FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Cardo, L Wilder, D Doane, S Reddy, H Fitzpatrick, C Goodrich, R AF Cardo, L. Wilder, D. Doane, S. Reddy, H. Fitzpatrick, C. Goodrich, R. TI Characterization of packed red blood cells after pathogen inactivation of whole blood using riboflavin and UV light SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Doane, S.; Reddy, H.; Fitzpatrick, C.; Goodrich, R.] LLC, Navigant Biotechnol, Lakewood, CO USA. [Cardo, L.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM ray.goodrich@navigantbiotech.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 87A EP 87A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118400253 ER PT J AU Cardo, L Wilder, D Doane, S Reddy, H Fitzpatrick, C Goodrich, R AF Cardo, L. Wilder, D. Doane, S. Reddy, H. Fitzpatrick, C. Goodrich, R. TI Neutrophil priming by stored PRBC is not increased by pathogen inactivation of whole blood using riboflavin and UV light SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Cardo, L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Reddy, H.; Goodrich, R.] LLC, Navigant Biotechnol, Lakewood, CO USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 88A EP 89A PG 2 WC Hematology SC Hematology GA 347CO UT WOS:000259118400259 ER PT J AU Cardo, L Salata, J AF Cardo, L. Salata, J. TI Mechanism of removal of Plasmaodium falciparum infected erythrocytes from blood products by leukoreduction filters SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Cardo, L.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM salatajm@mail.nih.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 88A EP 88A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118400258 ER PT J AU Cardo, L Salata, J AF Cardo, L. Salata, J. TI Removal of Plasmaodium falciparum infected erythrocytes from whole blood by leukoreduction filters SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Cardo, L.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM salatajm@mail.nih.gov NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 89A EP 89A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118400261 ER PT J AU McFaul, S Corley, J Mester, C Nath, J AF McFaul, Steve Corley, J. Mester, C. Nath, J. TI Cytokine accumulation in stored packed red stood cells SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [McFaul, Steve; Nath, J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Mester, C.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM jayasree.nath@us.army-mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 159A EP 159A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118400465 ER PT J AU Macdonald, VW Wilder, D Salata, JM Hess, J AF Macdonald, V. W. Wilder, D. Salata, J. M. Hess, J. TI Impact of high and low volume collections on red blood cell quality during storage for eight weeks SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Univ Maryland, Sch Med, Baltimore, MD 21201 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 161A EP 161A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118400469 ER PT J AU Cardo, L Wilder, D AF Cardo, L. Wilder, D. TI Surface expression of phosphatidylserine (PS) leads to adherence of erythrocytes to leukoreduction filter fibers SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Cardo, L.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM donna.wilder@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 163A EP 164A PG 2 WC Hematology SC Hematology GA 347CO UT WOS:000259118401004 ER PT J AU McFaul, S Matheu, F AF McFaul, Steve Matheu, F. TI Supernates from AS-5 stored packed red blood cells inhibit platelet aggregation SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [McFaul, Steve] Walter Reed Army Inst Res, Silver Spring, MD USA. [Matheu, F.] Reg Blood Donor Ctr Great Lakes, Highland Pk, IL USA. EM frederick.matheu@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 163A EP 163A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118401003 ER PT J AU Hmel, P Macdonald, V AF Hmel, P. Macdonald, V. TI Two-tier hemoglobin stabilization to prevent oxidation during lyophilization provides an alternative to liquid storage SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Hmel, P.; Macdonald, V.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM victor.macdonald@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 165A EP 165A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118401007 ER PT J AU Selvapandiyan, A Duncan, R Mendez, J Kumar, R Salotra, P Cardo, LJ Nakhasi, HL AF Selvapandiyan, Angamuthu Duncan, Robert Mendez, Juan Kumar, Rajesh Salotra, Poonam Cardo, Lisa J. Nakhasi, Hira L. TI A Leishmania minicircle DNA footprint assay for sensitive detection and rapid speciation of clinical isolates SO TRANSFUSION LA English DT Article ID REAL-TIME PCR; POLYMERASE-CHAIN-REACTION; AZAR DERMAL LEISHMANIASIS; KINETOPLAST DNA; CUTANEOUS-LEISHMANIASIS; VISCERAL LEISHMANIASIS; KALA-AZAR; BLOOD-DONORS; MUCOSAL LEISHMANIASIS; INFANTUM PARASITEMIA AB BACKGROUND: Diversity in clinical outcome, due to different species of Leishmania, and its presence in asymptomatic blood donors in endemic areas warrant development of methods that are sensitive and can rapidly identify infecting species. STUDY DESIGN AND METHODS: The kinetoplast minicircle DNA is known to have heterogeneity in sequence and is present in many thousands of copies in Leishmania. Fluorescence-based polymerase chain reaction (PCR) was used to amplify minicircle DNA from six Leishmania species from different geographic locations. The sequences were then used to construct a phylogenetic tree. Speciation of 46 blinded parasite clinical isolates from various geographic regions was validated using the assay. RESULTS: Analysis displayed a distinct cluster for each species or strain. Forty-three of 46 isolates were correctly assigned to the same species identified by isoenzyme electrophoresis. The three untyped isolates were all either new species or samples from a unique geographic region. The minicircles of the three isolates formed new clusters in the tree analysis. Using minicircle DNA as PCR target, the sensitivity of the parasite detection in the spiked blood samples was five parasites per mL. CONCLUSION: Increased sensitivity and speciation without the need for parasite culture will be useful for diagnosis and treatment in clinical settings. C1 US FDA, Div Emerging & Transfus Transmitted Dis, Off Blood Res & Review, Ctr Biol Evaluat & Res, Bethesda, MD USA. Walter Reed Army Inst Res, Dept Blood Res, Transfus Med Branch, Silver Spring, MD USA. Safdarjang Hosp, Inst Pathol, Indian Council Med Res, New Delhi, India. RP Selvapandiyan, A (reprint author), Bldg 29,Room 425,8800 Rockville Pike, Bethesda, MD 20892 USA. EM angamuthu.selvapandiyan@fda.hhs.gov RI Duncan, Robert/I-8168-2015 OI Duncan, Robert/0000-0001-8409-2501 FU CBER/OBRR; US Army Combat Casualty Care Research; Medical Research and Materiel Command FX Support for this study was provided by the CBER/OBRR intramural funds and by the US Army Combat Casualty Care Research Program, Medical Research and Materiel Command. NR 63 TC 15 Z9 15 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 9 BP 1787 EP 1798 DI 10.1111/j.1537-2995.2008.01798.x PG 12 WC Hematology SC Hematology GA 347CN UT WOS:000259118300005 PM 18564397 ER PT J AU Fritz, EA Geisbert, JB Geisbert, TW Hensley, LE Reed, DS AF Fritz, Elizabeth A. Geisbert, Joan B. Geisbert, Thomas W. Hensley, Lisa E. Reed, Douglas S. TI Cellular Immune Response to Marburg Virus Infection in Cynomolgus Macaques SO VIRAL IMMUNOLOGY LA English DT Article ID EBOLA HEMORRHAGIC-FEVER; NECROSIS-FACTOR-ALPHA; CD4(+)CD8(+) T-CELLS; NEUTRALIZING ANTIBODIES; NONHUMAN-PRIMATES; DENDRITIC CELLS; MONKEYS; BLOOD; LYMPHOCYTES; PROCOAGULANT AB Marburg virus (MARV) causes a severe and usually lethal hemorrhagic disease in humans and non-human primates. Here, 16 cynomolgus macaques were experimentally infected with the Ci67 strain of MARV. Blood and spleen samples were collected at various time points after infection to study the immunological response to MARV. Beginning at day 2 and continuing throughout the course of the infection there was a rise in antigen-presenting cells in both the blood and spleen expressing MARV glycoprotein. Natural killer (NK) cells declined in the blood after infection (from 15% on day 0 to 5% on day 6), but a small increase was seen in the spleen samples. Little or no change in CD4(+) or CD8(+) T cells was observed out to day 6 post-exposure in blood, while there was a continual decline in the percentage of CD8(+) T cells in spleen samples. Circulating B cells (defined as CD20(+)) increased during the course of the infection as did CD4(+)CD8(+) (double-positive) T cells. Intracellular cytokine staining indicated that by day 6 a large population of leukocytes in the spleen were producing IFN-alpha; analysis of surface markers indicated that these cells were plasmacytoid dendritic cells based on their expression of CD123(+), but these cells had decreased expression of class II MHC. IL-6 production was detected late in the infection in CD14(+) spleen cells. These results suggest a robust innate immune response to MARV; however, this response was delayed relative to the infection. C1 [Reed, Douglas S.] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA 15261 USA. [Fritz, Elizabeth A.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Geisbert, Joan B.; Geisbert, Thomas W.] Boston Univ, Boston, MA 02215 USA. RP Reed, DS (reprint author), Univ Pittsburgh, Ctr Vaccine Res, 8037 BST3,3501 5th Ave, Pittsburgh, PA 15261 USA. EM dsreed@cvr.pitt.edu OI Reed, Douglas/0000-0003-0076-9023 FU U. S. Army Medical Research and Materiel Command [02-4-4J-081] FX The authors acknowledge the efforts of Carlton Rice and veterinary medicine animal caretakers for the care of the animals used in this study.; The views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official Department of Army position, policy, or decision, unless so designated by other documentation.; This research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals, and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International.; The authors do not have a commercial or other association that would pose a conflict of interest.; The research described herein was sponsored by the U. S. Army Medical Research and Materiel Command Project #02-4-4J-081. NR 40 TC 29 Z9 30 U1 1 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0882-8245 J9 VIRAL IMMUNOL JI Viral Immunol. PD SEP PY 2008 VL 21 IS 3 BP 355 EP 363 DI 10.1089/vim.2008.0023 PG 9 WC Immunology; Virology SC Immunology; Virology GA 357XM UT WOS:000259880500011 PM 18788943 ER PT J AU Cohen, JB Karpanty, SM Catlin, DH Fraser, JD Fischer, RA AF Cohen, Jonathan B. Karpanty, Sarah M. Catlin, Daniel H. Fraser, James D. Fischer, Richard A. TI Winter Ecology of Piping Plovers at Oregon Inlet, North Carolina SO WATERBIRDS LA English DT Article DE activity budget; behavior; Charadrius melodus; habitat; North Carolina; radio telemetry; Piping Plover; restoration; shorebirds; winter ID UNITED-STATES; HABITAT; SELECTION; SHOREBIRDS AB Humans may modify winter habitat of the imperiled Piping Plover (Charadrius melodus), yet published accounts of the species winter ecology are rare. We studied Piping Plovers at Oregon Inlet, North Carolina from December 2005 to March 2006. Plovers used a 20.1 km(2) area (100% minimum convex polygon home range) containing narrow barrier islands with ocean sound-side beaches, and small shoals, dredged-material islands, and marsh islands in shallow-water sounds. Plover activity was concentrated in twelve areas totaling 2.2 km(2) (95% fixed kernel home range). When plovers were on ocean beaches, they spent less time foraging (18%) than when on Sound Island beaches (88%) and islands (83%, P = 0.003). Sound island use increased and beach use decreased as the tide dropped (Logistic regression, P < 0.001). Plover use of dredged-material islands implied that habitat managers can create or restore attractive foraging sites where habitat may be declining or limiting. Wintering habitat management should aim to provide foraging opportunities during most of the day across a range of tide conditions and ensure that foraging habitat is close to roost sites. C1 [Cohen, Jonathan B.; Karpanty, Sarah M.; Catlin, Daniel H.; Fraser, James D.] Virginia Tech, Dept Fisheries & Wildlife Sci, Blacksburg, VA 24061 USA. [Fischer, Richard A.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Cohen, JB (reprint author), Virginia Tech, Dept Fisheries & Wildlife Sci, Blacksburg, VA 24061 USA. EM jocohen1@vt.edu NR 44 TC 9 Z9 9 U1 2 U2 15 PU WATERBIRD SOC PI WASHINGTON PA NATL MUSEUM NATURAL HISTORY SMITHSONIAN INST, WASHINGTON, DC 20560 USA SN 1524-4695 J9 WATERBIRDS JI Waterbirds PD SEP PY 2008 VL 31 IS 3 BP 472 EP 479 PG 8 WC Ornithology SC Zoology GA 374KY UT WOS:000261043500020 ER PT J AU Talbot, CA Ogden, FL AF Talbot, Cary A. Ogden, Fred L. TI A method for computing infiltration and redistribution in a discretized moisture content domain SO WATER RESOURCES RESEARCH LA English DT Article ID RICHARDS EQUATION; SOIL-WATER; MODELING INFILTRATION; BOUNDARY-CONDITIONS; NUMERICAL-SOLUTION; AMPT INFILTRATION; CAPILLARY DRIVE; POROUS-MEDIA; FLOW; GROUNDWATER AB A new one-dimensional infiltration and redistribution method is proposed as an alternative to the Richards equation (RE) for coupled surface and subsurface models. The proposed method discretizes soil water content into hypothetical hydraulically interacting bins. The entry and propagation of displacement fronts in each bin are simulated by means of explicit infiltration and drainage approximations based on capillary and gravitational driving forces. Wetting front advances within bins create water deficits that are satisfied by capillary- driven interbin flow. The method inherently provides numerical stability by precluding the need to directly estimate nonlinear gradients through numerical schemes. Comparisons of the performance of this method against RE solutions for theoretical, laboratory, and field data in both well- drained and high water table conditions are presented. The new method produces infiltration flux estimates with errors less than 10% compared to a widely used RE solution in tests on multiple soil textures with and without high water table conditions while providing unconditionally guaranteed conservation of mass. C1 [Talbot, Cary A.] USA, Ctr Res Dev & Engn, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn, Dept 3295, Laramie, WY 82071 USA. RP Talbot, CA (reprint author), USA, Ctr Res Dev & Engn, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM cary.a.talbot@erdc.usace.army.mil FU US Army Engineer Research and Development Center; U.S. Army Research Office through DEPSCoR [W911NF-07-1-0389] FX The authors gratefully acknowledge the assistance of Dani Or and Stacy Howington for their insight and comments in the development of this method and paper. They also wish to thank Walter Rawls for graciously providing a copy of his out-of-print report containing valuable infiltration data and Jirka Simunek for providing guidance on the appropriate usage of Hydrus- 1D for the tests described in this paper and useful comments on the manuscript. They also wish to thank Tammo Steenhuis and two anonymous reviewers for their constructive comments. Tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the sponsorship of the US Army Corps of Engineers System-Wide Water Resources Program by the US Army Engineer Research and Development Center. Research efforts on the part of the second author were supported in part by the U. S. Army Research Office through DEPSCoR Grant W911NF-07-1-0389. Permission was granted by the Chief of Engineers to publish this information. NR 50 TC 13 Z9 13 U1 1 U2 7 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD AUG 30 PY 2008 VL 44 IS 8 AR W08453 DI 10.1029/2008WR006815 PG 14 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 343BF UT WOS:000258826600006 ER PT J AU Kopczynski, S Ramage, J Lawson, D Goetz, S Evenson, E Denner, J Larson, G AF Kopczynski, S. Ramage, J. Lawson, D. Goetz, S. Evenson, E. Denner, J. Larson, G. TI Passive microwave (SSM/I) satellite predictions of valley glacier hydrology, Matanuska Glacier, Alaska SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID DRAINAGE SYSTEM; SNOWPACK; SNOWMELT; ONSET; MELT AB We advance an approach to use satellite passive microwave observations to track valley glacier snowmelt and predict timing of spring snowmelt-induced floods at the terminus. Using 37 V GHz brightness temperatures (Tb) from the Special Sensor Microwave Imager (SSM/I), we monitor snowmelt onset when both Tb and the difference between the ascending and descending overpasses exceed fixed thresholds established for Matanuska Glacier. Melt is confirmed by ground-measured air temperature and snow-wetness, while glacier hydrologic responses are monitored by a stream gauge, suspended-sediment sensors and terminus ice velocity measurements. Accumulation area snowmelt timing is correlated (R(2) = 0.61) to timing of the annual snowmelt flood peak and can be predicted within +/- 5 days. C1 [Goetz, S.] Earth Tech, Sheboygan, WI USA. [Denner, J.] US Geol Survey, Montpelier, VT USA. [Larson, G.] Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. [Ramage, J.; Evenson, E.] Lehigh Univ, Dept Earth & Environm Sci, Bethlehem, PA 18015 USA. [Kopczynski, S.; Lawson, D.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Kopczynski, S (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM sarah.e.kopczynski@usace.army.mil FU NASA Graduate Student Earth System Science [NNX06AG08H]; NASA Terrestrial Hydrology [NNG04GR31G]; US Army Dissertation LTT Research Fellowship; Lehigh University FX We thank the National Snow and Ice Data Center for EASE-Grid SSM/I satellite data and William Stevenson of Alaska Outfitting for glacier and high-alpine guide support. Funding was provided by the NASA Graduate Student Earth System Science grant (NNX06AG08H), NASA Terrestrial Hydrology grant (NNG04GR31G), US Army Dissertation LTT Research Fellowship, and Lehigh University. This manuscript was improved by helpful discussions with Richard Alley and two anonymous reviewers. NR 15 TC 5 Z9 5 U1 3 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD AUG 29 PY 2008 VL 35 IS 16 AR L16502 DI 10.1029/2008GL034615 PG 5 WC Geosciences, Multidisciplinary SC Geology GA 342YV UT WOS:000258820400002 ER PT J AU Lim, WT Jang, JH Kim, SH Norton, DP Craciun, V Pearton, SJ Ren, F Shen, H AF Lim, Wantae Jang, Jung Hun Kim, S. -H. Norton, D. P. Craciun, V. Pearton, S. J. Ren, F. Shen, H. TI High performance indium gallium zinc oxide thin film transistors fabricated on polyethylene terephthalate substrates SO APPLIED PHYSICS LETTERS LA English DT Article ID TEMPERATURE; SEMICONDUCTORS; TFTS; STABILITY; TIME AB High-performance amorphous (alpha-) InGaZnO-based thin film transistors (TFTs) were fabricated on flexible polyethylene terephthalate substrates coated with indium oxide (In2O3) films. The InGaZnO films were deposited by rf magnetron sputtering with the presence of O-2 at room temperature. The n-type carrier concentration of InGaZnO film was similar to 2 x 10(17) cm(-3). The bottom-gate-type TFTs with SiO2 or SiNx gate dielectric operated in enhancement mode with good electrical characteristics: saturation mobility 11.5 cm(2) V-1 s(-1) for SiO2 and 12.1 cm(2) V-1 s(-1) for SiNx gate dielectrics and drain current on-to-off ratio >10(5). TFTs with SiNx gate dielectric exhibited better performance than those with SiO2. This is attributed to the relatively high dielectric constant (i.e., high-k material) of SiNx. After more than 500 h aging time at room temperature, the saturation mobility of the TFTs with SiO2 gate dielectric was comparable to the as-fabricated value and the threshold voltage shift was 150 mV. (C) 2008 American Institute of Physics. C1 [Lim, Wantae; Jang, Jung Hun; Kim, S. -H.; Norton, D. P.; Craciun, V.; Pearton, S. J.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Ren, F.] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. [Shen, H.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Lim, WT (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.edu RI Craciun, Valentin/C-4789-2011 FU Army Research Office [DAAD19-01-1-0603]; Army Research Laboratory; NSF [DMR 0700416] FX The work at UF was supported in part by the Army Research Office under Grant No. DAAD19-01-1-0603 (monitored by Dr. M. Gerhold) and the Army Research Laboratory and NSF (Grant No. DMR 0700416, Dr. L. Hess). We thank MAIC and UFNF staff for their help in the performance of this work. NR 25 TC 72 Z9 75 U1 5 U2 18 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 25 PY 2008 VL 93 IS 8 AR 082102 DI 10.1063/1.2975959 PG 3 WC Physics, Applied SC Physics GA 345QR UT WOS:000259011900042 ER PT J AU Sahoo, S Maranganti, R Lastella, S Mallick, G Karna, S Sharma, P Ajayan, PM AF Sahoo, Sangeeta Maranganti, Ravi Lastella, Sarah Mallick, Govind Karna, Shashi Sharma, Pradeep Ajayan, Pulickel M. TI Reversible separation of single-walled carbon nanotubes in bundles SO APPLIED PHYSICS LETTERS LA English DT Article AB We show that electrostatic charging of nanotubes and the consequent repulsion can lead to reversible separation of individual single-walled carbon nanotubes in bundles. Low-energy electron beam irradiation leads to this completely reversible phenomenon. A simple semianalytical model is used to explain the observed separation mechanism. The reversibility of the separation process is attributed to discharging and thermal-fluctuation induced motion of the nanotubes in ambient air. Further, the separation impacts the electrical conductance of small nanotube bundled devices. (c) 2008 American Institute of Physics. C1 [Sahoo, Sangeeta; Lastella, Sarah] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Maranganti, Ravi; Sharma, Pradeep] Univ Houston, Dept Mech Engn, Houston, TX 77204 USA. [Mallick, Govind; Karna, Shashi] USA, Res Lab, AMSRD ARL WM BD, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. RP Sahoo, S (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. EM sahoos@rpi.edu RI Sharma, Pradeep/D-4123-2012 FU RPI; IFC New York; Army Research Laboratory; National Science Foundation NSEC FX We acknowledge financial supports from RPI, IFC New York at RPI, Army Research Laboratory, and the National Science Foundation NSEC. S. S. thanks David Frey, Subbalakshmi Sreekala, and Sudhir Husale for their invaluable suggestions. NR 15 TC 1 Z9 1 U1 1 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 25 PY 2008 VL 93 IS 8 AR 083120 DI 10.1063/1.2976631 PG 3 WC Physics, Applied SC Physics GA 345QR UT WOS:000259011900084 ER PT J AU Meirom, RA Clark, T Polcawich, R Pulskamp, J Dubey, M Muhlstein, CL AF Meirom, R. A. Clark, T. Polcawich, R. Pulskamp, J. Dubey, M. Muhlstein, C. L. TI Velocity-dependent fatigue crack paths in nanograined Pt films SO PHYSICAL REVIEW LETTERS LA English DT Article ID SLIP HOMOGENEITY; COPPER; BEHAVIOR; METALS; BANDS AB Studies of crack growth in nanograined films assert that mechanical damage accumulates at grain boundaries irrespective of the crack velocity and loading conditions. This work shows that crack advance in nanograined Pt films involves a dislocation-slip mechanism that is a function of the crack growth rate and mode of loading. Crack paths in Pt were initially intergranular, but transitioned to a transgranular mode that persisted until catastrophic failure. This research demonstrates that crack growth mechanisms modeled for nanograined Ni cannot be generalized to other pure, metallic systems. C1 [Meirom, R. A.; Clark, T.; Muhlstein, C. L.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Meirom, R. A.; Clark, T.; Muhlstein, C. L.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA. [Polcawich, R.; Pulskamp, J.; Dubey, M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Muhlstein, CL (reprint author), Penn State Univ, Dept Mat Sci & Engn, 202B Steidle Bldg, University Pk, PA 16802 USA. EM clm28@psu.edu FU U. S. Army Research Office [W911NF-05-1-00640]; Pennsylvania State University Materials Research Institute NanoFabrication Network; National Science Foundation Cooperative [0335765] FX The authors acknowledge the support of the U. S. Army Research Office (ARO No. W911NF-05-1-00640, program manager Dr. Bruce LaMattina). This work was also supported by the Pennsylvania State University Materials Research Institute NanoFabrication Network and the National Science Foundation Cooperative Agreement No. 0335765, National Nanotechnology Infrastructure Network, with Cornell University. The authors thank Dr. Don Koss for his insights into the fracture surface analyses. NR 23 TC 13 Z9 13 U1 0 U2 7 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD AUG 22 PY 2008 VL 101 IS 8 AR 085503 DI 10.1103/PhysRevLett.101.085503 PG 4 WC Physics, Multidisciplinary SC Physics GA 340KD UT WOS:000258643600043 PM 18764634 ER PT J AU Odhiambo, CO Otieno, W Adhiambo, C Odera, MM Stoute, JA AF Odhiambo, Collins O. Otieno, Walter Adhiambo, Christine Odera, Michael M. Stoute, Jose A. TI Increased deposition of C3b on red cells with low CRI and CD55 in a malaria-endemic region of western Kenya: Implications for the development of severe anemia SO BMC MEDICINE LA English DT Article ID COMPLEMENT-REGULATORY PROTEINS; TUMOR-NECROSIS-FACTOR; PLASMODIUM-FALCIPARUM; CLINICAL PRESENTATION; BINDING-CAPACITY; FLOW-CYTOMETRY; RECEPTOR CR-1; ERYTHROCYTES; TRANSMISSION; CHILDREN AB Background: Severe anemia due to Plasmodium falciparum malaria is a major cause of mortality among young children in western Kenya. The factors that lead to the age-specific incidence of this anemia are unknown. Previous studies have shown an age-related expression of red cell complement regulatory proteins, which protect erythrocytes from autologous complement attack and destruction. Our primary objective was to determine whether in a malaria-endemic area red cells with low levels of complement regulatory proteins are at increased risk for complement (C3b) deposition in vivo. Secondarily, we studied the relationship between red cell complement regulatory protein levels and hemoglobin levels. Methods: Three hundred and forty-two life-long residents of a malaria-holoendemic region of western Kenya were enrolled in a cross-sectional study and stratified by age. We measured red cell C3b, CRI, CD55, and immune complex binding capacity by flow cytometry. Individuals who were positive for malaria were treated and blood was collected when they were free of parasitemia. Analysis of variance was used to identify independent variables associated with the %C3b-positive red cells and the hemoglobin level. Results: Individuals between the ages of 6 and 36 months had the lowest red cell CRI, highest %C3b-positive red cells, and highest parasite density. Malaria prevalence also reached its peak within this age group. Among children <= 24 months of age the %C3b-positive red cells was usually higher in individuals who were treated for malaria than in uninfected individuals with similarly low red cell CRI and CD55. The variables that most strongly influenced the %C3b-positive red cells were age, malaria status, and red cell CD55 level. Although it did not reach statistical significance, red cell CRI was more important than red cell CD55 among individuals treated for malaria. The variables that most strongly influenced the hemoglobin level were age, the %C3b-positive red cells, red cell CRI, and red cell CD55. Conclusion: Increasing malaria prevalence among children > 6 to <= 36 months of age in western Kenya, together with low red cell CRI and CD55 levels, results in increased C3b deposition on red cells and low hemoglobin. The strong contribution of age to C3b deposition suggests that there are still additional unidentified age-related factors that increase the susceptibility of red cells to C3b deposition and destruction. C1 [Stoute, Jose A.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Odhiambo, Collins O.; Otieno, Walter; Adhiambo, Christine; Odera, Michael M.] USA, Med Res Unit, Nairobi, Kenya. [Odhiambo, Collins O.; Otieno, Walter; Adhiambo, Christine; Odera, Michael M.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Stoute, Jose A.] Walter Reed Army Inst Res, Dept Cellular Injury, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Stoute, Jose A.] Penn State Coll Med, Hershey, PA 17033 USA. RP Stoute, JA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. EM codhiambo@wrp-ksm.org; wotieno@wrp-ksm.org; cadhiambo@wrpksm.org; modera@wrp-ksm.org; jstoute@psu.edu FU US Army Medical Research and Materiel Command; National Heart Lung and Blood Institute [R01 HL 7502]; Fogarty International Center [1 D43 TW06239] FX We would like to thank the participants for their willingness to contribute to this research endeavor. We are indebted to our dedicated staff of clinicians, nurses, drivers and field workers who made this study possible. In particular, we thank Stacey Gondi for serving as research coordinator. Mr. Meng Shi is thanked for statistical advice. This work is published with the permission of the Office of the Director, the Kenya Medical Research Institute.; This work was supported in part by the US Army Medical Research and Materiel Command and by a grant from the National Heart Lung and Blood Institute (R01 HL 7502), Jose A. Stoute PI. Walter Otieno was supported by a training grant from the Fogarty International Center (1 D43 TW06239).; "The views of the authors do not purport to reflect the position of the Department of the Army or the Department of Defense. The U. S. Government has the right to retain a nonexclusive, royalty- free license in and to any copyright covering this paper." NR 40 TC 24 Z9 24 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1741-7015 J9 BMC MED JI BMC Med. PD AUG 21 PY 2008 VL 6 AR 23 DI 10.1186/1741-7015-6-23 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA 370DY UT WOS:000260744100001 PM 18717995 ER PT J AU Warren, RE Vanderbeek, RG Ben-David, A Ahl, JL AF Warren, Russell E. Vanderbeek, Richard G. Ben-David, Avishai Ahl, Jeffrey L. TI Simultaneous estimation of aerosol cloud concentration and spectral backscatter from multiple-wavelength lidar data SO APPLIED OPTICS LA English DT Article AB We present a sequential algorithm for estimating both concentration dependence on range and time and backscatter coefficient spectral dependence of optically thin localized atmospheric aerosols using data from rapidly tuned lidar. The range dependence of the aerosol is modeled as an expansion of the concentration in an orthonormal basis set whose coefficients carry the time dependence. Two estimators are run in parallel: a Kalman filter for the concentration range and time dependence and a maximum-likelihood estimator for the aerosol backscatter wavelength and time dependence. These two estimators exchange information continuously over the data-processing stream. The state model parameters of the Kalman filter are also estimated sequentially together with the concentration and backscatter. Lidar data collected prior to the aerosol release are used to estimate the ambient lidar return. The approach is illustrated on atmospheric backscatter long-wave infrared (CO2) lidar data. (C) 2008 Optical Society of America. C1 [Warren, Russell E.] EO Stat Inc, Chapel Hill, NC 27517 USA. [Vanderbeek, Richard G.; Ben-David, Avishai] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Ahl, Jeffrey L.] JLA Technol Corp, Washington, DC 20024 USA. RP Warren, RE (reprint author), EO Stat Inc, 10010 Vail Dr, Chapel Hill, NC 27517 USA. EM eostatinc@aol.com NR 7 TC 11 Z9 12 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD AUG 20 PY 2008 VL 47 IS 24 BP 4309 EP 4320 DI 10.1364/AO.47.004309 PG 12 WC Optics SC Optics GA 347GI UT WOS:000259128200002 PM 18716635 ER PT J AU Andzelm, J Sloan, JM Napadensky, E AF Andzelm, Jan Sloan, James M. Napadensky, Eugene TI COMP 280-Modeling linear and three-arm triblock SIBS copolymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Andzelm, Jan; Sloan, James M.; Napadensky, Eugene] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jandzelm@arl.army.mil; enapadensky@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 280-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256304255 ER PT J AU Byrd, CM Tsao, CY Sumner, JJ Bentley, WE AF Byrd, Christopher Matthew Tsao, Chen-Yu Sumner, James J. Bentley, William E. TI BIOT 178-LsrR-mediated switching of gene expression in E-coli based upon phosphorylation of the quorum-sensing signal molecule AI-2 SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Byrd, Christopher Matthew; Tsao, Chen-Yu; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Byrd, Christopher Matthew; Tsao, Chen-Yu; Bentley, William E.] Univ Maryland, Ctr Biosyst Res, UMBI, College Pk, MD 20742 USA. [Sumner, James J.] USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EO, Adelphi, MD 20783 USA. EM cbyrd@umd.edu; jtsao@umd.edu; jsumner@arl.army.mil; bentley@umd.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 178-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256302293 ER PT J AU Dai, DC Larson, RA Amberg, SM Jones, KF Allen, RD Lebsack, K Cashman, KA Guttieri, MC Bolken, TC Hruby, DE AF Dai, Dongcheng Larson, Ryan A. Amberg, Sean M. Jones, Kevin F. Allen, Robert D. Lebsack, Kira Cashman, Kathleen A. Guttieri, Mary C. Bolken, Tove C. Hruby, Dennis E. TI MEDI 328-Discovery of a potent anti-Lassa fever virus drug SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Dai, Dongcheng; Larson, Ryan A.; Amberg, Sean M.; Jones, Kevin F.; Allen, Robert D.; Lebsack, Kira; Bolken, Tove C.; Hruby, Dennis E.] SIGA Technol Inc, Corvallis, OR 97333 USA. [Cashman, Kathleen A.; Guttieri, Mary C.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM ddai@siga.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 328-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256305403 ER PT J AU Gaysin, A Chen, YF Lopez-Sanchez, M Savoy, DN Billadeau, DD Dow, GS Kozikowski, A AF Gaysin, Arsen Chen, Yufeng Lopez-Sanchez, Miriam Savoy, Dons N. Billadeau, Daniel D. Dow, Geoffrey S. Kozikowski, Alan TI MEDI 114-Potent and selective thiazolyl- and triazolylphenyl-based HDAC inhibitors with anticancer and antimalarial activities SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Gaysin, Arsen; Chen, Yufeng] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA. [Lopez-Sanchez, Miriam; Dow, Geoffrey S.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Savoy, Dons N.; Billadeau, Daniel D.] Mayo Grad & Med Sch, Dept Pharmacol, Rochester, MN 55905 USA. [Savoy, Dons N.; Billadeau, Daniel D.] Mayo Grad & Med Sch, Dept Immunol, Rochester, MN 55905 USA. [Kozikowski, Alan] Univ Illinois, Dept Med Chem & Pharmacognosy, Drug Discovery Program, Chicago, IL 60612 USA. EM agaysin@uic.edu; kozikowa@uic.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 114-MEDI PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256305617 ER PT J AU Hebert, CG Valdes, JJ Bentley, WE AF Hebert, Colin G. Valdes, James J. Bentley, William E. TI BIOT 68-Improving recombinant protein production in the Baculovirus Expression Vector System via RNA interference mediated silencing of Tn-caspase SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, Ctr Biosyst Res, UMBI, College Pk, MD 20742 USA. [Valdes, James J.] USA, Mol Engn Team, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. EM cghebert@umd.edu; bentley@umd.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 68-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256302364 ER PT J AU Hoffman, RC Pritchett, TM Orlicki, JA Rawlett, AM Herman, WN Park, DH AF Hoffman, Robert C. Pritchett, Timothy M. Orlicki, Joshua A. Rawlett, Adam M. Herman, Warren N. Park, Dong Hun TI POLY 601-High-voltage poling of a bulk slab of disperse red 1-polymethylmethacrylate guest-host polymer SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Hoffman, Robert C.; Pritchett, Timothy M.] USA, Res Lab, AMSRD ARL SE EM, Adelphi, MD 20783 USA. [Orlicki, Joshua A.; Rawlett, Adam M.] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [Park, Dong Hun] Univ Maryland, Lab Phys Sci, Dept Elect & Comp Engn, College Pk, MD 20740 USA. EM robert.c.hoffman@us.army.mil; tpritchett@arl.army.mil; jorlicki@arl.army.mil; arawlett@arl.army.mil; herman@lps.umd.edu; leomac@umd.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 601-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256308338 ER PT J AU Hood, MA Wang, BB LaScala, JJ Sands, JM Beyer, FL Orlicki, JA Hsieh, AJ VanLandingham, M Li, CY AF Hood, Matthew Allen Wang, Bingbing LaScala, John J. Sands, James M. Beyer, Frederick L. Orlicki, Joshua A. Hsieh, Alex J. VanLandingham, Mark Li, Christopher Y. TI POLY 83-Morphological control of segmented polyurethane/silica nanocomposites by tailoring crystallization of hard/soft segments SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Hood, Matthew Allen] Drexel Univ, Dept Mat Sci, Philadelphia, PA 19104 USA. [Wang, Bingbing; Li, Christopher Y.] Drexel Univ, AJ Drexel Nanotechnol Inst, Philadelphia, PA 19104 USA. [Wang, Bingbing; Li, Christopher Y.] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. [LaScala, John J.] USA, Res Lab, Maryland, MD 21005 USA. [Orlicki, Joshua A.] USA, Res Lab, Div Mat, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [VanLandingham, Mark] USA, Res Lab, AMSRL WM MA, Div Mat, Aberdeen Proving Ground, MD 21005 USA. EM mah79@drexel.edu; bw76@drexel.edu; jsands@arl.army.mil; flbeyer@arl.army.mil; jorlicki@arl.army.mil; ahsieh@arl.mil; mvanlandingham@arl.army.mil; cyl24@drexel.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 83-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256308403 ER PT J AU Isayev, O Gorb, L Cenas, N Qasim, M Leszczynski, J AF Isayev, Olexandr Gorb, Leonid Cenas, Narimantas Qasim, Mo Leszczynski, Jerzy TI COMP 330-Transformation of nitrocompounds by nitroreductase SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Isayev, Olexandr; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Cenas, Narimantas] Lithuania Acad Sci, Inst Biochem, Dept Biochem Xenobiot, LT-232600 Vilnius, Lithuania. [Qasim, Mo] USA, Erdc, Vicksburg, MS 39180 USA. EM alex@ccmsi.us; lgorb@ccmsi.us; jerzy@ccmsi.us NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 330-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256304284 ER PT J AU Liu, GJ Larson, SL Talley, JW AF Liu, Guojing Larson, Steven L. Talley, Jeffrey W. TI ENVR 49-Iron or copper doped hydroxyapatite shows improved As(V) removal from water SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Liu, Guojing; Talley, Jeffrey W.] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. [Larson, Steven L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM gliu@nd.edu; Jeffrey.W.Talley.2@nd.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 49-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256304491 ER PT J AU Muller, WS Arcidiacono, S Meehan, A Racicot, K Soares, J Stenhouse, P AF Muller, Wayne S. Arcidiacono, Steve Meehan, Alexa Racicot, Ken Soares, Jason Stenhouse, Peter TI AGFD 161-Prebiotic potential of hydrolyzed konjac glucomannan by growth comparisons with two commercial prebiotics SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Muller, Wayne S.; Arcidiacono, Steve; Meehan, Alexa; Racicot, Ken; Soares, Jason; Stenhouse, Peter] USA, Res Dev & Engn Command, Natick, MA 01760 USA. EM wayne.muller@us.army.mil NR 0 TC 0 Z9 0 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 161-AGFD PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256300210 ER PT J AU Sliozberg, YR Andzelm, J Pryamitsyn, V Ganesan, V AF Sliozberg, Yelena R. Andzelm, Jan Pryamitsyn, Victor Ganesan, Venkat TI COMP 279-Mesoscale simulation of viscoelastic behavior of ABA triblock copolymers SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Sliozberg, Yelena R.; Andzelm, Jan] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Pryamitsyn, Victor; Ganesan, Venkat] Univ Texas Austin, Dept Chem Engn, Austin, TX 78712 USA. EM yelena.r.sliozberg@arl.army.mil; jandzelm@arl.army.mil; venkat@che.utexas.edu RI Pryamitsyn, Victor/J-4540-2013 OI Pryamitsyn, Victor/0000-0003-2128-7461 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 279-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256304108 ER PT J AU Sliozberg, YR Abrams, CF AF Sliozberg, Yelena R. Abrams, Cameron F. TI BIOL 143-Simulation study of inter-ring communication of E-coli chaperonin GroEL SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Sliozberg, Yelena R.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Abrams, Cameron F.] Drexel Univ, Dept Chem Engn, Philadelphia, PA 19104 USA. EM yelena.r.sliozberg@arl.army.mil; cfa22@drexel.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 143-BIOL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256301561 ER PT J AU Snyder, JF Nguyen, PAT AF Snyder, James F. Nguyen, Phuong-Anh T. TI PMSE 181-Developing multifunctional polymer systems with structural properties and efficient ion transport SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Snyder, James F.; Nguyen, Phuong-Anh T.] USA, Mat Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jsnyder@arl.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 181-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 500EC UT WOS:000270280001322 ER PT J AU Synowczynski, J Andzelm, J Mpourmpakis, G Vlachos, DG AF Synowczynski, Jennifer Andzelm, Jan Mpourmpakis, Giannis Vlachos, Dionisios G. TI COMP 283-Theoretical investigation of the interaction of H2O, H-2, O-2, OH species with the alpha-Al2O3 (0001) surface SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Synowczynski, Jennifer; Andzelm, Jan] USA, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Mpourmpakis, Giannis] Univ Delaware, Dept Chem Engn, Ctr Catalyt Sci & Technol, Newark, DE 19716 USA. [Vlachos, Dionisios G.] Univ Delaware, Dept Chem Engn, Colburn Lab, Newark, DE 19716 USA. EM jenns@arl.army.mil; jandzelm@arl.army.mil; gmpourmp@udel.edu; vlachos@che.udel.edu RI Mpourmpakis, Giannis/H-2048-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 283-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256304202 ER PT J AU Tsao, CY Hooshangi, S Wang, L Valdes, JJ Bentley, WE AF Tsao, Chen-Yu Hooshangi, Sara Wang, Liang Valdes, James J. Bentley, William E. TI BIOT 237-Developing a true autoinducible recombinant protein expression platform by harnessing native quorum signaling circuitry in Escherichia coli SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Tsao, Chen-Yu; Hooshangi, Sara; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Tsao, Chen-Yu; Hooshangi, Sara; Wang, Liang; Bentley, William E.] Univ Maryland, Ctr Biosyst Res, UMBI, College Pk, MD 20742 USA. [Valdes, James J.] USA, Engn Res & Dev Ctr, Edgewood, MD USA. EM jtsao@umd.edu; shoosh@umd.edu; bentley@umd.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 237-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256302330 ER PT J AU Walker, J Gibson, HS Gibson, P Andzelm, JW AF Walker, John Gibson, Heidi Schreuder Gibson, Phillip Andzelm, Jan W. TI PHYS 330-The role of water in modulating reactivity within selectively permeable membranes. SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Walker, John; Gibson, Heidi Schreuder] USA, Natick Soldier Res Dev & Engn Ctr, Natick Soldier Ctr, Natick, MA 01760 USA. [Andzelm, Jan W.] USA, Res Lab, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA. EM john.e.walker1@us.army.mil; heidi.schreudergibson@us.army.mil; phillip.gibson@us.army.mil; jandzelm@arl.army.mil RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 330-PHYS PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256307363 ER PT J AU Zhu, MQ Paul, KW Kubicki, J Sparks, D AF Zhu, Mengqiang Paul, Kristian W. Kubicki, James Sparks, Donald TI GEOC 40-Quantum chemical modeling arsenic (III,V) adsorption and oxidation on manganese oxides SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 236th National Meeting of the American-Chemical-Society CY AUG 17-21, 2008 CL Philadelphia, PA SP Amer Chem Soc C1 [Zhu, Mengqiang; Sparks, Donald] Univ Delaware, Dept Plant & Soil Sci, Newark, DE 19716 USA. [Zhu, Mengqiang; Sparks, Donald] Univ Delaware, Ctr Crit Zone Res, Newark, DE 19716 USA. [Paul, Kristian W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Kubicki, James] Penn State Univ, Dept Geosci, University Pk, PA 16802 USA. EM mzhu@UDel.Edu; kristian.paul@arl.army.mil; kubicki@geosc.psu.edu; dlsparks@udel.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 17 PY 2008 VL 236 MA 40-GEOC PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 499WD UT WOS:000270256304844 ER PT J AU Jackson, JL Pickett, CA Hemann, BA Atwood, JE AF Jackson, Jeffrey L. Pickett, Christopher A. Hemann, Brian A. Atwood, J. Edwin TI Carotid bruits and cardiovascular death or myocardial infarction - Reply SO LANCET LA English DT Letter C1 [Jackson, Jeffrey L.; Pickett, Christopher A.; Hemann, Brian A.; Atwood, J. Edwin] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Hemann, Brian A.; Atwood, J. Edwin] Walter Reed Army Med Ctr, Dept Cardiol, Washington, DC 20307 USA. [Jackson, Jeffrey L.; Atwood, J. Edwin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Pickett, CA (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM christopher.pickett1@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD AUG 16 PY 2008 VL 372 IS 9638 BP 534 EP 535 DI 10.1016/S0140-6736(08)61230-1 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 339MS UT WOS:000258582300022 ER PT J AU Zapor, M Petersen, K Rajnik, M AF Zapor, Michael Petersen, Kyle Rajnik, Michael TI Let us keep the medical literature free of perjorative language and political bias SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID AFGHANISTAN; IRAQ C1 [Zapor, Michael] Walter Reed Army Med Ctr, Infect Dis Serv, Dept Med, Washington, DC 20307 USA. [Zapor, Michael; Petersen, Kyle; Rajnik, Michael] Armed Forces Infec Dis Soc, Washington, DC USA. [Petersen, Kyle] Natl Naval Med Ctr, Bethesda, MD USA. RP Zapor, M (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, Dept Med, 6900 Georgia Ave, Washington, DC 20307 USA. EM michael.zapor@na.amedd.army.mil NR 4 TC 1 Z9 1 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD AUG 15 PY 2008 VL 47 IS 4 BP 587 EP 587 DI 10.1086/590254 PG 1 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 327VD UT WOS:000257755700028 PM 18636961 ER PT J AU Poynton, HC Loguinov, AV Varshavsky, JR Chan, S Perkins, EI Vulpe, CD AF Poynton, Helen C. Loguinov, Alexandre V. Varshavsky, Julia R. Chan, Sarah Perkins, Edward I. Vulpe, Chris D. TI Gene expression profiling in Daphnia magna part I: Concentration-dependent profiles provide support for the No Observed Transcriptional Effect Level SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MOLECULAR CHARACTERIZATION; ECOTOXICOLOGY; VITELLOGENIN; BIOMARKERS; TOXICITY; COPPER AB Ecotoxicogenomic approaches to environmental monitoring provide holistic information, offer insight into modes of action, and help to assess the causal agents and potential toxicity of effluents beyond the traditional end points of death and reproduction. Recent investigations of toxicant exposure indicate dose-dependent changes are a key issue in interpreting genomic studies. Additionally, there is interest in developing methods to integrate gene expression studies in environmental monitoring and regulation, and the No Observed Transcriptional Effect Level (NOTEL) has been proposed as a means for screening effluents and unknown chemicals for toxicity. However, computational methods to determine the NOTEL have yet to be established. Therefore, we examined effects on gene expression in Daphnia magna following exposure to Cu, Cd, and Zn over a range of concentrations including a tolerated, a sublethal, and a nearly acutely toxic concentration. Each concentration produced a distinct gene expression profile. We observed differential expression of a very few genes at tolerated concentrations that were distinct from the expression profiles observed at concentrations associated with toxicity. These results suggest that gene expression analysis may offer a strategy for distinguishing toxic and nontoxic concentrations of metals in the environment and provide support for a NOTEL for metal exposure in D. magna. Mechanistic insights could be inferred from the concentration-dependent gene expression profiles including metal specific effects on disparate metabolic processes such as digestion, immune response, development and reproduction, and less specific stress responses at higher concentrations. C1 [Poynton, Helen C.; Loguinov, Alexandre V.; Varshavsky, Julia R.; Chan, Sarah; Vulpe, Chris D.] Univ Calif Berkeley, Nutr Sci & Toxicol & Berkeley Inst Environm, Berkeley, CA 94720 USA. [Perkins, Edward I.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Vulpe, CD (reprint author), Univ Calif Berkeley, Nutr Sci & Toxicol & Berkeley Inst Environm, 119 Morgan Hall, Berkeley, CA 94720 USA. EM vulpe@berkeley.edu NR 23 TC 57 Z9 59 U1 1 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 15 PY 2008 VL 42 IS 16 BP 6250 EP 6256 DI 10.1021/es8010783 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 337MG UT WOS:000258439600066 PM 18767695 ER PT J AU Poynton, HC Zuzow, R Loguinov, AV Perkins, EJ Vulpe, CD AF Poynton, Helen C. Zuzow, Rick Loguinov, Alexandre V. Perkins, Edward J. Vulpe, Chris D. TI Gene expression profiling in Daphnia magna, part II: Validation of a copper specific gene expression signature with effluent from two copper mines in California SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID MICROARRAY; TOXICITY; CHEMICALS; CANCER AB Genomic technologies show great potential for classifying disease states and toxicological impacts from exposure to chemicals into functional categories. In environmental monitoring, the ability to classify field samples and predict the pollutants present in these samples could contribute to monitoring efforts and the diagnosis of contaminated sites. Using gone expression analysis, we challenged our custom Daphnia magna cDNA microarray to determine the presence of a specific metal toxicant in blinded field samples collected from two copper mines in California. We compared the gene expression profiles from our field samples to previously established expression profiles for Cu, Cd, and Zn. The expression profiles from the Cu-containing field samples clustered with the laboratory-exposed Cu-specific gene expression profiles and included genes previously identified as copper biomarkers, verifying that gene expression analysis can predict environmental exposure to a specific pollutant. In addition, our study revealed that upstream field samples containing undetectable levels of Cu caused the differential expression of only a few genes, lending support for the concept of a no observed transcriptional effect level (NOTEL). If confirmed by further studies, the NOTEL may play an important role in discriminating polluted and nonpolluted sites in future monitoring efforts. C1 [Poynton, Helen C.; Zuzow, Rick; Loguinov, Alexandre V.; Vulpe, Chris D.] Univ Calif Berkeley, Berkeley, CA 94720 USA. [Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Vulpe, CD (reprint author), Univ Calif Berkeley, 119 Morgan Hall, Berkeley, CA 94720 USA. EM vulpe@berkeley.edu NR 19 TC 26 Z9 26 U1 0 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG 15 PY 2008 VL 42 IS 16 BP 6257 EP 6263 DI 10.1021/es800262k PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 337MG UT WOS:000258439600067 PM 18767696 ER PT J AU Bondokov, RT Mueller, SG Morgan, KE Slack, GA Schujman, S Wood, MC Smart, JA Schowalter, LJ AF Bondokov, Robert T. Mueller, Stephan G. Morgan, Kenneth E. Slack, Glen A. Schujman, Sandra Wood, Mark C. Smart, Joseph A. Schowalter, Leo J. TI Large-area AlN substrates for electronic applications: An industrial perspective SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 5th International Workshop on Bulk Nitride Semiconductor CY SEP 24-28, 2007 CL Itaparica, BRAZIL DE substrates; growth from vapor; organometallic vapor phase epitaxy; nitrides; semiconducting III-V materials; light emitting diodes ID ALUMINUM NITRIDE CRYSTALS; SUBLIMATION GROWTH; BULK ALN; SINGLE-CRYSTALS; GAN; AIN AB We report on the status of the vapor growth of high-quality AlN bulk crystals by the sublimation-recondensation technique for the commercial production of AlN wafers up to 2 in diameter. AlN boules and wafers have been characterized by X-ray Laue backscattering, diffraction, and rocking curves measured in double-axis configuration, demonstrating a full-width at half-maximum (FWHM) of 28 and 32 arcsec for the symmetric and asymmetric rocking curves, respectively. The etch pit density (EPD) for different AlN substrate orientations was found to be less than 104 cm(-2). Impurity levels have been measured by glow discharge mass-spectrometry (GDMS) and secondary ion mass-spectroscopy (SIMS). The oxygen content as measured by SIMS shows concentrations < 10 cm. Additionally, a high thermal conductivity of similar to 270 W/mK has been measured by the flash method. High-quality homoepitaxial and graded AlGaN layers were grown on the on-axis-oriented AlN substrates. The lack of both piezoelectric and spontaneous polarization fields, for nitride heterostructures grown in non-polar directions, has recently created significant interest in high-quality, non-polar nitride Substrates to boost the performance of light emitting diodes (LEDs) and laser diodes. Initial epitaxial results on non-polar AlN substrates are presented. (c) 2008 Elsevier B.V. All rights reserved. C1 [Bondokov, Robert T.; Mueller, Stephan G.; Morgan, Kenneth E.; Slack, Glen A.; Schujman, Sandra; Smart, Joseph A.; Schowalter, Leo J.] Crystal IS Inc, Green Island, NY 12183 USA. [Wood, Mark C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Mueller, SG (reprint author), Crystal IS Inc, 70 Cohoes Ave, Green Island, NY 12183 USA. EM Mueller@Crystal-IS.com OI Muller, Stephan/0000-0002-1383-5715 NR 23 TC 47 Z9 49 U1 4 U2 34 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD AUG 15 PY 2008 VL 310 IS 17 BP 4020 EP 4026 DI 10.1016/j.jcrysgro.2008.06.032 PG 7 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 356DS UT WOS:000259759500025 ER PT J AU Tauber, E Kollaritsch, H von Sonnenburg, F Lademann, M Jilma, B Firbas, C Jelinek, T Beckett, C Knobloch, J McBride, WJH Schuller, E Kaltenbock, A Sun, W Lyons, A AF Tauber, E. Kollaritsch, H. von Sonnenburg, F. Lademann, M. Jilma, B. Firbas, C. Jelinek, T. Beckett, C. Knobloch, J. McBride, W. J. H. Schuller, E. Kaltenboeck, A. Sun, W. Lyons, A. TI Randomized, double-blind, placebo-controlled phase 3 trial of the safety and tolerability of IC51, an inactivated Japanese encephalitis vaccine SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID VIRUS-VACCINE; SA14-14-2 AB Background. Japanese encephalitis (JE) is the most important mosquito-borne viral encephalitis and has a high case fatality rate. It is caused by Japanese encephalitis virus. Improved vaccines are urgently needed for residents in countries of endemicity, travelers, and the military. The aim of the present trial was to evaluate the safety and tolerability of IC51, Intercell's Vero cell-derived, purified, inactivated JE vaccine. Methods. This was a randomized (3:1), double-blind, placebo-controlled, multicenter phase 3 trial. Healthy subjects were randomized to receive 2 doses of IC51 (n = 2012) or placebo (n = 663) at a 4-week interval. Adverse events following immunization (AEFI) were documented over a period of 2 months. Results. The rate of severe AEFI was similar in the IC51 group (0.5%) and the placebo group (0.9%). The rate of medically attended AEFI and all AEFI was also similar in the IC51 group and the placebo group. The same applied for all adverse events, including local and systemic tolerability. Importantly, there were no signs of acute allergic reactions. Conclusion. The Intercell JE vaccine IC51 had a safety profile similar to that of placebo. These data, together with the immunogenicity data from a recent phase 3 trial, form the basis of application for licensure of this vaccine. Trial registration. ClinicalTrials.gov identifier: NCT00605058. C1 [Kaltenboeck, A.] Med Univ Vienna, Intercell AG, Vienna, Austria. [Kollaritsch, H.] Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Ctr Physiol & Pathophysiol, Vienna, Austria. [Jilma, B.; Firbas, C.] Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria. [von Sonnenburg, F.] Univ Munich, Dept Trop Med & Infect Dis, Munich, Germany. [Lademann, M.] Univ Rostock, Dept Trop Med, Rostock, Germany. [Jelinek, T.] Berlin Ctr Travel & Trop Med, Berlin, Germany. [Knobloch, J.] Univ Tubingen, Inst Trop Med, Tubingen, Germany. [Beckett, C.] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA. [Sun, W.; Lyons, A.] Walter Reed Army Inst Res, Div Virus Dis, Silver Spring, MD USA. [McBride, W. J. H.] James Cook Univ, Cairns Base Hosp, Sch Med, Cairns, Australia. RP Jilma, B (reprint author), Med Univ Austria, Dept Clin Pharmacol, Waehringerguertel 18-20, A-1090 Vienna, Austria. EM Bernd.Jilma@meduniwien.ac.at RI Lyons, Arthur/B-8923-2011; McBride, William/B-9145-2008; OI McBride, William/0000-0001-8894-533X; Kollaritsch, Herwig/0000-0001-6393-516X; Tauber, Erich/0000-0001-8042-2403 NR 30 TC 49 Z9 50 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 15 PY 2008 VL 198 IS 4 BP 493 EP 499 DI 10.1086/590116 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 329TK UT WOS:000257893300007 PM 18588481 ER PT J AU Hohn, KL DuBois, T AF Hohn, Keith L. DuBois, Terry TI Simulation of a fuel reforming system based on catalytic partial oxidation SO JOURNAL OF POWER SOURCES LA English DT Article DE catalytic partial oxidation; hydrogen; fuel reforming; JP-8 ID MILLISECOND CONTACT TIMES; DIESEL FUEL; HIGHER HYDROCARBONS; CELL SYSTEMS; HYDROGEN; CHALLENGES; CONVERSION; PROCESSOR; KINETICS; GAS AB Catalytic partial oxidation (CPO) has potential for producing hydrogen that can be fed to a fuel cell for portable power generation. In order to be used for this purpose, catalytic partial oxidation must be combined with other processes, Such as water-gas shift and preferential oxidation, to produce hydrogen with minimal carbon monoxide. This paper evaluates the use of catalytic partial oxidation in an integrated system for conversion of a military logistic fuel, JP-8. to high-purity hydrogen. A fuel processing system using CPO as the first processing step is simulated to understand the trade-offs involved in using CPO. The effects of water flow rare, CPO reactor tempetature, carbon to oxygen ratio in the CPO reactor, temperature of preferential oxidation, oxygen to carbon ratio in the preferential oxidation reactor, and temperature for the water-gas shift reaction are evaluated. The possibility of recycling water from the fuel cell for use in fuel processing is evaluated. Finally, heat integration options are explored. A process efficiency, defined as the ratio of the lower heating value of hydrogen to that of JP-8, of around 53% is possible with a carbon to oxygen ratio of 0.7. Higher efficiencies are possible (up to 71%) when higher C/O ratios are used, provided that olefin production can be minimized in the CPO reactor. (C) 2008 Elsevier B.V. All rights reserved. C1 [Hohn, Keith L.] Kansas State Univ, Dept Chem Engn, Manhattan, KS 66506 USA. [DuBois, Terry] USA, Commun Elect Command Res Dev & Engn Ctr, Ft Belvoir, VA 22060 USA. RP Hohn, KL (reprint author), Kansas State Univ, Dept Chem Engn, 1005 Durland Hall, Manhattan, KS 66506 USA. EM hohn@ksu.edu; terry.dubois@us.army.mil NR 21 TC 5 Z9 5 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD AUG 15 PY 2008 VL 183 IS 1 BP 295 EP 302 DI 10.1016/j.jpowsour.2008.04.029 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 354SM UT WOS:000259659300039 ER PT J AU Dey, B Zhou, YX Jeelani, S Kumar, A Stephenson, LD AF Dey, B. Zhou, Yuanxin Jeelani, Shaik Kumar, Ashok Stephenson, L. D. TI Nonlinear constitutive equation for temperature degraded unidirectional carbon fiber reinforced epoxy SO MATERIALS LETTERS LA English DT Article DE carbon/epoxy composite; degradation; damage model ID MONTE-CARLO SIMULATION; COMPOSITES; STRENGTH; FAILURE; MODEL AB In this study, unidirectional carbon fiber reinforced epoxy was made by vacuum-assisted resin transfer molding (VARTM). Accelerated tests have been conducted on resulting composites at different temperature and different time. Flexural tests results show that modulus and strength decreased with increasing of time and temperature. Based on the experimental result, a linear damage model has been combined with the Weibull distribution function to establish a constitutive equation for carbon/epoxy composite. The parameters in this model are the modulus E, the Weibull shape parameter and Weibull scale parameter. The simulated stress-strain curves from the model are in good agreement with the test data. All three parameters were found to be temperature and time dependent. (c) 2008 Elsevier B.V. All rights reserved. C1 [Dey, B.; Zhou, Yuanxin; Jeelani, Shaik] Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. [Kumar, Ashok; Stephenson, L. D.] USA, Corps Engineers, Engn Res & Develop Ctr, Washington, DC USA. RP Zhou, YX (reprint author), Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. EM yzhou@tuskegee.edu NR 6 TC 1 Z9 1 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X J9 MATER LETT JI Mater. Lett. PD AUG 15 PY 2008 VL 62 IS 21-22 BP 3659 EP 3662 DI 10.1016/j.matlet.2008.04.024 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 326DS UT WOS:000257639000017 ER PT J AU Picchioni, D Fukunaga, M Carr, WS Braun, AR Balkin, TJ Duyn, JH Horovitz, SG AF Picchioni, Dante Fukunaga, Masaki Carr, Walter S. Braun, Allen R. Balkin, Thomas J. Duyn, Jeff H. Horovitz, Silvina G. TI fMRI differences between early and late stage-1 sleep SO NEUROSCIENCE LETTERS LA English DT Article DE fMRI; EEG; stage-1 sleep; sleep scoring; sleep onset ID FLUCTUATIONS AB This study sought to test for differences in regional brain activity between stage-1 sleep immediately following wake and immediately preceding stage-2 sleep. Data were collected during daytime fMRI sessions with simultaneous EEG acquisition. A stage-1 interval was defined as follows: >= 30 s of wake, immediately followed by >= 60 s of continuous stage 1, immediately followed by >= 30 s of stage 2. We compared brain activity between the first 30 s of stage 1 (early stage 1), the last 30 s of stage 1 (late stage 1), and isolated wake. A conjunction analysis sorted each voxel into one of a series of mutually exclusive categories that represented the various possible combinations of a significant increase, decrease, or no difference among these three states. The initial dataset consisted of 14 healthy volunteers. A total of 22 sessions in these participants yielded six stage-1 intervals (from four participants) that met criteria for inclusion in the analysis. There were multiple clusters of significant voxels. Examples include changes in default-mode network areas where activity increased compared to wake only in early stage 1 and a bilateral change in the hippocampus where activity increased compared to wake only in late stage 1. These results suggest that activity in anatomically identifiable, volumetric brain regions exhibit differences during stage-1 sleep that would not have been detected with the EEG. These differences may also have specific relevance to understanding the process of sleep onset as well as the neural mechanisms of performance lapses during sleep deprivation. Published by Elsevier Ireland Ltd. C1 [Picchioni, Dante; Balkin, Thomas J.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Fukunaga, Masaki; Duyn, Jeff H.; Horovitz, Silvina G.] NINDS, Natl Inst Hlth, Bethesda, MD USA. [Carr, Walter S.] USN, Med Ctr, Bethesda, MD 20814 USA. [Braun, Allen R.] Natl Inst Deafness & Other Commun Disorders, Natl Inst Hlth, Bethesda, MD 20892 USA. RP Picchioni, D (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM dante.picchioni@amedd.army.mil RI Duyn, Jozef/F-2483-2010 FU Intramural NIH HHS [Z99 DC999999] NR 13 TC 22 Z9 22 U1 1 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD AUG 15 PY 2008 VL 441 IS 1 BP 81 EP 85 DI 10.1016/j.neulet.2008.06.010 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 333TD UT WOS:000258174400017 PM 18584959 ER PT J AU Xu, ZY Ding, HP Sadler, BM Chen, G AF Xu, Zhengyuan Ding, Haipeng Sadler, Brian M. Chen, Gang TI Analytical performance study of solar blind non-line-of-sight ultraviolet short-range communication links SO OPTICS LETTERS LA English DT Article ID LIGHT-EMITTING-DIODES; AVALANCHE PHOTODIODES; SCATTERING AB Motivated by recent advances in solid-state incoherent ultraviolet sources and solar blind detectors, we study communication link performance over a range of less than I kin with a bit error rate (BER) below 10(-3) in solar blind non-line-of-sight situation. The widely adopted yet complex single scattering channel model is significantly simplified by means of a closed-form expression for tractable analysis. Path loss is given as a function of transceiver geometry as well as atmospheric scattering and attenuation and is compared with experimental data for model validation. The BER performance of a shot-noise-limited receiver under this channel model is demonstrated. (C) 2008 Optical Society of America. C1 [Xu, Zhengyuan; Ding, Haipeng; Chen, Gang] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] USA, Res Lab, AMSRD ARL CI NT, Adelphi, MD 20783 USA. RP Xu, ZY (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu RI Ding, Haipeng/B-7742-2014 FU Army Research Office [W911NF-06-1-0364, W911NF-06-1-0173]; Army Research Laboratory [DAAD19-01-2-0011] FX This research was supported in part by the Army Research Office under grants W911NF-06-1-0364 and W911NF-06-1-0173, and the Army Research Laboratory under the Collaborative Technology Allianced Program, cooperative agreement DAAD19-01-2-0011. NR 16 TC 89 Z9 110 U1 1 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 EI 1539-4794 J9 OPT LETT JI Opt. Lett. PD AUG 15 PY 2008 VL 33 IS 16 BP 1860 EP 1862 DI 10.1364/OL.33.001860 PG 3 WC Optics SC Optics GA 347BH UT WOS:000259113300029 PM 18709113 ER PT J AU Anzinger, JJ Olinger, GG Spear, GT AF Anzinger, Joshua J. Olinger, Gene G. Spear, Gregory T. TI Donor variability in HIV binding to peripheral blood mononuclear cells SO VIROLOGY JOURNAL LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELLS; INFECTION; RECEPTORS; MACROPHAGES; ENTRY AB Background: HIV infection of cells varies greatly between individuals, with multiple steps in the replication cycle potentially contributing to the variability. Although entry and post-entry variability of HIV infection levels in cells has been demonstrated, variability in HIV binding has not been examined. In this study, we examined variability of HIV binding to peripheral blood mononuclear cells (PBMC) from different donors. Results: HIV binding to PBMC varied up to 3.9-fold between individuals and was independent of CD4. Replication of HIV in donor PBMC required CD4 and paralleled virus binding trends of donor PBMC. To assess the stability of virus binding phenotypes over time, HIV was bound to donors with low- and high-binding phenotypes. The binding phenotypes were maintained when tested weekly over a 4-week period for 3 of 4 donors, while one high-binding donor decreased to lower binding on the 4th week. The low- and high-binding phenotypes were also preserved across different HIV strains. Experiments performed to determine if there was an association between HIV binding levels and specific cell subset levels within PBMC showed no correlation, suggesting that HIV binds to multiple cell subsets. Conclusion: These results show that differences exist in HIV binding to donor PBMC. Our data also show that HIV binding to donor PBMC is CD4-independent and can change over time, suggesting that virus binding variability is due to differences in the expression of changeable cellsurface host factors. Taken together, this study highlights the impact of cell-surface factors in HIV binding to, and infection of, PBMC which likely represents an important step in HIV infection in vivo. C1 [Anzinger, Joshua J.] NHLBI, Sect Expt Atherosclerosis, NIH, Bethesda, MD 20892 USA. [Olinger, Gene G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Spear, Gregory T.] Rush Univ, Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60612 USA. RP Anzinger, JJ (reprint author), NHLBI, Sect Expt Atherosclerosis, NIH, 10 Ctr Dr,Bldg 10,Room 5N111, Bethesda, MD 20892 USA. EM anzingerjj@nhlbi.nih.gov; gene.olinger@us.army.mil; gspear@rush.edu OI Olinger, Gene/0000-0001-7338-0292 FU National Institutes of Health [P01HD40539] FX This work was supported by National Institutes of Health grant P01HD40539. NR 19 TC 3 Z9 3 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD AUG 15 PY 2008 VL 5 AR 95 DI 10.1186/1743-422X-5-95 PG 6 WC Virology SC Virology GA 360AG UT WOS:000260028800001 PM 18706090 ER PT J AU Solaja, BA Opsenica, D Smith, KS Milhous, WK Terzic, N Opsenica, I Burnett, JC Nuss, J Gussio, R Bavari, S AF Solaja, Bogdan A. Opsenica, Dejan Smith, Kirsten S. Milhous, Wilbur K. Terzic, Natasa Opsenica, Igor Burnett, James C. Nuss, Jon Gussio, Rick Bavari, Sina TI Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID ANTIMALARIAL ACTIVITY; SIDE-CHAIN; PLASMODIUM-FALCIPARUM; NEUROTOXIN; DERIVATIVES; METALLOPROTEASE; CANDIDATE; MALARIA AB We report on the initial result of the coupling of 4-amino7-chloroquinoline with steroidal and adamantane constituents to provide small molecules with excellent in vitro antimalarial activities (IC90 (W2) down to 6.74 nM). The same entities also inhibit the botulinum neurotoxin serotype A light chain metalloprotease at low nlicromolar levels (7-3 1 yM). Interestingly. structural features imparting increased antimalarial activity also provide increased inetalloprotease inhibition, thus allowing for simultaneous compound optimizations against distinct targets. C1 [Solaja, Bogdan A.; Terzic, Natasa; Opsenica, Igor] Univ Belgrade, Fac Chem, Belgrade 11001, Serbia. [Opsenica, Dejan; Bavari, Sina] Inst Chem Technol & Met, Belgrade 11000, Serbia. [Smith, Kirsten S.; Milhous, Wilbur K.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. [Burnett, James C.] SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Frederick, MD USA. Frederick Inc, Natl Canc Inst, Frederick, MD 21702 USA. [Gussio, Rick] Natl Canc Inst, Dev Therapeut Program, Frederick, MD 21702 USA. [Nuss, Jon] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 158, Belgrade 11001, Serbia. EM bsolaja@chem.bg.ac.yu RI Opsenica, Igor/P-5308-2016; OI Opsenica, Igor/0000-0003-4942-4042; Solaja, Bogdan/0000-0002-9975-2725 FU NCI NIH HHS [Y3-CM-100505] NR 26 TC 34 Z9 36 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD AUG 14 PY 2008 VL 51 IS 15 BP 4388 EP 4391 DI 10.1021/jm800737y PG 4 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 335KP UT WOS:000258289800007 PM 18637666 ER PT J AU Liu, F Stephen, AG Waheed, AA Aman, MJ Freed, EO Fisher, RJ Burke, TR AF Liu, Fa Stephen, Andrew G. Waheed, Abdul A. Aman, M. Javad Freed, Eric O. Fisher, Robert J. Burke, Terrence R., Jr. TI SAR by oxime-containing peptide libraries: Application to Tsg101 ligand optimization SO CHEMBIOCHEM LA English DT Article DE aldehydes; combinatorial chemistry; oximes; peptidomimetics; Tsg101 ID PROTEIN-PROTEIN INTERACTIONS; UEV DOMAIN; ANTAGONISTS; DESIGN; CHEMOTHERAPY; RECOGNITION; INHIBITION; TARGETS; POTENT AB HIV-1 viral assembly requires a direct interaction between a Pro-Thr-Ala-Pro ("PTAP") motif in the viral protein Gag-p6 and the cellular endosomal sorting factor Tsg101. In an effort to develop competitive inhibitors of this interaction, an SAR study was conducted based on the application of post solid-phase oxime formation involving the sequential insertion of aminooxy-containing residues within a nonamer parent, peptide followed by reaction with libraries of aldehydes. Approximately 15-20-fold enhancement in binding affinity was achieved by this approach. C1 [Liu, Fa; Burke, Terrence R., Jr.] NCI, Med Chem Lab, CCR, Frederick, MD 21702 USA. [Stephen, Andrew G.; Fisher, Robert J.] SAIC, Adv Technol Program, Prot Chem Lab, Frederick, MD 21702 USA. [Waheed, Abdul A.; Freed, Eric O.] NCI, HIV Drug Resistance Program, CCR, Frederick, MD 21702 USA. [Aman, M. Javad] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Burke, TR (reprint author), NCI, Med Chem Lab, CCR, Bldg 376 Boyles St, Frederick, MD 21702 USA. EM tburke@helix.nih.gov RI Fisher, Robert/B-1431-2009; Burke, Terrence/N-2601-2014 FU Intramural Research Program of the NIH; Center for Cancer Research; NCI-Frederick; National Cancer Institute; National Institutes of Health [N01-CO-12400] FX The Work was supported in part by the Intramural Research Program of the NIH, Center for Cancer Research, NCI-Frederick, and the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, neither does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. NR 24 TC 18 Z9 18 U1 0 U2 0 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1439-4227 J9 CHEMBIOCHEM JI ChemBioChem PD AUG 11 PY 2008 VL 9 IS 12 BP 2000 EP 2004 DI 10.1002/cbic.200800281 PG 5 WC Biochemistry & Molecular Biology; Chemistry, Medicinal SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 339OJ UT WOS:000258586600022 PM 18655064 ER PT J AU Peirson, WL Garcia, AW AF Peirson, William L. Garcia, Andrew W. TI On the wind-induced growth of slow water waves of finite steepness SO JOURNAL OF FLUID MECHANICS LA English DT Article ID SHORT GRAVITY-WAVES; TURBULENT AIR-FLOW; BREAKING WAVES; CAPILLARY WAVES; SURFACE-WAVE; LABORATORY MEASUREMENTS; GENERATED WAVES; DEEP-WATER; FIELD-MEASUREMENTS; RAPID-DISTORTION AB Determining characteristic growth rates for water waves travelling more slowly than the wind has continued to be a key unresolved problem of air-sea interaction for over half a century. Analysis of previously reported and recently acquired laboratory wave data shows a systematic decline in normalized wave growth with increasing mean wave steepness that has not previously been identified. The normalized growth dynamic range is comparable with previously observed scatter amongst other laboratory data gathered in the slow wave range. Strong normalized growth rates are observed at low wave steepnesses, implying an efficient wave-coherent tangential stress contribution. Data obtained during this study show quantitative agreement with the predictions of others of the interactions between short wind waves and the longer lower-frequency waves. Measured normalized wave growth rates are consistent with numerically predicted growth due to wave drag augmented by significant wave-coherent tangential stress. C1 [Peirson, William L.] Univ New S Wales, Sch Civil & Environm Engn, Water Res Lab, King, NSW 2093, Australia. [Garcia, Andrew W.] USA, Coastal & Hydraul Lab, Ctr Res Dev & Engn, Vicksburg, MS USA. RP Peirson, WL (reprint author), Univ New S Wales, Sch Civil & Environm Engn, Water Res Lab, King St,Manly Vale, King, NSW 2093, Australia. EM W.Peirson@unsw.edu.au OI Peirson, William/0000-0001-8775-5200 NR 75 TC 22 Z9 22 U1 1 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD AUG 10 PY 2008 VL 608 BP 243 EP 274 DI 10.1017/S002211200800205X PG 32 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 334DG UT WOS:000258201900011 ER PT J AU Li, YJ Pritchett, TM Huang, JD Ke, MR Shao, P Sun, WF AF Li, Yunjing Pritchett, Timothy M. Huang, Jiandong Ke, Meirong Shao, Pin Sun, Wenfang TI Photophysics and nonlinear absorption of peripheral-substituted zinc phthalocyanines SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID FIELD-EFFECT TRANSISTORS; OCTADECYLSILOXY)SILICON 2,3-NAPHTHALOCYANINE ISOBOSINC; REVERSE SATURABLE ABSORPTION; INDIUM PHTHALOCYANINES; PHOTODYNAMIC THERAPY; OXYGEN; SINGLET; PHOTOSENSITIZERS; NAPHTHALOCYANINES; METALLOPHTHALOCYANINES AB The photophysical properties, such as the UV-vis absorption spectra, triplet transient difference absorption spectra, triplet excited-state extinction coefficients, quantum yields of the triplet excited state, and lifetimes of the triplet excited state, of 10 novel zinc phthalocyanine derivatives with mono- or tetraperipheral substituents have been systematically investigated in DMSO solution. All these complexes exhibit a wide optical window in the visible spectral range and display long triplet excited-state lifetimes (140-240 mu s). It has been found that the complexes with tetrasubstituents at the alpha-positions exhibit a bathochromic shift in their UV-vis absorption spectra, fluorescence spectra, and triplet transient difference absorption spectra and have larger triplet excited-state absorption coefficients. The nonlinear absorption of these complexes has been investigated using the Z-scan technique. It is revealed that all complexes exhibit a strong reverse saturable absorption at 532 nm for nanosecond and picosecond laser pulses. The excited-state absorption cross sections were deten-nined through a theoretical fitting of the experimental data using a five-band model. The complexes with tetrasubstituents at the alpha-positions exhibit larger ratios of triplet excited-state absorption to ground-state absorption cross sections (sigma(T)/sigma(g)) than the other complexes. In addition, the wavelength-dependent nonlinear absorption of these complexes was studied in the range of 470-550 nm with picosecond laser pulses. All complexes exhibit reverse saturable absorption in a broad visible spectral range for picosecond laser pulses. Finally, the nonlinear transmission behavior of these complexes for nanosecond laser pulses was demonstrated at 532 nm. All complexes, and especially the four alpha-tetrasubstituted complexes, exhibit stronger reverse saturable absorption than unsubstituted zinc plithalocyanines due to the larger ratio of their excited-state absorption cross sections to their respective ground-state absorption cross sections. C1 [Li, Yunjing; Shao, Pin; Sun, Wenfang] N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58105 USA. [Pritchett, Timothy M.] USA, Res Lab, AMSRD ARL SE EM, Adelphi, MD 20783 USA. [Huang, Jiandong; Ke, Meirong] Fuzhou Univ, Coll Chem & Chem Engn, Fuzhou 350002, Peoples R China. RP Sun, WF (reprint author), N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58105 USA. EM Wenfang.Sun@ndsu.edu RI shao, pin/D-5790-2011 NR 48 TC 51 Z9 52 U1 0 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD AUG 7 PY 2008 VL 112 IS 31 BP 7200 EP 7207 DI 10.1021/jp7108835 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 332QI UT WOS:000258097800011 PM 18616331 ER PT J AU Wagner, GW Chen, Q Wu, Y AF Wagner, George W. Chen, Qiang Wu, Yue TI Reactions of VX, GD, and HD with nanotubular titania SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID NANOSIZE AL2O3; DECONTAMINATION; HYDROLYSIS; AGENTS; TIO2; P-31 AB Reactions of VX [O-ethyl-S-(2-diisopropylethylamino)ethyl methylphosphonothioate], GD (pinacolyl methylphosphonofluoridate), and HD [bis(2-chloroethyl) sulfide] have been examined with nanotubular titania (NTT) using P-31 and C-13 MAS NMR. All three agents hydrolyze on NTT with the reaction of VX being notably fast (t(1/2) < 30 min), approaching the rate achievable with liquid decontaminants. IT MAS NMR reveals that VX is adsorbed within the NTT tubules and/or its titania layers, perhaps providing optimum conditions for its hydrolysis by water sandwiched between the layers. Consistent with the availability of copious water on NTT, HD is hydrolyzed to its CH-TG sulfonium ion. GD hydrolysis is similarly efficient, with its products-PMPA and HF-attacking the titania structure to form a titanophosphonate species. C1 [Wagner, George W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Chen, Qiang; Wu, Yue] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA. [Chen, Qiang; Wu, Yue] Univ N Carolina, Curriculum Appl & Mat Sci, Chapel Hill, NC 27599 USA. RP Wagner, GW (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM george.wagner@rdecom.agpea.army.mil NR 21 TC 32 Z9 35 U1 1 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD AUG 7 PY 2008 VL 112 IS 31 BP 11901 EP 11906 DI 10.1021/jp803003k PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 333IW UT WOS:000258147200044 ER PT J AU Brantley, CG Day, JW Lane, RR Hyfield, E Day, JN Ko, JY AF Brantley, Christopher G. Day, John W., Jr. Lane, Robert R. Hyfield, Emily Day, Jason N. Ko, Jae-Young TI Primary production, nutrient dynamics, and accretion of a coastal freshwater forested wetland assimilation system in Louisiana SO ECOLOGICAL ENGINEERING LA English DT Article DE nutrients; loading rate; retention time; wastewater treatment; wetlands; forest productivity; Louisiana; USA ID BALDCYPRESS TAXODIUM-DISTICHUM; MISSISSIPPI RIVER-BASIN; DELTA; MARSH; DECOMPOSITION; WASTEWATER; EFFLUENT; NITROGEN; REMOVAL; QUALITY AB This study reports on the response of a tidal, freshwater forested wetland ecosystem to long-term input of secondarily treated municipal effluent from the City of Mandeville, LA. Measurements of hydrology, nutrients, and aboveground net primary productivity were made from September 1998 through March 2002. Accretion measurements were made in October 2000 and October 2004. The major hydrologic inputs to the system were the effluent, precipitation, and back water flooding from Lake Pontchartrain. Nutrient levels were generally low except in the immediate vicinity of the outfall. Mean net primary production of the freshwater forest system was significantly higher downstream of the effluent discharge (1202 g m(-2) yr(-1)) compared to the control site (799 g m(-2) yr(-1)). Downstream of the outfall, accretion rates were double the rate of relative sea level rise in the area. Removal efficiencies of N and P were as high as 75% and 95%, respectively. The relatively constant flow of secondarily treated municipal effluent buffered the downstream area from salinity intrusion during a region-wide drought. Re-direction of nutrient-enhanced effluents from open water bodies to wetland ecosystems can maintain plant productivity, sequester carbon, and maintain coastal wetland elevations in response to sea-level rise in addition to improving overall surface water quality, reducing energy use, and increasing financial savings. Published by Elsevier B.V. C1 [Brantley, Christopher G.] USA, Corps Engineers, New Orleans, LA 70160 USA. [Brantley, Christopher G.; Day, John W., Jr.; Lane, Robert R.; Hyfield, Emily; Day, Jason N.; Ko, Jae-Young] Louisiana State Univ, Sch Coast & Enuironment, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. RP Brantley, CG (reprint author), USA, Corps Engineers, New Orleans Dist,POB 60267, New Orleans, LA 70160 USA. EM Christopher.G.Brantley@mvn02.usace.army.mil FU City of Mandeville, FX This study was funded by the City of Mandeville, LA. We acknowledge support of the personnel of the Department of Public Works of Mandeville, especially Mr. Joe Mistich. C. Coronado, B. Perez, R. Pratt and A. Westphal provided help in the field and laboratory. We appreciate the review of the manuscript by P. Templet, D. Justic, J. Cable and M. Levitan. NR 97 TC 22 Z9 24 U1 3 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0925-8574 J9 ECOL ENG JI Ecol. Eng. PD AUG 4 PY 2008 VL 34 IS 1 BP 7 EP 22 DI 10.1016/j.ecoleng.2008.05.004 PG 16 WC Ecology; Engineering, Environmental; Environmental Sciences SC Environmental Sciences & Ecology; Engineering GA 351FT UT WOS:000259410600002 ER PT J AU Vandre, E Maier, RS Kroll, DM McCormick, A Davis, HT AF Vandre, Eric Maier, Robert S. Kroll, Daniel M. McCormick, Alon Davis, H. Ted TI Diameter-dependent dispersion in cylindrical bead packs SO AICHE JOURNAL LA English DT Article DE chromatography; fluid mechanics; separation techniques ID BEDS; COLUMN; FLOW AB It has recently been argued that longitudinal dispersion in cylindrical packed beds is enhanced due to radial heterogeneities in the porosity and resulting velocity field. In particular, it is predicted that the time scale to attain asymptotic dispersion in a packed bed of radius R is proportional to R 2 IDT, where DT is the transverse dispersion constant in a homogeneous beadpack, and that the asymptotic longitudinal dispersion constant increases with Rld, where d is the bead diameter. We have measured the asymptotic dispersion rates for packed beds with R/d = 9.5, 12.7, and 25.4 and find good qualitative agreement with the predicted dependence on R/d. (c) 2008 American Institute of Chemical Engineers. C1 [Vandre, Eric; McCormick, Alon; Davis, H. Ted] Univ Minnesota, Dept Chem Engn & Mat Sci, Minneapolis, MN 55455 USA. [Maier, Robert S.] USA, Engn Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. [Kroll, Daniel M.] N Dakota State Univ, Dept Phys, Fargo, ND 58105 USA. RP Davis, HT (reprint author), Univ Minnesota, Dept Chem Engn & Mat Sci, 421 Washington Ave SE, Minneapolis, MN 55455 USA. EM davis@cems.umn.edu NR 12 TC 8 Z9 8 U1 1 U2 8 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0001-1541 J9 AICHE J JI AICHE J. PD AUG PY 2008 VL 54 IS 8 BP 2024 EP 2028 DI 10.1002/aic.11529 PG 5 WC Engineering, Chemical SC Engineering GA 336TV UT WOS:000258388400007 ER PT J AU Vahey, MT Wang, ZN Su, ZH Nau, ME Krambrink, A Skiest, DJ Margolis, DM AF Vahey, Maryanne T. Wang, Zhining Su, Zhaohui Nau, Martin E. Krambrink, Amy Skiest, Daniel J. Margolis, David M. TI CD4(+) T-Cell Decline after the Interruption of Antiretroviral Therapy in ACTG A5170 Is Predicted by Differential Expression of Genes in the Ras Signaling Pathway SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID STRUCTURED TREATMENT INTERRUPTIONS; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTED PATIENTS; SOCIETY-USA PANEL; RAS/RAF/MEK/ERK PATHWAY; TREATMENT FAILURE; TYPE-1 INFECTION; RANDOMIZED-TRIAL; DYNAMICS; PROGRESSION AB Patterns of expressed genes examined in cryopreserved peripheral blood mononuclear cells (PBMCs) of seropositive persons electing to stop antiretroviral therapy in the AIDS Clinical Trials Group Study A5170 were scrutinized to identify markers capable of predicting the likelihood of CD4(+) T-cell depletion after cessation of antiretroviral therapy (ART). A5170 was a multicenter, 96-week, prospective study of HIV-infected patients with immunological preservation on ART who elected to interrupt therapy. Study entry required that the CD4 count was greater than 350 cells/mm(3) within 6 months of ART initiation. Median nadir CD4 count of enrollees was 436 cells/mm(3). Two cohorts, matched for clinical characteristics, were selected from A5170. Twenty-four patients with an absolute CD4 cell decline of less that 20% at week 24 (good outcome group) and 24 with a CD4 cell decline of >20% (poor outcome group) were studied. The good outcome group had a decline in CD4(+) T-cell count that was 50% less than the poor outcome group. Significance analysis of microarrays identified differential gene expression (DE) in the two groups in data obtained from Affymetrix Human FOCUS GeneChips. DE was significantly higher in the poor outcome group than in the good outcome group. Prediction analysis of microarrays (PAM-R) identified genes that classified persons as to progression with greater than 80% accuracy at therapy interruption (TI) as well as at 24 weeks after TI. Gene set enrichment analysis (GSEA) identified a set of genes in the Ras signaling pathway, associated with the downregulation of apoptosis, as significantly upregulated in the good outcome group at cessation of ART. These observations identify specific host cell processes associated with differential outcome in this cohort after TI. C1 [Vahey, Maryanne T.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. [Wang, Zhining; Nau, Martin E.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA. [Su, Zhaohui; Krambrink, Amy] Harvard Univ, Sch Publ Hlth, Stat & Data Anal Ctr, Boston, MA 02115 USA. [Skiest, Daniel J.] Baystate Med Ctr, Springfield, MA USA. [Skiest, Daniel J.] Tufts Univ, Sch Med, Medford, MA 02155 USA. [Margolis, David M.] Univ N Carolina, Dept Med, Chapel Hill, NC USA. RP Vahey, MT (reprint author), US Mil HIV Res Program, Div Retrovirol, 1600 E Gude Dr, Rockville, MD 20850 USA. EM mvahey@hivresearch.org OI Margolis, David/0000-0001-5714-0002 FU U.S. Army Medical Research and Materiel Command [W81XWH-04-2-0005]; Henry M. Jackson Foundation; National Institute of Allergy and Infectious Disease [5U01 AI38855, AI-68636, AI025915, AI027666, AI27670, AI25897, AI25868, RR00046, AI50410, AI46386, RR00047, AI 27665, RR00096, AI 27664, AI46381, AI032783, AI045008, AI27660, AI46370, AI 27673, A125903, AI27658, RR00044, AI27661, AI39156, AI25859] FX We thank M. Pochyla for expert technical laboratory work and Dr. Gustavo Kijak and Mr. Eric Sanders-Buell, all of the Henry M. Jackson Foundation, for advice on the design and execution of RT-PCR. We also thank Dr. Jerome Kim, Armed Forces Research Institute of the Medical Sciences, Bangkok, for helpful advice in the initial stages of this work and Dr. Emil Lesho, Walter Reed Army Institute of Research, for scrutiny of the final draft. This work was supported in part by Cooperative Agreement no. W81XWH-04-2-0005 between the U.S. Army Medical Research and Materiel Command and the Henry M. Jackson Foundation for the Advancement of Military Medicine. This work was supported by the Statistical and Data Management Center under the National Institute of Allergy and Infectious Disease grant no. 5U01 AI38855 and in part by the AIDS Clinical Trials Group funded by the National Institute of Allergy and Infectious Diseases grant no. AI-68636. The parent ACTG study from which these samples were derived, was funded by grants: AI025915, AI027666, AI27670, AI25897, AI25868, RR00046, AI50410, AI46386, RR00047, AI 27665, RR00096, AI 27664, AI46381, AI032783, AI045008, AI27660, AI46370, AI 27673, A125903, AI27658, RR00044, AI27661, AI39156, and AI25859. NR 41 TC 4 Z9 4 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 2008 VL 24 IS 8 BP 1047 EP 1066 DI 10.1089/aid.2008.0059 PG 20 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 347GK UT WOS:000259128400006 PM 18724805 ER PT J AU Okoh, EJ Bucci, JR Simon, JF Harrison, SA AF Okoh, Emuejevoke J. Bucci, Jay R. Simon, James F. Harrison, Stephen A. TI HCV in patients with end-stage renal disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Review ID HEPATITIS-C-VIRUS; KIDNEY-TRANSPLANT CANDIDATES; INTERFERON-ALPHA TREATMENT; SINGLE-CENTER EXPERIENCE; HEMODIALYSIS-PATIENTS; DIALYSIS PATIENTS; ALLOGRAFT RECIPIENTS; ORGAN-TRANSPLANTATION; PEGYLATED-INTERFERON; LIVER FIBROSIS AB Chronic hepatitis C virus (HCV) infection remains an important cause of liver disease in patients with end-stage renal disease (ESRD) and conversely, renal failure has a significant impact on morbidity and mortality throughout the natural history of chronic HCV and its treatment. With improved awareness within dialysis units of the potential for spread and the institution of preventative measures, the prevalence of HCV infection in the hemodialysis-dependent population has continued to decline since 1995. Use of HCV (+) donor kidneys is associated with an increase in the prevalence of liver disease, but when compared with continued hemodialysis, transplantation using these kidneys is associated with improved survival. Overall, survival in patients with chronic HCV infection appears to be better after renal transplantation when compared with maintenance hemodialysis, and transplant should be considered for these patients. Data support the use of interferon and the improved efficacy of pegylated interferon formulations for treatment of chronic HCV infection in ESRD patients, although tolerability continues to be troublesome. The newest and most promising data regarding the treatment of HCV in ESRD involve the combination of reduced dose ribavirin with interferon or pegylated interferon suggesting similar enhancements in sustained virologic response (SVR) as seen in non-ESRD patients, but caution is advised, as all studies to date used ribavirin plasma concentration monitoring in patient with ESRD. Finally, with regard to postrenal transplant treatment of HCV infection, there is no evidence to support treatment with interferon-based therapy and pretransplant treatment remains the best option whenever possible. C1 [Okoh, Emuejevoke J.; Bucci, Jay R.; Simon, James F.; Harrison, Stephen A.] Brooke Army Med Ctr, Dept Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 105 TC 14 Z9 14 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD AUG PY 2008 VL 103 IS 8 BP 2123 EP 2134 DI 10.1111/j.1572-0241.2008.01981.x PG 12 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 335GG UT WOS:000258278200034 PM 18796105 ER PT J AU Ally, MR Veerappan, GR Koff, JM AF Ally, Mazer R. Veerappan, Ganesh R. Koff, Jonathan M. TI Treatment of recurrent Crohn's uveitis with infliximab SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Letter ID INFLAMMATORY-BOWEL-DISEASE; NECROSIS-FACTOR-ALPHA; REFRACTORY POSTERIOR UVEITIS; EXTRAINTESTINAL MANIFESTATIONS; OCULAR INFLAMMATION; CHILDHOOD UVEITIS; THERAPY; MANAGEMENT; EFFICACY; TERM C1 [Veerappan, Ganesh R.; Koff, Jonathan M.] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. [Ally, Mazer R.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Ally, Mazer R.; Veerappan, Ganesh R.; Koff, Jonathan M.] Univ Hlth Sci, Uniformed Serv, Bethesda, MD USA. RP Ally, MR (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. NR 26 TC 10 Z9 10 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD AUG PY 2008 VL 103 IS 8 BP 2150 EP 2151 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 335GG UT WOS:000258278200047 PM 18796120 ER PT J AU Brunetti-Pierri, N Sahoo, T Frioux, S Chinault, C Zascavage, R Cheung, SW Peters, S Shinawi, M AF Brunetti-Pierri, Nicola Sahoo, Trilochan Frioux, Sarah Chinault, Craig Zascavage, Roxanne Cheung, Sau-Wai Peters, Sarika Shinawi, Marwan TI 15q13q14 deletions: Phenotypic characterization and molecular delineation by comparative genomic hybridization SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A LA English DT Article DE 15q13q14; Prader-Willi/Angelman syndrome; array-CGH; mental retardation ID PRADER-WILLI-SYNDROME; CARDIAC ACTIN GENE; MENTAL-RETARDATION; DILATED CARDIOMYOPATHY; INTERSTITIAL DELETION; ANGELMAN-SYNDROME; 15Q DELETION; PROXIMAL 15Q; TRANSLOCATION; EXPRESSION AB We report on a detailed phenotypic characterization of two patients with novel de novo deletions involving 15q13q14, a chromosomal region immediately distal to the Prader-Willi/Angelman syndrome critical interval. Both cases were detected by the clinical array-based comparative genomic hybridization (array-CGH) and were precisely delineated through the high-density Agilent 244 K oligonucleotide array. The comparision of our patients with previously reported deletion cases involving the 15q13q14 region demonstrated a recurrent pattern of developmental anomalies including mild dysmorphic features, cleft palate/bifiduvula, congenital heart defects (PFO or ASD), developmental delay, and learning disabilities. The potential role of the genes within the deleted region in the pathogenesis of these various phenotypic abnormalities is discussed. (c) 2008 Wiley-Liss, Inc. C1 [Brunetti-Pierri, Nicola; Sahoo, Trilochan; Chinault, Craig; Zascavage, Roxanne; Cheung, Sau-Wai; Peters, Sarika; Shinawi, Marwan] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA. [Brunetti-Pierri, Nicola; Sahoo, Trilochan; Chinault, Craig; Zascavage, Roxanne; Cheung, Sau-Wai; Peters, Sarika; Shinawi, Marwan] Texas Childrens Hosp, Houston, TX 77030 USA. [Sahoo, Trilochan; Chinault, Craig; Cheung, Sau-Wai] Baylor Coll Med, Med Genet Labs, Houston, TX 77030 USA. [Frioux, Sarah] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Peters, Sarika] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA. RP Shinawi, M (reprint author), Baylor Coll Med, Dept Mol & Human Genet, 1 Baylor Plaza,Room T619, Houston, TX 77030 USA. EM mshinawi@bcm.tmc.edu RI Brunetti-Pierri, Nicola/K-8465-2016; OI Brunetti-Pierri, Nicola/0000-0002-6895-8819; shinawi, Marwan /0000-0003-1329-4100 NR 45 TC 4 Z9 4 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1552-4825 J9 AM J MED GENET A JI Am. J. Med. Genet. A PD AUG 1 PY 2008 VL 146A IS 15 BP 1933 EP 1941 DI 10.1002/ajmg.a.32324 PG 9 WC Genetics & Heredity SC Genetics & Heredity GA 338AI UT WOS:000258476800005 PM 18561338 ER PT J AU Bidus, MA Caffrey, AS You, WB Amezcua, CA Chernofsky, MR Barner, R Seidman, J Rose, GS AF Bidus, Michael A. Caffrey, Angela S. You, Whitney B. Amezcua, Charles A. Chernofsky, Mildred R. Barner, Ross Seidman, Jeffrey Rose, G. Scott TI Cervical biopsy and excision procedure specimens lack sufficient predictive value for lymph-vascular space invasion seen at hysterectomy for cervical cancer SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE cervix cancer; lymph-vascular space invasion (LVSI) ID RADICAL HYSTERECTOMY; PROGNOSTIC-FACTORS; ENDOMETRIAL CANCER; RADIOTHERAPY; CHEMOTHERAPY; SURVIVAL; SURGERY AB OBJECTIVE: The purpose of this study was to determine whether lymph-vascular space invasion (LVSI) that is discovered in cervical biopsy and excision specimens is associated with LVSI in the hysterectomy specimen of patients with cervical cancer. STUDY DESIGN: A retrospective pathologic review to determine the presence of LVSI in cervical biopsy specimens, cold-knife cone biopsy (CKC biopsy), and loop electrical excision procedure (LEEP) specimens that contained cervical cancer was performed if subsequent hysterectomy results were available for review. Data were analyzed with chi-square analysis testing. RESULTS: One hundred six patients were identified. The negative predictive value of the biopsy is lower at 0.45 than either the CKC biopsy (0.83) or LEEP (0.57); however, the positive predictive value (0.83) is higher than either CKC biopsy (0.50) or LEEP (0.75). LVSI, when present in cervical biopsy (odds ratio, 4.13; 95% CI, 0.414-98.446), CKC biopsy (odds ratio, 4.8; 95% CI, 0.542-46.280), and LEEP (odds ratio, 4.0; 95% CI, 0.439-43.793) specimens, is associated with a statistically insignificant increased risk of LVSI in the hysterectomy specimen. CONCLUSION: Cervical biopsy and excision specimens lack sufficient negative predictive value for the detection of LVSI in the hysterectomy specimen. C1 [Bidus, Michael A.; Chernofsky, Mildred R.; Rose, G. Scott] Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Caffrey, Angela S.] Univ So Calif, Dept Obstet & Gynecol, Div Gynecol Oncol, Los Angeles, CA 90089 USA. [Amezcua, Charles A.] Univ So Calif, Dept Pathol, Los Angeles, CA 90089 USA. [Barner, Ross] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Seidman, Jeffrey] Washington Hosp Ctr, Dept Pathol, Washington, DC 20010 USA. RP Rose, GS (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, 6900 Georgia Ave, Washington, DC 20307 USA. EM scott.rose@na.amedd.army.mil NR 16 TC 0 Z9 0 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD AUG PY 2008 VL 199 IS 2 AR 151.e1 DI 10.1016/j.ajog.2008.02.017 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 331RY UT WOS:000258031500023 PM 18674657 ER PT J AU Cohen, SP Hurley, RW Buckenmaier, CC Kurihara, C Morlando, B Dragovich, A AF Cohen, Steven P. Hurley, Robert W. Buckenmaier, Chester C., III Kurihara, Connie Morlando, Benny Dragovich, Anthony TI Randomized placebo-controlled study evaluating lateral branch radiofrequency denervation for sacroiliac joint pain SO ANESTHESIOLOGY LA English DT Article; Proceedings Paper CT 15th Annual Meeting of the International-Spinal-Interventional-Society CY JUL 20, 2007 CL Baltimore, MD SP Int Spinal Intervent Soc ID LOW-BACK-PAIN; PERIARTICULAR CORTICOSTEROID TREATMENT; SERONEGATIVE SPONDYLARTHROPATHY; NEUROTOMY; EFFICACY; SPONDYLOARTHROPATHY; PREDICTORS; INJECTIONS; DIAGNOSIS; BLOCKS AB Background: Sacroiliac joint pain is a challenging condition accounting for approximately 20% of cases of chronic low back pain. Currently, there are no effective long-term treatment options for sacroiliac joint pain. Methods: A randomized placebo-controlled study was conducted in 28 patients with injection-diagnosed sacroiliac joint pain. Fourteen patients received L4-L5 primary dorsal ram! and S1-S3 lateral branch radiofrequency denervation using cooling-probe technology after a local anesthetic block, and 14 patients received the local anesthetic block followed by placebo denervation. Patients who did not respond to placebo injections crossed over and were treated with radiofrequency denervation using conventional technology. Results: One, 3, and 6 months after the procedure, 11 (79%), 9 (64%), and 8 (57%) radiofrequency-treated patients experienced pain relief of 50% or greater and significant functional improvement. In contrast, only 2 patients (14%) in the placebo group experienced significant improvement at their 1-month follow-up, and none experienced benefit 3 months after the procedure. in the crossover group (n = 11), 7 (64%), 6 (55%), and 4 (36%) experienced improvement 1, 3, and 6 months after the procedure. One year after treatment, only 2 patients (14%) in the treatment group continued to demonstrate persistent pain relief. Conclusions: These results provide preliminary evidence that L4 and L5 primary dorsal rami and S1-S3 lateral branch radiofrequency denervation may provide intermediate-term pain relief and functional benefit in selected patients with suspected sacroiliac joint pain. Larger studies are needed to confirm these results and to determine the optimal candidates and treatment parameters for this poorly understood disorder. C1 [Cohen, Steven P.; Hurley, Robert W.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care Med, Washington, DC USA. [Cohen, Steven P.; Buckenmaier, Chester C., III] Walter Reed Army Med Ctr, Washington, DC USA. [Buckenmaier, Chester C., III] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD USA. [Dragovich, Anthony] Pain Management Ctr, Ft Bragg, NC USA. RP Cohen, SP (reprint author), Johns Hopkins Pain Management Div, 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU NIMH NIH HHS [T32 MH075884-04, T32 MH075884, MH075884] NR 32 TC 84 Z9 89 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD AUG PY 2008 VL 109 IS 2 BP 279 EP 288 PG 10 WC Anesthesiology SC Anesthesiology GA 330KK UT WOS:000257939600016 PM 18648237 ER PT J AU Ressner, RA Griffith, ME Beckius, ML Pimentel, G Miller, RS Mende, K Fraser, SL Galloway, RL Hospenthal, DR Murray, CK AF Ressner, Roseanne A. Griffith, Matthew E. Beckius, Miriam L. Pimentel, Guillermo Miller, R. Scott Mende, Katrin Fraser, Susan L. Galloway, Renee L. Hospenthal, Duane R. Murray, Clinton K. TI Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID IN-VITRO SUSCEPTIBILITIES; HAMSTER MODEL; CONTROLLED-TRIAL; INTERROGANS; PENICILLIN; THERAPY; AGENTS; AZITHROMYCIN; AMOXICILLIN; DOXYCYCLINE AB Although antimicrobial therapy of leptospirosis has been studied in a few randomized controlled clinical studies, those studies were limited to specific regions of the world and few have characterized infecting strains. A broth microdilution technique for the assessment of antibiotic susceptibility has been developed at Brooke Army Medical Center. In the present study, we assessed the susceptibilities of 13 Leptospira isolates (including recent clinical isolates) from Egypt, Thailand, Nicaragua, and Hawaii to 13 antimicrobial agents. Ampicillin, cefepime, azithromycin, and clarithromycin were found to have MICs below the lower limit of detection (0.016 mu g/ml). Cefotaxime, ceftriaxone, imipenem-cilastatin, penicillin G, moxifloxacin, ciprofloxacin, and levofloxacin had MIC(90)s between 0.030 and 0.125 mu g/ml. Doxycycline and tetracycline had the highest MIC(90)s: 2 and 4 mu g/ml, respectively. Doxycycline and tetracycline were noted to have slightly higher MICs against isolates from Egypt than against strains from Thailand or Hawaii; otherwise, the susceptibility patterns were similar. There appears to be possible variability in susceptibility to some antimicrobial agents among strains, suggesting that more extensive testing to look for geographic variability should be pursued. C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Ft Sam Houston, TX 78234 USA. [Pimentel, Guillermo] USN, Med Res Unit 3, Cairo, Egypt. [Miller, R. Scott] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Mende, Katrin] Infect Dis Clin Res Program, Ft Sam Houston, TX USA. [Galloway, Renee L.] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Valle, Ruben/A-7512-2013; OI Pimentel, Guillermo/0000-0003-2464-1526 NR 25 TC 28 Z9 28 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2008 VL 52 IS 8 BP 2750 EP 2754 DI 10.1128/AAC.00044-08 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 336LR UT WOS:000258365800007 PM 18411316 ER PT J AU Moland, ES Craft, DW Hong, SG Kim, SY Hachmeister, L Sayed, SD Thomson, KS AF Moland, Ellen S. Craft, David W. Hong, Seong-geun Kim, Soo-young Hachmeister, Lucas Sayed, Shimon D. Thomson, Kenneth S. TI In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PSEUDOMONAS-AERUGINOSA; NEW-YORK; SUSCEPTIBILITY; MECHANISMS; EMERGENCE; PREVENTS; IMIPENEM; GAR-936 AB Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs. C1 [Thomson, Kenneth S.] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Omaha, NE 68178 USA. [Craft, David W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Thomson, KS (reprint author), Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, 2500 Calif Plaza, Omaha, NE 68178 USA. EM kstaac@creighton.edu NR 16 TC 17 Z9 25 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 2008 VL 52 IS 8 BP 2940 EP 2942 DI 10.1128/AAC.01581-07 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 336LR UT WOS:000258365800038 PM 18519722 ER PT J AU Nalca, A Hatkin, JM Garza, NL Nichols, DK Norris, SW Hruby, DE Jordan, R AF Nalca, Aysegul Hatkin, Josh M. Garza, Nicole L. Nichols, Donald K. Norris, Sarah W. Hruby, Dennis E. Jordan, Robert TI Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model SO ANTIVIRAL RESEARCH LA English DT Article DE orthopoxvirus; rabbitpox virus; aerosol; smallpox; rabbit; ST-246 ID ANTIPOXVIRUS COMPOUND ST-246; INFECTION; EFFICACY; POX; SMALLPOX; MICE AB Orthopoxviruses, such as variola and monkeypox viruses, can cause severe disease in humans when delivered by the aerosol route, and thus represent significant threats to both military and civilian populations. Currently, there are no antiviral therapies approved by the U.S. Food and Drug Administration (FDA) to treat smallpox or monkeypox infection. In this study, we showed that administration of the antiviral compound ST-246 to rabbits by oral gavage, once daily for 14 days beginning 1 h postexposure (p.e.), resulted in 100% survival in a lethal aerosolized rabbitpox model used as a surrogate for smallpox. Furthermore, efficacy of delayed treatment with ST-246 was evaluated by beginning treatment on days 1, 2, 3, and 4 p.e. Although a limited number of rabbits showed less severe signs of the rabbitpox disease from the day 1 and day 2 p.e. treatment groups, their illness resolved very quickly, and the survival rates for these group of rabbits were 88% and 100%, respectively. But when the treatment was started on days 3 or 4 p.e., survival was 67% and 33%, respectively. This work suggests that ST-246 is a very potent antiviral compound against aerosolized rabbitpox in rabbits and should be investigated for further development for all orthopoxvirus diseases. Published by Elsevier B.V. C1 [Nalca, Aysegul; Hatkin, Josh M.; Garza, Nicole L.] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. [Nichols, Donald K.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Norris, Sarah W.] USA, Med Res Inst Infect Dis, Res Support Div, Ft Detrick, MD 21702 USA. [Hruby, Dennis E.; Jordan, Robert] SIGA Technol Inc, Corvallis, OR USA. RP Nalca, A (reprint author), USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. EM aysegul.nalca@amedd.army.mil NR 15 TC 47 Z9 50 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD AUG PY 2008 VL 79 IS 2 BP 121 EP 127 DI 10.1016/j.antiviral.2008.03.005 PG 7 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 317FB UT WOS:000257004200006 PM 18479761 ER PT J AU Brooke, H Perkins, DL Setlow, B Setlow, P Bronk, BV Myrick, ML AF Brooke, Heather Perkins, David L. Setlow, Barbara Setlow, Peter Bronk, Burt V. Myrick, Michael L. TI Sampling and quantitative analysis of clean B-subtilis spores at sub-monolayer coverage by reflectance Fourier transform infrared microscopy using gold-coated filter substrates SO APPLIED SPECTROSCOPY LA English DT Article DE Fourier transform infrared microspectroscopy; FT-IR spectroscopy; mid-infrared spectroscopy; MIR spectroscopy; bacterial endospores; reflectance; linearity studies; absorption cross-section; scattering profile ID BACTERIAL ENDOSPORES; STATISTICAL-ANALYSIS; RAMAN-SPECTROSCOPY; BIOLOGICAL WEAPONS; IDENTIFICATION; BIOTERRORISM; EXTINCTION; SIMULANTS; ANTHRAX; THREAT AB A study was conducted to determine the concentration dependency of the mid-infrared (MIR) absorbance of bacterial spores. A range of concentrations of Bacillus subtilis endospores filtered across gold-coated filter membranes were analyzed by Fourier transform infrared (FT-IR) reflectance microscopy. Calibration curves were derived from the peak absorbances associated with Amide A, Amide 1, and Amide 11 vibrational frequencies by automatic baseline fitting to remove most of the scattering contribution. Linear relationships (R-2 >= 0.99) were observed between the concentrations of spores and the baseline-corrected peak absorbance for each frequency studied. Detection limits for our sampled area of 100 X 100 mu m(2) were determined to be 79, 39, and 184 spores (or 7.92 X 10(5), 3.92 X 10(5), and 1.84 X 10(6) spores/cm(2)) for the Amide A, Amide I, and Amide II peaks, respectively. Absorbance increased linearly above the scattering baseline with particle surface concentration up to 0.9 monolayer (ML) coverage, with the monolayer density calculated to be approximately 1.17 X 10(8) spores/cm(2). Scattering as a function of surface concentration, as estimated from extinction values at wavelengths exhibiting low absorbance, becomes nonlinear at a much lower surface concentration. The apparent scattering cross-section per spore decreased monotonically as concentrations increased toward 1.2 ML, while the absolute scattering decreased between 0.9 ML and 1.2 ML coverage. Calculations suggest that transverse spatial coherence effects are the origin of this nonlinearity, while the onset of nonlinearity in the baseline-corrected absorption is probably due to multiple scattering effects, which appear at a high surface concentration. Absorption cross-sections at peaks of the three bands were measured to be (2.15 +/- 0.05) X 10(-9), (1.48 +/- 0.03) X 10(-9), and (0.805 +/- 0.023) X 10(-9) cm(2), respectively. These values are smaller by a factor of 2-4 than expected from the literature. The origin of the reduced cross-section is hypothesized to be an electric field effect related to the surface selection rule. C1 [Brooke, Heather; Myrick, Michael L.] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [Perkins, David L.] Ometric Corp, Columbia, SC 29223 USA. [Setlow, Barbara; Setlow, Peter] Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT 06030 USA. [Bronk, Burt V.] USAF, Res Lab RHPC, Wright Patterson AFB, OH 45324 USA. [Bronk, Burt V.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21010 USA. RP Myrick, ML (reprint author), Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. EM myrick@sc.edu OI Myrick, Michael/0000-0002-6905-0925 FU Army Research Office [DAAD 190010557] FX The authors gratefully acknowledge support from the Army Research Office under Grant # DAAD 190010557. NR 31 TC 12 Z9 12 U1 0 U2 4 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD AUG PY 2008 VL 62 IS 8 BP 881 EP 888 PG 8 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 337EP UT WOS:000258418600008 PM 18702861 ER PT J AU James, WF Larson, CE AF James, William F. Larson, Catherine E. TI Phosphorus dynamics and loading in the turbid Minnesota River (USA): controls and recycling potential SO BIOGEOCHEMISTRY LA English DT Article DE equilibrium phosphorus concentration; phosphorus; redox-sensitive phosphorus; rivers; soluble phosphorus; suspended sediment ID EXTRACTABLE SOIL-PHOSPHORUS; LONG-TERM CHANGES; RUNOFF PHOSPHORUS; BIOAVAILABLE PHOSPHORUS; PARTICULATE PHOSPHORUS; MISSISSIPPI RIVER; STREAM SEDIMENTS; PHOSPHATE; NITROGEN; LAKE AB Phosphorus (P) dynamics in the agriculturally-dominated Minnesota River(USA) were examined in the lower 40 mile reach in relation to hydrology, loading sources, suspended sediment, and chlorophyll to identify potential biotic and abiotic controls over concentrations of soluble P and the recycling potential of particulate P during transport to the Upper Mississippi River. Within this reach, wastewater treatment plant (WWTP) contributions as soluble reactive P (SRP) were greatest during very low discharge and declined with increasing discharge and nonpoint source P loading. Concentrations of SRP declined during low discharge in conjunction with increases in chlorophyll, suggesting biotic transformation to particulate P via phytoplankton uptake. During higher discharge periods, SRP was constant at similar to 0.115 mg l(-1) and coincided with an independently measured equilibrium P concentration (EPC) for suspended sediment in the river, suggesting abiotic control over SRP via phosphate buffering. Particulate P (PP) accounted for 66% of the annual total P load. Redox-sensitive PP, estimated using extraction procedures, represented 43% of the PP. Recycling potential of this load via diffusive sediment P flux under anoxic conditions was conservatively estimated as similar to 17 mg m(-2) d(-1) using published regression equations. The reactive nature and high P recycling potential of suspended sediment loads in the Minnesota River has important consequences for eutrophication of the Upper Mississippi River. C1 [James, William F.] Engn Res & Dev Ctr, Eau Galle Aquat Ecol Lab, Spring Valley, WI 54767 USA. [Larson, Catherine E.] Metropolitan Council Environm Serv, St Paul, MN 55101 USA. RP James, WF (reprint author), Engn Res & Dev Ctr, Eau Galle Aquat Ecol Lab, W 500 Eau Galle Dam Rd, Spring Valley, WI 54767 USA. EM william.f.james@erdc.usace.army.mil; cathy.larson@metc.state.mn.us FU Metropolitan Council Environmental Services (MCES) of St. Paul, MN; US Army Engineer District, St. Paul (USAE St. Paul); Engineer Research and Development Center System-Wide Water Resources FX Metropolitan Council Environmental Services (MCES) of St. Paul, MN, and the US Army Engineer District, St. Paul (USAE St. Paul), are gratefully acknowledged for funding this research. We thank H. Eakin and L. Pommier of the Engineer Research and Development Center (ERDC) Eau Galle Aquatic Ecology Laboratory, K. Jensen, S. Schellhaass, and personnel of MCES for sampling, chemical analyses, and database compilation, A. Buesing (USAE St. Paul) and D. Smith (ERDC) for modeling travel time, and anonymous reviewers for helpful comments that improved this manuscript. Additional funding was provided by the Engineer Research and Development Center System- Wide Water Resources Program. Permission to publish this information was granted by the Chief of Engineers. NR 81 TC 11 Z9 12 U1 5 U2 19 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0168-2563 EI 1573-515X J9 BIOGEOCHEMISTRY JI Biogeochemistry PD AUG PY 2008 VL 90 IS 1 BP 75 EP 92 DI 10.1007/s10533-008-9232-5 PG 18 WC Environmental Sciences; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA 348YO UT WOS:000259246200006 ER PT J AU Nablo, BJ Halverson, KM Robertson, JWF Nguyen, TL Panchal, RG Gussio, R Bavari, S Krasilnikov, OV Kasianowicz, JJ AF Nablo, Brian J. Halverson, Kelly M. Robertson, Joseph W. F. Nguyen, Tam L. Panchal, Rekha G. Gussio, Rick Bavari, Sina Krasilnikov, Oleg V. Kasianowicz, John J. TI Sizing the Bacillus anthracis PA(63) channel with nonelectrolyte poly(ethylene glycols) SO BIOPHYSICAL JOURNAL LA English DT Article ID SYMMETRICAL TETRAALKYLAMMONIUM IONS; PHOSPHOLIPID-BILAYER MEMBRANES; TOXIN PROTECTIVE ANTIGEN; PLANAR LIPID-BILAYERS; PROTEIN TRANSLOCATION; CRYSTAL-STRUCTURE; ANION CHANNEL; PORE RADIUS; CONDUCTIVITY; CONDUCTANCE AB Nonelectrolyte polymers of poly(ethylene glycol) (PEG) were used to estimate the diameter of the ion channel formed by the Bacillus anthracis protective antigen 63 (PA(63)). Based on the ability of different molecular weight PEGs to partition into the pore and reduce channel conductance, the pore appears to be narrower than the one formed by Staphylococcus aureus a-hemolysin. Numerical integration of the PEG sample mass spectra and the channel conductance data were used to refine the estimate of the pore's PEG molecular mass cutoff (similar to 1400 g/mol). The results suggest that the limiting diameter of the PA(63) pore is < 2 nm, which is consistent with an all-atom model of the PA(63) channel and previous experiments using large ions. C1 [Nablo, Brian J.; Robertson, Joseph W. F.; Kasianowicz, John J.] NIST, Div Semicond Elect, Elect & Elect Lab, Gaithersburg, MD 20899 USA. [Halverson, Kelly M.] USA, Ctr Environm Hlth Res, Frederick, MD USA. [Nguyen, Tam L.; Panchal, Rekha G.; Gussio, Rick] NCI, Target Struct Based Drug Discovery Grp, SAIC Frederick, Frederick, MD 21701 USA. [Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Krasilnikov, Oleg V.] Univ Fed Pernambuco, Lab Membrane Biophys, Dept Biophys & Radiobiol, Recife, PE, Brazil. RP Kasianowicz, JJ (reprint author), NIST, Div Semicond Elect, Elect & Elect Engn Lab, Gaithersburg, MD 20899 USA. EM john.kasianowicz@nist.gov FU NCI NIH HHS [N01-CO-12400, N01CO12400] NR 53 TC 23 Z9 23 U1 1 U2 5 PU BIOPHYSICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD AUG 1 PY 2008 VL 95 IS 3 BP 1157 EP 1164 DI 10.1529/biophysj.107.121715 PG 8 WC Biophysics SC Biophysics GA 327HC UT WOS:000257719200017 PM 18645196 ER PT J AU Li, QG Si, YZ Smith, KS Zeng, Q Weina, PJ AF Li, Qigui Si, Yuanzheng Smith, Kirsten S. Zeng, Qiang Weina, Peter J. TI Embryotoxicity of artesunate in animal species related to drug tissue distribution and toxicokinetic profiles SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY LA English DT Article DE artesunate; dihydroartemisinin; embryo toxicity; toxicokinetics; tissue distribution; pregnant; non-pregnant; rats ID UNCOMPLICATED FALCIPARUM-MALARIA; PREGNANT-WOMEN; IN-VITRO; DIHYDROARTEMISININ DHA; RAT EMBRYOS; PHARMACOKINETICS; ARTEMISININ; ARTEMETHER; PROGUANIL; TOXICITY AB BACKGROUND: Injectable artesunate (AS) can cause fetal death and teratogenic effects in animals at levels below the human therapeutic dose. Similar toxicity has also been found for oral artemisinins in various animal species, but has not been found in humans. METHODS: Studies on tissue distribution (5 mg/kg) and toxicokinetics TK, 30 mg/kg x 3) were conducted in pregnant (GD11-13) and non-pregnant rats. RESULTS: TK, profiles of AS showed that the two groups of rats were similar after a single AS dose but were significantly different after multiple doses. Following a daily dose for 3 days, no change in AS concentration was found in the pregnant animals, but a significant concentration decline was seen in the non-pregnant rats on day 3. In addition, a higher conversion rate of AS to diliydroartemisinin (DHA) was detected in the pregnant rats after either single or multiple doses compared to non-pregnant controls. The ratios of AUC(DHA)/AUC(AS) were 0.99-1.02 for the pregnant rats and 0.42-0.48 for non-pregnant animals, resulting in a total AUC(DHA) (D1-3) that was about 3.7-fold higher in pregnant rats 05,049 ng.h/ml) than in non-pregnant rats (4,015ng-h/ml). Furthermore, the tissue/blood partition coefficients demonstrated that the level of radiolabeled AS that was distributed into uteri-is, placenta, and ovary was 2-4-fold higher than in blood. CONCLUSIONS: TK data showed that unchanged AS and DHA in the blood of pregnant rats were 1.53- and 3.74-fold, respectively, higher than those of non-pregnant animals, which all likely relate to the severe embryotoxicity of AS, even with a low-dosage regimen in pregnant animals. C1 [Li, Qigui; Si, Yuanzheng; Smith, Kirsten S.; Zeng, Qiang; Weina, Peter J.] Walter Reed Army Inst Res, Dept Pharmacol, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Li, QG (reprint author), Walter Reed Army Inst Res, Dept Pharmacol, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM qigui.li@amedd.army.mil RI Weina, Peter/A-2120-2011 FU United States Army Research and Material Command FX This study was supported by the United States Army Research and Material Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the Department of the Army or the Department of Defense. NR 45 TC 11 Z9 11 U1 0 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1542-9733 J9 BIRTH DEFECTS RES B JI Birth Defects Res. Part B-Dev. Reprod. Toxicol. PD AUG PY 2008 VL 83 IS 4 BP 435 EP 445 DI 10.1002/bdrh.20164 PG 11 WC Oncology; Genetics & Heredity; Toxicology SC Oncology; Genetics & Heredity; Toxicology GA 344NT UT WOS:000258935300004 PM 18636509 ER PT J AU Buckenmaier, CC Bleckner, LL AF Buckenmaier, C. C., III Bleckner, L. L. TI Continuous peripheral nerve blocks and anticoagulation SO BRITISH JOURNAL OF ANAESTHESIA LA English DT Editorial Material ID MOLECULAR-WEIGHT HEPARIN; LUMBAR PLEXUS BLOCK; REGIONAL-ANESTHESIA; RETROPERITONEAL HEMATOMA; NEURAXIAL ANESTHESIA; ORTHOPEDIC-SURGERY; PATIENT; COMPLICATIONS C1 [Buckenmaier, C. C., III; Bleckner, L. L.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Buckenmaier, CC (reprint author), Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM chester.buckenmaier@amedd.army.mil NR 14 TC 2 Z9 2 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0007-0912 J9 BRIT J ANAESTH JI Br. J. Anaesth. PD AUG PY 2008 VL 101 IS 2 BP 139 EP 140 DI 10.1093/bja/aen192 PG 2 WC Anesthesiology SC Anesthesiology GA 325GE UT WOS:000257576200002 PM 18614597 ER PT J AU Ritenour, AE Morton, MJ McManus, JG Barillo, DJ Cancio, LC AF Ritenour, Amber E. Morton, Melinda J. McManus, John G. Barillo, David J. Cancio, Leopoldo C. TI Lightning injury: a review SO BURNS LA English DT Review DE lightning; burns ID UNITED-STATES; BIOPHYSICAL INJURY; STRIKE; MANIFESTATIONS; FATALITIES; DEATHS; ENCEPHALOPATHY; MECHANISMS; SITUATIONS; MORBIDITY AB Lightning is an uncommon but potentially devastating cause of injury in patients presenting to burn centers. These injuries feature unusual symptoms, high mortality, and significant long-term morbidity. This paper will review the epidemiology, physics, clinical presentation, management principles, and prevention of lightning injuries. Published by Elsevier Ltd and ISBI. C1 [Ritenour, Amber E.; Morton, Melinda J.; McManus, John G.; Barillo, David J.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Ritenour, Amber E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM lee.cancio@us.army.mil NR 91 TC 30 Z9 32 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD AUG PY 2008 VL 34 IS 5 BP 585 EP 594 DI 10.1016/j.burns.2007.11.006 PG 10 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 324RL UT WOS:000257535600001 PM 18395987 ER PT J AU Requles, JA Glasser, JS Wolf, SE Hospenthal, DR Murray, CK AF Requles, Jason A. Glasser, Jessie S. Wolf, Steven E. Hospenthal, Duane R. Murray, Clinton K. TI Endocarditis in burn patients: Clinical and diagnostic considerations SO BURNS LA English DT Article DE endocarditis; duke criteria; burn; Pseudomonas aeruginosa; echocardiography; Staphylococcus aureus; Enterococcus faecium ID STAPHYLOCOCCUS-AUREUS BACTEREMIA; ACUTE BACTERIAL-ENDOCARDITIS; PULMONARY-ARTERY CATHETER; INFECTIVE ENDOCARDITIS; VALVE ENDOCARDITIS; THERMAL-INJURY; DUKE CRITERIA; ECHOCARDIOGRAPHY; EPIDEMIOLOGY; PREDICTORS AB Background: Burned patients are at high risk for invasive procedures, bacteremia, and other infectious complications. Previous publications describe high incidence, delayed diagnosis, and high mortality for endocarditis in burned patients, but do not address use of contemporary diagnostic criteria. Further analysis of the clinical presentation and diagnosis may aid in the earlier recognition and decreased mortality of endocarditis in burned patients. Methods: At a 40 bed burn center, during the period from 1 January 2003 to 1 August 2006, blood culture, electronic inpatient, echocardiographic, and autopsy records were reviewed for cases of endocarditis and persistent bacteremia (blood culture positivity for the same organism separated by 24 h). In addition, we reviewed cases of burn-related bacterial endocarditis published in the English language. We compared the clinical and diagnostic aspects of our identified cases with those in the published literature. Results: There were 90 episodes of persistent bacteremia or fungemia in 56 of 1250 patients admitted during the study period. Echocardiography was performed on 19, identifying 4 cases of endocarditis. One additional case of endocarditis was identified post-mortem. Time until echocardiography ranged from 6 to 176 days after onset of bacteremia. Case patient age ranged from 31 to 64 years, and total burn surface area ranged from 34 to 80%. Endocarditis occurred in 0.4% of burn unit admissions and in 8.9% of these patients with persistent bacteremia. Sites involved included the mitral valve (3), tricuspid valve (2), aortic valve (1), and pulmonic valve (1). Pathogens included Staphylococcus aureus, Pseudomonas aeruginosa, and one case of Enterococcus faecium. Diagnostic clues were minimal. Case mortality was 100%. A literature review revealed 17 publications describing confirmed bacterial endocarditis in burned patients. These cases revealed a predilection for infection by S. aureus and P. aeruginosa, a relative paucity of diagnostic clues prior to death, and a trend towards antemortem diagnosis and increased survival with use of diagnostic echocardiography. Conclusions: The incidence and mortality of endocarditis in burned patients remain high. Clinical clues for endocarditis in this cohort are minimal and diagnosis may be delayed. For burned patients with persistent bacteremia, especially S. aureus or P. aeruginosa of unknown source, the diagnosis of endocarditis should be entertained and early echocardiography considered. Published by Elsevier Ltd and ISBI. C1 [Requles, Jason A.; Glasser, Jessie S.; Hospenthal, Duane R.; Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Wolf, Steven E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 46 TC 3 Z9 6 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD AUG PY 2008 VL 34 IS 5 BP 610 EP 616 DI 10.1016/j.burns.2007.08.002 PG 7 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 324RL UT WOS:000257535600004 PM 18029099 ER PT J AU Schindler, BJ Buettner, LC Levan, MD AF Schindler, Bryan J. Buettner, Leonard C. LeVan, M. Douglas TI Transition to Henry's law in ultra-low concentration adsorption equilibrium for n-pentane on BPL activated carbon SO CARBON LA English DT Article ID VOLATILE ORGANIC-COMPOUNDS; GAS-ADSORPTION; WATER-VAPOR; HYDROCARBONS; COADSORPTION; PRESSURES; KINETICS; BENZENE; ALKANES; STREAMS AB Experimental data for n-pentane adsorbed on BPL activated carbon in a nitrogen environment are reported at ultra-low concentrations into the Henry's law region. We introduce two methods to prepare pre-equilibrated samples at known loadings. The samples were analyzed by a purge and trap method. Adsorption data were measured at loadings from 1.0 to 0.0001 mol kg(-1) and pressures of 6 to 5 x 10(-10) kPa. The transition into the Henry's law region occurs over a range of loadings near 0.01 mol kg(-1) for all temperatures. The data are compared with the DR, Langmuir, and Toth equations. We discuss how the three equations transition into the Henry's law region, and how well they describe the data. Since the DR equation does not have a proper Henry's law region, we show where this equation no longer applies. The Toth equation describes the data better than the Langmuir equation. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Schindler, Bryan J.; LeVan, M. Douglas] Vanderbilt Univ, Dept Chem Engn, Nashville, TN 37235 USA. [Buettner, Leonard C.] USA, Edgewood Chem Biol Ctr, AMSRD ECB RT, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Levan, MD (reprint author), Vanderbilt Univ, Dept Chem Engn, VU Stn B 351604,2301 Vanderbilt Pl, Nashville, TN 37235 USA. EM m.douglas.levan@vanderbilt.edu RI Schindler, Bryan/I-1529-2013 OI Schindler, Bryan/0000-0003-3127-2722 FU US Army ECBC FX We are grateful for the US Army ECBC for the support of this research. Helpful discussions with John J. Mahle, Christopher Karwacki, Tara Sewell, and David E. Tevault are appreciated. NR 33 TC 12 Z9 12 U1 2 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD AUG PY 2008 VL 46 IS 10 BP 1285 EP 1293 DI 10.1016/j.carbon.2008.05.001 PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 345HQ UT WOS:000258987500003 ER PT J AU Atikovic, E Suidan, MT Maloney, SW AF Atikovic, Emina Suidan, Makram T. Maloney, Stephen W. TI Anaerobic treatment of army ammunition production wastewater containing perchlorate and RDX SO CHEMOSPHERE LA English DT Article DE perchlorate; RDX; anaerobic; fluidized bed ID FLUIDIZED-BED REACTOR; 2,4,6-TRINITROTOLUENE; BIOTRANSFORMATION AB Perchlorate is an oxidizer that has been routinely used in solid rocket motors by the Department of Defense and National Aeronautics and Space Administration. Royal Demolition Explosive (RDX) is a major component of military high explosives and is used in a wide variety of munitions. Perchlorate bearing wastewater typically results from production of solid rocket motors, while RDX is transferred to Army industrial wastewaters during load, assemble and pack operations for new munitions, and hot water or steam washout for disposal and deactivation of old munitions (commonly referred to as demilitarization, or simply demil). Biological degradation in Anaerobic Fluidized Bed Reactors (AFBR), has been shown to be an effective method for the removal of both perchlorate and RDX in contaminated wastewater. The focus of this study was to determine the effectiveness or removal of perchlorate and RDX, individually and when co-mingled, using ethanol as an electron donor under steady state conditions. Three AFBRs were used to assess the effectiveness of this process in treating the wastewater. The performance of the bioreactors was monitored relative to perchlorate, RDX, and chemical oxygen demand removal effectiveness. The experimental results demonstrated that the biodegradation of perchlorate and RDX was more effective in bioreactors receiving the single contaminant than in the bioreactor where both contaminants were fed. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Atikovic, Emina; Suidan, Makram T.] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA. [Maloney, Stephen W.] USA, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Suidan, MT (reprint author), Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA. EM atikovic@gmail.com; makram.suidan@uc.edu; s-maloney@cecer.army.mil FU Engineering Research and Development Center - Construction Engineering Research Laboratory FX This research was supported by Engineering Research and Development Center - Construction Engineering Research Laboratory. They were also providers of the RDX In addition, we would like to acknowledge joint Munitions Command - Rock Island Arsenal. NR 16 TC 18 Z9 22 U1 2 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD AUG PY 2008 VL 72 IS 11 BP 1643 EP 1648 DI 10.1016/j.chemosphere.2008.05.043 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 344BV UT WOS:000258901300003 PM 18586300 ER PT J AU Collen, JF Jackson, JL Shorr, AF Moores, LK AF Collen, Jacob F. Jackson, Jeffrey L. Shorr, Andrew F. Moores, Lisa K. TI Prevention of venous thromboembolism in neurosurgery - A metaanalysis SO CHEST LA English DT Article DE hemorrhage; intracranial hemorrhages; neurosurgery; thromboembolism; thrombosis ID DEEP-VEIN THROMBOSIS; MOLECULAR-WEIGHT HEPARIN; INTERMITTENT PNEUMATIC COMPRESSION; LOW-DOSE HEPARIN; RANDOMIZED TRIAL; CLINICAL-TRIALS; SPINAL SURGERY; STOCKING PROPHYLAXIS; PULMONARY-EMBOLISM; PUBLICATION BIAS AB Background: Venous thromboembolism (VTE) is an important complication of neurosurgery. Current guidelines recommend pharmacologic prophylaxis in this setting with either unfractionated heparin or low-molecular-weight heparin (LMWH). We conducted a systematic review asking, "Among patients undergoing neurosurgical procedures, how safe and effective is the prophylactic use of heparin and mechanical devices?" Methods: We searched the medical literature to identify prospective trials reporting on VTE prevention (either mechanical or pharmacologic). The rates of VTE and bleeding were our primary end points and were pooled using a random-effects model. Results: We identified 30 studies reporting on 7,779 patients. There were IS randomized controlled trials and 12 cohort studies. The results of pooled relative risks (RRs) showed LMWH and intermittent compression devices (ICDs) to be effective in reducing the rate of deep vein thrombosis (LMWH: RR, 0.60; 95% confidence interval [CI], 0.44 to 0.81; ICD: RR, 0.41; 95% CI, 0.21 to 0.78). Similar results were seen when pooled rates from all 30 trials were analyzed. in head-to-head trials, there was no statistical difference in the rate of intracranial hemorrhage (ICH) between therapy with LMWH and nonpharmacologic methods (RR, 1.97; 95% CI, 0.64 to 6.09). The pooled rates of ICH and minor bleeding were generally higher with heparin therapy than,with non-heparin-based prophylactic modalities. Conclusions: In a mixed neurosurgical population, LMWH and ICDs are both effective in the prevention of VTE. Sensitivity analyses have suggested that isolated high-risk groups, such as those with patients undergoing craniotomy for neoplasm, may benefit from a combination of prophylactic methods, suggesting the need for a more individualized approach to these patients. C1 [Collen, Jacob F.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Jackson, Jeffrey L.; Moores, Lisa K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Shorr, Andrew F.] Washington Hosp Ctr, Dept Pulm Med, Washington, DC 20010 USA. RP Collen, JF (reprint author), 1672 N 21st St,Apartment 7, Arlington, VA 22209 USA. EM Jcollen2002@hotmail.com NR 51 TC 61 Z9 64 U1 1 U2 4 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD AUG PY 2008 VL 134 IS 2 BP 237 EP 249 DI 10.1378/chest.08-0023 PG 13 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 338FU UT WOS:000258492500007 PM 18641095 ER PT J AU Lapa, JA Sincock, SA Ananthakrishnan, M Porter, CK Cassels, FJ Brinkley, C Hall, ER van Hamont, J Gramling, JD Carpenter, CM Baqar, S Tribble, DR AF Lapa, Joyce A. Sincock, Stephanie A. Ananthakrishnan, Madhumita Porter, Chad K. Cassels, Frederick J. Brinkley, Carl Hall, Eric R. van Hamont, John Gramling, Joseph D. Carpenter, Colleen M. Baqar, S. Tribble, David R. TI Randomized clinical trial assessing the safety and immunogenicity of oral microencapsulated enterotoxigenic Escherichia coli surface antigen 6 with or without heat-labile enterotoxin with mutation R192G SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID COLONIZATION FACTOR ANTIGENS; UNITED-STATES-NAVY; HELICOBACTER-PYLORI; DIARRHEAL DISEASE; ANTIBODY-RESPONSES; TRAVELERS DIARRHEA; SECRETING CELLS; SUBUNIT VACCINE; FACTOR CS6; IMMUNIZATION AB An oral, microencapsulated anti-colonization factor 6 antigen (meCS6) vaccine, with or without heat-labile enterotoxin with mutation R192G (LT(R192G)) (mucosal adjuvant), against enterotoxigenic Escherichia coli (ETEC) was evaluated for regimen and adjuvant effects on safety and immunogenicity. Sixty subjects were enrolled into a three-dose, 2-week interval or four-dose, 2-day interval regimen. Each regimen was randomized into two equal groups of meCS6 alone (1 mg) or meCS6 with adjuvant (2 mu g of LT(R192G)). The vaccine was well tolerated and no serious adverse events were reported. Serologic response to CS6 was low in all regimens (0 to 27%). CS6-immunogloublin A (IgA) antibody-secreting cell (ASC) responses ranged from 36 to 86%, with the highest level in the three-dose adjuvanted regimen; however, the magnitude was low. As expected, serologic and ASC LT responses were limited to adjuvanted regimens, with the exception of fecal IgA, which appeared to be nonspecific to LT administration. Further modifications to the delivery strategy and CS6 and adjuvant dose optimization will be needed before conducting further clinical trials with this epidemiologically important class of ETEC. C1 [Lapa, Joyce A.; Sincock, Stephanie A.; Porter, Chad K.; Hall, Eric R.; Carpenter, Colleen M.; Baqar, S.; Tribble, David R.] USN, Med Res Ctr, Silver Spring, MD 20910 USA. [Ananthakrishnan, Madhumita; Cassels, Frederick J.; Brinkley, Carl; van Hamont, John] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Gramling, Joseph D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Lapa, JA (reprint author), USN, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM joyce.lapa@med.navy.mil RI Porter, Chad/A-8026-2011 FU Military Infectious Disease Research Program; NMRC [A0055] FX The views expressed in this article are those of the authors and do not necessarily reflect the official policy of the Department of the Navy, Department of Defense, or the U. S. Government.; This work was supported and funded by the Military Infectious Disease Research Program, NMRC Work Unit Number A0055. The study protocol was approved by the Naval Medical Research Center Institutional Review Board in compliance with all applicable federal regulations governing the protection of human subjects.; J.A.L. is a military service member. This work was prepared as part of her official duties. NR 48 TC 17 Z9 20 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD AUG PY 2008 VL 15 IS 8 BP 1222 EP 1228 DI 10.1128/CVI.00491-07 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 340TF UT WOS:000258667200012 PM 18579693 ER PT J AU Hu, Y Dobi, A Sreenath, T Cook, C Tadase, AY Ravindranath, L Cullen, J Furusato, B Chen, Y Thangapazham, RL Mohamed, A Sun, C Sesterhenn, IA McLeod, DG Petrovics, G Srivastava, S AF Hu, Ying Dobi, Albert Sreenath, Tacluru Cook, Christopher Tadase, Atekelt Y. Ravindranath, Lakshmi Cullen, Jennifer Furusato, Bungo Chen, Yongmei Thangapazham, Rajesh L. Mohamed, Ahmed Sun, Chen Sesterhenn, Isabell A. McLeod, David G. Petrovics, Gyorgy Srivastava, Shiv TI Delineation of TMPRSS2-ERG splice variants in prostate cancer SO CLINICAL CANCER RESEARCH LA English DT Article ID ETS TRANSCRIPTION FACTORS; FUSION TRANSCRIPTS; CELL-GROWTH; GENE; EXPRESSION; FREQUENCY; TISSUES AB Purpose: The expression of the ETS-related gene (ERG) is low or undetectable in benign prostate epithelial cells. High prevalence of ERG overexpression in prostate cancer cells due to TMPRSS2-ERG fusions suggest for causal roles of ERG protein in the neoplastic process. TMPRSS2-ERG fusion junctions have been extensively studied in prostate cancer. However, virtually nothing is known about the nature of full-length transcripts and encoded proteins. This study focuses on qualitative and quantitative features of full-length TMPRSS2-ERG transcripts in prostate cancer. Experimental Design: Full-length TMPRSS2-ERG transcripts were cloned and sequenced from a cDNA library generated from pooled RNA of six TMPRSS2-ERG fusion - positive prostate tumors. The encoded ERG proteins were analyzed in HEK293 cells. Copy numbers of TMPRSS2-ERG splice variants were determined by quantitative reverse transcription-PCR in laser capture microdissected prostate cancer cells. Results: Two types of TMPRSS2-ERG cDNAs were identified: type I, which encodes full-length prototypical ERG protein (ERG1, ERG2, ERG3), and type II, encoding truncated ERG proteins lacking the ETS domain (ERG8 and a new variant, TEPC). In microdissected prostate tumor cells from 122 patients, relative abundance of these variants was in the following order: ERG8 > TEPC > ERG 3 > ERG1/2 with combined overexpression rate of 62.3% in prostate cancer. Increased ratio of type I over type II splice forms showed a trend of correlation with less favorable pathology and outcome. Conclusions: Qualitative and quantitative features of specific ERG splice variants defined here promise to enhance the utility of ERG as a biomarker and therapeutic target in prostate cancer. C1 [Hu, Ying; Dobi, Albert; Sreenath, Tacluru; Cook, Christopher; Tadase, Atekelt Y.; Ravindranath, Lakshmi; Cullen, Jennifer; Furusato, Bungo; Chen, Yongmei; Thangapazham, Rajesh L.; Mohamed, Ahmed; Sun, Chen; McLeod, David G.; Petrovics, Gyorgy; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. [Furusato, Bungo; Sesterhenn, Isabell A.] Walter Reed Army Med Ctr, Armed Forces Inst Pathol, Dept Genitourinary Med, Washington, DC 20307 USA. [McLeod, David G.] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. [Hu, Ying; McLeod, David G.; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. EM gpetrovics@cpdr.org; ssrivastava@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 FU NCI NIH HHS [R01 CA106653]; NIDDK NIH HHS [R01 DK065977] NR 23 TC 41 Z9 43 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD AUG 1 PY 2008 VL 14 IS 15 BP 4719 EP 4725 DI 10.1158/1078-0432.CCR-08-0531 PG 7 WC Oncology SC Oncology GA 334JD UT WOS:000258217200008 PM 18676740 ER PT J AU Harrison, SA AF Harrison, Stephen A. TI Insulin resistance among patients with chronic hepatitis C: Etiology and impact on treatment SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article ID PEGINTERFERON PLUS RIBAVIRIN; TYPE-2 DIABETES-MELLITUS; BETA-CELL FUNCTION; SUSTAINED VIROLOGICAL RESPONSE; NECROSIS-FACTOR RECEPTORS; CYTOKINE SIGNALING SOCS; FATTY LIVER-DISEASE; VIRUS-INFECTION; ANTIVIRAL THERAPY; TNF-ALPHA AB Insulin resistance is extremely common and frequently is associated with comorbid conditions such as cardiovascular disease, hypertension, obesity, infertility, and neurodegeneration. In addition, insulin resistance is the driving force for type 2 diabetes mellitus. Interestingly, co-existence of insulin resistance and chronic hepatitis C occurs more often than predicted by chance, with recent estimates indicating that 30% to 70% of patients with chronic hepatitis C display some evidence of insulin resistance. Recent research revealed several molecules, including tumor necrosis factor a, suppressor of cytokine signaling I and 3 proteins, insulin-receptor substrates 1 and 2, and other adipocytokines, potentially are involved in the development of insulin resistance in patients with chronic hepatitis C. Unfortunately, baseline insulin resistance has a negative impact on treatment outcomes in patients with chronic hepatitis C. However, successfully managing insulin resistance or diabetes mellitus in these patients may improve patients' likelihoods of successful outcomes with antiviral therapy. Likewise, eradication of hepatitis C virus in patients with insulin resistance or diabetes mellitus appears to improve glucose metabolism. Although adjunctive therapies such as insulin sensitizers and weight loss often are recommended, their ability to improve antiviral treatment response in patients with chronic hepatitis C is unproven. Studies are under way to determine whether improving insulin sensitivity results in better outcomes in patients receiving pegylated interferon alfa plus ribavirin therapy for chronic hepatitis C. C1 Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Div Gastroenterol & Hepatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.Harrison@AMEDD.ARMY.MIL NR 98 TC 35 Z9 37 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD AUG PY 2008 VL 6 IS 8 BP 864 EP 876 DI 10.1016/j.cgh.2008.03.024 PG 13 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 335LQ UT WOS:000258292500009 PM 18585970 ER PT J AU McPherson, JC Runner, RR Shapiro, B Walsh, DS Stephens-DeValle, J Buxton, TB AF McPherson, James C., III Runner, Royce R. Shapiro, Brian Walsh, Douglas S. Stephens-DeValle, Julie Buxton, Thomas B. TI An acute osteomyelitis model in traumatized rat tibiae involving sand as a foreign body, thermal injury, and bimicrobial contamination SO COMPARATIVE MEDICINE LA English DT Article ID STAPHYLOCOCCUS-AUREUS OSTEOMYELITIS; ACUTE HEMATOGENOUS OSTEOMYELITIS; I COLLAGEN; BONE WAX; BINDING; INTERNALIZATION; CLASSIFICATION; FIBRONECTIN; OSTEOBLASTS; STRAINS AB The multfactorial nature of bone injuries in modern warfare and emergency trauma patients warrants enhancement of existing models. To develop a more appropriate model, rat tibiae (n = 195) were mechanically injured, divided into 2 groups (with or without thermal injury), and contaminated with a range of Staphylococcus aureus (Cowan 1) inocula. In some experiments, S. aureus inocula also contained Escherichia coli or foreign bodies (sand or soil). The primary outcome measure was the amount of S. aureus remaining in the tibia (tibial bacterial load) 24 h after contamination, reported as log(10) cfu/g bone. S. aureus showed ID50 and ID95 values of 72 and 977 cfu, respectively. Values were lower than seen previously by using S. aureus strain SMH. S. aureus tibial bacterial loads were higher in tibiae with mechanical and thermal injury (log(10) 4.15 +/- 0.27 cfu/g) versus mechanical injury alone (log(10) 3.1 +/- 0.47 cfu/g, P = 0.028). The addition of E. coli to the S. aureus inoculum had no effect on tibia] bacterial loads (S. aureus only, log(10) 4.24 +/- 0.92 cfu/g; S. aureus + E. coli, log(10) 4.1 +/- 1.0 cfu/g, P = 0.74). Sand, added as a foreign body, increased tibial bacterial load. Combined mechanical and thermal trauma of the tibia is associated with increased S. aureus tibial bacterial loads, increasing the risk of acute osteomyelitis. Understanding the interplay of mechanical and thermal injuries, bimicrobial contamination, and foreign bodies may improve our understanding of traumatic bone injuries and the pathogenesis of osteomyelitis. C1 [McPherson, James C., III; Stephens-DeValle, Julie] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. [Runner, Royce R.; Shapiro, Brian; Buxton, Thomas B.] Geneva Fdn, Lakewood, CO USA. [Shapiro, Brian] Med Coll Georgia, Augusta, GA 30912 USA. [Walsh, Douglas S.] USA, Med Res Unit Kenya, Kisumu, Kenya. RP McPherson, JC (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. EM james.mcpherson@amedd.army.mil RI Stephens-Devalle, Julie/B-7890-2011; OI Stephens-DeValle, Julie/0000-0002-3327-1849 FU Department of the Army [W81XWHM-06-2-0013] FX This research was funded by the Department of the Army, award number W81XWHM-06-2-0013. The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD, 21702-5014, is the awarding and administering acquisition office. The content of this information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.; The study was approved by the Institutional Animal Care and Use Committee at the Dwight David Eisenhower Army Medical Center (IACUC approval number 05-65A) and was conducted in compliance with the Animal Welfare Act and other federal and US Department of Defense regulations relating to animal experiments. The Department of Clinical Investigation is all AAALAC-accredited program. The study adhered to all principles stated in the Guide for the Cart and Use of Laboratory Animals, National Research Council Publication (1996).; The authors thank Malcolm J. Kling and Mr. Eugene Cauley for veterinary assistance. These data were presented in part at the 10th Annual Force Health Protection Conference, Louisville, KY, 2007 August 4-10. NR 33 TC 5 Z9 5 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD AUG PY 2008 VL 58 IS 4 BP 369 EP 374 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 344PN UT WOS:000258939900006 PM 18724779 ER PT J AU Butler, LK Hayden, TJ Romero, LM AF Butler, Luke K. Hayden, Timothy J. Romero, L. Michael TI PREBASIC MOLT OF BLACK-CAPPED AND WHITE-EYED VIREOS: EFFECTS OF BREEDING SITE AND THE EL NINO-SOUTHERN OSCILLATION SO CONDOR LA English DT Article DE El Nino; life history; migration; molt; Molothrus ater; Vireo atricapilla; Vireo griseus ID CURRENT REPRODUCTIVE EFFORT; DELAYED PLUMAGE MATURATION; CROWNED SPARROWS; LIFE-HISTORY; POSTNUPTIAL MOLT; HABITAT QUALITY; FEATHER GROWTH; POPULATION; MIGRATION; DURATION AB Ecological factors on the breeding grounds are expected to have a relatively large effect on the timing of molt in migratory birds breeding at middle latitudes (e.g., southern North America), because constraints on the time available to molt are probably weak. We investigated the timing of prebasic molt in adults of two migratory passerines, the endangered Black-capped Vireo (Vireo atricapilla) and the common White-eyed Vireo (V griseus), on their breeding grounds in Texas. We compared the onset and rate of molt between sites differing in habitat and between years differing greatly in precipitation due to the El Nino-Southern Oscillation (ENSO). Black-capped Vircos began molting 13 days later (8 July) and completed molt 12 days faster (50 days) in low quality, clumped habitat than in more typical, contiguous shrubby habitat (62-day molt starting 25 June). Long-term estimates of onset and duration of molt based on study skins were intermediate. White-eyed Vireos in the site with clumped habitat also started molting significantly later (13 July), but did not molt significantly faster (56 days), than those in the shrubby site (63-day molt starting 2 July). Both species started molting significantly later in the wet La Nina year than in the year with dry El Nino conditions. Body condition did not differ between sites or years. Our molt duration estimates of approximate to 55 days for Black-capped Vireos and approximate to 60 days for White-eyed Vireos suggest weak time constraints on molt in these populations. This study highlights the sensitivity of molt dynamics to events and conditions during the preceding breeding season. C1 [Butler, Luke K.; Romero, L. Michael] Tufts Univ, Dept Biol, Medford, MA 02155 USA. [Hayden, Timothy J.] Engineer Res & Dev Ctr, Army Endangered Species Res Program, Champaign, IL 61826 USA. RP Butler, LK (reprint author), Tufts Univ, Dept Biol, Medford, MA 02155 USA. EM luke.butler@tufts.edu FU Strategic Environmental Research and Development Program [1396] FX We thank J. Barry, J. Brown, C. Butler Jr., B. Cook, L. Duda, E. Fergus, J. Ferrer, E. Gill, M. Vinson, and A. Whitley for field assistance, J. Cornelius for logistical support at Fort Hood, and the staffs at the ornithology sections of the six museums we visited. I. Bisson provided invaluable assistance with many aspects of this work. S. Rohwer, E. Willoughby, and an anonymous reviewer improved the manuscript. This project was funded by Strategic Environmental Research and Development Program grant 1396, but the contents of this paper do not necessarily reflect the position or views of the U.S. government. NR 63 TC 9 Z9 9 U1 0 U2 9 PU COOPER ORNITHOLOGICAL SOC PI LAWRENCE PA ORNITHOLOGICAL SOC NORTH AMER PO BOX 1897, LAWRENCE, KS 66044-8897 USA SN 0010-5422 EI 1938-5129 J9 CONDOR JI Condor PD AUG PY 2008 VL 110 IS 3 BP 428 EP 440 DI 10.1525/cond.2008.8565 PG 13 WC Ornithology SC Zoology GA 369ZI UT WOS:000260732000003 ER PT J AU Firoz, BF Kennedy, JS Henning, JS AF Firoz, Bahar F. Kennedy, Jeremy S. Henning, Jeffrey Scott TI Dermoscopy and suture marking as a tool to enhance diagnosis of pigmented lesions SO DERMATOLOGIC SURGERY LA English DT Editorial Material ID MELANOCYTIC SKIN-LESIONS; EPILUMINESCENCE MICROSCOPY; PATTERN-ANALYSIS; ABCD RULE; DERMATOSCOPY; MELANOMAS C1 [Kennedy, Jeremy S.; Henning, Jeffrey Scott] Brooke Army Med Ctr, Dept Dermatol, Ft Sam Houston, TX 78234 USA. [Firoz, Bahar F.] NYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY USA. RP Henning, JS (reprint author), Brooke Army Med Ctr, Dept Dermatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jeffrey.henning@amedd.army.mil NR 12 TC 3 Z9 3 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD AUG PY 2008 VL 34 IS 8 BP 1104 EP 1107 DI 10.1111/j.1524-4725.2008.34220.x PG 4 WC Dermatology; Surgery SC Dermatology; Surgery GA 332HA UT WOS:000258072100020 PM 18462413 ER PT J AU Cropek, DM Esarey, JC Conner, CL Goran, JM Smith, T Soucek, DJ AF Cropek, Donald M. Esarey, Joan C. Conner, Cassie L. Goran, Jacob M. Smith, Thomas Soucek, David J. TI Toxicological effects of military fog oil obscurant on Daphnia magna and Ceriodaphnia dubia in field and laboratory exposures SO ECOTOXICOLOGY LA English DT Article DE fog oil; military obscurants; Daphnia magna; Ceriodaphnia dubia ID POLYCYCLIC AROMATIC-HYDROCARBONS; PHOTOENHANCED TOXICITY; WEATHERED OIL; CRUDE-OIL; PHOTOTOXICITY; MORTALITY; PETROLEUM AB Our purpose was to determine if the acute and sub-lethal effects of fog oil, an obscurant used for military training, could be observed in realistic field exposures. To this end, we exposed Daphnia magna to oil fogs under actual release conditions at a U.S. Army training site. Guided by field investigations, acute toxicity experiments were conducted in the laboratory with the more sensitive species Ceriodaphnia dubia to test the hypothesis that dissolution of fog oil constituents into water is minimal and actual contact by organisms with the water surface is required to cause toxicity. We conducted further experiments to test the hypothesis that vaporization of fog oil alters its chemical composition and toxicity to freshwater invertebrates. In the field, daphnid mortality was minimal more than 5 m from the point of fog generation, but sub-lethal effects were more extensive. Both field and laboratory experiments suggested that physical contact with oils on the water surface was the most important factor driving toxicity. To our knowledge, this is the first attempt to evaluate toxicological endpoints with freshwater invertebrates in field exposures with fog oil. C1 [Esarey, Joan C.; Soucek, David J.] Illinois Nat Hist Survey, Champaign, IL 61820 USA. [Cropek, Donald M.; Conner, Cassie L.; Goran, Jacob M.; Smith, Thomas] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Soucek, DJ (reprint author), Illinois Nat Hist Survey, 1816 S Oak St, Champaign, IL 61820 USA. EM d-soucek@inhs.uiuc.edu NR 24 TC 2 Z9 2 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 J9 ECOTOXICOLOGY JI Ecotoxicology PD AUG PY 2008 VL 17 IS 6 BP 517 EP 525 DI 10.1007/s10646-008-0207-z PG 9 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 315WH UT WOS:000256910400009 PM 18392677 ER PT J AU Boonsong, K Caulum, MM Dressen, BM Chailapakul, O Cropek, DM Henry, CS AF Boonsong, Kanokporn Caulum, Meghan M. Dressen, Brian M. Chailapakul, Orawon Cropek, Donald M. Henry, Charles S. TI Influence of polymer structure on electroosmotic flow and separation efficiency in successive multiple ionic layer coatings for microchip electrophoresis SO ELECTROPHORESIS LA English DT Article DE microchip electrophoresis; microfluidics; PDMS; successive multiple ionic layer coating; surface modification ID CAPILLARY ELECTROKINETIC CHROMATOGRAPHY; POLYELECTROLYTE MULTILAYERS; MICROFLUIDIC DEVICES; SURFACE MODIFICATION; POLY(DIMETHYLSILOXANE) MICROCHIPS; FLUORESCENCE DETECTION; ZONE ELECTROPHORESIS; MOLECULAR-WEIGHT; SYSTEMS; ADSORPTION AB The effect of successive multiple ionic layer (SMIL) coatings on the velocity and direction of EOF and the separation efficiency for PDMS electrophoresis microchips was studied using different polymer structures and deposition conditions. To date, the majority of SMIL studies have used traditional CE and fused-silica capillaries. EOF was measured as a function of polymer structure and number of layers, in one case using the same anionic polymer and varying the cationic polymer and in the second case using the same cationic polymer and varying the anionic polymer. In both situations, the EOF direction reversed with each additional deposited polymer layer. The absolute EOF magnitude, however, did not vary significantly with layer number or polymer structure. Next, different coatings were used to compare separation efficiencies on native and SMIL-coated PDMS microchips. For native PDMS microchips, the average separation efficiency was 4105 +/- 1540 theoretical plates. The addition of two layers of polymer increased the separation efficiency anywhere from two- to five-fold, depending on the polymer structure. A maximum separation efficiency of 12 880 +/- 1050 theoretical plates was achieved for SMIL coatings of polybrene (cationic) and dextran sulfate (anionic) polymers after deposition of six total layers. It was also noted that coating improved run-to-run consistency of the peaks as noted by a reduction of the RSD of the EOF and separation efficiency. This study shows that the use of polyelectrolyte coatings, irrespective of the polymer structure, generates a consistent EOF in the current experiments and dramatically improves the separation efficiency when compared to unmodified PDMS microchips. C1 [Caulum, Meghan M.; Dressen, Brian M.; Henry, Charles S.] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA. [Boonsong, Kanokporn; Chailapakul, Orawon] Chulalongkorn Univ, Fac Sci, Dept Chem, Sensor Res Unit, Bangkok, Thailand. [Boonsong, Kanokporn] Rajamangala Univ, Fac Sci & Technol, Dept Sci, Div Chem, Bangkok, Thailand. [Cropek, Donald M.] USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61824 USA. RP Henry, CS (reprint author), Colorado State Univ, Dept Chem, 200 W Lake St, Ft Collins, CO 80523 USA. EM chuck.henry@colostate.edu OI Henry, Charles/0000-0002-8671-7728 FU US Army Corps of Engineers; Thailand Research Fund [PHD/0063/2547] FX The authors thank the US Army Corps of Engineers for financial support. K. B. was supported by a fellowship from the Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program (grant no. PHD/0063/2547).; The authors have declared no conflict of interest. NR 53 TC 21 Z9 21 U1 2 U2 26 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0173-0835 J9 ELECTROPHORESIS JI Electrophoresis PD AUG PY 2008 VL 29 IS 15 BP 3128 EP 3134 DI 10.1002/elps.200800186 PG 7 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 340EP UT WOS:000258629200005 PM 18633945 ER PT J AU Adams, BD Barry, DJ AF Adams, Bruce D. Barry, David J. TI Tiagabine: Let seizing dogs lie? SO EMERGENCY MEDICINE AUSTRALASIA LA English DT Letter ID STATUS EPILEPTICUS C1 [Adams, Bruce D.] William Beaumont Army Med Ctr, Dept Clin Invest, El Paso, TX 79920 USA. [Barry, David J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Adams, BD (reprint author), William Beaumont Army Med Ctr, Dept Clin Invest, El Paso, TX 79920 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1742-6731 J9 EMERG MED AUSTRALAS JI Emerg. Med. Australas. PD AUG PY 2008 VL 20 IS 4 BP 370 EP 370 DI 10.1111/j.1742-6723.2008.01099.x PG 1 WC Emergency Medicine SC Emergency Medicine GA 332QP UT WOS:000258098500012 PM 18782211 ER PT J AU Gwinn, DE Keeling, J Froehner, JW McGuigan, FX Andersen, R AF Gwinn, David E. Keeling, John Froehner, Jerald W. McGuigan, Francis X. Andersen, Romney TI Perioperative differences between bone bridging and non-bone bridging transtibial amputations for wartime lower extremity trauma SO FOOT & ANKLE INTERNATIONAL LA English DT Article ID TRANS-TIBIAL AMPUTATION; PNEUMATIC TOURNIQUET; RISK-FACTORS; COMPLICATIONS; AMPUTEES; DISTAL AB Background: The distal bone bridge transtibial amputation technique requires additional intraoperative surgical steps when compared to the non-bone bridging technique. Comparative functional data is not available showing a clearly superior outcome from either technique. Identifying perioperative differences could influence a surgeon's decision regarding the technique of amputation to be performed. This study's purpose was to compare perioperative differences between bone bridging transtibial amputation and non-bone bridging amputation techniques. Materials and Methods: A retrospective review from April 2004 to April 2007 identified 37 consecutive patients with 42 transtibial amputations as a result of wartime blast injuries. Twenty-two non-bone bridging and twenty bone bridging amputations were performed. Statistical comparisons of intraoperative time, tourniquet time, estimated blood loss, the need for postoperative transfusion and frequency of wound complications was performed. Results: The bone bridging amputation technique had significantly longer operative times (178.5 vs. 112.2 minutes, p < 0.0005) and tourniquet times (114.8 vs. 71.0 minutes, p < 0.0005). Regardless of technique used, amputations performed within the zone of injury had a 66.7% wound complication rate (p < 0.0005). There was not a statistically significant difference in reoperation for wound complications between groups when controlling for zone of injury: bone bridge (6.3%) and non-bone bridge (0.0%). Amputation closure performed within the zone of injury was a significant predictor for subsequent wound problems regardless of amputation technique. Conclusion: Longer operative and tourniquet times should not be considered a contraindication to utilizing the bone bridging amputation technique in younger and otherwise healthy patients. Both amputation techniques have comparable rates of short term wound complications and associated blood loss. Wound closure for traumatic amputations should not be perfumed through the zone of injury. C1 [Gwinn, David E.; Keeling, John; Froehner, Jerald W.] Natl Naval Med Ctr, Orthoped Surg Serv, Gaithersburg, MD 20899 USA. [McGuigan, Francis X.] Georgetown Univ Hosp, Dept Orthoped Surg, Washington, DC 20007 USA. [Andersen, Romney] Walter Reed Army Med Ctr, Orthoped Surg Serv, Washington, DC 20307 USA. RP Gwinn, DE (reprint author), Natl Naval Med Ctr, Orthoped Surg Serv, 8901 Wisconsin Ave, Gaithersburg, MD 20899 USA. EM gwinny13@yahoo.com NR 23 TC 14 Z9 14 U1 0 U2 2 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD AUG PY 2008 VL 29 IS 8 BP 787 EP 793 DI 10.3113/FAI.2008.0787 PG 7 WC Orthopedics SC Orthopedics GA 331VL UT WOS:000258040600003 PM 18752776 ER PT J AU Pockros, PJ Nelson, D Godofsky, E Rodriguez-Torres, M Everson, GT Fried, MW Ghalib, R Harrison, S Nyberg, L Shiffman, ML Najera, I Chan, A Hill, G AF Pockros, Paul J. Nelson, David Godofsky, Eliot Rodriguez-Torres, Maribel Everson, Gregory T. Fried, Michael W. Ghalib, Reem Harrison, Stephen Nyberg, Lisa Shiffman, Mitchell L. Najera, Isabel Chan, Anna Hill, George TI R1626 plus peginterferon alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin SO HEPATOLOGY LA English DT Article ID RANDOMIZED-TRIAL; INTERFERON; INHIBITOR; R1479; RESISTANCE; INFECTION; ALPHA-2B AB R1626, a prodrug of the hepatitis C virus (HCV) RNA polymerase inhibitor R1479, showed time-dependent and dose-dependent reduction of HCV RNA levels in a previous study. The present study evaluated the efficacy and safety of R1626 administered for 4 weeks in combination with peginterferon alfa-2a +/- ribavirin in HCV genotype 1-infectcd treatment-naive patients. Patients were randomized to: DUAL 1500 (1500 mg R1626 twice daily [bid] + peginterferon alfa-2a; n = 21); DUAL 3000 (3000 mg R1626 bid + peginterferon alfa-2a, n = 32); TRIPLE 1500 (1500 mg R1626 bid + peginterferon alfa-2a + ribavirin; n = 31); or standard of care (SOC) (peginterferon alfa-2a + ribavirin; n = 20). At 4 weeks HCV RNA was undetectable (< 15 IU/mL) in 29%, 69%, and 74% of patients in the DUAL 1500, DUAL 3000, and TRIPLE 1500 arms, respectively, compared with 5% of patients receiving SOC, with respective mean reductions in HCV RNA from baseline to week 4 of 3.6, 4.5, 5.2, and 2.4 log(10) IU/mL. Synergy was observed between R1626 and peginterferon alfa-2a and between R1626 and ribavirin. There was no evidence of development of viral resistance. Adverse events (AEs) were mainly mild or moderate; seven patients had nine serious AEs (including one patient with one serious AE in SOC). The incidence of Grade 4 neutropenia was 48%, 78%, 39%, and 10% in DUAL 1500, DUAL 3000, TRIPLE 1500, and SOC, respectively, and was the main reason for dose reductions. Conclusion: A synergistic antiviral effect was observed when R1626 was combined with peginterferon alfa-2a +/- ribavirin; up to 74% of patients had undetectable HCV RNA at week 4. Dosing of R1626 was limited by neutropenia; a study of different dosages of R1626 in combination with peginterferon alfa-2a and ribavirin is underway. C1 [Pockros, Paul J.] Scripps Clin, Div Gastroenterol & Hepatol, La Jolla, CA 92037 USA. [Nelson, David] Univ Florida, Div Gastroenterol Hepatol & Nutr, Gainesville, FL USA. [Godofsky, Eliot] Univ Hepatitis Ctr Bach & Godofsky, Bradenton, FL USA. [Rodriguez-Torres, Maribel] Fdn Invest Diego, San Juan, PR USA. [Everson, Gregory T.] Univ Colorado, Hlth Sci Ctr, Div Gastroenterol, Sect Hepatol, Denver, CO USA. [Fried, Michael W.] Univ N Carolina, Dept Med, Chapel Hill, NC USA. [Ghalib, Reem] Dallas Methodist Hosp, Liver Inst, Dallas, TX USA. [Harrison, Stephen] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Nyberg, Lisa] Kaiser Permanente, San Diego, CA USA. [Shiffman, Mitchell L.] Virginia Commonwealth Univ, Med Ctr, Hepatol Sect, Richmond, VA USA. [Najera, Isabel; Hill, George] Roche Pharmaceut LLC, Palo Alto, CA USA. [Chan, Anna] Hoffmann La Roche Inc, Nutley, NJ 07110 USA. RP Pockros, PJ (reprint author), Scripps Clin, Div Gastroenterol & Hepatol, 10666 N Torrey Pines Rd, La Jolla, CA 92037 USA. EM pockros.paul@scrippshealth.org NR 22 TC 80 Z9 85 U1 1 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD AUG PY 2008 VL 48 IS 2 BP 385 EP 397 DI 10.1002/hep.22357 PG 13 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 334UT UT WOS:000258247400006 PM 18570306 ER PT J AU Ayubi, FS Armstrong, PJ Mattia, MS Parker, DM AF Ayubi, F. S. Armstrong, P. J. Mattia, M. S. Parker, D. M. TI Abdominal wall hernia repair: a comparison of Permacol (R) and Surgisis (R) grafts in a rat hernia model SO HERNIA LA English DT Article DE Surgisis; Permacol; Abdominal wall reconstruction; Hernia; Mesh; Collagen; Porcine ID SMALL-INTESTINAL SUBMUCOSA; LONG-TERM COMPLICATIONS; INCISIONAL HERNIA; COMPOSITE MESH; POLYPROPYLENE; OUTCOMES; SUTURE AB Background This study compared two porcine-derived grafts Permacol (Tissue Science Laboratory, Covington, GA, USA) and Surgisis (Cook Surgical, Bloomington, IN, USA) in terms of strength of incorporation (SOI), incorporation of host tissue, and adhesion formation using a rat model. Methods A prospective randomized study using 48 Sprague-Dawley rats. A standardized 1.5 x 5 cm fascial defect was created and repaired with either Permacol or Surgisis grafts. The rats were then sacrificed at 3, 14, 28, or 60 days. The specimens were examined for SOI, neovascularization, collagen deposition, collagen organization, and adhesion formation. Results Surgisis had significantly greater SOI than Permacol at 28 (0.115 vs. 0.0754 Mpa) and 60 days (0.131 vs. 0.635 Mpa). Surgisis had significantly more collagen deposition and neovascularization than Permacol at 60 days. The area of adhesions was not significantly different between Surgisis and Permacol. Conclusion Surgisis is superior to Permacol in terms of SOI and tissue ingrowth at 60 days. Furthermore, Surgisis strengthened over time whereas Permacol decreased in strength. C1 [Ayubi, F. S.; Armstrong, P. J.; Parker, D. M.] Eisenhower Army Med Ctr, Gen Surg Serv, Ft Gordon, GA 30905 USA. [Mattia, M. S.] Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. RP Parker, DM (reprint author), Eisenhower Army Med Ctr, Gen Surg Serv, Bldg 300, Ft Gordon, GA 30905 USA. EM david.parker@se.amedd.army.mil FU Department of Clinical Investigation under DDEAMC [07-5A] FX Funding for this study was provided by the Department of Clinical Investigation under DDEAMC 07-5A. No financial support was received for this study. There are no conflicts of interest. The authors have no financial ties to or interest in the manufacturers of Permacol (R) or Surgisis (R). NR 24 TC 35 Z9 37 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1265-4906 J9 HERNIA JI Hernia PD AUG PY 2008 VL 12 IS 4 BP 373 EP 378 DI 10.1007/s10029-008-0359-z PG 6 WC Surgery SC Surgery GA 371JG UT WOS:000260827000007 PM 18330666 ER PT J AU Perlman, B Laskar, J Lim, K AF Perlman, Barry Laskar, Joy Lim, Kyutae TI Fine-tuning commercial and military radio design SO IEEE MICROWAVE MAGAZINE LA English DT Article ID NETWORKS C1 [Perlman, Barry] US Army Commun Elect Res, Dev & Engn Ctr CERDEC, Ft Monmouth, NJ USA. [Laskar, Joy; Lim, Kyutae] Georgia Inst Technol, GEDC, Atlanta, GA 30332 USA. RP Perlman, B (reprint author), US Army Commun Elect Res, Dev & Engn Ctr CERDEC, Ft Monmouth, NJ USA. NR 22 TC 12 Z9 12 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1527-3342 J9 IEEE MICROW MAG JI IEEE Microw. Mag. PD AUG PY 2008 VL 9 IS 4 BP 95 EP 106 DI 10.1109/MMM.2008.924969 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 328UW UT WOS:000257824700013 ER PT J AU Torrieri, D Cheng, S Valenti, MC AF Torrieri, Don Cheng, Shi Valenti, Matthew C. TI Robust frequency hopping for interference and fading channels SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article; Proceedings Paper CT IEEE International Conference on Communications (ICC 2007) CY JUN 24-28, 2007 CL Glasgow, SCOTLAND SP IEEE DE frequency hopping; partial-band interference; multiple-access interference; frequency-selective fading; continuous-phase frequency-shift keying ID ITERATIVE DEMODULATION; MODULATION AB A robust frequency-hopping system with noncoherent detection, iterative turbo decoding and demodulation, and channel estimation is presented. The data modulation is the spectrally compact nonorthogonal continuous-phase frequency-shift keying, which strengthens the frequency-hopping system against multiple-access interference and multitone jamming. An analysis based on information theory provides the optimal values of the modulation index when there is a bandwidth constraint. The channel estimator, which is derived by applying the expectation-maximization algorithm, accommodates both frequency-selective fading and interference. Simulation experiments demonstrate the excellent system performance against both partial-band and multiple-access interference. C1 [Torrieri, Don] USA, Res Lab, Adelphi, MD USA. [Cheng, Shi] ArrayComm LLC, San Jose, CA USA. [Valenti, Matthew C.] W Virginia Univ, Morgantown, WV 26506 USA. RP Torrieri, D (reprint author), USA, Res Lab, Adelphi, MD USA. EM dtorr@arl.army.mil; shi.cheng@gmail.com; mvalenti@csee.wvu.edu OI Valenti, Matthew/0000-0001-6089-0509 NR 13 TC 10 Z9 10 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD AUG PY 2008 VL 56 IS 8 BP 1343 EP 1351 DI 10.1109/TCOMM.2008.060549 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 339IT UT WOS:000258572000018 ER PT J AU Lelis, AJ Habersat, D Green, R Ogunniyi, A Gurfinkel, M Suehle, J Goldsman, N AF Lelis, Aivars J. Habersat, Daniel Green, Ronald Ogunniyi, Aderinto Gurfinkel, Moshe Suehle, John Goldsman, Neil TI Time dependence of bias-stress-induced SiC MOSFET threshold-voltage instability measurements SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE MOSFETs; oxide charge trapping; silicon carbide (SiC); tunneling model ID SILICON-CARBIDE; OXIDE CHARGES; NITRIC-OXIDE; INTERFACE; DEVICES; MOBILITY; CENTERS; TRAPS; N2O AB We have observed significant instability in the threshold voltage of 4H-SiC metal-oxide-semiconductor field-effect transistors due to gate-bias stressing. This effect has a strong measurement time dependence. For example, a 20-ps-long gate ramp used to measure the I-V characteristic and extract a threshold voltage was found to result in a VT instability three to four times greater than that measured with a I-s-long gate ramp. The VT instability was three times greater in devices that did not receive a NO postoxidation anneal compared with those that did. This instability effect is consistent with electrons directly tunneling in and out of near-interfacial oxide traps, which in irradiated Si MOS was attributed to border traps. C1 [Lelis, Aivars J.; Habersat, Daniel; Green, Ronald; Ogunniyi, Aderinto] USA, Res Lab, Adelphi, MD 20783 USA. [Gurfinkel, Moshe; Suehle, John] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Goldsman, Neil] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Lelis, AJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM alelis@arl.army.mil; dahabersat@arl.army.mil; rgreen@arl.army.mil; aderinto.ogunniyi@arl.army.mil; moshegur@gmail.com; john.suehle@nist.gov; neil@umd.edu NR 33 TC 101 Z9 102 U1 5 U2 26 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD AUG PY 2008 VL 55 IS 8 BP 1835 EP 1840 DI 10.1109/TED.2008.926672 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 330NO UT WOS:000257950300009 ER PT J AU Gurfinkel, M Xiong, HD Cheung, KP Suehle, JS Bernstein, JB Shapira, Y Lelis, AJ Habersat, D Goldsman, N AF Gurfinkel, Moshe Xiong, Hao D. Cheung, Kin P. Suehle, John S. Bernstein, Joseph B. Shapira, Yoram Lelis, Aivars J. Habersat, Daniel Goldsman, Neil TI Characterization of transient gate oxide trapping in SiC MOSFETs using fast I-V techniques SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE annealing; charge carrier processes; reliability; silicon carbide; transient trapping ID SILICON-CARBIDE; 4H-SIC MOSFETS; MOS CAPACITORS; NITRIC-OXIDE; INTERFACE; MOBILITY; TEMPERATURE; POLYTYPE; VOLTAGE AB Threshold voltage and drain current instabilities in state-of-the-art 4H-SiC MOSFETs with thermal as-grown SiO(2) and NO-annealed gate oxides have been studied using fast I-V measurements. These measurements reveal the full extent of the instability underestimated by dc measurements. Furthermore, fast measurements allow the separation of negative and positive bias stress effects. Postoxidation annealing in NO was found to passivate the oxide traps and dramatically reduce the instability. A physical model involving fast transient charge trapping and detrapping at and near the SiC/SiO(2) interface is proposed. C1 [Gurfinkel, Moshe; Shapira, Yoram] Tel Aviv Univ, Sch Elect Engn, IL-69978 Tel Aviv, Israel. [Xiong, Hao D.; Cheung, Kin P.; Suehle, John S.] NIST, Gaithersburg, MD 20899 USA. [Bernstein, Joseph B.] Bar Ilan Univ, IL-52900 Ramat Gan, Israel. [Bernstein, Joseph B.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Lelis, Aivars J.; Habersat, Daniel] Army Res Labs, Adelphi, MD 20783 USA. [Goldsman, Neil] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Gurfinkel, M (reprint author), Tel Aviv Univ, Sch Elect Engn, IL-69978 Tel Aviv, Israel. EM moshegur@post.tau.ac.il NR 23 TC 52 Z9 53 U1 2 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD AUG PY 2008 VL 55 IS 8 BP 2004 EP 2012 DI 10.1109/TED.2008.926626 PG 9 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 330NO UT WOS:000257950300033 ER PT J AU Potbhare, S Goldsman, N Lelis, A McGarrity, JM McLean, FB Habersat, D AF Potbhare, Siddharth Goldsman, Neil Lelis, Aivars McGarrity, James M. McLean, F. Barry Habersat, Daniel TI A physical model of high temperature 4H-SiC MOSFETs SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE high-temperature mobility; high-temperature operation; interface traps; silicon carbide (SiC) MOSFET; surface roughness; velocity saturation ID FIELD-EFFECT TRANSISTORS; MONTE-CARLO METHOD; ELECTRON-TRANSPORT; SIO2/4H-SIC INTERFACE; SILICON-CARBIDE; MOBILITY; 4H; ROUGHNESS; INVERSION; 6H AB A comprehensive physical model for the analysis, characterization, and design of 4H-silicon carbide (SiC) MOSFETs has been developed. The model has been verified for an extensive range of bias conditions and temperatures. It incorporates details of interface trap densities, Coulombic interface trap scattering, surface roughness scattering, phonon scattering, velocity saturation, and their dependences on bias and temperature. The physics-based models were implemented into our device simulator that is tailored for 4H-SiC MOSFET analysis. By using a methodology of numerical modeling, simulation, and close correlation with experimental data, values for various physical parameters governing the operation of 4H-SiC MOSFETs, including the temperature-dependent interface trap density of states, the root-mean-square height and correlation length of the surface roughness, and the electron saturation velocity in the channel and its dependence on temperature, have been extracted. Coulomb scattering and surface roughness scattering limit surface mobility for a wide range of temperatures in the subthreshold and linear regions of device operation, whereas the saturation velocity and the high-field mobility limit current in the saturation region. C1 [Potbhare, Siddharth; Goldsman, Neil] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Lelis, Aivars; Habersat, Daniel] USA, Res Lab, Adelphi, MD 20783 USA. [McGarrity, James M.; McLean, F. Barry] Berkeley Res Associates Inc, Springfield, VA 22150 USA. RP Potbhare, S (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM potbhare@umd.edu NR 22 TC 46 Z9 51 U1 2 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD AUG PY 2008 VL 55 IS 8 BP 2029 EP 2040 DI 10.1109/TED.2008.926665 PG 12 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 330NO UT WOS:000257950300036 ER PT J AU Potbhare, S Goldsman, N Akturk, A Gurfinkel, M Lelis, A Suehle, JS AF Potbhare, Siddharth Goldsman, Neil Akturk, Akin Gurfinkel, Moshe Lelis, Aivars Suehle, John S. TI Energy- and time-dependent dynamics of trap occupation in 4H-SiC MOSFETs SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE SiC interface trap dynamics; surface generation-recombination; trap capture cross-section ID FIELD-EFFECT TRANSISTORS; CAPTURE CROSS-SECTION; INTERFACE TRAPS; STATES; MOBILITY; 4H AB A methodology for characterizing the transient response of 4H-SiC MOSFETs has been developed. The method combines new physical models, simulation techniques, and experiment to provide insight into the details of MOSFET time-dependent dynamics. A new physical model for generation-recombination between interface traps and channel electrons was derived, facilitating the analysis of trap dynamics in the energy, space, and time domains. A set of algorithms was developed, which enabled these rates to be incorporated into the drift-diffusion model so that their effect on the switching of 4H-SiC MOSFETs could be numerically evaluated. The correlation of simulated and experimental dc and transient drain current allowed the extraction of the density and the effective capture cross sections of interface traps. It was found that states near the band edge would become occupied much more quickly and had a much larger effective capture cross section than those that were several tenths of an electronvolt away from the band edge. This has led to the conclusion that the fast traps with large capture cross sections are likely to be interface states, whereas the traps with the smaller capture cross sections are a combination of midgap interface states and oxide traps. The observation of trap dynamics suggests that improvements in long-term device stability can be achieved by reducing oxide traps, whereas short-term stability can be improved by the reduction of interface traps. C1 [Potbhare, Siddharth; Goldsman, Neil; Akturk, Akin] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Gurfinkel, Moshe] Tel Aviv Univ, Sch Elect Engn, IL-66978 Tel Aviv, Israel. [Lelis, Aivars] USA, Res Lab, Adelphi, MD 20783 USA. [Suehle, John S.] NIST, Div Semicond Elect, Gaithersburg, MD 20899 USA. RP Potbhare, S (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM potbhare@umd.edu; neil@umd.edu NR 20 TC 22 Z9 22 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD AUG PY 2008 VL 55 IS 8 BP 2061 EP 2070 DI 10.1109/TED.2008.926668 PG 10 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 330NO UT WOS:000257950300040 ER PT J AU Misra, S Tong, L AF Misra, Saswat Tong, Lang TI Error exponents for the detection of Gauss-Markov signals using randomly spaced sensors SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE error exponent; Gauss-Markov; Neyman-Pearson detection; optimal placement density; sensors ID CORRELATED LOCAL DECISIONS; DISTRIBUTED DETECTION; FADING CHANNELS; NETWORKS; FUSION AB We derive the Neyman-Pearson error exponent for the detection of Gauss-Markov signals using randomly spaced sensors. We assume that the sensor spacings, d(1), d(2),..., are drawn independently from a common density f(d)(.), and we treat both stationary and nonstationary Markov models. Error exponents are evaluated using specialized forms of the Strong Law of Large Numbers, and are seen to take on algebraically simple forms involving the parameters of the Markov processes and expectations over f(d)(.) of certain functions of d(1). These expressions are evaluated explicitly when, f(d)(.) corresponds to i) exponentially distributed sensors with placement density lambda; ii) equally spaced sensors; and iii) the proceeding cases when sensors fail (or equivalently, are asleep) with probability q. Many insights follow. For example, we determine the optimal lambda as a function of q in the nonstationary case. Numerical simulations show that the error exponent predicts trends of the simulated error rate accurately even for small data sizes. C1 [Misra, Saswat] USA, Res Lab, Adelphi, MD 20783 USA. [Tong, Lang] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. RP Misra, S (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM sm353@cornell.edu; ltong@ece.cornell.edu NR 28 TC 8 Z9 8 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD AUG PY 2008 VL 56 IS 8 BP 3385 EP 3396 DI 10.1109/TSP.2008.919106 PN 1 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA 331SL UT WOS:000258032800001 ER PT J AU Miller, AL Clark, OE Cario, CL Nealley, EW Kan, RK Smith, WJ AF Miller, Adele L. Clark, Offie E. Cario, Clinton L. Nealley, Eric W. Kan, Robert K. Smith, William J. TI Evaluation of cytokine activity of three human tissue constructs for in vitro sulfur mustard research SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Miller, Adele L.; Clark, Offie E.; Cario, Clinton L.; Nealley, Eric W.; Kan, Robert K.; Smith, William J.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. EM William.j.smith3@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD AUG PY 2008 VL 44 IS 7 BP 297 EP 298 PG 2 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 341HK UT WOS:000258704600019 ER PT J AU Clark, OE Nealley, EW Miller, AL Cario, CL Jung, YS Smith, WJ AF Clark, Offie E. Nealley, Eric W. Miller, Adele L. Cario, Clinton L. Jung, Young-Sik Smith, William J. TI The protective effect of capsaicin analog treatment on human bronchial cells exposed in culture to sulfur mustard (HD) SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Meeting Abstract C1 [Clark, Offie E.; Nealley, Eric W.; Miller, Adele L.; Cario, Clinton L.; Smith, William J.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Jung, Young-Sik] Korea Res Inst Chem Technol, Taejon 305606, South Korea. EM William.j.smith3@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD AUG PY 2008 VL 44 IS 7 BP 298 EP 298 PG 1 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA 341HK UT WOS:000258704600020 ER PT J AU Arlen, PA Singleton, M Adamovicz, JJ Ding, Y Davoodi-Semiromi, A Daniell, H AF Arlen, Philip A. Singleton, Michael Adamovicz, Jeffrey J. Ding, Yi Davoodi-Semiromi, Abdolreza Daniell, Henry TI Effective plague vaccination via oral delivery of plant cells expressing F1-V antigens in chloroplasts SO INFECTION AND IMMUNITY LA English DT Article ID RECOMBINANT V-ANTIGEN; TRANSGENIC TOBACCO CHLOROPLASTS; HETEROLOGOUS PRIME-BOOST; YERSINIA-PESTIS ANTIGENS; PNEUMONIC PLAGUE; IMMUNE-RESPONSE; PROTECTS MICE; FUSION PROTEIN; CHOLERA-TOXIN; ACTIVE IMMUNIZATION AB The chloroplast bioreactor is an alternative to fermentation-based systems for production of vaccine antigens and biopharmaceuticals. We report here expression of the plague FIN fusion antigen in chloroplasts. Site-specific transgene integration and homoplasmy were confirmed by PCR and Southern blotting. Mature leaves showed the highest level of transgene expression on the third day of continuous illumination, with a maximum level of 14.8% of the total soluble protein. Swiss Webster mice were primed with adjuvant-containing subcutaneous (s.c.) doses of F1-V and then boosted with either adjuvanted s.c. doses (s.c. FIN mice) or unadjuvanted oral doses (oral F1-V mice). Oral FIN mice had higher prechallenge serum immunoglobulin G1 (IgG1) titers than s.c. F1-V mice. The corresponding serum levels of antigen-specific IgG2a and IgA were 2 and 3 orders of magnitude lower, respectively. After vaccination, mice were exposed to an inhaled dose of 1.02 X 10(6) CFU of aerosolized Yersinia pestis CO92 (50% lethal dose, 6.8 X 10(4) CFU). All control animals died within 3 days. F1-V given s.c. (with adjuvant) protected 33% of the immunized mice, while 88% of the oral F1-V mice survived aerosolized Y. pestis challenge. A comparison of splenic Y. pestis CFU counts showed that there was a 7- to 10-log reduction in the mean bacterial burden in survivors. Taken together, these data indicate that oral booster doses effectively elicit protective immune responses in vivo. In addition, this is the first report of a plant-derived oral vaccine that protected animals from live Y. pestis challenge, bringing the likelihood of lower-cost vaccines closer to reality. C1 [Arlen, Philip A.; Singleton, Michael; Ding, Yi; Davoodi-Semiromi, Abdolreza; Daniell, Henry] Univ Cent Florida, Coll Med, Dept Mol Biol & Microbiol, Orlando, FL 32816 USA. [Adamovicz, Jeffrey J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Daniell, H (reprint author), Univ Cent Florida, Coll Med, Dept Mol Biol & Microbiol, 4000 Cent Florida Blvd,Biomol Sci Bldg 20,Room 33, Orlando, FL 32816 USA. EM daniell@mail.ucf.edu OI Daniell, Henry/0000-0003-4485-1176 FU USDA [3611-21000-017-00D]; NIH [5R01 GM 63879-06]; DTRA research plan [A2-X002-04-RD-B] FX This investigation was supported in part by USDA grant 3611-21000-017-00D and NIH grant 5R01 GM 63879-06 to Henry Daniell and by DTRA research plan A2-X002-04-RD-B to Jeffrey Adamovicz. We are grateful to Bob Banks of the UCF Wild Animal Facility for help with the handling of animals. NR 98 TC 79 Z9 93 U1 0 U2 10 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD AUG PY 2008 VL 76 IS 8 BP 3640 EP 3650 DI 10.1128/IAI.00050-08 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 338BW UT WOS:000258480900029 PM 18505806 ER PT J AU Courtney, M Courtney, A AF Courtney, Michael Courtney, Amy TI Comments on "Ballistics: A primer for the surgeon" SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Letter ID MISSILE EXTREMITY IMPACT; PRESSURE WAVE INJURIES; NERVOUS-SYSTEM; PIGS; TRAUMA; DAMAGE; BRAIN; LIGHT C1 [Courtney, Michael] Ballist Testing Grp, West Point, NY 10996 USA. [Courtney, Amy] US Mil Acad, Dept Phys, West Point, NY 10996 USA. RP Courtney, M (reprint author), Ballist Testing Grp, POB 24, West Point, NY 10996 USA. EM Michael_Courtney@alum.mit.edu NR 18 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD AUG PY 2008 VL 39 IS 8 BP 964 EP 965 DI 10.1016/j.injury.2008.03.020 PG 2 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 337JN UT WOS:000258432500024 PM 18620354 ER PT J AU Oudkerk, M Stillman, AE Halliburton, SS Kalender, WA Mohlenkamp, S McCollough, CH Vliegenthart, R Shaw, LJ Stanford, W Taylor, AJ van Ooijen, PMA Wexler, L Raggi, P AF Oudkerk, Matthijs Stillman, Arthur E. Halliburton, Sandra S. Kalender, Willi A. Moehlenkamp, Stefan McCollough, Cynthia H. Vliegenthart, Rozemarijn Shaw, Leslee J. Stanford, William Taylor, Allen J. van Ooijen, Peter M. A. Wexler, Lewis Raggi, Paolo TI Coronary artery calcium screening: current status and recommendations from the European Society of Cardiac Radiology and North American Society for Cardiovascular Imaging SO INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING LA English DT Review DE coronary artery calcium; coronary artery atherosclerosis; coronary risk assessment; coronary artery CT ID BEAM COMPUTED-TOMOGRAPHY; ALL-CAUSE MORTALITY; HEART-DISEASE EVENTS; STAGE RENAL-DISEASE; ACUTE MYOCARDIAL-INFARCTION; EXPERT CONSENSUS DOCUMENT; LIPID-LOWERING THERAPY; ACUTE CHEST-PAIN; RISK-FACTORS; PROGNOSTIC VALUE AB Current guidelines and literature on screening for coronary artery calcium for cardiac risk assessment are reviewed for both general and special populations. It is shown that for both general and special populations a zero score excludes most clinically relevant coronary artery disease. The importance of standardization of coronary artery calcium measurements by multi-detector CT is discussed. C1 [Oudkerk, Matthijs; Vliegenthart, Rozemarijn; van Ooijen, Peter M. A.] Univ Groningen, Dept Radiol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands. [Stillman, Arthur E.; Shaw, Leslee J.; Raggi, Paolo] Emory Univ, Dept Radiol, Atlanta, GA 30322 USA. [Halliburton, Sandra S.] Cleveland Clin Fdn, Imaging Inst, Cardiovasc Imaging Lab, Cleveland, OH 44195 USA. [Kalender, Willi A.] Univ Erlangen Nurnberg, Inst Med Phys, Erlangen, Germany. [Moehlenkamp, Stefan] Univ Duisburg Essen, W German Heart Ctr Essen, Essen, Germany. [McCollough, Cynthia H.] Mayo Clin, Dept Radiol, Rochester, MN USA. [Stanford, William] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA. [Taylor, Allen J.] Walter Reed Army Med Ctr, Div Cardiol, Washington, DC 20307 USA. [Wexler, Lewis] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA. RP Oudkerk, M (reprint author), Univ Groningen, Dept Radiol, Univ Med Ctr Groningen, Hanzepl 1, NL-9700 RB Groningen, Netherlands. EM M.Oudkerk@rad.umcg.nl RI van Ooijen, Peter/B-9150-2008; van Ooijen, Peter/G-1146-2012 OI van Ooijen, Peter/0000-0002-8995-1210; van Ooijen, Peter/0000-0002-8995-1210 FU NIBIB NIH HHS [R01 EB007986, R01 EB007986-02] NR 142 TC 55 Z9 56 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1569-5794 J9 INT J CARDIOVAS IMAG JI Int. J. Cardiovasc. Imaging PD AUG PY 2008 VL 24 IS 6 BP 645 EP 671 DI 10.1007/s10554-008-9319-z PG 27 WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine & Medical Imaging GA 331AW UT WOS:000257986100012 PM 18504647 ER PT J AU Anderson, CE Behner, T Orphal, DL Nicholls, AE Templeton, DW AF Anderson, Charles E., Jr. Behner, Thilo Orphal, Dennis L. Nicholls, Arthur E. Templeton, Douglas W. TI Time-resolved penetration into pre-damaged hot-pressed silicon carbide SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE silicon carbide; time-resolved penetration; penetration velocity; in-situ comminution; compacted powder ID LONG-ROD PENETRATION; TUNGSTEN PROJECTILES; CAVITY EXPANSION; INTERFACE DEFEAT; IMPACT; VELOCITIES; TRANSITION; TARGETS AB We have conducted a series of experiments to examine projectile penetration of cylindrical hot-pressed silicon carbide (SiC) ceramic targets that are pre-damaged to varying degrees under controlled laboratory conditions prior to ballistic testing. SiC was thermally shocked to introduce non-contiguous cracks. Another set of targets was thermally shocked and then additional damage was induced by load-unload cycling in an MTS machine while the ceramic specimen was confined in a 7075-T6 aluminum sleeve. Finally, targets were made by compacting SiC powder into a 7075-T6 aluminum sleeve. For each of these target types, long gold rod penetration was measured as a function of impact velocity upsilon(p) over the approximate range of 1-3 km/s, with most data between 1.5 and 3 km/s. Penetration as a function of time was measured using multiple independently timed flash X-rays. Results are compared with previous results for non-damaged (intact) SiC targets. Key results from these experiments include the following: (1) penetration is nominally steady state for upsilon(p)> 1.5 km/s; (2) for all target types, the penetration velocity it is a linear function of upsilon(p) (except for the lowest impact velocities); and (3) it is found that u(intact) 50%, it is difficult to assign unambiguously whether the system is composed of a single heterogeneous particle or of multiple particles. Our calculations demonstrate optical effects attributable to multiple scattering in systems having volume densities as high as similar to 90%. This suggests that heterogeneities within naturally occurring particle systems can produce multiple-scattering effects. We also see evidence of very deep negative polarization branches (NPBs) (similar to-6%) that may have implications in interpreting polarization phase curves of cometary circumnuclear halos. Published by Elsevier Ltd. C1 [Videen, Gorden] USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. [Zubko, Evgenij] Hokkaido Univ, Inst Low Temp Sci, Kita Ku, Sapporo, Hokkaido 0600819, Japan. [Zubko, Evgenij; Shkuratov, Yuriy] Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. [Shkuratov, Yuriy] Natl Acad Sci Ukraine, Inst Radio Astron, UA-61002 Kharkov, Ukraine. [Mishchenko, Michael] NASA, Goddard Inst Space Studies, New York, NY 10025 USA. RP Videen, G (reprint author), USA, Res Lab, AMSRL CI EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gvideen@arl.army.mil RI Mishchenko, Michael/D-4426-2012 NR 76 TC 33 Z9 33 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD AUG-SEP PY 2008 VL 109 IS 12-13 BP 2195 EP 2206 DI 10.1016/j.jqsrt.2008.03.007 PG 12 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 330TT UT WOS:000257966400005 ER PT J AU Tyynela, J Muinonen, K Zubko, E Videen, G AF Tyynela, Jani Muinonen, Karri Zubko, Evgenij Videen, Gorden TI Interrelating scattering characteristics to internal electric fields for Gaussian-random-sphere particles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE negative polarization branch; Gaussian-random-sphere particles; discrete-dipole approximation ID LIGHT-SCATTERING; MATRICES AB We investigate the single-scattering interference mechanism related to the negative polarization branch (NPB) and intensity enhancement branch (IEB) near the backscattering direction for wavelength-scale Gaussian-random-sphere particles. Previously, we showed that for wavelength-scale spherical particles there is a two-part mechanism related to the longitudinal and the transverse components of the internal electric fields that are responsible for producing both the NPB and IEB near the backscattering direction. For comparison with the previous study, we have chosen the ensemble-averaged parameters of the Gaussian-random-sphere particles to be equivalent to those for spherical particles. We conclude that the same mechanism also can explain the NPB and IEB for non-spherical particles and that the mechanism seems to be stronger inside spherical particles, mainly because of stronger interference, and becomes weaker as the particle becomes more non-spherical. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Tyynela, Jani; Muinonen, Karri] Univ Helsinki, FI-00014 Helsinki, Finland. [Zubko, Evgenij] Hokkaido Univ, Inst Low Temp Sci, Kita Ku, Sapporo, Hokkaido 0600819, Japan. [Videen, Gorden] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Tyynela, J (reprint author), Univ Helsinki, Kopernikuksenkatu 1,POB 14, FI-00014 Helsinki, Finland. EM jktyynel@mappi.helsinki.fi RI Tyynela, Jani/H-4761-2011 NR 24 TC 9 Z9 9 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD AUG-SEP PY 2008 VL 109 IS 12-13 BP 2207 EP 2218 DI 10.1016/j.jqsrt.2008.04.003 PG 12 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 330TT UT WOS:000257966400006 ER PT J AU Allen, JL Jow, TR Wolfenstine, J AF Allen, J. L. Jow, T. R. Wolfenstine, J. TI Analysis of the FePO4 to LiFePO4 phase transition SO JOURNAL OF SOLID STATE ELECTROCHEMISTRY LA English DT Article; Proceedings Paper CT 4th International Conference on Materials for Advanced Technologies CY JUL 01-06, 2007 CL Singapore, SINGAPORE SP Mat Res Soc, Nanyang Technol Univ, Natl Univ Singapore, Inst Mat Res & Engn DE lithium iron phosphate; kinetics; phase transition; Avrami equation ID RECHARGEABLE LITHIUM BATTERIES; CONDUCTIVITY; NUCLEATION; KINETICS; GROWTH AB The electrochemical phase transformation of carbon coated nanophase (60-70 nm) FePO4 to LiFePO4 was investigated by use of the Avrami-Johnson-Mehl-Eroofev equation. The analysis at three temperatures showed an Avrami exponent equal to one. Based upon reinterpretation and in agreement with recent microstructural evidence, a two-dimensional growth mechanism for the phase transformation is proposed in which the new phase grows in a direction perpendicular to the direction of lithium ion transport. Furthermore, the relatively low value of the activation energy for the phase transformation of 13 kJ/mol suggests that the phase transition is controlled by lithium ion diffusion along the phase boundary. C1 [Allen, J. L.; Jow, T. R.; Wolfenstine, J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Allen, JL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM jallen@arl.army.mil NR 19 TC 29 Z9 32 U1 3 U2 31 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1432-8488 J9 J SOLID STATE ELECTR JI J. Solid State Electrochem. PD AUG PY 2008 VL 12 IS 7-8 BP 1031 EP 1033 DI 10.1007/s10008-007-0459-1 PG 3 WC Electrochemistry SC Electrochemistry GA 304DO UT WOS:000256090400038 ER PT J AU Alberts, WCK Noble, JM Coleman, MA AF Alberts, W. C. Kirkpatrick, II Noble, John M. Coleman, Mark A. TI Sound propagation in the vicinity of an isolated building: An experimental investigation SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID STREET CANYONS; REFLECTING BOUNDARIES; URBAN AREAS; BARRIERS; MODEL; DIFFRACTION; ENVIRONMENT; NOISE; FLOW AB Recently, the study of acoustics in urban terrain has been concerned with the propagation of sound through street canyons typical of residential areas in large cities, while sparsely built suburban and rural areas have received little attention. An isolated building's effect on propagating sound is a fundamental case of suburban acoustics and urban acoustics in general. Its study is a necessity in order to determine the processes that might be required to model the sound field in the building's vicinity, e.g., diffraction and wind effects. The work herein presents the results of an experimental effort to characterize the interaction between propagating sound and a single story, gabled-roof building typical of some North American suburban and rural areas. Recorded data are found to reasonably compare to a common diffraction model in some instances. (C) 2008 Acoustical Society of America. C1 [Alberts, W. C. Kirkpatrick, II; Noble, John M.; Coleman, Mark A.] USA, Res Lab, Attn AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Alberts, WCK (reprint author), USA, Res Lab, Attn AMSRD ARL CI ES, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kirk.alberts@arl.army.mil NR 28 TC 8 Z9 8 U1 1 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 2008 VL 124 IS 2 BP 733 EP 742 DI 10.1121/1.2945151 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 334OG UT WOS:000258230500015 PM 18681566 ER PT J AU Wilson, DK Ostashev, VE Goedecke, GH AF Wilson, D. Keith Ostashev, Vladimir E. Goedecke, George H. TI Sound-wave coherence in atmospheric turbulence with intrinsic and global intermittency SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article; Proceedings Paper CT 12th Long Range Sound Propagation Symposium CY 2006 CL New Orleans, LA ID PROBABILITY DENSITY-FUNCTIONS; BOUNDARY-LAYER; SURFACE-LAYER; VELOCITY FLUCTUATIONS; SHADOW ZONE; SCATTERING; TEMPERATURE; MODEL; PROPAGATION; SPECTRUM AB The coherence function of sound waves propagating through an intermittently turbulent atmosphere is calculated theoretically. Intermittency mechanisms due to both the turbulent energy cascade (intrinsic intermittency) and spatially uneven production (global intermittency) are modeled using ensembles of quasiwavelets (QWs), which are analogous to turbulent eddies. The intrinsic intermittency is associated with decreasing spatial density (packing fraction) of the QWs with decreasing size. Global intermittency is introduced by allowing the local strength of the turbulence, as manifested by the amplitudes of the QWs, to vary in space according to superimposed Markov processes. The resulting turbulence spectrum is then used to evaluate the coherence function of a plane sound wave undergoing line-of-sight propagation. Predictions are made by a general simulation method and by an analytical derivation valid in the limit of Gaussian fluctuations in signal phase. It is shown that the average coherence function increases as a result of both intrinsic and global intermittency. When global intermittency is very strong, signal phase fluctuations become highly non-Gaussian and the average coherence is dominated by episodes with weak turbulence. (C) 2008 Acoustical Society of America. C1 [Wilson, D. Keith] USA, Army Res & Dev Ctr, Hanover, NH 03755 USA. [Ostashev, Vladimir E.] NOAA, Earth Syst Res Lab, Boulder, CO 80303 USA. [Ostashev, Vladimir E.; Goedecke, George H.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. RP Wilson, DK (reprint author), USA, Army Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM d.keith.wilson@usace.army.mil; vladimir.ostashev@noaa.gov; ggoedeck@nmsu.edu RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 47 TC 4 Z9 4 U1 0 U2 4 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 2008 VL 124 IS 2 BP 743 EP 757 DI 10.1121/1.2945162 PG 15 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 334OG UT WOS:000258230500016 PM 18681567 ER PT J AU Phatak, SA Lovitt, A Allen, JB AF Phatak, Sandeep A. Lovitt, Andrew Allen, Jont B. TI Consonant confusions in white noise SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ARTICULATION INDEX; PERCEPTUAL FEATURES; SPEECH; RECOGNITION; LISTENERS AB The classic [MN55] confusion matrix experiment (16 consonants, white noise masker) was repeated by using computerized procedures, similar to those of Phatak and Allen (2007). ["Consonant and vowel confusions in speech-weighted noise," J. Acoust. Soc. Am. 121, 2312-2316]. The consonant scores in white noise can be categorized in three sets: low-error set {/m/, /n/}, average-error set {/p/, /t/, /k/, /s/, //, /d/, /g/, /z/, /3/}, and high-error set {/f/, /theta/, /b/, /v/, /partial derivative/}. The consonant confusions match those from MN55, except for the highly asymmetric voicing confusions of fricatives, biased in favor of voiced consonants. Masking noise cannot only reduce the recognition of a consonant, but also perceptually morph it into another consonant. There is a significant and systematic variability in the scores and confusion patterns of different utterances of the same consonant, which can be characterized as (a) confusion heterogeneity, where the competitors in the confusion groups of a consonant vary, and (b) threshold variability, where confusion threshold [i.e., signal-to-noise ratio (SNR) and score at which the confusion group is formed] varies. The average consonant error and errors for most of the individual consonants and consonant sets can be approximated as exponential functions of the articulation index (AI). An AI that is based on the peak-to-rms ratios of speech can explain the SNR differences across experiments. (C) 2008 Acoustical Society of America. C1 [Phatak, Sandeep A.; Lovitt, Andrew; Allen, Jont B.] Univ Illinois, ECE Dept, Urbana, IL 61801 USA. [Phatak, Sandeep A.; Lovitt, Andrew; Allen, Jont B.] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA. RP Phatak, SA (reprint author), USA, Audiol & Speech Ctr, Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 29 TC 36 Z9 36 U1 2 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 2008 VL 124 IS 2 BP 1220 EP 1233 DI 10.1121/1.2913251 PG 14 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 334OG UT WOS:000258230500058 PM 18681609 ER PT J AU Smith, RB Woods, BK Jensen, J Cooper, WA Doyle, JD Jiang, QF Grubisic, V AF Smith, Ronald B. Woods, Bryan K. Jensen, Jorgen Cooper, William A. Doyle, James D. Jiang, Qingfang Grubisic, Vanda TI Mountain waves entering the stratosphere SO JOURNAL OF THE ATMOSPHERIC SCIENCES LA English DT Article ID GRAVITY-WAVES; TROPICAL TROPOPAUSE; AGEOSTROPHIC WINDS; MIDDLE ATMOSPHERE; RESEARCH AIRCRAFT; MONT-BLANC; BREAKING; PROPAGATION; GENERATION; HEIGHT AB Using the National Science Foundation (NSF)-NCAR Gulfstream V and the NSF-Wyoming King Air research aircraft during the Terrain-Induced Rotor Experiment (T-REX) in March-April 2006, six cases of Sierra Nevada mountain waves were surveyed with 126 cross-mountain legs. The goal was to identify the influence of the tropopause on waves entering the stratosphere. During each flight leg, part of the variation in observed parameters was due to parameter layering, heaving up and down in the waves. Diagnosis of the combined wave-layering signal was aided with innovative use of new GPS altitude measurements. The ozone and water vapor layering correlated with layered Bernoulli function and cross-flow speed. GPS-corrected static pressure was used to compute the vertical energy flux, confirming, for the first time, the Eliassen-Palm relation between momentum and energy flux (EF =-U . MF). Kinetic (KE) and potential (PE) wave energy densities were also computed. The equipartition ratio (EQR = PE/KE) changed abruptly across the tropopause, indicating partial wave reflection. In one case (16 April 2006) systematically reversed momentum and energy fluxes were found in the stratosphere above 12 km. On a "wave property diagram," three families of waves were identified: up-and downgoing long waves (30 km) and shorter (14 km) trapped waves. For the latter two types, an explanation is proposed related to secondary generation near the tropopause and reflection or secondary generation in the lower stratosphere. C1 [Smith, Ronald B.; Woods, Bryan K.] Yale Univ, New Haven, CT 06520 USA. [Jensen, Jorgen; Cooper, William A.] NCAR UCAR, Boulder, CO USA. [Doyle, James D.] USA, Res Lab, Monterey, CA USA. [Jiang, Qingfang] UCAR, Monterey, CA USA. [Grubisic, Vanda] Univ Nevada, Desert Res Inst, Reno, NV 89506 USA. RP Smith, RB (reprint author), Yale Univ, POB 208109, New Haven, CT 06520 USA. EM ronald.smith@yale.edu RI Jensen, Jorgen/C-9211-2009 NR 37 TC 38 Z9 38 U1 2 U2 17 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0022-4928 J9 J ATMOS SCI JI J. Atmos. Sci. PD AUG PY 2008 VL 65 IS 8 BP 2543 EP 2562 DI 10.1175/2007JAS2598.1 PG 20 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 339IN UT WOS:000258571400004 ER PT J AU Lindeman, J Broutman, D Eckermann, SD Ma, J Rottman, JW Boybeyi, Z AF Lindeman, John Broutman, Dave Eckermann, Stephen D. Ma, Jun Rottman, James W. Boybeyi, Zafer TI Mesoscale model initialization of the Fourier method for mountain waves SO JOURNAL OF THE ATMOSPHERIC SCIENCES LA English DT Article ID TRAPPED LEE WAVES; GRAVITY-WAVES; STRATIFIED FLOW; MIDDLE ATMOSPHERE; DRAG; PARAMETRIZATION; OROGRAPHY; SPECTRUM AB A Fourier method is combined with a mesoscale model to simulate mountain waves. The mesoscale model describes the nonlinear low-level flow and predicts the emerging wave field above the mountain. This solution serves as the lower boundary condition for the Fourier method, which follows the waves upward to much higher altitudes and downward to the ground to examine parameterizations for the orography and the lower boundary condition. A high-drag case with a Froude number of 2/3 is presented. C1 [Lindeman, John; Boybeyi, Zafer] George Mason Univ, Coll Sci, Fairfax, VA 22030 USA. [Broutman, Dave; Ma, Jun] Computat Phys Inc, Springfield, VA USA. [Eckermann, Stephen D.] USA, Res Lab, Div Space Sci, Washington, DC 20310 USA. [Rottman, James W.] Sci Applicat Int Corp, Naval Hydrodynam Div, San Diego, CA USA. RP Lindeman, J (reprint author), George Mason Univ, Coll Sci, 4400 Univ Dr, Fairfax, VA 22030 USA. EM jlindema@gmu.edu FU National Science Foundation [ATM-0448888, ATM-0435789]; Office of Naval Research 6.1 program; NASA's Modeling, Analysis and Prediction program [NNG06HM19i]; MDA [B044-159-0300] FX This work is part of the Ph.D. thesis of JL. Funding was provided for JL and DB by the National Science Foundation under Grants ATM-0448888 and ATM-0435789; for SDE by the Office of Naval Research 6.1 program and by NASA's Modeling, Analysis and Prediction program, Grant NNG06HM19i; and for JM by MDA Contract B044-159-0300. NR 22 TC 4 Z9 4 U1 0 U2 3 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0022-4928 J9 J ATMOS SCI JI J. Atmos. Sci. PD AUG PY 2008 VL 65 IS 8 BP 2749 EP 2756 DI 10.1175/2008JAS2541.1 PG 8 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 339IN UT WOS:000258571400018 ER PT J AU Vorontsov, MA Lachinova, SL AF Vorontsov, Mikhail A. Lachinova, Svetlana L. TI Laser beam projection with adaptive array of fiber collimators. I. Basic considerations for analysis SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article AB We present a mathematical model and provide an analysis of optical beam director systems composed of adaptive arrays of fiber collimators (subapertures), referred to here as conformal optical systems. Performances of the following two system architectures are compared: A conformal-beam director with mutually incoherent output laser beams transmitted through fiber collimators (beamlets), and a corresponding coherent system whose beamlets can be coherently combined (phase locked) at a remote target plane. The effect of the major characteristics of the conformal systems on the efficiency of laser beam projection is evaluated both analytically and through numerical simulations. The characteristics considered here are the number of fiber collimators and the subaperture and conformal aperture fill factors, as well as the accuracy of beamlet pointing. (c) 2008 Optical Society of America. C1 [Vorontsov, Mikhail A.] USA, Res Lab, Intelligent Opt Lab, Comp & Informat Sci Directorate, Adelphi, MD 20783 USA. [Vorontsov, Mikhail A.; Lachinova, Svetlana L.] Univ Maryland, Syst Res Inst, Intelligent Opt Lab, College Pk, MD 20742 USA. RP Vorontsov, MA (reprint author), USA, Res Lab, Intelligent Opt Lab, Comp & Informat Sci Directorate, Adelphi, MD 20783 USA. EM mvorontsov@arl.army.mil FU U.S. Joint Technology Office [SA05-0101/SA04-0104]; U.S. Army Research Laboratory and the University of Maryland, College Park [W911NF-06-2-0009] FX The authors are grateful to Joseph Mangano and Anton Kohnle for helpful discussions and comments. This work was supported in part by the U.S. Joint Technology Office under contract SA05-0101/SA04-0104 and by Cooperative Agreement W911NF-06-2-0009 between the U.S. Army Research Laboratory and the University of Maryland, College Park. NR 24 TC 57 Z9 69 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD AUG PY 2008 VL 25 IS 8 BP 1949 EP 1959 DI 10.1364/JOSAA.25.001949 PG 11 WC Optics SC Optics GA 341ET UT WOS:000258697700014 PM 18677358 ER PT J AU Lachinova, SL Vorontsov, MA AF Lachinova, Svetlana L. Vorontsov, Mikhail A. TI Laser beam projection with adaptive array of fiber collimators. II. Analysis of atmospheric compensation efficiency SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID TURBULENCE; OPTICS AB We analyze the potential efficiency of laser beam projection onto a remote object in atmosphere with incoherent and coherent phase-locked conformal-beam director systems composed of an adaptive array of fiber collimators. Adaptive optics compensation of turbulence-induced phase aberrations in these systems is performed at each fiber collimator. Our analysis is based on a derived expression for the atmospheric-averaged value of the mean square residual phase error as well as direct numerical simulations. Operation of both conformal-beam projection systems is compared for various adaptive system configurations characterized by the number of fiber collimators, the adaptive compensation resolution, and atmospheric turbulence conditions. (c) 2008 Optical Society of America. C1 [Vorontsov, Mikhail A.] USA, Res Lab, Comp Informat Sci Directorate, Intelligent Opt Lab, Adelphi, MD 20783 USA. [Lachinova, Svetlana L.; Vorontsov, Mikhail A.] Univ Maryland, Syst Res Inst, Intelligent Opt Lab, College Pk, MD 20742 USA. RP Vorontsov, MA (reprint author), USA, Res Lab, Comp Informat Sci Directorate, Intelligent Opt Lab, Adelphi, MD 20783 USA. EM mvorontsov@arl.army.mil FU U.S. Joint Technology Office [SA05-0101/SA04-0104]; U.S. Army Research Laboratory and the University of Maryland, College Park [W911NF-06-2-0009] FX The authors are grateful to Joseph Mangano and Anton Kohnle for helpful discussions and comments. This work was supported in part by the U.S. Joint Technology Office under contract SA05-0101/SA04-0104 and by Cooperative Agreement W911NF-06-2-0009 between the U.S. Army Research Laboratory and the University of Maryland, College Park. NR 36 TC 32 Z9 40 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 EI 1520-8532 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD AUG PY 2008 VL 25 IS 8 BP 1960 EP 1973 DI 10.1364/JOSAA.25.001960 PG 14 WC Optics SC Optics GA 341ET UT WOS:000258697700015 PM 18677359 ER PT J AU Vollmerhausen, RH Driggers, RG Wilson, DL AF Vollmerhausen, Richard H. Driggers, Ronald G. Wilson, David L. TI Predicting range performance of sampled imagers by treating aliased signal as target-dependent noise SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID TEMPERATURE DIFFERENCE; SPURIOUS RESPONSE; IDENTIFICATION; RECOGNITION; CONTRAST AB This paper presents a new theory to predict the impact of sampling on target acquisition. The aliased signal that results from sampling is treated as noise. The aliased signal is different from detector noise in two ways. First, aliasing disappears as the target contrast decreases. Second, the image corruption due to aliasing gets worse with increased range. This is because sampling is constant in angle space, and targets become poorly sampled as range increases. The theory is presented, along with the results of three experiments. The match between model and experiment is excellent. (c) 2008 Optical Society of America C1 [Driggers, Ronald G.; Wilson, David L.] USA, Res Dev & Engn Command, Commun & Elect Res, Ctr Dev & Engn,Night Vis & Elect Sensors Director, Ft Belvoir, VA 22060 USA. RP Vollmerhausen, RH (reprint author), 760 Jacktown Rd, Lexington, VA 24450 USA. EM vollmerhausen@hughes.net NR 15 TC 8 Z9 11 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD AUG PY 2008 VL 25 IS 8 BP 2055 EP 2065 DI 10.1364/JOSAA.25.002055 PG 11 WC Optics SC Optics GA 341ET UT WOS:000258697700024 PM 18677368 ER PT J AU Cancio, LC AF Cancio, Leopoldo C. TI Apoptosis in cardiac myocytes during the early stage after severe burn - Comment SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material ID THERMAL-INJURY; RESUSCITATION C1 USA, Inst Surg Res, Ft Sam Houston, TX USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2008 VL 65 IS 2 BP 408 EP 408 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 337US UT WOS:000258461600034 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Titanic's last secrets: The further adventures of shadow divers John Chatterton and Richie Kohler SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 2008 VL 133 IS 13 BP 97 EP 97 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 341LB UT WOS:000258714900215 ER PT J AU Cheuvront, SN Chinevere, TD Ely, BR Kenefick, RW Goodman, DA Mcclung, JP Sawka, MN AF Cheuvront, Samuel N. Chinevere, Troy D. Ely, Brett R. Kenefick, Robert W. Goodman, Daniel A. Mcclung, James P. Sawka, Michael N. TI Serum S-100 beta response to exercise-heat strain before and after acclimation SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE blood-brain barrier; thermoregulation; heat acclimatization; hyperthermia ID BLOOD-BRAIN-BARRIER; PROLONGED EXERCISE; PERIPHERAL-BLOOD; S-100B PROTEIN; RENAL-FUNCTION; S100B PROTEIN; RELEASE; PERMEABILITY; HYPERTHERMIA; DAMAGE AB Exercise alone or in combination with environmental heat stress can elevate blood S-100 beta protein concentrations. However, the explanatory power of exercise with marked environmental heat stress on the appearance of S-100 beta is questionable. It is possible that the process of heat acclimation might afford additional insight. Purpose: Determine the S-100 beta response to moderate-intensity exercise with heat strain before and after heat acclimation. Methods: Nine healthy male volunteers completed 10 consecutive days of heat acclimation consisting of up to 100 min of treadmill walking (1.56 m.s(-1), 4% grade) in the heat (45 degrees C, 20% relative humidity). Changes in HR, rectal temperature (T-re), and sweat rate (SR) were examined to determine successful acclimation. Area under the curve (AUC) for T-re greater than 38.5 degrees C was calculated to assess cumulative hyperthermia. Blood samples were taken before and after exercise on days I and 10 and were analyzed for serum osmolality and S-100 beta concentration. Results: All subjects displayed physiological adaptations to heat acclimation including a significant (P < 0.05) reduction in final HR (161 to 145 bpm) and T-re (39.0 to 38.4 degrees C), as well as a modest (similar to 10%) increase in SR (1.10 to 1.20 L.h(-1); P = 0.09). No differences were observed in pre- to postexercise sentin S-100 beta concentrations on day 1 or 10, and no differences were observed in S-100 beta values between days 1 and 10. No significant correlations were found between S-100 beta values and any variable of interest. Conclusions: S-100 beta concentrations do not necessarily increase in response to exercise-heat strain, and no effect of heat acclimation on S-100 beta could be observed despite other quantifiable physiological adaptations. C1 [Cheuvront, Samuel N.; Chinevere, Troy D.; Ely, Brett R.; Kenefick, Robert W.; Goodman, Daniel A.; Mcclung, James P.; Sawka, Michael N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM samuel.cheuvront@na.amedd.army.mil RI McClung, James/A-1989-2009 NR 33 TC 13 Z9 14 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD AUG PY 2008 VL 40 IS 8 BP 1477 EP 1482 DI 10.1249/MSS.0b013e31816d65a5 PG 6 WC Sport Sciences SC Sport Sciences GA 329UT UT WOS:000257896800019 PM 18614943 ER PT J AU Vormelker, AH Vatamanu, OL Kecskes, L Lewandowski, JJ AF Vormelker, A. H. Vatamanu, O. L. Kecskes, L. Lewandowski, J. J. TI Effects of test temperature and loading conditions on the tensile properties of a Zr-based bulk metallic glass SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT 4th International Conference on Bulk Metallic Glasses CY MAY 01-05, 2005 CL Gatlinburg, TN ID UNDERCOOLED LIQUID-STATE; DEFORMATION-BEHAVIOR; HYDROSTATIC-PRESSURE; HOMOGENEOUS DEFORMATION; MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; AMORPHOUS ALLOY; FRACTURE; FLOW; ZR41.2TI13.8CU12.5NI10.0BE22.5 AB The effects of changes in test temperature (20 degrees C, 260 degrees C, 330 degrees C, and 380 degrees C), strain rate (10(-5) to 10(-1) s(-1)), and loading conditions (displacement control vs loading-rate control) on the tensile behavior of Zr(41.2)Ti(13.8)Cu(12.5)Ni(10)Be(22.5) (LiquidMetal 1 (LM1)), a bulk metallic glass (BMG), have been determined. Significant effects of the test temperature, strain rate, and loading condition were observed on the strength, ductility/elongation, and mechanisms of failure (shear, ductile rupture, etc.). This material exhibited extensive elongation (i.e., > 100 pct) prior to failure when tested near the glass transition temperature (T(g) approximate to 375 degrees C) at sufficiently low strain rates, while higher strain rates or lower test temperatures produced shear fracture at low elongation. The flow and fracture behavior was also significantly affected by the loading condition (i.e., displacement vs loading-rate control). The effective strain rate necessary to cause failure in shear without significant global flow was several orders of magnitude lower in loading-rate control than in displacement control. Samples exhibiting high elongation tested in displacement control gently and convexly drew to a near point (i.e., ductile rupture). Samples tested at the same temperature exhibiting high elongation in loading-rate control rapidly and concavely necked, followed by drawing to a constant diameter "wire" (i.e., ductile drawing), eventually failing by nearly pure ductile rupture. All samples that displayed significant elongation did so inhomogeneously, and were characterized by non-Newtonian global flow. C1 [Vormelker, A. H.; Vatamanu, O. L.] Case Western Reserve Univ, Dept Mat Sci & Engn, Marine Mech Corp, Cleveland, OH 44117 USA. [Vatamanu, O. L.] Powdermet Inc, Euclid, OH 44117 USA. [Lewandowski, J. J.] Case Western Reserve Univ, Dept Mat Sci & Engn, Cleveland, OH 44106 USA. [Kecskes, L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Vormelker, AH (reprint author), Case Western Reserve Univ, Dept Mat Sci & Engn, Marine Mech Corp, 24703 Euclid Ave, Cleveland, OH 44117 USA. EM jjl3@case.edu RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 50 TC 16 Z9 16 U1 1 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD AUG PY 2008 VL 39A IS 8 BP 1922 EP 1934 DI 10.1007/s11661-007-9410-4 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 315NL UT WOS:000256886600023 ER PT J AU Brooks, MS Laditka, SB Laditka, JN AF Brooks, Matthew S. Laditka, Sarah B. Laditka, James N. TI Evidence of greater health care needs among older veterans of the Vietnam War SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; REPORTED PHYSICAL HEALTH; MILITARY SERVICE; COMBAT EXPOSURE; MENTAL-HEALTH; SYMPTOMS; ASSOCIATION; MORTALITY; DISEASE; LIFE AB This study examined self-rated health, impairments in activities of daily living, and treatment for eight health conditions among Vietnam War-era veterans, comparing those who served in Vietnam with those who served elsewhere. Data were from the nationally representative 2001 National Survey of Veterans (N = 7,907; 3,923 veterans served in Vietnam). Age-stratified (<60 years versus >= 60 years) analyses included multivariate logistic regression. In adjusted analyses, among those <60 years of age, those who served in Vietnam had notably poorer self-rated health and higher stroke risk (odds ratio, 1.51; 95% confidence interval, 1.48-1.53); odds of most other conditions were lower. Among those >= 60 years of age, those who served in Vietnam had poorer self-rated health, higher cancer risk (odds ratio, 1.33; 95% confidence interval, 1.32-1.35), and more treatment for hypertension, lung conditions, stroke, and hearing loss. Results suggest greater resource use among older veterans who served in Vietnam. Clinicians and the Department of Veterans Affairs should especially note their substantially higher cancer risk. C1 [Brooks, Matthew S.] USA, Baylor Grad Program Hlth & Business Adm, Ft Sam Houston, TX 78234 USA. [Laditka, Sarah B.; Laditka, James N.] Univ N Carolina, Dept Publ Hlth Sci, Charlotte, NC 28223 USA. RP Brooks, MS (reprint author), USA, Baylor Grad Program Hlth & Business Adm, Ft Sam Houston, TX 78234 USA. NR 29 TC 6 Z9 7 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2008 VL 173 IS 8 BP 715 EP 720 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 337DS UT WOS:000258416300001 PM 18751585 ER PT J AU Petinaux, B AF Petinaux, Bruno TI The financial impact of deployments on reserve health care providers SO MILITARY MEDICINE LA English DT Article AB This study retrospectively surveyed the financial impact of deployments on 17 U.S. Army Reserve health care providers. Due to multiple mobilizations, 29 separate deployments were reported. The deployments, mostly between 2001 and 2005, typically lasted 3 months during which 86% reported no civilian income and 76% reported no civilian benefits. Solo practice providers reported the greatest financial losses due to continuing financial responsibility related to their civilian practice despite being deployed. Overall, 2 deployments did not change, 9 increased, and 16 decreased the medical officer's income. Two were not reported. In this small retrospective convenience sample study, solo practice U.S. Army Reserve health care providers were found to be at highest risk of financial losses during military deployments. This being said, no price can be put on the privilege of serving our men and women in uniform. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Petinaux, B (reprint author), Walter Reed Army Med Ctr, 2290th USAH, Washington, DC 20307 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2008 VL 173 IS 8 BP 729 EP 733 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 337DS UT WOS:000258416300003 PM 18751587 ER PT J AU Drifmeyer, E Oh, R AF Drifmeyer, Erin Oh, Robert TI Morning report in military family medicine residencies SO MILITARY MEDICINE LA English DT Article ID FORMAT AB Morning report is a standard component of residency training; however, little is written about this conference in family medicine. We emailed a survey to all 17 military family medicine residency directors. Descriptive statistics were used to calculate means and SDs. Twelve of 17 programs responded. All conducted morning report and all agreed that the main purpose of morning report is education. Its educational value ranked highly (mean, 4.2; SD = 0.78; with 1 = minimal educational value and 5 = very important educational value). Programs reported morning report being held four to five times a week (66%) for 30 minutes (92%) and using preprepared cases (75%) half the time or more. Most (75%) reported having no written goals and objectives; 77% did not track educational outcomes. Although military residencies appear to regard morning report as an important educational venue, most do not have goals or objectives nor formally evaluate effectiveness. C1 [Oh, Robert] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI USA. RP Drifmeyer, E (reprint author), RSS, Med Troop, 3rd ACR, APO, AE 09334 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD AUG PY 2008 VL 173 IS 8 BP 765 EP 768 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 337DS UT WOS:000258416300010 PM 18751594 ER PT J AU Barr, KR Lindsay, DL Athrey, G Lance, RF Hayden, TJ Tweddale, SA Leberg, PL AF Barr, Kelly R. Lindsay, Denise L. Athrey, Giri Lance, Richard F. Hayden, Timothy J. Tweddale, Scott A. Leberg, Paul L. TI Population structure in an endangered songbird: maintenance of genetic differentiation despite high vagility and significant population recovery SO MOLECULAR ECOLOGY LA English DT Article DE black-capped vireos; endangered species; gene flow; microsatellites; recovering populations ID BLACK-CAPPED VIREO; ALLELE FREQUENCY DATA; PARTIAL MANTEL TESTS; MICROSATELLITE DNA; DEMOGRAPHIC BOTTLENECKS; EMPIRICAL-EVALUATION; UNITED-STATES; F-STATISTICS; FLOW; CONSEQUENCES AB Black-capped vireos (Vireo atricapilla), an endangered, migratory species dependent upon early successional habitat, have experienced significant recovery since its protection. In light of its vagility and known increase in population size and range, limited genetic differentiation would be expected in the species. Using 15 microsatellite loci and an extensive sampling regime, we detected significant overall genetic differentiation (F-ST = 0.021) and high interpopulation differentiation compared to other migratory birds. Although proximate sites (separated by < 20 km) tended to be genetically similar, there was no apparent association of either geographical distance or landscape attributes with differentiation between sites. Evidence of a population bottleneck was also detected in a site located near other large concentrations of birds. Although black-capped vireos are capable of large-scale movements and the population has experienced a recent expansion, dispersal appears too insufficient to eliminate the genetic differentiation resulting from restricted colonization of ephemeral habitats. C1 [Barr, Kelly R.; Athrey, Giri; Leberg, Paul L.] Univ Louisiana, Dept Biol, Lafayette, LA 70504 USA. [Lindsay, Denise L.; Lance, Richard F.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Hayden, Timothy J.; Tweddale, Scott A.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Barr, KR (reprint author), Univ Louisiana, Dept Biol, Lafayette, LA 70504 USA. EM kellybarr@gmail.com RI Athrey, Giri/C-2511-2008; Athrey, Giridhar/H-4077-2011 OI Athrey, Giridhar/0000-0002-7396-5490 NR 70 TC 32 Z9 32 U1 1 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0962-1083 J9 MOL ECOL JI Mol. Ecol. PD AUG PY 2008 VL 17 IS 16 BP 3628 EP 3639 DI 10.1111/j.1365-294X.2008.03868.x PG 12 WC Biochemistry & Molecular Biology; Ecology; Evolutionary Biology SC Biochemistry & Molecular Biology; Environmental Sciences & Ecology; Evolutionary Biology GA 334KK UT WOS:000258220500005 PM 18643883 ER PT J AU Slawski, TM Veraldi, FM Pescitelli, SM Pauers, MJ AF Slawski, Thomas M. Veraldi, Francis M. Pescitelli, Stephen M. Pauers, Michael J. TI Effects of tributary spatial position, urbanization, and multiple low-head dams on warmwater fish community structure in a Midwestern stream SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID ASSEMBLAGE STRUCTURE; WISCONSIN STREAMS; BIOTIC INTEGRITY; UPSTREAM; HABITAT; RIVER; IMPOUNDMENT; PATTERNS; QUALITY; MACROINVERTEBRATES AB A survey of stream fish communities was conducted in the upper Des Plaines River watershed in Illinois and Wisconsin to determine the distribution of fish species and to evaluate the effects of tributary spatial position, urbanization, and multiple low-head dams on fish species diversity and species composition. Forty-eight sites upstream of Salt Creek in Illinois to the headwaters in Wisconsin were surveyed between 2002 and 2004. We found that fish species diversity decreased as agricultural land was replaced by urban land. In addition, tributary position within the drainage network caused significant differences in fish species diversity; specifically, We found significantly less fish species diversity in main-stem tributary streams located lower in the drainage network than in similarly sized streams located in the headwaters of the drainage area. Fish species composition. determined by multivariate principal components analysis, also showed significant differences among stream position within the drainage network. Increases in urbanization did not have a significant effect on fish species diversity within undammed tributary sites, but it did have a strong influence on fish species composition. Hence. as urbanization increased in these undammed tributaries, the fish species composition changed from coolwater-riverine specialist to warmwater-riverine generalist assemblages. In contrast, for tributary streams with low-head dams, the presence of dams had a greater effect on fish species composition than urbanization. In addition, the presence of multiple low-head dams on the main stem had a cumulative detrimental effect on fish species diversity, which decreased along an upstream-to-downstream gradient. Consequently, it is important to consider tributary spatial position within the drainage network, the amount of urbanization, and the number and locations of darns when characterizing the structure of warmwater fish communities. especially in relation to the development of restoration plans in highly urbanized or urbanizing watersheds. C1 [Slawski, Thomas M.] SE Wisconsin Reg Planning Commiss, Waukesha, WI 53187 USA. [Veraldi, Francis M.] USA, Corps Engineers, Chicago, IL 60606 USA. [Pescitelli, Stephen M.] Illinois Dept Nat Resources, Div Fisheries, Plano, IL 60545 USA. [Pauers, Michael J.] Med Coll Wisconsin, Dept Ophthalmol, Milwaukee, WI 53226 USA. RP Slawski, TM (reprint author), SE Wisconsin Reg Planning Commiss, POB 1607, Waukesha, WI 53187 USA. EM tslawski@sewrpc.org OI Pauers, Michael/0000-0003-0748-1241 FU U.S. Army Corps of Engineers FX We thank the U.S. Army Corps of Engineers for funding this project. We thank Jeffrey Thornton and four anonymous reviewers for their critical review and discussion of ideas that have greatly contributed to the completion of this manuscript. We also thank J. D. Ennis and John Wethington for aid in GIS applications. Finally we thank Dan Treloar, Kimberly Fisher, Catherine Starr, Eugene Fleming, and Robert Rung for aid in fish collecting and Philip Willink and Jonathan Armbruster for aid in fish identification. NR 53 TC 14 Z9 14 U1 5 U2 40 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD AUG PY 2008 VL 28 IS 4 BP 1020 EP 1035 DI 10.1577/M06-186.1 PG 16 WC Fisheries SC Fisheries GA 356JN UT WOS:000259774600005 ER PT J AU Yauger, BJ Gorden, P Park, J Cochran, E Stratton, P AF Yauger, Belinda J. Gorden, Phillip Park, Jean Cochran, Elaine Stratton, Pamela TI Effect of depot medroxyprogesterone acetate on glucose tolerance in generalized lipodystrophy SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID INSULIN AB BACKGROUND: Lipodystrophy is a rare condition causing severe insulin resistance and frank diabetes. Depot medroxyprogesterone acetate (DMPA), a commonly used contraceptive, may worsen glucose tolerance in diabetics and those with lipodystrophy. CASE: A young woman with generalized lipodystrophy, who previously required greater than 1,000 units of insulin daily, had a normal hemoglobin A1c on leptin and metformin only. After an injection of DMPA, she developed severe hyperglycemia. Her levels returned to near normal only with extremely high doses of insulin (up to 1,700 units/d) and increased doses of leptin and metformin. CONCLUSION: Progestin-only contraceptives may detrimentally affect glucose tolerance, particularly in patients with lipodystrophy, a cause of severe insulin resistance and leptin deficiency. One DMPA injection appeared to profoundly alter glucose metabolism in this patient with frank diabetes resulting from lipodystrophy. The effect of progestin-only contraceptives on glucose tolerance should be monitored closely in any diabetic patient. C1 [Yauger, Belinda J.] NICHD, RBMB, NIH, CRC, Bethesda, MD 20892 USA. NIH, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Div Reprod Endocrinol & Infertil, Washington, DC 20307 USA. NIDDK, Clin Endocrinol Branch, NIH, Bethesda, MD USA. RP Yauger, BJ (reprint author), NICHD, RBMB, NIH, CRC, 10 Ctr Dr,Bldg 10,1-3140, Bethesda, MD 20892 USA. EM yaugerbe@mail.nih.gov FU Intramural NIH HHS [Z99 DK999999] NR 8 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD AUG PY 2008 VL 112 IS 2 BP 445 EP 447 DI 10.1097/AOG.0b013e3181662d17 PN 2 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 334QV UT WOS:000258237200012 PM 18669758 ER PT J AU Zheng, JH Mase, H Demirbilek, Z Lin, LH AF Zheng, Jinhai Mase, Hajime Demirbilek, Zeki Lin, Lihwa TI Implementation and evaluation of alternative wave breaking formulas in a coastal spectral wave model SO OCEAN ENGINEERING LA English DT Article DE numerical models; random waves; currents; wave action; breaking waves; energy dissipation ID ENERGY-BALANCE-EQUATION; BOUSSINESQ EQUATIONS; TRANSFORMATION; SIMULATION AB This paper describes methods and results of research for incc rporating four different parameterized wave breaking and dissipation formulas in a coastal wave pred ction model. Two formulations assume the breaking energy dissipation to be limited by the Rayleig i distribution, whereas the other two represent the breaking wave energy by a bore model. These 1501, r formulations have been implemented in WABED, a directional spectral wave model based on th - wave action balance equation with diffraction, reflection, and wave-current interaction capabiliti !s. Four parameterized wave breaking formulations are evaluated in the present study using two hig i-quality laboratory data sets. The first data set is from a wave transformation experiment at an ide, lized inlet entrance, representing four incident irregular waves in a slack tide and two steady-state ebt current conditions. The second data set is from a laboratory study of wave propagation over a compley bathymetry with strong wave-induced currents. Numerical simulation results show that with a prope breaking formulation the wave model can reproduce laboratory data for waves propagating over idea ized or complicated bathymetries with ambient currents. The extended Goda wave breaking for nulation with a truncated Rayleigh distribution, and the Battjes and Janssen formulation with a bc re model produced the best agreement between model and data. (c) 2008 Published by Elsevier Ltd. C1 [Zheng, Jinhai] Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, Nanjing 210098, Jiangsu, Peoples R China. [Mase, Hajime] Kyoto Univ, Disaster Prevent Res Inst, Kyoto 6110011, Japan. [Demirbilek, Zeki; Lin, Lihwa] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. RP Zheng, JH (reprint author), Hohai Univ, State Key Lab Hydrol Water Resources & Hydraul En, Nanjing 210098, Jiangsu, Peoples R China. EM jhzheng@hhu.edu.cn NR 39 TC 26 Z9 29 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD AUG PY 2008 VL 35 IS 11-12 BP 1090 EP 1101 DI 10.1016/j.oceaneng.2008.05.001 PG 12 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 334QX UT WOS:000258237400004 ER PT J AU Cantey, TM Ballard, G Gregory, DA AF Cantey, Thomas M. Ballard, Gary Gregory, Don A. TI Application of type IIW-quantum-well diode lasers for high-dynamic-temperature-range infrared scene projection SO OPTICAL ENGINEERING LA English DT Article DE infrared; scene projection; simulation; apparent temperature; mid-infrared diode lasers ID W-DIODE; TECHNOLOGY AB Currently, no infrared scene projector technology has the ability to simulate the real-world, high-dynamic-range temperatures encountered by modern infrared imagers. This paper presents the application of type II W-quantum-well diode lasers used in a high-radiance mid-infrared-emitting object plane in an effort to develop the first truly high-dynamic-range infrared scene projector. The observed dynamic-range capability simulates 250 K apparent background temperature to 1100 K maximum apparent temperature for inband mid-wave 3 to 5 mu m radiance. In the presented research a linear array of high-power continuous-wave mid-infrared diode lasers and a high-speed optical polygon scanner were used to produce two-dimensional projected images. The ability to simulate high apparent temperatures was the direct result of luminescent infrared radiance emitted by the diode lasers. The simulation of the low background apparent temperatures was obtained by enclosing the entire projector system in an environmental chamber operating at 232 K. The apparent temperature of the infrared scene projector was calculated analytically and compared with the measured results. Sample imagery from the high-dynamic-range infrared scene projector is also given. (C) 2008 Society of Photo-Optical Instrumentation Engineers. C1 [Cantey, Thomas M.] Opt Sci Corp, Huntsville, AL 35808 USA. [Ballard, Gary] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL USA. [Gregory, Don A.] Univ Alabama, Dept Phys, Huntsville, AL 35899 USA. RP Cantey, TM (reprint author), Opt Sci Corp, 6767 Old Madison Pike Ste 650, Huntsville, AL 35808 USA. FU U. S. Army Aviation and Missile Research, Development, and Engineering Center (AMRDEC) FX This research was funded by a Small Business Innovative Research grant awarded by the U. S. Army Aviation and Missile Research, Development, and Engineering Center (AMRDEC). We would like to thank Danny Saylor and Mark Bowden for their help in developing key software tools, Charles Naumann and Sean McCall for excellent electrical engineering design and programming of the custom laser driver electronics and amplifiers, and Brian Robinson and Shawn DeHart for their optical and optomechanical design. NR 12 TC 5 Z9 5 U1 0 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD AUG PY 2008 VL 47 IS 8 AR 086401 DI 10.1117/1.2968247 PG 6 WC Optics SC Optics GA 357SB UT WOS:000259865500023 ER PT J AU Huppmann, MV Monson, M AF Huppmann, Michael V. Monson, Matthew TI Allergic bronchopulmonary aspergillosis: a unique presentation in a pediatric patient SO PEDIATRIC RADIOLOGY LA English DT Article DE ABPA; aspergillosis; consolidation; child ID ASTHMATIC-PATIENTS; TOMOGRAPHY; SPECTRUM; LUNG AB Infection by the Aspergillus species of fungus can result in a variety of clinically and radiographically unique pulmonary diseases. The specific disease manifested is most dependent upon the immunocompetency of the infected individual. Allergic bronchopulmonary aspergillosis (ABPA) is most commonly seen in patients with asthma and cystic fibrosis. Since its original description in 1952, much has been published describing the radiographic manifestations of this disease. In this article, we present the unusual case of a 13-year-old whose initial radiographic presentation was that of a dense lobar consolidation. Additionally, we highlight the contributory role of the radiologist in guiding the appropriate clinical work-up and treatment of this disease. C1 [Huppmann, Michael V.; Monson, Matthew] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Monson, M (reprint author), Walter Reed Army Med Ctr, Dept Radiol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Matthew.monson@amedd.army.mil NR 8 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD AUG PY 2008 VL 38 IS 8 BP 879 EP 883 DI 10.1007/s00247-008-0824-y PG 5 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA 325ND UT WOS:000257594700009 PM 18504569 ER PT J AU Waibel, KH AF Waibel, Kirk H. TI Anaphylaxis SO PEDIATRICS IN REVIEW LA English DT Review ID HYPERSENSITIVITY; ADOLESCENTS; URTICARIA; CHILDREN; RISK C1 Brooke Army Med Ctr, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA. RP Waibel, KH (reprint author), Brooke Army Med Ctr, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA. NR 14 TC 1 Z9 3 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0191-9601 J9 PEDIATR REV JI Pediatr. Rev. PD AUG PY 2008 VL 29 IS 8 BP 255 EP 263 DI 10.1542/pir.29-8-255 PG 9 WC Pediatrics SC Pediatrics GA 350KZ UT WOS:000259352600001 PM 18676577 ER PT J AU Coster, TS Fram, D DuMouchel, W Szarfman, A Dobardzic, A Xie, S AF Coster, Trinka S. Fram, David DuMouchel, William Szarfman, Ana Dobardzic, Azra Xie, Suji TI Empirical Bayesian data mining for discovering safety signals in military electronic health records SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY LA English DT Meeting Abstract C1 [Coster, Trinka S.; Dobardzic, Azra; Xie, Suji] USA, Off Surg Gen, Hlth Policy & Serv, Falls Church, VA USA. [Fram, David; DuMouchel, William] Lincoln Technol, Phase Forward, Waltham, MA USA. [Szarfman, Ana] US FDA, Ctr Drug Evaluat & Res, Div Cardiovasc & Renal Prod, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1053-8569 J9 PHARMACOEPIDEM DR S JI Pharmacoepidemiol. Drug Saf. PD AUG PY 2008 VL 17 SU 1 MA 396 BP S174 EP S174 PG 1 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA 337FE UT WOS:000258420100396 ER PT J AU Izurieta, HS Tobler, SK Garman, PM Hua, W Haber, P Iskander, J Braun, MM Ball, R AF Izurieta, Hector S. Tobler, Steven K. Garman, Patrick M. Hua, Wei Haber, Penina Iskander, John Braun, M. Miles Ball, Robert TI Anaphylaxis after measles, mumps and rubella (MMR) vaccine during 2006-7 in the US SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY LA English DT Meeting Abstract C1 [Izurieta, Hector S.; Hua, Wei; Braun, M. Miles; Ball, Robert] US FDA, Rockville, MD 20857 USA. [Tobler, Steven K.] US Army Med Surveillance Activ, Silver Spring, MD USA. [Garman, Patrick M.] US Mil Vaccinat Agcy, Falls Church, VA USA. [Haber, Penina; Iskander, John] CDC, Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1053-8569 J9 PHARMACOEPIDEM DR S JI Pharmacoepidemiol. Drug Saf. PD AUG PY 2008 VL 17 SU 1 MA 258 BP S113 EP S114 PG 2 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy GA 337FE UT WOS:000258420100259 ER PT J AU Rogers, J Schoepp, RJ Schroder, O Clements, TL Holland, TF Li, JQ Li, J Lewis, LM Dirmeier, RP Frey, GJ Tan, X Wong, K Woodnutt, G Keller, M Reed, DS Kimmel, BE Tozer, EC AF Rogers, J. Schoepp, R. J. Schroeder, O. Clements, T. L. Holland, T. F. Li, J. Q. Li, J. Lewis, L. M. Dirmeier, R. P. Frey, G. J. Tan, X. Wong, K. Woodnutt, G. Keller, M. Reed, D. S. Kimmel, B. E. Tozer, E. C. TI Rapid discovery and optimization of therapeutic antibodies against emerging infectious diseases SO PROTEIN ENGINEERING DESIGN & SELECTION LA English DT Article DE antibody discovery; humanized; optimized; SARS-CoV ID ACUTE RESPIRATORY SYNDROME; HUMAN MONOCLONAL-ANTIBODY; AVIAN INFLUENZA; GLYCOPROTEIN-B; HUMANIZATION; EPITOPE; IMMUNOPROPHYLAXIS; CYTOMEGALOVIRUS; FRAGMENTS; VARIANTS AB Using a comprehensive set of discovery and optimization tools, antibodies were produced with the ability to neutralize SARS coronavirus (SARS-CoV) infection in Vero E6 cells and in animal models. These anti-SARS antibodies were discovered using a novel DNA display method, which can identify new antibodies within days. Once neutralizing antibodies were identified, a comprehensive and effective means of converting the mouse sequences to human frameworks was accomplished using HuFR (TM) (human framework reassembly) technology. The best variant (61G4) from this screen showed a 3.5-4-fold improvement in neutralization of SARS-CoV infection in vitro. Finally, using a complete site-saturation mutagenesis methodology focused on the CDR (complementarity determining regions), a single point mutation (51E7) was identified that improved the 80% plaque reduction neutralization of the virus by greater than 8-fold. These discovery and evolution strategies can be applied to any emerging pathogen or toxin where a causative agent is known. C1 [Schoepp, R. J.; Clements, T. L.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Reed, D. S.] USA, Med Res Inst Infect Dis, Dept Anim Studies, Ft Detrick, MD 21702 USA. EM eileen.tozer@yahoo.com RI Keller, Martin/C-4416-2012; OI Reed, Douglas/0000-0003-0076-9023 FU NIAID NIH HHS [U01AI61 419-01] NR 27 TC 4 Z9 4 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1741-0126 J9 PROTEIN ENG DES SEL JI Protein Eng. Des. Sel. PD AUG PY 2008 VL 21 IS 8 BP 495 EP 505 DI 10.1093/protein/gzn027 PG 11 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 328HQ UT WOS:000257789400003 PM 18480090 ER PT J AU Rawat, R Ahmed, SA Swaminathan, S AF Rawat, Richa Ahmed, S. Ashraf Swaminathan, Subramanyam TI High level expression of the light chain of botulinum neurotoxin serotype C1 and an efficient HPLC assay to monitor its proteolytic activity SO PROTEIN EXPRESSION AND PURIFICATION LA English DT Article DE botulinum neurotoxin; cloning; catalytic activity; substrate peptide; type C1 ID SUBSTRATE-SPECIFICITY; STRUCTURAL-ANALYSIS; A NEUROTOXIN; SNARE MOTIF; SNAP-25; PROTEIN; CLEAVAGE; TETANUS; RELEASE; INTACT AB Botulinum neurotoxins (serotypes BoNT/A-BoNT/G) induce botulism, a disease leading to flaccid paralysis. These serotypes are highly specific in their proteolytic cleavage of SNAP-25 (synaptosomal-associated protein of 25 kDa), VAMP (vesicle associated membrane protein) or syntaxin. The catalytic domain (light chain, LC) of the neurotoxin has a Zn2+ dependent endopeptidase activity. In order to design drugs and inhibitors against these toxins, high level overexpression and characterization of LC of BoNTs along with the development of assays to monitor their proteolytic activity becomes important. Using the auto-induction method, we attained a high level expression of BoNT/C1(1-430) yielding more than 30 mg protein per 500 ml culture. We also developed an efficient assay to measure the activity of serotype C1 based on a HPLC method. SNAP-25 with varying peptide length has been reported in literature as substrates for BoNT/C1 proteolysis signifying the importance of remote exosites in BoNT/C1 required for activity. Here, we show that a 17-mer peptide corresponding to residues 187-203 of SNAP-25, which has earlier been shown to be a substrate for BoNT/A, can be used as a substrate for quantifying the activity of BoNT/C1 (1-430). There was no pH dependence for the proteolysis, however the presence of dithiothreitol is essential for the reaction. Although the 17-mer substrate bound 110-fold less tightly to BoNT/C1(1-430) than SNAP-25, the optimal assay conditions facilitated an increase in the catalytic efficiency of the enzyme by about 5-fold. (c) 2008 Elsevier Inc. All rights reserved. C1 [Rawat, Richa; Swaminathan, Subramanyam] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. [Ahmed, S. Ashraf] USA, Med Res Inst Infect Dis, Dept Mol Biol, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Swaminathan, S (reprint author), Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. EM swami@bnl.gov NR 28 TC 8 Z9 8 U1 1 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1046-5928 J9 PROTEIN EXPRES PURIF JI Protein Expr. Purif. PD AUG PY 2008 VL 60 IS 2 BP 165 EP 169 DI 10.1016/j.pep.2008.03.010 PG 5 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 331MO UT WOS:000258016500011 PM 18482846 ER PT J AU Croll, SM Winkley, JV Bleckner, LL Buckenmaier, CC AF Croll, Scott M. Winkley, James V. Bleckner, Lisa L. Buckenmaier, Chester C., III TI Local anesthetics for regional anesthesia: An update SO SALUD I CIENCIA LA Spanish DT Review DE local anesthetics; regional anesthesia; local anesthetic toxicity ID TRANSIENT NEUROLOGIC SYMPTOMS; SCIATIC-NERVE BLOCK; BRACHIAL-PLEXUS ANESTHESIA; SAME-DAY RECOVERY; GENERAL-ANESTHESIA; SPINAL-ANESTHESIA; PERIPHERAL-NERVE; LUMBAR PLEXUS; SUCCESSFUL RESUSCITATION; LIPID EMULSION AB Regional anesthesia in the 21(st) century, specifically peripheral nerve blocks (PNBs) and continuous peripheral nerve blocks (CPNBs), continues to enjoy unparalleled popularity. Despite this resurgence in popularity, the search for a new, longer-acting local anesthetic (LA) for injection with an improved safety profile remains an elusive and distant goal. A paucity of new local anesthetics has been developed for clinical use since the early 1970's. Efforts to Improve the efficacy, duration, and safety of injected LAs include drug additives to LAs and new needle localization technology. Any cogent discussion of the common LAs used with regional anesthesia must include a thorough summary of LA toxicity to include prevention, detection, and treatment. A specific focus on the recent emergence of Intralipid as a treatment for local anesthetic-induced cardiac toxicity will ensue. This LA review will examine basic pharmacology, explore current trends in regional anesthesia practice, and describe recent developments in the clinical use of LA and additives. C1 [Croll, Scott M.] Walter Reed Army Med Ctr, Dept Anesthesiol, Army Reg Anesthesia & Pain Management Initiat, Washington, DC 20307 USA. [Winkley, James V.] Moore Reg Hosp, Pinehurst, NC USA. RP Croll, SM (reprint author), Walter Reed Army Med Ctr, Dept Anesthesiol, Army Reg Anesthesia & Pain Management Initiat, Washington, DC 20307 USA. EM scott.croll@na.amedd.army.mil NR 79 TC 0 Z9 0 U1 0 U2 1 PU SOC IBEROAMERICANA INFORMACION CIENTIFICA-S I I C PI BUENOS AIRES PA AVE BELGRANO 430-C1092AAR, BUENOS AIRES, 00000, ARGENTINA SN 1667-8982 J9 SALUD CIENC JI Salud Cienc. PD AUG PY 2008 VL 16 IS 3 BP 286 EP 291 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 407EI UT WOS:000263346000008 ER PT J AU Garcia, MA Losurdo, M Wolter, SD Lampert, WV Bonaventura, J Bruno, G Yi, C Brown, AS AF Garcia, Michael A. Losurdo, M. Wolter, S. D. Lampert, W. V. Bonaventura, J. Bruno, G. Yi, C. Brown, A. S. TI Comparison of Functionalized III-V Semiconductor Response for Nitric Oxide SO SENSOR LETTERS LA English DT Article; Proceedings Paper CT Symposium on Functional Organic and Inorganic Materials for Micro and Nano Bio-Sensing Systems held at the 2007 EMRS Spring Meeting CY MAY 28-JUN 01, 2007 CL Strasbourg, FRANCE SP European Mat Res Soc DE Nitric Oxide; InAs; InP; GaN; Functionalize; Chemical Sensor ID FIELD-EFFECT TRANSISTORS; ACCUMULATION LAYER; INAS SURFACES; ALGAN/GAN; GAAS; IRON; GAN; HETEROSTRUCTURES; PHOTOEMISSION; IONIZATION AB Several III-V materials systems, consisting of InAs, InP, and GaN, were chemically functionalized, characterized, and evaluated for Nitric Oxide (NO) sensor research. The hemin porphyrin has been a particularly successful NO detection functional group for carbon-based material systems for sensors. The unique sensing modalities inherent in an InAs surface accumulation layer and the AlGaN/GaN surface polarization charge coupling motivated enhanced chemical sensor exploration. NO's diverse roles in defense, biological, and environmental fields create interest in the development of responsive and selective solid state sensors. In a controlled gaseous environment, functionalized and pre-functionalized III-V semiconductor materials were probed for changes in resistivity during exposure to varying concentrations of NO, NO2, O-2 and Ar. X-ray photoelectron spectroscopy was used to characterize sample functionalization and analyte influences on the valence band maxima in order to better understand the charge transduction mechanisms. The results of the trials were compared and analyzed for optimization and materials recommendations. C1 [Garcia, Michael A.; Wolter, S. D.; Yi, C.; Brown, A. S.