FN Thomson Reuters Web of Science™ VR 1.0 PT S AU Osgood, RM Steeves, DM Belton, LE Welch, JR Nagarajan, R Quigley, C Walsh, GF Tabiryan, NV Serak, S Kimball, BR AF Osgood, R. M., III Steeves, D. M. Belton, L. E. Welch, J. R. Nagarajan, R. Quigley, Caitlin Walsh, G. F. Tabiryan, N. V. Serak, S. Kimball, B. R. BE Bandaru, PR Grego, S Kinloch, I TI Optical properties of nanoparticle-doped azobenzene liquid crystals SO NANOTUBES, NANOWIRES, NANOBELTS AND NANOCOILS - PROMISE, EXPECTATIONS AND STATUS SE Materials Research Society Symposium Proceedings LA English DT Proceedings Paper CT Symposium on Nanotubes, Nanowires, Nanobelts and Nanocoils held at the 2008 MRS Fall Meeting CY DEC 01-04, 2008 CL Boston, MA SP Mat Res Soc AB Liquid crystals (LCs) are anisotropic fluids exhibiting orientational order that can be controlled with external fields. The optical nonlinearity of LCs can be enhanced by doping with azobenzene dyes or nanoparticles such as carbon nanotubes (CNTs). Previous studies have demonstrated modifications of the LC's nematic-isotropic phase transition temperature by the addition of CNTs. In the present paper, we disperse single-wall and multi-wall CNTs in LC cells at the level of 0.1% by weight. We find that the addition of CNTs enhances the response speed of the azobenzene LC. We have developed a theory that allows quantitative characterization of the nonlinear transmission process of a system of crossed polarizers comprising the LC cell. C1 [Osgood, R. M., III; Steeves, D. M.; Belton, L. E.; Welch, J. R.; Nagarajan, R.; Quigley, Caitlin; Walsh, G. F.; Kimball, B. R.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Osgood, RM (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. NR 15 TC 0 Z9 0 U1 2 U2 3 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DRIVE, WARRENDALE, PA 15088-7563 USA SN 0272-9172 BN 978-1-60511-114-8 J9 MATER RES SOC SYMP P PY 2009 VL 1142 BP 105 EP 113 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA BLF59 UT WOS:000270071200015 ER PT S AU Dave, JR Williams, AJ Yao, CP Lu, XCM Tortella, FC AF Dave, Jitendra R. Williams, Anthony J. Yao, Changping Lu, X. -C. May Tortella, Frank C. BE Ottens, AK Wang, KKW TI Modeling Cerebral Ischemia in Neuroproteomics SO NEUROPROTEOMICS: METHODS AND PROTOCOLS SE Methods in Molecular Biology LA English DT Article; Book Chapter DE Ischemic brain injury; MCAo; Proteomics; 2D-gel electrophoresis; Mass spectroscopy; Models of cerebral ischemia; Brain injury; Biomarkers ID TRAUMATIC BRAIN-INJURY; INFLAMMATORY GENE-EXPRESSION; NMDA RECEPTOR ANTAGONIST; ARTERY OCCLUSION; RAT MODEL; LEUKOCYTE INFILTRATION; THROMBOEMBOLIC STROKE; THERAPEUTIC WINDOW; INHIBITOR MLN519; BLOOD-FLOW AB Protein changes induced by traumatic or ischemic brain injury can serve as diagnostic markers as well as therapeutic targets for neuroprotection. The focus of this chapter is to provide a representative overview of preclinical brain injury and proteomics analysis protocols for evaluation and discovery of novel biomarkers. Detailed surgical procedures have been provided for inducing MCAo and implantation of chronic indwelling cannulas for drug delivery. Sample collection and tissue processing techniques for collection of blood, CSF, and brain are also described including standard biochemical methodology for the proteomic analysis of these tissues. The dynamics of proteomic analysis is a multistep process comprising sample preparation, separation, quantification, and identification of proteins. Our approach is to separate proteins first by two-dimensional gel electrophoresis according to charge and molecular mass. Proteins are then fragmented and analyzed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). Identification of proteins can be achieved by comparing the mass-to-charge data to protein sequences in respective databases. C1 [Dave, Jitendra R.; Williams, Anthony J.; Yao, Changping; Lu, X. -C. May; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Dave, JR (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. NR 42 TC 2 Z9 2 U1 1 U2 2 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1064-3745 BN 978-1-934115-84-8 J9 METHODS MOL BIOL JI Methods Mol. Biol. PY 2009 VL 566 BP 25 EP 40 DI 10.1007/978-1-59745-562-6_2 D2 10.1007/978-1-59745-562-6 PG 16 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA BLU16 UT WOS:000271018600002 PM 20058162 ER PT J AU Williams, DJ Creasy, WR McGarvey, DJ Fry, RA Bevilacqua, VLH Durst, HD AF Williams, Daniel J. Creasy, William R. McGarvey, David J. Fry, Roderick A. Bevilacqua, Vicky L. H. Durst, H. Dupont TI Aluminium sulfate and sodium aluminate buffer solutions for the destruction of phosphorus based chemical warfare agents SO NEW JOURNAL OF CHEMISTRY LA English DT Article ID DESTROYING VX; DETOXIFICATION AB Nerve agents VX and GB (sarin) are sequestered and removed by aluminium sulfate and sodium aluminate mixtures adjusted to pH 4 in solution. The products of hydrolysis are removed with the alum floc below NMR detection limits over time depending and the amount of aluminium molar excess relative to agent. Half-lives for GB decomposition are 3.1 h and 1.1 h, respectively, for a 120 and a 1200 molar excess. For VX, the half-lives are 8.5 d and 2.9 d for a 240 and a 5000 molar aluminium excess. In the case of GB,fluorine is sequestered as the hexafluoroaluminate ion. In the case of VX, no phosphorus containing hydrolysis products including the very toxic S-[2-(diisopropyl-amino)-ethyl] methylphosphonothiolate (EA-2192) are detected in the hydrolysate. C1 [Williams, Daniel J.] Kennesaw State Univ, Dept Chem & Biochem, Kennesaw, GA 30144 USA. [Williams, Daniel J.; Creasy, William R.; Fry, Roderick A.] SAIC, Aberdeen Proving Ground, MD 21010 USA. [McGarvey, David J.; Bevilacqua, Vicky L. H.; Durst, H. Dupont] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Williams, DJ (reprint author), Kennesaw State Univ, Dept Chem & Biochem, Kennesaw, GA 30144 USA. EM dwilliam@kennesaw.edu NR 14 TC 2 Z9 2 U1 1 U2 5 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1144-0546 J9 NEW J CHEM JI New J. Chem. PY 2009 VL 33 IS 5 BP 1006 EP 1009 DI 10.1039/b819885c PG 4 WC Chemistry, Multidisciplinary SC Chemistry GA 442SH UT WOS:000265860400010 ER PT J AU Casali, JG Ahroon, WA Lancaster, JA AF Casali, John G. Ahroon, William A. Lancaster, Jeff A. TI A field investigation of hearing protection and hearing enhancement in one device: For soldiers whose ears and lives depend upon it SO NOISE & HEALTH LA English DT Article DE Headsets; hearing-assistive devices; hearing protection; military operations; noise exposure; signal detection; speech communication; weapons noise AB Operational hearing protection and maintenance of audibility of signals and speech are considered force multipliers in military operations, increasing Soldier survivability and lethality. The in-field research described in this paper was conducted to examine operational performance effects of three different hearing enhancement protection systems (HEPS) that are intended to provide both protection and audibility. The experiment utilized operationally-defined measures in full-scale, simulated combat scenarios with Army ROTC Cadet Soldiers as subjects. The Soldiers operational performance was evaluated in two missions: reconnaissance and raid (attack on enemy camp). Both missions had substantial hearing requirements, including communications, signal detection/recognition, and distance judgments. Operational performance was measured by objective metrics of Squad performance, including the distances required to detect an enemy insurgent camp under each HEPS, and by subjective metrics, such as the Armys dimensions of combat-related mission success as evaluated by Army Officers who served as training leaders/observers. Other subjective ratings were obtained after each training exercise from both the Officers and the Soldiers, including detailed impressions about each HEPS after extended use. Two of the three HEPS were electronic sound transmission devices (comprising an ambient sound pass-through filtering and amplification circuit): a Peltor Comtac II circumaural headset (NRR=21; 16 dB maximum gain); and a Communications Enhancement Protection System (CEPS) (NRR=29; 36 dB maximum gain). One passive, level-dependent HEPS was used, the yellow end of the Combat Arms Earplug, which provides amplitude-sensitive attenuation that sharply increases when the ambient sound is above about 110 dB (e.g., due to a gunshot), but which provides an NRR of 0 and very little attenuation below 1000 Hz in lower ambient noise levels. In the military mission entailing location of and attack on an enemy camp, the CEPS device resulted in the longest (earliest) average auditory detection distance of the camp (400 feet), followed by the Peltor (233 feet) and then the Combat Arms Earplug (150 feet), in comparison to detection by the unprotected, normal ear at about 220 feet. Commanding officers ratings of mission performance and overall success slightly favored the electronic HEPS, but these ratings were dependent upon the particular mission undertaken. Ergonomics and usability issues abounded with the electronic HEPS, and the Soldiers subjective ratings showed variability across all three devices, with device preference depending upon the particular dimension being rated (e.g., comfort vs. hearing ability). Clearly, the results of this in-field experiment demonstrate that more development is needed to achieve the levels of hearing performance and user acceptance from the HEPS that is desirable and needed for combat conditions. In this vein, it is important to note that HEPS designs are continually evolving, and certain upgrades to the three devices evaluated in the late 2006 timeframe of this study have occurred and further evaluations are thus warranted. C1 [Casali, John G.; Lancaster, Jeff A.] Virginia Tech, Auditory Syst Lab, Blacksburg, VA USA. [Ahroon, William A.] USA, Aeromed Res Lab USAARL, Ft Rucker, AL USA. RP Casali, JG (reprint author), Virginia Tech Univ, Grado Dept Ind & Syst Engn, ISE Dept, 519G,Whittemore Hall, Blacksburg, VA 24061 USA. EM jcasali@vt.edu NR 13 TC 21 Z9 22 U1 1 U2 6 PU MEDKNOW PUBLICATIONS PI MUMBAI PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA SN 1463-1741 J9 NOISE HEALTH JI Noise Health PD JAN-MAR PY 2009 VL 11 IS 42 BP 69 EP 90 DI 10.4103/1463-1741.48564 PG 22 WC Audiology & Speech-Language Pathology; Public, Environmental & Occupational Health SC Audiology & Speech-Language Pathology; Public, Environmental & Occupational Health GA V15SC UT WOS:000207820700011 PM 19265256 ER PT J AU Cantu, V Fries, JN Ryan, TA AF Cantu, Valentin Fries, Joe N. Ryan, Tom A. TI An Apparatus for Separating Live Amphipods from Debris SO NORTH AMERICAN JOURNAL OF AQUACULTURE LA English DT Article ID HYALELLA-AZTECA AMPHIPODA; DYNAMICS; FISH; LAKE; POPULATIONS; SALAMANDERS; PREDATION; WETLAND; FLORIDA; WATER AB We designed an inexpensive (US$35), easy-to-build apparatus that separates live freshwater amphipods Hyalella azteca from debris. In 2 d of unattended operation, the separator provided an average of 2,700 amphipods from debris per square meter of raceway bottom (range 1,600-4,000/m(2); n = 3). Amphipod-containing debris collection, apparatus setup, and salt treatment of amphipods to kill hydras and flatworms took about 10 min. C1 [Cantu, Valentin; Fries, Joe N.] US Fish & Wildlife Serv, San Marcos Natl Fish Hatchery & Technol Ctr, San Marcos, TX 78666 USA. [Ryan, Tom A.] US Army Corps Engineers, Engn Res & Dev Ctr, Champaign, IL 61821 USA. RP Cantu, V (reprint author), US Fish & Wildlife Serv, San Marcos Natl Fish Hatchery & Technol Ctr, San Marcos, TX 78666 USA. EM valentin_cantu@fws.gov NR 20 TC 1 Z9 1 U1 0 U2 3 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 1522-2055 J9 N AM J AQUACULT JI N. Am. J. Aqualcult. PD JAN PY 2009 VL 71 IS 1 BP 6 EP 9 DI 10.1577/A07-106.1 PG 4 WC Fisheries SC Fisheries GA 421NH UT WOS:000264365100002 ER PT J AU Ravi, G Alvarado, JL Marsh, C Kessler, DA AF Ravi, Gurunarayana Alvarado, Jorge L. Marsh, Charles Kessler, David A. TI Laminar Flow Forced Convection Heat Transfer Behavior of a Phase Change Material Fluid in Finned Tubes SO NUMERICAL HEAT TRANSFER PART A-APPLICATIONS LA English DT Article ID CHANGE-MATERIAL SLURRIES; CHANGE MATERIAL SUSPENSIONS; TRANSFER ENHANCEMENT; WALL TEMPERATURE; CIRCULAR DUCTS; UNIFORM AB The heat transfer behavior of phase change material fluid (PCM) under laminar flow conditions in circular tubes and internally longitudinal finned tubes was studied. An effective specific heat technique was used to model the phase change process. Heat transfer results for a smooth circular tube with PCM fluid were obtained under hydrodynamically and thermally fully developed conditions. Results for the finned tube were obtained using the H2 and T boundary conditions. It was determined that the Nusselt number was strongly dependent on the Stefan number, fin thermal conductivity value, and height of the fins. C1 [Alvarado, Jorge L.] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. [Ravi, Gurunarayana] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Marsh, Charles] USA, Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61824 USA. [Kessler, David A.] Naval Res Lab, Lab Computat Phys & Fluid Dynam, Washington, DC USA. [Marsh, Charles] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. RP Alvarado, JL (reprint author), Texas A&M Univ, Dept Engn Technol & Ind Distribut, 117 Thompson Hall,3367 TAMU, College Stn, TX 77843 USA. EM alvarado@entc.tamu.edu OI Alvarado, Jorge/0000-0002-4059-6588 FU Army Corps Engineers Engineer and Research Development Center and Construction Engineering Research Laboratory; Naval Research Laboratory FX This work was supported in part by the Army Corps Engineers Engineer and Research Development Center and Construction Engineering Research Laboratory, and the Naval Research Laboratory. The authors would also like to thank Satyanarayana Kondle for his support and knowledge of Fluent. NR 23 TC 14 Z9 14 U1 1 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1040-7782 J9 NUMER HEAT TR A-APPL JI Numer. Heat Tranf. A-Appl. PY 2009 VL 55 IS 8 BP 721 EP 738 AR PII 910344601 DI 10.1080/10407780902864672 PG 18 WC Thermodynamics; Mechanics SC Thermodynamics; Mechanics GA 435UT UT WOS:000265369500001 ER PT S AU Karadogan, E Willson, CS Berger, CR AF Karadogan, E. Willson, C. S. Berger, C. R. GP IEEE TI Numerical Modeling of the Lower Mississippi River-Influence of Forcings on Flow Distribution and Impact of Sea Level Rise on the System SO OCEANS 2009, VOLS 1-3 SE OCEANS-IEEE LA English DT Proceedings Paper CT Oceans 2009 Conference CY OCT 26-29, 2009 CL Biloxi, MS SP Marine Technol Soc, IEEE Ocean Engn Soc AB The Mississippi River, with one of the world's largest watersheds draining 41% of the continental U.S., is the seventh largest river in the world. The lower Mississippi River delta system along the northern Gulf of Mexico coast experiences annual coastal marsh losses between 25 and 35 square miles. The lower River is a highly complex system impacted by multiple forcings. An understanding of the hydrodynamics in this system will be important for understanding the potential outcomes of coastal restoration projects such as large-scale River diversions and for future management decisions. This study describes the development and application of a hydrodynamic model of a reach of the Lower Mississippi River from Carrolton (New Orleans) at RM 103 down to the Gulf of Mexico. The USACE Adaptive Hydraulics Model (ADH), an unstructured finite element model, is used to model the hydrodynamics. An unstructured mesh was developed for the study area, which includes detailed bathymetry and topography from the most recent available survey data. The mesh is fine enough to capture the changes in bathymetry and relies upon automated mesh refinement to capture flow details. Mississippi River stage data collected from thirteen stations between Carrolton and Port Eads for the water years between 1987 and 2008 is used in the model calibration. In addition, discharge data collected in various Lower River passes is used to examine the ability of the hydrodynamic model to properly simulate the flow distribution through different reaches and lower River passes. Steady state solutions for water surface elevations at gage locations match well with observational data and the distribution of river flow among the different sections of river channel and passes are consistent with the limited field data available. The effect of the sea level rise is most significant in the lower 20 miles of the river and it loses its effect with increasing flow rates. C1 [Karadogan, E.; Willson, C. S.] Louisiana