reserved. C1 Univ Maryland, Dept Mech Engn, Ctr Adv Life Cycle Engn CALCE, College Pk, MD 20742 USA. USA, Mat Syst Anal Activ, Logist Anal Div, Reliabil Branch, Aberdeen Proving Ground, MD 21005 USA. RP Barker, D (reprint author), Univ Maryland, Dept Mech Engn, Ctr Adv Life Cycle Engn CALCE, College Pk, MD 20742 USA. EM dbarker@calce.umd.edu NR 16 TC 3 Z9 3 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0026-2714 J9 MICROELECTRON RELIAB JI Microelectron. Reliab. PD DEC PY 2007 VL 47 IS 12 BP 1882 EP 1888 DI 10.1016/j.microrel.2007.02.017 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 238YH UT WOS:000251484000006 ER PT J AU Hansen, MMA AF Hansen, Major Michelle A. TI Preventing the emasculation of warfare: Halting the expansion of human rights law into armed conflict SO MILITARY LAW REVIEW LA English DT Article ID INTERNATIONAL HUMAN-RIGHTS; MILITARY OCCUPATION; WAR; TREATIES; CRIMES; FORCE; TIMES C1 USA, Washington, DC 20310 USA. RP Hansen, MMA (reprint author), USA, Washington, DC 20310 USA. NR 93 TC 5 Z9 5 U1 2 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2007 VL 194 BP 1 EP 65 PG 65 WC Law SC Government & Law GA 289WJ UT WOS:000255084300001 ER PT J AU Pflaum, MPD AF Pflaum, Major Patrick D. TI A matter of discipline and security: Prosecuting serious criminal offenses committed in US detention facilities abroad SO MILITARY LAW REVIEW LA English DT Article C1 USA, TJAGLCS, Criminal Law Dept, Charlottesville, VA USA. RP Pflaum, MPD (reprint author), USA, TJAGLCS, Criminal Law Dept, Charlottesville, VA USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2007 VL 194 BP 66 EP 131 PG 66 WC Law SC Government & Law GA 289WJ UT WOS:000255084300002 ER PT J AU DeWeese, MGS AF DeWeese, Major Geoffrey S. TI Hubris: The inside story of spin, scandal, and the selling of the Iraq War SO MILITARY LAW REVIEW LA English DT Book Review C1 [DeWeese, Major Geoffrey S.] USA, Washington, DC 20310 USA. RP DeWeese, MGS (reprint author), USA, Washington, DC 20310 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2007 VL 194 BP 170 EP 178 PG 9 WC Law SC Government & Law GA 289WJ UT WOS:000255084300004 ER PT J AU Jankunis, MJJ AF Jankunis, Major Joseph J. TI The shia revival: How conflicts within Islam will shape the future SO MILITARY LAW REVIEW LA English DT Book Review C1 [Jankunis, Major Joseph J.] USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Off Grad Course 56th, Charlottesville, VA USA. RP Jankunis, MJJ (reprint author), USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Off Grad Course 56th, Charlottesville, VA USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2007 VL 194 BP 179 EP 188 PG 10 WC Law SC Government & Law GA 289WJ UT WOS:000255084300005 ER PT J AU Chaffin, JG Mangelsdorff, AD Finstuen, K AF Chaffin, Jeffrey G. Mangelsdorff, A. David Finstuen, Kenn TI The development of a conceptual model for evaluating dental patient satisfaction SO MILITARY MEDICINE LA English DT Article ID CLIENT SATISFACTION; MILITARY MEDICINE; CARE; DOCTOR; COMMUNICATION; HEALTH; GAPS AB The purpose of this study was to identify levels and predictors of patient satisfaction and develop a conceptual model for dental patient satisfaction in military treatment facilities. Respondents completed 658,443 surveys during 17 fiscal quarters, beginning with the fourth quarter of 2000. The final data set contained 309,261 surveys, with no missing data. Principal component factor analysis was used for data reduction and hierarchical multiple linear regression to assess the predictive effects of the dependent variables on the two independent variables: (1) overall satisfaction with today's visit and (2) overall satisfaction with the clinic. On a 7-point, bipolar adjective rating scale, patients' mean score was 6.53 regarding satisfaction with visit, suggesting that patients are highly satisfied. Patients' beliefs about care received and environment of care were the most important satisfaction attributes. These findings are useful in educating providers about the relationship of consumer satisfaction with the interpersonal experience. C1 [Chaffin, Jeffrey G.] Off Surgeon Gen, Dept Army, Falls Church, VA 22041 USA. [Mangelsdorff, A. David; Finstuen, Kenn] Baylor Univ, Grad Program Hlthcare & Business Adm, USA, Ft Sam Houston, TX 78234 USA. RP Chaffin, JG (reprint author), US Army Dent Command, 2050 Worth Rd, Ft Sam Houston, TX 78234 USA. NR 20 TC 1 Z9 2 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2007 VL 172 IS 12 BP 1239 EP 1244 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 242RQ UT WOS:000251743700005 PM 18274021 ER PT J AU Roop, SA Niven, AS Calvin, BE Bader, J Zacher, LL AF Roop, Stuart A. Niven, Alexander S. Calvin, Bryce E. Bader, Julia Zacher, Lisa L. TI The prevalence and impact of respiratory symptoms in asthmatics and nonasthmatics during deployment SO MILITARY MEDICINE LA English DT Article ID GLOBAL BURDEN; YOUNG-ADULTS; US NAVY; UNDERDIAGNOSIS AB Objective: The purpose of this study was to compare the prevalence, severity, and impact of respiratory symptoms in asthmatics and nonasthmatics during Operation Enduring Freedom and Operation Iraqi Freedom. Methods: A survey was given to 1,250 active duty soldiers and Department of Defense contractors returning from Operation Enduring Freedom/Operation Iraqi Freedom. Subjects were asked about demographics, smoking habits, respiratory symptoms, and impact on job performance before and during deployment. Patients with a history of asthma were asked method of diagnosis, current symptoms, and asthma therapy. Results: A total of 1,193 subjects returned the completed questionnaire (95% response rate). Mean age of respondents was 38 11 years, 83% (n = 977) were male, and 31% (n = 375) were past or present smokers. Sixty-one subjects (5%) reported a previous diagnosis of asthma. Both asthmatics and nonasthmatics had increased respiratory symptoms of wheezing, cough, sputum production, chest pain/tightness, and allergy symptoms during deployment compared to predeployment (p < 0.05 for all). When compared to nonasthmatics, asthmatic subjects reported more wheezing, sputum production, and chest pain/tightness during deployment (p < 0.0001, 0.05, 0.05 respectively), had more difficulty with military duties (p < 0.05), and were more likely to seek medical attention and receive duty restrictions (p < 0.0001). Twenty-six percent (n = 16) of asthmatics reported poor baseline symptom control, and this group had significantly increased symptoms, functional limitations, and health care utilization when compared to asthmatics who were symptom-controlled at baseline. Conclusions: Respiratory symptoms were common among both asthmatics and nonasthmatics during deployment. Differences in symptoms and health care utilization in this group of asthmatics were primarily due to subjects with poor baseline control. C1 [Roop, Stuart A.; Niven, Alexander S.; Calvin, Bryce E.; Zacher, Lisa L.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Roop, Stuart A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Roop, SA (reprint author), William Beaumont Army Med Ctr, El Paso, TX 79920 USA. NR 23 TC 31 Z9 31 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2007 VL 172 IS 12 BP 1264 EP 1269 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 242RQ UT WOS:000251743700010 PM 18274026 ER PT J AU Slim, AM Roth, JE Duffy, B Boyd, SYN Rubal, BJ AF Slim, Ahmad M. Roth, Jason E. Duffy, Benjamin Boyd, Sheri Y. N. Rubal, Bernard J. TI The incidence of phlebitis with intravenous amiodarone at guideline dose recommendations SO MILITARY MEDICINE LA English DT Article ID ONSET ATRIAL-FIBRILLATION; OPEN-HEART-SURGERY; SINUS RHYTHM; PREVENTION; THROMBOPHLEBITIS; METAANALYSIS; MANAGEMENT; EFFICACY; TRIALS AB Postoperative atrial fibrillation following cardiothoracic surgery is common and frequently managed with intravenous (IV) amiodarone. Phlebitis is the most common complication with peripheral infusion of this agent. Current practice guidelines for peripheral IV administration of <2 mg/mL amiodarone were established to reduce the risk of phlebitis. The present study examines the incidence of phlebitis in a postoperative patient population given current dose recommendations. A total of 273 patient charts were reviewed. The incidence of phlebitis in patients given IV amiodarone (n = 36) was 13.9% (95% confidence interval, 2.6-25.2%; p = 0.001). Logistic regression analysis with backward elimination of other therapeutic risk factors suggests that the odds ratio for phlebitis using current dose regimens without IV filters is 19-fold greater than baseline risk in this population. Phlebitis remains a significant complication associated with peripheral infusion of amiodarone within recommended dosing limits. C1 [Slim, Ahmad M.; Roth, Jason E.; Duffy, Benjamin; Boyd, Sheri Y. N.; Rubal, Bernard J.] Brooke Army Med Ctr, Serv Cardiol, Ft Sam Houston, TX 78234 USA. RP Slim, AM (reprint author), Brooke Army Med Ctr, Serv Cardiol, Ft Sam Houston, TX 78234 USA. NR 24 TC 4 Z9 5 U1 3 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2007 VL 172 IS 12 BP 1279 EP 1283 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 242RQ UT WOS:000251743700013 PM 18274029 ER PT J AU Scanlan, BJ Tuft, B Elfrey, JE Smith, A Zhao, A Morimoto, M Chmielinska, JJ Tejero-Taldo, MI Mak, IT Weglicki, WB Shea-Donohue, T AF Scanlan, Bradford J. Tuft, Blaine Elfrey, Justin E. Smith, Allen Zhao, Aiping Morimoto, Motoko Chmielinska, Joanna J. Tejero-Taldo, Maria Isabel Mak, Iu Tong Weglicki, William B. Shea-Donohue, Terez TI Intestinal inflammation caused by magnesium deficiency alters basal and oxidative stress-induced intestinal function SO MOLECULAR AND CELLULAR BIOCHEMISTRY LA English DT Article DE hypomagnesemia; oxidative stress; neutrophil; inflammation; nitric oxide ID ISCHEMIA-REPERFUSION INJURY; BLOOD-CELL GLUTATHIONE; RAT SMALL-INTESTINE; MESENTERIC ISCHEMIA/REPERFUSION; MG-DEFICIENCY; INTENSIVE-CARE; RECRUITMENT; DYSFUNCTION; MODULATION; NEUTROPHIL AB The aim of this study was to determine the effect of magnesium deficiency on small intestinal morphology and function. Rats were assigned to 4 groups and placed on magnesium sufficient or deficient diet for 1 or 3 weeks. Infiltration of neutrophils and mucosal injury were assessed in stained sections of small intestine. Magnesium deficiency alone induced a significant increase in neutrophil infiltration and increased vascular ICAM-1 expression, in the absence of changes in mucosal injury or expression of proinflammatory mediators. Magnesium deficiency was associated with hyposecretory epithelial cell responses and vascular macromolecular leak in the small intestine and lung, which was attributed partly to reduced expression of NOS-3. To determine the effect of hypomagnesmia on the intestinal responses to a known oxidative stress, groups of rats were randomized to either sham operation or superior mesenteric artery occlusion for 10 (non-injurious) or 30 (injurious) minutes followed by a 1- or 4-hour reperfusion period. In response to mesenteric ischemia/reperfusion, deficient rats showed exaggerated PMN influx, but similar mucosal injury. Intestinal ischemia in sufficient animals induced vascular macromolecular leak in the small intestine and lung at 4 hours of reperfusion, with levels similar to those observed in untreated deficient rats. Acute magnesium repletion of deficient rats 24 h before surgery attenuated the exaggerated inflammation in deficient rats. These data show that magnesium deficiency induced a subclinical inflammation in the small intestine in the absence of mucosal injury, but with significant functional changes in local and remote organs and increased sensitivity to oxidative stress. C1 Univ Maryland, Sch Med, Mucosal Biol Res Ctr, Dept Med, Baltimore, MD 21201 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. USDA, Human Nutr Res Ctr, Nutr Requirements & Functions Lab, ARS, Beltsville, MD 20705 USA. George Washington Univ, Med Ctr, Dept Biochem & Mol Biol, Div Expt Med, Washington, DC 20037 USA. RP Shea-Donohue, T (reprint author), Univ Maryland, Sch Med, Mucosal Biol Res Ctr, Dept Med, Baltimore, MD 21201 USA. EM tdonohue@medicine.umaryland.edu FU NHLBI NIH HHS [HL-65718, R01-HL-62282]; NIAID NIH HHS [R01 AI049316, AI 49316] NR 37 TC 11 Z9 12 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0300-8177 J9 MOL CELL BIOCHEM JI Mol. Cell. Biochem. PD DEC PY 2007 VL 306 IS 1-2 BP 59 EP 69 DI 10.1007/s11010-007-9554-y PG 11 WC Cell Biology SC Cell Biology GA 222NT UT WOS:000250304900008 PM 17657590 ER PT J AU O'Malley, KG Camara, MD Banks, MA AF O'Malley, Kathleen G. Camara, Mark D. Banks, Michael A. TI Candidate loci reveal genetic differentiation between temporally divergent migratory runs of Chinook salmon (Oncorhynchus tshawytscha) SO MOLECULAR ECOLOGY LA English DT Article DE chinook salmon; Clock gene; genetic structure; Ots515NWFSC; run timing; spawning time ID GONADOTROPIN-RELEASING-HORMONE; PHOTOPERIODIC TIME MEASUREMENT; CROSS-SPECIES AMPLIFICATION; RAINBOW-TROUT; LIFE-HISTORY; POPULATION-STRUCTURE; MICROSATELLITE LOCI; DROSOPHILA HOMOLOG; PACIFIC SALMON; CLOCK GENES AB Local adaptation is a dynamic process driven by selection that can vary both in space and time. One important temporal adaptation for migratory animals is the time at which individuals return to breeding sites. Chinook salmon (Oncorhynchus tshawytscha) are excellent subjects for studying the genetic basis of temporal adaptation because their high seasonal homing fidelity promotes reproductive isolation leading to the formation of local populations across diverse environments. We tested for adaptive genetic differentiation between seasonal runs of Chinook salmon using two candidate loci; the circadian rhythm gene, OtsClock1b, and Ots515NWFSC, a microsatellite locus showing sequence identity to three salmonid genes central to reproductive development. We found significant evidence for two genetically distinct migratory runs in the Feather River, California (OtsClock1b: F-ST = 0.042, P = 0.02; Ots515NWFSC: F-ST = 0.058, P = 0.003). In contrast, the fall and threatened spring runs are genetically homogenous based on neutral microsatellite data (F-ST = -0.0002). Similarly, two temporally divergent migratory runs of Chinook salmon from New Zealand are genetically differentiated based on polymorphisms in the candidate loci (OtsClock1b: F-ST = 0.083, P-value = 0.001; Ots515NWFSC: F-ST = 0.095, P-value = 0.000). We used an individual-based assignment method to confirm that these recently diverged populations originated from a single source in California. Tests for selective neutrality indicate that OtsClock1b and Ots515NWFSC exhibit substantial departures from neutral expectations in both systems. The large F-ST estimates could therefore be the result of directional selection. Evidence presented here suggests that OtsClock1b and Ots515NWFSC may influence migration and spawning timing of Chinook salmon in these river systems. C1 Oregon State Univ, Hatfield Marine Sci Ctr, Dept Fisheries & Wildlife, Coastal Oregon Marine Expt Stn, Newport, OR 97365 USA. USA, USDA ARS, Newport, OR 97365 USA. RP O'Malley, KG (reprint author), Oregon State Univ, Hatfield Marine Sci Ctr, Dept Fisheries & Wildlife, Coastal Oregon Marine Expt Stn, 2030 SE Marine Sci Dr, Newport, OR 97365 USA. EM kathleen.omalley@oregonstate.edu NR 65 TC 46 Z9 46 U1 0 U2 21 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0962-1083 J9 MOL ECOL JI Mol. Ecol. PD DEC PY 2007 VL 16 IS 23 BP 4930 EP 4941 DI 10.1111/j.1365-294X.2007.03565.x PG 12 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 235AF UT WOS:000251205200007 PM 17971087 ER PT J AU Ricciardi, R Szabo, CM Poullos, AY AF Ricciardi, Richard Szabo, Christina M. Poullos, Amy Yribarren TI Sexuality and spinal cord injury SO NURSING CLINICS OF NORTH AMERICA LA English DT Article ID ERECTILE DYSFUNCTION; WOMEN; QUALITY; REHABILITATION; SATISFACTION; EJACULATION; ADOLESCENTS; INFERTILITY; CHILDREN; HEALTH AB In the United States, more than 250,000 people are living with spinal cord injury (SCI). SCI is most often the result of direct trauma to the spinal cord, but can also be associated with congenital or degenerative disease. These individuals experience physical and psychologic consequences that have a profound impact on their sexual health. Using a holistic, developmental, team approach to care, the nurse is well positioned to address the acute and long-term sexual rehabilitation needs of the SCI patient. By assisting SCI patients through the grieving process and promoting a positive, yet realistic, self-concept, nurses can mitigate potential problems in body image disturbances, decreased self-esteem, and gender-specific sexuality issues. C1 [Ricciardi, Richard] Walter Reed Army Med Ctr, Washington, DC 20012 USA. [Ricciardi, Richard] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Szabo, Christina M.] Virginia Commonwealth Univ Hlth Syst, Richmond, VA 23294 USA. RP Ricciardi, R (reprint author), Walter Reed Army Med Ctr, POB 59645,Walter Reed Stn, Washington, DC 20012 USA. EM Richard.Ricciardi@us.army.mil NR 45 TC 9 Z9 11 U1 2 U2 12 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0029-6465 J9 NURS CLIN N AM JI Nurs. Clin. North Am. PD DEC PY 2007 VL 42 IS 4 BP 675 EP + DI 10.1016/j.cnur.2007.08.005 PG 12 WC Nursing SC Nursing GA 241TX UT WOS:000251679800013 PM 17996763 ER PT J AU Bothwell, NE Shvidler, J Cable, BB AF Bothwell, Nici Eddy Shvidler, Joseph Cable, Benjamin B. TI Acute rise in methicillin-resistant Staphylococcus aureus infections in a coastal community SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 110th Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation CY SEP 17-20, 2006 CL Toronto, CANADA SP Amer Acad Otolaryngol Head & Neck Surg Fdn ID COLONIZATION AB OBJECTIVE: Describe the incidence of head and neck community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA) infections over a 5-year period at a coastal tertiary medical center. STUDY DESIGN: Retrospective chart review. SUBJECTS AND METHODS: All patients presenting to the otolaryngology service with cultures taken from head and neck infections between 1999 and 2004 were eligible for inclusion. Statistical analysis was used to determine significance of the changing incidence of isolated organisms over the study period. RESULTS: CA-MRSA infections rose from 21% to 64% over the 5-year period. The increasing trend in CA-MRSA infections reached statistical significance from 2003 to 2004. All CA-MRSA isolates were resistant to cefazolin and penicillin, but most were sensitive to clindamycin. CONCLUSIONS: Our data demonstrates a striking increase in the incidence of CA-MRSA. We have tailored our treatment of cutaneous head and neck infections to include empiric treatment for CA-MRSA using clindamycin. Awareness and monitoring of this trend will be important for all practitioners involved in the care of these patients. (c) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 Tripler Army Med Ctr, Tripler, HI USA. RP Bothwell, NE (reprint author), Reynolds Army Community Hosp, 3009 SW Wilson St, Ft Sill, OK 73503 USA. EM nici.eddy.bothwell@us.army.mil NR 13 TC 17 Z9 17 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD DEC PY 2007 VL 137 IS 6 BP 942 EP 946 DI 10.1016/j.otohns.2007.09.013 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 237OQ UT WOS:000251385100017 PM 18036425 ER PT J AU Dintaman, J Watson, C Fox, CJ Hoover, N Roberts, S Gillespie, DL AF Dintaman, J. Watson, C. Fox, C. J. Hoover, N. Roberts, S. Gillespie, D. L. TI Case of adolescent with Paget-Schroetter Syndrome and underlying thrombophilia due to an elevated lipoprotein (A) SO PEDIATRIC BLOOD & CANCER LA English DT Article ID VENOUS THROMBOEMBOLIC COMPLICATIONS; VEIN-THROMBOSIS; RISK-FACTOR; CHILDREN; CHILDHOOD; REGISTRY; THERAPY C1 Walter Reed Army Med Ctr, Vasc Surg Serv, Washington, DC 20307 USA. Natl Capital Consortium, Dept Pediat, Washington, DC USA. Uniformed Serv Univ Hlth Sci, Div Vasc Surg, Bethesda, MA USA. Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MA USA. RP Dintaman, J (reprint author), Walter Reed Army Med Ctr, Vasc Surg Serv, Bldg 2,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM jay.dintaman@na.amedd.army.mil NR 16 TC 3 Z9 3 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1545-5009 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD DEC PY 2007 VL 49 IS 7 BP 1036 EP 1038 DI 10.1002/pbc.20790 PG 3 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 224ZV UT WOS:000250487800037 PM 16496286 ER PT J AU Sule, SD Fadrowski, JJ Fivush, BA Gorman, G Furth, SL AF Sule, Sangeeta D. Fadrowski, Jeffrey J. Fivush, Barbara A. Gorman, Gregory Furth, Susan L. TI Reduced albumin levels and utilization of arteriovenous access in pediatric patients with systemic lupus erythematosus (SLE) SO PEDIATRIC NEPHROLOGY LA English DT Article DE systemic lupus erythematosus; pediatrics; dialysis; albumin; vascular access ID AMBULATORY PERITONEAL-DIALYSIS; STAGE RENAL-DISEASE; HEMODIALYSIS-PATIENTS; SINGLE-CENTER; CLASSIFICATION; CHILDHOOD; MORBIDITY; NEPHRITIS; OUTCOMES; ONSET AB Systemic lupus erythematosus (SLE) is an autoimmune disease that affects between five and ten thousand children in the USA. Kidney disease may progress to end-stage renal disease (ESRD) and subsequent need for dialysis therapy in a significant number of children with SLE. We performed a cross-sectional analysis comparing achievement of National Kidney Foundation/Kidney Disease Outcomes Quality Initiative clinical targets in pediatric patients with SLE maintained on hemodialysis (HD) to pediatric patients with other causes of ESRD. Ninety-seven unique SLE patients and two control groups-1,823 unique pediatric patients with other causes of ESRD and 694 pediatric patients with glomerulonephritis-were identified in the End Stage Renal Disease Clinical Performance Measures 2000-2004 Project Years. SLE patients were older, with a female and black race predominance compared with both control groups. Pediatric patients maintained on HD secondary to SLE were less likely to meet albumin targets and more likely to have vascular catheters than were pediatric patients on HD secondary to other causes. These findings may be associated with increased morbidity and mortality in pediatric patients with SLE maintained on HD and deserve further study. C1 Johns Hopkins Univ, Sch Med, Baltimore, MD USA. Natl Naval Med Ctr, Walter Reed Army Med Ctr, Bethesda, MD USA. RP Sule, SD (reprint author), 200 N Wolfe St,Suite 2126, Baltimore, MD 21205 USA. EM ssule@jhmi.edu FU NIDDK NIH HHS [K24 DK078737]; NIEHS NIH HHS [K23 ES016514] NR 35 TC 6 Z9 6 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0931-041X J9 PEDIATR NEPHROL JI Pediatr. Nephrol. PD DEC PY 2007 VL 22 IS 12 BP 2041 EP 2046 DI 10.1007/s00467-007-0591-2 PG 6 WC Pediatrics; Urology & Nephrology SC Pediatrics; Urology & Nephrology GA 228TO UT WOS:000250755700007 PM 17901989 ER PT J AU Killgore, WDS Kahn-Greene, ET Killgore, DB Kamimori, GH Balkin, TJ AF Killgore, William D. S. Kahn-Greene, Ellen T. Killgore, Desiree B. Kamimori, Gary H. Balkin, Thomas J. TI Effects of acute caffeine withdrawal on short category test performance in sleep-deprived individuals SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID DECISION-MAKING; DEPRIVATION; MOOD; RESTRICTION; SYMPTOMS; THINKING; TASKS AB Caffeine is a Popular stimulant often used to counter the effects of sleep loss and fatigue. Withdrawal from caffeine may produce mild declines in simple cognitive capacities Such as attention and concentration, but it is unclear whether more complex cognitive functions, such as abstract reasoning or concept formation, may be similarly affected. To assess the effect of acute caffeine withdrawal on executive functioning during sleep deprivation, 26 healthy volunteers were administered in double-blind form either repeated doses of caffeine or placebo over two nights of continuous wakefulness. The 108-item Short Category Test was administered after 56 hr. of total sleep deprivation (9 hr. post-caffeine administration). The caffeine group scored significantly more poorly, making approximately 57% more errors on the test than the placebo group. These findings suggest that acute caffeine withdrawal during prolonged sleep deprivation has an adverse effect on abstract reasoning and concept formation. C1 [Killgore, William D. S.; Kahn-Greene, Ellen T.; Killgore, Desiree B.; Kamimori, Gary H.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Killgore, WDS (reprint author), McLean Hosp, Cognit Neuroimaging Lab, Neuroimaging Ctr, 115 Mill St, Belmont, MA 02478 USA. EM killgore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 33 TC 3 Z9 3 U1 0 U2 4 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD DEC PY 2007 VL 105 IS 3 BP 1265 EP 1274 DI 10.2466/PMS.105.4.1265-1274 PN 2 PG 10 WC Psychology, Experimental SC Psychology GA 269RC UT WOS:000253665700030 PM 18380127 ER PT J AU Romero, NA Mattson, WD AF Romero, Nichols A. Mattson, William D. TI Density-functional calculation of the shock Hugoniot for diamond SO PHYSICAL REVIEW B LA English DT Article ID TOTAL-ENERGY CALCULATIONS; AB-INITIO CALCULATION; WAVE BASIS-SET; MOLECULAR-DYNAMICS; HIGH-PRESSURES; PHASE-DIAGRAM; BAND-GAPS; CARBON; SEMICONDUCTORS; STATE AB The principal Hugoniot of diamond is calculated using density-functional molecular dynamics. Using existing ab initio melt lines, diamond is predicted to melt on its Hugoniot in the range of 700-745 GPa. The shock compression of diamond into a high-density conducting liquid phase has an associated 13%-14% density increase across its coexistence region. Complete band gap closure before the onset of melting is not observed within these calculations. The importance of two simulation parameters necessary for obtaining quantitatively accurate predictions in the liquid carbon phase is identified: electronic temperature and supercell size. Our results expound upon existing laser-driven shock experiments and provide valuable equation of state data relevant to future high-pressure physics experiments. C1 [Romero, Nichols A.; Mattson, William D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Romero, NA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 45 TC 16 Z9 16 U1 1 U2 16 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD DEC PY 2007 VL 76 IS 21 AR 214113 DI 10.1103/PhysRevB.76.214113 PG 8 WC Physics, Condensed Matter SC Physics GA 246CW UT WOS:000251986100034 ER PT J AU Grimberg, BT Udomsangpetch, R Xainli, J McHenry, A Panichakul, T Sattabongkot, J Cui, L Bockarie, M Chitnis, C Adams, J Zimmerman, PA King, CL AF Grimberg, Brian T. Udomsangpetch, Rachanee Xainli, Jia McHenry, Amy Panichakul, Tasanee Sattabongkot, Jetsumon Cui, Liwang Bockarie, Moses Chitnis, Chetan Adams, John Zimmerman, Peter A. King, Christopher L. TI Plasmodium vivax invasion of human erythrocytes inhibited by antibodies directed against the Duffy binding protein SO PLOS MEDICINE LA English DT Article ID PAPUA-NEW-GUINEA; BLOOD-GROUP; IN-VITRO; CHEMOKINE RECEPTOR; MALARIA PARASITE; FALCIPARUM; KNOWLESI; ANTIGEN; DOMAIN; SPECIFICITY AB Background Plasmodium vivax invasion requires interaction between the human Duffy antigen on the surface of erythrocytes and the P. vivax Duffy binding protein (PvDBP) expressed by the parasite. Given that Duffy-negative individuals are resistant and that Duffy-negative heterozygotes show reduced susceptibility to blood-stage infection, we hypothesized that antibodies directed against region two of P. vivax Duffy binding protein (PvDBPII) would inhibit P. vivax invasion of human erythrocytes. Methods and Findings Using a recombinant region two of the P. vivax Duffy binding protein (rPvDBPII), polyclonal antibodies were generated from immunized rabbits and affinity purified from the pooled sera of 14 P. vivax-exposed Papua New Guineans. It was determined by ELISA and by flow cytometry, respectively, that both rabbit and human antibodies inhibited binding of rPvDBPII to the Duffy antigen N-terminal region and to Duffy-positive human erythrocytes. Additionally, using immunofluorescent microscopy, the antibodies were shown to attach to native PvDBP on the apical end of the P. vivax merozoite. In vitro invasion assays, using blood isolates from individuals in the Mae Sot district of Thailand, showed that addition of rabbit anti-PvDBPII Ab or serum ( antibodies against, or serum containing antibodies against, region two of the Plasmodium vivax Duffy binding protein) ( 1: 100) reduced the number of parasite invasions by up to 64%, while pooled PvDBPII antisera from P. vivax-exposed people reduced P. vivax invasion by up to 54%. Conclusions These results show, for what we believe to be the first time, that both rabbit and human antibodies directed against PvDBPII reduce invasion efficiency of wild P. vivax isolated from infected patients, and suggest that a PvDBP-based vaccine may reduce human blood-stage P. vivax infection. C1 [Grimberg, Brian T.; Xainli, Jia; Zimmerman, Peter A.; King, Christopher L.] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA. [Udomsangpetch, Rachanee; Panichakul, Tasanee] Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. [McHenry, Amy] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Cui, Liwang] Penn State Univ, Dept Entomol, University Pk, PA 16802 USA. [Bockarie, Moses] Papua New Guinea Inst Med Res, Entomol Unit, Goroka, Papua N Guinea. [Chitnis, Chetan] Int Ctr Genet Engn & Biotechnol, Malaria Grp, New Delhi, India. [Adams, John] Univ S Florida, Dept Global Hlth, Global Hlth Infect Dis Res Program, Tampa, FL USA. [King, Christopher L.] Vet Affairs Res Serv, Cleveland, OH USA. RP Zimmerman, PA (reprint author), Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA. EM peter.zimmerman@case.edu; christopher.king@case.edu RI Grimberg, Brian/I-1251-2013; Adams, John/G-1800-2015 OI Grimberg, Brian/0000-0002-6015-4912; Adams, John/0000-0003-3707-7979 FU FIC NIH HHS [1D43 TW007122]; NIAID NIH HHS [R01 AI064478-03, R01 AI046919, R01 AI052312, AI52312, AI46919, R01 AI064478, T32 AI007024, AI07024] NR 51 TC 97 Z9 99 U1 2 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1549-1277 J9 PLOS MED JI PLos Med. PD DEC PY 2007 VL 4 IS 12 BP 1940 EP 1948 AR e337 DI 10.1371/journal.pmed.0040337 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 244OG UT WOS:000251874600016 PM 18092885 ER PT J AU Libraty, DH Myint, KSA Murray, CK Gibbons, RV Mammen, MP Endy, TP Li, WJ Vaughn, DW Nisalak, A Kalayanarooj, S Hospenthal, DR Green, S Rothman, AL Ennis, FA AF Libraty, Daniel H. Myint, Khin S. A. Murray, Clinton K. Gibbons, Robert V. Mammen, P. Mammen Endy, Timothy P. Li, Wenjun Vaughn, David W. Nisalak, Ananda Kalayanarooj, Siripen Hospenthal, Duane R. Green, Sharone Rothman, Alan L. Ennis, Francis A. TI A Comparative Study of Leptospirosis and Dengue in Thai Children SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID OUTBREAK; ILLNESS AB Background: Leptospirosis is an emerging zoonosis that is often under-recognized in children and commonly confused with dengue in tropical settings. An enhanced ability to distinguish leptospirosis from dengue in children would guide clinicians and public health personnel in the appropriate use of limited healthcare resources. Methodology/Principal Findings: We conducted a prospective, hospital-based, study of children with acute febrile illnesses and dengue in Thailand. Among the children without dengue, we identified those with leptospirosis using anti-leptospira IgM and microscopic agglutination titers in paired acute and convalescent blood samples. We then performed a case-control comparison of symptoms, signs, and clinical laboratory values between children with leptospirosis and dengue. In a semi-rural region of Thailand, leptospirosis accounted for 19% of the non-dengue acute febrile illnesses among children presenting during the rainy season. None of the children with leptospirosis were correctly diagnosed at the time of hospital discharge, and one third (33%) were erroneously diagnosed as dengue or scrub typhus. A predictive model to distinguish pediatric leptospirosis from dengue was generated using three variables: the absolute neutrophil count, plasma albumin, and aspartate aminotransferase levels in the first 72 hours of illness. Conclusions/Significance: Unrecognized leptospirosis can be a significant cause of "dengue-like'' febrile illness in children. Increased awareness of pediatric leptospirosis, and an enhanced ability to discriminate between leptospirosis and dengue early in illness, will help guide the appropriate use of healthcare resources in often resource-limited settings. C1 [Libraty, Daniel H.; Green, Sharone; Rothman, Alan L.; Ennis, Francis A.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01605 USA. [Myint, Khin S. A.; Gibbons, Robert V.; Mammen, P. Mammen; Endy, Timothy P.; Vaughn, David W.; Nisalak, Ananda] US Army Med Component, Dept Virol, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Li, Wenjun] Univ Massachusetts, Sch Med, Dept Prevent & Behav Med, Worcester, MA USA. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Dept Pediat, Bangkok, Thailand. RP Libraty, DH (reprint author), Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01605 USA. EM daniel.libraty@umassmed.edu RI Valle, Ruben/A-7512-2013; Li, Wenjun/F-5634-2015 OI Li, Wenjun/0000-0001-5335-7386 FU NIH/NIAID [P01 AI34533]; U.S. Army Medical Research and Materiel Command FX This work was supported by NIH/NIAID grant P01 AI34533 and the U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD, USA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 23 TC 21 Z9 24 U1 0 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2735 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD DEC PY 2007 VL 1 IS 3 AR e111 DI 10.1371/journal.pntd.0000111 PG 7 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 383XK UT WOS:000261707500009 PM 18160980 ER PT J AU Ciezak, JA Jenkins, TA Liu, ZX AF Ciezak, Jennifer A. Jenkins, Timothy A. Liu, Zhenxian TI Evidence for a high-pressure phase transition of epsilon-2,4,6,8,10,12-hexanitrohexaazaisowtirtzitane (CL-20) using vibrational spectroscopy SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE CL-20; diamond anvil cell; high pressure; HNIW; vibrational spectroscopy ID TRANSFORM RAMAN-SPECTROSCOPY; ENERGETIC MATERIALS; PROPELLANT FORMULATIONS; THERMAL-DECOMPOSITION; AB-INITIO; HEXANITROHEXAAZAISOWURTZITANE; RDX; POLYMORPHS; HMX; STABILITY AB The high-pressure response of epsilon-2,4,6,8,10,12-hexanitrohexaazaisowurtizane (CL-20) has been examined to 27 GPa in diamond anvil cells using vibrational spectroscopy. The results reveal evidence of an epsilon -> gamma pressure-induced phase transition between 4.1 and 6.4 GPa and suggest the existence of a gamma -> zeta transition near 18.7 GPa. Several Raman and infrared frequencies were found to decrease in intensity as the phase boundaries are approached. An anomalous intensity increase was noted in the C-N-C infrared mode that is believed to result from an increase in the Raman cross-section due to a stronger interlayer coupling under pressure. C1 [Ciezak, Jennifer A.] USA, Res Lab, BWCD PSB WMRD, Aberdeen Proving Ground, MD 21005 USA. [Ciezak, Jennifer A.; Jenkins, Timothy A.; Liu, Zhenxian] Carnegie Inst Washington, Geophys Lab, Washington, DC 20015 USA. RP Ciezak, JA (reprint author), USA, Res Lab, BWCD PSB WMRD, Aberdeen Proving Ground, MD 21005 USA. EM jciezak@arl.army.mil NR 27 TC 17 Z9 17 U1 7 U2 19 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD DEC PY 2007 VL 32 IS 6 BP 472 EP 477 DI 10.1002/prep.200700209 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 253RS UT WOS:000252535900007 ER PT J AU Babushok, VI DeLucia, FC Dagdigian, PJ Gottfried, JL Munson, CA Nusea, MJ Miziolek, AW AF Babushok, V. I. DeLucia, F. C., Jr. Dagdigian, P. J. Gottfried, J. L. Munson, C. A. Nusea, M. J. Miziolek, A. W. TI Kinetic modeling study of the laser-induced plasma plume of cyclotrimethylenetrinitramine (RDX) SO SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY LA English DT Article; Proceedings Paper CT 4th International Conference on Laser-Induced Breakdown Spectroscopy (LIBS 2006) CY SEP 04-08, 2006 CL Montreal, CANADA SP Canada Ind Mat Inst, Natl Res Council DE laser-induced breakdown spectroscopy; laser plasma; kinetic model; RDX; explosive ID INDUCED BREAKDOWN SPECTROSCOPY; CROSS-SECTIONS; ATOMIC OXYGEN; METALLIC LEAD; CARBON-FILMS; DEPOSITION; COMBUSTION; DISSOCIATION; NITROGEN; C-2 AB A kinetic model of a laser-induced breakdown spectroscopy (LIBS) plume of cyclotrimethylenetrinitramine (RDX) was developed for the analysis of processes responsible for the LIBS signature of explosives. Air and argon were considered as buffer gases. The model includes a set of processes involving ion chemistry, as well as excitation, ionization, and other processes affecting neutral and ion species. Modeling results show that the overall reaction process can be considered a two-stage process. The first stage corresponds to a fast approach to a quasi-stationary state, while the second stage corresponds to the change of quasi-stationary species concentrations due to the change in temperature. As a result of the two-stage process, the initial mechanism of explosive decomposition is not important in determining its signature in the LIBS measurement time window (1-30 mu s). The main processes responsible for generation of excited states for the LIBS emission are electron-excitation impact processes. A mechanism for the appearance of a double peak of the C(2) species concentration in the RDX plasma plume was suggested. Double-peak behavior of the C2 species was previously experimentally observed during laser ablation of graphite. Published by Elsevier B.V. C1 [Babushok, V. I.] NIST, Gaithersburg, MD 20899 USA. [DeLucia, F. C., Jr.; Gottfried, J. L.; Munson, C. A.; Nusea, M. J.; Miziolek, A. W.] USA, Ballist Res Lab, AMSRL WM BD, Aberdeen Proving Ground, MD 21005 USA. [Dagdigian, P. J.] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA. RP Babushok, VI (reprint author), NIST, Bldg 221,Room A111, Gaithersburg, MD 20899 USA. EM babushok@nist.gov RI Gottfried, Jennifer/G-6333-2010; Munson, Chase/H-1667-2012; De Lucia, Frank/D-5630-2012 NR 35 TC 48 Z9 48 U1 2 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0584-8547 J9 SPECTROCHIM ACTA B JI Spectroc. Acta Pt. B-Atom. Spectr. PD DEC PY 2007 VL 62 IS 12 BP 1321 EP 1328 DI 10.1016/j.sab.2007.10.029 PG 8 WC Spectroscopy SC Spectroscopy GA 249CM UT WOS:000252204500005 ER PT J AU De Lucia, FC Gottfried, JL Munson, CA Miziolek, AW AF De Lucia, Frank C., Jr. Gottfried, Jennifer L. Munson, Chase A. Miziolek, Andrzej W. TI Double pulse laser-induced breakdown spectroscopy of explosives: Initial study towards improved discrimination SO SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY LA English DT Article; Proceedings Paper CT 4th International Conference on Laser-Induced Breakdown Spectroscopy (LIBS 2006) CY SEP 04-08, 2006 CL Montreal, CANADA SP Canada Ind Mat Inst, Natl Res Council DE laser-induced breakdown spectroscopy (LIBS); double pulse; explosives; principal components analysis; ROC curves ID LIBS; ENHANCEMENT; ABLATION; EMISSION AB Detecting trace explosive residues at standoff distances in real-time is a difficult problem. One method ideally suited for real-time standoff detection is laser-induced breakdown spectroscopy (LIBS). However, atmospheric oxygen and nitrogen contributes to the LIBS signal from the oxygen- and nitrogen-containing explosive compounds, complicating the discrimination of explosives from other organic materials. While bathing the sample in an inert gas will remove atmospheric oxygen and nitrogen interference, it cannot practically be applied for standoff LIBS. Alternatively, we have investigated the potential of double pulse LIBS to improve the discrimination of explosives by diminishing the contribution of atmospheric oxygen and nitrogen to the LIBS signal. These initial studies compare the close-contact (< 1 m) LIBS spectra of explosives using single pulse LIBS in argon with double pulse LIBS in atmosphere. We have demonstrated improved discrimination of an explosive and an organic interferent using double pulse LIBS to reduce the air entrained in the analytical plasma. Published by Elsevier B.V. C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.; Munson, Chase A.; Miziolek, Andrzej W.] USA, Ballist Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. RP De Lucia, FC (reprint author), USA, Ballist Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. EM fdelucia@arl.army.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012; Munson, Chase/H-1667-2012 NR 18 TC 70 Z9 70 U1 3 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0584-8547 J9 SPECTROCHIM ACTA B JI Spectroc. Acta Pt. B-Atom. Spectr. PD DEC PY 2007 VL 62 IS 12 SI SI BP 1399 EP 1404 DI 10.1016/j.sab.2007.10.036 PG 6 WC Spectroscopy SC Spectroscopy GA 249CM UT WOS:000252204500014 ER PT J AU Gottfried, JL De Lucia, FC Munson, CA Miziolek, AW AF Gottfried, Jennifer L. De Lucia, Frank C., Jr. Munson, Chase A. Miziolek, Andrzej W. TI Double-pulse standoff laser-induced breakdown spectroscopy for versatile hazardous materials detection SO SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY LA English DT Article; Proceedings Paper CT 4th International Conference on Laser-Induced Breakdown Spectroscopy (LIBS 2006) CY SEP 04-08, 2006 CL Montreal, CANADA SP Canada Ind Mat Inst, Natl Res Council DE LIBS; double pulse; standoff detection; energetic material ID CONFIGURATION; SINGLE; LIBS; DISCRIMINATION; IDENTIFICATION; ENHANCEMENT; BACTERIA; SENSOR; SPORES; AIR AB We have developed a double-pulse standoff laser-induced breakdown spectroscopy (ST-LIBS) system capable of detecting a variety of hazardous materials at tens of meters. The use of a double-pulse laser improves the sensitivity and selectivity of ST-LIBS, especially for the detection of energetic materials. In addition to various metallic and plastic materials, the system has been used to detect bulk explosives RDX and Composition-B, explosive residues, biological species such as the anthrax surrogate Bacillus subtilis, and chemical warfare simulants at 20 m. We have also demonstrated the discrimination of explosive residues from various interferents on an aluminum substrate. Published by Elsevier B.V. C1 [Gottfried, Jennifer L.; De Lucia, Frank C., Jr.; Munson, Chase A.; Miziolek, Andrzej W.] USA, Ballist Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. RP Gottfried, JL (reprint author), USA, Ballist Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.gottfried@arl.army.