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27709 USA. [Losurdo, M.; Bruno, G.] IMIP CNR, Inst Inorgan Methodologies & Plasmas, I-70126 Bari, Italy. [Losurdo, M.; Bruno, G.] INSTM, I-70126 Bari, Italy. [Lampert, W. V.] US Army, Res Off, Res Triangle Pk, NC 27709 USA. [Bonaventura, J.] Duke Univ, Med Ctr, Nicholas Sch Environm, Durham, NC 27710 USA. RP Garcia, MA (reprint author), Duke Univ, Dept Elect & Comp Engn, Durham, NC 27709 USA. EM mag18@duke.edu OI LOSURDO, MARIA/0000-0002-8008-5192; BRUNO, GIOVANNI/0000-0003-3116-1176 NR 57 TC 7 Z9 7 U1 1 U2 10 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1546-198X J9 SENSOR LETT JI Sens. Lett. PD AUG PY 2008 VL 6 IS 4 BP 627 EP 634 DI 10.1166/sl.2008.448 PG 8 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation; Physics, Applied SC Chemistry; Electrochemistry; Instruments & Instrumentation; Physics GA 373HU UT WOS:000260963500027 ER PT J AU Nevin, RL Shiliping, EE Frick, KD Gaydos, JC Gaydos, CA AF Nevin, Remington L. Shiliping, Eric E. Frick, Kevin D. Gaydos, Joel C. Gaydos, Charlotte A. TI Cost and effectiveness of Chlamydia screening among male military recruits: Markov modeling of complications averted through notification of prior female partners SO SEXUALLY TRANSMITTED DISEASES LA English DT Article; Proceedings Paper CT 11th International Symposium on Human Chlamydial Infections CY JUN 18-23, 2006 CL Niagara Falls, CANADA ID PELVIC-INFLAMMATORY-DISEASE; SEXUALLY-TRANSMITTED-DISEASE; ARMY-RECRUITS; UNITED-STATES; TRACHOMATIS-INFECTIONS; EMERGENCY-DEPARTMENT; YOUNG MEN; WOMEN; PREVALENCE; PROGRAM AB Background: Despite rising rates of female screening, a high economic burden remains associated with Chlamydia infection from high rates of undetected asymptomatic disease and its associated sequelae of pelvic inflammatory disease (PID) and chronic pelvic pain (CP). Males comprise the majority of US military recruits and represent an ideal population in which to achieve identification and interruption of sexually transmitted infection among infected partners through mass tandem screening. Methods: We developed a static decision tree incorporating a calibrated Markov model to predict the differences in healthcare payer direct healthcare costs, cases of PID and CP averted among female partners of male recruits through implementation of either selective (aged 24 and younger) or universal recruit screening policies incorporating partner notification. Results: A policy of selective male screening added $10.30 in direct costs per recruit, whereas universal male screening added an additional $1.60. A policy of selective male screening yielded an incremental cost-effectiveness ratio of $3.7K per case of PID averted, and $7.3K per case of CP averted, whereas universal screening yielded an incremental cost-effectiveness ratio of $8.2K per additional case of PID and $16.4K per additional case of CP averted beyond selective screening. Neither policy was dominant, and results were qualitatively robust to single-variable and probabilistic sensitivity analysis. Conclusions: In consonance with other studies of mass tandem screening, we found both selective and universal male recruit screening cost-effective as compared with other interventions. Our results argue in favor of universal screening of male recruits for Chlamydia infection, linked to partner notification. C1 [Nevin, Remington L.] USA, Med Surveillance Act, Silver Spring, MD 20910 USA. [Shiliping, Eric E.] Ireland Army Community Hosp, Ft Knox, KY USA. [Frick, Kevin D.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA. [Gaydos, Joel C.] Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD USA. [Gaydos, Charlotte A.] Johns Hopkins Med Inst, Baltimore, MD 21205 USA. RP Nevin, RL (reprint author), USA, Med Surveillance Act, 2900 Linden Lane,Suite 200, Silver Spring, MD 20910 USA. EM remington.nevin@us.army.mil RI Gaydos, Charlotte/E-9937-2010; Valle, Ruben/A-7512-2013; OI Nevin, Remington/0000-0002-0534-1889 NR 40 TC 7 Z9 7 U1 2 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD AUG PY 2008 VL 35 IS 8 BP 705 EP 713 DI 10.1097/OLQ.0b013e31816d1f55 PG 9 WC Infectious Diseases SC Infectious Diseases GA 331KE UT WOS:000258010300001 PM 18461015 ER PT J AU Chang, Y Hua, YB Xia, XG Sadler, BM AF Chang, Yu Hua, Yingbo Xia, Xiang-Gen Sadler, Brian M. TI An insight into space-time block codes using Hurwitz-Radon families of matrices SO SIGNAL PROCESSING LA English DT Article DE space-time block codes (STBC); orthogonal STBC; quasi-orthogonal STBC; non-orthogonal STBC; Hurwitz-Radon families of matrices; diversity analysis ID FULL-DIVERSITY; SYSTEMS AB It is shown that for four-transmitter systems, a family of four-by-four unit-rate complex quasi-orthogonal space-time block codes, where each entry equals a symbol variable up to a change of sign and/or complex conjugation, can be generated from any two independent codes via elementary operations. The two independent groups of codes in the family generally have different properties of diversity, but the codes in each group have the same diversity provided that the differential symbol constellation is symmetric. It is also shown that for four-transmitter systems, an eight-by-four unit-rate complex linear dispersion space-time block code can be constructed by using Hurwitz-Radon families of matrices of size eight such that diversity three is guaranteed even when all symbols are independently selected from any given constellation. This code is so far the only known unit-rate linear dispersion code that has diversity no less than three for four transmitters under any given constellation. (C) 2008 Elsevier B.V. All rights reserved. C1 [Hua, Yingbo] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Chang, Yu] Rambus Inc, Los Altos, CA 94022 USA. [Xia, Xiang-Gen] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Hua, YB (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM yu.ychang@gmail.com; yhua@ee.ucr.edu; xxia@ee.udel.edu; bsadler@arl.army.mil NR 37 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-1684 J9 SIGNAL PROCESS JI Signal Process. PD AUG PY 2008 VL 88 IS 8 BP 2030 EP 2062 DI 10.1016/j.sigpro.2008.02.011 PG 33 WC Engineering, Electrical & Electronic SC Engineering GA 313OB UT WOS:000256748800010 ER PT J AU Iiames, JS Congalton, R Pilant, A Lewis, T AF Iiames, John S., Jr. Congalton, Russell Pilant, Andrew Lewis, Timothy TI Validation of an integrated estimation of loblolly pine (Pinus taeda L.) leaf area index (LAI) using two indirect optical methods in the southeastern United States SO SOUTHERN JOURNAL OF APPLIED FORESTRY LA English DT Article DE LAI; TRAC; DHP; allometric; MODIS; general ID NET PRIMARY PRODUCTION; NORTH CENTRAL WISCONSIN; LONG-TERM GROWTH; HEMISPHERICAL PHOTOGRAPHY; FORESTS; NUTRIENT; CONIFER; STANDS; WATER; AVAILABILITY AB Quality assessment of satellite-derived leaf area index (LAI) products requires appropriate ground measurements for validation. Since the National Aeronautics and Space Administration launch of Terra (1999) and Aqua (2001), 1-km, 8-day composited retrievals of LAI have been produced for six biome classes worldwide. The evergreen needle leaf biome has been examined at numerous validation sites, but the dominant commercial species in the southeastern United States, labially pine (Pinus taeda), has not been investigated. The objective of this research was to evaluate an in situ optical LAI estimation technique combining measurements from the Tracing Radiation and Architecture of Canopies (TRAC) optical sensor and digital hemispherical photography (DHP) in the southeastern US P. taeda, forests. Stand-level LAI estimated from allometric regression equations developed from whole-free harvest data were compared to TRAC-DHP optical LAI estimates at a study site located in the North Carolina Sandhills Region. Within-shoot clumping, (i.e., the needle-to-shoot area ratio [gamma(E)]) was estimated at 1.21 and fell within the range of previously reported values for coniferous species (1.2-2.1). The woody-to-total area ratio (alpha = 0.31) was within the range of other published results (0.11-0.34). Overall, the indirect optical TRAC-DHP method of determining LAI was similar to LAI estimates that had been derived from allometric equations from whole-tree harvests. The TRAC-DHP yielded a value 0.14 LAI units below that retrieved from stand-level whole-tree harvest allometric equations. DHP alone yielded the best LAI estimate, a 0.04 LAI unit differential compared with the same allometrically derived LAI. C1 [Iiames, John S., Jr.] US EPA, Landscape Characterizat Branch, Res Triangle Pk, NC 27612 USA. [Congalton, Russell] Univ New Hampshire, Durham, NH 03824 USA. [Lewis, Timothy] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Iiames, JS (reprint author), US EPA, Landscape Characterizat Branch, 109 TW Alexander Dr,MD E243-05, Res Triangle Pk, NC 27612 USA. EM iiames.john@epa.gov; russ.congalton@unh.edu; Pilant.drew@epa.gov; Timothy.e.lewis@erdc.usace.army.mil FU U.S. Environmental Protection Agency FX We would also like to thank Dr. Lee Allen and Tim Albaugh from North Carolina Stare University for their input into this project. Also, Pete Anderson, with the United States Forest Service was especially helpful with location/access issues at the SETRES site. Sylvain Leblanc from the Canadian Center for Remote Sensing was very helpful with his review and input into indirect optical LAI measurement theory. Notice: The U.S. Environmental Protection Agency funded and conducted the research described in this paper. Although this work was reviewed by EPA and has been approved for publication, it may not necessarily reflect official Agency policy. Mention of any trade names or commercial products does not constitute endorsement or recommendation for use. NR 55 TC 6 Z9 6 U1 0 U2 9 PU SOC AMER FORESTERS PI BETHESDA PA 5400 GROSVENOR LANE, BETHESDA, MD 20814 USA SN 0148-4419 J9 SOUTH J APPL FOR JI South. J. Appl. For. PD AUG PY 2008 VL 32 IS 3 BP 101 EP 110 PG 10 WC Forestry SC Forestry GA 338EV UT WOS:000258489600001 ER PT J AU Taylor, SF Heidenreich, D AF Taylor, Shawn F. Heidenreich, Danny TI Isolated medial cuneiform fracture: A Special Forces soldier with a rare injury SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE cuneiform; diagnosis; fracture; military ID DISLOCATION; FOOT; BONE AB Isolated cuneiform fractures rarely occur, but must be considered in the differential diagnosis for midfoot injuries. Along with other nondisplaced, nondislocated midfoot injuries, these fractures are commonly missed or delayed in diagnosis. A review of the literature reveals only three other reported cases of isolated medial cuneiform fractures. Because of the difficulties with finding nondisplaced, nondislocated cuneiform fractures oil plain film, further studies should be considered. Other medial cuneiform fractures found in the literature were nonisolated. This report describes a case of isolated medial cuneiform fracture in a 26-year-old Special Forces soldier that resulted in a significant delay of diagnosis. C1 [Taylor, Shawn F.] Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC 28310 USA. 7 Special Forces Grp, Ft Bragg, NC USA. RP Taylor, SF (reprint author), Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC 28310 USA. EM shawn.frank.taylor@us.army.mil NR 14 TC 4 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD AUG PY 2008 VL 101 IS 8 BP 848 EP 849 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 339NV UT WOS:000258585200020 PM 18622338 ER PT J AU Baird, DC AF Baird, Drew Craig TI Bilateral lower extremity edema - An atypical presentation of achalasia SO SOUTHERN MEDICAL JOURNAL LA English DT Meeting Abstract C1 [Baird, Drew Craig] Eisenhower Army Med Ctr, Family Med Residency Program, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD AUG PY 2008 VL 101 IS 8 BP 864 EP 864 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 339NV UT WOS:000258585200047 ER PT J AU Hess, JR Dutton, RB Holcomb, JB Scalea, TM AF Hess, John R. Dutton, Richard B. Holcomb, John B. Scalea, Thomas M. TI Giving plasma at a 1 : 1 ratio with red cells in resuscitation: who might benefit? SO TRANSFUSION LA English DT Editorial Material ID MASSIVE TRANSFUSION; TRAUMA; COAGULOPATHY; MORTALITY C1 [Hess, John R.] Univ Maryland, Med Ctr, Blood Bank, Sch Med,Dept Pathol, Baltimore, MD 21201 USA. Univ Maryland, Sch Med, Dept Trauma Anesthesiol, Baltimore, MD 21201 USA. Univ Maryland, Sch Med, Dept Trauma Surg, Baltimore, MD 21201 USA. USA, Inst Surg Res, San Antonio, TX USA. RP Hess, JR (reprint author), Univ Maryland, Med Ctr, Blood Bank, Sch Med,Dept Pathol, N2W50A,22 S Greene St, Baltimore, MD 21201 USA. EM jhess@umm.edu FU NHLBI NIH HHS [1U01HL072359-06] NR 9 TC 32 Z9 32 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD AUG PY 2008 VL 48 IS 8 BP 1763 EP 1765 DI 10.1111/j.1537-2995.2008.01743.x PG 3 WC Hematology SC Hematology GA 332IX UT WOS:000258077800032 PM 18482190 ER PT J AU McCrea, MV Sherali, HD Trani, AA AF McCrea, Michael V. Sherali, Hanif D. Trani, Antonio A. TI A probabilistic framework for weather-based rerouting and delay estimations within an Airspace Planning model SO TRANSPORTATION RESEARCH PART C-EMERGING TECHNOLOGIES LA English DT Article DE collaborative decision-making; probability-nets; model output statistics; time-dependent shortest path; k-means clustering; expected weather delay and disruption factors ID FLOW MANAGEMENT PROBLEM; DECISION-MAKING MODEL; NEURAL-NETWORK; RECOVERY; AIRCRAFT AB In this paper, we develop a novel severe weather-modeling paradigm to be applied within the context of a large-scale Airspace Planning and collaborative decision-making model in order to reroute flights with respect to a specified probability threshold of encountering severe weather, subject to collision safety, airline equity, and sector workload considerations. This approach serves as an alternative to the current practice adopted by the Federal Aviation Administration (FAA) of adjusting flight routes in accordance with the guidelines specified in the National Playbook. Our innovative contributions in this paper include (a) the concept of "Probability-Nets" and the development of discretized representations of various weather phenomena that affect aviation operations; (b) the integration of readily accessible severe weather probabilities from existing weather forecast data provided by the National Weather Service; (c) the generation of flight plans that circumvent severe weather phenomena with specified probability threshold levels, and (d) a probabilistic delay assessment methodology for evaluating planned flight routes that might encounter potentially disruptive weather along its trajectory. Additionally, we conduct an economic benefit analysis using a k-means clustering mechanism in concert with our delay assessment methodology in order to evaluate delay costs and system disruptions associated with variations in probability-net refinement-based information. Computational results and insights are presented based on flight test cases derived from the Enhanced Traffic Management System data provided by the FAA and using weather scenarios derived from the Model Output Statistics forecast data provided by the National Weather Service. (C) 2007 Elsevier Ltd. All rights reserved. C1 [McCrea, Michael V.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Sherali, Hanif D.] Virginia Polytech Inst & State Univ, Grado Dept Ind & Syst Engn 0118, Blacksburg, VA 24061 USA. [Trani, Antonio A.] Virginia Polytech Inst & State Univ, Jr Dept Civil & Environm Engn 0105, Blacksburg, VA 24061 USA. RP McCrea, MV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM michael.mccrea@usma.edu; hanifs@vt.edu; vuela@vt.edu NR 27 TC 7 Z9 8 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-090X J9 TRANSPORT RES C-EMER JI Transp. Res. Pt. C-Emerg. Technol. PD AUG PY 2008 VL 16 IS 4 BP 410 EP 431 DI 10.1016/j.trc.2007.09.001 PG 22 WC Transportation Science & Technology SC Transportation GA 326FT UT WOS:000257644600003 ER PT J AU Yang, CP Suidan, MT Zhu, XQ Kim, BJ Zeng, GM AF Yang, Chunping Suidan, Makram T. Zhu, Xueqing Kim, Byung J. Zeng, Guangming TI Effect of gas empty bed contact time on performances of various types of rotating drum biofilters for removal of VOCs SO WATER RESEARCH LA English DT Article DE biofiltration; empty bed contact time; models; rotating drum biofilters; VOCs ID VOLATILE ORGANIC-COMPOUND; LONG-TERM PERFORMANCE; BIOMASS ACCUMULATION; WASTE GASES; BIOLOGICAL CONTACTOR; PHASE BIOFILTRATION; TOLUENE; MODEL; BIODEGRADATION; HEXANE AB The effects of gas empty bed contact time (EBCT), biofilter configuration, and types of volatile organic compounds (VOCs) were evaluated to assess the performance of rotating drum biofilters (RDBs), especially at low EBCT values. Three types of pilot-scale RDBs, a single-layer RDB, a multi-layer RDB, and a hybrid RDB, were examined at various gas EBCTs but at a constant VOC loading rate. Diethyl ether, toluene, and hexane were used separately as model VOC. When EBCT increased from 5.0 to 60 s at a constant VOC loading rate of 2.0 kg COD/(m(3) day), ether removal efficiency increased from 73.1% to 97.6%, from 81.6% to 99.9%, and from 84.0% to 99.9% for the single-layer RDB, the multi-layer RDB, and the hybrid RDB, respectively, and toluene removal efficiency increased from 76.4% to 99.9% and from 84.8% to 99.9% for the multi-layer RDB and the hybrid RDB, respectively. When hexane was used as the model VOC at a constant loading rate of 0.25 kg COD/ (m(3) day), hexane removal efficiency increased from 31.1% to 57.0% and from 29.5% to 50.0% for the multi-layer RDB and hybrid RDB, respectively. The single-layer, multi-layer, and hybrid RDBs exhibited, respectively, the lowest, middle, and highest removal efficiencies, when operated under similar operational loading conditions. Hexane exhibited the lowest removal efficiency, while diethyl ether displayed the highest removal efficiency. The data collected at the various EBCT values correlated reasonably well with a saturation model. The sensitivity of removal efficiency to EBCT varied significantly with EBCT values, VOC properties, and biofilter configurations. Process selection and design for RDB processes should consider these factors. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Yang, Chunping; Zeng, Guangming] Hunan Univ, Coll Environm Sci & Engn, Changsha 410082, Hunan, Peoples R China. [Suidan, Makram T.; Zhu, Xueqing] Univ Cincinnati, Dept Civil & Environm Engn, Cincinnati, OH 45221 USA. [Kim, Byung J.] USA, Construct Engn Res Lab, Champaign, IL 61820 USA. RP Yang, CP (reprint author), Hunan Univ, Coll Environm Sci & Engn, Changsha 410082, Hunan, Peoples R China. EM yangc@hnu.cn; makram.suidan@uc.edu OI Yang, Chunping/0000-0003-3987-2722 FU U.S. Army Construction Engineering Research Laboratory; National Natural Science Foundation of China [50778066]; Ministry of Education of China [NCET-05-0701] FX We thank the U.S. Army Construction Engineering Research Laboratory for financial support. Support from the National Natural Science Foundation of China (Grant No. 50778066) and the Program for New Century Excellent Talents in University from the Ministry of Education of China (Grant No. NCET-05-0701) are also appreciated. NR 42 TC 20 Z9 25 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0043-1354 J9 WATER RES JI Water Res. PD AUG PY 2008 VL 42 IS 14 BP 3641 EP 3650 DI 10.1016/j.watres.2008.05.012 PG 10 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 356BF UT WOS:000259753000008 PM 18684482 ER PT J AU Lee, IC AF Lee, Ivan C. TI Rhodium supported on thermally enhanced zeolite as catalysts for fuel reformation of jet fuels SO CATALYSIS TODAY LA English DT Article; Proceedings Paper CT Symposium on Reforming of Liquid Hydrocarbon Fuels for Fuel Cell Applications held at the 234th ACS National Meeting CY AUG 19-23, 2007 CL Boston, MA SP Amer Chem Soc DE jet fuel; JP8; fuel reforming; rhodium; hydrogen; fuel processing; zeolite ID RARE-EARTH CATIONS; Y-ZEOLITES; HIGHER HYDROCARBONS; PARTIAL OXIDATION; CRACKING; DECANE; JP-8; MECHANISMS; HEXADECANE; HYDROGEN AB Autothermal reformation of military jet fuel (1096 ppmw sulfur) was investigated with rhodium supported on thermally stabilized Y zeolite catalysts. The zeolite catalysts were thermally stabilized by ion exchanging with nitrate solutions of rare-earth metals (La, Ce, Sm, Gd, Dy and Er). Surface area analyses indicated that the exchanged zeolite could maintain its porous structure as high as 950 degrees C instead of 800 degrees C for a commercial NaY zeolite. The structure of the exchanged zeolite was characterized by X-ray diffraction (XRD). Rh-SmNaY zeolite reforming catalysts were prepared by incipient wetness and organometallic synthesis. The JP8 reforming experiments were performed in a short contact time adiabatic reactor with a monolithic catalyst with the addition of air and steam at a temperature below 920 degrees C. The effects of steam and fuel-to-air ratio (C/O ratio) were studied. Hydrogen and carbon monoxide were produced as the main products. Durability tests were performed with Rh/SmNaY-zeolite catalysts. This work shows that zeolite based catalysts can convert transportation fuels such as high sulfur jet fuel (over 1000 ppmw S) to syngas for solid oxide fuel cell applications. Published by Elsevier B.V. C1 USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. RP Lee, IC (reprint author), USA, Res Lab, AMSRD ARL SE DC, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ilee@arl.army.mil RI Lee, Ivan/H-6444-2011 NR 20 TC 25 Z9 25 U1 2 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-5861 J9 CATAL TODAY JI Catal. Today PD JUL 31 PY 2008 VL 136 IS 3-4 BP 258 EP 265 DI 10.1016/j.cattod.2008.03.027 PG 8 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical SC Chemistry; Engineering GA 317JE UT WOS:000257015200010 ER PT J AU Glaspell, G Anderson, J Wilkins, JR Ei-Shall, MS AF Glaspell, Garry Anderson, John Wilkins, James R. Ei-Shall, M. Samy TI Vapor phase synthesis of upconverting Y2O3 nanocrystals doped with Yb3+, Er3+, Ho3+, and Tm3+ to generate red, green, blue, and white light SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID UP-CONVERSION LUMINESCENCE; OPTICAL SPECTROSCOPY; NAYF4 NANOCRYSTALS; ZRO2 NANOCRYSTALS; YTTRIUM-OXIDE; LANTHANIDE; EMISSION; COLLOIDS; ERBIUM AB We report the vapor phase synthesis of upconverting Y2O3 nanocrystals doped with Yb3+, Er3+, Ho3+, and Tm3+ to generate red, green, blue, and white light. Incorporating Er3+ within the Yb3+ doped Y2O3 nanocrystals under 980 nm laser excitation produced orange and yellow upconversion luminescence tunable by varying the Yb3+ concentration. The Yb3+, Er3+, and Tm3+ codoped Y2O3 nanocrystals exhibited nearly equal intensities of the red, green, and blue emissions upon 980 nm laser excitation. White light can be produced by adjusting the concentrations of the Ln(3+) ions within the Y2O3 nanocrystals. C1 [Glaspell, Garry; Wilkins, James R.; Ei-Shall, M. Samy] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. [Glaspell, Garry; Anderson, John] USA, Ctr Res Dev & Engn, Alexandria, VA 22315 USA. RP Ei-Shall, MS (reprint author), Virginia Commonwealth Univ, Dept Chem, Box 2006, Richmond, VA 23284 USA. EM mselshal@vcu.edu NR 22 TC 77 Z9 80 U1 3 U2 44 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 31 PY 2008 VL 112 IS 30 BP 11527 EP 11531 DI 10.1021/jp801597u PG 5 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 330FZ UT WOS:000257927100067 ER PT J AU Das, R Hammamieh, R Neill, R Ludwig, GV Eker, S Lincoln, P Ramamoorthy, P Dhokalia, A Mani, S Mendis, C Cummings, C Kearney, B Royaee, A Huang, XZ Paranavitana, C Smith, L Peel, S Kanesa-Thasan, N Hoover, D Lindler, LE Yang, D Henchal, E Jett, M AF Das, Rina Hammamieh, Rasha Neill, Roger Ludwig, George V. Eker, Steven Lincoln, Patrick Ramamoorthy, Preveen Dhokalia, Apsara Mani, Sachin Mendis, Chanaka Cummings, Christiano Kearney, Brian Royaee, Atabak Huang, Xiao-Zhe Paranavitana, Chrysanthi Smith, Leonard Peel, Sheila Kanesa-Thasan, Niranjan Hoover, David Lindler, Luther E. Yang, David Henchal, Erik Jett, Marti TI Early indicators of exposure to biological threat agents using host gene profiles in peripheral blood mononuclear cells SO BMC INFECTIOUS DISEASES LA English DT Article ID YERSINIA-PESTIS; EXPRESSION PATTERNS; BACILLUS-ANTHRACIS; INHALATIONAL ANTHRAX; ADP-RIBOSYLATION; GUINEA-PIGS; IN-VITRO; TOXIN; INFECTION; RESPONSES AB Background: Effective prophylaxis and treatment for infections caused by biological threat agents (BTA) rely upon early diagnosis and rapid initiation of therapy. Most methods for identifying pathogens in body fluids and tissues require that the pathogen proliferate to detectable and dangerous levels, thereby delaying diagnosis and treatment, especially during the prelatent stages when symptoms for most BTA are indistinguishable flu-like signs. Methods: To detect exposures to the various pathogens more rapidly, especially during these early stages, we evaluated a suite of host responses to biological threat agents using global gene expression profiling on complementary DNA arrays. Results: We found that certain gene expression patterns were unique to each pathogen and that other gene changes occurred in response to multiple agents, perhaps relating to the eventual course of illness. Nonhuman primates were exposed to some pathogens and the in vitro and in vivo findings were compared. We found major gene expression changes at the earliest times tested post exposure to aerosolized B. anthracis spores and 30 min post exposure to a bacterial toxin. Conclusion: Host gene expression patterns have the potential to serve as diagnostic markers or predict the course of impending illness and may lead to new stage-appropriate therapeutic strategies to ameliorate the devastating effects of exposure to biothreat agents. C1 [Das, Rina; Hammamieh, Rasha; Neill, Roger; Ramamoorthy, Preveen; Dhokalia, Apsara; Mani, Sachin; Mendis, Chanaka; Cummings, Christiano; Jett, Marti] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. [Ludwig, George V.; Smith, Leonard; Kanesa-Thasan, Niranjan; Henchal, Erik] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA. [Eker, Steven; Lincoln, Patrick] SRI Int, Comp Sci Lab, Menlo Pk, CA 94025 USA. [Kearney, Brian] Geocenters Inc, Rockville, MD USA. [Royaee, Atabak] Georgetown Univ, Dept Chem, Washington, DC 20057 USA. [Huang, Xiao-Zhe; Paranavitana, Chrysanthi; Hoover, David; Lindler, Luther E.] Walter Reed Army Inst Res, Dept Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Peel, Sheila] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. RP Jett, M (reprint author), Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. EM dasr2@nhlbi.nih.gov; rasha.hammamieh@amedd.army.mil; roger.neill@us.army.mil; george.ludwig@det.amedd.army.mil; eker@csl.sri.com; lincoln@csl.sri.com; ramamoorthyp@medimmune.com; apsara.dhokalia@us.army.mil; sachin.mani@na.amedd.army.mil; mendisc@uwplatt.edu; christiano.cummings@na.amedd.army.mil; brian.kearney@det.amedd.army.mil; Atabak.Royaee@finnegan.com; Xiaozhe.huang@na.amedd.army.mil; chrysanthi.paranavitana@na.amedd.army.mil; leonard.smith@det.amedd.army.mil; speel@hivresearch.org; Niranjan.Kanesa_Thasan@cambis.com; david.hoover@DVC.com; Luther.lindler@us.army.mil; yangdc@georgetown.edu; erik.henchal@fda.hhs.gov; marti.jett@us.army.mil RI Yang, David/A-7294-2009 FU Defense Advanced Research Projects Agency (DARPA); Defense Threat Reduction Agency [G0020_04_WR_B] FX This work was supported by the Defense Advanced Research Projects Agency (DARPA) and by the Defense Threat Reduction Agency, Project Number: G0020_04_WR_B. NR 44 TC 5 Z9 5 U1 1 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD JUL 30 PY 2008 VL 8 AR 104 DI 10.1186/1471-2334-8-104 PG 16 WC Infectious Diseases SC Infectious Diseases GA 356ZB UT WOS:000259815000001 PM 18667072 ER PT J AU Jonas, T Rixen, C Sturm, M Stoeckli, V AF Jonas, Tobias Rixen, Christian Sturm, Matthew Stoeckli, Veronika TI How alpine plant growth is linked to snow cover and climate variability SO JOURNAL OF GEOPHYSICAL RESEARCH-BIOGEOSCIENCES LA English DT Article ID ARCTIC TUNDRA; SWISS ALPS; LONG-TERM; VEGETATION; PHENOLOGY; ABUNDANCE; RANUNCULACEAE; EVOLUTIONARY; TEMPERATURE; GRASSLAND AB [1] Recent climate models predict future changes in temperature and precipitation in the Alps. To assess the potential response of alpine plant communities to climate change, we analyzed specific and combined effects of temperature, precipitation, and snow season timing on the growth of plants. This analysis is based on data from 17 snow meteorological stations and includes plant growth records from the same sites over 10 years. Using multiple regression and path analysis, we found that plant growth was primarily driven by climatic factors controlled by the timing of the snow season. Air temperature and precipitation before snow-up and after melt-out yielded the greatest direct impact on maximum plant height as well as growth rates. The variability of environmental drivers between sites versus between years had different effects on plant growth: e. g., sites with early melt-out dates hosted plant communities with tall, slow-growing vegetation. But interannual variations in melt-out dates at a given site did not produce measurable differences in plant growth performance. However, high temperatures after melt-out invariably resulted in a shortened growth period. We speculate that the plant growth patterns we observed in response to climate variation between sites are indicative of the long-term responses of alpine plant communities to persistent climate changes. With most climate models indicating shorter winters, we thus expect alpine grasslands in the Alps to display an enhanced biomass production in the future. C1 [Jonas, Tobias; Rixen, Christian; Stoeckli, Veronika] Swiss Fed Inst Snow & Avalanche Res SLF, WSL, CH-7260 Davos, Switzerland. [Sturm, Matthew] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AL USA. RP Jonas, T (reprint author), Swiss Fed Inst Snow & Avalanche Res SLF, WSL, CH-7260 Davos, Switzerland. EM jonas@slf.ch OI Rixen, Christian/0000-0002-2486-9988 NR 54 TC 59 Z9 60 U1 3 U2 50 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-BIOGEO JI J. Geophys. Res.-Biogeosci. PD JUL 30 PY 2008 VL 113 IS G3 AR G03013 DI 10.1029/2007JG000680 PG 10 WC Environmental Sciences; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA 333LD UT WOS:000258153100003 ER PT J AU Lyon, JA Angov, E Fay, MP Sullivan, JS Girourd, AS Robinson, SJ Bergmann-Leitner, ES Duncan, EH Darko, CA Collins, WE Long, CA Barnwell, JW AF Lyon, Jeffrey A. Angov, Evelina Fay, Michael P. Sullivan, Joann S. Girourd, Autumn S. Robinson, Sally J. Bergmann-Leitner, Elke S. Duncan, Elizabeth H. Darko, Christian A. Collins, William E. Long, Carole A. Barnwell, John W. TI Protection Induced by Plasmodium falciparum MSP1(42) Is Strain-Specific, Antigen and Adjuvant Dependent, and Correlates with Antibody Responses SO PLOS ONE LA English DT Article AB Vaccination with Plasmodium falciparum MSP1(42)/complete Freund's adjuvant (FA) followed by MSP1(42)/incomplete FA is the only known regimen that protects Aotus nancymaae monkeys against infection by erythrocytic stage malaria parasites. The role of adjuvant is not defined; however complete FA cannot be used in humans. In rodent models, immunity is strain-specific. We vaccinated Aotus monkeys with the FVO or 3D7 alleles of MSP1(42) expressed in Escherichia coli or with the FVO allele expressed in baculovirus (bv) combined with complete and incomplete FA, Montanide ISA-720 (ISA-720) or AS02A. Challenge with FVO strain P. falciparum showed that suppression of cumulative day 11 parasitemia was strain-specific and could be induced by E. coli expressed MSP1(42) in combination with FA or ISA-720 but not with AS02A. The coli42-FVO antigen induced a stronger protective effect than the bv42-FVO antigen, and FA induced a stronger protective effect than ISA-720. ELISA antibody (Ab) responses at day of challenge (DOC) were strain-specific and correlated inversely with c-day 11 parasitemia (r = -0.843). ELISA Ab levels at DOC meeting a titer of at least 115,000 ELISA Ab units identified the vaccinees not requiring treatment (noTx) with a true positive rate of 83.3% and false positive rate of 14.3%. Correlation between functional growth inhibitory Ab levels (GIA) and cumulative day 11 parasitemia was weaker (r = -0.511), and was not as predictive for a response of noTx. The lowest false positive rate for GIA was 30% when requiring a true positive rate of 83.3%. These inhibition results along with those showing that antigen/FA combinations induced a stronger protective immunity than antigen/ISA-720 or antigen/AS02 combinations are consistent with protection as ascribed to MSP1-specific cytophilic antibodies. Development of an effective MSP1(42) vaccine against erythrocytic stage P. falciparum infection will depend not only on antigen quality, but also upon the selection of an optimal adjuvant component. C1 [Lyon, Jeffrey A.; Angov, Evelina; Girourd, Autumn S.; Robinson, Sally J.; Bergmann-Leitner, Elke S.; Duncan, Elizabeth H.; Darko, Christian A.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Fay, Michael P.] NIAID, NIH, Biostat Res Branch, Bethesda, MD USA. [Sullivan, Joann S.; Collins, William E.; Barnwell, John W.] CDC, Natl Ctr Zoonot, Vector Borne & Enter Dis, Div Parasit Dis, Malaria Branch, Atlanta, GA USA. [Long, Carole A.] NIAID, NIH, Dept Malaria & Vector Res, Bethesda, MD USA. RP Lyon, JA (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. EM evelina.angov@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011; OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Fay, Michael P./0000-0002-8643-9625 FU U.S. Agency for International Development [936?6001, AAG-P- 00-98-00006, AAG-P-00-98-00005]; National Institutes of Health and Centers for Disease Control and Prevention [NIAID YIAI-0438-03/ CDC C100-042]; United States Army Medical Research and Materiel Command FX This work was supported by the U.S. Agency for International Development under project number 936?6001, award number AAG-P- 00-98-00006, and award number AAG-P-00-98-00005, by the National Institutes of Health and Centers for Disease Control and Prevention Interagency Agreement under grant number NIAID YIAI-0438-03/ CDC C100-042, and by the United States Army Medical Research and Materiel Command. NR 52 TC 54 Z9 55 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 30 PY 2008 VL 3 IS 7 AR e2830 DI 10.1371/journal.pone.0002830 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 420QM UT WOS:000264304300049 PM 18665258 ER PT J AU Lentine, KL Rocca-Rey, LA Bacchi, G Wasi, N Schmitz, L Salvalaggio, PR Abbott, KC Schnitzler, MA Neri, L Brennan, DC AF Lentine, Krista L. Rocca-Rey, Lisa A. Bacchi, Giuliana Wasi, Nadia Schmitz, Leslie Salvalaggio, Paolo R. Abbott, Kevin C. Schnitzler, Mark A. Neri, Luca Brennan, Daniel C. TI Obesity and cardiac risk after kidney transplantation: Experience at one center and comprehensive literature review SO TRANSPLANTATION LA English DT Article; Proceedings Paper CT 8th American Transplant Congress CY MAY 31-JUN 04, 2008 CL Toronto, CANADA SP Amer Soc Transplant Surg, Amer Soc Transplantat DE atrial fibrillation; body mass index; congestive heart failure; ischemic heart disease; kidney transplant; myocardial infarction; obesity ID BODY-MASS-INDEX; CONGESTIVE-HEART-FAILURE; RENAL-ALLOGRAFT SURVIVAL; CARDIOVASCULAR-DISEASE; ATRIAL-FIBRILLATION; UNITED-STATES; SHORT-TERM; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; WEIGHT-GAIN AB Background. The cardiac implications of obesity in kidney transplant recipients are not well-described. Methods. We examined associations of body mass index (BMI) at transplant with posttransplant cardiac risk among 1102 renal allograft recipients at a single center in 1991 to 2004. Cumulative posttransplant incidences of congestive heart failure (CHF), atrial fibrillation (AF), myocardial infarction, and a composite of these cardiac diagnoses were estimated by the Kaplan-Meier method. Bivariate (hazards ratio) and covariate (adjusted hazards ratio) relationships of BMI increments with cardiac risk were modeled by Cox's regression. We also systematically reviewed the literature on BMI and cardiac events after transplant. Results. In the local data, 5-year cumulative incidence of any cardiac diagnosis rose from 8.67% to 29.35% across the lowest to highest BMI quartiles (P=0.02), driven primarily by increases in CHF and AF. In contrast, the rate of myocardial infarction did not differ by BMI quartile (P=0.56). Each 5 UBMI in crease predicted 25% higher risk of the cardiac composite (hazards ratio 1.25, 95% CI 1.07-1.47, P=0.005), a relationship that persisted with significance after covariate adjustment (adjusted hazards ratio 1.19, 95% CI 1.00-1.43, P=0.049). BMI independently predicted cardiac risk in Subcohorts with pretransplant heart disease and with nondiabetic renal failure. Data front 26 original articles support BMI as a risk factor for posttransplant CHF and AF, whereas findings for coronary/ischemic outcomes are inconsistent and predominantly negative. Conclusions. High BMI at transplant predicts increased cardiac risk, especially of CHF and AF. Further research should examine whether obesity treatment modifies cardiac risk after kidney transplantation. C1 [Lentine, Krista L.; Rocca-Rey, Lisa A.; Bacchi, Giuliana; Salvalaggio, Paolo R.; Schnitzler, Mark A.; Neri, Luca] St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63104 USA. [Lentine, Krista L.; Wasi, Nadia; Schmitz, Leslie] St Louis Univ, Sch Med, Div Nephrol, St Louis, MO 63104 USA. [Rocca-Rey, Lisa A.] Univ Milan, San Paolo Hosp, Chair Nephrol, Milan, Italy. [Bacchi, Giuliana] S Orsola Univ, Div Nephrol Dialysis & Transplantat, Bologna, Italy. [Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Brennan, Daniel C.] Washington Univ, Sch Med, Div Nephrol, St Louis, MO USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Sch Med, Salus Ctr 2nd Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentine.krista@stanfordalumni.org OI Abbott, Kevin/0000-0003-2111-7112 FU NIDDK NIH HHS [P30 DK079333, K08 DK073036, K08 DK 073036, K24 DK002886, K08 DK073036-03, P30 DK 079333] NR 50 TC 29 Z9 30 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD JUL 27 PY 2008 VL 86 IS 2 BP 303 EP 312 DI 10.1097/TP.0b013e31817ef0f9 PG 10 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 329RE UT WOS:000257887500021 PM 18645495 ER PT J AU White, JR Shannon, RD Weltzin, JF Pastor, J Bridgham, SD AF White, Jeffrey R. Shannon, Robert D. Weltzin, Jake F. Pastor, John Bridgham, Scott D. TI Effects of soil warming and drying on methane cycling in a northern peatland mesocosm study SO JOURNAL OF GEOPHYSICAL RESEARCH-BIOGEOSCIENCES LA English DT Review ID FRESH-WATER SEDIMENTS; GLOBAL CLIMATE-CHANGE; 2 MICHIGAN PEATLANDS; CARBON TURNOVER; VASCULAR PLANTS; CH4 OXIDATION; RICE ROOTS; NITROGEN MINERALIZATION; DIFFERENT TEMPERATURES; METHANOGENIC ARCHAEA AB Boreal peatlands contain a large portion of the Earth's terrestrial organic carbon and may be particularly vulnerable to changes in climate. Temperatures in boreal regions are predicted to increase during the twenty-first century which may accelerate changes in soil microbial processes and plant community dynamics. In particular, climate-driven changes in plant community composition might affect the pathways and rates of methanogenesis, the plant-mediated emission of methane, and the scavenging of methane by methanotrophic bacteria. Climate change may also affect methane cycling through changes in pore water chemistry. To date, these feedbacks have not been incorporated into the carbon cycling components of climate models. We investigated the effects of soil warming and water table manipulations on methane cycling in a field mesocosm experiment in northern Minnesota, USA. Large intact soil monoliths removed from a bog and fen received infrared warming treatments crossed with water table treatments for 6 years. In years 5 and 6, concentrations, fluxes, and isotopic compositions of methane were measured along with aboveground and belowground net primary productivity and pore water concentrations of acetate, sulfate, ammonium, nitrate, and dissolved organic carbon. Water table level was the dominant control over methane flux in the fen mesocosms, likely through its effect on methane oxidation rates. However, pore water chemistry and plant productivity were important secondary factors in explaining methane flux in the fen mesocosms, and these factors appeared to be the predominant controls over methane flux in the bog mesocosms. The water table and IR treatments had large effects on pore water chemistry and plant productivity, so the indirect effects of climate change appear to be just as important as the direct effects of changing temperature and water table level in controlling future methane fluxes from northern peatlands. Pore water sulfate, ammonium, nitrate, and acetate had a relatively consistent negative relationship with methane emissions, pore water DOC had a positive relationship with methane emissions, and BNPP had mixed effects. The bog mesocosms had much higher methane emissions and pore water methane concentrations than the fen mesocosms, despite a much lower average water table level and peat that is a poor substrate for methanogenesis. We suggest that the relatively high methane fluxes in the bog mesocosms can be explained through their low concentrations of inhibitory pore water compounds, high concentrations of DOC, and high plant productivity. Stable isotopic data from pore water support acetate fermentation as the principal pathway of methanogenesis in bog mesocosms (mean delta(13) CH(4) = -41.0%, mean delta D-CH(4) = -190%). Fen mesocosms had lower pore water concentrations and emissions of methane than bog mesocosms, despite much higher methane production potentials in fen peat. The methane from the fen mesocosms was isotopically heavy (mean delta(13)CH(4) = -28.9%, mean delta D-CH(4) = -140%), suggesting a strong oxidative sink. This is likely related to the dominance of graminoid vegetation and the associated oxygen transport into the rhizosphere. Our results illustrate the need for a more robust understanding of the multiple feedbacks between climate forcing and plant and microbial feedbacks in the response of northern peatlands to climate change. C1 [White, Jeffrey R.] Indiana Univ, Biogeochem Labs, Indiana, PA USA. [White, Jeffrey R.] Indiana Univ, Ctr Res Environm Sci, Indiana, PA USA. [Shannon, Robert D.] Penn State Univ, Dept Agr & Biol Engn, University Pk, PA 16802 USA. [Weltzin, Jake F.] USA, Natl Phenol Network, Natl Coordinating Off, Tucson, AZ 85719 USA. [Pastor, John] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA. [Bridgham, Scott D.] Univ Oregon, Ctr Ecol & Evolutionary Biol, Eugene, OR 97403 USA. RP White, JR (reprint author), Indiana Univ, Biogeochem Labs, Indiana, PA USA. EM whitej@indiana.edu RI yang, lixia/D-7815-2011; Pastor, John/F-6241-2011; White, Jeffrey/A-6965-2017 NR 112 TC 28 Z9 31 U1 11 U2 102 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-BIOGEO JI J. Geophys. Res.-Biogeosci. PD JUL 26 PY 2008 VL 113 AR G00A06 DI 10.1029/2007JG000609 PG 18 WC Environmental Sciences; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA 331FW UT WOS:000257999100001 ER PT J AU Dubinskii, M Zhang, J Kudryashov, I AF Dubinskii, Mark Zhang, Jun Kudryashov, Igor TI Single-frequency, Yb-free, resonantly cladding-pumped large mode area Er fiber amplifier for power scaling SO APPLIED PHYSICS LETTERS LA English DT Article ID LASERS AB We report results for a single-frequency (SF) resonantly cladding-pumped Yb-free large mode area (LMA) erbium-doped fiber amplifier (EDFA) with nearly 50% slope efficiency based on a commercial 20/125 mu m Er-doped double-clad LMA fiber with a core numerical aperture of 0.07. We believe that this is the original demonstration of a SF resonantly cladding-pumped LMA EDFA. We obtained a diffraction-limited SF output of 9.3 W, which is also a record power output obtained for resonantly cladding-pumped LMA EDFA. (C) 2008 American Institute of Physics. C1 [Dubinskii, Mark; Zhang, Jun] USA, Res Lab, AMSRL SE EO, Adelphi, MD 20783 USA. [Kudryashov, Igor] Princeton Lightwave Inc, Cranbury, NJ 08512 USA. RP Dubinskii, M (reprint author), USA, Res Lab, AMSRL SE EO, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil NR 9 TC 11 Z9 11 U1 2 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 21 PY 2008 VL 93 IS 3 AR 031111 DI 10.1063/1.2964189 PG 3 WC Physics, Applied SC Physics GA 330UQ UT WOS:000257968700011 ER PT J AU Stephens, DN Kruse, DE Ergun, AS Barnes, S Lu, XM Ferrara, KW AF Stephens, Douglas N. Kruse, Dustin E. Ergun, Arif S. Barnes, Stephen Lu, X. Ming Ferrara, Katherine W. TI Efficient array design for sonotherapy SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article ID DRUG-DELIVERY; PIEZOELECTRIC TRANSDUCER; ULTRASOUND TRANSDUCERS; LIPOSOMES; THERAPY; MODEL AB New linear multi-row, multi-frequency arrays have been designed, constructed and tested as fully operational ultrasound probes to produce confocal imaging and therapeutic acoustic intensities with a standard commercial ultrasound imaging system. The triple-array probes and imaging system produce high quality B-mode images with a center row imaging array at 5.3 MHz and sufficient acoustic power with dual therapeutic arrays to produce mild hyperthermia at 1.54 MHz. The therapeutic array pair in the first probe design (termed G3) utilizes a high bandwidth and peak pressure, suitable for mechanical therapies. The second multi-array design ( termed G4) has a redesigned therapeutic array pair which is optimized for a high time-averaged power output suitable for mild hyperthermia applications. The 'thermal therapy' design produces more than 4 W of acoustic power from the low-frequency arrays with only a 10.5 degrees C internal rise in temperature after 100 s of continuous use with an unmodified conventional imaging system or substantially longer operation at lower acoustic power. The low-frequency arrays in both probe designs were examined and contrasted for real power transfer efficiency with a KLM model which includes all lossy contributions in the power delivery path from system transmitters to the tissue load. Laboratory verification was successfully performed for the KLM-derived estimates of transducer parallel model acoustic resistance and dissipation resistance, which are the critical design factors for acoustic power output and undesired internal heating, respectively. C1 [Stephens, Douglas N.; Kruse, Dustin E.; Ferrara, Katherine W.] Univ Calif Davis, Davis, CA 95616 USA. [Ergun, Arif S.; Barnes, Stephen] Siemens Corp Res Inc, Imaging & Visualizat, Princeton, NJ 08540 USA. [Lu, X. Ming] USA, Siemens Med Solut, Issaquah, WA 98029 USA. RP Stephens, DN (reprint author), Univ Calif Davis, Davis, CA 95616 USA. EM dnstephens@ucdavis.edu; kwferrara@ucdavis.edu RI Ferrara, Katherine/H-5503-2011; Ergun, Arif/G-7718-2014; OI Ferrara, Katherine/0000-0002-4976-9107 FU NCI NIH HHS [R01 CA103828, R01 CA103828-05, R01 CA112356, CA 112356, R01 CA112356-04]; PHS HHS [103828] NR 27 TC 24 Z9 24 U1 2 U2 7 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-9155 J9 PHYS MED BIOL JI Phys. Med. Biol. PD JUL 21 PY 2008 VL 53 IS 14 BP 3943 EP 3969 DI 10.1088/0031-9155/53/14/014 PG 27 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA 321XB UT WOS:000257338700014 PM 18591737 ER PT J AU Mai, WJ Gao, PX Lao, CS Wang, ZL Sood, AK Polla, DL Soprano, MB AF Mai, Wenjie Gao, Puxian Lao, Changshi Wang, Zhong Lin Sood, Ashok K. Polla, Dennis L. Soprano, Martin B. TI Vertically aligned ZnO nanowire arrays on GaN and SiC substrates SO CHEMICAL PHYSICS LETTERS LA English DT Article ID GROWTH; LIGHT AB Growth of vertically aligned ZnO nanowire arrays has been extensively studied on a variety of important semiconductor substrates, such as SiC and GaN. Systematic experiments were carried out to investigate the effect of growth parameters to the quality of the nanowires. In addition, the growth of nanowalls connecting individual aligned nanowires was studied and a growth mechanism was proposed. These conductive and interconnected nanowalls are indispensable for nanodevices to be fabricated on nonconductive substrates for serving as a common electrode. Finally, these nanowire arrays have been integrated as ultra violet detectors, which show good optical performance. (C) 2008 Elsevier B.V. All rights reserved. C1 [Mai, Wenjie; Gao, Puxian; Lao, Changshi; Wang, Zhong Lin] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Sood, Ashok K.] Magnolia Opt Technol Inc, Woburn, MA 01801 USA. [Polla, Dennis L.] DARPA MTO, Def Adv Res Projects Agcy, Arlington, VA 22203 USA. [Soprano, Martin B.] USA, AMSRD AMR WS DP SB, DARPA Programs Off, Redstone Arsenal, AL 35898 USA. RP Wang, ZL (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. EM zhong.wang@mse.gatech.edu RI Gao, Puxian/E-1461-2011; Wang, Zhong Lin/E-2176-2011 OI Wang, Zhong Lin/0000-0002-5530-0380 NR 10 TC 34 Z9 36 U1 0 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUL 20 PY 2008 VL 460 IS 1-3 BP 253 EP 256 DI 10.1016/j.cplett.2008.06.017 PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 325NT UT WOS:000257596300052 ER PT J AU Golden, JW Hooper, JW AF Golden, Joseph W. Hooper, Jay W. TI Heterogeneity in the A33 protein impacts the cross-protective efficacy of a candidate smallpox DNA vaccine SO VIROLOGY LA English DT Article DE orthopoxviruses; smallpox; DNA vaccine; immunogen; cross-protection; monoclonal antibody; polyclonal antibody; B-cell epitope ID EXTRACELLULAR ENVELOPED VIRUS; SECONDARY POXVIRUS INFECTION; OUTER-MEMBRANE PROTEINS; TO-CELL SPREAD; MONOCLONAL-ANTIBODIES; NONHUMAN-PRIMATES; HUMAN MONKEYPOX; MICE; GLYCOPROTEIN; CHALLENGE AB We previously developed a gene-based vaccine, termed 4pox, which targets four orthopoxvirus proteins (A33, L1, B5, and A27). Because any subunit orthopoxvirus vaccine must protect against multiple species of orthopoxviruses, we are interested in understanding the cross-protective potential of our 4pox vaccine target immunogens. In our current studies, we focused on the A33 immunogen. We found one monoclonal antibody against A33, MAb-1G10, which could not bind the monkeypox virus A33 ortholog, A35. MAb-1G10 binding could be rescued if A35 amino acids 118 and 120 were substituted with those from A33. MAb-1G10 has been shown to protect mice from VACV challenge, thus our findings indicated a protective epitope differs among orthopoxviruses. Accordingly, we tested the cross-protective efficacy of a DNA vaccine consisting of A35R against VACV challenge and compared it to vaccination with A33R DNA. Mice vaccinated with A35R had greater mortality and more weight loss compared to those vaccinated with A33R. These findings demonstrate that despite high homology between A33R orthologs, amino acid differences can impact cross-protection. Furthermore, our results caution that adequate cross-protection by any pan-orthopoxvirus subunit vaccine will require not only careful evaluation of cross-protective immunity, but also of targeting of multiple orthopoxvirus immunogens. Published by Elsevier Inc. C1 [Golden, Joseph W.; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. RP Hooper, JW (reprint author), USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. EM jay.hooper@amedd.army.mil OI Hooper, Jay/0000-0002-4475-0415 NR 56 TC 24 Z9 24 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JUL 20 PY 2008 VL 377 IS 1 BP 19 EP 29 DI 10.1016/j.virol.2008.04.003 PG 11 WC Virology SC Virology GA 317SR UT WOS:000257040700003 PM 18482742 ER PT J AU Kim, J Kelly, MJ Lamb, HH Roberts, GW Kiserow, DJ AF Kim, Jaehoon Kelly, M. Jason Lamb, H. Henry Roberts, George W. Kiserow, Douglas J. TI Characterization of palladium (Pd) on alumina catalysts prepared using liquid carbon dioxide SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SUPERCRITICAL-FLUID ROUTE; AEROGEL NANOCOMPOSITES; ACTIVATED CARBON; PLATINUM NANOPARTICLES; METAL NANOPARTICLES; FUEL-CELLS; ADSORPTION; DEPOSITION; NANOTUBES; ELECTROCATALYSTS AB Palladium (II) hexafluoroacetylacetonate (Pd(hfac)(2)) dissolved in liquid carbon dioxide (L-CO2) was used to deposit Pd nanoparticles onto low-surface-area alpha-alumina (13 m(2)/g) and high-surface-area gamma-alumina (207 m(2)/g). These nanoparticles were prepared by contacting Pd(hfac)(2) dissolved in L-CO2 with the alumina at 6.9 MPa and 28.5 degrees C and then slowly venting gaseous CO2 until L-CO2 was completely evaporated. After depressurization to remove the CO2 and unabsorbed Pd(hfac)(2), the impregnated Pd(hfac)(2) was reduced in hydrogen at a relatively low temperature of 75 degrees C. The adsorption isotherm of Pd(hfac)(2) on gamma-alumina suggests a weak interaction between the organometallic compound and the support. The average Pd particle size on the low-surface-area alpha-alumina, measured by scanning electron microscopy, increased from 13.1 +/- 3.5 to 59.9 +/- 11.3 nm, and the metal dispersion, measured by pulsed CO chemisorption, decreased from 11 to 3%, as the Pd loading on the alumina was increased from 0.15 to 1.54 wt %. With the high-surface-area gamma-alumina, Pd particle size, measured by scanning transmission electron microscopy, increased from 3.1 +/- 1.9 to 7.0 +/- 5.9 nm, and the metal dispersion decreased from 56 to 5%, as Pd loading was increased from 0.58 to 3.94 wt %. C1 [Kim, Jaehoon; Kelly, M. Jason; Lamb, H. Henry; Roberts, George W.; Kiserow, Douglas J.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Kiserow, Douglas J.] USA, Res Off, Div Chem Sci, Res Triangle Pk, NC 27709 USA. [Kim, Jaehoon] Korea Inst Sci & Technol, Energy & Environm Res Div, Seoul 136791, South Korea. RP Roberts, GW (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM groberts@eos.ncsu.edu RI Kim, Jaehoon/G-6116-2014 OI Kim, Jaehoon/0000-0001-6188-7571 NR 25 TC 12 Z9 14 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 17 PY 2008 VL 112 IS 28 BP 10446 EP 10452 DI 10.1021/jp711495n PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 324TP UT WOS:000257542600018 ER PT J AU Arguin, PM Weina, PJ Dougherty, CP AF Arguin, Paul M. Weina, Peter J. Dougherty, Cindy P. TI Artesunate for malaria SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Arguin, Paul M.; Dougherty, Cindy P.] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. [Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Arguin, PM (reprint author), Ctr Dis Control & Prevent, Atlanta, GA 30333 USA. RI Weina, Peter/A-2120-2011 NR 1 TC 1 Z9 1 U1 0 U2 0 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 17 PY 2008 VL 359 IS 3 BP 313 EP 313 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 326KD UT WOS:000257656600021 PM 18635440 ER PT J AU Collamer, AN Guerrero, KT Henning, JS Battafarano, DF AF Collamer, Angelique N. Guerrero, Karen T. Henning, Jeffery S. Battafarano, Daniel F. TI Psoriatic skin lesions induced by tumor necrosis factor antagonist therapy: A literature review and potential mechanisms of action SO ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH LA English DT Article ID FACTOR-ALPHA ANTAGONISTS; NEW-ONSET; RHEUMATOID-ARTHRITIS; INFLIXIMAB TREATMENT; PUSTULAR ERUPTION; ANTIBODY THERAPY; INTERFERON-ALPHA; ADVERSE-REACTION; BLOCKING-AGENTS; CROHNS-DISEASE AB Objective. Numerous reports of the induction or worsening of psoriasis in patients treated with tumor necrosis factor (TNF) antagonists indicate that this is not a rare phenomenon. The etiology of this paradoxical clinical response remains unclear. The aim of this study was to describe similar cases, conduct a comprehensive analysis of the literature, explore possible immunologic mechanisms of action of this perplexing reaction, and recommend management options. Methods. A systematic literature review was performed using the PubMed and Medline databases (1996 to September 2007) searching the index terms "infliximab," "etanercept," "adalimumab," "tumor necrosis factor alpha inhibitor," and "TNF inhibitor," combined with the terms "psoriasis," "pustular," "skin," "rash," and "palmoplantar." All relevant articles in English were reviewed. Pertinent secondary references were also analyzed. Results. According to the literature, new-onset psoriasis may occur any time after initiation of TNF antagonist therapy, is often of an uncommon morphology, may respond to psoriasis treatments, and usually resolves with TNF discontinuation. The pathogenesis of this response appears to involve a disruption in cytokine balance following TNF inhibition, resulting in the up-regulation of plasmacytoid dendritic cells and the subsequent production of unopposed interferon-a, following a triggering event in predisposed individuals. Conclusion. TNF antagonist-induced psoriasis is a newly recognized adverse effect of these medications that typically does not require therapy cessation. We recommend aggressive treatment of the skin disease and consideration of a change in the TNF antagonist if the lesions are unresponsive to conventional psoriasis treatment. C1 [Collamer, Angelique N.] Brooke Army Med Ctr, Rheumatol Serv, Ft Sam Houston, TX 78234 USA. RP Collamer, AN (reprint author), Brooke Army Med Ctr, Rheumatol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM angelique.collamer@amedd.army.mil NR 48 TC 153 Z9 159 U1 2 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0004-3591 J9 ARTHRIT RHEUM-ARTHR JI Arthritis Rheum-Arthritis Care Res. PD JUL 15 PY 2008 VL 59 IS 7 BP 996 EP 1001 DI 10.1002/art.23835 PG 6 WC Rheumatology SC Rheumatology GA 325PY UT WOS:000257602000013 PM 18576309 ER PT J AU Opsenica, DM Terzic, N Smith, PL Yang, Y Anova, L Smith, KS Solaja, BA AF Opsenica, Dejan M. Terzic, Natasa Smith, Philip L. Yang, Youngsun Anova, Lalaine Smith, Kirsten S. Solaja, Bogdan A. TI Mixed tetraoxanes containing the acetone subunit as antimalarials SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE mixed steroidal tetraoxanes; cholic acid; antimalarials; antiproliferatives; metabolic stability ID MALARIA-INFECTED MICE; ARTEMISININ DERIVATIVES; 1,2,4,5-TETRAOXANES; DRUGS AB Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi- drug resistant TM91C235 strain. Amine 8 cured all mice at the dose of 160 mg/kg/day, while the anilide 9 exhibited MCD <= 20 mg/kg/day. The diol 13 was most potent antiproliferative with GI(50), TGI, LC50 MG_MID 0.98 mu M, 3.80 mu M, 11.22 mu M, respectively. All tested compounds showed no toxic effects. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade 11001, Serbia. [Opsenica, Dejan M.; Terzic, Natasa] Inst Chem Technol & Met, Belgrade, Serbia. [Smith, Philip L.; Yang, Youngsun; Anova, Lalaine; Smith, Kirsten S.] Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 158, Belgrade 11001, Serbia. EM bsolaja@chem.bg.ac.yu OI Solaja, Bogdan/0000-0002-9975-2725 NR 22 TC 11 Z9 11 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD JUL 15 PY 2008 VL 16 IS 14 BP 7039 EP 7045 DI 10.1016/j.bmc.2008.05.017 PG 7 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 328WT UT WOS:000257829600042 PM 18550377 ER PT J AU Gustavson, KE Burton, GA Francingues, NR Reible, DD Vorhees, DJ Wolfe, JR AF Gustavson, Karl E. Burton, G. Allen Francingues, Norman R., Jr. Reible, Danny D. Vorhees, Donna J. Wolfe, John R. TI Evaluating the effectiveness of contaminated-sediment dredging SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article C1 [Gustavson, Karl E.] USA, Engineer Res & Dev Ctr, Washington, DC USA. [Burton, G. Allen] Wright State Univ, Dayton, OH 45435 USA. [Reible, Danny D.] Univ Texas Austin, Austin, TX 78712 USA. [Vorhees, Donna J.] Boston Univ, Boston, MA 02215 USA. RP Gustavson, KE (reprint author), USA, Engineer Res & Dev Ctr, Washington, DC USA. RI Burton, Glenn/Q-9714-2016 OI Burton, Glenn/0000-0002-8660-6294 NR 22 TC 28 Z9 32 U1 3 U2 24 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 15 PY 2008 VL 42 IS 14 BP 5042 EP 5047 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 325WS UT WOS:000257620000006 PM 18754345 ER PT J AU Gruber, JB Nash, KL Sardar, DK Valiev, UV Ter-Gabrielyan, N Merkle, LD AF Gruber, John B. Nash, Kelly L. Sardar, Dhiraj K. Valiev, Uygun V. Ter-Gabrielyan, Nikolay Merkle, Larry D. TI Modeling optical transitions of Er3+(4f(11)) in C-2 and C-3i sites in polycrystalline Y2O3 SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID RARE-EARTH IONS; CRYSTAL-FIELD ANALYSIS; ENERGY-LEVELS; SINGLE CRYSTALS; PHOSPHATE-GLASS; GARNET Y3AL5O12; YTTRIUM OXIDE; KRAMERS IONS; DOPED Y2O3; C2 SITES AB The optical properties of Er3+ in polycrystalline (ceramic), and nanocrystalline forms of cubic (bixbyite) yttrium oxide are modeled based on the absorption spectra obtained between 400 and 1700 nm and the fluorescence spectra observed between 1500 and 1670 nm. Both spectra were obtained at 8 K. The observed crystal-field splitting and the measured intensities of transitions between Stark levels of the L-2S+1(J) multiplet manifolds of Er3+(4f(11)) in both the C-2 and C-3i sites of Y2O3 are analyzed in terms of established models. The inversion symmetry of C-3i sites limits the observed electronic transitions to magnetic dipole transitions between the I-4(13/2) and I-4(15/2) manifolds. There is no spectroscopic evidence for transitions involving other multiplet manifolds of Er3+ ions in C-3i sites. For Er3+ ions in C-2 sites, forced electric dipole transitions are allowed between the J +1/2 Stark levels associated with each manifold. With few exceptions, the crystal-field splitting and the intensities of the transitions between Stark levels are comparable between the nanocrystalline, polycrystalline, and the flame fusion grown crystals of cubic yttrium oxide containing trivalent erbium. (C) 2008 American Institute of Physics. C1 [Gruber, John B.; Nash, Kelly L.; Sardar, Dhiraj K.] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. [Valiev, Uygun V.] Natl Univ Uzbekistan, Fac Phys, Tashkent 700174, Uzbekistan. [Ter-Gabrielyan, Nikolay; Merkle, Larry D.] Army Res Lab, Adelphi, MD 20783 USA. RP Sardar, DK (reprint author), Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. EM dsardar@utsa.edu NR 49 TC 22 Z9 22 U1 2 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 2008 VL 104 IS 2 AR 023101 DI 10.1063/1.2955445 PG 9 WC Physics, Applied SC Physics GA 333TH UT WOS:000258174800001 ER PT J AU Zuo, QH Dienes, JK Middleditch, J Meyer, HW AF Zuo, Q. H. Dienes, J. K. Middleditch, J. Meyer, H. W., Jr. TI Modeling anisotropic damage in an encapsulated ceramic under ballistic impact SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SILICON-CARBIDE; INELASTIC DEFORMATION; BRITTLE MATERIALS; SHOCK RESPONSE; BORON-CARBIDE; PENETRATION; BEHAVIOR; TITANIUM; TARGETS; CRACKS AB This paper presents a study of anisotropic damage and cracking in a hot isostatically pressed assembly of titanium alloy encapsulated AD-995 ceramic under ballistic impact using the statistical crack mechanics approach. Anisotropy of crack growth in the ceramic is illustrated numerically by examining the growth in crack sizes along three orientations. Comparisons with the experimental measurements of the predicted backsurface profile and the damage (cracking) in the ceramic suggest that the model predictions are consistent with the experimental data. Numerical simulation also indicates that a prestress of roughly 2 kbar (200 MPa) compensates for about 1% of initial porosity in the ceramic. A comparison is made to the Rajendran-Grove ceramic model in EPIC which assumes an isotropic crack distribution. (C) 2008 American Institute of Physics. C1 [Zuo, Q. H.] Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA. [Dienes, J. K.; Middleditch, J.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM 87545 USA. [Meyer, H. W., Jr.] USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. RP Zuo, QH (reprint author), Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA. EM zuo@eng.uah.edu NR 33 TC 6 Z9 6 U1 2 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 2008 VL 104 IS 2 AR 023508 DI 10.1063/1.2956509 PG 10 WC Physics, Applied SC Physics GA 333TH UT WOS:000258174800022 ER PT J AU Li, HF Parker, T Tang, F Wang, GC Lu, TM Lee, S AF Li, H. -F. Parker, T. Tang, F. Wang, G. -C. Lu, T. -M. Lee, S. TI Biaxially oriented CaF2 films on amorphous substrates SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE crystal morphology; crystal structure; nanostructures; physical vapor deposition process; calcium compounds ID MOLECULAR-BEAM EPITAXY; THIN-FILMS; TEXTURE DEVELOPMENT; SI FILMS; GROWTH; DEPOSITION; SILICON; LAYERS; SUPERCONDUCTORS; POLYCRYSTALLINE AB Biaxially oriented CaF2 films have been created by first using an oblique incidence vapor flux to deposit CaF2 onto an amorphous surface to form vertically aligned nanorods which served as seeds to grow a more continuous CaF2 capping layer under a subsequent normal incidence flux deposition. The entire film possesses a unique {111} < 121 > biaxial texture as shown by X-ray pole figure analysis and transmission electron microscopy (TEM). This unique texture formation is a result of shadowing and surface diffusion effects. This biaxially oriented film on an amorphous substrate may be useful as a buffer layer to grow active semiconductor devices. (C) 2008 Elsevier B.V. All rights reserved. C1 [Li, H. -F.; Parker, T.; Tang, F.; Wang, G. -C.; Lu, T. -M.] Rensselaer Polytech Inst, Sci Ctr 1C25, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Lee, S.] USA, Armament Res, Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Wang, GC (reprint author), Rensselaer Polytech Inst, Sci Ctr 1C25, Dept Phys Appl Phys & Astron, 110,8th St, Troy, NY 12180 USA. EM wangg@rpi.edu NR 26 TC 30 Z9 30 U1 1 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD JUL 15 PY 2008 VL 310 IS 15 BP 3610 EP 3614 DI 10.1016/j.jcrysgro.2008.04.040 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 336GV UT WOS:000258353200039 ER PT J AU Brown, TM Brouwer, J Samuelsen, GS Holcomb, FH King, J AF Brown, Tim M. Brouwer, Jacob Samuelsen, G. Scott Holcomb, Franklin H. King, Joel TI Dynamic first principles model of a complete reversible fuel cell system SO JOURNAL OF POWER SOURCES LA English DT Article DE reversible fuel cell; dynamic model; PEM fuel cell; PEM electrolyzer; hydride tank ID ENERGY-STORAGE; ELECTROLYZER AB A dynamic model of a discrete reversible fuel cell (RFC) system has been developed in a Matlab Simulink (R) environment. The model incorporates first principles dynamic component models of a proton exchange membrane (PEM) fuel cell, a PEM electrolyzer, a metal hydride hydrogen storage tank, and a cooling system radiator, as well as empirical models of balance of plant components. Dynamic simulations show unique charging and discharging control issues and highlight factors contributing to overall system efficiency. (C) 2008 Elsevier B.V. All rights reserved. C1 [Brown, Tim M.; Brouwer, Jacob; Samuelsen, G. Scott] Univ Calif Irvine, NFCRC, Irvine, CA 92697 USA. [Holcomb, Franklin H.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [King, Joel] USA, Natl Automot Ctr, Warren, MI 48397 USA. RP Brouwer, J (reprint author), Univ Calif Irvine, NFCRC, Irvine, CA 92697 USA. EM jb@nfcrc.uci.edu NR 24 TC 5 Z9 5 U1 2 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JUL 15 PY 2008 VL 182 IS 1 BP 240 EP 253 DI 10.1016/j.jpowsour.2008.03.077 PG 14 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 326FA UT WOS:000257642500030 ER PT J AU Zheleva, T Lelis, A Duscher, G Liu, F Levin, I Das, M AF Zheleva, Tsvetanka Lelis, Aivars Duscher, Gerd Liu, Fude Levin, Igor Das, Mrinal TI Transition layers at the SiO2/SiC interface SO APPLIED PHYSICS LETTERS LA English DT Article ID FIELD-EFFECT-TRANSISTORS; OXIDATION; SILICON; OXIDE; SURFACES; MOSFETS; OXYGEN AB The electrical performance of SiC-based microelectronic devices is strongly affected by the densities of interfacial traps introduced by the chemical and structural changes at the SiO2/SiC interface during processing. We analyzed the structure and chemistry of this interface for the thermally grown SiO2/4H-SiC heterostructure using high-resolution transmission electron microscopy (TEM), Z-contrast scanning TEM, and spatially resolved electron energy-loss spectroscopy. The analyses revealed the presence of distinct layers, several nanometers thick, on each side of the interface; additionally, partial amorphization of the top SiC surface was observed. These interfacial layers were attributed to the formation of a ternary Si-C-O phase during thermal oxidation. (C) 2008 American Institute of Physics. C1 [Zheleva, Tsvetanka; Lelis, Aivars] USA, Res Lab, Adelphi, MD 20783 USA. [Duscher, Gerd; Liu, Fude] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Levin, Igor] NIST, MSEL, Ceram Div, Gaithersburg, MD 20899 USA. [Das, Mrinal] CREE Inc, Durham, NC 27703 USA. RP Zheleva, T (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM tzheleva@arl.army.mil RI Liu, Fude/E-9873-2010; Levin, Igor/F-8588-2010; Duscher, Gerd/G-1730-2014 OI Duscher, Gerd/0000-0002-2039-548X NR 18 TC 87 Z9 88 U1 1 U2 19 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 14 PY 2008 VL 93 IS 2 AR 022108 DI 10.1063/1.2949081 PG 3 WC Physics, Applied SC Physics GA 328KA UT WOS:000257796100057 ER PT J AU Coe, D Fuselier, E Benitez, N Broadhurst, T Frye, B Ford, H AF Coe, D. Fuselier, E. Benitez, N. Broadhurst, T. Frye, B. Ford, H. TI Lensperfect: Gravitational lens mass map reconstructions yielding exact reproduction of all multiple images SO ASTROPHYSICAL JOURNAL LA English DT Article DE dark matter; galaxies : clusters : general; gravitational lensing; methods : data analysis ID DARK-MATTER SUBSTRUCTURE; ADVANCED CAMERA; NONPARAMETRIC RECONSTRUCTION; ABELL-1689; GALAXIES; MODELS; HALOES; WEAK; DEGENERACIES; INVERSION AB We present a new approach to gravitational lens mass map reconstruction. Our mass map solutions perfectly reproduce the positions, fluxes, and shears of all multiple images, and each mass map accurately recovers the under-lying mass distribution to a resolution limited by the number of multiple images detected. We demonstrate our technique given a mock galaxy cluster similar to Abell 1689, which gravitationally lenses 19 mock background galaxies to produce 93 multiple images. We also explore cases in which as few as four multiple images are observed. Mass map solutions are never unique, and our method makes it possible to explore an extremely flexible range of physical ( and unphysical) solutions, all of which perfectly reproduce the data given. Each reconfiguration of the source galaxies produces a new mass map solution. An optimization routine is provided to find those source positions ( and redshifts, within uncertainties) that produce the "most physical'' mass map solution, according to a new figure of merit developed here. Our method imposes no assumptions about the slope of the radial profile or mass following light. However, unlike "nonparametric'' grid-based methods, the number of free parameters that we solve for is only as many as the number of observable constraints ( or slightly greater if fluxes are constrained). For each set of source positions and redshifts, mass map solutions are obtained "instantly'' via direct matrix inversion by smoothly interpolating the deflection field using a recently developed mathematical technique. Our LensPerfect software is straightforward and easy to use, and is publicly available on our Web site. C1 [Coe, D.] CALTECH, Jet Prop Lab, Pasadena, CA 91109 USA. [Coe, D.; Ford, H.] Johns Hopkins Univ, Dept Phys & Astron, Baltimore, MD 21218 USA. [Coe, D.; Benitez, N.] CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain. [Fuselier, E.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Benitez, N.] CSIC, Inst Matemat & Fis Fundamental, E-28006 Madrid, Spain. [Broadhurst, T.] Tel Aviv Univ, Sch Phys & Astron, IL-69978 Tel Aviv, Israel. [Frye, B.] Dublin City Univ, Dept Phys Sci, Dublin 9, Ireland. RP Coe, D (reprint author), CALTECH, Jet Prop Lab, MS 169-327, Pasadena, CA 91109 USA. EM coe@caltech.edu OI Benitez, Narciso/0000-0002-0403-7455 NR 56 TC 32 Z9 32 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0004-637X J9 ASTROPHYS J JI Astrophys. J. PD JUL 10 PY 2008 VL 681 IS 2 BP 814 EP 830 DI 10.1086/588250 PG 17 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 324JX UT WOS:000257516000007 ER PT J AU Holmes, JP Benavides, LC Gates, JD Carmichael, MG Hueman, MT Mittendorf, EA Murray, JL Amin, A Craig, D von Hofe, E Ponniah, S Peoples, GE AF Holmes, Jarrod P. Benavides, Linda C. Gates, Jeremy D. Carmichael, Mark G. Hueman, Matthew T. Mittendorf, Elizabeth A. Murray, James L. Amin, Asna Craig, Dianna von Hofe, Eric Ponniah, Sathibalan Peoples, George E. TI Results of the first phase I clinical trial of the novel Ii-key hybrid preventive HER-2/neu peptide (AE37) vaccine SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID BREAST-CANCER PATIENTS; REGULATORY T-CELLS; MELANOMA-ASSOCIATED ANTIGENS; HER2/NEU E75 VACCINE; INVARIANT CHAIN; OVARIAN-CANCER; AUTOIMMUNE-DISEASES; TUMOR-ANTIGEN; RESPONSES; IMMUNIZATION AB Purpose HER-2/neu is overexpressed in breast cancer and is the source of immunogenic peptides. CD4(+) T-helper peptides for HER-2/neu are being evaluated in vaccine trials. The addition of Ii-Key, a four-amino-acid LRMK modification, increases vaccine potency when compared with unmodified class II epitopes. We present the results of the first human phase I trial of the Ii-Key hybrid HER-2/neu peptide (AE37) vaccine in disease-free, node-negative breast cancer patients. Patients and Methods The dose escalation trial included five dose groups, to determine safety and optimal dose of the hybrid peptide (100 mu g, 500 mu g, 1,000 mu g) and granulocyte-macrophage colony-stimulating factor (GM-CSF; range, 0 to 250 mu g). In the event of significant local toxicity, GM-CSF (or peptide in absence of GM-CSF) was reduced by 50%. Immunologic response was monitored by delayed-type hypersensitivity and [H-3] thymidine proliferative assays for both the hybrid AE37 (LRMK-positive HER-2/neu: 776-790) and AE36 (unmodified HER-2/neu: 776-790). Results All 15 patients completed the trial with no grade 3 to 5 toxicities. Dose reductions occurred in 47% of patients. In the second group (peptide, 500 mu g; GM-CSF, 250 mu g), all patients required dose reductions, prompting peptide-only inoculations in the third group. The vaccine induced dose-dependent immunologic responses in vitro and in vivo to AE37, as well as AE36. Conclusion The hybrid AE37 vaccine seems safe and well tolerated with minimal toxicity if properly dosed. AE37 is capable of eliciting HER-2/neu-specific immune responses, even without the use of an adjuvant. This trial represents the first human experience with the Ii-Key modification, and to our knowledge, AE37 is the first peptide vaccine to show potency in the absence of an immunoadjuvant. C1 [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. Naval Med Ctr San Diego, Dept Med, Div Hematol & Med Oncol, San Diego, CA USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. Walter Reed Army Med Ctr, Dept Med, Hematol & Med Oncol Serv, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD 20814 USA. Windber Med Ctr, Joyce Murtha Breast Care Ctr, Windber, PA USA. Antigen Express, Worcester, MA USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil NR 43 TC 71 Z9 75 U1 0 U2 1 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD JUL 10 PY 2008 VL 26 IS 20 BP 3426 EP 3433 DI 10.1200/JCO.2007.15.7842 PG 8 WC Oncology SC Oncology GA 331XU UT WOS:000258046700023 PM 18612158 ER PT J AU Vaddiraju, S Senecal, K Gleason, KK AF Vaddiraju, Sreeram Senecal, Kris Gleason, Karen K. TI Novel strategies for the deposition of -COOH functionalized conducting copolymer films and the assembly of inorganic nanoparticles on conducting polymer platforms SO ADVANCED FUNCTIONAL MATERIALS LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; ELECTRICAL-CONDUCTIVITY; POLYPYRROLE FILMS; POLY(THIOPHENE-3-ACETIC ACID); POLY(3-THIOPHENEACETIC ACID); AQUEOUS-SOLUTION; PYRROLE; ELECTROPOLYMERIZATION; THIOPHENE; POLY(3,4-ETHYLENEDIOXYTHIOPHENE) AB A method for the preparation of -COOH functionalized conducting copolymer films; toward the ultimate goal of developing resistance-based sensing platforms, is presented. The method involved vapor phase copolymerization of pyrrole with a monomer containing the -COOH functionality, thiophene-3-acetic acid (TAA). This copolymerization strategy aided in avoiding the need to employ brittle poly(thiophene-3-acetic acid) (PTAA) films in sensing applications. In this strategy, variation in the gas phase feed ratio of pyrrole to TAA allowed for the variation of the composition of the copolymer film and further allowed for the variation of both the conductivity and the amount of -COOH functionality in the films. Further, the effect of covalent attachment of silver on the conductivity of the copolymer films is performed and presented. This covalent attachment of silver served the dual purpose of verifying the presence of active -COOH groups on the surface, and also allowed for the quantification of the change in conductivity as a result of such attachment. Use of the conjugated ring containing 4-aminothiophenol as the linker material enhanced the conductivities of the films. In contrast, employing cysteamine to link silver nanoparticles to the copolymer films did not result in any enhancement in the conductivities. An enhancement in the conductivities, ranging from 2 to 1000 times, is observed on covalent attachment of silver nanoparticles to the copolymer films using 4-aminothiophenol as the linker material. This increase depended on the amount of TAA in the films and increased with increasing concentrations of TAA in the films. These results clearly indicate the use of these copolymer films in resistance-based sensing. Further, this covalent attachment could be used as a novel strategy to integrate other inorganic nanomaterials on conducting polymer platforms. C1 [Vaddiraju, Sreeram; Gleason, Karen K.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Senecal, Kris] US Army Natick Soldier Res Dev & Engn Command, Mol Sci & Engn Team, Natick, MA 01760 USA. RP Vaddiraju, S (reprint author), MIT, Dept Chem Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM kkgleasn@mit.edu RI Senecal, Kris/F-3000-2013; Gleason, Karen/G-1471-2013 OI Gleason, Karen/0000-0001-6127-1056 NR 43 TC 36 Z9 36 U1 5 U2 39 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1616-301X J9 ADV FUNCT MATER JI Adv. Funct. Mater. PD JUL 9 PY 2008 VL 18 IS 13 BP 1929 EP 1938 DI 10.1002/adfm.200800196 PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 328OS UT WOS:000257808300009 ER PT J AU Rubins, KH Hensley, LE Bell, GW Wang, CL Lefkowitz, EJ Brown, PO Relman, DA AF Rubins, Kathleen H. Hensley, Lisa E. Bell, George W. Wang, Chunlin Lefkowitz, Elliot J. Brown, Patrick O. Relman, David A. TI Comparative Analysis of Viral Gene Expression Programs during Poxvirus Infection: A Transcriptional Map of the Vaccinia and Monkeypox Genomes SO PLOS ONE LA English DT Article AB Background: Poxviruses engage in a complex and intricate dialogue with host cells as part of their strategy for replication. However, relatively little molecular detail is available with which to understand the mechanisms behind this dialogue. Methodology/Principal Findings: We designed a specialized microarray that contains probes specific to all predicted ORFs in the Monkeypox Zaire (MPXV) and Vaccinia Western Reserve (VACV) genomes, as well as >18,000 human genes, and used this tool to characterize MPXV and VACV gene expression responses in vitro during the course of primary infection of human monocytes, primary human fibroblasts and HeLa cells. The two viral transcriptomes show distinct features of temporal regulation and species-specific gene expression, and provide an early foundation for understanding global gene expression responses during poxvirus infection. Conclusions/Significance: The results provide a temporal map of the transcriptome of each virus during infection, enabling us to compare viral gene expression across species, and classify expression patterns of previously uncharacterized ORFs. C1 [Rubins, Kathleen H.; Relman, David A.] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA USA. [Rubins, Kathleen H.; Brown, Patrick O.] Stanford Univ, Sch Med, Biochem, Stanford, CA USA. [Brown, Patrick O.] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA USA. [Hensley, Lisa E.] US Army Med Res Inst Infect Dis, Frederick, MD USA. [Bell, George W.] Whitehead Inst Biomed Res, Cambridge, MA USA. [Wang, Chunlin; Lefkowitz, Elliot J.; Relman, David A.] Univ Alabama, Birmingham, AL USA. [Relman, David A.] Vet Affairs Palo Alto Hlth Care Syst, Stanford Univ, Sch Med, Dept Med, Palo Alto, CA USA. RP Rubins, KH (reprint author), Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA USA. EM rubins@wi.mit.edu OI Lefkowitz, Elliot/0000-0002-4748-4925 FU NIH [AI54922, AI065359]; DARPA [N65236-99-1-5428]; Horn Foundation; Howard Hughes Medical Institute [Investigator]; NIH/NIAID Viral Bioinformatics Resource Center [HHSN266200400036C]; National Biodefense Analysis and Countermeasures Center/Department of Homeland security [HSHQDC-05-X-00301, HSHQDC-05-X-00035] FX This investigation was supported by NIH Grant AI54922 (D.A.R. and P.O.B.), AI065359 (K.H.R and D.A.R.), DARPA Grant N65236-99-1-5428 (D.A.R.), and a gift from the Horn Foundation (D.A.R. and P.O.B.), as well as the Howard Hughes Medical Institute (P.O.B.). P.O.B. is an Investigator of the Howard Hughes Medical Institute. E.J.L. was supported by the NIH/NIAID Viral Bioinformatics Resource Center, Contract No. HHSN266200400036C. Work at USAMRIID was funded by National Biodefense Analysis and Countermeasures Center/Department of Homeland security contracts #HSHQDC-05-X-00301 and HSHQDC-05-X-00035. None of the funding agencies were involved in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation of the manuscript. The US Army Medical Research Institute and the National Biodefense Analysis and Countermeasures Center reviewed and approved the manuscript. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 41 TC 27 Z9 28 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUL 9 PY 2008 VL 3 IS 7 AR e2628 DI 10.1371/journal.pone.0002628 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 417GZ UT WOS:000264065800030 PM 18612436 ER PT J AU Kumaran, D Rawat, R Ludivico, ML Ahmed, SA Swaminathan, S AF Kumaran, Desigan Rawat, Richa Ludivico, Matthew L. Ahmed, S. Ashraf Swaminathan, Subramanyam TI Structure- and substrate-based inhibitor design for Clostridium botulinum neurotoxin serotype A SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID AMINO-ACID-COMPOSITION; ELECTRON-DENSITY MAPS; ACTIVE-SITE RESIDUES; LIGHT-CHAIN; MOLECULAR-GRAPHICS; CRYSTAL-STRUCTURE; PROTEASE ACTIVITY; TETANUS TOXIN; CLEAVAGE; SYNAPTOBREVIN AB The seven antigenically distinct serotypes of Clostridium botulinum neurotoxins cleave specific soluble N-ethylmaleimidesensitive factor attachment protein receptor complex proteins and block the release of neurotransmitters that cause flaccid paralysis and are considered potential bioweapons. Botulinum neurotoxin type A is the most potent among the clostridial neurotoxins, and to date there is no post-exposure therapeutic intervention available. To develop inhibitors leading to drug design, it is imperative that critical interactions between the enzyme and the substrate near the active site are known. Although enzyme-substrate interactions at exosites away from the active site are mapped in detail for botulinum neurotoxin type A, information about the active site interactions is lacking. Here, we present the crystal structures of botulinum neurotoxin type A catalytic domain in complex with four inhibitory substrate analog tetrapeptides, viz. RRGC, RRGL, RRGI, andRRGM at resolutions of 1.6-1.8 A. These structures show for the first time the interactions between the substrate and enzyme at the active site and delineate residues important for substrate stabilization and catalytic activity. We show that OH of Tyr(366) and NH(2) of Arg(363) are hydrogen-bonded to carbonyl oxygens of P1 and P1' of the substrate analog and position it for catalytic activity. Most importantly, the nucleophilic water is replaced by the amino group of the N-terminal residue of the tetrapeptide. Furthermore, the S1' site is formed by Phe(194), Thr(215), Thr(220), Asp(370), and Arg(363). The K(i) of the best inhibitory tetrapeptide is 157 nM. C1 [Kumaran, Desigan; Rawat, Richa; Swaminathan, Subramanyam] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. [Ludivico, Matthew L.; Ahmed, S. Ashraf] USA, Med Res Inst Infect Dis, Dept Mol Biol, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Swaminathan, S (reprint author), Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. EM swami@bnl.gov NR 50 TC 43 Z9 43 U1 1 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD JUL 4 PY 2008 VL 283 IS 27 BP 18883 EP 18891 DI 10.1074/jbc.M801240200 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 319LR UT WOS:000257165600045 PM 18434312 ER PT J AU Wagner, GW Itin, B AF Wagner, George W. Itin, Boris TI Comment on "Al-27, Ti-47,Ti-49, P-31, and C-13 MAS NMR study of VX, GD, and HD reactions with nanosize Al2O3, conventional Al2O3 and TiO2, and aluminum and titanium metal" SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Editorial Material C1 [Wagner, George W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Itin, Boris] New York Struct Biol Center, New York, NY 10027 USA. RP Wagner, GW (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM george.wagner@us.army.mil NR 2 TC 4 Z9 5 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 3 PY 2008 VL 112 IS 26 BP 9962 EP 9962 DI 10.1021/jp802847m PG 1 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 319HR UT WOS:000257155200061 ER PT J AU Tsai, JW Ayubi, FS Hart, KL Baur, DA Parham, MA Moon, JK Vazquez, R Chasen, AB Zhang, Z Pizarro, JM AF Tsai, John W. Ayubi, Farhan S. Hart, Kristopher L. Baur, Dale A. Parham, Mary A. Moon, Jay K. Vazquez, Raymond Chasen, Arthur B. Zhang, Zhuo Pizarro, Jose M. TI Evaluation of the effect of sildenafil and vascular endothelium growth factor combination treatment on skin flap survival in rats SO AESTHETIC PLASTIC SURGERY LA English DT Article DE VEGF; sildenafil; skin flap; rat ID NITRIC-OXIDE; FACTOR VEGF; ANGIOGENESIS; VIABILITY; CELLS; VASOCONSTRICTION; MECHANISM; VEGF(165); DELIVERY; PATHWAY AB Background Distal ischemic necrosis of surgical flaps remains a challenging problem for the reconstructive surgeon. Recent studies have shown that either sildenafil or vascular endothelium growth factor (VEGF) treatment significantly improves ischemic skin flap viability. In this study, the effect of the combination of sildenafil and VEGF(165) was evaluated on a rat skin flap model using orthogonal polarization spectral imaging and histologic analysis. Methods Rats were assigned to either a sham (n = 31), vehicle (n = 24), sildenafil (n = 24), VEGF (n = 23), or sildenafil and VEGF combination treatment (n = 21) groups. Distances from the distal end of the flap to avascular, stasis, and normal capillary blood flow zones were determined using orthogonal polarization spectral imaging on a skin flap model. Vessel density assessment was done at 7 days post surgery. Results Imaging analysis showed significant reduction in avascular and stasis areas in sildenafil and VEGF combination-treated groups at 7 days post surgery (p < 0.05). The combination-treated group, however, was not significantly different when compared to the group treated with sildenafil only. The sildenafil-treated group showed a significant (p < 0.05) reduction in both areas at day 7 compared to the VEGF and control groups. Histologic analysis showed no significant differences in vessel density between the groups. Conclusion The combination of sildenafil and VEGF decreases the extent of avascular and stasis zones in skin flaps. The skin flap improvement seen with the combination treatment was similar to the sildenafil treatment alone suggesting that enhanced flap survival was due solely to the effect of sildenafil. C1 [Parham, Mary A.; Moon, Jay K.; Zhang, Zhuo; Pizarro, Jose M.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. [Vazquez, Raymond] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Baur, Dale A.] Univ Hosp, Dept Oral & Maxillofacial Surg, Case Med Ctr, Cleveland, OH 44106 USA. [Hart, Kristopher L.] Darnall Army Med Ctr, Dept Oral & Maxillofacial Surg, Ft Hood, TX 76544 USA. [Tsai, John W.; Ayubi, Farhan S.; Chasen, Arthur B.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Pizarro, JM (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. EM Jose.PizarroMatos@us.army.mil NR 26 TC 16 Z9 16 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-216X J9 AESTHET PLAST SURG JI Aesthet. Plast. Surg. PD JUL PY 2008 VL 32 IS 4 BP 624 EP 631 DI 10.1007/s00266-008-9166-2 PG 8 WC Surgery SC Surgery GA 323IN UT WOS:000257439900008 PM 18443849 ER PT J AU Carr, WW Nelson, CMR Hadley, JA AF Carr, Warner W. Nelson, Col. Michael R. Hadley, James A. TI Managing rhinitis: Strategies for improved patient outcomes SO ALLERGY AND ASTHMA PROCEEDINGS LA English DT Article DE allergens; allergic rhinitis; anticholinergics; antihistamines; congestion; decongestants; immunotherapy; intranasal corticosteroids; nonallergic rhinitis; vasomotor rhinitis ID SEASONAL ALLERGIC RHINITIS; AZELASTINE NASAL SPRAY; QUALITY-OF-LIFE; INTRANASAL CORTICOSTEROIDS; NONALLERGIC RHINITIS; EFFICACY; FLUTICASONE; THERAPY; ANTIHISTAMINES; COMBINATION AB Allergic rhinitis affects more than 40 million Americans, with estimated costs reaching $5.3 billion annually. The global impact includes negative effects on quality of life (QOL), sleep, diminished work productivity, and exacerbation of comorbid conditions. An accurate diagnosis of allergic or nonallergic rhinitis is needed before selecting optimal treatment, which call include antihistamines, decongestants, intranasal corticosteroids, immunotherapy, and anticholinergics. It is also important to understand that pharmacologic properties of these different interventions may affect patient satisfaction, compliance, and overall clinical response. This article reviews currently available therapies for allergic rhinitis with a focus oil improving patient outcomes. C1 [Carr, Warner W.] Allergy & Asthma Associates So Calif, Mission Viejo, CA 92691 USA. [Nelson, Col. Michael R.] Walter Reed Army Med Ctr, Dept Allergy, Dept Allergy Immunol, Washington, DC USA. [Hadley, James A.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA. RP Carr, WW (reprint author), Allergy & Asthma Associates So Calif, 27800 Med Ctr Rd,Suite 244, Mission Viejo, CA 92691 USA. EM warnercarr@hotmail.com FU Meda Pharmaceuticals, Inc FX Supported by all educational grant from Meda Pharmaceuticals, Inc. Haymarket Medical Education participated with medical writing assistance Warner W. Carr, M.D., has received grant/research support for Meda Pharmaceuticals Inc., Alcon, AstraZeneca, GlaxoSmithKline, UCB, Schering plough; is a consultant for Meda pharmaceuticals Inc. and Alcon; and is oil the speakers' bureaus for Meda Pharmaceuticals Inc., Alcon, AstraZeneca, GlaxoSmithKline, Schering Plough, Sanofi-Aventis, and Teva Pharmaceuticals. Col. Michael R. Nelson, M.D., Ph.D., has not received grant/research support or funding its a consultant or speaker.James A. Hadley, M.D., is a consultant for Sanofi-Aventis, GlaxoSmithKline, Schering Plough, and Meda Pharmaceuticals Inc. NR 58 TC 16 Z9 17 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 USA SN 1088-5412 J9 ALLERGY ASTHMA PROC JI Allergy Asthma Proc. PD JUL-AUG PY 2008 VL 29 IS 4 BP 349 EP 357 DI 10.2500/aap.2008.29.3145 PG 9 WC Allergy SC Allergy GA 338PD UT WOS:000258519000001 PM 18702880 ER PT J AU Xia, Y Davies, BE Gunning, S AF Xia, Yang Davies, Brett E. Gunning, Sean TI Pruritic acral rash in a child SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material ID GIANOTTI-CROSTI-SYNDROME C1 [Xia, Yang; Gunning, Sean] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Davies, Brett E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Xia, Y (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM Yang.Xia@amedd.army.mil NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL 1 PY 2008 VL 78 IS 1 BP 103 EP 105 PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 327MU UT WOS:000257734000012 PM 18649617 ER PT J AU Hahn, CD Choi, YU Lee, D Frizzi, JD AF Hahn, Christina D. Choi, Yong U. Lee, Daniel Frizzi, James D. TI PNEUMOPERITONEUM DUE TO GASTRIC PERFORATION AFTER CARDIOPULMONARY RESUSCITATION: CASE REPORT SO AMERICAN JOURNAL OF CRITICAL CARE LA English DT Article ID CARDIAC RESUSCITATION; TENSION PNEUMOPERITONEUM; RUPTURE; LACERATIONS; STOMACH AB Background Pneumoperitoneum after cardiopulmonary resuscitation may be due to mediastinal air tracking into the peritoneal cavity via the diaphragmatic hiatus or to gastric perforation. Case Report A 79-year-old woman received Advanced Cardiac Life Support measures in the intensive care unit. Chest compressions and endotracheal intubation were performed; a stable cardiac rhythm and perfusion were restored. A chest radiograph after resuscitation revealed pneumoperitoneum without pneumomediastinum. The patient underwent laparotomy; a 6-cm perforation of the posterior gastric wall along the lesser curve was detected and repaired. Conclusion Gastric perforation after cardiopulmonary resuscitation should be suspected when chest radiographs obtained after resuscitation show pneumoperitoneum without pneumomediastinum. Prompt laparotomy allows detection of gastric perforations and decreases the morbidity associated with rupture of a hollow organ. The incidence of gastric perforation after cardiopulmonary resuscitation may be decreased with early endotracheal intubation, avoidance of esophageal intubation, and expeditious placement of an orogastric tube. (American Journal of Critical Care. 2008; 17: 388,386-387) C1 [Choi, Yong U.] Dwight D Eisenhower Army Med Ctr, Gen Surg Serv, Ft Gordon, GA 30905 USA. RP Choi, YU (reprint author), Dwight D Eisenhower Army Med Ctr, Gen Surg Serv, Ft Gordon, GA 30905 USA. EM yong.u.choi@us.army.mil FU Dwight D Eisenhower Army Medical Center, Fort Gordon, Georgia FX All research was performed at Dwight D Eisenhower Army Medical Center, Fort Gordon, Georgia. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of Defense. Use of or mention of any commercial product in this manuscript does not imply endorsement by the United States Government. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CRITICAL CARE NURSES PI ALISO VIEJO PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA SN 1062-3264 EI 1937-710X J9 AM J CRIT CARE JI Am. J. Crit. Care PD JUL 1 PY 2008 VL 17 IS 4 BP 385 EP 387 PG 3 WC Critical Care Medicine; Nursing SC General & Internal Medicine; Nursing GA 366SJ UT WOS:000260503400016 ER PT J AU Miller, C Bidus, MA Pulcini, JP Maxwell, GL Cosin, JA Rose, GS AF Miller, Caela Bidus, Michael A. Pulcini, Joseph P. Maxwell, G. Larry Cosin, Jonathan A. Rose, G. Scott TI The ability of endometrial biopsies with atypical complex hyperplasia to guide surgical management SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 37th Annual Meeting of the Society-of-Gynecologic-Oncologists CY MAR 22-26, 2006 CL Palm Springs, CA SP Soc Gynecol Oncol DE atypical hyperplasia; endometrial cancer; endometrial hyperplasia ID GYNECOLOGIC-ONCOLOGY-GROUP; WELL-DIFFERENTIATED CARCINOMA; DIAGNOSIS; CANCER; REPRODUCIBILITY; WOMEN; RISK AB OBJECTIVE: This study was undertaken to determine the clinical relevance of "qualifying comments" on pathology reports of complex atypical endometrial hyperplasia. STUDY DESIGN: A retrospective review of endometrial biopsy specimens with atypical hyperplasia at our institutions was performed if subsequent hysterectomy results were available for review. Endometrial biopsy results were graded on an ordinal scale (complex atypical endometrial hyperplasia vs atypical endometrial hyperplasia "cannot rule out a more severe lesion") and compared with pathology obtained at hysterectomy. Data were analyzed by using Fisher's exact test. RESULTS: Endometrial biopsy specimens were associated with carcinoma in 37.5% (18/48) of complex atypical endometrial hyperplasia cases and in 60% (18/30) of atypical endometrial hyperplasia-cancer cases. Atypical endometrial hyperplasia-cancer on biopsy was associated with an increased risk of discovering a malignancy at intermediate/high-risk for lymph node involvement (odds ratio 4.71, P = .0256). CONCLUSION: Biopsy specimens that show atypical endometrial hyperplasia-cancer are associated with an increased risk of finding a cancer at intermediate or high risk for nodal metastasis. C1 [Miller, Caela] Natl Naval Med Ctr, Dept Obstet & Gynecol, Bethesda, MD USA. [Bidus, Michael A.; Maxwell, G. Larry; Rose, G. Scott] US Mil Acad, Inst Canc, Walter Reed Army Med Ctr, Washington, DC USA. [Bidus, Michael A.; Maxwell, G. Larry; Rose, G. Scott] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. [Pulcini, Joseph P.] Brook Army Med Ctr, Dept Pathol, San Antonio, TX USA. [Cosin, Jonathan A.] Washington Hosp Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20010 USA. RP Miller, C (reprint author), Natl Naval Med Ctr, Dept Obstet & Gynecol, Bethesda, MD USA. NR 17 TC 1 Z9 2 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD JUL PY 2008 VL 199 IS 1 AR 69.e1 DI 10.1016/j.ajog.2007.11.070 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 320AD UT WOS:000257205200025 PM 18241812 ER PT J AU Bennett, K Si, YZ Steinbach, T Zhang, J Li, QG AF Bennett, Kent Si, Yuanzheng Steinbach, Thomas Zhang, Jing Li, Qigui TI Pharmacokinetic and pharmacodynamic evaluation of intramuscular artesunate in healthy beagle dogs SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SEVERE FALCIPARUM-MALARIA; ARTEMETHER; QUININE; TRIAL AB Pharmacokinetic and pharmacodynamic responses were evaluated after intramuscular (IM) injection of artesunate (AS). Twelve dogs were injected with IM AS at 2.5, 5, or 10 mg/kg into the left gluteal muscle. A second injection of only diluent was given in the right gluteal muscle. At 24 hours post-injection, plasma creatine kinase (CK) concentrations were elevated above normal. Muscle biopsies showed myocyte necrosis and acute inflammation, which was worse on the treated side. At 7 days after injection, CK concentrations were normal. Muscle biopsies showed mineralization, fibrosis, and chronic inflammation with less difference between sides. Compared with intravenous administration, IM AS resulted in a prolonged half-life for both AS and DHA. Intramuscular AS also had a lower mean dose-adjusted C-max and a higher mean dose-adjusted area under the curve; but produced similar concentrations of dihydroartemisinin. These findings suggest that adverse reactions to IM artesunate are minor and temporary which justify further study of this route in treating severe malaria. C1 [Bennett, Kent; Si, Yuanzheng; Zhang, Jing; Li, Qigui] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Steinbach, Thomas] USN, Med Res Ctr, Dept Pathol, Silver Spring, MD 20910 USA. RP Bennett, K (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Kent.Bennett@us.army.mil; Yuanzheng.Si@amedd.army.mil; Thomas.Steinbach@med.navy.mil; Jing.Zhang@amedd.army.mil; Qigui.Li@amedd.army.mil RI Bennett, Kent/K-2742-2012 NR 6 TC 3 Z9 3 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2008 VL 79 IS 1 BP 36 EP 41 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 322XD UT WOS:000257407700008 PM 18606761 ER PT J AU Putnak, JR de La Barrera, R Burgess, T Pardo, J Dessy, F Gheysen, D Lobet, Y Green, S Endy, TP Thomas, SJ Eckels, KH Innis, BL Sun, W AF Putnak, J. Robert de la Barrera, Rafael Burgess, Timothy Pardo, Jorge Dessy, Francis Gheysen, Dirk Lobet, Yves Green, Sharone Endy, Timothy P. Thomas, Stephen J. Eckels, Kenneth H. Innis, Bruce L. Sun, Wellington TI Comparative evaluation of three assays for measurement of dengue virus neutralizing antibodies SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; INFECTION; CELLS AB Plaque reduction neutralization tests (PRNTs) are commonly used for measuring levels of dengue virus (DENV) neutralizing antibodies. However, these assays lack a standardized format, generally have a low sample throughput, and are labor-intensive. The objective of the present study was to evaluate two alternative DENY neutralizing antibody assays: an enzyme-linked immunosorbent assay-based microneutralization (MN) assay, and a fluorescent antibody cell sorter-based, DC-SIGN expresser dendritic cell (DC) assay. False-positive rates, serotype specificity, reproducibility, sensitivity, and agreement among the assay methods were assessed using well-characterized but limited numbers of coded test sera. Results showed that all three assays had false-positive rates of less than 10% with titers near the cut-off and generally below the estimated limits of detection. All three methods demonstrated a high degree of specificity and good agreement when used to assay sera and serum mixtures from monovalent vaccinees and sera from patients after primary natural infection, with the only notable exception being moderate-to-high neutralizing antibody titers against DENV 2 measured by PRNT in a mixture containing only DENY 3 and DENV 4 sera. The MN and DC assays demonstrated good reproducibility. All three assays were comparable in their sensitivity, except that the PRNT was less sensitive for measuring DENV 4 antibody, and the MN and DC assays were less sensitive for measuring DENV 2 antibody. However, when used to test sera from persons after tetravalent DENV vaccination or secondary DENY infection, there was poor specificity and poor agreement among the different assays. C1 [Putnak, J. Robert; Thomas, Stephen J.] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [de la Barrera, Rafael; Eckels, Kenneth H.] Walter Reed Army Inst Res, Div Regulated Activ, Pilot Bioprod Facil, Silver Spring, MD 20910 USA. [Burgess, Timothy] USN, Med Res Ctr, Silver Spring, MD USA. [Pardo, Jorge] BD Biosci, San Jose, CA 95131 USA. [Dessy, Francis; Gheysen, Dirk; Lobet, Yves] GlaxoSmithKline Biol, Global Vaccine Dev, B-1330 Rixensart, Belgium. [Green, Sharone] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA. [Endy, Timothy P.] SUNY Hlth Sci Ctr, Dept Med, Syracuse, NY 13210 USA. [Innis, Bruce L.] N Amer GlaxoSmithKline, Clin R&D & Med Affair Vaccines Virus Dis, King Of Prussia, PA USA. [Sun, Wellington] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Dengue Branch, San Juan, PR 00920 USA. RP Putnak, JR (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave,Suite 3A12, Silver Spring, MD 20910 USA. EM robert.putnak@na.amedd.army.mil; rafael.delabarrera@na.amedd.army.mil; burgess.namru2@yahoo.com; Jorge_Pardo@bd.com; francis.dessy@gskbio.com; dirk.gheysen@gskbio.com; yves.lobet@gskbio.com; sharone.green@umassmed.edu; endyt@upstate.edu; stephen.thomas@na.amedd.army.mil; kenneth.eckels@amedd.army.mil; bruce.2.innis@gsk.com; wks4@cdc.gov FU NIAID NIH HHS [P01 AI34533] NR 16 TC 34 Z9 36 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2008 VL 79 IS 1 BP 115 EP 122 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 322XD UT WOS:000257407700021 PM 18606774 ER PT J AU Lee, SK Weiss, CA AF Lee, Sung Keun Weiss, Charles A., Jr. TI Multiple oxygen sites in synthetic phyllosilicates with expandable layers: O-17 solid-state NMR study SO AMERICAN MINERALOGIST LA English DT Article DE high-resolution solid-state NMR; phyllosilicates; oxygen sites; 3QMAS NMR; montmorillonite ID ANGLE-SPINNING NMR; NUCLEAR-MAGNETIC-RESONANCE; HIGH-RESOLUTION O-17; TETRAHEDRAL AL-SI; MAS-NMR; ALUMINOSILICATE GLASSES; SI-29 NMR; AL-27 MAS; NATURAL ZEOLITE; HIGH-FIELD AB Recent advances in high-resolution solid-state NMR enabled us to resolve the previously unknown details of atomic configurations around quadrupolar nuclides such as O (O-17, spin 5/2) and aluminum (Al-27, spin 5/2) in phyllosilicates. Here, we report the O-17 ID and 2D NMR (MAS and MQMAS) spectra of synthetic kaolinite-montmorillonite mixtures. Various O sites in the mixtures revealed from O-17 NMR include apical O (Si-VI-O-2(IV)Al), multiple basal O atoms (Si-VI-O-Si-VI and two Si-VI-O-Al-VI sites) in tetrahedral layers, and hydroxyl group with distinct ranges for NMR parameters (quadrupolar coupling constant, C-q and isotropic chemical shift, O-17 delta(iso)). In particular, the structurally relevant NMR parameters (17O delta(iso), C-q, and asymmetry parameter, eta) for two resolved Si-IV-O-Al-VI sites are about 52 +/- 2 ppm, 2.6 +/- 0.2 MHz, and 0.5 for Si-IV-O-Al-IV (I) and about 44.5 +/- 2 ppm, and 3.1 +/- 0.2 MHz, and 0.5 for Si-IV-O-Al-IV (II), respectively. These sites may stem from crystallographically distinct Si-IV-O-Al-IV sites of varying bond length and Si-IV-O-Al-VI bond angle or Al-IV-O-2(VI)Al site in the montmorillonite. C1 [Lee, Sung Keun] Seoul Natl Univ, Sch Earth & Environm Sci, Seoul 151742, South Korea. [Weiss, Charles A., Jr.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lee, SK (reprint author), Seoul Natl Univ, Sch Earth & Environm Sci, Seoul 151742, South Korea. EM sungklee@snu.ac.kr NR 34 TC 5 Z9 5 U1 4 U2 20 PU MINERALOGICAL SOC AMER PI CHANTILLY PA 3635 CONCORDE PKWY STE 500, CHANTILLY, VA 20151-1125 USA SN 0003-004X EI 1945-3027 J9 AM MINERAL JI Am. Miner. PD JUL PY 2008 VL 93 IS 7 BP 1066 EP 1071 DI 10.2138/am.2008.2743 PG 6 WC Geochemistry & Geophysics; Mineralogy SC Geochemistry & Geophysics; Mineralogy GA 323DB UT WOS:000257423100013 ER PT J AU Stratis-Cullum, DN Griffin, GD Mobley, J Vo-Dinh, T AF Stratis-Cullum, Dimitra N. Griffin, Guy D. Mobley, Joel Vo-Dinh, Tuan TI Intensified biochip system using chemiluminescence for the detection of Bacillus globigii spores SO ANALYTICAL AND BIOANALYTICAL CHEMISTRY LA English DT Article DE biochips; biosensors immunoassays; ELISA; spectroscopy; Bacillus globigii; chemiluminescence; spores; intensifier; bioluminescence ID FIBER-OPTIC BIOSENSOR; IMMUNOASSAYS AB This paper reports the first intensified biochip system for chemiluminescence detection and the feasibility of using this system for the analysis of biological warfare agents is demonstrated. An enzyme-linked immunosorbent assay targeting Bacillus globigii spores, a surrogate species for Bacillus anthracis, using a chemiluminescent alkaline phosphatase substrate is combined with a compact intensified biochip detection system. The enzymatic amplification was found to be an attractive method for detection of low spore concentrations when combined with the intensified biochip device. This system was capable of detecting approximately 1 x 10(5) Bacillus globigii spores. Moreover, the chemiluminescence method, combined with the self-contained biochip design, allows for a simple, compact system that does not require laser excitation and is readily adaptable to field use. C1 [Stratis-Cullum, Dimitra N.] USA, Res Lab, AMSRD ARL SE EO, Adelphi, MD 20783 USA. [Griffin, Guy D.; Vo-Dinh, Tuan] Duke Univ, Fitzpatrick Inst Photon, Dept Biomed Engn, Durham, NC 27708 USA. [Griffin, Guy D.; Vo-Dinh, Tuan] Duke Univ, Fitzpatrick Inst Photon, Dept Chem, Durham, NC 27708 USA. [Mobley, Joel] Univ Mississippi, Dept Phys & Astron, Oxford, MS 38677 USA. RP Stratis-Cullum, DN (reprint author), USA, Res Lab, AMSRD ARL SE EO, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dimitra.stratiscullum1@us.army.mil; tuan.vodinh@duke.edu NR 20 TC 7 Z9 7 U1 1 U2 10 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1618-2642 J9 ANAL BIOANAL CHEM JI Anal. Bioanal. Chem. PD JUL PY 2008 VL 391 IS 5 BP 1655 EP 1660 DI 10.1007/s00216-008-1835-0 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 315VL UT WOS:000256908200018 PM 18224472 ER PT J AU Keener, WK Rivera, VR Cho, CY Hale, ML Garber, EAE Poli, MA AF Keener, William K. Rivera, Victor R. Cho, Chung Y. Hale, Martha L. Garber, Eric A. E. Poli, Mark A. TI Identification of the RNA N-glycosidase activity of ricin in castor bean extracts by an electrochemiluminescence-based assay SO ANALYTICAL BIOCHEMISTRY LA English DT Article AB A simple electrochemiluminescence-based assay for RNA N-glycosidase activity has been modified to permit its use with authentic extracts of Ricinus communis (castor beans) and Abrus precatorius (jequirity seeds)-the natural sources of ricin and abrin. Modifications include the addition of an RNase inactivator to the reaction mixture, elimination of a signal-enhancing monoclonal antibody, and optimization of the incubation temperature. Concurrent testing with two substrates provides a diagnostic too] enabling castor bean toxins to be differentiated from a larger selection of N-glycosidase toxins than was previously examined. (c) 2008 Published by Elsevier Inc. C1 [Keener, William K.; Rivera, Victor R.; Hale, Martha L.; Poli, Mark A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Cho, Chung Y.; Garber, Eric A. E.] US FDA, College Pk, MD 20740 USA. RP Keener, WK (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM william.keener@us.army.mil; mark.poli@us.army.mil NR 4 TC 6 Z9 6 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD JUL 1 PY 2008 VL 378 IS 1 BP 87 EP 89 DI 10.1016/j.ab.2008.03.019 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 309LQ UT WOS:000256462300013 PM 18394420 ER PT J AU Grathwohl, KW Black, IH Spinella, PC Sweeney, J Robalino, J Helminiak, J Grimes, J Gullick, R Wade, CE AF Grathwohl, Kurt W. Black, Ian H. Spinella, Phillip C. Sweeney, Jason Robalino, Joffre Helminiak, Joseph Grimes, Jamie Gullick, Richard Wade, Charles E. TI Total intravenous anesthesia including ketamine versus volatile gas anesthesia for combat-related operative traumatic brain injury SO ANESTHESIOLOGY LA English DT Article ID CEREBRAL-BLOOD-FLOW; WARTIME NEUROSURGICAL EXPERIENCE; GLASGOW OUTCOME SCALE; INTRACRANIAL-PRESSURE; CRANIOCEREBRAL INJURIES; SEVOFLURANE ANESTHESIA; PROPOFOL ANESTHESIA; PERFUSION-PRESSURE; OXYGEN-CONSUMPTION; HEMORRHAGIC-SHOCK AB Background: Traumatic brain injury is a leading cause of death and severe neurologic disability. The effect of anesthesia techniques on neurologic outcomes in traumatic brain injury and potential benefits of total intravenous anesthesia (TIVA) compared with volatile gas anesthesia (VGA), although proposed, has not been well evaluated. The purpose of this study was to compare TIVA versus VGA in patients with combat-related traumatic brain injury. Methods: The authors retrospectively reviewed 252 patients who had traumatic brain injury and underwent operative neurosurgical intervention. Statistical analyses, including propensity score and matched analyses, were performed to assess differences between treatment groups (TWA vs. VGA) and good neurologic outcome. Results: Two hundred fourteen patients met inclusion criteria and were analyzed; 120 received VGA and 94 received TIVA. Good neurologic outcome (Glasgow Outcome Score 4-5) and decreased mortality were associated with TIVA compared with VGA (75% vs. 54%; P = 0.002 and 5% vs. 16%; P = 0.02, respectively). Multivariate logistic regression found admission Glasgow Coma Scale score of 8 or greater (odds ratio, 13.3; P < 0.001) and TIVA use (odds ratio, 2.3; P = 0.05) to be associated with good neurologic outcomes. After controlling for confounding factors using propensity analysis and repeated one-to-one matching of patients receiving TIVA with those receiving VGA with regard to Injury Severity Score, Glasgow Coma Scale score, base deficit, Head Abbreviated injury Score, and craniectomy or craniotomy, the authors could not find an association between treatment and neurologic outcome. Conclusion: Total intravenous anesthesia often including ketamine was not associated with improved neurologic outcome compared with VGA. Multiple confounders limit conclusions that can be drawn from this retrospective study. C1 [Grathwohl, Kurt W.] Brooke Army Med Ctr, Div Anesthesiol Crit Care Med, San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX 78234 USA. [Grathwohl, Kurt W.] Univ Texas Hlth Sci Ctr San Antonio, Trauma Div, San Antonio, TX USA. [Black, Ian H.] Uniformed Serv Univ Hlth Sci, Brooke Army Med Ctr, TARGIT, Bethesda, MD 20814 USA. [Spinella, Phillip C.] Connecticut Childrens Med Ctr, Hartford, CT USA. [Sweeney, Jason] Elmendorf AF Base, Anchorage, AK USA. [Robalino, Joffre] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Helminiak, Joseph] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Grimes, Jamie] Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Program Director Transit Year, San Antonio, TX USA. [Wade, Charles E.] USA, Inst Surg Res, San Antonio, TX USA. Brooke Army Med Ctr, TARGIT, Div Anesthesiol Crit Care Med, Dept Anesthesia & Operat Services, San Antonio, TX USA. RP Grathwohl, KW (reprint author), Brooke Army Med Ctr, Div Anesthesiol Crit Care Med, San Antonio Uniformed Serv Hlth Educ Consortium, Bldg 3600,3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM kurt.grathwohl@amedd.army.mil NR 54 TC 12 Z9 14 U1 4 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-3022 EI 1528-1175 J9 ANESTHESIOLOGY JI Anesthesiology PD JUL PY 2008 VL 109 IS 1 BP 44 EP 53 PG 10 WC Anesthesiology SC Anesthesiology GA 319AX UT WOS:000257135300008 PM 18580171 ER PT J AU Ellsworth, RE Ellsworth, DL Patney, HL Deyarmin, B Hooke, JA Love, B Shriver, CD AF Ellsworth, Rachel E. Ellsworth, Darrell L. Patney, Heather L. Deyarmin, Brenda Hooke, Jeffrey A. Love, Brad Shriver, Craig D. TI Genomic alterations associated with early stages of breast tumor metastasis SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article; Proceedings Paper CT 61st Annual Cancer Symposium of the Society-of-Surgical-Oncology CY MAR 13-16, 2008 CL Chicago, IL SP Soc Surg Oncol DE allelic imbalance; primary breast tumor; metastasis ID C-MYC; CANCER METASTASIS; LYMPH-NODE; GENETIC-HETEROGENEITY; CLONAL EVOLUTION; PROTO-ONCOGENES; CARCINOMA; CELLS; EXPRESSION; HETEROZYGOSITY AB Background: Molecular studies suggest that acquisition of metastatic potential occurs early in the development of breast cancer; mechanisms by which cells disseminate from the primary carcinomas and successfully colonize foreign tissues are, however, largely unknown. Thus, we examined levels and patterns of chromosomal alterations in primary breast tumors from node-negative (n = 114) and node-positive (n = 115) patients to determine whether specific genomic changes are associated with tumor metastasis. Methods: Fifty-two genetic markers representing 26 chromosomal regions commonly altered in breast cancer were examined in laser microdissected tumor samples to assess levels and patterns of allelic imbalance (AI). Real time-PCR (RT-PCR) was performed to determine expression levels of candidate genes. Data was analyzed using exact unconditional and Student's t-tests with significance values of P < 0.05 and P < 0.002 used for the clinicopathological and genomic analyses, respectively. Results: Overall levels of AI in primary breast tumors from node-negative (20.8%) and node-positive (21.9%) patients did not differ significantly (P = 0.291). When data were examined by chromosomal region, only chromosome 8q24 showed significantly higher levels (P < 0.0005) of AI in node-positive primary tumors (23%) versus node-negative samples (6%). c-MYC showed significantly higher levels of gene expression in primary breast tumors from patients with lymph node metastasis. Conclusions: Higher frequencies of AI at chromosome 8q24 in patients with positive lymph nodes suggest that genetic changes in this region are important to the process of metastasis. Because overexpression of c-MYC has been associated with cellular dissemination as well as development of the premetastatic niche, alterations of the 8q24 region, including c-MYC, may be key determinants in the development of lymph node metastasis. C1 [Ellsworth, Rachel E.] Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, Windber, PA 15963 USA. [Ellsworth, Rachel E.; Ellsworth, Darrell L.; Patney, Heather L.; Deyarmin, Brenda] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. [Love, Brad] Invitrogen, Carlsbad, CA 92008 USA. RP Ellsworth, RE (reprint author), Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org NR 39 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD JUL PY 2008 VL 15 IS 7 BP 1989 EP 1995 DI 10.1245/s10434-008-9902-5 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA 320GY UT WOS:000257222900024 PM 18401664 ER PT J AU Henry, LR Solomon, NP Howard, R Gurevich-Uvena, J Horst, LB Coppit, G Orlikoff, R Libutti, SK Shaha, AR Stojadinovic, A AF Henry, Leonard R. Solomon, Nancy Pearl Howard, Robin Gurevich-Uvena, Joyce Horst, Leah B. Coppit, George Orlikoff, Robert Libutti, Steven K. Shaha, Ashok R. Stojadinovic, Alexander TI The functional impact on voice of sternothyroid muscle division during thyroidectomy SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE sternothyroid; voice; thyroidectomy ID SUPERIOR LARYNGEAL NERVE; EXTERNAL BRANCH; SURGERY; IDENTIFICATION; DISEASE; INJURY AB Background: Post-thyroidectomy voice dysfunction may occur in the absence of laryngeal nerve injury. Strap muscle division has been hypothesized as one potential contributor to dysphonia. Methods: Vocal-function data, prospectively recorded before and after thyroidectomy from two high-volume referral institutions, were utilized. Patient-reported symptoms, laryngoscopic, acoustic, and aerodynamic parameters were recorded at 2 weeks and 3 months postoperatively. Patients with and without sternothyroid muscle division during surgery were compared for voice changes. Patients with laryngeal nerve injury, sternohyoid muscle division, arytenoid subluxation or no early postoperative follow-up evaluation were excluded. Differences between study groups and outcomes were compared using t-tests and rank-sum tests as appropriate. Results: Of 84 patients included, 45 had sternothyroid division. Distribution of age, gender, extent of thyroidectomy, specimen size, and laryngeal nerve identification rates did not differ significantly between groups. There was a significant predilection for or against sternothyroid muscle division according to medical center. No significant difference in reported voice symptoms was observed between groups 2 weeks or 3 months after thyroidectomy. Likewise, acoustic and aerodynamic parameters did not differ significantly between groups at these postoperative study time points. Conclusion: Sternothyroid muscle division is occasionally employed during thyroidectomy to gain superior pedicle exposure. Division of this muscle does not appear to be associated with adverse functional voice outcome, and should be utilized at surgeon discretion during thyroidectomy. C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Stojadinovic, Alexander] USA, Mil Canc Inst, Washington, DC 20307 USA. [Henry, Leonard R.] USN, Med Ctr, Dept Surg, Div Surg Oncol, Bethesda, MD 20889 USA. [Solomon, Nancy Pearl; Gurevich-Uvena, Joyce] Walter Reed Army Med Ctr, Dept Surg, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Howard, Robin] Walter Reed Army Med Ctr, Dept Clin Invest, Div Biostat, Washington, DC 20307 USA. [Horst, Leah B.] Walter Reed Army Med Ctr, Dept Surg, Div Anesthesia, Washington, DC 20307 USA. [Coppit, George] Walter Reed Army Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. [Orlikoff, Robert] Seton Hall Univ, Dept Speech Language Pathol, S Orange, NJ 07079 USA. [Libutti, Steven K.] Natl Canc Inst, Surg Branch, Bethesda, MD 20889 USA. [Shaha, Ashok R.] Mem Sloan Kettering Canc Ctr, Dept Surg Oncol, Head & Neck Serv, New York, NY 10021 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Alexander.stojadinovic@na.amedd.army.mil OI Orlikoff, Robert/0000-0003-0048-6541 NR 24 TC 25 Z9 25 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD JUL PY 2008 VL 15 IS 7 BP 2027 EP 2033 DI 10.1245/s10434-008-9936-8 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA 320GY UT WOS:000257222900029 PM 18459003 ER PT J AU Mulligan, CR Tavaf-Motamen, H Stewart, R Devries, WC AF Mulligan, Charles R., Jr. Tavaf-Motamen, Houman Stewart, Robert Devries, William C. TI Chondrosarcoma masquerading as cardiomyopathy SO ANNALS OF THORACIC SURGERY LA English DT Editorial Material ID ACQUIRED PULMONIC STENOSIS; CARDIAC COMPRESSION AB A 17-year-old male patient presented to his primary care provider with heart failure symptoms and was transferred to our hospital with the diagnosis of idiopathic cardiomyopathy. His workup identified a large mediastinal mass with right ventricular outflow obstruction, which was resected. The pathology of the mass was a low-grade chondrosarcoma. The patient currently remains disease free at 4 years. C1 [Mulligan, Charles R., Jr.] Walter Reed Army Med Ctr, Dept Surg, Div Cardiothorac Surg, Washington, DC 20307 USA. RP Mulligan, CR (reprint author), Walter Reed Army Med Ctr, Dept Surg, Div Cardiothorac Surg, Rm 4655,6900 Georgia Ave NW, Washington, DC 20307 USA. EM charles.mulligan@us.army.mil NR 6 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD JUL PY 2008 VL 86 IS 1 BP 297 EP 299 DI 10.1016/j.athoracsur.2008.01.068 PG 4 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA 316FK UT WOS:000256934400048 PM 18573445 ER PT J AU Louie, A Heine, HS Kim, K Brown, DL VanScoy, B Liu, W Kinzig-Schippers, M Sorgel, F Drusanol, GL AF Louie, A. Heine, H. S. Kim, K. Brown, D. L. VanScoy, B. Liu, W. Kinzig-Schippers, M. Soergel, F. Drusanol, G. L. TI Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID STAPHYLOCOCCUS-AUREUS; INHALATIONAL ANTHRAX; TOXIN PRODUCTION; UNITED-STATES/; BIOTERRORISM; EFFICACY; THERAPY; LEVOFLOXACIN; CLINDAMYCIN; INFECTIONS AB Simulating the average non-protein-bound (free) human serum drug concentration-time profiles for linezolid in an in vitro pharmacodynamic model, we characterized the pharmacodynamic parameter(s) of linezolid predictive of kill and for prevention of resistance in Bacillus anthracis. In 10-day dose-ranging studies, the average exposure for >= 700 mg of linezolid given once daily (QD) resulted in > 3-log CFU/ml declines in B. anthracis without resistance selection. Linezolid at <= 600 mg QD amplified for resistance. With twice-daily (q12h) dosing, linezolid at >= 500 mg q12h was required for resistance prevention. In dose fractionation studies, killing of B. anthracis was predicted by the area under the time-concentration curve (AUC)/MIC ratio. However, resistance prevention was linked to the maximum serum drug concentration (C-max)/MIC ratio. Monte Carlo simulations predicted that linezolid at 1,100 mg QD would produce in 96.7% of human subjects a free 24-h AUC that would match or exceed the average 24-h AUC of 78.5 mg . h/liter generated by linezolid at 700 mg QD while reproducing the shape of the concentration-time profile for this pharmacodynamically optimized regimen. However, linezolid at 700 mg q12h (cumulative daily dose of 1,400 mg) would produce an exposure that would equal or exceed the average free 24-h AUC of 90 mg . h/liter generated by linezolid at 500 mg q12h in 93.8% of human subjects. In conclusion, in our in vitro studies, the QD-administered, pharmacodynamically optimized regimen for linezolid killed drug-susceptible B. anthracis and prevented resistance emergence at lower dosages than q12h regimens. The lower dosage for the pharmacodynamically optimized regimen may decrease drug toxicity. Also, the QD administration schedule may improve patient compliance. C1 [Louie, A.; Kim, K.; Brown, D. L.; VanScoy, B.; Liu, W.; Drusanol, G. L.] Ordway Res Inst, Albany, NY 12208 USA. [Heine, H. S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kinzig-Schippers, M.; Soergel, F.] Inst Biomed & Pharmaceut Res, Nurnberg, Germany. RP Louie, A (reprint author), Ordway Res Inst, 150 New Scotland Ave, Albany, NY 12208 USA. EM alouie@ordwayresearch.org FU NIAID NIH HHS [P01AI060908, P01 AI060908] NR 38 TC 25 Z9 25 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2008 VL 52 IS 7 BP 2486 EP 2496 DI 10.1128/AAC.01439-07 PG 11 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 319SE UT WOS:000257183400029 PM 18458134 ER PT J AU Chung, DH Kumarapperuma, SC Sun, YJ Li, QJ Chu, YK Arterburn, JB Parker, WB Smith, J Spik, K Ramanathan, HN Schmaljohn, CS Jonsson, CB AF Chung, Dong-Hoon Kumarapperuma, Sidath C. Sun, Yanjie Li, Qianjun Chu, Yong-Kyu Arterburn, Jeffrey B. Parker, William B. Smith, Jeffrey Spik, Kristin Ramanathan, Harish N. Schmaljohn, Connie S. Jonsson, Colleen B. TI Synthesis Of 1-beta-D-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus SO ANTIVIRAL RESEARCH LA English DT Article DE hemorrhagic fever with renal syndrome; HFRS; Hantaan virus HTNV; Andes virus; ribavirin; Crimean Congo hemorrhagic fever virus; Rift Valley fever virus ID TO-PERSON TRANSMISSION; MOUSE PEROMYSCUS-MANICULATUS; SIN NOMBRE HANTAVIRUS; PULMONARY SYNDROME; HANTAAN VIRUS; HEMORRHAGIC-FEVER; INTRAVENOUS RIBAVIRIN; RENAL SYNDROME; EXPERIMENTAL-INFECTION; IMP DEHYDROGENASE AB There are no FDA approved drugs for the treatment of hemorrhagic fever with renal syndrome (HFRS), a serious human illnesses caused by hantaviruses. Clinical studies using ribavirin (RBV) to treat HFRS patients suggest that it provides an improved prognosis when given early in the course of disease. Given the unique antiviral activity of RBV and the lack of other lead scaffolds, we prepared a diverse series of 3-substituted 1,2,4-triazole-beta-ribosides and identified one with antiviral activity, 1-beta-D-ribofuranosyl-3ethynyl-[ 1,2,4]triazole (ETAR). ETAR showed an EC50 value of 10 and 4.4 mu M for Hantaan virus (HTNV) and Andes virus, respectively. ETAR had weak activity against Crimean Congo hemorrhagic fever virus, but had no activity against Rift Valley fever virus. Intraperitoneally delivered ETAR offered protection to suckling mice challenged with HTNV with a similar to 25% survival at 12.5 and 25 mg/kg ETAR, and a MTD of 17.1 +/- 0.7 days. ETAR was phosphorylated in Vero E6 cells to its 5'-triphosphate and reduced cellular GTP levels. In contrast to RBV, ETAR did not increase mutation frequency of the HTNV genome, which suggests it has a different mechanism of action than RBV. ETAR is an exciting and promising lead compound that will be elaborated in further synthetic investigations as a framework for the rational design of new antivirals for treatment of HFRS. (c) 2008 Elsevier B.V. All rights reserved. C1 [Chung, Dong-Hoon; Sun, Yanjie; Li, Qianjun; Chu, Yong-Kyu; Parker, William B.; Jonsson, Colleen B.] So Res Inst, Dept Biochem & Mol Biol, Birmingham, AL 35205 USA. [Kumarapperuma, Sidath C.; Arterburn, Jeffrey B.] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA. [Smith, Jeffrey; Spik, Kristin; Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21703 USA. [Ramanathan, Harish N.] Univ Alabama, Dept Biochem, Birmingham, AL 35205 USA. RP Jonsson, CB (reprint author), So Res Inst, Dept Biochem & Mol Biol, 2000 9th Ave S, Birmingham, AL 35205 USA. EM Jonsson@sri.org RI RAMANATHAN, HARISH/B-1274-2013 OI RAMANATHAN, HARISH/0000-0001-6073-2981 FU NIAID NIH HHS [R21 AI064499-02, R21 AI064499, R21 AI 064499-01] NR 42 TC 23 Z9 26 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD JUL PY 2008 VL 79 IS 1 BP 19 EP 27 DI 10.1016/j.antiviral.2008.02.003 PG 9 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 305MB UT WOS:000256181400004 PM 18394724 ER PT J AU Peterson, C Park, N Sweeney, PJ AF Peterson, Christopher Park, Nansook Sweeney, Patrick J. TI Group well-being: Morale from a positive psychology perspective SO APPLIED PSYCHOLOGY-AN INTERNATIONAL REVIEW-PSYCHOLOGIE APPLIQUEE-REVUE INTERNATIONALE LA English DT Article ID ORGANIZATIONAL-BEHAVIOR; TEACHER MORALE; PERFORMANCE AB What makes life most worth living? The simplest summary of findings from the new field of positive psychology is that other people matter. It is within groups that we live, work, love, and play, and groups should therefore be a primary focus of researchers interested in health and well-being. In the present article, we propose morale as an important indicator of group well-being. We survey what is known about overall morale across a variety of groups: its meaning, measurement, enabling factors, and putative consequences. We sketch a future research agenda that would examine morale in multidimensional terms at both the individual and group levels and would pay particular attention to the positive outcomes associated with morale. C1 [Peterson, Christopher] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA. [Park, Nansook] Univ Rhode Isl, Kingston, RI 02881 USA. [Sweeney, Patrick J.] US Mil Acad, West Point, NY 10996 USA. RP Peterson, C (reprint author), Univ Michigan, Dept Psychol, 530 Church St, Ann Arbor, MI 48109 USA. EM chrispet@umich.edu NR 78 TC 14 Z9 15 U1 2 U2 20 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-994X J9 APPL PSYCHOL-INT REV JI Appl. Psychol.-Int. Rev.-Psychol. Appl.-Rev. Int. PD JUL PY 2008 VL 57 SU S BP 19 EP 36 DI 10.1111/j.1464-0597.2008.00352.x PG 18 WC Psychology, Applied SC Psychology GA 313VC UT WOS:000256767100003 ER PT J AU Charrow, A DiFazio, M Foster, L Pasquina, PF Tsao, JW AF Charrow, Alexandra DiFazio, Marc Foster, Leslie Pasquina, Paul F. Tsao, Jack W. TI Intradermal botulinum toxin type A injection effectively reduces residual limb hyperhidrosis in amputees: A case series SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Review DE amputation; botulinum toxin type A; hyperhidrosis; pain; phantom limb; rehabilitation ID AXILLARY HYPERHIDROSIS AB Objective: To study the effectiveness of botulinum toxin type A (BTX-A) therapy for residual limb hyperhidrosis, prosthesis fit and function, and residual and phantom limb pain in patients with limb amputation. Design: Consecutive case series. Setting: Outpatient physical medicine and rehabilitation clinic. Participants: Walter Reed Army Medical Center patients (N=8) with unilateral traumatic upper- or lower-limb amputation. Intervention: BTX-A was injected transdermally in a circumferential pattern around the residual limb by using a 1-cm matrix grid. Main Outcome Measure: A 10-cm continuous Likert visual analog scale was used to assess residual limb sweating and pain and prosthesis fit and function before and 3 weeks after BTX-A injections. Results: Patients reported a significant reduction in sweating and improvement in prosthesis fit and function after treatment. However, residual limb and phantom pain were unaffected by treatment. Conclusions: BTX-A may be an effective treatment for residual limb hyperhidrosis, resulting in subjective improvement in prosthesis fit and functioning. BTX-A should be considered as a method to manage excessive sweating in the residual limb of traumatic amputees. C1 [Charrow, Alexandra; Tsao, Jack W.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Charrow, Alexandra; Foster, Leslie; Pasquina, Paul F.] Walter Reed Army Med Ctr, Dept Phys Med & Rehabil, Washington, DC 20307 USA. [DiFazio, Marc] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. RP Tsao, JW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd,Room A1036, Bethesda, MD 20814 USA. EM jacktsao@earthlink.net NR 10 TC 12 Z9 13 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JUL PY 2008 VL 89 IS 7 BP 1407 EP 1409 DI 10.1016/j.apmr.2007.11.054 PG 3 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 323LK UT WOS:000257447400027 PM 18586144 ER PT J AU Cleland, JA Childs, JD Whitman, JM AF Cleland, Joshua A. Childs, John D. Whitman, Julie M. TI The psychometric properties of the Neck Disability Index - The authors respond SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Letter ID FUNCTIONAL SCALE; RATING-SCALE; PAIN; RESPONSIVENESS; QUESTIONNAIRE; RELIABILITY; VALIDATION; OUTCOMES; VERSION C1 [Cleland, Joshua A.] Franklin Pierce Univ, Dept Phys Therapy, Concord, NH USA. [Childs, John D.] Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. [Whitman, Julie M.] Regis Univ, Dept Phys Therapy, Denver, CO USA. RP Cleland, JA (reprint author), Franklin Pierce Univ, Dept Phys Therapy, Concord, NH USA. NR 11 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JUL PY 2008 VL 89 IS 7 BP 1415 EP 1416 DI 10.1016/j.apmr.2008.05.005 PG 2 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 323LK UT WOS:000257447400032 ER PT J AU Kelty, R AF Kelty, Ryan TI The US Navy's maiden voyage - Effects of integrating sailors and civilian mariners on deployment SO ARMED FORCES & SOCIETY LA English DT Article; Proceedings Paper CT Inter-University Seminar on Armed Forces and Society Biennial Meeting CY OCT 21-23, 2005 CL Chicago, IL DE military; navy; civilian; social comparisons; retention ID JOB-SATISFACTION; ORGANIZATIONAL COMMITMENT; NORMATIVE COMMITMENT; EMPLOYEE TURNOVER; MILITARY; CONSEQUENCES; METAANALYSIS; CONTINUANCE; ANTECEDENTS; INTENTIONS AB The U.S. federal government is increasingly civilianizing the military as a manpower-management strategy. Effects of this policy are not well understood. Data from a case study of civilian mariners integrated with sailors on a U.S. Navy ship were analyzed to determine the effects of social comparisons on each group's job satisfaction, organizational commitment, and intentions to remain with their current employer. Results indicate both sailors and civilian mariners view sailors as less advantaged compared to their civilian peers. The effect of these social comparisons on each group's satisfaction, commitment, and retention attitudes was mixed, having a significant negative impact for sailors but not for civilian mariners. These results identify an unintended negative consequence of the decision to integrate civilian and military personnel in an operational unit. The way civilian mariners were integrated is discussed as a possible reason for the differential effect of social comparisons between the two groups. C1 [Kelty, Ryan] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Kelty, R (reprint author), 646 Swift Rd, West Point, NY USA. EM ryan.kelty@usma.edu NR 67 TC 4 Z9 4 U1 1 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD JUL PY 2008 VL 34 IS 4 BP 536 EP 564 DI 10.1177/0095327X07312088 PG 29 WC Political Science; Sociology SC Government & Law; Sociology GA 316IR UT WOS:000256943400002 ER PT J AU Bonura, M AF Bonura, Michael TI The meaning of military victory SO ARMED FORCES & SOCIETY LA English DT Book Review C1 [Bonura, Michael] US Mil Acad, West Point, NY 10996 USA. RP Bonura, M (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD JUL PY 2008 VL 34 IS 4 BP 714 EP 716 DI 10.1177/0095327X07307988 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA 316IR UT WOS:000256943400009 ER PT J AU Frey, DS AF Frey, David S. TI Amateur photographer SO ARMED FORCES & SOCIETY LA English DT Book Review C1 [Frey, David S.] US Mil Acad, West Point, NY 10996 USA. RP Frey, DS (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD JUL PY 2008 VL 34 IS 4 BP 719 EP 721 DI 10.1177/0095327X07313627 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA 316IR UT WOS:000256943400011 ER PT J AU Kim, H Soibelman, L Grobler, F AF Kim, Hyunioo Soibelman, Lucio Grobler, Francois TI Factor selection for delay analysis using Knowledge Discovery in Databases SO AUTOMATION IN CONSTRUCTION LA English DT Article DE knowledge Discovery in Databases; construction delay; statistics; machine learning; factor selection ID CONSTRUCTION; EXAMPLE AB Today's construction project has become a very complex, high-risk, multiparty endeavor. Construction projects are composed of many interrelated elements of labor, cost, material, schedule, and other resources, making it difficult to discern which factors were the main causes for delay on a given project. Were all relevant factors to be considered, it would become an overwhelming task. On the other hand, it would be very difficult to know on which factors to focus if only a limited number of factors were to be considered. This paper presents a methodology for factor selection; identifying which factors in an on-going construction project contribute most to the experienced delays. Factor selection is defined as the process of finding relevant factors among a large set of original attributes with the objective of best representing the original dataset and utilizes Knowledge Discovery in Databases (KDD), which is a data analysis process to discover useful knowledge in a large database. A specific construction project has been analyzed to identify main factors of construction delays through the process of statistical measurements and machine learning algorithms. (C) 2007 Elsevier B.V. All rights reserved. C1 [Kim, Hyunioo; Grobler, Francois] USA, Engineer Res & Dev Ctr, Champaign, IL 61826 USA. [Soibelman, Lucio] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. RP Kim, H (reprint author), USA, Engineer Res & Dev Ctr, POB 9005, Champaign, IL 61826 USA. EM hyunjoo.kim@erdc.usace.army.mil NR 34 TC 9 Z9 12 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-5805 J9 AUTOMAT CONSTR JI Autom. Constr. PD JUL PY 2008 VL 17 IS 5 BP 550 EP 560 DI 10.1016/j.autcon.2007.10.001 PG 11 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 300TN UT WOS:000255848200004 ER PT J AU Rickards, CA Ryan, KL Cooke, WH Romero, SA Convertino, VA AF Rickards, Caroline A. Ryan, Kathy L. Cooke, William H. Romero, Steven A. Convertino, Victor A. TI Combat stress or hemorrhage? Evidence for a decision-assist algorithm for remote triage SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE heart rate variability; pulse pressure; military triage; remote monitoring ID HEART-RATE-VARIABILITY; BODY NEGATIVE-PRESSURE; CENTRAL HYPOVOLEMIA; SPECTRAL-ANALYSIS; AUTONOMIC FUNCTION; TRAUMA PATIENTS; RESPONSES; EXERCISE; HUMANS; ASSOCIATION AB Introduction: In the setting of remote military triage, when physical access to the patient is not possible, traditional physiological measurements available to a combat medic may not differentiate between a wounded soldier and an active soldier. We tested the hypothesis that changes in high-frequency R-R interval spectral power (RRI HF) and pulse pressure (PP) would differ between progressive central hypovolemia (simulated hemorrhage) and exercise to evaluate their potential for remotely distinguishing active from bleeding soldiers. The RRI HF and PP were used because of their ability to track central hypovolemia. Methods: There were 12 (8 female/4 male) healthy, normotensive, nonsmoking subjects (age 2 7 +/- 2 yr; height 169 +/- 13 cm; weight 68 +/- 5 kg) who were exposed to progressive lower body negative pressure (LBNP) and a supine cycle ergometer protocol. ECG and blood pressure were measured continuously. Exercise workloads were determined by matching the heart rate (HR) responses to each LBNP level. Data were analyzed in time and frequency domains. Results: FIR increased from 67 +/- 3 bpm at rest to 101 +/- 4 bpm by -60 mmHg LBNP and was matched within 5% during exercise. By the final stage, RRI HF decreased by a similar magnitude during both LBNP (-78 +/- 7%) and exercise (-85 +/- 6%). PP decreased by 30 +/- 4% with LBNP compared with an increase of 20 +/- 6% during exercise. Conclusion: Monitoring PP in combination with RRI HF would distinguish a bleeding from an active soldier. Technologies that incorporate telemetry to track these derived vital signs would provide a combat medic with remote decision support to assess soldier status on the battlefield. C1 [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cooke, William H.; Romero, Steven A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. RP Rickards, CA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM caroline.rickards@us.army.mil NR 34 TC 11 Z9 11 U1 0 U2 4 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2008 VL 79 IS 7 BP 670 EP 676 DI 10.3357/ASEM.2223.2008 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 320XQ UT WOS:000257268900004 PM 18619126 ER PT J AU Knapik, JJ Spiess, A Swedler, D Grier, T Darakjy, S Amoroso, P Jones, BH AF Knapik, Joseph J. Spiess, Anita Swedler, David Grier, Tyson Darakjy, Salima Amoroso, Paul Jones, Bruce H. TI Injury risk factors in parachuting and acceptability of the parachute ankle brace SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE age; height; weight; push-ups; physical fitness; aerobic fitness; prior injury ID PHYSICAL-FITNESS; LANDING INJURIES; ARMY; EPIDEMIOLOGY; BATTALION; ALTITUDE; SOLDIERS; RUNNERS; WEIGHT; HEIGHT AB Introduction: This investigation examined risk factors for injuries during military parachute training and solicited attitudes and opinions regarding a parachute ankle brace (PAB) that has been shown to protect against ankle injuries. Methods: Male Army airborne students (N = 1677) completed a questionnaire after they had successfully executed 4 of the 5 jumps necessary for qualification as a military paratrooper. The questionnaire asked about injuries during parachute descents, demographics, lifestyle characteristics, physical characteristics, physical fitness, airborne recycling (i.e., repeating airborne training because of failure to qualify on a previous attempt), PAB wear, problems with aircraft exits, and injuries in the year before airborne school. A final section of the questionnaire solicited open-ended comments about the PAB. Results: Increased risk of a parachute-related injury occurred among students who had longer time in service, were older, taller, heavier, performed fewer push-ups, ran slower, were airborne recycles, did not wear the PAB, had an aircraft exit problem, and/or reported an injury in the year prior to jump school. Among students who wore the brace, most negative comments about the PAB had to do with design, comfort, and difficulties during parachute landing falls. Conclusions: This study supported some previously identified injury risk factors (older age, greater body weight, and not using a PAB) and identified a number of new risk factors. To address PAB design and comfort issues, a strap is being added over the dorsum of the foot to better hold the PAB in place. C1 [Knapik, Joseph J.; Spiess, Anita; Swedler, David; Grier, Tyson; Darakjy, Salima; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. [Amoroso, Paul] Madigan Army Med Ctr, Dept Clin Invest, Tacoma, WA USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, 1570 Stark Rd, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@apg.amedd.army.mil NR 30 TC 11 Z9 13 U1 0 U2 4 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2008 VL 79 IS 7 BP 689 EP 694 DI 10.3357/ASEM.2273.2008 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 320XQ UT WOS:000257268900007 PM 18619129 ER PT J AU Clough, C Padovani, M AF Clough, Charles Padovani, Michael TI OBSERVATIONS UPPER-AIR MOISTURE DATA VOID DISCOVERED ... AND PARTIALLY RECTIFIED SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Editorial Material C1 [Padovani, Michael] USA, Aberdeen Test Ctr, Attn Atmospher Effects Team, Aberdeen Proving Ground, MD 21005 USA. RP Padovani, M (reprint author), USA, Aberdeen Test Ctr, Attn Atmospher Effects Team, 400 Colleran Rd, Aberdeen Proving Ground, MD 21005 USA. EM michael.padovani@us.army.mil NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD JUL PY 2008 VL 89 IS 7 BP 953 EP 956 DI 10.1175/2007BAMS2463.1 PG 4 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 439GD UT WOS:000265614700001 ER PT J AU Kuz'min, VE Muratov, EN Artemenko, AG Gorb, L Qasim, M Leszczynski, J AF Kuz'min, V. E. Muratov, E. N. Artemenko, A. G. Gorb, L. Qasim, M. Leszczynski, J. TI The effect of nitroaromatics' composition on their toxicity in vivo: Novel, efficient non-additive 1D QSAR analysis SO CHEMOSPHERE LA English DT Article DE QSAR; toxicity in vivo; nitroaromatic compounds; SiRMS ID SIMPLEX REPRESENTATION; QUANTITATIVE STRUCTURE; MOLECULAR-STRUCTURE; VARIABLE SELECTION; BASE; PLS; DERIVATIVES; PREDICTION AB Novel 1D QSAR approach that allows analysis of non-additive effects of molecular fragments on toxicity has been proposed. Twenty-eight nitroaromatic compounds including some well-known explosives have been chosen for this study. The 50% lethal dose concentration for rats (LD50) was used as the estimation of toxicity in vivo to develop 1D QSAR models on the framework of Simplex representation of molecular structure. The results of 1D QSAR analysis show that even the information about the composition of molecules provides the main trends of toxicity changes. The necessity of consideration of substituents' mutual impacts for the development of adequate QSAR models of nitroaromatics' toxicity was demonstrated. Statistic characteristics for all the developed partial least squares QSAR models, except the additive ones are quite satisfactory (R-2 = 0.81-0.92; Q(2)= 0.64-0.83; R-test(2) = 0.84-0.87). A successful performance of such models is due to their non-additivity i.e. possibility of taking into account the mutual influence of substituents in benzene ring which plays the governing role for toxicity change and could be mediated through the different C-H fragments of the ring. The correspondence between observed and predicted by these models toxicity values is good. This allowing combine advantages of such approaches and develop adequate consensus model that can be used as a toxicity virtual screening tool. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Kuz'min, V. E.; Muratov, E. N.; Gorb, L.; Leszczynski, J.] Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Kuz'min, V. E.; Muratov, E. N.; Artemenko, A. G.] Natl Acad Sci Ukraine, AV Bogatskii Inst Phys & Chem, Odessa, Ukraine. [Gorb, L.; Qasim, M.; Leszczynski, J.] USA, ERDC, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, 1400 JR Lynch St, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI Muratov, Eugene/C-4454-2014 OI Muratov, Eugene/0000-0003-4616-7036 NR 27 TC 35 Z9 35 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD JUL PY 2008 VL 72 IS 9 BP 1373 EP 1380 DI 10.1016/j.chemosphere.2008.04.045 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 335DM UT WOS:000258271000024 PM 18558419 ER PT J AU Taylor, AJ AF Taylor, Allen J. TI Given the ENHANCE trial results, ezetimibe is still unproven SO CLEVELAND CLINIC JOURNAL OF MEDICINE LA English DT Editorial Material ID DENSITY-LIPOPROTEIN CHOLESTEROL; C-REACTIVE PROTEIN; ENDOTHELIAL FUNCTION; FAMILIAL HYPERCHOLESTEROLEMIA; SCAVENGER RECEPTOR; STATIN THERAPY; SR-BI; SIMVASTATIN; DISEASE; ABSORPTION C1 [Taylor, Allen J.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. [Taylor, Allen J.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Taylor, Allen J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave NW,Bldg 2,Room 4A34, Washington, DC 20307 USA. EM allen.taylor@na.amedd.army.mil NR 21 TC 4 Z9 4 U1 0 U2 0 PU CLEVELAND CLINIC PI CLEVELAND PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA SN 0891-1150 J9 CLEV CLIN J MED JI Clevel. Clin. J. Med. PD JUL PY 2008 VL 75 IS 7 BP 497 EP + PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 327WK UT WOS:000257759000007 PM 18646585 ER PT J AU Lentine, KL Rey, LAR Kolli, S Bacchi, G Schnitzler, MA Abbott, KC Xiao, HL Brennan, DC AF Lentine, Krista L. Rey, Lisa A. Rocca Kolli, Swathy Bacchi, Giuliana Schnitzler, Mark A. Abbott, Kevin C. Xiao, Huiling Brennan, Daniel C. TI Variations in the risk for cerebrovascular events after kidney transplant compared with experience on the waiting list and after graft failure SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article; Proceedings Paper CT 8th Annual State of the Art Winter Symposium of the American-Society-of-Transplant-Surgeons CY JAN 25-27, 2008 CL Marco Isl, FL SP Amer Soc Transplant Surg ID CONGESTIVE-HEART-FAILURE; ACUTE CORONARY SYNDROMES; STAGE RENAL-DISEASE; UNITED-STATES; MYOCARDIAL-INFARCTION; DIALYSIS PATIENTS; IMMUNOSUPPRESSION; PREDICTORS; OUTCOMES; STROKE AB Background and objectives: This study examined the risks, predictors, and mortality implications of cerebrovascular disease events after kidney transplantation in a national cohort. Design, setting, participants, & measurements: This analysis used United States Renal Data System registry data to study retrospectively Medicare-insured kidney transplant candidates (n = 51,304), recipients (n = 29,614), and recipients with allograft failure (n = 2954) in 1995 through 2002. New-onset cerebrovascular disease events including ischemic stroke, hemorrhagic stroke, and transient ischemic attacks were ascertained from billing records, and participants were followed until Medicare-end or December 31, 2002. Multivariable survival analysis was used to compare cerebrovascular disease event incidence and risk profiles among the study samples. Results: The cumulative, 3-yr incidence of de novo cerebrovascular disease events after transplantation was 6.8% and was lower than adjusted 3-yr estimates of 11.8% on the waiting list and 11.2% after graft loss. In time-dependent regression, transplantation predicted a 34% reduction in subsequent, overall cerebrovascular disease events risk compared with remaining on the waiting list, whereas risk for cerebrovascular disease events increased > 150% after graft failure. Similar relationships with transplantation and graft loss were observed for each type of cerebrovascular disease event. Smoking was a potentially preventable correlate of posttransplantation cerebrovascular disease events. Women were not protected. All forms of cerebrovascular disease event diagnoses after transplantation predicted increased mortality. Conclusions: Along with known benefits for cardiac complications, transplantation with sustained graft function seems to reduce risk for vascular disease events involving the cerebral circulation. C1 [Lentine, Krista L.; Rey, Lisa A. Rocca; Kolli, Swathy; Bacchi, Giuliana; Schnitzler, Mark A.; Xiao, Huiling] St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63104 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Div Nephrol, St Louis, MO 63104 USA. [Rey, Lisa A. Rocca] Univ Milan, Div Nephrol, San Paolo Hosp, Milan, Italy. [Bacchi, Giuliana] S Orsola Univ Hosp, Div Nephrol Dialysis & Transplantat, Bologna, Italy. [Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Brennan, Daniel C.] Washington Univ, Sch Med, Div Nephrol, St Louis, MO USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Sch Med, Salus Ctr 2nd Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentine.krista@stanfordalumni.org OI Abbott, Kevin/0000-0003-2111-7112 FU NIDDK NIH HHS [K08 DK073036, P30 DK079333, K08DK073036] NR 26 TC 25 Z9 26 U1 0 U2 1 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD JUL PY 2008 VL 3 IS 4 BP 1090 EP 1101 DI 10.2215/CJN.03080707 PG 12 WC Urology & Nephrology SC Urology & Nephrology GA 320UO UT WOS:000257260700024 PM 18385393 ER PT J AU Lentine, KL Schnitzler, MA Brennan, DC Snyder, JJ Hauptman, PJ Abbott, KC Axelrod, D Salvalaggio, PR Kasiske, B AF Lentine, Krista L. Schnitzler, Mark A. Brennan, Daniel C. Snyder, Jon J. Hauptman, Paul J. Abbott, Kevin C. Axelrod, David Salvalaggio, Paolo R. Kasiske, Bertram TI Cardiac evaluation before kidney transplantation: A practice patterns analysis in medicare-insured dialysis patients SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article; Proceedings Paper CT 8th Annual State of the Art Winter Symposium of the American-Society-of-Transplant-Surgeons CY JAN 25-27, 2008 CL Marco Isl, FL SP Amer Soc Transplant Surg ID STAGE RENAL-DISEASE; MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; HEART-DISEASE; CANDIDATES; PERFUSION AB Background and objectives: Evaluation for ischemic heart disease (IHD) is a nonstandardized practice before kidney transplantation. We retrospectively studied pretransplant cardiac evaluation (CE) practices in a national sample of renal allograft recipients. Design, setting, participants, & measurements: The USRDS data for Medicare beneficiaries transplanted in 1991 to 2004 with Part A&B benefits from dialysis initiation through transplantation were examined. Clinical traits defining "high" expected IHD risk were defined as diabetes, prior IHD, or >= 2 other coronary risk factors. Pretransplant CE were identified by billing claims for noninvasive stress tests and angiography. Patients were quantified with claims for coronary revascularization procedures between CE and transplant. Post-transplant acute myocardial infarction (AMI) events were abstracted from claims and death records. Results: Among 27,786 eligible patients, 46.3% underwent CE before transplantation. Overall, 9.5% who received CE also received pretransplant revascularization, but only 0.3% of lower-risk patients undergoing CE had revascularization. The adjusted odds of transplant without CE increased sharply with younger age and shorter dialysis duration. Increased likelihood of transplant without CE also correlated with black race, female sex, and certain geographic regions. Among patients transplanted without CE, 3-yr incidence of post-transplant AMI was 3% in lower-risk and 10% in high-risk groups, and varied by individual traits within these groups. Among lower-risk patients transplanted without CE, blacks were higher risk for AMI than whites (adjusted hazards ratio 1.47, 95% Cl 1.11-1.93). Conclusions: Observed practices demonstrate infrequent use of pretransplant revascularization after CE but also raise concern for socio-demographic barriers to evaluation access. C1 [Lentine, Krista L.; Schnitzler, Mark A.; Hauptman, Paul J.; Salvalaggio, Paolo R.] St Louis Univ, Sch Med, Ctr Outcomes Res, Salus Ctr, St Louis, MO 63104 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Div Nephrol, St Louis, MO 63104 USA. [Hauptman, Paul J.] St Louis Univ, Sch Med, Div Cardiol, St Louis, MO 63104 USA. [Brennan, Daniel C.] Washington Univ, Sch Med, Div Nephrol, St Louis, MO USA. [Snyder, Jon J.] Minneapolis Med Res Fdn Inc, Chron Dis Res Grp, Minneapolis, MN USA. [Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Axelrod, David] Dartmouth Hitchcock Med Ctr, Dept Surg, Hanover, NH USA. [Kasiske, Bertram] Univ Minnesota, Dept Nephrol, Minneapolis, MN USA. RP Lentine, KL (reprint author), St Louis Univ, Sch Med, Ctr Outcomes Res, Salus Ctr, 2nd Floor,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentine.krista@stanfordalumni.org OI Abbott, Kevin/0000-0003-2111-7112 FU NIDDK NIH HHS [K24 DK002886, K08 DK073036, K08DK073036, P30 DK079333, P30DK079333] NR 19 TC 24 Z9 24 U1 0 U2 3 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD JUL PY 2008 VL 3 IS 4 BP 1115 EP 1124 DI 10.2215/CJN.05351107 PG 10 WC Urology & Nephrology SC Urology & Nephrology GA 320UO UT WOS:000257260700026 PM 18417743 ER PT J AU Davison, JM Stocker, DJ Montilla-Soler, JL Jurgens, JS Allen, TW Holley, TS Stack, AL AF Davison, Jonathan M. Stocker, Derek J. Montilla-Soler, Jaime L. Jurgens, Jennifer S. Allen, Thomas W. Holley, Timothy S. Stack, Aaron L. TI The added benefit of a dedicated neck F-18 FDG PET-CT imaging protocol in patients with suspected recurrent differentiated thyroid carcinoma SO CLINICAL NUCLEAR MEDICINE LA English DT Article DE FDG; PET-CT; thyroid cancer; delayed imaging ID EMISSION-TOMOGRAPHY; MANAGEMENT; CANCER; PAPILLARY AB Purpose: To retrospectively analyze whether adding a delayed high-resolution dedicated neck F-18 FDG positron emission tomography-computerized tomographic (PET-CT) imaging protocol in patients with recurrent differentiated thyroid cancer increases the number of abnormal foci within the neck. Materials and Methods: Seventeen PET-CT studies from a total of 10 patients with suspected recurrent differentiated thyroid cancer between March 2003 and June 2004 were retrospectively reviewed. Each study included a whole body acquisition (WBA), followed by higher resolution dedicated neck acquisition (DNA). Two board-certified nuclear medicine physicians reviewed either the DNA or WBA for each study and recorded the number of abnormal foci, along with presence or absence of a soft tissue abnormality, and maximum standardized uptake value for each foci. Consensus review was used for all discrepancies. Statistical analysis was performed to determine whether there was a statistically significant increase in the number of studies demonstrating new abnormal foci with the addition of a DNA. Results: Five of 17 studies demonstrated an increase in the number of abnormal foci with the addition of the DNA (P < 0.04). A total of 8 abnormal foci were noted on the WBA, 4 of which were within the neck. Eleven additional abnormal foci were seen on the DNA. All abnormal foci within the neck had corresponding soft tissue abnormalities except for one. Conclusion: Adding a higher resolution delayed DNA to the WBA for patients undergoing PET-CT imaging to detect recurrent thyroid cancer increases the number of abnormal sites of FDG accumulation. C1 Walter Reed Army Med Ctr, Nucl Med Clin, Dept Radiol, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. RP Davison, JM (reprint author), Walter Reed Army Med Ctr, Nucl Med Clin, Dept Radiol, 6900 Georgia Ave, Washington, DC 20307 USA. EM jonathan.davison@gmail.com NR 13 TC 11 Z9 12 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD JUL PY 2008 VL 33 IS 7 BP 464 EP 468 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 318LV UT WOS:000257094100003 PM 18580230 ER PT J AU Kim, J Pratt, MJ Iyer, RG Sriram, RD AF Kim, Junhwan Pratt, Michael J. Iyer, Raj G. Sriram, Ram D. TI Standardized data exchange of CAD models with design intent SO COMPUTER-AIDED DESIGN LA English DT Article DE Data exchange; Design intent; CAD models; STEP; Construction history; Parameterization; Constraints ID CONSTRAINTS; SET AB Modern CAD systems-generate feature-based product shape models with parameterization and constraints. Until recently. standards for CAD data exchange among different CAD systems were restricted to the exchange of pure shape information. These standards ignored the construction history, parameters, constraints. features and other elements of design intent' present in the model to be transferred. This paper suggests an implementational foundation for CAD data exchange with the preservation of design intent, based on the use Of newly published parts of the International Standard ISO 10303 (STEP). Case studies are presented which employ a hypothetical STEP application protocol (AP) using Parts 55, 108 and 111 of ISO 10303. A prototype translator based on this AP has been implemented and tested. The paper reports on the experience gained in 'intelligent' data exchange. (C) 2008 Published by Elsevier Ltd C1 [Pratt, Michael J.] LMR Syst, Bedford MK43 7LA, England. [Kim, Junhwan; Sriram, Ram D.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Iyer, Raj G.] USA, TACOM, Warren, MI USA. RP Pratt, MJ (reprint author), LMR Syst, Bedford MK43 7LA, England. EM mike@lmr.clara.co.uk NR 28 TC 51 Z9 63 U1 0 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0010-4485 J9 COMPUT AIDED DESIGN JI Comput.-Aided Des. PD JUL PY 2008 VL 40 IS 7 SI SI BP 760 EP 777 DI 10.1016/j.cad.2007.06.014 PG 18 WC Computer Science, Software Engineering SC Computer Science GA 358LF UT WOS:000259917600004 ER PT J AU Lee, I Choi, KK Du, L Gorsich, D AF Lee, Ikjin Choi, K. K. Du, Liu Gorsich, David TI Dimension reduction method for reliability-based robust design optimization SO COMPUTERS & STRUCTURES LA English DT Article; Proceedings Paper CT 3rd European Conference on Computational Mechanics CY JUN 04-09, 2006 CL Natl Civil Engn Lab, Lisbon, PORTUGAL SP IACM, ECCOMAS, ECCSM, APMTAC, Fdn Sci & Technol, Calouste Gulbenkian Fdn, Tech Univ Lisbon, Inst Super Tecnico HO Natl Civil Engn Lab DE reliability-based robust design optimization (RBRDO); dimension reduction method (DRM); performance moment integration (PMI); percentile difference method (PDM); sensitivity analysis; statistical moment calculation ID INTEGRATION AB In reliability-based robust design optimization (RBRDO) formulation, the product quality loss function is minimized subject to probabilistic constraints. Since the quality loss function is expressed in terms of the first two statistical moments, mean and variance, three methods have been recently proposed to accurately and efficiently estimate the moments: the univariate dimension reduction method (DRM), performance moment integration (PMI) method, and percentile difference method (PDM). In this paper, a reliability-based robust design optimization method is developed using DRM and compared to PMI and PDM for accuracy and efficiency. The numerical results show that DRM is effective when the number of random variables is small, whereas PMI is more effective when the number of random variables is relatively large. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Lee, Ikjin; Choi, K. K.; Du, Liu] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52241 USA. [Gorsich, David] US Army RDECOM TARDEC AMSRD TAR N, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52241 USA. EM ilee@engineering.uiowa.edu; kkchoi@engineering.uiowa.edu; liudu@engineering.uiowa.edu; gorsichd@tacom.army.mil RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 NR 25 TC 60 Z9 72 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PD JUL PY 2008 VL 86 IS 13-14 BP 1550 EP 1562 DI 10.1016/j.compstruc.2007.05.020 PG 13 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA 317IK UT WOS:000257013100017 ER PT J AU Blackbourne, LH AF Blackbourne, Lorne H. TI Combat damage control surgery SO CRITICAL CARE MEDICINE LA English DT Review DE damage control; exploratory laparotomy; Operation Enduring Freedom; Operation Iraqi Freedom ID ABDOMINAL COMPARTMENT SYNDROME; CRITICALLY INJURED PATIENTS; PENETRATING TORSO INJURY; MULTIPLE ORGAN FAILURE; CONTROL LAPAROTOMY; TRAUMA PATIENTS; MISSED INJURIES; PREHOSPITAL INTERVENTIONS; FLUID RESUSCITATION; PLANNED REOPERATION AB Background: Although the use of damage control surgery for blunt and penetrating injury has been widely reported and defined, the use of damage control surgery on the battlefield (combat damage control surgery) has not been well detailed. Discussion. Damage control surgery is now well established as the standard of care for severely injured civilian patients requiring emergent laparotomy in the United States. The civilian damage control paradigm is based on a "damage control trilogy." This trilogy comprises an abbreviated operation, intensive care unit resuscitation, and a return to the operating room for the definitive operation. The goal of damage control surgery and the triology is avoidance of irreversible physiological insult termed the lethal triad The lethal triad comprises the vicious cycle of hypothermia, acidosis, and coagulopathy. Although the damage control model involves the damage control trilogy, abbreviated operation, intensive care unit resuscitation, and definitive operation, all in the same surgical facility, the combat damage control paradigm must incorporate global evacuation through several military surgical facilities and involves up to ten stages to allow for battlefield evacuation, surgical operations, multiple resuscitations, and transcontinental transport. Summary: Combat damage control surgery represents many unique challenges for those who care for the severely injured patients in a combat zone. C1 USA, Inst Surg Res, Brooke Army Med Ctr, Trauma Serv, Ft Sam Houston, TX 78234 USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, Trauma Serv, Ft Sam Houston, TX 78234 USA. EM lorne.blackbourne@amedd.army.mil NR 100 TC 48 Z9 53 U1 1 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S304 EP S310 DI 10.1097/CCM.0b013e31817e2854 PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700009 PM 18594257 ER PT J AU Carlton, PK Jenkins, DH AF Carlton, Paul K. Jenkins, Donald H. TI The mobile patient SO CRITICAL CARE MEDICINE LA English DT Editorial Material C1 [Jenkins, Donald H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Carlton, Paul K.] Texas A&M Univ Syst, Hlth Sci Ctr, College Stn, TX USA. RP Jenkins, DH (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM donald.jenkins@amedd.army.mil NR 1 TC 9 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S255 EP S257 DI 10.1097/CClM.0b013e31817da609 PG 3 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700002 PM 18594250 ER PT J AU Chung, KK Perkins, RM Oliver, JD AF Chung, Kevin K. Perkins, Robert M. Oliver, James D. TI Renal replacement therapy in support of combat operations SO CRITICAL CARE MEDICINE LA English DT Article DE renal replacement therapy; war; acute kidney failure; wounds and injuries; crush syndrome ID ACUTE KIDNEY INJURY; MILITARY CASUALTIES; FAILURE; DIALYSIS; INSUFFICIENCY; NEPHROLOGY; SURVIVAL AB Background: Renal replacement therapy has been used by the U.S. Army at the combat support hospital echelon of care since the Korean conflict. Although there has been a general decline in the incidence of wartime acute kidney injury, the mortality associated with acute kidney injury and the use of renal replacement therapy remain unchanged, in the range of 60% to 80%. The U.S. Army official doctrine is that field dialysis is provided through a specialized Hospital Augmentation Team; however, this team has not been deployed to either Iraq or Afghanistan as a result of the ability to rapidly evacuate most cases requiring renal replacement therapy. The history of wartime renal replacement therapy is reviewed along with the general epidemiology of battlefield acute kidney injury and renal replacement therapy. Discussion: Recent literature documents cases of renal replacement therapy performed in and out of theater in support of the current operations. In-theater renal replacement therapy has been provided through a variety of modalities, including conventional hemodialysis, peritoneal dialysis, and both continuous venovenous and continuous arteriovenous hemodialysis. Out of theater, casualties have received both intermittent and continuous hemodialysis at Landstuhl Regional Medical Center and Walter Reed Army Medical Center, whereas patients sustaining burns have undergone aggressive continuous venovenous hemofiltration or hemodiafiltration at Brooke Army Medical Center. Summary: Acute kidney injury requiring renal replacement therapy in wartime casualties is an uncommon occurrence but one with extremely high mortality. Future doctrine should be prepared for contingencies in which the incidence may be increased as a result of mass crush injury casualties or prolonged evacuation times. C1 [Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Perkins, Robert M.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Oliver, James D.] Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD USA. RP Chung, KK (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM kevin.chung@us.army.mil NR 21 TC 9 Z9 9 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S365 EP S369 DI 10.1097/CCM.0b013e31817e302a PG 5 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700016 PM 18594264 ER PT J AU Colombo, CJ Mount, CA Popa, CA AF Colombo, Christopher J. Mount, Cristin A. Popa, Christian A. TI Critical care medicine at Walter Reed Army Medical Center in support of the global war on terrorism SO CRITICAL CARE MEDICINE LA English DT Article DE military medicine; critical care; intensive care unit; military medical history; Acinetobacter; traumatic brain injury; intensive care; Walter Reed; trauma; posttraumatic stress disorder; history of Walter Reed Army Medical Center ID VENTILATOR-ASSOCIATED PNEUMONIA; MULTIDRUG-RESISTANT ACINETOBACTER; VENA-CAVAL FILTERS; VENOUS THROMBOEMBOLISM; PREVENTION; POSITION; INJURY; IRAQ AB Background. The military medical experience during wartime is unique and distinct from civilian medical practice. Historically, the military has produced innovations resulting in both civilian and military medical care advances, and our current conflict is no different. In this article, we provide a description of the medical and surgical intensive care units at Walter Reed, their history, and approach to new issues encountered in the care of Operation Iraqi Freedom and Operation Enduring Freedom soldiers. Additionally, descriptive statistics regarding the number of Operation Iraqi Freedom and Operation Enduring Freedom soldiers admitted to the critical care service, basic demographics, general category of injury, and discussion of intensive care unit issues unique to this patient population, such as Acinetobacter and traumatic brain injury, are presented. Discussion: We intend to provide a general description of our Operation Iraqi Freedom/Operation Enduring Freedom trauma population cared for by the critical care service at Walter Reed Army Medical Center, as well as a discussion of our approach to caring for some of their unique issues, to detail experiences that could translate into improvements for civilian trauma centers. C1 [Colombo, Christopher J.; Mount, Cristin A.; Popa, Christian A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Colombo, CJ (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM colombocj@aol.com OI Colombo, Christopher/0000-0001-5499-3368 NR 13 TC 6 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S388 EP S394 DI 10.1097/CCM.0b013e31817e3236 PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700020 PM 18594268 ER PT J AU Grathwohl, KW Venticinque, SG AF Grathwohl, Kurt W. Venticinque, Steven G. TI Organizational characteristics of the austere intensive care unit: The evolution of military trauma and critical care medicine, applications for civilian medical care systems SO CRITICAL CARE MEDICINE LA English DT Article DE critical care; intensive care; emergency mass critical care; US military; multidisciplinary critical care teams; intensive care unit organizations ID ILL PATIENTS; OUTCOMES; MORTALITY; EARTHQUAKE; INJURY AB Critical care in the U.S. military has significantly evolved in the last decade. More recently, the U.S. military has implemented organizational changes, including the use of multidisciplinary teams in austere environments to improve outcomes in severely injured polytrauma combat patients. Specifically, organizational changes in combat support hospitals located in combat zones during Operation Iraqi Freedom have led to decreased intensive care unit mortality and length of stay as well as resource use. These changes were implemented without increases in logistic support or the addition of highly technologic equipment. The mechanism for improvement in mortality is likely attributable to the adherence of basic critical care medicine fundamentals. This intensivist-directed team model provides sophisticated critical care even in the most austere environments. To optimize critically injured patients' outcomes, intensive care organizational models similar to the U.S. military, described in this article, can possibly be adapted to those of civilian care during disaster management to meet the challenges of emergency mass critical care. C1 [Grathwohl, Kurt W.] Univ Texas Hlth Sci Ctr San Antonio, Dept Anesthesia & Operat Serv, Div Anesthesiol & Crit Care Med,Trauma Div, Brooke Army Med Ctr,Dept Surg, San Antonio, TX 78229 USA. [Venticinque, Steven G.] Univ Texas Hlth Sci Ctr San Antonio, Audie L Murphy Mem Vet Adm Hosp, San Antonio, TX 78229 USA. [Venticinque, Steven G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, Trauma Div, San Antonio, TX 78229 USA. RP Grathwohl, KW (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Anesthesia & Operat Serv, Div Anesthesiol & Crit Care Med,Trauma Div, Brooke Army Med Ctr,Dept Surg, San Antonio, TX 78229 USA. EM kurt.grathwohl@amedd.army.mil NR 34 TC 18 Z9 19 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S275 EP S283 DI 10.1097/CCM.0b013e31817da825 PG 9 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700005 PM 18594253 ER PT J AU Grathwohl, KW Venticinque, SG Blackbourne, LH Jenkins, DH AF Grathwohl, Kurt W. Venticinque, Steven G. Blackbourne, Lorne H. Jenkins, Donald H. TI The evolution of military trauma and critical care medicine: Applications for civilian medical care systems SO CRITICAL CARE MEDICINE LA English DT Editorial Material C1 [Grathwohl, Kurt W.] Univ Texas Hlth Sci Ctr San Antonio, Dept Anesthesia & Operat Serv, Div Anesthesiol & Crit Care Med, San Antonio, TX 78229 USA. [Venticinque, Steven G.] Univ Texas Hlth Sci Ctr San Antonio, Brooke Army Med Ctr, Dept Surg, Trauma Div, San Antonio, TX 78229 USA. [Blackbourne, Lorne H.] Univ Texas Hlth Sci Ctr San Antonio, Dept Anesthesiol & Crit Care Med, San Antonio, TX 78229 USA. [Jenkins, Donald H.] Univ Texas Hlth Sci Ctr San Antonio, Audie L Murphy Mem Vet Adm Hosp, Dept Surg, Trauma Div, San Antonio, TX 78229 USA. [Jenkins, Donald H.] USA, Inst Surg Res, Brooke Army Med Ctr, Trauma Serv, Ft Sam Houston, TX 78234 USA. [Jenkins, Donald H.] Wilford Hall USAF Med Ctr, Dept Surg, Lackland AFB, TX 78236 USA. RP Grathwohl, KW (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Anesthesia & Operat Serv, Div Anesthesiol & Crit Care Med, San Antonio, TX 78229 USA. EM kurtgrathwohl@amedd.army.mil NR 2 TC 6 Z9 6 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S253 EP S254 DI 10.1097/CCM.0b013e31817e325a PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700001 PM 18594249 ER PT J AU Mabry, R McManus, JG AF Mabry, Robert McManus, John G. TI Prehospital advances in the management of severe penetrating trauma SO CRITICAL CARE MEDICINE LA English DT Article DE military; prehospital; penetrating trauma; hemorrhage; tactical ID COMBAT CASUALTY CARE; AORTIC HEMORRHAGE MODEL; 2 ADVANCED DRESSINGS; SPECIAL OPERATIONS; PAIN MANAGEMENT; TRIAGE RULE; LIFESAVING INTERVENTIONS; FLUID RESUSCITATION; DEACETYLATED CHITIN; HEMOSTATIC EFFICACY AB Background: Historic advances in combat prehospital care have been made in the last decade. Unlike other areas of critical care, most of these innovations are not the result of significant improvements in technology, but by conceptual changes in how care is delivered in a tactical setting. The new concept of Tactical Combat Casualty Care has revolutionized the management of combat casualties in the prehospital tactical setting. Discussion: The Tactical Combat Casualty Care concept recognizes the unique epidemiologic and tactical considerations of combat care and that simply extrapolating civilian care concepts to the battlefield are insufficient. Summary: This article examines the most recent and salient advances that have occurred in battlefield prehospital care driven by our ongoing combat experience in the Iraq and Afghanistan and the evolution around the Tactical Combat Casualty Care concept. C1 [Mabry, Robert; McManus, John G.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. RP Mabry, R (reprint author), Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. EM robert.mabry@amedd.army.mil NR 81 TC 26 Z9 26 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S258 EP S266 DI 10.1097/CCM.0b013e31817da674 PG 9 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700003 PM 18594251 ER PT J AU Malchow, RJ Black, IH AF Malchow, Randall J. Black, Ian H. TI The evolution of pain management in the critically ill trauma patient: Emerging concepts from the global war on terrorism SO CRITICAL CARE MEDICINE LA English DT Review DE acute pain management; multimodal analgesia; regional analgesia; regional anesthesia; critical care analgesia ID INTENSIVE-CARE-UNIT; POSTOPERATIVE EPIDURAL ANALGESIA; POSTTRAUMATIC-STRESS-DISORDER; CEREBRAL BLOOD-FLOW; REGIONAL ANESTHESIA; CYCLOOXYGENASE-2 INHIBITORS; MEDICARE PATIENTS; PLEXUS BLOCK; DOUBLE-BLIND; MECHANICAL VENTILATION AB Background., The evolution of military medical care to manage polytrauma, critically ill-wounded warriors from the greater war on terrorism has been accompanied by significant changes in the diagnosis, management, and modulation of acute and chronic trauma-related pain. A paradigm shift in pain management includes early treatment of pain at the point of injury and throughout the continuum of care with a combination of standard and novel therapeutic interventions. These concepts are important for all critical care providers because they translate to most critically ill patients, including those resulting from natural disasters. Previous authors have reported a high incidence of moderate to severe pain and poor analgesia in intensive care units associated with sleep disturbances, tachycardia, pulmonary complications, increased stress response with thromboembolic incidents, and immunosuppression, increased intensive care unit and hospital stays, and needless suffering. Although opioids have traditionally been the cornerstone of acute pain management, they have potential negative effects ranging from sedation, confusion, respiratory depression, nausea, ileus, constipation, tolerance, opioid-induced hyperalgesia as well as potential for immunosuppression. Alternatively, multimodal therapy is increasingly recognized as a critical pain management approach, especially when combined with early nutrition and ambulation, designed to improve functional recovery and decrease chronic pain conditions. Discussion: Multimodal therapy encompasses a wide range of procedures and medications, including regional analgesia with continuous epidural or peripheral nerve block infusions, judicious opioids, acetaminophen, anti-inflammatory agents, anticonvulsants, ketamine, clonidine, mexiletine, antidepressants, and anxiolytics as options to treat or modulate pain at various sites of action. Summary: With a more aggressive acute pain management strategy, the military has decreased acute and chronic pain conditions, which may have application in the civilian sector as well. C1 [Malchow, Randall J.; Black, Ian H.] Brooke Army Med Ctr, Dept Anesthesiol, San Antonio, TX USA. RP Malchow, RJ (reprint author), Brooke Army Med Ctr, Dept Anesthesiol, San Antonio, TX USA. EM randallmalchow@earthlink.net NR 166 TC 41 Z9 42 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 EI 1530-0293 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S346 EP S357 DI 10.1097/CCM.0b013e31817e2fc9 PG 12 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700014 PM 18594262 ER PT J AU Murray, CK AF Murray, Clinton K. TI Infectious disease complications of combat-related injuries SO CRITICAL CARE MEDICINE LA English DT Article DE combat; injury; war; infection; bacteria; history; Iraq; Afghanistan ID VENTILATOR-ASSOCIATED PNEUMONIA; OPERATION ENDURING FREEDOM; KOREAN BATTLE CASUALTY; US ARMY SOLDIERS; WAR WOUNDS; ACINETOBACTER-BAUMANNII; ANAEROBIC INFECTIONS; MILITARY PERSONNEL; BACTERIAL FLORA; UNITED-STATES AB Background. Strategies currently used to prevent morbidity and mortality associated with combat-related injuries include better training of frontline medical personnel, improved personal protective equipment, and deployment of fast-forward surgical assets with state-of-the-art equipment. These strategies allow patients to survive near-catastrophic injuries, placing a greater emphasis on the medical infrastructure to mitigate short- and long-term complications associated with these injuries. Discussion: Wounds have certain characteristics that promote the development of infections: the presence of devitalized tissue, foreign bodies, clots, fluid collections, and contamination of wounds with bacteria from the casualty's skin, the environment, and the hospital. All of these factors culminate in placing the casualty at risk of developing an infection. Summary: This article reviews the lessons learned from combat-related wound infections throughout history and in the current conflicts in Iraq and Afghanistan. Many of the management strategies used to prevent infections of combat-related injuries are applicable to the management of civilian trauma, whether associated with small arms fire or related to natural disasters such as earthquakes or tornadoes. C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil NR 97 TC 30 Z9 31 U1 3 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S358 EP S364 DI 10.1097/CCM.0b013e31817e2ffc PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700015 PM 18594263 ER PT J AU Perkins, JG Cap, AP Weiss, BM Reid, TJ Bolan, CE AF Perkins, Jeremy G. Cap, Andrew P. Weiss, Brendan M. Reid, Thomas J. Bolan, Charles E. TI Massive transfusion and nonsurgical hemostatic agents SO CRITICAL CARE MEDICINE LA English DT Review DE massive transfusion; trauma; coagulopathy; hemostasis; blood components ID RECOMBINANT-FACTOR-VIIA; ACTIVATED FACTOR-VII; DISSEMINATED INTRAVASCULAR COAGULATION; FRESH-FROZEN PLASMA; RED-BLOOD-CELLS; V LIVER-INJURIES; ADJUNCTIVE HEMORRHAGE CONTROL; LIFE-THREATENING HEMORRHAGE; MULTIPLE ORGAN FAILURE; VITRO THROMBELASTOGRAPHY MEASUREMENTS AB Background. Hemorrhage in trauma is a significant challenge, accounting for 30% to 40% of all fatalities, second only to central nervous system injury as a cause of death. However, hemorrhagic death is the leading preventable cause of mortality in combat casualties and typically occurs within 6 to 24 hrs of injury. In cases of severe hemorrhage, massive transfusion may be required to replace more than the entire blood volume. Early prediction of massive transfusion requirements, using clinical and laboratory parameters, combined with aggressive management of hemorrhage by surgical and nonsurgical means, has significant potential to reduce early mortality. Discussion. Although the classification of massive transfusion varies, the most frequently used definition is ten or more units of blood in 24 hrs. Transfusion of red blood cells is intended to restore blood volume, tissue perfusion, and oxygen-carrying capacity; platelets, plasma, and cryoprecipitate are intended to facilitate hemostasis through prevention or treatment of coagulopathy. Massive transfusion is uncommon in civilian trauma, occurring in only 1% to 3% of trauma admissions. As a result of a higher proportion of penetrating injury in combat casualties, it has occurred in approximately 8% of Operation Iraqi Freedom admissions and in as many as 16% during the Vietnam conflict. Despite its potential to reduce early mortality, massive transfusion is not without risk. It requires extensive blood-banking resources and is associated with high mortality. Summary. This review describes the clinical problems associated with massive transfusion and surveys the nonsurgical management of hemorrhage, including transfusion of blood products, use of hemostatic bandages/agents, and treatment with hemostatic medications. C1 [Perkins, Jeremy G.; Cap, Andrew P.; Weiss, Brendan M.; Reid, Thomas J.] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. [Bolan, Charles E.] NHLBI, NIH, Hematol Branch, Bethesda, MD 20892 USA. RP Perkins, JG (reprint author), Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. EM jeremy.perkins1@us.army.mil NR 389 TC 50 Z9 55 U1 1 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S325 EP S339 DI 10.1097/CCM.0b013e31817e2ec5 PG 15 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700012 PM 18594260 ER PT J AU Ritenour, AE Baskin, TW AF Ritenour, Amber E. Baskin, Toney W. TI Primary blast injury: Update on diagnosis and treatment SO CRITICAL CARE MEDICINE LA English DT Article DE primary blast injury; explosion; treatment; diagnosis ID ANESTHETIZED RAT; EXPLOSIVE BLAST; MANAGEMENT; SURVIVORS; SYSTEM; OVERPRESSURE; PATHOLOGY; GUIDE; EAR AB Background: Injuries from combat and terrorist explosions are increasing worldwide. As such, physicians can expect to treat more patients with complex and unique patterns of injury produced not only by fragments and blunt trauma, but also by high-pressure air expanding from the detonation center. Discussion: Tissue damage from the blast wave or primary blast injury can be an important cause of occult trauma to the ocular, aural, pulmonary, cardiovascular, musculoskeletal, and neurologic systems. Awareness of the extensive corporal effects of the blast wave is an essential prerequisite to diagnosis. Summary: This article focuses on the incidence, risk factors, diagnosis, management, and screening for primary blast injury. C1 [Ritenour, Amber E.; Baskin, Toney W.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Baskin, TW (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM toney.baskin@amedd.army.mil NR 47 TC 59 Z9 63 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S311 EP S317 DI 10.1097/CCM.0b013e31817e2a8c PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700010 PM 18594258 ER PT J AU Smith, KK AF Smith, Kimberly K. TI Critical care nursing in an austere environment SO CRITICAL CARE MEDICINE LA English DT Article DE austere; critical care nursing; battlefield; casualty; competency; en route care; combat casualty care ID TRAUMA; WAR AB Objective. The purpose of this article is to present an overview of critical care nursing in current battlefield healthcare environments. The various levels of tactical combat casualty care are described with emphasis on those levels in which military critical care nurses are practicing. Results. Results of a critical care medical record review is presented to describe mechanism of injury, critical care diagnoses, length of stay, ventilator days, procedures, and complications. Conclusion: A vast knowledge of various critical care and trauma processes as well as a wide variety of nursing skills are required to provide appropriate care for these casualties. Critical care nursing competencies, cognitive and skill-focused, required to practice in this environment are described. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Smith, KK (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM kimberly.k.smith@amedd.army.mil NR 4 TC 14 Z9 14 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S297 EP S303 DI 10.1097/CCM.0b013e31817daa01 PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700008 PM 18594256 ER PT J AU Spinella, PC AF Spinella, Philip C. TI Warm fresh whole blood transfusion for severe hemorrhage: US military and potential civilian applications SO CRITICAL CARE MEDICINE LA English DT Article DE whole blood; trauma; mortality; hemorrhage; coagulopathy; combat ID DONOR LEUKOCYTE MICROCHIMERISM; ACUTE TRAUMATIC COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; COMBAT-RELATED CASUALTIES; 753 CONSECUTIVE DEATHS; ACTIVATED FACTOR-VII; MASSIVE TRANSFUSION; CELL TRANSFUSIONS; CRITICALLY-ILL; INDEPENDENT PREDICTOR AB Objective. The objective of this study was to review the history and current literature regarding the benefits and risks of warm fresh whole blood transfusion to include recent U.S. Army research from Afghanistan and Iraq. We also discuss current indications for its use as well as potential civilian applications for large-scale disasters. Background. The use of warm fresh whole blood currently only persists in emergency life-threatening scenarios when tested stored blood components are not available. Recent combat operations in Afghanistan and Iraq have redirected attention on the benefits and risks of warm fresh whole blood for life-threatening injuries in casualties. Main Results: Between March 2003 and July 2007, over 6000 units of warm fresh whole blood have been transfused in Afghanistan and Iraq by U.S. medical providers to patients with life-threatening traumatic injuries with hemorrhage. Preliminary results in approximately 500 patients with massive transfusion indicate that the amount of fresh warm whole blood transfused is independently associated with improved 48-hr and 30-day survival and the amount of stored red blood cells is independently associated with decreased 48-hr and 30-day survival for patients with traumatic injuries that require massive transfusion. Risks of warm fresh whole blood transfusion include the transmission of infectious agents and the potential for microchimerism. Conclusions: For patients with life-threatening hemorrhage at risk for massive transfusion, if complete component therapy is not available or not adequately correcting coagulopathy, the risk: benefit ratio of warm fresh whole blood transfusion favors its use. In addition, recent evidence suggests that there is potential for warm fresh whole blood to be more efficacious than stored component therapy that includes stored red blood cells in critically ill patients requiring massive transfusion. Efforts must continue to improve the safety of warm fresh whole blood transfusion for patients when it is required in emergency situations. U.S. civilian disaster agencies are preparing guidelines for its use in massive casualty scenarios and prospective, randomized trials are about to start to determine whether stored warm fresh (<24 hrs) whole blood improves outcomes compared with standard stored component therapy. C1 [Spinella, Philip C.] Connecticut Childrens Med Ctr, Hartford, CT USA. [Spinella, Philip C.] USA, Inst Surg Res, San Antonio, TX USA. RP Spinella, PC (reprint author), Connecticut Childrens Med Ctr, Hartford, CT USA. EM pspinella@ccmckids.org NR 64 TC 91 Z9 101 U1 3 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S340 EP S345 DI 10.1097/CCM.0b013e31817e2ef9 PG 6 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700013 PM 18594261 ER PT J AU Venticinque, SG Grathwohl, KW AF Venticinque, Steven G. Grathwohl, Kurt W. TI Critical care in the austere environment: Providing exceptional care in unusual places SO CRITICAL CARE MEDICINE LA English DT Article DE critical care; intensive care; austere; remote; disaster; field oxygen ID MECHANICAL VENTILATION; INTENSIVE-CARE; BEDSIDE ULTRASONOGRAPHY; IRAQ; CASUALTIES; MANAGEMENT; SUPPORT; IMPACT; WAR; ICU AB Background. War and other disasters are inexorably linked to illness and injury. As a consequence of this, healthcare providers will be challenged to provide advanced physiological support to preserve human life. Given the mobility and modularity of modern medical systems, the ability to provide critical care outside of the confines of traditional hospitals under such circumstances has become not only a reality and periodic necessity, but an expectation. Austerity amplifies the complexity of providing high-level critical care, because resources are frequently limited, providers are asked to fill unexpected roles determined by necessity, security may be threatened, and the population at risk and their afflictions can be highly diverse. Discussion: Our current deployed military medical experience and a review of published literature pertaining to civilian medical disaster response efforts support these stated challenges. The fundamentals of successful critical care practice in unusual settings include proper planning with an emphasis on attention to detail, the careful management of all resources, using the proper equipment, leveraging aeromedical evacuation assets, and employing the right people with the right skills. Summary: Adherence to sound, evidence-based, routine practice, within bounds of the circumstances, must underscore everything. C1 [Venticinque, Steven G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Anesthesiol, San Antonio, TX 78229 USA. [Grathwohl, Kurt W.] Brooke Army Med Ctr, Dept Anesthesiol, Ft Sam Houston, TX 78234 USA. RP Venticinque, SG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Anesthesiol, San Antonio, TX 78229 USA. EM steven.venticinque@va.gov NR 54 TC 19 Z9 20 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S284 EP S292 DI 10.1097/CCM.0b013e31817da8ec PG 9 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700006 PM 18594254 ER PT J AU White, CE Renz, EM AF White, Christopher E. Renz, Evan M. TI Advances in surgical care: Management of severe burn injury SO CRITICAL CARE MEDICINE LA English DT Article DE burns; burn wounds; burn units; trauma; fluid therapy; resuscitation; humans; life support care; respiratory support; evacuation; military medicine; military personnel; Iraq; Afghanistan; United States; war ID OPERATION IRAQI FREEDOM; ACUTE KIDNEY INJURY; MILITARY CASUALTIES; ENDURING FREEDOM; RENAL-FAILURE; RHABDOMYOLYSIS; RESUSCITATION; TRANSPORT AB Background. Management of combat casualties with severe burns and associated traumatic injuries requires a coordinated interaction of surgical, critical care, and evacuation assets. These patients present enormous challenges to the entire medical system as a result of the severity of injury combined with the great distance required for transport to definitive care. Objective. The objective of this study was to review and highlight some of the advances in burn critical care experienced during recent combat operations. This review focuses on initial resuscitation, respiratory support, care of the burn wound, and long range evacuation. Data Source: The authors conducted a search of the MEDLINE database and manual review of published articles and abstracts from national and international meetings in addition to Institute of Surgical Research Burn Center registry. Conclusions. Fluid resuscitation during the first 24 to 48 hrs after injury remains a significant challenge for all who manage burn casualties. Guidelines have been developed in an effort to standardize fluid resuscitation during this time. These guidelines along with the standardization of burn wound care and continued provider education have resulted in decreased morbidity and mortality in severely burned patients returning from war zones. This system of care for severely burned patients facilitates the transfer of the burn casualty between healthcare providers and facilities and is now being integrated into the catchment area for the Institute of Surgical Research Burn Center. C1 [White, Christopher E.; Renz, Evan M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP White, CE (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM christopher.white@amedd.army.mil NR 18 TC 29 Z9 31 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUL PY 2008 VL 36 IS 7 SU S BP S318 EP S324 DI 10.1097/CCM.0b013e31817e2d64 PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 324AU UT WOS:000257490700011 PM 18594259 ER PT J AU Trattler, WB Barnes, SD AF Trattler, William B. Barnes, Scott D. TI Current trends in advanced surface ablation SO CURRENT OPINION IN OPHTHALMOLOGY LA English DT Article DE advanced techniques; LASIK; PRK; surface ablation ID IN-SITU KERATOMILEUSIS; ONSET CORNEAL HAZE; PHOTOREFRACTIVE KERATECTOMY; MITOMYCIN-C; EXCIMER-LASER; FORME-FRUSTE; PAIN-CONTROL; HIGH MYOPIA; OUTCOMES; PROPHYLAXIS AB Purpose of review Since their introduction in the mid-1990s, surface ablation techniques have continued to evolve, enabling surgeons to give patients better quality of vision with less postoperative pain. The purpose of this chapter is to discuss that evolution, the common techniques used today, and how to address potential complications. Recent findings Advanced surface ablation techniques offer advantages over laser in situ keratomileusis, including expanded potential patient profiles, reduced haze and pain postoperatively, and increased quality of vision. Haze reduction via preserved epithelial flaps, smoother stromal beds, and introduction of mitomycin-C intraoperatively have all improved safety outcomes of advanced surface ablation. Summary Experience has shown us that virtually all patients who are candidates for laser in situ keratomileusis can be candidates for surface ablation, but patients with specific ocular conditions, such as epithelial basement membrane dystrophy, superficial corneal scars, and previous radial keratotomy will have the best outcomes with surface ablation. Surface ablation and laser in situ keratomileusis are comparable in terms of safety and quality of vision. Wavefront-guided photorefractive keratectomy offers better acuity and less induction of higher order aberrations than wavefront-guided laser in situ keratomileusis. C1 [Trattler, William B.] Ctr Excellence Eye Care, Miami, FL 33176 USA. [Barnes, Scott D.] Womack Army Med Ctr, Dept Ophthalmol, Ft Bragg, NC USA. RP Trattler, WB (reprint author), Ctr Excellence Eye Care, Baptist Med Arts Bldg,8940 N Kendall Dr,Suite 400, Miami, FL 33176 USA. EM wtrattler@gmail.com NR 47 TC 25 Z9 29 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-8738 J9 CURR OPIN OPHTHALMOL JI Curr. Opin. Ophthalmol. PD JUL PY 2008 VL 19 IS 4 BP 330 EP 334 DI 10.1097/ICU.0b013e3283034210 PG 5 WC Ophthalmology SC Ophthalmology GA 320LR UT WOS:000257236500010 PM 18545017 ER PT J AU Carter, R AF Carter, Robert, III TI Exertional Heat Illness and Hyponatremia: An Epidemiological Prospective SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review AB CARTER, R. Exertional heat illness and hyponatremia: an epidemiological prospective. Curr. Sports Med. Rep., Vol. 7, No. 4, pp. S20YS27, 2008. In active populations, heat illness remains a cause of exercise-related injury and death. There is evidence that hyponatremia also occurs, but less often than heat illness. Incidence rates of these conditions are determined by the population at risk and individual susceptibilities. Improved strategies are needed to identify high-risk individuals who are likely to develop either hyponatremia or heat illness. C1 [Carter, Robert, III] Ctr Rech Serv Sante Armees, Dept Human Factors, La Tronche, France. [Carter, Robert, III] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Carter, R (reprint author), Ctr Rech Serv Sante Armees, Dept Human Factors, La Tronche, France. EM robert.carteriii@us.army.mil NR 49 TC 11 Z9 11 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD JUL-AUG PY 2008 VL 7 IS 4 SU 1 BP S20 EP S27 DI 10.1249/JSR.0b013e31817f38ff PG 8 WC Sport Sciences SC Sport Sciences GA V15HD UT WOS:000207792200005 ER PT J AU Montain, SJ AF Montain, Scott J. TI Strategies to Prevent Hyponatremia During Prolonged Exercise SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review AB MONTAIN, S. J. Strategies to prevent hyponatremia during prolonged exercise. Curr. Sports Med. Rep., Vol. 7, No. 4, pp. S28-S35, 2008. The causative factors of exercise-associated hyponatremia are critically examined and preventive strategies provided. The existing data support the hypothesis that the pathogenesis is predictable based upon water, sodium, and potassium balance. Preventive strategies are to avoid overdrinking relative to sweating rate and to consider electrolyte replacement when sustained sweating is expected to produce large deficits. C1 USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01746 USA. RP Montain, SJ (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Bldg 42,Kansas St, Natick, MA 01746 USA. EM scott.montain@us.army.mil NR 54 TC 2 Z9 2 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD JUL-AUG PY 2008 VL 7 IS 4 SU 1 BP S28 EP S35 DI 10.1249/JSR.0b013e31817f3a64 PG 8 WC Sport Sciences SC Sport Sciences GA V15HD UT WOS:000207792200006 ER PT J AU Subbaiah, MV Kalyani, S Reddy, GS Boddu, VM Krishnaiah, A AF Subbaiah, M. Venkata Kalyani, S. Reddy, G. Sankara Boddu, Veera M. Krishnaiah, A. TI Biosorption of Cr(VI) from Aqueous Solutions Using Trametes Versicolor Polyporus Fungi SO E-JOURNAL OF CHEMISTRY LA English DT Article DE Biosorption; Chromium; Polyporus fungi; Isotherm models ID HEAVY-METAL BIOSORPTION; ASPERGILLUS-NIGER; MODIFIED BIOMASS; BIOSORBENT; REMOVAL; MECHANISMS; LEAD(II); SORPTION AB Removal of chromium(VI) from aqueous solution was studied using abundantly available trametes versicolor polyponts fungi as biosorbing medium under equilibrium and column flow conditions. Various sorption parameters such as contact time, effect of pH, concentration of Cr(VI) and amount of biomass on the adsorption capacity of the biosorbent were studied. The equilibrium adsorption data were fitted to Freundlich and Langmuir adsorption isotherm models and the model parameters are evaluated. In addition, the data were used to predict the kinetics of adsorption. The results indicated that the adsorption of Cr(VI) on fungi followed second order kinetics. The column flow adsorption data were used to predict break through curves. The fungi loaded with Cr(VI) was regenerated with 0.1 M NaOH solution and the regenerated biomass was used in the subsequent adsorption-desorption cycles. The experimental results demonstrated that the trametes versicolor polyporus fungi could be used as sorbent for immobilizing Cr(VI). C1 [Subbaiah, M. Venkata; Kalyani, S.; Reddy, G. Sankara; Krishnaiah, A.] Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Lab, Tirupati 517502, Andhra Pradesh, India. [Boddu, Veera M.] USA, Engineer & Res Ctr, Environm Proc Branch, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Subbaiah, MV (reprint author), Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Lab, Tirupati 517502, Andhra Pradesh, India. EM abburikrishnaiah@gmail.com RI swayampakula, kalyani/D-6233-2011; Dr. Munagapati, Venkata Subbaiah/D-6761-2011 NR 32 TC 4 Z9 4 U1 0 U2 3 PU WWW PUBL PTE PI TAMIL NADU PA KHADAR BLDG, NEAR SHIFA HOSP, ADIRAMPATTINAM, TAMIL NADU, 614 701, INDIA SN 0973-4945 J9 E-J CHEM JI E-J. Chem. PD JUL-SEP PY 2008 VL 5 IS 3 BP 499 EP 510 PG 12 WC Chemistry, Multidisciplinary SC Chemistry GA 460RD UT WOS:000267203900012 ER PT J AU Schneider, S Hawkins, T Rosander, M Vaghjiani, G Chambreau, S Drake, G AF Schneider, Stefan Hawkins, Tommy Rosander, Michael Vaghjiani, Ghanshyam Chambreau, Steven Drake, Gregory TI Ionic liquids as hypergolic fuels SO ENERGY & FUELS LA English DT Article ID SALTS; DICYANAMIDE C1 [Schneider, Stefan; Hawkins, Tommy; Rosander, Michael; Vaghjiani, Ghanshyam; Chambreau, Steven] USAF, Res Lab, Edwards AFB, CA 93524 USA. [Drake, Gregory] USA, Aviat & Missile Res Dev & Engn Ctr, Prop & Struct Directorate, AMSRD AMR PS PT, Redstone Arsenal, AL 35898 USA. RP Schneider, S (reprint author), USAF, Res Lab, 10 E Saturn Blvd,Bldg 8451, Edwards AFB, CA 93524 USA. EM stefan.schneider@edwards.af.mil NR 14 TC 133 Z9 140 U1 4 U2 45 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0887-0624 J9 ENERG FUEL JI Energy Fuels PD JUL-AUG PY 2008 VL 22 IS 4 BP 2871 EP 2872 DI 10.1021/ef800286b PG 2 WC Energy & Fuels; Engineering, Chemical SC Energy & Fuels; Engineering GA 328IX UT WOS:000257793200100 ER PT J AU Pepi, M Wechsler, G AF Pepi, Marc Wechsler, Gary TI Failure analysis of a horizontal hinge pin from an army cargo helicopter SO ENGINEERING FAILURE ANALYSIS LA English DT Article DE failure analysis; horizontal hinge pin; army cargo helicopter; rolling contact fatigue AB A horizontal hinge pin (HHP) assembly from an army cargo helicopter was examined to determine the root cause of ring and roller spalling and fracture. Chemical analyses, metallography and hardness testing indicated that the rings and rollers conformed to the material requirements of the governing drawing. Metallography and visual and scanning electron microscopy indicated the failure likely initiated in the lag ring due to rolling contact fatigue (RCF) because of high service loads. Evidence of subsurface crack initiation was observed. Published by Elsevier Ltd. C1 [Wechsler, Gary] Aviat & Missile Cmd, Huntsville, AL 35898 USA. [Pepi, Marc] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wechsler, G (reprint author), Aviat & Missile Cmd, Huntsville, AL 35898 USA. EM gary.wechsler@amrdec.army.mil NR 7 TC 0 Z9 0 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1350-6307 J9 ENG FAIL ANAL JI Eng. Fail. Anal. PD JUL PY 2008 VL 15 IS 5 BP 597 EP 605 DI 10.1016/j.engfailanal.2007.04.002 PG 9 WC Engineering, Mechanical; Materials Science, Characterization & Testing SC Engineering; Materials Science GA 279SX UT WOS:000254376000017 ER PT J AU Korotkevich, AO Pushkarev, A Resio, D Zakharov, VE AF Korotkevich, A. O. Pushkarev, A. Resio, D. Zakharov, V. E. TI Numerical verification of the weak turbulent model for swell evolution SO EUROPEAN JOURNAL OF MECHANICS B-FLUIDS LA English DT Article DE weak turbulence; wave kinetic equation; Hasselmann equation; numerical simulation ID SURFACE GRAVITY-WAVES; CAPILLARY WAVES; ENERGY-TRANSFER; OCEAN WAVES; WIND STRESS; SEA WAVES; SIMULATION; SPECTRUM; PROBABILITY; STATISTICS AB The purpose of this article is to numerically verify the theory of weak turbulence. We have performed numerical simulations of an ensemble of nonlinearly interacting free gravity waves (a swell) by two different methods: by solving the primordial dynamical equations describing the potential flow of an ideal fluid with a free surface, and by solving the kinetic Hasselmann equation, describing the wave ensemble in the framework of the theory of weak, turbulence. In both cases we have observed effects predicted by this theory: frequency downshift, angular spreading and formation of a Zakharov-Filonenko spectrum I-omega similar to omega(-4). To achieve quantitative coincidence of the results obtained by different methods, we have to augment the Hasselmann kinetic equation by an empirical dissipation term S-diss modeling the coherent effects of white-capping. Using the standard dissipation terms from the operational wave predicting model (WAM) leads to a significant improvement on short times, but does not resolve the discrepancy completely, leaving the question about the optimal choice of Sdiss open. In the long run, WAM dissipative terms essentially overestimate dissipation. (C) 2007 Elsevier Masson SAS. All rights reserved. C1 [Korotkevich, A. O.; Zakharov, V. E.] RAS, LD Landau Theoret Phys Inst, Moscow 119334, Russia. [Pushkarev, A.; Zakharov, V. E.] RAS, PN Lebedev Phys Inst, Moscow 119991, Russia. [Pushkarev, A.; Zakharov, V. E.] Waves & Solitons LLC, Phoenix, AZ 85045 USA. [Resio, D.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Zakharov, V. E.] Univ Arizona, Dept Math, Tucson, AZ 85721 USA. RP Korotkevich, AO (reprint author), RAS, LD Landau Theoret Phys Inst, 2 Kosygin Str, Moscow 119334, Russia. EM kao@itp.ac.ru; andrei@cox.net; zakharov@math.arizona.edu RI Zakharov, Vladimir/F-1461-2016; Zakharov, Vladimir/G-7276-2016; Pushkarev, Andrei/I-8290-2016; OI Pushkarev, Andrei/0000-0001-9310-5888; zakharov, vladimir/0000-0001-8855-7185 NR 58 TC 16 Z9 16 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0997-7546 EI 1873-7390 J9 EUR J MECH B-FLUID JI Eur. J. Mech. B-Fluids PD JUL-AUG PY 2008 VL 27 IS 4 BP 361 EP 387 DI 10.1016/j.euromechflu.2007.08.004 PG 27 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA 320OU UT WOS:000257245200001 ER PT J AU Krieg, SA Henne, MB Westphal, LM AF Krieg, Sacha A. Henne, Melinda B. Westphal, Lynn M. TI Obstetric outcomes in donor oocyte pregnancies compared with advanced maternal age in in vitro fertilization pregnancies SO FERTILITY AND STERILITY LA English DT Article DE donor oocyte; pregnancy complications; neonatal outcomes; assisted reproductive technology ID ASSISTED REPRODUCTIVE TECHNOLOGY; DONATION; WOMEN; IVF AB Objective: To evaluate obstetric complications in women who conceived through donated oocytes compared with women who conceived through assisted reproduction using autologous oocytes. Design: Retrospective cohort analysis. Setting: Stanford Hospital and Clinics and Lucille Packard Children's hospital, both tertiary referral centers. Patient(S): A cohort of 71 oocyte recipients who underwent in vitro fertilization (IVF) were compared to all women over 38 years who conceived through IVF with autologous oocytes (n = 108) between January 1, 2001, and December 31, 2005, at Stanford University and subsequently delivered infants at Lucille Packard Children's Hospital. Intervention(s): Assisted reproductive technology with donor oocytes. Main Outcome Measure(s): Obstetric charts of the donor-oocyte recipients were compared for all women over 38 years old who had conceived through IVF with autologous oocytes at the same center (n = 108) and delivered at the same hospital during the same time period. Perinatal complications including preeclampsia, diabetes, preterm labor, preterm premature rupture of membranes and placental abnormalities, mode of delivery, presentation, Apgar scores, gestational age at delivery, and weight were compared between the groups. Result(s): Oocyte recipients and autologous oocyte controls had similar rates of complications of prematurity, hypertensive disorders of pregnancy, gestational diabetes, and placental abnormalities. Infant birth weights and gestational age at time of delivery were similar between the two groups. Conclusion(S): This study suggests that women undergoing IVF with donor oocytes are not at increased risk for complications during pregnancy or at increased immediate neonatal complications compared with women of advanced maternal age undergoing IVF with autologous oocytes. C1 [Krieg, Sacha A.] Stanford Univ, Sch Med, Dept Obstet & Gynecol, Stanford, CA 94305 USA. [Henne, Melinda B.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Westphal, Lynn M.] Stanford Univ, Sch Med, Div Reprod Endocrinol & Infertil, Stanford, CA 94305 USA. RP Westphal, LM (reprint author), Stanford Univ, Sch Med, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, 900 Welch Rd,Suite 14, Palo Alto, CA 94304 USA. EM skrieg@stanford.edu NR 18 TC 48 Z9 52 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JUL PY 2008 VL 90 IS 1 BP 65 EP 70 DI 10.1016/j.fertnstert.2007.06.014 PG 6 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 326YM UT WOS:000257695600010 PM 17727845 ER PT J AU Cardello, A Lawless, HT Schutz, HG AF Cardello, Armand Lawless, Harry T. Schutz, Howard G. TI Effects of extreme anchors and interior label spacing on labeled affective magnitude scales SO FOOD QUALITY AND PREFERENCE LA English DT Article DE labeled magnitude scale; labeled affective magnitude scale; context effects; range effects; hedonic scaling ID ACROSS-GROUP COMPARISONS; TASTE AB Three experiments were conducted to examine the effect of the choice of words for the high and low extreme verbal labels for labeled affective magnitude scales (LAM). In the first study, anchors included greatest imaginable like (or dislike) for "experiences of any kind" and for "a fruit beverage." Anchoring the scale to "any experience" created a compression effect, restricting the range of the scale that was used. However, both versions of the LAM showed equal discrimination of the acceptance ratings of products in a set of five diverse fruit juice beverages. A second study was conducted to examine the scale positions of various high end anchors, including greatest imaginable like (dislike), greatest imaginable liking for foods, beverages and any experience. Using magnitude estimation, more extreme ratings were found for the liking (or disliking) of "any experience" as opposed to simply "greatest imaginable liking" (or disliking) and less extreme ratings for anchoring to foods and beverages. The resulting scale values were used to compare three versions of the LAM, with different end anchors and spacings of the interior nine-point hedonic scale labels. As in the first experiment, the range of scores decreased when the end anchor term included "experiences of any kind" and also when the spacing of the interior hedonic terms was compressed. However, once again the products were differentiated equally well in acceptance scores by all three versions of the scale. With the product set studied here, there is no apparent advantage to the use of an extreme anchor term referring to "experiences of any kind" and use of such an anchor may compress the range of scale values chosen by consumer panelists. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Cardello, Armand] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA. [Cardello, Armand] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Schutz, Howard G.] Univ Calif Davis, Davis, CA 95616 USA. RP Lawless, HT (reprint author), Cornell Univ, Dept Food Sci, Stocking Hall, Ithaca, NY 14853 USA. EM htll@comell.edu NR 19 TC 14 Z9 14 U1 3 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD JUL PY 2008 VL 19 IS 5 BP 473 EP 480 DI 10.1016/j.foodqual.2008.02.003 PG 8 WC Food Science & Technology SC Food Science & Technology GA 303AZ UT WOS:000256013100004 ER PT J AU Odom, WE AF Odom, William E. TI Rush to the exit SO FOREIGN AFFAIRS LA English DT Editorial Material C1 [Odom, William E.] Yale Univ, New Haven, CT 06520 USA. [Odom, William E.] USA, Washington, DC USA. RP Odom, WE (reprint author), Yale Univ, New Haven, CT 06520 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU COUNC FOREIGN RELAT INC PI NEW YORK PA 58 E 68TH ST, NEW YORK, NY 10021 USA SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD JUL-AUG PY 2008 VL 87 IS 4 BP 155 EP 157 PG 3 WC International Relations SC International Relations GA 308VI UT WOS:000256417800017 ER PT J AU Biswas, A Blum, JD Lammers, A Douglas, T AF Biswas, A. Blum, J. D. Lammers, A. Douglas, T. TI Isotopic evidence for changing sources of Mercury to the Arctic SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 18th Annual V M Goldschmidt Conference CY JUL, 2008 CL Vancouver, CANADA C1 [Biswas, A.; Blum, J. D.; Lammers, A.] Univ Michigan, Dept Geol Sci, Ann Arbor, MI 48109 USA. [Douglas, T.] Cold Reg Res & Engn Lab, Fairbanks, AK USA. EM biswasa@email.arizona.edu NR 6 TC 1 Z9 1 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 EI 1872-9533 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD JUL PY 2008 VL 72 IS 12 SU 1 BP A86 EP A86 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 321JU UT WOS:000257301600179 ER PT J AU Douglas, TA Blum, JD Keller, K Guo, L Cai, Y AF Douglas, T. A. Blum, J. D. Keller, K. Guo, L. Cai, Y. TI Geochemical signatures are driven by seasonal flow regimes in the Chena River near Fairbanks, Alaska SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 18th Annual V M Goldschmidt Conference CY JUL, 2008 CL Vancouver, CANADA C1 [Douglas, T. A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. [Blum, J. D.; Keller, K.] Univ Michigan, Ann Arbor, MI 48109 USA. [Guo, L.; Cai, Y.] Univ So Mississippi, Hattiesburg, MS 39406 USA. EM Thomas.A.Douglas@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 EI 1872-9533 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD JUL PY 2008 VL 72 IS 12 SU 1 BP A225 EP A225 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 321JU UT WOS:000257301600457 ER PT J AU Lyles, MB Fredrickson, HL Bednar, AJ Fannin, HB Griffin, D Sobecki, TM AF Lyles, M. B. Fredrickson, H. L. Bednar, A. J. Fannin, H. B. Griffin, D. Sobecki, T. M. TI Medical geology: Dust exposure and potential health risks in the Middle East SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 18th Annual V M Goldschmidt Conference CY JUL, 2008 CL Vancouver, CANADA C1 [Lyles, M. B.] USN, Bur Med & Surg, Washington, DC 20372 USA. [Fredrickson, H. L.; Bednar, A. J.] US EPA, Cincinnati, OH 45268 USA. [Fannin, H. B.] Murray State Univ, Dept Chem, Murray, KY 42071 USA. [Griffin, D.] US Geol Survey, Tallahassee, FL 32310 USA. [Sobecki, T. M.] USA, Corp Engn, Hanover, NH USA. EM mark.lyles@med.navy.mil; Fredrickson.Herbert@epamail.epa.gov; Anthony.J.Bednar@erdc.usace.army.mil; harry.fannin@murraystate.edu; dgriffin@usgs.gov; Terry.M.Sobecki@erdc.usace.army.mil NR 0 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 EI 1872-9533 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD JUL PY 2008 VL 72 IS 12 SU 1 BP A576 EP A576 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 321JU UT WOS:000257301601415 ER PT J AU Taylor, S Guan, Y Matrajt, G AF Taylor, S. Guan, Y. Matrajt, G. TI Oxygen exchange in olivine SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT 18th Annual V M Goldschmidt Conference CY JUL, 2008 CL Vancouver, CANADA C1 [Taylor, S.] USACRREL, Hanover, NH 03755 USA. [Guan, Y.] CALTECH, Pasadena, CA 91125 USA. [Matrajt, G.] Univ Washington, Dept Astron, Seattle, WA 98105 USA. EM Susan.Taylor@usace.army.mil; yunbin@gps.caltech.edu; matrajt@astro.washington.edu NR 2 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 EI 1872-9533 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD JUL PY 2008 VL 72 IS 12 SU 1 BP A938 EP A938 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 321JU UT WOS:000257301602401 ER PT J AU Gomez, JE Fiz, GM Ebeling, RM Dove, JE AF Gomez, Jesus E. Fiz, George M. Ebeling, Robert M. Dove, Joseph E. TI Sand-to-concrete interface response to complex load paths in a large displacement shear box SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE interface; soil; concrete; direct shear; shear stiffness; interface model; retaining wall; lock wall ID TESTING UNRESTRICTED FRICTION; SOLID-SURFACES; STEEL INTERFACES; BEHAVIOR; APPARATUS; SOIL AB The large displacement shear box (LDSB) allows testing of interfaces as large as 711 by 406 nun (28 by 16 in.) with maximum interface displacements of 305 turn (12 in.). This device has been used to investigate the response of a variety of interfaces, including clay-geomembrane interfaces for which large displacements are important. The most recent application of the LDSB was to study the response of several sand-to-concrete interfaces under complex loading paths. In this application, the relevant characteristics of the LDSB are its geometry, which reduces the significance of end effects, its ability to apply monotonic and cyclic loading, and its ability to apply simultaneous changes in shear and normal stresses so that complex loading paths can be followed. This paper describes the main features of the LDSB, as well as the testing procedures and results of the sand-to-concrete interface tests that were performed. A procedure for normalizing the interface shear test data is also presented. This procedure facilitates comparative evaluations of interface response to different types of loading. The test results formed the basis for development of an extended hyperbolic model for interfaces that has been implemented in finite element analyses of soil-structure interaction problems. C1 [Gomez, Jesus E.] Schnabel Engn Associates Inc, W Chester, PA 19380 USA. [Fiz, George M.; Dove, Joseph E.] Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. [Ebeling, Robert M.] USA, Ctr Res Dev & Engn, Informat Technol Lab, Vicksburg, MS 39180 USA. RP Gomez, JE (reprint author), Schnabel Engn Associates Inc, W Chester, PA 19380 USA. NR 46 TC 3 Z9 6 U1 2 U2 9 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0149-6115 J9 GEOTECH TEST J JI Geotech. Test. J. PD JUL PY 2008 VL 31 IS 4 BP 358 EP 369 PG 12 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 327JG UT WOS:000257724800008 ER PT J AU Sherman, M Mody, AN Martinez, R Rodriguez, C Reddy, R AF Sherman, Matthew Mody, Apurva N. Martinez, Ralph Rodriguez, Christian Reddy, Ranga TI IEEE standards supporting cognitive radio and networks, dynamic spectrum access, ana coexistence SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Cognitive radio techniques are being applied to many different communications systems. They hold promise for increasing utilization of radio frequencies that are underutilized today, allowing for improved commercial data services, and allowing for new emergency and military communications services [1]. For example, these techniques are being considered by the U.S. FCC for communications services in unlicensed VHF and UHF TV bands. Although traditionally these techniques are closely associated with software-defined radios, many standards such as WiFi (IEEE 802.11), Zigbee (IEEE 802.15.4), and WiMAX (IEEE 802.16) already include some degree of CR technology today. Further advances are occurring rapidly. IEEE 802.22 will be the first cognitive radio-based international standard with tangible frequency bands for its operation. Standardization is at the core of the current and future success of cognitive radio. Industry stake-holders are participating in international standards activities governing the use of cognitive radio techniques for dynamic spectrum access and coexistence, next-generation radio and spectrum management, and interoperability in infrastructure-less wireless networks. This article provides a review of standardization activities for cognitive radio technologies and comments on prospects and issues for future standardization. C1 [Reddy, Ranga] US Army RDECOM CERDEC S&TCD SEAMS, Ft Monmouth, NJ USA. EM matthew.sherman@baesystems.com; apurva.mody@baesystems.com; ralph.martinez@baesystems.com; christian.rodriguez@baesystems.com; ranga.reddy@us.army.mil NR 9 TC 77 Z9 83 U1 0 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD JUL PY 2008 VL 46 IS 7 BP 72 EP 79 DI 10.1109/MCOM.2008.4557045 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 330AG UT WOS:000257911100008 ER PT J AU Koh, G AF Koh, Gary TI Extinction behavior of soil at 26.5 to 110 GHz SO IEEE GEOSCIENCE AND REMOTE SENSING LETTERS LA English DT Article DE millimeter wave measurements; radar terrain factors; soil measurements ID MOISTURE AB Soil electromagnetic properties at the microwave frequencies have been extensively documented in the literature. However, similar information at the higher millimeter frequencies is not available. A laboratory experiment was conducted to investigate the extinction behavior of wet and dry soil at millimeter wavelengths (26.5-110 GHz). For dry soil, the extinction coefficient increased from 0.02 to 0.6 cm(-1) as the frequency increased from 26.5 to 110 GHz. The presence of even a small amount of water in the soil (5% by weight) reduced the penetration of millimeter wave signals into soil by a factor of ten. C1 USA, Cold Reg Res & Engn Lab, Engineer Res Dev Ctr, Hanover, NH 03755 USA. RP Koh, G (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM yeohoon.g.koh@erdc.usace.anny.mil NR 9 TC 1 Z9 1 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1545-598X J9 IEEE GEOSCI REMOTE S JI IEEE Geosci. Remote Sens. Lett. PD JUL PY 2008 VL 5 IS 3 BP 346 EP 348 DI 10.1109/LGRS.2008.916073 PG 3 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 333HW UT WOS:000258144600006 ER PT J AU Ooi, BS Djie, HS Wang, Y Tan, CL Hwang, JCM Fang, XM Fastenau, JM Liu, AWK Dang, GT Chang, WH AF Ooi, Boon S. Djie, Hery Susanto Wang, Yang Tan, Chee-Loon Hwang, James C. M. Fang, Xiao-Ming Fastenau, Joel M. Liu, Amy W. K. Dang, Gerard T. Chang, Wayne H. TI Quantum dashes on InP substrate for broadband emitter applications SO IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS LA English DT Article DE broadband semiconductor laser; dash-in-well; InAs/InAlGaAs; InAs/InP; quantum dash (Qdash); quantum dots (QDs); quantum well (QW); supercontinuum; superiuminescent diode (SLD) ID DOT SUPERLUMINESCENT DIODES; SEMICONDUCTOR OPTICAL AMPLIFIERS; WELL LASER; MU-M; PERFORMANCE; OPERATION; EMISSION; 1.3-MU-M AB We report on the development of InAs/InGaAlAs quantum-dash-in-well structure on InP substrate for wideband emitter applications. A spectral width as broad as 58 meV observed from both photoluminescence and surface photovoltage spectroscopy on the sample indicating the formation of highly inhomogeneous InAs-dash structure that results from the quasi-continuous interband transition. The two-section superluminescent diodes (SLDs), with integrated photon absorber slab as lasing suppression section, fabricated on the InAs dash-in-well structure exhibits the close-to-Gaussian emission with a bandwidth (full-width at half-maximum) of up to 140 nm at similar to 1.6 mu m peak wavelength. The SLD produces a low spectrum ripple of 0.3 dB and an integrated power of similar to 2 mW measured at 20 degrees C under 8 kA/cm(2). The oxide stripe laser exhibits wide lasing wavelength coverage of up to 76 nm at similar to 1.64 mu m center wavelength and an output optical power of similar to 400 mW from simultaneous multiple confined states lasing at room temperature. This rule changing broadband lasing signature, different from the conventional interband diode laser, is achieved from the quasi-continuous interband transition formed by the inhomogeneous quantum-dash nanostructure. C1 [Ooi, Boon S.; Djie, Hery Susanto; Wang, Yang; Tan, Chee-Loon; Hwang, James C. M.] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Ooi, Boon S.; Djie, Hery Susanto; Wang, Yang; Tan, Chee-Loon; Hwang, James C. M.] Lehigh Univ, Ctr Opt Technol, Bethlehem, PA 18015 USA. [Fang, Xiao-Ming; Fastenau, Joel M.; Liu, Amy W. K.] IQE Inc, Bethlehem, PA 18015 USA. [Dang, Gerard T.; Chang, Wayne H.] USA, Res Lab, Adelphi, MD 20783 USA. RP Ooi, BS (reprint author), Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. EM bsooi@lehigh.edu; hery@ieee.org; clt206@lehigh.edu; jh00@lehigh.edu; xfang@iqep.com; jfastenau@iqep.com; aliu@iqep.com; gdang@arl.army.ml; wchang@arl.army.mil RI Ooi, Boon/D-4370-2011 OI Ooi, Boon/0000-0001-9606-5578 NR 32 TC 48 Z9 48 U1 3 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1077-260X J9 IEEE J SEL TOP QUANT JI IEEE J. Sel. Top. Quantum Electron. PD JUL-AUG PY 2008 VL 14 IS 4 BP 1230 EP 1238 DI 10.1109/JSTQE.2008.919277 PG 9 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 335IT UT WOS:000258285000032 ER PT J AU Djie, HS Wang, Y Ding, YH Wang, DN Hwang, JCM Fang, XM Wu, Y Fastenau, JM Liu, AWK Dang, GT Chang, WH Ooi, BS AF Djie, Hery Susanto Wang, Yang Ding, Yun-Hsiang Wang, Dong-Ning Hwang, James C. M. Fang, Xiao-Ming Wu, Ying Fastenau, Joel M. Liu, Amy W. K. Dang, Gerard T. Chang, Wayne H. Ooi, Boon S. TI Quantum dash intermixing SO IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS LA English DT Article DE disordering; interdiffusion; ion-implantation; photonic integrated circuits (PICs); quantum-dash (Qdash); quantum-dot intermixing; quantum-well (QW) intermixing ID PHOTONIC INTEGRATED-CIRCUITS; ION-IMPLANTATION; WELL LASER; INTERDIFFUSION; DIFFUSION; PLASMA AB We investigate the intermixing effect in InAs/InAlGaAs quantum-dash-in-well structures grown on InP sunstrate. Both impurity-free vacancy disordering (IFVD) via dielectric cap annealing, and impurity-induced disordering (IID) using nitrogen ion-implantation techniques have been employed to spatially control the group-III intermixing in the quantum-dash (Qdash) system. Differential bandgap shifts of up to 80 nm and 112 nm have been observed from the IFVD and IID processes, respectively. Compared to the control (nonintermixed) lasers, the light-current characteristics for the 125 nm wavelength shifted Qdash lasers are not significantly changed, suggesting that the quality of the intermixed material is well preserved. The intermixed lasers exhibit a narrower linewidth as compared to the as-grown laser due to the improved dash homogeneity. The integrity of the material is retained after intermixing, suggesting the potential application for the planar integration of multiple active/passive Qdash-based devices on a single InP chip. C1 [Djie, Hery Susanto; Wang, Yang; Ding, Yun-Hsiang; Wang, Dong-Ning; Hwang, James C. M.; Ooi, Boon S.] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Wang, Yang; Ding, Yun-Hsiang; Wang, Dong-Ning; Hwang, James C. M.; Ooi, Boon S.] Lehigh Univ, Ctr Opt Technol, Bethlehem, PA 18015 USA. [Fang, Xiao-Ming; Wu, Ying; Fastenau, Joel M.; Liu, Amy W. K.] IQE Inc, Bethlehem, PA 18015 USA. [Dang, Gerard T.; Chang, Wayne H.] USA, Res Lab, Adelphi, MD 20783 USA. RP Djie, HS (reprint author), JDS Uniphase Corp, San Jose, CA 95134 USA. EM hery@ieee.org; yaw2@gmail.com; yud205@Lehigh.EDU; dow2@lehigh.edu; jh00@gmail.com; xfang@iqep.com; ywu@iqep.com; jfastenau@iqep.com; aliu@iqep.com; gdang@arl.army.com; wchang@arl.army.com; bsooi@lehigh.edu RI Ooi, Boon/D-4370-2011 OI Ooi, Boon/0000-0001-9606-5578 NR 31 TC 16 Z9 16 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1077-260X J9 IEEE J SEL TOP QUANT JI IEEE J. Sel. Top. Quantum Electron. PD JUL-AUG PY 2008 VL 14 IS 4 BP 1239 EP 1249 DI 10.1109/JSTQE.2008.921396 PG 11 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 335IT UT WOS:000258285000033 ER PT J AU Moran, ML Greenfield, RJ AF Moran, Mark L. Greenfield, Roy J. TI Estimation of the acoustic-to-seismic coupling ratio using a moving vehicle source SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE acoustic applications; acoustic reflection; atmospheric measurements; surface acoustic wave signal processing ID WAVES; SOUND AB We present a simple passive technique for estimating the acoustic-to-seismic signal coupling ratio (SAR) in the ground using noise produced by moving vehicles. The seismic signal received on a geophone contains some energy that has propagated as seismic waves and some energy that couples from acoustic waves to seismic waves in the vicinity of the geophone. We use the frequency-domain coherence between the microphone and geophone signals to determine when the seismic signal is predominantly due to acoustic-to-seismic wave coupling. In frequency bands where the microphone and geophone coherence is above 0.8, the ratio of the seismic ground particle velocity to sound pressure-SAR-can be determined with less than 2 dB of error. The method is applied to data from a summer experiment with grass ground cover and at two winter experiments with snow-covered ground. At 100 Hz, the summer analysis yields a SAR value of 1.0 x 10(-5) [(m/s)/Pa]. In addition, at 100 Hz, the two winter tests yield SAR between 0.1 x 10(-5) and 1.0 x 10(-5) [(m/s)/Pa]. In the later winter result, our vehicle-derived SAR estimate is shown to be in excellent agreement with SAR estimates obtained from blank pistol shots. Through the opportunistic exploitation background noise sources, our approach opens the possibility for automatic adaptation of unattended acoustic area, monitoring sensors to changing ground conditions. C1 [Moran, Mark L.; Greenfield, Roy J.] USACE ERDC, Hanover, NH 03755 USA. RP Moran, ML (reprint author), USACE ERDC, Hanover, NH 03755 USA. EM mark.l.moran@erdc.usace.army.mil NR 19 TC 2 Z9 3 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD JUL PY 2008 VL 46 IS 7 BP 2038 EP 2043 DI 10.1109/TGRS.2007.910712 PG 6 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 321DP UT WOS:000257285200016 ER PT J AU Raca, D Harke, MC Lorenz, RD AF Raca, Dejan Harke, Michael C. Lorenz, Robert D. TI Robust magnet polarity estimation for initialization of PM synchronous machines with near-zero saliency SO IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS LA English DT Article; Proceedings Paper CT 41st Annual Meeting of the IEEE-Industry-Applications-Society CY OCT 08-12, 2006 CL Tampa, FL SP IEEE Ind Applicat Soc DE initial position estimation; permanent-magnet (PM) machines; self-sensing; sensorless ID ROTOR POSITION ESTIMATION; MOTOR DRIVE; SPEED AB This paper investigates magnet polarity estimation of permanent-magnet synchronous machines. Because the magnet polarity is estimated from low signal-to-noise ratio signals, it is sensitive to additional signal content, affecting the robustness of magnet polarity estimate. An evaluation of eight low-saliency machines identifies a dc-offset vector in the positive second-harmonic carrier signal current as the primary source of magnet polarity estimation error. Angular offset is a secondary limitation to the polarity estimation robustness. By estimating and decoupling the dc-offset vector and the angular offset, the robustness is improved, and applicability to a wide set of the machines is enabled. C1 [Raca, Dejan] Magnetek Inc, Ctr Res & Dev, Menomonee Falls, WI 53051 USA. [Harke, Michael C.] Hamilton Sundstrand, Dept Appl Res, Rock Isl, IL 61125 USA. [Lorenz, Robert D.] Univ Wisconsin, Dept Mech Engn, Madison, WI 53706 USA. [Lorenz, Robert D.] Univ Wisconsin, Dept Elect & Comp Engn, Madison, WI 53706 USA. RP Raca, D (reprint author), Magnetek Inc, Ctr Res & Dev, Menomonee Falls, WI 53051 USA. EM draca@ieee.org; mcharke@ieee.org; r.d.lorenz@ieee.org NR 18 TC 29 Z9 39 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-9994 J9 IEEE T IND APPL JI IEEE Trans. Ind. Appl. PD JUL-AUG PY 2008 VL 44 IS 4 BP 1199 EP 1209 DI 10.1109/TIA.2008.926195 PG 11 WC Engineering, Multidisciplinary; Engineering, Electrical & Electronic SC Engineering GA 334ZH UT WOS:000258260100029 ER PT J AU Anandkumar, A Tong, L Swami, A AF Anandkumar, Animashree Tong, Lang Swami, Ananthram TI Distributed estimation via random access SO IEEE TRANSACTIONS ON INFORMATION THEORY LA English DT Article DE distributed inference; random-access communications; sensor networks ID CHANNELS AB In this correspondence, the problem of distributed Bayesian estimation is considered in the context of a wireless sensor network. The Bayesian estimation performance is analyzed in terms of the expected Fisher information normalized by the transmission rate of the sensors. The sensors use a communication scheme known as the type-based random access (TBRA) scheme. Under a constraint on the expected transmission energy, an optimal spatio-temporal allocation scheme that maximizes the performance metric is characterized. It is shown that the performance metric is crucially dependent on the fading parameter known as the channel coherence index. For channels with low coherence indices, sensor transmissions tend to cancel each other, and there exists an optimal finite mean transmission rate that maximizes the performance metric. On the other hand, for channels with high coherence indices, there should be as many simultaneous transmissions as allowed by the network. The presence of a critical coherence index where the change from one behavior to another occurs is established. C1 [Anandkumar, Animashree; Tong, Lang] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Anandkumar, A (reprint author), Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. EM aa332@cor-nell.edu; ltong@ece.cornell.edu; a.swami@ieee.org NR 13 TC 3 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9448 J9 IEEE T INFORM THEORY JI IEEE Trans. Inf. Theory PD JUL PY 2008 VL 54 IS 7 BP 3175 EP 3181 DI 10.1109/TIT.2008.924652 PG 7 WC Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 318SC UT WOS:000257111500023 ER PT J AU Enaya, H Semenov, YG Kim, KW Zavada, JM AF Enaya, Hani Semenov, Yuriy G. Kim, K. W. Zavada, John M. TI Nonvolatile memory via spin polaron formation SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Article DE magnetic memories; semiconductor memories ID MAGNETIC POLARONS AB A nonvolatile memory is explored theoretically by utilizing the magnetic exchange interaction between localized holes and an adjacent ferromagnetic (FM) material. The active device consists of a buried semiconductor quantum dot (QD) and an FM insulating layer that share an interface. The hole population in the QD is controlled by particle transfer with a reservoir of itinerant holes over a permeable barrier. A theoretical model based on the free energy calculation demonstrates the existence of a bistable state through the mechanism of a collective spin polaron, whose formation and dissolution can be manipulated electrically via a gate bias pulse. The parameter space window suitable for bistability is examined along with the conditions that support maximum nonvolatility. The limitation of QD size scaling is analyzed in terms of the bit retention time. C1 [Enaya, Hani; Semenov, Yuriy G.; Kim, K. W.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Zavada, John M.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Enaya, H (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM haenaya@ncsu.edu; ygsemeno@ncsu.edu; kwk@ncsu.edu; jmzavada@ncsu.edu FU U.S. Army Research Office; Federal Rules of Civil Procedure (FCRP); Center on Functional Engineered Nano Architectonics (FENA) FX This work was supported in part by the U.S. Army Research Office and in part by the Federal Rules of Civil Procedure (FCRP) Center on Functional Engineered Nano Architectonics (FENA). The review of this paper was arranged by Associate Editor D. Litvinov. NR 9 TC 3 Z9 3 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD JUL PY 2008 VL 7 IS 4 BP 480 EP 483 DI 10.1109/TNANO.2008.926332 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA 342EB UT WOS:000258766300015 ER PT J AU Blum, RS Sadler, BM AF Blum, Rick S. Sadler, Brian M. TI Energy efficient signal detection in sensor networks using ordered transmissions SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE censoring; cross-layer design; energy efficiency; sensor networking; sequential detection; signal detection AB Signal detection is one application for which dedicated sensor networks have been proposed. Joint signal processing and communication design of such networks has been of great interest recently. We consider new approaches where transmissions can be ordered and halted when sufficient evidence is accumulated. We demonstrate that these approaches require, on average, fewer sensor transmissions and that the savings can. be significant in cases of interest. We describe a highly efficient approach which saves transmissions over either the optimum unconstrained energy approach or censoring while achieving the same err-or probability as these approaches. The average number of transmissions saved (ANTS) is lower bounded by a quantity proportional to the number of sensors employed provided a well-behaved distance measure between the sensor distributions is sufficiently large. For such cases, the ANTS over the optimum unconstrained energy approach is shown to be larger than half the number of sensors employed. Numerical results for a mean-shift hypothesis testing problem with Gaussian noise show significant savings even for smaller values of the distance measure. C1 [Blum, Rick S.] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Blum, RS (reprint author), Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA. EM rblum@eecs.lehigh.edu; bsadler@art.army.mil NR 16 TC 58 Z9 59 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD JUL PY 2008 VL 56 IS 7 BP 3229 EP 3235 DI 10.1109/TSP.2008.919101 PN 2 PG 7 WC Engineering, Electrical & Electronic SC Engineering GA 319WO UT WOS:000257195900016 ER PT J AU Zapor, MJ Erwin, D Erowele, G Wortmann, G AF Zapor, Michael J. Erwin, Daniel Erowele, Goldina Wortmann, Glenn TI Emergence of multidrug resistance in bacteria and impact on antibiotic expenditure at a major army medical center caring for soldiers wounded in Iraq and Afghanistan SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID US MILITARY; CASUALTIES; INFECTION AB Since the invasions of Iraq and Afghanistan, the epidemiologic traits of clinical isolates at Walter Reed Army Medical Center have shifted toward drug-resistant strains of microorganisms, particularly among the gram-negative bacteria. Moreover, antibiotic prescribing patterns during this period have changed remarkably and mirror the emergence of these organisms at our institution. C1 [Zapor, Michael J.; Wortmann, Glenn] Walter Reed Army Med Ctr, Dept Med, Infect Dis Serv, Washington, DC 20307 USA. [Erwin, Daniel] Walter Reed Army Med Ctr, Dept Pathol, Infect Dis Serv, Washington, DC 20307 USA. [Erowele, Goldina] Walter Reed Army Med Ctr, Dept Pharm, Infect Dis Serv, Washington, DC 20307 USA. RP Zapor, MJ (reprint author), Walter Reed Army Med Ctr, Dept Med, Infect Dis Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM Michael.Zapor@amedd.army.mil NR 10 TC 10 Z9 10 U1 1 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JUL PY 2008 VL 29 IS 7 BP 661 EP 663 DI 10.1086/588702 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 323NF UT WOS:000257452100013 PM 18593337 ER PT J AU Griffith, ME Gonzalez, RS Holcomb, JB Hospenthal, DR Wortmann, GW Murray, CK AF Griffith, Matthew E. Gonzalez, Russell S. Holcomb, John B. Hospenthal, Duane R. Wortmann, Glenn W. Murray, Clinton K. TI Factors associated with recovery of Acinetobacter baumannii in a combat support hospital SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID RISK-FACTORS; IRAQ; SOLDIERS; OUTBREAK AB A retrospective review of hospital records for Acinetobacter baumannii infection at a US Army combat support hospital revealed a monthly infection rate ranging from 20.5 to 0 cases per 1,000 patients admitted. The rate correlated with the mean census of host-nation patients in the intensive care unit, the mean census of host-nation patients on the wards, and length of stay in the intensive care unit. C1 [Hospenthal, Duane R.; Murray, Clinton K.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Griffith, Matthew E.; Gonzalez, Russell S.] 86th Combat Support Hosp, Baghdad, Iraq. [Wortmann, Glenn W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil NR 9 TC 21 Z9 22 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JUL PY 2008 VL 29 IS 7 BP 664 EP 666 DI 10.1086/589585 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 323NF UT WOS:000257452100014 PM 18547156 ER PT J AU Baum, BS Schnall, BL Tis, JE Lipton, JS AF Baum, Brian S. Schnall, Barri L. Tis, John E. Lipton, Jill S. TI Correlation of residual limb length and gait parameters in amputees SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE transfemoral; above-knee; amputation; amputee; limb length; gait; resection ID TRANSFEMORAL AMPUTEES; PROSTHETIC FEET; HIP MUSCLES; AMPUTATION; WALKING AB There is a lack of objective data on acceptable transection Levels for transfemoral amputation. We retrospectively correlated the residual limb length of 13 young, athletic transfemoral and knee disarticulation amputees with temporal-spatial, kinematic, and kinetic outcomes after gait analysis. It was hypothesised that shorter residual limb lengths would correlate with greater gait deviations. Patients' residual femoral lengths ranged from 57% to 100% of their intact femoral length. With the exception of one patient, pelvic tilt excursion was inversely related to residual limb Length. Limb length did not significantly correlate with any other temporal-spatial, kinematic, or kinetic parameter investigated. Consequently, these results suggest that if the femur is at least 57% of the length of the contralateral femur, length does not dramatically alter gait. This implies that surgeons may have more flexibility to amputate at a higher level to preserve soft tissue quality and improve prosthetic fitting without sacrificing gait function. Published by Elsevier Ltd. C1 [Baum, Brian S.] Walter Reed Army Med Ctr, Ctr Performance & Clin Res, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Baum, Brian S.; Lipton, Jill S.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. RP Baum, BS (reprint author), Walter Reed Army Med Ctr, Ctr Performance & Clin Res, Dept Orthopaed & Rehabil, Bldg 2A,Room 146,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM Brian.Baum@amedd.army.mil RI Baum, Brian/K-2737-2012 OI Baum, Brian/0000-0003-0692-1962 NR 16 TC 17 Z9 20 U1 1 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD JUL PY 2008 VL 39 IS 7 BP 728 EP 733 DI 10.1016/j.injury.2007.11.021 PG 6 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 329AH UT WOS:000257838800005 PM 18541239 ER PT J AU Buchheit, AA Hilmas, GE FahrenholtZ, WG Deason, DM Wang, H AF Buchheit, Andrew A. Hilmas, Greg E. FahrenholtZ, William G. Deason, Douglas M. Wang, Hsin TI Processing and thermal properties of an Mo5Si3C-SiC ceramic SO INTERMETALLICS LA English DT Article DE molybdenum silicides; thermal properties; reaction synthesis; diffraction; electron microscopy, scanning ID SILICON-CARBIDE COMPOSITES; MECHANICAL-PROPERTIES; SIC-MO-LESS-THAN-OR-EQUAL-TO-5SI3C-LESS-THAN-OR-EQUAL-TO-1 COMPOSITES; PHASE; MOLYBDENUM; STRENGTH AB Composite ceramics containing similar to 25 vol% of the Mo-Si-C ternary compound and SiC (referred to as MS) were reaction hot pressed up to 96% relative density. The electrical resistivity of the composite processed at 2150 degrees C decreased from similar to 4.60 Omega cm at room temperature to 4.15 Omega cm at 700 degrees C. Thermal conductivity of the MS ceramics processed at 2150 degrees C was above 100 W/m K at room temperature, decreasing to between 62 and 68W/mK at 500 degrees C. Using the Eucken model for thermal conductivity, the interconnected SiC phase in the MS materials was calculated to have a room temperature thermal conductivity between 160 and 170 W/rn K. As compared to a baseline SiC composition, the continuous SiC in the MS materials had an average increase in thermal conductivity of similar to 50% over the temperature range of room temperature to 500 degrees C. This increase in thermal conductivity was attributed to the accommodation of impurities that would typically be present in SiC grains and grain boundaries (e.g., N and O) into the ternary phase. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Hilmas, Greg E.; FahrenholtZ, William G.] Univ Missouri, Dept Mat Sci & Engn, Rolla, MO 65409 USA. [Buchheit, Andrew A.] Coorstek Inc, Golden, CO 80401 USA. [Deason, Douglas M.] USA, Space & Missile Def Command, Redstone Arsenal, AL 35898 USA. [Wang, Hsin] Oak Ridge Natl Lab, High Temp Mat Lab, Oak Ridge, TN 37831 USA. RP Hilmas, GE (reprint author), Univ Missouri, Dept Mat Sci & Engn, 225 McNutt Hall, Rolla, MO 65409 USA. EM abuchheit@coorstek.com; ghilmas@mst.edu RI Wang, Hsin/A-1942-2013; OI Wang, Hsin/0000-0003-2426-9867; Fahrenholtz, William/0000-0002-8497-0092 NR 21 TC 2 Z9 2 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0966-9795 J9 INTERMETALLICS JI Intermetallics PD JUL PY 2008 VL 16 IS 7 BP 854 EP 859 DI 10.1016/j.intermet.2008.03.010 PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 325UK UT WOS:000257613600002 ER PT J AU Sloop, JC Lechner, B Washington, G Bumgardner, CL Loehle, WD Creasy, W AF Sloop, Joseph C. Lechner, Brent Washington, Gary Bumgardner, Carl L. Loehle, W. David Creasy, William TI Pyrazole formation: Examination of kinetics, substituent effects, and mechanistic pathways SO INTERNATIONAL JOURNAL OF CHEMICAL KINETICS LA English DT Article ID TRIFLUOROMETHYL-BETA-DIKETONES; DERIVATIVES; REGIOSELECTIVITY; IDENTIFICATION; HETEROCYCLES; CYCLIZATION; INHIBITORS; HYDRAZINES; CATALYSIS; C-13 AB Reaction kinetics for the condensation of 1,3-diketones 1a-0 with selected arylhydrazines (aryl = Ph, 4-NO2Ph, 4-CH3OPh, and 2,4diNO(2)Ph) was studied using F-19 NMR spectroscopy. Product regioselectivity is modulated by reactant ratios, substituents, and acidity. Reaction rates were found to be influenced by substituents on the diketones and on phenylhydrazines as well as by acidity of the reaction medium with rates varying as much as 1000-fold. Hammett rho values for these cyclizations were determined. The reaction was found to be first order in both the diketone and arylhydrazine. The rate-determining step for pyrazole formation shifts as a function of pH. Mechanistic details and reaction pathways supporting these findings are proposed. (C) 2008 Wiley Periodicals, Inc. C1 [Sloop, Joseph C.; Lechner, Brent; Washington, Gary; Loehle, W. David] US Mil Acad, Dept Chem, West Point, NY 10996 USA. [Bumgardner, Carl L.] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA. [Creasy, William] SAIC, Aberdeen Proving Ground, MD 21010 USA. RP Sloop, JC (reprint author), US Mil Acad, Dept Chem, West Point, NY 10996 USA. EM joseph.sloop@usma.edu OI Sloop, Joseph/0000-0001-7639-0234 NR 29 TC 7 Z9 7 U1 0 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0538-8066 J9 INT J CHEM KINET JI Int. J. Chem. Kinet. PD JUL PY 2008 VL 40 IS 7 BP 370 EP 383 DI 10.1002/kin.20316 PG 14 WC Chemistry, Physical SC Chemistry GA 312RV UT WOS:000256689400002 ER PT J AU Veras, JF Carmo, LS Tong, LC Shupp, JW Cummings, C dos Santos, DA Cerqueira, MMOP Cantini, A Nicoli, JR Jett, M AF Veras, Jamaira Fereira do Carmo, Luiz Simeao Tong, Lawrence C. Shupp, Jeffrey W. Cummings, Christiano dos Santos, Deise Aparecida Oliveira Pinho Cerqueira, Monica Maria Cantini, Alvaro Nicoli, Jacques Robert Jett, Marti TI A study of the enterotoxigenicity of coagulase-negative and coagutase-positive staphylococcal isolates from food poisoning outbreaks in Minas Gerais, Brazil SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Article DE staphylococcal enterotoxin; food poisoning; PCR; coagutase-negative ID SHOCK-SYNDROME TOXIN-1; POLYMERASE-CHAIN-REACTION; MULTIPLEX-PCR; EXFOLIATIVE TOXINS; AUREUS; GENES; STRAINS; PREVALENCE; MASTITIS; TSST-1 AB Objectives: The purpose of this study was to identify enterotoxin genes from isolates of coagulase-negative staphylococci and coagutase-positive staphytococci obtained from dairy products, responsible for 16 outbreaks of food poisoning. Methods: From the pool of 152 staphytococcal isolates, 15 coagulase-negative and 15 coagulase-positive representatives were selected for this study. The 15 coagulase-negative isolates were tested for the presence of coo and femA genes, which are known to be characteristic of Staphylococcus aureus. After testing for enterotoxin genes by polymerase chain reaction (PCR), the 30 selected isolates were tested for the presence of toxin by immunoassay. Results: Seven of the coagulase-negative isolates amplified the coo gene and were subsequently reclassified as coagulase-positive. Twenty-one of 30 selected isolates had staphylococcal enterotoxin genes and most of these produced toxin as well. The most frequently encountered enterotoxin genes were sea and seb. Among eight coagulase-negative isolates, five had enterotoxin genes, all of which were found to have detectable toxin by immunoassay. Conclusions: The results from this study demonstrate that coagulase-negative as welt as coagutase-positive staphylococci isolated from dairy products are capable of genotypic and phenotypic enterotoxigenicity. Furthermore, these data demonstrate that PCR is a sensitive and specific method for screening outbreak isolates regardless of coagutase expression. (c) 2007 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. C1 [Veras, Jamaira Fereira; Oliveira Pinho Cerqueira, Monica Maria] Univ Fed Minas Gerais, Escola Vet, Belo Horizonte, MG, Brazil. [do Carmo, Luiz Simeao; dos Santos, Deise Aparecida] FUNED, Lab Enterotoxinas, Belo Horizonte, MG, Brazil. [Tong, Lawrence C.; Shupp, Jeffrey W.; Cummings, Christiano; Jett, Marti] Walter Reed Army Inst Res, Div Pathol, Dept Mol Pathol, Silver Spring, MD 20910 USA. [Cantini, Alvaro; Nicoli, Jacques Robert] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Belo Horizonte, MG, Brazil. RP Carmo, LS (reprint author), Univ Fed Minas Gerais, Escola Vet, Belo Horizonte, MG, Brazil. EM carmols@pop.com.br RI NUNES, ALVARO/A-4788-2008; Nicoli, Jacques/K-4807-2015; NUNES, ALVARO/F-1703-2017 OI NUNES, ALVARO/0000-0001-8844-8333; NUNES, ALVARO/0000-0001-8844-8333 NR 27 TC 47 Z9 50 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD JUL PY 2008 VL 12 IS 4 BP 410 EP 415 DI 10.1016/j.ijid.2007.09.018 PG 6 WC Infectious Diseases SC Infectious Diseases GA 323HT UT WOS:000257437900013 PM 18206412 ER PT J AU Jemionek, JF Copley, CL Smith, ML Past, MR AF Jemionek, John F. Copley, Curtis L. Smith, Michael L. Past, Marilyn R. TI Concentration distribution of the marijuana metabolite Delta(9)-tetrahydrocannabinol-9-carboxylic acid and the cocaine metabolite benzoylecgonine in the department of defense urine drug-testing program SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID DETECTION TIMES; ORAL INGESTION; EXCRETION; HUMANS C1 [Jemionek, John F.; Smith, Michael L.; Past, Marilyn R.] Armed Forces Inst Pathol, Armed Forces Med Examiner Syst, Div Forens Toxicol, Rockville, MD 20850 USA. [Copley, Curtis L.] USA, dNovus RDI, Med Informat Technol Ctr, San Antonio, TX 78234 USA. RP Jemionek, JF (reprint author), Armed Forces Inst Pathol, Armed Forces Med Examiner Syst, Div Forens Toxicol, Rockville, MD 20850 USA. EM jemionek@afip.osd.mil NR 12 TC 5 Z9 6 U1 0 U2 0 PU PRESTON PUBL INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD JUL-AUG PY 2008 VL 32 IS 6 BP 408 EP 416 PG 9 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 330QY UT WOS:000257959100003 PM 18652746 ER PT J AU Carrera, M Zandomeni, RO Sagripanti, JL AF Carrera, M. Zandomeni, R. O. Sagripanti, J. -L. TI Wet and dry density of Bacillus anthracis and other Bacillus species SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE aerosols; anthrax; biodefense; microbial density; spores ID BACTERIAL-SPORES; WATER-CONTENT; GRADIENT CENTRIFUGATION; HEAT-RESISTANCE; ULTRASTRUCTURE; SEDIMENTATION; SPORULATION; EXOSPORIUM; SEPARATION; DIVERSITY AB Aims: To determine the wet and dry density of spores of Bacillus anthracis and compare these values with the densities of other Bacillus species grown and sporulated under similar conditions. Methods and Results: We prepared and studied spores from several Bacillus species, including four virulent and three attenuated strains of B. anthracis, two Bacillus species commonly used to simulate B. anthracis (Bacillus atrophaeus and Bacillus subtilis) and four close neighbours (Bacillus cereus, Bacillus megaterium, Bacillus thuringiensis and Bacillus stearothermophilus), using identical media, protocols and instruments. We determined the wet densities of all spores by measuring their buoyant density in gradients of Percoll and their dry density in gradients of two organic solvents, one of high and the other of low chemical density. The wet density of different strains of B. anthracis fell into two different groups. One group comprised strains of B. anthracis producing spores with densities between 1.162 and 1.165 g ml(-1) and the other group included strains whose spores showed higher density values between 1.174 and 1.186 g ml(-1). Both Bacillus atrophaeus and B. subtilis were denser than all the B. anthracis spores studied. Interestingly and in spite of the significant differences in wet density, the dry densities of all spore species and strains were similar. In addition, we correlated the spore density with spore volume derived from measurements made by electron microscopy analysis. There was a strong correlation (R(2) = 0.95) between density and volume for the spores of all strains and species studied. Conclusions: The data presented here indicate that the two commonly used simulants of B. anthracis, B. atrophaeus and B. subtilis were considerably denser and smaller than all B. anthracis spores studied and hence, these simulants could behave aerodynamically different than B. anthracis. Bacillus thuringiensis had spore density and volume within the range observed for the various strains of B. anthracis. The clear correlation between wet density and volume of the B. anthracis spores suggest that mass differences among spore strains may be because of different amounts of water contained within wet dormant spores. Significance and Impact of the Study: Spores of nonvirulent Bacillus species are often used as simulants in the development and testing of countermeasures for biodefense against B. anthracis. The similarities and difference in density and volume that we found should assist in the selection of simulants that better resemble properties of B. anthracis and, thus more accurately represent the performance of countermeasures against this threat agent where spore density, size, volume, mass or related properties are relevant. C1 [Sagripanti, J. -L.] USA, RDECOM, AMSRD ECB RT, Edgewood Chem Biol Ctr,Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. [Zandomeni, R. O.] Consejo Nacl Invest Cient & Tecn, Inst Tecnol Agr, RA-1033 Buenos Aires, DF, Argentina. RP Sagripanti, JL (reprint author), USA, RDECOM, AMSRD ECB RT, Edgewood Chem Biol Ctr,Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. NR 31 TC 33 Z9 33 U1 0 U2 13 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1364-5072 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD JUL PY 2008 VL 105 IS 1 BP 68 EP 77 DI 10.1111/j.1365-2672.2008.03758.x PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 309XX UT WOS:000256494600008 PM 18298528 ER PT J AU Alemany, JA Nindl, BC Kellogg, MD Tharion, WJ Young, AJ Montain, SJ AF Alemany, Joseph A. Nindl, Bradley C. Kellogg, Mark D. Tharion, William J. Young, Andrew J. Montain, Scott J. TI Effects of dietary protein content on IGF-I, testosterone, and body composition during 8 days of severe energy deficit and arduous physical activity SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE soldier; caloric deprivation; sleep restriction; underfeeding; body composition ID GROWTH-FACTOR-I; YOUNG MEN; SLEEP-DEPRIVATION; SOMATOMEDIN-C; HEALTHY-MEN; INSULIN; PERFORMANCE; EXERCISE; HORMONE; STRESS AB Energy restriction coupled with high energy expenditure from arduous work is associated with an altered insulin-like growth factor-I (IGF-I) system and androgens that are coincident with losses of fat-free mass. The aim of this study was to determine the effects of two levels of dietary protein content and its effects on IGF-I, androgens, and losses of fat-free mass accompanying energy deficit. We hypothesized that higher dietary protein content would attenuate the decline of anabolic hormones and, thus, prevent losses of fat-free mass. Thirty-four men [24 (SD 0.3) yr, 180.1 (SD 1.1) cm, and 83.0 (SD 1.4) kg] participated in an 8-day military exercise characterized by high energy expenditure (16.5 MJ/ day), low energy intake (6.5 MJ/ day), and sleep deprivation (4 h/24 h) and were randomly divided into two dietary groups: 0.9 and 0.5 g/kg dietary protein intake. IGF-I system analytes, androgens, and body composition were assessed before and on days 4 and 8 of the intervention. Total, free, and nonternary IGF-I and testosterone declined 50%, 64%, 55%, and 45%, respectively, with similar reductions in both groups. There was, however, a diet x time interaction on day 8 for total IGF-I and sex hormone-binding globulin. Decreases in body mass (3.2 kg), fat-free mass (1.2 kg), fat mass (2.0 kg), and percent body fat (1.5%) were similar in both groups (P = 0.01). Dietary protein content of 0.5 and 0.9 g/kg minimally attenuated the decline of IGF-I, the androgenic system, and fat-free mass during 8 days of negative energy balance associated with high energy expenditure and low energy intake. C1 [Alemany, Joseph A.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Kellogg, Mark D.; Tharion, William J.; Young, Andrew J.; Montain, Scott J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. EM bradley.nindl@us.army.mil OI Kellogg, Mark/0000-0003-1868-2153 NR 36 TC 29 Z9 29 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 2008 VL 105 IS 1 BP 58 EP 64 DI 10.1152/japplphysiol.00005.2008 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 327RJ UT WOS:000257745900011 PM 18450989 ER PT J AU Mcfarland, DG Shafer, DJ AF Mcfarland, Dwilette G. Shafer, D. J. TI Factors Influencing Reproduction in American Wild Celery: A Synthesis SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Review DE ecology; Hydrocharitaceac; propagules; restoration; seeds; submersed aquatic vegetation; Vallisneria americana; winter buds ID UPPER MISSISSIPPI-RIVER; SUBMERSED MACROPHYTE GROWTH; POTAMOGETON-PECTINATUS L; FRESH-WATER MACROPHYTES; TIDAL POTOMAC RIVER; VALLISNERIA-AMERICANA; AQUATIC MACROPHYTES; LOW PH; CALOOSAHATCHEE ESTUARY; HYDRILLA-VERTICILLATA AB Dramatic declines in American wild celery (Vallisneria americana Michaux), a native submersed aquatic plant, have been widely reported in the United States since the 1960s, especially from the Midwest to the Northeast. Though methods for restoration are being developed and implemented, progress has been hampered by the need for greater understanding of the species' biological traits and response to environmental change. Here, we review available literature on reproductive ecology of wild celery, focusing on environmental influences on the production and early stages of growth of different propagule types. A background profile of the species describes its ecological importance, field characteristics, taxonomy, life history, and geographical distribution. Critical gaps in present knowledge indicate much has yet to be learned to identify different ecotypes of wild celery based on phenological and genetic distinctions. Further research is also needed to assess potential establishment from seed for consideration as an alternative to (or supplement to) vegetative propagules in restoration strategies. C1 [Mcfarland, Dwilette G.; Shafer, D. J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Mcfarland, DG (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. FU Submerged Aquatic Vegetation Restoration Research Program FX The authors gratefully acknowledge M. Steve Ailstock, Chetta Owens, Angela Poovey, and Dian Smith for their valuable comments and suggestions in a prior review of this manuscript. Ruthie McCoy and Paul Taccarino assisted in obtaining needed reference materials. Funding support was provided by the Submerged Aquatic Vegetation Restoration Research Program. Permission to publish this information was granted by the Chief of Engineers. NR 147 TC 5 Z9 5 U1 1 U2 8 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2008 VL 46 BP 129 EP 144 PG 16 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 364CU UT WOS:000260314600001 ER PT J AU Madsen, JD Wersal, RM Getsinger, KD Nelson, LS AF Madsen, John D. Wersal, R. M. Getsinger, K. D. Nelson, L. S. TI Sensitivity of Wild Rice (Zizania palustris L.) to the Aquatic Herbicide Triclopyr SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE Eurasian watermilfoil management; flowering; growth stage; Renovate (R) 3; tiller; seed head; selectivity ID EURASIAN WATERMILFOIL; TRIFLOXYSULFURON; DISSIPATION; GLYPHOSATE; EFFICACY AB A primary goal of managing invasive aquatic plants is to selectively control the target plant without impacting more desirable plant species. A native plant of concern is wild rice (Zizania palustris L.). Wild rice provides habitat for fish and wildlife, is a food source for waterfowl, and is utilized by humans as a cereal grain. The objective of this study was to examine the sensitivity of three wild rice growth stages, seedling, young, and mature, to aqueous concentrations (0, 0.75, 1.5, and 2.5 mg ae L(-1)) of triclopyr. Plant control was rated on a 0 to 100% scale each week after treatment. At four weeks post treatment, plants were harvested, measured for height (cm), number of seedheads and tillers, and dried at 70 C to a constant mass. Wild rice exposed to the highest concentration of herbicide exhibited reduced height and mass regardless of life stage. The lowest triclopyr concentration did not significantly reduce height, biomass, seedhead density, or tiller formation. Wild rice seedlings exhibited the greatest sensitivity to triclopyr. Young and mature plants were less sensitive than seedling plants to triclopyr applications of 1.5 mg ae L(-1). A triclopyr concentration of 0.75 mg ae L-1 should have a negligible effect on all wild rice growth stages. C1 [Madsen, John D.; Wersal, R. M.] Mississippi State Univ, GeoResources Inst, Mississippi State, MS 39762 USA. [Getsinger, K. D.; Nelson, L. S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Madsen, JD (reprint author), Mississippi State Univ, GeoResources Inst, Mississippi State, MS 39762 USA. EM jmadsen@gri.msstate.edu FU Aquatic Ecosystem Restoration Foundation; US Army Corps of Engineers Aquatic Plant Control Research Program; SePRO Corporation FX This research was supported by the Aquatic Ecosystem Restoration Foundation with additional support by the US Army Corps of Engineers Aquatic Plant Control Research Program and by the SePRO Corporation. We thank Wilfredo Robles, Joshua Cheshier, Jimmy Peeples, Matt Gower, and Steven Gruchy for assistance with planting and harvesting. We thank Chip Welling, Jeremy Slade, and Victor Maddox for reviews of an earlier manuscript. Permission was granted by the Chief of Engineers to publish this information. Approved for publication as Journal Article No.J-11261. of the Mississippi Agricultural and Forestry Experiment Station, Mississippi State University Citation of trade names does not constitute endorsement or approval of the use of such commercial products. NR 27 TC 0 Z9 0 U1 1 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2008 VL 46 BP 150 EP 154 PG 5 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 364CU UT WOS:000260314600003 ER PT J AU Glomski, LM Netherland, MD AF Glomski, Leeann M. Netherland, Michael D. TI Efficacy of Fluridone, Penoxsulam, and Bispyribac-sodium on Variable-leaf Milfoil SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID EURASIAN WATERMILFOIL; ALS-INHIBITORS; HYDRILLA; WATER; LAKE C1 [Glomski, Leeann M.] USA, Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. [Netherland, Michael D.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Glomski, LM (reprint author), USA, Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM LeeAnn.M.Glomski@usace.army.mil NR 22 TC 5 Z9 7 U1 1 U2 5 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2008 VL 46 BP 193 EP 196 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 364CU UT WOS:000260314600013 ER PT J AU Owens, CS Grodowitz, MJ Smart, RM AF Owens, Chetta S. Grodowitz, M. J. Smart, R. M. TI Impact of Insect Herbivory on the Establishment of Hydrilia verticillata (L.f.) Royle Fragments SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID GROWTH C1 [Owens, Chetta S.; Smart, R. M.] USA, Engineer Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75056 USA. [Grodowitz, M. J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Owens, CS (reprint author), USA, Engineer Lewisville Aquat Ecosyst Res Facil, 201 Jones St, Lewisville, TX 75056 USA. NR 15 TC 4 Z9 4 U1 0 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2008 VL 46 BP 199 EP 201 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 364CU UT WOS:000260314600015 ER PT J AU Shearer, JF AF Shearer, Judy F. TI Is Classical Biocontrol Using Fungi a Viable Option for Submersed Aquatic Plant Management? SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID BIOLOGICAL-CONTROL AGENT; WATER-HYACINTH; MYCOLEPTODISCUS-TERRESTRIS; MELALEUCA-QUINQUENERVIA; EURASIAN WATERMILFOIL; HYDRILLA-VERTICILLATA; EICHHORNIA-CRASSIPES; PUCCINIA-PSIDII; HOST-RANGE; PATHOGENS C1 Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shearer, JF (reprint author), Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Judy.F.Shearer@erdc.usace.army.mil NR 36 TC 3 Z9 3 U1 1 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2008 VL 46 BP 202 EP 205 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 364CU UT WOS:000260314600016 ER PT J AU Teyhen, DS Miller, JM Middag, TR Kane, EJ AF Teyhen, Deydre S. Miller, Joseph M. Middag, Tansy R. Kane, Edward J. TI Rotator cuff fatigue and glenohumeral kinematics in participants without shoulder dysfunction SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE biomechanics; humeral head migration; imaging ID SUBACROMIAL SPACE WIDTH; IMPINGEMENT SYNDROME; RADIOGRAPHIC EVALUATION; PRECISION-MEASUREMENT; SEGMENTAL MOTION; SAGITTAL PLANE; HAND-HELD; DYNAMOMETER; ABDUCTION; ACROMION AB Context: Researchers have established that superior migration of the humeral head increases after fatigue of the rotator cuff muscles. In these studies, the investigators used imaging techniques to assess migration of the humeral head during statically held shoulder positions. Their results may not represent the amount of superior humeral head migration that occurs during dynamic arm elevation. Objective: To investigate the effect of rotator cuff fatigue on humeral head migration during dynamic concentric arm elevation (arm at the side [approximately 0 degrees] to 135 degrees) in healthy individuals and to determine the test-retest reliability of digital fluoroscopic video for assessing glenohumeral migration. Design: Test-retest cohort study. Setting: Research laboratory. Patients or Other Participants: Twenty men (age = 27.7 +/- 3.6 years, mass = 81.5 +/- 11.8 kg) without shoulder disorders participated in this study. Intervention(s): Three digital fluoroscopic videos (2 prefatigue and 1 postfatigue) of arm elevation were collected at 30 Hz. The 2 prefatigue arm elevation trials were used to assess test-retest reliability with the arm at the side and at 45 degrees, 90 degrees, and 135 degrees of elevation. The prefatigue and postfatigue digital fluoroscopic videos were used to assess the effects of rotator cuff fatigue on glenohumeral migration. All measurements were taken in the right shoulder. Main Outcome Measure(s): The dependent measure was glenohumeral migration (in millimeters). We calculated the intraclass correlation coefficient and standard error of the measurement to assess the test-retest reliability. A 2 X 4 repeated-measures analysis of variance was used to assess the effects of fatigue on arm elevation at the 4 shoulder positions. Results: The test-retest reliability ranged from good to excellent (.77 to .92). Superior migration of the humeral head increased postfatigue (P < .001), regardless of angle. Conclusions: Digital fluoroscopic video assessment of shoulder kinematics provides a reliable tool for studying kinematics during arm elevation. Furthermore, superior migration of the humeral head during arm elevation increases with rotator cuff fatigue in individuals without shoulder dysfunction. C1 [Teyhen, Deydre S.] Baylor Univ, USA, Ft Sam Houston, TX USA. [Miller, Joseph M.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Middag, Tansy R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Kane, Edward J.] Univ St Augustine, San Diego, CA USA. RP Teyhen, DS (reprint author), 3151 Scott Rd,Room 1303, Ft Sam Houston, TX 78234 USA. EM Deydre.teyhen@amedd.army.mil NR 43 TC 31 Z9 32 U1 0 U2 5 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 J9 J ATHL TRAINING JI J. Athl. Train. PD JUL-AUG PY 2008 VL 43 IS 4 BP 352 EP 358 DI 10.4085/1062-6050-43.4.352 PG 7 WC Sport Sciences SC Sport Sciences GA 334BZ UT WOS:000258198600004 PM 18668167 ER PT J AU Duerkop, BA Herman, JP Ulrich, RL Churchill, MEA Greenberg, EP AF Duerkop, Breck A. Herman, Jake P. Ulrich, Ricky L. Churchill, Mair E. A. Greenberg, E. Peter TI The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone SO JOURNAL OF BACTERIOLOGY LA English DT Article ID LUXR-LUXI FAMILY; PSEUDOMONAS-AERUGINOSA; VIBRIO-FISCHERI; CELL COMMUNICATION; GENE-EXPRESSION; PHZ OPERON; ACTIVATION; REGULON; IDENTIFICATION; PSEUDOMALLEI AB Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor pairs and two additional signal receptors, all of which contribute to virulence. We show that B. mallei produces N-3-hydroxy-octanoyl HSL (30HC(8)-HSL) but a bmaI3 mutant does not. Recombinant Escherichia coli expressing BmaI3 produces hydroxylated acyl-HSLs, with 30HC(8)-HSL being the most abundant compound. In recombinant E. coli, BmaR3 responds to 30HC(8)-HSL but not to other acyl-HSLs. These data indicate that the signal for BmaR3-BmaI3 quorum sensing is 30HC(8)-HSL. C1 [Duerkop, Breck A.; Greenberg, E. Peter] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA. [Herman, Jake P.; Churchill, Mair E. A.] Univ Colorado Denver, Sch Med, Dept Pharmacol, Program Biomol Struct, Aurora, CO 80045 USA. [Ulrich, Ricky L.] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21704 USA. RP Greenberg, EP (reprint author), Univ Washington, Sch Med, Dept Microbiol, 1959 NE Pacific St,Box 357242, Seattle, WA 98195 USA. EM epgreen@u.washington.edu RI Churchill, Mair/C-5549-2014 OI Churchill, Mair/0000-0003-0862-235X FU NIAID NIH HHS [U54 AI057141, R01-AI48660, R01 AI048660, U54AI057141]; NIGMS NIH HHS [GM069338, T32 GM007270, T32 GM07270, U54 GM069338] NR 30 TC 17 Z9 17 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD JUL PY 2008 VL 190 IS 14 BP 5137 EP 5141 DI 10.1128/JB.00246-08 PG 5 WC Microbiology SC Microbiology GA 325PA UT WOS:000257599600040 PM 18487338 ER PT J AU Fukunaga, M Horovitz, SG de Zwart, JA van Gelderen, P Balkin, TJ Braun, AR Duyn, JH AF Fukunaga, Masaki Horovitz, Silvina G. de Zwart, Jacco A. van Gelderen, Peter Balkin, Thomas J. Braun, Allen R. Duyn, Jeff H. TI Metabolic origin of BOLD signal fluctuations in the absence of stimuli SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM LA English DT Article DE BOLD; CMRO2; connectivity; fMRI; resting state; sleep ID CEREBRAL-BLOOD-FLOW; INDEPENDENT COMPONENT ANALYSIS; FUNCTIONAL CONNECTIVITY; OXIDATIVE-METABOLISM; OXYGEN-CONSUMPTION; VISUAL-CORTEX; BASAL GANGLIA; BRAIN; FMRI; OSCILLATIONS AB Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging studies have shown the existence of ongoing blood flow fluctuations in the absence of stimuli. Although this so-called 'resting-state activity' appears to be correlated across brain regions with apparent functional relationship, its origin might be predominantly vascular and not directly representing neuronal signaling. To investigate this, we simultaneously measured BOLD and perfusion signals on healthy human subjects (n = 11) and used their ratio (BOLD/perfusion ratio or BPR) as an indicator of metabolic demand. BPR during rest and sleep was compared with that during a visual task (VT) and a breath-holding task (BH), which are challenges with substantial and little metabolic involvement, respectively. Within the visual cortex, BPR was 3.76 +/- 1.23 during BH, which was significantly higher than during the VT (1.76 +/- 0.27) and rest (1.56 +/- 0.41). Meanwhile, BPR values during VT and rest were not significantly different, suggesting a similar metabolic involvement. Eight subjects showed stage 1 and 2 sleep, during which temporally correlated BOLD and perfusion activity continued. In these subjects, there was no significant difference in BPR between the sleep and waking conditions (1.79 +/- 0.54 and 1.66 +/- 0.67, respectively), but both were lower than the BPR during BH. These data suggest that resting-state activity, at least in part, represents a metabolic process. C1 [Fukunaga, Masaki; Horovitz, Silvina G.; de Zwart, Jacco A.; van Gelderen, Peter; Duyn, Jeff H.] NINDS, Adv MRI, LFMI, Natl Inst Hlth, Bethesda, MD 20892 USA. [Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Braun, Allen R.] NIDCD, Language Sect, Voice Speech & Language Branch, Natl Inst Hlth, Bethesda, MD USA. RP Fukunaga, M (reprint author), NINDS, Adv MRI, LFMI, Natl Inst Hlth, 9000 Rockville Pike,MSC 1065,Bldg 10,Room B1D-72, Bethesda, MD 20892 USA. EM fukunagm@mail.nih.gov RI Duyn, Jozef/F-2483-2010 FU Intramural NIH HHS NR 39 TC 52 Z9 52 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK STREET, 9TH FLOOR, NEW YORK, NY 10013-1917 USA SN 0271-678X J9 J CEREBR BLOOD F MET JI J. Cereb. Blood Flow Metab. PD JUL PY 2008 VL 28 IS 7 BP 1377 EP 1387 DI 10.1038/jcbfm.2008.25 PG 11 WC Endocrinology & Metabolism; Hematology; Neurosciences SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology GA 318DZ UT WOS:000257073100011 PM 18382468 ER PT J AU Bui-Mansfield, LT O'Brien, SD AF Bui-Mansfield, Liem T. O'Brien, Seth D. TI Magnetic Resonance Appearance of Intra-Articular Synovial Sarcoma: Case Reports and Review of the Literature SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE soft tissue sarcoma; synovial sarcoma; musculoskeletal neoplasm; MR imaging; joint ID DIAGNOSIS; TUMORS; KNEE AB Intra-articular synovial sarcoma is extremely rare. The authors report the magnetic resonance appearance of 2 cases of intra-articular synovial sarcoma and review the current medical literature on this subject. Intra-articular synovial sarcoma must be considered in the differential diagnosis of a heterogeneously enhancing multiloculated intra-articular mass, especially in the knee joint, that does not have the typical radiological features of either synovial osteochondromatosis, pigmented villonodular synovitis, or synovial hemangiomas. C1 [Bui-Mansfield, Liem T.; O'Brien, Seth D.] San Antonio Uniformed Serv Hlth Educ Consortium, Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX USA. [Bui-Mansfield, Liem T.] Wake Forest Univ, Dept Radiol, Winston Salem, NC 27109 USA. [Bui-Mansfield, Liem T.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. RP Bui-Mansfield, LT (reprint author), 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM liem.mansfield@gmail.com NR 17 TC 6 Z9 8 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD JUL-AUG PY 2008 VL 32 IS 4 BP 640 EP 644 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 336UL UT WOS:000258390000025 PM 18664855 ER PT J AU Kersten, DD Mines, P Sweet, M AF Kersten, Daniel D. Mines, Pete Sweet, Mark TI Use of the microscope in endodontics: Results of a questionnaire SO JOURNAL OF ENDODONTICS LA English DT Article DE age; endodontics; height; limitations; operating microscope; usage; utilization; web survey ID DENTAL-OPERATING MICROSCOPE; 2ND MESIOBUCCAL CANALS; MAXILLARY MOLARS; SURGERY; MAGNIFICATION; REMOVAL; END AB The purpose of this study was to investigate the frequency and characteristics of operating microscope (OM) utilization among endodontists in the United States. The study also investigated how OM use has changed since a similar study was published nearly a decade ago. A web-based survey regarding OM usage was e-mailed to 2340 active members of the American Association of Endodontists (AAE) in the United States. Data from 1091 questionnaires indicated that 90% of the endodontists surveyed have access to and use the OM in their practice. The frequency of use as a function of years since completing endodontic training was as follows: < 10 years, 95%; 10-15 years, 90%; 16-20 years, 82%; > 21 years, 78%. Previous studies found that shorter operators needed to adopt a strained position to view mandibular molars. Our results indicated with strong correlation (r = 0.90) that shorter endodontists used the microscope more often than taller endodontists, The OM was used most frequently for root-end inspection, locating canal orifices, and root-end filling, respectively. Of the practitioners who used the OM, 59% used it without limitation, 86% used it equally between the maxillary and mandibular arch, and 84% used it as often as anticipated. The most common limitations to OM use were positional difficulty, limited field of view, and inconvenience, respectfully. The use of the OM by endodontists increased from 52% in 1999 to 90% in 2007. C1 [Kersten, Daniel D.; Mines, Pete; Sweet, Mark] USA, Ft Bragg Residency, Ft Bragg, NC USA. RP Kersten, DD (reprint author), Rohde Dent Clin, Bldg 3836,Ardennes Rd, Ft Bragg, NC 28310 USA. EM ddkdds@gmail.com NR 18 TC 11 Z9 14 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUL PY 2008 VL 34 IS 7 BP 804 EP 807 DI 10.1016/j.joen.2008.04.002 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 320JY UT WOS:000257230700004 PM 18570983 ER PT J AU O'Rourke, K Richman, A Roddy, M Custer, M AF O'Rourke, Kathleen Richman, Alice Roddy, Mary Custer, Michael TI Does pregnancy/paternity intention predict contraception use? A study among US soldiers who have completed initial entry training SO JOURNAL OF FAMILY PLANNING AND REPRODUCTIVE HEALTH CARE LA English DT Article DE contraception use; family planning; unintended pregnancy/paternity; US Army ID UNINTENDED PREGNANCY AB Background and methodology The US Army represents a community of young adults at risk for unintended pregnancy/paternity. Our study evaluated the effect of pregnancy/paternity intention on contraceptive choice amongst new, sexually active and non-pregnant recruits. A total of 592 males and 503 females completed self-administered surveys asking about pregnancy/paternity intention, contraceptive use at last intercourse, and potential confounding factors. A multidimensional measurement of pregnancy intention was developed. Contraceptive efficacy was categorised as a four-level ordinal variable. Multivariate ordinal regression measured the association between pregnancy/paternity intention and the most efficacious birth control method used at last intercourse. Results Only 7% of participants planned a pregnancy in the next 6 months, but almost 33% of them used no birth control at last intercourse. Each unit increase in pregnancy avoidance scale was associated with a 14% increase in efficacy of birth control method used (p < 0.0001). Effectiveness of birth control method increased for age (p = 0.0873), post-secondary education (p = 0.0142) and male gender (p = 0.0019.). Binge drinking reduced the likelihood of being in. a higher category of birth control use (p = 0.0258). Discussion and conclusions Intention to avoid pregnancy and being male was associated with use of higher-level birth control methods. C1 [Richman, Alice] Univ S Florida, Dept Community & Family Med, Coll Publ Hlth, Tampa, FL 33612 USA. [O'Rourke, Kathleen; Roddy, Mary] Univ S Florida, Dept Epidemiol & Biostat, Tampa, FL 33612 USA. [Custer, Michael] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. RP Richman, A (reprint author), Univ S Florida, Dept Community & Family Med, Coll Publ Hlth, 13201 Bruce B Downs Blvd,MDC 56, Tampa, FL 33612 USA. EM arichman@health.usf.edu FU PHS HHS [MM 0266 03/03] NR 5 TC 10 Z9 10 U1 0 U2 1 PU PROFESSIONAL, MANAGERIAL & HEALTHCARE PUBLICATIONS LTD PI CHICHESTER PA PO BOX 100, CHICHESTER PO18 8HD, W SUSSEX, ENGLAND SN 1471-1893 J9 J FAM PLAN REPROD H JI J. Fam. Plan. Reprod. Health Care PD JUL PY 2008 VL 34 IS 3 BP 165 EP 168 DI 10.1783/147118908784734891 PG 4 WC Family Studies; Obstetrics & Gynecology; Social Sciences, Biomedical SC Family Studies; Obstetrics & Gynecology; Biomedical Social Sciences GA 318IV UT WOS:000257085700007 PM 18577315 ER PT J AU Rozati, A Tafti, DK Blackwell, NE AF Rozati, Ali Tafti, Danesh K. Blackwell, Neai E. TI Effect of pin tip clearance on flow and heat transfer at low Reynolds numbers SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME LA English DT Article DE heat transfer; pin fins; tip clearance; low Reynolds number; thermal performance; minichannels ID CAST-ALUMINUM COLDWALLS; FIN ARRAYS; PRESSURE-DROP; RIBBED DUCT; PERFORMANCE; EXCHANGERS; CHANNEL; SURFACE AB Cylindrical pin fins with tip clearances are investigated in the low Reynolds number range 5 100, both t* = 0.2D* and 0.3D* were comparable in performance. C1 [Rozati, Ali; Tafti, Danesh K.] Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USA. [Blackwell, Neai E.] USA, RDECOM, CERDEC, Ft Belvoir, VA 22060 USA. RP Tafti, DK (reprint author), Virginia Polytech Inst & State Univ, Dept Mech Engn, 114-L Rendolph Hall,Mail Code 0238, Blacksburg, VA 24061 USA. EM dtafti@vt.edu RI Tafti, Danesh/A-7486-2009 NR 31 TC 5 Z9 6 U1 1 U2 5 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-1481 J9 J HEAT TRANS-T ASME JI J. Heat Transf.-Trans. ASME PD JUL PY 2008 VL 130 IS 7 AR 071704 DI 10.1115/1.2909184 PG 10 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA 321DR UT WOS:000257285400007 ER PT J AU Brown, GL AF Brown, Gary L. TI Approximate profile for nonequilibrium suspended sediment SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article AB The ability to accurately simulate sediment transport processes in natural and engineered systems is crucial to both engineers and scientists. Many researchers have worked on the development of methods that yield reliable predictions of both sediment transport and morphological change with a minimum of computational burden, so that the long prototype time scales necessary to appropriately investigate these processes can be simulated within a reasonable amount of time. This includes the development of tools for approximating the complex behavior of the sediment concentration in the water column. In this technical note, the classic equilibrium sediment profile first introduced by Rouse is revisited. Following the development of the Rouse profile introduced by Einstein, a generalized nonequilibrium sediment concentration profile is generated. The principal assumption is that the convective term of the nonequilibrium vertical sediment flux can be approximated with the relationship that arises from purely convective transport. The method is compared to numerical solutions for depositional profiles, and appears to yield promising results. C1 USA, Corps Engineers, Ctr Res Dev & Engn, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Brown, GL (reprint author), USA, Corps Engineers, Ctr Res Dev & Engn, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 11 TC 3 Z9 5 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUL PY 2008 VL 134 IS 7 BP 1010 EP 1014 DI 10.1061/(ASCE)0733-9429(2008)134:7(1010) PG 5 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA 314UV UT WOS:000256835600015 ER PT J AU Gibson, P AF Gibson, Phil TI Water-repellent Treatment on Military Uniform Fabrics: Physiological and Comfort Implications SO JOURNAL OF INDUSTRIAL TEXTILES LA English DT Article DE repellency; breathable; comfort; nanotechnology; water vapor resistance ID HEAT AB Cost-effective nanotechnology-based water-repellent treatments for clothing fabrics are now commercially available. The effectiveness of these durable water repellent (DWR) fabric treatments are evaluated for application to military uniforms. The addition of a non-wicking finish to clothing fabric negatively impacts comfort in hot and humid environments. Clothing comfort may be improved by refining the DWR fabric treatment process to retain wicking properties on the fabrics inner surface. C1 USA, Natick Soldier Res Dev & Engn Ctr Natick, Natick, MA 01760 USA. RP Gibson, P (reprint author), USA, Natick Soldier Res Dev & Engn Ctr Natick, Natick, MA 01760 USA. EM Phillip.Gibson@us.army.mil RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 NR 12 TC 6 Z9 6 U1 3 U2 14 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1528-0837 J9 J IND TEXT JI J. Ind. Text. PD JUL PY 2008 VL 38 IS 1 BP 43 EP 54 DI 10.1177/1528083707087833 PG 12 WC Materials Science, Textiles SC Materials Science GA 410ZP UT WOS:000263617100002 ER PT J AU Deka, LJ Bartus, SD Vaidya, UK AF Deka, L. J. Bartus, S. D. Vaidya, U. K. TI Damage evolution and energy absorption of E-glass/polypropylene laminates subjected to ballistic impact SO JOURNAL OF MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT Materials Science and Technology Conference and Exhibition (MS&T'07) CY SEP 16-20, 2007 CL Detroit, MI ID HIGH-VELOCITY IMPACT; COMPOSITE STRUCTURES; FIBER-COMPOSITES; PENETRATION; PERFORATION; MODEL; PROJECTILES; PREDICTION; KEVLAR; ARMOR AB High-velocity transverse impact of laminated fiber reinforced composites is of interest in military, marine and structural applications. The overall objective of this work was to investigate the behavior of laminated thermoplastic composites of varying thicknesses under high-velocity impact from an experimental and modeling viewpoint. In order to analyze this problem, a series of ballistic impact tests have been performed on plain weave E-glass/polypropylene (E-glass/PP) composites of different thicknesses using 0.30 and 0.50 caliber right-cylinder shaped projectiles. A gas gun with a sabot stripper mechanism was employed to impact the panels. In order to analyze the perforation mechanisms, ballistic limit and damage evaluation, an explicit three-dimensional finite element code LS-DYNA was used. Material model 162, a progressive failure model based on modified Hashin's criteria, has been assigned to analyze failure of the laminate. The projectile was modeled using Material model 3 (MAT_PLASTIC_KINEMATIC). The laminates and the projectile were meshed using brick elements with single integration points. The impact velocity ranged from 187 to 332 m s(-1). Good agreement between the numerical and experimental results was attained in terms of predicting ballistic limit, delamination and energy absorption of E-glass/PP laminate. C1 [Deka, L. J.; Vaidya, U. K.] Univ Alabama, Dept Mat Sci & Engn, Birmingham, AL 35294 USA. [Bartus, S. D.] Army Res Lab, Aberdeen, MD USA. RP Vaidya, UK (reprint author), Univ Alabama, Dept Mat Sci & Engn, Birmingham, AL 35294 USA. EM uvaidya@uab.edu NR 32 TC 35 Z9 35 U1 2 U2 27 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUL PY 2008 VL 43 IS 13 BP 4399 EP 4410 DI 10.1007/s10853-008-2595-0 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA 304DL UT WOS:000256090100007 ER PT J AU Richards, SL Ghosh, SK Zeichner, BC Apperson, CS AF Richards, Stephanie L. Ghosh, Sujit K. Zeichner, Brian C. Apperson, Charles S. TI Impact of source reduction on the spatial distribution of larvae and pupae of Aedes albopictus (Diptera : Culicidae) in suburban neighborhoods of a Piedmont community in North Carolina SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes albopictus; spatial analysis; geographic information systems; mosquito production; source reduction ID AEGYPTI DIPTERA; UNITED-STATES; EPIDEMIOLOGY; SURVEILLANCE; BEHAVIOR; IQUITOS; PATTERN; VECTOR; SITES; PERU AB Aedes albopictus (Skuse) is a principal nuisance mosquito species and a potential arbovirus vector throughout its geographic range in the United States. This species lays eggs, and progeny complete development in water-filled containers that are disca,rded in suburban landscapes. Source reduction of containers, achieved through environmental sanitation, was used to experimentally manipulate mosquito production to gain insight into the spatial structure of the population of immature Ae. albopictus. Our studies were conducted in suburban landscapes in Raleigh, NC, during the 2002 and 2003 mosquito seasons. Spatial analyses, using estimates of the mean and total standing crop of pupae and counts of the numbers of mosquito-positive containers, showed that the distribution of mosquito production was not spatially dependent on a neighborhood-wide basis. However, in all neighborhoods, mosquito production was clustered in at least one and often more than one adjacent residence. Point pattern analyses that considered only the presence or absence of pupae showed that pupae-positive residences were dispersed throughout neighborhoods receiving monthly source reduction treatments and clustered throughout control neighborhoods, indicating that source reduction affected the spatial distribution of pupae. Conversely, spatial analyses based on the presence or absence of larvae and pupae showed that mosquito production was randomly distributed among residences in both control and source reduction neighborhoods, showing that Ae. albopictus recolonized containers within several weeks after source reduction was implemented. Knowledge of the spatial distribution of production sites would allow management efforts for Ae. albopictus to be targeted to residences supporting high levels of mosquito production. C1 [Richards, Stephanie L.; Apperson, Charles S.] N Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA. [Ghosh, Sujit K.] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA. [Zeichner, Brian C.] USA, Ctr Hlth Promot & Preventat Med, Aberdeen Proving Ground, MD 21010 USA. RP Apperson, CS (reprint author), N Carolina State Univ, Dept Entomol, Campus Box 7647, Raleigh, NC 27695 USA. EM charles_apperson@ncsu.edu OI Ghosh, Sujit/0000-0001-8351-408X FU NIAID NIH HHS [U01-AI-58303-01]; NIEHS NIH HHS [R01 ES014843, R01 ES014843-01A2, R01 ES014843-02] NR 42 TC 24 Z9 26 U1 2 U2 12 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2008 VL 45 IS 4 BP 617 EP 628 DI 10.1603/0022-2585(2008)45[617:IOSROT]2.0.CO;2 PG 12 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 328AB UT WOS:000257768500005 PM 18714860 ER PT J AU Turell, MJ O'Guinn, ML Dohm, D Zyzak, M Watts, D Fernandez, R Calampa, C Klein, TA Jones, JW AF Turell, M. J. O'Guinn, M. L. Dohm, D. Zyzak, M. Watts, D. Fernandez, R. Calampa, C. Klein, T. A. Jones, J. W. TI Susceptibility of Peruvian mosquitoes to eastern equine encephalitis virus SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Peru; eastern equine encephalitis virus; transmission; mosquito ID AMAZON BASIN REGION; VALLEY FEVER VIRUS; ENCEPHALOMYELITIS COMPLEX; VECTOR COMPETENCE; CULEX-PIPIENS; CULICIDAE; DIPTERA; DISSEMINATION; ARBOVIRUS; IQUITOS AB Mosquitoes were collected in the Amazon Basin, near Iquitos, Peru, and used in experimental studies to evaluate their susceptibility to strains of eastern equine encephalitis virus (EEEV) that were isolated from mosquitoes captured within 20 km of Iquitos. When fed on hamsters or chickens with a viremia of approximate to 10(5) plaque-forming units (PFU) of EEEV/ml, Culex pedroi Sirivanakarn and Belkin, Aedes fulvus (Wiedemann), Psorophora albigenu (Peryassu), and Psorophora ferox (Von Humboldt) were susceptible to infection, whereas none of the Aedes serratus (Theobald), Culex vomerifer Komp, Culex gnomatos Sallum, Huchings, and Ferreira, Culex portesi Senevet and Abormenc, or Culex coronator Dyar and Knab became infected, even though they fed on the same viremic blood sources. When these mosquito species fed on animals with viremias of -10' PFU/ml, Cx. pedroi, Ae. fulvus, Ps. albigenu, and Psorophora cingulata (Fabricius) were the most susceptible. Mosquito species were susceptible to both a lineage H (Brazil-Peru) and a lineage III (Argentina-Panama) isolate of EEEV. This study, combined with the repeated isolation of strains of EEEV from Cx. pedroi captured in the Amazon Basin region of Peru, suggests that Cx. pedroi may be the primary enzootic vector of EEEV in this region. C1 [Turell, M. J.; O'Guinn, M. L.; Dohm, D.; Zyzak, M.; Watts, D.; Fernandez, R.; Calampa, C.; Klein, T. A.; Jones, J. W.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.turell@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU NIAID NIH HHS [N01-AI30027] NR 19 TC 10 Z9 10 U1 0 U2 4 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2008 VL 45 IS 4 BP 720 EP 725 DI 10.1603/0022-2585(2008)45[720:SOPMTE]2.0.CO;2 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 328AB UT WOS:000257768500018 PM 18714873 ER PT J AU Ringelberg, D Richmond, M Foley, K Reynolds, C AF Ringelberg, D. Richmond, M. Foley, K. Reynolds, C. TI Utility of lipid biomarkers in support of bioremediation efforts at army sites SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE lipid biomarkers; PLFA; TPH; RDX; contaminated soil ID OIL-CONTAMINATED SOIL; MICROBIAL BIOMASS; COMMUNITY STRUCTURE; BIODEGRADATION; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; DEGRADATION; SUBSURFACE; HYDROCARBONS; EXPLOSIVES; RDX AB Lipid biomarker analysis has proven valuable in testing the hypothesis that attributes of the extant microbiota can directly reflect the occurrence of contaminant biodegradation. Two past research efforts have demonstrated this utility and are described here. A 4.5 m vertical core was obtained from a diesel fuel oil contamination plume. Core material was assayed for total petroleum hydrocarbons (TPH) and bacterial membrane phospholipids (PLFA) via a single solvent extraction. Microbial viable biomass and the relative abundance of Gram-negative bacterial PLFA biomarkers were found to be significantly correlated with TPH concentration. The core TPH profile also revealed two distinct areas where the average TPH level of 3000 mu g g(-1) fell to near detection limits. Both areas were characterized by a three-fold decrease in the hexadecane/pristane ratio, indicating alkane biodegradation, and a distinct PLFA profile that showed a close similarity to the uncontaminated surface soil. Low-order, incomplete detonations can deposit hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) into training range surface soils. Since surface soils are exposed to temporal and diurnal moisture cycles, we investigated the effect two very different soil moisture tensions had on the in situ microbiota and RDX biodegradation. Saturated soils were characterized by rapid RDX biodegradation, 4 day half-life, a decrease in number of species detected and increase in PLFA biomarkers for Gram-negative protcobacteria (n16:1 omega 7c, n18:1 omega 9c, and n18:1 omega 7c) and Gram-positive firmicutes (i 15:0 and a15:0). Terminal restriction fragment length polymorphism (T-RFLP) profiles of endpoint microbial communities indicated a shift from 18 to 36% firmicutes, the loss of gamma-proteobacteria and the emergence of alpha-proteobacteria. These two past research efforts demonstrated the utility of the lipid biomarker analysis in identifying microbial community characteristics that were associated with two very different soil contaminants. Lipid biomarkers defined areas of TPH biodegradation and identified community shifts as a result of soil conditions that affected explosives fate. Information like this can be used to enhance the predictive power of ecological models such as the Army Training and Testing Area Carrying Capacity for munitions model [ATTACC]. Published by Elsevier B.V. C1 [Ringelberg, D.; Richmond, M.; Foley, K.; Reynolds, C.] USA, ERDC CRREL, Hanover, NH 03755 USA. RP Ringelberg, D (reprint author), USA, ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM David.B.Ringelberg@erdc.usace.army.mil NR 33 TC 18 Z9 19 U1 1 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD JUL PY 2008 VL 74 IS 1 BP 17 EP 25 DI 10.1016/j.mimet.2007.07.007 PG 9 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 317RM UT WOS:000257037300004 PM 17714813 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI America, war and power: Defining the state SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2008 VL 72 IS 3 BP 941 EP 941 PG 1 WC History SC History GA 321YX UT WOS:000257343500032 ER PT J AU Palmer, JN AF Palmer, Jason N. Dutch TI The politics of war: Race, class, and conflict in revolutionary Virginia SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Palmer, Jason N. Dutch] US Mil Acad, West Point, NY 10996 USA. RP US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2008 VL 72 IS 3 BP 942 EP 942 PG 1 WC History SC History GA 321YX UT WOS:000257343500033 ER PT J AU Wineman, BA AF Wineman, Bradford A. TI Grant and Lee: Victorious American and vanquished virginian SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Wineman, Bradford A.] USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Wineman, BA (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2008 VL 72 IS 3 BP 962 EP 962 PG 1 WC History SC History GA 321YX UT WOS:000257343500051 ER PT J AU Kiesling, EC AF Kiesling, Eugenia C. TI The embattled self: French soldiers' testimony of the Great War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Kiesling, Eugenia C.] US Mil Acad, West Point, NY 10996 USA. RP Kiesling, EC (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2008 VL 72 IS 3 BP 967 EP 968 PG 2 WC History SC History GA 321YX UT WOS:000257343500056 ER PT J AU Wang, KKW Kobeissy, FH Liu, MC Oli, M Robinson, G Dave, J Tortella, FC Robicsek, SA Gabrielli, A Robertson, C Hayes, RL AF Wang, Kevin K. W. Kobeissy, Firas H. Liu, Ming Cheng Oli, Monika Robinson, Gillian Dave, Jitendra Tortella, Frank C. Robicsek, Steven A. Gabrielli, Andrea Robertson, Claudia Hayes, Ronald L. TI Traumatic brain injury biomarkers: A neuroproteomic-based discovery, systems biology-based selection and validation in animal studies SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 26th Annual National-Neurotrauma-Society Symposium CY JUL 27-30, 2008 CL Orlando, FL SP Natl Neurotrauma Soc C1 [Kobeissy, Firas H.; Robicsek, Steven A.; Gabrielli, Andrea] Univ Florida, Dept Psychiat, Dept Anesthesiol, Gainesville, FL 32611 USA. [Dave, Jitendra; Tortella, Frank C.] Walter Reed Army Inst Res, Div Neurosci, Dept Neuropharmacol & Mol Biol, Silver Spring, MD USA. [Robertson, Claudia] Baylor Coll Med, Dept Neurosurg, Houston, TX 77030 USA. [Wang, Kevin K. W.; Liu, Ming Cheng; Oli, Monika; Robinson, Gillian; Hayes, Ronald L.] Banyan Biomarkers Inc, Alachua, FL USA. RI Dave, Jitendra/A-8940-2011; kobeissy, firas/E-7042-2017 OI kobeissy, firas/0000-0002-5008-6944 NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2008 VL 25 IS 7 MA P93 BP 877 EP 877 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 326BX UT WOS:000257634000103 ER PT J AU Shear, D Chen, ZY Washington, P Evangelista, C Lu, M Tortella, F AF Shear, Deborah Chen, Zhiyong Washington, Patricia Evangelista, Clifford Lu, May Tortella, Frank TI Comparison of the fixed and accelerated speed versions of rotarod testing for the evaluation of motor deficits in an experimental rat model of PBBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 26th Annual National-Neurotrauma-Society Symposium CY JUL 27-30, 2008 CL Orlando, FL SP Natl Neurotrauma Soc C1 [Shear, Deborah; Chen, Zhiyong; Washington, Patricia; Evangelista, Clifford; Lu, May; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2008 VL 25 IS 7 MA P123 BP 884 EP 884 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 326BX UT WOS:000257634000132 ER PT J AU Wei, G Yang, XF Tortella, FC Lu, XCM AF Wei, Guo Yang, Xiaofang Tortella, Frank C. Lu, Xi-Chun M. TI Selective brain cooling attenuates elevated intracranial pressure induced by penetrating ballistic-like brain injury in rats SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 26th Annual National-Neurotrauma-Society Symposium CY JUL 27-30, 2008 CL Orlando, FL SP Natl Neurotrauma Soc C1 [Wei, Guo; Yang, Xiaofang; Tortella, Frank C.; Lu, Xi-Chun M.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2008 VL 25 IS 7 MA P140 BP 888 EP 888 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 326BX UT WOS:000257634000149 ER PT J AU Lu, XCM Si, YZ Cao, Y Hartings, J Wei, G Yang, XF Tortella, F AF Lu, Xi-Chun May Si, Yuanzheng Cao, Ying Hartings, Jed Wei, Guo Yang, Xiaofang Tortella, Frank TI Non-convulsive seizure profiles in rats identified using continuous EEG monitoring following a penetrating ballistic-like brain injury (PBBI) SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 26th Annual National-Neurotrauma-Society Symposium CY JUL 27-30, 2008 CL Orlando, FL SP Natl Neurotrauma Soc C1 [Lu, Xi-Chun May; Si, Yuanzheng; Cao, Ying; Hartings, Jed; Wei, Guo; Yang, Xiaofang; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2008 VL 25 IS 7 MA P182 BP 898 EP 898 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 326BX UT WOS:000257634000190 ER PT J AU Si, YZ Wei, G Chao, Y Lu, XCM Yang, XF Tortella, FC Hartings, JA AF Si, Yuanzheng Wei, Guo Chao, Ying Lu, Xi-Chun May Yang, Xiaofang Tortella, Frank C. Hartings, Jed A. TI EEG changes following penetrating ballistic-like brain injury in rats: A power spectral analysis SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 26th Annual National-Neurotrauma-Society Symposium CY JUL 27-30, 2008 CL Orlando, FL SP Natl Neurotrauma Soc C1 [Si, Yuanzheng; Wei, Guo; Chao, Ying; Lu, Xi-Chun May; Yang, Xiaofang; Tortella, Frank C.; Hartings, Jed A.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2008 VL 25 IS 7 MA P211 BP 906 EP 906 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 326BX UT WOS:000257634000218 ER PT J AU Wei, H Lu, M Phillips, K Yao, CP Tortella, F Dave, J AF Wei, Hans Lu, May Phillips, Katie Yao, Changping Tortella, Frank Dave, Jitendra TI Attenuation of both neuroinflammation and apoptosis with NNZ-2566 treatment in experimental PBBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 26th Annual National-Neurotrauma-Society Symposium CY JUL 27-30, 2008 CL Orlando, FL SP Natl Neurotrauma Soc C1 [Wei, Hans; Lu, May; Phillips, Katie; Yao, Changping; Tortella, Frank; Dave, Jitendra] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2008 VL 25 IS 7 MA P256 BP 917 EP 917 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 326BX UT WOS:000257634000263 ER PT J AU Chen, ZY Evangelista, C Lu, XCM Clarke, D Sing, G Tortella, F AF Chen, Zhiyong Evangelista, Clifford Lu, X. -C. May Clarke, Diana Sing, George Tortella, Frank TI Human amnion-derived multipotent progenitor (AMP) cells seated in a collagen scaffold promote wound recovery: Pre-clinical studies in an experimental model of PBBI SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 26th Annual National-Neurotrauma-Society Symposium CY JUL 27-30, 2008 CL Orlando, FL SP Natl Neurotrauma Soc C1 [Chen, Zhiyong; Evangelista, Clifford; Lu, X. -C. May; Tortella, Frank] Walter Reed Army Inst Res, Silver Spring, MD USA. [Clarke, Diana; Sing, George] Stemnion Inc, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2008 VL 25 IS 7 MA P307 BP 930 EP 930 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 326BX UT WOS:000257634000313 ER PT J AU McClung, JP Andersen, NE Tarr, TN Stahl, CH Young, AJ AF McClung, James P. Andersen, Nancy E. Tarr, Tyson N. Stahl, Chad H. Young, Andrew J. TI Physical activity prevents augmented body fat accretion in moderately iron-deficient rats SO JOURNAL OF NUTRITION LA English DT Article ID BONE; EXERCISE; ZINC; DIET; ADOLESCENTS; PREVALENCE; STRENGTH; CALCIUM; RESTRICTION; ABSORPTION AB Recent studies describe an association between poor iron status and obesity in humans, although the mechanism explaining this relationship is unclear. The present study aimed to determine the effect of moderate iron deficiency and physical activity (PA) on body composition in an animal model. Male Sprague-Dawley rats consumed iron-adequate (IA; 40 mg/kg) or moderately iron-deficient (ID; 9 mg/kg) diets ad libitum for 12 wk. Rats were assigned to 4 treatment groups (n = 10 per group): IA, sedentary (IAS); IA, PA (IAPA); ID, sedentary (IDS); or ID, PA (IDPA). Activity involved running on motorized running wheels at 4 m/min for 1 h/d for 5 d/wk. After 12 wk, ID rats were not anemic, but body iron stores were reduced as indicated by diminished (P < 0.05) femur iron compared with IA rats. Treatment group did not affect body weight or feed consumption. However, fat mass was greater (P< 0.05) in IDS rats (38.6 +/- 6.7%) than IAS (31.8 +/- 2.9%), IAPA (31.8 +/- 2.0%), and IDPA (32.8 +/- 4.5%) rats. Furthermore, lean body mass was diminished in IDS rats (58.7 +/- 6.8%) compared with IAS (65.6 +/- 3.0%), IAPA (65.6 +/- 2.1 %), and IDPA (64.7 +/- 4.5%) rats. Thus, moderate iron deficiency may cause increased body fat accretion in rats and PA attenuates that effect. C1 [McClung, James P.; Andersen, Nancy E.; Tarr, Tyson N.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Stahl, Chad H.] N Carolina State Univ, Dept Anim Sci, Raleigh, NC 27695 USA. RP McClung, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM james.mcclung@na.amedd.army.mil RI McClung, James/A-1989-2009 NR 35 TC 9 Z9 9 U1 0 U2 2 PU AMER SOC NUTRITIONAL SCIENCE PI BETHESDA PA 9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA SN 0022-3166 J9 J NUTR JI J. Nutr. PD JUL PY 2008 VL 138 IS 7 BP 1293 EP 1297 PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 322AK UT WOS:000257347400006 PM 18567750 ER PT J AU Roundy, S Almony, J Zislis, T AF Roundy, Shad Almony, Jeffrey Zislis, Theodore TI Cutaneous leishmaniasis of the lower lip in a United States soldier SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article C1 [Roundy, Shad; Almony, Jeffrey; Zislis, Theodore] Womack Army Med Ctr, Oral & Maxillofacial Surg Clin, Oral & Maxillofacial Surg Serv, Ft Bragg, NC 28310 USA. RP Roundy, S (reprint author), Womack Army Med Ctr, Oral & Maxillofacial Surg Clin, Oral & Maxillofacial Surg Serv, Ft Bragg, NC 28310 USA. EM shad.roundy@us.army.mil NR 9 TC 2 Z9 2 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUL PY 2008 VL 66 IS 7 BP 1513 EP 1515 DI 10.1016/j.joms.2007.12.045 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 321KN UT WOS:000257303700031 PM 18571042 ER PT J AU Thelen, MD Dauber, JA Stoneman, PD AF Thelen, Mark D. Dauber, James A. Stoneman, Paul D. TI The clinical efficacy of Kinesio Tape for shoulder pain: A randomized, double-blinded, clinical trial SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE impingement; rehabilitation; taping ID SUBACROMIAL IMPINGEMENT SYNDROME; DISABILITY INDEX; PATELLOFEMORAL PAIN; PROPRIOCEPTION; ANKLE; REHABILITATION; ACUPUNCTURE; CONSTRUCT; VALIDITY AB STUDY DESIGN: Prospective, randomized, double-blinded, clinical trial using a repeated-measures design. OBJECTIVES: To determine the short-term clinical efficacy of Kinesio Tape (KT) when applied to college students with shoulder pain, as compared to a sham tape application. BACKGROUND: Tape is commonly used as an adjunct for treatment and prevention of musculoskeletal injuries. A majority of tape applications that are reported in the literature involve non-stretch tape, The KT method has gained significant popularity in recent years, but there is a paucity of evidence on its use. METHODS AND MEASURES: Forty-two subjects clinically diagnosed with rotator cuff tendonitis/impingement were randomly assigned to 1 of 2 groups: therapeutic KT group or sham group. Subjects wore the tape for 2 consecutive 3-day intervals. Self-reported pain and disability and pain-free active range of motion (ROM) were measured at multiple intervals to assess for differences between groups. RESULTS: The therapeutic KT group showed immediate improvement in pain-free shoulder abduction (mean +/- SD increase, 16.9 degrees +/- 23.2 degrees; P =.005) after tape application. No other differences between groups regarding ROM, pain, or disability scores at any time interval were found. CONCLUSION: KT may be of some assistance to clinicians in improving pain-free active ROM immediately after tape application for patients with shoulder pain. Utilization of KT for decreasing pain intensity or disability for young patients with suspected shoulder tendonitis/impingement is not supported. C1 [Thelen, Mark D.] USA, Winn Community Hosp, Phys Therapy Serv, Ft Stewart, GA USA. [Dauber, James A.] Phys & Occupat Therapy Serv, Eglin AFB, FL USA. [Stoneman, Paul D.] US Mil Acad, US Mil Baylor Univ Postprofess Sports Med Phy The, West Point, NY 10996 USA. RP Thelen, MD (reprint author), 331 Shady Oak Circle, Richmond Hill, GA 31324 USA. EM mark.thelen@us.army.mil NR 39 TC 144 Z9 157 U1 8 U2 59 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUL PY 2008 VL 38 IS 7 BP 389 EP 395 DI 10.2519/jospt.2008.2791 PG 7 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 327IW UT WOS:000257723800001 PM 18591761 ER PT J AU Morris, GR Prasanna, VK AF Morris, Gerald R. Prasanna, Viktor K. TI A pipelined-loop-compatible architecture and algorithm to reduce variable-length sets of floating-point data on a reconfigurable computer SO JOURNAL OF PARALLEL AND DISTRIBUTED COMPUTING LA English DT Article DE FPGA; pipeline; reduction; accumulator; sparse matrix; iterative solver; reconfigurable computer AB Reconfigurable computers (RCs) combine general-purpose processors (GPPs) with field programmable gate arrays (FPGAs). The FPGAs are reconfigured at run time to become application-specific processors that collaborate with the GPPs to execute the application. High-level language (HLL) to hardware description language (HDL) compilers allow the FPGA-based kernels to be generated using HLL-based programming rather than HDL-based hardware design. Unfortunately, the loops needed for floating-point reduction operations often cannot be pipelined by these HLL-HDL compilers. This capability gap prevents the development of a number of important FPGA-based kernels. This article describes a novel architecture and algorithm that allow the use of an HLL-HDL environment to implement high-performance FPGA-based kernels that reduce multiple, variable-length sets of floating-point data. A sparse matrix iterative solver is used to demonstrate the effectiveness of the reduction kernel. The FPGA-augmented version running on a contemporary RC is up to 2.4 times faster than the software-only version of the same solver running on the GPP. Conservative estimates show the solver will run up to 6.3 times faster than software on a next-generation RC. Published by Elsevier Inc. C1 [Morris, Gerald R.] USA, Engn Res & Dev Ctr, Major Shared Resource Ctr, Vicksburg, MS 39180 USA. [Prasanna, Viktor K.] Univ So Calif, Dept Elect Engn, Los Angeles, CA 90089 USA. RP Morris, GR (reprint author), USA, Engn Res & Dev Ctr, Major Shared Resource Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM gerald.r.morris@us.army.mil; prasanna@usc.edu NR 25 TC 4 Z9 4 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0743-7315 EI 1096-0848 J9 J PARALLEL DISTR COM JI J. Parallel Distrib. Comput. PD JUL PY 2008 VL 68 IS 7 BP 913 EP 921 DI 10.1016/j.jpdc.2008.03.004 PG 9 WC Computer Science, Theory & Methods SC Computer Science GA 313QV UT WOS:000256756000003 ER PT J AU Madigan, WP Raymond, WR Wroblewski, KJ Thebpatiphat, N Birdsong, RH Jaafar, MS AF Madigan, William P. Raymond, William R. Wroblewski, Keith J. Thebpatiphat, Nuthida Birdsong, Richard H. Jaafar, Mohamad S. TI A review of pediatric uveltis: Part II. Autoimmune diseases and treatment modalities SO JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS LA English DT Review ID INFLAMMATORY-BOWEL-DISEASE; NECROSIS-FACTOR-ALPHA; JUVENILE IDIOPATHIC ARTHRITIS; POSNER-SCHLOSSMAN-SYNDROME; KOYANAGI-HARADA SYNDROME; ACUTE ANTERIOR UVEITIS; ISCHEMIC OPTIC NEUROPATHY; SYMPATHETIC OPHTHALMIA; TUBULOINTERSTITIAL NEPHRITIS; RHEUMATOID-ARTHRITIS AB Uveitis is a manifestation of complex processes that can represent an infectious process or a dysfunction of the immune system that may have grave effects on the eye. Although infectious causes, once properly identified, may be successfully treated by addressing the inciting organism with recognized interventions, the immune-modulated chronic forms of uveitis often provide more complex challenges in management. Recent strides in understanding the inflammatory pathway and better bioengineering capabilities have resulted in some new modalities of treatment. C1 [Madigan, William P.; Thebpatiphat, Nuthida; Jaafar, Mohamad S.] Childrens Natl Med Ctr, Washington, DC 20011 USA. [Raymond, William R.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. [Wroblewski, Keith J.] NEI, NIH, Bethesda, MD 20892 USA. [Birdsong, Richard H.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Madigan, WP (reprint author), Childrens Natl Med Ctr, 111 Michigan Ave NW, Washington, DC 20011 USA. NR 153 TC 6 Z9 6 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0191-3913 J9 J PEDIAT OPHTH STRAB JI J. Pediatr. Ophthalmol. Strabismus. PD JUL-AUG PY 2008 VL 45 IS 4 BP 202 EP 219 PG 18 WC Ophthalmology; Pediatrics SC Ophthalmology; Pediatrics GA 326VI UT WOS:000257686700003 PM 18705618 ER PT J AU Kocifaj, M Kundracik, F Videen, G AF Kocifaj, Miroslav Kundracik, Frantisek Videen, Gorden TI Optical properties of single mixed-phase aerosol particles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article DE light scatteriiig; coated particles; Gaussian p irticlcs; discrete dipole approxiination; effective medium theory ID DISCRETE-DIPOLE APPROXIMATION; LIGHT-SCATTERING; GAUSSIAN PARTICLES; SIZE DISTRIBUTION; EXTINCTION; ABSORPTION; INCLUSION AB We examine the light scattering from wet aerosol particles whose core morphology is a random Gaussian sphere coated by different amounts of water. We compare the results with those calculated from a concentric-sphere particle and from a homogeneous-sphere particle whose refractive index is determined from the Bruggeman mixing rule. In nearly all cases the differences between those of the Gaussian-core and the concentric-sphere particles are small. The most significant differences are seen in calculations of the asymmetry parameters and the intensity and polarization phase functions. The results of the homogeneous-sphere particles vary significantly from those of the Gaussian-core particles, typically an order of magnitude greater than for the concentric-sphere particles. It is not uncommon to see differences of 10% in the efficiencies of large, homogeneous-sphere particles; whereas, in the intensity and polarization phase functions, differences of several tens of percent are not uncommon. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Kocifaj, Miroslav] Slovak Acad Sci, Astron Inst, Bratislava 84504, Slovakia. [Kundracik, Frantisek] Comenius Univ, FMPI, Dept Expt Phys, Bratislava 84248, Slovakia. [Videen, Gorden] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Kocifaj, M (reprint author), Slovak Acad Sci, Astron Inst, Dubravska Cesta 9, Bratislava 84504, Slovakia. EM kocifaj@savba.sk; kundracik@fmph.uniba.sk; gorden.videen@us.army.mil NR 29 TC 13 Z9 13 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL PY 2008 VL 109 IS 11 BP 2108 EP 2123 DI 10.1016/j.jqsrt.2008.03.006 PG 16 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 325OD UT WOS:000257597300014 ER PT J AU Koenig, CA Benardot, D Cody, M Thompson, WR AF Koenig, Chad A. Benardot, Dan Cody, Mildred Thompson, Walter R. TI COMPARISON OF CREATINE MONOHYDRATE AND CARBOHYDRATE SUPPLEMENTATION ON REPEATED JUMP HEIGHT PERFORMANCE SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE high-intensity exercise; caloric supplement; ergogenic aid; exercise performance; glycolysis ID RESISTANCE EXERCISE; SPRINT PERFORMANCE; MUSCLE METABOLISM; SHORT-DURATION; GLYCOGEN; INTERMITTENT; POWER; HABITS; ENERGY; SINGLE AB Koenig, CA, Benardot, D, Cody, M, and Thompson, WR. Comparison of creatine monohydrate and carbohydrate supplementation on repeated jump height performance. J Strength Cond Res 22: 1081-1086, 2008-Creatine monohydrate (CrMH) supplementation aids the ability to maintain performance during repeated bouts of high-intensity exercise, including jump performance. However, carbohydrate supplementation may also provide similar benefits and is less expensive. This study compared the effects of an energy-free placebo, 2 different caloric concentrations of carbohydrate drinks, and a CrMH supplement on repeated jump heights. Sixty active males (mean age, 22 +/- 3.2 years) performed 2 sets of countermovement static jump height tests (10 jumps over 60 seconds) separated by 5 days to determine the differential effects of the placebo, carbohydrate, and CrMH on jump height sustainability over 10 jumps. Subjects were randomly assigned to groups (15 subjects per group) to receive daily doses (x5 days) of carbohydrate drinks containing 100 or 250 kilocalories (kcal), a 25-g CrMH supplement, or an energy-free placebo. After 5 days, the CrMH group experienced a significant weight gain (+1.52; +/- 0.89 kg, p < 0.01), while the other groups did not. The 2 levels of carbohydrate and CrMH supplements were all significantly better at sustaining jump height than the energy-free placebo over the final 3-4 jumps. The 250-kcal carbohydrate-supplemented group experienced a level of benefit (p < 0.01) that was at least equal to that of the CrMH group (p < 0.05), suggesting that the higher dose of carbohydrate was as effective as CrMH in maintaining repeated bouts of high-intensity activity as measured by repeated static jumps. Given the equivalent performance improvement and the absence of weight gain, the carbohydrate supplementation could be considered the preferred option for weight-conscious power athletes involved in activities that require repeated-motion high-intensity activities. C1 [Koenig, Chad A.; Benardot, Dan; Cody, Mildred; Thompson, Walter R.] Georgia State Univ, Coll Hlth & Human Sci, Div Nutr, Atlanta, GA 30303 USA. [Koenig, Chad A.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Benardot, Dan; Thompson, Walter R.] Georgia State Univ, Lab Elite Athlete Performance, Atlanta, GA 30303 USA. [Benardot, Dan; Thompson, Walter R.] Georgia State Univ, Coll Educ, Dept Kinesiol & Hlth, Atlanta, GA 30303 USA. RP Koenig, CA (reprint author), Georgia State Univ, Coll Hlth & Human Sci, Div Nutr, Atlanta, GA 30303 USA. EM Chad.Koenig@us.army.mil NR 31 TC 6 Z9 6 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD JUL PY 2008 VL 22 IS 4 BP 1081 EP 1086 DI 10.1519/JSC.0b013e31816a58c6 PG 6 WC Sport Sciences SC Sport Sciences GA 513JF UT WOS:000271317800008 PM 18545204 ER PT J AU Blaha, MD Leon, LR AF Blaha, Michael D. Leon, Lisa R. TI Effects of indomethacin and buprenorphine analgesia on the postoperative recovery of mice SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID ORALLY-ADMINISTERED BUPRENORPHINE; RATS RATTUS-NORVEGICUS; ABDOMINAL-SURGERY; DRINKING-WATER; PAIN; LAPAROTOMY; CARPROFEN; BEHAVIOR; ACETAMINOPHEN; RESPONSES AB Buprenorphine (Bup) is the most commonly used analgesic in mice, yet few objective assessments address its superiority for postsurgical recovery. In mice, IP implantation of a radiotelemetry device induces decreases in body weight (BW), food and water intake (FI, WI), core temperature (T(c)), and activity levels that persist approximately 14 d in the absence of analgesia. To compare the efficacy of Bup with that of the nonsteroidal antiinflammatory drug indomethacin (Indo) for postsurgical recovery, male C57BL/6J mice were treated on the day of radiotelemetry implantation with Bup (0.3 mg/kg SC) or Indo (1 mg/kg SC) followed by treatment with Indo (I mg/kg PO) on the next day (Bup-Indo versus Indo-Indo). Responses were compared between treatments in mice implanted with a radiotelemetry device and those that did not undergo surgery. Changes in BW, FI, WI, T(c), and activity were examined throughout 14 d of recovery. Indo-Indo was more efficacious in inhibiting postsurgical BW, FI, and WI reductions, compared with Bup-Indo. Bup also reduced BW and FI in the absence of surgery, indicating a nonspecific effect of this drug on these variables. Indo-Indo treatment was associated with higher activity levels during lights-on-to-lights-off transition periods compared with that observed with Bup-Indo. According to 5 objective measures of surgical recovery, our data suggest that Indo-Indo treatment is more efficacious than is Bup-Indo for postsurgical recovery of radiotelemetry-implanted mice. C1 [Blaha, Michael D.; Leon, Lisa R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Blaha, MD (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. EM michael.blaha@amedd.army.mil NR 36 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD JUL PY 2008 VL 47 IS 4 BP 8 EP 19 PG 12 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 334CH UT WOS:000258199400001 ER PT J AU White, JV Ayoob, KT Benedict, MA Chynoweth, MD Gregoire, M Howard, RL McCool, A Parrott, S Ramsey, SH Thiessen, C Thomsen, KN Bender, T Myers, E Michael, P AF White, Jane V. Ayoob, Keith T. Benedict, Melinda A. Chynoweth, Michele D. Gregoire, Mary Howard, Robert L. McCool, Audrey Parrott, Scott Ramsey, Susan H. Thiessen, Charlotte Thomsen, Kim N. Bender, Tori Myers, Esther Michael, Pam TI Registered dietitians' coding practices and patterns of code use SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article AB Coding, coverage, and reimbursement are vital to the clinical segment of our profession. The objective of this study was to assess understanding and use of the medical nutrition therapy (MNT) procedure codes. Its design was a targeted, cross-sectional, Internet survey. Participants were registered dietitians (RDs) preselected based on Medicare Part B provider status, randomly selected RDs from the American Dietetic Association database based on clinical practice designation, and self-selected RDs. Parameters assessed were knowledge and use of existing MNT and/or alternative procedure codes, barriers to code use/compensation, need for additional codes for existing/emerging services, and practice demographics. Results suggest that MNT is being reimbursed for a variety of diseases and conditions. Many RDs working in clinic settings are undereducated about code use of any kind, reporting that code selection frequently is determined not by the RD providing the service, but by "someone else." Self-employed RDs are less likely to rely on others to administrate paperwork required for reimbursement, including selection of procedure codes for billable nutrition. services. Self-employed RDs are more likely to be reimbursed by private or commercial payers and RDs working in clinic settings are more likely to be reimbursed by Medicare; however, the proportion of Medicare providers in both groups is high. RDs must be knowledgeable and accountable for both the business and clinical side of their nutrition practices; using correct codes and following payers' claims processing policies and procedures. This survey and analysis is a first step in understanding the complex web of relationships between clinical practice, MNT code use, and reimbursement. C1 [White, Jane V.] Univ Tennessee, Dept Family Med, Knoxville, TN 37920 USA. [Ayoob, Keith T.] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10467 USA. [Gregoire, Mary] Rush Univ, Med Ctr, Food & Nutr Serv, Chicago, IL 60612 USA. [Howard, Robert L.] Midtown Nutr, New York, NY USA. [McCool, Audrey] Univ Nevada, William F Harrah Coll Hotel Adm, Las Vegas, NV 89154 USA. [Ramsey, Susan H.] Sodexho Hlth Care Serv, Washington Crossing, PA USA. [Thiessen, Charlotte] US Dept Vet Affairs, Nebraska Western Iowa Healthcare Syst, Omaha, NE USA. [Thomsen, Kim N.] USA, Med Command Headquarters, Ft Sam Houston, TX USA. [Bender, Tori; Michael, Pam] Amer Dietet Assoc, Nutr Serv Coverage Team, Chicago, IL USA. [Myers, Esther] Amer Dietet Assoc, Sci Affairs & Res Team, Chicago, IL USA. RP White, JV (reprint author), Univ Tennessee, Dept Family Med, 1924 Alcoa Hwy, Knoxville, TN 37920 USA. EM jwhite13@utk.edu NR 2 TC 1 Z9 1 U1 0 U2 0 PU AMER DIETETIC ASSOC PI CHICAGO PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 USA SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD JUL PY 2008 VL 108 IS 7 BP 1242 EP 1248 DI 10.1016/j.jada.2008.04.015 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 321KG UT WOS:000257303000030 PM 18589037 ER PT J AU Lewicki, DG Heath, GF Filler, RR Slaughter, SC Fetty, J AF Lewicki, David G. Heath, Gregory F. Filler, Robert R. Slaughter, Stephen C. Fetty, Jason TI Face gear surface durability investigations SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 63rd Annual Forum of the American-Helicopter-Society CY MAY 01-03, 2007 CL Virginia Beach, VA SP Amer Helicopter Soc ID HELICOPTER TRANSMISSIONS; GEOMETRY; DRIVES AB Experimental fatigue tests were performed to determine the surface durability life of a face gear in mesh with a tapered spur involute pinion. Twenty-four sets of gears were tested at three load levels: 7200, 8185, and 9075 lb-inch face gear torque, and 2190-3280 rpm face gear speed. The gears were carburized and ground, shot-peened and vibro-honed, and made from vacuum induction melting-vacuum arc remelting Pyrowear 53 steel per AMS 6308. The tests produced 17 gear tooth-spalling failures and 7 suspensions. For all the failed sets, spalling occurred on at least one tooth of all the pinions. In some cases, the spalling initiated a crack in the pinion teeth that progressed to tooth fracture. Also, spalling occurred on some face gear teeth. The American Gear Manufacturing Association endurance allowable stress for a tapered spur involute pinion in mesh with a face gear was determined to be 275 ksi for the material tested. C1 [Lewicki, David G.] USA, Res Lab, Cleveland, OH USA. [Filler, Robert R.] Boeing Co, Mesa, AZ USA. [Fetty, Jason] USA, Aviat Appl Technol Directorate, Ft Eustis, VA USA. RP Lewicki, DG (reprint author), Amer Helicopter Soc 63 Annual Forum, Virginia Beach, VA USA. EM david.g.lewicki@nasa.gov NR 27 TC 1 Z9 1 U1 1 U2 10 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2008 VL 53 IS 3 BP 282 EP 289 PG 8 WC Engineering, Aerospace SC Engineering GA 336HB UT WOS:000258353800006 ER PT J AU Fox, CJ Gillespie, DL Cox, ED Kragh, JF Mehta, SG Salinas, J Holcomb, JB AF Fox, Charles J. Gillespie, David L. Cox, E. Darrin Kragh, John F. Mehta, Sumeru G. Salinas, Jose Holcomb, John B. TI Damage control resuscitation for vascular surgery in a Combat Support Hospital SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE vascular trauma; management; damage control resuscitation ID REQUIRING MASSIVE TRANSFUSION; TRAUMA PATIENTS; EARLY COAGULOPATHY; LOWER-EXTREMITY; FACTOR VIIA; MORTALITY; INJURY; EXPERIENCE; MANAGEMENT; WOUNDS AB Background. Hemorrhage from extremity wounds is a leading cause of potentially preventable death during modern combat operations. Optimal management involves rapid hemostasis and reversal of metabolic derangements utilizing damage control principles. The traditional practice of damage control surgery favors a life over limb approach and discourages elaborate, prolonged vascular reconstructions. We hypothesized that limb preservation could be successful when the damage control approach combines advanced resuscitative strategies and modern vascular techniques. Methods: Trauma Registry records at a Combat Support Hospital from April to June 2006 were retrospectively reviewed. Patients with life-threatening hemorrhage (defined as >4 units of packed red blood cells) who underwent simultaneous revascularization for a pulseless extremity were included. Data collection included the initial physiologic parameters in the emergency department (ED), total and 24-hour blood product requirements, and admission physiology and laboratory values in the intensive care unit (ICU). Outcome measures were survival, graft patency, and amputation rate at 7 days. Results: Sixteen patients underwent 20 vascular reconstructions for upper (3) or lower extremity (17) wounds. Patients were hypotensive (blood pressure 1051 60 +/- 29/18), acidotic (pH 7.27 +/- 0.1; BD -7.50 +/- 5.5), and coagulopathic (international normalized ratio 1.3 +/- 0.4) on arrival to the ED and essentially normal upon admission to the ICU, 4 hours later. Vein grafts (19/20, 95%) were used preferentially. Prosthetic grafts (1), shunting and delayed repair (4) or amputation (1) were infrequent. Heparin was not used or limited to a half dose (5/20, 25%). Tourniquets (12/16, 75%) and fasciotomies (13/16, 81%) were routine. Most (75%) received recombinant factor VIIa in the ED and in the operating room. All survived with normalized physiology on arrival in the ICU. Twenty-four-hour crystalloid use averaged 7.1 +/- 3.2 L, whereas packed red blood cells averaged 23 +/- 18 units, and 88% were massively transfused. Median operative time was 4.5 hours (range, 1.7-8.4 hours). Conclusions: Aggressive damage control resuscitation maneuvers in critically injured casualties successfully permitted prolonged, complex extremity revascularization with excellent early limb salvage and graft patency. Recombinant VIIa and liberal resuscitation with fresh whole blood, plasma, platelets and cryoprecipitate, while minimizing crystalloid, allowed limb salvage and did not result in early graft failures. C1 [Fox, Charles J.; Gillespie, David L.; Cox, E. Darrin] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Fox, Charles J.; Gillespie, David L.] Uniformed Serv Univ Hlth Sci, Div Vasc Surg, Bethesda, MD 20814 USA. [Kragh, John F.; Salinas, Jose; Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. [Mehta, Sumeru G.] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA. RP Fox, CJ (reprint author), Walter Reed Army Med Ctr, Dept Surg, Bldg 2,Ward 64,6900 Georgia Ave, Washington, DC 20307 USA. EM Charles.Fox@us.army.mil OI Gillespie, David/0000-0002-4378-9465 NR 32 TC 45 Z9 48 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2008 VL 65 IS 1 BP 1 EP 9 DI 10.1097/TA.0b013e318176c533 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 327ZP UT WOS:000257767300001 PM 18580508 ER PT J AU Chung, KK Blackbourne, LH Renz, EM Cancio, LC Wang, J Park, MS Horvath, EE Albrecht, MC White, CE Wanek, SM Barillo, DJ Wolf, SE Holcomb, JB AF Chung, Kevin K. Blackbourne, Lorne H. Renz, Evan M. Cancio, Leopoldo C. Wang, Jingjing Park, Myung S. Horvath, Edward E. Albrecht, Michael C. White, Christopher E. Wanek, Sandra M. Barillo, David J. Wolf, Steven E. Holcomb, John B. TI Global evacuation of burn patients does not increase the incidence of Venous Thromboembolic complications SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE injury; burn; trauma; air travel; deep vein thrombosis; evacuation; global; pulmonary embolism; thromboembolism; venous ID THERMALLY INJURED PATIENTS; AIR-TRAVEL; HYPOBARIC HYPOXIA; COAGULATION; ACTIVATION; THROMBOSIS AB Background: Case-control studies have suggested that air travel may be a risk factor for the development of Venous Thromboembolism (VTE). Burned patients from the current war in Iraq and Afghanistan, are transported across three continents to our Burn Center with total ground and air transport time being approximately 24 hours spread over 3 days to 4 days. We hypothesized global evacuation results in increased VTE rates. Methods: Retrospective review of 1,107 consecutive patients admitted to our burn center from January 2003 to December 2005. Results: In the time period evaluated, no detectible differences were found in incidence of VTE between air-evacuated soldiers and those admitted to our facility from South Texas (1.31 % vs. 0.83%, p = ns). The air-evacuated soldiers were younger (26 7 vs. 41 +/- 19, p < 0.0001) but had a higher incidence of inhalation injury (14.4% vs. 8.0%, p < 0.0001) and higher Injury Severity Score (10.9 +/- 13.0 vs. 6.5 +/- 9.2, p < 0.0001). No difference in average percent total body surface area involvement was found (15.8 +/- 19.4 vs. 15.5 +/- 18.4, p = ns). Overall, 11 of 1,107 (0.99%) burned patients developed VTE. Conclusion: Prolonged global evacuation is not associated with increased risk of VTE. C1 [Chung, Kevin K.; Blackbourne, Lorne H.; Renz, Evan M.; Cancio, Leopoldo C.; Park, Myung S.; Horvath, Edward E.; Albrecht, Michael C.; White, Christopher E.; Wanek, Sandra M.; Barillo, David J.; Wolf, Steven E.; Holcomb, John B.] USA, Inst Surg Res, Clin Div, Ft Sam Houston, TX 78234 USA. [Wang, Jingjing] USA, Inst Surg Res, Div Res, Ft Sam Houston, TX 78234 USA. RP Chung, KK (reprint author), 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM kevin.chung@us.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 12 TC 15 Z9 15 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2008 VL 65 IS 1 BP 19 EP 24 DI 10.1097/TA.0b013e3181271b8a PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 327ZP UT WOS:000257767300003 PM 18580524 ER PT J AU Moon, CH Lee, G Judd, D Johnson, E Morrison, CA AF Moon, Christopher H. Lee, Gregory Judd, Daniel Johnson, Eric Morrison, Chet A. TI Hernia development after traumatic injury to the pelvic ilium: Case report and novel approach to repair SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID BONE-GRAFT DEFECT; ILIAC-BONE; BOWEL HERNIATION; LUMBAR HERNIA; DONOR SITES; FRACTURE C1 [Moon, Christopher H.; Lee, Gregory; Judd, Daniel; Johnson, Eric; Morrison, Chet A.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Morrison, CA (reprint author), Michigan State Univ, Dept Surg, 1200 E Michigan Ave,Suite 655, Lansing, MI 48912 USA. EM chet.morrison@ht.msu.edu NR 23 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2008 VL 65 IS 1 BP 231 EP 233 DI 10.1097/01.ta.0000195456.23031.33 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 327ZP UT WOS:000257767300040 PM 17429329 ER PT J AU Babikian, S Thoma, DC Berkey, BD AF Babikian, Sarkis Thoma, David C. Berkey, Bryan D. TI Ruptured ectopic pregnancy presenting 3 years after supracervical hysterectomy SO JOURNAL OF ULTRASOUND IN MEDICINE LA English DT Article ID TOTAL VAGINAL HYSTERECTOMY; ABDOMINAL PREGNANCY AB An ectopic pregnancy after a hysterectomy is a rare event, with about 40 reported cases since it was first identified by Wendeler in 1895.(1) There are even fewer cases reported of an ectopic pregnancy occurring years after a hysterectomy has been performed. This case illustrates the sonographic and computed tomographic (CT) findings in the setting of abdominal pain in a woman of childbearing age and highlights the need to obtain a urine pregnancy test as part of the workup for abdominal pain in women, even if a history of a hysterectomy has been given. Many providers may automatically exclude an ectopic pregnancy as a possibility in the aforementioned clinical scenario if the patient has a history of a hysterectomy. Such automatic exclusion may result in life-threatening consequences. C1 [Babikian, Sarkis; Berkey, Bryan D.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Babikian, Sarkis; Thoma, David C.; Berkey, Bryan D.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP Babikian, S (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM s8sbabikian@usuhs.mil NR 18 TC 9 Z9 9 U1 0 U2 1 PU AMER INST ULTRASOUND MEDICINE PI LAUREL PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906 USA SN 0278-4297 J9 J ULTRAS MED JI J. Ultrasound Med. PD JUL PY 2008 VL 27 IS 7 BP 1087 EP 1090 PG 4 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 321IS UT WOS:000257298600014 PM 18577674 ER PT J AU Hudak, SJ Mora, RV AF Hudak, Steven J. Mora, Rafael V. TI Unilateral ureteral obstruction due to a migrated inflatable penile prosthesis reservoir SO JOURNAL OF UROLOGY LA English DT Editorial Material C1 [Hudak, Steven J.; Mora, Rafael V.] Brooke Army Med Ctr, Dept Surg, Urol Serv, Ft Sam Houston, TX 78234 USA. RP Hudak, SJ (reprint author), Brooke Army Med Ctr, Dept Surg, Urol Serv, Ft Sam Houston, TX 78234 USA. NR 1 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUL PY 2008 VL 180 IS 1 BP 336 EP 336 DI 10.1016/j.juro.2008.03.160 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 312BK UT WOS:000256643900093 PM 18495172 ER PT J AU Boniche, I Morgan, BC Taylor, PJ Meyer, CD Arnold, DP AF Boniche, I. Morgan, B. C. Taylor, P. J. Meyer, C. D. Arnold, D. P. TI Process development and material characterization of polycrystalline Bi2Te3, PbTe, and PbSnSeTe thin films on silicon for millimeter-scale thermoelectric generators SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article; Proceedings Paper CT 54th AVS International Symposium and Exhibition CY OCT 14-19, 2007 CL Seattle, WA SP AVS ID LEAD-TELLURIDE; ALLOYS; FABRICATION AB In this work, deposition, patterning, and metallization of vapor-deposited polycrystalline thermoelectric (TE) thin films of Bi2Te3, PbTe, and PbSnSeTe on silicon (Si) substrates are investigated. These fundamental microfabrication methods are intended for use in integrating TE films into thermally powered micro-electro-mechanical systems (MEMS)-based power generators. P-type polycrystalline Bi2Te3, PbTe, and PbSnSeTe films were successfully deposited on thermally oxidized (100) Si substrates to thicknesses ranging from 0.4 to 9 Am. Dry etch rates of about 0.6-0.7 mu m/min were achieved for Bi2Te3 and PbTe/PbSnSeTe using methane-based gases. Wet etch rates of similar to 3 mu m/min were achieved using various acid wet chemistries. Films were electrically characterized using van der Pauw and transfer length method (TLM) test structures. Postdeposition resistivities were measured as low as 23 m Omega cm for Bi2Te3, 134 m Omega cm for PbTe, and 52 m Omega cm for PbSnSeTe. The Seebeck coefficients were measured at up to 94 mu V/ K for undoped Bi2Te3, and 160 and 42 mu V/K for doped PbTe and PbSnSeTe, respectively. Metal contact resistivities (0. 18 -42 m Omega cm(2)) were also extracted for a variety of thin film metals (Pt, Au, Cu, Ni, Cr/Pt/Au, Ti/Pt). Various postdeposition annealing treatments were explored for reducing film resistivity that would enable higher power delivery for TE generator applications. Rapid thermal annealing in nitrogen at 400 degrees C was shown to reduce the resistivity of PbTe and improve film adhesion to oxidized silicon substrates. Also, after successive heatings in air at 200 degrees C, the resistivity of the PbTe films remained stable while that of the PbSnSeTe increased up to 10X. (C) 2008 American Vacuum Society. C1 [Boniche, I.; Meyer, C. D.; Arnold, D. P.] Univ Florida, Interdisciplinary Microsyst Grp, Gainesville, FL 32611 USA. [Morgan, B. C.; Taylor, P. J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Boniche, I (reprint author), Univ Florida, Interdisciplinary Microsyst Grp, 229 Benton Hall, Gainesville, FL 32611 USA. EM iboniche@ufl.edu RI Arnold, David/F-5947-2013 NR 22 TC 10 Z9 10 U1 3 U2 16 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD JUL-AUG PY 2008 VL 26 IS 4 BP 739 EP 744 DI 10.1116/1.2841522 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 323DM UT WOS:000257424200031 ER PT J AU Edelstein, AS Burnette, J Fischer, GA Cheng, SF Egelhoff, WF Pong, PWT McMichael, RD Nowak, ER AF Edelstein, A. S. Burnette, J. Fischer, G. A. Cheng, S. F. Egelhoff, W. F., Jr. Pong, P. W. T. McMichael, R. D. Nowak, E. R. TI Advances in magnetometry through miniaturization SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article; Proceedings Paper CT 54th AVS International Symposium and Exhibition CY OCT 14-19, 2007 CL Seattle, WA SP AVS ID ROOM-TEMPERATURE; MAGNETIC SENSORS; MAGNETORESISTANCE; NOISE; FLUCTUATIONS AB Recent innovations may lead to magnetic sensors that are smaller, more sensitive, and/or cost less than current magnetometers. Examples of this are the chip scale atomic magnetometer, magnetic tunnel junctions with MgO barriers, and a device for minimizing the effect of I If noise, the microelectromechanical system (MEMS) flux concentrator. In the chip scale atomic magnetometer, researchers have been able to fabricate the light source, optics, heater, optical cell, and photodiode detector in a stack that passes through a silicon wafer. Theoretical and subsequent experimental work has led to the observation of magnetoresistance values of 400% at room temperature in magnetic tunnel junctions with MgO barriers. This large magnetoresistance occurs because electrons in the majority band can tunnel more easily through the MgO barrier than electrons in the minority band. The MEMS flux concentrator has the potential to increase the sensitivity of magnetic sensors at low frequencies by more than an order of magnitude. The MEMS flux concentrator does this by shifting the operating frequency to higher frequencies where the I If noise is much smaller. The shift occurs because the motion of flux concentrators on MEMS flaps modulates the field at kilohertz frequencies at the position of the sensor. Though miniaturization is generally beneficial, trade-offs are necessary because some properties, such as noise, worsen with decreasing size. (C) 2008 American Vacuum Society. C1 [Edelstein, A. S.; Burnette, J.; Fischer, G. A.] USA, Res Lab, Adelphi, MD 20783 USA. [Cheng, S. F.] USN, Res Lab, Washington, DC 20375 USA. [Egelhoff, W. F., Jr.; Pong, P. W. T.; McMichael, R. D.] NIST, Gaithersburg, MD 20899 USA. [Nowak, E. R.] Univ Delaware, Newark, DE 19716 USA. RP Edelstein, AS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM edelstein@arl.army.mil RI McMichael, Robert/J-8688-2012; OI McMichael, Robert/0000-0002-1372-664X NR 25 TC 8 Z9 9 U1 1 U2 11 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 EI 1520-8559 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD JUL-AUG PY 2008 VL 26 IS 4 BP 757 EP 762 DI 10.1116/1.2841516 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 323DM UT WOS:000257424200034 ER PT J AU Ewing, DJ Derenge, MA Shah, PB Lee, U Zheleva, TS Jones, KA AF Ewing, D. J. Derenge, M. A. Shah, P. B. Lee, U. Zheleva, T. S. Jones, K. A. TI Improvement in GaN and AlGaN/GaN Schottky diode performance by reduction in epitaxial film dislocation density SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID ELECTRON-MOBILITY TRANSISTORS; MOLECULAR-BEAM EPITAXY; REVERSE-BIAS LEAKAGE; GALLIUM NITRIDE; CONTACTS; DEFECTS; SAPPHIRE; BARRIERS; GROWTH; HEMTS AB The electrical characteristics of AlGaN/GaN heterostructures and GaN Schottky diodes were correlated with dislocations and other material defects. GaN epitaxial films were grown using conventional metal organic chemical vapor deposition (MOCVD) and pendeo-epitaxy, while AlGaN/GaN heterostructures were grown using conventional MOCVD. Current-voltage (I-V) measurements displayed a wide variation in ideality factor and reverse leakage current density. Schottky diodes fabricated on the pendeo-epitaxial material displayed improved ideality factor (n=1.35) and leakage current density measured at -2 V (J=54.5 A/cm(2)) compared to conventionally grown GaN (n=1.73,J=117 A/cm(2)). The electrical properties of the Schottky diodes on the AlGaN/GaN heterostructure varied across the sample, showing no spatial dependence. Ideality factor and Schottky barrier height ranged n=1.6-3.0 and phi(B)=0.69-0.87, respectively. Reverse leakage current density at -2 V varied by up to three orders of magnitude. Etch pit density and atomic force microscopy revealed three orders of magnitude reduction in dislocation density for the pendeo-epitaxial GaN compared to conventional GaN, while cathodoluminescence indicated lower defect density for the pendeo-epitaxial GaN. Etch pit density revealed almost an order of magnitude lower dislocation density beneath those diodes with improved characteristics on the AlGaN/GaN heterostructure. (c) 2008 American Vacuum Society. C1 [Ewing, D. J.; Derenge, M. A.; Shah, P. B.; Lee, U.; Zheleva, T. S.; Jones, K. A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Ewing, DJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM kajones@arl.army.mil FU U. S. Army Research Laboratory FX This work was supported in part by an appointment to the U. S. Army Research Laboratory Postdoctoral Fellowship Program administered by Oak Ridge Associated Universities through a contract with the U. S. Army Research Laboratory. NR 28 TC 6 Z9 6 U1 2 U2 8 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD JUL PY 2008 VL 26 IS 4 BP 1368 EP 1372 DI 10.1116/1.2953724 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 338GM UT WOS:000258494400020 ER PT J AU Cai, YH Guo, LD Douglas, TA AF Cai, Yihua Guo, Laodong Douglas, Thomas A. TI Temporal variations in organic carbon species and fluxes from the Chena River, Alaska SO LIMNOLOGY AND OCEANOGRAPHY LA English DT Article ID ARCTIC-OCEAN; URONIC-ACIDS; YUKON RIVER; DISTRIBUTIONS; MATTER; SEA; ABUNDANCE; SEAWATER; CLIMATE; WATERS AB Water samples were collected biweekly from the Chena River, Alaska, during 2005-2006 for analysis of dissolved organic carbon (DOC), dissolved inorganic carbon (DIC), total dissolved carbohydrate (TCHO), including monosaccharide (MCHO) and polysaccharide (PCHO), particulate organic carbon (POC) and its isotopic compositions, and Si(OH)(4). Carbon species exhibit strong temporal variations with elevated DOC, POC, and TCHO but depleted DIC and Si(OH)(4) during the spring freshet and decreased DOC, POC, and TCHO but elevated DIC and Si(OH)(4) concentrations under winter ice. Organic matter is mostly derived from surface soil leaching, whereas DIC and Si(OH)(4) are associated with groundwater and mineral layer leaching. On average, DIC was the predominant carbon species, accounting for 77% +/- 13% of the total carbon pool, whereas DOC and POC comprised 19% +/- 10% and 4% +/- 4%, respectively. However, DOC became the dominant carbon species during the spring freshet. TCHO comprised 15% +/- 4% of DOC with higher CHO: DOC ratios during spring runoff and summer. Within the TCHO pool, MCHO was the predominant CHO component (89% +/- 10%), leaving 11% +/- 10% as PCHO. The particulate organic matter source during the summer drought season was mostly autochthonous, with low POC: chlorophyll a and C: N but high POC: suspended particulate matter ratios and depleted delta C-13 values. The annual yields of DOC, DIC, and POC from the basin are 133 +/- 8, 361 +/- 7, and 27 +/- 4 x 10(3) mol C km(-2), corresponding to an export flux of 6.9 +/- 0.4, 18.8 +/- 0.4, and 1.4 +/- 0.2 x 10(8) mol C yr(-1), respectively. Anticipated changes in hydrological and biogeochemical cycles in high-latitude watersheds undergoing climate warming will likely be reflected in the chemical and phase speciation of carbon and other elements. C1 [Cai, Yihua; Guo, Laodong] Univ So Mississippi, Dept Marine Sci, Stennis Space Ctr, MS 39529 USA. [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. RP Guo, LD (reprint author), Univ So Mississippi, Dept Marine Sci, Stennis Space Ctr, MS 39529 USA. EM Laodong.Guo@usm.edu RI Guo, Laodong/F-6045-2010 OI Guo, Laodong/0000-0002-5010-1630 NR 36 TC 34 Z9 37 U1 1 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0024-3590 EI 1939-5590 J9 LIMNOL OCEANOGR JI Limnol. Oceanogr. PD JUL PY 2008 VL 53 IS 4 BP 1408 EP 1419 DI 10.4319/lo.2008.53.4.1408 PG 12 WC Limnology; Oceanography SC Marine & Freshwater Biology; Oceanography GA 328BY UT WOS:000257773700019 ER PT J AU Perkins, EJ Garcia-Reyero, N Villeneuve, DL Martinovic, D Brasfield, SM Blake, LS Brodin, JD Denslow, ND Ankley, GT AF Perkins, Edward J. Garcia-Reyero, Natalia Villeneuve, Daniel L. Martinovic, Dalma Brasfield, Sandra M. Blake, Lindsey S. Brodin, Jeffrey D. Denslow, Nancy D. Ankley, Gerald T. TI Perturbation of gene expression and steroidogenesis with in vitro exposure of fathead minnow ovaries to ketoconazole SO MARINE ENVIRONMENTAL RESEARCH LA English DT Article; Proceedings Paper CT 14th International Symposium on Pollutant Responses in Marine Organisms (PRIMO 14) CY MAY 06-09, 2007 CL Florianopolis, BRAZIL SP Petroleo Brasileiro S A, Conselho Nacl Desenvolvimento Cientif Tecnol, Soc Brasileira Ecotoxicol, Univ Fed Santa Catarina DE gene expression profiling; ketoconazole; steroidogenesis AB Ketoconazole is a fungicidal drug that inhibits function of cytochrome P450s in the synthesis of steroids. To examine if inhibition of P450 function affects gene expression in a dynamic manner, we conducted in vitro exposures of ovary tissue from fathead minnows (Pimephales promelas) to 0.5 pM ketoconazole to investigate effects on steroid production and gene expression over time. Expression of four key steroiclogenesis genes was examined at 1, 6, and 12 h of exposure. 11 P- and 200-hydroxysteroid clehydrogenases were down regulated at I h and Cytochrome P450 17 was down-regulated at 12 h, consistent with the absence of steroid production. In contrast, cytochrome P450 19A was up-regulated at 6 h, indicating feedback regulation. Microarray analysis of 12 h exposures indicated enrichment of biological processes involved in neurotransmitter secretion, lymphocyte cell activation, sodium ion transport, and embryonic development. These data suggest that, with the exception of cytochrome P450 19A, these steroid metabolic genes are regulated in a feed forward manner and that the effects of ketoconazole may be broader than anticipated based on the mechanism of action alone. Published by Elsevier Ltd. C1 [Perkins, Edward J.; Brasfield, Sandra M.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Garcia-Reyero, Natalia; Denslow, Nancy D.] Univ Florida, Dept Physiol Sci, Gainesville, FL 32610 USA. [Garcia-Reyero, Natalia; Denslow, Nancy D.] Univ Florida, Ctr Environm & Human Toxicol, Gainesville, FL 32610 USA. [Villeneuve, Daniel L.; Martinovic, Dalma; Blake, Lindsey S.; Brodin, Jeffrey D.; Ankley, Gerald T.] US EPA, Mid Continent Ecol Div, Duluth, MN USA. RP Perkins, EJ (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM edwardj.perkins@us.army.mil OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965 NR 8 TC 5 Z9 5 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-1136 J9 MAR ENVIRON RES JI Mar. Environ. Res. PD JUL PY 2008 VL 66 IS 1 BP 113 EP 115 DI 10.1016/j.marenvres.2008.02.072 PG 3 WC Environmental Sciences; Marine & Freshwater Biology; Toxicology SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Toxicology GA 325FX UT WOS:000257575400131 PM 18423573 ER PT J AU Genge, MJ Taylor, S AF Genge, M. J. Taylor, S. TI Barred olivine chondrule fragments among micrometeorites SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT Workshop on Antarctic Meteorites - Search, Recovery, and Classification CY JUL 26-27, 2008 CL Inst Polar Res, Antarctic Meteorite Res Ctr, Matsue, JAPAN SP Natl Inst Polor Res, SOKENDAI, Graduate Univ Adv Studies, Lunar & Planetary Inst, Shimane Prefecture HO Inst Polar Res, Antarctic Meteorite Res Ctr C1 [Genge, M. J.] Univ London Imperial Coll Sci Technol & Med, Dept Earth Sci & Engn, London SW7 2AZ, England. [Taylor, S.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. EM m.genge@imperial.ac.uk NR 3 TC 0 Z9 0 U1 0 U2 0 PU METEORITICAL SOC PI FAYETTEVILLE PA DEPT CHEMISTRY/BIOCHEMISTRY, UNIV ARKANSAS, FAYETTEVILLE, AR 72701 USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD JUL PY 2008 VL 43 IS 7 SU S BP A47 EP A47 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 326TZ UT WOS:000257683100072 ER PT J AU Zubko, E Kimura, H Shkuratov, Y Muinonen, K Yamamoto, T Videen, G AF Zubko, E. Kimura, H. Shkuratov, Yu. Muinonen, K. Yamamoto, T. Videen, G. TI Light scattering by highly absorbing irregularly shaped particles SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT Workshop on Antarctic Meteorites - Search, Recovery, and Classification CY JUL 26-27, 2008 CL Inst Polar Res, Antarctic Meteorite Res Ctr, Matsue, JAPAN SP Natl Inst Polor Res, SOKENDAI, Graduate Univ Adv Studies, Lunar & Planetary Inst, Shimane Prefecture HO Inst Polar Res, Antarctic Meteorite Res Ctr C1 [Zubko, E.] Tohoku Univ, Sendai, Miyagi 980, Japan. [Zubko, E.; Shkuratov, Yu.] Kharkov Natl Univ, Kharkov, Ukraine. [Kimura, H.; Yamamoto, T.] Hokkaido Univ, Sapporo, Hokkaido 060, Japan. [Muinonen, K.] Univ Helsinki, FIN-00014 Helsinki, Finland. [Videen, G.] USA, Res Lab, AMSRL CI EM, Washington, DC 20310 USA. EM zubko@caos-a.geophys.tohoku.ac.jp NR 3 TC 0 Z9 0 U1 0 U2 3 PU METEORITICAL SOC PI FAYETTEVILLE PA DEPT CHEMISTRY/BIOCHEMISTRY, UNIV ARKANSAS, FAYETTEVILLE, AR 72701 USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD JUL PY 2008 VL 43 IS 7 SU S BP A178 EP A178 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 326TZ UT WOS:000257683100333 ER PT J AU De Lorenzo, RA AF De Lorenzo, Robert A. TI Accreditation status of US military graduate medical education programs SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Annual Meeting of the American-College-of-Emergency-Physician Government Services Chapter CY MAR 19-21, 2007 CL San Antonio, TX SP Amer Coll Emergency Phys AB Context: Military graduate medical education (GME) comprises a substantial fraction of U.S. physician training capacity. The wars in Iraq and Afghanistan have placed substantial stress on military medicine, and lay and professional press accounts have raised awareness of the effects on military GME. To date, however, objective data on military GME quality remains sparse. Objective: Determine the accreditation status of U.S. military GME programs. Additionally, military GME program data will be compared to national (U.S.) accreditation lengths. Design: Retrospective review of Accreditation Council for Graduate Medical Education (ACGME) data. Participants: All military-sponsored core programs in specialties with at least three residencies were included. Military-affiliated but civilian-sponsored programs were excluded. Outcome measures: The current and past cycle data were used for the study. For each specialty, the current mean accreditation length and the net change in cycle was calculated. National mean accreditation lengths by specialty for 2005 to 2006 were obtained from the ACGME. Comparison between the overall mean national and military accreditation lengths was performed with a z test. All other comparisons employed descriptive statistics. Results: Ninety-nine military programs in 15 specialties were included in the analysis. During the study period, 1 program was newly accredited, and 6 programs had accreditation withdrawn or were closed. The mean accreditation length of the military programs was 4.0 years. The overall national mean for the same specialties is 3.5 years (p < 0.01). In previous cycles, 68% of programs had accreditation of 4 years or longer, compared to 70% in the current cycle, while 13% had accreditation of 2 years or less in the previous cycle compared to 14% in the current cycle. Ten (68%) of the military specialties had mean accreditation lengths greater than the national average, while 5 (33%) were below it. Ten (68%) specialties had stable or improving cycle lengths when compared to previous cycles. Conclusion: Military GME accreditation cycle lengths are, overall, longer than national averages. Trends show many military programs are experiencing either stable or slightly lengthening accreditation compared to previous cycles. A few specialties show a declining trend. There has been a modest 5% decline in the number of military core residency programs since 2000. C1 [De Lorenzo, Robert A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. RP De Lorenzo, RA (reprint author), Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. NR 20 TC 0 Z9 0 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2008 VL 173 IS 7 BP 635 EP 640 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 328CH UT WOS:000257774600005 PM 18700596 ER PT J AU Barido, GT Campbell-Gauthier, GD Mang-Lawson, AM Mangelsdorff, AD Finstuen, K AF Barido, George T. Campbell-Gauthier, Gail D. Mang-Lawson, Anianda M. Mangelsdorff, A. David Finstuen, Kenn TI Patient satisfaction in military medicine: Model refinement and assessment of continuity of care effects SO MILITARY MEDICINE LA English DT Article ID HEALTH AB The Military Health System (MHS) identified patient-centered care and satisfied beneficiaries as main objectives in their 2006 Strategic Plan. The objective of this study was to expand upon the previous MHS model to determine predictors of patient satisfaction behaviors based upon associated attitudes and beliefs in addition to determining the predictive qualities presented by continuity of care. A sample of 90,318 patient responses from 2002 to 2004 was drawn from the Customer Satisfaction Survey database. Hierarchical Multiple linear regression analyses were conducted to assess the uniquely predictive effects of the independent variables on the outcome variable. Results indicated the constructs from previous studies of satisfaction within the MHS using an attitude model were consistent when tested in a behavioral model. Hypothesis tests also indicated continuity of care demonstrated uniquely predictive qualities suggesting inclusion in the model. The final satisfaction with visit model yielded F-(29,F-90,F-288) = 7062.37, p < 0.01 with R-2 = 0.694. C1 [Barido, George T.; Campbell-Gauthier, Gail D.; Mang-Lawson, Anianda M.; Mangelsdorff, A. David; Finstuen, Kenn] Baylor Univ, USA, Ft Sam Houston, TX 78234 USA. RP Barido, GT (reprint author), 4500 Stuart St, Fort Jackson, SC 29207 USA. EM george.barido@us.army.mil NR 12 TC 4 Z9 4 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2008 VL 173 IS 7 BP 641 EP 646 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 328CH UT WOS:000257774600006 PM 18700597 ER PT J AU Wojcik, BE Humphrey, RJ Fulton, LV Psalmonds, LC Hassell, LH AF Wojcik, Barbara E. Humphrey, Rebecca J. Fulton, Lawrence V. Psalmonds, Linda C. Hassell, L. Harrison TI Comparison of Operation Iraqi Freedom and Patient Workload Generator injury distributions SO MILITARY MEDICINE LA English DT Article AB The Patient Workload Generator (PATGEN) simulation model is an important part of the Army Medical Department force requirement planning. The current version of the PATGEN model is based on historical major combat operations such as World War It and the Korean War. The purpose of this Study was to determine whether there was a significant difference between injury distributions used in the PATGEN model and the injury distributions based on the data from Operation Iraqi Freedom (OIF). To make the comparison feasible, the PATGEN injury categories were created using the Barell Injury Matrix. Analyses were performed using two independent OIF data sources, the Joint Theater Trauma Registry and the Standard Inpatient Data Record. Based on chi(2) test results, both analyses suggest a significant difference between PATGEN and OIF injury distributions. A major concern is the underestimation by PATGEN of battle injuries with multiple wounds. The findings support future use of data-driven diagnosis-based injury distributions for current operations and new more flexible simulation models that will allow for changes in injury probability distributions. C1 [Wojcik, Barbara E.; Humphrey, Rebecca J.; Fulton, Lawrence V.; Psalmonds, Linda C.; Hassell, L. Harrison] USA, Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, Ft Sam Houston, TX 78234 USA. RP Wojcik, BE (reprint author), USA, Med Dept Ctr & Sch, Ctr AMEDD Strateg Studies, 1608 Stanley Rd,Suite 47, Ft Sam Houston, TX 78234 USA. NR 4 TC 2 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2008 VL 173 IS 7 BP 647 EP 652 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 328CH UT WOS:000257774600007 PM 18700598 ER PT J AU Klein, DA Adelman, WP AF Klein, David A. Adelman, William P. TI Adolescent pregnancy in the US military: What we know and what we need to know SO MILITARY MEDICINE LA English DT Article ID CHLAMYDIA-TRACHOMATIS INFECTIONS; ABSTINENCE-ONLY EDUCATION; EARLY SEXUAL-ACTIVITY; WOMENS HEALTH-CARE; DEPENDENT ADOLESCENTS; UNINTENDED PREGNANCY; UNPLANNED PREGNANCY; TEENAGE PREGNANCY; IMPROVED OUTCOMES; PRETERM DELIVERY AB Adolescent pregnancy is a significant public health problem in the United States, but little is known about this condition in military-affiliated populations. This article reviews what is known about adolescent pregnancy among (1) dependent children of active duty and retired personnel and (2) active duty military personnel. Sparse and conflicting evidence exists regarding the prevalence of, the risk factors for, and the impacts of pregnancy in the dependent child population. Limited evidence regarding active duty service members reveals risky behavior by young military personnel, failure to effectively use contraception, and resulting pregnancies that consume military resources and diminish deployability and retention. We suggest research questions for further study that could lead to interventions targeting unintended adolescent pregnancy and its attendant tolls on health, budgets, military readiness, and fighting strength. C1 [Klein, David A.] David Grant Med Ctr, Dept Family Med, Travis AFB, CA 94535 USA. [Adelman, William P.] Walter Reed Army Med Ctr, Dept Pediat & Adolescent Med, Washington, DC 20307 USA. [Adelman, William P.] Natl Naval Med Ctr, Dept Pediat & Adolescent Med, Bethesda, MD 20889 USA. RP Klein, DA (reprint author), David Grant Med Ctr, Dept Family Med, 101 Bodin Circle, Travis AFB, CA 94535 USA. NR 90 TC 13 Z9 13 U1 0 U2 7 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2008 VL 173 IS 7 BP 658 EP 665 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 328CH UT WOS:000257774600009 PM 18700600 ER PT J AU Britch, SC Linthicum, KJ Anyamba, A Tucker, CJ Pak, EW Maloney, FA Cobb, K Stanwix, E Humphries, J Spring, A Pagac, B Miller, M AF Britch, Seth C. Linthicum, Kenneth J. Anyamba, Assaf Tucker, Compton J. Pak, Edwin W. Maloney, Francis A., Jr. Cobb, Kristin Stanwix, Erin Humphries, Jeri Spring, Alexandra Pagac, Benedict Miller, Melissa TI Satellite vegetation index data as a tool to forecast population dynamics of medically important mosquitoes at military installations in the continental United States SO MILITARY MEDICINE LA English DT Article ID RIFT-VALLEY-FEVER; AEDES-ALBOPICTUS; VECTOR; VIRUS; DISEASES; EPIDEMICS; RAINFALL; AFRICA; KENYA; SAHEL AB The United States faces many existing and emerging mosquito-borne disease threats, such as West Nile virus and Rift Valley fever. An important component of strategic prevention and control plans for these and other mosquito-borne diseases is forecasting the distribution, timing, and abundance of mosquito vector populations. Populations of many medically important mosquito species are closely tied to climate, and historical climate-population associations may be used to predict future population dynamics. Using 2003-2005 U.S. Army Center for Health Promotion and Preventive Medicine mosquito surveillance data, we looked at populations of several known mosquito vectors of West Nile virus, as well as possible mosquito vectors of Rift Valley fever virus, at continental U.S. military installations. We compared population changes with concurrent patterns for a satellite-derived index of climate (normalized difference vegetation index) and observed instances of population changes appearing to be direct responses to climate. These preliminary findings are important first steps in developing an automated, climate-driven, early warning system to flag regions of the United States at elevated risk of mosquito-borne disease transmission. C1 [Britch, Seth C.; Linthicum, Kenneth J.] ARS, USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL USA. [Anyamba, Assaf; Tucker, Compton J.; Pak, Edwin W.] NASA, Goddard Space Flight Ctr, Biospher Sci Branch, Greenbelt, MD 20771 USA. [Maloney, Francis A., Jr.] USA, Ctr Hlth Promot & Prevent Med W, Fort Lewis, WA 98433 USA. [Cobb, Kristin; Stanwix, Erin; Humphries, Jeri] USA, Ctr Hlth Promot & Prevent Med S, Fort Lewis, WA 98433 USA. [Spring, Alexandra; Pagac, Benedict; Miller, Melissa] USA, Ctr Hlth Promot & Prevent Med N, Fort George G Meade, MD 20755 USA. RP Britch, SC (reprint author), ARS, USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL USA. NR 28 TC 13 Z9 14 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2008 VL 173 IS 7 BP 677 EP 683 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 328CH UT WOS:000257774600012 PM 18700603 ER PT J AU Nevin, RL Silvestri, JW Hu, Z Tobler, SK Trotta, RF AF Nevin, Remington L. Silvestri, John W. Hu, Zheng Tobler, Steven K. Trotta, Richard F. TI Suspected pulmonary tuberculosis exposure at a remote US Army camp in northeastern Afghanistan, 2007 SO MILITARY MEDICINE LA English DT Article ID WEST FRONTIER PROVINCE; HEALTH-CARE WORKERS; SKIN-TESTS; PAKISTAN; APLISOL; PREVALENCE; RESISTANCE; INFECTION; PRISONERS; REFUGEES AB Military personnel serving at remote camps in the border regions of northeastern Afghanistan may experience crowded living conditions and may have frequent interaction with local national (LN) workers, increasing the risk of exposure to multiple endemic diseases including tuberculosis (TB). In January 2007, pulmonary TB was clinically suspected in a LN worker who had close contact with a company of 92 U.S. Army personnel at a remote camp in Konar province, Afghanistan, over 4 months. This report describes the results of the contact investigation conducted by the U.S. Army, in which four U.S. personnel were found to have evidence of TB exposure. This investigation raises concerns arising from the high prevalence of drug-resistant TB in the region and in neighboring North West Frontier Province, Pakistan, and demonstrates the challenges of conducting contact investigations and using LN workers in deployed wartime environments. C1 [Nevin, Remington L.; Hu, Zheng; Tobler, Steven K.] USA, Med Surveillance Activ, Silver Spring, MD 20910 USA. [Silvestri, John W.] Martin Army Community Hosp, Ft Benning, GA 31905 USA. [Trotta, Richard F.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Nevin, RL (reprint author), USA, Med Surveillance Activ, 2900 Linden Lane,Suite 200, Silver Spring, MD 20910 USA. OI Nevin, Remington/0000-0002-0534-1889 NR 26 TC 4 Z9 4 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2008 VL 173 IS 7 BP 684 EP 688 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 328CH UT WOS:000257774600013 PM 18700604 ER PT J AU Subramanian, PS Birdsong, RH AF Subramanian, Prem S. Birdsong, Richard H. TI Surgical management of traumatic strabismus after combat-related injury SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 32nd Annual Meeting of the North-American-Neuro-Ophthalmology-Society CY FEB 25-MAR 02, 2006 CL Tucson, AZ SP N Amer Neuro Ophthalmol Soc ID NERVE PALSY; FRACTURE; MUSCLE; REPAIR AB Traumatic strabismus may result from orbital or head injury (closed or open). Patients may have other complex injuries that delay diagnosis and treatment. Twelve consecutive adult patients with persistent (>3 month) strabismus after combat-related head, orbital, or eye trauma underwent strabismus surgery on one or both eyes. The main outcome measures were ocular alignment and diplopia resolution at least 6 months postoperatively. Seven of 12 patients (58%) had traumatic vision loss (<20/200) in one eye in addition to the traumatic strabismus. Strabismus procedures were complicated intraoperatively by previous ocular and orbital surgery in the majority of patients. One patient required an additional procedure to obtain a satisfactory result, and all patients achieved resolution of diplopia and/or cosmetic improvement 6 months postoperatively. Acceptable outcomes at 6 months may be obtained by using customary amounts of muscle recession and resection both horizontally and vertically. C1 [Subramanian, Prem S.; Birdsong, Richard H.