State Univ, Dept Civil & Environm Engn, Baton Rouge, LA 70803 USA. [Berger, C. R.] US Army, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Karadogan, E (reprint author), Louisiana State Univ, Dept Civil & Environm Engn, Baton Rouge, LA 70803 USA. FU Louisiana Office of Coastal Protection and Restoration (OCPR); Coastal and Hydraulic s Laboratory at the USACE Engineer Research and Development Center; computational staff of Louisiana State University Center for Computation and Technology; Louisiana Optical Network Initiative (LONI); Coastal Environmental Modeling Laboratory (CEML) FX This study is conducted by the fund supplied by Louisiana Office of Coastal Protection and Restoration (OCPR) and in collaboration with Coastal and Hydraulic s Laboratory at the USACE Engineer Research and Development Center. The computational staff of Louisiana State University Center for Computation and Technology, The Louisiana Optical Network Initiative (LONI) and Coastal Environmental Modeling Laboratory (CEML) provided extensive computational resources and support. NR 18 TC 0 Z9 0 U1 0 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0197-7385 BN 978-1-4244-4960-6 J9 OCEANS-IEEE PY 2009 BP 1531 EP + PG 2 WC Engineering, Ocean; Oceanography; Remote Sensing SC Engineering; Oceanography; Remote Sensing GA BPY34 UT WOS:000280322600224 ER PT S AU Macon, CL AF Macon, C. L. GP IEEE TI USACE National Coastal Mapping Program and the Next Generation of Data Products SO OCEANS 2009, VOLS 1-3 SE OCEANS-IEEE LA English DT Proceedings Paper CT Oceans 2009 Conference CY OCT 26-29, 2009 CL Biloxi, MS SP Marine Technol Soc, IEEE Ocean Engn Soc AB The U.S. Army Corps of Engineers (USACE) has been monitoring coastal change for decades. Each coastal district has the duty to maintain the federal navigation channels to insure safe passage for commercial and private vessels. In addition to these navigation channels, monitoring coastal change and regional sediment management rank high in both importance and financial expenditures. Acoustic boat surveys have been and will continue to be a viable way to accomplish these goals. For the past 15 years these surveys efforts have been assisted by the Joint Airborne Lidar Bathymetry Technical Center of eXpertise (JALBTCX). The JALBTCX has in-house survey capability using the U.S. Naval Oceanographic Office's Compact Hydrographic Airborne Rapid Total Survey (CHARTS) system. The CHARTS system collects bathymetric lidar, topographic lidar, RGB imagery, and hyperspectral imagery. CHARTS is mounted on a Beech King Air 200 which provides a platform capable of surveying the federal navigation projects and the areas between to support regional sediment management. In 2004, USACE Headquarters funded JALBTCX to map the sandy shoreline of the continental U.S. on a recurring basis. This mapping effort falls under the National Coastal Mapping Program (NCMP). In addition to the NCMP, JALBTCX performs emergency response surveys following natural disasters. Since 2004, JALBTCX was surveyed after every category 2 (or greater) hurricane that makes land fall within the U.S. As the survey capabilities increase it becomes more difficult for the local engineers to process the large volumes of data and the demand for analysis ready products became a necessity. JALBTCX took on this challenge and is currently delivering a suite of products to meet the needs. With the addition of new sensors, JALBTCX has also been able to develop new data fusion products to assist in monitoring the engineering, economic, and environmental changes to the coastal zone. C1 USA, Corps Engineers Mobile Dist, Joint Airborne Lidar Bathymetry Tech Ctr eXperits, Kiln, MS 39556 USA. RP Macon, CL (reprint author), USA, Corps Engineers Mobile Dist, Joint Airborne Lidar Bathymetry Tech Ctr eXperits, 7225 Stennis Airport Rd,Suite100, Kiln, MS 39556 USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0197-7385 BN 978-1-4244-4960-6 J9 OCEANS-IEEE PY 2009 BP 1592 EP 1598 PG 7 WC Engineering, Ocean; Oceanography; Remote Sensing SC Engineering; Oceanography; Remote Sensing GA BPY34 UT WOS:000280322600232 ER PT S AU Casper, AF Steimle, ET Hall, ML Dixon, B AF Casper, A. F. Steimle, E. T. Hall, M. L. Dixon, B. GP IEEE TI Combined GIS and ROV technologies improve characterization of water quality in Coastal Rivers of the Gulf of Mexico SO OCEANS 2009, VOLS 1-3 SE OCEANS-IEEE LA English DT Proceedings Paper CT Oceans 2009 Conference CY OCT 26-29, 2009 CL Biloxi, MS SP Marine Technol Soc, IEEE Ocean Engn Soc ID AUTONOMOUS UNDERWATER VEHICLES; ST-LAWRENCE-RIVER; VARIABILITY; GROUNDWATER; DESIGN; TRENDS; TIME AB Rivers, estuaries, reservoirs, and lakes are multi-use systems that supply water for agricultural, industrial, and human consumption while simultaneously assimilating both point- and non-point source discharges. Existing methods of data collection are generally limited to snapshots in space and time while a comprehensive view of spatial variability remains elusive. Accelerating the integration of existing in-situ sensors, geospatial analysis techniques, and reliable autonomous sampling platform technologies provide immediate improvements for sampling and assessment programs. We provide a demonstration of this integration for high spatial resolution sampling and analysis in a non-wadeable river with an inexpensive unmanned sampling platform (USV), standards sensor arrays, and widely used geospatial techniques. These are used to creating 2-D maps of temperature, conductivity, salinity, turbidity, chlorophyll florescence and chromophoric dissolved organic matter (CDOM). 2-D surface water quality maps show significant influences on local water quality from tributary confluences, submarine groundwater plumes, floodplain/riparian interfaces and other patchily distributed limnological features. Moreover, this project demonstrates how sensors, autonomous vehicles, and geospatial technologies work in concert to create a more comprehensive spatial picture compared to the standard systematic sampling grid with data displayed as means and standard deviations. C1 [Steimle, E. T.; Hall, M. L.] AEOS, 1040 17th Ave S, St Petersburg, FL 33704 USA. [Casper, A. F.; Steimle, E. T.; Dixon, B.] ERDC Environm Lab, Aquat Ecol & Invas Species Branch, Vicksburg, MS USA. [Casper, A. F.; Dixon, B.] Univ S Florida, Policy & Geog Program, Environm Sci, St Petersburg, FL USA. [Dixon, B.] Univ S Florida, Geo Spatial Analyt Lab, St Petersburg, FL USA. RP Steimle, ET (reprint author), AEOS, 1040 17th Ave S, St Petersburg, FL 33704 USA. EM esteimle@aeosciences.com FU USEPA-ORD through the U. of South Florida St. Petersburg's Center for Science; Policy in the Coastal Environment FX This research was funded by USEPA-ORD through the U. of South Florida St. Petersburgs Center for Science and Policy in the Coastal Environment. NR 32 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0197-7385 BN 978-1-4244-4960-6 J9 OCEANS-IEEE PY 2009 BP 2555 EP + PG 3 WC Engineering, Ocean; Oceanography; Remote Sensing SC Engineering; Oceanography; Remote Sensing GA BPY34 UT WOS:000280322601103 ER PT B AU Okusaga, O Zhou, WM Carter, G Menyuk, C AF Okusaga, Olukayode Zhou, Weimin Carter, Gary Menyuk, Curtis GP IEEE TI Investigating the Forward and Backward Injections of Injection-Locked Dual Optoelectronic Oscillators SO OFC: 2009 CONFERENCE ON OPTICAL FIBER COMMUNICATION, VOLS 1-5 LA English DT Proceedings Paper CT Conference on Optical Fiber Communication (OFC 2009) CY MAR 22-26, 2009 CL San Diego, CA AB An injection-locked optoelectronic oscillator (OEO) is investigated for the effects of simultaneous forward and reverse injections between the master and slave OEOs to find the optimized condition for low phase noise and spurious levels. C1 [Okusaga, Olukayode; Zhou, Weimin] USA, Res Lab, Adelphi, MD 20783 USA. [Okusaga, Olukayode; Carter, Gary; Menyuk, Curtis] UMBC, Baltimore 21250, MD USA. RP Okusaga, O (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM Okusaga1@umbc.edu NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-2606-5 PY 2009 BP 432 EP + PG 2 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA BNJ83 UT WOS:000274764200144 ER PT J AU DeMartelaere, SL Perman, KI Shore, JW AF DeMartelaere, Sheri L. Perman, Kevin I. Shore, John W. TI Reply re: "Orbital Septal Resection and the Hanging Curtain of Fat" SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Letter C1 [DeMartelaere, Sheri L.] Brooke Army Med Ctr, MCHE SDO, Ft Sam Houston, TX 78234 USA. RP DeMartelaere, SL (reprint author), Brooke Army Med Ctr, MCHE SDO, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM sheri.l.demartelaere@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0740-9303 J9 OPHTHAL PLAST RECONS JI Ophthalmic Plast. Reconstr. Surg. PD JAN-FEB PY 2009 VL 25 IS 1 BP 77 EP 77 PG 1 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 398LR UT WOS:000262734100033 ER PT S AU Rivamonte, A AF Rivamonte, Andre BE Manns, F Soderberg, PG Ho, A TI Bottlenose dolphin iris asymmetries enhance aerial and underwater vision SO OPHTHALMIC TECHNOLOGIES XIX SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Ophthalmic Technologies XIX CY JAN 24-26, 2009 CL San Jose, CA SP SPIE, Pascal Rol Fdn, Topcon Adv BioMed Imaging Lab DE bioacoustic imaging; iris asymmetries; operculum; cetaceans; bifocal lens ID EYE; ACUITY; PUPIL AB When the iris of the Bottlenose dolphin (Tursiops truncatus) contracts it constrains the path of light that can focus onto the two areas of the retina having a finer retinal mosaic. Under high ambient light conditions the operculum of the iris shields the lens and forms in the process two asymmetrically shaped, sized and positioned slit pupils. Tracing rays of light in the reverse direction through the pupils from the retinal regions associated with higher resolution confirm behaviorally observed preferred aerial and underwater viewing directions. In the forward and downward viewing direction, the larger temporal pupil admits light that is focused by the weakly refractive margin of a bifocal lens onto the temporal area centralis compensating for the addition of the optically strong front surface of the cornea in air. A schematic dolphin eye model incorporating a bifocal lens offers an explanation for a dolphin's comparable visual acuities in air and water for both high and low ambient light conditions. Comparison of methods for curve fitting psychometric ogive functions to behavioral visual acuity and spectral sensitivity data are discussed. C1 USA, EALD Engn Div, TMDE Act, Redstone Arsenal, AL 35898 USA. RP Rivamonte, A (reprint author), USA, EALD Engn Div, TMDE Act, Redstone Arsenal, AL 35898 USA. NR 35 TC 0 Z9 0 U1 1 U2 6 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7409-4 J9 PROC SPIE PY 2009 VL 7163 AR 716321 DI 10.1117/12.804433 PG 9 WC Ophthalmology; Optics; Physics, Applied; Radiology, Nuclear Medicine & Medical Imaging SC Ophthalmology; Optics; Physics; Radiology, Nuclear Medicine & Medical Imaging GA BSL16 UT WOS:000284821000045 ER PT J AU Henderson, D Smith, JC AF Henderson, Dale Smith, J. Cole TI An exact reformulation-linearisation technique algorithm for solving a parameter extraction problem arising in compact thermal models SO OPTIMIZATION METHODS & SOFTWARE LA English DT Article DE branch-and-bound; computation; compact thermal models; nonlinear optimisation ID LINEAR-PROGRAMMING PROBLEMS; OPTIMIZATION; PACKAGE; DELPHI; WORLD AB Compact thermal models (CTMs) are used to evaluate thermal characteristics of critical electronic chip packages under several hypothetical design and usage scenarios. In order to ensure that CTMs accurately estimate thermal response, an appropriate set of model parameters must first be selected. The challenge arising in this paper is to glean a set of parameters that best describes the performance of CTM over a set of test conditions. We examine a non-convex optimisation formulation for this parameter estimation problem, and derive the first exact optimisation algorithm for the problem using a continuous version of the reformulation-linearisation technique. We provide experimental results on real data to demonstrate the applicability of our approach. C1 [Smith, J. Cole] Univ Florida, Dept Ind & Syst Engn, Gainesville, FL 32611 USA. [Henderson, Dale] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Smith, JC (reprint author), Univ Florida, Dept Ind & Syst Engn, Gainesville, FL 32611 USA. EM cole@ise.ufl.edu FU Air Force Office of Scientific Research [FA9550-08-1-0189] FX The authors gratefully acknowledge the comments made by two referees, which helped to improve our paper. Dr. Smith gratefully acknowledges the support of the Air Force Office of Scientific Research under Grant #FA9550-08-1-0189. NR 30 TC 1 Z9 1 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1055-6788 J9 OPTIM METHOD SOFTW JI Optim. Method Softw. PY 2009 VL 24 IS 4-5 BP 857 EP 870 AR PII 909790290 DI 10.1080/10556780802616924 PG 14 WC Computer Science, Software Engineering; Operations Research & Management Science; Mathematics, Applied SC Computer Science; Operations Research & Management Science; Mathematics GA 481IM UT WOS:000268801200020 ER PT J AU Wipf, P Mo, TT Geib, SJ Caridha, D Dow, GS Gerena, L Roncal, N Milner, EE AF Wipf, Peter Mo, Tingting Geib, Steven J. Caridha, Diana Dow, Geoffrey S. Gerena, Lucia Roncal, Norma Milner, Erin E. TI Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine SO ORGANIC & BIOMOLECULAR CHEMISTRY LA English DT Article ID HIGH YIELDING SYNTHESIS; ANTIMALARIAL ACTIVITY; MEDICINAL CHEMISTRY; P-GLYCOPROTEIN; FLUORINE; MALARIA; PENTAFLUORIDE; RESISTANCE; AGENTS AB Two novel SF(5) analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF(5)-substituted quinolines. C1 [Wipf, Peter; Mo, Tingting; Geib, Steven J.] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Wipf, Peter; Mo, Tingting] Univ Pittsburgh, Ctr Chem Methodol & Lib Dev, Pittsburgh, PA 15260 USA. [Caridha, Diana; Dow, Geoffrey S.; Gerena, Lucia; Roncal, Norma; Milner, Erin E.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Wipf, P (reprint author), Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. EM pwipf@pitt.edu; geoffrey.dow@us.army.mil FU NIGMS NIH HHS [P50 GM067082-07, P50 GM067082] NR 39 TC 57 Z9 57 U1 2 U2 23 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1477-0520 J9 ORG BIOMOL CHEM JI Org. Biomol. Chem. PY 2009 VL 7 IS 20 BP 4163 EP 4165 DI 10.1039/b911483a PG 3 WC Chemistry, Organic SC Chemistry GA 500QZ UT WOS:000270320300003 PM 19795052 ER PT J AU Banks, HD AF Banks, Harold D. TI Is nucleophilic cleavage chemistry practical for 4-membered heterocycles? SO ORGANIC & BIOMOLECULAR CHEMISTRY LA English DT Article ID SUBSTITUTION REACTIONS; AZETIDINE DERIVATIVES; SOLVATION MODELS; AB-INITIO; OXETANES; ACID; REACTIVITY; REGIOSELECTIVITY; AZIRIDINES; ALCOHOLS AB A computational study at the MP2(Full)/6-311++G(d,p)//MP2(Full)/6-31+G(d) level of the ammonolysis of halogen substituted azetidines, oxetanes and thietanes was performed in the gas phase and in the commonly used solvent, acetonitrile. Using the free energy of activation of a benchmark reaction for evaluation of synthetic viability, several haloazetidines and oxetanes that possessed the required reactivity were identified; however, no substituted thietane investigated herein was determined to be synthetically useful under the mild conditions selected for this study. In the case of the azetidines, the side reaction of displacement of halide ion was determined to be the preferred reaction course in acetonitrile; however, the amino product of the reactions of the 2-haloazetidines cleaved at an acceptable rate under mild conditions. For the oxetane derivatives investigated, 2-fluorooxetane proved to be a direct source of ring cleavage product. Nucleophilic cleavage of halogen-substituted azetidines and oxetanes is predicted to be a viable source of functionalized three-carbon moieties under mild conditions in organic synthesis. C1 USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Banks, HD (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM harold.banks@us.army.mil NR 53 TC 3 Z9 3 U1 2 U2 8 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1477-0520 J9 ORG BIOMOL CHEM JI Org. Biomol. Chem. PY 2009 VL 7 IS 21 BP 4496 EP 4501 DI 10.1039/b908861j PG 6 WC Chemistry, Organic SC Chemistry GA 506SH UT WOS:000270795700023 PM 19830301 ER PT J AU Keefe, MA Castro, JR Keefe, MS AF Keefe, Michael A. Castro, Jerry R. Keefe, Morgan S. TI Identification of the facial nerve main trunk by retrograde dissection of the postauricular branch SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article C1 [Keefe, Michael A.] Sharp Mem Hosp & Rehabil Ctr, Div Head & Neck Surg, Sharp Rees Stealy