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012; Munson, Chase/H-1667-2012 NR 25 TC 103 Z9 106 U1 3 U2 27 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0584-8547 J9 SPECTROCHIM ACTA B JI Spectroc. Acta Pt. B-Atom. Spectr. PD DEC PY 2007 VL 62 IS 12 SI SI BP 1405 EP 1411 DI 10.1016/j.sab.2007.10.039 PG 7 WC Spectroscopy SC Spectroscopy GA 249CM UT WOS:000252204500015 ER PT J AU McMillan, NJ Harmon, RS De Lucia, FC Miziolek, AM AF McMillan, Nancy J. Harmon, Russell S. De Lucia, Frank C. Miziolek, Andrzej M. TI Laser-induced breakdown spectroscopy analysis of minerals: Carbonates and silicates SO SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY LA English DT Article; Proceedings Paper CT 4th International Conference on Laser-Induced Breakdown Spectroscopy (LIBS 2006) CY SEP 04-08, 2006 CL Montreal, CANADA SP Canada Ind Mat Inst, Natl Res Council DE laser-induced breakdown spectroscopy; LIBS; mineral; carbonate; silicate ID FIELD; LIBS AB Laser-induced breakdown spectroscopy (LIBS) provides an alternative chemical analytical technique that obviates the issues of sample preparation and sample destruction common to most laboratory-based analytical methods. This contribution explores the capability of LIBS analysis to identify carbonate and silicate minerals rapidly and accurately. Fifty-two mineral samples (18 carbonates, 9 pyroxenes and pyroxenoids, 6 amphiboles, 8 phyllosilicates, and 11 feldspars) were analyzed by LIBS. Two composite broadband spectra (averages of 10 shots each) were calculated for each sample to produce two databases each containing the composite LIBS spectra for the same 52 mineral samples. By using correlation coefficients resulting from the regression of the intensities of pairs of LIBS spectra, all 52 minerals were correctly identified in the database. If the LIBS spectra of each sample were compared to a database containing the other 51 minerals, 65% were identified as a mineral of similar composition from the same mineral family. The remaining minerals were misidentified for two reasons: 1) the mineral had high concentrations of an element not present in the database; and 2) the mineral was identified as a mineral with similar elemental composition from a different family. For instance, the Ca-Mg carbonate dolomite was misidentified as the Ca-Mg silicate diopside. This pilot study suggests that LIBS has promise in mineral identification and in situ analysis of minerals that record geological processes. (c) 2007 Elsevier B.V. All rights reserved. C1 [McMillan, Nancy J.] New Mexico State Univ, Dept Geol Sci, Las Cruces, NM 88003 USA. [Harmon, Russell S.] USA, Res Off, Environm Sci Div, Res Triangle Pk, NC 27709 USA. [De Lucia, Frank C.; Miziolek, Andrzej M.] USA, Ballist Res Lab, Weap & Mat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP McMillan, NJ (reprint author), New Mexico State Univ, Dept Geol Sci, Box 30001,MSC 3AB, Las Cruces, NM 88003 USA. EM nmcmilla@nmsu.edu RI De Lucia, Frank/D-5630-2012 NR 9 TC 46 Z9 47 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0584-8547 J9 SPECTROCHIM ACTA B JI Spectroc. Acta Pt. B-Atom. Spectr. PD DEC PY 2007 VL 62 IS 12 SI SI BP 1528 EP 1536 DI 10.1016/j.sab.2007.10.037 PG 9 WC Spectroscopy SC Spectroscopy GA 249CM UT WOS:000252204500030 ER PT J AU Salerno, SM Faestel, PM Mulligan, T Rosenblum, MJ AF Salerno, Stephen M. Faestel, Paul M. Mulligan, Timothy Rosenblum, Michael J. TI Disruptions and satisfaction in internal medicine resident continuity clinic differ between inpatient and outpatient rotations SO TEACHING AND LEARNING IN MEDICINE LA English DT Article ID HOSPITALISTS; EXPERIENCE; PATIENT AB Background: Little is known about whether assignment to simultaneous inpatient and outpatient clinical duties causes disruptions during internal medicine resident continuity clinic and impacts trainee satisfaction. Purpose: Our purpose was to determine whether dual inpatient and continuity clinic responsibilities impact resident stress and document the number type, and immediacy of interruptions in continuity clinics. Methods: Methods included a prospective 2-residency survey of 70 internal medicine residents performing 240 half-day continuity clinic sessions. Results: More than half (52%) of trainees on inpatient rotations felt pressured to return to their ward duties. Half (50%) of residents thought clinic increased work hours, and the majority (70%) did not think continuity clinic detracted from their education on inpatient or elective rotations. Disturbances were more likely to occur on inpatient rotations (odds ratio 4.52, 95% confidence interval = 2.29-8.92) than on outpatient rotations. The time required to address an interruption was 3.9 +/- 4.51 min. Residents thought many (46%) problems addressed during clinic could have waited until clinic completion. Conclusions: Residents on inpatient rotations who were commonly interrupted in clinic felt pressured to return to ward duties and unable to focus on their clinic patients. Internal medicine faculty should modify curriculum to minimize the interference of other duties in resident clinics. C1 Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. Tufts Univ, Sch Med, Dept Internal Med, Springfield, MA 01199 USA. RP Salerno, SM (reprint author), Tripler Army Med Ctr, Dept Med MCHK DM, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM stephen.salerno@us.army.mil NR 13 TC 7 Z9 7 U1 1 U2 2 PU LAWRENCE ERLBAUM ASSOC INC PI MAHWAH PA 10 INDUSTRIAL AVE, MAHWAH, NJ 07430-2262 USA SN 1040-1334 J9 TEACH LEARN MED JI Teach. Learn. Med. PD WIN PY 2007 VL 19 IS 1 BP 30 EP 34 DI 10.1207/s15328015tlm1901_6 PG 5 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA 139MV UT WOS:000244437000005 PM 17330996 ER PT J AU Harper, SB Dertinger, SD Bishop, ME Lynch, AM Lorenzo, M Saylor, M MacGregor, JT AF Harper, Susan B. Dertinger, Stephen D. Bishop, Michelle E. Lynch, Anthony M. Lorenzo, Mari Saylor, Michelle MacGregor, James T. TI Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog SO TOXICOLOGICAL SCIENCES LA English DT Article ID CYTOGENETIC DAMAGE; ERYTHROCYTES; ASSAY; FREQUENCIES; RODENT; RAT AB Erythrocyte-based micronucleus tests have traditionally analyzed bone marrow because splenic filtration in most species removes micronucleated cells from peripheral blood. We have evaluated a flow cytometric method for monitoring micronucleated reticulocyte frequencies (%MN-RET) in the peripheral blood of beagle dogs treated with cyclophosphamide (CP) and have found that analysis of micronucleated reticulocytes (MN-RETs) in peripheral blood is a suitable surrogate for bone marrow analysis. The three-color flow cytometric method uses anti-CD71 labeling to identify reticulocytes and Plasmodium berghei-containing erythrocytes as a calibration standard. The spontaneous %MN-RET determined by flow cytometry was 0.31 +/- 0.09% (n = 22) for peripheral blood, compared with 0.38 +/- 0.13% (SD, n = 12) for bone marrow, and 0.27 +/- 0.08% (n = 12) for peripheral blood by microscopic scoring with acridine orange staining. The kinetics of appearance and disappearance of MN-RETs in blood were determined by collecting daily samples after iv treatment with CP. The maximum frequency occurred 48 h after dosing. Frequencies of MN-RETs in peripheral blood at steady state following daily CP treatment were 55-68% of corresponding bone marrow values assessed by microscopy and 55-112% as assessed by flow cytometry. This difference is presumably due to splenic removal, which appears slightly less stringent than that previously reported for CP-treated Sprague-Dawley rats. Responses in bone marrow and peripheral blood were highly correlated and similar to or greater than those reported in mice and rats at equitoxic doses. C1 Toxicol Consulting Serv, Arnold, MD 21012 USA. US FDA, Natl Ctr Toxicol Res, Rockville, MD 20857 USA. Johns Hopkins Univ, Baltimore, MD 21218 USA. Dept Vet Affairs, Washington, DC 20422 USA. Litron Lab, Rochester, NY 14623 USA. GlaxoSmithKline Res & Dev Ltd, Ware SG12 0DP, Herts, England. US FDA, Ctr Food Safety & Appl Nutr, Laurel, MD 20708 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Harper, SB (reprint author), Toxicol Consulting Serv, Arnold, MD 21012 USA. NR 34 TC 16 Z9 18 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 J9 TOXICOL SCI JI Toxicol. Sci. PD DEC PY 2007 VL 100 IS 2 BP 406 EP 414 DI 10.1093/toxsci/kfm241 PG 9 WC Toxicology SC Toxicology GA 232RU UT WOS:000251037800009 PM 17872896 ER PT J AU Lim, PLK Tan, W Latchoumycandane, C Mok, WC Khoo, YM Lee, HS Sattabongkot, J Beerheide, W Lim, SG Tan, TMC Boelsterli, UA AF Lim, Priscilla L. K. Tan, Weiqi Latchoumycandane, Calivarathan Mok, Wei Chuen Khoo, Yok Moi Lee, How Sung Sattabongkot, Jetsumon Beerheide, Walter Lim, Seng Gee Tan, Theresa M. C. Boelsterli, Urs A. TI Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04 SO TOXICOLOGY IN VITRO LA English DT Article DE drug-metabolizing enzymes; drug transporters; immortalized human hepatocytes; drug toxicity in vitro ID MITOCHONDRIAL PERMEABILITY TRANSITION; MESSENGER-RNA EXPRESSION; CELL-LINES; HUMAN-LIVER; CYTOCHROME-P450 EXPRESSION; TRANSCRIPTION FACTORS; CYP3A4 EXPRESSION; GENE-EXPRESSION; DICLOFENAC; INDUCTION AB In toxicological research, immortalized human hepatocytes provide a useful alternative to primary hepatocytes because interindividual variability in the expression of drug-metabolizing enzymes and drug transporters can largely be eliminated. However, it is essential that the cell line retain the original phenotype. The purpose of this study was to characterize a novel spontaneously immortalized human hepatocyte cell line, HC-04, with respect to the transcript and functional protein expression profile for the major drug-metabolizing enzymes and transmembrane transporters. HC-04 cells retained hepatocyte-specific function including albumin production and ornithine transcarbamoylase and glucose-6-phosphatase activity. Most of the major CYP forms were expressed at basal levels and responsive to inducing agents. In particular, CYP3A4 was expressed abundantly, and HC-04 cells were able to metabolize the CYP3A4 probe, midaz-olam, at a rate similar to primary human hepatocytes. Furthermore, the major human sulfotransferase and UDP-glucuronosyltransferase forms, as well as members of the ABC and SLC transporter superfamilies, nuclear receptors, and hepatic transcription factors were also expressed. HC-04 cells readily responded to standard hepatotoxicants that are dependent on CYP-mediated bioactivation, while another, tumor-derived cell line remained refractory to the drug challenge. Collectively, HC-04 cells provide a reliable, stable, and reproducible model for biomechanistic studies in drug toxicology. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Lim, Priscilla L. K.; Latchoumycandane, Calivarathan; Khoo, Yok Moi; Lee, How Sung; Boelsterli, Urs A.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117548, Singapore. [Tan, Weiqi; Tan, Theresa M. C.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117548, Singapore. [Mok, Wei Chuen; Lim, Seng Gee] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117548, Singapore. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Beerheide, Walter] Siam Life Sci Ltd, Bangkok 10500, Thailand. [Boelsterli, Urs A.] Natl Univ Singapore, Fac Sci, Dept Pharm, Singapore 117548, Singapore. RP Boelsterli, UA (reprint author), Univ Connecticut, Sch Pharm, Dept Pharmaceut Sci, Storrs, CT 06269 USA. EM urs.boelsterli@uconn.edu OI Tan, Theresa/0000-0003-1228-9449 NR 56 TC 24 Z9 25 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD DEC PY 2007 VL 21 IS 8 BP 1390 EP 1401 DI 10.1016/j.tiv.2007.05.003 PG 12 WC Toxicology SC Toxicology GA 239ZZ UT WOS:000251558100005 PM 17590308 ER PT J AU Rosner, IL Ravindranath, L Furusato, B Chen, YM Gao, CL Cullen, J Sesterhenn, IA McLeod, DG Srivastava, S Petrovics, G AF Rosner, Inger L. Ravindranath, Lakshmi Furusato, Bungo Chen, Yongmei Gao, Chunling Cullen, Jennifer Sesterhenn, Isabell A. McLeod, David G. Srivastava, Shiv Petrovics, Gyorgy TI Higher tumor to benign ratio of the androgen receptor mRNA expression associates with prostate cancer progression after radical prostatectomy SO UROLOGY LA English DT Article ID SAMPLING METHODS; STAGE T1C; SPECIMENS; GENE; P53; OVEREXPRESSION; FEATURES; TISSUES AB OBJECTIVES Alteration's of androgen receptor (AR) functions caused by overexpression, amplification, or mutation have been described in a significant Subset of advanced prostate cancer (CaP). Because AR mutations or amplification are rare in early stage CaP, we hypothesized that altered AR expression in prostate tumor cells may provide a prognostic indicator of disease progression. METHODS RNA from laser capture microdissected (LCM) tumor and benign epithelial cells from radical prostatectomy specimens of 115 hormone-naive patients were studied. Expression of AR and GAPDH genes were measured by duplex quantitative real-time polymerase chain reaction (RT-PCR) in 230 specimens. A ratio of the expression of AR gene, normalized to GAPDH gene expression in the same specimens, was compared in tumor and benign epithelial cells (tumor-to-benign ratio) and correlated with clinicopathologic features. RESULTS Paired t test analysis revealed a 62% lower AR expression in tumor tissue compared with benign tissue (P = 0.0005). However, multivariate Cox proportional hazards regression analysis of time to PSA recurrence revealed that higher tumor cell associated AR expression (continuous, log-transformed), significantly increases odds of prostate-specific antigen (PSA) recurrence (P = 0.0139) when controlling for age at surgery, race, time from diagnosis to surgery, risk stratification, pathologic T stage, Gleason sum, and margin status. CONCLUSIONS Quantitative determination of AR gene expression levels in prostate epithelial cells may be useful for predicting PSA recurrence. This study Supports the accumulating data suggesting that gain of AR function may contribute to CaP progression. C1 [Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. Uniformed Serv Univ Hlth Sci, Unites States Mil Canc Inst, Rockville, MD 20852 USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. Armed Forces Inst Pathol, Dept Genitourinary Med, Washington, DC 20306 USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. EM ssrivastava@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 NR 25 TC 19 Z9 19 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD DEC PY 2007 VL 70 IS 6 AR 1225 DI 10.1016/j.urology.2007.09.010 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 263CE UT WOS:000253194400056 PM 18158066 ER PT J AU Guan, J Wang, XH Smith, K Ager, A Gettayacamin, M Kyle, DE Milhous, WK Kozar, MP Magill, AJ Lin, AJ AF Guan, Jian Wang, Xihong Smith, Kirsten Ager, Arba Gettayacamin, Montip Kyle, Dennis E. Milhous, Wilbur K. Kozar, Michael P. Magill, Alan J. Lin, Ai J. TI Malaria causal prophylactic activity of imidazolidinedione derivatives SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID TROPHOZOITE-INDUCED INFECTIONS; PLASMODIUM-FALCIPARUM MALARIA; ANTIMALARIAL-ACTIVITIES; TAFENOQUINE; PRIMAQUINE; MEFLOQUINE; CYNOMOLGI; EFFICACY; TRIAZINE; INVITRO AB A series of acid-stable carboxamide derivatives of 2-guanidinoimidazolidinedione (5a-c and 6a-c) were prepared as potential malaria prophylactic and radical cure agents. The new compounds showed moderate to good causal prophylactic activity in mice infected with Plasmodium yoelii sporozoites. Three compounds were further tested for causal prophylactic activity in Rhesus monkeys infected with Plasmodium cynomolgi sporozoites, and all showed a delay in patency from 13 to 40 days at 30 mg/kg/day x 3 days by IM dosing. Two out of four compounds tested for radical curative activity in Rhesus showed cure at 30 mg/kg/day x 3 days. The other two compounds showed delay in relapse from 16 to 68 days. Conversion of new carboxamides (5 and 6) to s-triazine derivatives (7) was demonstrated in mouse and human microsomal preparations and in rat plasma. The results suggest the metabolites, s-triazine derivatives 7, may be the active species of the new carboxamides 5a-c and 6a-c prepared in this study. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. Univ Miami, Miami, FL 33177 USA. USAMC, AFRIMS, Bangkok, Thailand. Univ S Florida, Tampa, FL 33612 USA. RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM ai.lin@na.amedd.anny.mil RI Kozar, Michael/A-9155-2011 NR 22 TC 18 Z9 18 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD NOV 29 PY 2007 VL 50 IS 24 BP 6226 EP 6231 DI 10.1021/jm7009815 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 234RR UT WOS:000251181900038 PM 17967003 ER PT J AU Wagner, GW Procell, LR Munavalli, S AF Wagner, George W. Procell, Lawrence R. Munavalli, Shekar TI (27)AI, Ti-47,Ti-49, P-31, and C-13 MAS NMR study of VX, GD, and HD reactions with nanosize Al2O3, conventional Al2O3 and TiO2, and aluminum and titanium metal SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID AGENTS AB Reactions of VX, GD, and HD with Al2O3, TiO2 (anatase and rutile), aluminum, and titanium metal powders have been studied by Al-27, Ti-47,Ti-49, P-31, and C-13 MAS NMR. VX, GD, and HD hydrolyze on both nanosize and conventional Al2O3. A significant droplet size effect on the reaction kinetics is observed. For VX and GD, Al-27 and P-31 MAS NMR detect the formation of aluminum phosphonate complexes. Similarly, GD hydrolysis on TiO2 yields titanium phosphonate species as detected by IT MAS NMR. Attempts at obtaining Ti-47,Ti-49 NMR spectra of these species and those of titanium phosphonate model compounds at 14 T were marginally successful. Ti-47,Ti-49 NMR spectra were obtainable for anatase and titanium metal; thus, severe second-order quadrupolar linebroadening is suspected for the titanium phosphonate complexes. Ti-47,Ti-49 NMR spectra obtained for anatase at high magnetic field (17.5 and 21 T) showed anticipated improvement in peak width and resolution. GD reacted with aluminum and titanium powder in the presence of water results in acid-dissolution of the metals and the formation of their respective metal phosphonates. C1 US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. GEO CENTERS Inc, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. RP Wagner, GW (reprint author), SAIC, Gunpowder Branch, PO Box 68, Aberdeen Proving Ground, MD 21010 USA. EM george.wagner@us.army.mil NR 20 TC 42 Z9 43 U1 1 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 29 PY 2007 VL 111 IS 47 BP 17564 EP 17569 DI 10.1021/jp074511k PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 234DO UT WOS:000251141100018 ER PT J AU Nepal, N Bedair, SM El-Masry, NA Lee, DS Steckl, AJ Zavada, JM AF Nepal, N. Bedair, S. M. El-Masry, N. A. Lee, D. S. Steckl, A. J. Zavada, J. M. TI Correlation between compositional fluctuation and magnetic properties of Tm-doped AlGaN alloys SO APPLIED PHYSICS LETTERS LA English DT Article ID BLUE EMISSION; GAN; SEMICONDUCTORS; TRANSITIONS; LINEWIDTHS; ALXGA1-XN AB The magnetic properties of Tm-doped Al(x)Ga(1-x)N (0 <= x <= 1) alloys grown by solid-source molecular beam epitaxy were studied by hysteresis measurements and shown to exhibit ferromagnetic behavior at room temperature. The measured magnetization was strongly dependent on the Al content and reached a maximum for x=0.62. Previously reported photoluminescence measurements on these films yielded a blue emission at 465 nm with peak intensity at the same Al content. Both magnetic and optical properties are directly correlated with the alloy compositional fluctuation found in undoped Al(x)Ga(1-x)N alloys. (c) 2007 American Institute of Physics. C1 N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. Univ Cincinnati, Nanoelect Lab, Cincinnati, OH 45221 USA. USA, Res Off, Durham, NC 27709 USA. RP Nepal, N (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM elmasry@ncsu.edu OI Steckl, Andrew/0000-0002-1868-4442 NR 25 TC 13 Z9 14 U1 0 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 26 PY 2007 VL 91 IS 22 AR 222503 DI 10.1063/1.2817741 PG 3 WC Physics, Applied SC Physics GA 236SV UT WOS:000251324600053 ER PT J AU Smith, TC Zamorski, M Smith, B Riddle, JR LeardMann, CA Wells, TS Engel, CC Hoge, CW Adkins, J Blaze, D AF Smith, Tyler C. Zamorski, Mark Smith, Besa Riddle, James R. LeardMann, Cynthia A. Wells, Timothy S. Engel, Charles C. Hoge, Charles W. Adkins, Joyce Blaze, Dan CA Millennium Cohort Study Team TI The physical and mental health of a large military cohort: baseline functional health status of the Millennium Cohort SO BMC PUBLIC HEALTH LA English DT Article ID QUALITY-OF-LIFE; GULF-WAR VETERANS; IRAQ-WAR; GENDER DIFFERENCES; CARE UTILIZATION; WOMEN VETERANS; WHITEHALL-II; US MILITARY; SF-36; PERSONNEL AB Background: The US military is currently involved in large, lengthy, and complex combat operations around the world. Effective military operations require optimal health of deployed service members, and both mental and physical health can be affected by military operations. Methods: Baseline data were collected from 77,047 US service members during 2001-2003 as part of a large, longitudinal, population-based military health study (the Millennium Cohort Study). The authors calculated unadjusted, adjusted, and weighted means for the Medical Outcomes Study Short Form 36-item Survey for Veterans physical (PCS) and mental component summary (MCS) scores over a variety of demographic and military characteristics at baseline. Results: The unadjusted mean PCS and MCS scores for this study were 53.4 (95% confidence interval: 53.3-53.4) and 52.8 (95% confidence interval: 52.7-52.9). Average PCS and MCS scores were slightly more favorable in this military sample compared to those of the US general population of the same age and sex. Factors independently associated with more favorable health status included male gender, being married, higher educational attainment, higher military rank, and Air Force service. Combat specialists had similar health status compared to other military occupations. Having been deployed to Southwest Asia, Bosnia, or Kosovo between 1998 and 2000 was not associated with diminished health status. Conclusion: The baseline health status of this large population-based military cohort is better than that of the US general population of the same age and sex distribution over the same time period, especially in older age groups. Deployment experiences during the period of 1998-2001 were not associated with decreased health status. These data will serve as a useful reference for other military health studies and for future longitudinal analyses. C1 [Smith, Tyler C.; Smith, Besa; LeardMann, Cynthia A.] USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, San Diego, CA USA. [Zamorski, Mark] Univ Ottawa, Dept Family Med, Ottawa, ON, Canada. [Zamorski, Mark] Canadian Forces Hlth Serv Grp Headquarters, Directorate Med Policy, Deployment Hlth Sect, Ottawa, ON, Canada. [Engel, Charles C.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Silver Spring, MD USA. [Riddle, James R.; Wells, Timothy S.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Hoge, Charles W.] Walter Reed Army Inst Res, Dept Psychiat & Behav Sci, Silver Spring, MD USA. [Adkins, Joyce] Pentagon, Off Assistant Secretary Def Hlth Affairs, Force Hlth Protect, Washington, DC USA. [Blaze, Dan] Duke Univ, Med Ctr, Durham, NC USA. RP Smith, TC (reprint author), USN, Hlth Res Ctr, US Dept Def, Ctr Deployment Hlth Res, San Diego, CA USA. EM Tyler.Smith2@med.navy.mil; Zamorski.MA@forces.gc.ca; Besa.Smith@med.navy.mil; James.Riddle@wpafb.af.mil; Cynthia.LeardMann@med.navy.mil; Timothy.Wells@wpafb.af.mil; Charles.Engel@na.amedd.army.mil; Charles.Hoge@na.amedd.army.mil; Joyce.Adkins@deploymenthealth.osd.mil; blaze001@mc.duke.edu NR 64 TC 45 Z9 46 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD NOV 26 PY 2007 VL 7 AR 340 DI 10.1186/1471-2458-7-340 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 256LD UT WOS:000252729400001 PM 18039387 ER PT J AU Badulin, SI Babanin, AV Zakharov, VE Resio, D AF Badulin, Sergei I. Babanin, Alexander V. Zakharov, Vladimir E. Resio, Donald TI Weakly turbulent laws of wind-wave growth SO JOURNAL OF FLUID MECHANICS LA English DT Article ID LINEAR ENERGY TRANSFER; FOLLOWER FIELD-MEASUREMENTS; INTERACTING GRAVITY-WAVES; INPUT SPECTRAL-FUNCTION; GENERATED WAVES; EQUILIBRIUM-RANGE; DIRECTIONAL SPECTRA; DIFFUSION-MODEL; DEEP FLUID; SEA WAVES AB The theory of weak turbulence developed for wind-driven waves in theoretical works and in recent extensive numerical studies concludes that non-dimensional features of self-similar wave growth (i.e. wave energy and characteristic frequency) have to be scaled by internal wave-field properties (fluxes of energy, momentum or wave action) rather than by external attributes (e.g. wind speed) which have been widely adopted since the 1960s. Based on the hypothesis of dominant nonlinear transfer, an asymptotic weakly turbulent relation for the total energy 8 and a characteristic wave frequency omega(*) was derived [Graphics] The self-similarity parameter alpha(ss) was found in the numerical duration-limited experiments and was shown to be naturally varying in a relatively narrow range, being dependent on the energy growth rate only. In this work, the analytical and numerical conclusions are further verified by means of known field dependencies for wave energy growth and peak frequency downshift. A comprehensive set of more than 20 such dependencies, obtained over almost 50 years of field observations, is analysed. The estimates give alpha(ss) very close to the numerical values. They demonstrate that the weakly turbulent law has a general value and describes the wave evolution well, apart from the earliest and full wave development stages when nonlinear transfer competes with wave input and dissipation. C1 Russian Acad Sci, PP Shirshov Inst Oceanog, Moscow, Russia. Swinburne Univ Technol, Melbourne, Vic, Australia. Waves & Solitons LLC, Phoenix, AZ USA. Russian Acad Sci, PN Lebedev Phys Inst, Moscow, Russia. Univ Arizona, Tucson, AZ USA. Waterways Expt Stn, Vicksburg, MS USA. RP Badulin, SI (reprint author), Russian Acad Sci, PP Shirshov Inst Oceanog, Moscow, Russia. RI Babanin, Alexander/A-6676-2008; Zakharov, Vladimir/F-1461-2016; Zakharov, Vladimir/G-7276-2016; Badulin, Sergei/L-6018-2015; OI Badulin, Sergei/0000-0002-3727-4238; Babanin, Alexander/0000-0002-8595-8204; zakharov, vladimir/0000-0001-8855-7185 NR 71 TC 41 Z9 41 U1 0 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD NOV 25 PY 2007 VL 591 BP 339 EP 378 DI 10.1017/S0022112007008282 PG 40 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 238UZ UT WOS:000251474500014 ER PT J AU Eshoo, MW Whitehouse, CA Zoll, ST Massire, C Pennella, TTD Blyn, LB Sampath, R Hall, TA Ecker, JA Desal, A Wasieloski, LP Li, F Turell, MJ Schink, A Rudnick, K Otero, G Weaver, SC Ludwig, GV Hofstadler, SA Ecker, DJ AF Eshoo, Mark W. Whitehouse, Chris A. Zoll, Scott T. Massire, Christian Pennella, Thuy-Trang D. Blyn, Lawrence B. Sampath, Rangarajan Hall, Thomas A. Ecker, Joseph A. Desal, Anjali Wasieloski, Leonard P. Li, Feing Turell, Michael J. Schink, Amy Rudnick, Karl Otero, Glen Weaver, Scott C. Ludwig, George V. Hofstadler, Steven A. Ecker, David J. TI Direct broad-range detection of alphaviruses in mosquito extracts SO VIROLOGY LA English DT Article DE alphavirus; biodefense; emerging pathogen; VEEV; Venezuelan equine encephalitis; Togaviridae; virus detection; mucambo IIID virus; viral diagnostic ID IONIZATION MASS-SPECTROMETRY; SALMON PANCREAS DISEASE; FARMED ATLANTIC SALMON; EQUINE-ENCEPHALITIS; RAPID IDENTIFICATION; SLEEPING DISEASE; RAINBOW-TROUT; PCR ASSAYS; NESTED PCR; VIRUS AB Members of the genus Alphavirus are a diverse group of principally mosquito-borne RNA viruses. There are at least 29 species and many more subtypes of alphaviruses and some are considered potential bioweapons. We have developed a multi-locus RT-PCR followed by electrospray ionization mass spectrometry (RT-PCR/ESI-MS) assay that uses the amplicon base compositions to detect and identify alphaviruses. A small set of primer pairs targeting conserved sites in the alphavirus RNA genome were used to amplify a panel of 3 6 virus isolates representing characterized Old World and New World alphaviruses. Base compositions from the resulting amplicons could be used to unambiguously determine the species or subtype of 35 of the 36 isolates. The assay detected, without culture, Venezuelan equine encephalitis virus (VEEV), Eastern equine encephalitis virus (EEEV), and mixtures of both in pools consisting of laboratory-infected and -uninfected mosquitoes. Further, the assay was used to detect alphaviruses in naturally occurring mosquito vectors collected from locations in South America and Asia. Mosquito pools collected near Iquitos, Peru, were found to contain an alphavirus with a very distinct signature. Subsequent sequence analysis confirmed that the virus was a member of the Mucambo virus species (subtype HID in the VEEV complex). The assay we have developed provides a rapid, accurate, and high-throughput assay for surveillance of alphaviruses. (c) 2007 Elsevier Inc. All rights reserved. C1 Ibis Biosci, Carlsbad, CA 92008 USA. SAIC, San Diego, CA 92121 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. Univ Texas, Med Branch, Galveston, TX 77555 USA. RP Eshoo, MW (reprint author), Ibis Biosci, 1891 Rutherford Rd, Carlsbad, CA 92008 USA. EM meshoo@isisph.com RI Weaver, Scott/D-6490-2011 NR 31 TC 48 Z9 48 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD NOV 25 PY 2007 VL 368 IS 2 BP 286 EP 295 DI 10.1016/j.virol.2007.06.016 PG 10 WC Virology SC Virology GA 230QQ UT WOS:000250891400008 PM 17655905 ER PT J AU Su, HP Golden, JW Gittis, AG Hooper, JW Garboczi, DN AF Su, Hua-Poo Golden, Joseph W. Gittis, Apostolos G. Hooper, Jay W. Garboczi, David N. TI Structural basis for the binding of the neutralizing antibody, 7D11, to the poxvirus L1 protein SO VIROLOGY LA English DT Article DE conformational epitope; vaccinia; poxvirus L1R; neutralizing antibody; fab structure ID VACCINIA VIRUS L1R; MEMBRANE-PROTEIN; SMALLPOX VACCINE; MONOCLONAL-ANTIBODIES; PENETRATION PROTEIN; NONHUMAN-PRIMATES; DISULFIDE BRIDGES; MICE; CHALLENGE; PROTECTION AB Medical countermeasures to prevent or treat smallpox are needed due to the potential use of poxviruses as biological weapons. Safety concerns with the currently available smallpox vaccine indicate a need for research on alternative poxvirus vaccine strategies. Molecular vaccines involving the use of proteins and/or genes and recombinant antibodies are among the strategies under current investigation. The poxvirus L I protein, encoded by the L I R open reading frame, is the target of neutralizing antibodies and has been successfully used as a component of both protein subunit and DNA vaccines. L1-specific monoclonal antibodies (e.g., mouse monoclonal antibody mAb-7D 11, mAb- 10F5) with potent neutralizing activity bind L I in a conformation -specific manner. This suggests that proper folding of the L1 protein used in molecular vaccines will affect the production of neutralizing antibodies and protection. Here, we co-crystallized the Fab fragment of mAb-7D11 with the L1 protein. The crystal structure of the complex between Fab-7D11 and L1 reveals the basis for the conformation-specific binding as recognition of a discontinuous epitope containing two loops that are held together by a disulfide bond. The structure of this important conformational epitope of L I will contribute to the development of molecular poxvirus vaccines and also provides a novel target for anti-poxvirus drugs. In addition, the sequence and structure of Fab-7D11 will contribute to the development of L1-targeted immunotherapeutics. Published by Elsevier Inc. C1 NIAID, Struct Biol Sect, Immunogenet Lab, NIH, Rockville, MD 20852 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Garboczi, DN (reprint author), NIAID, Struct Biol Sect, Immunogenet Lab, NIH, 12441 Parklawn Dr, Rockville, MD 20852 USA. EM dgarboczi@niaid.nih.gov OI Hooper, Jay/0000-0002-4475-0415 FU Intramural NIH HHS [Z01 AI000956-03] NR 47 TC 23 Z9 24 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD NOV 25 PY 2007 VL 368 IS 2 BP 331 EP 341 DI 10.1016/j.virol.2007.06.042 PG 11 WC Virology SC Virology GA 230QQ UT WOS:000250891400013 PM 17688903 ER PT J AU Pethel, SD Corron, NJ Bollt, E AF Pethel, Shawn D. Corron, Ned J. Bollt, Erik TI Deconstructing spatiotemporal chaos using local symbolic dynamics SO PHYSICAL REVIEW LETTERS LA English DT Article ID COUPLED MAP LATTICES AB find that the global symbolic dynamics of a diffusively coupled map lattice is well approximated by a very small local model for weak to moderate coupling strengths. A local symbolic model is a truncation of the full symbolic model to one that considers only a single element and a few neighbors. Using interval analysis, we give rigorous results for a range of coupling strengths and different local model widths. Examples are presented of extracting a local symbolic model from data and of controlling spatiotemporal chaos. C1 USA, RDECOM, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. Clarkson Univ, Dept Math & Comp Sci, Potsdam, NY 13699 USA. RP Pethel, SD (reprint author), USA, RDECOM, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. OI Corron, Ned/0000-0002-3232-5024 NR 18 TC 7 Z9 7 U1 0 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD NOV 23 PY 2007 VL 99 IS 21 AR 214101 DI 10.1103/PhysRevLett.99.214101 PG 4 WC Physics, Multidisciplinary SC Physics GA 233RH UT WOS:000251107500025 PM 18233220 ER PT J AU Mahoney, CR Castellani, J Kramer, FM Young, A Lieberman, HR AF Mahoney, Caroline R. Castellani, John Kramer, F. Matthew Young, Andrew Lieberman, Harris R. TI Tyrosine supplementation mitigates working memory decrements during cold exposure SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE tyrosine; cognition; cold; working memory; body core cooling ID TO-SAMPLE PERFORMANCE; HUMAN THERMOREGULATORY RESPONSES; SALIVARY CORTISOL; BEHAVIORAL DEPRESSION; COGNITIVE PERFORMANCE; BODY-TEMPERATURE; ADRENAL-FUNCTION; STRESS; WATER; RATS AB In rats, dietary supplementation with the amino acid tyrosine (TYR) prevents depletion of central catecholamines observed during acute environmental stress. Concomitant changes in the animals' behavioral responses to stress suggest that TYR might have similar effects on central catecholamines and cognition in humans exposed to environmental stress. This study aimed to determine if severe cold exposure impairs human cognition and if dietary supplementation with TYR would ameliorate such deficits. Volunteers (N = 19) completed three test sessions on different days (35 degrees C control/placebo, similar to 10 degrees C/placebo, similar to 10 degrees C/TYR) using a double-blind, within subjects design. During each session, volunteers completed two 90-minute water immersions and consumed a food bar (150 mg/kg TYR or placebo) before each immersion (total TYR 300 mg/kg). Cognitive performance, mood, and salivary cortisol were assessed. Cortisol was elevated in the cold(p < .01). Volunteers made fewer correct responses on a Match-to-Sample memory measure (p < .05) and reaction time (RT) and errors increased on a choice RT test (p < .01) in the cold. Self-reported tension (p < .01), depression (p < .05) and confusion (p < .01) also increased in the cold. When volunteers consumed TYR, correct responses increased on a Match-to-Sample memory measure (p < .05) and study time for the sample was shorter (p < .05), indicative of more rapid and accurate information processing. Finally, RT on the memory measure revealed a similar pattern across immersions for TYR and thermoneutral conditions, but not cold/placebo (p < .05). This study demonstrates cold exposure degrades cognitive performance and supplementation with TYR alleviates working memory decrements. (C) 2007 Elsevier Inc. All rights reserved. C1 USA, Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Mahoney, CR (reprint author), USA, Soldier Res, Ctr Dev & Engn, Kansas St, Natick, MA 01760 USA. EM caroline.mahoney@natick.army.mil NR 42 TC 49 Z9 51 U1 2 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD NOV 23 PY 2007 VL 92 IS 4 BP 575 EP 582 DI 10.1016/j.physbeh.2007.05.003 PG 8 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA 237XI UT WOS:000251409300006 PM 17585971 ER PT J AU Chan, BL Witt, R Charrow, AP Magee, A Howard, R Pasquina, PF Heilman, KM Tsao, JW AF Chan, Brenda L. Witt, Richard Charrow, Alexandra P. Magee, Amanda Howard, Robin Pasquina, Paul F. Heilman, Kenneth M. Tsao, Jack W. TI Mirror therapy for phantom limb pain SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Chan, BL (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM jtsao@usuhs.mil NR 5 TC 194 Z9 199 U1 2 U2 52 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 22 PY 2007 VL 357 IS 21 BP 2206 EP 2207 DI 10.1056/NEJMc071927 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 233FT UT WOS:000251076500030 PM 18032777 ER PT J AU Banakh, VA Marakasov, DA Vorontsov, MA AF Banakh, V. A. Marakasov, D. A. Vorontsov, M. A. TI Cross-wind profiling based on the scattered wave scintillations in a telescope focus SO APPLIED OPTICS LA English DT Article ID TURBULENT ATMOSPHERE; GENERALIZED SCIDAR; INTENSITY FLUCTUATIONS; SPECKLE PROPAGATION; STATISTICS; RADIATION; TARGET; LAYER AB The problem of wind profile reconstruction from scintillations of an optical wave scattered off a rough surface in a telescope focus plane is considered. Both the expression for the spatiotemporal correlation function and the algorithm of cross-wind velocity and direction profiles reconstruction based on the spatiotemporal spectrum of intensity of an optical wave scattered by a diffuse target in a turbulent atmosphere are presented. Computer simulations performed under conditions of weak optical turbulence show wind profiles reconstruction by the developed algorithm. (C) 2007 Optical Society of America. C1 [Banakh, V. A.; Marakasov, D. A.] Russian Acad Sci, Inst Atmospher Opt, Siberian Branch, Moscow 117901, Russia. [Marakasov, D. A.] Army Res Lab Computat & Informat Sci Directorate, Intelligent Opt Lab, Adelphi, MD 20783 USA. RP Banakh, VA (reprint author), Russian Acad Sci, Inst Atmospher Opt, Siberian Branch, Moscow 117901, Russia. EM banakh@iao.ru; mda@iao.ru; mvorontsov@arl.army.mil NR 36 TC 5 Z9 7 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 20 PY 2007 VL 46 IS 33 BP 8104 EP 8117 DI 10.1364/AO.46.008104 PG 14 WC Optics SC Optics GA 243XK UT WOS:000251830400019 PM 18026550 ER PT J AU Braida, W Christodoulatos, C Ogundipe, A Dermatas, D O'Connor, G AF Braida, Washington Christodoulatos, Christos Ogundipe, Adebayo Dermatas, Dirnitris O'Connor, Gregory TI Electrokinetic treatment of firing ranges containing tungsten-contaminated soils SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article; Proceedings Paper CT 8th International Conference on Protection and Restoration of the Environment CY JUL 03-07, 2006 CL Chania, GREECE SP Tech Univ Crete, Stevens Inst Technol DE tungsten; remediation; electrokinetics ID REMEDIATION; ALLOYS AB Tungsten-based alloys and composites are being used and new formulations are being considered for use in the manufacturing of different types of ammunition. The use of tungsten heavy alloys (WHA) in new munitions systems and tungsten composites in small caliber ammunition could potentially release substantial amounts of this element into the environment. Although tungsten is widely used in industrial and military applications, tungsten's potential environmental and health impacts have not been thoroughly addressed. This necessitates the research and development of remedial technologies to contain and/or remove tungsten from soils that may serve as a source for water contamination. The current work investigates the feasibility of using electrokinetics for the remediation of tungsten-contaminated soils in the presence of other heavy metals of concern such as Cu and Pb with aim to removing W from the soil while stabilizing in situ, Pb and Cu. (C) 2007 Elsevier B.V. All rights reserved. C1 Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. US Army, Environm Technol Dev, Picatinny Arsenal, NJ 07806 USA. RP Braida, W (reprint author), Stevens Inst Technol, Ctr Environm Syst, Castle Point Hudson, Hoboken, NJ 07030 USA. EM wbraida@stevens.edu NR 7 TC 5 Z9 5 U1 3 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD NOV 19 PY 2007 VL 149 IS 3 BP 562 EP 567 DI 10.1016/j.jhazmat.2007.06.114 PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 237VQ UT WOS:000251404900007 PM 17686582 ER PT J AU Israeli, E Merkel, D Constantini, N Yanovich, R Evans, RK Shahar, D Moran, DS AF Israeli, Eran Merkel, Drorit Constantini, Naama Yanovich, Ran Evans, Rachel K. Shahar, Danit Moran, Daniel S. TI Iron deficiency and the role of nutrition among female military recruits SO BLOOD LA English DT Meeting Abstract CT 49th Annual Meeting of the American-Society-of-Hematology CY DEC 08-11, 2007 CL Atlanta, GA SP Amer Soc Hematol C1 [Israeli, Eran] Hadassah Med Ctr, Dept Gastroenterol, IL-91120 Jerusalem, Israel. [Merkel, Drorit] Chaim Sheba Med Ctr, Tel Hashomer, Israel. [Constantini, Naama] Hadassah Med Ctr, Dept Orthoped, IL-91120 Jerusalem, Israel. [Yanovich, Ran; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Shahar, Danit] Ben Gurion Univ Negev, Daniel & Abraham Int Ctr Hlth, IL-84105 Beer Sheva, Israel. RI Shahar, Danit/B-4280-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2007 VL 110 IS 11 MA 3753 BP 5B EP 5B PN 2 PG 1 WC Hematology SC Hematology GA 233OV UT WOS:000251101100009 ER PT J AU Merkel, D Moran, DS Yanovich, R Evans, RK Finestone, AS Constantini, N Israeli, E AF Merkel, Drorit Moran, Daniel S. Yanovich, Ran Evans, Rachel K. Finestone, Aharon S. Constantini, Naama Israeli, Eran TI The association between hematological and inflammatory factors and stress fractures among female military recruits. SO BLOOD LA English DT Meeting Abstract CT 49th Annual Meeting of the American-Society-of-Hematology CY DEC 08-11, 2007 CL Atlanta, GA SP Amer Soc Hematol C1 [Merkel, Drorit] Sheba Med Ctr, Tel Hashomer, Israel. [Moran, Daniel S.; Yanovich, Ran] Sheba Med Ctr, Heller Inst Med Res, Tel Hashomer, Israel. [Evans, Rachel K.] Environm Med Res Inst, USA, Natick, MA USA. [Finestone, Aharon S.] Assaf Harofeh Med Ctr, Dept Orthopaed Surg, Zerrifin, Israel. [Constantini, Naama] Hadassah Hebrew Univ, Med Ctr, Jerusalem, Israel. [Israeli, Eran] Hadassah Med Ctr, Jerusalem, Israel. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2007 VL 110 IS 11 MA 5160 BP 372B EP 373B PN 2 PG 2 WC Hematology SC Hematology GA 233OV UT WOS:000251101102452 ER PT J AU Dale, JK Price, S Tretler, J Aldridge, P Montague, S Davis, J Gill, F Hartman, KR Stork, LC Gnarra, DJ Krishnamurti, L Puck, J Fleisher, T Rao, VK AF Dale, Janet K. Price, Susan Tretler, Jean Aldridge, Patricia Montague, Stephanie Davis, Joie Gill, Fred Hartman, Kip R. Stork, Linda C. Gnarra, David J. Krishnamurti, Lakshmianan Puck, Jennifer Fleisher, Thomas Rao, V. Koneti TI Use of rituximab for refractory immune cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS) SO BLOOD LA English DT Meeting Abstract CT 49th Annual Meeting of the American-Society-of-Hematology CY DEC 08-11, 2007 CL Atlanta, GA SP Amer Soc Hematol C1 [Dale, Janet K.; Price, Susan; Tretler, Jean; Aldridge, Patricia; Montague, Stephanie; Davis, Joie; Gill, Fred; Fleisher, Thomas; Rao, V. Koneti] NIAID, Natl Inst Hlth, NHGRI, Bethesda, MD USA. [Hartman, Kip R.] Walter Reed Army Med Ctr, Washington, DC USA. [Stork, Linda C.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Gnarra, David J.] Childrens Hosp, Omaha, NE USA. [Krishnamurti, Lakshmianan] Childrens Hosp Pittsburgh, Div Hematol Oncol, BMT, Pittsburgh, PA USA. [Puck, Jennifer] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2007 VL 110 IS 11 MA 1319 BP 397A EP 397A PN 1 PG 1 WC Hematology SC Hematology GA 233OS UT WOS:000251100801587 ER PT J AU Binn, LN Sanchez, JL Gaydos, JC AF Binn, Leonard N. Sanchez, Jose L. Gaydos, Joel C. TI Emergence of adenovirus type 14 in US military recruits - A new challenge SO JOURNAL OF INFECTIOUS DISEASES LA English DT Editorial Material ID INFECTION; VACCINES C1 Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD USA. RP Binn, LN (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM leonard.binn@na.amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 16 TC 16 Z9 16 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 IS 10 BP 1436 EP 1437 DI 10.1086/522969 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 231BP UT WOS:000250921800003 PM 18008220 ER PT J AU Bausch, DG Feldmann, H Geisbert, TW Bray, M Sprecher, AG Boumandouki, P Rollin, PE Roth, C AF Bausch, Daniel G. Feldmann, Heinz Geisbert, Thomas W. Bray, Mike Sprecher, A. G. Boumandouki, Paul Rollin, Pierre E. Roth, Cathy CA Winnipeg Filovirus Clin Work Grp TI Outbreaks of filovirus hemorrhagic fever: Time to refocus on the patient SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID EBOLA-VIRUS INFECTION; ATTENUATED RECOMBINANT VACCINE; NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; EFFICACY; CONGO; LIVE AB In the 40 years since the recognition of filoviruses as agents of lethal human disease, there have been no specific advances in antiviral therapies or vaccines and few clinical studies on the efficacy of supportive care. On 20 September 2006, experts from 14 countries representing 68 institutions integrally involved in the response to outbreaks of filovirus hemorrhagic fever gathered at the National Microbiology Laboratory of the Public Health Agency of Canada in Winnipeg to discuss possible remedies for this grim situation, in a unique workshop entitled "Marburg and Ebola Hemorrhagic Fever: Feasibility of Prophylaxis and Therapy." A summary of the opportunities for and challenges to improving treatment of filovirus hemorrhagic fevers is presented here. C1 Tulane Sch Publ Hlth & Trop Med, Dept Trop Med, New Orleans, LA 70112 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NIH, Bethesda, MD 20892 USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada. Med Sans Frontieres, Brussels, Belgium. Minist Hlth Populat, Brazzaville, Congo. WHO, CH-1211 Geneva, Switzerland. RP Bausch, DG (reprint author), Tulane Sch Publ Hlth & Trop Med, Dept Trop Med, 1430 Tulane Ave, New Orleans, LA 70112 USA. EM dbausch@tulane.edu NR 27 TC 31 Z9 33 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S136 EP S141 DI 10.1086/520542 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400004 PM 17940941 ER PT J AU Ebihara, H Theriault, S Neumann, G Alimonti, JB Geisbert, JB Hensley, LE Groseth, A Jones, SM Geisbert, TW Kawaoka, Y Feldmann, H AF Ebihara, Hideki Theriault, Steven Neumann, Gabriele Alimonti, Judie B. Geisbert, Joan B. Hensley, Lisa E. Groseth, Allison Jones, Steven M. Geisbert, Thomas W. Kawaoka, Yoshihiro Feldmann, Heinz TI In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID MARBURG-VIRUS; GUINEA-PIGS; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; FOREIGN GENE; CELL-CULTURE; ZAIRE VIRUS; INFECTION; REPLICATION; PATHOGENESIS AB To facilitate an understanding of the molecular aspects of the pathogenesis of Zaire ebolavirus (ZEBOV) infection, we generated 2 different recombinant viruses expressing enhanced green fluorescent protein (eGFP) from additional transcription units inserted at different positions in the virus genome. These viruses showed in vitro phenotypes similar to that of wild-type ZEBOV (wt-ZEBOV) and were stable over multiple passages. Infection with one of the viruses expressing eGFP produced only mild disease in rhesus macaques, demonstrating a marked attenuation in this animal model. However, in mice lacking signal transducer and activator of transcription 1, both viruses expressing eGFP caused lethal cases of disease that were moderately attenuated, compared with that caused by wt-ZEBOV. In mice, viral replication could be easily tracked by the detection of eGFP-positive cells in tissues, by use of flow cytometry. These findings demonstrate that the incorporation of a foreign gene will attenuate ZEBOV in vivo but that these viruses still have potential for in vitro and in vivo research applications. C1 Univ Tokyo, Int Res Ctr Infect Dis, Dept Special Pathogens, Tokyo, Japan. Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo, Japan. Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Tokyo, Saitama, Japan. Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB, Canada. Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada. Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada. Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NIH, NIAID, Integrated Res Facil, Ft Detrick, MD USA. RP Feldmann, H (reprint author), Publ Hlth Agcy Canada, 1015 Arlington St, Winnipeg, MB R3E 3R2, Canada. EM Hideki_Ebihara@phac-aspc.gc.ca FU NIAID NIH HHS [1-U54-AI-057153] NR 45 TC 38 Z9 38 U1 1 U2 9 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S313 EP S322 DI 10.1086/520590 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400029 PM 17940966 ER PT J AU Geisbert, TW Daddario-DiCaprio, KM Geisbert, JB Young, HA Formenty, P Fritz, EA Larsen, T Hensley, LE AF Geisbert, Thomas W. Daddario-DiCaprio, Kathleen M. Geisbert, Joan B. Young, Howard A. Formenty, Pierre Fritz, Elizabeth A. Larsen, Tom Hensley, Lisa E. TI Marburg virus Angola infection of rhesus macaques: Pathogenesis and treatment with recombinant nematode anticoagulant protein c2 SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID EBOLA HEMORRHAGIC-FEVER; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; TISSUE FACTOR/FACTOR VIIA; AMINO-ACID CHANGES; NONHUMAN-PRIMATES; CYNOMOLGUS MACAQUES; MACROPHAGE TROPISM; AGENT DISEASE; MONKEYS; COAGULATION AB Background. The procoagulant tissue factor (TF) is thought to play a role in the coagulation disorders that characterize filoviral infections. In this study, we evaluated the pathogenesis of lethal infection with the Angola strain of Marburg virus (MARV-Ang) in rhesus macaques and tested the efficacy of recombinant nematode anticoagulant protein c2 (rNAPc2), an inhibitor of TF/factor VIIa, as a potential treatment. Methods. Twelve rhesus macaques were challenged with a high dose (1000 pfu) of MARV-Ang. Six macaques were treated with rNAPc2, and 6 macaques served as control animals. Results. All 6 control animals succumbed to MARV-Ang challenge by day 8 (mean, 7.3 days), whereas 5 of 6 rNAPc2-treated animals died on day 9 and 1 rNAPc2-treated animal survived. The disease course for MARV-Ang infection appeared to progress more rapidly in rhesus macaques than has been previously reported for other strains of MARV. In contrast to Ebola virus (EBOV) infection in macaques, up-regulation of TF was not as striking, and deposition of fibrin was a less prominent pathologic feature of disease in these animals. Conclusions. These data show that the pathogenicity of MARV-Ang infection appears to be consistent with the apparent increased human virulence attributed to this strain. The apparent reduced efficacy of rNAPc2 against MARV-Ang infection, compared with its efficacy against EBOV infection, appears to be associated with differences in TF induction and fibrin deposition. C1 NIH, NIAID, Integrated Res Facil, Ft Detrick, MD USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NCI, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD 21701 USA. WHO, Dept Communicable Dis Surveillance & Response, CH-1211 Geneva, Switzerland. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Dept Microbiol, 715 Albany St,R514, Boston, MA 02118 USA. EM geisbert@bu.edu NR 42 TC 70 Z9 73 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S372 EP S381 DI 10.1086/520608 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400036 PM 17940973 ER PT J AU Hensley, LE Stevens, EL Yan, SB Geisbert, JB Macias, WL Larsen, T Daddario-DiCaprio, KM Cassell, GH Jahrling, PB Geisbert, TW AF Hensley, Lisa E. Stevens, Edward L. Yan, S. Betty Geisbert, Joan B. Macias, William L. Larsen, Tom Daddario-DiCaprio, Kathleen M. Cassell, Gail H. Jahrling, Peter B. Geisbert, Thomas W. TI Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID SEVERE SEPSIS; VIRUS INFECTION; ANTICOAGULANT PATHWAY; NONHUMAN-PRIMATES; UNITED-STATES; SEPTIC SHOCK; PROTECTION; RESPONSES; ALPHA; EPIDEMIOLOGY AB Background. Infection of primates with Zaire ebolavirus (ZEBOV) leads to hypotension, coagulation disorders, and an impaired immune response and, in many ways, resembles severe sepsis. Rapid decreases in plasma levels of protein C are a prominent feature of severe sepsis and ZEBOV hemorrhagic fever (ZHF). Currently, recombinant human activated protein C (rhAPC [Xigris; Eli Lilly]) is licensed for treating human patients with severe sepsis who are at high risk of death. The aim of this study was to test the efficacy of rhAPC as a potential treatment for ZHF. Methods. Fourteen rhesus macaques were challenged with a uniformly lethal dose of ZEBOV; 11 of these monkeys were treated by intravenous infusion with rhAPC beginning 30-60 min after challenge and continuing for 7 days. Three control monkeys received sterile saline in parallel. Results. All 3 control monkeys died on day 8, whereas 2 of the 11 rhAPC-treated monkeys survived. The mean time to death for the rhAPC-treated monkeys that did not survive ZEBOV challenge was 12.6 days. The difference in survival was significant when the rhAPC-treated monkeys were compared with historical controls. Conclusions. The experimental findings provide evidence that ZHF and severe sepsis share underlying mechanisms and may respond to the same therapies. C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. NIH, NIAID, Integrated Res Facil, Ft Detrick, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Lilly Res Labs, Indianapolis, IN USA. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Dept Microbiol, 715 Albany St, Boston, MA 02118 USA. EM geisbert@bu.edu NR 48 TC 83 Z9 93 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S390 EP S399 DI 10.1086/520598 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400038 PM 17940975 ER PT J AU Jahrling, PB Geisbert, JB Swearengen, JR Larsen, T Geisbert, TW AF Jahrling, Peter B. Geisbert, Joan B. Swearengen, James R. Larsen, Thomas Geisbert, Thomas W. TI Ebola hemorrhagic fever: Evaluation of passive immunotherapy in nonhuman primates SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID VIRUS-INFECTION AB The survival of 7 of 8 patients with Ebola virus (EBOV) infection after transfusions of convalescent-phase blood during a 1995 outbreak of EBOV infection is frequently cited as evidence that passive immunotherapy is a viable treatment option. To test whether whole-blood transfusions were more efficacious than passively administered immunoglobulins or monoclonal antibodies, we transfused convalescent-phase blood from EBOV-immune monkeys into naive animals shortly after challenge with EBOV. Although passively acquired antibody titers comparable to those associated with effective vaccination were obtained, all monkeys that had received transfusions succumbed to infection concurrently with control monkeys. These data cast further doubt on the value of passive immunotherapy for the treatment of EBOV infection. C1 NIH, NIAID, Integrated Res Facil, Bethesda, MD 20892 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. Associat Assessment & Accreditat Lab Anim Care I, Rockville, MD USA. RP Jahrling, PB (reprint author), NIH, NIAID, Integrated Res Facil, Bldg 10, Bethesda, MD 20892 USA. EM jahrlingp@niaid.nih.gov NR 16 TC 52 Z9 56 U1 0 U2 8 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S400 EP S403 DI 10.1086/520587 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400039 PM 17940976 ER PT J AU Larsen, T Stevens, EL Davis, KJ Geisbert, JB Daddario-DiCaprio, KM Jahrling, PB Hensley, LE Geisbert, TW AF Larsen, Thomas Stevens, Edward L. Davis, Kelly J. Geisbert, Joan B. Daddario-DiCaprio, Kathleen M. Jahrling, Peter B. Hensley, Lisa E. Geisbert, Thomas W. TI Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID HEMORRHAGIC-FEVER; MONKEYS; CONGO AB Zaire Ebola virus infection in macaques causes a fatal disease with a pathogenesis similar to that in humans. During several independent therapy studies, we noted altered tissue tropism in 6 rhesus macaques that survived longer than those with a typical disease course. The mean time to death for these 6 macaques was 21.7 days, which is significantly longer than the average mean time to death of 8.3 days for 20 untreated historical control animals. In addition to living significantly longer, these 6 animals exhibited a variety of deteriorating clinical signs with pathologic findings that were not seen in the untreated control animals, as well as the presence of viral antigen in the brain, eye, pancreas, thyroid, and lung. We suggest that treatment extended the time course of the disease and permitted the virus to infect tissues not usually affected in the typical model. C1 USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. NIH, NIAID, Integrated Res Facil, Ft Detrick, MD USA. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Dept Microbiol, 715 Albany St, Boston, MA 02118 USA. EM geisbert@bu.edu NR 16 TC 23 Z9 24 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S323 EP S328 DI 10.1086/520589 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400030 PM 17940967 ER PT J AU Lofts, LL Ibrahim, MS Negley, DL Hevey, MC Schmaljohn, AL AF Lofts, Loreen L. Ibrahim, M. Sofi Negley, Diane L. Hevey, Michael C. Schmaljohn, Alan L. TI Genomic differences between guinea pig lethal and nonlethal Marburg virus variants SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID MATRIX PROTEIN VP40; EBOLA-VIRUS; RNA INTERFERENCE; L-GENE; VACCINES; SEQUENCE AB The complete genome sequences of 2 closely related plaque-derived variants of Marburg virus (MARV) species Lake Victoria marburgvirus, strain Musoke, indicate only a few regions of the RNA genome as underlying the differences between the 2 viruses. One variant is >90% lethal for guinea pigs and the other much less virulent, when guinea pigs are challenged with 1000 pfu of virus. Only 4 mutations that result in amino acid changes were identified, 1 in viral matrix protein VP40 and 3 in L, the RNA-dependent RNA polymerase. In addition, 6 differences were identified in noncoding regions of transcribed mRNA, and 1 silent codon change was identified in the L gene. Interestingly, the amino acid mutation identified in VP40 occurs in a nonconserved loop structure between 2 domains that are homologues only among MARV species. The L gene mutations were equally intriguing, clustering near a highly conserved motif in viral RNA-dependent RNA polymerases. C1 USA, Med Res Inst Infect Dis, Div Virol, Viral Pathogenesis & Immunol Branch, Ft Detrick, MD 21702 USA. Battelle Natl Biodef Inst, Natl Bioforens Anal Ctr, Frederick, MD USA. RP Lofts, LL (reprint author), USA, Med Res Inst Infect Dis, MRMC-UIV-P,1425 Porter St, Ft Detrick, MD 21702 USA. EM loreen.lofts@us.army.mil NR 19 TC 25 Z9 26 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S305 EP S312 DI 10.1086/520585 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400028 PM 17940965 ER PT J AU Silvestri, LS Ruthel, G Kallstrom, G Warfield, KL Swenson, DL Nelle, T Iversen, PL Bavari, S Aman, MJ AF Silvestri, Lynn S. Ruthel, Gordon Kallstrom, George Warfield, Kelly L. Swenson, Dana L. Nelle, Timothy Iversen, Patrick L. Bavari, Sina Aman, M. Javad TI Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID MATRIX PROTEIN; BINDING PROPERTIES; VP40; TRAFFICKING; MECHANISMS; DOMAINS; MOTIFS AB Budding of Ebola virus (EBOV) particles from the plasma membrane of infected cells requires viral and host proteins. EBOV virus matrix protein VP40 recruits TSG101, an ESCRT-1 (host cell endosomal sorting complex required for transport-1) complex protein in the vacuolar protein sorting (vps) pathway, to the plasma membrane during budding. Involvement of other vps proteins in EBOV budding has not been established. Therefore, we used VP40 deletion analysis, virus-like particle-release assays, and confocal microscopy to investigate the potential role of ESCRT-1 proteins VPS4, VPS28, and VPS37B in EBOV budding. We found that VP40 could redirect each protein from endosomes to the cell surface independently of TSG101 interaction. A lack of VPS4 adenosine triphosphatase activity reduced budding by up to 80%. Inhibition of VPS4 gene expression by use of phosphorodiamidite morpholino antisense oligonucleotides protected mice from lethal EBOV infection. These data show that EBOV can use vps proteins independently of TSG101 for budding and reveal VPS4 as a potential target for filovirus therapeutics. C1 Integrated BioTherapeut Inc, Frederick, MD 21704 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. AVI BioPharm, Corvallis, OR USA. RP Aman, MJ (reprint author), Integrated BioTherapeut Inc, 4539 Metropolitan Ct, Frederick, MD 21704 USA. EM javad@integratedbiotherapeutics.com NR 20 TC 17 Z9 19 U1 1 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S264 EP S270 DI 10.1086/520610 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400022 PM 17940959 ER PT J AU Warfield, KL Posten, NA Swenson, DL Olinger, GG Esposito, D Gillette, WK Hopkins, RF Costantino, J Panchal, RG Hartley, JL Aman, MJ Bavari, S AF Warfield, Kelly L. Posten, Nichole A. Swenson, Dana L. Olinger, Gene G. Esposito, Dominic Gillette, William K. Hopkins, Ralph F. Costantino, Julie Panchal, Rekha G. Hartley, James L. Aman, M. Javad Bavari, Sina TI Filovirus-like particles produced in insect cells: Immunogenicity and protection in rodents SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID VIRUS-LIKE PARTICLES; EBOLA-VIRUS; MARBURG-VIRUS; DENDRITIC CELLS; MATRIX PROTEIN; GUINEA-PIGS; BACULOVIRUS VECTORS; VACCINES; GLYCOPROTEIN; VP40 AB Background. Virus-like particles (VLPs) of Ebola virus (EBOV) and Marburg virus (MARV) produced in human 293T embryonic kidney cells have been shown to be effective vaccines against filoviral infection. In this study, we explored alternative strategies for production of filovirus-like particle-based vaccines, to accelerate the development process. The goal of this work was to increase the yield of VLPs, while retaining their immunogenic properties. Methods. Ebola and Marburg VLPs (eVLPs and mVLPs, respectively) were generated by use of recombinant baculovirus constructs expressing glycoprotein, VP40 matrix protein, and nucleoprotein from coinfected insect cells. The baculovirus-derived eVLPs and mVLPs were characterized biochemically, and then the immune responses produced by the eVLPs in insect cells were studied further. Results. The baculovirus-derived eVLPs elicited maturation of human myeloid dendritic cells (DCs), indicating their immunogenic properties. Mice vaccinated with insect cell-derived eVLPs generated antibody and cellular responses equivalent to those vaccinated with mammalian 293T cell-derived eVLPs and were protected from EBOV challenge in a dose-dependent manner. Conclusion. Together, these data suggest that filovirus-like particles produced by baculovirus expression systems, which are amenable to large-scale production, are highly immunogenic and are suitable as safe and effective vaccines for the prevention of filoviral infection. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NCI, Sci Applicat Int Corp, Prot Express Lab, Frederick, MD 21701 USA. NCI, Sci Applicat Int Corp, Target Struct Based Drug Discovery Grp, Frederick, MD 21701 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM kelly.warfield@us.army.mil; sina.bavari@us.army.mil OI Olinger, Gene/0000-0001-7338-0292 FU NCI NIH HHS [N01-CO-12400] NR 40 TC 39 Z9 42 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S421 EP S429 DI 10.1086/520612 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400042 PM 17940979 ER PT J AU Warfield, KL Swenson, DL Olinger, GG Kalina, WV Viard, M Aitichou, M Chi, X Ibrahim, S Blumenthal, R Raviv, Y Bavari, S Aman, MJ AF Warfield, Kelly L. Swenson, Dana L. Olinger, Gene G. Kalina, Warren V. Viard, Mathias Aitichou, Mohamed Chi, Xiaoli Ibrahim, Sofi Blumenthal, Robert Raviv, Yossef Bavari, Sina Aman, M. Javad TI Ebola virus inactivation with preservation of antigenic and structural integrity by a photoinducible alkylating agent SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID PROTECT GUINEA-PIGS; HEMORRHAGIC-FEVER; BIOLOGICAL-MEMBRANES; NONHUMAN-PRIMATES; POLIOVIRUS VACCINATION; MONOCLONAL-ANTIBODIES; PARTICLES PROTECT; CUTTER INCIDENT; UNITED-STATES; INFECTION AB Current methods for inactivating filoviruses are limited to high doses of irradiation or formalin treatment, which may cause structural perturbations that are reflected by poor immunogenicity. In this report, we describe a novel inactivation technique for Zaire Ebola virus (ZEBOV) that uses the photoinduced alkylating probe 1,5-iodonaphthylazide (INA). INA is incorporated into lipid bilayers and, when activated by ultraviolet irradiation, alkylates the proteins therein. INA treatment of ZEBOV resulted in the complete loss of infectivity in cells. Results of electron microscopy and virus-capture assays suggested the preservation of conformational surface epitopes. Challenge with 50,000 pfu of INA-inactivated, mouse-adapted ZEBOV did not cause disease or death in mice. A single vaccination with INA-inactivated ZEBOV (equivalent to 5 X 10(4)pfu) protected mice against lethal challenge with 1000 pfu of ZEBOV. INA- inactivated virus induced a protective response in 100% of mice when administered 3 days before challenge. Thus, INA may have significant potential for the development of vaccines and immunotherapeutics for filoviruses and other enveloped viruses. C1 Integrat BioTherapeut Inc, Frederick, MD 21704 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD USA. NCI, Ctr Canc Res Nanobiol Program, Frederick, MD 21701 USA. NCI, Sci Appl Int Corp, Basic Program, Frederick, MD 21701 USA. RP Aman, MJ (reprint author), Integrat BioTherapeut Inc, 4539 Metropolitan Ct, Frederick, MD 21704 USA. EM javad@integratedbiotherapeutics.com OI Olinger, Gene/0000-0001-7338-0292 FU Intramural NIH HHS; NCI NIH HHS [N01-CO-12400] NR 41 TC 30 Z9 31 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S276 EP S283 DI 10.1086/520605 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400024 PM 17940961 ER PT J AU Warfield, KL Swenson, DL Olinger, GG Kalina, WV Aman, MJ Bavari, S AF Warfield, Kelly L. Swenson, Dana L. Olinger, Gene G. Kalina, Warren V. Aman, M. Javad Bavari, Sina TI Ebola virus-like particle-based vaccine protects nonhuman primates against lethal Ebola virus challenge SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Symposium on Recent Advances and Future Challenges in Filovirus Research CY SEP, 2006 CL Winnipeg, CANADA ID EQUINE ENCEPHALITIS-VIRUS; T-CELL RESPONSES; MARBURG VIRUS; GUINEA-PIGS; DNA VACCINES; NEUTRALIZING ANTIBODIES; INFECTION; GLYCOPROTEIN; VP24; GP AB Background. Currently, there are no licensed vaccines or therapeutics for the prevention or treatment of infection by the highly lethal filoviruses, Ebola virus (EBOV) and Marburg virus (MARV), in humans. We previously had demonstrated the protective efficacy of virus-like particle (VLP)-based vaccines against EBOV and MARV infection in rodents. Methods. To determine the efficacy of vaccination with Ebola VLPs (eVLPs) in nonhuman primates, we vaccinated cynomolgus macaques with eVLPs containing EBOV glycoprotein (GP), nucleoprotein (NP), and VP40 matrix protein and challenged the macaques with 1000 pfu of EBOV. Results. Serum samples from the eVLP-vaccinated nonhuman primates demonstrated EBOV-specific antibody titers, as measured by enzyme-linked immunosorbent assay, complement-mediated lysis assay, and antibody-dependent cell-mediated cytotoxicity assay. CD44(+) T cells from eVLP-vaccinated macaques but not from a naive macaque responded with vigorous production of tumor necrosis factor-alpha after EBOV-peptide stimulation. All 5 eVLP-vaccinated monkeys survived challenge without clinical or laboratory signs of EBOV infection, whereas the control animal died of infection. Conclusion. On the basis of safety and efficacy, eVLPs represent a promising filovirus vaccine for use in humans. C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM kelly.warfield@us.army.mil; sina.bavari@us.army.mil OI Olinger, Gene/0000-0001-7338-0292 NR 42 TC 125 Z9 137 U1 3 U2 25 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2007 VL 196 SU 2 BP S430 EP S437 DI 10.1086/520583 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233KS UT WOS:000251090400043 PM 17940980 ER PT J AU Daly, J Steinfeld, G Moyer, DK Holcomb, FH AF Daly, Joseph Steinfeld, George Moyer, David K. Holcomb, Franklin H. TI Molten carbonate fuel cell operation with dual fuel flexibility SO JOURNAL OF POWER SOURCES LA English DT Article DE fuel cell; dual fuel; fuel swap; propane; critical power AB The ability to operate highly efficient, pollution-free, distributed-generation power plants on either natural gas or HD-5 grade propane is of interest to the U.S. Army and the U.S. Department of Homeland Security as secure power for critical power operations. To address this interest, Concurrent Technologies Corporation (CTC) teamed with FuelCell Energy (FCE) to test an internally reforming 250kW carbonate fuel cell using HD-5 propane. This fuel cell power plant, originally designed to operate on pipeline natural gas or digester gas, was modified for dual fuel operation (natural gas and propane). Fuel cell operation using HD-5 propane was demonstrated for over 3900 It and achieved high-electrical efficiency (45.7-47.1% lower heating value (LHV)) over a broad range of power outputs. In addition, instantaneous and on-load fuel switching from natural gas to propane and back was demonstrated without loss of power. This dual fuel power plant operates efficiently on either fuel and provides the U.S. Army and other power users with a viable technology solution for critical power operations. (C) 2007 Elsevier B.V. All rights reserved. C1 USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. FuelCell Energy Inc, Danbury, CT 06813 USA. Concurrent Technol Corp, Johnstown, PA 15904 USA. RP Holcomb, FH (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61822 USA. EM Franklin.H.Holcomb@erdc.usace.army.mil NR 14 TC 5 Z9 5 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD NOV 15 PY 2007 VL 173 IS 2 BP 925 EP 934 DI 10.1016/j.jpowsour.2007.08.035 PG 10 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 231FQ UT WOS:000250932300040 ER PT J AU Auger, JC Aptowicz, KB Pinnick, RG Pan, YL Chang, RK AF Auger, Jean-Claude Aptowicz, Kevin B. Pinnick, Ronald G. Pan, Yong-Le Chang, Richard K. TI Angularly resolved light scattering from aerosolized spores: observations and calculations SO OPTICS LETTERS LA English DT Article ID PARTICLES AB Angularly resolved elastic light scattering patterns from individual aerosolized Bacillus subtilis spores were qualitatively compared with simulations. Two-dimensional angular optical scattering patterns of the spores were collected for polar scattering angles varying from approximately 77 degrees to 130 degrees and azimuthal angles varying from 0 degrees to 360 degrees. Computations were performed with single T-matrix formalism by simulating a spore with three different particle shapes: (1) a finite-length cylinder with spherical end caps, (2) a spheroid, and (3) two spheres in contact. Excellent agreement between computation and measurement was found for the finite-length cylinder with spherical end caps, poorer agreement was found for the spheroids, and the poorest agreement was for the two spheres in contact. (c) 2007 Optical Society of America. C1 [Aptowicz, Kevin B.] W Chester Univ, Dept Phys, W Chester, PA 19383 USA. [Auger, Jean-Claude; Pan, Yong-Le; Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. [Pinnick, Ronald G.] USA, Res Lab, Adelphi, MD 20783 USA. RP Aptowicz, KB (reprint author), W Chester Univ, Dept Phys, W Chester, PA 19383 USA. EM kaptowicz@wcupa.edu NR 13 TC 20 Z9 20 U1 0 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD NOV 15 PY 2007 VL 32 IS 22 BP 3358 EP 3360 DI 10.1364/OL.32.003358 PG 3 WC Optics SC Optics GA 242SZ UT WOS:000251747600046 PM 18026307 ER PT J AU Fekete, ZA Wilusz, E Karasz, FE Visy, C AF Fekete, Zoltan A. Wilusz, Eugene Karasz, Frank E. Visy, Csaba TI Ion beam irradiation of conjugated polymers for preparing new membrane materials - A theoretical study SO SEPARATION AND PURIFICATION TECHNOLOGY LA English DT Article; Proceedings Paper CT 2nd Membrane Science and Technology Conference of Visegrad Countries (PERMEA 2005) CY SEP 18-22, 2005 CL Polanica Zdroj, POLAND DE Monte Carlo simulation; computer modeling; ion beam irradiation; conducting polymers; polythiophenes; SRIM/TRIM program ID HYPERTHERMAL ATOMIC OXYGEN; GAS SEPARATION MEMBRANES; CONDUCTING POLYMERS; POLYIMIDE FILMS; MODIFIED POLYSILOXANE; CHEMICAL ALTERATION; SURFACE-PROPERTIES; PYRROLE FILM; THIN-FILMS; PLASMA AB Conjugated polymers are attractive novel materials whose properties may be tunable after their primary synthesis, by changing their redox state along with their charge while concomitantly dedoping/redoping with appropriate counterions. They can also be made into conductive "synthetic metals" that can be incorporated into electronic circuitry in place of traditional conductors and semiconductors, besides serving as active sensing elements. Their use in sensors is already a maturing field of research, while the perspective of using them in gas separation and pervaporation applications is beginning to emerge. Permeation properties of membranes can be controlled by medium energy (up to a few hundred keV) ion beam irradiation. We present a systematic mathematical modeling approach to describing medium energy (up to a few hundred kcV) ion beam irradiation, which allows to predict implantation and damage depths in any given polymer, for any ions with arbitrarily chosen atomic number and energy. (C) 2006 Elsevier B.V. All rights reserved. C1 Univ Szeged, Dept Phys Chem, H-6701 Szeged, Hungary. USA, Natick Soldier Ctr, Natick, MA 01760 USA. Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA. RP Fekete, ZA (reprint author), Univ Szeged, Dept Phys Chem, PO Box 105, H-6701 Szeged, Hungary. EM SEPPUR.pub.zaf@sparneater.org RI Fekete, Zoltan/C-7019-2008 OI Fekete, Zoltan/0000-0002-7677-2678 NR 59 TC 5 Z9 5 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1383-5866 J9 SEP PURIF TECHNOL JI Sep. Purif. Technol. PD NOV 15 PY 2007 VL 57 IS 3 BP 440 EP 443 DI 10.1016/j.seppur.2006.04.014 PG 4 WC Engineering, Chemical SC Engineering GA 231RA UT WOS:000250965500008 ER PT J AU Cheh, G Lenke, LG Lehman, RA Kim, YJ Nunley, R Bridwell, KH AF Cheh, Gene Lenke, Lawrence G. Lehman, Ronald A., Jr. Kim, Yongjung J. Nunley, Ryan Bridwell, Keith H. TI The reliability of preoperative supine radiographs to predict the amount of curve flexibility in adolescent idiopathic scoliosis SO SPINE LA English DT Article DE adolescent idiopathic scoliosis; side-bending radiographs; supine preoperative coronal radiographs ID COTREL-DUBOUSSET INSTRUMENTATION; SELECTIVE FUSION; THORACIC CURVE; LUMBAR CURVE; TRACTION; PRONE AB Study Design. Retrospective review. Objective. To determine the reliability of supine long-cassette radiographs as compared with side-bending films in predicting curve flexibility in operative cases of adolescent idiopathic scoliosis (AIS). Summary of Background Data. The value of side-bending films is important in the classification of AIS, as well as predicting curve flexibility. Methods. A total of 675 patients with a diagnosis of operative AIS were evaluated. All curves were classified by the Lenke classification. Coronal parameters included: proximal thoracic ( PT), main thoracic (MT), and thoraco-lumbar/lumbar (TL/L) Cobb measurements; sagittal data including: T2-T5, T5-T12, and TL/L measurements. Curves were divided into Lenke Types 1 (N = 263), 2 ( N = 118), 3 ( N = 52), 4 ( N = 31), 5 ( N = 57), and 6 ( N = 54). Lenke Types 1 to 4 ( Group I-MT Major) were compared with Types 5 and 6 ( Group II-TL/L Major). Results. For Group I, MT supine films were highly predictive of MT side-bending while TL/L supine films were highly predictive of TL/L side-bending and standing films. An equation was derived to predict the value of the side-bending radiographs for each part of the curve. For Group II, MT supine films were highly predictive of MT side-bending and standing films. TL/L supine films were highly predictive of TL/L side-bending and standing films. Contingency table analysis for Group I resulted in the supine film providing a strong statistical ability to predict a nonstructural PT curve ( sensitivity = 0.952, PPV = 0.864, NPV = 0.865) and also a nonstructural TL/L curve ( sensitivity = 0.958, PPV = 0.916). Similarly, in Group II, we found a strong statistical ability to predict a nonstructural PT ( sensitivity 1.00, PPV = 0.982, NPV = 1.00) and a nonstructural MT curve ( sensitivity 0.789, specificity = 0.842, PPV = 0.833, NPV = 0.80). Conclusion. A single preoperative supine radiograph is highly predictive of side-bending radiographs and can be used as an adjunct to predicting curve type, flexibility, and structurality. Thus, this singular, reproducible, and non-effort-related radiograph can potentially replace the need for dual side-bending films. C1 Wooridul Spine Hosp, Seoul, South Korea. Washington Univ, Sch Med, St Louis, MO 63110 USA. Walter Reed Army Med Ctr, Washington, DC USA. Hosp Special Surg, New York, NY USA. RP Lenke, LG (reprint author), Washington Univ, Sch Med, Dept Orthoped Surg, One Barnes Jewish Hosp Plaza,suite 11300,W Pavili, St Louis, MO 63110 USA. EM lenkel@wustl.edu NR 20 TC 18 Z9 21 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD NOV 15 PY 2007 VL 32 IS 24 BP 2668 EP 2672 PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 238JA UT WOS:000251442400006 PM 18007242 ER PT J AU Lehman, RA Lenke, LG Keeler, KA Kim, YJ Cheh, G AF Lehman, Ronald A. Lenke, Lawrence G. Keeler, Kathryn A. Kim, Yongjung J. Cheh, Gene TI Computed tomography evaluation of pedicle screws placed in the pediatric deformed spine over an 8-year period SO SPINE LA English DT Article DE scoliosis; kyphosis; pedicle screws; CT scans; free-hand technique; accuracy ID THORACIC PEDICLE; IDIOPATHIC SCOLIOSIS; MORPHOMETRIC-ANALYSIS; PLAIN RADIOGRAPHS; LUMBAR VERTEBRAE; ACCURACY; FIXATION; SAFE; DEFORMITIES; CURVES AB Study Design. A retrospective review. Objective. To evaluate the incremental accuracy of pedicle screws used in spinal deformity via a free-hand technique at a single institution over an 8-year period. Summary of Background Data. The in vivo accuracy of free-hand pedicle screws placed throughout the deformed spine as evaluated by computed tomography (CT) scanning is unknown over a long time period. Methods. A total of 1023 pedicle screws inserted from T1 to L4 in 60 patients ( 928 screws in 54 scoliosis patients and 95 screws in 6 kyphosis patients) over an 8-year period were investigated via postoperative CT scans. Patients were divided into 3 groups ( group I = 1998-1999, group II = 2001-2002, and group III = 2005). All pedicle screws were inserted via the free-hand technique using anatomic landmarks, specific entry sites, neurophysiologic, and radiographic confirmation. Pedicle screw position on CT scan was graded as acceptable versus violated, defined as the screw axis being outside the pedicle wall. Results. One hundred seven of 1023 pedicle screws (10.5%) demonstrated significant mediolateral pedicle wall violations ( 19 medial vs. 88 lateral, P = 0.001). groups I and III had significantly higher lateral wall violations than group II ( P < 0.05) as did the kyphotic spines ( vs. scoliotic spine, P < 0.05). There were significantly more screws placed in the periapical region over time ( P < 0.0001), with left-sided lateral violations (T5-T8) increasing from group II to group III, while the number of medial violations significantly decreased with time ( P < 0.0001). Pedicle screws placed on the right side showed a significant decrease in accuracy from group II to group III ( P = 0.03). The average transverse angle of the acceptable screws was 15.3 which was significantly different from the medial (23.0 degrees, P < 0.001) and lateral (10.6 degrees, P < 0.001) violations between group I and group II. No screws demonstrated neurologic, vascular, or visceral complications. Conclusion. Overall accuracy of acceptable screws using the free-hand pedicle screw placement technique in the deformed spine was 89.5%, without any neurologic, vascular, or visceral complications over an 8-year period. The rate of medial violations decreased with time, as the number of screws placed in the periapical region increased. C1 Walter Reed Army Med Ctr, Washington, DC USA. Washington Univ, Sch Med, St Louis, MO 63130 USA. Hosp Special Surg, New York, NY USA. Wooridul Spine Hosp, Seoul, South Korea. RP Lenke, LG (reprint author), Washington Univ Orthoped, 660 S Euclid Ave,Campus Box 8233, St Louis, MO 63110 USA. EM lenkel@wustl.edu NR 33 TC 54 Z9 56 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD NOV 15 PY 2007 VL 32 IS 24 BP 2679 EP 2684 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 238JA UT WOS:000251442400008 PM 18007244 ER PT J AU Kuhns, CA Bridwell, KH Lenke, LG Amor, C Lehman, RA Buchowski, JM Edwards, C Christine, B AF Kuhns, Craig A. Bridwell, Keith H. Lenke, Lawrence G. Amor, Courtney Lehman, Ronald A. Buchowski, Jacob M. Edwards, Charles, II Christine, Baldus TI Thoracolumbar deformity arthrodesis stopping at L5 - Fate of the L5-S1 disc, minimum 5-year follow-up SO SPINE LA English DT Article DE deformity; adjacent segment disease; fusion; instrumentation; revision surgery; outcomes measures ID ADULT SCOLIOSIS; SACRUM; FUSION; SPINE; FIXATION; SCREWS AB Study Design. A retrospective long-term follow-up study. Objective. Evaluate the fate of L5-S1 disc analyzing subsequent disc degeneration and associated risk factors for degeneration at minimum 5-year follow-up ( average 9-year follow-up). Summary of Background Data. Two previous studies reported the results of long deformity fusions terminating at L5 with minimum 2-year follow-up only. Methods. Thirty-one consecutive patients with an average age of 45 years ( range, 20-62 years) were fused from the thoracic spine to L5 and were evaluated at a mean follow-up of 9.4 years ( range, 5-20.1 year). Patients were evaluated before surgery, after surgery, and latest follow-up with radiographs and Scoliosis Research Society Patient Questionnaire-24 scores. Disc degeneration using validated radiographic Weiner grades. Grade 0 to 1 discs were "healthy" and Grade 2 to 3 were degenerated. Patients with "healthy" discs preoperative that subsequently degenerated were designated subsequent advanced degeneration ( SAD). Results. Two out of 31 patients had preoperative advanced degeneration of the L5-S1 disc ( Weiner grade 2-3). Three additional patients had an early revision to the sacrum secondary to sagittal imbalance not thought to be related to SAD. Twenty-six out of 31 patients were assessed as "healthy discs" preoperative ( Weiner grade 0-1) and were evaluated for SAD. By latest follow-up, L5-S1 SAD developed in 18 of these 26 patients (69%). Risk factors for the development of SAD included long fusions extending into the upper thoracic spine down to L5 ( P = 0.02) and having a circumferential lumbar fusion ( P = 0.02). Although preoperative sagittal balance was not significantly different between the "healthy" and SAD group, sagittal balance at follow-up was: C7 plumb > 5 cm in 67% of SAD patients and only 13% of "healthy" disc patients ( P = 0.009). There was a trend toward inferior Scoliosis Research Society Patient Questionnaire-24 pain scores at follow-up in SAD patients ( average score 4.1 vs. 3.4, P = 0.13). Eleven out of 30 patients (35%) had subsequent spinal surgery with 7 of 31 (23%) having extension of their fusion to the sacrum. An additional 6 of 31 (19%) were considered for extension to the sacrum but comorbidities precluded surgery ( 3 patients) or the patients declined further surgery ( 3 patients). Conclusion. Advanced L5-S1 DDD developed in 69% of deformity patients after long fusions to L5 with 5 to 15 year follow-up. SAD frequently results in significant positive sagittal balance at a minimum 5-year follow-up. Long fusions to the upper thoracic spine down to L5 and circumferential fusion may further promote subsequent L5-S1 disc degeneration. C1 Univ Missouri, Dept Orthoped Surg, Columbia, MO 65211 USA. Washington Univ, Sch Med, Dept Orthoped Surg, St Louis, MO 63130 USA. Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC USA. Maryland Spine Ctr, Mercy Med Ctr, Baltimore, MD USA. RP Bridwell, KH (reprint author), Washington Univ, One Barnes-Jewish Hosp Plaza,Suite 11300 W Pavili, St Louis, MO 63110 USA. EM bridwellk@wudosis.wustl.edu OI Buchowski, Jacob/0000-0001-8880-8490 NR 14 TC 37 Z9 44 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD NOV 15 PY 2007 VL 32 IS 24 BP 2771 EP 2776 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 238JA UT WOS:000251442400023 PM 18007259 ER PT J AU Milliken, CS Auchterlonie, JL Hoge, CW AF Milliken, Charles S. Auchterlonie, Jennifer L. Hoge, Charles W. TI Longitudinal assessment of mental health problems among active and reserve component soldiers returning from the Iraq war SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; PRIMARY-CARE; MILITARY PERSONNEL; VETERANS; AFGHANISTAN; THERAPY; TRAUMA AB Context To promote early identification of mental health problems among combat veterans, the Department of Defense initiated population-wide screening at 2 time points, immediately on return from deployment and 3 to 6 months later. A previous article focusing only on the initial screening is likely to have underestimated the mental health burden. Objective To measure the mental health needs among soldiers returning from Iraq and the association of screening with mental health care utilization. Design, Setting, and Participants Population-based, longitudinal descriptive study of the initial large cohort of 88 235 US soldiers returning from Iraq who completed both a Post-Deployment Health Assessment ( PDHA) and a Post-Deployment Health Re-Assessment (PDHRA) with a median of 6 months between the 2 assessments. Main Outcome Measures Screening positive for posttraumatic stress disorder ( PTSD), major depression, alcohol misuse, or other mental health problems; referral and use of mental health services. Results Soldiers reported more mental health concerns and were referred at significantly higher rates from the PDHRA than from the PDHA. Based on the combined screening, clinicians identified 20.3% of active and 42.4% of reserve component soldiers as requiring mental health treatment. Concerns about interpersonal conflict increased 4-fold. Soldiers frequently reported alcohol concerns, yet very few were referred to alcohol treatment. Most soldiers who used mental health services had not been referred, even though the majority accessed care within 30 days following the screening. Although soldiers were much more likely to report PTSD symptoms on the PDHRA than on the PDHA, 49% to 59% of those who had PTSD symptoms identified on the PDHA improved by the time they took the PDHRA. There was no direct relationship of referral or treatment with symptom improvement. Conclusions Rescreening soldiers several months after their return from Iraq identified a large cohort missed on initial screening. The large clinical burden recently reported among veterans presenting to Veterans Affairs facilities seems to exist within months of returning home, highlighting the need to enhance military mental health care during this period. Increased relationship problems underscore shortcomings in services for family members. Reserve component soldiers who had returned to civilian status were referred at higher rates on the PDHRA, which could reflect their concerns about their ongoing health coverage. Lack of confidentiality may deter soldiers with alcohol problems from accessing treatment. In the context of an overburdened system of care, the effectiveness of population mental health screening was difficult to ascertain. C1 USA, Walter Reed Army Inst Res, Div Psychiat & Neurosci, Med Res & Mat Command, Silver Spring, MD 20910 USA. USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD USA. RP Milliken, CS (reprint author), USA, Walter Reed Army Inst Res, Div Psychiat & Neurosci, Med Res & Mat Command, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.milliken@us.army.mil NR 35 TC 771 Z9 778 U1 9 U2 86 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 14 PY 2007 VL 298 IS 18 BP 2141 EP 2148 DI 10.1001/jama.298.18.2141 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 230II UT WOS:000250869800019 PM 18000197 ER PT J AU Pradeep, N Kim, DI Grobelny, J Hawa, T Henz, B Zachariah, MR AF Pradeep, N. Kim, D. -I. Grobelny, J. Hawa, T. Henz, B. Zachariah, M. R. TI Ductility at the nanoscale: Deformation and fracture of adhesive contacts using atomic force microscopy SO APPLIED PHYSICS LETTERS LA English DT Article ID SURFACES; METALS; NANOINDENTATION; DYNAMICS; SILICON; MODEL AB Fracture of nanosize contacts formed between spherical probes and flat surfaces is studied using an atomic force microscope in an ultrahigh vacuum environment. Analysis of the observed deformation during the fracture process indicates significant material extensions for both gold and silica contacts. The separation process begins with an elastic deformation followed by plastic flow of material with atomic rearrangements close to the separation. Classical molecular dynamics studies show similarity between gold and silicon, materials that exhibit entirely different fracture behavior at macroscopic scale. This direct experimental evidence suggests that fracture at nanoscale occurs through a ductile process. (c) 2007 American Institute of Physics. C1 Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. Univ Lodz, Natl Inst Stand & Technol, PL-90236 Lodz, Poland. Univ Maryland, Natl Inst Stand & Technol, Gaithersburg, MD 20742 USA. US Army Res Lab, Gaithersburg, MD 21005 USA. RP Pradeep, N (reprint author), Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. EM pradeep.namboodiri@nist.gov OI Grobelny, Jaroslaw/0000-0003-2648-2186 NR 23 TC 13 Z9 13 U1 1 U2 8 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 12 PY 2007 VL 91 IS 20 AR 203114 DI 10.1063/1.2815648 PG 3 WC Physics, Applied SC Physics GA 232FK UT WOS:000251003500098 ER PT J AU Robinson, TL Michalkova, A Gorb, L Leszczynski, J AF Robinson, T. L. Michalkova, A. Gorb, L. Leszczynski, J. TI Hydrogen bonding of thymine and uracil with surface of dickite: An ab initio study SO JOURNAL OF MOLECULAR STRUCTURE LA English DT Article DE thymine; uracil; hydrogen bonding; adsorption; clay ID DENSITY-FUNCTIONAL THEORY; CYTOSINE BASE-PAIRS; BACILLUS-SUBTILIS; CLAY-MINERALS; WATER COMPLEXES; ADENINE-THYMINE; PROTON-TRANSFER; DNA; MONTMORILLONITE; TRANSFORMATION AB The density functional theory (DFT) by means of the B3LYP functional and the 6-31G(d) basis set has been applied to analyze the hydrogen boding of selected nucleic acid bases (thymine and uracil) with the representative cluster models of the clay mineral, dickite. The results obtained from this investigation reveal that the formation of hydrogen bonds accounts for the stabilization of thymine and uracil on the mineral surface. The intermolecular distances and strength of the hydrogen bonds depend on the type of the surface (tetrahedral or octahedral) and on the hydration of the surface. Generally, thymine and uracil are less stable on the tetrahedral surface than on the octahedral surface. The most energetically favorable adsorption is predicted in the case of the system containing hydrated octahedral mineral fragment. The adsorption of thymine on the surface of dickite results in changes in geometry and polarization of thymine. These effects are more significant in the case of the octahedral adsorption than for the tetrahedral adsorption. (C) 2007 Elsevier B.V. All rights reserved. C1 [Robinson, T. L.; Michalkova, A.; Leszczynski, J.] Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Gorb, L.] USA, ERDC, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, 1400 JR Lynch St,POB 17910, Jackson, MS 39217 USA. EM jerzy@ccmsi.us NR 73 TC 15 Z9 16 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2860 J9 J MOL STRUCT JI J. Mol. Struct. PD NOV 12 PY 2007 VL 844 BP 48 EP 58 DI 10.1016/j.moistruc.2007.03.002 PG 11 WC Chemistry, Physical SC Chemistry GA 241LZ UT WOS:000251659200007 ER PT J AU Bergmann-Leitner, ES Duncan, EH Leitner, WW Neutzner, A Savranskaya, T Angov, E Tsokos, GC AF Bergmann-Leitner, Elke S. Duncan, Elizabeth H. Leitner, Wolfgang W. Neutzner, Albert Savranskaya, Tatyana Angov, Evelina Tsokos, George C. TI C3d-defined complement receptor-binding peptide p28 conjugated to circumsporozoite protein provides protection against Plasmodium berghei SO VACCINE LA English DT Article DE molecular adjuvant; DNA vaccines; complement C3d ID MOLECULAR ADJUVANT; IMMUNE-RESPONSES; MALARIA; C3D AB Immune response against circumsporozoite protein (CSP) of Plasmodium berghei, a major surface protein on the sporozoite, confers protection in various murine malaria models. Engineered DNA vaccine encoding CSP and 3 copies of C3d caused an unexpected loss in protection attributed to the binding of C3d to the C-terminal region of CSP. Because the C3d region known as p28 represents the complement receptor (CR) 2-binding motif, we developed a CSP-3 copies of p28 DNA construct (CSP-3p28). CSP-3p28-immunized mice were better protected against P.berghei sporozoites than CSP-immunized mice 6 weeks after the 2nd boost, produced sufficient IgGl anti-CSP and CSP C-terminus antibody and failed to produce IgG2a. CSP-3C3d-immunized mice were not protected, failed to produce IgG l and produced high amounts of IgG2a. We conclude that use of the CR2-binding motif of C3d as molecular adjuvant to CSP results in anti-malaria protective immune response probably by targeting the chimeric protein to CR2. Published by Elsevier Ltd. C1 Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. NIH, Dermatol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20852 USA. Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA. RP Bergmann-Leitner, ES (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave,Room 3W65, Silver Spring, MD 20910 USA. EM elke.bergmannleitner@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011; Leitner, Wolfgang/F-5741-2011; OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Leitner, Wolfgang/0000-0003-3125-5922; Neutzner, Albert/0000-0001-9254-5558 FU NIAID NIH HHS [R03 AI053463] NR 7 TC 17 Z9 20 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 7 PY 2007 VL 25 IS 45 BP 7732 EP 7736 DI 10.1016/j.vaccine.2007.08.030 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 233PU UT WOS:000251103600004 PM 17931754 ER PT J AU Eller, MA Eller, LA Opollo, MS Ouma, BJ Oballah, PO Galley, L Karnasuta, C Kim, SR Robb, ML Michael, NL Kibuuka, H Wabwire-Mangen, F Graham, BS Birx, DL de Souza, MS Cox, JH AF Eller, Michael A. Eller, Leigh Anne Opollo, Marc S. Ouma, Benson J. Oballah, Peter O. Galley, Lynee Karnasuta, Chitraporn Kim, Silvia Ratto Robb, Merlin L. Michael, Nelson L. Kibuuka, Hannah Wabwire-Mangen, Fred Graham, Barney S. Birx, Deborah L. de Souza, Mark S. Cox, Josephine H. TI Induction of HIV-specific functional immune responses by a multiclade HIV-1 DNA vaccine candidate in healthy Ugandans SO VACCINE LA English DT Article DE DNA vaccine; HIV-1; CTL; LPA; ADCC ID T-CELL RESPONSES; IMMUNOGENICITY EVALUATION; CLINICAL-TRIALS; PHASE-1 SAFETY; SUBTYPE-B; VOLUNTEERS; DIVERSITY; VECTOR; ADULTS AB A phase I randomized, double blind, placebo-controlled trial to assess the immunogenicity of a multiclade HIV-1 DNA plasmid vaccine was conducted in 31 HIV-1-negative Ugandans. Following immunization with DNA at 0, 1, and 2 months, the frequency of HIV-specific immune responses was assessed up to 10 months using a standard chromium release assay (CRA), lymphoproliferative assay (LPA), and antibody dependent cell-mediated cytotoxicity assay (ADCC). Seven of 15 (47%) vaccinees demonstrated CTL activity using the CRA to HIV-1 Env B with responses observed 1 month following the second vaccination and as late as 7 months following complete immunization. Additionally, lymphoproliferative reponses were observed in 14/15 vaccinees against p24. No CTL or LPA responses were observed at baseline or in the placebo group. ADCC activity was minimally induced by DNA vaccination. This study demonstrates that immunization with DNA alone induces CTL and lymphoproliferative responses in a population that will participate in a phase IIb study evaluating HIV-1 DNA priming followed by boosting with a replication-defective recombinant adenovirus vector. (c) 2007 Elsevier Ltd. All rights reserved. C1 Makerere Univ, Walter Reed Project, Kampala, Uganda. Henry M Jackson Fdn, Rockville, MD USA. Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. NIH, Vaccine Res, Bethesda, MD 20892 USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Ctr Dis Control & Prevent, Atlanta, GA USA. RP Eller, MA (reprint author), Makerere Univ, Walter Reed Project, Kampala, Uganda. EM meller@muwrp.org OI waluyo, imam/0000-0002-1813-9487 NR 18 TC 19 Z9 19 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 7 PY 2007 VL 25 IS 45 BP 7737 EP 7742 DI 10.1016/j.vaccine.2007.08.056 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 233PU UT WOS:000251103600005 PM 17920731 ER PT J AU Carra, JH McHugh, CA Mulligan, S Machiesky, LM Soares, AS Millard, CB AF Carra, John H. McHugh, Colleen A. Mulligan, Sheila Machiesky, LeeAnn M. Soares, Alexei S. Millard, Charles B. TI Fragment-based identification of determinants of conformational and spectroscopic change at the ricin active site SO BMC STRUCTURAL BIOLOGY LA English DT Article ID CATION-PI INTERACTIONS; X-RAY-STRUCTURE; A-CHAIN; KINASE CSK; PROTEIN; UREA; BINDING; DENATURATION; INHIBITION; STABILITY AB Background: Ricin is a potent toxin and known bioterrorism threat with no available antidote. The ricin A-chain (RTA) acts enzymatically to cleave a specific adenine base from ribosomal RNA, thereby blocking translation. To understand better the relationship between ligand binding and RTA active site conformational change, we used a fragment-based approach to find a minimal set of bonding interactions able to induce rearrangements in critical side-chain positions. Results: We found that the smallest ligand stabilizing an open conformer of the RTA active site pocket was an amide group, bound weakly by only a few hydrogen bonds to the protein. Complexes with small amide-containing molecules also revealed a switch in geometry from a parallel towards a splayed arrangement of an arginine-tryptophan cation-pi interaction that was associated with an increase and red-shift in tryptophan fluorescence upon ligand binding. Using the observed fluorescence signal, we determined the thermodynamic changes of adenine binding to the RTA active site, as well as the site-specific binding of urea. Urea binding had a favorable enthalpy change and unfavorable entropy change, with a Delta H of - 13 +/- 2 kJ/mol and Delta S of -0.04 +/- 0.01 kJ/(K*mol). The side-chain position of residue Tyr80 in a complex with adenine was found not to involve as large an overlap of rings with the purine as previously considered, suggesting a smaller role for aromatic stacking at the RTA active site. Conclusion: We found that amide ligands can bind weakly but specifically to the ricin active site, producing significant shifts in positions of the critical active site residues Arg180 and Tyr80. These results indicate that fragment-based drug discovery methods are capable of identifying minimal bonding determinants of active-site side-chain rearrangements and the mechanistic origins of spectroscopic shifts. Our results suggest that tryptophan fluorescence provides a sensitive probe for the geometric relationship of arginine-tryptophan pairs, which often have significant roles in protein function. Using the unusual characteristics of the RTA system, we measured the still controversial thermodynamic changes of site-specific urea binding to a protein, results that are relevant to understanding the physical mechanisms of protein denaturation. C1 [Carra, John H.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [McHugh, Colleen A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. [Mulligan, Sheila] Mt St Marys Univ, Emmitsburg, MD 21727 USA. [Machiesky, LeeAnn M.] Goldbelt Raven LLC, Frederick, MD 21701 USA. [Soares, Alexei S.] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. [Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Carra, JH (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM john.carra@amedd.army.mil; cmchugh@amedd.army.mil; sheila.mulligan@amedd.army.mil; leanne.machiesky@amedd.army.mil; soares@bnl.gov; charles.millard@amedd.army.mil NR 46 TC 12 Z9 12 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2237 J9 BMC STRUCT BIOL JI BMC Struct. Biol. PD NOV 6 PY 2007 VL 7 AR 72 DI 10.1186/1472-6807-7-72 PG 11 WC Biophysics SC Biophysics GA 251HR UT WOS:000252364500001 PM 17986339 ER PT J AU Pan, E Sun, M Chung, PW Zhu, R AF Pan, E. Sun, M. Chung, P. W. Zhu, R. TI Three-dimensional kinetic Monte Carlo simulation of prepatterned quantum-dot island growth SO APPLIED PHYSICS LETTERS LA English DT Article ID SELF-ORGANIZED GROWTH; GAAS; SUPERLATTICES; SURFACES; ARRAYS AB A special prepatterning method is proposed for spatially ordered self-organizing quantum dots on anisotropic semiconductor substrates. Using three-dimensional kinetic Monte Carlo simulations, atoms are deposited with varying intermediate interruption times. We demonstrate the effect of interruption time and long-range anisotropic strain energy on island size uniformity and lateral alignment. C1 Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. Univ Akron, Dept Appl Math, Akron, OH 44325 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. ABS Amer, Offshore Engn Dept, Houston, TX 77060 USA. RP Pan, E (reprint author), Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. EM pan2@uakron.edu RI Pan, Ernian/F-4504-2011 OI Pan, Ernian/0000-0001-6640-7805 NR 33 TC 7 Z9 9 U1 2 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 5 PY 2007 VL 91 IS 19 AR 193110 DI 10.1063/1.2812572 PG 3 WC Physics, Applied SC Physics GA 229NH UT WOS:000250810300075 ER PT J AU Scafetta, N West, BJ AF Scafetta, N. West, B. J. TI Phenomenological reconstructions of the solar signature in the Northern Hemisphere surface temperature records since 1600 SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID CLIMATE-CHANGE; MAUNDER MINIMUM; EARTHS CLIMATE; UPPER OCEAN; IRRADIANCE; VARIABILITY; CYCLE; SENSITIVITY; CENTURIES; UNCERTAINTIES AB A phenomenological thermodynamic model is adopted to estimate the relative contribution of the solar-induced versus anthropogenic-added climate forcing during the industrial era. We compare different preindustrial temperature and solar data reconstruction scenarios since 1610. We argue that a realistic climate scenario is the one described by a large preindustrial secular variability ( as the one shown by the paleoclimate temperature reconstruction by Moberg et al. ( 2005)) with the total solar irradiance experiencing low secular variability ( as the one shown by Wang et al. ( 2005)). Under this scenario the Sun might have contributed up to approximately 50% ( or more if ACRIM total solar irradiance satellite composite ( Willson and Mordvinov, 2003) is implemented) of the observed global warming since 1900. C1 Duke Univ, Dept Phys, Durham, NC 27708 USA. USA, Math & Informat Sci Directorate, Res Off, Res Triangle Pk, NC 27709 USA. RP Scafetta, N (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA. EM ns2002@duke.edu RI West, Bruce/E-3944-2017; OI Scafetta, Nicola/0000-0003-0967-1911 NR 68 TC 47 Z9 49 U1 2 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD NOV 3 PY 2007 VL 112 IS D24 AR D24S03 DI 10.1029/2007JD008437 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 228CX UT WOS:000250705800001 ER PT J AU Mann, EA Pidcoke, HF Salinas, J Wade, CE Holcomb, JB Wolf, SE AF Mann, Elizabeth A. Pidcoke, Heather F. Salinas, Jose Wade, Charles E. Holcomb, John B. Wolf, Steven E. TI Accuracy of glucometers should not be assumed SO AMERICAN JOURNAL OF CRITICAL CARE LA English DT Letter ID CRITICALLY ILL PATIENTS; BLOOD-TRANSFUSION; CARE; ANEMIA C1 [Mann, Elizabeth A.; Pidcoke, Heather F.; Salinas, Jose; Wade, Charles E.; Holcomb, John B.; Wolf, Steven E.] USA, Inst Surg Res, San Antonio, TX 78249 USA. RP Mann, EA (reprint author), USA, Inst Surg Res, San Antonio, TX 78249 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 8 TC 9 Z9 9 U1 0 U2 3 PU AMER ASSOC CRITICAL CARE NURSES PI ALISO VIEJO PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA SN 1062-3264 J9 AM J CRIT CARE JI Am. J. Crit. Care PD NOV PY 2007 VL 16 IS 6 BP 531 EP 532 PG 2 WC Critical Care Medicine; Nursing SC General & Internal Medicine; Nursing GA 271TB UT WOS:000253810500003 PM 17962493 ER PT J AU Salerno, SM Carlson, DW Soh, EK Lettieri, CJ AF Salerno, Stephen M. Carlson, Daniel W. Soh, Eugene K. Lettieri, Christopher J. TI Letter SO AMERICAN JOURNAL OF MEDICINE LA English DT Letter C1 Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Salerno, SM (reprint author), Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9343 J9 AM J MED JI Am. J. Med. PD NOV PY 2007 VL 120 IS 11 BP E29 EP E29 DI 10.1016/j.amjmed.2007.06.025 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 226GO UT WOS:000250576100035 ER PT J AU Litz, BT Engel, CC Bryant, RA Papa, A AF Litz, Brett T. Engel, Charles C. Bryant, Richard A. Papa, Anthony TI A randomized, controlled proof-of-concept trial of an internet-based, therapist-assisted self-management treatment for posttraumatic stress disorder SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Article ID PSYCHOMETRIC PROPERTIES; PTSD; INTERVENTIONS AB Objective: The authors report an 8-week randomized, controlled proot-of-concept trial of a new therapist-assisted, Internetbased, selt-management cognitive behavior therapy versus Internet-based supportive counseling for posttraumatic stress disorder (PTSD). Method: Service members with PTSD from the attack on the Pentagon on September 11th or the Iraq War were randomly assigned to self-management cognitive behavior therapy (N = 24) or supportive counseling (N = 21). Results: The dropout rate was similar to regular cognitive behavior therapy (30%) and unrelated to treatment arm. In the intent-to-treat group, self-management cognitive behavior therapy led to sharper declines in daily log-on ratings of PTSD symptoms and global depression. In the completer group, self-management cognitive behavior therapy led to greater reductions in PTSD, depression, and anxiety scores at 6 months. one-third of those who completed self-management cognitive behavior therapy achieved high-end state functioning at 6 months. Conclusions: Self-management cognitive behavior therapy may be a way of delivering effective treatment to large numbers with unmet needs and barriers to care. C1 Boston Univ, Sch Med, Boston, MA 01230 USA. Natl Ctr PTSD Boston VA Healthcare Syst, Boston, MA USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Bethesda, MD USA. Univ New S Wales, Sydney, NSW, Australia. RP Litz, BT (reprint author), Boston Univ, Sch Med, 116-B5,150 S Huntington Ave, Boston, MA 01230 USA. EM brett.litz@va.gov OI Bryant, Richard/0000-0002-9607-819X FU NIMH NIH HHS [MH66589] NR 20 TC 131 Z9 140 U1 2 U2 20 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD NOV PY 2007 VL 164 IS 11 BP 1676 EP 1683 DI 10.1176/appi.ajp.2007.06122057 PG 8 WC Psychiatry SC Psychiatry GA 229NP UT WOS:000250811200013 PM 17974932 ER PT J AU O'Brien, SD Bui-Mansfield, LT AF O'Brien, Seth D. Bui-Mansfield, Liem T. TI MRI of quadratus femoris muscle tear: Another cause of hip pain SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE hip pain; MRI; muscle tear; quadratus femoris muscle ID STRAIN AB OBJECTIVE. The objective of this study is to report the MR appearance of quadratus femoris muscle tear, another cause of hip pain. We will review the pertinent anatomy of the quadratus femoris muscle, summarize the current literature on quadratus femoris muscle tear, and report our experience in the diagnosis of quadratus femoris muscle tear on MRI. CONCLUSION. MRI is an important tool in assisting clinicians to make a correct diagnosis for the patient who presents with hip pain. Although quadratus femoris muscle tear is an uncommon injury, radiologists should be aware of this entity to assist with making a diagnosis that is usually unsuspected clinically. C1 Brooke Army Med Ctr, SAUSHEC, Ft Sam Houston, TX 78234 USA. Wake Forest Univ, Dept Radiol, Winston Salem, NC 27157 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, SAUSHEC, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM liem.mansfield@gmail.com NR 6 TC 30 Z9 34 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD NOV PY 2007 VL 189 IS 5 BP 1185 EP 1189 DI 10.2214/AJR.07.2408 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 225LD UT WOS:000250518500028 PM 17954659 ER PT J AU Taylor, DC Tenuta, JJ Uhorchak, JM Arciero, RA AF Taylor, Dean C. Tenuta, Joachim J. Uhorchak, John M. Arciero, Robert A. TI Aggressive surgical treatment and early return to sports in athletes with grade III syndesmosis sprains SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE sprain; syndesmosis; ankle; internal fixation; athletes ID ANKLE SPRAINS; TIBIOFIBULAR SYNDESMOSIS; INJURY; FIXATION; FRACTURE; AREA AB Background: Grade III syndesmosis sprains are usually treated with internal fixation. Limited information is available on early weightbearing and early return to activity after operative treatment for grade III syndesmosis sprains. Hypothesis: Treatment of grade III syndesmosis sprains in intercollegiate athletes with internal fixation, early range of motion, and early weightbearing can lead to rapid return to sport with minimal complications and no ankle problems in midterm follow-up. Study Design: Case series; Level of evidence, 4. Methods: We evaluated a consecutive series of intercollegiate athletes treated operatively with 4.5-mm cortical screw fixation for grade III syndesmosis sprains. At 1 week after surgery, patients were allowed to begin range of motion exercises, progressive weightbearing, and gradually return to full activity as tolerated. Outcome measures included time to return to full activity and, at final follow-up, the Sports Ankle Rating System scores. Results: Six male intercollegiate college athletes met the inclusion criteria for this study. The average time for return to full activity was 41 days (range, 32-48 days). There were no intraoperative complications or complications when resuming in-season sport activities with the screw in place. One screw broke during removal. At an average follow-up of 34.3 months, using the Sports Ankle Rating System, the average clinical rating score was 96.2, the average quality-of-life measure was 96.7, and the average single assessment numeric evaluation was 95.3. Radiographs at final follow-up showed no mortise widening or lateral talar subluxation. Two patients had mild degenerative changes on lateral radiographs with anterior tibial osteophytes. Conclusions: In selective cases, athletes can return to full activity as early as 6 weeks after internal fixation of grade III syndesmosis sprains. C1 Duke Univ, Med Ctr, Div Orthopaed Surg, Dept Surg, Durham, NC 27710 USA. Keller Army Community Hosp, W Point Sports Med, West Point, NY USA. Univ Connecticut, Ctr Hlth, Farmington, CT USA. RP Taylor, DC (reprint author), Duke Univ, Med Ctr, Div Orthopaed Surg, Dept Surg, Box 3615, Durham, NC 27710 USA. NR 18 TC 15 Z9 19 U1 0 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD NOV PY 2007 VL 35 IS 11 BP 1833 EP 1838 DI 10.1177/0363546507304666 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 228GR UT WOS:000250718400005 PM 17644659 ER PT J AU Bui-Mansfield, LT Banks, KR Taylor, DC AF Bui-Mansfield, Liem T. Banks, Kevin R. Taylor, Dean C. TI Humeral avulsion of the glenohumeral ligaments SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE humeral avulsion of the glenohumeral ligament ID ANTERIOR SHOULDER INSTABILITY; MR ARTHROGRAPHY; DISLOCATION; LESION; JOINT; BANKART AB Background: Anterior instability of the shoulder is a frequently encountered clinical problem that is seen after avulsion of the capsulolabral complex from the glenoid rim (Bankart lesion). Recently, it has been determined that avulsion of the glenohumeral ligaments is an infrequent but important cause of recurrent instability after shoulder injury. Although the various forms of this injury have been described in the literature, no standardized nomenclature exists. This is of concern given the need for different surgical approaches to repair the various forms of this injury and therefore the inherent need to accurately convey the location of the avulsion and presence of concomitant injuries. Hypothesis: Based on the available literature for humeral avulsion of the glenohumeral ligament lesions, a nomenclature can be created to enhance the understanding and improve communication about these uncommon but important pathologic changes that occur with shoulder instability. Study Design: Systematic review. Methods: The findings pertaining to 6 patients with humeral avulsion of the glenohumeral ligament lesions encountered at our institution were combined with a literature search of the MEDLINE database conducted using the PubMed search engine of the National Library of Medicine and National Center for Biotechnology Information. Results: The West Point nomenclature was developed to clearly describe the various forms of humeral avulsion of the glenohumeral ligament lesions encountered as well as their associated injuries. Conclusions: The West Point nomenclature provides a practical and easy to understand means by which to classify humeral avulsion of the glenohumeral ligament lesions. This allows for more effective communication, which should result in improved clinical care. C1 Brooke Army Med Ctr, Dept Radiol, MCHE DR, Ft Sam Houston, TX 78234 USA. Wake Forest Univ, Sch Med, Div Radiol Sci, Dept Radiol, Winston Salem, NC 27109 USA. Duke Univ, Med Ctr, Durham, NC USA. RP Bui-Mansfield, LT (reprint author), 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM liem.mansfield@amedd.army.mil NR 18 TC 34 Z9 34 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD NOV PY 2007 VL 35 IS 11 BP 1960 EP 1966 DI 10.1177/0363546507301081 PG 7 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 228GR UT WOS:000250718400023 PM 17420506 ER PT J AU Noisakran, S Gibbons, R Songprakhon, P Jairungsri, A Ajariyakhajorn, C Nisalak, A Jarman, R Mammen, M Chokephaibulkit, K Malasit, P Perng, G AF Noisakran, Sansanee Gibbons, Robert Songprakhon, Pucharee Jairungsri, Aroonroong Ajariyakhajorn, Chuanpis Nisalak, Ananda Jarman, Richard Mammen, Mammen Chokephaibulkit, Kulkanya Malasit, Prida Perng, Guey TI Higher frequency of dengue viral RNA detected in platelets than in plasma in the late stage of dengue virus infection SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Noisakran, Sansanee; Songprakhon, Pucharee; Jairungsri, Aroonroong; Chokephaibulkit, Kulkanya; Malasit, Prida] Siriraj Hosp, Off Res & Dev, Med Mol Biol Unit, Bangkok, Thailand. [Gibbons, Robert; Ajariyakhajorn, Chuanpis; Nisalak, Ananda; Jarman, Richard; Mammen, Mammen; Perng, Guey] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RI Noisakran, Sansanee/H-5186-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 2 BP 1 EP 1 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200002 ER PT J AU Angov, E Bergmann-Leitner, ES Duncan, EH Brent-Kirk, A McCasland, M Mease, R Soisson, LS Demoitie, MA Ogutu, B Heppner, DG Lyon, JA AF Angov, Evelina Bergmann-Leitner, Elke S. Duncan, Elizabeth H. Brent-Kirk, Afiya McCasland, Michael Mease, Ryan Soisson, Lorraine S. Demoitie, Marie-Ange Ogutu, Bernhards Heppner, D. Gray Lyon, Jeffrey A. TI Measurement of antibody fine specificities induced by malaria vaccine FMP1/AS02A from a pediatric phase 2b trial in Western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Angov, Evelina; Bergmann-Leitner, Elke S.; Duncan, Elizabeth H.; Brent-Kirk, Afiya; McCasland, Michael; Mease, Ryan; Heppner, D. Gray; Lyon, Jeffrey A.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Soisson, Lorraine S.] US Agcy Int Dev, Washington, DC USA. [Demoitie, Marie-Ange] GlaxoSmithKline Biol, Rixensart, Belgium. [Ogutu, Bernhards] Kenya Govt Med Res Ctr, Kisumu, Kenya. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 12 BP 4 EP 4 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200013 ER PT J AU Stewart, VA McGrath, SM Pau, MG Mettens, P Dubois, PM Shott, J Demoitie, MA Custers, JH Weverling, GJ Bayat, B Donner, MN Dubois, MC Cohen, J Goudsmit, J Heppner, DG AF Stewart, V. Ann McGrath, Shannon M. Pau, Maria Grazia Mettens, Pascal Dubois, Patrice M. Shott, Joseph Demoitie, Maria-Ange Custers, Jerome H. H. V. Weverling, Gerrit-Jan Bayat, Babak Donner, Marie-Noelle Dubois, Marie-Claude Cohen, Joe Goudsmit, Jaap Heppner, D. Gray TI Comparison of the immunogenicity of adenovirus 35-PFCS alone and in heterologous combination with an adenovirus 5-PFCS construct SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Stewart, V. Ann; McGrath, Shannon M.; Shott, Joseph; Heppner, D. Gray] Walter Reed Army Inst Res, Silver Spring, MD USA. [Pau, Maria Grazia; Custers, Jerome H. H. V.; Weverling, Gerrit-Jan; Goudsmit, Jaap] Crucell Holland BV, Leiden, Netherlands. [Mettens, Pascal; Demoitie, Maria-Ange; Bayat, Babak; Donner, Marie-Noelle; Dubois, Marie-Claude; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Dubois, Patrice M.] ImmunoVacc Consulting, Brussels, Belgium. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 44 BP 13 EP 14 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200045 ER PT J AU Kaba, SA Brando, C Tropel, D Burkhard, P Lanar, D AF Kaba, Stephen A. Brando, Clara Tropel, David Burkhard, Peter Lanar, David TI A non-adjuvanted self-assembling polypeptide nanoparticle (SAPN) malaria vaccine confers sterile protection to lethal sporozoite challenge SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Kaba, Stephen A.; Brando, Clara; Lanar, David] Walter Reed Army Inst Res, Silver Spring, MD USA. [Tropel, David] ME Mueller Inst Struct Biol, Basel, Switzerland. [Burkhard, Peter] Alpha O Peptides, Allschwil, Switzerland. RI Kaba, Stephen/B-3555-2011; Lanar, David/B-3560-2011 OI Kaba, Stephen/0000-0003-1509-2975; NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 45 BP 14 EP 14 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200046 ER PT J AU Bhattacharjee, AK Chauhan, KR Bathini, N Greico, J Achee, N Lawrence, K Benante, JP Gupta, RK AF Bhattacharjee, Apurba K. Chauhan, Kamalesh R. Bathini, Nagendrababu Greico, John Achee, Nicole Lawrence, Kendra Benante, John Paul Gupta, Raj K. TI Analysis of In silico stereoelectronic properties of PMD (P-menthane-3-8-diols) and its derivatives to develop a pharmacophore for insect repellent activity SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Bhattacharjee, Apurba K.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Chauhan, Kamalesh R.; Bathini, Nagendrababu] Agr Res Ctr Chem Affecting Insect Behav Lab, USDA, Beltsville, MD USA. [Greico, John; Achee, Nicole] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Lawrence, Kendra; Benante, John Paul] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Gupta, Raj K.] Walter Reed Army Inst Res, Off Sci Director, Silver Spring, MD USA. RI Bathini, Nagendra Babu/E-4666-2010 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 63 BP 19 EP 19 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200064 ER PT J AU Pallys, TJ Scovill, J Hoke, CH Abrams, J Hanson, K Clark, K Kitchen, LW Vaughn, DW Burnette, WN AF Pallys, Tom J. Scovill, John Hoke, Charles H. Abrams, Jerry Hanson, Kevin Clark, Kathryn Kitchen, Lynn W. Vaughn, David W. Burnette, W. Neal TI A quantitative algorithm for prioritization of naturally occurring infectious disease threats to the US military SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Pallys, Tom J.; Kitchen, Lynn W.; Vaughn, David W.] Mil Infect Dis Res Program, USA, Ft Detrick, MD USA. [Scovill, John; Abrams, Jerry] Sci Applicat Int Corp, Mclean, VA USA. [Hoke, Charles H.] Anteon Corp, Fairfax, VA USA. [Hanson, Kevin; Clark, Kathryn] Armed Forces Med Intelligence Ctr, Ft Detrick, MD USA. [Burnette, W. Neal] Mol Pharmaceut Corp, Westlake Village, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 102 BP 30 EP 30 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200103 ER PT J AU Dorji, T Yoon, IK Nisalak, A Jarman, R Myint, KS Gibbons, RV AF Dorji, Tandin Yoon, In-Kyu Nisalak, Ananda Jarman, Richard Myint, Khin S. Gibbons, Robert V. TI Dengue infection in Bhutan SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Dorji, Tandin] Dept Publ Hlth, Thimphu, Bhutan. [Yoon, In-Kyu; Nisalak, Ananda; Jarman, Richard; Myint, Khin S.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 113 BP 33 EP 34 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200114 ER PT J AU Whitehouse, C Turell, MJ Butler, A Baldwin, C Hottel, H Mores, C AF Whitehouse, Chris Turell, Michael J. Butler, Ashley Baldwin, Carson Hottel, Hannah Mores, Christopher TI Assay for and replication of Karshi (mammalian tick-borne Flavivirus group) virus in mice SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Whitehouse, Chris; Turell, Michael J.; Butler, Ashley; Baldwin, Carson; Hottel, Hannah] USA, Med Res Inst Infect Dis, Ft Detrick, MD USA. [Mores, Christopher] Florida Med Entomol Lab, Vero Beach, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 125 BP 37 EP 37 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200126 ER PT J AU Nicoll, WS Sacci, JB Rodolfo, C DiGiacomo, G Piacentini, M Hollingdale, MR Lanar, DE AF Nicoll, William S. Sacci, John B. Rodolfo, Carlo DiGiacomo, Giuseppina Piacentini, Mauro Hollingdale, Michael R. Lanar, David E. TI Plasmodium falciparum liver stage Antigen-1 is crosslinked by tissue transglutaminase SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Nicoll, William S.; Sacci, John B.; Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sacci, John B.] Univ Maryland, Sch Med, Baltimore, MD USA. [DiGiacomo, Giuseppina; Piacentini, Mauro] Univ Roma Tor Vergata, Rome, Italy. [Hollingdale, Michael R.] Natl Inst Hlth, Rockville, MD USA. RI Lanar, David/B-3560-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 158 BP 46 EP 46 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200158 ER PT J AU Bergmann-Leitner, ES Duncan, EH Angov, E AF Bergmann-Leitner, Elke S. Duncan, Elizabeth H. Angov, Evelina TI Multi-faceted impact of MSP-1P42 specific antibodies on blood stages of Plasmodium falciparum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Bergmann-Leitner, Elke S.; Duncan, Elizabeth H.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 161 BP 47 EP 47 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200161 ER PT J AU Li, Q Xie, L Zhang, J Weina, P AF Li, Qigui Xie, Lisa Zhang, Jing Weina, Peter TI Pharmacokinetic comparison of artesunate (AS) following multiple intravenous injections in the Plasmodium berghei infected and uninfected rats SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Li, Qigui; Xie, Lisa; Zhang, Jing; Weina, Peter] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 167 BP 48 EP 49 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200167 ER PT J AU Li, Q Si, Y Smith, K Zeng, Q Weina, P AF Li, Qigui Si, Yuanzheng Smith, Kirsten Zeng, Qiang Weina, Peter TI Pharmacokinetic profiles of injectable artesunate (AS) in the pregnant and non-pregnant rats in relation to its embryotoxicity SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Li, Qigui; Si, Yuanzheng; Smith, Kirsten; Zeng, Qiang; Weina, Peter] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 168 BP 49 EP 49 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200168 ER PT J AU Xie, L Li, Q Zhang, J Weina, P AF Xie, Lisa Li, Qigui Zhang, Jing Weina, Peter TI Efficacy, toxicity and therapeutic indices of artesunate (AS) and dihydroartemisinin (DHA) in Plasmodium berghei infected and uninfected rats SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Xie, Lisa; Li, Qigui; Zhang, Jing; Weina, Peter] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 169 BP 49 EP 49 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200169 ER PT J AU Zhang, J Xie, L Gerena, L Weina, P Li, Q AF Zhang, Jing Xie, Lisa Gerena, Lucia Weina, Peter Li, Qigui TI Efficacy evaluations of 13 metabolites of artesunate in culture with various clones and isolates of Plasmodium falciparum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Zhang, Jing; Xie, Lisa; Gerena, Lucia; Weina, Peter; Li, Qigui] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 170 BP 49 EP 49 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200170 ER PT J AU Schiehser, GA Terpinski, J Ager, AI Magill, AJ Milhous, WK Ohrt, C Saunders, DL Kyle, DE Edstein, MD Rieckmann, KH Shanks, GD Sibley, CH Canfield, CJ Jacobus, LR Jacobus, DR AF Schiehser, Guy A. Terpinski, Jacek Ager, Arba I. Magill, Alan J. Milhous, Wil K. Ohrt, Colin Saunders, David L. Kyle, Dennis E. Edstein, Michael D. Rieckmann, Karl H. Shanks, G. Dennis Sibley, Carol H. Canfield, Craig J. Jacobus, Laura R. Jacobus, David R. TI Pre-clinical monkey toxicity study of jpc-2056-I, a third generation antifolate SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Schiehser, Guy A.; Terpinski, Jacek; Jacobus, Laura R.; Jacobus, David R.] Jacobus Pharmaceut Co Inc, Princeton, NJ USA. [Ager, Arba I.] Univ Miami, Sch Med, Miami, FL USA. [Magill, Alan J.; Milhous, Wil K.; Ohrt, Colin; Saunders, David L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kyle, Dennis E.] Univ S Florida, Tampa, FL USA. [Edstein, Michael D.; Rieckmann, Karl H.; Shanks, G. Dennis] Australian Army Malaria Inst, Enoggera, Qld, Australia. [Sibley, Carol H.] Univ Washington, Seattle, WA USA. [Canfield, Craig J.] Pharmaceut Syst Inc, Talent, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 173 BP 50 EP 50 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200173 ER PT J AU Schiehser, GA Terpinski, J Ager, AL Magill, AJ Milhous, WK Ohrt, C Saunders, DL Kyle, DE Edstein, MD Rieckmann, KH Shanks, GD Sibley, CH Canfield, CJ Jacobus, LR Jacobus, DF AF Schiehser, Guy A. Terpinski, Jacek Ager, Arba L. Magill, Alan J. Milhous, Wil K. Ohrt, Colin Saunders, David L. Kyle, Dennis E. Edstein, Michael D. Rieckmann, Karl H. Shanks, G. Dennis Sibley, Carol H. Canfield, Craig J. Jacobus, Laura R. Jacobus, David F. TI Pre-clinical mouse toxicity study of JPC-2056-I, a third generation antifolate antimalarial SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Schiehser, Guy A.; Terpinski, Jacek; Jacobus, Laura R.; Jacobus, David F.] Jacobus Pharmaceut Co Inc, Princeton, NJ USA. [Ager, Arba L.] Univ Miami, Sch Med, Miami, FL USA. [Magill, Alan J.; Milhous, Wil K.; Ohrt, Colin; Saunders, David L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kyle, Dennis E.] Univ S Florida, Tampa, FL USA. [Edstein, Michael D.; Rieckmann, Karl H.; Shanks, G. Dennis] Australian Army Malaria Inst, Enoggera, Qld, Australia. [Sibley, Carol H.] Univ Washington, Seattle, WA USA. [Canfield, Craig J.] Pharmaceut Syst Inc, Talent, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 174 BP 50 EP 50 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200174 ER PT J AU Kiang, R Adimi, F Zollner, G Coleman, R AF Kiang, Richard Adimi, Farida Zollner, Gabriela Coleman, Russell TI Simulation of malaria transmission among households in a Thailand village using remotely sensed parameters SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Kiang, Richard; Adimi, Farida] NASA, Goddard Space Flight Ctr, Greenbelt, MD USA. [Zollner, Gabriela; Coleman, Russell] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 185 BP 54 EP 54 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200185 ER PT J AU Siu, E Ebringer, A Baker, J Auliff, A Kendino, G Staley, J Davis, D Chen, N Gregory, R Rieckmann, K Lilley, K Shanks, GD Cheng, Q O'Neill, MT AF Siu, Edwin Ebringer, Andrew Baker, Joanne Auliff, Alyson Kendino, Gideon Staley, John Davis, Derek Chen, Nanhua Gregory, Robin Rieckmann, Karl Lilley, Ken Shanks, G. Dennis Cheng, Qin O'Neill, Michael T. TI High prevalence of asymptomatic malaria infections in the Papua New Guinea Defence Force SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Siu, Edwin] Univ Queensland, Brisbane, Qld, Australia. [Ebringer, Andrew; Baker, Joanne; Auliff, Alyson; Staley, John; Davis, Derek; Chen, Nanhua; Rieckmann, Karl; Lilley, Ken; Shanks, G. Dennis; Cheng, Qin] Australian Army Malaria Inst, Enoggera, Qld, Australia. [Kendino, Gideon] Papua New Guinea Defence Force, Port Moresby, Papua N Guinea. [O'Neill, Michael T.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 187 BP 54 EP 54 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200187 ER PT J AU Mease, R Duncan, EH Waitumbi, J Mann-Leitner, EB Angov, E AF Mease, Ryan Duncan, Elizabeth H. Waitumbi, John Mann-Leitner, Elke Berg Angov, Evelina TI Evaluation of immunoglobulin purification methods and their effects on IGS antibody specificity SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Mease, Ryan; Duncan, Elizabeth H.; Mann-Leitner, Elke Berg; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Waitumbi, John] Kenya Govt Med Res Ctr, Kisumu, Kenya. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 215 BP 62 EP 63 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200215 ER PT J AU House, BL Zou, X Aguiar, JC De la Vega, P Richie, TL AF House, Brent L. Zou, Xiaoyan Aguiar, Joao C. De la Vega, Patricia Richie, Thomas L. TI Development and optimization of a Plasmodium falciparum inhibition of sporozoite invasion (ISI) assay SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [House, Brent L.; Zou, Xiaoyan; Aguiar, Joao C.; Richie, Thomas L.] Naval Med Res Ctr, Silver Spring, MD USA. [De la Vega, Patricia] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Zou, Xiaoyan/E-5564-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 217 BP 63 EP 63 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200217 ER PT J AU Pichyangkul, S Kum-Arb, U Yongvanitchit, K Limsalakpetch, A Gettayacamin, M Lanar, DE Ware, LA Stewart, VA Heppner, DG Mettens, P Cohen, JD Ballou, WR Fukuda, MM AF Pichyangkul, Sathit Kum-Arb, Utaiwan Yongvanitchit, Kosol Limsalakpetch, Amporn Gettayacamin, Monthip Lanar, David E. Ware, Lisa A. Stewart, V. A. Heppner, D. Gray Mettens, Pascal Cohen, Joe D. Ballou, W. R. Fukuda, Mark M. TI Pre-clinical evaluation of safety and immunogenicity of Plasmodium falciparum LSA1/AS01B when administered separately or concurrently with RTS,S/AS01B in rhesus primates SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Pichyangkul, Sathit; Kum-Arb, Utaiwan; Yongvanitchit, Kosol; Limsalakpetch, Amporn; Gettayacamin, Monthip; Fukuda, Mark M.] USA, Med Component Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Lanar, David E.; Ware, Lisa A.; Stewart, V. A.; Heppner, D. Gray] Walter Reed Army Inst Res, Silver Spring, MD USA. [Mettens, Pascal; Cohen, Joe D.; Ballou, W. R.] GlaxoSmithKline Biol, Rixensart, Belgium. RI Lanar, David/B-3560-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 218 BP 63 EP 64 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200218 ER PT J AU Bergman-Leitner, ES Duncan, EH Spring, MD Angov, E AF Bergman-Leitner, Elke S. Duncan, Elizabeth H. Spring, Michele D. Angov, Evelina TI Miniaturized high throughput PLDH-based Plasmodium falciparum growth inhibition assay for low volume samples SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Bergman-Leitner, Elke S.; Duncan, Elizabeth H.; Spring, Michele D.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 220 BP 64 EP 64 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200220 ER PT J AU McCasland, M Brent-Kirk, A Soisson, L Stoute, JA Ockenhouse, CF Waitumbi, J Ogutu, B Angov, E AF McCasland, Michael Brent-Kirk, Afiya Soisson, Lorraine Stoute, Jose A. Ockenhouse, Christian F. Waitumbi, John Ogutu, Bernhards Angov, Evelina TI Detecting antibody fine specificities to Plasmodium falciparum MSP1 subunits by particle based flow cytometry in naive and malaria experienced populations vaccinated with FMP1/AS02A SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [McCasland, Michael; Brent-Kirk, Afiya; Stoute, Jose A.; Ockenhouse, Christian F.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Soisson, Lorraine] US Agcy Int Dev, Washington, DC USA. [Waitumbi, John; Ogutu, Bernhards] Kenya Govt Med Res Ctr, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 219 BP 64 EP 64 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200219 ER PT J AU Piriou, E Chelimo, K Kimmel, R Dutta, S Long, C Lanar, DE Middeldorp, JM Moormann, AM Rochford, R AF Piriou, Erwan Chelimo, Kiprotich Kimmel, Rhonda Dutta, Sheetij Long, Carole Lanar, David E. Middeldorp, Jaap M. Moormann, Ann M. Rochford, Rosemary TI Multiplexed measurement of epstein barr virus, cytomegalovirus and Plasmodium falciparum-specific antibodies using the luminex system SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Piriou, Erwan; Chelimo, Kiprotich] Kenya Govt Med Res Ctr, Ctr Vector Biol & Control Res, Kisumu, Kenya. [Kimmel, Rhonda; Moormann, Ann M.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Dutta, Sheetij; Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Long, Carole] NIH, NIAID, Rockville, MD USA. [Middeldorp, Jaap M.] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands. [Rochford, Rosemary] SUNY Upstate Med Univ, Syracuse, NY USA. RI Lanar, David/B-3560-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 303 BP 86 EP 86 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200302 ER PT J AU Ghosh, K Braig, HR Lawyer, P Weina, P Rowton, E AF Ghosh, Kashinath Braig, Henk R. Lawyer, Phil Weina, Peter Rowton, Edgar TI Molecular identification of the gregarines of phlebotomine sand flies SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Ghosh, Kashinath; Lawyer, Phil; Weina, Peter; Rowton, Edgar] Walter Reed Army Inst Res, Silver Spring, MD USA. [Braig, Henk R.] Univ Wales, Bangor, Gwynedd, Wales. RI Weina, Peter/A-2120-2011; Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 318 BP 90 EP 90 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200317 ER PT J AU Jobe, O Lumsden, J Schwenk, RJ Williams, J Kappe, S Matuschewski, K Krzych, U AF Jobe, Ousman Lumsden, Joanne Schwenk, Robert J. Williams, Jackie Kappe, Stefan Matuschewski, Kai Krzych, Urszula TI Genetically-attenuated Plasmodium berghei liver-stages induce sterile protracted protection that is mediated by MHC class I-dependent IFN-gamma producing CD8+ T cells SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Jobe, Ousman; Lumsden, Joanne; Schwenk, Robert J.; Williams, Jackie; Krzych, Urszula] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kappe, Stefan] SBRI, Seattle, WA USA. [Matuschewski, Kai] Univ Heidelberg, Heidelberg, Germany. RI Lumsden, Joanne/B-6475-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 319 BP 90 EP 90 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200318 ER PT J AU Marovich, M AF Marovich, Mary TI Comparison of immune responses during leishmaniasis therapy SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Marovich, Mary] Walter Reed Army Inst Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 317 BP 90 EP 90 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200316 ER PT J AU Kosoy, M Bai, Y Morway, C Sheff, K Peruski, L Baggett, H Maloney, S Sutthirattana, S Dowell, S Sitdhirasd, A Lerdthusnee, K Murphy, J AF Kosoy, Michael Bai, Ying Morway, Christina Sheff, Kelly Peruski, Leonard Baggett, Henry Maloney, Susan Sutthirattana, Saithip Dowell, Scott Sitdhirasd, Anussorn Lerdthusnee, Kriangkrai Murphy, Jittawadee TI Identification of animal sources of human bartonellosis in Thailand: Comparison of Bartonella sequences from human patients and rodent hosts SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Kosoy, Michael; Bai, Ying; Morway, Christina; Sheff, Kelly] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Peruski, Leonard; Baggett, Henry; Maloney, Susan; Sutthirattana, Saithip] Int Emerging Infect Program, Nonthaburi, Thailand. [Dowell, Scott] Ctr Dis Control & Prevent, Atlanta, GA USA. [Sitdhirasd, Anussorn] Minist Publ Hlth, Bangkok, Thailand. [Lerdthusnee, Kriangkrai; Murphy, Jittawadee] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 330 BP 94 EP 94 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200329 ER PT J AU Simmons, M Ward, M Porter, K Hayes, C Sun, W Putnak, R AF Simmons, Monika Ward, Michelle Porter, Kevin Hayes, Curtis Sun, Wellington Putnak, Robert TI Improved immunogenicity and protection of tetravalent dengue vaccines using a prime-boost strategy in non-human primates SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Simmons, Monika; Ward, Michelle; Porter, Kevin; Hayes, Curtis] Naval Med Res Ctr, Silver Spring, MD USA. [Sun, Wellington] Ctr Dis Control & Prevent, San Juan, PR USA. [Putnak, Robert] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 346 BP 99 EP 99 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200345 ER PT J AU Dow, GS Magill, A Milhous, W Ohrt, C AF Dow, Geoffrey S. Magill, Alan Milhous, Wil Ohrt, Colin TI Clinical development of new prophylactic antimalarial drugs after the 5(TH) amendment to the declaration of helsinki SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Dow, Geoffrey S.; Magill, Alan; Milhous, Wil; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 357 BP 103 EP 103 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200356 ER PT J AU Aronson, NE Wortmann, G Rhorer, J Verter, J Shoemaker, D Hawkes, C AF Aronson, Naomi E. Wortmann, Glenn Rhorer, Janelle Verter, Joel Shoemaker, David Hawkes, Clifton CA Walter Reed Clin Leishmaniasis Grp TI What baseline patient characteristics predict toxicity during sodium stibogluconate treatment? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Aronson, Naomi E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Wortmann, Glenn; Hawkes, Clifton; Walter Reed Clin Leishmaniasis Grp] Walter Reed Army Med Ctr, Washington, DC USA. [Rhorer, Janelle; Verter, Joel] Stat Collaborat, Washington, DC USA. [Shoemaker, David] USA, Med Res Inst Infect Dis, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 379 BP 109 EP 109 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200378 ER PT J AU Mukbell, RM Wortmann, G Lesho, E Tripathi, V Wadsworth, M Stayback, G Oliveira, F Kamhawi, S Valenzuela, J Ramalho-Ortigao, M McDowell, MA AF Mukbell, Rami M. Wortmann, Glenn Lesho, Emil Tripathi, Vinita Wadsworth, Marina Stayback, Gwen Oliveira, Fabiano Kamhawi, Shaden Valenzuela, Jesus Ramalho-Ortigao, Marcelo McDowell, Mary Ann TI Human immune responses against Phlebotomus papatasi saliva SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Mukbell, Rami M.; Tripathi, Vinita; Wadsworth, Marina; Stayback, Gwen; Ramalho-Ortigao, Marcelo; McDowell, Mary Ann] Univ Notre Dame, Notre Dame, IN 46556 USA. [Wortmann, Glenn; Lesho, Emil] Walter Reed Army Med Ctr, Washington, DC USA. [Oliveira, Fabiano; Kamhawi, Shaden; Valenzuela, Jesus] Natl Inst Hlth, Rockville, MD USA. RI Ramalho-Ortigao, Marcelo/E-8225-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 395 BP 114 EP 114 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200394 ER PT J AU Zollner, G Hoell, D Hanafi, HA Richardson, JH Mukabana, R Coleman, RE AF Zollner, Gabriela Hoell, David Hanafi, Hanafi A. Richardson, Jason H. Mukabana, Richard Coleman, Russell E. TI Evaluation of novel long-lasting, insecticide-impregnated bed nets to control adult sand flies (Diptera : Phlebotominae) in human landing studies in Kenya and Egypt SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Zollner, Gabriela; Coleman, Russell E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Hoell, David; Hanafi, Hanafi A.] US Naval Med Res Unit No 3, Cairo, Egypt. [Mukabana, Richard] USA Med Res Unit, Nairobi, Kenya. RI Zollner, Gabriela/B-6073-2011; Richardson, Jason/A-9441-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 401 BP 116 EP 116 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200400 ER PT J AU Gerena, L Shusko, M Krulak, D Favata, M Neil, DA Chretien, JP MacIntosh, V Saunders, DL Magill, AJ Weina, PJ Milhous, WK AF Gerena, Lucia Shusko, Michael Krulak, David Favata, Mike Neil, Donald A. Chretien, Jean-Paul MacIntosh, Victor Saunders, David L. Magill, Alan J. Weina, Peter J. Milhous, Wilbur K. TI Doxycyline noncompliance results in severe and complicated falciparum malaria imported from Chad SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Gerena, Lucia; Saunders, David L.; Magill, Alan J.; Weina, Peter J.; Milhous, Wilbur K.