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. [Subramanian, Prem S.] Uniformed Serv Univ Hlth Sci, Div Ophthalmol, Bethesda, MD 20814 USA. RP Subramanian, PS (reprint author), Wilmer Eye Inst, Neuroophthalmol Unit, 600 N Wolfe St, Baltimore, MD 21287 USA. OI Subramanian, Prem/0000-0001-5824-8322 NR 19 TC 1 Z9 1 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2008 VL 173 IS 7 BP 693 EP 696 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 328CH UT WOS:000257774600015 PM 18700606 ER PT J AU Holmes, RO Tavee, J AF Holmes, Robert O., Jr. Tavee, Jinny TI Vasospasm and stroke attributable to ephedra-free Xenadrine: Case report SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Navy Chapter Meeting of the American-College-of-Physicians CY OCT 11-14, 2006 CL Bethesda, MD SP Amer Coll Phys ID WEIGHT-LOSS; PRESSURE AB Following the 2004 ban of ephedra, which was linked to several cases of stroke and myocardial infarction, manufacturers have marketed "ephedra-free" weight loss products that include the active ingredient synephrine. Despite the lack of data on safety and efficacy, synephrine is touted by its promoters as a "safe" alternative to ephedra and is often combined with caffeine, as in the supplement Xenadrine-EFX. We report a case of left middle cerebral artery vasopasm and stroke in a young healthy patient in the setting of Xenadrine-EFX use. C1 [Holmes, Robert O., Jr.] Walter Reed Army Med Ctr, Silver Spring, MD 20910 USA. [Tavee, Jinny] Cleveland Clin, Cleveland, OH 44195 USA. RP Holmes, RO (reprint author), Walter Reed Army Med Ctr, Silver Spring, MD 20910 USA. NR 18 TC 11 Z9 11 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2008 VL 173 IS 7 BP 708 EP 710 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 328CH UT WOS:000257774600018 PM 18700609 ER PT J AU Ter-Gabrielyan, N Merkle, LD Ikesue, A Dubinskii, M AF Ter-Gabrielyan, Nikolay Merkle, Larry D. Ikesue, Akio Dubinskii, Mark TI Ultralow quantum-defect eye-safe Er : SC2O3 laser SO OPTICS LETTERS LA English DT Article AB Resonantly pumped Er3+:SC2O3 laser operation is achieved with a quantum defect (QD) of 1.5% at liquid nitrogen temperature. The laser, in-line pumped at 1535 nm, operated at 1558 nm with a slope efficiency of over 45%. This is believed to be the lowest QD eye-safe laser ever reported. CW output of over 3.3 W was obtained in this first experiment. (C) 2008 Optical Society of America. C1 [Ter-Gabrielyan, Nikolay; Merkle, Larry D.; Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA. [Ikesue, Akio] World Lab Co Ltd, Atsuta Ku, Nagoya, Aichi 4560023, Japan. RP Dubinskii, M (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil NR 12 TC 38 Z9 38 U1 1 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUL 1 PY 2008 VL 33 IS 13 BP 1524 EP 1526 DI 10.1364/OL.33.001524 PG 3 WC Optics SC Optics GA 331NB UT WOS:000258017800044 PM 18594686 ER PT J AU Hueman, CK Eller, MR AF Hueman, Captain Kevin Eller, Major Robert TI Reduction of anterior frontal sinus fracture involving the frontal outflow tract using balloon sinuplasty SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID SAFETY C1 [Hueman, Captain Kevin; Eller, Major Robert] Brooke Army Med Ctr, Wilford Hall Med Ctr, San Antonio Uniformed Serv Hlth Educ Cosortium, Dept Otolaryngol Head & Neck Surg, Ft Sam Houston, TX 78234 USA. RP Hueman, CK (reprint author), 12314 Hart Cliff, San Antonio, TX 78249 USA. EM kevinhueman@gmail.com NR 3 TC 2 Z9 3 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUL PY 2008 VL 139 IS 1 BP 170 EP 171 DI 10.1016/j.otohns.2008.02.003 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 324PK UT WOS:000257530300034 ER PT J AU Plunkett, AR Buckenmaier, CC AF Plunkett, Anthony R. Buckenmaier, Chester C., III TI Safety of multiple, simultaneous continuous peripheral nerve block catheters in a patient receiving therapeutic low-molecular-weight heparin SO PAIN MEDICINE LA English DT Article DE continuous peripheral nerve block; anticoagulation; trauma; pain management ID LUMBAR PLEXUS BLOCK; REGIONAL ANESTHESIA; ROPIVACAINE; HEMATOMA; INFUSION AB Objective. The application of continuous peripheral nerve block (CPNB) has been an important anesthetic tool in the management of combat soldiers wounded from current conflicts. Placing and maintaining CPNBs becomes a challenge in this patient population due to concomitant prophylactic and therapeutic anti coagulation. Case Report. A 32-year-old male sustained multiple traumatic injuries from an improvised explosive device, including a right tibial fracture, a left tibial fracture, and a left ulnar fracture. His pain was originally well controlled with a left infraclavicular CPNB (0.2% ropivacaine at 10 mL/h with 3 mL bolus every 20 minutes) and an epidural (0.2% ropivacaine at 10 mL/h with 5 mL bolus every 30 minutes). He subsequently developed a common femoral vein thrombus and was treated with low-molecular-weight heparin. His epidural catheter was discontinued;, however, his pain was not well controlled with intravenous and oral pain medication. We elected to place bilateral, tunneled sciatic CPNBs and a left, tunneled femoral CPNB. We started infusions of 0.2% ropivacaine at 10 mL/h in each catheter, in addition to 5 mL every 30 minutes demand dose in each sciatic catheter. The patient's serum ropivacaine levels were analyzed 24 hours after the start of the infusions and were found to be 5.8 mg/L and < 0.1 mg/L for total and free concentrations, respectively. Conclusions. This case highlights the application of simultaneous CPNB techniques in a patient with multiple extremity injuries receiving anticoagulant therapy. C1 [Plunkett, Anthony R.; Buckenmaier, Chester C., III] Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA. RP Plunkett, AR (reprint author), Walter Reed Army Med Ctr, Army Reg Anesthesia & Pain Management Initiat, Anesthesia & Operat Serv, Bldg 2,Ward 44,Room 4418, Washington, DC 20307 USA. EM anthony.plunkett@na.amedd.army.mil NR 15 TC 5 Z9 5 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-2375 EI 1526-4637 J9 PAIN MED JI Pain Med. PD JUL-AUG PY 2008 VL 9 IS 5 BP 624 EP 627 DI 10.1111/j.1526-4637.2008.00418.x PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 334MD UT WOS:000258225000015 PM 18346066 ER PT J AU Hunley, TE Spring, MD Peters, TR Weikert, DR Jabs, K AF Hunley, Tracy E. Spring, Michele D. Peters, Timothy R. Weikert, Douglas R. Jabs, Kathy TI Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome SO PEDIATRIC NEPHROLOGY LA English DT Article DE STEC; thrombotic microangiopathic anemia; thrombotic microangiopathy ID ESCHERICHIA-COLI O157-H7; OF-THE-LITERATURE; EXTRARENAL INVOLVEMENT; ANTIBIOTIC-TREATMENT; GAS-GANGRENE; INFECTION; CHILDREN; SEPSIS; TOXIN; ADENOCARCINOMA AB We report the case of a 19-month-old male child with diarrhea-associated hemolytic uremic syndrome (HUS) who developed swelling of the right arm at the site of a peripherally inserted central venous catheter (PICC), fever, and later, ecchymosis. Wound cultures at the time of surgical debridement grew Clostridium septicum. The child subsequently required amputation of the right arm and prolonged therapy with parenteral penicillin and clindamycin. Clostridium septicum infections in children with HUS have been associated with a high rate of mortality. Along with colon cancer, diarrhea-associated HUS comprises a clinical entity which appears to predispose to atraumatic C. septicum infection, where acidic and anaerobic conditions in the diseased colon favor C. septicum invasion. Though not well recognized among pediatric nephrologists, C. septicum infection constitutes a severe, albeit rare, complication of diarrhea-associated HUS, but one in which a high index of suspicion is warranted as aggressive surgical and antibiotic therapy may be life-saving. C1 [Hunley, Tracy E.; Jabs, Kathy] Monroe Carell Jr Childrens Hosp Vanderbilt, Div Pediat Nephrol, Nashville, TN 37232 USA. [Spring, Michele D.] USN, Med Res Ctr, Walter Reed Army Inst Res, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Peters, Timothy R.] Wake Forest Univ, Sch Med, Sect Pediatric Infect Dis, Winston Salem, NC 27109 USA. [Weikert, Douglas R.] Vanderbilt Univ, Med Ctr, Dept Orthopaed, Nashville, TN USA. RP Hunley, TE (reprint author), Monroe Carell Jr Childrens Hosp Vanderbilt, Div Pediat Nephrol, 11133 Doctors Off Tower,2200 Childrens Way, Nashville, TN 37232 USA. EM tray.hunley@vanderbilt.edu RI Spring, Michele/B-3564-2011 NR 32 TC 7 Z9 7 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0931-041X J9 PEDIATR NEPHROL JI Pediatr. Nephrol. PD JUL PY 2008 VL 23 IS 7 BP 1171 EP 1175 DI 10.1007/s00467-008-0774-5 PG 5 WC Pediatrics; Urology & Nephrology SC Pediatrics; Urology & Nephrology GA 304EB UT WOS:000256091700022 PM 18301926 ER PT J AU Carroll, DW AF Carroll, David W. TI Perspectives in psychiatric consultation liaison nursing - Care of the wounded soldier by a PCLN team SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Editorial Material ID POSTTRAUMATIC-STRESS-DISORDER C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Carroll, DW (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM david.carroll@amedd.army.mil NR 8 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0031-5990 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD JUL PY 2008 VL 44 IS 3 BP 211 EP 215 DI 10.1111/j.1744-6163.2008.00177.x PG 5 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 322OS UT WOS:000257385800010 PM 18577128 ER PT J AU Consolo, G Azzerboni, B Lopez-Diaz, L Gerhart, G Bankowski, E Tiberkevich, V Slavin, AN AF Consolo, G. Azzerboni, B. Lopez-Diaz, L. Gerhart, G. Bankowski, E. Tiberkevich, V. Slavin, A. N. TI Micromagnetic study of the above-threshold generation regime in a spin-torque oscillator based on a magnetic nanocontact magnetized at an arbitrary angle SO PHYSICAL REVIEW B LA English DT Article ID ELECTRIC-CURRENT; MULTILAYER; EXCITATION; WAVES AB The nature and the above-threshold behavior of spin-wave modes excited by spin-polarized direct current in a spin-torque auto-oscillator based on a magnetic nanocontact was studied by a micromagnetic simulation in the case when the external bias magnetic field was rotated from the in-plane to perpendicular-to-plane orientation. In qualitative agreement with the weakly nonlinear analytical theory, it was found that, at a certain critical angle, an abrupt switching from the self-localized nonlinear "bullet" mode to a propagating quasilinear Slonczewski mode takes place and is accompanied by an upward jump in generated microwave frequency. It was also found that the analytical theory overestimates the magnitude of a critical magnetization angle corresponding to the mode switching and that the magnitude of the frequency jump caused by the mode switching is inversely proportional to the nanocontact radius. Numerical modeling performed in the region of large above-threshold currents, which is not accessible to analytical theory, allowed us to determine the intervals of the bias current variation corresponding to excitation of propagating and self-localized spin-wave modes, and reveal hysteretic and nonhysteretic scenarios of microwave generation with the variation of bias current. C1 [Consolo, G.; Azzerboni, B.] Univ Messina, Dipartimento Fis Mat & Ingn Elettron, I-98166 Messina, Italy. [Lopez-Diaz, L.] Univ Salamanca, Dept Fis Applicada, E-37008 Salamanca, Spain. [Gerhart, G.; Bankowski, E.] USA, TARDEC, Warren, MI 48397 USA. [Tiberkevich, V.; Slavin, A. N.] Oakland Univ, Dept Phys, Rochester, MI 48309 USA. RP Consolo, G (reprint author), Univ Messina, Dipartimento Fis Mat & Ingn Elettron, Salita Sperone 31, I-98166 Messina, Italy. EM consolo@ingegneria.unime.it RI Tiberkevich, Vasil/A-8697-2008; OI Tiberkevich, Vasil/0000-0002-8374-2565; AZZERBONI, Bruno/0000-0001-7642-6540; consolo, giancarlo/0000-0002-6368-8733 NR 24 TC 32 Z9 33 U1 1 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD JUL PY 2008 VL 78 IS 1 AR 014420 DI 10.1103/PhysRevB.78.014420 PG 7 WC Physics, Condensed Matter SC Physics GA 333YR UT WOS:000258190000079 ER PT J AU Glinka, YD Maryenko, D Smet, JH AF Glinka, Y. D. Maryenko, D. Smet, J. H. TI Thickness-tunable terahertz plasma oscillations in a semiconductor slab excited by femtosecond optical pulses SO PHYSICAL REVIEW B LA English DT Article ID FIELD-EFFECT TRANSISTORS; DC-ELECTRIC-FIELD; PHONON OSCILLATIONS; GAAS; GENERATION; RADIATION; WAVES; RELAXATION; EXCITATION; EMISSION AB We report on the observation of terahertz oscillations in an electron-hole plasma optically excited by a femtosecond pulse in the mu m-sized slab of low-temperature-grown-GaAs (LT-GaAs) grown on the GaAs substrate. The frequency of oscillations is shown to be inversely proportional to the slab thickness. It is suggested that the LT-GaAs slab serves as a resonant cavity for traveling plasma waves, which have been generated as a consequence of the shock interaction of photoexcited electron plasma with the GaAs/LT-GaAs interface. The instantaneous diffusion of photoexcited plasma inward the material is driven by the density gradient over the Beer's law distributed carrier population and is evidenced to be a main reason of the shock interaction in the localized plasma. The frequencies of oscillations observed are 3.5 times larger that the inverse electron transit time in the LT-GaAs slab, suggesting the "ballistic" regime for plasma wave propagation to occur. The oscillations have been observed in the photocurrent autocorrelation measurements. The dynamical electric field at the GaAs/LT-GaAs interface arising due to the instantaneous diffusion of photoexcited electrons inward the material was studied through the transient reflectivity change responses, which have been measured simultaneously with photocurrent. C1 [Glinka, Y. D.; Maryenko, D.; Smet, J. H.] Max Planck Inst Festkorperforsch, D-70569 Stuttgart, Germany. RP Glinka, YD (reprint author), USA, Aviat & Missile RDEC, Redstone Arsenal, AL 35809 USA. EM glinkay@uah.edu NR 26 TC 7 Z9 7 U1 1 U2 9 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD JUL PY 2008 VL 78 IS 3 AR 035328 DI 10.1103/PhysRevB.78.035328 PG 10 WC Physics, Condensed Matter SC Physics GA 333YU UT WOS:000258190300104 ER PT J AU Ivanic, J Wallqvist, A Reifman, J AF Ivanic, Joseph Wallqvist, Anders Reifman, Jaques TI Probing the Extent of Randomness in Protein Interaction Networks SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID SELF-ORGANIZED CRITICALITY; SCALE-FREE; SACCHAROMYCES-CEREVISIAE; BIOLOGICAL NETWORKS; METABOLIC NETWORKS; 2-HYBRID ANALYSIS; ESCHERICHIA-COLI; GENE DUPLICATION; DEGREE SEQUENCE; INTERACTION MAP AB Protein-protein interaction (PPI) networks are commonly explored for the identification of distinctive biological traits, such as pathways, modules, and functional motifs. In this respect, understanding the underlying network structure is vital to assess the significance of any discovered features. We recently demonstrated that PPI networks show degree-weighted behavior, whereby the probability of interaction between two proteins is generally proportional to the product of their numbers of interacting partners or degrees. It was surmised that degree-weighted behavior is a characteristic of randomness. We expand upon these findings by developing a random, degree-weighted, network model and show that eight PPI networks determined from single high-throughput (HT) experiments have global and local properties that are consistent with this model. The apparent random connectivity in HT PPI networks is counter-intuitive with respect to their observed degree distributions; however, we resolve this discrepancy by introducing a non-network-based model for the evolution of protein degrees or "binding affinities.'' This mechanism is based on duplication and random mutation, for which the degree distribution converges to a steady state that is identical to one obtained by averaging over the eight HT PPI networks. The results imply that the degrees and connectivities incorporated in HT PPI networks are characteristic of unbiased interactions between proteins that have varying individual binding affinities. These findings corroborate the observation that curated and high-confidence PPI networks are distinct from HT PPI networks and not consistent with a random connectivity. These results provide an avenue to discern indiscriminate organizations in biological networks and suggest caution in the analysis of curated and high-confidence networks. C1 [Ivanic, Joseph; Wallqvist, Anders; Reifman, Jaques] USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. RP Ivanic, J (reprint author), USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU U. S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland; U. S. Army's Network Science FX The authors were supported, in part, by the Military Operational Medicine research program of the U. S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland. This effort was supported by the U. S. Army's Network Science initiative. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U. S. Army or the U. S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 67 TC 10 Z9 10 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-734X J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD JUL PY 2008 VL 4 IS 7 AR e1000114 DI 10.1371/journal.pcbi.1000114 PG 12 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA 360EF UT WOS:000260039300022 PM 18769589 ER PT J AU Blank, S AF Blank, Stephen TI The Putin Succession and Its Implications for Russian Politics SO POST-SOVIET AFFAIRS LA English DT Article AB Has Putin strengthened the Russian state or merely reinforced a particular regime? Russia's condition and recent development are examined in the context of the succession struggles in post-Soviet Russia. The parallels between contemporary Russia and the model of the patrimonial service state in which the state is the tsar's patrimony and he can use it as he sees fit without being accountable to anyone, a concept founded on the notion of power as property and the idea that the king's royal domain is indistinct from the state, are explored with attention paid to intra-elite power struggles, institutional changes leading to the current succession, and the development of state corporations. C1 USA, Strateg Studies Inst, War Coll, Carlisle, PA 17013 USA. RP Blank, S (reprint author), USA, Strateg Studies Inst, War Coll, Carlisle, PA 17013 USA. NR 61 TC 2 Z9 2 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1060-586X EI 1938-2855 J9 POST-SOV AFF JI Post-Sov. Aff. PD JUL-SEP PY 2008 VL 24 IS 3 BP 231 EP 262 DI 10.2747/1060-586X.24.3.231 PG 32 WC Area Studies; Economics; Political Science SC Area Studies; Business & Economics; Government & Law GA 361XB UT WOS:000260159900002 ER PT J AU Smith, KK Gilcreast, D Pierce, K AF Smith, Kimberly K. Gilcreast, Darlene Pierce, Karen TI Evaluation of staff's retention of ACLS and BLS skills SO RESUSCITATION LA English DT Article DE resuscitation; CPR; ACLS; BLS ID CARDIOPULMONARY-RESUSCITATION SKILLS; CARDIAC-ARREST; NURSES; KNOWLEDGE AB Objectives/purpose: To test registered nurses' abilities to retain basic or advanced life support psychomotor skills and theoretical knowledge. Design: A repeated-measures, quasi-experimental, design was used. Methods: Written and performance tests (initial, post-training, and final testing) used scenarios requiring performance of advanced cardiac life support (ACLS) or basic life support (BLS) skills. Final testing was by random assignment to 3, 6, 9, or 12 months. Sample: A convenience sample (n = 133) was used. Instrumentation: American Heart Association 2000 ACLS and BLS evaluation tools were used in a simulated testing environment. Findings: Findings show nurses retain theoretical knowledge but performance skills degrade quickly. ACLS skills degrade faster than BLS skills with 63% passing BLS at 3 months and 58% at 12 months. Only 30% of participants passed ACLS skills at 3 months and 14% at 12 months. These findings are similar to the results of other investigators in over a decade of research. Conclusions: Study results showed a decline in skills retention with nurses unable to perform ACLS and BLS skills to standard for the entire certification period. The need for more frequent refresher training is needed. No format research at this institution indicates skill degradation adversely affected patient outcomes. Further research on ACLS and BLS course content, design, management, and execution is needed. (c) 2008 Elsevier Ireland Ltd. All rights reserved. C1 [Smith, Kimberly K.] USA, Inst Surg Res, Burn Ctr Consultant OTSG, Crit Care Nursing USA,Inst Surg Res, San Antonio, TX 78234 USA. [Gilcreast, Darlene] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78233 USA. [Pierce, Karen] Team ACLS, San Antonio, TX 78234 USA. [Pierce, Karen] BLS, San Antonio, TX 78234 USA. RP Smith, KK (reprint author), USA, Inst Surg Res, Burn Ctr Consultant OTSG, Crit Care Nursing USA,Inst Surg Res, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM kimberty.k.smith@amedd.army.mil NR 15 TC 117 Z9 122 U1 0 U2 7 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD JUL PY 2008 VL 78 IS 1 BP 59 EP 65 DI 10.1016/j.resuscitation.2008.02.007 PG 7 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA 324MP UT WOS:000257523000011 PM 18406037 ER PT J AU Killgore, WDS Kahn-Greene, ET Lipizzi, EL Newman, RA Kamimori, GH Balkin, TJ AF Killgore, William D. S. Kahn-Greene, Ellen T. Lipizzi, Erica L. Newman, Rachel A. Kamimori, Gary H. Balkin, Thomas J. TI Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills SO SLEEP MEDICINE LA English DT Article DE sleep deprivations; emotional intelligence; EQ; constructive thinking; coping; stress ID DECISION-MAKING; PREFRONTAL CORTEX; COGNITIVE PERFORMANCE; UNIVERSITY-STUDENTS; DOSE-RESPONSE; ONE NIGHT; 24 H; CAFFEINE; TASK; RESTRICTION AB Background and purpose: Insufficient sleep can adversely affect a variety of cognitive abilities, ranging from simple alertness to higher-order executive functions. Although the effects of sleep loss on mood and cognition are well documented, there have been no controlled studies examining its effects on perceived emotional intelligence (EQ) and constructive thinking, abilities that require the integration of affect and cognition and are central to adaptive functioning. Patients and methods: Twenty-six healthy volunteers completed the Bar-On Emotional Quotient Inventory (EQi) and the Constructive Thinking Inventory (CTI) at rested baseline and again after 55.5 and 58 h of continuous wakefulness, respectively. Results: Relative to baseline, sleep deprivation was associated with lower scores on Total EQ (decreased global emotional intelligence), Intrapersonal functioning (reduced self-regard, assertiveness, sense of independence, and self-actualization), Interpersonal functioning (reduced empathy toward others and quality of interpersonal relationships), Stress Management skills (reduced impulse control and difficulty with delay of gratification), and Behavioral Coping (reduced positive thinking and action orientation). Esoteric Thinking (greater reliance on formal superstitions and magical thinking processes) was increased. Conclusions: These findings are consistent with the neurobehavioral model suggesting that sleep loss produces temporary changes in cerebral metabolism, cognition, emotion, and behavior consistent with mild prefrontal lobe dysfunction. Published by Elsevier B.V. C1 [Killgore, William D. S.; Kahn-Greene, Ellen T.; Lipizzi, Erica L.; Newman, Rachel A.; Kamimori, Gary H.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM william.killgore@us.army.mil OI Killgore, William/0000-0002-5328-0208 NR 85 TC 102 Z9 104 U1 8 U2 54 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1389-9457 J9 SLEEP MED JI Sleep Med. PD JUL PY 2008 VL 9 IS 5 BP 517 EP 526 DI 10.1016/j.sleep.2007.07.003 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA 330BA UT WOS:000257913100010 PM 17765011 ER PT J AU Zhang, QC Agarwal, A Burka, A Geil, B Scozzie, C AF Zhang, Qingchun (Jon) Agarwal, Anant Burka, Al Geil, Bruce Scozzie, Charles TI 4H-SiC BJTs with current gain of 110 SO SOLID-STATE ELECTRONICS LA English DT Letter DE power BJTs; degradation; current gain; base thickness; silicon carbide; BV(CEO); BVCBO ID BIPOLAR-JUNCTION-TRANSISTORS AB 4H-SiC BJTs with a common emitter current gain of 110 have been demonstrated. The high current gain was attributed to a thin base of 0.25 mu m which reduces the carrier recombination in the base region. The device open base breakdown voltage (BV(CEO)) of 270 V was much less than the open emitter breakdown voltage (BV(CBO)) of 1560 V due to the emitter leakage current multiplication from the high current gain by "transistor action" of BJTs. The device has shown minimal gain degradation after electrical stress at high current density of >200 A/cm(2) up to 25 h. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Zhang, Qingchun (Jon); Agarwal, Anant; Burka, Al] Cree Inc, Res Triangle Pk, NC 27709 USA. [Geil, Bruce; Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. RP Zhang, QC (reprint author), Cree Inc, 3026 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA. EM Jon_Zhang@cree.com NR 15 TC 26 Z9 27 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD JUL PY 2008 VL 52 IS 7 BP 1008 EP 1010 DI 10.1016/j.sse.2008.03.004 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 330WC UT WOS:000257972500003 ER PT J AU Alexander, TA AF Alexander, Troy A. TI Surface-enhanced Raman spectroscopy: A new approach to rapid identification of intact viruses SO SPECTROSCOPY LA English DT Article ID MANAGEMENT; MONKEYPOX; SMALLPOX; SERS AB Surface-enhanced Raman spectroscopy (SERS) has experienced an explosive resurgence in interest lately. Development of reproducible, spatially uniform SERS-active substrates has made this technique an attractive approach for identification of Raman-active compounds and biological materials including toxins, intact viruses, and intact bacterial cells-spores. We have utilized commercial-off-the-shelf (COTS), reproducible, and spatially uniform patterned surfaces as the basis to develop a rapid and accurate methodology for discrimination of Poxviridae-Chordopoxvirinae virions such as smallpox and human monkeypox. To validate this approach, we have studied intact bovine papular stomatitis (BPSV) and pseudocowpox (PCPV) viruses, Poxviridae virions. SERS spectral signature features make it possible to discriminate between these genetically distinct viral species. Further, partial least squares, a full-spectrum calibration method, has been used to develop personal computer-borne algorithms useful for classification of unknown BPSV and PCPV samples based solely upon their SERS spectral signatures. C1 USA, Res Lab, Sensors & Elect Devices Directorate, Opt & Photon Integrat Branch,Radiometr Sensor Dev, Adelphi, MD USA. RP Alexander, TA (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, Opt & Photon Integrat Branch,Radiometr Sensor Dev, Adelphi, MD USA. NR 18 TC 4 Z9 4 U1 1 U2 4 PU ADVANSTAR COMMUNICATIONS PI DULUTH PA 131 W FIRST ST, DULUTH, MN 55802 USA SN 0887-6703 J9 SPECTROSCOPY JI Spectroscopy PD JUL PY 2008 VL 23 IS 7 BP 36 EP + PG 6 WC Spectroscopy SC Spectroscopy GA 325UY UT WOS:000257615000005 ER PT J AU Kuklo, TR Dmitriev, AE Cardoso, MJ Lehman, RA Erickson, M Gill, NW AF Kuklo, Timothy R. Dmitriev, Anton E. Cardoso, Mario J. Lehman, Ronald A., Jr. Erickson, Mark Gill, Norman W. TI Biomechanical contribution of transverse connectors to segmental stability following long segment instrumentation with thoracic pedicle screws SO SPINE LA English DT Article DE thoracic pedicle screw; transverse connectors; construct stability; axial rotation; crosslinks ID MECHANICAL STABILITY; IDIOPATHIC SCOLIOSIS; CROSS-LINKS; FIXATION AB Study Design. An in vitro biomechanical cadaver study of long segment thoracic pedicle screw constructs with transverse connectors (TC). Objective. To determine the resultant degree of motion of the instrumented thoracic spine after segmental pedicle screw instrumentation with and without TC. Summary of Background Data. TC are generally not thought to be necessary with thoracic pedicle screw constructs, yet to date no study has reported the effect of TCs after all pedicle screw long thoracic fusions. Methods. Eight human cadaveric spines were potted and then instrumented from T4-T10 with bilateral 5.5 mm multiaxial titanium (Ti) pedicle screws and 5.5 mm contoured Ti rods. Specimens were tested with a six-degree-offreedom spine stimulator in the intact condition, after instrumentation, after placement of 1 TC ( 3 different locations) and after placement of both TCs. Data were analyzed by loading modality ( axial rotation, flexion-extension, and lateral bending) using one-way analysis of variance with an alpha of 0.05. Paired t tests were used for post hoc analysis with correction for multiple comparisons. Results. There was no difference with the addition of 1 or 2 TCs in terms of flexion-extension or lateral bending when compared to the instrumented condition ( P > 0.05). Biomechanical testing of the long-segment thoracic constructs in axial rotation ( torsion) loading modes generated the most significant findings of this study. After instrumentation with thoracic pedicle screws, T4-T10 full ROM was significantly reduced from the intact condition ( P < 0.05). On average, TPS alone resulted in a 65% decrease in ROM. However, the addition of a transverse connector at 1 of the 3 positions tested yielded another 20% improvement in axial segmental stability as represented by further ROM reduction. These differences were significant from the TPS only group ( no TCs), regardless of the TC position ( P < 0.05). Furthermore, 2 TCs placed at the proximal and distal ends of the construct provided the greatest biomechanical axial stability to the instrumented specimens ( P < 0.05). This was highlighted by an average of 35% ROM reduction from the stability level achieved with the TPS only constructs ( P < 0.05), or an additional 15% improvement in axial stability over a single TC. Conclusion. For long thoracic pedicle screw constructs, the addition of 1 or 2 TCs significantly decreases construct axial rotation, which is the primary plane of motion for the thoracic spinal region. A single TC contributed to a significant reduction of T4-T10 ROM ( an additional 20%) relative to TPS fixation alone ( P < 0.05), while the location of the TC within the construct was irrelevant. A second TC had an additive effect ( an additional 15% reduction) on axial stability. ( P < 0.05) Flexion-extension and lateral bending are not affected. Single TC significantly improves axial rotation stability in long thoracic pedicle screw constructs. Two crosslinks, however, are better than one. C1 [Kuklo, Timothy R.] WA Univ St Louis, Dept Orthopaed Surg, St Louis, MO USA. [Dmitriev, Anton E.] Walter Reed Army Med Ctr, Spine Res Ctr, Washington, DC 20307 USA. [Cardoso, Mario J.] Walter Reed Army Med Ctr, Dept Neurosurg Serv, Washington, DC 20307 USA. [Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Dept Pediat & Adult Spine Surg, Washington, DC 20307 USA. [Erickson, Mark] Childrens Hosp, Dept Orthopaed Surg, Denver, CO 80218 USA. [Gill, Norman W.] Walter Reed Army Med Ctr, Dept Spine Phys Therapy Sect, Washington, DC 20307 USA. RP Kuklo, TR (reprint author), 1 Barnes Jewish Hosp Plaza,Suite 11300 W Pavilion, St Louis, MO 63110 USA. EM kuklot@wustl.edu NR 11 TC 14 Z9 18 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD JUL 1 PY 2008 VL 33 IS 15 BP E482 EP E487 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 322RS UT WOS:000257393600016 PM 18594445 ER PT J AU Reuss, M AF Reuss, Martin TI Seeing like an engineer - Introduction SO TECHNOLOGY AND CULTURE LA English DT Editorial Material C1 [Reuss, Martin] USA, Corps Engineers, Water Resources, Washington, DC USA. NR 15 TC 12 Z9 12 U1 0 U2 1 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0040-165X J9 TECHNOL CULT JI Technol. Cult. PD JUL PY 2008 VL 49 IS 3 BP 531 EP 546 PG 16 WC History & Philosophy Of Science SC History & Philosophy of Science GA 334SW UT WOS:000258242500001 ER PT J AU Smith, DL Brannon, EL AF Smith, David L. Brannon, Ernest L. TI Growth and habitat occupancy of hatchery coho salmon in an engineered stream SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID SPRING CHINOOK SALMON; COLUMBIA RIVER-BASIN; ONCORHYNCHUS-KISUTCH; WASHINGTON STREAMS; TURBULENCE MEASUREMENTS; TERRITORIAL BEHAVIOR; STEELHEAD TROUT; LOW-TEMPERATURE; YAKIMA RIVER; SMOLTIFICATION AB We designed and constructed a natural channel (hereafter, engineered stream; length = 284 m, flow rate = 0.08 m(3)/s) and compared weight, length, and condition factor between hatchery coho salmon Oncorhynchus kisutch (brood years [BYs] 2000 and 2002) reared in the engineered stream and those reared at Dungeness Hatchery, Washington, under similar temperature regimes. In addition, we compared rearing density, egg-to-smolt survival, smolt density, and smolt capacity in the engineered stream with reported reference values for wild coho salmon in rivers. Mean weight and length of fish reared in the engineered stream were 8-32% and 39-154% less, respectively, than those of fish reared in the hatchery. Mean condition factor was 1.6-3.1% greater for fish reared in the engineered stream than for fish reared in the hatchery. Mean monthly growth differed between the engineered stream and hatchery treatment groups; fish in the engineered stream lost weight during the winter, and those in the hatchery gained weight. Rearing density (245%), smolt density (93-209%), egg-to-smolt survival (61-158%), and smolt capacity (219-411%) in the engineered stream were greater than reported reference values for wild coho salmon in natural systems. The BY 2000 return rate was 2.61% for hatchery-reared fish versus 2.55% for fish from the engineered stream. The BY 2002 return was 0.38% for hatchery fish versus 0.12% for fish from the engineered stream. The most important findings of this study are that engineered streams (1) produce smaller fish exhibiting condition factors and smolt-to-adult return rates similar to those of fish produced by hatcheries, (2) have a greater rearing capacity than natural habitat, and (3) may be an important approach for restoring the rearing capacity of rivers. C1 [Smith, David L.; Brannon, Ernest L.] Univ Idaho, Inst Aquaculture Res, Moscow, ID 83844 USA. RP Smith, DL (reprint author), USA, Engineer Res & Dev Ctr, CEERD EP W, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM david.l.smith@erdc.usace.army.mil NR 53 TC 0 Z9 0 U1 1 U2 2 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0002-8487 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD JUL PY 2008 VL 137 IS 4 BP 1108 EP 1119 DI 10.1577/T07-045.1 PG 12 WC Fisheries SC Fisheries GA 333PD UT WOS:000258163500015 ER PT J AU Wagner, SJ Skripchenko, A Salata, J O'Sullivan, AM Cardo, LJ AF Wagner, Stephen J. Skripchenko, Andrey Salata, Jeanne O'Sullivan, Anne Marie Cardo, Lisa J. TI Inactivation of Leishmania donovani infantum and Trypanosoma cruzi in red cell suspensions with thiazole orange SO TRANSFUSION LA English DT Article ID BLOOD-DONORS; VISCERAL LEISHMANIASIS; STORAGE PROPERTIES; LOS-ANGELES; THIOPYRYLIUM; PHOTOINACTIVATION; PHOTOSENSITIZER; ANTIBODY; ASSAY AB BACKGROUND: Methods for pathogen inactivation are currently available in some European countries for treatment of plasma and platelet (PLT) components; no approved method for treatment of red cells (RBCs) or whole blood is ready for implementation. In a previous study, thiazole orange (TO), a dye commonly used to count reticulated RBCs and PLTs, exhibited potent photoactivity against human immunodeficiency virus-1 and several model viruses in RBC suspensions. The aim of this study is to further evaluate the ability of TO to inactivate pathogens by measuring its activity against the protozoa Leishmania donovani infantum and Trypanosoma cruzi. STUDY DESIGN AND METHODS: RBC suspensions were deliberately contaminated with L. donovani infantum promastigotes or T cruzi trypomastigotes and either maintained as an untreated control, incubated with 80 mu mol per L TO in the dark, or treated with TO and light. Control and treated samples were inoculated into medium and subsequently microscopically examined for growth. RESULTS: No growth was observed in samples treated with TO in the presence or absence of light, while matched control samples lacking TO and diluted up to 5 log consistently demonstrated Leishmania or T cruzi growth (n = 3). CONCLUSION: TO inactivated Leishmania or T cruzi to the limit of detection in RBC suspensions without intentional illumination. C1 Amer Red Cross, Jerome H Holland Lab Biomed Sci, Blood Components Dept, Rockville, MD USA. Walter Reed Army Inst Res, Blood Res Dept, Silver Spring, MD USA. RP Wagner, SJ (reprint author), Amer Red Cross, Holland Lab, 15601 Crabbs Branch Way, Rockville, MD USA. EM wagners@usa.redcross.org NR 30 TC 7 Z9 8 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD JUL PY 2008 VL 48 IS 7 BP 1363 EP 1367 DI 10.1111/j.1537-2995.2008.01712.x PG 5 WC Hematology SC Hematology GA 322PB UT WOS:000257386700014 PM 18422841 ER PT J AU Vanasupa, BP Aaberg, RA Sutherland, RS AF Vanasupa, Bill P. Aaberg, Randal A. Sutherland, Ronald S. TI A pure triphasic testicular Wilms tumor of primordial germ cell origin - Reply SO UROLOGY LA English DT Letter C1 [Vanasupa, Bill P.; Sutherland, Ronald S.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Aaberg, Randal A.] Kaiser Permanente, Honolulu, HI USA. RP Vanasupa, BP (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD JUL PY 2008 VL 72 IS 1 BP 233 EP 233 DI 10.1016/j.urology.2007.12.044 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 329QZ UT WOS:000257887000061 ER PT J AU Barillo, DJ AF Barillo, David J. TI Topical antimicrobials in burn wound care: A recent history SO WOUNDS-A COMPENDIUM OF CLINICAL RESEARCH AND PRACTICE LA English DT Article ID SILVER SULFADIAZINE; INFECTED WOUNDS; PSEUDOMONAS; THERAPY; WAR C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Barillo, DJ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM david.barillo@us.army.mil NR 36 TC 5 Z9 5 U1 0 U2 1 PU H M P COMMUNICATIONS PI MALVERN PA 83 GENERAL WARREN BLVD, STE 100, MALVERN, PA 19355 USA SN 1044-7946 EI 1943-2704 J9 WOUNDS JI Wounds-Compend. Clin. Res. Pract. PD JUL PY 2008 VL 20 IS 7 BP 192 EP 198 PG 7 WC Dermatology; Surgery SC Dermatology; Surgery GA 335EC UT WOS:000258272600004 PM 25942608 ER PT J AU Boddu, VM Abburi, K Maloney, SW Damavarapu, R AF Boddu, Veera M. Abburi, Krishnaiah Maloney, Stephen W. Damavarapu, Reddy TI Physicochemical properties of an insensitive munitions compound, N-methyl-4-nitroaniline (MNA) SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE solubility; octanol-water partition coefficient; Henry's law constant; N-methyl-4-nitroaniline ID HENRYS LAW CONSTANTS; WATER; SOLUBILITY; CL-20 AB Accurate information on physicochemical properties of an organic contaminant is essential for predicting its environmental impact and fate. These properties also provide invaluable information for the overall understanding of environmental distribution, biotransformation, and potential treatment processes. In this study the aqueous solubility (S-w), octanol-water partition coefficient (K-ow), and Henry's law constant (K-H) were determined for an insensitive munitions (IM) compound, N-methyl-4-nitroaniline (MNA), at 298.15, 308.15, and 318.15 K. Effect of ionic strength on solubility, using electrolytes such as NaCl and CaCl2, was also studied. The data on the physicochemical parameters were correlated using the standard Van't Hoff equation. All three properties exhibited a linear relationship with reciprocal temperature. The enthalpy and entropy of phase transfer were derived from the experimental data. Published by Elsevier B.V. C1 [Boddu, Veera M.; Abburi, Krishnaiah; Maloney, Stephen W.] USA, Ctr Res Dev & Engn, Environm Proc Branch, Champaign, IL 61822 USA. [Damavarapu, Reddy] USA, Armament Res Dev & Engn Ctr, Energet & Warheads Div, Picatinny Arsenal, NJ 07806 USA. RP Boddu, VM (reprint author), USA, Ctr Res Dev & Engn, Environm Proc Branch, 2902 Newmark Dr, Champaign, IL 61822 USA. EM Veera.Boddu@erdc.usace.army.mil NR 20 TC 7 Z9 7 U1 0 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD JUN 30 PY 2008 VL 155 IS 1-2 BP 288 EP 294 DI 10.1016/j.jhazmat.2007.11.074 PG 7 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 310TH UT WOS:000256552800037 PM 18180104 ER PT J AU Felt, DR Larson, SL Escalon, L AF Felt, D. R. Larson, S. L. Escalon, L. TI An extraction/concentration procedure for analysis of low-level explosives in soils SO TALANTA LA English DT Article DE explosives; extraction; high-performance liquid chromatography; salting-out; soil; training ranges ID SALTING-OUT; DEGRADATION; WATER AB The methods traditionally used for explosives analysis in soil matrices have inherent data quality limitations for low-level samples. The traditional methods employ a soil-dilution extraction of the sample prior to analysis by high performance liquid chromatography with UV absorption detection. Another concern with the traditional analysis is that energetics contamination in environmental samples is often very heterogeneous in nature, usually requiring a large number of samples and multiple testing. The technique presented here addresses these data quality limitations by using a concentrative extraction procedure which produces a small volume of extract from a large soil sample. A concentration factor of 60-fold is achieved in this manner and energetics detection limits for soils are lowered by two orders of magnitude. The larger soil sample size also helps reduce the error associated with sample heterogeneity. The ability to detect explosive-based contaminants at levels of environmental interest enables a more accurate assessment of the transport pathways and treatment options for explosives contamination. (C) 2008 Elsevier B.V. All rights reserved. C1 [Felt, D. R.; Larson, S. L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Escalon, L.] SpecPro Inc, Vicksburg, MS 39180 USA. RP Felt, DR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Deborah.Felt@usace.army.mil NR 21 TC 5 Z9 6 U1 3 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD JUN 30 PY 2008 VL 76 IS 1 BP 21 EP 28 DI 10.1016/j.talanta.2008.01.059 PG 8 WC Chemistry, Analytical SC Chemistry GA 316FI UT WOS:000256934200004 PM 18585234 ER PT J AU Bednar, AJ AF Bednar, Anthony J. TI Comments on "The determination of tungsten, molybdenum, and phosphorus oxyanions by high performance liquid chromatography inductively coupled plasma mass spectrometery" by Bednar et al. - Reply SO TALANTA LA English DT Letter ID NEVADA C1 US Army Corps Engn, ERDC, Vicksburg, MS 39180 USA. RP Bednar, AJ (reprint author), US Army Corps Engn, ERDC, EP-C,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@usace.army.mil NR 3 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD JUN 30 PY 2008 VL 76 IS 1 BP 234 EP 234 DI 10.1016/j.talanta.2008.02.016 PG 1 WC Chemistry, Analytical SC Chemistry GA 316FI UT WOS:000256934200039 ER PT J AU Grenfell, TC Perovich, DK AF Grenfell, Thomas C. Perovich, Donald K. TI Incident spectral irradiance in the Arctic Basin during the summer and fall SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID NONSPHERICAL ICE PARTICLE; SEA-ICE; ABSORPTION-COEFFICIENTS; SURFACE OBSERVATIONS; INDEPENDENT SPHERES; RADIATIVE-TRANSFER; SOLAR IRRADIANCE; STRATUS CLOUDS; ALBEDO; CLIMATE AB Calibrated values of incident spectral irradiance are reported from the Healy Oden Transarctic Experiment during August and September 2005. Spectra were obtained for a wide range of solar zenith angles, cloud conditions, and surface types to provide basic data for regional shortwave radiative energy balance calculations as well as climate model parameterization and validation. Supervised principal component analysis on the spectral continuum showed that three principal components explain over 99% of the variance resulting from darkening across the solar spectrum with increasing cloud cover by volume scattering, from stronger attenuation in the solar infrared relative to visible wavelengths by H2O, and from Rayleigh scattering. Comparison of the observations with the atmospheric radiation model SBDART showed that good agreement was obtained varying only the cloud optical depth. Applying the model, we showed how the surface albedo affects incident spectral irradiance under clear as well as cloudy skies, and we obtained a quantitative estimate of the visual effects of "water sky'' and "ice blink.'' We also determined the spectral albedo of the atmosphere for a dense arctic stratus cloud deck decoupled from the influence of the underlying surface. Incident spectral irradiances were integrated numerically and compared with calibrated pyranometer observations. Agreement was within 5% for cases where the cloud transparency and incident irradiance did not fluctuate strongly over the 10-min pyranometer recording intervals. A new set of values for total albedo for clear versus cloudy conditions at high and low Sun angles is presented for six prominent arctic surface types. C1 [Grenfell, Thomas C.] Univ Washington, Dept Atmospher Sci, Seattle, WA 98195 USA. [Perovich, Donald K.] ERDC CRREL, Hanover, NH 03755 USA. RP Grenfell, TC (reprint author), Univ Washington, Dept Atmospher Sci, Box 351640, Seattle, WA 98195 USA. EM tcg@atmos.washington.edu; donald.k.perovich@usace.army.mil NR 32 TC 15 Z9 15 U1 0 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD JUN 27 PY 2008 VL 113 IS D12 AR D12117 DI 10.1029/2007JD009418 PG 13 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 321MS UT WOS:000257309900002 ER PT J AU Chen, Y Lopez-Sanchez, M Savoy, DN Billadeau, DD Dow, GS Kozikowski, AP AF Chen, Yufeng Lopez-Sanchez, Miriam Savoy, Doris N. Billadeau, Daniel D. Dow, Geoffrey S. Kozikowski, Alan P. TI A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID HDAC INHIBITORS; CRYSTAL-STRUCTURE; TERMINAL ALKYNES; CLASS-I; CYCLOADDITION; HOMOLOG; AZIDES; YEAST; SAHA; ACTIVATION AB The discovery of the rules governing the inhibition of the various HDAC isoforms is likely to be key to identifying improved therapeutics that act as epigenetic modulators of gene transcription. Herein we present results on the modification of the CAP region of a set of triazolylphenyl-based HDACIs, and show that the nature of substitution on the phenyl ring plays a role in their selectivity for HDAC1 versus HDAC6, with low to moderate selectivity (2-51-fold) being achieved. In light of the valuable selectivity and potency that were identified for the triazolylphenyl ligand 6b in the inhibition of HDAC6 (IC(50) = 1.9 nM), this compound represents a valuable research tool and a candidate for further chemical modifications. Lastly, these new HDACIs were studied for both their anticancer and antimalarial activity, which serve to validate the superior activity of the HDACI 10c. C1 [Chen, Yufeng; Kozikowski, Alan P.] Univ Illinois, Dept Med Chem & Pharmacognosy, Drug Discovery Program, Chicago, IL 60612 USA. [Lopez-Sanchez, Miriam; Dow, Geoffrey S.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Savoy, Doris N.; Billadeau, Daniel D.] Mayo Clin Coll Med, Div Oncol Res, Dept Immunol, Rochester, MN 55905 USA. RP Kozikowski, AP (reprint author), Univ Illinois, Dept Med Chem & Pharmacognosy, Drug Discovery Program, 833 S Wood St, Chicago, IL 60612 USA. EM kozikowa@uic.edu NR 51 TC 71 Z9 75 U1 0 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUN 26 PY 2008 VL 51 IS 12 BP 3437 EP 3448 DI 10.1021/jm701606b PG 12 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 316BB UT WOS:000256922800011 PM 18494463 ER PT J AU Gosi, P Khusmith, S Khalambaheti, T Lanar, DE Schaecher, KE Fukuda, MM Miller, SR AF Gosi, Panita Khusmith, Srisin Khalambaheti, Thareerat Lanar, David E. Schaecher, Kurt E. Fukuda, Mark M. Miller, Scott R. TI Polymorphism patterns in Duffy-binding protein among Thai Plasmodium vivax isolates SO MALARIA JOURNAL LA English DT Article ID LIGAND DOMAIN; NUCLEOTIDE SUBSTITUTIONS; DNA POLYMORPHISM; EVOLUTION; RECEPTOR; DIVERSITY; PARASITES; RESIDUES; MALARIA; GENE AB Background: The Duffy-binding protein II of Plasmodium vivax (PvDBPII) has been considered as an attractive target for vaccine-mediated immunity despite a possible highly polymorphic nature. Among seven PvDBP domains, domain II has been shown to exhibit a high rate of nonsynonymous polymorphism, which has been suggested to be a potential immune (antibody binding) evasion mechanism. This study aimed to determine the extent of genetic polymorphisms and positive natural selection at domain II of the PvDBP gene among a sampling of Thai P. vivax isolates. Methods: The PvDBPII gene was PCR amplified and the patterns of polymorphisms were characterized from 30 Thai P. vivax isolates using DNA cloning and sequencing. Phylogenetic analysis of the sequences and positive selection were done using DnaSP ver 4.0 and MEGA ver 4.0 packages. Results: This study demonstrated a high rate of nonsynonymous polymorphism. Using Sal I as the reference strain, a total of 30 point-mutations were observed in the PvDBPII gene among the set of Thai P. vivax isolates, of which 25 nonsynonymous and five synonymous were found. The highest frequency of polymorphism was found in five variant amino acids (residues D384G, R390H, L424I, W437R, I503K) with the variant L424I having the highest frequency. The difference between the rates of nonsynonymous and synonymous mutations estimated by the Nei and Gojobori's method suggested that PvDBPII antigen appears to be under selective pressure. Phylogenetic analysis of PvDBPII Thai P. vivax isolates to others found internationally demonstrated six distinct allele groups. Allele groups 4 and 6 were unique to Thailand. Conclusion: Polymorphisms within PvDBPII indicated that Thai vivax malaria parasites are genetically diverse. Phylogenetic analysis of DNA sequences using the Neighbour-Joining method demonstrated that Thai isolates shared distinct alleles with P. vivax isolates from different geographical areas. The study reported here will be valuable for the development of PvDBPII-based malaria vaccine. C1 [Gosi, Panita; Khusmith, Srisin; Khalambaheti, Thareerat] Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, Bangkok 10400, Thailand. [Gosi, Panita; Schaecher, Kurt E.; Fukuda, Mark M.] Armed Forces Res Inst Med Sci US Army MilitaryCom, Dept Immunol & Med, Bangkok, Thailand. [Lanar, David E.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. RP Khusmith, S (reprint author), Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, 420-6 Rajvithi Rd, Bangkok 10400, Thailand. EM panitag@afrims.org; tmskm@mahidol.ac.th; tmtkl@mahidol.ac.th; david.lanar@us.army.mil; Kurt.Schaecher@afrims.org; Mark.Fukuda@afrims.org; robert.s.miller@amedd.army.mil RI Lanar, David/B-3560-2011 NR 27 TC 24 Z9 24 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 26 PY 2008 VL 7 AR 112 DI 10.1186/1475-2875-7-112 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 325SS UT WOS:000257609200001 PM 18582360 ER PT J AU Lee, SE Eick, A Bloom, MS Brundage, JF AF Lee, Seung-Eun Eick, Angelia Bloom, Michael S. Brundage, John F. TI Influenza immunization and subsequent diagnoses of group A streptococcus-illnesses among US Army trainees, 2002-2006 SO VACCINE LA English DT Article DE influenza; influenza vaccine; group A streptococcus; viral-bacterial interaction ID PENICILLIN-G; SURVEILLANCE; DISEASE; PROPHYLAXIS; PHARYNGITIS; BENZATHINE AB To assess the association between influenza immunization and subsequent diagnosis of group A streptococcus (GAS)-illness in Army recruits during influenza seasons 2002-2006. A case-control study was employed with cases as trainees with outpatient GAS diagnosis (ICD-9-CM codes: 034.0,035,038.0,041.01, 320.2,390-392,482.31) during the influenza season, and controls as trainees with no outpatient GAS diagnosis during the influenza season. Primary exposure was influenza immunization during 1 st September to 30th April of each season. Estimated protective effects of influenza immunization against GAS-illness ranged from 50% to 77%. A strong protective effect was suggested for Army trainee influenza immunization on the diagnosis of GAS-illness. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Lee, Seung-Eun; Eick, Angelia; Bloom, Michael S.; Brundage, John F.] USA, Ctr Hlth Promot & Prevent Med, Armed Forces Hlth Surveillance Ctr Provis, Silver Spring, MD 20910 USA. RP Lee, SE (reprint author), USA, Ctr Hlth Promot & Prevent Med, Armed Forces Hlth Surveillance Ctr Provis, 2900 Linden Lane,Suite 200, Silver Spring, MD 20910 USA. EM seungeun.lee@us.army.mil OI Bloom, Michael/0000-0002-0028-5494 NR 20 TC 10 Z9 11 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 25 PY 2008 VL 26 IS 27-28 BP 3383 EP 3386 DI 10.1016/j.vaccine.2008.04.041 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 330FF UT WOS:000257924500004 PM 18501484 ER PT J AU Golden, JW Josleyn, MD Hooper, JW AF Golden, Joseph W. Josleyn, Matthew D. Hooper, Jay W. TI Targeting the vaccinia virus L1 protein to the cell surface enhances production of neutralizing antibodies SO VACCINE LA English DT Article DE DNA vaccine; orthopoxvirus; neutralizing antibody ID INTRANASAL POXVIRUS CHALLENGE; ACTIVATOR SIGNAL SEQUENCES; DNA VACCINE; SMALLPOX VACCINE; PROTECTIVE IMMUNITY; ENVELOPE PROTEIN; PENETRATION PROTEIN; ENCEPHALITIS-VIRUS; NONHUMAN-PRIMATES; LETHAL MONKEYPOX AB The current live-orthopoxvirus vaccine is associated with minor to serious adverse affects, and is contrainclicated for use in a significant portion of the population. As an alternative vaccine, we have previously shown that a DNA subunit vaccine (4pox) based on four orthopoxvirus immunogens (L1 R, B511, A27L and A33R) can produce protective immunity against lethal orthopoxvirus challenges in mice and nonhuman primates. Because antibodies are critical for protection against secondary orthopoxvirus infections, we are now interested in strategies that will enhance the humoral immune response against vaccine targets. Here, we tested the immunogenicity of an Ll R construct to which a tissue plasminogen activator signal sequence was placed in frame with the full-length LIR gene. The tPA-L1R construct produced a more robust neutralizing antibody response in vaccinated mice when the DNA vaccine was administered by gene-gun as a prime/single boost. When the tPA-L1 R construct was substituted for the unmodified Ll R gene in the 4pox vaccine, given as a prime and single boost, animals were better protected from lethal challenge with vaccinia virus (VACV). These findings indicate that adding a tPA-leader sequence can enhance the immunogenicity of the Ll R gene when given as a DNA vaccine. Furthermore, our results demonstrate that a DNA-based vaccine is capable of establishing protection from lethal orthopoxvirus challenges when administered as a prime and single boost without requiring adjuvant. Published by Elsevier Ltd. C1 [Golden, Joseph W.; Josleyn, Matthew D.; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. RP Hooper, JW (reprint author), USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Ft Detrick, MD 21702 USA. EM jay.hooper@amedd.army.mil OI Hooper, Jay/0000-0002-4475-0415 NR 49 TC 18 Z9 18 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 25 PY 2008 VL 26 IS 27-28 BP 3507 EP 3515 DI 10.1016/j.vaccine.2008.04.017 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 330FF UT WOS:000257924500022 PM 18485547 ER PT J AU Kijak, GH Janini, LM Tovanabutra, S Sanders-Buell, E Arroyo, MA Robb, ML Michael, NL Birx, DL McCutchan, FE AF Kijak, Gustavo H. Janini, Luiz Mario Tovanabutra, Sodsai Sanders-Buell, Eric Arroyo, Miguel Angel Robb, Merlin L. Michael, Nelson L. Birx, Debora L. McCutchan, Francine E. TI Variable contexts and levels of hypermutation in HIV-1 proviral genomes recovered from primary peripheral blood mononuclear cells SO VIROLOGY LA English DT Article DE HIV-1; hypermutation; innate immunity; host restriction; APOBEC3G; APOBEC3F ID HUMAN-IMMUNODEFICIENCY-VIRUS; APOBEC3G GENETIC-VARIANTS; POLYMERASE CHAIN-REACTION; SINGLE-STRANDED-DNA; CD4(+) T-CELLS; REVERSE TRANSCRIPTION; MOLECULAR EPIDEMIOLOGY; GASTROINTESTINAL-TRACT; CYTIDINE DEAMINASE; G->A HYPERMUTATION AB APOBEC-mediated cytidine cleamination of HIV-1 genomes during reverse transcription has been shown to be a potent mechanism of host restriction for HIV-1 infection ex vivo and in vitro. However, this defense system can be overcome by the viral protein Vif. Unlike other mechanisms of host restriction, the APOCEC-Vif interaction leaves an imprint on integrated proviruses in the form of G-A hypermutation. In the current work we systematically studied levels, contexts, and patterns of HIV-1 hypermutation in vivo. The analysis of 24 full-genome HIV-1 sequences retrieved from primary PBMCs, representing infections with several HIV-1 clades, and the inclusion of 7 cognate pairs of hypermutated/non-hypermutated sequences derived from the same patient sample, provided a comprehensive view of the characteristics of APOBEC-mediated restriction in vivo. Levels of hypermutation varied nearly 5-fold among the studied proviruses. GpG motifs were most frequently affected (22/24 proviruses). Levels of hypermutation varied across the genome. The reported "twin peak" pattern of hypermutation was observed in 18/24 hypermutants, but the remainder exhibited singular non-conforming patterns. These data suggest considerable complexity in the interplay of host restriction and viral defense during HIV-1 infection. (c) 2008 Elsevier Inc. All rights reserved. C1 [Kijak, Gustavo H.; Janini, Luiz Mario; Tovanabutra, Sodsai; Sanders-Buell, Eric; Arroyo, Miguel Angel; Robb, Merlin L.; McCutchan, Francine E.] Henry M Jackson Fdn Advancement Mil Med, US Mil HIV Res Program, Rockville, MD 20850 USA. [Janini, Luiz Mario] Univ Fed Sao Paulo, Paulista Sch Med, Div Infect Dis, BR-04039 Sao Paulo, Brazil. [Arroyo, Miguel Angel; Michael, Nelson L.; Birx, Debora L.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. RP Kijak, GH (reprint author), Henry M Jackson Fdn Advancement Mil Med, US Mil HIV Res Program, 1600 E Gude Dr, Rockville, MD 20850 USA. EM gkijak@hivresearch.org; mjanini@pesquisa.epm.br; stovanabutra@hivresearch.org; esanders-buell@hivresearch.org; Miguel.Arroyo@afrims.org; mrobb@hivresearch.org; nmichael@hivresearch.org; emg5@cdc.gov; fmccutchan@hivresearch.org RI Janini, Luiz Mario/E-9700-2012; OI Arroyo, Miguel/0000-0001-7416-8867 NR 67 TC 40 Z9 41 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JUN 20 PY 2008 VL 376 IS 1 BP 101 EP 111 DI 10.1016/j.virol.2008.03.017 PG 11 WC Virology SC Virology GA 309UG UT WOS:000256485100011 PM 18436274 ER PT J AU McKenzie, R Venkatesan, MM Wolf, MK Islam, D Grahek, S Jones, AM Bloom, A Taylor, DN Hale, TL Bourgeois, AL AF McKenzie, Robin Venkatesan, Malabi M. Wolf, Marcia K. Islam, Dilara Grahek, Shannon Jones, Andrea M. Bloom, Arlene Taylor, David N. Hale, Thomas L. Bourgeois, A. Louis TI Safety and immunogenicity of WRSd1, a live attenuated Shigella dysenteriae type 1 vaccine candidate SO VACCINE LA English DT Article DE Shigella; S. dysenteriae; live attenuated vaccine ID ENTEROTOXIGENIC ESCHERICHIA-COLI; SHIGA-BACILLUS DYSENTERY; FLEXNERI 2A; IMMUNE-RESPONSES; CENTRAL-AMERICA; VOLUNTEERS; EPIDEMIC; STRAIN; TOXIN; SHIGELLA-DYSENTERIAE-1 AB Among Shigella serotypes Shigella dysenteriae type 1 produces the most severe disease, including cases of hemolytic-uremic syndrome and pandemic outbreaks. WRSd1 is a live S. dysenteriae 1 strain attenuated by deletion of the virG(icsA) gene, which encodes a protein that mediates intercellular spread and stxA, and stxB, which encode the Shiga toxin. In this Phase I trial five groups of eight subjects ingested escalating doses of WRSd1 ranging from 10(3) to 10(7) CFU. No subject experienced fever or shigellosis, but 20% had diarrhea. Approximately two-thirds of subjects developed an IgA-ASC response to LPS. Days of fecal shedding of the vaccine strain, but not dose ingested, correlated with stronger immune responses. These results suggest that to be effective an attenuated Shigella vaccine must colonize well. (C) 2008 Elsevier Ltd. All rights reserved. C1 [McKenzie, Robin; Grahek, Shannon; Jones, Andrea M.; Bloom, Arlene; Taylor, David N.; Bourgeois, A. Louis] Johns Hopkins Univ, Ctr Immunizat Res, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. [Venkatesan, Malabi M.; Hale, Thomas L.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. [Wolf, Marcia K.] Walter Reed Army Inst Res, Dept Regulatory Affairs, Silver Spring, MD USA. [Islam, Dilara] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP McKenzie, R (reprint author), Johns Hopkins Univ, Ctr Immunizat Res, Johns Hopkins Bloomberg Sch Publ Hlth, 624 N Broadway,Hampton House,Room 203, Baltimore, MD 21205 USA. EM rmckenz@jhmi.edu FU NCRR NIH HHS [M01 RR 00052] NR 29 TC 21 Z9 21 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 19 PY 2008 VL 26 IS 26 BP 3291 EP 3296 DI 10.1016/j.vaccine.2008.03.079 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 326BG UT WOS:000257632300015 PM 18468742 ER PT J AU Metcalfe, GD Shen, HG Wraback, M Hirai, A Wu, F Speck, JS AF Metcalfe, Grace D. Shen, Hongen Wraback, Michael Hirai, Asako Wu, Feng Speck, James S. TI Enhanced terahertz radiation from high stacking fault density nonpolar GaN SO APPLIED PHYSICS LETTERS LA English DT Article ID POLARIZATION AB Terahertz emission from high stacking fault density m-GaN has been observed using ultrafast pulse excitation. The terahertz signal exhibits a 360 degrees periodicity with sample rotation and a polarity flip at 180 degrees, characteristic of real carrier transport in an in-plane electric field parallel to the c axis induced by stacking fault (SF)-terminated internal polarization at wurtzite domain boundaries. The terahertz emission can be enhanced by several times relative to that from a SF-free m-GaN sample, for which the terahertz signal emanates from surface surge currents and diffusion-driven carrier transport normal to the surface and is independent of the c-axis orientation. C1 [Metcalfe, Grace D.; Shen, Hongen; Wraback, Michael] USA, Res Lab, Sensors & Elect Devices Directorate, AMSRD SE EM, Adelphi, MD 20783 USA. [Hirai, Asako; Wu, Feng; Speck, James S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. RP Metcalfe, GD (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, AMSRD SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.metcalfe@us.army.mil RI Speck, James/H-5646-2011; Wu, Feng/D-5641-2015 NR 14 TC 21 Z9 21 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 16 PY 2008 VL 92 IS 24 AR 241106 DI 10.1063/1.2937911 PG 3 WC Physics, Applied SC Physics GA 316FO UT WOS:000256934900006 ER PT J AU Beck, EV Stahlberg, EA Burggraf, LW Blaudeau, JP AF Beck, Eric V. Stahlberg, Eric A. Burggraf, Larry W. Blaudeau, Jean-Philippe TI A graphical unitary group approach-based hybrid density functional theory multireference configuration interaction method SO CHEMICAL PHYSICS LA English DT Article DE density functional theory; configuration interaction; GUGA ID EXCITED-STATES; CHEMISTRY AB A hybrid density functional theory multireference configuration interaction hybrid model (DFT/MRCI) method for computing electronic excitation energies in heavy-element atomic and molecular systems has been developed within a graphical unitary group approach (GUGA) based configuration interaction framework. Implemented in the COLUMBUS suite of programs, the method advances several new capabilities for evaluating systems involving several electronic spin states, relativistic effects and spin-orbit coupling. The method has been evaluated on several types of systems including carbon monoxide, bromine, bromine fluoride, and uranium +4, uranium +5 and uranyl 2+ ions. The method delivers a high level of experimental consistency with absolute accuracies ranging from 11% to 22%. A reduction in relative error ranging from 11% to 42% is observed for the new method when compared with time dependent density functional theory (TDDFT). The new approach provides a significant improvement in computational effort for comparable MRCI calculations with an observed reduction of expansion size by factors up to 64. (c) 2008 Elsevier B.V. All rights reserved. C1 [Beck, Eric V.] Lawrence Livermore Natl Lab, Def Threat Reduct Agcy, Livermore, CA 94551 USA. [Stahlberg, Eric A.] Ohio Supercomp Ctr, Columbus, OH 43212 USA. [Blaudeau, Jean-Philippe] USA, High Performance Technol Inc, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Burggraf, Larry W.] USAF, Dept Engn Phys, Inst Technol, ENP, Wright Patterson AFB, OH 45433 USA. RP Beck, EV (reprint author), Lawrence Livermore Natl Lab, Def Threat Reduct Agcy, L-159,7000 East Ave, Livermore, CA 94551 USA. EM beck27@llnl.gov; eas@osc.edu; larry.burggraf@afit.edu; blaudejp@asc.hpc.mil NR 28 TC 8 Z9 8 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0104 EI 1873-4421 J9 CHEM PHYS JI Chem. Phys. PD JUN 16 PY 2008 VL 349 IS 1-3 BP 158 EP 169 DI 10.1016/j.chemphys.2008.01.018 PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 324SK UT WOS:000257538300018 ER PT J AU Chia, VM Quraishi, SM Graubard, BI Rubertone, MV Erickson, RL Stanczyk, FZ McGlynn, KA AF Chia, Victoria M. Quraishi, Sabah M. Graubard, Barry I. Rubertone, Mark V. Erickson, Ralph L. Stanczyk, Frank Z. McGlynn, Katherine A. TI Insulin-like growth factor 1, insulin-like growth factor-binding protein 3, and testicular germ-cell tumor risk SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE hormones; insulin-like growth factor binding protein 3; insulin-like growth factor I; testicular neoplasms ID GROWTH-FACTOR-I; IGF-BINDING PROTEIN-3; BODY-SIZE; FACTOR BINDING-PROTEIN-3; GESTATIONAL-AGE; FACTOR (IGF)-I; BREAST-CANCER; BIRTH-WEIGHT; BORN SMALL; MEN AB Studies have consistently shown that taller men are at increased risk of testicular germ-cell tumors. Thus, it is plausible that factors associated with height may also influence risk of these tumors. The authors examined associations between testicular germ-cell tumor risk and circulating concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP-3) among 517 cases and 790 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) Study (2002-2005). Odds ratios and 95% confidence intervals were estimated using logistic regression models, adjusting for age, race/ethnicity, height, and body mass index. All tests of significance were two-sided. Overall, there were no associations between IGF-1 or IGFBP-3 concentrations and risk of testicular germ-cell tumors (p > 0.05). However, when cases were separated by histologic type, there was a suggestion of a reduction in seminoma risk associated with the highest concentrations of IGF-1 as compared with the lowest concentrations (odds ratio = 0.66, 95% confidence interval: 0.40, 1.09). Although there were no overall associations with insulin-like growth factor, contrary to expectation, there was a suggestion that IGF-1 concentrations may be inversely associated with risk of seminoma. C1 [Chia, Victoria M.] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Washington, DC 20310 USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Forest Glen, MD USA. [Stanczyk, Frank Z.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. RP Chia, VM (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, Execut Plaza S,Suite 550,6120 Execut Blvd, Rockville, MD 20892 USA. EM chiav@mail.nih.gov FU Intramural NIH HHS NR 35 TC 6 Z9 6 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 15 PY 2008 VL 167 IS 12 BP 1438 EP 1445 DI 10.1093/aje/kwn080 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 313QU UT WOS:000256755900006 PM 18408226 ER PT J AU Foster, JJ Martin, A Meekins, MD Seery, AB Howell, JE AF Foster, Jillian J. Martin, Aleshea Meekins, Melissa D. Seery, Andrea B. Howell, Joshua E. TI Opportunities for professional involvement SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY LA English DT Editorial Material C1 [Foster, Jillian J.] N Mississippi Med Ctr, Tupelo, MS 38801 USA. [Martin, Aleshea] Humana, Lexington, KY 40218 USA. [Meekins, Melissa D.] Rainbow Babies & Childrens Hosp, Cleveland, OH 44106 USA. [Seery, Andrea B.] USA, Dwight D Eisenhower Med Ctr, Ft Gordon, GA 30905 USA. [Howell, Joshua E.] Johns Hopkins Univ Hosp, Dept Pharm, Baltimore, MD 21287 USA. RP Foster, JJ (reprint author), N Mississippi Med Ctr, Tupelo, MS 38801 USA. EM jhowel20@jhmi.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 USA SN 1079-2082 J9 AM J HEALTH-SYST PH JI Am. J. Health-Syst. Pharm. PD JUN 15 PY 2008 VL 65 IS 12 BP 1120 EP 1121 DI 10.2146/ajhp080024 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 314AM UT WOS:000256781100008 PM 18541680 ER PT J AU Gergich, NLS Pfalzer, LA McGarvey, C Springer, B Gerber, LH Soballe, P AF Gergich, Nicole L. Stout Pfalzer, Lucinda A. McGarvey, Charles Springer, Barbara Gerber, Lynn H. Soballe, Peter TI Preoperative assessment enables the early diagnosis and successful treatment of lymphedema SO CANCER LA English DT Article DE breast cancer; lymphedema; early detection; physical therapy; early intervention; compression; optoelectronic volumetry; subclinical lymphedema ID BREAST-CANCER-TREATMENT; QUALITY-OF-LIFE; UPPER EXTREMITY LYMPHEDEMA; SENTINEL NODE BIOPSY; ARM LYMPHEDEMA; POSTMASTECTOMY LYMPHEDEMA; VOLUME MEASUREMENTS; SURGICAL OUTCOMES; PERIPHERAL EDEMA; FOLLOW-UP AB BACKGROUND. The incidence of breast cancer (BC)-related lymphedema (LE) ranges from 7% to 47%. Successful management of LE relies on early diagnosis using sensitive measurement techniques. In the current study, the authors demonstrated the effectiveness of a surveillance program that included preoperative limb volume measurement and interval postoperative follow-up to detect and treat subclinical LE. METHODS. LE was identified in 43 of 196 women who participated in a prospective BC morbidity trial. Limb volume was measured preoperatively and at 3-month intervals after surgery. If an increase >3% in upper limb (UL) volume developed compared with the preoperative volume, then a diagnosis of LE was made, and a compression garment intervention was prescribed for 4 weeks. Upon reduction of LE, garment wear was continued only during strenuous activity, with symptoms of heaviness, or with visible swelling. Women returned to the 3-month interval surveillance pathway. Statistical analysis was a repeated-measores analysis of variance by time and limb (P <= .001) comparing the LE cohort with an age-matched control group. RESULTS. The time to onset of LE averaged 6.9 months postoperatively. The mean (+/- standard deviation) affected limb volume increase was 83 mL (+/- 119 mL; 6.5% +/- 9.9%) at LE onset (P = .005) compared with baseline. After the intervention, a statistically significant mean 48 mL (+/- 103 mL; 4.1% +/- 8.8%) volume decrease was realized (P < .0001). The mean duration of the intervention was 4.4 weeks (+/- 2.9 weeks). Volume reduction was maintained at an average follow-up of 4.8 months (+/- 4.1 months) after the intervention. CONCLUSIONS. A short trial of compression garments effectively treated subclinical LE. C1 [Gergich, Nicole L. Stout] Natl Naval Med Ctr, Breast Canc Dept, Breast Care Ctr, Bethesda, MD 20889 USA. [Pfalzer, Lucinda A.] Univ Michigan, Phys Therapy Dept, Flint, MI 48503 USA. [McGarvey, Charles] NIH, Dept Rehabil Med, Bethesda, MD 20892 USA. [Springer, Barbara] Walter Reed Army Med Ctr, Phys Therapy Dept, Bethesda, MD USA. [Gerber, Lynn H.] George Mason Univ, Coll Hlth & Human Serv, Fairfax, VA 22030 USA. RP Gergich, NLS (reprint author), Natl Naval Med Ctr, Breast Canc Dept, Breast Care Ctr, 8901 Wisconsin Ave,Bldg 10,4th Floor W, Bethesda, MD 20889 USA. EM nicole.stout@med.navy.mil NR 68 TC 119 Z9 120 U1 1 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0008-543X EI 1097-0142 J9 CANCER-AM CANCER SOC JI Cancer PD JUN 15 PY 2008 VL 112 IS 12 BP 2809 EP 2819 DI 10.1002/cncr.23494 PG 11 WC Oncology SC Oncology GA 311DJ UT WOS:000256580200025 ER PT J AU Yun, HC Prakash, V AF Yun, Heather C. Prakash, Vidhya TI Transmission of adenovirus serotype 14 in the health care setting SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 [Yun, Heather C.; Prakash, Vidhya] San Antonio Mil Med Consortium, San Antonio, TX USA. RP Yun, HC (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr,MCHE-MDI, Ft Sam Houston, TX 78234 USA. EM Heather.yun@amedd.army.mil NR 5 TC 3 Z9 3 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 15 PY 2008 VL 46 IS 12 BP 1935 EP 1936 DI 10.1086/588558 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 303MP UT WOS:000256044900031 PM 18540813 ER PT J AU Maves, RC Cachay, ER Young, MA Fierer, J AF Maves, Ryan C. Cachay, Edward R. Young, Maile Ann Fierer, Joshua TI Secondary syphilis with ocular manifestations in older adults SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID SEXUALLY-TRANSMITTED-DISEASES; NEW-YORK-CITY; HIV-INFECTION; PROZONE PHENOMENON; SAN-FRANCISCO; UNITED-STATES; BISEXUAL MEN; RISK; SEX; TRANSMISSION AB We describe 4 patients (age, 150 years) with secondary syphilis. All patients presented with ocular syphilis, and 2 presented with syphilis-negative rapid plasma reagin titers due to a prozone phenomenon. Three male patients reported sildenafil use. The presentation of these patients with ocular syphilis suggests the need for additional clinical studies involving older patients. C1 [Maves, Ryan C.] USA, Med Res Ctr Detachment, Lima, Peru. [Cachay, Edward R.; Young, Maile Ann; Fierer, Joshua] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. [Fierer, Joshua] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA. [Fierer, Joshua] Vet Adm San Diego Healthcare Syst, San Diego, CA USA. RP Maves, RC (reprint author), USA, Med Res Ctr Detachment, Unit 3800, APO, AA 34031 USA. EM Ryan.Maves@med.navy.mil NR 28 TC 9 Z9 10 U1 1 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 15 PY 2008 VL 46 IS 12 BP E142 EP E145 DI 10.1086/588483 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 303MP UT WOS:000256044900038 PM 18462103 ER PT J AU Boyd, SE La Scala, JJ Palmese, GR AF Boyd, Steven E. La Scala, John J. Palmese, Guiseppe R. TI Molecular relaxation behavior of fatty acid-based vinyl ester resins SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE viscoelastic properties; thermal properties; relaxation; fatty acid vinyl esters; styrene replacements/alternatives ID EMPIRICAL DECAY FUNCTION; WILLIAMS-WATTS; POLYMERS AB The experimental characterization of the time-dependent properties of fatty acid-based vinyl ester resins with reduced styrene content and emissions was conducted and compared with that of various commercial vinyl ester (VE) resins. Constant heating rate and isothermal, multifrequency sweep experiments were conducted over a wide temperature range using dynamic mechanical analysis. Storage and loss modulus master-curves were formed using time-temperature superposition (TTSP) and analyzed to quantify the molecular relaxation behavior using accepted techniques and theories. Special attention was focused on determining the effect of reducing styrene weight percent on the derived viscoelastic properties. The fatty acid-based VE resins were found to have similar or slightly inferior thermomechanical properties and a more pronounced viscoelastic response compared with the commercial resins. However, the research definitively demonstrates that the evaluated fatty acid VE resins are a viable replacement to commercial resins in certain applications with concomitant attractive environmental benefits. (c) 2008 Wiley Periodicals, Inc. C1 [Boyd, Steven E.; La Scala, John J.] USA, Res Lab, AMSRD WMRD WM MC, APG, Aberdeen Proving Ground, MD 21005 USA. [Palmese, Guiseppe R.] Drexel Univ, Dept Chem Engn, Philadelphia, PA 19104 USA. RP Boyd, SE (reprint author), USA, Res Lab, AMSRD WMRD WM MC, APG, Aberdeen Proving Ground, MD 21005 USA. EM boyd@vt.edu NR 28 TC 2 Z9 2 U1 1 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD JUN 15 PY 2008 VL 108 IS 6 BP 3495 EP 3506 DI 10.1002/app.27957 PG 12 WC Polymer Science SC Polymer Science GA 293MK UT WOS:000255339200009 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI World War I: The African front SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 15 PY 2008 VL 133 IS 11 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 314QC UT WOS:000256822900162 ER PT J AU Petrov, D Shkuratov, Y Videen, G AF Petrov, Dmitry Shkuratov, Yuriy Videen, Gorden TI Reply to comment on "optimized matrix inversion technique for the T-matrix method" SO OPTICS LETTERS LA English DT Editorial Material ID SCATTERING AB We respond to the Comment on our paper made by Li [Opt. Lett. 33, 1366 (2008)]. Li noted that the approach undertaken in our original paper [Opt. Lett. 32, 1168 (2007)] is similar to that undertaken by Strassen [Numer. Math. 13, 354 (1969)], although the application for which we used this approach had not been considered. (c) 2008 Optical Society of America. C1 [Videen, Gorden] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. [Petrov, Dmitry; Shkuratov, Yuriy] Kharkov Natl Univ, Inst Astron, UA-61022 Kharkov, Ukraine. RP Videen, G (reprint author), USA, Res Lab, AMSRD ARL CI ES, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM petrov@astron.kharkov.ua; gvideen@arl.army.mil NR 7 TC 1 Z9 1 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUN 15 PY 2008 VL 33 IS 12 BP 1367 EP 1367 DI 10.1364/OL.33.001367 PG 1 WC Optics SC Optics GA 323ED UT WOS:000257425900029 ER PT J AU Lehman, RA Lenke, LG Keeler, KA Kim, YJ Buchowski, JM Cheh, G Kuhns, CA Bridwell, KH AF Lehman, Ronald A., Jr. Lenke, Lawrence G. Keeler, Kathryn A. Kim, Yongjung J. Buchowski, Jacob M. Cheh, Gene Kuhns, Craig A. Bridwell, Keith H. TI Operative treatment of adolescent idiopathic scoliosis with posterior pedicle screw-only constructs - Minimum three-year follow-up of one hundred fourteen cases SO SPINE LA English DT Article DE adolescent idiopathic scoliosis; thoracic pedicle screws; pulmonary function ID COTREL-DUBOUSSET INSTRUMENTATION; THORACOSCOPIC SPINE RELEASE; THORACIC SPINE; BIOMECHANICAL ANALYSIS; PULMONARY-FUNCTION; STRAIGHT-FORWARD; FUSION; ANTERIOR; PLACEMENT; FIXATION AB Study Design. Preoperative review of a prospective study, single institution, consecutive series. Objective. To analyze the intermediate-term follow-up of consecutive adolescent idiopathic scoliosis (AIS) patients treated with pedicle screw constructs. Summary of Background Data. There have been no reports of the intermediate-term findings in North America following posterior spinal fusion with the use of pedicle screw-only constructs. Methods. One hundred and fourteen consecutive patients having a minimum 3-year follow-up (mean 4.8 +/- 1.1; range, 3.0-7.3 years) with AIS were evaluated. The average age at surgery was 14.9 +/- 2.2 years. Radiographic measurements included preoperative (Preop), postoperative (PO), 2-year (2 years), and final follow-up (FFU). A chart review evaluated PFTs, Scoliosis Research Society scores, presence of thoracoplasty, Risser sign, Lenke classification, and complications. Results. The most frequent curve pattern was Lenke type 1 (45.6%), followed by type 3 (21.9%). The average main thoracic curve measured 59.2 degrees +/- 12.2 SD Preop, and corrected to 16.8 degrees +/- 9.9 PO (P < 0.0001). Sagittal thoracic alignment (T5-T12) decreased from 25.8 degrees to 15.5 degrees at FFU (P = 0.05). Nash-Moe grading for apical vertebral rotation (AVR) in the proximal thoracic curve decreased from 2.0 Preop to 1.1 at FFU (P < 0.0001), and AVR in the thoracolumbar/lumbar spine decreased from 1.6 Preop to 1.1 at FFU (P < 0.0001). Importantly, the horizontalization of the subjacent disc measured -8.3 degrees Preop which decreased to -0.9 degrees PO (P < 0.001). PFT follow-up averaged 2.4 years with a 7.1% improvement in FVC (P = 0.004) and 8.8% in FEV(1) (P < 0.0001). SRS scores averaged 83.0% at latest follow-up. Age, gender, Risser sign, or complications did not have a significant effect on outcomes. There were 2 cases of adding-on, 3 late onset infections, 1 with a single pseudarthrosis, but no neurologic complications. Conclusion. This is the largest (N = 114), consecutive series of North American patients with AIS treated with pedicle screws having a minimum of 3-year follow-up. The average curve correction was 68% for the main thoracic, 50% for the proximal thoracic, and 66% for the thoracolumbar/lumbar curve at final follow-up. C1 [Lenke, Lawrence G.; Keeler, Kathryn A.; Buchowski, Jacob M.; Bridwell, Keith H.] Washington Univ, Dept Orthopaed Surg, Med Ctr, Sch Med, St Louis, MO 63110 USA. [Lehman, Ronald A., Jr.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Kim, Yongjung J.] Hosp Special Surg, New York, NY 10021 USA. [Kuhns, Craig A.] Univ Missouri, Sch Med, Columbia, MO 65211 USA. RP Lenke, LG (reprint author), Washington Univ, Dept Orthopaed Surg, Med Ctr, Sch Med, 660 S Euclid Ave,Campus Box 8233, St Louis, MO 63110 USA. EM lenkel@wudosis.wustl.edu OI Buchowski, Jacob/0000-0001-8880-8490 NR 47 TC 65 Z9 74 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD JUN 15 PY 2008 VL 33 IS 14 BP 1598 EP 1604 DI 10.1097/BRS.0b013e318178872a PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 314VO UT WOS:000256837500015 PM 18552676 ER PT J AU Butini, S Campiani, G Borriello, M Gemma, S Panico, A Persico, M Catalanotti, B Ros, S Brindisi, M Agnusdei, M Fiorini, I Nacci, V Novellino, E Belinskaya, T Saxena, A Fattorusso, C AF Butini, Stefania Campiani, Giuseppe Borriello, Marianna Gemma, Sandra Panico, Alessandro Persico, Marco Catalanotti, Bruno Ros, Sindu Brindisi, Margherita Agnusdei, Marianna Fiorini, Isabella Nacci, Vito Novellino, Ettore Belinskaya, Tatyana Saxena, Ashima Fattorusso, Caterina TI Exploiting protein fluctuations at the active-site gorge of human cholinesterases: Further optimization of the design strategy to develop extremely potent inhibitors SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID TORPEDO-CALIFORNICA ACETYLCHOLINESTERASE; MOLECULAR-DYNAMICS SIMULATION; BETA-AMYLOID AGGREGATION; ALZHEIMERS-DISEASE; MOUSE ACETYLCHOLINESTERASE; OMEGA-LOOP; ANDROGEN RECEPTOR; LIGAND-BINDING; RECOGNITION SITES; RATIONAL DESIGN AB Protein conformational fluctuations are critical for biological functions, although the relationship between protein motion and function has yet to be fully explored. By a thorough bioinformatics analysis of cholinesterases (ChEs), we identified specific hot spots, responsible for protein fluctuations and functions, and those active-site residues that play a role in modulating the cooperative network among the key substructures. This drew the optimization of our design strategy to discover potent and reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase (hAChE and hBuChE) that selectively interact with specific protein substructures. Accordingly, two tricyclic moieties differently spaced by functionalized linkers were investigated as molecular yardsticks to probe the finest interactions with specific hot spots in the hChE gorge. A number of SAR trends were identified, and the multisite inhibitors 3a and 3d were found to be the most potent inhibitors of hBuChE and hAChE known to date. C1 [Butini, Stefania; Campiani, Giuseppe; Borriello, Marianna; Gemma, Sandra; Panico, Alessandro; Persico, Marco; Catalanotti, Bruno; Ros, Sindu; Brindisi, Margherita; Agnusdei, Marianna; Fiorini, Isabella; Nacci, Vito; Novellino, Ettore; Fattorusso, Caterina] Univ Siena, European Res Ctr Drug Discovery & Dev, NatSynDrugs, I-53100 Siena, Italy. [Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Panico, Alessandro; Ros, Sindu; Brindisi, Margherita; Agnusdei, Marianna; Fiorini, Isabella; Nacci, Vito] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy. [Borriello, Marianna; Persico, Marco; Catalanotti, Bruno; Novellino, Ettore; Fattorusso, Caterina] Univ Naples Federico 2, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy. [Borriello, Marianna; Persico, Marco; Catalanotti, Bruno; Novellino, Ettore; Fattorusso, Caterina] Univ Naples Federico 2, Dipartimento Chim Farmaceut & Tossicol, I-80131 Naples, Italy. [Belinskaya, Tatyana; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Campiani, G (reprint author), Univ Siena, European Res Ctr Drug Discovery & Dev, NatSynDrugs, Via Laterina 8, I-53100 Siena, Italy. EM campiani@unisi.it RI Gemma, Sandra/D-3568-2009; Persico, Marco/L-8448-2014; butini, stefania/D-9954-2015; fattorusso, caterina/F-7113-2015; Catalanotti, Bruno/D-4025-2016 OI Gemma, Sandra/0000-0002-8313-2417; Persico, Marco/0000-0003-0010-0338; fattorusso, caterina/0000-0003-3330-4281; Catalanotti, Bruno/0000-0002-7532-6959 NR 89 TC 44 Z9 44 U1 0 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUN 12 PY 2008 VL 51 IS 11 BP 3154 EP 3170 DI 10.1021/jm701253t PG 17 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 310BV UT WOS:000256504800015 PM 18479118 ER PT J AU McKenna, MH Stump, BW Hayward, C AF McKenna, Mihan H. Stump, Brian W. Hayward, Chris TI Effect of time-varying tropospheric models on near-regional and regional infrasound propagation as constrained by observational data SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article AB The Chulwon Seismo-Acoustic Array (CHNAR) is a regional seismo-acoustic array with co-located seismometers and infrasound microphones on the Korean peninsula. Data from forty-two days over the course of a year between October 1999 and August 2000 were analyzed; 2052 infrasound-only arrivals and 23 seismo-acoustic arrivals were observed over the six week study period. A majority of the signals occur during local working hours, hour 0 to hour 9 UT and appear to be the result of cultural activity located within a 250 km radius. Atmospheric modeling is presented for four sample days during the study period, one in each of November, February, April, and August. Local meteorological data sampled at six hour intervals is needed to accurately model the observed arrivals and this data produced highly temporally variable thermal ducts that propagated infrasound signals within 250 km, matching the temporal variation in the observed arrivals. These ducts change dramatically on the order of hours, and meteorological data from the appropriate sampled time frame was necessary to interpret the observed arrivals. C1 [McKenna, Mihan H.] USA, Struct Engn Branch, Geotech & Struct Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Stump, Brian W.; Hayward, Chris] So Methodist Univ, Dept Geol Sci, Dallas, TX 75275 USA. RP McKenna, MH (reprint author), USA, Struct Engn Branch, Geotech & Struct Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM h.mckenna@usace.army.mil; bstump@smu.edu; chayward@smu.edu NR 29 TC 10 Z9 10 U1 0 U2 3 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD JUN 7 PY 2008 VL 113 IS D11 AR D11111 DI 10.1029/2007JD009130 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 310WK UT WOS:000256561300001 ER PT J AU Alving, CR Rao, M AF Alving, Carl R. Rao, Mangala TI Lipid A and liposomes containing lipid A as antigens and adjuvants SO VACCINE LA English DT Article; Proceedings Paper CT 1st International Symposium on Genetic and Immune Correlates of HIV Infection and Vaccine-Induced Immunity CY JUN 10-13, 2007 CL Budapest, HUNGARY DE lipopolysaccharide; endotoxin; lipid A; liposomes; antibodies to lipids; adjuvants; innate immunity; adaptive immunity; natural antibodies; polyreactive antibodies; HIV-1; neutralizing antibodies ID TOLL-LIKE RECEPTORS; IMMUNODEFICIENCY-VIRUS TYPE-1; RECOGNIZE PHOSPHATIDYL CHOLINE; MONOCLONAL-ANTIBODIES; BACTERIAL LIPOPOLYSACCHARIDES; ANTIPHOSPHOLIPID ANTIBODIES; IMMUNOLOGICAL ADJUVANTS; NATURAL AUTOANTIBODIES; BIOLOGICAL-ACTIVITIES; HIV-ANTIBODIES AB Lipid A derived from Gram-negative bacterial. lipopolysaccharide is a potent adjuvant and antigen. Incorporation of lipid A into liposomes renders the liposomes themselves immunogenic, resulting in generation of specific antibodies that recognize either the individual liposomal lipids, or the unique pattern presented by the combination of lipids. Using liposomes containing lipid A, numerous polyclonal antisera and monoclonal antibodies have been produced against phospholipids, cholesterol, glycosphingolipids, and lipid A. Many of these antibodies have binding characteristics that are apparently similar to natural antibodies that are normally present in all human sera, and also antibodies that arise in response to various infections. Such antibodies probably represent a bridge between innate and adaptive immunity. The possibile utility of liposomes containing lipid A as a constituent of certain types of novel vaccines was suggested by the observation that murine monoclonal antibodies to liposomal. phosphatidytinositol-4-phosphate neutralized primary isotates of two different clades of HIV-1 in a human peripheral. blood mononuctear cell. neutralization assay. Published by Elsevier Ltd. C1 [Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Vaccine Res Program, Div Retrovirol, Dept Adjuvant & Antigen Res, Rockville, MD 20350 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Vaccine Res Program, Div Retrovirol, Dept Adjuvant & Antigen Res, 1600 E Gude Dr, Rockville, MD 20350 USA. EM calving@hivresearch.org NR 99 TC 32 Z9 32 U1 3 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 6 PY 2008 VL 26 IS 24 BP 3036 EP 3045 DI 10.1016/j.vaccine.2007.12.002 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 323WW UT WOS:000257480100010 PM 18226433 ER PT J AU Branco, LM Matschiner, A Fair, JN Goba, A Sampey, DB Ferro, PJ Cashman, KA Schoepp, RJ Tesh, RB Bausch, DG Garry, RF Guttieri, MC AF Branco, Luis M. Matschiner, Alex Fair, Joseph N. Goba, Augustine Sampey, Darryl B. Ferro, Philip J. Cashman, Kathleen A. Schoepp, Randal J. Tesh, Robert B. Bausch, Daniel G. Garry, Robert F. Guttieri, Mary C. TI Bacterial-based systems for expression and purification of recombinant Lassa virus proteins of immunological relevance SO VIROLOGY JOURNAL LA English DT Article ID FUSION PROTEINS; GUINEA-PIGS; FACTOR-XA; FEVER; CLEAVAGE AB Background: There is a significant requirement for the development and acquisition of reagents that will facilitate effective diagnosis, treatment, and prevention of Lassa fever. In this regard, recombinant Lassa virus (LASV) proteins may serve as valuable tools in diverse antiviral applications. Bacterial-based systems were engineered for expression and purification of recombinant LASV nucleoprotein (NP), glycoprotein 1 (GP1), and glycoprotein 2 (GP2). Results: Full-length NP and the ectodomains of GP1 and GP2 were generated as maltose-binding protein (MBP) fusions in the Rosetta strains of Escherichia coli (E. coli) using pMAL-c2x vectors. Average fusion protein yields per liter of culture for MBP-NP, MBP-GP1, and MBP-GP2 were 10 mg, 9 mg, and 9 mg, respectively. Each protein was captured from cell lysates using amylose resin, cleaved with Factor Xa, and purified using size-exclusion chromatography (SEC). Fermentation cultures resulted in average yields per liter of 1.6 mg, 1.5 mg, and 0.7 mg of purified NP, GP1 and GP2, respectively. LASV-specific antibodies in human convalescent sera specifically detected each of the purified recombinant LASV proteins, highlighting their utility in diagnostic applications. In addition, mouse hyperimmune ascitic fluids (MHAF) against a panel of Old and New World arenaviruses demonstrated selective cross reactivity with LASV proteins in Western blot and enzyme-linked immunosorbent assay (ELISA). Conclusion: These results demonstrate the potential for developing broadly reactive immunological assays that employ all three arenaviral proteins individually and in combination. C1 [Fair, Joseph N.; Ferro, Philip J.; Cashman, Kathleen A.; Guttieri, Mary C.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Fair, Joseph N.; Garry, Robert F.] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. [Branco, Luis M.; Matschiner, Alex; Sampey, Darryl B.] BioFactura Inc, Rockville, MD USA. [Fair, Joseph N.; Goba, Augustine; Bausch, Daniel G.] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA. [Schoepp, Randal J.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Goba, Augustine] Kenema Govt Hosp, Lassa Fever Lab, Kenema, Sierra Leone. [Tesh, Robert B.] Univ Texas Galveston, Med Branch, Dept Pathol, Galveston, TX 77555 USA. RP Guttieri, MC (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM lbranco@biofactura.com; amatschiner@biofactura.com; jfair@tulane.edu; augustgoba@yahoo.com; dsampey@biofactura.com; philip.ferro@amedd.army.mil; kathleen.cashman@amedd.army.mil; randal.schoepp@amedd.army.mil; rtesh@utmb.edu; dbausch@tulane.edu; rfgarry@tulane.edu; mary.guttieri@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU NIAID NIH HHS [UC1 AI067188, 1 UC1 AI067188-01, N01AI30027] NR 20 TC 15 Z9 15 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD JUN 6 PY 2008 VL 5 AR 74 DI 10.1186/1743-422X-5-74 PG 14 WC Virology SC Virology GA 319KA UT WOS:000257161300002 PM 18538016 ER PT J AU Cropek, D Kemme, PA Makarova, OV Chen, LX Rajh, T AF Cropek, Donald Kemme, Patricia A. Makarova, Olga V. Chen, Lin X. Rajh, Tijana TI Selective photocatalytic decomposition of nitrobenzene using surface modified TiO2 nanoparticles SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ZERO-VALENT IRON; ELECTRON-PARAMAGNETIC-RESONANCE; ILLUMINATED TITANIUM-DIOXIDE; RAY-ABSORPTION SPECTROSCOPY; MIXED-PHASE TIO2; WASTE-WATER; PHOTOCHEMICAL REDUCTION; K EDGES; DEGRADATION; PHENOL AB Adsorption and photocatalytic degradation of nitrobenzene (NB) in the presence and absence of phenol (Ph) over UV-illuminated arginine-modified TiO2 Colloids have been investigated by infrared absorption, electron paramagnetic resonance spectroscopy, and X-ray absorption spectroscopy. High performance liquid chromatography (HPLC) and gas chromatography/mass spectrometry were used for monitoring degradation conversion rates and byproduct identification. It was found that photodegradation of NB and Ph strongly depends on the nature of the TiO2 surface. Through the use of the HPLC peak area ratio before and after illumination, the photocatalytic decomposition rate of NB and Ph individually using bare TiO2 is nearly identical (1.7 and 1.5, respectively) and occurs via oxidative mechanism. Through the use of arginine-modified TiO2 nanoparticles, a three-fold increase in the NB decomposition rate is observed while no Ph decomposition is observed. Furthermore, the degradation pathway using the arginine-modified photocatalyst is completely altered to a reductive mechanism, providing a more efficient means to degrade nitrocompounds that are already in a highly oxidized state and limiting the number of byproduct. These results indicate that a critical parameter in the photocatalytic decomposition of NB and Ph is their specific adsorption and coupling to the TiO2 surface. Modification of the TiO2 particle surface with chelating agents demonstrates enhanced interaction with the desired target contaminant to impart selectivity to photocatalysis. C1 [Cropek, Donald; Kemme, Patricia A.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. [Makarova, Olga V.; Chen, Lin X.; Rajh, Tijana] Argonne Natl Lab, Div Chem, Argonne, IL 60439 USA. [Makarova, Olga V.; Chen, Lin X.; Rajh, Tijana] Argonne Natl Lab, Ctr Nanoscale Mat, Argonne, IL 60439 USA. RP Cropek, D (reprint author), USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. EM Donald.M.Cropek@usace.army.mil; rajh@anl.gov NR 77 TC 52 Z9 55 U1 6 U2 48 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUN 5 PY 2008 VL 112 IS 22 BP 8311 EP 8318 DI 10.1021/jp712137x PG 8 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 306RI UT WOS:000256265100036 ER PT J AU Polonis, VR Brown, BK Borges, AR Zolla-Pazner, S Dimitrov, DS Zhang, MY Barnett, SW Ruprecht, RM Scarlatti, G Fenyo, EM Montefiori, DC McCutchan, FE Michael, NL AF Polonis, Victoria R. Brown, Bruce K. Borges, Andrew Rosa Zolla-Pazner, Susan Dimitrov, Dimiter S. Zhang, Mei-Yun Barnett, Susan W. Ruprecht, Ruth M. Scarlatti, Gabriella Fenyoe, Eva-Maria Montefiori, David C. McCutchan, Francine E. Michael, Nelson L. TI Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination SO VIROLOGY LA English DT Review DE human immunodeficiency virus type I (HIV-1); antibodies; neutralization assays; pseudovirus; vaccine immune assessment; standardization ID IMMUNODEFICIENCY-VIRUS TYPE-1; MONOCLONAL-ANTIBODIES; ENVELOPE GLYCOPROTEIN; VACCINES; EPITOPES; BINDING; FUSION; PANEL AB In AIDS vaccine development the pendulum has swung towards a renewed emphasis on the potential role for neutralizing antibodies in a successful global vaccine. It is recognized that vaccine-induced antibody performance, as assessed in the available neutralization assays, may well serve as a "gatekeeper" for HIV-1 subunit vaccine prioritization and advancement. As a result, development of a standardized platform for reproducible measurement of neutralizing antibodies has received considerable attention. Here we review current advancements in our knowledge of the performance of different types of antibodies in a traditional primary cell neutralization assay and the newer, more standardized TZM-bl reporter cell line assay. In light of recently revealed differences (see accompanying article) in the results obtained in these two neutralization formats, parallel evaluation with both platforms should be contemplated as an interim solution until a better understanding of immune correlates of protection is achieved. Published by Elsevier Inc. C1 [Polonis, Victoria R.; Michael, Nelson L.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Brown, Bruce K.; Borges, Andrew Rosa; McCutchan, Francine E.] Henry M Jackson Fdn, Rockville, MD USA. [Zolla-Pazner, Susan] NYU, Sch Med, New York, NY USA. [Zolla-Pazner, Susan] VA Hosp, New York, NY USA. [Dimitrov, Dimiter S.; Zhang, Mei-Yun] NCI, US NIH, Frederick, MD 21701 USA. [Barnett, Susan W.] Novartis Vaccines & Diagnost Inc, Emeryville, CA USA. [Ruprecht, Ruth M.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Ruprecht, Ruth M.] Dana Farber Canc Inst, Boston, MA 02115 USA. [Scarlatti, Gabriella] Ist Sci San Raffaele, I-20132 Milan, IT, Italy. [Fenyoe, Eva-Maria] Lund Univ, Lund, Sweden. [Montefiori, David C.] Duke Univ, Durham, NC USA. RP Polonis, VR (reprint author), WRAIR, 13 Taft Court, Rockville, MD 20850 USA. EM vpolonis@hivresearch.org FU Intramural NIH HHS; NCI NIH HHS [N01 CO 12400] NR 21 TC 83 Z9 85 U1 0 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JUN 5 PY 2008 VL 375 IS 2 BP 315 EP 320 DI 10.1016/j.virol.2008.02.007 PG 6 WC Virology SC Virology GA 304JQ UT WOS:000256106200001 PM 18367229 ER PT J AU Brown, BK Wieczorek, L Sanders-Buell, E Borges, AR Robb, ML Birx, DL Michael, NL McCutchan, FE Polonis, VR AF Brown, Bruce K. Wieczorek, Lindsay Sanders-Buell, Eric Borges, Andrew Rosa Robb, Merlin L. Birx, Deborah L. Michael, Nelson L. McCutchan, Francine E. Polonis, Victoria R. TI Cross-clade neutralization patterns among HIV-1 strains from the six major clades of the pandemic evaluated and compared in two different models SO VIROLOGY LA English DT Article DE HIV-1 neutralization; cross-clade; primary isolate; pseudovirus; TZM-bl reporter cells ID IMMUNODEFICIENCY-VIRUS TYPE-1; SUBTYPE-B; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; VACCINE DEVELOPMENT; CHIMERIC VIRUS; INFECTION; ASSAY; TRANSMISSION; SEROTYPES AB A panel of paired primary virus isolates and envelope pseudoviruses from sixty strains representing six HIV-1 clades was tested for neutralization using pooled, clade-specific plasma in two prominently utilized neutralization platforms: a primary isolate assay using peripheral blood mononuclear cells (PBMC) and a pseudovirus assay using a reporter epithelial cell line. Using the PMBC assay, pairing of the antibody pool against homologous clade viruses generated the highest geometric mean neutralizing antibody titer in 4 out of 6 clades tested, and neutralization patterns showed numerous examples of reciprocal cross-recognition between antibody and viruses of specific clade pairs. In the pseudovirus assay, cross-clade neutralization was more limited, with fewer distinct cross-clade relationships evident. The clade C antibody pool was broadly cross-reactive, neutralizing the greatest number of viruses in both assays. These data highlight the importance of the neutralization assay format employed and suggest that clade C envelopes merit further evaluation for the elicitation of broadly neutralizing antibodies. (c) 2008 Published by Elsevier Inc. C1 [Brown, Bruce K.; Wieczorek, Lindsay; Sanders-Buell, Eric; Borges, Andrew Rosa; Robb, Merlin L.; McCutchan, Francine E.] Henry M Jackson Fdn, Rockville, MD USA. [Birx, Deborah L.; Michael, Nelson L.; Polonis, Victoria R.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA. [Birx, Deborah L.] US Ctr Dis Control, Atlanta, GA USA. RP Polonis, VR (reprint author), Walter Reed Army Inst Res, 13 Taft Court,Suite 200, Rockville, MD 20850 USA. EM vpolonis@hivresearch.org NR 58 TC 70 Z9 72 U1 1 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JUN 5 PY 2008 VL 375 IS 2 BP 529 EP 538 DI 10.1016/j.virol.2008.02.022 PG 10 WC Virology SC Virology GA 304JQ UT WOS:000256106200022 PM 18433824 ER PT J AU Maier, RS Schure, MR Gage, JP Seymour, JD AF Maier, Robert S. Schure, Mark R. Gage, Justin P. Seymour, Joseph D. TI Sensitivity of pore-scale dispersion to the construction of random bead packs SO WATER RESOURCES RESEARCH LA English DT Article ID FIELD-GRADIENT NMR; LATTICE-BOLTZMANN; POROUS-MEDIA; FLUID TRANSPORT; MAGNETIC-RESONANCE; FLOW; BEDS; SIMULATION AB Pore-scale simulations of flow and transport offer the possibility of modeling laboratory-scale experiments without averaging the properties of the porous medium. Comparisons between simulation and experiment are complicated, however, by the difficulty of reproducing the exact geometry of the experimental porous medium in a simulation. Flow and dispersion are affected by differences in packing density, random packing variation, inhomogeneities, and confining walls. It is therefore important to understand the magnitude of such effects when comparing simulation and experiment. We quantify the sensitivity of pore-scale simulations of flow and dispersion to variations in packing density, the random packing algorithm, and selective sphere removal for the case of randomly packed spheres. The results allow us to interpret differences in dispersion between pore-scale simulations and NMR spectroscopy measurements in packed cylinders. Dispersion is analyzed in terms of the time-dependent dispersion coefficient and by the propagator function (i.e., the density function of solute mass versus mass propagation distance). The simulation and experimental propagator functions share important qualitative features, and there are no obvious problems such as an incorrect center of mass. However, the simulation underestimates experimental dispersion, and the underestimate is greater than can be explained by possible differences in packing density and random packing between the NMR and simulated sphere packings. An examination of NMR images of the experimental packing reveals regularities in packing structure and raises the possibility that nonrandom ordering could account for the difference in dispersion. C1 [Maier, Robert S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Schure, Mark R.] Rohm & Haas Co, Theoret Separat Sci Lab, Spring House, PA 19477 USA. [Gage, Justin P.; Seymour, Joseph D.] Montana State Univ, Dept Biol & Chem Engn, Bozeman, MT 59717 USA. RP Maier, RS (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM robert.s.maier@usace.army.mil RI Seymour, Joseph/E-8518-2012 OI Seymour, Joseph/0000-0003-4264-5416 NR 30 TC 18 Z9 18 U1 0 U2 6 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD JUN 4 PY 2008 VL 44 IS 6 AR W06S03 DI 10.1029/2006WR005577 PG 12 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 311AA UT WOS:000256571000001 ER PT J AU Perovich, DK Richter-Menge, JA Jones, KF Light, B AF Perovich, Donald K. Richter-Menge, Jacqueline A. Jones, Kathleen F. Light, Bonnie TI Sunlight, water, and ice: Extreme Arctic sea ice melt during the summer of 2007 SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID MASS-BALANCE AB The summer extent of the Arctic sea ice cover, widely recognized as an indicator of climate change, has been declining for the past few decades reaching a record minimum in September 2007. The causes of the dramatic loss have implications for the future trajectory of the Arctic sea ice cover. Ice mass balance observations demonstrate that there was an extraordinarily large amount of melting on the bottom of the ice in the Beaufort Sea in the summer of 2007. Calculations indicate that solar heating of the upper ocean was the primary source of heat for this observed enhanced Beaufort Sea bottom melting. An increase in the open water fraction resulted in a 500% positive anomaly in solar heat input to the upper ocean, triggering an ice-albedo feedback and contributing to the accelerating ice retreat. C1 [Perovich, Donald K.; Richter-Menge, Jacqueline A.; Jones, Kathleen F.] USA, Cold Reg Res & Engn Lab, Ctr Res Dev & Engn, Hanover, NH 03755 USA. [Light, Bonnie] Polar Sci Ctr, Appl Phys Lab, Seattle, WA 98195 USA. RP Perovich, DK (reprint author), USA, Cold Reg Res & Engn Lab, Ctr Res Dev & Engn, 72 Lyme Rd, Hanover, NH 03755 USA. EM donald.k.perovich@erdc.usace.army.mil NR 19 TC 227 Z9 242 U1 10 U2 74 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JUN 3 PY 2008 VL 35 IS 11 AR L11501 DI 10.1029/2008GL034007 PG 4 WC Geosciences, Multidisciplinary SC Geology GA 310VC UT WOS:000256557800004 ER PT J AU Apperson, S Shende, RV Subramanian, S Tappmeyer, D Gangopadhyay, S Chen, Z Gangopadhyay, K Redner, P Nicholich, S Kapoor, D AF Apperson, S. Shende, R. V. Subramanian, S. Tappmeyer, D. Gangopadhyay, S. Chen, Z. Gangopadhyay, K. Redner, P. Nicholich, S. Kapoor, D. TI Generation of fast propagating combustion and shock waves with copper oxide/aluminum nanothermite composites (vol 91, art no 243109, 2008) SO APPLIED PHYSICS LETTERS LA English DT Correction C1 [Apperson, S.; Shende, R. V.; Subramanian, S.; Tappmeyer, D.; Gangopadhyay, S.] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Chen, Z.] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. [Gangopadhyay, K.] Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. [Redner, P.; Nicholich, S.; Kapoor, D.] USA, ARDEC, Picatinny Arsenal, NJ 07896 USA. RP Apperson, S (reprint author), Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. EM sja895@mizzou.edu NR 1 TC 0 Z9 0 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 2 PY 2008 VL 92 IS 22 AR 229903 DI 10.1063/1.2938420 PG 1 WC Physics, Applied SC Physics GA 310KL UT WOS:000256527900118 ER PT J AU Shott, JP McGrath, SM Pau, MG Custers, JHV Ophorst, O Demoitie, MA Dubois, MC Komisar, J Cobb, M Kester, KE Dubois, P Cohen, J Goudsmit, J Heppner, DG Stewart, VA AF Shott, Joseph P. McGrath, Shannon M. Pau, Maria Grazia Custers, Jerome H. V. Ophorst, Olga Demoitie, Marie-Ange Dubois, Marie-Claude Komisar, Jack Cobb, Michelle Kester, Kent E. Dubois, Patrice Cohen, Joe Goudsmit, Jaap Heppner, D. Gray Stewart, V. Ann TI Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-gamma and antibody responses in mice SO VACCINE LA English DT Article DE malaria; adenovirus 5; adenovirus 35; circumsporozoite; AS01B; falciparum ID MALARIA VACCINE RTS,S/AS02A; RANDOMIZED CONTROLLED-TRIAL; RECOMBINANT ADENOVIRUS; T-CELL; NAIVE ADULTS; IMMUNOGENICITY; IMMUNITY; EFFICACY; FORMULATION; INFECTION AB Falciparum malaria vaccine candidates have been developed using recombinant, replication-deficient serotype 5 and 35 adenoviruses (Ad5, Ad35) encoding the Plasmodium falciparum circumsporozoite surface protein (CSP) (Ad5.CS, Ad35.CS) (Crucell Holland BV, Leiden, The Netherlands). To evaluate the immuno-genicity of these constructs, BALB/cJ mice were immunized twice with either Ad5.CS, Ad35.CS, empty Ad5-vector (eAd5), empty Ad35 vector (eAd35), or saline. Another group received the CSP-based RTS,S malaria vaccine formulated in the proprietary Adjuvant System AS01B (GlaxoSmithKIine Biologicals, Rixensart, Belgium). Here we report that Ad5.CS, Ad35.CS, and RTS,S/AS01B, elicited both cellular and serologic CSP antigen-specific responses in mice. These adenoviral vectors induce strong malaria-specific immunity and warrant further evaluation. Published by Elsevier Ltd. C1 [Shott, Joseph P.; McGrath, Shannon M.; Komisar, Jack; Cobb, Michelle; Kester, Kent E.; Heppner, D. Gray; Stewart, V. Ann] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Malaria Vaccine Program, Silver Spring, MD 20910 USA. [Pau, Maria Grazia; Custers, Jerome H. V.; Ophorst, Olga; Goudsmit, Jaap] Crucell Holland BV, Leiden, Netherlands. [Demoitie, Marie-Ange; Dubois, Marie-Claude; Dubois, Patrice; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. RP Heppner, DG (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Malaria Vaccine Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM joseph.Shott@rhsp.org; donald.heppner@us.army.mil; ann.stewart@wrp-ksm.org RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 33 TC 33 Z9 35 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 2 PY 2008 VL 26 IS 23 BP 2818 EP 2823 DI 10.1016/j.vaccine.2008.03.080 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 312CA UT WOS:000256645500004 PM 18455276 ER PT J AU Steers, NJ Alving, CR Rao, M AF Steers, Nicholas J. Alving, Carl R. Rao, Mangala TI Modulation of immunoproteasome subunits by liposomal lipid SO VACCINE LA English DT Article DE immunoproteasomes; liposomal lipid A; dendritic cells; macrophages ID T-CELL RESPONSES; ENCAPSULATED ANTIGENS; DENDRITIC CELLS; IMMUNOLOGICAL ADJUVANTS; PROTEASOME REGULATOR; MALARIA ANTIGEN; PEPTIDE ANTIGEN; IFN-GAMMA; MACROPHAGES; VACCINE AB Liposomes are phospholipid vesicles that have been used as carriers of antigens and adjuvants. Lipid A, the endotoxic moiety of Gram-negative bacterial lipopolysaccharicle is a potent adjuvant and incorporation into liposomes essentially reduces the endotoxic activity of lipid A. In this study, we analyzed the effect of liposomal lipid A [L(LA)] on the MHC class I antigen processing machinery in murine antigen presenting cells (APCs). L(LA) enhanced the surface expression of MHC class I, class II, CD80, and CD86 molecules, induced the secretion of IFN-gamma, IL-12p40, TNF-alpha and IL-10, and caused a shift in the proteasome profile from constitutive to immunoproteasomes as observed by the induction of beta 2i, beta 5i, PA28 alpha, and PA28 beta subunits. L(LA) acts through the production of IFN-gamma as demonstrated with APCs generated from IFN-gamma knockout mice. L(LA) therefore appears to act as an intracellular adjuvant by upregulating the antigen processing machinery, which could result in efficient antigen presentation. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Steers, Nicholas J.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Rockville, MD 20850 USA. RP Rao, M (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, 1600 Gude Dr, Rockville, MD 20850 USA. EM mrao@hivresearch.org NR 51 TC 8 Z9 8 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 2 PY 2008 VL 26 IS 23 BP 2849 EP 2859 DI 10.1016/j.vaccine.2008.03.065 PG 11 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 312CA UT WOS:000256645500008 PM 18455279 ER PT J AU Lyons, A Longfield, J Kuschner, R Straight, T Binn, L Seriwatana, J Reitstetter, R Froh, IB Craft, D McNabb, K Russell, K Metzgar, D Liss, A Sun, X Towle, A Sun, W AF Lyons, Arthur Longfield, Jenice Kuschner, Robert Straight, Timothy Binn, Leonard Seriwatana, Jitvimol Reitstetter, Raven Froh, Irma B. Craft, David McNabb, Kevin Russell, Kevin Metzgar, David Liss, Alan Sun, Xiao Towle, Andrew Sun, Wellington TI A double-blind, placebo-controlled study of the safety and immunogenicity of live, oral type 4 and type 7 adenovirus vaccines in adults SO VACCINE LA English DT Article DE adenovirus; vaccine; live; oral; virus; type 4; type 7 ID ACUTE RESPIRATORY-DISEASE; DIPLOID TISSUE CULTURE; US MILITARY RECRUITS; MULTIPLEX PCR ASSAY; ANTIBODY RESPONSE; NAVAL RECRUITS; SELECTIVE INFECTION; PROTECTIVE EFFICACY; COST-EFFECTIVENESS; LARGE EPIDEMIC AB Adenovirus serotypes 4 (ADV-4) and 7 (ADV-7) are important causes of febrile acute respiratory disease (ARD) in US military recruits. Previously licensed vaccines, which effectively controlled adenovirus-associated ARD, are no longer available. In the Fall of 2004 we conducted this Phase 1 randomized, double-blind, placebo-controlled trial of the live, oral ADV-4 and ADV-7 vaccines made by a new manufacturer to assess their safety and immunogenicity. The adenovirus vaccines were administered orally together in a single dose to thirty subjects. Twenty eight additional subjects received placebo. Subjects were then observed for 8 weeks. The most commonly reported adverse events were nasal congestion (33%), cough (33%), sore throat (27%), headache (20%), abdominal pain (17%), arthralgia (13%), nausea (13%) and diarrhea (13%). None of these rates differed significantly from placebo. The duration of vaccine virus fecal shedding was 7-21 days. Seventy three percent of vaccine recipients seroconverted to ADV-4 (GMT 23.3) while 63% seroconverted to ADV-7 (GMT 51.1) by Day 28. The new ADV-4 and ADV-7 vaccines were safe and induced a good immune response in the study population. Expanded trials for safety and efficacy are in progress. Published by Elsevier Ltd. C1 [Lyons, Arthur; Kuschner, Robert; Straight, Timothy; Binn, Leonard; Seriwatana, Jitvimol; Sun, Wellington] Walter Reed Army Inst Res, Dept Virus Dis, Div Communicable Dis & Immunol, Silver Spring, MD USA. [Longfield, Jenice; Reitstetter, Raven] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Froh, Irma B.; Craft, David] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [McNabb, Kevin] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Russell, Kevin; Metzgar, David] Naval Hlth Res Ctr, Naval Resp Dis Lab, San Diego, CA USA. [Liss, Alan] Dept Hlth & Human Serv, Washington, DC USA. [Sun, Xiao] Merck & Co Inc, Cbards Upper Gwynedd, PA USA. [Towle, Andrew] VaccGen Int LLC, Larchmont, NY USA. RP Lyons, A (reprint author), Walter Reed Army Inst Res, Dept Virus Dis, Div Communicable Dis & Immunol, Silver Spring, MD USA. EM arthur.lyons@na.amedd.army.mil RI Lyons, Arthur/B-8923-2011; OI Reitstetter, Raven/0000-0002-7466-9781 NR 54 TC 42 Z9 44 U1 2 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUN 2 PY 2008 VL 26 IS 23 BP 2890 EP 2898 DI 10.1016/J.vaccine.2008.03.037 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 312CA UT WOS:000256645500012 PM 18448211 ER PT J AU Enewold, L Zhu, K Stojadinovic, A Peoples, GE Devesa, S AF Enewold, L. Zhu, K. Stojadinovic, A. Peoples, G. E. Devesa, S. TI Trends in thyroid cancer incidence by race and ethnicity in the United States SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 41st Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 24-27, 2008 CL Chicago, IL SP Soc Epidemiol Res C1 [Enewold, L.; Zhu, K.; Stojadinovic, A.; Peoples, G. E.; Devesa, S.] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2008 VL 167 IS 11 SU S BP S62 EP S62 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 307HO UT WOS:000256310200248 ER PT J AU Torres, DM Harrison, SA AF Torres, Dawn M. Harrison, Stephen A. TI HCV replication and statin pleotropism: An adjuvant treatment panacea ? SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Editorial Material ID HEPATITIS-C VIRUS; COMBINATION THERAPY; RNA REPLICATION; INFECTION; GERANYLGERANYLATION; INTERFERON; RIBAVIRIN AB With optimal treatment regimens for hepatitis C still under investigation, novel agents that may improve sustained virologic response (SVR) are needed. The targeting of host lipid metabolism, particularly via the cholesterol-lowering 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or statins, represents a novel approach to hepatitis C therapy and has been proven beneficial in vitro. The study in this issue of the Journal is the first prospective trial that shows benefit, albeit modest, of statin therapy in vivo. While limited by heterogeneous patient population and overall small numbers, this study provides hope that use of statins in combination with standard therapy pegylated interferon and ribavirin may improve SVR. C1 [Torres, Dawn M.; Harrison, Stephen A.] Brooke Army Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Gastroenterol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 18 TC 9 Z9 9 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JUN PY 2008 VL 103 IS 6 BP 1390 EP 1392 DI 10.1111/j.1572-0241.2008.01881.x PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 311OY UT WOS:000256610700015 PM 18479495 ER PT J AU Rooks, VJ Eaton, JP Ruess, L Petermann, GW Keck-Wherley, J Pedersen, RC AF Rooks, V. J. Eaton, J. P. Ruess, L. Petermann, G. W. Keck-Wherley, J. Pedersen, R. C. TI Prevalence and evolution of intracranial hemorrhage in asymptomatic term infants SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article; Proceedings Paper CT 44th Annual Meeting of the American-Society-of-Neuroradiology CY APR 29-MAY 05, 2006 CL San Diego, CA SP Amer Soc Neuroradiol ID NONACCIDENTAL HEAD-INJURY; CEREBRAL BRIDGING VEINS; PERMANENT BRAIN-DAMAGE; SUBDURAL-HEMATOMA; EXTERNAL HYDROCEPHALUS; COMPUTED-TOMOGRAPHY; MENTAL-RETARDATION; CHILD-ABUSE; BIRTH; DIAGNOSIS AB BACKGROUND AND PURPOSE: Subdural hemorrhage (SDH) is often associated with infants experiencing nonaccidental injury (NAI). A study of the appearance and natural evolution of these birth-related hemorrhages, particularly SDH, is important in the forensic evaluation of NAI. The purpose of this study was to determine the normal incidence, size, distribution, and natural history of SDH in asymptomatic term neonates as detected by sonography (US) and MR imaging within 72 hours of birth. MATERIALS AND METHODS: Birth history, delivery method, duration of each stage of labor, pharmaceutic augmentation, and complications during delivery as well as postnatal physical examination were recorded. Brain MR imaging and US were performed on 101 asymptomatic term infants at 3-7 days, 2 weeks, 1 month, and 3 months. Clinical follow-up at 24 months was recorded. RESULTS: Forty-six neonates had SDH by MR imaging within 72 hours of delivery. SDH was seen in both vaginal and cesarean deliveries. All neonates were asymptomatic, with normal findings on physical examination, All 46 had supratentorial SDH seen in the posterior cranium. Twenty (43%) also had infratentorial SDH. US detected 11 of the 20 (55%) infratentorial SDHs and no supratentorial SDH, Most SDHs present at birth were <= 3 mm and had resolved by 1 month, and all resolved by 3 months on MR imaging. Most children with SDHs had normal findings on developmental examinations at 24 months. CONCLUSION: SDH in asymptomatic term neonates after delivery is limited in size and location. C1 [Rooks, V. J.] Tripler Army Med Ctr, Dept Radiol, MCHK DR, Honolulu, HI 96859 USA. [Keck-Wherley, J.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Rooks, V. J.; Ruess, L.; Petermann, G. W.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. [Ruess, L.; Pedersen, R. C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Pediat, Bethesda, MD 20814 USA. [Eaton, J. P.] Weed Army Community Hosp, Ft Irwin, CA USA. RP Rooks, VJ (reprint author), Tripler Army Med Ctr, Dept Radiol, MCHK DR, Honolulu, HI 96859 USA. EM veronica.rooks@us.army.mil NR 43 TC 69 Z9 71 U1 1 U2 4 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 USA SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD JUN-JUL PY 2008 VL 29 IS 6 BP 1082 EP 1089 DI 10.3174/ajnr.A1004 PG 8 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 315QI UT WOS:000256894100010 PM 18388219 ER PT J AU Bloom, MS Hu, Z Gaydos, JC Brundage, JF Tobler, SK AF Bloom, Michael S. Hu, Zheng Gaydos, Joel C. Brundage, John F. Tobler, Steven K. TI Incidence rates of pelvic inflammatory disease diagnoses among Army and Navy recruits - Potential impacts of chlamydia screening policies SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID SEXUALLY-TRANSMITTED INFECTIONS; TRACHOMATIS INFECTIONS; ECTOPIC PREGNANCY; UNITED-STATES; US-ARMY; PREVALENCE; MILITARY; GONORRHEA; HOSPITALIZATION; INFERTILITY AB Background: U.S. Navy policy requires Chlamydia trachomatis screening of all women upon entry to recruit training in conjunction with an educational session, and yearly screening thereafter until age 25. Army policy directs only annual screening of asymptomatic women aged <25. Hence, screening of Army recruits may not occur for up to 12 months following accession. Using routinely collected surveillance data, the rates of outpatient pelvic inflammatory disease (PID) following accession into the Army or Navy were compared to assess the potential implications of these policies. Methods: The population at risk comprised active-component women aged <25 who accessioned to either the U.S. Army or Navy between January 1, 2001, and December 31, 2005. Subjects were followed up to 60 months from accession, either until a first outpatient PID diagnosis occurred or they departed from military service. Data were collected from 2001 to 2006 and analyzed in 2007. Multiple Poisson regression was used to assess the effects of potentially important covariates. Time-to-event analysis was employed to characterize risk over time. Results: There were 1276 and 546 incident outpatient diagnoses of PID among 58,088 Army and 33,046 Navy accessions during 93,918 and 65,863 person-years of follow-up, respectively. The crude incident rate was 64% higher in the Army (13.6/1000 person-years) than the Navy (8.3/1000 person-years). Risk for the Army increased soon after accession, followed by a decline, while risk for the Navy remained comparatively uniform. Conclusions: PID rates were higher in the Army than Navy during the first years of active service. A comprehensive study to elucidate the source of this observed difference is warranted. C1 [Bloom, Michael S.; Hu, Zheng; Brundage, John F.; Tobler, Steven K.] USA, Med Surveillance Activ, US Ctr Hlth Promot & Prevent Med, Silver Spring, MD USA. [Gaydos, Joel C.] US Dept Def, Silver Spring, MD USA. RP Bloom, MS (reprint author), SUNY Albany, Sch Publ Hlth, Room 153,1 Univ Pl, Rensselaer, NY 12144 USA. EM mbloom@uamail.albany.edu OI Bloom, Michael/0000-0002-0028-5494 NR 37 TC 6 Z9 7 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JUN PY 2008 VL 34 IS 6 BP 471 EP 477 DI 10.1016/j.amepre.2008.01.032 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 305HS UT WOS:000256169500003 PM 18471582 ER PT J AU Walden, MJ Murphey, MD Vidal, JA AF Walden, Michael J. Murphey, Mark D. Vidal, Jorge A. TI Incidental enchondromas of the knee SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE appendicular musculoskeletal system; biomedical statistics; enchondromas; MRI; radiologic pathologic correlation ID CHONDROID TUMORS; CHONDROSARCOMA; BONE AB OBJECTIVE. The purpose of our study was to determine the prevalence of incidental enchondromas on routine MR knee imaging. MATERIALS AND METHODS. We retrospectively reviewed 449 consecutive routine knee MR examinations for the presence of enchondromas. MRI was considered positive when a focal geographic area of lobular marrow replacement (nonsubchondral) was identified on T1 weighting and high signal intensity was seen on T2 weighting. Patients with enchondromas were further evaluated for demographics; lesion site, size, and relationship to the physeal plate; aggressive imaging features described with chondrosarcoma; concurrent internal derangement; and study indication. RESULTS. The prevalence of incidental enchondromas was 2.9% on routine knee MR examinations. The prevalence was highest in the distal femur (2.0%), followed by the proximal tibia (0.7%) and the proximal fibula (0.2%). The average lesion size was 1.9 x 1.2 x 1.3 cm (57% of lesions were < 1 cm). Most lesions were located in the metaphysis (71%) or diaphysis (21%). Enchondromas were within 1.5 cm of the physeal plate in 72% of cases. No aggressive imaging features to suggest chondrosarcoma were seen. All patients had evidence of internal derangement as the cause of symptoms and the request for imaging. CONCLUSION. Incidental enchondromas can be identified on 2.9% of routine MR knee examinations, most frequently in the distal femur (2.0%). This significant prevalence is much higher than in an autopsy series (0.2%), likely reflecting the increased sensitivity of MRI for detecting small lesions, and is important to recognize to avoid confusion with other pathologic entities. C1 [Murphey, Mark D.; Vidal, Jorge A.] Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. [Walden, Michael J.; Murphey, Mark D.; Vidal, Jorge A.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20306 USA. [Murphey, Mark D.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. RP Murphey, MD (reprint author), Armed Forces Inst Pathol, Dept Radiol Pathol, 6825 16th St NW,Bldg 54, Washington, DC 20306 USA. EM murphey@afip.osd.mil NR 17 TC 20 Z9 23 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUN PY 2008 VL 190 IS 6 BP 1611 EP 1615 DI 10.2214/AJR.07.2796 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 303TV UT WOS:000256064700034 PM 18492914 ER PT J AU Bui-Mansfield, LT O'Brien, SD AF Bui-Mansfield, Liem T. O'Brien, Seth D. TI Signal abnormalities in the quadratus femoris muscle: Tear or impingement? - Reply SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter ID PAIN C1 [Bui-Mansfield, Liem T.; O'Brien, Seth D.] Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Ft Sam Houston, TX 78234 USA. [Bui-Mansfield, Liem T.] Wake Forest Univ, Winston Salem, NC 27109 USA. [Bui-Mansfield, Liem T.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, Ft Sam Houston, TX 78234 USA. NR 7 TC 3 Z9 4 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUN PY 2008 VL 190 IS 6 BP W380 EP W381 DI 10.2214/AJR.07.3705 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 303TV UT WOS:000256064700063 ER PT J AU Facchinelli, L Koenraadt, CJM Fanello, C Kijchalao, U Valerio, L Jones, JW Scott, TW della Torre, A AF Facchinelli, Luca Koenraadt, Constantianus J. M. Fanello, Caterina Kijchalao, Udom Valerio, Laura Jones, James W. Scott, Thomas W. della Torre, Alessandra TI Evaluation of a sticky trap for collecting Aedes (Stegomyia) adults in a dengue-endemic area in Thailand SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PRIMARY-SCHOOL CHILDREN; AEGYPTI DIPTERA; KAMPHAENG-PHET; PUERTO-RICO; CULICIDAE; POPULATIONS; ALBOPICTUS; MOSQUITOS; PATTERNS AB Development of new operational techniques for collection and monitoring of adult Stegomyia mosquitoes is considered a pressing need for surveillance and prevention of arboviruses. Here we report the results from a trial carried out in 2 dengue-endemic villages in Thailand to compare the ability to collect Aedes adults of a sticky trap versus a CDC backpack aspirator, which has been used routinely at the study area for entomological/epidemiological surveys. Our comparison was based on a comparable sampling effort required to carry out collections with 2 approaches. Over 19,000 specimens were collected, similar to 90% of which were Culex spp. Sticky traps collected significantly more Aedes aegypti and Aedes albopictus females than did backpack aspirators when located outdoors. The percentage of positive sticky-trap catches was double for Ae. aegypti and almost 20 times higher for Ae. albopictus. Operational benefits of the sticky trap are discussed within the context of the results obtained. C1 Univ Roma La Sapienza, Dept Publ Hlth Sci, Parasitol Unit, Rome, Italy. Cornell Univ, Dept Entomol, Ithaca, NY 14853 USA. London Sch Hyg & Trop Med, London WC1, England. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. RP della Torre, A (reprint author), Univ Roma La Sapienza, Sez Parassitol, Dipartimento Sci Sanita Pubbl, Piazzale Aldo Moro 5, I-00185 Rome, Italy. EM ale.dellatorre@uniroma1.it NR 24 TC 19 Z9 20 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2008 VL 78 IS 6 BP 904 EP 909 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 310BS UT WOS:000256504500012 PM 18541767 ER PT J AU Clark, BM Murray, CK Horvath, LL Deye, GA Rasnake, MS Longfield, RN AF Clark, Brychan M. Murray, Clinton K. Horvath, Lynn L. Deye, Gregory A. Rasnake, Mark S. Longfield, Robert N. TI Case-control study of armadillo contact and Hansen's disease SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LEPROMATOUS LEPROSY; MYCOBACTERIUM-LEPRAE; 9-BANDED ARMADILLO; UNITED-STATES; EXPOSURE; TRANSMISSION; HANDLERS; TEXAS; MICE AB Hansen's disease (HD) continues to have worldwide impact despite efforts to eradicate the disease. Although a definitive transmission mode has not been identified, data supports an association between HD and contact with the nine-banded armadillo. We conducted a case-control study of 28 HD patients to determine if there is an association between armadillo exposure and HD. There was no association between HD and place of birth or having hunted, consumed, or had direct or indirect contact with deer, birds, or squirrels. Univariate analysis showed that residence in Mexico (P = 0.001), hunting rabbits (P = 0.04), cleaning rabbits (P < 0.001), and armadillo exposure from hunting (P = 0.005), cleaning (P = 0.004), consuming (P = 0.002) them, or having direct armadillo contact (P = 0.017) were associated with HD. Multivariate analysis showed that eating armadillos (P = 0.039, odds ratio [OR] = 3.65, 95% confidence interval [CI] = 1.07-12.4), cleaning rabbits (P = 0.018, OR = 4.08, 95% CI = 1.27-13.1), and having lived in Mexico (P = 0.006, OR = 24.9, 95% CI = 2.52-245) were associated with HD. C1 Wilford Hall USAF Med Ctr, Dept Infect Dis, Lackland AFB, TX 78236 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78216 USA. USAF, Off Surgeon Gen, Med Modernizat Directorate, Falls Church, VA USA. Univ Tennessee, Grad Sch Med, Dept Med, Knoxville, TN USA. Univ Texas Tyler, Med Specialty Serv, San Antonio, TX USA. Texas Ctr Infect Dis, San Antonio, TX USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78216 USA. EM Clinton.murray@amedd.army.mil NR 26 TC 16 Z9 18 U1 1 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2008 VL 78 IS 6 BP 962 EP 967 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 310BS UT WOS:000256504500022 PM 18541777 ER PT J AU Huitron, S Bonvicino, A Fadare, O AF Huitron, Sonny Bonvicino, Amanda Fadare, Oluwole TI Patients with negative cervical biopsies after papanicolaou test interpretations of "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion": comparative longitudinal follow-up SO ANNALS OF DIAGNOSTIC PATHOLOGY LA English DT Article DE cervical biopsy; Papanicolaou test; squamous intraepithelial lesion; ASC-H ID UNDETERMINED SIGNIFICANCE; RANDOMIZED-TRIAL; ASC-H; CYTOLOGY INTERPRETATIONS; MANAGEMENT; PARTICIPANTS; RULE; LSIL AB Approximately half of women with a Papanicolaou (pap) test interpretation of "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" (ASC-H) will have less than a high-grade dysplasia, diagnosed on their follow-up cervical biopsy sample. Herein, we compared the follow-up findings in a group of women with a negative cervical biopsy after a pap test interpretation of ASC-H (study group) with those of a randomly selected control group of women whose pap tests were interpreted as "negative for intraepithelial lesion or malignancy" during the same period. The diagnoses in every follow-up sample in the control and study groups were tabulated. Patients with previous ASC-H or high-grade squamous intraepithelial lesion interpretations, and/or high-grade cervical intraepithelial neoplasia (CIN) diagnoses, were excluded. Both groups were then statistically compared regarding the diagnostic frequencies of each of the Bethesda 2001 categories and CIN grades. Of the 122 patients with ASC-H interpretations and documented histologic follow-up, the first follow-up biopsy was negative for dysplasia in 20 (16.4%). Seventy-six follow-up samples (70 pap tests, 6 biopsies) were obtained from these 20 patients. In the control group of 262 women with pap tests interpreted as "negative for intraepithelial lesion or malignancy," 641 follow-up samples (629 pap tests, 12 biopsies) were obtained. Patients in the study group were significantly more likely than their control group counterparts to have a follow-up (1) cytologic and/or histologic abnormality (23/76 vs 76/641, respectively; P=.00006), (2) "atypical squamous cells of undetermined significance" (ASC-US) interpretation (13/76 vs 43/641; P=.005), and (3) CIN grade 1 diagnosis (4/76 vs 10/641; P=.05). Approaching statistical significance was the comparatively increased frequency of CIN grade 2 to 3 diagnoses in the study group (2/76 vs 2/641; P=.058). If the analysis is restricted to I follow-up sample (the most severe) per patient, patients in the study group were still more likely than those in the control group to have a follow-up cytologic and/or histologic abnormality (12/20 vs 40/262; P=.0002), ASC-US interpretation (6/20 vs 22/262; P=.008), and follow-up CIN grade 2 to 3 diagnosis (2/20 vs 2/262; P=.03). It is concluded that patients whose cervical biopsies are devoid of dysplasia after an ASC-H interpretation still require close surveillance and follow-up because their risk of being diagnosed with follow-up cervical abnormalities is significantly above baseline. (C) 2008 Elsevier Inc. All rights reserved. C1 [Huitron, Sonny; Bonvicino, Amanda; Fadare, Oluwole] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX 78236 USA. [Huitron, Sonny; Bonvicino, Amanda] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Huitron, Sonny; Bonvicino, Amanda] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, San Antonio, TX 78236 USA. [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. RP Fadare, O (reprint author), Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX 78236 USA. EM oluwolefadare@yahoo.com NR 23 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1092-9134 J9 ANN DIAGN PATHOL JI Ann. Diagn. Pathol. PD JUN PY 2008 VL 12 IS 3 BP 187 EP 190 DI 10.1016/j.anndiagpath.2007.09.001 PG 4 WC Pathology SC Pathology GA 308KZ UT WOS:000256390200005 PM 18486894 ER PT J AU Majka, DS Deane, KD Parrish, LA Lazar, AA Baron, AE Walker, CW Rubertone, MV Gilliland, WR Norris, JM Holers, VM AF Majka, D. S. Deane, K. D. Parrish, L. A. Lazar, A. A. Baron, A. E. Walker, C. W. Rubertone, M. V. Gilliland, W. R. Norris, J. M. Holers, V. M. TI Duration of preclinical rheumatoid arthritis-related autoantibody positivity increases in subjects with older age at time of disease diagnosis SO ANNALS OF THE RHEUMATIC DISEASES LA English DT Article ID CYCLIC CITRULLINATED PEPTIDE; ANTIBODIES; PREDICT; MANIFESTATIONS; POPULATION; PREVALENCE; PRECEDE; INDIANS; ONSET AB Objectives: To investigate factors that may influence the prevalence and timing of appearance of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies during the preclinical phase of rheumatoid arthritis (RA) development. Methods: 243 serial prediagnosis serum samples from 83 subjects with RA were examined for the presence of RF and anti-CCP antibodies. Results: Of the 83 cases, 47 (57%) and 51 (61%) subjects had at least one prediagnosis sample positive for RF or anti-CCP, respectively. Gender and race were not significantly associated with the prevalence or timing of preclinical antibody appearance. Preclinical anti-CCP positivity was strongly associated with the development of erosive RA (odds ratio=4.64; 95% confidence interval 1.71 to 12.63; p<0.01), but RF was not (p=0.60). Additionally, as age at the time of diagnosis of RA increased the duration of prediagnosis antibody positivity for RF and anti-CCP increased, with the longest duration of preclinical antibody positivity seen in patients diagnosed with RA over the age of 40. In no subjects did symptom onset precede the appearance of RF or anti-CCP antibodies. Conclusions: The period of time that RF and anti-CCP are present before diagnosis lengthens as the age at the time of diagnosis of RA increases. This finding suggests that factors such as genetic risk or environmental exposure influencing the temporal relationship between the development of RA-related autoantibodies and clinically apparent disease onset may differ with age. C1 [Majka, D. S.] Northwestern Univ, Feinberg Sch Med, Div Rheumatol, Chicago, IL 60611 USA. [Deane, K. D.; Parrish, L. A.; Holers, V. M.] Univ Colorado, Div Rheumatol, Denver, CO 80202 USA. [Deane, K. D.; Parrish, L. A.; Lazar, A. A.; Baron, A. E.; Norris, J. M.; Holers, V. M.] Univ Colorado, Hlth Sci Ctr, Denver, CO 80202 USA. [Lazar, A. A.; Baron, A. E.; Norris, J. M.] Univ Colorado, Dept Prevent Med & Biometr, Denver, CO 80202 USA. [Walker, C. W.; Gilliland, W. R.] Walter Reed Army Med Ctr, Dept Med, Rheumatol Sect, Washington, DC 20307 USA. [Rubertone, M. V.] USA, Ctr Hlth Promot & Prevent Med, Washington, DC 20310 USA. RP Holers, VM (reprint author), Univ Colorado, Div Rheumatol, 1775 N Ursula St,B-115, Aurora, CO 80045 USA. EM Michael.Holers@uchsc.edu FU NCRR NIH HHS [K12 RR017707]; NIAID NIH HHS [K23 AI064397, K23 AI064397-01A2, R21 AI061479, R21 AI061479-01, R21 AI061479-02, R21 AI61479]; NIAMS NIH HHS [T32 AR07534, K23 AR051461, K23 AR051461-01, K23 AR051461-02, K23 AR051461-03, K23 AR051461-04, K23 AR051461-05, T32 AR007534, T32 AR007534-16, T32 AR007534-18] NR 30 TC 73 Z9 74 U1 0 U2 2 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0003-4967 J9 ANN RHEUM DIS JI Ann. Rheum. Dis. PD JUN PY 2008 VL 67 IS 6 BP 801 EP 807 DI 10.1136/ard.2007.076679 PG 7 WC Rheumatology SC Rheumatology GA 299SD UT WOS:000255774400012 PM 17974596 ER PT J AU Tavaf-Motamen, H Bannister, SP Corcoran, PC Stewart, RW Mulligan, CR DeVries, WC AF Tavaf-Motamen, Houman Bannister, Sean P. Corcoran, Philip C. Stewart, Robert W. Mulligan, Charles R. DeVries, William C. TI Repair of anomalous origin of right coronary artery from the left sinus of Valsalva SO ANNALS OF THORACIC SURGERY LA English DT Editorial Material AB Anomalous origin of the right coronary artery from the left sinus of Valsalva is a rare congenital anomaly but a relatively frequent cause of sudden death in the young. The medical records of 4 consecutive patients with this anomaly were retrospectively reviewed. The first 2 patients underwent coronary artery bypass and had early graft failure. The next 2 patients underwent coronary reimplantation and unroofing and have done well. This limited series suggests that bypass procedures used to treat anomalous origin of the right coronary artery from the left sinus of Valsalva are prone to early graft failure. C1 [Tavaf-Motamen, Houman; Bannister, Sean P.; Corcoran, Philip C.; Stewart, Robert W.; Mulligan, Charles R.; DeVries, William C.] Walter Reed Army Med Ctr, Div Cardiothorac Surg, Washington, DC 20303 USA. RP Tavaf-Motamen, H (reprint author), Walter Reed Army Med Ctr, Div Cardiothorac Surg, 6900 Georgia Ave, Washington, DC 20303 USA. EM houman.tavaf-motamen@na.amedd.army.mil NR 5 TC 16 Z9 16 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD JUN PY 2008 VL 85 IS 6 BP 2135 EP 2136 DI 10.1016/j.athoracsur.2007.07.006 PG 3 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA 303PH UT WOS:000256052200052 PM 18498845 ER PT J AU Keller, SD AF Keller, S. D. TI Coplanar waveguide slot-coupled K-a-band patch antenna for integration with wafer-scale beam-steering MEMS control board SO APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL LA English DT Article DE coplanar waveguide; patch antenna; wafer-scale; MEMS ID SUBSTRATE AB A coplanar waveguide (CPW) slot-coupled K-a-band patch antenna is designed, constructed and tested for subsequent integration with a wafer-scale MEMS-switched antenna array beam-steering control board. The antenna is designed for fabrication on a high resistivity silicon (BRS) wafer (epsilon(r) approximate to 11.8) for operation with 25-30 GHz satellite communication systems. A simulated 10 dB return loss bandwidth of 2.96 GHz (9.8 %) is achieved with a 4.6 dB peak gain and 110 degrees half-power beamwidth (HPBW). A scaled prototype at 6 GHz is constructed on RT/Duroid 6010 substrate (epsilon(r) approximate to 10.2) and yields a measured bandwidth of 360 MHz (6.0%) and a peak gain of 4 dB. A CPW feedline / slot misaligrunent sensitivity test is conducted through simulations to investigate the effects that fabrication errors may have on antenna performance during wafer-scale integration of the patch antenna onto the HRS substrate. Simulation results show that slot misalignment less than 200-400 tan should only minimally affect antenna performance, with the most significant degradation being a 2.5 - 4.0 % drop in antenna bandwidth. The successful design of this patch antenna demonstrates a compact, efficient method for integration of a CPW slot-coupled K-a-band patch antenna onto a wafer-scale MEMS control board without the need for additional substrate layers or feedline interconnects, total system weight and fabrication complexity. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Keller, SD (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM steven.keller4@arl.army.mil NR 15 TC 1 Z9 1 U1 0 U2 2 PU APPLIED COMPUTATIONAL ELECTROMAGNETICS SOC PI UNIVERSITY PA UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA SN 1054-4887 J9 APPL COMPUT ELECTROM JI Appl. Comput. Electromagn. Soc. J. PD JUN PY 2008 VL 23 IS 2 BP 177 EP 183 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 319FK UT WOS:000257149300010 ER PT J AU Smith, CB Anderson, JE Massaro, RD Tatineni, B Kam, KC Tepper, GC AF Smith, Clint B. Anderson, John E. Massaro, Richard D. Tatineni, Balaji Kam, Kinson C. Tepper, Gary C. TI Fluorescence resonance energy transfer based MCM-EDTA-Tb3+-MES sensor SO APPLIED SPECTROSCOPY LA English DT Article DE fluorescence resonance energy transfer; FRET; surface imprinted polymeric sensors; SIP; methyl salicylate; MCM silica; Tb3+; nerve gas surrogate detection ID MESOPOROUS MATERIAL; METHYL SALICYLATE; PROTON-TRANSFER; METAL-IONS; SILICA; WATER; NANOPARTICLES; RECOGNITION; BIOSENSORS; PESTICIDE AB An in situ mesopourous surface imprinted polymeric (SIP) sensor was synthesized for a highly sensitive, selective, and kinetically faster detection of the high-vapor-pressure nerve gas surrogate methyl salicylate (MES). Visual detection occurred on the filtrate thin films at 25 pM. Other nerve gas surrogates, TP, DMP, DMMP, PMP, and 1,4-thioxane, were tested and showed a decrease in sensitivity compared to MES. In addition, 2,6-dipicolinic acid (DPA), a biological indicator, was also investigated and showed a decrease in sensitivity compared to MES. Finally, the detection plateau was reached at 40 s and at 1.5 X 10(-4) M from pH 6-11. C1 [Smith, Clint B.; Anderson, John E.; Massaro, Richard D.] USA, Engn Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA 22315 USA. [Tatineni, Balaji] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. [Kam, Kinson C.] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA. [Tepper, Gary C.] Sentor Technol Inc, Glen Allen, VA 23060 USA. RP Smith, CB (reprint author), USA, Engn Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA 22315 USA. EM clint.b.smith@erdc.usace.army.mil NR 32 TC 2 Z9 2 U1 0 U2 14 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 EI 1943-3530 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUN PY 2008 VL 62 IS 6 BP 604 EP 610 DI 10.1366/000370208784658101 PG 7 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 315IX UT WOS:000256873200008 PM 18559146 ER PT J AU Genovese, RF Newman, DB AF Genovese, Raymond F. Newman, Donald B. TI Understanding artemisinin-induced brainstem neurotoxicity SO ARCHIVES OF TOXICOLOGY LA English DT Article DE artemisinin; arteether; artemether; artesunate; neurotoxicity; brainstem; antimalarial ID CONTROL AUDITORY EVALUATION; PRECEREBELLAR NUCLEI; FALCIPARUM-MALARIA; ANTIMALARIAL-DRUGS; NEURAL TOXICITY; MACACA-MULATTA; ARTELINIC ACID; ARTEETHER; RATS; ARTEMETHER AB Artemisinins are fast-acting and highly efficacious antimalarials. There has been a rapid increase in their use in response to increasing drug resistance and further increases in their use are anticipated as they continue to replace existing therapies. In laboratory studies, artemisinins can produce relatively specific brainstem neurotoxicity. Select nuclei in the medulla, pons and mesencephalon are usually found to be most vulnerable. Species-specific differences in the vulnerability of nuclei may also exist. While not yet completely understood, occurrence of the lesion seems to be dependent upon a sustained, rather than peak, level of circulating drug or metabolite. With daily administrations, the onset of signs of brainstem neurotoxicity frequently develops abruptly and sometimes is observable only at the end of, or after, a regimen of administration. Behavioral correlates of brainstem neurotoxicity in laboratory animals include ataxic symptoms such as tremor, gait impairment and balance disturbance. Symptoms may also include auditory impairment. Screening and diagnostic procedures to guard against artemisinin-induced brainstem neurotoxicity in humans need to be based on the available, albeit limited, data from laboratory studies. Substantial and fundamental gaps in our understanding of artemisinin brainstem neurotoxicity exist including the mode of action of neurotoxicity and the specific conditions under which it occurs. Further, the possibility of increased vulnerability from age-related factors, drug interactions and cumulative administration regimens has not yet been investigated. Substantial progress addressing these issues is needed to maintain appropriate pharmacovigilance as the use of these powerful and life-saving antimalarials increases. C1 [Genovese, Raymond F.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Genovese, RF (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM Raymond.Genovese@US.Army.Mil NR 44 TC 17 Z9 23 U1 0 U2 8 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD JUN PY 2008 VL 82 IS 6 BP 379 EP 385 DI 10.1007/s00204-007-0252-z PG 7 WC Toxicology SC Toxicology GA 306MH UT WOS:000256252000006 PM 17972063 ER PT J AU Ngaosuwankul, P Pongtanalert, P Engering, A Chaiyaroj, SC AF Ngaosuwankul, Piyaporn Pongtanalert, Piyapong Engering, Aneke Chaiyaroj, Sansanee C. TI Differential Gene Expression Profiles of Human Monocyte-Derived Antigen Presenting Cells in Response to Penicillium marneffei: Roles of DC-SIGN (CD209) in Fungal Cell Uptake SO ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY LA English DT Article ID FACTOR GM-CSF; DENDRITIC CELLS; ASPERGILLUS-FUMIGATUS; IN-VITRO; FUNGICIDAL ACTIVITY; IMMUNE-RESPONSES; SOUTHEAST-ASIA; RECEPTOR; INFECTION; GAMMA AB DNA microarray technology was used to determine the gene expression profile of human monocyte-derived macrophages (hMDMs) after stimulation by Penicillium marneffei yeast. The expression levels of 175 macrophage genes were found to be altered by a minimum of two-fold in magnitude following 4 hours of P. marneffei exposure. Among those, 41 genes were upregulated in activated hMDMs while 134 genes were downregulated. Real-time PCR and RT-PCR were performed to further examine gene expression associated with the inflammatory response. Increased levels of TNF-alpha and IL-1 beta gene expression in both hMDMs and human monocyte-derived dendritic cells (hMoDCs) were observed after stimulation by P. marneffei yeast. Furthermore, the genes encoding T-bet, IL-6 and ICAM-1 were also upregulated in hMDMs. Functional analysis of the adhesion of P. marneffei to dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) was performed in hMoDCs since the microarray data revealed an increased expression of DC-SIGN in activated hMDMs. We found that DC-SIGN-Fc bound preferentially to P. marneffei yeast rather than to conidia. Moreover, an anti-DC-SIGN monoclonal antibody inhibited the binding of P. marneffei yeast to hMoDCs, but did not inhibit endocytosis of P. marneffei yeast. The mannose receptor, on the other hand, was important in both adhesion and phagocytosis. These results suggest that P. marneffei may exploit DC-SIGN as a receptor to facilitate the systemic spread of infection. Taken together, our study demonstrates the usefulness of microarray technology in generating valuable expression data to permit conventional immunologic investigations of host-fungal interactions. C1 [Ngaosuwankul, Piyaporn; Pongtanalert, Piyapong; Chaiyaroj, Sansanee C.] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand. [Engering, Aneke] Armed Forces Res Inst Med Sci, Dept Immunol, Bangkok 10400, Thailand. [Chaiyaroj, Sansanee C.] Chulabhorn Res Inst, Pharmacol Lab, Bangkok, Thailand. RP Chaiyaroj, SC (reprint author), Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand. EM scscy@mahidol.ac.th FU Thailand Research Fund (TRF) [PHD/0087/2547]; Faculty of Graduate Studies, Mahidol University; BIOTEC; National Science and Technology Development Agency (NSTDA) FX Piyaporn Ngaosuwankul is a Ph.D student of Mahidol University supported by The Royal Golden Jubilee Ph.D. Scholarship (PHD/0087/2547) of the Thailand Research Fund (TRF). Piyapong Pongtanalert was supported by the Faculty of Graduate Studies, Mahidol University, under the Research Assistant Program. This work was funded by BIOTEC, National Science and Technology Development Agency (NSTDA). We would like to thank Mr. Rachasak Boonhok for providing additional information for this study. NR 33 TC 1 Z9 1 U1 0 U2 2 PU ALLERGY IMMUNOL SOC THAILAND, PI BANGKOK PA MAHIDOL UNIV, DEPT MICROBIOL IMMUNOL, FACULTY TROPICAL MED, BANGKOK 10400, THAILAND SN 0125-877X J9 ASIAN PAC J ALLERGY JI Asian Pac. J. Allergy Immunol. PD JUN-SEP PY 2008 VL 26 IS 2-3 BP 151 EP 163 PG 13 WC Allergy; Immunology SC Allergy; Immunology GA 375ZQ UT WOS:000261152700011 PM 19054934 ER PT J AU Elphic, RC Chu, P Hahn, S James, MR Lawrence, DJ Prettyman, TH Johnson, JB Podgorney, RK AF Elphic, R. C. Chu, P. Hahn, S. James, M. R. Lawrence, D. J. Prettyman, T. H. Johnson, J. B. Podgorney, R. K. TI Surface and downhole prospecting tools for planetary exploration: Tests of neutron and gamma ray probes SO ASTROBIOLOGY LA English DT Article; Proceedings Paper CT Fall Meeting of the American-Geophysical-Union CY DEC, 2006 CL San Francisco, CA SP Amer Geophys Union DE neutron; gamma ray; prospecting; water; hydrogen; habitat ID LUNAR SOUTH-POLE; MARS ODYSSEY; ICE DEPOSITS; NEAR-SURFACE; GROUND ICE; WATER ICE; HYDROGEN; SPECTROMETER; MISSION; PAYLOAD AB The ability to locate and characterize icy deposits and other hydrogenous materials on the Moon and Mars will help us understand the distribution of water and, therefore, possible habitats at Mars, and may help us locate primitive prebiotic compounds at the Moon's poles. We have developed a rover-borne neutron probe that localizes a near-surface icy deposit and provides information about its burial depth and abundance. We have also developed a borehole neutron probe to determine the stratigraphy of hydrogenous subsurface layers while operating within a drill string segment. In our field tests, we have used a neutron source to "illuminate" surrounding materials and gauge the instruments' efficacy, and we can simulate accurately the observed instrument responses using a Monte Carlo nuclear transport code (MCNPX). An active neutron source would not be needed for lunar or martian near-surface exploration: cosmic-ray interactions provide sufficient neutron flux to depths of several meters and yield better depth and abundance sensitivity than an active source. However, for deep drilling (>= 10 m depth), a source is required. We also present initial tests of a borehole gamma ray lithodensity tool and demonstrate its utility in determining soil or rock densities and composition. C1 [Elphic, R. C.] NASA Ames Res Ctr, Planetary Syst Branch, Space Sci & Astrobiol Div, Moffett Field, CA 94035 USA. [Chu, P.] Honeybee Robot Spacecraft Mech Corp, Houston, TX USA. [Hahn, S.] Los Alamos Natl Lab, Space Instrumentat & Syst Engn Grp, Los Alamos, NM USA. [James, M. R.] Los Alamos Natl Lab, Nucl Design & Risk Anal, Los Alamos, NM USA. [Lawrence, D. J.] Johns Hopkins Univ, Appl Phys Lab, Dept Space, Planetary Explorat Grp, Laurel, MD USA. [Prettyman, T. H.] Planetary Sci Inst, Tucson, AZ USA. [Johnson, J. B.] USA, Corps Engineers, ERDC Cold Reg & Engn Lab, Ft Wainwright, AR USA. [Podgorney, R. K.] Idaho Natl Lab, Modeling & Measurement Dept, Idaho Falls, ID USA. RP Elphic, RC (reprint author), NASA Ames Res Ctr, Planetary Syst Branch, Space Sci & Astrobiol Div, Mail Stop 245-3, Moffett Field, CA 94035 USA. EM richard.c.elphic@nasa.gov RI Lawrence, David/E-7463-2015; OI Lawrence, David/0000-0002-7696-6667; Prettyman, Thomas/0000-0003-0072-2831 NR 37 TC 8 Z9 8 U1 0 U2 7 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1531-1074 J9 ASTROBIOLOGY JI Astrobiology PD JUN PY 2008 VL 8 IS 3 BP 639 EP U15 DI 10.1089/ast.2007.0163 PG 15 WC Astronomy & Astrophysics; Biology; Geosciences, Multidisciplinary SC Astronomy & Astrophysics; Life Sciences & Biomedicine - Other Topics; Geology GA 336SO UT WOS:000258385100012 PM 18554085 ER PT J AU Napolitano, PG Wakefield, CL Elliott, DE Doherty, DA Magann, EF AF Napolitano, Peter G. Wakefield, Charles L. Elliott, Dawn E. Doherty, Dorota A. Magann, Everett F. TI Umbilical cord plasma homocysteine concentrations at delivery in pregnancies complicated by pre-eclampsia SO AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY LA English DT Article DE homocysteine; hyperhomocysteinemia; pre-eclampsia; umbilical cord plasma; umbilical cord blood ID HOMOCYST(E)INE LEVELS; VASCULAR-DISEASE; RISK-FACTOR AB Aim: To determine whether homocysteine concentrations in umbilical cord plasma of neonates born to mothers with pre-eclampsia are elevated compared to concentrations in neonates born to normotensive women. Method: Maternal blood from eight women with pre-eclampsia and ten women without pre-eclampsia was collected on admission for labour. Cord blood was collected from these same pregnancies at delivery. Plasma was extracted and stored at -70 degrees C. Samples were batch-analysed for homocysteine. Result: Maternal plasma homocysteine levels were observed to be significantly higher in the pregnancies complicated by pre-eclampsia compared to the control pregnancies (P = 0.043) with median levels of 5.4 mu mol/L (interquartile range (IQR) 4.6-7.9; range 3.6-16.7) versus 4.1 mu mol/L (IQR 3.4-5.1, range 3.1-6.7). Homocysteine concentrations in umbilical cord plasma in pregnancies complicated by pre-eclampsia were also significantly higher compared to those in normotensive pregnancies (P = 0.016) with median concentration levels of 5.3 mu mol/L (IQR 4.8-7.2, range 2.5-16.6) versus 3.8 mu mol/L (IQR 2.8-4.4, range 0.8-1.6). Conclusion: Both maternal and umbilical cord plasma homocysteine concentrations were elevated in pregnancies complicated by pre-eclampsia compared to normotensive controls. C1 [Napolitano, Peter G.; Wakefield, Charles L.; Magann, Everett F.] Madigan Army Med Ctr, Dept Obstet & Gynecol, Tacoma, WA 98431 USA. [Elliott, Dawn E.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA. [Doherty, Dorota A.; Magann, Everett F.] Univ Western Australia, Sch Women & Infants Hlth, Perth, WA 6009, Australia. RP Magann, EF (reprint author), Naval Med Ctr, Dept Obstet & Gynecol, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA. EM Everett.Magann@med.navy.mil NR 20 TC 2 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0004-8666 J9 AUST NZ J OBSTET GYN JI Aust. N. Z. J. Obstet. Gynaecol. PD JUN PY 2008 VL 48 IS 3 BP 261 EP 265 DI 10.1111/j.1479-828X.2008.00864.x PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 309DV UT WOS:000256441800008 PM 18532956 ER PT J AU Rickards, CA Cohen, KD Bergeron, LL Burton, L Khatri, PJ Lee, CT Ryan, KL Cooke, WH Doerr, DF Lurie, KG Convertino, VA AF Rickards, Caroline A. Cohen, Kenneth D. Bergeron, Lindsey L. Burton, Lubrina Khatri, Prateek J. Lee, Christopher T. Ryan, Kathy L. Cooke, William H. Doerr, Don F. Lurie, Keith G. Convertino, Victor A. TI Inspiratory resistance, cerebral blood flow velocity, and symptoms of acute hypotension SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE impedance threshold device; hemodynamic oscillations; cerebral blood flow regulation; squat-stand test; hypotension ID INTRATHORACIC PRESSURE REGULATION; HEART-RATE-VARIABILITY; ORTHOSTATIC HYPOTENSION; HEMODYNAMIC-RESPONSES; CENTRAL HYPOVOLEMIA; CARDIAC-ARREST; IMPEDANCE; HUMANS; AUTOREGULATION; STRESS AB Introduction: Symptoms of orthostatic intolerance, e.g., following prolonged bed rest and microgravity exposure, are associated with reductions in cerebral blood flow. We tested the hypothesis that spontaneously breathing through an impedance threshold device (ITD) would attenuate the fall in cerebral blood flow velocity (CBFV) during a hypotensive orthostatic challenge and reduce the severity of reported symptoms. Methods: While breathing through either an active ITD (-7 cm H(2)O inspiratory impedance) or a sham ITD (no impedance), 19 subjects performed a squat stand test (SST). Symptoms upon stand were recorded on a 5-point scale (1 = normal; 5 = faint) of subject-perceived rating (SPR). To address our hypothesis, only data from symptomatic subjects (SPR > 1 during the sham trial) were analyzed (N = 9). Mean arterial blood pressure (MAP) and mean CBFV were measured continuously throughout the SST and analyzed in time and frequency domains. Results: Breathing with the active ITD during the SST reduced the severity of orthostatic symptoms in eight of the nine symptomatic subjects (sham ITD SPR 1.9 +/- 0.1; active ITD SPR, 1.1 +/- 0.1), but there was no statistically distinguishable difference in the reduction of mean CBFV between the two trials (sham ITD, -39 +/- 3% vs. active ITD, -44 +/- 3%). High frequency oscillations in mean CBFV, however, were greater during the active ITD trial (7.8 +/- 2.6 cm . s(-2)) compared with the sham ITD trial (2.5 +/- 0.9 cm . s(-2)). Conclusions: Higher oscillations in CBFV while breathing with the active ITD may account for the reduction in symptom severity during orthostatic hypotension despite the same fall in absolute CBFV. C1 [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cohen, Kenneth D.] Bionet Corp, Kennedy Space Ctr, Kennedy Space Ctr, FL USA. [Bergeron, Lindsey L.; Burton, Lubrina; Khatri, Prateek J.; Lee, Christopher T.] NASA, Space Flight & Life Sci Training Program, Kennedy Space Ctr, Kennedy Space Ctr, FL USA. [Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. [Lurie, Keith G.] Adv Circulatory Syst Inc, Minneapolis, MN USA. [Lurie, Keith G.] Univ Minnesota, Dept Emergency Med, Minneapolis, MN 55455 USA. [Lurie, Keith G.] Hennepin Cty Med Ctr, Minneapolis Med Res Fdn, Minneapolis, MN 55415 USA. RP Rickards, CA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM caroline.rickards@us.army.mil NR 34 TC 11 Z9 11 U1 0 U2 5 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 2008 VL 79 IS 6 BP 557 EP 564 DI 10.3357/ASEM.2149.2008 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 306TA UT WOS:000256269500001 PM 18581938 ER PT J AU Jimenez, C Mathieu, J Peinnequin, A Carter, R Alonso, A Melin, B AF Jimenez, Chantal Mathieu, Jacques Peinnequin, Andre Carter, Robert, III Alonso, Antonia Melin, Bruno TI Immune function during and after 60 min of moderate exercise wearing protective clothing SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE exercise; hyperthermia; catecholamines; cortisol; leukocyte subsets; lymphocyte subsets; TNF-alpha mRNA ID TUMOR-NECROSIS-FACTOR; ENDURANCE EXERCISE; HEAT-STRESS; LYMPHOCYTE SUBPOPULATIONS; COLD-EXPOSURE; WHOLE-BLOOD; TNF-ALPHA; HUMANS; LEUKOCYTE; PLASMA AB Introduction: As exercise while wearing protective clothing exacerbates body heat storage compared to exercise in the heat, and as exercise alters immune responses, it appeared worthwhile to examine immune and stress responses while wearing protective clothing during moderate exercise. Methods: Eight subjects completed two bouts of exercise at 45% VO2max in a thermoneutral environment: once while wearing shorts only (Control trial, CON) and again while wearing protective clothing (PRO). Venous blood samples were taken to analyze TNF-alpha mRNA by RT-PCR in LPS stimulated blood, plasma catecholamines, and cortisol. Blood cell count was analyzed by flow cytometry. Rectal temperature (T-re) was monitored continuously. Results: Exercise with PRO resulted in significantly greater increases in T-re (39.2 +/- 0.2 degrees C in PRO vs. 38.0 +/- 0.1 degrees C in CON) and plasma epinephrine and norepinephrine (+70% and 150%, respectively). Plasma cortisol increased only at the end of PRO exercise (+33%). Leukocyte and lymphocyte cell count was 14% and 18% higher, respectively, but there were no significant changes in T cytotoxic and NK cell counts compared to the CON trial. Only T helper lymphocyte count was lower (-29%). During both exercise trials, T helper lymphocytes were significantly decreased at the end of exercise and recovery. With or without protective clothing, exercise was associated with an inhibition of TNF-alpha expression in stimulated monocytes (similar to -50% at min 20 and 40, and similar to -30% at min 60). Discussion: Protective clothing wearing induces significant thermal challenge during exercise. The inhibition of TNF-alpha appears to be mediated primarily by exercise and not the added thermal load associated with protective clothing. C1 [Jimenez, Chantal; Mathieu, Jacques; Peinnequin, Andre; Alonso, Antonia; Melin, Bruno] Ctr Rech Serv Sante Armees, Dept Facteurs Humains, F-38702 La Tronche, France. [Carter, Robert, III] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Jimenez, C (reprint author), Ctr Rech Serv Sante Armees, Dept Facteurs Humains, 24 Ave Maquis du Gresivaudan,BP 87, F-38702 La Tronche, France. EM chantal.jimenez@gmail.com NR 30 TC 5 Z9 5 U1 1 U2 5 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 2008 VL 79 IS 6 BP 570 EP 576 DI 10.3357/ASEM.2226.2008 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 306TA UT WOS:000256269500003 PM 18581940 ER PT J AU Coleman, ME Thran, B Morse, SS Hugh-Jones, M Massulik, S AF Coleman, Margaret E. Thran, Brandolyn Morse, Stephen S. Hugh-Jones, Martin Massulik, Stacey TI Inhalation anthrax: Dose response and risk analysis SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article ID BIOTERRORISM; SPORES; PATHOGENESIS; INFECTION; VIRULENCE; OUTBREAKS; SEVERITY; 1ST AB The notion that inhalation of a single Bacillus anthracis spore is fatal has become entrenched nearly to the point of urban legend, in part because of incomplete articulation of the scientific basis for microbial risk assessment, particularly dose-response assessment. Risk analysis (ie, risk assessment, risk communication, risk management) necessitates transparency: distinguishing scientific facts, hypotheses, judgments, biases in interpretations, and potential misinformation. The difficulty in achieving transparency for biothreat risk is magnified by misinformation and poor characterization of both dose-response relationships and the driving mechanisms that cause susceptibility or resistance to disease progression. Regrettably, this entrenchment unnecessarily restricts preparedness planning to a single response scenario: decontaminate until no spores are detectable in air, water, or on surfaces - essentially forcing a zero-tolerance policy inconsistent with the biology of anthrax. We present evidence about inhalation anthrax dose-response relationships, including reports from multiple studies documenting exposures insufficient to cause inhalation anthrax in laboratory animals and humans. The emphasis of the article is clarification about what is known from objective scientific evidence for doses of anthrax spores associated with survival and mortality. From this knowledge base, we discuss the need for future applications of more formal risk analysis processes to guide development of alternative non-zero criteria or standards based on science to inform preparedness planning and other risk management activities. C1 [Coleman, Margaret E.; Massulik, Stacey] Syracuse Res Corp, Ctr Environm Sci, N Syracuse, NY USA. [Thran, Brandolyn] USA, Ctr Hlth Promot & Prevent Med, Environm Hlth Risk Assessment Program, Aberdeen Proving Ground, MD USA. [Morse, Stephen S.] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA. [Hugh-Jones, Martin] Louisiana State Univ, Dept Environm Sci, Baton Rouge, LA 70803 USA. RP Coleman, ME (reprint author), Syracuse Res Corp, Ctr Environm Sci, N Syracuse, NY USA. FU NIAID NIH HHS [5U54AI057158]; PHS HHS [U90/CCU224241] NR 67 TC 23 Z9 24 U1 0 U2 7 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD JUN PY 2008 VL 6 IS 2 BP 147 EP 159 DI 10.1089/bsp.2007.0066 PG 13 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 321RY UT WOS:000257325400010 PM 18582166 ER PT J AU Xue, F Hilakivi-Clarke, LA Maxwell, GL Hankinson, SE Michels, KB AF Xue, Fei Hilakivi-Clarke, Leena A. Maxwell, G. Larry Hankinson, Susan E. Michels, Karin B. TI Infant feeding and the incidence of endometrial cancer SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID BREAST-CANCER; BIRTH-WEIGHT; RISK-FACTORS; YOUNG-WOMEN; HUMAN-MILK; TESTICULAR CANCER; EXPOSURE; METAANALYSIS; APOPTOSIS; ETIOLOGY AB Biological mechanisms could support both an inverse and a direct association between exposure to breast milk in infancy and the risk of cancer. Having been breast-fed has been investigated in relation to the risk of breast and other cancer sites, and conflicting results have been reported. The association between infant feeding and the risk of endometrial cancer has not been explored. From 1976 to 2004, we followed 74,757 cancer-free participants in the Nurses' Health Study who had not undergone hysterectomy. Information on infant feeding was self-reported by study participants. A total of 708 incident cases of endometrial cancer were diagnosed during follow-up. After adjusting for age, family history of endometrial cancer, birth weight, premature birth, and birth order, the incidence of endometrial cancer was not associated with ever having been breastfed (hazards ratio, 0.94; 95% confidence interval, 0.79-1.11) or duration of having been breast-fed [hazards ratio (95% confidence interval): 1.11 (0.80-1.54), 0.84 (0.62-1.13), 1.02 (0.79-1.31), respectively, for <=, 4-8, and >= 9 months of having been breastfed; P for trend = 0.88]. There was no significant effect modification by menopausal status, anthropometric factors (somatotype at age 5 or 10 years, body mass index at age 18 years, or current body mass index), or by other early-life exposures (birth weight, premature birth or exposure to parental smoking in childhood). Additional adjustment for adulthood risk factors of endometrial cancer did not materially change the results. Having been breast-fed was not associated with the incidence of endometrial cancer in this cohort, but statistical power for analyses restricted to premenopausal women was limited. C1 [Xue, Fei; Michels, Karin B.] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA. [Hankinson, Susan E.; Michels, Karin B.] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. [Hankinson, Susan E.; Michels, Karin B.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Xue, Fei; Hankinson, Susan E.; Michels, Karin B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Hilakivi-Clarke, Leena A.] Georgetown Univ, Lombardi Comprehens Canc Ctr, Dept Oncol, Washington, DC USA. [Maxwell, G. Larry] US Mil Canc Inst, Walter Reed Army Med Ctr, Washington, DC USA. RP Xue, F (reprint author), Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Dept Obstet Gynecol & Reprod Biol, 221 Longwood Ave, Boston, MA 02115 USA. EM n2fei@channing.harvard.edu FU NCI NIH HHS [CA87969, P01 CA087969, P01 CA087969-08] NR 34 TC 3 Z9 4 U1 1 U2 2 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JUN PY 2008 VL 17 IS 6 BP 1316 EP 1321 DI 10.1158/1055-9965.EPI-08-0108 PG 6 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 315PC UT WOS:000256890900004 PM 18541614 ER PT J AU Bobe, G Sansbury, LB Albert, PS Cross, AJ Kahle, L Ashby, J Slattery, ML Caan, B Paskett, E Iber, F Kikendall, JW Lance, P Daston, C Marshall, JR Schatzkin, A Lanza, E AF Bobe, Gerd Sansbury, Leah B. Albert, Paul S. Cross, Amanda J. Kahle, Lisa Ashby, Jason Slattery, Martha L. Caan, Bette Paskett, Electra Iber, Frank Kikendall, James Walter Lance, Peter Daston, Cassandra Marshall, James R. Schatzkin, Arthur Lanza, Elaine TI Dietary flavonoids and colorectal adenoma recurrence in the polyp prevention trial SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID ACTIVATOR PROTEIN-1; CANCER CELLS; QUERCETIN; RISK; INTERVENTION; HEALTH; FIBER; TUMORIGENESIS; MODULATION; MECHANISMS AB Two recent case-control studies suggested that some flavonoid subgroups may play a role in preventing colorectal cancer. Previous prospective cohort studies generally reported no association; however, only a small subset of flavonoids was evaluated and partial flavonoid databases were used. We used the newly constructed U.S. Department of Agriculture flavonoid database to examine the association between consumption of total flavonoids, 6 flavonoid subgroups, and 29 individual flavonoids with adenomatous polyp recurrence in the Polyp Prevention Trial. The Polyp Prevention Trial was a randomized dietary intervention trial, which examined the effectiveness of a low-fat, high-fiber, high-fruit, and high-vegetable diet on adenoma recurrence. Intakes of flavonoids were estimated from a food frequency questionnaire. Multivariate logistic regression models (adjusted for age, body mass index, sex, regular non-steroidal anti-inflammatory use, and dietary fiber intake) were used to estimate odds ratios and 95% confidence intervals for both any and advanced adenoma recurrence within quartiles of energy-adjusted flavonoid intake (baseline, during the trial, and change during the trial). Total flavonoid intake was not associated with any or advanced adenoma recurrence. However, high intake of flavonols, which are at greater concentrations in beans, onions, apples, and tea, was associated with decreased risk of advanced adenoma recurrence (4th versus 1st quartile during the trial; odds ratio, 0.24; 95% confidence interval, 0.11, 0.53; P-trend = 0.0006). Similar inverse associations were observed to a smaller extent for isoflavonoids, the flavonol kaempferol, and the isoflavonoids genistein and formononetin. Our data suggest that a flavonol-rich diet may decrease the risk of advanced adenoma recurrence. C1 [Bobe, Gerd; Lanza, Elaine] NCI, Lab Canc Prevent, Ctr Canc Res, Bethesda, MD 20892 USA. [Bobe, Gerd] NCI, Canc Prevent Fellowship Program, Off Prevent, Bethesda, MD 20892 USA. [Sansbury, Leah B.] NCI, Epidemiol & Genet Res Program, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA. [Albert, Paul S.] NCI, Biometr Res Branch, Div Canc Treatment & Diag, Bethesda, MD 20892 USA. [Cross, Amanda J.] NCI, Nutrit Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Kahle, Lisa; Ashby, Jason] Informat Management Serv Inc, Rockville, MD USA. [Slattery, Martha L.] Univ Utah, Salt Lake City, UT USA. [Caan, Bette] Kaiser Fdn Res Inst, Oakland, CA 94609 USA. [Paskett, Electra] Ohio State Canc Ctr, Columbus, OH USA. [Iber, Frank] Edward Hines Jr Hosp, Vet Affairs Med Ctr, Hines, IL USA. [Kikendall, James Walter] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Lance, Peter] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA. [Daston, Cassandra] Daston Commun, Chapel Hill, NC USA. [Marshall, James R.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. RP Bobe, G (reprint author), NCI, Lab Canc Prevent, Room 110,Bldg 576, Frederick, MD 21702 USA. EM gb246f@nih.gov RI Lance, Peter/I-2196-2014 OI Lance, Peter/0000-0003-2944-1881 FU Intramural NIH HHS [Z01 BC010025-12] NR 56 TC 53 Z9 59 U1 2 U2 14 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JUN PY 2008 VL 17 IS 6 BP 1344 EP 1353 DI 10.1158/1055-9965.EPI-07-0747 PG 10 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 315PC UT WOS:000256890900008 PM 18559549 ER PT J AU Ellsworth, RE Zhu, KM Bronfman, L Gutchell, V Hooke, JA Shriver, CD AF Ellsworth, Rachel E. Zhu, Kangmin Bronfman, Lee Gutchell, Veronica Hooke, Jeffrey A. Shriver, Craig D. TI The Clinical Breast Care Project: an important resource in investigating environmental and genetic contributions to breast cancer in African American women SO CELL AND TISSUE BANKING LA English DT Article DE breast cancer; African American women; socioeconomic; molecular ID RACIAL-DIFFERENCES; UNITED-STATES; PREVENTION; CARCINOMA; PARTICIPATION; RECRUITMENT; POPULATIONS; TRIALS; WHITE; STAGE AB Age at diagnosis, pathological characteristics, and tumor behavior differ between African American (AAW) and Caucasian women (CW) with breast cancer, with AAW having more aggressive tumors and higher mortality rates. Although both societal and molecular contributions to these disparities have been suggested, the African American population has traditionally been under-represented in research and clinical protocols, limiting the power of epidemiologic and molecular studies to provide better understanding of disease pathogenesis in this minority population. The Clinical Breast Care Project (CBCP) has developed a large tissue and blood repository from patients undergoing treatment for breast cancer, with previous history of breast cancer, counseled in the Risk Reduction Clinic, screened by routine mammography, or undergoing elective reductive mammoplasty. Recruitment of AAW into the CBCP was successful; 25% of the 2,454 female patients were African American, including 35% disease-free, 3% high-risk, 40% benign, 8% preinvasive and 14% with invasive breast disease. More than 500 data fields regarding lifestyle choices, socioeconomic status, health history and geography were collected from all participants, and all consenting individuals provided blood specimens for genomic and proteomic studies. Tissues were collected from all patients undergoing surgical procedures using protocols that preserve the macromolecules for downstream research applications. In addition, patients were followed after diagnosis, with > 85% of patients providing ongoing and updated demographic and clinical information. Thus, recruitment efforts in the CBCP have resulted in collection of well-annotated information and research-quality specimens from a large number of AAW. This unique resource will allow for the identification of biological and environmental factors associated with the identification of genetic and non-genetic factors associated with the occurrence, detection, prognosis, or survival of breast cancer in AAW. C1 [Ellsworth, Rachel E.] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Zhu, Kangmin] US Mil Canc Inst, Washington, DC 20307 USA. [Bronfman, Lee; Gutchell, Veronica; Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Ellsworth, RE (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org NR 23 TC 5 Z9 6 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1389-9333 J9 CELL TISSUE BANK JI Cell Tissue Banking PD JUN PY 2008 VL 9 IS 2 BP 109 EP 120 DI 10.1007/s10561-007-9054-z PG 12 WC Cell Biology; Engineering, Biomedical SC Cell Biology; Engineering GA 307YL UT WOS:000256355400005 PM 17929197 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI "Poor burn?" The Antietam conspiracy that wasn't SO CIVIL WAR HISTORY LA English DT Article; Proceedings Paper CT Annual Meeting of the Society-for-Military-History CY 2007 CL Frederick, MD SP Soc Mil Hist C1 USA, Command & Gen Staff Coll, Ft Leaveworth, KS USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leaveworth, KS USA. NR 40 TC 2 Z9 2 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD JUN PY 2008 VL 54 IS 2 BP 146 EP 175 PG 30 WC History SC History GA 313FN UT WOS:000256726600002 ER PT J AU Keller, CB Kamphoefner, WD AF Keller, Christian B. Kamphoefner, Walter D. TI Germans in the Civil War. The letters they wrote home SO CIVIL WAR HISTORY LA English DT Book Review C1 [Keller, Christian B.] USA, Command & Gen Staff Coll, Ft Belvoir, VA USA. RP Keller, CB (reprint author), USA, Command & Gen Staff Coll, Ft Belvoir, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD JUN PY 2008 VL 54 IS 2 BP 198 EP 200 PG 3 WC History SC History GA 313FN UT WOS:000256726600008 ER PT J AU Keller, CB AF Keller, Christian B. TI Long Road to liberty: The odyssey of a German regiment in the Yankee army SO CIVIL WAR HISTORY LA English DT Book Review C1 [Keller, Christian B.] USA, Command & Gen Staff Coll, Ft Belvoir, VA USA. RP Keller, CB (reprint author), USA, Command & Gen Staff Coll, Ft Belvoir, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 EI 1533-6271 J9 CIVIL WAR HIST JI Civil War Hist. PD JUN PY 2008 VL 54 IS 2 BP 198 EP 200 PG 3 WC History SC History GA 313FN UT WOS:000256726600007 ER PT J AU Keller, CB AF Keller, Christian B. TI August Willich's Gallant Dutchmen: Civil War Letters from the 32nd Indiana infantry SO CIVIL WAR HISTORY LA English DT Book Review C1 [Keller, Christian B.] USA, Command & Gen Staff Coll, Ft Belvoir, VA USA. RP Keller, CB (reprint author), USA, Command & Gen Staff Coll, Ft Belvoir, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 USA SN 0009-8078 EI 1533-6271 J9 CIVIL WAR HIST JI Civil War Hist. PD JUN PY 2008 VL 54 IS 2 BP 198 EP 200 PG 3 WC History SC History GA 313FN UT WOS:000256726600006 ER PT J AU Kifude, CM Rajasekariah, HG Sullivan, DJ Stewart, VA Angov, E Martin, SK Diggs, CL Waitumbi, JN AF Kifude, Carolyne M. Rajasekariah, Halli G. Sullivan, David J., Jr. Stewart, V. Ann Angov, Evelina Martin, Samuel K. Diggs, Carter L. Waitumbi, John N. TI Enzyme-linked immunosorbent assay for detection of Plasmodium falciparum histidine-rich protein 2 in blood, plasma, and serum SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID RAPID DIAGNOSTIC-TESTS; MALARIA PARASITES; MICROSCOPY; ELISA; MISDIAGNOSIS; EFFICACY; CULTURE; PFHRP2; PLDH AB Microscopy, the gold standard for the detection and quantification of malaria parasites in blood, is in many aspects deficient for this purpose. The method is poorly reproducible and can be inaccurate because Plasmodium falciparum parasites sequester for a portion of each asexual cycle. Due to these deficiencies, biomarkers such as P. falciparum histidine-rich protein 2 (PfHRP2) are increasingly being used. In this study, we evaluated the use of a commercial PfHRP2 enzyme-linked immunosorbent assay (ELISA) kit with some procedural modifications. We determined the linear range of the assay, including the lower limits of detection and quantitation, using recombinant PfHRP2 (rPfHRP2). In 10 repeat experiments, the linear range of optical densities (ODs) at 450 to 650 nm was from 0.05 +/- 0.002 to 2.28 +/- 0.042,corresponding to 3.91 to 250 ng/ml of rPfHRP2. The coefficient of variation (CV) at each target concentration ranged from 1.93 to 8.07%. Using cultured parasites, we confirmed the linear range of ODs as well as the association between the PfHRP2 ELISA results and the microscopic parasite densities. For whole-blood samples spiked with cultured, washed, ring-stage-infected red blood cells (iRBCs), the linear range was 11.7 to 750 iRBCs/mu l, with CVs of 0.29 to 7.56%. The same spiked samples evaluated by microscopists had similar sensitivities, but the CVs were unacceptably high (20.7 to 161.6%). Stock rPfHRP2 was stable through four freeze-thaw cycles (P < 0.05; paired t test). When different patient sample types at different concentrations within the linear range of the assay are compared, the recoveries of PfHRP2 from blood and serum were within +/- 20%, whereas the recoveries from plasma ranged between + 35 and -41%. We conclude that PfHRP2 ELISA using whole-blood and serum samples is a suitable adjunct to microscopy and could ultimately benefit malaria intervention trials. C1 [Kifude, Carolyne M.; Stewart, V. Ann; Martin, Samuel K.; Waitumbi, John N.] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu 00621, Kenya. [Rajasekariah, Halli G.] Cellabs Pty Ltd, Brookvale, NSW 2001, Australia. [Sullivan, David J., Jr.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Angov, Evelina] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Diggs, Carter L.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. RP Waitumbi, JN (reprint author), Kenya Govt Med Res Ctr, Walter Reed Project, United Nations Ave Gigiri,Village Market, Nairobi 00621, Kenya. EM jwaitumbi@wrp-ksm.org FU Malaria Vaccine Development Program; United States Agency for International Development FX This work was supported by a grant from the Malaria Vaccine Development Program, United States Agency for International Development. We thank Douglas Walsh for critical review of the manuscript. This work is published with the permission of the Director, Kenya Medical Research Institute.; The material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/ or publication. The opinions or assertions contained herein are our private views and are not to be construed as official, or as reflecting true views, of the U. S. Department of the Army or the U. S. Department of Defense. NR 31 TC 36 Z9 37 U1 1 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JUN PY 2008 VL 15 IS 6 BP 1012 EP 1018 DI 10.1128/CVI.00385-07 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 340TD UT WOS:000258667000016 PM 18367583 ER PT J AU Wells, JM van Hoeven, KH Abadie, JM AF Wells, J. M. van Hoeven, K. H. Abadie, J. M. TI Serum free light chain assays in clinical practice: Impact of impaired renal function oil interpretation SO CLINICAL CHEMISTRY LA English DT Meeting Abstract CT 60th Annual Meeting of the American-Association-for-Clinical-Chemistry CY JUL 27-31, 2008 CL Washington, DC SP Amer Assoc Clin Chem C1 [Wells, J. M.; Abadie, J. M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [van Hoeven, K. H.] Binding Site Inc, San Diego, CA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD JUN PY 2008 VL 54 IS 6 SU S MA C91 BP A128 EP A128 PG 1 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 307NN UT WOS:000256325700396 ER PT J AU Calhoun, JH Murray, CK Manring, MM AF Calhoun, Jason H. Murray, Clinton K. Manring, M. M. TI Multidrug-resistant organisms in military wounds from iraq and afghanistan SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article; Proceedings Paper CT 17th Annual Meeting of the Musculoskeletal-Infection-Society CY 2007 CL San Diego, CA SP Musculoskeletal Infect Soc ID VENTILATOR-ASSOCIATED PNEUMONIA; INTENSIVE-CARE-UNIT; FOREIGN-BODY INFECTION; GRAM-NEGATIVE BACTERIA; US ARMY SOLDIERS; WORLD-WAR-II; PSEUDOMONAS-AERUGINOSA; ACINETOBACTER-BAUMANNII; STAPHYLOCOCCUS-AUREUS; INTRAVENOUS COLISTIN AB Mortality from battlefield wounds has historically declined, thanks to better surgical management, faster transport of casualties, and improved antibiotics. Today, one of the major challenges facing U.S. military caregivers is the presence of multidrug-resistant organisms in orthopaedic extremity wounds. The most frequently identified resistant strains of bacteria are Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter calcoaceticus-baumannii complex. Overuse of broad-spectrum antibiotics may be an important factor in building resistant strains. Acinetobacter infections appear to hospital-acquired and not from an initial colonization of the injury. More research is required to give military physicians the tools they require to reduce the infection rate and defeat multidrug-resistant organisms. C1 [Calhoun, Jason H.; Manring, M. M.] Univ Missouri, Dept Orthopaed Surg, Columbia, MO 65212 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Calhoun, JH (reprint author), Univ Missouri, Dept Orthopaed Surg, MC213,DC053-00,1 Hosp Dr, Columbia, MO 65212 USA. EM calhounj@health.missouri.edu RI Manring, Maurice/E-3588-2011 OI Manring, Maurice/0000-0002-5066-2630 NR 66 TC 66 Z9 69 U1 3 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JUN PY 2008 VL 466 IS 6 BP 1356 EP 1362 DI 10.1007/s11999-008-0212-9 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 300WI UT WOS:000255855600016 PM 18347888 ER PT J AU King, C Moores, LK AF King, Christopher Moores, Lisa K. TI Controversies in mechanical ventilation: When should a tracheotomy be placed? SO CLINICS IN CHEST MEDICINE LA English DT Article ID INTENSIVE-CARE-UNIT; PERCUTANEOUS DILATATIONAL TRACHEOSTOMY; PROLONGED TRANSLARYNGEAL INTUBATION; UNPLANNED ENDOTRACHEAL EXTUBATION; RESPIRATORY-DISTRESS SYNDROME; GUILLAIN-BARRE-SYNDROME; PROSPECTIVE MULTICENTER; NOSOCOMIAL PNEUMONIA; BEDSIDE TRACHEOSTOMY; CLINICAL PREDICTORS AB With the large and increasing population of mechanically ventilated patients, critical care physicians frequently face the dilemma of whether to perform tracheotomy. The decision is a complex one, requiring a detailed understanding of the risks and benefits of both tracheotomy and prolonged translaryngeal intubation (TLI). It also must be individualized, taking into consideration the patient's preferences and expected clinical course. This article reviews the medical literature regarding the benefits and risks of tracheotomy as compared with TLI. The authors then discuss current data regarding the optimal timing for the procedure and propose an algorithm that may aid intensivists in clinical decision making. C1 [Moores, Lisa K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [King, Christopher] Walter Reed Army Med Ctr, Washington, DC 20016 USA. RP Moores, LK (reprint author), Uniformed Serv Univ Hlth Sci, 4310 Jones Bridge Rd, Bethesda, MD 20814 USA. EM lmoores@usuhs.mil NR 91 TC 13 Z9 19 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-5231 J9 CLIN CHEST MED JI Clin. Chest Med. PD JUN PY 2008 VL 29 IS 2 BP 253 EP + DI 10.1016/j.ccm.2008.01.002 PG 12 WC Respiratory System SC Respiratory System GA 304TM UT WOS:000256132000006 PM 18440435 ER PT J AU Miao, YY Zhou, E Wang, YQ Cheeseman, BA AF Miao, Yuyang Zhou, Eric Wang, Youqi Cheeseman, Bryan A. TI Mechanics of textile composites: Micro-geometry SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE textile composites; fabrics/textiles; finite element analysis (FEA); modelling; fabric geometry AB Textile fabric geometry determines textile composite properties. Textile process mechanics determines fabric geometry. In previous papers, the authors proposed a digital element model to generate textile composite geometry by simulating the textile process. The greatest difficulty encountered with its employment in engineering practice is efficiency. A full scale fiber-based digital element analysis would consume huge computational resources. Two advances are developed in this paper to overcome the problem of efficiency. An improved contact-element formulation is developed first. The new formulation improves accuracy. As such, it permits a coarse digital element mesh. Then, a static relaxation algorithm to determine fabric micro-geometry is established to replace step-by-step textile process simulation. Employing the modified contact element formulation in the static relaxation approach, the required computer resource is only 1-2% of the resource required by the original process. Two critical issues with regards to the digital element mesh are also examined: yarn discretization and initial yarn cross-section shape. Fabric geometries derived from digital element analysis are compared to experimental results. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Miao, Yuyang; Zhou, Eric; Wang, Youqi] Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. [Cheeseman, Bryan A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wang, YQ (reprint author), Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. EM wang@mne.ksu.edu NR 7 TC 61 Z9 63 U1 3 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD JUN PY 2008 VL 68 IS 7-8 BP 1671 EP 1678 DI 10.1016/j.compscitech.2008.02.018 PG 8 WC Materials Science, Composites SC Materials Science GA 304US UT WOS:000256135200011 ER PT J AU La Scala, JJ Logan, MS Sands, JM Palmese, GR AF La Scala, John J. Logan, Matthew S. Sands, James M. Palmese, Giuseppe R. TI Composites based on bimodal vinyl ester resins with low hazardous air pollutant contents SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE polymer matrix composites (PMCs); fracture toughness; thermo-mechanical properties; dynamic mechanical thermal analysis (DMTA); styrene replacements/alternatives AB Vinyl ester (VE) resins with a bimodal distribution of molecular weights were prepared via methacrylation of epoxy monomers. Bimodal VE resins and neat polymers had viscosities and mechanical properties similar to that of commercial resins. E-glass composites were prepared and also found to have similar mechanical and thermo-mechanical properties relative to composites fabricated using commercial resins. However, the fracture toughness of the bimodal resins was superior to that of the commercial resins partially as a result of increased molecular relaxations that were manifested in a broader glass transition. Overall, bimodal resins allow for the use of low styrene content (similar to 33 wt%), while maintaining excellent thermal, mechanical, and fracture properties for the neat resins and composites. Published by Elsevier Ltd. C1 [La Scala, John J.; Sands, James M.] USA, Res Lab, AMSRD WM MC, Aberdeen Proving Ground, MD 21005 USA. [Logan, Matthew S.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Palmese, Giuseppe R.] Univ Delaware, Dept Biol & Chem Engn, Newark, DE 19716 USA. RP La Scala, JJ (reprint author), USA, Res Lab, AMSRD WM MC, Aberdeen Proving Ground, MD 21005 USA. EM jlascala@arl.army.mil NR 24 TC 7 Z9 7 U1 2 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD JUN PY 2008 VL 68 IS 7-8 BP 1869 EP 1876 DI 10.1016/j.compscitech.2008.01.003 PG 8 WC Materials Science, Composites SC Materials Science GA 304US UT WOS:000256135200036 ER PT J AU Cooke, WH Rickards, CA Ryan, KL Convertino, VA AF Cooke, William H. Rickards, Caroline A. Ryan, Kathy L. Convertino, Victor A. TI Autonomic compensation to simulated hemorrhage monitored with heart period variability SO CRITICAL CARE MEDICINE LA English DT Article DE central hypovolemia; lower body negative pressure; stroke volume; pulse pressure; blood pressure; remote medical monitoring ID BODY NEGATIVE-PRESSURE; RATE SPECTRAL-ANALYSIS; TRAUMA PATIENTS; SYMPATHOVAGAL BALANCE; FREQUENCY-DOMAIN; VITAL SIGN; MORTALITY; HUMANS; PULSE; ASSOCIATION AB Objective. To test the hypothesis that components of heart period variability track autonomic function during simulated hemorrhage in humans. Design: Prospective experimental laboratory intervention. Setting. Human physiology laboratory. Subjects: A total of 33 healthy, nonsmoking, volunteer subjects (23 men, ten women). Interventions: Progressive lower body negative pressure was applied in 5-min stages until the onset of impending cardiovascular collapse. Measurements and Main Results. The electrocardiogram, beat-by-beat finger arterial pressure, and muscle sympathetic nerve activity from the peroneal nerve were recorded continuously. Pulse pressure was calculated from the arterial pressure waveform and used as an estimate of relative changes of central blood volume. Heart period variability was assessed in both time and frequency domains. Application of lower body negative pressure caused progressive reductions of R-R interval and pulse pressure and progressive increases of muscle sympathetic nerve activity. Arterial pressures changed minimally and late. R-R interval time domain variability measures and spectral power at the high frequency (0.15-0.4 Hz) decreased progressively with lower body negative pressure (p .001). Both R-R interval high-frequency power and time domain variability measures correlated inversely with muscle sympathetic nerve activity and directly with pulse pressure (all amalgamated R 2 > .88, all p <= .001). Conclusions. Components of heart period variability track early compensatory autonomic and hemodynamic responses to progressive reduction in central blood volume. Such analyses, interpreted in conjunction with standard vital signs, may contribute to earlier assessments of the magnitude of blood volume loss during hemorrhage. C1 [Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA. [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cooke, WH (reprint author), Univ Texas San Antonio, Dept Hlth & Kinesiol, 1 UTSA Circle, San Antonio, TX 78249 USA. EM william.cooke@utsa.edu NR 37 TC 23 Z9 24 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUN PY 2008 VL 36 IS 6 BP 1892 EP 1899 DI 10.1097/CCM.0b013e3181760d0c PG 8 WC Critical Care Medicine SC General & Internal Medicine GA 310EZ UT WOS:000256513000028 PM 18496361 ER PT J AU Dubick, MA AF Dubick, Michael A. TI A treatment worth its salt? SO CRITICAL CARE MEDICINE LA English DT Editorial Material DE hypertonic saline; sepsis; hemorrhage; rats; inflammatory response ID HYPERTONIC SALINE RESUSCITATION; HEMORRHAGIC-SHOCK; DEXTRAN RESUSCITATION; FLUID RESUSCITATION; HYPOTENSION; EFFICACY; INJURY C1 USA, Inst Surg Res, San Antonio, TX USA. RP Dubick, MA (reprint author), USA, Inst Surg Res, San Antonio, TX USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUN PY 2008 VL 36 IS 6 BP 1978 EP 1979 DI 10.1097/CCM.0b013e318176aabe PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 310EZ UT WOS:000256513000054 PM 18520664 ER PT J AU Howell, SM Krivda, SJ AF Howell, Sarah M. Krivda, Stephen J. TI What is your diagnosis? The Diagnosis: Idiopathic atrophoderma of Pasini and Pierini SO CUTIS LA English DT Editorial Material C1 [Howell, Sarah M.; Krivda, Stephen J.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. RP Howell, SM (reprint author), Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD JUN PY 2008 VL 81 IS 6 BP 467 EP + PG 3 WC Dermatology SC Dermatology GA 318PD UT WOS:000257103200003 PM 18666386 ER PT J AU Kineston, DP Xia, Y Turiansky, GW AF Kineston, Donald P. Xia, Yang Turiansky, George W. TI Anetoderma: A case report and review of the literature SO CUTIS LA English DT Article ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; SECONDARY ANETODERMA; ANTIPHOSPHOLIPID ANTIBODIES; DISEASE; SKIN; ABNORMALITIES; TISSUE AB Anetoderma is a rare benign dermatosis caused by a loss of mid-dermal elastic tissue resulting in well-circumscribed areas of pouchlike herniations of flaccid skin. Anetoderma is classically categorized as either primary (idiopathic) or secondary (following an inflammatory dermatosis in the same location). We report a case of primary anetoderma (PA) occurring in a human immunodeficiency virus 1 (HIV-1)-infected man. We review the clinical presentation, possible etiologies, associated conditions, and limited treatment options of this disease. C1 [Kineston, Donald P.] Reg Support Org, Norfolk, VA USA. [Xia, Yang; Turiansky, George W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Xia, Y (reprint author), 6900 Georgia Ave NW, Washington, DC 20307 USA. EM yang.xia@amedd.army.mil NR 46 TC 5 Z9 5 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 EI 2326-6929 J9 CUTIS JI Cutis PD JUN PY 2008 VL 81 IS 6 BP 501 EP 506 PG 6 WC Dermatology SC Dermatology GA 318PD UT WOS:000257103200011 PM 18666393 ER PT J AU Kindscher, K Price, DM Castle, L AF Kindscher, Kelly Price, Dana M. Castle, Lisa TI Resprouting of Echinacea angustifolia augments sustainability of wild medicinal plant populations SO ECONOMIC BOTANY LA English DT Article DE wild harvest; medicinal plants; roots; dormancy; resprouting; overharvesting; echinacea AB Overharvest of wild Echinacea species root has been a significant concern to the herbal industry. Harvesters of wild Echinacea angustifolia showed us that even after harvesting the top 15 to 20 cm of root, some plants resprout. We marked locations of harvested plants at sites in Kansas and Montana and reexamined them two years later to see if they resprouted from remaining root reserves. Approximately 50% of the roots resprouted at both Kansas and Montana sampling sites, despite droughty weather conditions in Montana. The length of root harvested significantly affected the ability of the plant to resprout. Those plants that were more shallowly harvested and had less root length removed were more likely to resprout. These data indicate that echinacea stands can recover over time from intensive harvest if periods of nonharvest occur. Our echinacea harvest study emphasizes that the entire biology of medicinal plants must be considered when evaluating their conservation status. C1 [Kindscher, Kelly] Univ Kansas, Lawrence, KS 66047 USA. [Price, Dana M.] US Army, Corps Engineers Albuquerque Dist, Environm Resources Sect, Albuquerque, NM 87109 USA. [Castle, Lisa] Glenville State Coll, Dept Sci & Math, Glenville, WV 26351 USA. RP Kindscher, K (reprint author), Univ Kansas, 2101 Constant Ave, Lawrence, KS 66047 USA. EM Kindscher@KU.edu NR 23 TC 3 Z9 5 U1 2 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0013-0001 J9 ECON BOT JI Econ. Bot. PD JUN PY 2008 VL 62 IS 2 BP 139 EP 147 DI 10.1007/s12231-008-9016-9 PG 9 WC Plant Sciences SC Plant Sciences GA 322RA UT WOS:000257391800003 ER PT J AU Huffman, AH Youngcourt, SS Payne, SC Castro, CA AF Huffman, Ann H. Youngcourt, Satoris S. Payne, Stephanie C. Castro, Carl A. TI The importance of construct breadth when examining interrole conflict SO EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT LA English DT Article DE work-family conflict; work-nonwork conflict; job satisfaction; turnover intentions ID WORK-FAMILY CONFLICT; LIFE SATISFACTION RELATIONSHIP; SINGLE-ITEM; ORGANIZATIONAL COMMITMENT; JOB-SATISFACTION; NARROW TRAITS; ANTECEDENTS; VALIDATION; OUTCOMES; MODEL AB Research examining the influence of nonwork issues on work-related outcomes has flourished. Often, however, the breadth of the interrole conflict construct varies widely between studies. To determine if the breadth of the interrole conflict measure makes a difference, the current study compares the criterion-related validity of scores yielded by a work-nonwork conflict scale and those yielded by a work-family conflict scale using active-duty U. S. Army soldiers stationed in Germany and Italy with spouses and/ or children and without spouses or children. Results demonstrated that the two constructs are related but distinct. In addition, work-family conflict had a stronger relationship with job satisfaction and turnover intentions for employees with a spouse and/ or children than for single, childless employees, whereas work-nonwork conflict had a stronger relationship with these outcomes for single, childless employees than for employees with a spouse and/ or children. C1 [Huffman, Ann H.] No Arizona Univ, Dept Psychol, Flagstaff, AZ 86011 USA. [Huffman, Ann H.] No Arizona Univ, Coll Business, Flagstaff, AZ 86011 USA. [Youngcourt, Satoris S.] Kansas State Univ, Manhattan, KS 66506 USA. [Payne, Stephanie C.] Texas A&M Univ, College Stn, TX 77843 USA. [Castro, Carl A.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Huffman, AH (reprint author), No Arizona Univ, Dept Psychol, Flagstaff, AZ 86011 USA. EM ann.huffman@nau.edu NR 44 TC 14 Z9 15 U1 3 U2 7 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0013-1644 J9 EDUC PSYCHOL MEAS JI Educ. Psychol. Meas. PD JUN PY 2008 VL 68 IS 3 BP 515 EP 530 DI 10.1177/0013164407308472 PG 16 WC Psychology, Educational; Mathematics, Interdisciplinary Applications; Psychology, Mathematical SC Psychology; Mathematics GA 298XU UT WOS:000255721200009 ER PT J AU Kortepeter, MG Martin, JW Rusnak, JM Cieslak, TJ Warfield, KL Anderson, EL Ranadive, MV AF Kortepeter, Mark G. Martin, James W. Rusnak, Janice M. Cieslak, Theodore J. Warfield, Kelly L. Anderson, Edwin L. Ranadive, Manmohan V. TI Managing potential laboratory exposure to Ebola virus by using a patient biocontainment care unit SO EMERGING INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 46th Interscience Conference on Antimicrobial Agents and Chemotherapy CY SEP 27-30, 2006 CL San Francisco, CA ID NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; GUINEA-PIGS; INFECTION; MANAGEMENT; BIOTERRORISM; PROTECTION; DISEASES; VACCINE; MONKEYS AB In 2004, a scientist from the US Army Medical Research Institute of Infectious Diseases (USAMRIID) was potentially exposed to a mouse-adapted variant of the Zaire species of Ebola virus. The circumstances surrounding the case are presented, in addition to an update on historical admissions to the medical containment suite at USAMRIID. Research facilities contemplating work with pathogens requiring Biosafety Level 4 laboratory precautions should be mindful of the occupational health issues highlighted in this article. C1 [Kortepeter, Mark G.] USA, Med Res Inst Infect Dis, Div Virol, Attn MCMR UIV, Ft Detrick, MD 21702 USA. [Cieslak, Theodore J.] San Antonio Mil Pediat Ctr, San Antonio, TX USA. [Kortepeter, Mark G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Kortepeter, MG (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Attn MCMR UIV, 1425 Porter St, Ft Detrick, MD 21702 USA. EM mark.kortepeter@na.amedd.army.mil NR 34 TC 33 Z9 35 U1 1 U2 8 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUN PY 2008 VL 14 IS 6 BP 881 EP 887 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 309MR UT WOS:000256465100002 PM 18507897 ER PT J AU Briese, T Renwick, N Venter, M Jarman, RG Ghosh, D Kondgen, S Shrestha, SK Hoegh, AM Casas, I Adjogoua, EV Akoua-Koffi, C Myint, KS Williams, DT Chidlow, G van den Berg, R Calvo, C Koch, O Palacios, G Kapoor, V Villari, J Dominguez, SR Holmes, KV Harnett, G Smith, D Mackenzie, JS Ellerbrok, H Schweiger, B Schonning, K Chadha, MS Leendertz, FH Mishra, AC Gibbons, RV Holmes, EC Lipkin, WI AF Briese, Thomas Renwick, Neil Venter, Marietjie Jarman, Richard G. Ghosh, Dhrubaa Koendgen, Sophie Shrestha, Sanjaya K. Hoegh, A. Mette Casas, Inmaculada Adjogoua, Edgard Valerie Akoua-Koffi, Chantal Myint, Khin Saw Williams, David T. Chidlow, Glenys van den Berg, Ria Calvo, Cristina Koch, Orienka Palacios, Gustavo Kapoor, Vishal Villari, Joseph Dominguez, Samuel R. Holmes, Kathryn V. Harnett, Gerry Smith, David Mackenzie, John S. Ellerbrok, Heinz Schweiger, Brunhilde Schonning, Kristian Chadha, Mandeep S. Leendertz, Fabian H. Mishra, A. C. Gibbons, Robert V. Holmes, Edward C. Lipkin, W. Ian TI Global distribution of novel rhinovirus genotype SO EMERGING INFECTIOUS DISEASES LA English DT Article ID RESPIRATORY-TRACT; CHILDREN; INFECTIONS; PATHOGENS; ILLNESS AB Global surveillance for a novel rhinovirus genotype indicated its association with community outbreaks and pediatric respiratory disease in Africa, Asia, Australia, Europe, and North America. Molecular dating indicates that these viruses have been circulating for at least 250 years. C1 [Briese, Thomas] Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, New York, NY 10032 USA. [Venter, Marietjie; van den Berg, Ria; Koch, Orienka] Univ Pretoria, NHLS Tswhane Acad Div, ZA-0002 Pretoria, South Africa. [Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Ghosh, Dhrubaa; Chadha, Mandeep S.; Mishra, A. C.] Natl Inst Virol, Pune, Maharashtra, India. [Koendgen, Sophie; Ellerbrok, Heinz; Schweiger, Brunhilde; Leendertz, Fabian H.] Robert Koch Inst, D-1000 Berlin, Germany. [Shrestha, Sanjaya K.] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal. [Hoegh, A. Mette; Schonning, Kristian] Hvidovre Univ Hosp, DK-2650 Hvidovre, Denmark. [Casas, Inmaculada] Inst Salud Carlos III, Ctr Nacl Microbiol, Madrid, Spain. [Adjogoua, Edgard Valerie; Akoua-Koffi, Chantal] Inst Pasteur Cote Ivoire, Abidjan, Cote Ivoire. [Williams, David T.; Mackenzie, John S.] Curtin Univ Technol, Perth, WA, Australia. [Chidlow, Glenys; Harnett, Gerry; Smith, David] PathWest Lab, Nedlands, WA, Australia. [Calvo, Cristina] Severo Ochoa Hosp, Madrid, Spain. [Dominguez, Samuel R.; Holmes, Kathryn V.] Univ Colorado, Denver Sch Med, Aurora, CO USA. [Holmes, Edward C.] Penn State Univ, University Pk, PA 16802 USA. [Holmes, Edward C.] NIH, Bethesda, MD 20892 USA. RP Briese, T (reprint author), Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, 722 W 168th St,18th Floor, New York, NY 10032 USA. EM thomas.briese@columbia.edu RI Venter, Marietjie/H-3032-2011; Williams, David/H-6750-2013; Valle, Ruben/A-7512-2013; Palacios, Gustavo/I-7773-2015; Casas, Inmaculada/H-9442-2015; Venter, Marietjie/P-9604-2016; OI Palacios, Gustavo/0000-0001-5062-1938; Casas, Inmaculada/0000-0003-1840-1198; Venter, Marietjie/0000-0003-2696-824X; Holmes, Edward/0000-0001-9596-3552 FU NHLBI NIH HHS [HL083850, R01 HL083850]; NIAID NIH HHS [U54 AI057158, AI051292, AI059576, AI062705, AI57158, P01 AI059576, R01 AI051292, UC1 AI062705] NR 16 TC 70 Z9 71 U1 0 U2 3 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUN PY 2008 VL 14 IS 6 BP 944 EP 947 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 309MR UT WOS:000256465100014 PM 18507910 ER PT J AU Keltz, IK Adelman, L AF Keltz, Ilean K. Adelman, Leonard TI Testing information order effects in a long series of evidence SO EMJ-ENGINEERING MANAGEMENT JOURNAL LA English DT Article DE order effects; long evidence series; evidence coherence; belief revision model ID DECISION-MAKING; BELIEF; JUDGMENT; MODEL; REVISION AB This research investigates order effects in a long evidence series in a decision-making context. The article provides an application to practicing engineering managers, a detailed explanation of the belief revision model, extensions, competing theories, implications, and experimental findings. The belief revision model was tested in a long series context and found a significant recency effect, contrary to model predictions. The results Suggest that the Current belief revision model does not account for sequential manipulations, which affect mental effort. We recommend further investigation into the impact of mental effort and discuss the challenges that engineering managers face when trying to build knowledge to make decisions in information intensive environments. C1 [Keltz, Ilean K.] USA, Washington, DC 20310 USA. [Adelman, Leonard] George Mason Univ, Dept Syst Engn & Operat Res, Fairfax, VA 22030 USA. RP Keltz, IK (reprint author), 9100 Windflower Lane, Annandale, VA 22003 USA. EM ilean.keltz@us.army.mil FU George Mason University's ROTC FX The authors would like to thank Lieutenant Colonel James Overbye and the instructors at George Mason University's ROTC detachment that supported this study. We would also like to acknowledge the third and fourth year ROTC Students at George Mason University who participated in this Study. The views, opinions, and findings contained in this report are those of the authors and should not be construed as an official Department of Defense position, policy, or decision unless so designated by other official documentation. NR 24 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC ENGINEERING MANAGEMENT PI ROLLA PA PO BOX 820, ROLLA, MO 65402 USA SN 1042-9247 J9 EMJ-ENG MANAG J JI EMJ-Eng. Manag. J. PD JUN PY 2008 VL 20 IS 2 BP 22 EP 29 PG 8 WC Engineering, Industrial; Management SC Engineering; Business & Economics GA 340RU UT WOS:000258663500005 ER PT J AU Trainor, TE Brazil, DM Lindberg, T AF Trainor, Timothy E. Brazil, Donna M. Lindberg, Travis TI Building knowledge from organizational experience: Approaches and lessons learned from US army base camp workshops SO EMJ-ENGINEERING MANAGEMENT JOURNAL LA English DT Article DE organizational learning; knowledge management; military base camps AB Capturing, transferring, and building upon knowledge in an organization is a difficult but necessary function to ensure the organization continues to learn and growl This article discusses how a large organization with disparate operating elements can learn from experience. This is illustrated through a case study of the US Army enhancing learning for its organizations involved in developing base camps to Support military forces worldwide. This was done through a series of workshops that led to the creation of a knowledge management system. Knowledge management provides useful methods and tools to improve learning in organizations, which can help facilitate change. The engineering manager can use this article and the lessons learned from our base camp experience as a framework to enhance learning in an organization whose functional elements are varied in terms of mission and location. C1 [Trainor, Timothy E.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Brazil, Donna M.] US Mil Acad, Leadership Program, West Point, NY 10996 USA. RP Trainor, TE (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM timothy.trainor@usma.edu NR 27 TC 5 Z9 5 U1 0 U2 7 PU AMER SOC ENGINEERING MANAGEMENT PI ROLLA PA PO BOX 820, ROLLA, MO 65402 USA SN 1042-9247 J9 EMJ-ENG MANAG J JI EMJ-Eng. Manag. J. PD JUN PY 2008 VL 20 IS 2 BP 37 EP 45 PG 9 WC Engineering, Industrial; Management SC Engineering; Business & Economics GA 340RU UT WOS:000258663500007 ER PT J AU Bazar, MA Quinn, MJ Mozzachio, K Johnson, MS AF Bazar, Mathew A. Quinn, Michael J., Jr. Mozzachio, Kristie Johnson, Mark S. TI Toxicological responses of red-backed salamanders (Plethodon cinereus) to subchronic soil exposures of 2,4,6-trinitrotoluene SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE amphibian; 2,4,6-trinitrotoluene; salamander; toxicity; soil ID TERRESTRIAL SALAMANDER; ORAL TOXICITY; TRINITROTOLUENE; METABOLITES; EXPLOSIVES; ABSORPTION; RATS; DOGS AB Since World War 1, trinitrotoluene (TNT) has been the most commonly used explosive. Environmental contamination associated with synthesis, manufacture of weapons, and use during training exercises has been extensive, with soil concentrations reaching 145,000 mg/kg. Some of these areas include habitats for amphibian species. Earlier studies have shown that salamanders dermally absorb TNT from soil. To ascertain what soil concentrations of TNT are toxic to amphibians, red-backed salamanders (Plethodon cinereus) were exposed to one of five concentrations of TNT in soil for 28 d and evaluated for indicators of toxicity. A total of 100 salamanders were randomly sorted by weight and assigned to target TNT concentrations in soil of either 3,000, 1,500, 750, 325, or 0 mg/kg dry weight. Food consisted of uncontaminated flightless Drosophila melanogaster. Survival was reduced in salamanders exposed to 1,500 and 3,000 mg/kg by 10 and 55%, respectively. Most mortality/morbidity occurred within the first week of exposure. Salamanders had a reduction in hemoglobin at 750 mg/kg or greater and a reduction in red blood cell concentration at 1,500 mg/kg or greater. Food consumption was affected in salamanders at 750 mg/kg or greater; a reduction in body mass and liver glycogen content also occurred at and above this concentration. Splenic congestion also was observed in salamanders from these groups. These data suggest that soil TNT concentrations of 373 +/- 41.0 mg/kg or greater result in reduced body mass, reduced feed intake, and hematological effects. C1 [Bazar, Mathew A.; Quinn, Michael J., Jr.; Johnson, Mark S.] USA, Ctr Hlth Promot & Preventat Med, Directorate Toxicol, Aberdeen Proving Ground, MD 21010 USA. [Mozzachio, Kristie] Biotechnics, Hillsborough, NC 27278 USA. RP Johnson, MS (reprint author), USA, Ctr Hlth Promot & Preventat Med, Directorate Toxicol, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM mark.s.johnson@us.army.mil NR 33 TC 7 Z9 8 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUN PY 2008 VL 27 IS 6 BP 1393 EP 1398 DI 10.1897/07-547.1 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 301OS UT WOS:000255906100020 PM 18481903 ER PT J AU Chinevere, TD Cadarette, BS Goodman, DA Ely, BR Cheuvront, SN Sawka, MN AF Chinevere, Troy D. Cadarette, Bruce S. Goodman, Daniel A. Ely, Brett R. Cheuvront, Samuel N. Sawka, Michael N. TI Efficacy of body ventilation system for reducing strain in warm and hot climates SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ambient air ventilation; convection; evaporation ID HEAT STRAIN; EXERCISE; COMFORT; STRESS AB This study determined whether a torso-vest forced ambient air body ventilation system (BVS) reduced physiological strain during exercise-heat stress. Seven heat-acclimated volunteers attempted nine, 2-h treadmill walks at 200 W m(-2) in three environments, -40 degrees C, 20% rh (HD), 35 degrees C, 75% rh (HW), and 30 degrees C, 50% rh, (WW) wearing the Army Combat Uniform, interceptor body armor (IBA) and Kevlar helmet. Three trials in each environment were BVS turned on (BVSOn), BVS turned off (BVSOff), and no BVS (IBA). In HD, BVSOn significantly lowered core temperature (T-re), heart rate (HR), mean skin temperature (T-sk), mean torso skin temperature (T-torso), thermal sensation (TS), heat storage (S), and physiological strain index (PSI), versus BVSOff and IBA (P < 0.05). For HW (n = 6), analyses were possible only through 60 min. Exercise tolerance time (min) during HW was significantly longer for BVSOn (116 +/- 10 min) versus BVSOff (95 +/- 22 min) and IBA (96 +/- 18 min) (P < 0.05). During HW, BVSOn lowered HR at 60 min versus IBA, T (sk) from 30 to 60 min versus BVSOff and IBA, and PSI from 45 to 60 min versus BVSOff and at 60 min versus IBA (P < 0.05). BVSOn changes in T-re and HR were lower in HD and HW. During WW, BVSOn significantly lowered HR, T-sk, and T-torso versus BVSOff and IBA (P < 0.05) during late exercise. Sweating rates were significantly lower for BVSOn versus BVSOff and IBA in both HD and WW (P < 0.05), but not HW. These results indicate that BVSOn reduces physiological strain in all three environments by a similar amount; however, in hot-dry conditions the BVSOff increases physiological strain. C1 [Chinevere, Troy D.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Chinevere, Troy D.; Cadarette, Bruce S.; Goodman, Daniel A.; Ely, Brett R.; Cheuvront, Samuel N.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01757 USA. RP Chinevere, TD (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM Troy.Chinevere@us.army.mil NR 22 TC 30 Z9 31 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD JUN PY 2008 VL 103 IS 3 BP 307 EP 314 DI 10.1007/s00421-008-0707-9 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 289CK UT WOS:000255032400007 PM 18327605 ER PT J AU Kemmer, TM Novotny, R Ping, IA AF Kemmer, T. M. Novotny, R. Ping, I. Ah TI Iron deficiency and anemia: disparity exists between children in American Samoa and children living within the US SO EUROPEAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE anemia; iron deficiency; American Samoa; disparity; NHANES; healthy people 2010 ID DECLINING PREVALENCE; UNITED-STATES; LOW-INCOME; CHILDHOOD; PROTOPORPHYRIN; NUTRITION; ENOUGH AB Background/Objectives: Healthy People 2010 emphasizes elimination of health disparity and improvements in anemia and iron deficiency (ID). The study purpose was to (1) determine the prevalence of anemia, ID and ID anemia (IDA) in children living in American Samoa and (2) compare the prevalence to that found in children living in the United States. Subjects/Methods: A total of 211 children from American Samoa, aged 1-5 years of age, participated in this cross-sectional study. Prevalence of anemia, ID and IDA were determined and comparison made using data obtained from children living in the United States. Anemia was diagnosed as hemoglobin (Hb) <110.0 g/l, ID as erythrocyte protoporphyrin (EP) >70 mu mol/ mol heme and IDA as Hb <110.0 g/l and EP 470 mmol/ mol heme. Results: Anemia, ID and IDA prevalence was 33, 70 and 33%, respectively. The results of children from the United States were as follows: anemia, 9%; ID, 10% and IDA, 2%. Within American Samoan children, ID is positively associated with being breastfed <6 months (P<0.05) and anemia and IDA with lower household income (P<0.05; P<0.01). Mean Hb was significantly lower (P<0.001) and mean EP was significantly higher (P<0.001) than those within children living in the United States. Conclusion: To meet Healthy People 2010 goals in children aged 1-2 years, the prevalence of ID in children living in American Samoa would need to decrease from 83 to 5% and in children aged 3-5 years from 59 to 1%. It is critical to ensure that populations within the United States and its territories are provided appropriate resources to promote health and prevent disease. C1 [Kemmer, T. M.] Walter Reed Army Med Ctr, Dept Med, Wellness Serv, Washington, DC 20307 USA. [Kemmer, T. M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Novotny, R.] Univ Hawaii, Honolulu, HI 96822 USA. [Ping, I. Ah] Lyndon B Johnson Trop Med Ctr, Dept Dietary Serv, Pago Pago, AS USA. RP Kemmer, TM (reprint author), Walter Reed Army Med Ctr, Dept Med, Wellness Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM terikemmer@yahoo.com NR 25 TC 2 Z9 2 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0954-3007 J9 EUR J CLIN NUTR JI Eur. J. Clin. Nutr. PD JUN PY 2008 VL 62 IS 6 BP 754 EP 760 DI 10.1038/sj.ejcn.1602786 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 308KU UT WOS:000256389600010 PM 17538546 ER PT J AU Pattabiraman, N Ling, Y Vinayaka, CR Luo, C Chambers, C Saxena, A AF Pattabiraman, N. Ling, Y. Vinayaka, C. R. Luo, C. Chambers, C. Saxena, A. TI Design and discovery of potent reactivators of nerve agent-inhibited human acetylcholinesterase SO FEBS JOURNAL LA English DT Meeting Abstract CT Joint Conference of the 33rd FEBS Congress/11th IUBMB Conference CY JUN 28-JUL 03, 2008 CL Athens, GREECE C1 [Pattabiraman, N.; Ling, Y.; Vinayaka, C. R.; Luo, C.; Chambers, C.; Saxena, A.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA. RI Pattabiraman, Nagarjan /A-9347-2011 NR 0 TC 0 Z9 0 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1742-464X J9 FEBS J JI FEBS J. PD JUN PY 2008 VL 275 SU 1 BP 174 EP 174 PG 1 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 311XI UT WOS:000256633300541 ER PT J AU Mendis, C Campbell, K Das, R Yang, D Jett, M AF Mendis, Chanaka Campbell, Katherine Das, Rina Yang, David Jett, Marti TI Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells SO FEBS JOURNAL LA English DT Article DE cross-talk; MK591; pathway interconnectors; signal transduction; staphylococcal enterotoxin B ID TUMOR-NECROSIS-FACTOR; ACTIVATED PROTEIN-KINASE; TOXIC-SHOCK-SYNDROME; MAP KINASE; ENDOTHELIAL-CELLS; PHOSPHORYLATION; STRESS; PROLIFERATION; PHOSPHATASE; CROSSTALK AB Staphylococcal enterotoxin B (SEB) has been the focus of a number of studies due to its ability to promote septic shock and a massive impact on the human immune system. Even though symptoms and pathology associated with SEB is well known, early molecular events that lead to lethality are still poorly understood. Our approach was to utilize SEB induced human peripheral blood mononuclear cells (PBMCs) as a prototype module to further investigate the complexity of signaling cascades that may ultimately lead to lethal shock. Our study revealed the activation of multiple divergent intracellular pathways within minutes of SEB induction including components that interconnect investigated pathways. A series of performed inhibitor studies identified a specific inhibitor of 5-LO (MK591), which has the ability to block JNK, MAPK, p38kinase and 5-LO signaling-cascades and drastically reducing the activity of pro-inflammatory cytokine TNF-alpha. Further evaluation of MK591 utilizing cell proliferation assays in PBMCs, human proximal tubule cells and in vivo studies (monkey) showed a decrease in cell proliferation. The inhibitory effect of MK591 was reconfirmed at a genetic level through the utilization of a set of SEB specific genes. Signaling activities, inhibitor studies, cellular analysis and gene expression analysis in unison illustrated the significance of pathway interconnectors such as 5-LO as well as inhibiting such inter-connectors (using MK591) in SEB induced human PBMCs. C1 [Mendis, Chanaka; Campbell, Katherine] Univ Wisconsin, Dept Chem & Engn Phys, Platteville, WI 53818 USA. [Das, Rina; Jett, Marti] Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD USA. [Yang, David] Georgetown Univ, Dept Chem, Washington, DC 20057 USA. RP Mendis, C (reprint author), Univ Wisconsin, Dept Chem & Engn Phys, 308 Ottensman Hall,1 Univ Plaza, Platteville, WI 53818 USA. EM mendisc@uwplatt.edu RI Yang, David/A-7294-2009 NR 32 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1742-464X J9 FEBS J JI FEBS J. PD JUN PY 2008 VL 275 IS 12 BP 3088 EP 3098 DI 10.1111/j.1742-4658.2008.06462.x PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 304OI UT WOS:000256118400009 PM 18479466 ER PT J AU Levens, ED Skarulis, MC AF Levens, Eric D. Skarulis, Monica C. TI Assessing the role of endometrial alteration among obese patients undergoing assisted reproduction SO FERTILITY AND STERILITY LA English DT Editorial Material ID IN-VITRO FERTILIZATION; C-REACTIVE PROTEIN; BODY-MASS INDEX; SPONTANEOUS-ABORTION; INSULIN-RESISTANCE; RECURRENT MISCARRIAGE; OOCYTE DONATION; ADIPOSE-TISSUE; POTENTIAL ROLE; RISK AB Obesity seems to exert a small but important extraovarian effect that may influence cycle outcome during assisted reproduction. Future investigation should focus on elucidating whether the endometriurn is truly responsible for this deficit, and if it is, determining the mechanisms involved. (Fertil Steril (R) 2008;89:1606-8. (c) 2008 by American Society for Reproductive Medicine.). C1 [Levens, Eric D.] NICHHD, Reprod Biol & Med Branch, CRC, Bethesda, MD 20892 USA. [Skarulis, Monica C.] NIDDK, Clin Endocrinol Branch, Natl Inst Hlth, Bethesda, MD USA. [Levens, Eric D.] Walter Reed Army Med Ctr, Natl Inst Hlth, Natl Naval Med Ctr, Washington, DC 20307 USA. [Levens, Eric D.] Univ Hlth Sci, Uniformed Serv, Washington, DC USA. RP Levens, ED (reprint author), NICHHD, Reprod Biol & Med Branch, CRC, Bldg 10,Room E1-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM levense@mail.nih.gov FU Intramural NIH HHS [Z99 HD999999] NR 24 TC 12 Z9 15 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JUN PY 2008 VL 89 IS 6 BP 1606 EP 1608 DI 10.1016/j.fertnstert.2007.03.079 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 315PT UT WOS:000256892600004 PM 17531230 ER PT J AU Abbott, D Doering, CR Caves, CM Lidar, DM Brandt, HE Hamilton, AR Ferry, DK Gea-Banacloche, J Bezrukov, SM Kish, LB AF Abbott, D. Doering, C. R. Caves, C. M. Lidar, D. M. Brandt, H. E. Hamilton, A. R. Ferry, D. K. Gea-Banacloche, J. Bezrukov, S. M. Kish, L. B. TI Dreams versus reality: Plenary debate session on quantum computing SO FLUCTUATION AND NOISE LETTERS LA English DT Editorial Material C1 [Abbott, D.] Univ Adelaide, Ctr Biomed Engn, Adelaide, SA 5005, Australia. [Abbott, D.] Univ Adelaide, Dept Elect & Elect Engn, Adelaide, SA 5005, Australia. [Doering, C. R.] Univ Michigan, Dept Math, Ann Arbor, MI 48109 USA. [Doering, C. R.] Univ Michigan, Michigan Ctr Theoret Phys, Ann Arbor, MI 48109 USA. [Caves, C. M.] Univ New Mexico, Dept Phys & Astron, Albuquerque, NM 87131 USA. [Lidar, D. M.] Univ Toronto, Dept Chem, Chem Phys Theory Grp, Toronto, ON M5S 3H6, Canada. [Lidar, D. M.] Univ Toronto, Ctr Quantum Informat & Quantum Control, Toronto, ON M5S 3H6, Canada. [Brandt, H. E.] USA, Res Lab, Adelphi, MD 20783 USA. [Hamilton, A. R.] Univ New S Wales, Sch Phys, Ctr Quantum Comp Technol, Sydney, NSW 2052, Australia. [Ferry, D. K.] Arizona State Univ, Dept Elect Engn, Tempe, AZ 85287 USA. [Gea-Banacloche, J.] Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA. [Bezrukov, S. M.] NICHD, NIH, Lab Phys & Struct Biol, Bethesda, MD 20892 USA. [Kish, L. B.] Texas A&M Univ, Dept Elect Engn, College Stn, TX 77843 USA. RP Abbott, D (reprint author), Univ Adelaide, Ctr Biomed Engn, Adelaide, SA 5005, Australia. RI Lidar, Daniel/A-5871-2008; Abbott, Derek/E-8352-2011; Hamilton, Alex/A-5639-2011; Caves, Carlton/K-8167-2014 OI Lidar, Daniel/0000-0002-1671-1515; Abbott, Derek/0000-0002-0945-2674; Hamilton, Alex/0000-0001-7484-3738; Caves, Carlton/0000-0001-8876-1186 NR 0 TC 0 Z9 0 U1 0 U2 4 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0219-4775 J9 FLUCT NOISE LETT JI Fluct. Noise Lett. PD JUN PY 2008 VL 8 IS 2 BP C27 EP C51 DI 10.1142/S0219477508004337 PG 25 WC Mathematics, Interdisciplinary Applications; Physics, Applied SC Mathematics; Physics GA 323KU UT WOS:000257445800001 ER PT J AU Hammamieh, R Jett, M AF Hammamieh, Rasha Jett, Marti TI Potential roles for inhibitors of arachidonic acid metabolism in prevention and treatment of breast cancer SO FUTURE LIPIDOLOGY LA English DT Article DE arachidonic acid; breast cancer; cyclooxygenase; cyclooxygenase inhibitor; lipoxygenase; lipoxygenase inhibitor ID SELECTIVE CYCLOOXYGENASE-2 INHIBITOR; MITOGEN-INDUCIBLE CYCLOOXYGENASE; CARCINOMA CELL-LINE; PROSTATE-CANCER; MAMMARY-TUMOR; DIETARY-FAT; IN-VITRO; ADENOMATOUS-POLYPOSIS; GROWTH-INHIBITION; COX-2 INHIBITORS AB Breast cancer is the second leading cause of female cancer-related deaths between the ages of 40 and 50 years in industrialized nations. The essential fatty acid arachidonic acid is suggested to play an important role in the development of various cancers, including breast cancer. Arachidonic acid can be metabolized by COXs and lipoxygenases resulting in the production of bioactive lipids, known to play a role in tumor development. In this review, we aim to provide a brief summary of our understanding of the roles of these enzymes in breast cancer tumorigenesis and progression and the use of COX and lipoxygenase inhibitors for breast cancer treatment and/or prevention. C1 [Hammamieh, Rasha] Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. [Jett, Marti] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. RP Hammamieh, R (reprint author), Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD 20910 USA. EM rasha.hammamieh1@us.army.mil NR 74 TC 2 Z9 2 U1 1 U2 5 PU FUTURE MEDICINE LTD PI LONDON PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND SN 1746-0875 J9 FUTURE LIPIDOL JI Future Lipidol. PD JUN PY 2008 VL 3 IS 3 BP 265 EP 271 DI 10.2217/17460875.3.3.265 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 306YP UT WOS:000256284700010 ER PT J AU Parker, M AF Parker, Michael TI Building Partnerships with African American and White Churches to Promote a Good Old Age for All SO GENERATIONS-JOURNAL OF THE AMERICAN SOCIETY ON AGING LA English DT Article C1 [Parker, Michael] Univ Alabama, Ctr Mental Hlth & Aging, Sch Social Work, Tuscaloosa, AL 35487 USA. [Parker, Michael] Univ Alabama, Ctr Aging, Div Gerontol & Geriatr Med, Birmingham, AL USA. [Parker, Michael] USA, Washington, DC USA. RP Parker, M (reprint author), Univ Alabama, Ctr Mental Hlth & Aging, Sch Social Work, Tuscaloosa, AL 35487 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC AGING PI SAN FRANCISCO PA 833 MARKET ST, STE 511, SAN FRANCISCO, CA 94103-1824 USA SN 0738-7806 J9 GENERATIONS JI Generations-J. Am. Soc. Aging PD SUM PY 2008 VL 32 IS 2 BP 38 EP 41 PG 4 WC Gerontology SC Geriatrics & Gerontology GA V13AU UT WOS:000207640500009 ER PT J AU Kraemer, WJ Nindl, BC Volek, JS Marx, JO Gotshalk, LA Bush, JA Welsch, JR Vingren, JL Spiering, BA Fragala, MS Hatfield, DL Ho, JY Maresh, CM Mastro, AM Hymer, WC AF Kraemer, William J. Nindl, Bradley C. Volek, Jeff S. Marx, James O. Gotshalk, Lincoln A. Bush, Jill A. Welsch, Jill R. Vingren, Jakob L. Spiering, Barry A. Fragala, Maren S. Hatfield, Disa L. Ho, Jen-Yu Maresh, Carl M. Mastro, Andrea M. Hymer, Wesley C. TI Influence of oral contraceptive use on growth hormone in vivo bioactivity following resistance exercise: Responses of molecular mass variants SO GROWTH HORMONE & IGF RESEARCH LA English DT Article DE birth control; estradiol; reproductive hormones; strength; women ID HEAVY-RESISTANCE; IMMUNOFUNCTIONAL ASSAY; WOMEN; MEN; HETEROGENEITY; FEMALES; RELEASE; PHASE; SERUM AB The purpose was to examine effects of oral contraceptive (OC) use on plasma growth hormone (GH) responses to heavy resistance exercise. Sixty untrained women were placed into one of two groups: currently using OC (Ortho Tri-Cyclen (R)) (n = 25; mean SD: 24.5 +/- 4.2 y, 160.4 +/- 7.1 cm, 64.1 +/- 11.3 kg) or not currently using OC (NOC) (n = 35; 23.6 +/- 4.6 y, 165.9 +/- 6.0 cm, 65.7 +/- 10.3 kg). Participants performed an acute heavy resistance exercise test (AHRET; six sets of 10 repetition squats; 2 min rest between sets) during days 2-4 of the follicular phase (NOC group) or of inactive oral contraceptive intake (OC group). Plasma was obtained before and immediately after AHRET and subsequently fractionated based on apparent molecular weight (>60 kD, 3060 kD. and <30 kD). GH was determined in unfractionated plasma and each plasma fraction using 4 methods: (1) Nichols Institute Diagnostics immunoradiometric assay (Nichols), (2) National Institute of Diabetes and Digestive Kidney Diseases (NIDDK) competitive radioimmunoassay, (3) DSL immunofunctional enzyme-linked immunoabsorbent assay (IFA) and (4) rat tibial line bioassay. GH increased (P < 0.05) in all fractions post-AHRET for the Nichols, NIDDK, and IFA. The OC group displayed higher resting GH for the NIDDK, and higher exercise-induced GH for the IFA, Nichols, and NIDDK in unfractionated plasma and >60 kD subfraction compared to NOC group. No differences were observed for the tibial line bioassay. OC use augmented immunological GH response to AHRET in unfractionated plasma and >60 kD molecular weight subtraction. However, OC use only increased biological activity of GH in one of two bioassays. These data demonstrated that GH concentrations at rest and following exercise are assay-dependent. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Kraemer, William J.; Volek, Jeff S.; Vingren, Jakob L.; Spiering, Barry A.; Fragala, Maren S.; Hatfield, Disa L.; Ho, Jen-Yu; Maresh, Carl M.] Univ Connecticut, Dept Physiol & Neurobiol, Dept Kinesiol, Human Performance Lab, Storrs, CT 06269 USA. [Nindl, Bradley C.] US Army Res, Inst Environm Med Natick, Mil Performance Div, Natick, MA 01760 USA. [Marx, James O.] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA. [Gotshalk, Lincoln A.] Univ Hawaii, Dept Hlth & Phys Educ, Hilo, HI 96720 USA. [Bush, Jill A.] Univ Houston, Dept Hlth & Human Performance, Lab Integrated Physiol, Houston, TX 77204 USA. [Welsch, Jill R.; Mastro, Andrea M.; Hymer, Wesley C.] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA. RP Kraemer, WJ (reprint author), Univ Connecticut, Dept Physiol & Neurobiol, Dept Kinesiol, Human Performance Lab, Storrs, CT 06269 USA. EM william.kraemer@uconn.edu OI Mastro, Andrea/0000-0003-2710-3360 NR 29 TC 7 Z9 7 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1096-6374 J9 GROWTH HORM IGF RES JI Growth Horm. IGF Res. PD JUN PY 2008 VL 18 IS 3 BP 238 EP 244 DI 10.1016/j.ghir.2007.10.001 PG 7 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA 297BM UT WOS:000255591100008 PM 18037316 ER PT J AU Martino, M Rajaram, L Maxwell, GL Clarke-Pearson, D AF Martino, Martin Rajaram, L. Maxwell, G. Larry Clarke-Pearson, Daniel TI Combination prophylaxis for thromboembolism prevention among gynecologic oncology patients perioperatively SO GYNECOLOGIC ONCOLOGY LA English DT Letter ID DEEP VENOUS THROMBOSIS; MAJOR ABDOMINAL-SURGERY; RANDOMIZED TRIAL; POSTOPERATIVE THROMBOEMBOLISM; COMPRESSION STOCKINGS; PNEUMATIC COMPRESSION; PULMONARY-EMBOLISM; COST-EFFECTIVENESS; HEPARIN C1 [Martino, Martin] Penn State Canc Inst, Canc Ctr Lehigh Valley Hosp, Div Gynecol Oncol, Allentown, PA USA. [Rajaram, L.] Univ S Florida, Sch Publ Hlth, Tampa, FL 33620 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Gynecol Dis Ctr, Washington, DC 20307 USA. [Clarke-Pearson, Daniel] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA. RP Martino, M (reprint author), Penn State Canc Inst, Canc Ctr Lehigh Valley Hosp, Div Gynecol Oncol, Allentown, PA USA. EM Martin_A.Martino@lvh.com NR 16 TC 0 Z9 1 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JUN PY 2008 VL 109 IS 3 BP 426 EP 427 DI 10.1016/j.ygyno.2007.12.022 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 315PW UT WOS:000256892900019 PM 18294678 ER PT J AU Orwin, EM AF Orwin, Ethan M. TI Of couscous and control: The Bureau of Muslim soldier affairs and the crisis of French colonialism SO HISTORIAN LA English DT Article C1 [Orwin, Ethan M.] USA, Washington, DC USA. RP Orwin, EM (reprint author), Univ St Andrews, St Andrews KY16 9AJ, Fife, Scotland. NR 16 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0018-2370 J9 HISTORIAN JI Historian PD SUM PY 2008 VL 70 IS 2 BP 263 EP 284 DI 10.1111/j.1540-6563.2008.00211.x PG 22 WC History SC History GA 311WF UT WOS:000256630400003 ER PT J AU Horovitz, SG Fukunaga, M de Zwart, JA van Gelderen, P Fulton, SC Balkin, TJ Duyn, JH AF Horovitz, Silvina G. Fukunaga, Masaki de Zwart, Jacco A. van Gelderen, Peter Fulton, Susan C. Balkin, Thomas J. Duyn, Jeff H. TI Low frequency BOLD fluctuations during resting wakefulness and light sleep: A simultaneous EEG-fMRI study SO HUMAN BRAIN MAPPING LA English DT Article DE fMRI; EEG; sleep; resting state; functional connectivity; low frequency fluctuations; default-mode network; visual cortex ID POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL-BLOOD-FLOW; INDEPENDENT COMPONENT ANALYSIS; EYE-MOVEMENT SLEEP; FUNCTIONAL CONNECTIVITY; HUMAN BRAIN; VISUAL-CORTEX; DEFAULT MODE; ALPHA-RHYTHM; RETICULAR-FORMATION AB Recent blood oxygenation level dependent functional MRI (BOLD fMRI) studies of the human brain have shown that in the absence of external stimuli, activity persists in the form of distinct patterns of temporally correlated signal fluctuations. In this work, we investigated the spontaneous BOLD signal fluctuations during states of reduced consciousness such as drowsiness and sleep. For this purpose, we performed BOLD fMRI on normal subjects during varying levels of consciousness, from resting wakefulness to light (non-slow wave) sleep. Depth of sleep was determined based on concurrently acquired EEG data. During light sleep, significant increases in the fluctuation level of the BOLD signal were observed in several cortical areas, among which visual cortex was the most significant. Correlations among brain regions involved with the default-mode network persisted during light sleep. These results suggest that activity in areas such as the default-mode network and primary sensory cortex, as measured from BOLD fMRI fluctuations, does not require a level of consciousness typical of wakefulness. C1 [Horovitz, Silvina G.; Fukunaga, Masaki; de Zwart, Jacco A.; van Gelderen, Peter; Fulton, Susan C.; Duyn, Jeff H.] NINDS, Adv MRI Sect, LFMI, Natl Inst Hlth, Bethesda, MD 20892 USA. [Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Horovitz, SG (reprint author), 9000 Rockville Pike,Bldg 10,Room B1D722, Bethesda, MD 20814 USA. EM silvina.horovitz@nih.gov RI Duyn, Jozef/F-2483-2010; Fukunaga, Masaki/F-6441-2013 OI Fukunaga, Masaki/0000-0003-1010-2644 FU Intramural NIH HHS NR 70 TC 244 Z9 247 U1 3 U2 28 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1065-9471 J9 HUM BRAIN MAPP JI Hum. Brain Mapp. PD JUN PY 2008 VL 29 IS 6 BP 671 EP 682 DI 10.1002/hbm.20428 PG 12 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 311OM UT WOS:000256609500005 PM 17598166 ER PT J AU McDowell, K Nunez, P Hutchins, S Metcalfe, JS AF McDowell, Kaleb Nunez, Patrick Hutchins, Shaun Metcalfe, Jason S. TI Secure mobility and the autonomous driver SO IEEE TRANSACTIONS ON ROBOTICS LA English DT Article DE indirect vision; military driving; route planning; supervisory control; visual scanning ID VEHICLE TELEOPERATION; COLLABORATIVE CONTROL; AUTOMATION; ROBOT; PERFORMANCE; INTERFACES; SYSTEMS; TOOLS AB Autonomous mobility systems developed for unmanned ground vehicles may have additional benefits by enhancing system performance and reducing demands on operators for manned ground vehicles. This effort examines the potential impact of introducing autonomous mobility to control manned vehicles while operators performed secure mobility. Eleven Soldiers participated in an experimental task requiring concurrent control of a manned and an unmanned Stryker performing a road march, scanning of the local environment for targets, and planning of a reconnaissance route for a third simulated asset. The control of the manned vehicle was varied between autonomous. and manual control and several speed and accuracy variables were examined for each task. Subjective measures of operator workload, stress, and motion sickness were also examined. The results support the potential benefits of incorporating autonomous mobility into manned platforms. In speed-matched conditions, autonomous mobility was associated with decreased manned vehicle mission time, faster operator reaction times to targets, greater instances of multitasking while under motion, and lower subjective operator workload measures than with manual driving. In conclusion, autonomous mobility technologies have the potential to free up resources from the vehicle operator and allow for better operator performance on tasks other than vehicle control. C1 [McDowell, Kaleb] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Nunez, Patrick] USA, Tank Automot Res Dev & Engn Ctr Detroit Arsenal, Warren, MI 48397 USA. [Hutchins, Shaun] Alion Sci & Technol, Boulder, CO 80301 USA. [Metcalfe, Jason S.] DCS Corp, Alexandria, VA 22314 USA. RP McDowell, K (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM kgm8@cornell.edu; patrick.nunez@us.army.mil; shutchins@alionscience.com; jmetcalfe@dcscorp.com RI McDowell, Kaleb/A-3410-2009 NR 39 TC 10 Z9 10 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1552-3098 EI 1941-0468 J9 IEEE T ROBOT JI IEEE Trans. Robot. PD JUN PY 2008 VL 24 IS 3 BP 688 EP 697 DI 10.1109/TRO.2008.924261 PG 10 WC Robotics SC Robotics GA 316RH UT WOS:000256966900015 ER PT J AU Ramadurai, D Norton, E Hale, J Garland, JW Stephenson, LD Stroscio, MA Sivananthan, S Kumar, A AF Ramadurai, D. Norton, E. Hale, J. Garland, J. W. Stephenson, L. D. Stroscio, M. A. Sivananthan, S. Kumar, A. TI Fluorescent resonance energy transfer based detection of biological contaminants through hybrid quantum dot-quencher interactions SO IET NANOBIOTECHNOLOGY LA English DT Article AB A nanoscale sensor employing fluorescent resonance energy transfer interactions between fluorescent quantum dots (QDs) and organic quencher molecules can be used for the multiplexed detection of biological antigens in solution. Detection occurs when the antigens to be detected displace quencher-labelled inactivated (or dead) antigens of the same type attached to QD-antibody complexes through equilibrium reactions. This unquenches the QDs, allowing detection to take place through the observation of photoluminescence in solution or through the fluorescence imaging of unquenched QD complexes trapped on filter surfaces. Multiplexing can be accomplished by using several different sizes of QDs, with each size QD labelled with an antibody for a different antigen, providing the ability to detect several types of antigens or biological contaminants simultaneously in near real-time with high specificity and sensitivity. C1 [Ramadurai, D.; Garland, J. W.; Stroscio, M. A.; Sivananthan, S.] EPIR Technol Inc, Bolingbrook, IL 60440 USA. [Norton, E.; Hale, J.; Stephenson, L. D.; Kumar, A.] USA, Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61822 USA. RP Ramadurai, D (reprint author), EPIR Technol Inc, Bolingbrook, IL 60440 USA. EM rdinakar@epir.com NR 13 TC 3 Z9 4 U1 0 U2 1 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8741 J9 IET NANOBIOTECHNOL JI IET Nanobiotechnol. PD JUN PY 2008 VL 2 IS 2 BP 47 EP 53 DI 10.1049/iet-nbt:20070033 PG 7 WC Biochemical Research Methods; Nanoscience & Nanotechnology SC Biochemistry & Molecular Biology; Science & Technology - Other Topics GA 311TY UT WOS:000256624500003 PM 18500912 ER PT J AU Wortmann, G Weintrob, A Barber, M Scott, P Zoll, ST Eshoo, MW Sampath, R Ecker, DJ Massire, C AF Wortmann, Glenn Weintrob, Amy Barber, Melissa Scott, Paul Zoll, Scott T. Eshoo, Mark W. Sampath, Rangarajan Ecker, David J. Massire, Christian TI Genotypic evolution of Acinetobacter baumannii strains in an outbreak associated with war trauma SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID IDENTIFICATION; INFECTIONS; IRAQ AB The Walter Reed Army Medical Center has experienced an influx of traumatically injured patients either infected or colonized with Acinetobacter baumannii. Using multilocus polymerase chain reaction (PCR) and mass spectrometry to genotype isolates, we found an atypical and evolving strain distribution, distinct from those found at nonmilitary hospitals in the United States. C1 [Wortmann, Glenn; Weintrob, Amy; Barber, Melissa] Walter Reed Army Med Ctr, Infect Dis Clin, Infect Dis Serv, Washington, DC 20307 USA. [Weintrob, Amy; Barber, Melissa] Infect Dis Clin Res Program, Bethesda, MD USA. [Scott, Paul] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. [Zoll, Scott T.; Eshoo, Mark W.; Sampath, Rangarajan; Ecker, David J.; Massire, Christian] Ibis Biosci, Carlsbad, CA USA. RP Wortmann, G (reprint author), Walter Reed Army Med Ctr, Infect Dis Clin, Infect Dis Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM glenn.wortmann@amedd.army.mil NR 7 TC 24 Z9 24 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JUN PY 2008 VL 29 IS 6 BP 553 EP 555 DI 10.1086/588221 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 307JI UT WOS:000256314800013 PM 18510464 ER PT J AU Cook, MB Graubard, BI Rubertone, MV Erickson, RL McGlynn, KA AF Cook, Michael B. Graubard, Barry I. Rubertone, Mark V. Erickson, Ralph L. McGlynn, Katherine A. TI Perinatal factors and the risk of testicular germ cell tumors SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE nonseminoma; perinatal risk factors; seminoma; testicular cancer ID CARCINOMA-IN-SITU; BIRTH-WEIGHT; CANCER INCIDENCE; MALES BORN; YOUNG MEN; TESTIS; COHORT; AGE; CRYPTORCHIDISM; NONSEMINOMA AB Testicular germ cell tumors (TGCT) are the most common cancer among young men in the United States and Western Europe. Prior evidence suggests that TGCT may arise in perinatal life, although few risk factors have yet been identified. To study the etiology of TGCT, the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study enrolled participants and their mothers between 2002 and 2005. Five hundred twenty-seven mothers of cases and 561 mothers of controls provided information on perinatal variables. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95%Cl) associated with the candidate risk factors. Analyses were conducted for all TGCT together and for each histologic subgroup (seminoma and nonseminoma) separately. Young maternal age (<20 vs. 20-29 years, OR = 1.51, 95%Cl: 1.09-2.10), young paternal age (<25 vs. 25-29 years, OR = 1.45, 95%Cl: 1.08-1.94), maternal parity (3 vs. 1, OR = 0.63, 95%Cl: 0.44-0.90) and breech birth (OR = 1.92, 95%Cl: 1.03-3.56) were associated with risk of TGCT. For seminoma, young maternal age (<20 vs. 20-29 years, OR = 1.67, 95%Cl: 1.10-2.54), young paternal age (<25 vs. 25-29 years, OR = 1.53, 95 % Cl: 1.03-2.27), maternal parity (3 vs. 1, OR = 0.58, 95%Cl: 0.35-0.96) and low birth weight (<2,500 g vs. 2,500-4,000 g, OR = 1.82, 95%Cl: 1.00-3.30) were risk factors. Nonseminoma was associated with breech birth (OR = 2.44, 95%Cl: 1.25-4.78) and Cesarean section (OR = 2.10, 95%Cl: 1.25-3.54). These results support the hypothesis that TGCT may originate in very early life. (c) 2008 Wiley-Liss, Inc. C1 [Cook, Michael B.; Graubard, Barry I.; McGlynn, Katherine A.] NCI, NIH, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Cook, MB (reprint author), NCI, NIH, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet,Dept Hlth & Human Serv, EPS-5005,6120 Execut Blvd, Bethesda, MD 20892 USA. EM cookmich@mail.nih.gov RI Cook, Michael/A-5641-2009 OI Cook, Michael/0000-0002-0533-7302 FU Intramural NIH HHS [Z99 CA999999] NR 45 TC 37 Z9 38 U1 0 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0020-7136 J9 INT J CANCER JI Int. J. Cancer PD JUN 1 PY 2008 VL 122 IS 11 BP 2600 EP 2606 DI 10.1002/ijc.23424 PG 7 WC Oncology SC Oncology GA 295HT UT WOS:000255466300027 PM 18324625 ER PT J AU Behner, T Anderson, CE Orphal, DL Hohler, V Moll, M Templeton, DW AF Behner, Th. Anderson, C. E., Jr. Orphal, D. L. Hohler, V. Moll, M. Templeton, D. W. TI Penetration and failure of lead and borosilicate glass against rod impact SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE PbO glass; borosilicate glass; failure wave; penetration velocity; damage velocity ID HIGH-DENSITY GLASS; TAYLOR IMPACT; WAVES; SPEED; STRENGTH; FRACTURE; TARGETS; STRAIN AB This paper presents the experimental design and results for gold rod impact on DEDF (5.19 g/cm(3)) and Borofloat (2.2 g/cm(3)) glass by visualizing simultaneously failure propagation in the glass with a high-speed camera and rod penetration with flash radiography. At a given impact velocity, the velocity of the failure front is significantly higher during early penetration than during steady-state penetration of the rod. For equal pressures but different stress states, the failure front velocities determined from Taylor tests or planar-impact tests are greater than those observed during steady-state rod penetration. The ratio of average failure front velocity to rod penetration velocity decreases with increasing impact velocity (nu(p)) in the range of nu(p) = 0.4-2.8 km/s. As a consequence, the distance between the rod tip and the failure front is reduced with increasing nu(p). The Tate term R(T) increases with impact velocity. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Anderson, C. E., Jr.] SW Res Inst, San Antonio, TX 78228 USA. [Behner, Th.; Hohler, V.; Moll, M.] Ernst Mach Inst, Fraunhofer Inst Kurzzeitdynam, D-79104 Freiburg, Germany. [Orphal, D. L.] Int Res Assoc Inc, Pleasanton, CA 94566 USA. [Templeton, D. W.] USA, RDECOM TARDEC, AMSRD TAR R, Warren, MI 48397 USA. RP Anderson, CE (reprint author), SW Res Inst, 6220 Culebra Rd, San Antonio, TX 78228 USA. EM charles.anderson@swri.org NR 34 TC 33 Z9 33 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD JUN PY 2008 VL 35 IS 6 BP 447 EP 456 DI 10.1016/j.ijimpeng.2007.04.004 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 281CN UT WOS:000254474200002 ER PT J AU Srisurapanon, S Sukwit, S Kulpraneet, M Sumransurp, K Chuenchitra, T Santiwatanakul, S AF Srisurapanon, S. Sukwit, S. Kulpraneet, M. Sumransurp, K. Chuenchitra, T. Santiwatanakul, S. TI Roles of NK and NKT cells in Mycobacterium tuberculosis infection SO INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY LA English DT Meeting Abstract C1 [Srisurapanon, S.; Kulpraneet, M.; Sumransurp, K.; Santiwatanakul, S.] Srinakharinwirot Univ, Fac Med, Bangkok, Thailand. [Sukwit, S.; Chuenchitra, T.] Armed Forces Res Inst Med Sci, Div Res, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1751-5521 J9 INT J LAB HEMATOL JI Int. J. Lab. Hematol. PD JUN PY 2008 VL 30 SU 1 BP 118 EP 118 PG 1 WC Hematology SC Hematology GA 287SX UT WOS:000254937900205 ER PT J AU Lang, J Bliese, PD Lang, JWB Adler, AB AF Lang, Jessica Bliese, Paul D. Lang, Jones W. B. Adler, Amy B. TI Causal directions in the relationship between organizational justice and employee depressive symptoms SO INTERNATIONAL JOURNAL OF PSYCHOLOGY LA English DT Meeting Abstract C1 [Bliese, Paul D.; Adler, Amy B.] US Army, Med Res Unit Europe, Heidelberg, Germany. [Lang, Jones W. B.] Rhein Westfal TH Aachen, Inst Psychol, Aachen, Germany. RI Lang, Jessica/I-2388-2014 OI Lang, Jessica/0000-0001-7802-8546 NR 0 TC 0 Z9 0 U1 0 U2 1 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 0020-7594 J9 INT J PSYCHOL JI Int. J. Psychol. PD JUN-AUG PY 2008 VL 43 IS 3-4 BP 61 EP 61 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 349EO UT WOS:000259264300682 ER PT J AU Brunye, T Taylor, H AF Brunye, Tad Taylor, Holly TI Working memory and spatial descriptions: Insights into mental model form and function SO INTERNATIONAL JOURNAL OF PSYCHOLOGY LA English DT Meeting Abstract C1 [Brunye, Tad] US Army Res Dev & Enginee, Natick, MA USA. [Taylor, Holly] Tufts Univ, Medford, MA 02155 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 0020-7594 J9 INT J PSYCHOL JI Int. J. Psychol. PD JUN-AUG PY 2008 VL 43 IS 3-4 BP 557 EP 557 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 349EO UT WOS:000259264306541 ER PT J AU Bassan, D AF Bassan, David TI Evaluating user interface effects oil situation awareness within the Mission to Means Framework (MMF) approach SO INTERNATIONAL JOURNAL OF PSYCHOLOGY LA English DT Meeting Abstract C1 [Bassan, David] USA, Res Lab, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 0020-7594 J9 INT J PSYCHOL JI Int. J. Psychol. PD JUN-AUG PY 2008 VL 43 IS 3-4 BP 616 EP 616 PG 1 WC Psychology, Multidisciplinary SC Psychology GA 349EO UT WOS:000259264307238 ER PT J AU Carlson, LA Headley, S DeBruin, J Tuckow, AP Koch, AJ Kenefick, RW AF Carlson, Lara A. Headley, Samuel DeBruin, Jason Tuckow, Alex P. Koch, Alexander J. Kenefick, Robert W. TI Carbohydrate supplementation and immune responses after acute exhaustive resistance exercise SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM LA English DT Article DE cortisol; immune function; weight training ID LYMPHOCYTE PROLIFERATIVE RESPONSE; PROLONGED EXERCISE; SUBSET COUNTS; PLASMA; SYSTEM; BLOOD AB This investigation sought to study changes in leukocyte subsets after an acute bout of resistance exercise (ARE) and to determine whether ingestion of carbohydrate (CHO) could attenuate those immune responses. Nine male track-and-field athletes (21.1 +/- 1.4 yr, 177.2 +/- 5.5 cm, 80.9 +/- 9.7 kg, 8.7% +/- 3.8% fat) and 10 male ice hockey athletes (21.0 +/- 2.2 yr, 174.3 +/- 6.2 cm, 79.6 +/- 11.1 kg, 13.9% +/- 3.73% fat) participated in 2 different ARE protocols. Both experiments employed a counterbalanced double-blind research design, wherein participants consumed either a CHO (1 g/kg body weight) or placebo beverage before, during, and after a weight-lifting session. Serum cortisol decreased (p <.05) at 90 min into recovery compared with immediately postexercise. Plasma lactate, total leukocyte, neutrophil, and monocyte concentrations increased (p <. 05) from baseline to immediately postexercise. Lymphocytes decreased significantly (p <.05) from baseline to 90 min postexercise. Lymphocytes were lower (p <.05) for the CHO condition than for placebo. The findings of this study indicate the following: ARE appears to evoke changes in immune cells similar to those previously reported during endurance exercise, and CHO ingestion attenuates lymphocytosis after ARE. C1 [Carlson, Lara A.] Castleton State Coll, Dept Nat Sci, Castleton, VT 05735 USA. [Headley, Samuel; DeBruin, Jason] Springfield Coll, Springfield, MA 01109 USA. [Tuckow, Alex P.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Kenefick, Robert W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Koch, Alexander J.] Truman State Univ, Dept Hlth & Exercise Sci, Kirksville, MO USA. RP Carlson, LA (reprint author), Castleton State Coll, Dept Nat Sci, Castleton, VT 05735 USA. FU NCRR NIH HHS [P20-RR16462] NR 27 TC 7 Z9 8 U1 0 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1526-484X J9 INT J SPORT NUTR EXE JI Int. J. Sport Nutr. Exerc. Metab. PD JUN PY 2008 VL 18 IS 3 BP 247 EP 259 PG 13 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 313SG UT WOS:000256759700002 PM 18562773 ER PT J AU Needham, J Burns, T Gerlinger, T AF Needham, Justin Burns, Travis Gerlinger, Tad TI Catastrophic failure of ceramic-polyethylene bearing total hip arthroplasty SO JOURNAL OF ARTHROPLASTY LA English DT Article DE catastrophic failure; polyethylene wear; ceramic; hip recurrent dislocation ID FOLLOW-UP; ACETABULAR COMPONENT; WEAR; OSTEOLYSIS; HEADS; METAL; LINER; STERILIZATION; ASSOCIATION; REPLACEMENT AB Complications of ceramic-polyethylene bearing total hip arthroplasty (THA) include osteolysis, loosening, dislocation, and component failure. Catastrophic acetabular component failure involves severe damage to both the polyethylene liner and metal shell. This case study presents the first reported complete wear-through of the acetabular portion of a ceramic-polyethylene arthroplasty presenting as a dislocation and a review of the literature. In this study, a patient's alumina ceramic femoral head penetrated the polyethylene liner and titanium shell and presented as a dislocated THA. The contributing factors for this catastrophic failure include young patient age, high activity level, thin polyethylene liner, backside wear, component positioning, polyethylene sterilization with gamma irradiation in air, and lack of appropriate follow-up. Revision THA was performed without complications. C1 Brooke Army Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. RP Burns, T (reprint author), Brooke Army Med Ctr, Dept Orthopaed Surg, Bldg 3600,3851 Roger Brook Dr, Ft Sam Houston, TX 78234 USA. NR 29 TC 4 Z9 4 U1 0 U2 2 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI PHILADELPHIA PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA SN 0883-5403 J9 J ARTHROPLASTY JI J. Arthroplast. PD JUN PY 2008 VL 23 IS 4 BP 627 EP 630 DI 10.1016/j.arth.2007.04.026 PG 4 WC Orthopedics SC Orthopedics GA 311WX UT WOS:000256632200026 PM 18514888 ER PT J AU Chen, L McKenna, TM Reisner, AT Gribok, A Reifman, J AF Chen, Liangyou McKenna, Thomas M. Reisner, Andrew T. Gribok, Andrei Reifman, Jaques TI Decision tool for the early diagnosis of trauma patient hypovolemia SO JOURNAL OF BIOMEDICAL INFORMATICS LA English DT Article DE linear classifier; ensemble classifier; liemorrhage; hypovolemia; vital-signs; decision assist; monitoring; physiology ID LIFESAVING INTERVENTIONS; VITAL SIGNS; EPIDEMIOLOGY; CLASSIFIERS; PREDICTORS; HEMORRHAGE; DEATHS; FUSION; CURVE; BLUNT AB We present a classifier for use as a decision assist tool to identify a hypovolernic state in trauma patients during helicopter transport to a hospital, when reliable acquisition of vital-sign data may be difficult. The decision tool uses basic vital-sign variables as input into linear classifiers, which are then combined into an ensemble classifier. The classifier identifies hypovolernic patients with an area under a receiver operating characteristic curve (AUC) of 0.76 (standard deviation 0.05, for 100 randomly-reselected patient subsets,). The ensemble classifier is robust; classification performance degrades only slowly as variables are dropped, and the ensemble structure (toes not require identification of a set of variables for use as best-feature inputs into the classifier. The ensemble classifier consistently outperforms bestfeatures-based linear classifiers (the classification AUC is greater, and the standard deviation is smaller, p < 0.05). The simple computational requirements of ensemble classifiers will permit them to function in small fieldable devices for continuous monitoring of trauma patients. (c) 2007 Elsevier Inc. All rights reserved. C1 [Chen, Liangyou; McKenna, Thomas M.; Reisner, Andrew T.; Gribok, Andrei; Reifman, Jaques] USA, MRMC, Telemed & Adv Technol Res Ctr, Frederick, MD 21702 USA. [Reisner, Andrew T.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. [Gribok, Andrei] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37919 USA. RP Reifman, J (reprint author), USA, MRMC, Telemed & Adv Technol Res Ctr, Bldg 363 Miller Dr, Frederick, MD 21702 USA. EM lchen@bioanalysis.org; Thomas.McKenna2@us.army.mil; areisner@partners.org; agribok@bioanalysis.org; jaques.reifman@us.army.mil NR 44 TC 25 Z9 25 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1532-0464 J9 J BIOMED INFORM JI J. Biomed. Inform. PD JUN PY 2008 VL 41 IS 3 BP 469 EP 478 DI 10.1016/j.jbi.2007,12.002 PG 10 WC Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA 318YR UT WOS:000257129200007 PM 18255342 ER PT J AU Manivannan, A Glaspell, G Dutta, P AF Manivannan, A. Glaspell, G. Dutta, P. TI Synthesis of nanocrystalline TiO(2) particles and their structural characteristics SO JOURNAL OF CLUSTER SCIENCE LA English DT Article DE nanoparticles; titania; Raman; ESR ID SOL-GEL SYNTHESIS; TITANIUM-DIOXIDE; OXIDATION; ANATASE; FILMS AB Controlled nanosized TiO(2) particles of 4-10 nm were synthesized by a simple hydrolysis method followed by calcination at different temperatures. These particles were investigated using X-ray diffraction (XRD), Photoacoustic/Fourier transform infrared (PA/FTIR) spectroscopy, Raman spectroscopy and electron spin resonance (ESR) spectroscopy to understand their structural properties. X-ray diffraction studies confirmed the anatase phase of the particles where as the PA/FTIR revealed the bands around 1,500 and 3,300 cm(-1) due to -OH bands. ESR spectroscopic investigations carried out from 5 to 300 K indicated the presence of an ESR line at g = 2.00 emerging from radical species. It is significant to note that the intensity of the ESR line decreased as the particle size increased. C1 [Glaspell, G.] USA, Ctr Res Dev & Engn, Alexandria, VA 22315 USA. [Manivannan, A.; Dutta, P.] W Virginia Univ, Dept Phys, Morgantown, WV 26506 USA. [Glaspell, G.] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. RP Glaspell, G (reprint author), USA, Ctr Res Dev & Engn, Alexandria, VA 22315 USA. EM garry.p.glaspell@erdc.usace.army.mil RI Manivannan, Ayyakkannu/A-2227-2012 OI Manivannan, Ayyakkannu/0000-0003-0676-7918 NR 20 TC 4 Z9 5 U1 0 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1040-7278 J9 J CLUST SCI JI J. Clust. Sci. PD JUN PY 2008 VL 19 IS 2 BP 391 EP 399 DI 10.1007/s10876-008-0181-x PG 9 WC Chemistry, Inorganic & Nuclear SC Chemistry GA 305OF UT WOS:000256187000006 ER PT J AU Jacobs, RN Markunas, J Pellegrino, J Almeida, LA Groenert, M Jaime-Vasquez, M Mahadik, N Andrews, C Qadri, SB AF Jacobs, R. N. Markunas, J. Pellegrino, J. Almeida, L. A. Groenert, M. Jaime-Vasquez, M. Mahadik, N. Andrews, C. Qadri, S. B. TI Role of thermal expansion matching in CdTe heteroepitaxy on highly lattice-mismatched substrates SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE stresses; substrates; molecular beam epitaxy; cadmium compounds; semiconducting II-VI materials; infrared devices ID MOLECULAR-BEAM EPITAXY; CRITICAL THICKNESS; QUALITY; GROWTH; HGCDTE; SURFACE; LAYERS; SI AB We report on the significance of thermal expansion mismatch in the heteroepitaxial growth of CdTe on highly lattice-mismatched substrates. Such substrates including Si, Ge, or GaAs are desirable for CdTe buffer layer growth and subsequent deposition of HgCdTe infrared absorber layers. Besides lattice misfit, the thermal mismatch associated with these systems can produce additional strain and defects at low or elevated temperatures. However, little work has been done towards documenting and understanding these effects. Experimental evidence of thermal-expansion-dependent residual stress is presented for CdTe/Si(211), CdTe/Ge(211), and CdTe/GaAs(211) films based on X-ray diffraction studies. The experimental results are also compared with residual stress calculations based on known material properties. These results may play a vital role in the design and development of HgCdTe detectors for large-format, infrared focal plane arrays (FPA). Published by Elsevier B.V. C1 [Jacobs, R. N.; Markunas, J.; Pellegrino, J.; Almeida, L. A.; Groenert, M.; Jaime-Vasquez, M.] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA. [Mahadik, N.; Andrews, C.; Qadri, S. B.] USN, Res Lab, Washington, DC 20375 USA. RP Jacobs, RN (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil RI Mahadik, Nadeemullah/C-8551-2009 NR 20 TC 24 Z9 24 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD JUN 1 PY 2008 VL 310 IS 12 BP 2960 EP 2965 DI 10.1016/j.jcrysgro.2008.02.029 PG 6 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 317GA UT WOS:000257006800002 ER PT J AU Jones, KA Wood, MC Zheleva, TS Kirchner, KW Derenge, MA Bolonikov, A Sudarshan, TS Vispute, RD Hullavarad, SS Dhar, S AF Jones, K. A. Wood, M. C. Zheleva, T. S. Kirchner, K. W. Derenge, M. A. Bolonikov, A. Sudarshan, T. S. Vispute, R. D. Hullavarad, S. S. Dhar, S. TI Structural and chemical comparison of graphite and BN/AlN caps used for annealing ion implanted SiC SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE silicon carbide; ion implantation; BN; AlN and graphite annealing caps ID 6H SILICON-CARBIDE; SURFACE-MORPHOLOGY; ACTIVATION; ALUMINUM; 4H; AL AB The effectiveness of AlN/BN and graphite annealing caps for ion implanted SiC was examined morphologically, structurally, chemically, and electrically. The AlN/BN cap more effectively blocks the out-diffusion of silicon because it is essentially inert. Relatively small amounts of silicon from the SiC diffuse out into the graphite cap and react with it. This has the effect of lowering the Si vapor pressure so that it does not create blow holes in this relatively weak structure. The graphite cap can be removed easily with an oxygen plasma, while warm KOH has to be used to remove the nitride cap, and not all of it can be removed after an 1800 degrees C anneal. The out-diffusion of silicon through the graphite cap is most severe at 1800 degrees C, where it roughens the SiC surface and forms reaction products when the Si reacts with the graphite at a significant rate. At lower temperatures these reaction products form small particulates on the surface that are visible only at higher magnifications. In those regions where the graphite cap crystallized, isolated morphological damage on the SiC surface was also detected, appearing to be in the vicinity of the grain boundaries. Scratches on the substrate surface were not affected even at temperatures as high as 1800 degrees C. C1 [Jones, K. A.; Wood, M. C.; Zheleva, T. S.; Kirchner, K. W.; Derenge, M. A.; Bolonikov, A.; Sudarshan, T. S.; Vispute, R. D.; Hullavarad, S. S.; Dhar, S.] USA, Sensors & Electron Devices Directorate, Res Lab, AMSRD RL, Adelphi, MD 20783 USA. RP Jones, KA (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, AMSRD RL, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ken.a.jones@us.army.mil NR 18 TC 5 Z9 6 U1 1 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUN PY 2008 VL 37 IS 6 BP 917 EP 924 DI 10.1007/s11664-008-0405-8 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 289MN UT WOS:000255058700018 ER PT J AU Ozkan, S Adrian, DD Sills, GL Singh, VP AF Ozkan, Senda Adrian, Donald D. Sills, George L. Singh, Vijay P. TI Transient head development due to flood induced seepage under levees SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article AB The purpose of this study was to predict the uplift force during floods on confining layers that overlay extensive horizontal confined aquifers that intersect a large river in response to the water level changes that occur with time in a flooding river. Transient flow of water through the confined aquifer was described by a diffusion type of equation with a boundary condition at the river in which the river head varied with time. The transient head distribution developed from the unsteady flow model applied to the aquifer was compared with the hydraulic head distributions obtained from U.S. Army Corps of Engineers steady-state flow model and a finite-element seepage model. This study concluded that the transient flow model has the potential to analyze time lag in head development, and to predict the seepage condition and heaving potential at various times and distances landside of a levee during a flood cycle, but additional case histories are needed to justify widespread use of the model. C1 [Ozkan, Senda] Tetra Tech EC Inc, Bothell, WA 98011 USA. [Adrian, Donald D.] Louisiana State Univ, Baton Rouge, LA 70803 USA. [Sills, George L.] USA Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Singh, Vijay P.] Texas A&M Univ, Dept Biol & Agr Engn, College Stn, TX 77843 USA. RP Ozkan, S (reprint author), Tetra Tech EC Inc, 19803 N Creek Pkwy, Bothell, WA 98011 USA. NR 34 TC 3 Z9 3 U1 0 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD JUN PY 2008 VL 134 IS 6 BP 781 EP 789 DI 10.1061/(ASCE)1090-0241(2008)134:6(781) PG 9 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 302LM UT WOS:000255969800001 ER PT J AU Seager, TP Linkov, I AF Seager, Thomas P. Linkov, Igor TI Coupling multicriteria decision analysis and life cycle assessment for nanomaterials SO JOURNAL OF INDUSTRIAL ECOLOGY LA English DT Editorial Material C1 [Linkov, Igor] USA, Engn Res & Dev Ctr, Brookline, MA 02446 USA. [Seager, Thomas P.] Rochester Inst Technol, Golisano Sustainabil Inst, Rochester, NY 14623 USA. RP Linkov, I (reprint author), USA, Engn Res & Dev Ctr, 83 Winchester St,Suite 1, Brookline, MA 02446 USA. EM Igor.Linkov@usace.army.mil NR 9 TC 27 Z9 27 U1 0 U2 7 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1088-1980 J9 J IND ECOL JI J. Ind. Ecol. PD JUN PY 2008 VL 12 IS 3 BP 282 EP 285 DI 10.1111/j.1530-9290.2008.00048.x PG 4 WC GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY; Engineering, Environmental; Environmental Sciences SC Science & Technology - Other Topics; Engineering; Environmental Sciences & Ecology GA 352VJ UT WOS:000259525200007 ER PT J AU Slim, AM Sanghi, P Shry, EA Castillo-Rojas, L Alvarez, J Hernandez, A Conner, WC Erikson, J Bailey, SR AF Slim, Ahmad M. Sanghi, Pramod Shry, Eric A. Castillo-Rojas, Laudino Alvarez, Jorge Hernandez, Antonio Conner, William C. Erikson, John Bailey, Steven R. TI Transcatheter Cardiac Fistula Repair with the Amplatzer Duct Occluder: A Case Report and Review SO JOURNAL OF INTERVENTIONAL CARDIOLOGY LA English DT Article ID CLOSURE; EMBOLIZATION; ARTERY AB Background: Clinically significant cardiac fistulas occur rarely and traditionally are surgically repaired. We describe the first known case of percutaneous closure of a left ventricular outflow tract (LVOT) to left atrium (LA) fistula formed as the result of aortic valve replacement surgery. Case report: The patient was an 86-Year-old woman with a history of aortic valve replacement who began complaining of shortness of breath 7 years later. Initially she was misdiagnosed as having mitral regurgitation. However, a transesophageal echocardiography (TEE) showed the presence of a 7.5 mm fistula between her LVOT and LA, producing a large regurgitant jet. As she was not a good surgical candidate, she underwent percutaneous closure. An Amplatzer Duct Occluder 9-PDA-006 (10 mm x 8 mm) device was successfully deployed in the fistula using TEE guidance. On follow-up, the patient described marked improvement of her symptoms. Discussion: In the rare case of cardiac fistulas that are deemed high risk for surgical intervention, a percutaneous approach with an occlusive device offers promise in treating these patients. (J Interven Cardiol 2008;21:260-264) C1 [Slim, Ahmad M.] Brooke Army Med Ctr, MCHE MDC, Serv Cardiol, Ft Sam Houston, TX 78234 USA. [Sanghi, Pramod; Alvarez, Jorge; Erikson, John; Bailey, Steven R.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cardiol, San Antonio, TX 78284 USA. [Hernandez, Antonio] Univ Texas Hlth Sci Ctr San Antonio, Dept Anesthesiol, San Antonio, TX 78284 USA. RP Slim, AM (reprint author), Brooke Army Med Ctr, MCHE MDC, Serv Cardiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Ahmad.Slim@us.army.mil NR 11 TC 2 Z9 3 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0896-4327 J9 J INTERV CARDIOL JI J. Interv. Cardiol. PD JUN PY 2008 VL 21 IS 3 BP 260 EP 264 DI 10.1111/j.1540-8183.2007.00325.x PG 5 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 314DY UT WOS:000256790600008 PM 18086134 ER PT J AU Faulkner, LE Panagotopulos, SE Johnson, JD Woollett, LA Hui, DY Witting, SR Maiorano, JN Davidson, WS AF Faulkner, Loren E. Panagotopulos, Stacey E. Johnson, Jacob D. Woollett, Laura A. Hui, David Y. Witting, Scott R. Maiorano, J. Nicholas Davidson, W. Sean TI An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages SO JOURNAL OF LIPID RESEARCH LA English DT Article DE ATP binding cassette transporter A-I; apolipoprotein A-I; cell biology; endocytosis; macrophage; confocal microscopy; protein expression ID APOLIPOPROTEIN-A-I; HIGH-DENSITY-LIPOPROTEIN; CASSETTE TRANSPORTER A1; TANGIER-DISEASE; LIPID EFFLUX; CELLULAR CHOLESTEROL; ENDOTHELIAL-CELLS; ABCA1 TRANSPORTER; HEART-DISEASE; APOA-I AB The ATP binding cassette transporter A-1 (ABCA1) is critical for apolipoprotein-mediated cholesterol efflux, an important mechanism employed by macrophages to avoid becoming lipid-laden foam cells, the hallmark of early atherosclerotic lesions. It has been proposed that lipid-free apolipoprotein A-I (apoA-I) enters the cell and is resecreted as a lipidated particle via a retroendocytosis pathway during ABCA1-mediated cholesterol efflux from macrophages. To determine the functional importance of such a pathway, confocal microscopy was used to characterize the internalization of a fully functional apoA-I cysteine mutant containing a thiol-reactive fluorescent probe in cultured macrophages. ApoA-I was also endogenously labeled with S-35-methionine to quantify cellular uptake and to determine the metabolic fate of the internalized protein. It was found that apoA-I was specifically taken inside macrophages and that a small amount of intact apoA-I was resecreted from the cells. However, a majority of the label that reappeared in the media was degraded. We estimate that the mass of apoA-I retroendocytosed is not sufficient to account for the HDL produced by the cholesterol efflux reaction. Furthermore, we have demonstrated that lipid-free apoA-I-mediated cholesterol efflux from macrophages can be pharmacologically uncoupled from apoA-I internalization into cells. On the basis these findings, we present a model in which the ABCA1-mediated lipid transfer process occurs primarily at the membrane surface in macrophages, but still accounts for the observed specific internalization of apoA-I. C1 [Faulkner, Loren E.; Panagotopulos, Stacey E.; Woollett, Laura A.; Hui, David Y.; Maiorano, J. Nicholas; Davidson, W. Sean] Univ Cincinnati, Dept Pathol & Lab Med, Cincinnati, OH 45237 USA. [Johnson, Jacob D.] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Parasitol, Silver Spring, MD 20910 USA. [Witting, Scott R.] Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46204 USA. [Witting, Scott R.] Purdue Univ, Dept Med & Mol Genet, Indianapolis, IN 46202 USA. RP Davidson, WS (reprint author), Univ Cincinnati, Dept Pathol & Lab Med, Cincinnati, OH 45237 USA. EM Sean.Davidson@UC.edu FU NHLBI NIH HHS [R01 HL062542, R01 HL067093, R01 HL-67093, R01 HL-62542] NR 40 TC 41 Z9 45 U1 0 U2 3 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0022-2275 J9 J LIPID RES JI J. Lipid Res. PD JUN PY 2008 VL 49 IS 6 BP 1322 EP 1332 DI 10.1194/jlr.M800048-JLR200 PG 11 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 305PO UT WOS:000256190500018 PM 18359958 ER PT J AU Sang, BI Yoo, ES Kim, BJ Rittmann, BE AF Sang, Byoung-In Yoo, Eui-Sun Kim, Byung J. Rittmann, Bruce E. TI Effect of carrier size on the performance of a three-phase circulating-bed biofilm reactor for removing toluene in gas stream SO JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Article DE biofilm; circulating-bed; toluene; carrier size; inhibition; oxygen depletion ID BIOTRICKLING FILTERS; AIR; BENZENE; XYLENE; BIOFILTRATION; ELIMINATION; VAPOR AB A series of steady-state and short-term experiments on a three-phase circulating-bed biofilm reactor (CBBR) for removing toluene from gas streams were conducted to investigate the effect of macroporous-carrier size (1-mm cubes versus 4-mm cubes, which have the same total surface area) on CBBR performance. Experimental conditions were identical, except for the carrier size. The CBBR with 1-mm carriers (the 1-mm CBBR) overcame the performance limitation observed with the CBBR with 4-mm carriers (the 4-mm CBBR): oxygen depletion inside the biofilm. The 1-mm CBBR consistently had the superior removal efficiencies of toluene and COD, higher than 93% for all, and the advantage was greatest for the highest toluene loading, 0.12 M/m(2)-day. The 1-mm carriers achieved superior performance by minimizing the negative effects of oxygen depletion, because they had 4.7 to 6.8 times thinner biofilm depths. The 1-mm carriers continued to provide protection from excess biomass detachment and inhibition from toluene. Finally, the 1-mm CBBR achieved volumetric removal capacities up to 300 times greater than demonstrated by other biofilters treating toluene and related volatile hydrocarbons. C1 [Sang, Byoung-In; Yoo, Eui-Sun] Northwestern Univ, Dept Civil & Environm Engn, Evanston, IL 60208 USA. [Sang, Byoung-In] Korea Inst Sci & Technol, Ctr Environm Technol Res, Seoul 136791, South Korea. [Yoo, Eui-Sun] Specialty Construct Ctr 26F 27F, Inst Sci & Technol Policy, Seoul 156010, South Korea. [Kim, Byung J.] US Army Corps Engn, CERL, Champaign, IL 61826 USA. [Rittmann, Bruce E.] Arizona State Univ, Biodesign Inst, Ctr Environm Biotechnol, Tempe, AZ 85287 USA. RP Sang, BI (reprint author), Northwestern Univ, Dept Civil & Environm Engn, 2145 Sheridan Rd, Evanston, IL 60208 USA. EM biosang@kist.re.kr NR 33 TC 0 Z9 0 U1 0 U2 2 PU KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY PI SEOUL PA KOREA SCI TECHNOL CENTER #507, 635-4 YEOGSAM-DONG, KANGNAM-GU, SEOUL 135-703, SOUTH KOREA SN 1017-7825 J9 J MICROBIOL BIOTECHN JI J. Microbiol. Biotechnol. PD JUN PY 2008 VL 18 IS 6 BP 1121 EP 1129 PG 9 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 320CT UT WOS:000257212000019 PM 18600057 ER PT J AU Paranavitana, C Pittman, P Velauthapillai, M DaSilva, L AF Paranavitana, Chrysanthi Pittman, Phillip Velauthapillai, Mahendran DaSilva, Luis TI Temporal cytokine profiling of Francisella tularensis-infected human peripheral blood mononuclear cells SO JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION LA English DT Article DE Cytokines; Francisella tularensis; Immunity, cellular; Macrophages; Tularemia ID ENDOTHELIAL GROWTH-FACTOR; T-CELLS; IN-VITRO; PROINFLAMMATORY CYTOKINES; NEUTROPHIL RECRUITMENT; IL-1 RECEPTOR; IFN-GAMMA; INTERLEUKIN-1; MACROPHAGES; EXPRESSION AB Background and Purpose: Francisella tularensis is an intracellular bacterium known to replicate in monocytes and macrophages and cause tularemia in humans. Because of its infectious nature, F tularensis is considered a biowarfare agent. Early cytokine profiles of Francisella-infected human peripheral blood mononuclear cells were evaluated. Methods: Populations of human peripheral blood mononuclear cells were infected in vitro with F tularensis live vaccine strain at a very low multiplicity of infection of 1: 10 (bacteria:cells). A multiplex bead kit which analyzes 30 cytokines, chemokines and growth factors was utilized to measure secreted cytokines in cell supernatants 1, 4, 8, 16, and 24 h post-infection. Results: Compared with uninfected controls, infected cells showed no increase in cytokine secretion at 1 and 4 h, implying a threshold for activation of immune responses. Starting at 8 h post-infection and continuing through to 24 h, an array of cytokines and growth factors was secreted by the infected cells. Some cytokines not previously associated with Francisella infection in humans were detected at 8 h, including interleukin-17 and interleukin-1 receptor agonist and vascular endothelial growth factor. Conclusions: The cytokine profiles of F tularensis-infected peripheral blood mononuclear cells indicate an intricate pattern of both pro- and anti-inflammatory responses, including early T-cell activation. C1 [Paranavitana, Chrysanthi] Walter Reed Army Inst Res, Dept Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Pittman, Phillip] USA, Med Res Inst Infect Dis, Div Med, Frederick, MD USA. [Velauthapillai, Mahendran] Georgetown Univ, Dept Comp Sci, Washington, DC USA. [DaSilva, Luis] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Frederick, MD USA. RP Paranavitana, C (reprint author), Walter Reed Army Inst Res, Dept Bacterial & Rickettsial Dis, Bldg 503,Room 2N59 503,Robert Grant Ave, Silver Spring, MD 20910 USA. EM chrysanthi.paranavitana@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) of the Department of Defense FX We thank Andrew LaClair for excellent technical assistance in performing enzyme-linked immunosorbent assays. We also thank Dr. Manmohan Ranadive, Mr. Lawrence Korman and Ms. Aimee Reisinger for the help with Human Use protocol, and collection of blood samples. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of the Air Force, or the Department of Defense. This work was supported by a grant to Dr. Chrysanthi Paranavitana from the Defense Threat Reduction Agency (DTRA) of the Department of Defense. NR 36 TC 4 Z9 4 U1 0 U2 0 PU SCIENTIFIC COMMUNICATIONS INT LTD PI TAIPEI PA NO 1, CHANG-TE ST, TAIPEI, 100, TAIWAN SN 1684-1182 J9 J MICROBIOL IMMUNOL JI J. Microbiol. Immunol. Infect. PD JUN PY 2008 VL 41 IS 3 BP 192 EP 199 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 364EI UT WOS:000260318600001 PM 18629413 ER PT J AU Roesel, TR AF Roesel, Thomas R. TI Vitamin D deficiency in Iraq and Afghanistan veterans with chronic musculoskeletal pain SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Letter C1 Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. RP Roesel, TR (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. NR 5 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD JUN PY 2008 VL 50 IS 6 BP 613 EP 614 DI 10.1097/JOM.0b013e31817a834b PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 313LM UT WOS:000256742100003 PM 18545087 ER PT J AU Hsu, CS Closmann, JJ Baus, MR AF Hsu, Christensen S. Closmann, James J. Baus, Mark R. TI Idiopathic unilateral cranial nerve VI palsy: A case report and review of the literature SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID RECTUS MUSCLE TRANSPOSITION; BOTULINUM-TOXIN; PROGNOSIS; STRABISMUS; PARALYSIS; OCULINUM; CHILDREN; PARESIS; ADULTS C1 [Hsu, Christensen S.; Closmann, James J.; Baus, Mark R.] Tripler Army Ctr, Honolulu, HI USA. RP Closmann, JJ (reprint author), Tripler Army Med Ctr, 1 Jarrent White Rd, Honolulu, HI 96859 USA. EM armyjawbreaker@gmail.com NR 25 TC 4 Z9 4 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUN PY 2008 VL 66 IS 6 BP 1282 EP 1286 DI 10.1016/j.jams.2007.04.035 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 306SJ UT WOS:000256267800029 PM 18486798 ER PT J AU Iverson, CA Sutlive, TG Crowell, MS Morrell, RL Perkins, MW Garber, MB Moore, JH Wainner, RS AF Iverson, Christine A. Sutlive, Thomas G. Crowell, Michael S. Morrell, Rebecca L. Perkins, Matthew W. Garber, Matthew B. Moore, Josef H. Wainner, Robert S. TI Lumbopelvic manipulation for the treatment of patients with patellofemoral pain syndrome: Development of a clinical prediction rule SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE anterior knee pain; physical examination; rehabilitation; spinal manipulation ID LOW-BACK-PAIN; ANTERIOR KNEE PAIN; LATERALIS MUSCLE-ACTIVITY; VASTUS MEDIALIS OBLIQUUS; WEIGHT-BEARING KNEE; PHYSICAL-THERAPY; CONTROLLED-TRIAL; SPINE MANIPULATION; QUADRICEPS INHIBITION; CLASSIFYING PATIENTS AB STUDY DESIGN: Prospective cohort/predictive validity study. OBJECTIVE: To determine the predictive validity of selected clinical exam items and to develop a clinical prediction rule (CPR) to determine which patients with patellofemoral pain syndrome (PFPS) have a positive immediate response to lumbopelvic manipulation. BACKGROUND: Quadriceps muscle function in patients with PFPS was recently shown to improve following treatment with lumbopelvic manipulation. No previous study has determined if individuals with PFPS experience symptomatic relief of activity-related pain immediately following this manipulation technique. METHODS AND MEASURES: Fifty subjects (26 male, 24 female; age range, 18-45 years) with PFPS underwent a standardized history and physical examination. After the evaluation, each subject performed 3 typically pain-producing functional activities (squatting, stepping up a 20-cm step, and stepping down a 20-cm step). The pain level perceived during each activity was rated on a numerical pain scale (0 representing no pain and 10 the worst possible pain). Following the assessment, all subjects were treated with a lumbopelvic manipulation, which was immediately followed by retesting the 3 functional activities to determine if there was any change in pain ratings. An immediate overall 50% or greater reduction in pain, or moderate or greater improvement on a global rating of change questionnaire, was considered a treatment success. Likelihood ratios (LRs) were calculated to determine which examination items were most predictive of treatment outcome. RESULTS: Data for 49 subjects were included in the data analysis, of which 22 (45%) had a successful outcome. Five predictor variables were identified. The most powerful predictor of treatment success was a side-to-side difference in hip internal rotation range of motion greater than 14 degrees (+LR, 4.9). It this variable was present, the chance of experiencing a successful outcome with the lumbopelvic manipulation improved from 45% to 80%. CONCLUSION: A CPR was developed to predict an immediate successful response to lumbopelvic manipulation in patients with PFPS. However, in light of a limited sample size and potential omission of meaningful predictor variables, future studies are necessary to validate the CPR. C1 [Iverson, Christine A.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [Sutlive, Thomas G.] USA, Baylor Univ, Doctoral Program Phys Therapy, San Antonio, TX USA. [Crowell, Michael S.] Winn Army Community Hosp, Ft Stewart, GA USA. [Morrell, Rebecca L.] Reynolds Army Community Hosp, Ft Sill, OK USA. [Perkins, Matthew W.] Moncrief Army Community Hosp, Ft Jackson, SC USA. [Garber, Matthew B.] Brooke Army Med Ctr, San Antonio, TX USA. [Moore, Josef H.] USA, Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Wainner, Robert S.] SW Texas State Univ, San Marcos, TX 78666 USA. RP Sutlive, TG (reprint author), USA, Baylor Univ, Doctoral Program Phys Therapy, 3150 Stanley Rd,Room 1303, Ft Sam Houston, TX 78234 USA. EM thomas.sutlive@amedd.army.mil NR 82 TC 40 Z9 40 U1 0 U2 5 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUN PY 2008 VL 38 IS 6 BP 297 EP 308 DI 10.2519/jospt.2008.2669 PG 12 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 311FE UT WOS:000256585300003 PM 18515959 ER PT J AU Iverson, C Sutlive, TG Moore, JH Wainner, RS AF Iverson, ChristineA. Sutlive, Thomas G. Moore, Josef H. Wainner, Robert S. TI Lumbopelvic manipulation for the treatment of patients with patellofemoral pain syndrome: Development of a clinical prediction rule - Response SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material ID HIP STRENGTH; KNEE PAIN; FEMALES; KINEMATICS; THERAPY; JOINT C1 [Iverson, ChristineA.] Blanchfield Army Community Hosp, Ft Campbell, KY USA. [Sutlive, Thomas G.] USA, Baylor Univ, Doctoral Program Phys Therapy, San Antonio, TX USA. [Moore, Josef H.] USA, Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Wainner, Robert S.] SW Texas State Univ, San Marcos, TX 78666 USA. RP Iverson, C (reprint author), Blanchfield Army Community Hosp, Ft Campbell, KY USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUN PY 2008 VL 38 IS 6 BP 311 EP 312 PG 2 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 311FE UT WOS:000256585300005 ER PT J AU Lebeda, FJ Adler, M Erickson, K Chushak, Y AF Lebeda, Frank J. Adler, Michael Erickson, Keith Chushak, Yaroslav TI Onset dynamics of type A botulinum neurotoxin-induced paralysis SO JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS LA English DT Article DE in vitro data; in vivo data; clinical data; toxicodynamics; stimulation-frequency dependence ID TOXIN TYPE-A; NEUROMUSCULAR-JUNCTION; HEAVY-CHAIN; BINDING; TRANSLOCATION; SNAP-25; PROTEIN; MANAGEMENT; OUTBREAK; CLEAVAGE AB Experimental studies have demonstrated that botulinum neurotoxin serotype A (BoNT/A) causes flaccid paralysis by a multi-step mechanism. Following its binding to specific receptors at peripheral cholinergic nerve endings, BoNT/A is internalized by receptor-mediated endocytosis. Subsequently its zinc-dependent catalytic domain translocates into the neuroplasm where it cleaves a vesicle-docking protein, SNAP-25, to block neurally evoked cholinergic neurotransmission. We tested the hypothesis that mathematical models having a minimal number of reactions and reactants can simulate published data concerning the onset of paralysis of skeletal muscles induced by BoNT/A at the isolated rat neuromuscular junction (NMJ) and in other systems. Experimental data from several laboratories were simulated with two different models that were represented by sets of coupled, first-order differential equations. In this study, the 3-step sequential model developed by Simpson (J Pharmacol Exp Ther 212:16-21,1980) was used to estimate upper limits of the times during which anti-toxins and other impermeable inhibitors of BoNT/A can exert an effect. The experimentally determined binding reaction rate was verified to be consistent with published estimates for the rate constants for BoNT/A binding to and dissociating from its receptors. Because this 3-step model was not designed to reproduce temporal changes in paralysis with different toxin concentrations, a new BoNT/A species and rate (k(S) ) were added at the beginning of the reaction sequence to create a 4-step scheme. This unbound initial species is transformed at a rate determined by k (S) to a free species that is capable of binding. By systematically adjusting the values of k(S), the 4-step model simulated the rapid decline in NMJ function (k (S) >= 0.01), the less rapid onset of paralysis in mice following i.m. injections (k (S) = 0.001), and the slow onset of the therapeutic effects of BoNT/A (k (S) < 0.001) in man. This minimal modeling approach was not only verified by simulating experimental results, it helped to quantitatively define the time available for an inhibitor to have some effect (t(inhib)) and the relation between this time and the rate of paralysis onset. The 4-step model predicted that as the rate of paralysis becomes slower, the estimated upper limits of (t(inhib)) for impermeable inhibitors become longer. More generally, this modeling approach may be useful in studying the kinetics of other toxins or viruses that invade host cells by similar mechanisms, e.g., receptor-mediated endocytosis. C1 [Lebeda, Frank J.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Adler, Michael] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Erickson, Keith] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Chushak, Yaroslav] USA, Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD 21702 USA. RP Lebeda, FJ (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM Frank.Lebeda@amedd.army.mil NR 41 TC 10 Z9 10 U1 0 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1567-567X J9 J PHARMACOKINET PHAR JI J. Pharmacokinet. Pharmacodyn. PD JUN PY 2008 VL 35 IS 3 BP 251 EP 267 DI 10.1007/s10928-008-9087-3 PG 17 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 324DA UT WOS:000257496700001 PM 18551355 ER PT J AU McCauley, MB Anderson, DM Johnson, AJ AF McCauley, Matthew B. Anderson, Daniel M. Johnson, Anthony J. TI Posterior chamber Vision Implantable Collamer Lens: Stability and evaluation following traumatic grenade explosion SO JOURNAL OF REFRACTIVE SURGERY LA English DT Article ID PHAKIC INTRAOCULAR LENSES; HIGH MYOPIA; CONTACT-LENS; POSITION AB PURPOSE: To report traumatic injury of a patient implanted with Visian Implantable Collamer (ICL) (STAAR Surgical) lenses. METHODS: A 31-year-old man underwent bilateral implantation of Visian ICLs in 2006. Eight months postoperatively, the patient was serving in a combat zone and sustained blunt and fragmentation injuries from a grenade explosion. He was wearing full battle gear, which included ballistic-tested sunglasses, at the time of the assault. RESULTS: Large intraorbital foreign bodies and globe trauma were identified as a result of the grenade explosion. Visual acuity was unaffected and the phakic intraocular lenses remained stable. CONCLUSIONS: This first report of combat trauma in a patient implanted with bilateral phakic ICLs emphasizes the importance of eye protection. Further study of the stability and cataract formation rates in eyes that sustain blunt trauma after ICL implantation is needed. C1 Brooke Army Med Ctr, Dept Ophthalmol, MCHE SDO, Ft Sam Houston, TX 78234 USA. [Anderson, Daniel M.] Tulane Univ, Sch Med, New Orleans, LA 70112 USA. RP McCauley, MB (reprint author), Brooke Army Med Ctr, Dept Ophthalmol, MCHE SDO, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Matthew.McCauley@AMEDD.ARMY.MIL NR 8 TC 5 Z9 6 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 1081-597X J9 J REFRACT SURG JI J. Refractive Surg. PD JUN PY 2008 VL 24 IS 6 BP 648 EP 651 PG 4 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 312AT UT WOS:000256642200018 PM 18581794 ER PT J AU Gilbert, TW Nieponice, A Spievack, AR Holcomb, CJ Gilbert, S Badylak, SF AF Gilbert, Thomas W. Nieponice, Alex Spievack, Alan R. Holcomb, Col. John Gilbert, Sebastien Badylak, Stephen F. TI Repair of the thoracic wall with an extracellular matrix scaffold in a canine model SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE thoracic wall repair; extracellular matrix scaffold; bone regeneration ID SMALL-INTESTINAL SUBMUCOSA; DOG-MODEL; SURGICAL-TREATMENT; RECONSTRUCTION; CONTAMINATION; MESH; POLYTETRAFLUOROETHYLENE; BIOSCAFFOLD; RESECTION; TISSUE AB Naturally derived extracellular matrix (ECM) scaffolds have been successfully used to promote constructive remodeling of injured or missing tissue in a variety of anatomical locations, including abdominal wall repair. Furthermore, ECM scaffolds have shown the ability to resist infection and adhesion formation. The present study investigated the utility of an ECM scaffold, specifically, porcine urinary bladder matrix (UBM), for repair of a 5 X 5 cm full-thickness lateral thoracic wall defect in a canine model (n = 6) including 5-cm segments of the 6th and 7th rib. The resected portion of the 7th rib was replaced as an interpositional graft along with the UBM scaffold. As a control, a Gore-Tex patch was used to repair the same defect (n = 2). The control animals healed by encapsulation of the Gore-Tex patch by dense collagenous tissue. The remodeled UBM grafts showed the presence of site-specific tissue, including organized fibrous connective tissue, muscle tissue, adipose tissue, and bone. Upon fluoroscopic examination, it was shown that both bony defects were replaced with new calcified bone. In the 6th rib space, new bone bridged the entire span. In the 7th rib space, there was evidence of bone formation between the interpositional graft and the existing bone, as well as de novo formation of organized bone in the shape of the missing rib segment parallel to the interpositional graft. This study shows that a naturally occurring ECM scaffold promotes site-specific constructive remodeling in a large thoracic wall defect. (C) 2008 Elsevier Inc. All rights reserved. C1 [Gilbert, Thomas W.; Nieponice, Alex; Badylak, Stephen F.] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA 15219 USA. [Spievack, Alan R.] ACell Inc, Jessop, MD USA. [Holcomb, Col. John] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Gilbert, Sebastien] Univ Pittsburgh, Med Ctr, Dept Thorac Surg, Pittsburgh, PA 15219 USA. RP Badylak, SF (reprint author), Univ Pittsburgh, McGowan Inst Regenerat Med, 100 Technol Dr,Suite 200, Pittsburgh, PA 15219 USA. EM badylaks@upmc.edu OI Gilbert, Sebastien/0000-0003-4357-9553; Badylak, Stephen/0000-0003-3555-0689 NR 23 TC 33 Z9 33 U1 1 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD JUN 1 PY 2008 VL 147 IS 1 BP 61 EP 67 DI 10.1016/j.jss.2007.04.035 PG 7 WC Surgery SC Surgery GA 298EF UT WOS:000255668500009 PM 17950323 ER PT J AU MacDonald, JA AF MacDonald, Justin A. TI A localization algorithm based on head-related transfer functions SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SOUND LOCALIZATION; MODEL; TIME AB Two sound localization algorithms based on the head-related transfer function were developed. Each of them uses the interaural time delay, interaural level difference, and monaural spectral cues to estimate the location of a sound source. Given that most localization algorithms will be required to function in background noise, the localization performance of one of the algorithms was tested at signal-to-noise ratios (SNRs) from 40 to -40 dB. Stimuli included ten real-world, broadband sounds located at 5 degrees intervals in azimuth and at 0 degrees elevation. Both two- and four-microphone versions of the algorithm were implemented to localize sounds to 5 degrees precision. The two-microphone version of the algorithm exhibited less than 2 degrees mean localization error at SNRs of 20 dB and greater, and the four-microphone version committed approximately 1 degrees mean error at SNRs of 10 dB or greater. Potential enhancements and applications of the algorithm are discussed. (C) 2008 Acoustical Society of America. C1 [MacDonald, Justin A.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP MacDonald, JA (reprint author), New Mexico State Univ, POB 30001,MSC 3452, Las Cruces, NM 88003 USA. EM jmacd@nmsu.edu NR 17 TC 17 Z9 19 U1 0 U2 3 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUN PY 2008 VL 123 IS 6 BP 4290 EP 4296 DI 10.1121/1.2909566 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 313HE UT WOS:000256730900027 PM 18537380 ER PT J AU Leek, MR Molis, MR Kubli, LR Tufts, JB AF Leek, Marjorie R. Molis, Michelle R. Kubli, Lina R. Tufts, Jennifer B. TI Enjoyment of Music by Elderly Hearing-Impaired Listeners SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Auditory-Society CY MAR 20-22, 2005 CL Scottsdale, AZ SP Amer Auditory Soc DE Hearing loss; music ID PERCEPTION; AID; JUDGMENTS AB Background: Anecdotal evidence suggests that hearing loss interferes with the enjoyment of music, although it is not known how widespread this problem currently is. Purpose: To estimate the prevalence of music-listening difficulties among a group of elderly hearing aid wearers. Research Design: Interview. Telephone interviews were conducted with patients who wore hearing aids. Questions regarding several aspects of music listening were included. Study Sample: Sixty-eight hearing-impaired people served as subjects. They had all been seen in the audiology clinic for hearing aid evaluation during the previous year. Data Collection and Analysis: Subjects were asked questions concerning their use of hearing aids, the importance of listening to music in their lives, their habits and practices concerning music, and difficulties they experienced in listening to music. Results: Almost 30% of the respondents reported that their hearing losses affected their enjoyment of music. About half of the respondents indicated that music was either too loud or too soft, although only about one-third reported difficulties with level contrasts within musical pieces. In contrast to a similar survey carried out 20 years ago, there were many fewer complaints about listening to music. This result may be due in large part to improvements in hearing aids, especially with regard to nonlinear compression. Conclusions: Although new hearing aid technologies have somewhat reduced problems of music enjoyment experienced by hearing-impaired people, audiologists should be aware that some 25-30% of patients may have difficulties with listening to music and may require extra attention to minimize those problems. C1 [Leek, Marjorie R.; Molis, Michelle R.; Kubli, Lina R.; Tufts, Jennifer B.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. RP Leek, MR (reprint author), Natl Ctr Rehabilitat Auditory Res, 3710 SW US Vet Hosp Rd, Portland, OR 97207 USA. EM Marjorie.Leek@va.gov NR 15 TC 12 Z9 14 U1 2 U2 4 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD JUN PY 2008 VL 19 IS 6 BP 519 EP 526 DI 10.3766/jaaa.19.6.7 PG 8 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 386IF UT WOS:000261876200007 PM 19253784 ER PT J AU McGraw, TA Turiansky, GW AF McGraw, Timothy A. Turiansky, George W. TI Cutaneous myiasis SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Review ID DERMATOBIA-HOMINIS LARVAE; SCANNING-ELECTRON-MICROSCOPY; WOHLFAHRTIA-VIGIL WALKER; FURUNCULAR MYIASIS; CORDYLOBIA-ANTHROPOPHAGA; TUMBU-FLY; SCREWWORM FLY; WORLD SCREWWORM; HYPEREOSINOPHILIC SYNDROME; COCHLIOMYIA-HOMINIVORAX AB Myiasis is the infestation of living tissue by the larvae of flies in the order Diptera. Cutaneous involvement is the most common type of myiasis. Cutaneous myiasis can be subdivided into furuncular, migratory, and wound myiasis. Each subtype is reviewed with discussion of the larvae involved, presenting signs and symptoms, clinical differential diagnoses, and treatment. Preventive measures are also described. C1 [McGraw, Timothy A.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med, Bethesda, MD 20814 USA. [McGraw, Timothy A.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. [Turiansky, George W.] Uniformed Serv Univ Hlth Sci, Dept Dermatol, Bethesda, MD 20814 USA. [McGraw, Timothy A.] The Pentagon, Pentagon Air Force Flight Med Clin, Washington, DC USA. [Turiansky, George W.] Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. [Turiansky, George W.] The Pentagon, DiLorenzo TRICARE Hlth Clin, Washington, DC USA. RP McGraw, TA (reprint author), USAF, MC, FS, 1760 Air Force Pentagon, Washington, DC 20330 USA. EM timothy.mcgraw@us.af.mil NR 150 TC 48 Z9 54 U1 0 U2 8 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUN PY 2008 VL 58 IS 6 BP 907 EP 926 DI 10.1016/j.jaad.2008.03.014 PG 20 WC Dermatology SC Dermatology GA 303QO UT WOS:000256055800001 PM 18485982 ER PT J AU Forman, SB Ferringer, TC Peckham, SJ Dalton, SR Sasaki, GT Libow, LE Elston, DM AF Forman, Seth B. Ferringer, Tammie C. Peckham, Steven J. Dalton, Scott R. Sasaki, Geoff T. Libow, Lester E. Elston, Dirk M. TI Is superficial spreading melanoma still the most common form of malignant melanoma? SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID NEW-SOUTH-WALES; CUTANEOUS MELANOMA; INVASIVE MELANOMA; CANCER REGISTRY; SKIN-CANCER; EPIDEMIOLOGY; TRENDS; AUSTRALIA; PROGNOSIS; AFRICANS AB Background: Most epidemiological studies suggest that superficial spreading melanoma is the most common histological subtype of malignant melanoma, but past data may not reflect current patterns of sun exposure or other risk factors. Objective: We sought to determine the prevalence of melanoma subtypes among recent specimens in a South Texas dermatopathology practice. Results: Lentigo maligna was the most common subtype of melanoma among the cases studied. Of 771 cases of melanoma reviewed, lentigo maligna and lentigo maligna melanoma accounted for 429 (56%). There were 220 cases of pagetoid (superficial spreading) melanoma (29%). Nodular melanoma with no apparent radial growth phase accounted for 27 cases (4%), and there were 23 cases of acral lentiginous melanoma (3%). The remaining 72 specimens (9%) included cutaneous metastases, spitzoid rnelanoma, melanoma in situ arising within a nevus, nevoid melanoma, desmoplastic melanoma, and patterns that could not be classified. Limitations: Although the dermatopathology practice is located in South Texas, most patients are active duty military, military retirees, and military dependents. The majority currently resides in Texas, but the patients have lived in many locations around the world and traveled extensively. Sun exposure patterns and other risk factors may not reflect those of other populations. We were not able to perform subgroup analysis based on ethnicity or skin type as such data were not typically submitted with the specimens. Conclusion: Our results challenge the notion that pagetoid (superficial spreading) melanoma is the most common subtype of malignant melanoma, at least in patients with extensive sun exposure. Changing patterns of sun exposure or environmental factors may contribute to the changing epidemiology of malignant melanoma. The current prevalence of subtypes of melanoma should be studied in other populations. C1 [Forman, Seth B.; Ferringer, Tammie C.; Elston, Dirk M.] Geisinger Med Ctr, Dept Dermatol, Danville, PA 17821 USA. [Forman, Seth B.; Ferringer, Tammie C.; Elston, Dirk M.] Geisinger Med Ctr, Dept Pathol, Danville, PA 17821 USA. [Peckham, Steven J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Dalton, Scott R.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Libow, Lester E.] S Texas Dermatopathol Lab, San Antonio, TX USA. RP Forman, SB (reprint author), Geisinger Med Ctr, Dept Dermatol, 100 N Acad Dr,MC 14-06, Danville, PA 17821 USA. EM sethbforman@gmail.com NR 35 TC 24 Z9 24 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUN PY 2008 VL 58 IS 6 BP 1013 EP 1020 DI 10.1016/j.jaad.2007.10.650 PG 8 WC Dermatology SC Dermatology GA 303QO UT WOS:000256055800012 PM 18485983 ER PT J AU Crane, NJ McHone, B Hawksworth, J Pearl, JP Denobile, J Tadaki, D Pinto, PA Levin, IW Elster, EA AF Crane, Nicole J. McHone, Ben Hawksworth, Jason Pearl, Jonathan P. Denobile, John Tadaki, Doug Pinto, Peter A. Levin, Ira W. Elster, Eric A. TI Enhanced surgical imaging: Laparoscopic vessel identification and assessment of tissue oxygenation SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID LIVE-DONOR NEPHRECTOMY; MULTIPLE RENAL-ARTERIES; REFLECTANCE SPECTROSCOPY; CORONARY-ANGIOGRAPHY; COLONIC PERFUSION; PATENCY CONTROL; PULSE OXIMETRY; GRAFT PATENCY; FREE FLAPS; SURGERY AB BACKGROUND: Inherent to minimally invasive procedures are loss of tactile feedback and loss of three-dimensional assessment. Tasks such as vessel identification and dissection are not trivial for the inexperienced laparoscopic surgeon. Advanced surgical imaging, such as 3-charge-coupled device (3-CCD) image enhancement, can be used to assist with these more challenging tasks and, in addition, offers a method to noninvasively monitor tissue oxygenation during operations. STUDY DESIGN: In this study, 3-CCD image enhancement is used for identification of vessels in 25 laparoscopic donor and partial nephrectomy patients. The algorithm is then applied to two laparoscopic nephrectomy patients involving multiple renal arteries. We also use the 3-CCD camera to qualitatively monitor renal parenchymal oxygenation during 10 laparoscopic donor nephrectomies (LDNs). RESULTS: The mean region of interest (ROI) intensity Values obtained for the renal artery and vein (68.40 +/- 8.44 and 45.96 +/- 8.65, respectively) are used to calculate a threshold intensity value (59.00) that allows for objective vessel differentiation. In addition, we examined the renal parenchyma during LDNs. Mean ROI intensity values were calculated for the renal parenchyma at two distinct time points: before vessel stapling (nonischemic) and just before extraction from the abdomen (ischemic). The nonischemic mean ROI intensity values are statistically different from the ischemic mean ROI intensity values (p < 0.05), even with short ischemia times. CONCLUSIONS: We have developed a technique, 3-CCD image enhancement, for identification of vasculature and monitoring of parenchymal oxygenation. This technique requires no additional laparoscopic operating room equipment and has real-time video capability. C1 USN, Med Res Ctr, Silver Spring, MD 20910 USA. George Washington Univ, Dept Urol, Washington, DC USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. Univ Hlth Sci, Uniformed Serv Univ, Dept Surg, Bethesda, MD USA. NCI, NIH, Bethesda, MD 20892 USA. NIDDK, Chem Phys Lab, NIH, Bethesda, MD 20892 USA. RP Crane, NJ (reprint author), USN, Med Res Ctr, 503 Grant Ave, Silver Spring, MD 20910 USA. EM eric.elster@nied.navy.mil FU Intramural NIH HHS [Z01 SC006659-25] NR 38 TC 11 Z9 12 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD JUN PY 2008 VL 206 IS 6 BP 1159 EP 1166 DI 10.1016/j.jamcollsurg.2008.01.013 PG 8 WC Surgery SC Surgery GA 310EO UT WOS:000256511900010 PM 18501814 ER PT J AU Mascari, TM Mitchell, MA Rowton, ED Foil, LD AF Mascari, T. M. Mitchell, M. A. Rowton, E. D. Foil, L. D. TI Ivermectin as a rodent feed-through insecticide for control of immature sand flies (Diptera : Psychodidae) SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE sand fly; larval control; ivermectin; feed-through; leishmaniasis ID FIELD; DUNG; PATS AB Ivermectin was evaluated as a potential rodent feed-through for the control of immature stages of Phlebotomus papatasi. The survival of sand fly larvae fed feces of Syrian hamsters (Mesocricetus auratus) that had been fed a diet containing 0, 2, 6, 10, 20, 60, or 100 ppm ivermectin was measured. Sand fly larvae fed the feces of ivermectin-treated hamsters had significantly reduced survival, with 100% mortality of larvae fed feces of hamsters fed a diet containing 20, 60, and 100 ppm ivermectin. The results of this study suggest that a control strategy using rodent baits containing ivermectin to control phlebotomine sand flies may be possible. Because rodent reservoirs and sand fly vectors of Leishmania major live in close association in many parts of the Middle East, the control of transmission of the agent of zoonotic Cutaneous leishmaniasis also may be possible. C1 [Mascari, T. M.; Foil, L. D.] Louisiana State Univ, Ctr Agr, Agr Expt Stn, Dept Entomol, Baton Rouge, LA 70803 USA. [Mitchell, M. A.] Univ Illinois, Coll Vet Med, Dept Vet Clin Med, Urbana, IL 61802 USA. [Rowton, E. D.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RP Mascari, TM (reprint author), Louisiana State Univ, Ctr Agr, Agr Expt Stn, Dept Entomol, 402 Life Sci, Baton Rouge, LA 70803 USA. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 17 TC 17 Z9 17 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 2008 VL 24 IS 2 BP 323 EP 326 DI 10.2987/5678.1 PG 4 WC Entomology SC Entomology GA 316IT UT WOS:000256943600021 PM 18666544 ER PT J AU Pak, JH Lee, JJ AF Pak, Jang Hyuk Lee, Jiin-Jen TI A statistical sediment yield prediction model incorporating the effect of fires and subsequent storm events SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE sediment yield prediction; fire; debris flow; debris basin; alluvial fans; mountain watersheds AB Alluvial fans are continuously being developed for residential, industrial, commercial, and agricultural uses in southern California. Development and alteration of alluvial fans need to consider the possibility of mud and debris flows from upstream mountain watersheds affected by fires. Accurate prediction of sediment yield (or hyper-concentrated sediment yield) is essential for the design, operation, and maintenance of debris basins to safeguard properly the general populace. This paper presents a model for the prediction of sediment yields that result from a combination of fire and subsequent storm events. The watersheds used in this analysis are located in the foothills of the San Gabriel Mountains in southern California. A multiple regression analysis is first utilized to establish a fundamental statistical relationship for sediment yield as a function of relief ratio, drainage area, maximum 1-h rainfall intensity and fire factor using 45 years of data (1938-1983). In addition, a method for multi-sequence sediment yield prediction under fire conditions was developed and calibrated using 17 years of sediment yield, fire, and precipitation data for the period 1984-2000. After calibration, this model was verified by applying it to provide a prediction of the sediment yields for the 2001-2002 fire events in southern California. The findings indicate a strong correlation between the estimated and measured sediment yields. The proposed method for sequence sediment yield prediction following fire events can be a useful tool to schedule cleanout operations for debris basins and to develop an emergency response strategy for the southern California region where plentiful sediment supplies exist and frequent fires occur. C1 [Pak, Jang Hyuk; Lee, Jiin-Jen] USA, Corps Engineers, Inst Water Resources, Hydrol Engn Ctr, Davis, CA 95616 USA. Univ So Calif, Dept Civil & Environm Engn, Los Angeles, CA 90089 USA. RP Pak, JH (reprint author), USA, Corps Engineers, Inst Water Resources, Hydrol Engn Ctr, 609 2nd St, Davis, CA 95616 USA. EM jay.h.pak@usace.army.mil NR 16 TC 9 Z9 9 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1093-474X J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD JUN PY 2008 VL 44 IS 3 BP 689 EP 699 DI 10.1111/j.1752-1688.2008.00199.x PG 11 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 302BY UT WOS:000255945000013 ER PT J AU Shariat, SF Trinh, QD Morey, AF Stage, KH Roehrborn, CG Valiquette, L Karakiewicz, PI AF Shariat, Shahrokh F. Trinh, Quoc-Dien Morey, Allen F. Stage, Key H. Roehrborn, Claus G. Valiquette, Luc Karakiewicz, Pierre I. TI Development of a highly accurate nomogram for prediction of the need for exploration in patients with renal trauma SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE trauma; renal; exploration; nomogram ID PROSTATE-CANCER; PREOPERATIVE NOMOGRAM; INJURIES; NEPHRECTOMY; MANAGEMENT; KIDNEY; GUIDELINES; MODELS; SCALE; RISK AB Background: To develop and validate a nomogram for predicting the need for renal exploration after renal trauma. Methods:. From 1995 through 2004, 419 consecutive patients presented to our institution with traumatic renal injury. All were randomly divided into a development (50%, n = 210) and a split sample validation cohort (50%, n = 209). Logistic regression models were used to develop a nomogram for prediction of the need for renal exploration after renal trauma. Internal (200 bootstrap resamples) and 50% split sample validations were performed. Results: Overall, 89 patients (21.2%) underwent renal exploration, from which 60.7% (54 of 89) underwent nephrectomy and 39.3% (35 of 89) underwent renorrhaphy. Nine percent of patients with grade 11 injury underwent renal exploration, 16% with grade III injuries, 41% with grade IV injuries, and 100% of grade V injuries. The kidney injury scale, the mechanism of injury, the need for transfusion, blood urea nitrogen level, and serum creatinine represented the most informative predictors and were included in the nomogram. The split sample accuracy of the nomogram for prediction of the need for renal exploration was 96.9%. It significantly (p < 0.001) exceeded the accuracy of each of its components including the American Association for the Surgery of Trauma kidney injury scale (87.7%). Conclusion: The nomogram generates highly accurate and reproducible predictions of the probability for renal exploration according to our decision-making. It could help standardize the management of patients with renal trauma (i.e., inclusion criteria for clinical trials) and serves as a proof-of-principle that predictive tools can be applied to the trauma setting. Its use may improve the management of renal trauma patients at institutions with limited trauma experience. C1 [Shariat, Shahrokh F.; Stage, Key H.; Roehrborn, Claus G.] Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA. [Trinh, Quoc-Dien; Valiquette, Luc; Karakiewicz, Pierre I.] Univ Montreal, Canc Prognost & Hlth Outcomes Unit, Montreal, PQ, Canada. [Morey, Allen F.] Brooke Army Med Ctr, Houston, TX USA. RP Shariat, SF (reprint author), Univ Texas SW Med Ctr Dallas, Dept Urol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA. EM shahrokh.shariat@utsouthwestern.edu NR 25 TC 18 Z9 22 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2008 VL 64 IS 6 BP 1451 EP 1458 DI 10.1097/TA.0b013e3181271b77 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 313MG UT WOS:000256744100009 PM 18545108 ER PT J AU Niles, SE McLaughlin, DF Perkins, JG Wade, CE Li, YZ Spinella, PC Holcomb, JB AF Niles, Sarah E. McLaughlin, Daniel F. Perkins, Jeremy G. Wade, Charles E. Li, Yuanzhang Spinella, Philip C. Holcomb, John B. TI Increased mortality associated with the early coagulopathy of trauma in combat casualties SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 66th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 27-29, 2007 CL Las Vegas, NV SP Amer Assoc Surg Trauma DE coagulopathy; early coagulopathy; combat casualties ID FRESH-FROZEN PLASMA; REQUIRING MASSIVE TRANSFUSION; DAMAGE CONTROL RESUSCITATION; MAJOR TRAUMA; FLUID RESUSCITATION; BLOOD-PRODUCTS; FACTOR VIIA; HYPOTHERMIA; PREDICTORS; HEMORRHAGE AB Background: Recent civilian studies have documented a relationship between increased mortality and the presence of an early coagulopathy of trauma diagnosed in the emergency department (ED). We hypothesized that acute coagulopathy (international normalized ratio >= 1.5) in combat casualties was associated with increased injury severity and mortality as is seen in civilian trauma patients. Methods: A retrospective study of combat casualties who received a blood transfusion at a single combat support hospital between September 2003 and December 2004 was performed. Coagulation status, pH, base deficit, and temperature were recorded at arrival to the ED. These were analyzed by Injury Severity Score (ISS), associated injury patterns, and mortality. Results:. A total of 3,287 patients were treated at the combat support hospital during the study period. Of these, 391 patients were transfused and primarily admitted, thus meeting the study criteria, 347 had coagulation data, and 92% had a penetrating mechanism. The prevalence of acute coagulopathy in transfused casualties measured with point-of-care devices at arrival in the ED was 38%. Mortality in those who were coagulopathic at arrival to the ED was 24% (32/133) versus 4% (8/214) in those not presenting with coagulopathy (p < 0.001). The prevalence of mortality by coagulopathy increased as ISS increased. Coagulopathy and acidosis were associated with mortality, odds ratio (OR), 5.38 [95% confidence interval (CI), 1.55-11.37] and 6.9 (95% CI, 2.1-19.5), respectively. Temperature did not affect outcomes (OR, 1.1; 95% CI, 0.4-2.6). Conclusions: The early coagulopathy of trauma was rapidly diagnosed in the ED and present in more than one-third of combat casualties who received a transfusion, similar to the incidence found in civilian trauma patients. Coagulopathy, independent of hypothermia but strongly correlated with acidosis and ISS, was associated with mortality in combat casualties, similar to that found in civilian trauma patients. Early diagnosis and treatment of acute traumatic coagulopathy with new resuscitation paradigms may improve outcomes. C1 [Niles, Sarah E.] USA MEDDAC Bavaria, Vilseck, Germany. [McLaughlin, Daniel F.; Wade, Charles E.; Spinella, Philip C.; Holcomb, John B.] USA, Inst Surg Res, San Antonio, TX USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Silver Spring, MD USA. [Spinella, Philip C.] Connecticut Childrens Med Ctr, Dept Pediat, Hartford, CT USA. [Li, Yuanzhang] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Niles, SE (reprint author), 7015 Beyer Rd, Rhinelander, WI 54501 USA. EM sarah.niles@amedd.army.mil OI Li, Yuanzhang/0000-0001-8872-4430 NR 31 TC 175 Z9 195 U1 0 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2008 VL 64 IS 6 BP 1459 EP 1463 DI 10.1097/TA.0b13e318174e8bc PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 313MG UT WOS:000256744100010 PM 18545109 ER PT J AU Adler, AB Litz, BT Castro, CA Suvak, M Thomas, JL Burrell, L McGurk, D Wright, KM Bliese, PD AF Adler, Amy B. Litz, Brett T. Castro, Carl Andrew Suvak, Michael Thomas, Jeffrey L. Burrell, Lolita McGurk, Dennis Wright, Kathleen M. Bliese, Paul D. TI A group randomized trial of critical incident stress debriefing provided to US peacekeepers SO JOURNAL OF TRAUMATIC STRESS LA English DT Article; Proceedings Paper CT 20th Annual Meeting of the International-Society-for-Traumatic-Stress-Studies CY NOV 14-18, 2004 CL New Orleans, LA SP Int Soc Traumat Stress Studies ID PERCEIVED ORGANIZATIONAL SUPPORT; TRAUMA; PERFORMANCE; VICTIMS AB In a group randomized trial of critical incident stress debriefing (CISD) with platoons of 952 peacekeepers, CISD was compared with a stress management class (SMC) and survey-only (SO) condition. Multilevel growth curve modeling found that CISD did not differentially hasten recovery compared to the other two conditions. For those soldiers reporting the highest degree of exposure to mission stressors, CYSD was minimally associated with lower reports of posttraumatic stress and aggression (vs. SMC), higher perceived organizational support (vs. SO), and more alcohol problems than SMC and SO. Soldiers reported that they liked CISD more than the SMC, and CYSD did not cause undue distress. C1 [Adler, Amy B.; Wright, Kathleen M.; Bliese, Paul D.] USA, Med Res Unit Europe, Heidelberg, Germany. [Castro, Carl Andrew; Thomas, Jeffrey L.; Burrell, Lolita; McGurk, Dennis] Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD USA. [Litz, Brett T.; Suvak, Michael] Boston Univ, VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA 02215 USA. [Litz, Brett T.; Suvak, Michael] Boston Univ, Dept Psychol, Boston, MA 02215 USA. RP Adler, AB (reprint author), USA, Med Res Unit, APO, AE 09042 USA. EM amy.adler@us.army.mil NR 33 TC 32 Z9 35 U1 2 U2 13 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUN PY 2008 VL 21 IS 3 BP 253 EP 263 DI 10.1002/jts.20342 PG 11 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 317SF UT WOS:000257039300001 PM 18553407 ER PT J AU Terhakopian, A Sinaii, N Engel, CC Schnurr, PP Hoge, CW AF Terhakopian, Artin Sinaii, Ninet Engel, Charles C. Schnurr, Paula P. Hoge, Charles W. TI Estimating population prevalence of posttraumatic stress disorder: An example using the PTSD Checklist SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID NATIONAL COMORBIDITY SURVEY; MENTAL-HEALTH PROBLEMS; DSM-IV DISORDERS; PRIMARY-CARE; PSYCHOMETRIC PROPERTIES; SCREENING INSTRUMENT; GENDER-DIFFERENCES; SURVEY REPLICATION; CIVILIAN VERSION; FEMALE VETERANS AB The PTSD Checklist (PCL) is among the most widely used self-report instruments for assessing PTSD. To determine PCL performance on a population level, the authors combined data from published studies that compared the PCL with structured diagnostic interviews. Weighted average sensitivities and specificities were calculated for cutoff categories most often reported in the literature. Weighted average sensitivity decreased from .85 to .39 and specificity increased from .73 to .97 for cutoffs ranging from 30 to 60. The PCL's ability to accurately estimate PTSD prevalence varied as a function of cutoff and true PTSD prevalence. In populations with a true PTSD prevalence of 15% or less, cutoff values below 44 will substantially overestimate PTSD prevalence. Uncalibrated use of the PCL for prevalence estimation may lead to large errors. C1 [Hoge, Charles W.] USA, Med Res & Mat Command, Walter Reed Army Inst Res, Div Psychiat & Neuroscience, Silver Spring, MD USA. [Terhakopian, Artin; Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stree, Bethesda, MD 20814 USA. [Sinaii, Ninet] NIH, Ctr Clin, Biostat & Clin Epidemiol Serv, Bethesda, MD 20892 USA. [Schnurr, Paula P.] VA Med Ctr, Natl Ctr PTSD, White River Jct, VT USA. RP Hoge, CW (reprint author), USA, Med Res & Mat Command, Walter Reed Army Inst Res, Div Psychiat & Neuroscience, 503 Robert Grant Ave, Silver Spring, MD USA. EM charles.hoge@us.army.mil NR 47 TC 104 Z9 105 U1 2 U2 8 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUN PY 2008 VL 21 IS 3 BP 290 EP 300 DI 10.1002/jts.20341 PG 11 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 317SF UT WOS:000257039300005 PM 18553416 ER PT J AU Adler, AB Wright, KM Bliese, PD Eckford, R Hoge, CW AF Adler, Amy B. Wright, Kathleen M. Bliese, Paul D. Eckford, Rachel Hoge, Charles W. TI A2 diagnostic criterion for combat-related posttraumatic stress disorder SO JOURNAL OF TRAUMATIC STRESS LA English DT Article; Proceedings Paper CT 114th Annual Convention of the American-Psychological-Association CY AUG 10-13, 2006 CL New Orleans, LA SP Amer Psychol Assoc ID DSM-IV; PSYCHOLOGICAL TRAUMA; VIOLENT CRIME; PRIMARY-CARE; VICTIMS; SYMPTOMATOLOGY; PREVALENCE; VALIDATION; SYMPTOMS; VETERANS AB Individuals trained to respond to a potentially traumatic event may not experience the posttraumatic stress disorder (PTSD) A2 diagnostic criterion of fear helplessness, or horror and yet may still report significant PTSD symptoms. The present study included interviews with 202 soldiers returning from a year in Iraq. Although reporting an A2 response was associated with higher PTSD Checklist scores, there were no significant differences in the percentage of subjects who met cutoff criteria for PTSD. The most common alternative A2 responses were related to military training and anger. The A2 criterion for PTSD should be expanded so as not to underestimate the number of individuals trained for high-risk occupations who might benefit from treatment. C1 [Adler, Amy B.; Wright, Kathleen M.; Bliese, Paul D.; Eckford, Rachel] USA, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. [Hoge, Charles W.] Walter Reed Army Inst Res, Div Psychiat & Neuroscience, Silver Spring, MD USA. RP Adler, AB (reprint author), CMR 442, Box 761, APO, AE 09042 USA. EM amy.adler@us.army.mil NR 31 TC 47 Z9 47 U1 1 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUN PY 2008 VL 21 IS 3 BP 301 EP 308 DI 10.1002/jts.20336 PG 8 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 317SF UT WOS:000257039300006 PM 18553417 ER PT J AU Sames, WJ Kim, HC Chong, ST Harrison, BA Lee, WJ Rueda, LA Klein, TA AF Sames, William J. Kim, Heung Chul Chong, Sung Tae Harrison, Bruce A. Lee, Won-Ja Rueda, Leopoldo A. Klein, Terry A. TI Anopheles lindesayi japonicus Yamada (Diptera : Culicidae) in Korea: comprehensive review, new collection records, and description of larval habitats SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Korea; mosquito; Anopheles; lindesayi; japonicus; distribution AB Anopheles lindesayi japonicus Yamada is an uncommonly collected mosquito in Korea, and its presence is based upon limited collection data and anecdotal reports in Korean mosquito literature: 45 specimens collected from 15 identified sites. This study reports the collection of 538 specimens from 16 sites as part of the authors' 2004-2007 anopheline surveillance. Larvae were collected from stream margins, stream pools, rock pools, seepage springs, artificial containers, swamps, and ditches and were found in association with seven other culicid species. Inclusion of the authors' data with previous published and unpublished records makes this a comprehensive report on this species in Korea. New province records are reported for this species at Hwacheon and Wonju in Gangwon Province, Mt. Palgong in Daegu Metropolitan, and Chungju and Mt. Worak in Chungcheongbuk Province in the Republic of Korea. C1 [Sames, William J.] 18th Med Command, Unit 15281, APO, AP 96205 USA. [Kim, Heung Chul; Chong, Sung Tae] 18th Med Command, Unit 15247, Med Detachment 5, Med Battal AS 168, APO, AP 96205 USA. [Harrison, Bruce A.] N Carolina Dept Environm & Nat Resources, Winston Salem, NC 27107 USA. [Lee, Won-Ja] Korea Ctr Dis Control & Prevent, Seoul 122701, South Korea. [Rueda, Leopoldo A.] Walter Reed Army Inst Res, Div Entomol, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA. RP Sames, WJ (reprint author), Def Logist Agcy, 8725 John J Kingman Rd,ATTN DES E, Ft Belvoir, VA 22060 USA. NR 31 TC 4 Z9 4 U1 0 U2 0 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2008 VL 33 IS 1 BP 99 EP 106 DI 10.3376/1081-1710(2008)33[99:ALJYDC]2.0.CO;2 PG 8 WC Entomology SC Entomology GA 325MD UT WOS:000257592100012 PM 18697312 ER PT J AU Blow, JA Mores, CN Dyer, J Dohm, DJ AF Blow, Jamie A. Mores, Christopher N. Dyer, Jessie Dohm, David J. TI Viral nucleic acid stabilization by RNA extraction reagent SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE arbovirus; RNA stabilization; inactivation; reagents ID VALLEY FEVER VIRUS; DENGUE VIRUS; PCR TAQMAN; SPECIMENS; STABILITY AB In the collection of field materials to test for the presence of arboviruses, samples must be appropriately maintained to detect arboviral nucleic acids. In austere field conditions this is often difficult to achieve because, during routine specimen processing, storage, and shipping viral RNA degradation could result in detection failure. RNA extraction reagents, while used commonly for their intended purpose of stabilizing RNA during the extraction process, have not been assessed fully for their potential to stabilize RNA before extraction. The potential for virus stabilization at varying temperatures and periods of time remains unknown. Accordingly, the ability of buffer AVL (Qiagen, Valencia, CA), an RNA extraction reagent, to stabilize viral suspensions of dengue, Venezuelan equine encephalitis and Rift Valley fever viruses was evaluated. The ability of buffer AVL to stabilize each viral suspension was examined at 32, 20, 4, and -20 degrees C. RNA in samples placed in buffer AVL was stable for at least 48 h at 32 degrees C and refrigerating samples prolonged stabilization. Additionally, placing the samplelbuffer AVL mixture at either 4 or -20 degrees C stabilized samples for at least 35 days. When combined with the ability of buffer AVL to inactivate viral samples, this provides the ability to collect and handle potentially infectious samples in a safe way that also provides sample stabilization. (C) 2008 Elsevier B.V. All rights reserved. C1 [Blow, Jamie A.; Mores, Christopher N.; Dyer, Jessie; Dohm, David J.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Mores, CN (reprint author), Louisiana State Univ, Sch Vet Med, Dept Pathobiol Sci, Skip Bertman Dr, Baton Rouge, LA 70803 USA. EM cmores@lsu.edu NR 14 TC 13 Z9 13 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD JUN PY 2008 VL 150 IS 1-2 BP 41 EP 44 DI 10.1016/j.jviromet.2008.02.003 PG 4 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 305DL UT WOS:000256157900007 PM 18387678 ER PT J AU Jarman, RG Holmes, EC Rodpradit, P Klungthong, C Gibbons, RV Nisalak, A Rothman, AL Libraty, DH Ennis, FA Mammen, MP Endy, TP AF Jarman, Richard G. Holmes, Edward C. Rodpradit, Prinyada Klungthong, Chonticha Gibbons, Robert V. Nisalak, Ananda Rothman, Alan L. Libraty, Daniel H. Ennis, Francis A. Mammen, Mammen P., Jr. Endy, Timothy P. TI Microevolution of dengue viruses circulating among primary school children in Kamphaeng Phet, Thailand SO JOURNAL OF VIROLOGY LA English DT Article ID CELL-CULTURES; IDENTIFICATION; INFECTION; SELECTION; EVOLUTION; TYPE-2 AB To determine the extent and structure of genetic variation in dengue viruses (DENV) on a restricted spatial and temporal scale, we sequenced the E (envelope) genes of DENY-1, -2, and -3 isolates collected in 2001 from children enrolled in a prospective school-based study in Kamphaeng Phet, Thailand, and diagnosed with dengue disease. Our analysis revealed substantial viral genetic variation in both time and space, with multiple viral lineages circulating within individual schools, suggesting the frequent gene flow of DENV into this microenvironment. More-detailed analyses of DENV-2 samples revealed strong clustering of viral isolates within individual schools and evidence of more-frequent viral gene flow among schools closely related in space. Conversely, we observed little evolutionary change in those viral isolates sampled over multiple time points within individual schools, indicating a low rate of mutation fixation. These results suggest that frequent viral migration into Kamphaeng Phet, coupled with population (school) subdivision, shapes the genetic diversity of DENV on a local scale, more so than in situ evolution within school catchment areas. C1 [Jarman, Richard G.] USAMC, Dept Virol, AFRIMS, APO, AP 96546 USA. [Holmes, Edward C.] Penn State Univ, Ctr Infect Dis Dynam, Dept Biol, Mueller Lab, University Pk, PA 16802 USA. [Holmes, Edward C.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. [Rothman, Alan L.; Libraty, Daniel H.; Ennis, Francis A.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA. [Endy, Timothy P.] SUNY Upstate Med Univ, Syracuse, NY 13210 USA. [Jarman, Richard G.; Rodpradit, Prinyada; Klungthong, Chonticha; Gibbons, Robert V.; Nisalak, Ananda; Mammen, Mammen P., Jr.] USAMC, Dept Virol, Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Jarman, RG (reprint author), USAMC, Dept Virol, AFRIMS, APO, AP 96546 USA. EM Richard.Jarman@afrims.org OI Holmes, Edward/0000-0001-9596-3552 FU NIAID NIH HHS [P01 AI034533, P01-AI34533] NR 22 TC 36 Z9 36 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUN PY 2008 VL 82 IS 11 BP 5494 EP 5500 DI 10.1128/JVI.02728-07 PG 7 WC Virology SC Virology GA 301FN UT WOS:000255881900037 PM 18367520 ER PT J AU Geisbert, TW Daddario-DiCaprio, KM Williams, KJN Geisbert, JB Leung, A Feldmann, F Hensley, LE Feldmann, H Jones, SM AF Geisbert, Thomas W. Daddario-DiCaprio, Kathleen M. Williams, Kinola J. N. Geisbert, Joan B. Leung, Anders Feldmann, Friederike Hensley, Lisa E. Feldmann, Heinz Jones, Steven M. TI Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates SO JOURNAL OF VIROLOGY LA English DT Article ID GUINEA-PIGS; INFECTION; VACCINE; CHALLENGE; STRAINS; MONKEYS; LIVE AB Recombinant vesicular stomatitis virus (VSV) vectors expressing homologous filoviral glycoproteins can completely protect rhesus monkeys against Marburg virus when administered after exposure and can partially protect macaques after challenge with Zaire ebolavirus. Here, we administered a VSV vector expressing the Sudan ebolavirus (SEBOV) glycoprotein to four rhesus macaques shortly after exposure to SEBOV. All four animals survived SEBOV challenge, while a control animal that received a nonspecific vector developed fulminant SEBOV hemorrhagic fever and succumbed. This is the first demonstration of complete postexposure protection against an Ebola virus in nonhuman primates and provides further evidence that postexposure vaccination may have utility in treating exposures to filoviruses. C1 [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Geisbert, Thomas W.; Geisbert, Joan B.] Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA. [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA. [Daddario-DiCaprio, Kathleen M.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. [Williams, Kinola J. N.; Jones, Steven M.] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada. [Feldmann, Heinz; Jones, Steven M.] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada. [Leung, Anders; Feldmann, Friederike; Feldmann, Heinz; Jones, Steven M.] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB, Canada. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Dept Microbiol, 715 Albany St,R514, Boston, MA 02118 USA. EM geisbert@bu.edu NR 22 TC 81 Z9 88 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUN PY 2008 VL 82 IS 11 BP 5664 EP 5668 DI 10.1128/JVI.00456-08 PG 5 WC Virology SC Virology GA 301FN UT WOS:000255881900056 PM 18385248 ER PT J AU Carroll, JF Benante, JP Klun, JA White, CE Debboun, M Pound, JM Dheranetra, W AF Carroll, J. F. Benante, J. P. Klun, J. A. White, C. E. Debboun, M. Pound, J. M. Dheranetra, W. TI Twelve-hour duration testing of cream formulations of three repellents against Amblyomma americanum SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE lone star tick; (1S,2'S) 2-methylpiperidinyl-3-cyclohexene-1-carboxamide; 1-methyl-propyl-2-(hydroxyethyl)-1-piperidinecarboxylate,N,N-diethyl-3-m ethylbenzamide; Picaridin ID PERSONAL PROTECTION; IXODES-SCAPULARIS; FIELD-EVALUATION; TICKS ACARI; HEBRAEUM ACARI; AEDES-AEGYPTI; IXODIDAE; DEET; PERMETHRIN; EFFICACY AB The repellent efficacies of the U.S. military repellent 33% N,N-diethyl-3-methylbenzamide (deet), 10% and 20% (1S, 2'S) 2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) and 10% and 20% 1-methyl-propyl-2-(hydroxyethyl)-1-piperidinecarboxylate (Bayrepel) cream formulations on human volunteers against the lone star tick Amblyomma americanum (L.) were evaluated in a simulated forest floor environment over a 12-h testing period. At 2-h intervals, volunteers, with repellent applied in a 5-cm-wide band around each ankle, stood for 5 min in plastic tubs containing leaf litter and 100 host-seeking A. americanum nymphs. Ticks were allowed to remain on a volunteer's feet and ankles for an additional 5 min after the volunteer exited the tub. All repellent formulations provided high levels of protection for the entire 12 h. No ticks crossed 5-cm-wide bands of 20% SS220 and Bayrepel during any challenge, and thus 100% protection was afforded throughout the test. These formulations showed a long-lasting efficacy hitherto unknown in tick repellents intended for use on human skin. C1 [Carroll, J. F.] ARS, Anim Parasit Dis Lab, USDA, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA. [Benante, J. P.; Dheranetra, W.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Klun, J. A.] ARS, Invas Insect Behav & Biocontrol Lab, USDA, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA. [White, C. E.] Walter Reed Army Inst Res, Div Med AV, Lib & Stat Serv, Silver Spring, MD USA. [Debboun, M.] USA, Med Zool Branch, Dept Prevent Hlth Serv, Acad Hlth Sci,Med Dept Ctr & Sch, Ft Sam Houston, TX USA. [Pound, J. M.] ARS, Knipling Bushland US Livestock Insects Res Lab, USDA, Kerrville, TX USA. RP Carroll, JF (reprint author), ARS, Anim Parasit Dis Lab, USDA, BARC E, Bldg 1040, Beltsville, MD 20705 USA. EM john.carroll@ars.barc.usda.gov NR 29 TC 25 Z9 25 U1 3 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD JUN PY 2008 VL 22 IS 2 BP 144 EP 151 DI 10.1111/j.1365-2915.2008.00721.x PG 8 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 304VY UT WOS:000256138400007 PM 18498614 ER PT J AU Spiering, BA Kraemer, WJ Anderson, JM Armstrong, LE Nindl, BC Volek, JS Judelson, DA Joseph, M Vingren, JL Hatfield, DL Fragala, MS Ho, JY Maresh, CM AF Spiering, Barry A. Kraemer, William J. Anderson, Jeffrey M. Armstrong, Lawrence E. Nindl, Bradley C. Volek, Jeff S. Judelson, Daniel A. Joseph, Michael Vingren, Jakob L. Hatfield, Disa L. Fragala, Maren S. Ho, Jen-Yu Maresh, Carl M. TI Effects of elevated circulating hormones on resistance exercise-induced Akt signaling SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE endocrine; mTOR; pkb; muscle signaling ID HUMAN SKELETAL-MUSCLE; PROTEIN-SYNTHESIS; MAMMALIAN TARGET; GROWTH-HORMONE; TRANSLATIONAL CONTROL; MECHANICAL STIMULI; MESSENGER-RNA; AMINO-ACIDS; IGF-I; PHOSPHORYLATION AB Purpose: Hormones and muscle contraction alter protein kinase B (Akt) signaling via distinct mechanisms. Therefore, the purpose of this study was to determine whether physiologically elevated circulating hormones modulate resistance exercise (RE)-induced signaling of Akt and its downstream targets. We hypothesized that elevated circulating hormones would potentiate the signaling response. Methods: Seven healthy men (mean +/- SD age, 27 +/- 4 yr; body mass, 79.1 +/- 13.6 kg; body fat, 16%+/- 7%) performed two identical lower-body RE protocols (five sets of five maximal repetitions of knee extensions) in a randomized order and separated by 1-3 wk: one protocol was preceded by rest [low-circulating hormonal concentration (LHC) trial], and the other was preceded by a bout of high-volume upper-body RE using short rest periods designed to elicit a large increase in circulating hormones [high-circulating hormonal concentration (HHC) trial]. Results: The HHC trial invoked significantly (P <= 0.05) greater growth hormone (GH) and cortisol concentrations compared with the LHC trial. There were minimal differences between trials in insulin and insulin-like growth factor-I (IGF-I) concentrations. Contrary to our hypothesis, 70-kDa ribosomal protein S6 kinase (p70 S6K) threonine (Thr) 389 phosphorylation within the vastus lateralis was attenuated at 180 min post-RE during the HHC trial. RE did not affect Akt or glycogen synthase kinase-3 beta (GSK-3 beta) phosphorylation nor were there differences between trials. Immediately post-RE, eukaryotic initiation factor (eIF) 4E binding protein-1 (4E-BP1) phosphorylation declined, and adenosine monophosphate-activated protein kinase (AMPK) phosphorylation increased; however, there were no differences between trials in these variables. Conclusion: p70 S6K Thr 389 phosphorylation was attenuated during the HHC trial despite dramatically greater (> 2.5-fold) circulating GH concentrations; this was potentially due to cortisol-induced inhibition of p70 S6K Thr 389 phosphorylation. C1 [Spiering, Barry A.; Kraemer, William J.; Anderson, Jeffrey M.; Armstrong, Lawrence E.; Volek, Jeff S.; Joseph, Michael; Vingren, Jakob L.; Hatfield, Disa L.; Fragala, Maren S.; Ho, Jen-Yu; Maresh, Carl M.] Univ Connecticut, Dept Kinesiol, Human Performance Lab, Storrs, CT 06269 USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Judelson, Daniel A.] Calif State Univ Fullerton, Dept Kinesiol, Fullerton, CA 92634 USA. RP Kraemer, WJ (reprint author), Univ Connecticut, Dept Kinesiol, Human Performance Lab, Storrs, CT 06269 USA. EM William.Kraemer@uconn.edu NR 40 TC 23 Z9 23 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUN PY 2008 VL 40 IS 6 BP 1039 EP 1048 DI 10.1249/MSS.0b013e31816722bd PG 10 WC Sport Sciences SC Sport Sciences GA 305DH UT WOS:000256157500008 PM 18461003 ER PT J AU Arciero, PJ Gentile, CL Pressman, R Everett, M Ormsbee, MJ Martin, J Santamore, J Gorman, L Fehling, PC Vukovich, MD Nindl, BC AF Arciero, Paul J. Gentile, Christopher L. Pressman, Roger Everett, Meghan Ormsbee, Michael J. Martin, Jeff Santamore, Jason Gorman, Liza Fehling, Patricia C. Vukovich, Matthew D. Nindl, Bradley C. TI Moderate protein intake improves total and regional body composition and insulin sensitivity in overweight adults SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article ID LOW-CARBOHYDRATE-DIET; OBESE HYPERINSULINEMIC SUBJECTS; WEIGHT-LOSS; GLUCOSE-TOLERANCE; SHORT-TERM; LOW-FAT; RESISTANCE EXERCISE; ENERGY-EXPENDITURE; PHYSICAL-ACTIVITY; AFRICAN-AMERICAN AB A high protein intake (similar to 40% of energy intake) combined with aerobic and resistance exercise training is more closely associated with improved body composition and cardiovascular risk profile than a traditional protein intake (similar to 15% of intake) combined with moderate-intensity aerobic exercise. However, there is concern that such high-protein diets may adversely affect health. We therefore tested the hypothesis that moderate protein intake (similar to 25% of energy intake) would elicit similar benefits on body composition and metabolic profile as high protein intake. Twenty-four overweight/obese men and women (body mass index [BMI] = 32.2 +/- 3.4, percentage of body fat [%BF] = 37.3 +/- 8.0) were matched for BMI and %BF and randomly assigned to one of 3 groups for a 3-month nutrition/exercise training intervention: (1) high-protein diet (similar to 40% of energy intake) and combined high-intensity resistance and cardiovascular training (HPEx, n = 8, 5 female and 3 male), (2) moderate-protein diet (similar to 25% of energy intake) and combined high-intensity resistance and cardiovascular training (MPEx, n = 8, 5 female and 3 male), or (3) high-protein diet only (HPNx, n = 8, 5 female and 3 male). Total and regional body composition (dual-energy x-ray absorptiometry), insulin sensitivity (insulin sensitivity index to the oral glucose tolerance test), insulin-like growth factor-1 (IGF-1), IGF binding protein-1 (IGFBP-1), IGF binding protein-3 (IGFBP-3), and blood lipids were measured at baseline and after the intervention. All groups experienced significant (P<.05) and similar losses of body weight, BMI, and total and abdominal %BF, and similar improvements in insulin sensitivity (HPEx, 6.3 +/- 1.2.vs 9.5 +/- 0.98; MPEx, 6.2 +/- 1.4 vs 8.4 +/- 1.6; HPNx, 3.7 +/- 1.1 vs 7.0 +/- 1.1; insulin sensitivity index to the oral glucose tolerance test; P<.05) and leptin levels. Furthermore, the HPEx group demonstrated decreases in total cholesterol (TC) and triglycerides, and increases in IGF-1 and IGFBP-1. The MPEx group experienced decreases in TC, whereas the HPNx group had increases in high-density lipoprotein cholesterol, TC to high-density lipoprotein, IGF-1, and IGFBP-1. In conclusion, moderate protein intake elicits similar benefits in body composition and insulin sensitivity as a high-protein diet. These findings may have practical implications for individuals interested in diets containing elevated dietary protein. (C) 2008 Elsevier Inc. All rights reserved. C1 [Arciero, Paul J.; Pressman, Roger; Everett, Meghan; Ormsbee, Michael J.; Martin, Jeff; Santamore, Jason; Gorman, Liza; Fehling, Patricia C.] Skidmore Coll, Dept Exercise Sci, Saratoga Springs, NY 12866 USA. [Gentile, Christopher L.] Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA. [Vukovich, Matthew D.] S Dakota State Univ, Dept Hlth Phys Educ & Recreat, Pierre, SD 57501 USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Div Mil Performance, Washington, DC USA. RP Arciero, PJ (reprint author), Skidmore Coll, Dept Exercise Sci, Saratoga Springs, NY 12866 USA. EM parciero@skidmore.edu NR 41 TC 24 Z9 25 U1 1 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 J9 METABOLISM JI Metab.-Clin. Exp. PD JUN PY 2008 VL 57 IS 6 BP 757 EP 765 DI 10.1016/j.metabol.2008.01.015 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 312BF UT WOS:000256643400005 PM 18502257 ER PT J AU Yang, Y Gupta, MC Zalameda, JN Winfree, WP AF Yang, Y. Gupta, M. C. Zalameda, J. N. Winfree, W. P. TI Dispersion behaviour, thermal and electrical conductivities of carbon nanotube-polystyrene nanocomposites SO MICRO & NANO LETTERS LA English DT Article ID POLYMER COMPOSITES; MECHANICAL-PROPERTIES; EPOXY COMPOSITES; MORPHOLOGY AB The dispersion behaviour, thermal and electrical conductivities of carbon nanotube-polystyrene nanocomposites were investigated. The dispersion of carbon nanotubes ( CNTs) in the nanocomposites was characterised by scanning electron microscope; it was observed that CNTs were homogeneously dispersed and embedded within the polystyrene matrix. The thermal conductivity of the nanocomposites were measured with a through transmission thermal inspection system at room temperature. The results showed that the thermal conductivity increased with an increase in CNT content, and the nanocomposite loaded 5 wt% CNTs exhibited a 120% enhancement in thermal conductivity. The correlation between the dispersion behaviour and thermal and electrical conductivities was discussed. In addition, it was demonstrated that CNT-polymer nanocomposites give larger increases in thermal and electrical conductivities for the same loading of carbon nanofibres, graphite powders and silver nanoparticles. C1 [Yang, Y.; Gupta, M. C.] Univ Virginia, Charles L Brown Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. [Zalameda, J. N.] USA, Res Lab, NASA Langley Res Ctr, Nondestruct Evaluat Sci Branch, Hampton, VA 23681 USA. [Winfree, W. P.] NASA, Langley Res Ctr, Nondestruct Evaluat Sci Branch, Hampton, VA 23681 USA. RP Yang, Y (reprint author), Univ Virginia, Charles L Brown Dept Elect & Comp Engn, Charlottesville, VA 22904 USA. EM yonglaiyang@hotmail.com NR 25 TC 26 Z9 27 U1 1 U2 25 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1750-0443 J9 MICRO NANO LETT JI Micro Nano Lett. PD JUN PY 2008 VL 3 IS 2 BP 35 EP 40 DI 10.1049/mnl:20070073 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 320PX UT WOS:000257248600001 ER PT J AU Zuhur, S Abunimah, A Malka, H Telhami, S AF Zuhur, Sherifa Abunimah, Ali Malka, Haim Telhami, Shibley TI Hamas and the two-state solution: Villain, victim or missing ingredient? SO MIDDLE EAST POLICY LA English DT Editorial Material C1 [Zuhur, Sherifa] USA, War Coll, Strateg Studies Inst, Washington, DC 20310 USA. [Telhami, Shibley] Univ Maryland, College Pk, MD 20742 USA. RP Zuhur, S (reprint author), USA, War Coll, Strateg Studies Inst, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1061-1924 J9 MIDDLE EAST POLICY JI Middle East Policy PD SUM PY 2008 VL 15 IS 2 BP 1 EP 30 DI 10.1111/j.1475-4967.2008.00346.x PG 30 WC Area Studies; International Relations SC Area Studies; International Relations GA 306JF UT WOS:000256243400001 ER PT J AU Niebuhr, DW Scott, CT Powers, TE Li, YZ Han, WW Millikan, AM Krauss, MR AF Niebuhr, David W. Scott, Christine T. Powers, Timothy E. Li, Yuanzhang Han, Weiwei Millikan, Amy M. Krauss, Margot R. TI Assessment of recruit motivation and strength study: Preaccession physical fitness assessment predicts early attrition SO MILITARY MEDICINE LA English DT Article ID HARVARD STEP TEST; MILITARY; DISCHARGES; INJURIES; FAILURE; ADAPT AB Background: The Assessment of Recruit Motivation and Strength (ARMS) study was designed to pilot-test the use of a physical fitness screening tool for Army applicants before basic training. Methods: The ARMS test consists of two components, namely, a 5-minute step test and push-ups. Attrition among 7,612 recruits who underwent preaccession ARMS testing and began service between May 2004 and December 2005 was studied. Results: ARMS test performance was found to be significantly related to risk of attrition within 180 days; the hazard ratios for failing relative to passing the ARMS test were 2.27 (95% confidence interval, 1.70-3.04) among female subjects and 1.36 (95% confidence interval, 1.13-1.64) among male subjects. The attributable risk of attrition associated with failing the ARMS test was similar to 40% among female subjects and similar to 30% among male subjects. Discussion: The ARMS study is the first prospective study conducted in the U.S. Army to assess physical fitness before accession. Physical fitness and motivation to serve were shown to correlate with attrition during initial entry training. C1 [Niebuhr, David W.; Scott, Christine T.; Powers, Timothy E.; Li, Yuanzhang; Han, Weiwei; Millikan, Amy M.; Krauss, Margot R.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. RI Niebuhr, David/B-7865-2011; OI Li, Yuanzhang/0000-0001-8872-4430 NR 30 TC 29 Z9 29 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2008 VL 173 IS 6 BP 555 EP 562 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 313AQ UT WOS:000256713900009 PM 18595419 ER PT J AU Stamper, DH Jones, RS Thompson, JC AF Stamper, David H. Jones, Robert S. Thompson, Jennifer C. TI Simulation in health care provider education at Brooke Army Medical Center SO MILITARY MEDICINE LA English DT Article AB The teaching and assessment of clinical skills are critical components of health care provider education, and clinical skill proficiency is essential for safe and successful health care delivery. Medical simulation is being increasingly recognized in health care education as an extremely valuable mechanism for training and assessing clinical skills. As in other high-stakes professions, the use of simulation can enhance the proficiency and efficiency of training while maximizing safety and minimizing risk. Located within Brooke Army Medical Center, the Trauma Simulation Training Center is a multifaceted, full-service, medical simulation facility. In an effort to improve and to expand the role of simulation, we collected data on utilization of the facility and the level of overall satisfaction among our users. Results showed that the primary users were graduate medical education physicians-in-training. In addition, survey results demonstrated that users favored simulation-based learning because of the realism of simulated scenarios. The Trauma Simulation Training Center embraces the simulation-based medical education philosophy by actively inviting training program participation, and we realize that more research is needed to determine the effectiveness of this teaching and assessment modality. C1 [Stamper, David H.; Jones, Robert S.; Thompson, Jennifer C.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Stamper, DH (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 8 TC 7 Z9 7 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2008 VL 173 IS 6 BP 583 EP 587 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 313AQ UT WOS:000256713900013 PM 18595423 ER PT J AU Gaitonde, DY Kepchar, J Sartori, R Sarkar, M AF Gaitonde, David Y. Kepchar, Jessica Sartori, Roberto Sarkar, Martin TI Painless thyroiditis presenting as apathetic hyperthyroidism in a young male SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Meeting of the Army Chapter of the American-College-of-Physicians, Endocrine Breakout Session CY NOV 15-18, 2006 CL Crystal City, VA SP Amer Coll Phys, Army Chapter ID THYROTOXICOSIS AB Apathetic hyperthyroidism is an uncommon presentation of thyrotoxicosis that is most commonly observed in elderly individuals. A small number of cases, however, have been observed in young adults-all of whom were female. We describe a case of apathetic hyperthyroidism due to painless thyroiditis in a 23-year-old active duty male, who presented with a I-month history of change in behavior characterized by poverty of speech and disinterest in his surrounding environment. Initial evaluation for neuropsychological disorders was negative. Thyroid function tests showed a thyrotoxic state. Results of thyroid antibody testing and a thyroid uptake and scan supported the diagnosis of painless thyroiditis. The patient's presenting symptoms were attributed to apathetic thyrotoxicosis and he was treated supportively. His speech and social involvement slowly improved. Although uncommon in young adults, we recommend that apathetic hyperthyroidism be considered in the differential diagnosis of withdrawn social behavior and subsequently investigated with thyroid function tests. C1 [Gaitonde, David Y.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. [Kepchar, Jessica] Philadelphia Coll Osteopath Med, Philadelphia, PA 19131 USA. [Sartori, Roberto] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Sarkar, Martin] Munson Army Hlth Ctr, Ft Leavenworth, KS 66027 USA. RP Gaitonde, DY (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM david.gaitonde@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2008 VL 173 IS 6 BP 609 EP 611 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 313AQ UT WOS:000256713900018 PM 18595428 ER PT J AU Lou, JD Lu, XL Marrogi, AJ Li, F Gao, CL Yu, XP AF Lou, Ji-Dong Lu, Xiu L. Marrogi, Aizen J. Li, Feng Gao, Chun-Ling Yu, Xiaoping TI A first example of a reaction under viscous conditions: oxidation of solid benzoins with manganese dioxide SO MONATSHEFTE FUR CHEMIE LA English DT Article DE viscous conditions; solid substrate; solvent-free reactions; oxidation; solid benzoins ID BENZILS; ALCOHOLS AB A new, general, and efficient technique for the reaction of solid substrates under viscous conditions with shaking at room temperature is described, which can overcome some of the problems existing in common solvent-free reactions solids as the starting materials. In this manuscript we present as a first example of this method the oxidation of solid benzoins into the corresponding benzils using an environmentally friendly and inexpensive oxidant, manganese dioxide. C1 [Lou, Ji-Dong; Lu, Xiu L.; Yu, Xiaoping] China Inst Metrol, Coll Life Sci, Hangzhou 310018, Zhejiang, Peoples R China. [Marrogi, Aizen J.] Walter Reed Army Med Ctr, Dept Pathol & Area Lab Med, Washington, DC 20307 USA. [Li, Feng] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia. [Gao, Chun-Ling] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. RP Lou, JD (reprint author), China Inst Metrol, Coll Life Sci, Hangzhou 310018, Zhejiang, Peoples R China. EM lou@cjlu.edu.cn RI Li, Feng/H-4099-2011 NR 18 TC 15 Z9 15 U1 0 U2 0 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0026-9247 J9 MONATSH CHEM JI Mon. Chem. PD JUN PY 2008 VL 139 IS 6 BP 609 EP 611 DI 10.1007/s00706-007-0800-5 PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 307ND UT WOS:000256324700006 ER PT J AU Linkov, I Satterstrom, FK Corey, LM AF Linkov, Igor Satterstrom, F. Kyle Corey, Lisa M. TI Nanotoxicology and nanomedicine: making hard decisions SO NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE LA English DT Article DE Nanotoxicology; Risk assessment; Multicriteria decision analysis ID CARBON-NANOTUBES; RISK-ASSESSMENT; TOXICOLOGY AB Current nanomaterial research is focused on the medical applications of nanotechnology, whereas side effects associated with nanotechnology use, especially the environmental impacts, are not taken into consideration during the engineering process. Nanomedical users and developers are faced with the challenge of balancing the medical and societal benefits and risks associated with nanotechnology. The adequacy of available tools, such as physiologically-based pharmacokinetic modeling or predictive structure-activity relationships, in assessing the toxicity and risk associated with specific nanomaterials is unknown. Successful development of future nanomedical devices and pharmaceuticals thus requires a consolidated information base to select the optimal nanomaterial in a given situation-understanding the toxicology and potential side effects associated with candidate materials for medical applications, understanding product life cycle, and communicating effectively with personnel, stakeholders, and regulators. This can be achieved through an innovative combination of toxicology, risk assessment modeling, and tools developed in the field of multicriteria decision analysis (MCDA). Published by Elsevier Inc. C1 [Linkov, Igor] US Army, Engineer Res & Dev Ctr, Brookline, MA 02446 USA. [Satterstrom, F. Kyle] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA USA. [Corey, Lisa M.] Intertox Inc, Seattle, WA USA. RP Linkov, I (reprint author), US Army, Engineer Res & Dev Ctr, 83 Winchester St,Suite 1, Brookline, MA 02446 USA. EM igor.linkov@usace.army.mil FU US Army Engineer Research and Development Center FX This study was supported in parts by the US Army Engineer Research and Development Center. NR 14 TC 93 Z9 96 U1 2 U2 31 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1549-9634 J9 NANOMED-NANOTECHNOL JI Nanomed.-Nanotechnol. Biol. Med. PD JUN PY 2008 VL 4 IS 2 BP 167 EP 171 DI 10.1016/j.nano.2008.01.001 PG 5 WC Nanoscience & Nanotechnology; Medicine, Research & Experimental SC Science & Technology - Other Topics; Research & Experimental Medicine GA 397NB UT WOS:000262668300010 PM 18329962 ER PT J AU Hill, MJ McWilliams, GD Garcia-Sur, D Chen, B Munroe, M Hoeldtke, NJ AF Hill, Micah J. McWilliams, Grant D. Garcia-Sur, Denise Chen, Bruce Munroe, Michelle Hoeldtke, Nathan J. TI The effect of membrane sweeping on prelabor rupture of membranes - A randomized controlled trial SO OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 56th Annual Clinical Meeting of the American-College-of-Obstetricians-and-Gynecologists CY MAY 03-07, 2008 CL New Orleans, LA SP Amer Coll Obstetricians & Gynecologists ID FORMAL INDUCTION; LABOR; PREGNANCY; REDUCE; CERVIX; WOMEN; TERM; NEED AB OBJECTIVE: To estimate if membrane sweeping increases the rate of prelabor rupture of membranes. METHODS: This randomized trial of term, uncomplicated pregnancies included 300 patients. Patients were randomly assigned into sweep or no-sweep groups, with patients and delivering providers blinded to group allocation. Only the examining provider in the clinic was unblinded to group allocation. Membranes were then swept or not swept at each weekly visit from 38 weeks of gestation onward, depending on the randomization. Data collected included parity, cervix examination at each visit, estimated gestational age at delivery, rupture of membranes, and maternal or fetal complications. RESULTS: A total of 162 patients were randomly assigned to the membrane sweep group and 138 to the no-sweep group. There was no difference in baseline characteristics or obstetric and neonatal outcomes between the groups. The average gestational age at delivery and induction rate were not different. The overall prelabor rupture of membranes rate was not significantly higher in the membrane sweep group (12% compared with 7%) (P=.19); however, patients with a cervix more than 1 cm dilated at time of membrane sweeping were more likely to have prelabor rupture of membranes if they were in the membrane sweep group (9.1% compared with 0%; relative risk 1.10, 95% confidence interval 1.03-1.18). CONCLUSION: No benefit in gestational age at delivery or reduction of postmaturity occurred from membrane sweeping. Although the overall prelabor rupture of membranes rates were similar, patients with membrane sweeping occurring at more than 1 cm cervical dilation may be at increased risk of prelabor rupture of membranes. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www. clinicaltrials.gov, NCT00294242. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. Madigan Army Med Ctr, Tacoma, WA 98431 USA. Mid S Perinatal Associates, Jackson, TN USA. RP Hill, MJ (reprint author), Blanchfield Army Community Hosp, 650 Joel Dr, Ft Campbell, KY 42223 USA. EM micahj.hill@us.army.mil RI Hill, Micah/A-6777-2009 NR 14 TC 4 Z9 5 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JUN PY 2008 VL 111 IS 6 BP 1313 EP 1319 DI 10.1097/AOG.0b013e31816fdcf3 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 305PX UT WOS:000256191400010 PM 18515514 ER PT J AU Stany, MP Hamilton, CA AF Stany, Michael P. Hamilton, Chad A. TI Benign disorders of the ovary SO OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA LA English DT Article ID AUTOIMMUNE HEMOLYTIC-ANEMIA; ADNEXAL MASSES; LAPAROSCOPIC MANAGEMENT; CLINICOPATHOLOGICAL ANALYSIS; TUBOOVARIAN-ABSCESS; BRENNER TUMORS; DERMOID CYSTS; CELL TUMORS; PREGNANCY; WOMEN AB Most ovarian disorders are benign, with the majority being functional ovarian cysts and benign neoplasms. Imaging can often aid in diagnosis and risk assessment. Benign ovarian disorders are frequently incidental findings, but they may cause symptoms from hormonal overproduction, mass effects, or torsion. In addition to symptoms, any ovarian abnormality can raise the specter of malignancy Knowledge of the cause, presentation, and natural history of these benign ovarian disorders helps providers counsel and treat patients appropriately. C1 [Stany, Michael P.; Hamilton, Chad A.] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. RP Hamilton, CA (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM chad.hamilton@amedd.army.mil NR 77 TC 14 Z9 14 U1 0 U2 4 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0889-8545 J9 OBSTET GYN CLIN N AM JI Obstet. Gynecol. Clin. N. Am. PD JUN PY 2008 VL 35 IS 2 BP 271 EP + DI 10.1016/j.ogc.2008.03.004 PG 15 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 316LP UT WOS:000256951500009 PM 18486841 ER PT J AU Warner, D Brietzke, SE AF Warner, Danielle Brietzke, Scott E. TI Mitomycin C and airway surgery: How well does it work? SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 111th Annual Meeting of the American-Academy-of-Otolaryngology-Head-and-Neck-Surgery-Foundation CY SEP 16-19, 2007 CL Washington, DC SP Amer Acad Otolaryngol Head & Neck Surg Fdn ID LARYNGOTRACHEAL RECONSTRUCTION; SUBGLOTTIC STENOSIS; TRACHEAL STENOSIS; PREVENTION; MODEL; LARYNGEAL; BENEFITS AB OBJECTIVE: Systematically review and critically evaluate all available published data on the use of topical mitomycin C (MMC) as an adjunctive in airway surgery. DATA SOURCES: Published studies indexed in MEDLINE, EMBASE, or Cochrane databases. Inclusion criteria were English language, sample size greater than five, and publication of data applicable to the analysis of topical MMC and airway surgery outcomes. REVIEW METHODS: Evidence tables were compiled to include sample size, study design, and evidence level. Summary statistics, random-effects modeling, and subgroup analysis were performed. RESULTS: Twenty manuscripts (eight human, 12 animal) met the inclusion criteria. Seven of eight (87.5%) of the human studies and eight of 12 (66%) animal studies concluded topical MMC was beneficial to airway surgical outcomes. Eleven of twelve animal studies included randomization and a control group, compared with only two of eight human studies. Random-effects modeling of human studies (k=7) indicated that 81.4 percent (95% CI, 72.0%-90.9%; P < 0.001) of patients had improved outcomes attributable to MMC. Random-effects modeling of animal data included modeling of change in airway diameter (Hedge's G = -0.03; 95% Cl, -0.66-0.60; P = 0.924) and the change in histologic measures (Hedge's G = 1.26; 95% CI, 0.596-1.92; P < 0.001) in MMC-treated animals vs controls. CONCLUSION: The majority of the published literature individually suggests the use of topical MMC improves airway surgery outcomes. However, heterogeneity within the clinical studies, the lack of controlled data, and the lack of significance in the pooled animal data (other than histologic outcomes) suggest that the utility of MMC is still undetermined. (C) 2008 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 [Warner, Danielle; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Scott.brietzke@na.amedd.army.mil OI Brietzke, Scott/0000-0002-2844-6026 NR 23 TC 17 Z9 20 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUN PY 2008 VL 138 IS 6 BP 700 EP 709 DI 10.1016/j.otohns.2008.02.011 PG 10 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 306XO UT WOS:000256281900002 PM 18503839 ER PT J AU Mibei, EK Otieno, WO Orago, ASS Stoute, JA AF Mibei, E. K. Otieno, W. O. Orago, A. S. S. Stoute, J. A. TI Distinct pattern of class and subclass antibodies in immune complexes of children with cerebral malaria and severe malarial anaemia SO PARASITE IMMUNOLOGY LA English DT Article DE cerebral malaria; circulating immune complexes; malaria; anaemia ID PLASMODIUM-FALCIPARUM MALARIA; TUMOR-NECROSIS-FACTOR; COMPLEMENT-REGULATORY PROTEINS; IGG SUBCLASSES; BLOOD MONOCYTES; RED-CELLS; RESPONSES; ASSOCIATION; PROTECTION; AUTOANTIBODIES AB Plasmodium falciparum infection can lead to deadly complications such as severe malaria-associated anaemia (SMA) and cerebral malaria (CM). Children with severe malaria have elevated levels of circulating immune complexes (ICs). To further investigate the quantitative differences in antibody class/subclass components of ICs in SMA and CM, we enrolled 75 children with SMA and 32 children with CM from hospitals in western Kenya and matched them to 74 and 52 control children, respectively, with uncomplicated symptomatic malaria. Total IgG IC levels were always elevated in children with malaria upon enrolment, but children with CM had the highest levels of any group. Conditional logistic regression showed a borderline association between IgG4-containing IC levels and increased risk of SMA (OR = 3.11, 95% CI 1.01-9.56, P = 0.05). Total IgG ICs (OR = 2.84, 95% CI 1.08-7.46, P = 0.03) and IgE-containing ICs (OR = 6.82, OR 1.88-24.73, P <= 0.01) were associated with increased risk of CM. These results point to differences in the contribution of the different antibody class and subclass components of ICs to the pathogenesis of SMA and CM and give insight into potential mechanisms of disease. C1 [Stoute, J. A.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Mibei, E. K.; Orago, A. S. S.] Kenyatta Univ, Dept Preclin Sci, Nairobi, Kenya. [Otieno, W. O.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Stoute, J. A.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Stoute, JA (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jose.stoute@us.army.mil FU FIC NIH HHS [1 D43 TW06239]; NHLBI NIH HHS [R01 HL 7502] NR 41 TC 15 Z9 15 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD JUN PY 2008 VL 30 IS 6-7 BP 334 EP 341 DI 10.1111/j.1365-3024.2008.01030.x PG 8 WC Immunology; Parasitology SC Immunology; Parasitology GA 308TN UT WOS:000256413000003 PM 18466201 ER PT J AU Sen, S Hong, J Bang, J Avalos, E Doney, R AF Sen, Surajit Hong, Jongbae Bang, Jonghun Avalos, Edgar Doney, Robert TI Solitary waves in the granular chain SO PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS LA English DT Review ID IMPULSE PROPAGATION; HERTZIAN CHAINS; BEADS; IMPURITIES; EXISTENCE; DYNAMICS; CONTACT; GRAVITY; MODEL; ASSEMBLIES AB Solitary waves are lumps of energy. We consider the study of dynamical solitary waves, meaning cases where the energy lumps are moving, as opposed to topological solitary waves where the lumps may be static. Solitary waves have been studied in some form or the other for nearly 450 years. Subsequently, there have been many authoritative works on solitary waves. Nevertheless, some of the most recent studies reveal that these peculiar objects are far more complex than what we might have given them credit for. In this review, we introduce the physics of solitary waves in alignments of elastic beads, such as glass beads or stainless steel beads. We show that any impulse propagates as a new kind of highly interactive solitary wave through such an alignment and that the existence of these waves seems to present a need to re-examine the very definition of the concept of equilibrium. We further discuss the possibility of exploiting nonlinear properties of granular alignments to develop exciting technological applications. (C) 2008 Elsevier B.V. All rights reserved. C1 [Hong, Jongbae; Bang, Jonghun] Seoul Natl Univ, Dept Phys, Seoul 151747, South Korea. [Sen, Surajit; Avalos, Edgar] SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA. [Avalos, Edgar] Natl Cent Univ, Grad Inst Biophys, Chungli 320, Taiwan. [Avalos, Edgar] Natl Cent Univ, Ctr Complex Syst, Chungli 320, Taiwan. [Doney, Robert] USA, Aberdeen Proving Ground, MD 21005 USA. RP Hong, J (reprint author), Seoul Natl Univ, Dept Phys, Seoul 151747, South Korea. EM jbhong@snu.ac.kr NR 127 TC 200 Z9 202 U1 1 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0370-1573 J9 PHYS REP JI Phys. Rep.-Rev. Sec. Phys. Lett. PD JUN PY 2008 VL 462 IS 2 BP 21 EP 66 DI 10.1016/j.physrep.2007.10.007 PG 46 WC Physics, Multidisciplinary SC Physics GA 325ZS UT WOS:000257628300001 ER PT J AU Liu, X Engel, CC Armstrong, DW Kang, H AF Liu, Xian Engel, Charles C. Armstrong, David W. Kang, Han TI Survival convergence and the preceding mortality crossover for two population subgroups SO POPULATION RESEARCH AND POLICY REVIEW LA English DT Article DE differential mortality; aged persons; survival analysis; population subgroups ID LONGITUDINAL GOMPERTZIAN ANALYSIS; LARGE MEDFLY COHORTS; MAXIMUM LIFE-SPAN; OLDER AGES; HETEROGENEITY; PATHWAYS; DYNAMICS; MODELS; RATES AB In this paper, we present and develop the argument that if the survival functions for two population subgroups converge in later life, a mortality crossover must precede the occurrence of this convergence. Specifically, two survival curves, S-1(x) and S-2(x), associated with two distinct population subgroups, G(1) and G(2), tend to converge before all members die out, as often observed and anticipated. This convergence leads to an increased mortality acceleration for the "advantaged" group, and eventually fosters the occurrence of a mortality crossover. We present a mathematical proof for this relationship and offer several explanations for the mechanisms involved in the process of survival convergence and the preceding mortality crossover. This new presentation demonstrates that mortality crossover is a highly observable demographic event given the trend of survival convergence in later life. C1 [Liu, Xian; Engel, Charles C.; Armstrong, David W.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. [Liu, Xian; Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Kang, Han] Environm Epidemiol Serv, Dept Vet Affairs, Washington, DC 20420 USA. RP Liu, X (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, 6900 Georgia Ave,NW,Bldg 2,3Eo1, Washington, DC 20307 USA. EM xian.liu@na.amedd.army.mil NR 36 TC 2 Z9 2 U1 0 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0167-5923 J9 POPUL RES POLICY REV JI Popul. Res. Policy Rev. PD JUN PY 2008 VL 27 IS 3 BP 293 EP 306 DI 10.1007/s11113-007-9063-4 PG 14 WC Demography SC Demography GA 292HK UT WOS:000255256900002 ER PT J AU Furusato, B Shaheduzzaman, S Petrovics, G Dobi, A Seifert, M Ravindranath, L Nau, ME Werner, T Vahey, M McLeod, DG Srivastava, S Sesterhenn, IA AF Furusato, B. Shaheduzzaman, S. Petrovics, G. Dobi, A. Seifert, M. Ravindranath, L. Nau, M. E. Werner, T. Vahey, M. McLeod, D. G. Srivastava, S. Sesterhenn, I. A. TI Transcriptome analyses of benign and malignant prostate epithelial cells in formalin-fixed paraffin-embedded whole-mounted radical prostatectomy specimens SO PROSTATE CANCER AND PROSTATIC DISEASES LA English DT Article DE formalin-fixed paraffin-embedded tissue; array; gene chip; prostatectomy ID GENE-EXPRESSION; CANCER; TISSUE; RACEMASE; RECEPTOR; MARKER AB Formalin-fixed paraffin-embedded (FFPE) prostate specimens are rich sources of molecular pathological information. However, FFPE-based microarray analysis of tissue samples may be hampered by the degradation and chemical alteration of RNA molecules due to the preservation procedure. In this report, we employed a probe analyses of Affymetrix oligonucleotide arrays at individual probe level to compensate for the potential loss of gene identifications associated with compromised mRNA quality in FFPE preparations. Furthermore, to increase the sample quality, we utilized laser capture microdissection of prostate tumor and benign epithelial cells. Remarkably, combination of these approaches recapitulated the common prostate cancer-associated gene expression alteration. Identification of prostate cancer associated-gene expression alterations such as AMACR, Kallikrein gene family and genes associated with androgen signaling such as PDEF and STEAP were consistent with previous findings reported in prostate cancer. These data suggest that combination of laser capture dissection with computational enhancement of microarray data may be useful for the assessment of gene expression changes in FFPE prostate cancer specimens. C1 [Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Furusato, B.; Shaheduzzaman, S.; Petrovics, G.; Dobi, A.; Ravindranath, L.; Srivastava, S.] Univ Hlth Sci, Dept Surg Uniformed Serv, Ctr Prostate Dis Res, Rockville, MD USA. [Seifert, M.; Werner, T.] Genomatix Software GmbH, Munich, Germany. [Nau, M. E.; Vahey, M.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. [McLeod, D. G.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. RP Sesterhenn, IA (reprint author), Armed Forces Inst Pathol, Dept Genitourinary Pathol, 6825 16th St NW,Bldg 54,PB13, Washington, DC 20306 USA. EM sesterhe@afip.osd.mil OI Furusato, Bungo/0000-0003-4614-9882 NR 17 TC 15 Z9 15 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1365-7852 J9 PROSTATE CANCER P D JI Prostate Cancer Prostatic Dis. PD JUN PY 2008 VL 11 IS 2 BP 194 EP 197 DI 10.1038/sj.pcan.4501007 PG 4 WC Oncology; Urology & Nephrology SC Oncology; Urology & Nephrology GA 300WS UT WOS:000255856700015 PM 17768422 ER PT J AU Reeves, TE Wales, ME Grimsley, JK Li, P Cerasoli, DM Wild, JR AF Reeves, T. E. Wales, M. E. Grimsley, J. K. Li, P. Cerasoli, D. M. Wild, J. R. TI Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities SO PROTEIN ENGINEERING DESIGN & SELECTION LA English DT Article DE cation-pi interactions; chemical warfare agents; organophosphorus hydrolase; protein stability; rational design ID ACTIVE-SITE RESIDUES; ORGANOPHOSPHORUS HYDROLASE; 3-DIMENSIONAL STRUCTURE; BACTERIAL PHOSPHOTRIESTERASE; PSEUDOMONAS-DIMINUTA; ENZYMATIC-HYDROLYSIS; DIRECTED EVOLUTION; NERVE AGENTS; SUBSTRATE; CLONING AB Rational site-directed mutagenesis and biophysical analyses have been used to explore the thermodynamic stability and catalytic capabilities of organophosphorus hydrolase (OPH) and its genetically modified variants. There are clear trade-offs in the stability of modifications that enhance catalytic activities. For example, the H254R/H257L variant has higher turnover numbers for the chemical warfare agents VX (144 versus 14 s(-1) for the native enzyme (wild type) and VR (Russian VX, 465 versus 12 s(-1) for wild type). These increases are accompanied by a loss in stability in which the total Gibb's free energy for unfolding (Delta G(H2O)) is 19.6 kcal/mol, which is 5.7 kcal/mol less than that of the wild-type enzyme. X-ray crystallographic studies support biophysical data that suggest amino acid residues near the active site contribute to the chemical and thermal stability through hydrophobic and cation-pi interactions. The cation-pi interactions appear to contribute an additional 7 kcal/mol to the overall global stability of the enzyme. Using rational design, it has been possible to make amino acid changes in this region that restored the stability, yet maintained effective V-agent activities, with turnover numbers of 68 and 36 s(-1) for VX and VR, respectively. This study describes the first rationally designed, stability/activity balance for an OPH enzyme with a legitimate V-agent activity, and its crystal structure. C1 [Reeves, T. E.; Wales, M. E.; Grimsley, J. K.; Li, P.; Wild, J. R.] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA. [Reeves, T. E.; Cerasoli, D. M.] USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Wild, JR (reprint author), Texas A&M Univ, Dept Biochem & Biophys, TAMU 2128, College Stn, TX 77843 USA. EM j-wild@tamu.edu FU NINDS NIH HHS [U01 NS058035-07] NR 39 TC 24 Z9 25 U1 0 U2 10 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1741-0126 J9 PROTEIN ENG DES SEL JI Protein Eng. Des. Sel. PD JUN PY 2008 VL 21 IS 6 BP 405 EP 412 DI 10.1093/protein/gzn019 PG 8 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 306YV UT WOS:000256285400006 PM 18434422 ER PT J AU Wagner, TD Yang, GY AF Wagner, Timothy D. Yang, Gary Y. TI Cetuximab: Its use in combination with radiation therapy and chemotherapy in the multimodality treatment of head and neck cancer SO RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY LA English DT Review DE cetuximab; squamous cell carcinoma of the head and neck; radiation therapy; concurrent chemotherapy and radiation; epidermal growth factor receptor; targeted therapy ID GROWTH-FACTOR RECEPTOR; SQUAMOUS-CELL CARCINOMA; METASTATIC COLORECTAL-CANCER; PLATINUM-BASED CHEMOTHERAPY; COOPERATIVE-ONCOLOGY-GROUP; MONOCLONAL-ANTIBODIES; EGFR INHIBITORS; PHASE-II; SIGNAL-TRANSDUCTION; LARYNGEAL-CANCER AB Dimerization of epidermal growth factor receptor (EGFR) on the cell membrane of tumor cells has been implicated in triggering a complex signal cascade that leads to increased tumor proliferation and survival. Cetuximab is a human-murine chimeric monoclonal antibody designed to target EGFR and competitively inhibit dimerization by circulating ligands. By this mechanism, it works to prevent this signal cascade thus hindering tumor proliferation. Cetuximab has been shown in a randomized phase III clinical trial to significantly increase overall survival when it is added to radiation therapy in the treatment of locally advanced squamous cell carcinoma of the head and neck. In this manuscript, the mechanism of cetuximab with its associated patents is reviewed, with its role with chemotherapy and radiation in the management of head and neck cancer along with future directions of this targeted cancer therapy. C1 [Wagner, Timothy D.] Brooke Army Med Ctr, Radiat Oncol Serv, Dept Radiol, Med Crops United States Army Staff Radiat Oncol, Ft Sam Houston, TX 78234 USA. [Yang, Gary Y.] Roswell Pk Canc Ctr, Dept Radiat Med, Buffalo, NY USA. RP Wagner, TD (reprint author), Brooke Army Med Ctr, Radiat Oncol Serv, Dept Radiol, Med Crops United States Army Staff Radiat Oncol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM timothy.wagner@amedd.army.mil NR 84 TC 3 Z9 3 U1 0 U2 0 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1574-8928 EI 2212-3970 J9 RECENT PAT ANTI-CANC JI Recent Patents Anti-Canc. Drug Discov. PD JUN PY 2008 VL 3 IS 2 BP 76 EP 83 DI 10.2174/157489208784638776 PG 8 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA 311SD UT WOS:000256619000002 PM 18537749 ER PT J AU McMullin, NR Hedner, U Ezban, M Lauritzen, B Prince, MD Holcomb, JB Sondeen, JL AF McMullin, Neil R. Hedner, Ulla Ezban, Mirella Lauritzen, Brian Prince, M. Dale Holcomb, John B. Sondeen, Jill L. TI Recombinant factor VIIa reduces rebleed hemorrhage volume in a swine aortotomy model: A randomized double-blinded study SO SHOCK LA English DT Article DE low dose; hypotensive; resuscitation; prophylaxis; splenectomized ID V LIVER-INJURIES; ACTIVATED FACTOR-VII; COAGULOPATHIC PIGS; TRAUMATIC COAGULOPATHY; BLOOD-LOSS AB Noncompressible hemorrhage requires hypotensive resuscitation until definitive measures can be taken to prevent rebleeding by sustaining blood pressure at subphysiological levels. Previous studies have demonstrated that a 180- or 720-mu g kg(-1) dose of recombinant factor VIIa (rFVIIa) increases the MAP at which rebleeding occurs in a swine aorlotomy model. The purpose of the current study was to determine the efficacy of a lower dose of 90 mu g kg(-1) given prophylactically to prevent or reduce rebleeding in a prospective, randomized, blinded study using a porcine model of uncontrolled hemorrhage and resuscitation. Fourteen female 40-kg Yorkshire-cross pigs were splenectomized and instrumented with venous and arterial catheters. The infrarenal aorta was exposed, and suction catheters were placed along the right and left paracolic gutters. After a 10-min baseline, 90 mu g kg(-1) (i.v.) of either rFVIIa (n = 6) or vehicle (n = 8) was administered. Five minutes later, an aortotomy was created using a 2.5-mm biopsy punch. The weight of the shed blood was continuously recorded. Lactated Ringer's was given (100 mL kg(-1) min(-1)) 10 min after aortotomy until rebleeding occurred. The MAP at rebleed and the subsequent rebleed hemorrhage volume was recorded over the 2-h study period. After rebleed occurred, lactated Ringer's sufficient to maintain MAP at baseline levels was given. Initial hemorrhage volume and rebleed MAP (P = 0.31) did not differ significantly between groups. Rebleed hemorrhage volume was reduced by 54% in the rFVIIa group from 79 +/- 4 mL kg(-1) in the vehicle group to 43 +/- 6 mL kg(-1) in the rFVIIa group (mean +/- SEM; P < 0.005). The MAP at which rebleed occurred was not different between the groups, 71 +/- 4 mmHg in the rFVIIa group versus 59 5 in the vehicle group. Prophylactic administration of rFVIIa at 90 mu g kg(-1), a dose similar to the recommended dose in hemophilia patients with inhibitors, reduced rebleed hemorrhage volume, suggesting that this dose is effective in this swine aortotomy model. C1 [McMullin, Neil R.; Prince, M. Dale; Holcomb, John B.; Sondeen, Jill L.] USA, Inst Surg Res, San Antonio, TX USA. [Hedner, Ulla; Ezban, Mirella; Lauritzen, Brian] Novo Nordisk AS, Malov, Denmark. RP Sondeen, JL (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM jill.sondeen@us.army.mil NR 18 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2008 VL 29 IS 6 BP 703 EP 708 DI 10.1097/SHK.0b013e31815dbcbf PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SC UT WOS:000256409300010 PM 18496136 ER PT J AU Klemcke, HG Baer, DG Pankratz, VS Cox, A Cortez, DS Garrett, MR Joe, B Ryan, KL AF Klemcke, Harold G. Baer, David G. Pankratz, V. Shane Cox, Ashley Cortez, Douglas S. Garrett, Michael R. Joe, Bina Ryan, Kathy L. TI Is survival time after hemorrhage a heritable, quantitative trait?: An initial assessment SO SHOCK LA English DT Article DE inbred rats; genetic determinants; hemorrhagic shock; differential survival ID ISCHEMIA-REPERFUSION INJURY; COMBAT CASUALTY CARE; RAT SMALL-INTESTINE; BLOOD-VOLUME; GENETIC-VARIATION; TRAUMATIC INJURY; INBRED STRAINS; MUCOSAL INJURY; GENOMICS; DEATH AB Enhancing survival to hemorrhage of both civilian and military patients is a major emphasis for trauma research. Previous observations in humans and outbred rats show differential survival to similar levels of hemorrhage. In an initial attempt to determine potential genetic components of such differential outcomes, survival time after a controlled hemorrhage was measured in 15 inbred strains of rats. Anesthetized rats were catheterized, and approximately 24 h later, 55% of the calculated blood volume was removed during a 26-min period from conscious unrestrained animals. Rats were observed for a maximum of 6 h. Survival time was 7.7-fold longer in the longest-lived strain (Brown Norway/Medical College of Wisconsin; 306 36 min; mean +/- SEM) than in the shortest-lived strain (DA; 40 +/- 5 min; P <= 0.01). Mean survival times for the remaining inbred strains ranged from 273 +/- 44 to 49 +/- 4 min (Dahl-Salt Sensitive > Brown Norway > Munich Wistar Fromter > Dahl-Salt Resistant > Copenhagen > Noble > Spontaneous-hypertensive > Lewis > BDIX > Fawn Hooded Hypertensive > FISCHER 344 > Black agouti > PVG). The variance in the hazard of death attributable to different strains was estimated to be 1.22 log-hazard units, corresponding to a heritability of approximately 48%. Graded and divergent survival times to hemorrhage in inbred rat strains are remarkable and suggest multiple genetic components for this characteristic. However, this interpretation of differential responses to hemorrhage may be confounded by potential strain-associated differences related to the surgical preparation. Identification of inbred strains divergent in survival time to hemorrhage provides the opportunity for future use of these strains to identify genes associated with this complex response. C1 [Klemcke, Harold G.; Baer, David G.; Cox, Ashley; Cortez, Douglas S.; Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Pankratz, V. Shane] Mayo Clin, Coll Med, Rochester, MN USA. [Garrett, Michael R.; Joe, Bina] Univ Toledo Hlth Sci, Dept Physiol Pharmacol Metabol & Cardiovasc Sci, Toledo, OH USA. RP Klemcke, HG (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM harold.klemcke@amedd.army.mil NR 65 TC 9 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2008 VL 29 IS 6 BP 748 EP 753 DI 10.1097/SHK.0b013e31815cfe30 PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 308SC UT WOS:000256409300016 PM 17998886 ER PT J AU Ulrich, MP AF Ulrich, Marybeth Peterson TI The Kremlin and the high command: Presidential impact on the Russian military from Gorbachev to Putin SO SLAVIC REVIEW LA English DT Book Review C1 [Ulrich, Marybeth Peterson] USA, War Coll, Washington, DC 20310 USA. RP Ulrich, MP (reprint author), USA, War Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SLAVIC STUDIES PI CAMBRIDGE PA HARVARD UNIV, 8 STORY ST, 3RD FL, CAMBRIDGE, MA 02138 USA SN 0037-6779 J9 SLAVIC REV JI Slavic Rev. PD SUM PY 2008 VL 67 IS 2 BP 527 EP 528 PG 2 WC Area Studies; Humanities, Multidisciplinary SC Area Studies; Arts & Humanities - Other Topics GA 304ND UT WOS:000256115300081 ER PT J AU Li, B Shang, L Marcus, MS Clare, TL Perkins, E Hamers, RJ AF Li, Bo Shang, Lu Marcus, Matthew S. Clare, Tarni Lasseter Perkins, Edward Hamers, Robert J. TI Chemoselective nanowire fuses: Chemically induced cleavage and electrical, detection of carbon nanofiber bridges SO SMALL LA English DT Article DE biosensors; disulfides; molecular recognition; nanoelectronics; switches ID FIELD-EFFECT-TRANSISTOR; ELECTROCHEMICAL BIOSENSORS; BIOMOLECULAR RECOGNITION; SENSORS; NANOSENSORS; DNA; HYDROGEN; GROWTH; ARRAYS AB A new type of nanoscale bioswitch based on the electrical detection of chemically induced cleavage of chemical bonds, which bind individual nanowires across a pair of electrodes is demonstrated. Carbon nanofibers are manipulated using dielectrophoresis to form single-nanowire bridges across microelectrode junctions, and are anchored through a biomolecular interaction. Once in place, chemically induced cleavage of a recognition site along the bonds linking the nanowire to the electrodes allows the nanowire to be easily removed by a flow of fluid; this removal can be detected in real time via changes in the AC electrical response. This form of sensing is inherently digital in nature as the removal of a single nanowire produces a sudden decrease in the current between electrodes and is essentially a chemoselective fuse. These results suggest that this sensing principle could be a general method for digital chemical and/or biological sensing using individual nanowires. C1 [Li, Bo; Shang, Lu; Marcus, Matthew S.; Clare, Tarni Lasseter; Hamers, Robert J.] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA. [Perkins, Edward] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Hamers, RJ (reprint author), Univ Wisconsin, Dept Chem, 1101 Univ Ave, Madison, WI 53706 USA. EM rjhamers@wisc.edu RI Hamers, Robert/C-6466-2008; OI Hamers, Robert/0000-0003-3821-9625; Clare, Tami/0000-0003-2154-6275 NR 39 TC 6 Z9 6 U1 3 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1613-6810 J9 SMALL JI Small PD JUN PY 2008 VL 4 IS 6 BP 795 EP 801 DI 10.1002/smll.200700944 PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 324WC UT WOS:000257549100018 PM 18535991 ER EF