Med Grp, San Diego, CA 92131 USA. [Keefe, Michael A.] Naval Med Ctr San Diego, San Diego, CA 92131 USA. [Castro, Jerry R.] Walter Reed Army Med Ctr, Natl Capitol Consortium, Dept Head & Neck Surg, Washington, DC 20307 USA. [Keefe, Morgan S.] Acad Our Lady Peace, San Diego, CA USA. RP Keefe, MA (reprint author), Sharp Mem Hosp & Rehabil Ctr, Div Head & Neck Surg, Sharp Rees Stealy Med Grp, 10670 Wexlord St, San Diego, CA 92131 USA. EM Michael.KeefeMD@Sharp.Com NR 3 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JAN PY 2009 VL 140 IS 1 BP 126 EP 127 DI 10.1016/j.otohns.2008.10.014 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 394PD UT WOS:000262458100026 PM 19130976 ER PT J AU Bochicchio, C Fletcher, C Dyer, M Smith, T AF Bochicchio, Christopher Fletcher, Charles Dyer, Matthew Smith, Thomas TI Reef-Top Sediment Bodies: Windward O'ahu, Hawai'i SO PACIFIC SCIENCE LA English DT Article ID KAILUA BAY; SUBMARINE; HISTORY AB Hawaiian fringing reefs display sand bodies on their surfaces that are potentially important components of littoral sediment budgets. This work provides a regional survey of modern reef-top sediment storage and investigated geologic controls on sediment storage potential. Sand bodies are formed when sediment accumulates in topographic depressions that are the result of meteoric water eroding the emerged carbonate reef platform during periods of lower sea level. The relief of some depressions may be modified by Holocene reef accretion. Depression morphology exerts a strong control on volume and internal distribution of sediment. In this study a total of 205 jet probe thickness measurements was collected from 54 major sand bodies on the fringing reef (0-20 in depth) adjacent to 22 km of Southeast O'ahu coastline (Kailua, Lanikai, and Waimanalo). Volumes were determined and synthesized with previous volume estimates of coastal subaerial and deeper submarine sediment bodies (20-200 m depth), giving the total sediment storage within the coastal system. Sand bodies range from 50 to 2,800 in from shore. Measured thickness varied from 0 to greater than 3.0 m with a mean of 0.95 m. For this study sand bodies were classified into three dominate morphologies: channel, field, and karst depression. The volume of sediment stored in channels was 58,253 +/- 618 x 10(3) m(3), fields contained 171 +/- 6 x 10(3) m(3), and karst depressions contained 1,332 +/- 248 x 10(3) m(3). Correlation of sediment body distribution with reef and coastal plain morphology revealed potential geologic controls on sand body formation in this region. Meteoric runoff and reef slope are important controls on spatial distribution of sand bodies. C1 [Bochicchio, Christopher; Fletcher, Charles; Dyer, Matthew] Univ Hawaii Manoa Coastal Geol, Dept Geol & Geophys, Honolulu, HI 96822 USA. [Smith, Thomas] USA, Corps Engineers, Pacific Ocean Div, Ft Shafter, HI 96858 USA. RP Bochicchio, C (reprint author), Univ Hawaii Manoa Coastal Geol, Dept Geol & Geophys, 1680 East West Rd,Post 721A, Honolulu, HI 96822 USA. EM bochicch@hawaii.edu FU U.S. Army Corps. of Engineers; U.S. Geological Survey; Hawai'i Department of Land and Natural Resources FX We thank the U.S. Army Corps. of Engineers, U.S. Geological Survey, and the Hawai'i Department of Land and Natural Resources for providing funding for this project. NR 34 TC 7 Z9 7 U1 3 U2 4 PU UNIV HAWAII PRESS PI HONOLULU PA 2840 KOLOWALU ST, HONOLULU, HI 96822 USA SN 0030-8870 J9 PAC SCI JI Pac. Sci. PD JAN PY 2009 VL 63 IS 1 BP 61 EP 82 DI 10.2984/1534-6188(2009)63[61:RSBWOH]2.0.CO;2 PG 22 WC Marine & Freshwater Biology; Zoology SC Marine & Freshwater Biology; Zoology GA 361YQ UT WOS:000260164500005 ER PT S AU Hoover, JJ Turnage, A Killgore, KJ AF Hoover, Jan Jeffrey Turnage, April Killgore, K. Jack BE Paukert, CP Scholten, GD TI Swimming Performance of Juvenile Paddlefish: Quantifying Risk of Entrainment SO PADDLEFISH MANAGEMENT, PROPAGATION, AND CONSERVATION IN THE 21ST CENTURY: BUILDING FROM 20 YEARS OF RESEARCH AND MANAGEMENT SE American Fisheries Society Symposium LA English DT Proceedings Paper CT Symposium on Paddlefish Conservation and Management CY DEC 05, 2006 CL Omaha, NE SP Amer Fisheries Soc ID POLYODON-SPATHULA; FISH; VENTILATION; STURGEON; TESTS AB Rheotaxis, endurance, and behavior of juvenile paddlefish Polyodon spathula (<115 mm eye-to-fork length) were measured in a laboratory swim tunnel. Paddlefish were positively rheotactic (>80% of individuals tested). They exhibited sustained swimming (>= 200 min) at water velocities up to 40 cm/s, prolonged swimming (0.5-52 min) at 30-50 cm/s, and burst swimming (<0.5 min) at water velocities 60-75 cm/s. Behavior consisted exclusively of free swimming in the water column. Fish recovered from white spot Ichthy-ophthirius multifiliis disease appeared healthy but had reduced endurance at low to moderate water velocities. Data were used to quantify risk of entrainment by dredges at a given water velocity as an index, values of which ranged from 0.00 (unlikely) to 1.00 (inevitable). Entrainment risk was evaluated for escape speeds considered environmentally conservative (based on prolonged swim speed) and operationally conservative (based on burst swim speed), using flow field models of three cutterhead dredges having pipe diameters of 71, 51, and 30 cm. Entrainment was likely within a radius of 1.25 m of the cutterhead, but degree of risk and distance of entraining flow varied substantially with pipe size. Entrainment risk of paddlefish can be reduced by (1) temporal restrictions on dredging, (2) stocking juveniles that have not been treated for disease, and (3) use of small diameter pipes (ideally <30 cm). C1 [Hoover, Jan Jeffrey; Turnage, April; Killgore, K. Jack] USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Hoover, JJ (reprint author), USA, Engineer Res & Dev Ctr, Waterways Expt Stn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jan.j.hoover@usace.army.mil NR 39 TC 8 Z9 8 U1 0 U2 6 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE, STE 110, BETHESDA, MD 20814-2199 USA SN 0892-2284 BN 978-1-934874-12-7 J9 AM FISH S S PY 2009 VL 66 BP 141 EP 155 PG 15 WC Fisheries SC Fisheries GA BPB75 UT WOS:000278471300009 ER PT S AU Hoover, JJ Boysen, KA Murphy, CE George, SG AF Hoover, Jan Jeffrey Boysen, Krista A. Murphy, Catherine E. George, Steven G. BE Paukert, CP Scholten, GD TI Morphological Variation in Juvenile Paddlefish SO PADDLEFISH MANAGEMENT, PROPAGATION, AND CONSERVATION IN THE 21ST CENTURY: BUILDING FROM 20 YEARS OF RESEARCH AND MANAGEMENT SE American Fisheries Society Symposium LA English DT Proceedings Paper CT Symposium on Paddlefish Conservation and Management CY DEC 05, 2006 CL Omaha, NE SP Amer Fisheries Soc ID LOWER MISSISSIPPI RIVER; POLYODON-SPATHULA; CYPRINELLA-VENUSTA; BLACKTAIL SHINER; ACIPENSERIFORMES; VENTILATION; VERTEBRATES; LOCOMOTION; STURGEONS; FINS AB Juvenile paddlefish Polyodon spat hula exhibit conspicuous variation in the shape of their rostra and caudal fins. We quantified morphological variation for a composite collection of young-of-year paddlefish (N = 55; 61.9-403.7 mm total length) using nine measurements of the rostrum, body, and caudal fin. Sheared principal component analysis of morphological data resulted in three distinct groups of fish corresponding to three different localities: hatchery-reared fish from the Mermentau River, Louisiana; hatchery-reared fish from the Tombigbee River, Alabama; and field-collected fish from the Mississippi River, Mississippi. Series were segregated from each other based on size of caudal lobes and width of rostrum. With increased body size of fish, relative length of rostrum increased, and mesal expansion of rostrum increased for all three series. For Tombigbee and Mississippi River series, with increased size of fish, caudal asymmetry decreased. Overall, smaller fish had shorter, narrower rostra and highly asymmetrical caudal lobes; larger fish had longer, broader rostra and more symmetrical caudal lobes. Morphological differences among series were most conspicuous for fish greater than 85 mm eye-to-fork length. Fish from Mermentau River had shorter, narrower (leaf-shaped) rostra and asymmetrical (conspicuously heterocercal) caudal lobes. Those from the Tombigbee River had longer, broader (spoon-shaped) rostra and more symmetrical caudal lobes. Those from the Mississippi River had the longest, broadest (paddle-shaped) rostra and symmetrical (superficially "homocercal") caudal lobes. Locality-based gradient in paddlefish morphology corresponds to a gradient in river hydrology: longer, broader rostra and symmetrical caudal lobes were associated with larger basins, higher gradients, and greater discharge. C1 [Hoover, Jan Jeffrey; Boysen, Krista A.; Murphy, Catherine E.; George, Steven G.] USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Hoover, JJ (reprint author), USA, Engineer Res & Dev Ctr, Waterways Expt Stn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jan.j.hoover@usace.army.mil NR 44 TC 3 Z9 3 U1 1 U2 2 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE, STE 110, BETHESDA, MD 20814-2199 USA SN 0892-2284 BN 978-1-934874-12-7 J9 AM FISH S S PY 2009 VL 66 BP 157 EP 171 PG 15 WC Fisheries SC Fisheries GA BPB75 UT WOS:000278471300010 ER PT J AU Cohen, SP Dragovich, A Larkin, TM AF Cohen, Steven P. Dragovich, Anthony Larkin, Thomas M. TI Dehydration: Cause of Acute Renal Failure RESPONSE SO PAIN PHYSICIAN LA English DT Letter ID EVENTS C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Baltimore, MD 20205 USA. [Cohen, Steven P.; Dragovich, Anthony] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Dragovich, Anthony] Womack Army Med Ctr, Ft Bragg, NC 28307 USA. [Larkin, Thomas M.] Pkwy Neurosci & Spine Inst, Hagerstown, MD 21740 USA. RP Cohen, SP (reprint author), Johns Hopkins Sch Med, Baltimore, MD 20205 USA. EM scohen40@jhmi.edu; larkintm@comcast.net NR 8 TC 0 Z9 0 U1 0 U2 0 PU AM SOC INTERVENTIONAL PAIN PHYSICIANS PI PADUCAH PA 81 LAKEVIEW DR, PADUCAH, KY 42001 USA SN 1533-3159 J9 PAIN PHYSICIAN JI Pain Physician PD JAN-FEB PY 2009 VL 12 IS 1 BP 282 EP 282 PG 1 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 406SC UT WOS:000263314200016 ER PT J AU Lee, JK Grace, KA Taylor, AJ AF Lee, Jeannie K. Grace, Karen A. Taylor, Allen J. TI Ten lessons learned from conducting an adherence intervention trial SO PATIENT PREFERENCE AND ADHERENCE LA English DT Article DE adherence; pharmacist; intervention; medication AB Clinical practice research provides a unique opportunity to care for a diverse patient population in various health care system settings. Federal study of Adherence to Medications in the Elderly (FAME) was the first prospective observational and randomized controlled trial to implement effective strategies to enhance medication adherence and health outcomes in older patients using polypharmacy. Ten lessons learned from conducting this adherence intervention trial are described: (1) Link the trial to existing clinical work, (2) Begin with a thorough understanding of medication adherence, (3) Ensure that trial highlights individualized intervention, (4) Tailor inclusion criteria and study duration to target population, (5) Employ a range of outcomes linked to meaningful clinical effects, (6) Win the support of the multidisciplinary team and the administration, (7) Promote team work, (8) Consider the potential limitations, (9) Seize the grant opportunities, and (10) Share the findings. C1 [Lee, Jeannie K.] Univ Arizona, Coll Pharm, Dept Pharm Practice & Sci, Tucson, AZ 85721 USA. Walter Reed Army Med Ctr, Dept Pharm, Washington, DC 20307 USA. [Grace, Karen A.; Taylor, Allen J.] Washington Hosp Ctr, Div Cardiol, Washington, DC 20010 USA. RP Lee, JK (reprint author), Univ Arizona, Coll Pharm, Dept Pharm Practice & Sci, 1295 N Martin Ave,POB 210202, Tucson, AZ 85721 USA. EM jlee@pharmacy.arizona.edu NR 19 TC 1 Z9 1 U1 0 U2 3 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1177-889X J9 PATIENT PREFER ADHER JI Patient Prefer. Adherence PY 2009 VL 3 BP 93 EP 98 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V21NU UT WOS:000208215100012 PM 19936150 ER PT B AU Eastman, R Hong, T Shi, J Hanning, T Muralikrishnan, B Young, SS Chang, T AF Eastman, Roger Hong, Tsai Shi, Jane Hanning, Tobias Muralikrishnan, Bala Young, S. Susan Chang, Tommy BE Madhavan, R Tubstel, E Messina, E TI Performance Evaluation and Metrics for Perception in Intelligent Manufacturing SO PERFORMANCE EVALUATION AND BENCHMARKING OF INTELLIGENT SYSTEMS LA English DT Proceedings Paper CT Workshop on Performance Metrics for Intelligent Systems (PerMIS 08) CY AUG 19-21, 2008 CL Natl Inst Stand, Gaithersburg, MD HO Natl Inst Stand AB An unsolved but important problem in intelligent manufacturing is dynamic pose estimation under complex environmental conditions-tracking an object's pose and position as it moves in an environment with uncontrolled lighting and back-round. This is a central task in robotic perception, and a robust, highly accurate solution would be of use in a number of manufacturing applications. To be commercially feasible, a solution must also be benchmarked against performance standards so manufacturers fully understand its nature and capabilities. The PerMIS 2008 Special Session on "Performance Metrics for Perception in Intelligent Manufacturing," held August 20, 2008, brought together academic, industrial and governmental researchers interested in calibrating and benchmarking vision and metrology systems. The special session had a series of speakers who each addressed a component of the general problem of benchmarking complex perception tasks, including dynamic pose estimation. The components included assembly line motion analysis, camera calibration, laser tracker calibration, super-resolution range data enhancement and evaluation, and evaluation of 6DOF pose estimation for visual servoing. This Chapter combines and summarizes the results of the special session, giving a framework for benchmarking perception systems and relating the individual components to the general framework. C1 [Eastman, Roger] Loyola Univ, Baltimore, MD 21210 USA. [Hong, Tsai; Muralikrishnan, Bala; Chang, Tommy] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Shi, Jane] Gen Motors Res & Dev, Warren, MI 48090 USA. [Hanning, Tobias] Univ Passau, Passau, Germany. [Young, S. Susan] Army Res Lab, Adelphi, MD 20783 USA. RP Eastman, R (reprint author), Loyola Univ, Baltimore, MD 21210 USA. EM reastman@loyola.edu; jane.shi@gm.com NR 38 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-0491-1 PY 2009 BP 269 EP + DI 10.1007/978-1-4419-0492-8_12 PG 4 WC Computer Science, Artificial Intelligence SC Computer Science GA BMM54 UT WOS:000272813500012 ER PT B AU Schlenker, BR Miller, ML Johnson, RM AF Schlenker, Barry R. Miller, Marisa L. Johnson, Ryan M. BE Narvaez, D Lapsley, DK TI Moral Identity, Integrity, and Personal Responsibility SO PERSONALITY, IDENTITY, AND CHARACTER: EXPLORATIONS IN MORAL PSYCHOLOGY LA English DT Article; Book Chapter ID TRIANGLE MODEL; SELF; CONCEPTIONS; COMMITMENT; BEHAVIOR; CHARACTER; JUDGMENT; EXCUSES; IMPACT C1 [Schlenker, Barry R.; Johnson, Ryan M.] Univ Florida, Gainesville, FL 32611 USA. [Miller, Marisa L.] USA, Res Inst, Ft Benning, GA USA. RP Schlenker, BR (reprint author), Univ Florida, Gainesville, FL 32611 USA. NR 60 TC 11 Z9 11 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-71927-8 PY 2009 BP 316 EP 340 DI 10.1017/CBO9780511627125.015 D2 10.1017/CBO9780511627125 PG 25 WC Psychology, Social SC Psychology GA BBS96 UT WOS:000308085600015 ER PT J AU Durst, HD Rohrbaugh, DK Munavalli, S AF Durst, H. D. Rohrbaugh, D. K. Munavalli, S. TI Microwave-Assisted Reaction of Dimethyl H-Phosphonate with Cyclohexene and Alkene Oxides SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE Butyl and decyl derivatives; cyclohexyl; deoxygenation; diastereomeric phosphonates and pyrophosphates; dimethyl H-phosphonate; free radical reaction; mass spectral breakdown behavior ID ORGANOPHOSPHORUS COMPOUNDS; ORGANIC-SYNTHESIS; STYRENE OXIDE; ARENE OXIDES; EPOXIDES; CHEMISTRY; OXIDATION; ESTERS; REARRANGEMENT; ACTIVATION AB Microwave-assisted reaction of dimethyl H-phosphonate with cyclohexene-, 1,2-butene-, and 1,2-decene oxides furnishes 8, 5, and 17 compounds, respectively. The probable mechanism of the formation of the various compounds via free radical reactions and their GC-MS characterization are presented in this article. C1 [Munavalli, S.] SAIC, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. [Durst, H. D.; Rohrbaugh, D. K.