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Shusko, Michael] Grp Surg Marine Special Operat Advisor Grp, Camp Lejeune, NC USA. [Krulak, David] Marine Special Operat Support Grp, Grp Surg, Camp Lejeune, NC USA. [Favata, Mike] Naval Hosp, Camp Lejeune, NC USA. [Neil, Donald A.] Dis Intervent & Prevent Specialist Dept Head P, Camp Lejeune, NC USA. [Chretien, Jean-Paul; MacIntosh, Victor] DoD Global Emerging Infect Surveillance & R, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 415 BP 119 EP 120 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200414 ER PT J AU Myint, KS Murray, CK Scott, RM Shrestha, MP Mammen, MP Thapa, GB Shrestha, SK Kuschner, RA Joshi, DM Gibbons, RV AF Myint, Khin S. Murray, Clinton K. Scott, Robert McNair Shrestha, Mrigendra P. Mammen, P. Mammen Thapa, Gyan B. Shrestha, Sanjaya K. Kuschner, Robert A. Joshi, Durga M. Gibbons, Robert V. TI Leptospirosis in Nepal SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Myint, Khin S.; Mammen, P. Mammen; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Scott, Robert McNair; Shrestha, Mrigendra P.; Shrestha, Sanjaya K.] Walter Reed Armed Forces Res Inst, Med Sci Res Unit, Kathmandu, Nepal. [Thapa, Gyan B.; Joshi, Durga M.] Nepalese Army, Kathmandu, Nepal. [Kuschner, Robert A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 2 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 430 BP 124 EP 124 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200428 ER PT J AU Stromdahl, EY Vince, M Evans, S AF Stromdahl, Ellen Y. Vince, Mary Evans, Sandra TI Ten years of ticks submitted to the human tick test kit program of the US Army center for health promotion and preventive medicine SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Stromdahl, Ellen Y.; Vince, Mary; Evans, Sandra] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 435 BP 125 EP 125 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200434 ER PT J AU Hickey, PW Palmer, DR Lynch, JA AF Hickey, Patrick W. Palmer, Dupeh R. Lynch, Julia A. TI Interferon-alpha immune modulation in a dendritic cell - T lymphocyte model of severe dengue disease SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Hickey, Patrick W.; Palmer, Dupeh R.; Lynch, Julia A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 445 BP 128 EP 128 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200444 ER PT J AU Pal, S McAvin, J Ekanayake, S Coleman, R Swaby, J Kochel, T Hayes, C Porter, K Wu, SJ AF Pal, Subhamoy McAvin, James Ekanayake, Sajeewane Coleman, Russell Swaby, James Kochel, Tadeusz Hayes, Curtis Porter, Kevin Wu, Shuenn-Jue TI Evaluation of a dual-use, field-deployable, dry-format, quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assay for detection of dengue virus in mosquitoes and humans SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Pal, Subhamoy; Ekanayake, Sajeewane; Hayes, Curtis; Wu, Shuenn-Jue] Naval Med Res Ctr, Silver Spring, MD USA. [McAvin, James; Swaby, James] CRES IMSR 59, Div Clin Res, Lackland AFB, TX USA. [Coleman, Russell] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Kochel, Tadeusz; Porter, Kevin] Naval Med Res Ctr Detachment, Lima, Peru. RI Pal, Subhamoy/A-8025-2011; Pal, Subhamoy/A-9526-2015 OI Pal, Subhamoy/0000-0003-0133-8444 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 444 BP 128 EP 128 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200443 ER PT J AU Potts, JA Kalayanarooj, S Nimmannitya, S Srikiatkhachorn, A Nisalak, A Vaughn, DW Li, W Green, S Rothman, AL AF Potts, James A. Kalayanarooj, Siripen Nimmannitya, Suchitra Srikiatkhachorn, Anon Nisalak, Ananda Vaughn, David W. Li, Wenjun Green, Sharone Rothman, Alan L. TI Analysis of agreement between individual and combined clinical and laboratory findings and an expert physician's diagnosis of dengue hemorrhagic fever SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Potts, James A.] Univ Massachusetts, Sch Med, Clin & Populat Hlth Res Div, Worcester, MA 01605 USA. [Kalayanarooj, Siripen; Nimmannitya, Suchitra] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Srikiatkhachorn, Anon; Green, Sharone; Rothman, Alan L.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01605 USA. [Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Vaughn, David W.] US Army Med Res & Mat Command, Ft Detrick, MD USA. [Li, Wenjun] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 453 BP 130 EP 130 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200451 ER PT J AU Mendez, J Ghosh, K Weina, PJ AF Mendez, Juan Ghosh, Kashinath Weina, Peter J. TI Rapid diagnosis of human leishmaniasis species using a rapid cellulose acetate electrophoresis (CAE) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Mendez, Juan; Ghosh, Kashinath; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 480 BP 138 EP 138 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200478 ER PT J AU Dave, K Chan, AS Smith, D Dave, S Brasov, L Coleman, RE Rowton, ED AF Dave, Kirti Chan, Adeline S. Smith, Derek Dave, Sonia Brasov, Loana Coleman, Russell E. Rowton, Edgar D. TI Development of a field-usable assay for detection of Leishmania parasites in sand flies SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Dave, Kirti; Dave, Sonia] VecTOR Test Syst Inc, Thousand Oaks, CA USA. [Chan, Adeline S.; Smith, Derek; Coleman, Russell E.; Rowton, Edgar D.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 483 BP 139 EP 139 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200481 ER PT J AU Takeo, S Hisamori, D Matsuda, S Vinetz, J Sattabongkot, J Tsuboi, T AF Takeo, Satoru Hisamori, Daisuke Matsuda, Shusaku Vinetz, Joseph Sattabongkot, Jetsumon Tsuboi, Takafumi TI Chitinase: Active recombinant protein from Plasmodium vivax SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Takeo, Satoru; Hisamori, Daisuke; Matsuda, Shusaku; Tsuboi, Takafumi] Ehime Univ, Matsuyama, Ehime, Japan. [Vinetz, Joseph] Univ Calif San Diego, Div Infect Dis, La Jolla, CA 92093 USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 484 BP 139 EP 139 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200482 ER PT J AU Bhattacharjee, AK Gerena, L Gettyacamin, M Pitzer, K Milhous, WK Kyle, DE AF Bhattacharjee, Apurba K. Gerena, Lucia Gettyacamin, Montip Pitzer, Kevin Milhous, Wilbur K. Kyle, Dennis E. TI In silico pharmacophore for antimalarial activity of the 4(1H)-quinolones to aid discovery of novel causal prophylactic drug candidates SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Bhattacharjee, Apurba K.; Gerena, Lucia; Pitzer, Kevin; Milhous, Wilbur K.; Kyle, Dennis E.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Pitzer, Kevin] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 503 BP 144 EP 144 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200501 ER PT J AU Caridha, D Yourick, D Hudson, T Dow, GS AF Caridha, Diana Yourick, Debra Hudson, Tom Dow, Geoffrey S. TI Mefloquine-induced disruption of calcium homeostasis in mammalian cells may be due to an ionophoric effect similar to that of ionomycin SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Caridha, Diana; Yourick, Debra; Hudson, Tom; Dow, Geoffrey S.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Yourick, Debra/A-2121-2011; Hudson, Thomas/A-9152-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 502 BP 144 EP 144 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200500 ER PT J AU Jenwithisuk, R Ubalee, R Krairojananan, P Suktawonjaroenpon, W Tippayachai, B Yimamnuaychok, N Rachaphaew, N Charurojpakorn, C Trongnipatt, N Kengluecha, A Leelaudomlipi, S Chotivanich, K Udomsangpetch, R Sattabongkot, J AF Jenwithisuk, Rachaneeporn Ubalee, Ratawan Krairojananan, Panadda Suktawonjaroenpon, Wachira Tippayachai, Bousaraporn Yimamnuaychok, Nongnuch Rachaphaew, Nattawan Charurojpakorn, Chulaluck Trongnipatt, Namtip Kengluecha, Ampornpan Leelaudomlipi, Surasak Chotivanich, Kesinee Udomsangpetch, Rachanee Sattabongkot, Jetsumon TI Novel in vitro culture of liver stage human malaria for screening of new anti-malarial compounds SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Jenwithisuk, Rachaneeporn; Ubalee, Ratawan; Krairojananan, Panadda; Suktawonjaroenpon, Wachira; Tippayachai, Bousaraporn; Yimamnuaychok, Nongnuch; Rachaphaew, Nattawan; Charurojpakorn, Chulaluck; Trongnipatt, Namtip; Kengluecha, Ampornpan; Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, United States Army Component Armed Forces, Bangkok 10400, Thailand. [Leelaudomlipi, Surasak] Ramathibodi Hosp, Fac Med, Bangkok, Thailand. [Chotivanich, Kesinee] Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand. [Udomsangpetch, Rachanee] Mahidol Univ, Fac Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 515 BP 148 EP 148 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200512 ER PT J AU Leary, K Brater, DC van de Pol, C Pruett, K Kerr, C Veazey, J Nithyanandan, N Ohrt, C AF Leary, Kevin Brater, D. Craig van de Pol, Corina Pruett, Khadeeja Kerr, Caron Veazey, James Nithyanandan, Nagercoil Ohrt, Colin TI Phase 1 investigation to assess the renal and opthalmic effects of tafenoquine, a novel antimalarial drug SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Leary, Kevin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Brater, D. Craig] Indiana Univ, Sch Med, Indianapolis, IN 46204 USA. [van de Pol, Corina] AcuFocus Inc, Irvine, CA USA. [Pruett, Khadeeja; Kerr, Caron] GlaxoSmithKline Inc, Upper Providence, England. [Veazey, James] US Army Med Materiel Dev Activ, Ft Detrick, MD USA. [Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 520 BP 149 EP 149 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200517 ER PT J AU Folarin, OA Happi, CT Gbotosho, GO Anumudu, C Idowu, DO Sowunmi, A Nwugba, RA Olorunsogo, OO Milhous, W Wirth, DF Oduola, AM AF Folarin, Onikepe A. Happi, Christian T. Gbotosho, Grace O. Anumudu, Chiaka Idowu, Dare O. Sowunmi, Akintunde Nwugba, Rose-Angela Olorunsogo, Olufunsho O. Milhous, Wilbur Wirth, Dyann F. Oduola, Ayoade M. TI Clearance of amodiaquine-resistant Plasmodium falciparum in Nigerian children by immunoglobulin G antibodies to the 19-kDa C-terminal region of merozoite surface protein 1 (MSP-1(19)) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Folarin, Onikepe A.; Happi, Christian T.; Gbotosho, Grace O.; Sowunmi, Akintunde] Univ Ibadan, Coll Med, Inst Adv Med Res & Training, Malaria Res Lab, Ibadan, Nigeria. [Anumudu, Chiaka; Idowu, Dare O.; Nwugba, Rose-Angela] Univ Ibadan, Dept Zool, Ibadan, Nigeria. [Olorunsogo, Olufunsho O.] Univ Ibadan, Dept Biochem, Ibadan, Nigeria. [Milhous, Wilbur] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Wirth, Dyann F.] Harvard Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA. [Oduola, Ayoade M.] Special Programme Res Dev & Res Training Trop Dis, WHO DTR, Geneva, Switzerland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 524 BP 150 EP 151 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200521 ER PT J AU Happi, CT Gbotosho, GO Folarin, OA Sowunmi, A Adedeji, AA Bolaji, OM Balogun, T Milhous, W Wirth, DF Oduola, AM AF Happi, Christian T. Gbotosho, Grace O. Folarin, Onikepe A. Sowunmi, Akintunde Adedeji, Ahmed A. Bolaji, O. M. Balogun, T. Milhous, Wilbur Wirth, Dyann F. Oduola, Ayoade M. TI Selection of Plasmodium falciparum multidrug resistance gene 1 alleles by artemether-lumefantrine in Nigerian children with acute uncomplicated malaria SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Happi, Christian T.] Harvard Sch Publ Hlth, Boston, MA USA. [Gbotosho, Grace O.; Folarin, Onikepe A.; Sowunmi, Akintunde; Adedeji, Ahmed A.; Bolaji, O. M.; Balogun, T.] Univ Ibadan, Coll Med, Inst Adv Med Res & Training, Res Lab, Ibadan, Nigeria. [Milhous, Wilbur] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Oduola, Ayoade M.] WHO TDR, Special Programme Res Dev & Res Training Trop Dis, Geneva, Switzerland. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 527 BP 151 EP 151 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758200524 ER PT J AU Dent, AE Chelimo, K Sumba, P Tisch, D Spring, M Moormann, A Kazura, J AF Dent, Arlene E. Chelimo, Kiprotich Sumba, Peter Tisch, Daniel Spring, Michele Moormann, Ann Kazura, James TI Temporal stability of blood stage malaria immune surrogates of protection in a malaria holoendemic area SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Dent, Arlene E.; Tisch, Daniel; Moormann, Ann; Kazura, James] Case Western Reserve Univ, Cleveland, OH USA. [Chelimo, Kiprotich; Sumba, Peter] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Spring, Michele] Walter Reed Army Inst Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 556 BP 160 EP 160 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201018 ER PT J AU Liepinsh, D AF Liepinsh, Dmitry TI Sterile protection against malaria infection requires tap in spite of completely operative tap-independent vacuolar cross-presentation pathway SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Liepinsh, Dmitry] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 558 BP 161 EP 161 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201020 ER PT J AU Jin, L Takeo, S Iriko, H Kaneko, O Sattabongkot, J Torii, M Aguiar, JC Tsuboi, T AF Jin, Ling Takeo, Satoru Iriko, Hideyuki Kaneko, Osamu Sattabongkot, Jetsumon Torii, Motomi Aguiar, Joao Carlos Tsuboi, Takafumi TI Novel sporozoite antigen discovery of Plasmodium falciparum screened using human immunesera SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Jin, Ling; Takeo, Satoru; Tsuboi, Takafumi] Ehime Univ, Matsuyama, Ehime 790, Japan. [Iriko, Hideyuki] Tottori Univ, Yonago, Tottori, Japan. [Kaneko, Osamu] Nagasaki Univ, Nagasaki, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Torii, Motomi] Ehime Univ, Toon, Ehime, Japan. [Aguiar, Joao Carlos] Naval Med Res Ctr, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 574 BP 165 EP 165 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201036 ER PT J AU Tachibana, M Eitoku, C Otsuki, H Sattabongkot, J Torii, M Tsuboi, T AF Tachibana, Mayumi Eitoku, Chiho Otsuki, Hitoshi Sattabongkot, Jetsumon Torii, Motomi Tsuboi, Takafumi TI Transmission-blocking activity of DNA vaccine encording Plasmodium vivax gametocyte protein, Pvs230 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Tachibana, Mayumi; Eitoku, Chiho; Otsuki, Hitoshi; Torii, Motomi] Ehime Univ, Grad Sch Med, Dept Mol Parasitol, Matsuyama, Ehime 790, Japan. [Sattabongkot, Jetsumon] United States Army Med Component, Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand. [Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 790, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 575 BP 165 EP 165 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201037 ER PT J AU Anyona, SB Hunja, CW Kifude, CM Polhemus, ME Heppner, DG Leach, A Lievens, M Ballou, R Cohen, J Sutherland, C Waitumbi, JN AF Anyona, Samuel B. Hunja, Carol W. Kifude, Carolyne M. Polhemus, Mark E. Heppner, D. Gray Leach, Amanda Lievens, Marc Ballou, Ripley Cohen, Joe Sutherland, Colin Waitumbi, John N. TI Impact of RTS,S/AS02A and RTS,S/AS01B on multiplicity of infections and CSP t-cell epitopes of Plasmodium falciparum in adults participating in a malaria vaccine clinical trial SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Anyona, Samuel B.; Hunja, Carol W.; Kifude, Carolyne M.; Polhemus, Mark E.; Waitumbi, John N.] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. [Heppner, D. Gray] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Leach, Amanda; Lievens, Marc; Ballou, Ripley; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Sutherland, Colin] London Sch Hyg & Trop Med, London, England. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 578 BP 166 EP 166 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201040 ER PT J AU Turell, MJ Lee, JS Richardson, JH Sang, RC Kioko, EN Agawo, MO Pecor, J O'Guinn, ML AF Turell, Michael J. Lee, John S. Richardson, Jason H. Sang, Rosemary C. Kioko, Elizabeth N. Agawo, Maurice O. Pecor, James O'Guinn, Monica L. TI Vector competence of selected Kenyan mosquito (Diptera : Culicidae) species for rift valley fever virus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Turell, Michael J.; Lee, John S.; O'Guinn, Monica L.] United States Army Med Res Inst Infect Dis, Frederick, MD USA. [Richardson, Jason H.; Kioko, Elizabeth N.; Agawo, Maurice O.] US Army Med Res Unit, Nairobi, Kenya. [Sang, Rosemary C.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Pecor, James] Walter Reed Army Inst Res, Washington, DC USA. RI Richardson, Jason/A-9441-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 598 BP 171 EP 171 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201060 ER PT J AU Guerena-Burgueno, F Smoak, BL Nitayapan, S McLain, JD Ayuttaya, TTN Siriyanonda, D Jarman, RG Carr, KW Wendel, CE AF Guerena-Burgueno, Fernando Smoak, Bonnie L. Nitayapan, Sorachai McLain, James D. Ayuttaya, Tippawan T. Na Siriyanonda, Duangsuda Jarman, Richard G. Carr, Kathleen W. Wendel, Clifford E. TI Biosurety and regional preparedness for a potential influenza pandemic and other threats posed by biological select agents and toxins: The Armed Forces Research Institute of the Medical Sciences experience SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Guerena-Burgueno, Fernando; Smoak, Bonnie L.; Nitayapan, Sorachai; McLain, James D.; Ayuttaya, Tippawan T. Na; Siriyanonda, Duangsuda; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Carr, Kathleen W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wendel, Clifford E.] USA Med Res & Mat Command, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 618 BP 176 EP 177 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201080 ER PT J AU Read, AL Durvasula, R Hurwitz, I Subhadra, B Scott, M Ghosh, K McKelvey, R Hillesland, H Das, P AF Read, Amber L. Durvasula, Ravi Hurwitz, Ivy Subhadra, Bobban Scott, Mathews Ghosh, Kashinath McKelvey, Robin Hillesland, Heidi Das, Pradeep TI A paratransgenic approach to control of visceral leishmaniasis: Aerobic gut bacterial identification from Phleotomus argentipus SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Read, Amber L.; Durvasula, Ravi; Hurwitz, Ivy; Subhadra, Bobban; Scott, Mathews; McKelvey, Robin; Hillesland, Heidi] Univ New Mexico, Albuquerque, NM USA. [Ghosh, Kashinath] Walter Reed Army Inst Res, Washington, DC USA. [Das, Pradeep] Rajendra Mem Res Inst Med Sci, Patna, Bihar, India. NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 624 BP 178 EP 178 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201085 ER PT J AU Thriemer, K Haque, R Starzengruber, P Marma, ASP Khan, WA Vossen, M Akter, S Fukuda, M Noedl, H AF Thriemer, Kamala Haque, Rashidul Starzengruber, Peter Marma, Aung Swe Prue Khan, Wasif Ali Vossen, Matthias Akter, Selim Fukuda, Mark Noedl, Harald TI Azithromycin combination therapy for the treatment of uncomplicated falciparum malaria: Preliminary results from an open label randomized controlled trial in Bangladesh SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Thriemer, Kamala; Starzengruber, Peter; Vossen, Matthias; Noedl, Harald] Med Univ Vienna, Vienna, Austria. [Haque, Rashidul; Khan, Wasif Ali; Akter, Selim] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh. [Marma, Aung Swe Prue] Bandarban Sadar Hosp, Bandarban, Bangladesh. [Fukuda, Mark] USA Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 636 BP 182 EP 182 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201097 ER PT J AU Ohrt, C Jones, L Notsch, J Johnson, J McCalmont, W Lanteri, C Lin, AJ Milhous, W Magill, A Ellis, W AF Ohrt, Colin Jones, Lahna Notsch, John Johnson, Jacob McCalmont, William Lanteri, Charlotte Lin, A. J. Milhous, Wilbur Magill, Alan Ellis, William TI Review of experimental therapeutics chemical information system for all compounds active in prophylaxis animal models SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Ohrt, Colin; Notsch, John; Johnson, Jacob; McCalmont, William; Lanteri, Charlotte; Lin, A. J.; Milhous, Wilbur; Magill, Alan; Ellis, William] Walter Reed Army Inst Res, Silver Spring, MD USA. [Jones, Lahna] Thermo Fisher Sci Inc, Gaithersburg, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 650 BP 186 EP 186 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201111 ER PT J AU Waters, NC Gaona, HW Johnson, JD Hudson, TH Bhonsle, JB Huddler, DP Heady, TN Kreishman-Deitrick, M McCalmont, WF Bhattacharjee, AK Prigge, ST Roncal, NE Lopez-Sanchez, M Gerena, L Lee, PJ AF Waters, Norman C. Gaona, Heather W. Johnson, Jacob D. Hudson, Thomas H. Bhonsle, Jayendra B. Huddler, Donald P. Heady, Tiffany N. Kreishman-Deitrick, Mara McCalmont, William F. Bhattacharjee, Apurba K. Prigge, Sean T. Roncal, Norma E. Lopez-Sanchez, Miriam Gerena, Lucia Lee, Patricia J. TI Selective inhibitors of B-ketoacyl ACP synthase III (PFKASIII) in Plasmodium falciparum fatty acid synthesis: From target validation to in vivo efficacy SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Waters, Norman C.; Gaona, Heather W.; Johnson, Jacob D.; Hudson, Thomas H.; Bhonsle, Jayendra B.; Huddler, Donald P.; Heady, Tiffany N.; Kreishman-Deitrick, Mara; McCalmont, William F.; Bhattacharjee, Apurba K.; Roncal, Norma E.; Lopez-Sanchez, Miriam; Gerena, Lucia; Lee, Patricia J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Prigge, Sean T.] Johns Hopkins Univ, Baltimore, MD USA. RI Bhonsle, Jayendra/A-9139-2011; Hudson, Thomas/A-9152-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 656 BP 188 EP 188 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201117 ER PT J AU Griffith, M McCall, S Hospenthal, D Murray, C AF Griffith, Matthew McCall, Suzanne Hospenthal, Duane Murray, Clinton TI Efficacy of single dose levofloxacin for treatment of acute leptospirosis in a hamster model SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Griffith, Matthew; McCall, Suzanne; Hospenthal, Duane; Murray, Clinton] Brooke Army Med Ctr, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 714 BP 205 EP 205 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201175 ER PT J AU Griffith, M Beckius, M Pimentel, G Ressner, R Hospenthal, D Murray, C AF Griffith, Matthew Beckius, Miriam Pimentel, Guillermo Ressner, Roseanne Hospenthal, Duane Murray, Clinton TI Antimicrobial susceptibility of clinical leptospira isolates SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Griffith, Matthew; Beckius, Miriam; Ressner, Roseanne; Hospenthal, Duane; Murray, Clinton] Brooke Army Med Ctr, Ft Sam Houston, TX USA. [Pimentel, Guillermo] US Naval Med Res Unit 3, Cairo, Egypt. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 715 BP 205 EP 205 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201176 ER PT J AU Remich, SA Otieno, W Omariba, D Polhemus, M Ogutu, B Walsh, D Miller, R AF Remich, Shon A. Otieno, Walter Omariba, Duke Polhemus, Mark Ogutu, Berhnards Walsh, Doug Miller, Robert TI Prospective assessment of severe malaria for clinical trials at institutions in western Kenya SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Remich, Shon A.] Walter Reed Army Med Ctr, Washington, DC USA. [Otieno, Walter; Omariba, Duke] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Polhemus, Mark] USA, Med Unit, Kisumu, Kenya. [Ogutu, Berhnards] Kemri Med Res Inst, Kisumu, Kenya. [Walsh, Doug] USA, Med Res Unit Kenya, Kisumu, Kenya. [Miller, Robert] Walter Reed Army Inst Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 735 BP 211 EP 211 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201196 ER PT J AU Ibadova, GA Khodiev, AV Nechmireva, TS Abdukhalilova, GK Madyarov, RS Mason, CJ Bodhidatta, L AF Ibadova, Gulnara A. Khodiev, Aybek V. Nechmireva, Tamara S. Abdukhalilova, Gulnara K. Madyarov, Ruslan S. Mason, Carl J. Bodhidatta, Ladaporn TI Prevalence of diarrheagenic E-coli among bacterial isolates in patients with acute diarrhea in Uzbekistan: Three years surveillance project results SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Ibadova, Gulnara A.; Khodiev, Aybek V.; Nechmireva, Tamara S.; Abdukhalilova, Gulnara K.; Madyarov, Ruslan S.] Sci Res Inst Epidemiol Microbiol & Infect Dis, Tashkent, Uzbekistan. [Mason, Carl J.; Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 744 BP 214 EP 214 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201205 ER PT J AU Pastor, G Burga, R Jones, F Perez, J Meza, R Bernal, M Mezal, Y Espinosa, B Kaminski, R Oaks, E Hall, ER AF Pastor, Giovanna Burga, Rosa Jones, Franca Perez, Juan Meza, Rina Bernal, Maruja Mezal, Yocelinda Espinosa, Benjamin Kaminski, Robert Oaks, Edwin Hall, Eric R. TI Surveillance for acute diarrheal diseases among Peruvian military recruits at the Vargas-Guerra Army (VGE) Base in Iquitos, Peru: February 2004 February 2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Pastor, Giovanna; Burga, Rosa; Perez, Juan; Meza, Rina; Bernal, Maruja; Mezal, Yocelinda; Espinosa, Benjamin; Hall, Eric R.] Naval Med Res Ctr Detachment, US Embassy, Lima, Peru. [Jones, Franca] Naval Med Res Ctr, Silver Spring, MD USA. [Kaminski, Robert; Oaks, Edwin] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 750 BP 215 EP 216 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201211 ER PT J AU Velasco, JMS Alera, MT Ypil-Butac, CA Mammen, MP Gibbons, RV Jarman, R Nisalak, A Yoon, IK AF Velasco, John Mark S. Alera, Maria Theresa Ypil-Butac, Charity A. Mammen, Mammen P. Gibbons, Robert V. Jarman, Richard Nisalak, Ananda Yoon, In-Kyu TI Serotype-specific clinical characteristics of hospitalized dengue in the Philippines SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Velasco, John Mark S.; Ypil-Butac, Charity A.] Armed Forces Res Inst Med Sci, Manila, Philippines. [Alera, Maria Theresa] San Lazaro Hosp, Manila, Philippines. [Mammen, Mammen P.; Gibbons, Robert V.; Jarman, Richard; Nisalak, Ananda; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 760 BP 218 EP 219 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201221 ER PT J AU Gibbons, R Kalanarooj, S Jarman, R Nisalak, A Vaughn, D Endy, T Mammen, M Srikiatkhachorn, A AF Gibbons, Robert Kalanarooj, Siripen Jarman, Richard Nisalak, Ananda Vaughn, David Endy, Timothy Mammen, Mammen Srikiatkhachorn, Anon TI An analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions, dengue hemorrhagic fever, and serotype sequences SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Gibbons, Robert; Jarman, Richard; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Kalanarooj, Siripen] Queen Sirikit Inst Child Hlth, Bangkok, Thailand. [Vaughn, David] GlaxoSmithKline Inc, King Of Prussia, PA USA. [Endy, Timothy] SUNY Syracuse, Syracuse, NY USA. [Mammen, Mammen] USA Med Res & Mat Command, Ft Detrick, MD USA. [Srikiatkhachorn, Anon] Univ Massachusetts, Sch Med, Worcester, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 763 BP 219 EP 219 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201224 ER PT J AU Jarman, RG Klungthong, C Thaisomboonsuk, B Nisalak, A Rothman, A Green, S Thomas, S Toussaint, JF Kalanarooj, S Gibbons, R AF Jarman, Rick G. Klungthong, Chonticha Thaisomboonsuk, Butsaya Nisalak, Ananda Rothman, Alan Green, Sharone Thomas, Stephen Toussaint, Jean Francois Kalanarooj, Siripen Gibbons, Robert TI Analysis of ns-1 antigen and viremia in hospitalized dengue hemorrhagic fever and dengue fever patients in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Jarman, Rick G.; Klungthong, Chonticha; Thaisomboonsuk, Butsaya; Nisalak, Ananda; Gibbons, Robert] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Univ Massachusetts, Sch Med, Worcester, MA USA. [Rothman, Alan; Green, Sharone; Thomas, Stephen] Walter Reed Army Inst Res, Silver Spring, MD USA. [Toussaint, Jean Francois] GlaxoSmithKline Inc, Rixensart, Belgium. [Kalanarooj, Siripen] Queen Sirikit Inst Child Hlth, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 765 BP 220 EP 220 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201226 ER PT J AU Nisalak, A Halstead, SB Endy, T Thaisomboonsuk, B Rothman, A Green, S Gibbons, R Jarman, RG AF Nisalak, Ananda Halstead, Scott B. Endy, Timothy Thaisomboonsuk, Butsaya Rothman, Alan Green, Sharone Gibbons, Robert Jarman, Richard G. TI Sequence of infection rates determined using single dilution neutralization assay from 1998-2001 Kamphaeng Phet Thailand prospective study SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Nisalak, Ananda; Thaisomboonsuk, Butsaya; Gibbons, Robert; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Halstead, Scott B.] Support R&D Pediat Dengue Vaccine Initiat, Bethesda, MD USA. [Endy, Timothy] SUNY Syracuse, Syracuse, NY USA. [Rothman, Alan; Green, Sharone] Univ Massachusetts, Sch Med, Worcester, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 767 BP 221 EP 221 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201228 ER PT J AU Pilakasiri, K Pilakasiri, C Roongruangchai, J Roonrruangchai, K Sobhon, P AF Pilakasiri, Kajee Pilakasiri, Chaiyaphruk Roongruangchai, Jantinna Roonrruangchai, Kosol Sobhon, Prasert TI Ultrastructural study of Brugia pahangi: A rich antigenic source SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Pilakasiri, Kajee; Roongruangchai, Jantinna] Siriraj Hosp, Fac Med, Dept Anat, Bangkok, Thailand. [Pilakasiri, Chaiyaphruk] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Roonrruangchai, Kosol] Siriraj Hosp, Fac Med, Dept Parasitol, Bangkok, Thailand. [Sobhon, Prasert] Mahidol Univ, Fac Sci, Dept Anat, Bangkok 10400, Thailand. RI Sobhon, Prasert /B-9198-2009 NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 783 BP 225 EP 225 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201243 ER PT J AU Gaona, HW Lee, PJ Bhonsle, JB Prigge, ST Hudson, TH Reynolds, KA McCalmont, WF Heady, TN Huddler, DP Kreishman-Deitrick, M Bhattacharjee, AK Gerena, L Roncal, NE Lopez-Sanchez, M Johnson, JD Waters, NC AF Gaona, Heather W. Lee, Patricia J. Bhonsle, Jayendra B. Prigge, Sean T. Hudson, Thomas H. Reynolds, Kevin A. McCalmont, William F. Heady, Tiffany N. Huddler, Donald P. Kreishman-Deitrick, Mara Bhattacharjee, Apurba K. Gerena, Lucia Roncal, Norma E. Lopez-Sanchez, Miriam Johnson, Jacob D. Waters, Norman C. TI Using 3D-QSAR to identify new chemical classes that specifically inhibit B-ketoacyl ACP synthase III (PFKASIII) in Plasmodium falciparum SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Gaona, Heather W.; Lee, Patricia J.; Bhonsle, Jayendra B.; Hudson, Thomas H.; McCalmont, William F.; Heady, Tiffany N.; Huddler, Donald P.; Kreishman-Deitrick, Mara; Bhattacharjee, Apurba K.; Gerena, Lucia; Roncal, Norma E.; Lopez-Sanchez, Miriam; Johnson, Jacob D.; Waters, Norman C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Prigge, Sean T.] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD USA. [Reynolds, Kevin A.] Portland State Univ, Portland, OR 97207 USA. RI Bhonsle, Jayendra/A-9139-2011; Hudson, Thomas/A-9152-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 817 BP 234 EP 235 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201276 ER PT J AU Gutteridge, CE Bhattacharjee, AK Hoffman, MM AF Gutteridge, Clare E. Bhattacharjee, Apurba K. Hoffman, Marshall M. TI The relationship between substituted 1,7-diaminoisoquinoline structure and antimalarial activity SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Gutteridge, Clare E.; Hoffman, Marshall M.] USN Acad, Annapolis, MD USA. [Bhattacharjee, Apurba K.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 819 BP 235 EP 235 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201278 ER PT J AU Reinbold, DD Dennuil, RA Waters, NC Johnson, JD AF Reinbold, Drew D. Dennuil, Richard A. Waters, Norman C. Johnson, Jacob D. TI Assessment of malaria in vitro drug combination screening and mixed strain infections using the SYBR green fluorescence assay SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Reinbold, Drew D.; Dennuil, Richard A.; Waters, Norman C.; Johnson, Jacob D.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Valle, Ruben/A-7512-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 820 BP 235 EP 235 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201279 ER PT J AU Gosi, P Fukuda, M Schaecher, K Lanar, D Khusmith, S Khalambaheti, T Miller, S AF Gosi, Panita Fukuda, Mark Schaecher, Kurt Lanar, David Khusmith, Srisin Khalambaheti, Thareerat Miller, Scott TI Polymorphisms of Plasmodium vivax duffy binding protein in isolates from Thai patients SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Gosi, Panita; Fukuda, Mark; Schaecher, Kurt] USA, Med Component Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Lanar, David; Miller, Scott] Walter Reed Army Inst Res, Silver Spring, MD USA. [Khusmith, Srisin; Khalambaheti, Thareerat] Mahidol Univ, Bangkok 10700, Thailand. RI Lanar, David/B-3560-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 863 BP 247 EP 247 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201322 ER PT J AU Conn, JE Li, C Povoa, MM Sallum, MA Lima, JB Wilkerson, RC AF Conn, Jan E. Li, Cong Povoa, Marinete M. Sallum, Maria Anice Lima, Jose Bento Wilkerson, Richard C. TI Genetic population structure in the malaria vector Anopheles marajoara in Northeastern South America SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Conn, Jan E.] Wadsworth Ctr, New York State Dept Hlth, Slingerlands, NY USA. [Li, Cong; Wilkerson, Richard C.] Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Suitland, NY USA. [Povoa, Marinete M.] Inst Evandro Chagas, Programa Pesquisas Malaria, Belem, Para, Brazil. [Sallum, Maria Anice] Univ Sao Paulo, Dept Epidemiol, BR-05508 Sao Paulo, Brazil. [Lima, Jose Bento] Fundacao Oswaldo Cruz, Dept Entomol, Rio De Janeiro, Brazil. RI Sallum, Maria/B-8537-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 882 BP 252 EP 252 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201341 ER PT J AU Foley, DH Rueda, LM Wilkerson, RC AF Foley, Desmond H. Rueda, Leopoldo M. Wilkerson, Richard C. TI Identifying the geographical convergence of Anopheles and Plasmodium SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Foley, Desmond H.; Rueda, Leopoldo M.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Suitland, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 881 BP 252 EP 252 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201340 ER PT J AU Vaughan, JA Bell, JA Brewer, CM Tkach, VV Hassan, HK Unnasch, TR Turell, MJ AF Vaughan, Jefferson A. Bell, Jeffrey A. Brewer, Christina M. Tkach, Vasyl V. Hassan, Hassan K. Unnasch, Thomas R. Turell, Michael J. TI Passerine filariasis and the rapid spread of west nile virus - A real-life example of microfilarial enhancement of arboviral transmission by mosquitoes? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Vaughan, Jefferson A.; Bell, Jeffrey A.; Brewer, Christina M.; Tkach, Vasyl V.] Univ N Dakota, Grand Forks, ND USA. [Hassan, Hassan K.] Univ Alabama, Birmingham, AL USA. [Unnasch, Thomas R.; Turell, Michael J.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 880 BP 252 EP 252 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201339 ER PT J AU Noedl, H Thap, LC Se, Y Socheat, D Peou, S Schaecher, K Sriwichai, S Teja-Isavadharm, P Smith, B Jongsakul, K Surasri, S Fukuda, MM AF Noedl, Harald Thap, Lon Chan Se, Youry Socheat, Duong Peou, Sok Schaecher, Kurt Sriwichai, Sabaithip Teja-Isavadharm, Paktiya Smith, Bryan Jongsakul, Krisada Surasri, Sittidech Fukuda, Mark M. TI Artemisinin resistance in Cambodia? SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Noedl, Harald; Se, Youry; Schaecher, Kurt; Sriwichai, Sabaithip; Teja-Isavadharm, Paktiya; Smith, Bryan; Jongsakul, Krisada; Surasri, Sittidech; Fukuda, Mark M.] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. [Thap, Lon Chan; Socheat, Duong; Peou, Sok] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 934 BP 267 EP 267 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201393 ER PT J AU Anyamba, A Chretien, JP Small, J Tucker, CJ Formenty, P Richardson, J Britch, S Linthicum, KJ AF Anyamba, Assaf Chretien, Jean-Paul Small, Jennifer Tucker, Compton J. Formenty, Pierre Richardson, Jason Britch, Seth Linthicum, Kenneth J. TI Forecasting the temporal and spatial distribution of a rift valley fever outbreak in east Africa: 2006-2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Anyamba, Assaf; Small, Jennifer; Tucker, Compton J.] Goddard Space Flight Ctr, Biospher Sci Branch, Greenbelt, MD USA. [Chretien, Jean-Paul] Walter Reed Army Inst Res, Dept Def Global Emerging Infect, Surveillance & Response Syst, Silver Spring, MD USA. [Formenty, Pierre] WHO, Dept Epidem & Pandem Alert & Response, Geneva, Switzerland. [Richardson, Jason] US Army Med Res Unit, Dept Entomol, Nairobi, Kenya. [Britch, Seth; Linthicum, Kenneth J.] USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL USA. RI Richardson, Jason/A-9441-2011 NR 0 TC 1 Z9 1 U1 1 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 989 BP 282 EP 283 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201447 ER PT J AU Rubins, K Goff, J Mucker, E Hartmann, C Miller, D Raymond, J Huggins, J Hensley, L AF Rubins, Kate Goff, Jay Mucker, Eric Hartmann, Chris Miller, David Raymond, JoLynne Huggins, John Hensley, Lisa TI Pathogenesis of monkeypox in cynomolgus macaques: Development of a non-human primate model. for therapeutic and vaccine testing SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Rubins, Kate] Whitehead Inst, Cambridge, MA USA. [Goff, Jay; Mucker, Eric; Hartmann, Chris; Miller, David; Raymond, JoLynne; Huggins, John; Hensley, Lisa] US Army Med Res Inst Infect Dis, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 992 BP 283 EP 284 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201450 ER PT J AU Saunders, D Garges, E Kosmowski, A Bennett, K Cersovsky, S Mott, R Magill, A AF Saunders, David Garges, Eric Kosmowski, Andrew Bennett, Kent Cersovsky, Steven Mott, Robert Magill, Alan TI Doxycycline hyclate tolerability and compliance as daily oral malaria prophylaxis in field conditions: Experience of the 10th mountain division (LI), OEF VII SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Saunders, David; Garges, Eric; Kosmowski, Andrew; Bennett, Kent; Cersovsky, Steven; Mott, Robert; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 1008 BP 288 EP 288 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201466 ER PT J AU Weina, PJ Miller, RS Kuppers, R Fornasini, G Milhous, WK AF Weina, Peter J. Miller, R. Scott Kuppers, Rudolf Fornasini, Gianfranco Milhous, Wilbur K. TI Licensed CGMP intravenous artesunate availability in the developed world: Light finally at the end of the tunnel SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Weina, Peter J.; Miller, R. Scott; Milhous, Wilbur K.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Kuppers, Rudolf] Mil Infect Dis Res Program, Ft Detrick, MD USA. [Fornasini, Gianfranco] Sigma Tau Pharmaceut Inc, Gaithersburg, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 1009 BP 289 EP 289 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201467 ER PT J AU Haynes, JD Moch, JK Komisar, JL Snavely, JD AF Haynes, J. David Moch, J. Kathleen Komisar, Jack L. Snavely, Jeffrey D. TI Selection of mutated Plasmodium falciparum malaria parasites for long-lived invasive merozoites by limiting their contact with erythrocytes (RBC) using low RBC concentrations in continuous motion suspension cultures SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Haynes, J. David; Moch, J. Kathleen; Komisar, Jack L.; Snavely, Jeffrey D.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 1015 BP 290 EP 291 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201473 ER PT J AU Jiang, J Graf, PC Stromdahl, EY Richards, AL AF Jiang, Ju Graf, Paul C. Stromdahl, Ellen Y. Richards, Allen L. TI Risk of spotted fever group rickettsia infection to US military personnel SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 56th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 04-08, 2007 CL Philadelphia, PA SP Amer Soc Trop Med & Hyg C1 [Jiang, Ju; Graf, Paul C.; Richards, Allen L.] Naval Med Res Ctr, Silver Spring, MD USA. [Stromdahl, Ellen Y.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 SU S MA 1065 BP 305 EP 306 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228UN UT WOS:000250758201523 ER PT J AU Gibbons, RV Kalanarooj, S Jarman, RG Nisalak, A Vaughn, DW Endy, TP Mammen, MP Srikiatkhachorn, A AF Gibbons, Robert V. Kalanarooj, Siripen Jarman, Richard G. Nisalak, Ananda Vaughn, David W. Endy, Timothy P. Mammen, Mammen P., Jr. Srikiatkhachorn, Anon TI Analysis of repeat hospital admissions for dengue to estimate the frequency of third or fourth dengue infections resulting in admissions and dengue hemorrhagic fever, and serotype sequences SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID JAPANESE ENCEPHALITIS; VIRUS-INFECTIONS; SHOCK SYNDROME; MOSQUITOS; EPIDEMIC; PATHOGENESIS; PROTECTION; RESPONSES; OUTBREAK; INFANTS AB Immunity to a single dengue virus (DENV) infection does not provide heterologous immunity to subsequent infection. In fact, the greatest risk for dengue hemorrhagic fever (DHF) is with a second DENV serotype exposure. The risk for DHF with a third or fourth dengue infection relative to a first or second exposure is not known. An analysis of our database of children admitted to the Queen Sirikit National Institute of Child Health and Kamphaeng Phet Provincial Hospital with suspected dengue illness revealed that the number of dengue admissions caused by a third or fourth DENV infection was extremely low (0.08-0.8%). Once admitted, the risk for DHF relative to dengue fever was not different for those experiencing third or fourth DENV infections over those experiencing a second DENV infection. We document new dengue serotype infection sequences leading to DHF of 1-4, 2-3, 3-1, and 3-4. C1 Queen Sirikit Inst Child Hlth, Bangkok, Thailand. USA Med Component Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD USA. USA, Med Res & Materiel Command, Mil Infect Dis Res Program, Ft Detrick, MD USA. RP Gibbons, RV (reprint author), APO AP, Bangkok 96546, Thailand. EM Robert.gibbons@afrims.org FU NIAID NIH HHS [P01-AI34533] NR 28 TC 93 Z9 94 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 BP 910 EP 913 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228MW UT WOS:000250735000026 PM 17984352 ER PT J AU Coldren, RL Jongsakul, K Vayakornvichit, S Noedl, H Fukuda, MM AF Coldren, Rodney L. Jongsakul, Krisada Vayakornvichit, Sankiat Noedl, Harald Fukuda, Mark M. TI Apparent relapse of imported Plasmodium ovale malaria in a pregnant woman SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INFECTIONS; FALCIPARUM; PARASITE; SAFETY AB A 27 week pregnant woman who had lived in Bangkok, Thailand, for 18 months presented to her obstetrician with a 1-week history of intermittent fever and malaise. Medical history was significant for multiple episodes of malaria during her 10 years of employment in sub-Saharan Africa before her relocation to Thailand. The initial malaria smear was negative. She returned a week later with no resolution of her symptoms, at which time she was found to have Plasmodium ovate by microscopy and polymerase chain reaction. She had an excellent response to chloroquine, which she continued weekly until 36 weeks of gestation. She delivered a healthy term infant and received radical cure with primaquine after cessation of breastfeeding. This case shows challenging issues in detection and management of imported P. ovate malaria. C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Samitivej Hosp, Bangkok, Thailand. RP Coldren, RL (reprint author), APO, USAMC AFRIMS, Bangkok 96546, Thailand. EM Rodney.coldren@afrims.org NR 20 TC 13 Z9 13 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD NOV PY 2007 VL 77 IS 5 BP 992 EP 994 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 228MW UT WOS:000250735000039 PM 17984365 ER PT J AU Watson, NE Siegler, WC Hoggard, JC Synovec, RE AF Watson, Nathanial E. Siegler, W. Christopher Hoggard, Jamin C. Synovec, Robert E. TI Comprehensive three-dimensional gas chromatography with parallel factor analysis SO ANALYTICAL CHEMISTRY LA English DT Article ID FLIGHT MASS-SPECTROMETRY; PRINCIPAL COMPONENT ANALYSIS; X GC-TOFMS; PERFORMANCE LIQUID-CHROMATOGRAPHY; CAPILLARY-ZONE-ELECTROPHORESIS; CHEMOMETRIC ANALYSIS; STATISTICAL-THEORY; 2-DIMENSIONAL SEPARATIONS; AUTOMATED INSTRUMENTATION; PIECEWISE ALIGNMENT AB Development of a comprehensive, three-dimensional gas chromatograph (GC(3)) instrument is described. The instrument utilizes two six-port diaphragm valves as the interfaces between three, in-series capillary columns housed in a standard Agilent 6890 gas chromatograph fitted with a high data acquisition rate flame ionization detector. The modulation periods for sampling column one by column two and column two by column three are set so that a minimum of three slices (more commonly four or five) are acquired by the subsequent dimension resulting in both comprehensive and quantitative data. A 26-component test mixture and quantitative standards are analyzed using the GC(3) instrument. A useful methodology for three-dimensional (3D) data analysis is evaluated, based on the chemometric technique parallel factor analysis (PARAFAC). Since the GC(3) instrument produces trilinear data, we are able to use this powerful chemometric technique, which is better known for the analysis of two-dimensional (2D) separations with multichannel detection (e.g., GC x GC-TOFMS) or multiple samples (or replicates) of 2D data. Using PARAFAC, we mathematically separate (deconvolute) the 3D data "volume" for overlapped analytes (i.e., ellipsoids), provided there is sufficient chromatographic resolution in each of the three separation dimensions. Additionally, PARAFAC is applied to quantify analyte standards. For the quantitative analysis, it is demonstrated that PARAFAC may provide a 10-fold improvement in the signal-to-noise ratio relative to a traditional integration method applied to the raw, baseline-corrected data. The GC(3) instrument obtains a 3D peak capacity of 3500 at a chromatographic resolution of one in each separation dimension. Furthermore, PARAFAC deconvoludon provides a considerable enhancement in the effective 3D peak capacity. C1 Univ Washington, Dept Chem, Seattle, WA 98195 USA. US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Synovec, RE (reprint author), Univ Washington, Dept Chem, Box 351700, Seattle, WA 98195 USA. EM synovec@chem.washington.edu NR 41 TC 38 Z9 38 U1 2 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD NOV 1 PY 2007 VL 79 IS 21 BP 8270 EP 8280 DI 10.1021/ac070829x PG 11 WC Chemistry, Analytical SC Chemistry GA 226JH UT WOS:000250584800048 PM 17896828 ER PT J AU Martini, WZ Holcomb, JB AF Martini, Wenjun Z. Holcomb, John B. TI Acidosis and coagulopathy - The differential effects on fibrinogen synthesis and breakdown in pigs SO ANNALS OF SURGERY LA English DT Article ID LIFE-THREATENING COAGULOPATHY; TRAUMA PATIENT HYPOTHERMIA; INDEPENDENT CONTRIBUTIONS; COAGULATION; METABOLISM; BLOOD; SWINE; STREPTOKINASE; TRANSFUSION AB Objective: Uncontrolled bleeding from coagulopathy signals imminent death in severely injured patients. Acidosis is an important predictor of coagulopathy, but the underlying contributing mechanisms are unclear. This study was designed to investigate the effects of acidosis on fibrinogen metabolism and coagulation function in a swine model. Methods: Twelve pigs were randomly divided into the control (n = 6) and acid (n = 6) groups. Acidosis of pH 7.1 was induced by infusion of 0.2 M HCl in lactated Ringer solution in the acid group. Afterward, an infusion of stable isotope 1-C-13-phenylalanine (6 hours) and d(5)-phenylalanine (4 hours) was performed. Blood samples were withdrawn hourly to quantify fibrinogen synthesis and degradation rates using gas chromatograph and mass spectrometry analysis. To correlate changes in fibrinogen metabolism, coagulation changes were assessed by prolonged prothrombin time, partial activated thromboplastin time, activated clotting time, and thrombelastograph (TEG). Results: Acidosis caused decreases in mean arterial pressure, arterial bicarbonate concentration, base excess, fibrinogen concentration, and platelet counts. Acidosis increased fibrinogen degradation rate from the control value of 4.3 +/- 1.0 mg/kg/h to 11.8 +/- 1.4 mg/kg/h (P < 0.05), with no effect on fibrinogen synthesis. Prolonged prothrombin time, partial activated thromboplastin time, activated clotting time were consistently prolonged by acidosis (all P < 0.05). Clotting rapidity (angle alpha in TEG) was decreased from a baseline value of 73.3 +/- 1.1 degree to 63.0 +/- 2.4 degree (P < 0.05). Clot strength (maximum amplitude in TEG) was decreased from a baseline value of 72.2 +/- 1.4 mm to 56.2 +/- 3.1 mm (P < 0.05). Conclusions: Acidosis compromised the clotting process and accelerated fibrinogen consumption with no effect on fibrinogen production, resulting in a deficit in fibrinogen availability. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM wenjun.martini@amedd.army.mil NR 28 TC 68 Z9 69 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD NOV PY 2007 VL 246 IS 5 BP 831 EP 835 DI 10.1097/SLA.0b013e3180cc2e94 PG 5 WC Surgery SC Surgery GA 229AJ UT WOS:000250773400021 PM 17968176 ER PT J AU Ellsworth, RE Ellsworth, DL Love, B Patney, HL Hoffman, LR Kane, J Hooke, JA Shriver, CD AF Ellsworth, Rachel E. Ellsworth, Darrell L. Love, Brad Patney, Heather L. Hoffman, Laurel R. Kane, Jennifer Hooke, Jeffrey A. Shriver, Craig D. TI Correlation of levels and patterns of genomic instability with histological grading of DCIS SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE allelic imbalance; ductal carcinoma-in-situ; genomic instability; histological grade; tumor classification ID CARCINOMA IN-SITU; BREAST-CANCER; HETEROZYGOSITY; AMPLIFICATION; P53; EXPRESSION; DISEASE AB Background: Histological grading of ductal carcinoma-in-situ (DCIS) lesions separates DCIS into three subgroups (well-, moderately, or poorly differentiated). It is unclear, however, whether breast disease progresses along a histological continuum or whether each grade represents a separate disease. In this study, levels and patterns of allelic imbalance (AI) were examined in DCIS lesions to develop molecular models that can distinguish pathological classifications of DCIS. Methods: Laser microdissected DNA samples were collected from DCIS lesions characterized by a single pathologist including well- (n = 18), moderately (n = 35), and poorly differentiated (n = 47) lesions. A panel of 52 microsatellite markers representing 26 chromosomal regions commonly altered in breast cancer was used to assess patterns of AI. Results: The overall frequency of AI increased significantly (P < .001) with increasing grade (well differentiated, 12%; moderately differentiated, 17%; poorly differentiated, 26%). Levels of AI were not significantly different between well- and moderately differentiated grades of disease but were significantly higher (P < .0001) in poorly differentiated compared with well- or moderately differentiated disease. No statistically significant differences in patterns of AI were detected between well- and moderately differentiated disease; however, AI occurred significantly more frequently (P < .05) in high-grade lesions at chromosomes 6q25-q27, 8q24, 9p21, 13q14, and 17p13.1, and significantly more frequently in low-grade lesions at chromosome 16q22.3-q24.3. Conclusions: The inability to discriminate DCIS at the genetic level suggests that grades 1 and 2 DCIS may represent a single, non-high-grade form of DCIS, whereas poorly differentiated DCIS seems to be a genetically more advanced disease that may represent a discrete disease entity, characterized by a unique spectrum of genetic alterations. C1 Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. Invitrogen Informat, Carlsbad, CA 92008 USA. Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. Henry M Jackson Fdn Advancement Mil Med, Rockville, MD 20852 USA. RP Ellsworth, RE (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org NR 28 TC 17 Z9 18 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD NOV PY 2007 VL 14 IS 11 BP 3070 EP 3077 DI 10.1245/s10434-007-9459-8 PG 8 WC Oncology; Surgery SC Oncology; Surgery GA 221CH UT WOS:000250204500008 PM 17549568 ER PT J AU Callaghan, KA Becker, TE Ellsworth, DL Hooke, JA Ellsworth, RE Shriver, CD AF Callaghan, Karen A. Becker, Tyson E. Ellsworth, Darrell L. Hooke, Jeffrey A. Ellsworth, Rachel E. Shriver, Craig D. TI Genomic instability and the development of metastatic lymph node tumors SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE allelic imbalance; breast cancer; tumor progression; axillary lymph node; metastasis ID PRIMARY BREAST CARCINOMAS; GENE PROTEIN PRODUCT; CHROMOSOME ARM 16Q; ALLELIC LOSS; CANCER PROGRESSION; CELL-LINES; HETEROZYGOSITY; ACCUMULATION; REGIONS; BRCA2 AB Background: Although recent data suggest that cells with metastatic potential disseminate from the primary breast tumor early in tumor development, the mechanism by which disseminated breast cancer cells proliferate within foreign tissues is not well understood. Here, we examined levels and patterns of allelic imbalance (AI) in metastatic lymph node (LN) tumors to identify molecular signals that promote the survival and growth of disseminated breast tumor cells. Methods: DNA from 106 metastatic LN tumors from 25 patients was isolated after laser microdissection of pure tumor cell populations. AI was assessed at 26 chromosomal regions frequently altered in breast cancer. Tumor burden was calculated by dividing the area of the metastatic tumor in the node by the area of the entire LN. Results: Metastatic tumor burden ranged from focal to complete replacement of the LN with tumor. Grouping the nodes as < 25% tumor, 25-50% tumor, 50-75% tumor, and >= 75% tumor replacement revealed the average frequency of AI ranged from 0.13 (+/- 0.11) in the < 25% group to 0.17 (+/- 0.13) in LNs with >= 75% tumor burden. The range of AI in both the < 25% and > 75% replacement group was 0.00-0.48. Allelic losses at chromosomal regions 1p36.1-36.2, 5q21.1-21.3, 6q15, 10q23.31-23.33, and 17p13.1 were significantly higher in metastatic LNs with > 75% compared with < 25% tumor burden. Conclusions: In metastatic LNs, levels of AI were not associated with tumor burden, suggesting that accumulation of genetic changes is not coincidental with tumor growth; rather the accumulation of specific genetic changes is a prerequisite to the transformation of disseminated breast cells into metastatic LN tumors. C1 Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. Windber Res Inst, Clin Berast Care Project, Windber, PA USA. RP Callaghan, KA (reprint author), Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. EM karen.callaghan@na.amedd.army.mil NR 36 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD NOV PY 2007 VL 14 IS 11 BP 3125 EP 3132 DI 10.1245/s10434-007-9504-7 PG 8 WC Oncology; Surgery SC Oncology; Surgery GA 221CH UT WOS:000250204500014 PM 17653592 ER PT J AU Li, Q Ayers, PD Anderson, AB AF Li, Q. Ayers, P. D. Anderson, A. B. TI Effects of vehicle speed and turning radius of off-road vehicles on terrain impact severity SO APPLIED ENGINEERING IN AGRICULTURE LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Society-of-Agricultural-and-Biological-Engineers CY NOV 09-12, 2005 CL Univ Wisconsin-Madison, Madison, WI HO Univ Wisconsin-Madison DE terrain; impact severity; off-road vehicle; turning radius; speed; interaction ID SOIL PHYSICAL-PROPERTIES; VEGETATION; DEFORMATION; STRESSES AB Off-road vehicles can compact soil, remove vegetation cover, and increase soil erosion. The main objective of this study was to determine the effects of vehicle dynamic parameters on terrain impact. Field tests of a wheeled vehicle at Fort Lewis, Washington, and a tracked vehicle at Fort Riley, Kansas, were conducted. In order to get a wide range of turning radii along with vehicle speed information, the vehicles were operated in a spiral pattern at both high speed and low speed in the field. Terrain impact severity was evaluated along the spirals based on initial impact guidelines. Dynamic parameters of the vehicles were derived from a GPS unit. Terrain impact severity increased as the vehicle turning radius decreased. At a fixed small turning radius, an increase of speed of the wheeled vehicle resulted in a sharp increase in the terrain impact severity. For the tracked vehicle turning at a fixed turning radius, the increase in speed had little effect on the terrain impact severity. Based on the statistical analysis, empirical models of terrain impact were proposed separately for wheeled vehicles and tracked vehicles. C1 [Li, Q.; Ayers, P. D.] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA. [Anderson, A. B.] USA, ERDC, CERL, Champaign, IL USA. RP Ayers, PD (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, EJ Chapman Dr, Knoxville, TN 37996 USA. EM ayers@utk.edu RI Li, Qinghe/D-6747-2011 NR 24 TC 0 Z9 1 U1 0 U2 1 PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS PI ST JOSEPH PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA SN 0883-8542 J9 APPL ENG AGRIC JI Appl. Eng. Agric. PD NOV PY 2007 VL 23 IS 6 BP 701 EP 708 PG 8 WC Agricultural Engineering SC Agriculture GA 242FO UT WOS:000251710100001 ER PT J AU Warren, RE Vanderbeek, RG AF Warren, Russell E. Vanderbeek, Richard G. TI Online estimation of vapor path-integrated concentration and absorptivity using multiwavelength differential absorption lidar SO APPLIED OPTICS LA English DT Article ID ALGORITHM AB Differential absorption lidar data processing traditionally assumes knowledge of the spectral dependence of the absorptivity coefficients. While this is sometimes a good assumption, it is often not in complicated collection environments where the material present is ambiguous. We present an alternative approach that estimates the vapor path-integrated concentration (CL) and absorptivity (rho) in parallel by a processor capable of online implementation. The algorithm is based on an extended Kalman filter (EKF) for CL and a sequential maximum likelihood estimator for rho. The state model parameters of the EKF are also estimated sequentially together with CL and rho. The approach is illustrated on simulated and real topographic backscatter lidar data collected by the Edgewood Chemical Biological Center. (C) 2007 Optical Society of America. C1 EO Stat Inc, Chapel Hill, NC 27517 USA. USA, Edgewood Chem Biol Ctr, AMSRD,ECB,RT,DL, Aberdeen Proving Ground, MD 21010 USA. RP Warren, RE (reprint author), EO Stat Inc, 10010 Vail Dr, Chapel Hill, NC 27517 USA. NR 18 TC 3 Z9 3 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2007 VL 46 IS 31 BP 7579 EP 7586 DI 10.1364/AO.46.007579 PG 8 WC Optics SC Optics GA 237DV UT WOS:000251354500001 PM 17972999 ER PT J AU Ingram, JM Fountain, AW AF Ingram, John M. Fountain, Augustus W., III TI Development of a thermal evaporation cell for gas-phase infrared absorption spectroscopy of compounds with low volatility SO APPLIED SPECTROSCOPY LA English DT Article DE infrared spectroscopy; gas cell; chemical warfare agents AB To facilitate in-depth hazard prediction models, we must understand the spectral properties of expulsion plumes from conventional weapon attacks. Precise data on the spectral absorption of three chemical weapon agent simulants, in the infrared regime, are required to properly determine the mass of simulant in expulsion plumes from field demonstrations and small scale tests. Data for triethyl phosphate (a Soman simulant), triethyl phosphite (a Sarin simulant), and tributyl phosphate (a VX simulant) are presented. A thermal evaporation cell was designed and built that incorporated features that are not commercially available. C1 US Mil Acad, Photon Res Ctr, Dept Chem, West Point, NY 10996 USA. RP Fountain, AW (reprint author), US Mil Acad, Photon Res Ctr, Dept Chem, West Point, NY 10996 USA. EM augustus.w.fountain@us.army.mil NR 5 TC 4 Z9 4 U1 0 U2 4 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD NOV PY 2007 VL 61 IS 11 BP 1254 EP 1258 DI 10.1366/000370207782596978 PG 5 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 230PH UT WOS:000250887900018 PM 18028706 ER PT J AU Engler, RJM Klote, M Nelson, MR AF Engler, Renata J. M. Klote, Mary Nelson, Michael R. TI Optic neuritis and vaccination investigation: Failure to consider significant sex differences and multiple vaccine combinations SO ARCHIVES OF NEUROLOGY LA English DT Letter C1 Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Washington, DC 20012 USA. Walter Reed Army Med Ctr, Allergy Immunol Dept, Washington, DC 20012 USA. RP Engler, RJM (reprint author), Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, POB 59606, Washington, DC 20012 USA. EM renata.engler@amedd.army.mil NR 3 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD NOV PY 2007 VL 64 IS 11 BP 1673 EP 1674 DI 10.1001/archneur.64.11.1673 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA 229YZ UT WOS:000250843800019 PM 17998455 ER PT J AU Brininger, MAJTL Rogers, JC Holm, MB Baker, NA Li, ZM Goitz, RJ AF Brininger, M. A. J. Teresa L. Rogers, Joan C. Holm, Margo B. Baker, Nancy A. Li, Zong-Ming Goitz, Robert J. TI Efficacy of a fabricated customized splint and tendon and nerve gliding exercises for the treatment of carpal tunnel syndrome: A Randomized controlled trial SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE carpal tunnel syndrome; rehabilitation; splints; treatment outcome ID LUMBRICAL MUSCLE INCURSION; GENERAL-POPULATION; HAND; PREVALENCE; SYMPTOMS; PRESSURE; SURGERY; QUESTIONNAIRE; DISPLACEMENT; WRIST AB Brininger TL, Rogers JC, Holm MB, Baker NA, Li Z-M, Goitz RJ. Efficacy of a fabricated customized splint and tendon and nerve gliding exercises for the treatment of carpal tunnel syndrome: a randomized controlled trial. Arch Phys Med Rehabil 2007;88:1429-35. Objective: To compare the effects of a neutral wrist and metacarpophalangeal (MCP) splint with a wrist cock-up splint, with and without exercises, for the treatment of carpal tunnel syndrome (CTS). Design: A 2x2x3 randomized factorial design with 3 main factors: splint (neutral wrist and MCP and wrist cock-up), exercise (exercises, no exercise), and time (baseline, 4wk, 8wk). Setting: Subjects were evaluated in an outpatient hand therapy clinic. Participants: Sixty-one subjects with mild to moderate CTS; 51 subjects completed the study. Interventions: There were 4 groups: the neutral wrist and MCP group and the neutral wrist and MCP-exercise group received fabricated customized splints that supported the wrist and MCP joints; the wrist cock-up group and the wrist cock-up-exercise group received wrist cock-up splints. The neutral wrist and MCP-exercise and wrist cock-up-exercise groups also received tendon and nerve gliding exercises and were instructed to perform exercises 3 times a day. All subjects were instructed to wear the assigned splint every night for 4 weeks. Main Outcome Measures: We used the CTS Symptom Severity Scale (SSS) and the Functional Status Scale (FSS) to assess CTS symptoms and functional status. Results: Analysis of variance showed a significant main effect for splint and time on the SSS (P<.001, P=.014) and FSS (P<.001, P=.029), respectively. There were no interaction effects. Conclusions: Our results validate the use of wrist splints for the treatment of CTS, and suggest that a splint that Supports the wrist and MCP joints in neutral may be more effective than a wrist cock-up splint. C1 Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Occupat Therapy, Pittsburgh, PA USA. Univ Pittsburgh, Med Ctr, Hand Res Lab, Pittsburgh, PA USA. Univ Pittsburgh, Med Ctr, Dept Orthoped Surg, Pittsburgh, PA USA. RP Brininger, MAJTL (reprint author), USA, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM Teresa.Brininger@us.army.mil NR 36 TC 12 Z9 12 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2007 VL 88 IS 11 BP 1429 EP 1435 DI 10.1016/j.apnir.2007.07.019 PG 7 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 229AT UT WOS:000250774400009 ER PT J AU Claybaugh, JR Lin, YC Schafstall, HG Bennett, PB AF Claybaugh, John R. Lin, Yu-Chong Schafstall, Heinrich G. Bennett, Peter B. TI Cardiovascular and endocrine responses to 90 degrees tilt during a 35-day saturation dive to 46 and 37 ATA SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE hyperbaric diuresis; aldosterone; atrial natriuretic peptide; plasma renin activity; vasopressin; orthostatic hypotension ID SEADRAGON-VI; ANTIDIURETIC-HORMONE; NEGATIVE-PRESSURE; RENAL RESPONSES; URINE FLOW; 31-ATA; VASOPRESSIN; EXCRETION; DIURESIS; RENIN AB Introduction: Hyperbaria-induced diuresis is accompanied by decreased basal and stimulated release of arginine vasopressin (AVP) and decreased blood volume possibly contributing to the reported orthostatic intolerance. Since hyperosmolality is not a consistent finding, the explanation of blood volume reduction at hyperbaria must involve an osmotic component to the diuresis. Investigations of a possible involvement of atrial natriuretic peptide (ANP) to the hyperbaric diuresis have revealed mixed results. Methods: Urinary excretion of electrolytes, AVP and aldosterone were measured in four male subjects studied at I atmosphere absolute (ATA) and at 46 and 37 ATA (0.5 atmospheres pressure 02: 5% N-2: remainder He) during a 35-d saturation dive. Also, the supine and 90 degrees tilt-stimulated plasma levels of AVP, plasma renin activity (PRA), and aldosterone, and the suppressed responses of ANP and the cardiovascular responses to tilt were determined at these pressures. Results: Tilt-stimulated levels of PRA were increased two- to threefold and the AVP response was eliminated throughout hyperbaria, except in two episodes of tilt-induced syncope where AVP was elevated 10- to 20-fold. This pattern supports most previous reports. Contrary to some reports, both supine and tilt-suppressed levels of ANP were reduced by about 50% at all three tilt experiments conducted at hyperbaria compared to predive control values. Discussion: These results suggest an altered AN P response at pressures of 37 ATA or greater, which is consistent with an appropriate ANP response to blood volume reduction and further suggest that the hyperbaric diuresis is not dependent on increased ANP. C1 Tripler Army Med Ctr, Dept Clin Invest, MCHK CI, Honolulu, HI 96859 USA. Univ Hawaii, John A Burns Sch Med, Dept Physiol, Honolulu, HI 96822 USA. GKSS Forschungszentrum Geesthacht GmbH, GUSI Underwater Simulator, D-2054 Geesthacht, Germany. Duke Univ, Med Ctr, Hyperbar Ctr, Durham, NC USA. RP Claybaugh, JR (reprint author), Tripler Army Med Ctr, Dept Clin Invest, MCHK CI, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM john.r.claybaugh@us.army.mil NR 33 TC 2 Z9 5 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 2007 VL 78 IS 11 BP 1042 EP 1049 DI 10.3357/ASEM.2014.2007 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 228EX UT WOS:000250711300005 PM 18018436 ER PT J AU Huh, P Kim, SC Kim, Y Wang, Y Singh, J Kumar, J Samuelson, LA Kim, BS Jo, NJ Lee, JO AF Huh, PilHo Kim, Seong-Cheol Kim, Younghoon Wang, Yanping Singh, Jagdeep Kumar, Jayant Samuelson, Lynne A. Kim, Bong-Soo Jo, Nam-Ju Lee, Jang-Oo TI Optical and electrochemical detection of saccharides with poly(aniline-co-3-am nobenzeneboronic acid) prepared from enzymatic polymerization SO BIOMACROMOLECULES LA English DT Article ID BORONIC ACID; AFFINITY-CHROMATOGRAPHY; CONDUCTING POLYANILINE; INTESTINAL GLUCOSE; FLUORESCENT-PROBE; RENAL GLYCOSURIA; DIABETIC RATS; POLYMERS; SENSORS; BINDING AB Boronic acid-based sensors for saccharides have been developed via biocatalysis. The self-doped copolymer of poly(aniline-co-3-aminobenzeneboronic acid) [poly(aniline-co-AB)], with various mole ratios of two components, was synthesized by oxidative enzymatic polymerization using a natural biocatalyst such as horseradish peroxidase together with an anionic polyelectrolyte template (sulfonated polystyrene) under mild conditions (pH 4.5). Poly(aniline-co-AB), having an aniline boronic acid-to-aniline ratio of 1:2 on average, gave rise to a green doped polymer with absorption maxima at 745 nm. The potentiometric detection of saccharides using poly (aniline-co-AB) is presented. Characteristics of both transient and steady-state response associated with the complex formation of poly(aniline-co-AB) with various saccharides were monitored by UV-vis spectroscopy and cyclic voltammetry (CV). The results obtained from UV-vis spectroscopy and CV show that the sensitivity of enzymatically synthesized water-soluble poly(aniline-co-AB) for various saccharides was improved significantly compared to the chemically synthesized counterpart. A possible mechanism for the sensitive detection of sugar molecules by boronic acid is proposed on the basis of UV-vis and IR spectrophotometry, and four-point probe conductivity measurements. C1 USA, Natick Soldier Dev & Engn Ctr, Natick, MA 01760 USA. Univ Massachusetts, Ctr Adv Mat, Dept Chem & Phys, Polymer Sci Program, Lowell, MA 01854 USA. Pusan Natl Univ, Dept Polymer Sci & Engn, Pusan 609735, South Korea. RP Kumar, J (reprint author), USA, Natick Soldier Dev & Engn Ctr, Natick, MA 01760 USA. EM Jayant_kumar@uml.edu; Lynne.Samuelson@us.army.mil; leejo@pusan.ac.kr NR 48 TC 23 Z9 25 U1 0 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1525-7797 J9 BIOMACROMOLECULES JI Biomacromolecules PD NOV PY 2007 VL 8 IS 11 BP 3602 EP 3607 DI 10.1021/bm070421+ PG 6 WC Biochemistry & Molecular Biology; Chemistry, Organic; Polymer Science SC Biochemistry & Molecular Biology; Chemistry; Polymer Science GA 231PA UT WOS:000250960300041 PM 17918994 ER PT J AU Cancio, LC Kuwa, T Matsui, K Drew, GA Galvez, E Sandoval, LL Jordan, BS AF Cancio, Leopoldo C. Kuwa, Toshiyuki Matsui, Kotaro Drew, Guy A. Galvez, Eleuterio, Jr. Sandoval, Laura Lisa Jordan, Bryan S. TI Intestinal and gastric tonometry during experimental burn shock SO BURNS LA English DT Article DE burns; small intestine; gastric mucosa; intestinal mucosa; shock ID ABDOMINAL COMPARTMENT SYNDROME; HEMORRHAGIC-SHOCK; BASE DEFICIT; CRITICALLY-ILL; SPLANCHNIC PERFUSION; FLUID RESUSCITATION; PCO(2) DIFFERENCE; THERMAL-INJURY; INTRAMURAL PH; MAJOR BURNS AB Introduction: The occurrence of organ failure following thermal injury, despite restoration of hemodynamic parameters and urine output during resuscitation, has led to efforts to measure end-organ perfusion. The purpose of this 24-h study was to evaluate the utility of gastrointestinal (GI) tonometry during burn shock and resuscitation. Methods: Male swine (n = 11, 23.3 +/- 0.9 kg) were anesthetized with ketamine and propofol. A 70% full thickness burn was caused by immersion in 97 degrees C water for 30 s. Resuscitation with lactated Ringer's, 4 ml/kg/% burn, was begun at hour 6 and titrated to urine output (UO). Arterial blood gases and pulmonary artery catheter data were measured every 6 h. Gastric and ileal regional PCO2 (PrCO2) were measured continuously by air tonometry, and the gastric and ileal intramucosal pH (pHi) and PCO2 gap (PrCO2 - PaCO2) were calculated every 6 h. Results: Gastric pHi, ileal PrCO2, ileal pHi, and ileal PCO2 gap (but not gastric PrCO2 or PCO2 gap) all decreased with shock and were restored to baseline levels by resuscitation. Changes in ileal PrCO2 were of greater magnitude and demonstrated decreased variability than those in gastric PrCO2. Conclusions: In this model, ileal tonometry outperformed gastric tonometry during burn shock and resuscitation. (C) 2006 Elsevier Ltd and ISBI. All rights reserved. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Hyogo Prefectural Nishinomiya Hosp, Trauma & Crit Care Ctr, Nishinomiya, Hyogo, Japan. Showa Univ Hosp, Tokyo, Japan. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM Lee.Cancio@amedd.army.mil NR 40 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD NOV PY 2007 VL 33 IS 7 BP 879 EP 884 DI 10.1016/j.burns.2006.11.013 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 223HU UT WOS:000250361600010 PM 17532145 ER PT J AU Punglia, RS Cullen, J McLeod, DG Chen, Y D'Amico, AV AF Punglia, Rinaa S. Cullen, Jennifer McLeod, David G. Chen, Yongmei D'Amico, Anthony V. TI Prostate-specific antigen velocity and the detection of Gleason score 7 to 10 prostate cancer SO CANCER LA English DT Article DE cancer detection; Gleason score; prostate cancer; prostate-specific antigen ID RADICAL PROSTATECTOMY; PSA VELOCITY; RISK; DISEASE; DEATH AB BACKGROUND. An increasing prostate-specific antigen (PSA) velocity is associated with a shorter survival after local therapy for prostate cancer. In this study, the authors evaluated whether PSA velocity was associated with prostate cancer detection and grade at diagnosis after adjusting for established predictors. METHODS. Between January 1989 and December 2003, 914 men who had PSA levels >= 4 ng/mL were identified by using the Center for Prostate Disease Research (CPDR) multicenter national database, including 541 men who were diagnosed with prostate cancer. Multivariable logistic regression analyses were performed that included continuous variables (PSA velocity and level, number of prior negative biopsies, and age) along with categorical variables (ethnicity and family history) were used to identify the factors associated with prostate cancer detection and grade. RESULTS. An increasing PSA velocity was associated with Gleason scores from 7 to 10 versus Gleason scores form 2 to 6 or no cancer (adjusted odds ratio [OR], 1.04 ng/mL per year; 95% confidence interval [95% CI], 1.003-1.085 ng/mL per year; P =.035). This finding was not evident in patients who had prostate cancers with Gleason scores between 2 and 6 or for any prostate cancer. PSA level was associated with the detection of any prostate cancer (OR, 1.06 ng/mL; 95% Cl, 1.03-1.10 ng/mL; P =.004) and Gleason score <= 6 prostate cancer (OR, 1.06 ng/ mL; 95% Cl, 1.02-1.10 ng/mL; P =.0027); however, in the presence of PSA velocity, PSA no longer remained independently predictive for high-grade prostate cancer (OR, 1.01 ng/mL; 95% Cl, 0.98-1.04 ng/mL; P =.45) after adjusting for established predictors. CONCLUSIONS. PSA velocity enhanced the detection of high-grade cancer in men who had PSA levels > 4 ng/mL. These findings, in conjunction with life expectancy, may be used when deciding which men should not be recommended for prostate biopsy despite a PSA level > 4 ng/mL. C1 Dana Farber Canc Inst, Boston, MA 02115 USA. Brigham & Womens Hosp, Dept Radiat Oncol, Boston, MA 02115 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Rockville, MD USA. Ctr Prostate Dis Res, Rockville, MD USA. Walter Reed Army Med Ctr, Dept Urol, Bethesda, MD USA. RP Punglia, RS (reprint author), Dana Farber Canc Inst, Smith 274,44 Binney St, Boston, MA 02115 USA. EM rpunglia@partners.org NR 15 TC 14 Z9 14 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD NOV 1 PY 2007 VL 110 IS 9 BP 1973 EP 1978 DI 10.1002/cncr.23014 PG 6 WC Oncology SC Oncology GA 224CE UT WOS:000250422500012 PM 17886252 ER PT J AU Hamsher, C Smith, AM Dehqanzada, ZA Khoo, S Ponniah, S Peoples, GE Moroni, M AF Hamsher, Carlyle Smith, Anna M. Dehqanzada, Zia A. Khoo, Steven Ponniah, Sathibalan Peoples, George E. Moroni, Maria TI Pattern of serum immunoreactivity against breast cancer cell lysates may predict severity of disease in breast cancer patients SO CANCER IMMUNOLOGY IMMUNOTHERAPY LA English DT Article DE breast cancer; serum antibody; immunoreactivity; tumor cell lysates ID PROTEOMICS-BASED IDENTIFICATION; TUMOR-ANTIGEN; AUTOANTIBODIES; BIOMARKERS; IMMUNITY AB Humoral tumor-specific immunity has been investigated as a potential tool to identify tumor-associated antigens and evaluate cancer diagnosis and prognosis. Using SDS-PAGE and western blotting techniques we investigated the humoral immune response against tumor cell antigens in 36 breast cancer patients, 17 node-positive (NP) and 19 node-negative (NN). As a source of antigens, we prepared protein lysates from four breast cancer cell lines (AU565, BT474, MCF-7 and MDA-MB-231) which in vitro exhibit different features of invasion, estrogen receptor/progesterone receptor status and HER2/neu expression thereby potentially representing mild to aggressive forms of clinical disease. A higher number of immunocomplexes Ag-Ab were formed when serum from NN patients was immunoreacted against lysates from AU565 and MCF-7 in comparison to serum from NP patients (P < 0.01). BT474 cells were not a good antigenic source. MDA-MB-231 cells could not significantly discriminate between NN and NP patients since both groups showed higher amounts of reactivity against the lysate. However, comparative analysis of protein preparations purified from MCF-7 and MDA-MB-231 cells and immunodetected concomitantly with the same serum samples showed that serum from patients with cancers with worse prognosis (stage, nodality, HER2/neu and hormonal status) reacted more intensely to proteins purified from the relatively more invasive cell line MDA-MB-231 compared to MCF-7. These findings suggest that the study of serum antibody reactivity to antigens purified from breast cancer cell lines with different invasive properties should be further investigated for its potential in providing beneficial prognostic information in breast cancer. C1 Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Bethesda, MD 20889 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Lab, Bethesda, MD 20814 USA. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. RP Moroni, M (reprint author), Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, 8901 Wisconsin Ave,Bldg 42, Bethesda, MD 20889 USA. EM moroni@afrri.usuhs.mil NR 20 TC 2 Z9 2 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0340-7004 J9 CANCER IMMUNOL IMMUN JI Cancer Immunol. Immunother. PD NOV PY 2007 VL 56 IS 11 BP 1711 EP 1721 DI 10.1007/s00262-007-0314-3 PG 11 WC Oncology; Immunology SC Oncology; Immunology GA 204BI UT WOS:000249017400003 PM 17440722 ER PT J AU Dave, JR Connors, RA Genovese, RE Whipple, RA Chen, RW DeFord, SM Moran, AV Tortella, EC AF Dave, J. R. Connors, R. A. Genovese, R. E. Whipple, R. A. Chen, R. W. DeFord, S. M. Moran, A. V. Tortella, E. C. TI DNA fragmentation in leukocytes following repeated low dose sarin exposure in guinea pigs SO CELLULAR AND MOLECULAR LIFE SCIENCES LA English DT Article DE chemical warfare agents; sarin; comet assay; DNA fragmentation; guinea pigs; lymphocytes; brain; parietal cortex ID INBRED BALB/C MICE; SOMAN; RATS; INVOLVEMENT; INHALATION; SYSTEM AB The objective of this study was to determine levels of DNA fragmentation in blood leukocytes and parietal cortex from guinea pigs following repeated low-level exposure to the chemical warfare nerve agent (CWNA) sarin. Guinea pigs were injected (s.c.) once a day for 10 days with saline, or 0.1, 0.2, or 0.4 LD50 (50% mean lethal dose) sarin dissolved in sterile physiological saline. Blood and parietal cortex was collected after injection at 0, 3, and 17 days recovery and evaluated for DNA fragmentation using single-cell gel electrophoresis (Comet assay). Cells were imaged using comet analysis software and three parameters of DNA fragmentation measured: tail length, percent DNA in the tail, and tail moment arm. Repeated low-dose exposure to sarin produced a dose-dependent response in leukocytes at 0 and 3 days post-exposure. There was a significant increase in all measures of DNA fragmentation at 0.2 and 0.4 LD50, but not at 0.1 LD50. There was no significant increase in DNA fragmentation in any of the groups at 17 days post-exposure. Sarin did not produce a systematic dose-dependent response in parietal cortex at any of the time points. However, significant increases in DNA fragmentation at 0.1 and 0.4 LD50 were observed at 0 and 3 days post-exposure. All measures of DNA fragmentation in both leukocytes and neurons returned to control levels by 17 days post-exposure, indicating a small and non-persistent increase in DNA fragmentation following repeated low-level exposure to sarin. C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. USA, Med Res Inst Chem Def, Drug Assessment Div, Aberdeen Proving Ground, MD 21010 USA. RP Dave, JR (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. NR 19 TC 2 Z9 2 U1 0 U2 4 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND SN 1420-682X J9 CELL MOL LIFE SCI JI Cell. Mol. Life Sci. PD NOV PY 2007 VL 64 IS 21 BP 2823 EP 2828 DI 10.1007/s00018-007-7339-9 PG 6 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 234BP UT WOS:000251136000009 PM 17917701 ER PT J AU Scala, JJ Ulven, CA Orlicki, JA Jain, R Palmese, GR Vaidya, UK Sands, JM AF La Scala, John J. Ulven, Chad A. Orlicki, Joshua A. Jain, Rahul Palmese, Giuseppe R. Vaidya, Uday K. Sands, James M. TI Emission modeling of styrene from vinyl ester resins SO CLEAN TECHNOLOGIES AND ENVIRONMENTAL POLICY LA English DT Article DE Diffusion; Evaporation; Modeling; Styrene; Vinyl ester ID WET COATING MATERIALS; SOLVENT SYSTEMS; CURE KINETICS; DIFFUSION; POLYMER; TEMPERATURE; MONOMERS AB The use of vinyl ester (VE) resins in the composites industry has increased in the last decade, and the trend is projected to continue. Styrene is a commonly used co-monomer in VE resins, which acts as a reactive diluent and is required in many liquid molding methods to reduce viscosity and increase gel time. The emission rate of styrene from VE resins is affected by various parameters, including styrene content, temperature, and resin surface-to-volume ratio. This study experimentally measured the effect of these parameters on styrene emission rates from VE resins. It was observed that the emission rate and amount of styrene decreased with decreasing surface-to-volume ratio, temperature, and styrene content. It is also shown that diffusion coefficient and evaporation coefficient of styrene have an exponential relationship with temperature, while they remained constant with initial styrene concentration and aspect ratio. Emission rate and amount decreased with increasing resin initial depth to radius ratio. The emission profiles were self-similar for different aspect ratios and were scaled by the ratio of the instantaneous sample depth to radius. Overall, the effect of these various parameters on the emission profile can be accurately modeled using a modification of a simple one-dimensional diffusion model based on the Crank solution to diffusion through a planar sheet. C1 [La Scala, John J.; Orlicki, Joshua A.; Sands, James M.] USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. [Ulven, Chad A.; Jain, Rahul; Vaidya, Uday K.] Univ Alabama, Dept Mat Sci & Engn, Birmingham, AL 35294 USA. [Ulven, Chad A.] N Dakota State Univ, Dept Mech Engn, Fargo, ND 58105 USA. [Palmese, Giuseppe R.] Drexel Univ, Dept Biol & Chem Engn, Philadelphia, PA 19104 USA. RP Scala, JJ (reprint author), USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM jlascala@arl.army.mil FU Strategic Environmental Research and Development Program (SERDP) project [PP-1271]; Environmental Security Technology Certification Program (ESTCP) [WP-0617] FX The authors thank the support for this work provided by Strategic Environmental Research and Development Program (SERDP) project PP-1271 and continued support from Environmental Security Technology Certification Program (ESTCP) WP-0617. NR 37 TC 8 Z9 8 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1618-954X J9 CLEAN TECHNOL ENVIR JI Clean Technol. Environ. Policy PD NOV PY 2007 VL 9 IS 4 BP 265 EP 279 DI 10.1007/s10098-006-0076-1 PG 15 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA 371IV UT WOS:000260825900005 ER PT J AU Blacksell, SD Bell, D Kelley, J Mammen, MP Gibbons, RV Jarman, RG Vaughn, DW Jenjaroen, K Nisalak, A Thongpaseuth, S Vongsouvath, M Davong, V Phouminh, P Phetsouvanh, R Day, NPJ Newton, PN AF Blacksell, Stuart D. Bell, David Kelley, James Mammen, Mammen P., Jr. Gibbons, Robert V. Jarman, Richard G. Vaughn, David W. Jenjaroen, Kemajittra Nisalak, Ananda Thongpaseuth, Soulignasack Vongsouvath, Manivanh Davong, Viengmone Phouminh, Phonelavanh Phetsouvanh, Rattanaphone Day, Nicholas P. J. Newton, Paul N. TI Prospective study to determine accuracy of rapid serological assays for diagnosis of acute dengue virus infection in Laos SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID ANTIBODY; TSUTSUGAMUSHI; RESPONSES; SERUM AB There is an urgent need for accurate and simple dengue virus infection diagnostic assays in limited-resource settings of dengue endemicity, to assist patient management. Using a panel of reference samples (S. D. Blacksell, P. N. Newton, D. Bell, J. Kelley, M. P. Mammen, D. W. Vaughn, V. Wuthiekanun, A. Sungkakum, A. Nisalak, and N. P. Day, Clin. Infect. Dis. 42:1127-1134, 2006), we recently evaluated eihgt commercially available immunochromatographic rapid diagnostic tests (RDTs) designed to detect dengue virus-specific immunoglobulin M (IgM) and/or IgG. We found that 6/8 RDTs had sensitivities of less than 50% (range, 6 to 65%), but specificities were generally high. Here, in conjuction with dengue virus serotyping by reverse transcriptase PCR and in the limited-resource setting of Laos, where dengue virus is endemic, we evaluated the same eight RDTs against a previously validated dengue IgM/IgG enzyme-linked immunosorbent assay for diagnosis of acute dengue virus infection. Paired serum samples were collected from 87 patients, of whom 38 had confirmed dengue virus infections (4 had primary infections, 33 had secondary infections, and 1 had an infection of indeterminate status). RDT sensitivity was low, with 7/8 RDTs having admission sample sensitivities of less than 20% (range, 4 to 26%). The majority (6/8) of the RDTs, demonstrated high specificity (>95%). Kappa statistic values ranged from 6 to 54% for the RDTs, demonstrating poor to moderate variation between three operators. No RDT adequately differentiated between primary and secondary dengue virus infections. The findings of this study suggest that currently available RDTs based on the detection of IgM antibodies for the diagnosis of acute dengue virus infections are unlikely to be useful for patient management. C1 Mahosot Hosp, Microbiol Lab, Wellcome Trust Mahosot Hosp Oxford Trop Med, Viangchan, Laos. Univ Oxford, Churchill Hosp, Ctr Trop Med, Nuffield Dept Clin Med, Oxford, England. Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand. WHO, Reg Off Westen Pacific, Manila, Philippines. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. USA, Med Res & Mat Command, Mil Infect Dis Res Program, Ft Detrick, MD USA. RP Blacksell, SD (reprint author), Mahosot Hosp, Microbiol Lab, Wellcome Trust Mahosot Hosp Oxford Trop Med, Viangchan, Laos. EM stuart@tropmedres.ac; Paul@tropmedres.ac OI Blacksell, Stuart/0000-0001-6576-726X FU Wellcome Trust NR 16 TC 20 Z9 21 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD NOV PY 2007 VL 14 IS 11 BP 1458 EP 1464 DI 10.1128/CVI.00482-06 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233YI UT WOS:000251125800011 PM 17715330 ER PT J AU Morefield, GL Hawkins, LD Ishizaka, ST Kissner, TL Ulrich, RG AF Morefield, Garry L. Hawkins, Lynn D. Ishizaka, Sally T. Kissner, Teri L. Ulrich, Robert G. TI Synthetic Toll-like receptor 4 agonist enhances vaccine efficacy in an experimental model of toxic shock syndrome SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID TOLL-LIKE RECEPTORS; BACTERIAL SUPERANTIGENS; IMMUNE-RESPONSE; HUMAN MONOCYTES; MIXED TH1/TH2; MICE; IMMUNIZATION; ENDOTOXIN; GENE AB The development of new protein subunit vaccines has stimulated the search for improved adjuvants to replace traditional aluminum-containing products. We investigated the adjuvant effects of a synthetic Toll-like receptor 4 (TLR4) agonist on vaccine efficacy in an experimental model of toxic shock syndrome. The TLR4 agonist E6020 has a simplified structure consisting of a hexa-acylated acyclic backbone. The vaccine examined is a recombinantly attenuated form of staphylococcal enterotoxin B (STEBVax). Using cells stably transfected with TLRs, E6020 transduced signals only through TLR4, suggesting monospecificity, while Escherichia coli 055:B5 lipopolysaccharide activated both the TLR2/6 heterodimer and TLR4. Coadministration of E6020 with STEBVax, by the intramuscular or intranasal route, induced significant levels of immunoglobulin G (IgG) in BALB/c mice. Further, increased IgG production resulted from the combination of E6020 with aluminum hydroxide adjuvant (AH). The antibody response to the vaccine coadministered with E6020 was a mixed Th1/Th2 response, as opposed to the Th2-biased response obtained with AH. Mice vaccinated with STEBVax coadministered with AH, TLR4 agonists, or a combination of both adjuvants were protected from toxic shock Our data demonstrate the effectiveness of the synthetic TLR4 agonist E6020 as an alternative adjuvant for protein subunit vaccines that may also be used in combination with traditional aluminum-containing adjuvants. C1 USA, Med Res Inst Infect Dis, Lab Mol Immunol, Frederick, MD 21702 USA. Eisai Res Inst, Andover, MA 01887 USA. RP Ulrich, RG (reprint author), USA, Med Res Inst Infect Dis, Lab Mol Immunol, Frederick, MD 21702 USA. EM ulrich@ncifcrf.gov NR 25 TC 26 Z9 28 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD NOV PY 2007 VL 14 IS 11 BP 1499 EP 1504 DI 10.1128/CVI.00153-07 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 233YI UT WOS:000251125800016 PM 17715328 ER PT J AU Larsow, SP Bowers, SP Palekar, NA Ward, JA Pulcini, JP Harrison, SA AF Larsow, Steven P. Bowers, Steven P. Palekar, Nicole A. Ward, John A. Pulcini, Joseph P. Harrison, Stephen A. TI Histopathologic variability between the right and left lobes of the liver in morbidly obese patients undergoing roux-en-Y bypass SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article ID SAMPLING VARIABILITY; UNITED-STATES; HEPATITIS-C; DISEASE; BIOPSY; PREVALENCE; FIBROSIS; IMPACT AB Background & Aims: Nonalcoholic fatty liver disease (NAFLD) has been shown to occur in > 90% of significantly obese patients. At present, diagnosis of the more severe form of NAFLD, nonalcoholic steatohepatitis (NASH), requires a liver biopsy. Conflicting data exist on the degree of sampling variability seen with percutaneous liver biopsy. Our aim was to assess for significant regional differences in histopathology between the right and left lobes of the liver in morbidly obese patients undergoing bariatric surgery. Methods: Morbidly obese patients undergoing bariatric surgery at Wilford Hall Medical Center were eligible for study enrollment. Patients with chronic liver disease other than NAFLD were excluded. All patients underwent intra-operative liver biopsy, one from the right lobe and one from the left lobe, with a 14-gauge Tru-cut biopsy needle. Histopathologic features of NAFLD were compared by a hepatopathologist who examined biopsy specimens from the 2 hepatic lobes and was blinded to patient identification and site of origin of biopsy. Agreement between the 2 biopsy specimens was assessed by using the kappa coefficient. Results: Forty-three patients (predominantly female) with body mass index median of 46.2 kg/m(2) were enrolled. Agreement for steatosis was 93% (kappa = 0.91), inflammation 74% (kappa = 0.58), ballooning necrosis 84% (kappa = 0.73), fibrosis 98% (kappa=0.96), and for the NAFLD activity score :5 was 93% (kappa = 0.83). Conclusions: Minimal variability was found for steatosis, NAFLD activity score >= 5, and fibrosis in samples of liver obtained from the right and left lobes of the liver in a group of morbidly obese, predominately female patients undergoing bariatric surgery. Histopathologic findings of necroinflammation appear to have the greatest degree of sampling variability. In contrast with previously published data, excellent agreement was seen for fibrosis in biopsy specimens obtained at surgery from right and left lobes of the liver. C1 Wilford Hall USAF Med Ctr, Div Gastroenterol & Hepatol, San Antonio, TX 78236 USA. Wilford Hall USAF Med Ctr, Dept Surg, San Antonio, TX 78236 USA. Wilford Hall USAF Med Ctr, Dept Clin Invest, San Antonio, TX 78236 USA. Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil NR 10 TC 38 Z9 38 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD NOV PY 2007 VL 5 IS 11 BP 1329 EP 1332 DI 10.1016/j.cgh.2007.06.005 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 231KF UT WOS:000250944900017 PM 17702661 ER PT J AU Davis, LP Henry, CJ Campbell, RL Ward, WA AF Davis, Larry P. Henry, Cray J. Campbell, Roy L., Jr. Ward, William A., Jr. TI High-Performance Computing for Defense SO COMPUTING IN SCIENCE & ENGINEERING LA English DT Article AB The US Department of Defense High Performance Computing Modernization Program has developed an evaluation process that combines qualitative usability factors with quantitative performance and price-per-performance factors to determine which HPC systems to acquire in its annual modernization process. C1 Louisiana State Univ, US Dept Defense, High Performance Comput Modernizat Program, Baton Rouge, LA 70803 USA. Univ Mississippi, USA, Res Lab, University, MS 38677 USA. Purdue Univ, USA, Engn Res & Dev Ctr, W Lafayette, IN 47907 USA. Tulane Univ, US Dept Defense, High Performance Comput Modernizat Program, New Orleans, LA 70118 USA. RP Davis, LP (reprint author), Louisiana State Univ, US Dept Defense, High Performance Comput Modernizat Program, Baton Rouge, LA 70803 USA. EM larryd@hpcmo.hpc.mil; cray@hpcmo.hpc.mil; rcampbell@arl.army.mil; william.a.ward.jr@erdc.usace.army.mil NR 15 TC 0 Z9 0 U1 1 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1521-9615 J9 COMPUT SCI ENG JI Comput. Sci. Eng. PD NOV-DEC PY 2007 VL 9 IS 6 BP 35 EP 44 DI 10.1109/MCSE.2007.115 PG 10 WC Computer Science, Interdisciplinary Applications SC Computer Science GA 221TB UT WOS:000250249100010 ER PT J AU Spinella, PC Perkins, JG Grathwohl, KW Repine, T Beekley, AC Sebesta, J Jenkins, D Azarow, K Holcomb, JB AF Spinella, Philip C. Perkins, Jeremy G. Grathwohl, Kurt W. Repine, Thomas Beekley, Alec C. Sebesta, James Jenkins, Donald Azarow, Kenneth Holcomb, John B. CA 31st Combat Support Hosp Res Worki TI Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital SO CRITICAL CARE MEDICINE LA English DT Article DE trauma; transfusion; hemorrhage; coagulopathy; war; whole blood ID MULTIPLE ORGAN FAILURE; CRITICALLY-ILL; MASSIVE TRANSFUSION; OXYGEN-CONSUMPTION; STORED-BLOOD; STORAGE; SURGERY; SEPSIS; TRAUMA; RESUSCITATION AB Objective. Fresh whole blood (FWB) and red blood cells (RBCs) are transfused to injured casualties in combat support hospitals. We evaluated the risks of FWB and RBCs transfused to combat-related casualties. Design: Retrospective chart review. Setting. Deployed U.S. Army combat support hospitals. Subjects. Donors of FWB and recipients of FWB and RBCs. Measurements and Results: The storage age of RBCs at transfusion was measured as an indicator of overall risk associated with the storage lesion of RBCs between January 2004 and December 2004 at one combat support hospital. Between April 2004 and December 2004, FWB was prescreened only at one combat support hospital for human immunodeficiency virus, hepatitis C virus, and hepatitis B surface antigen before transfusion. To estimate the general incidence of infectious agent contamination in FWB units, samples collected between May 2001 and February 2006 were tested retrospectively for human immunodeficiency virus, hepatitis B surface antigen, hepatitis C virus, and human lymphotropic virus. Results were compared between FWB samples prescreened and not prescreened for infectious agents before transfusion. At one combat support hospital in 2004, 87 patents were transfused 545 units of FWB and 685 patients were transfused 5,294 units of RBCs with mean age at transfusion of 33 days (+/- 6 days). Retrospective testing of 2,831 samples from FWB donor Units transfused in Iraq and Afghanistan between May 2003 and February 2006 indicated that three of 2,831 (0.110/6) were positive for hepatitis C virus recombinant immunoblot assay, two of 2,831 (0.07%) were positive for human lymphotropic virus enzyme immunoassay, and none of 2,831 were positive for both human immunodeficiency virus 1/2 and hepatitis B surface antigen by Western blot and neutralization methods, respectively. The differences in the incidence of hepatitis C virus contamination of FWB donor units between those prescreened for hepatitis C virus (zero of 406; 0%) and not prescreened (three of 2,425; 0.12%) were not significant (p =.48). Conclusions: The risk of infectious disease transmission with FWB transfusion can be minimized by rapid screening tests before transfusion. Because of the potential adverse outcomes of transfusing RBCs of increased storage age to combat-related trauma patents, the risks and benefits of FWB transfusions must be balanced with those of transfusing old RBCs in patients with life-threatening traumatic injuries. C1 USA, Inst Surg Res, San Antonio, TX USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Brooke Army Med Ctr, San Antonio, TX USA. William Beaumont Army Med Ctr, El Paso, TX 79920 USA. Madigan Army Med Ctr, Tacoma, WA 98431 USA. Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. Childrens Med Ctr, Hartford, CT USA. EM pspinella@ccmckids.org NR 65 TC 69 Z9 74 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD NOV PY 2007 VL 35 IS 11 BP 2576 EP 2581 DI 10.1097/01.CCM.0000285996.65226.A9 PG 6 WC Critical Care Medicine SC General & Internal Medicine GA 224CN UT WOS:000250423500014 PM 17828033 ER PT J AU Pursifull, NF Morey, AF AF Pursifull, Nathan F. Morey, Allen F. TI Tissue glues and nonsuturing techniques SO CURRENT OPINION IN UROLOGY LA English DT Review DE hemostasis; tissue adhesives; urology ID LAPAROSCOPIC PARTIAL NEPHRECTOMY; TUBELESS PERCUTANEOUS NEPHROLITHOTOMY; RADICAL RETROPUBIC PROSTATECTOMY; MATRIX HEMOSTATIC SEALANT; FIBRIN SEALANT; GELATIN MATRIX; PORCINE MODEL; INITIAL-EXPERIENCE; CYANOACRYLIC GLUE; BOVINE THROMBIN AB Purpose of review This article details the diverse urologic applications of tissue glues and hemostatic agents over the past 3 years in the management of genitourinary injuries, surgical wounds, and complications. Recent findings Biosurgical agents designed to promote tissue adhesion and hemostasis are being increasingly employed across all surgical disciplines. Fibrin sealant is the most widely utilized biosurgical product. Gelatin matrix thrombin has proven to be an efficacious hemostatic agent. Bovine serum albumin-gluataralclehyde is a new, promising tissue glue. Complex reconstructive, oncologic and laparoscopic procedures are those most appropriate for sealant use in urology. Summary Tissue glues and hemostatic agents are effective, safe, and their use is increasing. All urologists should have a working knowledge of these adjuncts. C1 Univ Texas, SW Med Ctr, Dept Urol, Dallas, TX 75390 USA. Brooke Army Med Ctr, Dept Urol, Ft Sam Houston, TX 78234 USA. RP Morey, AF (reprint author), Univ Texas, SW Med Ctr, Dept Urol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM allen.morey@utsouthwestern.edu NR 39 TC 35 Z9 36 U1 1 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0963-0643 J9 CURR OPIN UROL JI Curr. Opin. Urol. PD NOV PY 2007 VL 17 IS 6 BP 396 EP 401 DI 10.1097/MOU.0b013e3282f0d683 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 229LM UT WOS:000250804500004 PM 17921773 ER PT J AU Osswald, S Gurga, A Kellogg, F Cho, K Yushin, G Gogotsi, Y AF Osswald, Sebastian Gurga, Adrian Kellogg, Franklyn Cho, Kyu Yushin, Gleb Gogotsi, Yury TI Plasma pressure compaction of nanodiamond SO DIAMOND AND RELATED MATERIALS LA English DT Article DE nanodiamond; sintering; plasma pressure compaction; agglomeration; Raman spectroscopy ID ONION-LIKE CARBON; DIAMOND; GRAPHITIZATION; TRANSFORMATION; NANOPARTICLES; DETONATION; POWDERS; FILMS; SIZE AB Detonatiton synthesized nanodiamond (ND) was sintered using a Plasma Pressure Compaction (p(2)C) technique. Sintering was performed for 1 min at temperatures between 700 and 1200 degrees C, and for 1-10 min at 900 degrees C under 65 MPa pressure. Structure and composition of the sintered samples were analyzed by X-ray diffraction, transmission electron microscopy and Raman microspectroscopy. The selected sintering conditions prevent excessive graphitization of diamond and allow formation of porous pellets having the density of 1.3-1.6 g/cm(3), hardness > 0.1 GPa and Young's modulus >3 GPa. The sintered ND pellets with porosity of about 50% have mechanical properties sufficient for handling and can be infiltrated to produce ND composites. Published by Elsevier B.V. C1 Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. Drexel Univ, AJ Drexel Nanotechnol Inst, Philadelphia, PA 19104 USA. USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. RP Gogotsi, Y (reprint author), Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. EM Gogotsi@drexel.edu RI Gogotsi, Yury/B-2167-2008; Yushin, Gleb/B-4529-2013 OI Gogotsi, Yury/0000-0001-9423-4032; Yushin, Gleb/0000-0002-3274-9265 NR 32 TC 11 Z9 11 U1 0 U2 10 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-9635 J9 DIAM RELAT MATER JI Diam. Relat. Mat. PD NOV PY 2007 VL 16 IS 11 BP 1967 EP 1973 DI 10.1016/j.diamond.2007.09.012 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA 233XI UT WOS:000251123200013 ER PT J AU Harris, F AF Harris, Fred TI Editorial SO DIGITAL SIGNAL PROCESSING LA English DT Editorial Material C1 San Diego State Univ, San Diego, CA 92182 USA. USA, Res Lab SNHE, Hanscom AFB, MA USA. RP Harris, F (reprint author), San Diego State Univ, San Diego, CA 92182 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1051-2004 J9 DIGIT SIGNAL PROCESS JI Digit. Signal Prog. PD NOV PY 2007 VL 17 IS 6 BP 995 EP 996 DI 10.1016/j.dsp.2007.09.003 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA 228RK UT WOS:000250747100001 ER PT J AU Yang, J Sarkar, TK Antonik, P AF Yang, J. Sarkar, T. K. Antonik, P. TI Applying the Fourier-modified mellin transform (FMMT) to Doppler-distorted waveforms SO DIGITAL SIGNAL PROCESSING LA English DT Article DE Fourier-modified mellin transform; Doppler distortion ID RECOGNITION; REGISTRATION; RESTORATION; SYSTEMS; RADAR AB The magnitude spectrum of a time domain signal has the property of delay-invariance. Similar to the delay-invariance property of the Fourier transform, the Mellin transform has the property of scale-invariance. By combining. these two transforms together one can form the Fourier-Mellin transform that yields a signal representation which is independent of both delay and scale change. Due to the undesired low-pass property of the Mellin transform (MT), the modified Mellin transform (MMT) which is also scale-invariant is applied in our approach. Therefore the Fourier-modified Mellin transform (FMMT) of the original signal and the Doppler-distorted signal will be identical. This signal representation is useful in signal detection and target recognition. Several examples dealing with different waveforms have been simulated to illustrate the applicability of this approach. The performance of the Fourier-modified Mellin transform under different levels of noise in the signal are also illustrated in this paper. (c) 2006 Elsevier Inc. All rights reserved. C1 Syracuse Univ, Dept Elect Engn & Comp Sci, Syracuse, NY 13244 USA. USA, Res Lab, AFRL SNRT, Rome, NY USA. RP Yang, J (reprint author), Syracuse Univ, Dept Elect Engn & Comp Sci, 335 Link Hall, Syracuse, NY 13244 USA. EM jyang14@syr.edu NR 16 TC 4 Z9 4 U1 2 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1051-2004 J9 DIGIT SIGNAL PROCESS JI Digit. Signal Prog. PD NOV PY 2007 VL 17 IS 6 BP 1030 EP 1039 DI 10.1016/j.dsp.2006.06.004 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA 228RK UT WOS:000250747100005 ER PT J AU Serichantalergs, O Dalsgaard, A Bodhidatta, L Krasaesub, S Pitarangs, C Srijan, A Mason, CJ AF Serichantalergs, O. Dalsgaard, A. Bodhidatta, L. Krasaesub, S. Pitarangs, C. Srijan, A. Mason, C. J. TI Emerging fluoroquinolone and macrolide resistance of Campylobacter jejuni and Campylobacter coli isolates and their serotypes in Thai children from 1991 to 2000 SO EPIDEMIOLOGY AND INFECTION LA English DT Article ID THERMOPHILIC CAMPYLOBACTER; ANTIMICROBIAL RESISTANCE; ANTIBIOTIC-RESISTANCE; DIARRHEAL PATHOGENS; IDENTIFICATION; AZITHROMYCIN; TRAVELERS; HUMANS; TRENDS AB This study investigated fluoroquinolone, macrolide resistances and serotype distributions among Campylobacter jejuni and Campylobacter coli isolated from children in Bangkok and rural settings during 1991-2000. Phenotypic identification, serotyping, and susceptibility testing were performed by standard microbiological procedures. The predominant serotypes of C. jejuni were Lior 36, 2 and 4 and of C. coli were Lior 8, 29 and 55. Resistance to nalidixic acid increased significantly during 1991-2000 and the frequency of isolates resistant to both nalidixic acid and ciprofloxacin in Bangkok was significantly greater than in rural settings. In 1996-2000, a significant trend was observed in C. jejuni isolates resistant to ciprofloxacin from Bangkok but not for macrolide resistance from both settings. In summary, fluoroquinolone resistance among C. jejuni and C. coli isolates became widespread in both Bangkok and rural settings in Thailand in the 1990s while widespread resistance to macrolides was undetected. C1 Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. Univ Copenhagen, Fac Life Sci, Dept Vet Pathobiol, DK-1168 Copenhagen, Denmark. RP Serichantalergs, O (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM oralaks@afrims.org OI MASON, CARL/0000-0002-3676-2811 NR 27 TC 23 Z9 24 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD NOV PY 2007 VL 135 IS 8 BP 1299 EP 1306 DI 10.1017/S0950268807008096 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 238ZH UT WOS:000251486600008 PM 17306054 ER PT J AU Feinberg, EC Larsen, FW Wah, RM Alvero, RJ Armstrong, AY AF Feinberg, Eve C. Larsen, Frederick W. Wah, Robert M. Alvero, Ruben J. Armstrong, Alicia Y. TI Economics may not explain Hispanic underutilization of assisted reproductive technology services SO FERTILITY AND STERILITY LA English DT Editorial Material ID OUTCOMES; CARE AB In a lower cost, equal-access-to-care setting, Hispanic use of assisted reproductive technology was less than half of what would have been expected based on patient demographics. Despite this use disparity, there were no significant differences between Hispanic and Caucasian women with regard to infertility diagnoses, assisted reproductive technology cycle parameters, clinical pregnancy rates, live birth rates, spontaneous abortion rates, and implantation rates. C1 Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Natl Inst Hlth, Combined Fed Fellowship Reprod Endocrinol & I, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, WRAMC Assisted Reprod Technol Program, Washington, DC 20307 USA. NICHHD, Reprod Biol & Med Branch, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Univ Colorado, Hlth Sci Ctr, Aurora, CO USA. RP Armstrong, AY (reprint author), NIH, NICHHD, 10 Ctr Dr,MSC 1109,Bldg 10,CRC,1-3140, Bethesda, MD 20892 USA. EM armstroa@mail.nih.gov NR 5 TC 16 Z9 17 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD NOV PY 2007 VL 88 IS 5 BP 1439 EP 1441 DI 10.1016/j.fertnstert.2007.01.031 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 231XA UT WOS:000250981300027 PM 17561005 ER PT J AU Case, FH Brennan, J Chaka, A Dobbs, KD Friend, DG Frurip, D Gordon, PA Moore, J Mountain, RD Olson, J Ross, RB Schiller, M Shen, VK AF Case, Fiona H. Brennan, John Chaka, Anne Dobbs, Kerwin D. Friend, Daniel G. Frurip, David Gordon, Peter A. Moore, Jonathan Mountain, Raymond D. Olson, James Ross, Richard B. Schiller, Martin Shen, Vincent K. TI The third industrial fluid properties simulation challenge SO FLUID PHASE EQUILIBRIA LA English DT Article DE molecular simulation; VLE; phase equilibria; viscosity; statistical mechanics; molecular dynamics; Monte Carlo ID VAPOR-LIQUID-EQUILIBRIA; MOLECULAR-DYNAMICS SIMULATION; HENRYS LAW CONSTANTS; PHASE-EQUILIBRIA; FORCE-FIELD; SHEAR VISCOSITY; COSMO-RS; TRANSFERABLE POTENTIALS; PREDICTION; MIXTURES AB The third industrial fluid properties simulation challenge was held from March to September 2006. As in the previous two events contestants were challenged to predict specific, indutrially relevant, properties of fluid systems. Their efforts were judged based on the agreement of the predicted values with previously unpublished experimental data (provided by researchers at ExxonMobil and DuPont). The focus of this contest was on the transferability of modeling methods-the ability to predict properties for materials that are chemically different, or at different state points, to those used in model parameterization and validation. Nine groups attempted to compute bubble point pressures for mixtures of 1, 1, 1,2,3,3,3heptafluoropropane (HFC-227ea) and ethanol at 343 K, given data for mixtures at 283 K, and given the pure component vapor pressures. They used a range of different techniques including statistical mechanical and molecular simulations-based approaches. Four of the groups were recognized for providing predictions that were significantly more accurate than would be obtained by extrapolation using the NRTL model (the standard engineering approach). Three groups undertook the more challenging "molecular transferability" problem, attempting to predict shear viscosities at two different state points for a range of diols and triols for which little experimental data was available. (C) 2007 Elsevier B.V. All rights reserved. C1 Case Sci, Essex Jct, VT USA. Army Res Lab, Aberdeen Proving Ground, MD USA. NIST, Gaithersburg, MD 20899 USA. DuPont Co Inc, Wilmington, DE USA. NIST, Boulder, CO USA. Dow Chem Co USA, Midland, MI USA. ExxonMobil Co, Annandale, NJ USA. Dow Chem Co USA, Charleston, WV USA. 3M Co, St Paul, MN USA. RP Mountain, RD (reprint author), Case Sci, Essex Jct, VT USA. EM Raymond.Mountain@nist.gov RI Moore, Jonathan/B-8201-2009 NR 54 TC 26 Z9 26 U1 3 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3812 J9 FLUID PHASE EQUILIBR JI Fluid Phase Equilib. PD NOV 1 PY 2007 VL 260 IS 2 BP 153 EP 163 DI 10.1016/j.fluid.2007.08.021 PG 11 WC Thermodynamics; Chemistry, Physical; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA 233FL UT WOS:000251075700001 ER PT J AU Chen, JYC Thropp, JE AF Chen, Jessie Y. C. Thropp, Jennifer E. TI Review of low frame rate effects on human performance SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART A-SYSTEMS AND HUMANS LA English DT Review DE frame rate (FR); human factors; human performance; video quality ID VIRTUAL ENVIRONMENTS; REPRESENTATIONAL MOMENTUM; TELEOPERATOR PERFORMANCE; CONTRAST SENSITIVITY; MULTIMEDIA QUALITY; TASK-PERFORMANCE; DISPLAYS; PERCEPTION; PARAMETERS; RESOLUTION AB In this paper, we conducted a comprehensive survey of the effects of different frame rates (FRs) on human performance and reviewed more than 50 studies and summarized them in the areas of psychomotor performance, perceptual performance, behavioral effects, and subjective perception. Overall, there seems to be strong support for a threshold of around 15 Hz for many tasks, including those that are psychomotor and perceptual in nature. Less impressive yet acceptable performance maybe accomplished at around 10 Hz for many tasks. Subjective reactions to the quality and watchability of videos seem to support rates of 5 Hz, although videos presented at 15 Hz and above are generally more widely preferred. These generalizations regarding superior and acceptable FRs may also be subject to the effects of several moderating factors such as display characteristics, nature of the tasks, viewing condition, additional cues, and user experience. C1 USA, Res Lab, Orlando, FL 32826 USA. United Space Alliance, Kennedy Space Ctr, Cape Canaveral, FL 32899 USA. RP Chen, JYC (reprint author), USA, Res Lab, Orlando, FL 32826 USA. EM jessie.chen@us.army.mil; jennifer.thropp@usa-spaceops.com NR 78 TC 39 Z9 39 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1083-4427 EI 1558-2426 J9 IEEE T SYST MAN CY A JI IEEE Trans. Syst. Man Cybern. Paart A-Syst. Hum. PD NOV PY 2007 VL 37 IS 6 BP 1063 EP 1076 DI 10.1109/TSMCA.2007.904779 PG 14 WC Computer Science, Cybernetics; Computer Science, Theory & Methods SC Computer Science GA 226LK UT WOS:000250590400018 ER PT J AU Chen, JYC Haas, EC Barnes, MJ AF Chen, Jessie Y. C. Haas, Ellen C. Barnes, Michael J. TI Human performance issues and user interface design for teleoperated robots SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART C-APPLICATIONS AND REVIEWS LA English DT Review DE human-robot interaction; multimodal displays and input controls; robotic control; teleoperation; user interface design ID VIRTUAL ENVIRONMENTS; TACTILE DISPLAY; VISUAL FEEDBACK; SYSTEMS; PERCEPTION; ORIENTATION; OPERATIONS; REALITY; TARGET; DELAY AB In the future, it will become more common for humans to team up with robotic systems to perform tasks that humans cannot realistically accomplish alone. Even for autonomous and semiautonomous systems, teleoperation will be an important default mode. However, teleoperation can be a challenging task because the operator is remotely located. As a result, the operator's situation awareness of the remote environment can be compromised and the mission effectiveness can suffer. This paper presents a detailed examination of more than 150 papers covering human performance issues and suggested mitigation solutions. The paper summarizes the performance decrements caused by video images bandwidth, time lags, frame rates, lack of proprioception, frame of reference, two-dimensional views, attention switches, and motion effects. Suggested solutions and their limitations include stereoscopic displays, synthetic overlay, multimodal interfaces, and various predicative and decision support systems. C1 USA, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Chen, JYC (reprint author), USA, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. EM jessie.chen@us.army.mil; ehaas@arl.army.mil; michael.barnes@hua.army.mil NR 151 TC 99 Z9 101 U1 5 U2 34 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6977 EI 1558-2442 J9 IEEE T SYST MAN CY C JI IEEE Trans. Syst. Man Cybern. Part C-Appl. Rev. PD NOV PY 2007 VL 37 IS 6 BP 1231 EP 1245 DI 10.1109/TSMCC.2007.905819 PG 15 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics; Computer Science, Interdisciplinary Applications SC Computer Science GA 223TN UT WOS:000250395300014 ER PT J AU Petrescu, MS Larry, CL Bowden, RA Williams, GW Gagen, D Li, Z Smith, CW Burns, AR AF Petrescu, Matei S. Larry, Chonna L. Bowden, Robert A. Williams, George W. Gagen, Debjani Li, Zhijie Smith, C. Wayne Burns, Alan R. TI Neutrophil interactions with keratocytes during corneal epithelial wound healing: A role for CD18 integrins SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article ID HUMAN POLYMORPHONUCLEAR LEUKOCYTES; MICROSCOPY IN-VIVO; COLLAGEN FIBRILS; MIGRATION; FIBROBLASTS; STROMA; LUNG; MECHANISMS; EMIGRATION; CD11/CD18 AB PURPOSE. To determine the role of keratocytes and leukocyte beta(2) ( CD18) integrins in neutrophil ( PMN) migration through the corneal stroma after epithelial scrape injury. METHODS. Using C57BL/6 wild-type and CD18(-/-) mice, corneas were excised at 6 hours ( wild-type) or 24 hours ( CD18(-/-)) after central corneal epithelial abrasion, time points determined previously to have similar levels of emigrated PMNs. Corneas were prepared for ultrastructural morphometric analysis of PMNs, keratocyte networks, and collagen. RESULTS. Transmission electron microscopy revealed intact keratocyte networks within the paralimbus that were morphometrically similar, regardless of epithelial injury or mouse genotype. Secondary to epithelial abrasion, extravasated PMNs within the paralimbus developed close contacts with keratocytes and collagen. In wild-type mice, 40% of the PMN surface was in contact with the keratocyte surface, and this value decreased to 10% in CD18(-/-) mice. PMN contact with collagen was similar in wild-type and CD18(-/-) mice, with approximately 50% of the PMN surface contacting the collagen fibrils. Since corneal edema resulting from scrape injury was similar, regardless of genotype and did not involve structural changes in collagen fibrils, these data favor a direct role for CD18 in mediating PMN contact with keratocytes. CONCLUSIONS. The data show that in response to epithelial scrape injury, PMN migration in the corneal stroma involves close contact between keratocytes and collagen. Although PMN-keratocyte contacts require CD18 integrins, contact with collagen is CD18 independent. Fundamentally, PMN migration along keratocyte networks constitutes the beginning of a new experimental concept for understanding leukocyte migration within the wounded cornea. C1 Baylor Coll Med, Dept Med, Cardiovasc Sci Sect, Houston, TX 77030 USA. Baylor Coll Med, Dept Pediat, Crit Care Sect, Houston, TX 77030 USA. US Mil Acad, West Point, NY 10996 USA. Case Sch Med, Dept Anesthesiol, Cleveland, OH USA. Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX 77030 USA. Jinan Univ, Inst Tissue Transplantat & Immunol, Guangzhou, Peoples R China. RP Burns, AR (reprint author), Baylor Coll Med, Dept Med, Cardiovasc Sci Sect, Room 515B,1 Baylor Plaza, Houston, TX 77030 USA. EM aburns@bcm.tmc.edu FU NHLBI NIH HHS [HL070357, R01 HL070537, R01 HL070537-05]; NIAID NIH HHS [R01 AI046773, R01 AI046773-05] NR 33 TC 23 Z9 24 U1 1 U2 1 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD NOV PY 2007 VL 48 IS 11 BP 5023 EP 5029 DI 10.1167/iovs.07-0562 PG 7 WC Ophthalmology SC Ophthalmology GA 228MU UT WOS:000250734800024 PM 17962453 ER PT J AU Rarick, KR Pikosky, MA Grediagin, A Smith, TJ Glickman, EL Alemany, JA Staab, JS Young, AJ Nindl, BC AF Rarick, Kevin R. Pikosky, Matthew A. Grediagin, Ann Smith, Tracey J. Glickman, Ellen L. Alemany, Joseph A. Staab, Jeffery S. Young, Andrew J. Nindl, Bradley C. TI Energy flux, more so than energy balance, protein intake, or fitness level, influences insulin-like growth factor-I system responses during 7 days of increased physical activity SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE insulin like growth factor binding proteins; exercise; nutritional factors ID RESTING METABOLIC-RATE; PLASMA SOMATOMEDIN-C; IGF-BINDING-PROTEINS; NUTRITIONAL REGULATION; FACTOR BINDING-PROTEIN-3; RESISTANCE EXERCISE; CIRCULATING LEVELS; BODY-COMPOSITION; MEN; HORMONE AB The purpose of this study was to determine the impact of dietary factors and exercise-associated factors on the response of IGF-I and its binding proteins (IGFBPs) during a period of increased physical activity. Twenty-nine men completed a 4-day (days 1-4) baseline period of a controlled energy balanced diet while maintaining their normal physical activity level followed by 7 days (days 5-11) of a 1,000 kcal/ day increase in physical activity above their normal activity levels. Two subject groups, one sedentary (Sed, mean V-O2peak: 39 ml center dot kg(-1) center dot min(-1), n = 7) and one fit (FIT1, mean V-O2peak: 56 ml center dot kg(-1) center dot min(-1), n = 8) increased energy intake to maintain energy balance throughout the 7-day intervention. In two other fit subject groups (FIT2, n = 7 and FIT3, n = 7), energy intake remained at baseline resulting in a 1,000 kcal/ day exercise-induced energy deficit. Of these, FIT2 received an adequate protein diet (0.9 g/ kg), and FIT3 received a high-protein diet (1.8 g/ kg). For all four groups, IGF-I, IGFBP-3, and the acid labile subunit (ALS) were significantly decreased by day 11 (27 +/- 4%, 10 +/- 2%, and 19 +/- 4%, respectively) and IGFBP-2 significantly increased by 49 +/- 21% following day 3. IGFBP-1 significantly increased only in the two negative energy balance groups, FIT2 (38 +/- 6%) and FIT3 (46 +/- 8%). Differences in initial fitness level and dietary protein intake did not alter the IGF-I system response to an acute increase in physical activity. Decreases in IGF-I were observed during a moderate increase in physical activity despite maintaining energy balance, suggesting that currently unexplained exercise-associated mechanisms, such as increased energy flux, regulate IGF-I independent of energy deficit. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. EM bradley.nindl@us.army.mil NR 38 TC 24 Z9 26 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD NOV PY 2007 VL 103 IS 5 BP 1613 EP 1621 DI 10.1152/japplphysiol.00179.2007 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 224WZ UT WOS:000250480400019 PM 17702838 ER PT J AU Dewey, WS Richard, RL Hedman, TL Chapman, TT Quick, CD Holcomb, JB Wolf, SE AF Dewey, William Scott Richard, Reg L. Hedman, Travis L. Chapman, Ted T. Quick, Charles D. Holcomb, John B. Wolf, Steve E. TI A review of compression glove modifications to enhance functional grip: A case series SO JOURNAL OF BURN CARE & RESEARCH LA English DT Review AB A common complaint among patients with burns is their inability to grasp items while wearing compression gloves. Recent technological innovations permit the addition of gripenhancing material to garment fabric. The purpose of this case series was to describe the course of development of compression gloves with enhanced grip modifications. Five different types of grip modifications were made during a period of 18 months. Five subjects who were prescribed compression gloves tested each type of glove. The gloves were fabricated with grip-enhancing material on the palmar surface in five ways: 1) rectangular rubber tabs; 2) honeycomb pattern silicone; 3) wave-like pattern silicone; 4) line pattern silicone beads; 5) line pattern silicone beads embedded into the fabric. Each glove was evaluated on a three-point Likert scale (0 = poor, 1 = moderate, 2 = good) for grip-enhancing qualities and durability. All five subjects reported similar experiences with each glove type: 1) the rectangular rubber tabs demonstrated poor grip and moderate durability; 2) the honeycomb pattern provided good grip but poor durability; 3) the wave pattern had good grip and moderate durability; 4) the silicone beads adhered to the fabric had moderate grip but poor durability; 5) the silicone beads embedded into the fabric had moderate grip and good durability. The wave pattern provided the best gripping capability and silicone embedded into the fabric demonstrated the best durability. A wave-like pattern silicone material embedded into the fabric seems to provide the best combination of grip and durability to enhance activities of daily living performance. C1 USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. RP Dewey, WS (reprint author), USA, Inst Surg Res, Burn Ctr, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 4 TC 2 Z9 2 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2007 VL 28 IS 6 BP 888 EP 891 DI 10.1097/BCR.0b013e318159e076 PG 4 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 230JZ UT WOS:000250874100017 PM 17992112 ER PT J AU White, CE Park, MS Renz, EM Kim, SH Ritenour, AE Wolf, SE Cancio, LC AF White, Christopher E. Park, Myung S. Renz, Evan M. Kim, Seung H. Ritenour, Amber E. Wolf, Steven E. Cancio, Leopoldo C. TI Burn center treatment of patients with severe anhydrous ammonia injury: Case reports and literature review SO JOURNAL OF BURN CARE & RESEARCH LA English DT Review ID INHALATION INJURY; RESPIRATORY-TRACT; CHEMICAL BURNS; GAS; THERAPY AB Anhydrous ammonia, a widespread industrial chemical, can cause severe inhalation and ophthalmic injuries, as well as cutaneous burns. We present five patients with ammonia injury treated at our burn center after an explosion in a warehouse. The challenges inherent in managing the pulmonary complications of this injury are emphasized. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 35 TC 7 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2007 VL 28 IS 6 BP 922 EP 928 DI 10.1097/BCR.0b013e318159a44e PG 7 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 230JZ UT WOS:000250874100024 PM 17925646 ER PT J AU Chen, RH Speyert, JL Lianos, D AF Chen, Robert H. Speyert, Jason L. Lianos, Dimitrios TI Homing missile guidance and estimation under agile target acceleration SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article; Proceedings Paper CT 9th International Qualitative Health Research Conference CY FEB, 2003 CL Guadalajara, MEXICO ID FILTER; LAW AB Two new algorithms for homing missile guidance and estimation in the two-dimensional intercept problem are proposed based on the assumption that certain targets execute evasive maneuvers orthogonal to their velocity vectors. The objectives of both algorithms are to estimate the engagement states in the presence of unknown target acceleration and guide the interceptor to hit the target based on these state estimates. Both algorithms are the integration of a filter in cascade with a guidance law, but constructed using different philosophies. One algorithm constructs the guidance law and the filter that estimates the target acceleration based on a target model in which the magnitude ofthe target acceleration vector is assumed to be a sinusoidal function. The other algorithm constructs the guidance law based on the anticipated worst possible target acceleration and constructs the filter by blocking rather than estimating the dynamic effect of the target acceleration. These two algorithms form an interesting design trade between the inherent estimation lag and increased estimation uncertainty. C1 SySense Inc, Burbank, CA 91502 USA. USA, Space & Missile Def Command, Huntsville, AL 35805 USA. RP Chen, RH (reprint author), SySense Inc, Burbank, CA 91502 USA. NR 14 TC 8 Z9 11 U1 0 U2 3 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD NOV-DEC PY 2007 VL 30 IS 6 BP 1577 EP 1589 DI 10.2514/1.30107 PG 13 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 230OJ UT WOS:000250885500002 ER PT J AU Schwab, KA Ivins, B Cramer, G Johnson, W Sluss-Tiller, M Kiley, K Lux, W Warden, D AF Schwab, Karen A. Ivins, Brian Cramer, Gayle Johnson, Wayne Sluss-Tiller, Melissa Kiley, Kevin Lux, Warren Warden, Deborah TI Screening for traumatic brain injury in troops returning from deployment in Afghanistan and Iraq: Initial investigation of the usefulness of a short screening tool for traumatic brain injury SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE traumatic brain injury (TBI); US Army; screening; validation study ID HEAD-INJURY; MILD; CONCUSSION; SPORTS AB Objective: Preliminary assessment of a new instrument, the Brief Traumatic Brain Injury Screen (BTBIS). Design: Cross-sectional study of 596 soldiers returning from Iraq and/or Afghanistan, comparing the consistency of their reports of traumatic brain injury (TBI) across instruments with similar TBI questions, and in a brief follow-up interview. Setting: Military base. Measures: Self-reported probable TBI on the BTBIS and on 2 longer questionnaires, and a brief follow-up interview. Results: Self-reports of probable TBI were higher on the BTBIS, than on the longer instruments. Participants who screened positive on the BTBIS generally provided consistent information about probable TBI in the follow-up interview. Conclusions: In this initial study, the BTBIS demonstrated promise as part of a triage process in mass casualty situations, permitting individuals with probable TBI to self-report injury and continued symptoms. Further study, including full validation and reliability assessment, is warranted and required before these screening tools can be fully evaluated. C1 Walter Reed Army Med Ctr, Defense & Vet Brain Injury Ctr, Washington, DC 20012 USA. Womack Army Med Ctr, Dept Behav Hlth, Ft Bragg, NC USA. USA, Off Surg Gen, Arlington, VA USA. RP Schwab, KA (reprint author), Walter Reed Army Med Ctr, Defense & Vet Brain Injury Ctr, Washington, DC 20012 USA. NR 26 TC 139 Z9 139 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0885-9701 J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD NOV-DEC PY 2007 VL 22 IS 6 BP 377 EP 389 DI 10.1097/01.HTR.0000300233.98242.87 PG 13 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 234RN UT WOS:000251181500008 PM 18025970 ER PT J AU Holmes, JP Mittendorf, EA Ponniah, S Peoples, GE AF Holmes, J. P. Mittendorf, E. A. Ponniah, S. Peoples, George E. TI Intra-antigenic epitope spreading in HLA-A2+breast cancer patients vaccinated with a MHC class I peptide (GP2) derived from the transmembrane region of HER2/NEU SO JOURNAL OF IMMUNOTHERAPY LA English DT Meeting Abstract CT 22nd Annual Scientific Meeting of the International-Society-for-Biological-Therapy-of-Cancer CY NOV 02-04, 2007 CL Boston, MA SP Int Soc Biol Therapy Canc C1 [Holmes, J. P.; Ponniah, S.] USUHS, Canc Vaccine Dev Program, Bethesda, MD USA. [Mittendorf, E. A.] MD Anderson Canc Ctr, Houston, TX USA. [Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1524-9557 J9 J IMMUNOTHER JI J. Immunother. PD NOV-DEC PY 2007 VL 30 IS 8 BP 896 EP 896 PG 1 WC Oncology; Immunology; Medicine, Research & Experimental SC Oncology; Immunology; Research & Experimental Medicine GA 223UB UT WOS:000250396700143 ER PT J AU Ghafoori, N Tays, MW AF Ghafoori, Nader Tays, Matthew W. TI Abrasion resistance of early-opening-to-traffic Portland cement concrete pavements SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article AB The research investigation presented herein is intended to study the abrasion resistance early-opening-to-traffic portland cement concrete pavements also known as fast-track concrete. The selected matrices are examined using two categories of opening-to-traffic times (6 and 8 h). Type III portland cement and three different cement factors with and without an accelerating admixture were used. The trial mixtures are examined for plastic properties (slump, air content, bleeding, setting times, and adiabatic temperature), bulk characteristics (demolded unit weight and compressive strength), and resistance to abrasion. Depth of wear and rate of deterioration as functions of matrix proportions, opening-time categories, and testing age (up to 20 min or 0.12 in., whichever is reached first) are determined. The influence of other parameters such as cement factor, curing age, and accelerating admixture on resistance to wear of the selected matrices are discussed. Other properties, namely rate of abrasion, relative gain of abrasion, coefficient of variation, and abrasion index, are examined. Finally, the relationship between the abrasion resistance (depth of wear) and bulk characteristic (compressive strength) at both opening and maturity ages are investigated. The findings of this investigation shall benefit highway agencies and municipalities by providing abrasion resistance data on a wide range of matrix constituents and proportions that may be used for fast-track concrete construction. C1 Univ Nevada, Dept Civil & Environm Engn, Las Vegas, NV 89154 USA. USA, Nashville, TN USA. RP Ghafoori, N (reprint author), Univ Nevada, Dept Civil & Environm Engn, 4505 Maryland Pkwy,Box 454015, Las Vegas, NV 89154 USA. EM nader.ghafoori@unlv.edu; matthew.w.tays@irn02.usace.army.mil NR 13 TC 2 Z9 2 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD NOV PY 2007 VL 19 IS 11 BP 925 EP 935 DI 10.1061/(ASCE)0899-1561(2007)19:11(925) PG 11 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 223IO UT WOS:000250363700001 ER PT J AU Koenraadt, CJM Jones, JW Sithiprasasna, R Scott, TW AF Koenraadt, C. J. M. Jones, J. W. Sithiprasasna, R. Scott, T. W. TI Standardizing container classification for immature Aedes aegypti surveillance in Kamphaeng Phet, Thailand SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes aegypti; container dynamics; vector control; Thailand; dengue ID LIFE TABLE MODEL; CULICIDAE PRODUCTION; PUPAL SURVEY; DIPTERA; DENGUE; IQUITOS; FEVER; PERU; PRODUCTIVITY; COMPETITION AB For the development of community-based vector control programs for dengue prevention, one of the key components is to formulate an adequate classification scheme for the different containers in which immature Aedes mosquitoes develop. Such a standardized scheme would permit more efficient targeting of efforts and resources in the most productive way possible. Based on field data from Kamphaeng Phet, Thailand, we developed a classification method that consists of the shape (S), use (U), and material (M) of the container (SUM-method). We determined that by targeting the four container classes that held the most Ae. aegypti pupae, adult mosquito production could theoretically be reduced by 70%. The classification method may be equally suitable for similar studies elsewhere in the world. Main advantages of the classification scheme are that categorization of containers does Dot need to be done a priori, that there is no "miscellaneous" class, and that different immature control strategies can be easily and prospectively tested with a local database. We expect that the classification strategy will 1) facilitate comparison of results among different ecological and geographic settings and 2) simplify communication among vector control personnel and affected communities. C1 Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. Armed Forces Res Inst Med Sci, US Med Component, Dept Entomol, Bangkok, Thailand. RP Koenraadt, CJM (reprint author), Univ Calif Davis, Dept Entomol, 1 Shields Ave, Davis, CA 95616 USA. EM cjk48@cornell.edu FU NIAID NIH HHS [AI034533] NR 34 TC 15 Z9 17 U1 0 U2 3 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2007 VL 44 IS 6 BP 938 EP 944 DI 10.1603/0022-2585(2007)44[938:SCCFIA]2.0.CO;2 PG 7 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 232QM UT WOS:000251034200005 PM 18047191 ER PT J AU Nguyen, TL Panchal, RG Topol, IA Lane, D Kenny, T Burnett, JC Hermone, AR McGrath, C Burt, SK Gussio, R Bavari, S AF Nguyen, Tam Luong Panchal, Rekha G. Topol, Igor A. Lane, Douglas Kenny, Tara Burnett, James C. Hermone, Ann R. McGrath, Connor Burt, Stanley K. Gussio, Rick Bavari, Sina TI A theoretical study of anthrax lethal factor inhibition by a set of novel carbamimidolyl-aryl-vinyl-carboxamidines: A possible mechanism involving zinc-ligation by amidine SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article DE three-dimensional search query; density functional theory; docking study; molecular dynamics; zinc coordination ID CRYSTAL-STRUCTURE; FACTOR PROTEASE; GUANIDINE; AMINOGLYCOSIDES; DERIVATIVES; REACTIVITY; HYDRATION; COMPLEX; LIGAND AB A congeneric set of carbamimidolyl-aryl-vinyl-carboxamidines from the National Cancer Institute (NCI) open chemical repository were identified as potent inhibitors of anthrax lethal factor (LF), a zinc-dependent metalloprotease that plays a critical role in potentiating Bacillus anthracis infection. Surprisingly, these compounds exhibited no differential change in activity with concentration. Docking studies revealed that the indole-attached amidine substituents of these inhibitors were positioned in close proximity to the biological zinc atom and could potentially function as transition-state mimetics. This broaches the stunning possibility that the dose independence of these inhibitors is linked to zinc-ligation. Because the amidine functionality is highly basic and cationic, it is generally not considered a viable zinc-binding motif. However, quantum chemical calculations on small-molecule models predicted a marked decrease in the pK(a) of the amidine functionality when it is in close proximity to zinc, thus allowing for the formation of a robust zinc-amidine bond. Published by Elsevier B.V. C1 USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. NCI, SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Frederick, MD 21702 USA. NCI, SAIC Frederick Inc, Adv Biomed Comp Ctr, Frederick, MD 21702 USA. NCI, Target Struct Based Drug Discovery Grp, Informat Technol Branch, Dev Therapeut Program, Frederick, MD 21702 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM sina.bavari@amedd.army.mil NR 28 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD NOV 1 PY 2007 VL 821 IS 1-3 BP 139 EP 144 DI 10.1016/j.theochem.2007.07.009 PG 6 WC Chemistry, Physical SC Chemistry GA 227JF UT WOS:000250652300018 ER PT J AU Nguyen, CT Kratovil, T Edwards, MJ AF Nguyen, Charles T. Kratovil, Tonya Edwards, Mary J. TI Retroperitoneal teratoma presenting as an abscess in childhood SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE retroperitoneum; teratoma; abscess AB Retroperitoneal teratomas are rare, representing only 1% to 11% of primary retroperitoneal neoplasms. They typically present as an asymptomatic abdominal mass but can grow to enormous size. This case describes a patient who initially presented in childhood with an acute abdomen because of an abdominal abscess that Was treated with Surgical drainage and antibiotics. Fifteen years later, the patient had a recurrence of symptoms and the abscess was ultimately recognized to be an infected retroperitoneal teratoma. There have been reports of intraabdominal and pelvic teratomas presenting as abscesses in adults. However, to our knowledge, there has been no prior description of this phenomenon in children. In an otherwise healthy child who presents with an unexplained abscess in the sacrococcygeal area, gonads, mediastinum, or retroperitoneum, One Should entertain the diagnosis of teratoma. Published by Elsevier Inc. C1 [Edwards, Mary J.