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Munavalli, S (reprint author), SAIC, Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM shekar.munavalli@us.army.mil NR 64 TC 1 Z9 1 U1 0 U2 5 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PY 2009 VL 184 IS 10 BP 2680 EP 2696 DI 10.1080/10426500802561419 PG 17 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 596MV UT WOS:000277690200022 ER PT J AU Durst, HD Rohrbaugh, DK Munavalli, S AF Durst, H. D. Rohrbaugh, D. K. Munavalli, S. TI Stereoselective Synthesis of Phosphoryl Derivatives SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE Alkylphosphinates; dialkylphosphites; mass spectral characterization; Michaelis-Arbuzov reaction; stereoselectivity ID H-DIMETHYLPHOSPHONATE; RING PHOSPHITES; ESTERS; STEREOCHEMISTRY; CHEMISTRY; SALTS AB The reaction of dialkylphosphonites with N-(bromomethyl) phthalimide furnishes alkyl phenyl hydrogenphosphinates, dialkyl phenylphosphonates, and N[(bromomethyl)phthalimido)]-phosphinates. The stereoselectivity of the primary product of the reaction appears to increase with the increasing size of the groups attached to the phosphorus atom. C1 [Munavalli, S.] SAIC, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. [Durst, H. D.; Rohrbaugh, D. K.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. RP Munavalli, S (reprint author), SAIC, Gunpowder Branch, POB 68, Aberdeen Proving Ground, MD 21010 USA. EM shekar.munavalli@yahoo.com NR 32 TC 2 Z9 3 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PY 2009 VL 184 IS 11 BP 2902 EP 2909 DI 10.1080/10426500802591655 PG 8 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 596MZ UT WOS:000277690600013 ER PT J AU Munavalli, S Rohrbaugh, DK Durst, HD AF Munavalli, S. Rohrbaugh, D. K. Durst, H. D. TI Interesting Transformations of Thiocamphor SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE GC-MS; mass spectrometry; pathway; radicals ID THIOCARBONYL COMPOUNDS; THIOKETONES; CONVERSION; MILD AB Thiocamphor has been found to furnish bornane, camphor, isoborneol, isobornylthiol, bornylthiol, tetrahydro-bis-(1,7,7-trimethylbicyclo[2.2.1]heptyl)-3,3'-disulfide, and three isomeric bis-(1,7,7-trimethylbicyclo[2.2.1]heptyl)-3,3'-dithiols when treated with NaBH(4) either in dry THF or dry diethylene glycol diethyl ether. The origins of the above interesting compounds and their mass spectral characterization are presented in this article. C1 [Munavalli, S.] Sci Applicat Int Corp, Edgewood, MD 21010 USA. [Rohrbaugh, D. K.; Durst, H. D.] USA, Edgewood Chem & Biol Ctr, APG, Edgewood, MD USA. RP Munavalli, S (reprint author), Sci Applicat Int Corp, POB 68, Edgewood, MD 21010 USA. EM shekar.munavalli@yahoo.com NR 15 TC 0 Z9 0 U1 2 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1042-6507 J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PY 2009 VL 184 IS 11 BP 2989 EP 2995 DI 10.1080/10426500802625743 PG 7 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA 596MZ UT WOS:000277690600020 ER PT S AU Reed, ML Readinger, ED Moe, CG Shen, H Wraback, M Syrkin, A Usikov, A Kovalenkov, OV Dmitriev, VA AF Reed, M. L. Readinger, E. D. Moe, C. G. Shen, H. Wraback, M. Syrkin, A. Usikov, A. Kovalenkov, O. V. Dmitriev, V. A. BE Stutzmann, M Stolz, H TI Benefits of negative polarization charge in n-InGaN on p-GaN single heterostructure light emitting diode with p-side down SO PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 6, NO 2 SE Physica Status Solidi C-Current Topics in Solid State Physics LA English DT Proceedings Paper CT 9th International Workshop on Nonlinear Optics and Excitation Kinetics in Semiconductors CY MAY 26-29, 2008 CL Klink, GERMANY ID MULTIPLE-QUANTUM WELLS; FIELDS AB The effects of negative polarization charge at the n-InGaN/pGaN interface on the performance of hydride vapour phase epitaxy-deposited single heterostructure n-In0.17Ga0.83N/p-GaN light emitting diodes with p-side down are investigated. The negative polarization charge at the interface leads to the formation of a two-dimensional hole gas within the InGaN near the n-InGaN/p-GaN interface, as well as reducing the barrier for hole injection. In addition, electrons encounter experience a significant barrier for injection across the heterointerface. As a result, superlinear increase in light output as injection current increases below 20 A/cm(2) and peak emission wavelength shift from 495 nm to 470 nm are observed. We show that the combination of two-dimensional hole-gas formation on the n-InGaN side of the hetero-interface and enhancement of the electron barrier to transport across this interface may reduce efficiency droop at high current density without the need for an AlGaN electron blocking layer. (C) 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Reed, M. L.; Readinger, E. D.; Moe, C. G.; Shen, H.; Wraback, M.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Syrkin, A.; Usikov, A.; Kovalenkov, O. V.; Dmitriev, V. A.] Technol & Devices Int Inc, Silver Spring, MD 20904 USA. RP Reed, ML (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM Meredith.L.Reed@arl.army.mil FU U.S. Department of Energy Solid State LightingProgram FX TDI, Inc. gratefully acknowledges the support of the U.S. Department of Energy Solid State LightingProgram. NR 15 TC 4 Z9 8 U1 0 U2 6 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY SN 1862-6351 J9 PHYS STATUS SOLIDI C PY 2009 VL 6 IS 2 BP 585 EP + DI 10.1002/pssc.200880401 PG 2 WC Optics; Physics, Applied SC Optics; Physics GA BJD25 UT WOS:000264882800049 ER PT S AU Garrett, GA Shen, HE Wraback, M Tyagi, A Schmidt, MC Speck, JS DenBaars, SP Nakamaura, S AF Garrett, Gregory A. Shen, Hongen Wraback, Michael Tyagi, Anurag Schmidt, Mathew C. Speck, James S. DenBaars, Steven P. Nakamaura, Shuji BE Butte, R TI Comparison of time-resolved photoluminescence from InGaN single quantum wells grown on nonpolar and semipolar bulk GaN substrates SO PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 6, SUPPL 2 SE Physica Status Solidi C-Current Topics in Solid State Physics LA English DT Proceedings Paper CT International Workshop on Nitride Semiconductors CY OCT 06-10, 2008 CL Montreux, SWITZERLAND AB Single quantum wells of low InN concentration InGaN grown on high quality nonpolar and semipolar substrates cut from bulk GaN boules are studied by time-resolved photoluminescence techniques. Data is presented for different well widths at varying pump fluence and sample temperature to study nonlinear non-radiative recombination, radiative lifetimes, and carrier localization or separation. (C) 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Garrett, Gregory A.; Shen, Hongen; Wraback, Michael] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Tyagi, Anurag; Schmidt, Mathew C.; Speck, James S.; DenBaars, Steven P.; Nakamaura, Shuji] Univ Calif Santa Barbara, Elect & Comp Engn & Mat, Santa Barbara, CA 93106 USA. RP Garrett, GA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gregory.a.garrett@us.army.mil RI Speck, James/H-5646-2011 NR 5 TC 24 Z9 24 U1 1 U2 11 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY SN 1862-6351 J9 PHYS STATUS SOLIDI C PY 2009 VL 6 BP S800 EP S803 DI 10.1002/pssc.200880974 PN S2 PG 4 WC Optics; Physics, Applied; Physics, Condensed Matter SC Optics; Physics GA BWQ45 UT WOS:000294494400128 ER PT S AU Metcalfe, GD Readinger, ED Shen, HE Woodward, NT Dierolf, V Wraback, M AF Metcalfe, Grace D. Readinger, Eric D. Shen, Hongen Woodward, Nathaniel T. Dierolf, Volkmar Wraback, Michael BE Butte, R TI Energy levels of Nd3+ ions in GaN SO PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 6, SUPPL 2 SE Physica Status Solidi C-Current Topics in Solid State Physics LA English DT Proceedings Paper CT International Workshop on Nitride Semiconductors CY OCT 06-10, 2008 CL Montreux, SWITZERLAND ID ROOM-TEMPERATURE; IMPLANTED GAN; DOPED GAN; PHOTOLUMINESCENCE; SPECTROSCOPY AB We report the Stark energy sublevels of Nd3+ ions in GaN grown by plasma-assisted molecular beam epitaxy as determined by luminescence spectra. The photoluminescence spectra is correlated with transitions from the F-4(3/2) doublet state to the I-4(9/2), I-4(11/2), and I-4(13/2) multiplets of the Nd3+ ion for above and below bandgap excitation, with the strongest emission occurring at 1.12 eV (1106 nm). A splitting of the F-4(3/2) excited state is determined to be 4.1 meV. From photoluminescence excitation spectra, we also identify the Stark sublevels of the excited states F-4(5/2), H-2(9/2), F-4(7/2), S-4(3/2), (2)G(7/2), and (4)G(5/2). Photoluminescence excitation spectra exhibit an optimal excitation energy of 1.48 eV (836 nm). Site-selective spectroscopy studies using combined excitation-emission spectroscopy with confocal microscopy imply enhanced substantial doping at the Ga site. In addition, optical loss and gain measurements of a GaN:Nd waveguide excited above bandgap indicate an internal loss coefficient of similar to 6.5 +/-2 cm(-1) and a net gain of similar to -2 +/- 2 cm(-1). (C) 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Metcalfe, Grace D.; Readinger, Eric D.; Shen, Hongen; Wraback, Michael] USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Woodward, Nathaniel T.; Dierolf, Volkmar] Lehigh Univ, Dept Phys, Bethlehem, PA 18015 USA. RP Metcalfe, GD (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.metcalfe@us.army.mil; eric.readinger@us.army.mil NR 14 TC 2 Z9 2 U1 1 U2 5 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY SN 1862-6351 J9 PHYS STATUS SOLIDI C PY 2009 VL 6 BP S671 EP S674 DI 10.1002/pssc.200880953 PN S2 PG 4 WC Optics; Physics, Applied; Physics, Condensed Matter SC Optics; Physics GA BWQ45 UT WOS:000294494400096 ER PT J AU Podeszwa, R Rice, BM Szalewicz, K AF Podeszwa, Rafal Rice, Betsy M. Szalewicz, Krzysztof TI Crystal structure prediction for cyclotrimethylene trinitramine (RDX) from first principles SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS LA English DT Article ID DENSITY-FUNCTIONAL THEORY; POTENTIAL-ENERGY SURFACE; AB-INITIO; PENTAERYTHRITOL TETRANITRATE; BENZENE DIMER; HMX AB Crystal structure prediction and molecular dynamics methods were applied to the cyclotrimethylene trinitramine (RDX) crystal to explore the stability rankings of various polymorphs using a recently developed nonempirical potential energy function that describes the RDX dimer interactions. The energies of 500 high-density structures resulting from molecular packing were minimized and the 14 lowest-energy structures were subjected to isothermal-isostress molecular dynamics (NsT-MD) simulations. For both crystal structure prediction methods and molecular dynamics simulations, the lowest-energy polymorph corresponded to the experimental structure; furthermore, the lattice energy of this polymorph was lower than that of the other polymorphs by at least 1.1 kcal mol(-1). Crystal parameters and densities of the low-energy crystal produced by the NsT-MD simulations matched those of the experimental crystal to within 1% of density and cell edge lengths and 0.01 degrees of the cell angle. The arrangement of the molecules within the time-averaged unit cell were in equally outstanding agreement with experiment, with the largest deviation of the location of the molecular mass centers being less than 0.07 angstrom and the largest deviation in molecular orientation being less than 2.8 degrees. NsT-MD simulations were also used to calculate crystallographic parameters as functions of temperature and pressure and the results were in a reasonable agreement with experiment. C1 [Podeszwa, Rafal] Silesian Univ, Inst Chem, PL-40006 Katowice, Poland. [Podeszwa, Rafal; Szalewicz, Krzysztof] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA. [Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Podeszwa, R (reprint author), Silesian Univ, Inst Chem, Szkolna 9, PL-40006 Katowice, Poland. FU ARO DEPSCOR; NSF [CHE-0555979]; Polish Science Foundation; Office of Naval Research FX This research was supported by an ARO DEPSCOR grant, by NSF grant CHE-0555979, by the Polish Science Foundation grant Homing and the Office of Naval Research. Most of the calculations were performed using computer resources allocated by a DoD HPCMP Challenge Project. NR 31 TC 34 Z9 34 U1 1 U2 24 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1463-9076 J9 PHYS CHEM CHEM PHYS JI Phys. Chem. Chem. Phys. PY 2009 VL 11 IS 26 BP 5512 EP 5518 DI 10.1039/b902015b PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 461VJ UT WOS:000267300000035 PM 19551222 ER PT J AU Gerber, JP Marcus, RL Dibble, LE Greis, PE Burks, RT LaStayo, PC AF Gerber, J. Parry Marcus, Robin L. Dibble, Leland E. Greis, Patrick E. Burks, Robert T. LaStayo, Paul C. TI Effects of Early Progressive Eccentric Exercise on Muscle Size and Function After Anterior Cruciate Ligament Reconstruction: A 1-Year Follow-up Study of a Randomized Clinical Trial SO PHYSICAL THERAPY LA English DT Article ID PATELLAR TENDON; NEGATIVE WORK; STRENGTH; KNEE; REHABILITATION; AUTOGRAFTS; MORPHOLOGY; ERGOMETRY; SURGERY; HUMANS AB Background and Purpose. The authors previously reported that focused eccentric resistance training during the first 15 weeks following anterior cruciate ligament reconstruction (ACL-R) induced greater short-term increases in Muscle Volume, strength, and measures of function relative to standard rehabilitation. The purpose of this study was to evaluate the effects of early progressive eccentric exercise on muscle volume,and function at 1 year after ACL-R. Participants and Methods. Forty patients who had undergone an ACL-R were randomly assigned to 1 of 2 groups: a group that received early progressive eccentric exercise (n=20) and a group that received standard rehabilitation (n=20). Seventeen participants in the eccentric exercise group and 15 participants in the standard rehabilitation group completed a 1-year follow-up. Magnetic resonance images of the thighs were acquired 1 year after ACL-R and compared with images acquired 3 weeks after surgery. Likewise, routine knee examinations, self-report assessments, and strength and functional testing were completed 1 year after surgery and compared with previous evaluations. A 2-factor analysis of variance for repeated measures (group X time) was used to analyze the data. Results. Compared with the standard rehabilitation group, improvements in quadriceps femoris and gluteus maximus muscle volume in the involved lower extremity from 3 weeks to 1 year following ACL-R were significantly greater in the eccentric exercise group. Improvements in quadriceps femoris and gluteus maximus muscle volume were 23.3% (SD=14.1%) and 20.6% (SD=12.9%), respectively, in the eccentric exercise group and 13.4% (SD=10.3%) and 11.6% (SD=10.4%), respectively, in the standard rehabilitation group. Improvements in quadriceps femoris muscle strength and hopping distance also were significantly greater in the eccentric exercise group 1 year postsurgery. Discussion and Conclusions. A 12-week focused eccentric resistance training program, implemented 3 -weeks after ACL-R, resulted in greater increases in quadriceps femoris and gluteus maximus muscle Volume and function compared with standard rehabilitation at 1 year following ACL-R. C1 [Gerber, J. Parry] US Mil Baylor Univ, US Mil Acad, Postgrad Sports Med Residency Program, US Mil Acad,Keller Army Community Hosp, West Point, NY 10996 USA. [LaStayo, Paul C.] Univ Utah, Dept Phys Therapy, Dept Exercise & Sport Sci, Salt Lake City, UT USA. [Greis, Patrick E.; Burks, Robert T.; LaStayo, Paul C.] Univ Utah, Dept Orthoped, Salt Lake City, UT USA. RP Gerber, JP (reprint author), US Mil Baylor Univ, US Mil Acad, Postgrad Sports Med Residency Program, US Mil Acad,Keller Army Community Hosp, West Point, NY 10996 USA. EM john.Gerber@us.army.mil FU American Physical Therapy Association FX This study was funded, in part, by the American Physical Therapy Association Orthopedic Section Clinical Research Grant to Dr Gerber and Dr LaStayo. NR 33 TC 49 Z9 52 U1 0 U2 5 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD JAN PY 2009 VL 89 IS 1 BP 51 EP 59 DI 10.2522/ptj.20070189 PG 9 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 389FJ UT WOS:000262076300005 PM 18988664 ER PT J AU Dreyfuss, P Cohen, S Chen, AS Bohart, Z Bogduk, N AF Dreyfuss, Paul Cohen, Steven Chen, Allen Sinclair Bohart, Zach Bogduk, Nikolai TI Is Immediate Pain Relief After a Spinal Injection Procedure Enhanced by Intravenous Sedation? SO PM&R LA English DT Article AB Objective: To determine the effect of intravenous sedation on postprocedural pain relief for patients undergoing a spinal injection procedure in which there is no expectation of immediate relief. Design: A prospective audit to compare Visual Analog Scale (VAS) responses before and after interlaminar epidural corticosteroid injections without epidural anesthetic in those who did and did not receive intravenous sedation. Setting: This audit was undertaken in 2 interventional spine practices. Patients: A total of 102 patients were allotted to receive or not receive intravenous sedation depending on preference. Interventions: Inter laminar epidural injections of corticosteroid without epidural anesthetic. Main Outcome Measurements: Outcomes were measured by mean (VAS) scores after the procedure and mean VAS differences before and after the procedure. Results: There were no significant differences between mean VAS scores or mean differences in VAS scores between those who did or did not receive intravenous sedation. A relatively high percentage of patients in both groups obtained greater than 50% immediate pain relief. Conclusion: Intravenous mild or moderate conscious sedation did not have an effect on postprocedural VAS pain scores in those receiving a therapeutic spinal injection procedure. Immediate pain relief was most likely the result of nonspecific effects. C1 [Dreyfuss, Paul] Univ Washington, Dept Rehabil Med, Bellevue, WA 98004 USA. [Cohen, Steven] Johns Hopkins Sch Med, Dept Anesthesia & Crit Care Med, Baltimore, MD USA. [Cohen, Steven] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Chen, Allen Sinclair; Bohart, Zach] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. [Bogduk, Nikolai] Univ Newcastle, Royal Newcastle Hosp, Dept Clin Res, Callaghan, NSW 2308, Australia. RP Dreyfuss, P (reprint author), Univ Washington, Dept Rehabil Med, 12301 NE 10th Pl,Suite 101, Bellevue, WA 98004 USA. EM pauldreyfuss@gmail.com NR 12 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1934-1482 J9 PM&R JI PM&R PD JAN PY 2009 VL 1 IS 1 BP 60 EP 63 DI 10.1016/j.pmrj.2008.10.006 PG 4 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA V24LD UT WOS:000208411000010 PM 19627874 ER PT S AU Felton, M Gurton, KP Roth, LE Pezzaniti, JL Chenault, DB AF Felton, M. Gurton, K. P. Roth, L. E. Pezzaniti, J. L. Chenault, D. B. BE Shaw, JA Tyo, JS TI Measured comparison of the inversion periods for polarimetric and conventional thermal long-wave IR (LWIR) imagery SO POLARIZATION SCIENCE AND REMOTE SENSING IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Polarization Science and Remote Sensing IV CY AUG 03-04, 2009 CL San Diego, CA SP SPIE DE Polarimetric imaging; thermal imaging; microbolometer; target contrast; inversion periods AB We report the results of a multi-day diurnal study in which radiometrically calibrated polarimetric and conventional thermal imagery is recorded in the LWIR to identify/compare the respective time periods in which minimum target contrast is achieved, e. g., thermal inversion periods are typically experienced during dusk and dawn. Imagery is recorded with a polarimetric IR sensor employing a 324x256 microbolometer array using a spinning achromatic retarder to perform the polarimetric filtering. The images used in this study include the S-0, normalized S-1, and normalized S-2 Stokes images and the degree of linear polarization (DOLP) images of a scene containing military vehicles and the natural background. In addition, relevant meteorological parameters measured during the test period include air temperature, ambient loading in the LWIR, relative humidity, and cloud cover, height and density. The data shows that the chief factors affecting polarimetric contrast are the amount of thermal emission from the objects in the scene and the abundance of LWIR sources in the optical background. In addition, we found that contrast between targets and background within polarimetric images often remains relatively high during periods of low thermal contrast. C1 [Felton, M.; Gurton, K. P.] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Roth, L. E.] USA, Armament Res & Dev Engn Ctr, Picatinny Arsenal, NJ 07806 USA. [Pezzaniti, J. L.; Chenault, D. B.] Polaris Sensor Technol Inc, Huntsville, AL 35801 USA. RP Felton, M (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mfelton@arl.army.mil NR 6 TC 3 Z9 3 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7751-4 J9 PROC SPIE PY 2009 VL 7461 AR UNSP 74610A DI 10.1117/12.825355 PG 13 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BCJ99 UT WOS:000310357000009 ER PT S AU Gurton, KP Felton, M AF Gurton, Kristan P. Felton, Melvin BE Shaw, JA Tyo, JS TI Detection of disturbed earth using passive LWIR polarimetric imaging SO POLARIZATION SCIENCE AND REMOTE SENSING IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Polarization Science and Remote Sensing IV CY AUG 03-04, 2009 CL San Diego, CA SP SPIE ID MINE DETECTION; ROC ANALYSIS; SENSORS AB We report test results of a study to assess the applicability for using passive polarimetric imaging in the long-wave infrared (LWIR) to detect regions of recently altered road-type surfaces, e.g., soil, gravel, asphalt, etc. The field test was conducted at the U.S. Army Research Laboratory, Adelphi, MD, on a test surface best described as a well traveled dirt road consisting of a gravel clay-soil mixture that was well compacted. During this initial proof-of-concept test, a LWIR polarimetric camera system was positioned at a slant-path of 10 degrees with respect to the line-of-site (LOS) and the natural lay of the surface, approximately 15 meters from the target test-bed. Stokes images, S0, S1, and S2, were recorded using the LWIR polarimeter that utilizes a spinning achromatic retarder design mated to Mercury Cadmium Telluride (MCT) focal plane array (FPA). Various surrogate targets were buried near the surface and great care was taken to camouflage the area to eliminate any "visible" signs of disturbance. Thermal gradients resulting from the unearthing of cool soil were allowed to dissipate. Two metrics were used to evaluate performance, i.e., conventional receiver operating characteristic (ROC) curve analysis and an effective contrast ratio between the target and background. Results showed particularly good detectability in the S2 imagery, with less in S1, and no detectability in S0, i.e., the conventional LWIR thermal image. C1 [Gurton, Kristan P.; Felton, Melvin] USA, Res Lab, Adelphi, MD 20783 USA. RP Gurton, KP (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 25 TC 1 Z9 1 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7751-4 J9 PROC SPIE PY 2009 VL 7461 AR 746115 DI 10.1117/12.837779 PG 15 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BCJ99 UT WOS:000310357000033 ER PT S AU Bruno, FF Belton, LE Sleeves, DM AF Bruno, Ferdinando F. Belton, Lauren E. Sleeves, Diane M. BE Bauer, S Cheng, Z Wrobleski, DA Zhang, Q TI Novel Enzymatic Polymerization of Diazo Compounds: A New Group of Dyes SO POLYMER-BASED SMART MATERIALS - PROCESSES, PROPERTIES AND APPLICATION SE Materials Research Society Symposium Proceedings LA English DT Proceedings Paper CT Symposium on Polymer-Based Materials held at the 2008 MRS Fall Meeting CY DEC 02-05, 2008 CL Boston, MA SP Mat Res Soc ID PEROXIDASE; POLYMERS AB The homopolymerization of Sudan Orange G, Disperse Orange 3, Calcon, Mordant Yellow 12, Disperse Orange 13, and Bismarck Brown Y, was mediated by the enzyme horseradish peroxidase. Fourier transform infrared (FTIR) spectroscopy and matrix assisted time-of-flight mass spectrometry (MALDI-TOF) was utilized to confirm the polymeric structures. The enzymatic reaction produced novel electroluminescent polymers that exhibit a red or a blue shift, and enhanced non-linear optical behavior when compared to the corresponding monomers. The results of detailed optical analysis of the polymeric materials will be presented. C1 [Bruno, Ferdinando F.; Belton, Lauren E.; Sleeves, Diane M.] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Bruno, FF (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. NR 9 TC 0 Z9 0 U1 1 U2 2 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DRIVE, WARRENDALE, PA 15088-7563 USA SN 0272-9172 BN 978-1-60511-106-3 J9 MATER RES SOC SYMP P PY 2009 VL 1134 BP 91 EP 96 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Polymer Science SC Science & Technology - Other Topics; Materials Science; Polymer Science GA BMR07 UT WOS:000273375700014 ER PT B AU Albert, DG Decato, SN Perron, FE AF Albert, D. G. Decato, S. N. Perron, F. E., Jr. BE Ling, HI Smyth, A Betti, R TI Experimental Measurements of the Biot Slow Wave in Natural Snow Covers SO PORO-MECHANICS IV LA English DT Proceedings Paper CT 4th Biot Conference on Poromechanics CY JUN 08-10, 2009 CL Columbia Univ, New York, NY SP Columbia Univ, Sch Engn & Appl Sci, Univ Oklahoma, Poromechan Inst, ASCE Engn Mech Inst, ADAMA Engn, ERG Construct Trade & Ins Co Inc HO Columbia Univ ID OUTDOOR SOUND-PROPAGATION; ABSORPTION; FREQUENCY AB The quiet conditions produced by a snow cover on the ground have been noticed by many observers, but few have realized that the sound attenuation is caused by Biot slow waves induced into this highly porous material. We present a measurement illustrating this attenuation for a surface microphone in the presence of a thin seasonal snow cover, then discuss a separate measurement on a thick snow cover designed to confirm the presence of the Biot slow wave by determining its velocity. The latter measurements used vertical sledge hammer blows and blank pistol shots to generate horizontally propagating waves 69 meters from the acoustic (microphone) and seismic (geophone) sensor location. For both sources, seismic P1 compressional, shear, and Rayleigh waves are visible on the measured time series, followed by the airborne acoustic arrival. The acoustic arrival generates additional P1 ice frame waves and Biot P2 slow waves that propagate downward from the snow surface at measured velocities of 460 and 95 m/s, respectively. By comparing the measured waveforms with theoretical calculations for a rigid porous medium, the Biot P2 slow wave can account for the distortion and attenuation visible in the atmospheric acoustic wave. The agreement can be used to determine snow permeability, a parameter otherwise hard to measure on natural snow, and for shallow snow covers this procedure also provides an accurate estimate of snow cover depth. Separate small scale laboratory measurements show that the P2 wave in snow is dispersed (the velocity increases with increasing frequency) in agreement with the trend predicted by Biot's theory, but with some parameter adjustments needed to obtain the best agreement. C1 [Albert, D. G.; Decato, S. N.; Perron, F. E., Jr.] ERDC CRREL, Hanover, NH 03755 USA. RP Albert, DG (reprint author), ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. NR 19 TC 1 Z9 1 U1 1 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-006-8 PY 2009 BP 724 EP 729 PG 6 WC Materials Science, Multidisciplinary; Mechanics; Physics, Fluids & Plasmas SC Materials Science; Mechanics; Physics GA BLG88 UT WOS:000270143600109 ER PT S AU Cole, DM Hopkins, MA AF Cole, David M. Hopkins, Mark A. BE Nakagawa, M Luding, S TI Contact Mechanics of Naturally Occurring Grains: Experiments and Discrete Element Modeling SO POWDERS AND GRAINS 2009 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 6th International Conference on the Micromechanics of Granular Media CY JUL 13-17, 2009 CL Golden, CO SP Assoc Study Micromech Granular Media, Univ Twente, Colorado Sch Mines DE Contact mechanics; experiments; geologic materials; discrete element modeling AB Application of the discrete element method to engineering problems involving naturally occurring granular materials requires knowledge of the contact mechanics of the particles and a realistic treatment of particle shapes. This paper presents results from on-going work that addresses these two fundamental issues of granular media mechanics. Grain-scale laboratory experiments are being conducted to provide the needed contact relationships. A concurrent discrete element modeling effort is under way to implement the experimentally determined contact relationships and employ realistic particle shapes. The experiments determine the stiffness and frictional behavior of normal and sliding contacts of observed for spherical specimens of gneiss. Stiffness in the normal mode is seen to range from 0.1 to 15 MN m(-1) depending on force level. Shear stiffness is on the order of the normal stiffness, but only for relatively low shear force levels (or shear deformations). Frictional energy losses are observed to varying degrees under virtually all experimental conditions. The discrete element modeling effort simulates the triaxial response of the spherical grains enclosed in a membrane and implements the experimentally determined contact relationships for normal and sliding contact behavior. Inclusion of the full frictional behavior prior to macroscopic sliding is under development. Some aspects of the simulations of the triaxial deformation of spherical grains of gneiss are presented and compared with the grain-scale experimental data. The simulations are seen to capture the key features of the experimental observations. C1 [Cole, David M.; Hopkins, Mark A.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Cole, DM (reprint author), USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. NR 10 TC 4 Z9 4 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0682-7 J9 AIP CONF PROC PY 2009 VL 1145 BP 351 EP 354 PG 4 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA BLN80 UT WOS:000270602900077 ER PT J AU Holcomb, J McManus, J Kerr, ST Pusateri, A AF Holcomb, John B. McManus, John G. Kerr, S. T. Pusateri, Anthony E. TI Needle versus Tube Thoracostomy in a Swine Model of Traumatic Tension Hemopneumothorax SO Prehospital Emergency Care LA English DT Article DE tension pneumothorax; tube thoracostomy; needle thoracostomyn ID INSUFFICIENT CANNULA LENGTH; CHEST-WALL THICKNESS; POTENTIAL FAILURE; PNEUMOTHORAX; THORACENTESIS AB Objective. Traumatic tension hemopneumothorax is fatal if not treated rapidly. However, whether prehospital decompression is better achieved by chest tube or needle thoracostomy is unknown. We conducted this study to compare the immediate results and prolonged effectiveness of two methods of treatment for traumatic tension hemopneumothorax in a swine model. Methods. Ten percent of calculated total blood volume was instilled into the hemithorax of spontaneously ventilating swine (n = 5 per group, 40 3 kg). A Veres needle and insufflator were used to induce tension hemopneumothorax. Animals were randomized to one of four groups: 1) needle thoracostomy with 14-gauge intravenous catheter; 2) needle thoracostomy with Cook catheter; 3) 32-F chest tube thoracostomy; or 4) no intervention (control). Serial chest x-rays were obtained to document mediastinal shift before and after treatment. Arterial blood gas values and physiologic data were recorded. Postoperatively, thoracoscopy was performed to detect possible pulmonary injury from the procedure and/or catheter kinking or clotting. Results. Positive intrapleural pressure was rapidly relieved in all treated animals. Four-hour survival was 100% in the 14-gauge needle and chest tube thoracostomy groups, 60% in the Cook catheter group, and 0% in the control animals (p 0.05). There were no significant differences in survival or physiologic measurements among the treated animals (p 0.05). Conclusions. In this animal model, needle thoracostomy using a 14-gauge or Cook catheter was as successful as chest tube thoracostomy for relieving tension hemopneumothorax. C1 [Holcomb, John B.; McManus, John G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kerr, S. T.] USN, Med Ctr, San Diego, CA USA. [Pusateri, Anthony E.] Novo Nordisk AS, Princeton, NJ USA. RP Holcomb, J (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.holcomb@amedd.army.mil FU United States Marine Corps FX Supported by a Combat Casualty Care grant from the United States Marine Corps. Cook Catheters were provided by the Cook Group Company. NR 24 TC 16 Z9 16 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PY 2009 VL 13 IS 1 BP 18 EP 27 AR PII 907832556 DI 10.1080/10903120802290760 PG 10 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 394UQ UT WOS:000262476500004 PM 19145520 ER PT J AU McNeil, C McManus, J Mehta, S AF McNeil, Christopher R. McManus, John Mehta, Sumeru TI The Accuracy of Portable Ultrasonography to Diagnose Fractures in an Austere Environment SO Prehospital Emergency Care LA English DT Article DE ultrasound; fracture; postreduction; orthopedic; realignment; austere environment; combat medicine ID SONOGRAPHIC DETECTION; ULTRASOUND DIAGNOSIS; TRAUMA; BONE AB Background. Previous literature has shown the ability of ultrasonography technology to accurately assess orthopedic pathology. Over the past two decades, the use of ultrasound in the prehospital setting has become an important tool for triage, diagnosis, and treatment, especially in austere and remote environments that lack appropriate