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Nguyen, Charles T.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Kratovil, Tonya] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. RP Edwards, MJ (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. EM mary.j.edward@us.army.mil NR 12 TC 1 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD NOV PY 2007 VL 42 IS 11 AR E21 DI 10.1016/j.jpedsurg.2007.07.053 PG 3 WC Pediatrics; Surgery SC Pediatrics; Surgery GA 239XN UT WOS:000251551700040 PM 18022422 ER PT J AU Turner, CH Brennan, JK Lisal, M AF Turner, C. Heath Brennan, John K. Lisal, Martin TI Replica exchange for reactive Monte Carlo simulations SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID CHEMICAL-REACTION EQUILIBRIA; VAPOR-LIQUID INTERFACES; LENNARD-JONES CLUSTERS; CARBON MICROPORES; THERMODYNAMIC PROPERTIES; MOLECULAR SIMULATION; COMPUTER-SIMULATION; POROUS MATERIALS; PHASE-CHANGES; ENSEMBLE AB A new application of the replica exchange technique is demonstrated for use in reactive Monte Carlo simulations. The technique allows the system to traverse barriers in the free energy landscape through configuration swaps of higher temperature replicas, replicas with scaled potential energy parameters, or replicas existing at modified values of the reaction driving force (free energy of reaction). Acceptance rules are derived for the swap moves among the replicas, and the application of the replica exchange method is shown to be straightforward. We demonstrate the accuracy and efficiency of this technique by simulating the conversion of a model reaction. We find large increases in efficiency when performing simulations at computationally challenging conditions, such as high densities, particularly when a preconverged configuration reservoir is incorporated. It is possible to extend this replica exchange approach to systems involving multiple simultaneous reactions and to systems with more complex multisite reacting species. C1 Univ Alabama, Dept Biol & Chem Engn, Tuscaloosa, AL 35487 USA. USA, Ballist Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. Acad Sci Czech Republic, Inst Chem Proc Fundamentals, E Hala Lab Thermodynam, CR-16502 Prague, Czech Republic. Univ JE Purkyne, Fac Sci, Dept Phys, Usti Nad Labem 40096, Czech Republic. RP Turner, CH (reprint author), Univ Alabama, Dept Biol & Chem Engn, Tuscaloosa, AL 35487 USA. RI Lisal, Martin/A-8176-2011 OI Lisal, Martin/0000-0001-8005-7143 NR 40 TC 4 Z9 4 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 1 PY 2007 VL 111 IS 43 BP 15706 EP 15715 DI 10.1021/jp072655t PG 10 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 226AP UT WOS:000250559900027 ER PT J AU Petrov, D Videen, G Shkuratov, Y Kaydash, M AF Petrov, Dmitry Videen, Gorden Shkuratov, Yuriy Kaydash, Maryna TI Analytic T-matrix solution of light scattering from capsule and bi-sphere particles: Applications to spore detection SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article ID AGGLOMERATE PARTICLES; DEFORMED DROPLETS; BACKSCATTER; INCLUSIONS; ENSEMBLES; PLASMONS; AEROSOLS; DIMERS; SIZE AB The derivation of the Sh-matrices using the T-matrix method allows the shape-dependent parameters to be separated from size- and refractive-index-dependent parameters. This separation also allows for the surface integrals to be solved and for analytic solutions to the light scattering from some irregular morphologies to be found. In this manuscript we derive solutions for capsule-shaped and bi-sphere particles. We analyze the two-dimensional patterns resulting from these two different simulants of Bacillus subtilis spores. The large differences between the patterns suggest that simple approximations to complicated particles may not be adequate. Published by Elsevier Ltd. C1 AMSRD ARL CI EM, Army Res Lab, Adelphi, MD 20783 USA. Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Petrov, D (reprint author), AMSRD ARL CI EM, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM petrov@astron.kharkov.ua; gvideen@arl.army.mil NR 22 TC 18 Z9 18 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD NOV PY 2007 VL 108 IS 1 BP 81 EP 105 DI 10.1016/j.jqsrt.2007.04.010 PG 25 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 223DW UT WOS:000250350800006 ER PT J AU Farley, JH Harlan, LC Clegg, LX Larsen, WI Trimble, EL AF Farley, John H. Harlan, Linda C. Clegg, Limin X. Larsen, Wilma I. Trimble, Edward L. TI Patterns of care for cervical cancer patients treated in the US military health care system SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE cervix cancer; chemotherapy; National Institutes of Health; radiotherapy ID CONCURRENT CHEMOTHERAPY; RADIATION-THERAPY; CARCINOMA; SURVIVAL; CHEMORADIOTHERAPY; CHEMORADIATION; CISPLATIN AB OBJECTIVE: To determine whether women diagnosed with cervical cancer within the U.S. Department of Defense (DOD) Military Health Care System received treatment within standard guidelines and whether survival was influenced by Implementation of these guidelines. STUDY DESIGN: We identified 621 women treated from 1994 to 2002. Guideline therapy was defined as hysterectomy or radiation for FIGO stage <= IB, and hysterectomy or chemoradiation for advanced localized FIGO stage > IB. Survival analysis was performed using Cox Proportional Hazards models. RESULTS: Of those 621 women, 25% received no surgery, while 41 % received radiation therapy. 6 % of all patients received chemoradiation therapy prior to the Clinical Announcement received versus 26% of patients after the announcement. Variables associated with significant increased risk of death were advanced age, advanced stage and poorly differentiated lesions, p < 0.01. The lack of guideline therapy was associated with an increased risk of death, p < 0.005. Those patients who did not receive guideline therapy were twice as likely to die (HR 2.11, p = 0.005). CONCLUSION: Our study suggests that chemoradiation was rapidly introduced in the DOD care system after the 1999 National Cancer Institute's Clinical Announcement. However, some patients did not receive guideline therapy. C1 Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Clin Invest, Div Gynecol Oncol, Honolulu, HI 96859 USA. NCI, Clin Invest Branch, Canc Therapy Evaluat Program, Div Canc Treatment & Diag, Bethesda, MD 20892 USA. RP Farley, JH (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM john.farley@amedd.army.mil NR 15 TC 0 Z9 0 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD NOV PY 2007 VL 52 IS 11 BP 1040 EP 1045 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 235HE UT WOS:000251223500011 PM 18161403 ER PT J AU Schaden, W Thiele, R Kolpl, C Pusch, M Nissan, A Attinger, CE Maniscalco-Theberge, ME Peoples, GE Elster, EA Stojadinovic, A AF Schaden, Wolfgang Thiele, Richard Kolpl, Christine Pusch, Michael Nissan, Aviram Attinger, Christopher E. Maniscalco-Theberge, Mary E. Peoples, George E. Elster, Eric A. Stojadinovic, Alexander TI Shock wave therapy for acute and chronic soft tissue wounds: A feasibility study SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE extracorporeal shock wave therapy; soft; tissue wounds ID DOUBLE-BLIND; CLINICAL-TRIAL; CALCIFIC TENDINITIS; HYPERBARIC-OXYGEN; NEGATIVE-PRESSURE; PLANTAR FASCIITIS; LOWER-EXTREMITY; SINGLE-BLIND; SHOULDER; MANAGEMENT AB Background. Nonhealing wounds are a major, functionally-limiting medical problem impairing quality of life for millions of people each year. Various studies report complete wound epithelialization. of 48 to 56% over 30 to 65 d with different treatment modalities including ultrasound, topical rPDGF-BB, and composite acellular matrix. This is in contrast to comparison control patients treated with standard wound care, demonstrating complete epithelialization rates of 25 to 39%. Extracorporeal shock wave therapy (ESWT) may accelerate and improve wound repair. This study assesses the feasibility and safety of ESWT for acute and chronic soft-tissue wounds. Study design. Two hundred and eight patients with complicated, nonhealing, acute and chronic soft-tissue wounds were prospectively enrolled onto this trial between August 2004 and June 2006. Treatment consisted of debridement, outpatient ESWT [100 to 1000 shocks/cm(2) at 0.1 mj/mm(2), according to wound size, every I to 2 wk over mean three treatments], and moist dressings. Results. Thirty-two (15.4%) patients dropped out of the study following first ESWT and were analyzed on an intent-to-treat basis as incomplete healing. Of 208 patients enrolled, 156 (75%) had 100% wound epithelialization. During mean follow-up period of 44 d, there was no treatment-related toxicity, infection, or deterioration of any ESWT-treated wound. Intent-to-treat multivariate analysis identified age (P = 0.01), wound size <= 10 cm(2) (P = 0.01; OR = 0.36; 95% CI, 0.16 to 0.80), and duration <= 1 mo (P < 0.001; OR = 0.25; 95% CI, 0.11 to 0.55) as independent predictors of complete healing. Conclusions. The ESWT strategy is feasible and well tolerated by patients with acute and chronic soft tissue wounds. Shock wave therapy is being evaluated in a Phase III trial for acute traumatic wounds. (c) 2007 Elsevier Inc. All rights reserved. C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. AUVA Trauma Ctr Meidling, Vienna, Austria. Zentrum Extracorporale Stosswellentherapie, Berlin, Germany. Hadassah Hebrew Univ Hosp, Jerusalem, Israel. Georgetown Univ Hosp, Washington, DC 20007 USA. Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Natl Naval Med Ctr, Bethesda, MD USA. Naval Med Res Ctr, Silver Spring, MD USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Room 5C27A,6900 Georgia Ave NW, Washington, DC 20307 USA. EM alexander.stojadinovic@na.amedd.army.mil NR 34 TC 77 Z9 82 U1 1 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD NOV PY 2007 VL 143 IS 1 BP 1 EP 12 DI 10.1016/j.jss.2007.01.009 PG 12 WC Surgery SC Surgery GA 224MF UT WOS:000250450400001 PM 17904157 ER PT J AU Stevens, EL Twenhafel, NA MacLarty, AM Kreiselmeier, N AF Stevens, Edward L. Twenhafel, Nancy A. MacLarty, Anne M. Kreiselmeier, Norman TI Corynebacterial necrohemorrhagic cystitis in two female macaques SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID RENALE PYELONEPHRITIS; MODEL AB We describe severe necrohemorrhagic cystitis in a female rhesus macaque and a female cynomolgus macaque due to colonization of the urinary bladder by Corynebacterium sp. Clinically, both macaques presented with perineal bleeding and depression and, despite extensive and prolonged treatment, succumbed to the disease. At necropsy, the contents of the urinary bladders in both cases were hemorrhagic to greenish black, and the bladder mucosa was necrotic. The major microscopic finding in each case was transmural necrohemorrhagic cystitis, with vasculitis, fibrin thrombi, and myriad gram-positive coryneform bacilli. Corynebacterium renale, Streptococcus acidominimus, and S. oralis were cultured from the urinary bladder of the rhesus macaque, and a nondiphtheritic Corynebacterium was cultured from the urinary bladder of the cynomolgus macaque. Neither animal had any other noteworthy pathologic lesions unrelated to bacterial cystitis. Corynebacterial necrohemorrhagic cystitis therefore was determined to be the cause of death in both animals. To our knowledge, this is the first report of corynebacterial cystitis in nonhuman primates. C1 [Stevens, Edward L.; Twenhafel, Nancy A.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [MacLarty, Anne M.; Kreiselmeier, Norman] USA, Vet Med Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Twenhafel, NA (reprint author), USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. EM nancy.twenhafel@us.army.mil NR 10 TC 6 Z9 6 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD NOV PY 2007 VL 46 IS 6 BP 65 EP 69 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 258IX UT WOS:000252862700011 PM 17994677 ER PT J AU Roberts, MD Iosia, M Kerksick, CM Taylor, LW Campbell, B Wilborn, CD Harvey, T Cooke, M Rasmussen, C Greenwood, M Wilson, R Jitomir, J Willoughby, D Kreider, RB AF Roberts, Michael D. Iosia, Mike Kerksick, Chad M. Taylor, Lem W. Campbell, Bill Wilborn, Colin D. Harvey, Travis Cooke, Matthew Rasmussen, Chris Greenwood, Mike Wilson, Ronald Jitomir, Jean Willoughby, Darryn Kreider, Richard B. TI Effects of arachidonic acid supplementation on training adaptations in resistance-trained males SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Article AB Background: To determine the impact of AA supplementation during resistance training on body composition, training adaptations, and markers of muscle hypertrophy in resistance-trained males. Methods: In a randomized and double blind manner, 31 resistance-trained male subjects (22.1 +/- 5.0 years, 180 +/- 0.1 cm, 86.1 +/- 13.0 kg, 18.1 +/- 6.4% body fat) ingested either a placebo (PLA: 1 g.day(-1) corn oil, n = 16) or AA (AA: 1 g.day(-1) AA, n = 15) while participating in a standardized 4 day.week(-1) resistance training regimen. Fasting blood samples, body composition, bench press one-repetition maximum (1RM), leg press 1RM and Wingate anaerobic capacity sprint tests were completed after 0, 25, and 50 days of supplementation. Percutaneous muscle biopsies were taken from the vastus lateralis on days 0 and 50. Results: Wingate relative peak power was significantly greater after 50 days of supplementation while the inflammatory cytokine IL-6 was significantly lower after 25 days of supplementation in the AA group. PGE(2) levels tended to be greater in the AA group. However, no statistically significant differences were observed between groups in body composition, strength, anabolic and catabolic hormones, or markers of muscle hypertrophy (i.e. total protein content or MHC type I, IIa, and IIx protein content) and other intramuscular markers (i.e. FP and EP3 receptor density or MHC type I, IIa, and IIx mRNA expression). Conclusion: AA supplementation during resistance-training may enhance anaerobic capacity and lessen the inflammatory response to training. However, AA supplementation did not promote statistically greater gains in strength, muscle mass, or influence markers of muscle hypertrophy. C1 [Cooke, Matthew; Rasmussen, Chris; Greenwood, Mike; Wilson, Ronald; Jitomir, Jean; Willoughby, Darryn; Kreider, Richard B.] Baylor Univ, Dept Hlth Human Performance & Recreat, Waco, TX 76798 USA. [Roberts, Michael D.; Kerksick, Chad M.] Univ Oklahoma, Dept Hlth & Exercise Sci, Norman, OK 73019 USA. [Iosia, Mike] Lee Univ, Dept Hlth Exercise Sci & Secondary Educ, Cleveland, TN USA. [Taylor, Lem W.] Univ W Florida, Dept Hlth Leisure & Exercise Sci, Pensacola, FL 32514 USA. [Campbell, Bill] Univ S Florida, Sch Phys Educ & Exercise Sci, Tampa, FL USA. [Wilborn, Colin D.] Univ Mary Hardin Baylor, Dept Exercise & Sport Sci, Belton, TX USA. [Harvey, Travis] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. RP Kreider, RB (reprint author), Baylor Univ, Dept Hlth Human Performance & Recreat, Waco, TX 76798 USA. EM Mike_Roberts@ou.edu; miosia@leeuniversity.edu; Chad_Kerksick@ou.edu; ltayloriv@uwf.edu; Campbell@coedu.usf.edu; cwilborn@umhb.edu; Travis.Harvey@usma.edu; Matt_Cooke@baylor.edu; Chris_Rasmussen@baylor.edu; Mike_Greenwood@baylor.edu; rbwilsonbu@hot.rr.com; jean_jitomir@baylor.edu; darryn_willoughby@baylor.edu; Richard_Kreider@baylor.edu RI Kerksick, Chad/G-9059-2013; Kreider, Richard/O-1804-2014 OI Kerksick, Chad/0000-0003-0458-7294; Kreider, Richard/0000-0002-3906-1658 FU Molecular Nutrition (Jupiter, FL) FX Molecular Nutrition (Jupiter, FL) provided funding for this project through an unrestricted research grant to Baylor University. All researchers involved independently collected, analyzed, and interpreted the results from this study and have no financial interests concerning the outcome of this investigation. NR 56 TC 14 Z9 14 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD NOV PY 2007 VL 4 AR 21 DI 10.1186/1550-2783-4-21 PG 13 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA V17ZF UT WOS:000207974400006 PM 18045476 ER PT J AU Kheirabadi, BS Delgado, AV Dubick, MA Scherer, MR Fedyk, CG Holcomb, JB Pusateri, AE AF Kheirabadi, Bijan S. Delgado, Angel V. Dubick, Michael A. Scherer, Michael R. Fedyk, Chriselda G. Holcomb, John B. Pusateri, Anthony E. TI In vitro effect of activated recombinant factor VII (rFVIIa) on coagulation properties of human blood at hypothermic temperatures SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE hypothermia; recombinant factor VIIa; coagulation; thrombelastography (TEG); human blood ID V LIVER INJURIES; DOSE FACTOR VIIA; COAGULOPATHIC PIGS; TRAUMA PATIENTS; MASSIVE TRANSFUSION; HEMORRHAGE CONTROL; PLATELET-FUNCTION; PATIENT; HEMOPHILIA; THERAPY AB Background: Recombinant activated factor VII (rFVIIa) is currently administered off-label to control diffuse coagulopathic bleeding of patients with traumatic injuries. These patients are often cold, acidotic, and coagulopathic upon arrival and each responds differently to rFVIIa therapy. This study investigated the effects of hypothermia on clotting and the potential benefit of rFVIIa administration on blood coagulation at different hypothermic temperatures. Method: Citrated blood samples were collected from eight healthy volunteers (20-45 years old) and incubated at 37 degrees C, 34 degrees C, 31 degrees C, and 28 degrees C for 30 minutes. rFVIIa (1.26 mu g/mL equivalent to 90 mu g/kg in vivo dose) or vehicle solution (saline) was added to each blood sample, incubated (10 minutes), and analyzed at the respective temperatures by standard coagulation tests and thrombelastography. Results: The clot reaction time of blood samples, measured as prothrombin time, activated partial thromboplastin time, and R time (thrombelastography analysis), was significantly prolonged at 31 degrees C or below compared with at 37 degrees C. The clot formation rate (a angle, maximum clotting velocity [Vmax]) was decreased at all cold temperatures. Maximum clot strength (maximum amplitude) was only affected (reduced) at 28 degrees C. Addition of rFVIIa shortened the prothrombin time, activated partial thromboplastin time, and R times at every temperature, surpassing the normal (37 degrees C) temperature values in 31 degrees C and 34 degrees C cold samples. Similarly, clot formation rate parameters (clotting time, a angle, Vmax) were also improved by rFVIIa addition and normothermic values were restored in 31 degrees C and 34 degrees C cold blood samples. rFVIIa did not affect maximum amplitude at any temperature. Conclusions. Mild to moderate hypothermia delayed the initial clot reaction and reduced clot formation rate without affecting ultimate clot strength. FVHa effectively compensated for the adverse effects of hypothermia except in severe cases. These results suggest that administration of FVHa should be beneficial in enhancing hemostasis in hypothermic trauma patients Without the need for prior correction of the patient's body temperature. C1 USA, Inst Surg Res, Div Damage Control Resuscitation, Ft Sam Houston, TX USA. RP Kheirabadi, BS (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Ave, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@cen.amedd.army.mil NR 58 TC 15 Z9 15 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2007 VL 63 IS 5 BP 1079 EP 1086 DI 10.1097/TA.0b013e31815885f1 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 232BX UT WOS:000250994200021 PM 17993954 ER PT J AU Riddle, MS Halvorson, HA Shiau, D Althoff, J Monteville, MR Shaheen, H Horvath, EP Armstrong, AW AF Riddle, Mark S. Halvorson, Heather A. Shiau, Danny Althoff, Juliann Monteville, Marshall R. Shaheen, Hind Horvath, Edward P. Armstrong, Adam W. TI Acute gastrointestinal infection, respiratory illness, and noncombat injury among US military personnel during operation bright star 2005, in Northern Egypt SO JOURNAL OF TRAVEL MEDICINE LA English DT Article ID ENTEROTOXIGENIC ESCHERICHIA-COLI; UNITED-STATES SOLDIERS; NONBATTLE INJURY; COLONIZATION FACTORS; IMMUNOSORBENT-ASSAY; CARE STATISTICS; DISEASE; EXPERIENCE; DIARRHEA; ANIMALS AB Background. In the fall 2005, approximately 7,500 US military personnel participated in an exercise in the Egyptian desert. The epidemiology of disease and noncombat injury among deployed troops is important in the context of assessing current mitigation strategies and the development of future ones. Methods. To assess the prevalence and impact of diarrhea and enteropathogen distribution, we conducted a case series study. To assess the relative impact of diarrhea compared to respiratory infection and injury, we conducted a post-deployment survey and compared these data to clinic-based syndromic surveillance data. Results. We enrolled 43 patients with acute diarrhea, 21 (49%) having one or more pathogens isolated. Enterotoxigenic Escherichia coli (n = 16), enteroaggregative E coli (n = 3), and Shigella spp. (n = 3) were the most common pathogens identified. Respiratory illness had the highest incidence (73 episodes/100 person-months) compared to diarrhea (35 episodes/100 person-months) and noncombat injury (17 episodes/100 person-months), though noncombat injury more frequently resulted in lost duty days and health-care utilization. Conclusions. Noncombat injuries and illnesses have had a significant impact on military missions and continue to result in force health protection challenges today. Future studies are needed to test and evaluate countermeasures to mitigate these illnesses and injuries to increase the health of the individuals and optimize mission readiness. C1 USN, Med Res Ctr, Silver Spring, MD 20910 USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. USN, Enter Dis Program, Med Res Unit 3, Cairo, Egypt. USA, Combat Support Hosp 256th, Brooklyn, NY USA. RP Riddle, MS (reprint author), USN, Med Res Ctr, Silver Spring, MD 20910 USA. EM markriddlemd@hotmail.com RI Riddle, Mark/A-8029-2011; Valle, Ruben/A-7512-2013 NR 32 TC 11 Z9 12 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD NOV-DEC PY 2007 VL 14 IS 6 BP 392 EP 401 DI 10.1111/j.1708-8305.2007.00159.x PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 229IU UT WOS:000250797300006 PM 17995535 ER PT J AU Brassell, SA AF Brassell, Stephen A. TI Current age and race adjusted prostate specific antigen threshold values delay diagnosis of high grade prostate cancer - Editorial comment SO JOURNAL OF UROLOGY LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC 20307 USA. RP Brassell, SA (reprint author), Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC 20307 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 2007 VL 178 IS 5 BP 1932 EP 1932 DI 10.1016/j.juro.2007.07.151 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 220WC UT WOS:000250187000024 ER PT J AU Ervin, MH Chang, D Nichols, B Wickenden, A Barry, J Melngailis, J AF Ervin, Matthew H. Chang, Daniel Nichols, Barbara Wickenden, Alma Barry, John Melngailis, John TI Annealing of electron beam induced deposits of platinum from Pt(PF3)(4) SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 51st International Conference on Electron, Ion, and Photon Beam Technology and Nanofabrication CY MAY 29-JUN 01, 2007 CL Denver, CO ID GOLD; GROWTH; FILMS AB Electron beam induced deposition (EBID) is of interest as a damage-free and resist-less means of incorporating nonconventional materials such as polymer fibers, nanowires, and carbon nanotubes into integrated circuits. A novel inorganic platinum precursor-Pt(PF3)(4)-is investigated in this work, as it has previously been demonstrated to deposit Pt with resistivities close to bulk Pt when deposited using high dose rates. In this work, the effects of 100 and 200 degrees C anneals on these Pt deposits are examined. Annealing these deposits is observed to shrink the deposits and decrease their P content. As a result, the measured Pt resistivities decreased with annealing by factors of 1.6-9.9. (c) 2007 American Vacuum Society. C1 [Ervin, Matthew H.; Chang, Daniel; Nichols, Barbara; Wickenden, Alma] USA, Res Lab, Adelphi, MD 20783 USA. [Barry, John; Melngailis, John] Univ Maryland, Inst Res Electron & Appl Phys, College Pk, MD 20742 USA. RP Ervin, MH (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mervin@arl.army.mil NR 10 TC 16 Z9 16 U1 0 U2 3 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2007 VL 25 IS 6 BP 2250 EP 2254 DI 10.1116/1.2806978 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 240UA UT WOS:000251611900097 ER PT J AU Baron, PA Estill, CF Beard, JK Hein, MJ Larsen, L AF Baron, P. A. Estill, C. F. Beard, J. K. Hein, M. J. Larsen, L. TI Bacterial endospore inactivation caused by outgassing of vapourous hydrogen peroxide from polymethyl methacrylate (Plexiglas((R))) SO LETTERS IN APPLIED MICROBIOLOGY LA English DT Article DE Bacillus anthracis; decontamination; hydrogen peroxide; outgassing; Plexiglas; spore; sterilization; VHP ID BACILLUS-ANTHRACIS; SPORES AB Aims: To investigate the cause and to eliminate the inactivation of Bacillus anthracis strain Sterne spores settled onto agar and stainless steel surfaces in plastic holders. Methods and Results: In an experimental chamber in which spores settled onto sampling surfaces, vapourous hydrogen peroxide (VHP) was used for decontamination between experiments. It was demonstrated that hydrogen peroxide (H2O2) absorbed into plastic (Plexiglas (R)) surfaces and could outgas in the sample holders. Further experiments demonstrated that H2O2 was released from Plexiglas (R) sample holders in sufficient quantity to inactivate spores. High temperature degassing (30-35 degrees C) for several days or aluminum coating of the surfaces were two remedies found to be effective in preventing inadvertent spore inactivation. Conclusions: H2O2 can be absorbed into plastic and released after an extended period of time (weeks), allowing a sufficient concentration to accumulate in small volumes to inactivate spores. Outgassing the plastic or coating the surface with an impermeable layer are potential solutions to reduce spore inactivation. Significance and Impact of the Study: Many studies with bacilli and other organisms are carried out using small plastic containers that may have been sterilized using H2O2 or other agents. This study presents a cautionary note to ensure elimination of H2O2 or other sterilizing agents to prevent spurious results. C1 NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA. USA, Dugway Proving Ground, Dugway, UT USA. RP Baron, PA (reprint author), NIOSH, MSR3, 4676 Columbia Parkway, Cincinnati, OH 45226 USA. EM pbaron@cdc.gov NR 10 TC 8 Z9 8 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0266-8254 J9 LETT APPL MICROBIOL JI Lett. Appl. Microbiol. PD NOV PY 2007 VL 45 IS 5 BP 485 EP 490 DI 10.1111/j.1472-765X.2007.02209.x PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 223IE UT WOS:000250362700005 PM 17958554 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI War on two fronts: An infantry commander's war in Iraq and the Pentagon SO LIBRARY JOURNAL LA English DT Book Review C1 USA Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 1 PY 2007 VL 132 IS 18 BP 86 EP 86 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 230YV UT WOS:000250913600189 ER PT J AU Stojadinovic, A Hooke, JA Shriver, CD Nissan, A Kovatich, AJ Kao, TC Ponniah, S Peoples, GE Moroni, M AF Stojadinovic, Alexander Hooke, Jeffrey A. Shriver, Craig D. Nissan, Aviram Kovatich, Albert J. Kao, Tzu-Cheg Ponniah, Sathibalan Peoples, George E. Moroni, Maria TI HYOU1/Orp150 expression in breast cancer SO MEDICAL SCIENCE MONITOR LA English DT Article DE breast cancer; heat shock protein; HYOU1/Orp 150; prognostic factor ID OXYGEN-REGULATED PROTEIN; HEAT-SHOCK PROTEINS; PROGNOSTIC-FACTORS; CELL; HEAT-SHOCK-PROTEIN-70; ORP150; CARCINOMA; HYPOXIA; STRESS; MECHANISMS AB Background: Heat shock protein HYOU1, alternatively known as Orp150, plays an important role in hypoxia/ischemia and angiogenesis. Preliminary studies demonstrated increased HYOU1/Orp150 expression in prostate, bladder and invasive breast cancer. This study further evaluates HYOU1/Orp150 expression in different. stages of breast cancer such as benign, pre-malignant and malignant. lesions, and correlates it with clinical and pathological data. Material/Methods: Sixty-six paraffin-embedded breast tissue sections were stained by immunohistochemistry rising HYOU1/Orp150 antibody. Antibody staining was reviewed and scored 0 (lowest) to 3+ (highest). Clinico-pathological data was compared with HYOU1/Orp150 staining using ANOVA or Student's t-Test as appropriate with significance determined by P < 0.05. Results: There was a small but significant increase (P < 0.01) in HYOU1/Orp150 expression as the tumor transformed from benign (mean 1.52 +/- 0.12) to ductal carcinoma in situ (mean 2.05 +/- 0.14) and invasive carcinoma (mean 2.1 +/- 0.17). HYOU1/Orp150 was partially lost in the benign tissue adjacent to purely invasive cancer (0.88 +/- 0.22) and it was less (P=0.046) than what was found in benign only lesions (1.52 +/- 0.12) or in benign components adjacent to DCIS (1.47 +/- 0.16). Overexpression of HYOU1/Orp150 was associated with tumor lymph node involvement, presence of lymphovascular invasion, and absence of estrogen receptor expression (P < 0.01). A trend was observed between HYOU1/Orp150 and nuclear p53 overexpression (P < 0.04), but no correlation was detected with age, TNM stage, PR status, HER2/neu or Ki67. Conclusions: HYOU1/Orp150 is overexpressed in some invasive breast cancers and its overexpression appears to be associated with indicators of poor prognosis. Its association with factors such as lymphovascular invasion and regional nodal involvement suggests a possible role for HYOU1/Orp150 in metastasis. C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. Hadassah Univ Hosp, Dept Surg, IL-91120 Jerusalem, Israel. MDR Global Syst LLC, Windber, PA USA. Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Div Epidemiol & Biostat, Bethesda, MD 20814 USA. Uniformed Serv Univ Hlth Sci, Canc Vaccine Dev Lab, Bethesda, MD 20814 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Suite 5C27B,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM alexander.stojadinovic@na.amedd.army.mil NR 38 TC 20 Z9 20 U1 0 U2 1 PU INT SCIENTIFIC LITERATURE, INC PI ALBERTSON PA 1125 WILLIS AVE, ALBERTSON, NY 11507 USA SN 1234-1010 J9 MED SCI MONITOR JI Med. Sci. Monitor PD NOV PY 2007 VL 13 IS 11 BP BR231 EP BR239 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 237HP UT WOS:000251365100001 PM 17968289 ER PT J AU Eliasson, AH Lettieri, CJ AF Eliasson, Arn H. Lettieri, Christopher J. TI Sequential compression devices for treatment of restless legs syndrome SO MEDICINE LA English DT Article ID INTRAVENOUS IRON DEXTRAN; LIMB MOVEMENT-DISORDER; DOUBLE-BLIND; PLACEBO; TRIAL; PERGOLIDE; PRAMIPEXOLE; VALIDATION; ROPINIROLE; MANAGEMENT AB Restless legs syndrome (RLS) is a common disorder that presents with irresistible urges to move the legs and motor restlessness, worsening in the evening. RLS commonly causes insomnia and associated daytime symptoms. Treatment of first choice for RLS is usually medication, but medications are often ineffective or poorly tolerated. An effective nonpharmacologic therapy would be highly desirable. Here we review RLS and its treatment and present data from a pilot study-on the effect of a novel treatment for this condition. The objective of this study was to determine the therapeutic effect of pneumatic sequential compression devices (SCDs) on RLS symptoms. We performed an uncontrolled, prospective interventional study using SCDs on a convenience sample of adults reliably diagnosed with RLS. Patients were asked to wear the SCD for an hour each evening before the usual time of onset of restless legs symptoms. Before and after 1-3 months of SCD therapy, patients completed validated questionnaires to assess RLS severity, daytime sleepiness, and impact of RLS on quality of life in the domains of social function, daily task function, sleep quality, and emotional well-being. Compliance with SCD therapy was measured using patient-recorded logs. Of 10 patients (7 women; age range, 37-80 yr; mean age, 56 yr), symptomatic for a mean,of 68 months (range, 12-360 mo), I could not tolerate wearing the SCD and withdrew from the protocol after 3 days. The remaining 9 patients complied with therapy 58%-100% of nights (mean; 82%). Three patients experienced complete resolution of RLS and 6 patients had improvement of symptoms. Group severity score improved from 24/40 to 8/40 (p = 0.001). Epworth Sleepiness Scale score improved from 12/24 to 8/24 (p = 0.05). Every quality of life score improved: social function from 74% to 96% (p = 0.04), daily task function 63% to 80% (p = 0.05), sleep quality 27% to 63% (p = 0.003), and emotional wellbeing from 49% to 83% (p = 0.02). In this group of patients, wearing the SCD in the evening for an hour improved symptoms of RLS and improved quality of life, with complete resolution of symptoms in 3 of 10 patients. C1 Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA. RP Eliasson, AH (reprint author), Walter Reed Army Med Ctr, Dept Med, Pulm & Crit Care Med Serv, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM am.eliasson@us.ar-my.mil NR 34 TC 15 Z9 15 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0025-7974 J9 MEDICINE JI Medicine (Baltimore) PD NOV PY 2007 VL 86 IS 6 BP 317 EP 323 DI 10.1097/MD.0b013e31815b1319 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 234ZC UT WOS:000251202300001 PM 18004176 ER PT J AU Ely, MR Cheuvront, SN Montain, SJ AF Ely, Matthew R. Cheuvront, Samuel N. Montain, Scott J. TI Neither cloud cover nor low solar loads are associated with fast marathon performance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE environment; endurance exercise; sex; wet-bulb globe temperature; ambient temperature ID HEAT-STROKE; THERMOREGULATION; TEMPERATURE; EXERCISE; RUNNERS AB There exists a popular notion that cloud cover and/or low solar radiation increase the likelihood of running a fast marathon. This information can be found in anecdotal reports, authoritative reference books for runners, and scientific publications alike, but it lacks a comprehensive review. Purpose: 1) To determine whether the presence of cloud cover or low solar load are associated with fast marathons, 2) to describe the weather conditions during fast marathons, and 3) to determine whether the fastest men's and women's marathons are run in similar conditions. Methods: Finishing times and weather conditions were obtained for the winning performances of seven North American marathons, the 10 all-time fastest marathon times, world record marathons (WR), and Olympic Marathons for men (M) and women (F). Results: Cloud cover was not associated with a fast marathon race when odds ratios were calculated using the entire data set (0.68 (M); 0.51 (F)) or restricted to the 5-15 degrees C ambient temperature (T-db) range associated with fast race performances (0.42 (M); 0.43 (F)). Low solar load conditions also were not associated using the complete data set (1.4 (M); 1.3 (F)) or when restricted to the 5-15 degrees C range (2.25 (M); 1.1 (F)). The common factor among fast performances has been low T-db (10.6-12.8 degrees C (M); 11.6-13.6 degrees C (F)). In addition, neither cloud cover nor solar load were associated with top 10 or WR performances, because performances occurred in all cloud cover and solar load conditions. Conclusion: The presence of cloud cover or low solar load does not increase the likelihood of running a fast marathon. The prevailing temperatures during the fastest marathons (similar to 12 degrees C) corroborate previous assertions and seem similar for men and women. C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Ely, MR (reprint author), USA, Environm Med Res Inst, Kansas St, Bldg 42, Natick, MA 01760 USA. EM matthew.ely@us.anny.mil OI Ely, Matthew/0000-0002-0618-7078 NR 19 TC 19 Z9 19 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2007 VL 39 IS 11 BP 2029 EP 2035 DI 10.1249/mss.0b013e318149f2c3 PG 7 WC Sport Sciences SC Sport Sciences GA 230VB UT WOS:000250903100019 PM 17986912 ER PT J AU Martin, M Sekine, T Kobayashi, T Kecskes, L Thadhani, NN AF Martin, M. Sekine, T. Kobayashi, T. Kecskes, L. Thadhani, N. N. TI High-pressure equation of the state of a zirconium-based bulk metallic glass SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT 4th Symposium on the Dynamic Behavior of Materials held at the 2007 TMS Annual Meeting and Exhibition CY FEB 25-MAR 01, 2007 CL Orlando, FL SP TMS Struct Mat Div, TMS/ASM Mech Behav Mat Comm ID SHOCK-WAVE RESPONSE; DEFORMATION-BEHAVIOR; DYNAMIC COMPRESSION; COMPOSITES; STRENGTH; FAILURE; ALLOY; NANOCRYSTALLIZATION; SPALL AB The high stress U(s)-U(p) Hugoniot equation of state (EOS) of a zirconium-based bulk metallic glass (BMG, Zr(57)Nb(5)Cu(15.4)Ni(12.6)Al(10)) was determined using plate impact experiments on diskshaped samples of 10-mm diameter and 2-mm thickness. The National Institute for Materials Science (NIMS) two-stage light-gas gun was used for the high stress measurements (similar to 26 to 123 GPa), and the Georgia Institute of Technology (GT) single-stage gas gun was used for the lower stress measurements (similar to 5 to 26 GPa). The NIMS experiments were instrumented with streak photography and used the inclined mirror (IM) method to simultaneously measure shock velocity and free surface velocity. The GT experiments used polyvinylidene fluoride (PVDF) stress gages and velocity interferometry (VISAR) to simultaneously measure the shock velocity, free surface velocity, and stress. Results from the streak camera records and PVDF gages + VISAR traces, as well as impedance matching calculations, were used to generate the U(s)-U(p) Hugoniot EOS for the BMG over a wide range of stresses. The U(s)-U(p) data show evidence of a low pressure phase, a transition to a mixed phase region at similar to 26 GPa, followed by transition at similar to 67 GPa to a high-pressure phase of bulk modulus of 288 GPa. C1 Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. Natl Inst Mat Sci, Adv Mat Lab, Tsukuba, Ibaraki 3050044, Japan. USA, Res Lab, Weapons & Mat Res Directorate, AMSRD ARL WM MB, Aberdeen Proving Ground, MD 21005 USA. RP Martin, M (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. EM naresh.thadhani@mse.gatech.edu RI Trexler, Morgana/E-9003-2013; Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 39 TC 20 Z9 21 U1 1 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD NOV PY 2007 VL 38A IS 11 BP 2689 EP 2696 DI 10.1007/s11661-007-9263-x PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 231JX UT WOS:000250944100009 ER PT J AU Cancio, LC Stout, LR Jezior, JR Melton, LP Walker, JA Brengman, ML Neumeier, ST Smith, RL Vanfosson, CA Knuth, TE Holcomb, JB AF Cancio, Leopoldo C. Stout, Louis R. Jezior, James R. Melton, Lisette P. Walker, Joy A. Brengman, Matthew L. Neumeier, Sonia T. Smith, Robin L. Vanfosson, Christopher A. Knuth, Thomas E. Holcomb, John B. TI Wartime burn care in Iraq: 28th combat support hospital, 2003 SO MILITARY MEDICINE LA English DT Article ID OPERATION ENDURING FREEDOM; EXPERIENCE; MILITARY; STRESS; ARMY; TRAUMA; NURSES; RESUSCITATION; AFGHANISTAN; ANESTHESIA AB The U.S. Army 28th Combat Support Hospital (CSH), an echelon III facility, deployed to Iraq at the start of military operations in 2003. Shortly after arrival, it was designated as the hospital primarily responsible for burn care for the U.S. military in Iraq. This report reviews the experience of the CSH with burn care during combat operations. Methods: An after-action review was conducted during a 2-day period after the hospital's redeployment. Results: Between April 11, 2003, and August 21, 2003, the 28th CSH treated a total of 7,920 patients, of whom 103 (1.3%) had burns. Patients included U.S. and allied service members, U.S. contractors, and Iraqi prisoners of war and civilians. Although a CSH is designed to care for patients until they can be stabilized and evacuated, usually within I to 3 days, the length of stay for some Iraqi patients was as long as 53 days. Definitive care, including excision and grafting of the burn wound, was thus required for some Iraqi patients. The largest graft completed comprised 40% of the total body surface area. The largest burn survived involved similar to 65% of the total body surface area. Eighteen (17%) of 103 patients returned to duty after treatment at the 28th CSH. The mortality rate for burn patients at the 28th CSH was 8%. Shortages of burn-experienced personnel and burn-specific supplies were identified during the after-action review. Conclusions: The CSH provided complex definitive care to burn patients in an austere environment. Predeployment identification of military field hospitals for such specialized missions, with early assignment of experienced personnel and materiel to these units, may improve future wartime burn care. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. 28th Combat Support Hosp, Med Command Corps Airborne 44, Ft Bragg, NC 28310 USA. USA, Med Dept & Sch, Directorate Combat Doctrine Dev, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 54 TC 6 Z9 7 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1148 EP 1153 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300004 PM 18062387 ER PT J AU Rastogi, VK Wallace, L Smith, LS AF Rastogi, Vipin K. Wallace, Lalena Smith, Lisa S. TI Disinfection of Acinetobacter baumannii-contaminated surfaces relevant to medical treatment facilities with ultraviolet c light SO MILITARY MEDICINE LA English DT Article ID NOSOCOMIAL INFECTIONS; RESISTANCE; INACTIVATION; SPORES AB The efficacy of ultraviolet C (UVC) light (100-280 nm) in the decontamination of three hospital-related surfaces, namely, unpainted/painted aluminum (bed railings), stainless steel (operating tables), and scrubs (laboratory coats), was investigated. Acinetobacter baumannii cells were inoculated (101 or 101 cells) on small coupons and dried overnight in a class II biosafety cabinet. Drying resulted in <= 50% loss of viability. The UVC fluence of 90 J/m(2) was observed to be very effective in the decontamination of cells from all metal coupon surfaces (complete killing). However, the same fluence was ineffective in the decontamination of scrubs. The effectiveness of two other common disinfection practices, that is, 15 minutes of boiling or spraying with 70% ethanol, was investigated for the scrubs. Although ethanol treatment was ineffective, the boiling treatment was very effective (complete killing). These results establish that metal surfaces can be decontaminated with UVC irradiation and boiling treatment is effective for scrub decontamination. C1 USA, Edgewood Chem & Biol Ctr, Biodef Team, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Rastogi, VK (reprint author), USA, Edgewood Chem & Biol Ctr, Biodef Team, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. NR 13 TC 18 Z9 20 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1166 EP 1169 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300007 PM 18062390 ER PT J AU Sheehan, JJ Mott, PJ Sisk, BW Arbogast, JW Ferrazzano-Yaussy, C Bondi, CAM AF Sheehan, James J. Mott, Peter J. Sisk, Brian W. Arbogast, James W. Ferrazzano-Yaussy, Cristina Bondi, Cara A. M. TI Alcohol-based instant hand sanitizer use in military settings: A prospective cohort study of army basic trainees SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Annual Conference of the American-College-of-Preventive-Medicine CY FEB 23, 2007 CL Miami, FL SP Amer Coll Prevent Med ID ILLNESS; ABSENTEEISM; HYGIENE; PROGRAM AB We investigated the impact of a customized alcohol-based instant hand sanitizer hand-hygiene regimen in an Army basic training setting. The entire population at the U.S. Army Field Artillery Training Center, Fort Sill, Oklahoma, participated in the 13-week prospective cohort study between January 18, 2005 and April 18, 2005. Two training battalions were randomly assigned to the control group, one to the primary intervention group (customized Purell Instant Hand Sanitizer regimen, education, reinforcement) and one to the secondary intervention group (customized Purell Instant Hand Sanitizer regimen). When compared to the control group, intervention groups experienced 40% less respiratory illness (p < 0.001), 48% less gastrointestinal illness (p < 0.02), 44% less lost training time (p < 0.001), and 31% fewer health care encounters (p < 0.001). These findings suggest that this intervention is capable of significantly reducing illness in this setting and has the potential to help reduce absenteeism in the military workforce as a whole. C1 Acad Hlth Sci, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. USA, Ctr Hlth Promot & Prevent Med, Directorate Hlth Promot & Wellness, Aberdeen Proving Ground, MD 21010 USA. GOJO Ind Inc, Res & Dev, Akron, OH 44311 USA. Univ Hosp Cleveland, Clin Res Ctr, Cleveland, OH 44106 USA. RP Sheehan, JJ (reprint author), Acad Hlth Sci, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. NR 22 TC 18 Z9 19 U1 3 U2 12 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2007 VL 172 IS 11 BP 1170 EP 1176 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 232FS UT WOS:000251004300008 ER EF