radiography capability and logistical support. The purpose of our study was to assess the accuracy of ultrasound in the austere, combat environment for diagnosis of orthopedic fracture. Methods. We conducted a longitudinal, prospective, observational study on patients presenting with suspected closed fractures using a digital handheld ultrasound device. All patients presenting with suspected fracture underwent an ultrasound examination by a board-certified emergency medicine physician credentialed in emergency ultrasonography. Patients were then categorized into ultrasound-positive and ultrasound-negative groups. Results. A total of 44 subjects underwent ultrasound examination for suspected fractures. There were initially 12 (27%) positive and 32 (73%) negative scans. Of the initial 12 positive scans, ten had a true fracture verified by plain radiography. Ultrasonography yielded an overall sensitivity of 100% and a specificity of 94%. Only four patients with an initial negative ultrasound scan continued to have clinical symptoms for more than three days and were found to have no evidence of fracture by radiograph. Conclusions. Our data show that use of ultrasound by an experienced clinician in the austere environment can be performed accurately and can possibly prevent unnecessary evacuations for suspected fractures requiring radiographic verification. The purpose of our study was to assess the accuracy of ultrasound examination in the austere, combat environment for diagnosis of orthopedic fracture. C1 [McNeil, Christopher R.; McManus, John; Mehta, Sumeru] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA. RP McNeil, C (reprint author), BAMC, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 14 TC 20 Z9 21 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PY 2009 VL 13 IS 1 BP 50 EP 52 AR PII 907832902 DI 10.1080/10903120802474513 PG 3 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 394UQ UT WOS:000262476500008 PM 19145524 ER PT J AU Black, IH McManus, J AF Black, Ian H. McManus, John TI Pain Management in Current Combat Operations SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE pain; pain management; battlefield; combat ID TRANSMUCOSAL FENTANYL CITRATE; CYCLOOXYGENASE-2 INHIBITORS; POSTOPERATIVE PAIN; CASUALTY CARE; NERVE BLOCK; KETAMINE; GABAPENTIN; ANALGESIA; ENVIRONMENT; VOLUNTEERS AB Pain management in the U.S. Military, particularly in combat, shares many of the same principles found in civilian heath care organizations and institutions. Pain is one of the most common reasons for which soldiers seek medical attention in the combat environment, which mirrors the civilian experience. However, the combat environment exacerbates the typical challenges found in treating acute pain and has the additional obstacles of a lack of supplies and equipment, delayed or prolonged evacuation times and distances, devastating injuries, provider inexperience, and dangerous tactical situations. These factors contribute to the difficulty in controlling a soldier's pain in combat. Furthermore, civilian health care providers have also learned the importance of practicing pain management principles in austere and tactical environments because of recent natural and man-made domestic disasters. Pain management research, education, and treatment strategies have been created to try to achieve adequate battlefield analgesia, and these lessons learned may aid civilian health care providers if the circumstances arise. This article presents a brief history and current overview of pain management for combat casualties on today's battlefield. Recent natural disasters and increased threats for terrorist acts have proven the need for civilian health care providers to be properly trained in pain management principles in an austere or tactical environment. C1 [Black, Ian H.; McManus, John] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP McManus, J (reprint author), Brooke Army Med Ctr, Dept Emergency Med, Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 40 TC 17 Z9 18 U1 0 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PY 2009 VL 13 IS 2 BP 223 EP 227 AR PII 909567478 DI 10.1080/10903120802290778 PG 5 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 419MT UT WOS:000264224400012 PM 19291561 ER PT J AU Chen, LY Reisner, AT Gribok, A Reifman, J AF Chen, Liangyou Reisner, Andrew T. Gribok, Andrei Reifman, Jaques TI Exploration of Prehospital Vital Sign Trends for the Prediction of Trauma Outcomes SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE vital signs; trauma; hemorrhage; trends; variability ID INTENSIVE-CARE-UNIT; BLOOD-PRESSURE; LIFESAVING INTERVENTIONS; HYPOTENSION; MORTALITY; TRIAGE; SCORE; HYPOVOLEMIA; HELICOPTERS; TRANSPORT AB Objectives. We explored whether there are diagnostically useful temporal trends in prehospital vital signs of trauma patients. Methods. Vital signs were monitored during transport to a level I trauma center and electronically archived. Retrospectively, we identified reliable vital signs recorded from the 0- to 7-minute interval and from the 14- to 21-minute interval during transport, and, for each subject, we computed the temporal differences between the two intervals' vital signs, the intrasubject 95% data ranges, the values during the initial 2 minutes, and the 21-minute overall means. We tested for differences between subjects with major hemorrhage versus control subjects, and computed receiver-operating characteristic (ROC) curves. We conducted sensitivity analyses, exploring alternative clinical outcomes, temporal windows, and methods of identifying reliable data. Results. Comparing major hemorrhage cases versus controls, there were no discriminatory differences in temporal vital sign trends. Hemorrhage cases had significantly wider intrasubject data ranges for systolic blood pressure (SBP), respiratory rate (RR), and shock index (SI) versus controls. All results were consistent in several sensitivity analyses. Conclusions. Our findings add to a growing body of evidence that prehospital vital sign trends over 21 minutes or less are unlikely to be diagnostically useful because of substantial nondirectional fluctuations in vital signs that would obscure any subtle, progressive temporal trends. SBP, RR, and SI values were significantly different for high-acuity patients, and had more variability. Taken together, these findings suggest that higher-acuity patients experience episodes of instability rather than gradual, steady decline. Measures that account for data variability, such as taking the average of multiple measurements, may improve the diagnostic utility of prehospital vital signs. C1 [Chen, Liangyou; Reisner, Andrew T.; Gribok, Andrei; Reifman, Jaques] USA, Med Res & Mat Command, TATRC, Ft Detrick, MD USA. [Reisner, Andrew T.] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, TATRC, ATTN MCMR TT Bldg 363 Miller Dr, Ft Detrick, MD USA. EM reifman@us.army.mil FU Combat Casualty Care Research Area Directorate of the U. S. Army Medical Research and Materiel Command, Fort Detrick, Maryland FX Supported by the Combat Casualty Care Research Area Directorate of the U. S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. The authors have no conflicts of interest to disclose. NR 32 TC 27 Z9 28 U1 0 U2 4 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PY 2009 VL 13 IS 3 BP 286 EP 294 AR PII 912029366 DI 10.1080/10903120902935298 PG 9 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 454AQ UT WOS:000266654400003 PM 19499463 ER PT J AU Gerhardt, RT Matthews, JM Sullivan, SG AF Gerhardt, Robert T. Matthews, Joseph M. Sullivan, Scott G. TI The Effect of Systemic Antibiotic Prophylaxis and Wound Irrigation on Penetrating Combat Wounds in a Return-to-Duty Population SO PREHOSPITAL EMERGENCY CARE LA English DT Article CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 24-28, 2008 CL Chicago, IL SP Amer Coll Emergency Phys DE antibiotic prophylaxis; penetrating trauma; military medicine; war; wound infection; wound irrigation ID PREVENTION; MANAGEMENT; INFECTION; INJURIES AB Background. Systemic antibiotic prophylaxis (SAP) for combat wounds is controversial. Current military practice favors its use, despite scant supporting evidence. Objective. To analyze outcomes of combat casualties returned to duty after initial wound care for penetrating trauma, comparing infection rates based on whether SAP was administered and whether wounds were irrigated. Setting: Forward operating base in Central Iraq, with units engaged in urban combat. Methods. This was a retrospective cohort study using field medical records. Wound mechanism, location, antibiotic use, and clinical course were abstracted. Subjects were excluded if injuries were isolated burns or eye trauma or if follow-up was not documented. Statistical analysis: Contingency table analysis, Fisher's exact test, and odds ratios were used. Results. Fifty-eight eligible cases were identified; five were excluded for incomplete follow-up (four) or confounding injuries (one). Of the remaining 53 cases, 43 included receipt of SAP (81%). Wound mechanisms and anatomic locations were comparable between groups. Infections developed within 48 hours in 7% of the SAP cases versus 40% without SAP (no SAP); odds ratio 0.11 (95% confidence interval [CI] 0.02 to 0.57); number needed to treat (NNT) 3 (95% CI 2 to 14). Forty-four subjects received wound irrigation (83%). Infections developed within 48 hours in two (4.5%) irrigated cases versus five (55%) without irrigation (no irrigation); odds ratio 0.04 (95% CI 0.006 to 0.24); NNT 2 (95% CI 1.4 to 4.7). Further 4 x 2 contingency table analysis yielded wound infection rates as follows: no SAP/irrigation, 17%; SAP/no irrigation, 40%; SAP/irrigation, 2.6%; no SAP/no irrigation, 75% (Fisher's exact p 0.0005). Conclusions. We detected independent and combined associations among SAP, irrigation, and significantly decreased wound infection rates. Effects of SAP and irrigation may be synergistic. Copious irrigation with potable water or sterile isotonic solution should be performed at the earliest practical juncture after a wound occurs. SAP should be administered if irrigation cannot be performed, and may be warranted in addition to irrigation for complex or contaminated wounds or if expeditious return to duty is required. Larger epidemiologic studies are needed to validate our findings. C1 [Gerhardt, Robert T.; Matthews, Joseph M.] Brooke Army Med Ctr, Dept Emergency Med, San Antonio Uniformed Serv Hlth Educ Consortium, Ft Sam Houston, TX 78234 USA. [Gerhardt, Robert T.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Gerhardt, Robert T.; Sullivan, Scott G.] 12th US Cavalry Regiment, Battal 1, Cavalry Div 1, Ft Hood, TX USA. [Gerhardt, Robert T.] US Army Inst Surg Res, Prehosp Res Branch, Ft Sam Houston, TX USA. RP Gerhardt, RT (reprint author), Brooke Army Med Ctr, Dept Emergency Med, San Antonio Uniformed Serv Hlth Educ Consortium, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM robert.gerhardt@us.army.mil NR 9 TC 9 Z9 9 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PY 2009 VL 13 IS 4 BP 500 EP 504 AR PII 914289530 DI 10.1080/10903120903144841 PG 5 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 491TM UT WOS:000269602500013 PM 19731163 ER PT S AU Hainer, MI Sketch, MH AF Hainer, Mark I. Sketch, Michael H. BE Tcheng, JE TI Operator and Site Requirements for Primary Coronary Intervention SO PRIMARY ANGIOPLASTY IN ACUTE MYOCARDIAL INFARCTION, SECOND EDITION SE Contemporary Cardiology LA English DT Article; Book Chapter ID ACUTE-MYOCARDIAL-INFARCTION; NEW-YORK-STATE; PRACTICE GUIDELINES COMMITTEE; ASSOCIATION TASK-FORCE; PRIMARY ANGIOPLASTY; ON-SITE; AMERICAN-COLLEGE; THROMBOLYTIC THERAPY; ACC/AHA GUIDELINES; NATIONAL REGISTRY C1 [Sketch, Michael H.] Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27710 USA. [Hainer, Mark I.] William Beaumont Army Med Ctr, Ft Bliss, TX USA. RP Sketch, MH (reprint author), Duke Univ, Med Ctr, Div Cardiol, Durham, NC 27710 USA. EM sketc002@mc.duke.edu NR 44 TC 0 Z9 0 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1191-7601 BN 978-1-60327-497-5 J9 CONTEMP CARDIOL JI Contemp. Cardiol. PY 2009 BP 27 EP 46 DI 10.1007/978-1-60327-497-5_3 D2 10.1007/978-1-60327-497-5 PG 20 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA BNF85 UT WOS:000274463900003 ER PT B AU Maymi, FJ Rodriguez-Martinez, M AF Maymi, Fernando J. Rodriguez-Martinez, Manuel GP IEEE Computer Society TI Obstacle Avoidance for Utility-Based Geocasting SO PROCEEDINGS OF THE 2009 SIXTH INTERNATIONAL CONFERENCE ON INFORMATION TECHNOLOGY: NEW GENERATIONS, VOLS 1-3 LA English DT Proceedings Paper CT 6th International Conference on Information Technology - New Generations (ITNG 2009) CY APR 27-29, 2009 CL Las Vegas, NV SP IEEE Comp Soc AB Geocasting is the delivery of messages to all recipients within a specific geospatial region. While good algorithms exist to provide geocasting services, they do not perform well in the presence of large obstacles. We define an obstacle as any region of the network through which a message may not be directly transmitted. Given this definition, we developed a simple mechanism that allows messages to skirt around obstacles and ultimately reach their destination. We claim that this approach can dramatically improve the delivery rates of messages in adverse topologies, and support our claim with experimental results including both our utility function based geocasting protocol as well as the well-known Location Based Multicast (LBM) and Voronoi Region multicasting approaches. C1 [Maymi, Fernando J.] Univ Puerto Rico, US Army, Mayaguez, PR 00931 USA. [Rodriguez-Martinez, Manuel] Univ Puerto Rico, Dept Elect & Comp Engn, Mayaguez, PR USA. RP Maymi, FJ (reprint author), Univ Puerto Rico, US Army, Mayaguez, PR 00931 USA. EM fernando.maymi@us.army.mil; manuel.rodriguez7@upr.edu NR 8 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3770-2 PY 2009 BP 338 EP + DI 10.1109/ITNG.2009.326 PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA BLQ66 UT WOS:000270815100059 ER PT S AU Ahner, D AF Ahner, Darryl GP IEEE TI A NORMALIZED WEIGHTED ENTROPY MEASURE FOR SENSOR ALLOCATION WITHIN SIMULATIONS SO PROCEEDINGS OF THE 2009 WINTER SIMULATION CONFERENCE (WSC 2009 ), VOL 1-4 SE Winter Simulation Conference Proceedings LA English DT Proceedings Paper CT Winter Simulation Conference 2009 CY DEC 13-16, 2009 CL Austin, TX SP IEEE ID QUALITY AB Information superiority is considered a critical capability for future joint forces. Sensor allocation and information processing are critical to achieving this information superiority but the value of information is difficult to assess. We develop a weighted entropy measure for sensor allocation within simulations by using the Dynamic Model of Situated Cognition as a framework in which to view the processing and flow of information in a complex technological-cognitive system. The entropy measure developed is normalized across each requirement and weighted according to the Commander's priorities within the phase of that operation. We develop a methodology for implementation for this normalized weighted entropy measure to allocate sensors within a combat simulation. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Ahner, D (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM darryl.ahner@us.army.mil NR 22 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0891-7736 BN 978-1-4244-5770-0 J9 WINT SIMUL C PROC PY 2009 BP 1712 EP 1722 PG 11 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Operations Research & Management Science SC Computer Science; Engineering; Operations Research & Management Science GA BUJ11 UT WOS:000289492501023 ER PT B AU Pelaez, JC AF Pelaez, Juan C. BE Tjoa, AM Wagner, RR TI Using Misuse Patterns for VoIP Steganalysis SO PROCEEDINGS OF THE 20TH INTERNATIONAL WORKSHOP ON DATABASE AND EXPERT SYSTEMS APPLICATION LA English DT Proceedings Paper CT 20th International Conference on Database and Expert Systems Applications CY AUG 31-SEP 04, 2009 CL Linz, AUSTRIA SP DEXA Assoc, Austrian Comp Soc, Res Inst Appl Knowledge Proc, Johannes Kepler Univ Linz AB The growing interest in Voice over Internet Protocol (VoIP) communications increased the fear that criminal and terrorist groups are switching to this technology to coordinate their operations. VoIP services that cannot be monitored and lawfully intercepted may be used to perform illegal activity. Converged networks are vulnerable to steganographic attacks due to their high bandwidth usage. This feature provides a way to embed hidden messages in either the VoIP signaling or media streams making steganalysis harder to accomplish. This paper discusses a systematic approach to analyze steganography in VoIP using misuse patterns [PeI09]. Misuse patterns describe, from the point of view of the attacker, how a type of information misuse is performed, analyzes the ways of stopping the attack, and considers how to trace the attack once it has happened. The pattern also attempts to correlate events with specific parts of the system. We will use these semiformal models as a method to improve the detection of embedded hidden messages in IP telephony. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pelaez, JC (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM juan.c.pelaez@arl.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA BN 978-0-7695-3763-4 PY 2009 BP 160 EP 164 DI 10.1109/DEXA.2009.90 PG 5 WC Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BNV26 UT WOS:000275655300031 ER PT J AU Anderson, WR Conner, CB AF Anderson, William R. Conner, Clint B. TI Comparison of gas-phase mechanisms applied to RDX combustiori model SO PROCEEDINGS OF THE COMBUSTION INSTITUTE LA English DT Article DE Solid propellants; Burning rates; Kinetics mechanisms; Modeling ID FLAME STRUCTURE; DECOMPOSITION; PROPELLANTS AB Two detailed gas-phase chemical mechanisms for RDX - Yetter and coworkers, herein 'Y2' [K. Prasad. R.A. Yetter, M.D. Smooke, Combust. Sci. Technol. 124 (1997) p. 35.] Cal. Tech. group, herein 'CTM' [(a) A.D. Chakraborty, R.P. Muller, S. Dasgupta, W.A. Goddard, III, J. Phys. Chem. A 104 (2000) 2261. (b) D. Chakraborty, R.P. Muller, S. Dasgupta, W.A. Goddard. III, J. Comput. Aided Mater. Des. 8 (2001) 203. (c) D. Chakraborty, R.P. Muller. S. Dasgupta. W.A. Goddard, III, Available from: http://www.wag.caltech.edu/home/rpm/projects/hedm/] - have been tested using a recently developed combustion model. The results are compared with each other and experimental data. Burning rates predicted using CTM are about 15%, higher than Y2, but both compare well with experimental data across a wide pressure range. Also. majority species profiles tire in reasonable agreement with data from a 0.5 atm pressure experiment. However, comparison of predicted trace species profiles to experiments indicates neither mechanism reproduces all measured trace species well: furthermore, most of these trace species Occur along main reaction pathways. Detailed chemical analysis indicates the main initial RDX reaction is surprisingly very different for the two mechanisms. NO(2) scission dominates using Y2, but HONO elimination dominates using CTM in spite of the NO(2) scission reaction having by far the largest RDX decomposition rate coefficient in each mechanism. Analysis shows the unexpected result using CTM is due to a Curious global kinetics phenomenon arising in the product pathway: the ring-opening reaction, RDXR -> RDXRO, where RDXR is the cyclic radical formed upon NO(2) scission, has a much smaller rate coefficient in CTM compared to Y2. This causes the reaction to be a bottleneck, and so the NO(2) scission reaction goes into partial equilibrium rather than being forwards. Tests were performed to see how the predicted burning rates would be affected by changes in some of the most sensitive rate parameters. Some of the key parameters leading to the differing predictions have been identified. These results will help guide future efforts to understand and develop an accurate representation of the actual RDX combustion chemistry. (C) 2009 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 [Anderson, William R.; Conner, Clint B.] USA, Res Lab, Prop Sci Branch, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. RP Anderson, WR (reprint author), USA, Res Lab, Prop Sci Branch, AMSRD ARL WM BD, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM willie@arl.army.mil; conner.c@maplan.com FU Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory; ARL Major Shared Resource Center (MSRC) [ARLAP02642500] FX C.B.C. was supported by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. We are grateful to Dr. Chiung-Chu Chen and Prof. Joseph W. Bozzelli for enlightening discussions. We thank the ARL Major Shared Resource Center (MSRC) for computer time under project #ARLAP02642500. NR 20 TC 12 Z9 12 U1 2 U2 12 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1540-7489 J9 P COMBUST INST JI Proc. Combust. Inst. PY 2009 VL 32 BP 2123 EP 2130 DI 10.1016/j.proci.2008.05.023 PG 8 WC Thermodynamics; Energy & Fuels; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 427CH UT WOS:000264756900059 ER PT J AU Conner, CB Anderson, WR AF Conner, Clint B. Anderson, William R. TI Modeling the combustion of JA2 and solid propellants of similar composition SO PROCEEDINGS OF THE COMBUSTION INSTITUTE LA English DT Article DE Solid propellants; Burning rates; Modeling AB A theoretical study on combustion of JA2, RPD-380, and RPD-351, which are modified double-base propellants composed primarily of three identical nitrate ester ingredients, is presented. A one-dimensional, two-phase model was used [M.S. Miller, W.R. Anderson, in: V. Yang, T.B. Brill, W.Z. Ren (Eds.), Solid Propellant Combustion Chemistry, Combustion and Motor Interior Ballistics, Progress in Astronautics and Aeronautics, vol. 185. AIAA, Reston, VA, 2000 pp. 501-531, (a) M.S. Miller, W.R. Anderson, J. Propul Power 20(3) (2004) 440-454. (b) M.S. Miller, W.R. Anderson, CYCLOPS, A Breakthrough Code to Predict Solid-Propellant Burning Rates, U.S. Army Research Laboratory Technical Report, 1987 ARL-TR-2910.]. This approach has been shown to give good agreement between predicted and experimental results for several nitrate ester propellants, including JA2 [(a) M.S. Miller, W.R. Anderson, J. Propul. Power 20 (3) (2004) 440-454. (b) M.S. Miller, W.R. Anderson, CYCLOPS, A Breakthrough Code to Predict Solid-Propellant Burning Rates, U.S. Army Research Laboratory Technical Report, 1987 ARL-TR-2910.]. Extension of the model to the two RPD variants yields results in good agreement with existing experimental data. Comparisons of the response of predicted burning rates to experimental formulation changes at gun pressures, and to the initial propellant temperature are particularly encouraging. Our results show the burning rate ordering of these propellants is JA2 < RPD-380 < RPD-351 at all pressures. Chemistry which appears to account for this ordering is discussed. Also, an upgraded mechanism Was used, and the reasons for some slight changes in results vs. an older one are identified. Sensitivities of the computed temperatures near the propellant surface to the various reactions' rate coefficients are discussed; these provide insights regarding which reactions are centrally important to the computed burning rates and solutions. The spatial structure of one propellant flame - temperature and species profiles - is given; variations vs. the formulations and pressure are discussed. The fidelity of burning rate response to mixture ratio and initial propellant temperature are encouraging that the model may find application in propellant formulation science and elsewhere. (C) 2009 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 [Conner, Clint B.; Anderson, William R.] USA, Res Lab, Prop Sci Branch, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. RP Anderson, WR (reprint author), USA, Res Lab, Prop Sci Branch, AMSRD ARL WM BD, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM conner.c@maplan.com; willie@arl.army.mil FU Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory; ARL Major Shared Resource Center (MSRC) [ARLAP02642500] FX CBC was supported by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. We thank the ARL Major Shared Resource Center (MSRC) for allowing use of their computer time under project #ARLAP02642500. NR 14 TC 1 Z9 1 U1 2 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1540-7489 J9 P COMBUST INST JI Proc. Combust. Inst. PY 2009 VL 32 BP 2131 EP 2137 DI 10.1016/j.proci.2008.06.059 PG 7 WC Thermodynamics; Energy & Fuels; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 427CH UT WOS:000264756900060 ER PT J AU Federici, JA Wetzel, ED Geil, BR Vlachos, DG AF Federici, J. A. Wetzel, E. D. Geil, B. R. Vlachos, D. G. TI Single channel and heat recirculation catalytic microburners: An experimental and computational fluid dynamics study SO PROCEEDINGS OF THE COMBUSTION INSTITUTE LA English DT Article DE Propane; Catalytic microcombustion; Stability; Heat recirculation; Optimal catalyst placement ID PROPANE/AIR MICROFLAME STABILITY; COMBUSTION; MICROREACTORS; GENERATION; MIXTURES; SYSTEMS; REACTOR; BURNER; CFD AB The stability of C(3)H(8)/air mixtures on Pt in single channel and heat recirculation catalytic microburners is compared experimentally using a microreactor capable of operating in both modes. The stability is further studied using Computational fluid dynamics Simulations, where the material properties of the burner can be systematically changed. It is shown through both experiments and simulation that catalytic heat recirculation burners have similar stability to single channel burners in the limit of highly conductive walls. In contrast, for low conductivity walls, heat recirculation proves to be effective at increasing combustion stability relative to single channel burners. Increasing the flow rate significantly extends the fuel lean extinction limit at low inlet velocities. Finally, optimal catalyst placement in heat recirculating burners is discussed. (C) 2009 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 [Federici, J. A.; Vlachos, D. G.] Univ Delaware, Ctr Catalyt Sci & Technol CCST, Dept Chem Engn, Newark, DE 19716 USA. [Federici, J. A.; Vlachos, D. G.] Univ Delaware, Ctr Composite Mat CCM, Colburn Lab 353, Newark, DE 19716 USA. [Wetzel, E. D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Geil, B. R.] USA, Res Lab, Adelphi, MD 20783 USA. RP Vlachos, DG (reprint author), Univ Delaware, Ctr Catalyt Sci & Technol CCST, Dept Chem Engn, Colburn Lab 353,150 Acad St, Newark, DE 19716 USA. EM federici@udel.edu; vlachos@udel.edu OI Vlachos, Dionisios/0000-0002-6795-8403 FU Army Research Laboratory [W911NF-06-2-0011] FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-0011. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government IS authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation heron. J.A.F. would also like to thank Dr. Ayman Karim for his assistance with the TEM. NR 22 TC 24 Z9 26 U1 3 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1540-7489 J9 P COMBUST INST JI Proc. Combust. Inst. PY 2009 VL 32 BP 3011 EP 3018 DI 10.1016/j.proci.2008.07.005 PG 8 WC Thermodynamics; Energy & Fuels; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 427CH UT WOS:000264756900164 ER PT B AU Corron, NJ Reed, BR Blakely, JN Myneni, K Pethel, SD AF Corron, Ned J. Reed, Billy R. Blakely, Jonathan N. Myneni, Krishna Pethel, Shawn D. GP IEEE TI Chaotic Scrambling for Wireless Analog Video SO PROCEEDINGS OF THE IEEE SOUTHEASTCON 2009, TECHNICAL PROCEEDINGS LA English DT Proceedings Paper CT IEEE SoutheastCon 2009 CY MAR 05-08, 2009 CL Atlanta, GA SP IEEE Reg 3, IEEE Atlanta Sect, Georgia Tech IEEE Student Branch ID SYNCHRONIZATION AB We report the implementation of a novel in-band chaotic scrambler for securing wireless analog video. In this demonstration system, an analog video signal is injected into a chaotic oscillator and the output is transmitted through a standard wireless radio link. At the receiver, a descrambler separates the video from the chaotic signal in real time. Experimental results show the scrambled signal effectively hides the original video image, yet the descrambler recovers the original color video with reasonable clarity and detail. Compared to digital encryption, chaotic scrambling offers an efficient, low-cost alternative for masking time-critical analog communications. C1 [Corron, Ned J.; Blakely, Jonathan N.; Myneni, Krishna; Pethel, Shawn D.] US Army, RDECOM, Washington, DC USA. [Reed, Billy R.] Sci Applicat Int Corp, Mclean, VA USA. RP Corron, NJ (reprint author), US Army, RDECOM, Washington, DC USA. EM ned.corron@us.army.mil; billy.r.reed@saic.com; jonathan.blakely@us.army.mil; krishna.myneni@us.army.mil; shawn.pethel@us.army.mil OI Corron, Ned/0000-0002-3232-5024; Blakely, Jonathan/0000-0002-9772-582X NR 9 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3977-5 PY 2009 BP 38 EP + PG 2 WC Engineering, Multidisciplinary SC Engineering GA BMM93 UT WOS:000272863900008 ER PT B AU Cetin, B Bikdash, M McInerney, M AF Cetin, B. Bikdash, M. McInerney, M. GP IEEE TI Automated Electric Utility Pole Detection from Aerial Images SO PROCEEDINGS OF THE IEEE SOUTHEASTCON 2009, TECHNICAL PROCEEDINGS LA English DT Proceedings Paper CT IEEE SoutheastCon 2009 CY MAR 05-08, 2009 CL Atlanta, GA SP IEEE Reg 3, IEEE Atlanta Sect, Georgia Tech IEEE Student Branch AB This paper presents an algorithm for the recognition of similar electrical poles from an aerial image by detecting the pole shadow. One pole is used as a template (already identified by a human operator) for the algorithm. The algorithm includes feature extraction, candidate position determination, and elimination of redundant candidates. First, features of a pole shadow are extracted using standard filters and image processing techniques. Then the extracted features are used to design convolution filters tailored to emphasize possible locations for the shadows. Subsequently, an image candidate is submitted to Radon Transformation to verify adherence to expected shadow characteristics. Simulations show that most poles are made much more noticeable by the algorithm. C1 [Cetin, B.; Bikdash, M.] NC A&T State Univ, Greensboro, NC 27411 USA. [McInerney, M.] US Army, CERL, Mississippi State, MS USA. RP Cetin, B (reprint author), NC A&T State Univ, Greensboro, NC 27411 USA. EM bcetin@ncat.edu; bikdash@ncat.edu; Michael.K.McInerney@erdc.usace.army.mil FU Army Construction Engineering Research Laboratory (CERL) [W1932T-06-P-0093] FX This work has been supported by the Army Construction Engineering Research Laboratory (CERL) under contracts W1932T-06-P-0093. We appreciate their support. NR 12 TC 2 Z9 2 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3977-5 PY 2009 BP 44 EP + PG 2 WC Engineering, Multidisciplinary SC Engineering GA BMM93 UT WOS:000272863900009 ER PT S AU Sano, T Chin, ESC Paliwal, E Chen, MW AF Sano, T. Chin, E. S. C. Paliwal, E. Chen, M. W. BE Bansal, NP Singh, JP TI COMPARISON OF SLIP CAST TO HOT PRESSED BORON CARBIDE SO PROCESSING AND PROPERTIES OF ADVANCED CERAMICS AND COMPOSITES SE Ceramic Transactions LA English DT Proceedings Paper CT Materials Science and Technology Conference and Exhibition (MS&T 08) CY OCT 05-09, 2008 CL Pittsburgh, PA ID CERAMICS AB To meet the possible increase in future demand for armor materials, an increase in the throughput during manufacturing is necessary One possibility is the use of the slip casting and sintering technique to form ceramic armor compacts as an alternative to current hot pressing techniques Dynamic uniaxial compression tests with the Kolsky bar were conducted on two types of slip cast boron carbide, and compared with results from the standard hot pressed boron carbide One type was slip cast, sintered, and hot isostatically pressed, while the other was only slip cast and sintered Microstructural characterization by transmission electron microscopy showed graphite inclusions and more annealing twins than in the hot pressed boron carbide material Examination of fragments recovered from the compression tests determined that the fracture mode of both slip cast materials was brittle transgranular cleavage The compression test results show comparable compressive strengths between the sip cast and hot pressed boron carbide despite higher density of graphite in the slip cast material C1 [Sano, T.; Chin, E. S. C.] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Paliwal, E.] Johns Hopkins Univ, Dept MEch Engn, Baltimore, MD USA. [Chen, M. W.] Johns Hopkins Univ, Inst Mat Res, Baltimore, MD USA. RP Sano, T (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. NR 8 TC 2 Z9 2 U1 0 U2 6 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 1042-1122 BN 978-0-470-40845-2 J9 CERAM TRANS PY 2009 VL 203 BP 107 EP + DI 10.1002/9780470522189.ch10 PG 2 WC Materials Science, Ceramics; Materials Science, Composites SC Materials Science GA BSU33 UT WOS:000285825100010 ER PT S AU West, BJ AF West, Bruce J. BE Sternad, D TI Control from an Allometric Perspective SO PROGRESS IN MOTOR CONTROL: A MULTIDISCIPLINARY PERSPECTIVE SE Advances in Experimental Medicine and Biology LA English DT Article; Proceedings Paper CT 5th Conference on Progress in Motor Control - A Multidisciplinary Perspective CY AUG 19-22, 2005 CL Penn State Univ, University Pk, PA HO Penn State Univ ID HUMAN GAIT; FRACTIONAL CALCULUS; HEARTBEAT; DYNAMICS; WALKING AB Control of complexity is one of the goals of medicine, in particular, understanding and controlling physiological networks in order to ensure their proper operation. I have attempted to emphasize the difference between homeostatic control and allometric control mechanisms. Homeostatic control is familiar and has as its basis a negative feedback character, which is both local and relatively fast. Allometric control, on the other hand, is a new concept that can take into account long-time memory, correlations that are inverse power law in time, as well as long-range interactions in complex phenomena as manifest by inverse power-law distributions in the system variable. Allometric control introduces the fractal character into otherwise featureless random time series to enhance the robustness of physiological networks by introducing the fractional calculus into the control of the networks. C1 USA, Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP West, BJ (reprint author), USA, Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. EM Bruce.J.West@us.army.mil NR 32 TC 6 Z9 6 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0065-2598 BN 978-0-387-77063-5 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2009 VL 629 BP 57 EP 82 DI 10.1007/978-0-387-77064-2_4 PG 26 WC Medicine, Research & Experimental; Neurosciences SC Research & Experimental Medicine; Neurosciences & Neurology GA BIT63 UT WOS:000262627200004 PM 19227495 ER PT J AU Kocifaj, M Videen, G AF Kocifaj, Miroslav Videen, Gorden TI Antenna design via inverse beamforming SO PRZEGLAD ELEKTROTECHNICZNY LA English DT Article DE beamforming; antenna design; electromagnetic radiation; dipoles ID STEERED ARRAY-ANTENNA AB The electromagnetic power generated by a linear phased-array system of radiating dipoles is analyzed theoretically. We introduce the concept of forced phase shift for any pair of dipoles, thus enabling wide-range adaptability of the antenna beam pattern. The exact solution of the electromagnetic power results in a set of formulae that can be used to solve the inverse problem of determining the optimum configuration of the phase shifts. Such a configuration guarantees that a modeled distribution of the radiating powers coincides with the predefined requirements as well as possible. Discretization of the continuous model is adopted so the optimum solution can be found for selected zones in the vicinity of the source of radiation C1 [Kocifaj, Miroslav] Slovak Acad Sci, ICA, Bratislava 84503, Slovakia. [Videen, Gorden] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Kocifaj, M (reprint author), Slovak Acad Sci, ICA, Dubravska Cesta 9, Bratislava 84503, Slovakia. EM kocifaj@savba.sk; gvideen@arl.army.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU WYDAWNICTWO SIGMA - N O T PI WARSAW PA UL RATUSZOWA 11,, 00-950 WARSAW, POLAND SN 0033-2097 J9 PRZ ELEKTROTECHNICZN JI Prz. Elektrotechniczny PY 2009 VL 85 IS 7 BP 49 EP 53 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA 466AX UT WOS:000267633700010 ER PT J AU Brunye, TT Ditman, T Mahoney, CR Augustyn, JS Taylor, HA AF Brunye, Tad T. Ditman, Tali Mahoney, Caroline R. Augustyn, Jason S. Taylor, Holly A. TI When You and I Share Perspectives Pronouns Modulate Perspective Taking During Narrative Comprehension SO PSYCHOLOGICAL SCIENCE LA English DT Article ID LANGUAGE COMPREHENSION; SITUATION MODELS; MEMORY; ACCESSIBILITY; INFORMATION AB Readers mentally simulate the objects and events described in narratives. One common assumption is that readers mentally embody an actor's perspective; alternatively, readers might mentally simulate events from an external "onlooker" perspective. Two experiments examined the role of pronouns in modulating a reader's adopted perspective when comprehending simple event sentences. Experiment 1 demonstrated that readers embody an actor's perspective when the pronoun you or I is used, but take an external perspective when he is used. Experiment 2, however, found that a short discourse context preceding the event sentence led readers to adopt an external perspective with the pronoun I. These experiments demonstrate that pronoun variation and discourse context mediate the degree of embodiment experienced during narrative comprehension: In all cases, readers mentally simulate objects and events, but they embody an actor's perspective only when directly addressed as the subject of a sentence. C1 [Brunye, Tad T.; Mahoney, Caroline R.; Augustyn, Jason S.] USA, NSRDEC, Attn AMSRD NSC WS P, Natick, MA 01760 USA. [Brunye, Tad T.; Ditman, Tali; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Medford, MA 02155 USA. [Ditman, Tali] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Cambridge, MA 02138 USA. RP Brunye, TT (reprint author), USA, NSRDEC, Attn AMSRD NSC WS P, 15 Kansas St, Natick, MA 01760 USA. EM tbrunye@alumni.tufts.edu RI 江, 鈺麒/G-1379-2014 NR 22 TC 66 Z9 66 U1 2 U2 16 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0956-7976 J9 PSYCHOL SCI JI Psychol. Sci. PD JAN PY 2009 VL 20 IS 1 BP 27 EP 32 DI 10.1111/j.1467-9280.2008.02249.x PG 6 WC Psychology, Multidisciplinary SC Psychology GA 392EH UT WOS:000262285200006 PM 19076318 ER PT S AU Brandt, HE AF Brandt, Howard E. BE Donkor, EJ Pirich, AR Brandt, HE TI Riemann Curvature in Quantum Computational Geometry SO QUANTUM INFORMATION AND COMPUTATION VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Quantum Information and Computation VII CY APR 16-17, 2009 CL Orlando, FL SP SPIE DE quantum computing; quantum circuits; quantum complexity; differential geometry; Riemannian geometry; curvature; geodesics AB In the Riemannian geometry of quantum computation, the quantum evolution is described in terms of the special unitary group SU(2(n)) of n-qubit unitary operators with unit determinant. To elaborate on one aspect of the methodology, the Riemann curvature and sectional curvature are explicitly derived using the Lie algebra su(2(n)). This is important for investigations of the global characteristics of geodesic paths in the group manifold. C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM hbrandt@arl.army.mil NR 22 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7608-1 J9 PROC SPIE PY 2009 VL 7342 AR 734208 DI 10.1117/12.820876 PG 11 WC Computer Science, Hardware & Architecture; Optics SC Computer Science; Optics GA BCS48 UT WOS:000311280400006 ER PT S AU Brandt, HE AF Brandt, Howard E. BE Donkor, EJ Pirich, AR Brandt, HE TI Aspects of Quantum Computational Geodesics SO QUANTUM INFORMATION AND COMPUTATION VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Quantum Information and Computation VII CY APR 16-17, 2009 CL Orlando, FL SP SPIE DE quantum computing; quantum circuits; quantum complexity; Riemannian geometry; quantum computational geodesics AB The object of this paper is to mathematically investigate characteristics of a geodesic equation describing possible minimum complexity paths in the special unitary group manifold representing the unitary evolution of n qubits associated with a quantum computation. Simple solutions are elaborated for the case of three qubits. C1 USA, Res Lab, Adelphi, MD USA. RP Brandt, HE (reprint author), USA, Res Lab, Adelphi, MD USA. EM hbrandt@arl.army.mil NR 26 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7608-1 J9 PROC SPIE PY 2009 VL 7342 AR 734205 DI 10.1117/12.817331 PG 11 WC Computer Science, Hardware & Architecture; Optics SC Computer Science; Optics GA BCS48 UT WOS:000311280400004 ER PT J AU Floersheim, RB Hou, G Firestone, K AF Floersheim, R. Bruce Hou, Gene Firestone, Kent TI CFPC material characteristics and SLS prototyping process SO RAPID PROTOTYPING JOURNAL LA English DT Article DE Polyamides; Composite materials; Sintering; Physical properties of materials; Mechanical behaviour of materials ID MECHANICAL-PROPERTIES AB Purpose - The purpose of this paper is to characterize the material properties of carbon fiber polyamide composite (CFPC) used in a 3D rapid prototyping process based upon selective laser sintering (SLS) and demonstrate that the SLS process introduces a bias in the micro-fiber orientation such that the CFPC solid is an orthotropic structural material. Design/methodology/approach - Material coupons for tensile tests from each of the orthogonal planes are created using the SLS process. After tensile testing, the coupons are examined under scanning electron microscopy to verify the micro-fiber orientation bias. A complex 3D structure developed utilizing the CFPC material is subjected to modal testing to extract the natural frequencies. These frequencies are compared to predictive numerical analysis results from computer-aided engineering (CAE) software to validate the coupon test results. Findings - This paper proves that the CFPC solid material is orthotropic after the SLS process and that the process itself creates bias in the micro-fiber orientation. Predictions of natural frequencies from CAE software for a complex 3D structure created from CFPC are within 2 percent of the actual natural frequencies determined during modal testing. Practical implications - The paper has determined the tensile material characteristics of solid CFPC correcting the original material data sheet information which lists the solid CFPC as isotropic with much stronger tensile characteristics. It has also provided evidence of the bias that SLS introduces to embedded micro-fibers during the rapid-prototyping process. Originality/value - The paper deals with experimental work on determining the material characteristics of a relatively new composite material for which very little test data exists in literature. In particular, an original contribution is demonstration of the micro-fiber orientation bias introduced by the SLS process. C1 [Floersheim, R. Bruce] US Mil Acad, W Chester, PA USA. [Hou, Gene] Old Dominion Univ, Coll Engn & Technol, Norfolk, VA USA. [Firestone, Kent] Solid Concepts Inc, Austin, TX USA. RP Floersheim, RB (reprint author), US Mil Acad, W Chester, PA USA. EM bruce.floersheim@us.army.mil NR 14 TC 2 Z9 2 U1 0 U2 19 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND SN 1355-2546 J9 RAPID PROTOTYPING J JI Rapid Prototyping J. PY 2009 VL 15 IS 5 BP 339 EP 345 DI 10.1108/13552540910993860 PG 7 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 515NU UT WOS:000271479800005 ER PT S AU Readinger, ED Metcalfe, GD Shen, PH Wraback, M Jha, N Woodward, N Capek, P Dierolf, V AF Readinger, Eric D. Metcalfe, Grace D. Shen, Paul Hongen Wraback, Michael Jha, Naveen Woodward, Nathaniel Capek, Pavel Dierolf, Volkmar BE Dierolf, V Fujiwara, Y Hommerich, U Ruterana, P Zavada, JM TI GaN Doped With Neodymium by Plasma-Assisted Molecular Beam Epitaxy for Potential Lasing Applications SO RARE-EARTH DOPING OF ADVANCED MATERIALS FOR PHOTONIC APPLICATIONS SE Materials Research Society Symposium Proceedings LA English DT Proceedings Paper CT Symposium on Rare-Earth Doping of Advanced Materials for Photonic Applications held at the 2008 MRS Fall Meeting CY DEC 01-04, 2008 CL Boston, MA SP Mat Res Soc ID INFRARED ELECTROLUMINESCENCE; ROOM-TEMPERATURE; THIN-FILMS; PHOTOLUMINESCENCE; LUMINESCENCE; SPECTROSCOPY; ER AB We provide an investigation of in situ doping of GaN with the RE element Nd by plasma assisted-molecular beam epitaxy (PA-MBE). GaN epilayers are grown on c-plane sapphire and free standing GaN substrates and the Nd doping is controlled by an effusion cell. The ideal growth conditions for Nd incorporation maintaining crystal quality in GaN were investigated. The optical absorption characteristics indicate that the GaN:Nd epilayer remains transparent at the Nd emission wavelength of interest. For the highest Nd effusion cell temperatures, Rutherford backscattering and secondary ion mass spectrometry data indicate similar to 5 at. % in epilayers grown on c-plane sapphire. X-ray diffraction found no evidence of phase segregation up to similar to 1 at. % Nd. The highest luminescence intensities correspond to a doping range 0.05-1 at. %, with the strongest emission occurring at 1.12 eV (1107 nm). We also present the Stark energy sublevels of Nd(3+) ions in GaN as determined by luminescence spectra. Photoluminescence excitation spectra reveal an optimal excitation energy of 1.48 eV (836 nm). We correlate the photoluminescence spectra with transitions from the (4)F(3/2) excited state to the (4)I(9/2), (4)I(11/2), and (4)I(13/2) multiplets of the Nd(3+) ion for above (325nm) and below (836nm) bandgap excitation. Spectral correlation of the Nd emission multiplets in addition to site-selective spectroscopy studies using combined excitation-emission spectroscopy with confocal microscopy indicate enhanced substantial doping at the Ga site compared to other techniques (ion implantation and co-sputtering). C1 [Readinger, Eric D.; Metcalfe, Grace D.; Shen, Paul Hongen; Wraback, Michael] USA, Res Lab, Adelphi, MD 20783 USA. RP Readinger, ED (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DRIVE, WARRENDALE, PA 15088-7563 USA SN 0272-9172 BN 978-1-60511-083-7 J9 MATER RES SOC SYMP P PY 2009 VL 1111 BP 17 EP 26 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA BMC23 UT WOS:000271829800003 ER PT S AU Ballal, P Lewis, FL Hudas, GR AF Ballal, P. Lewis, F. L. Hudas, G. R. BE Kyamakya, K Halang, WA Unger, H Chedjou, JC Rulkov, NF Li, Z TI Trust-Based Collaborative Control for Teams in Communication Networks SO RECENT ADVANCES IN NONLINEAR DYNAMICS AND SYNCHRONIZATION: THEORY AND APPLICATIONS SE Studies in Computational Intelligence LA English DT Article; Book Chapter ID AGENTS C1 [Hudas, G. R.] USA, RDECOM TARDEC AMSRD TAR R, Warren, MI 48397 USA. NR 20 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1860-949X BN 978-3-642-04226-3 J9 STUD COMPUT INTELL PY 2009 VL 254 BP 347 EP 363 D2 10.1007/978-3-642-04227-0 PG 17 WC Automation & Control Systems; Computer Science, Artificial Intelligence; Physics, Mathematical SC Automation & Control Systems; Computer Science; Physics GA BLP57 UT WOS:000270731500011 ER PT J AU Cohen, SP Dragovich, A Hurley, R Bajwa, ZH AF Cohen, Steven P. Dragovich, Anthony Hurley, Robert Bajwa, Zahid H. TI Diagnosis of Facet joint Pain and Prediction of Success and Failure for Cervical Facet Radiofrequency Denervation Reply SO REGIONAL ANESTHESIA AND PAIN MEDICINE LA English DT Letter ID MEDIAL BRANCH BLOCKS; MULTICENTER ANALYSIS; COST-EFFECTIVENESS; INJECTIONS C1 [Cohen, Steven P.; Hurley, Robert] Johns Hopkins Sch Med, Baltimore, MD USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Baltimore, MD USA. [Dragovich, Anthony] Womack Army Med Ctr, Ft Bragg, NC USA. [Bajwa, Zahid H.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Cambridge, MA 02138 USA. RP Cohen, SP (reprint author), Johns Hopkins Sch Med, Baltimore, MD USA. NR 15 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1098-7339 J9 REGION ANESTH PAIN M JI Region. Anesth. Pain Med. PD JAN-FEB PY 2009 VL 34 IS 1 BP 82 EP 83 PG 2 WC Anesthesiology SC Anesthesiology GA 399VW UT WOS:000262828400031 ER PT B AU Brown, SI AF Brown, Stephen I. BE Sriraman, B Goodchild, S TI HUMOR IN E(A)RNEST SO RELATIVELY AND PHILOSOPHICALLY EARNEST: FESTSCHRIFT IN HONOR OF PAUL ERNEST'S 65TH BIRTHDAY SE Montana Mathematics Enthusiast Monograph Series in Mathematics Education LA English DT Article; Book Chapter C1 USA, Washington, DC 20310 USA. RP Brown, SI (reprint author), USA, Washington, DC 20310 USA. NR 33 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-240-9 J9 MONT MATH ENTHUS MON PY 2009 VL 8 BP 95 EP 126 PG 32 WC Education & Educational Research; Education, Scientific Disciplines; Mathematics; Philosophy SC Education & Educational Research; Mathematics; Philosophy GA BLJ32 UT WOS:000270300900008 ER PT B AU Nelson, J AF Nelson, Jeffery BE Billingham, RP Peters, WA Kobashi, KC TI Reoperations Within the First 30 Days After Pelvic Surgery SO REOPERATIVE PELVIC SURGERY LA English DT Article; Book Chapter ID SMALL-BOWEL OBSTRUCTION; POUCH-ANAL ANASTOMOSIS; LOW ANTERIOR RESECTION; RANDOMIZED CONTROLLED-TRIAL; ABDOMINAL WOUND DEHISCENCE; VACUUM-ASSISTED CLOSURE; RECTAL-CANCER; FOURNIERS GANGRENE; COLORECTAL SURGERY; ABDOMINOPERINEAL RESECTION C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Nelson, J (reprint author), Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. NR 70 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-0-387-89998-5 PY 2009 BP 5 EP 14 DI 10.1007/b14187_2 D2 10.1007/b14187 PG 10 WC Obstetrics & Gynecology; Surgery; Urology & Nephrology SC Obstetrics & Gynecology; Surgery; Urology & Nephrology GA BLA02 UT WOS:000269719900002 ER PT J AU Yu, GL Borlongan, CV Stahl, CE Hess, DC Ou, YL Kaneko, Y Yu, SJ Yang, TL Fang, L Xie, XM AF Yu, Guolong Borlongan, Cesar V. Stahl, Christine E. Hess, David C. Ou, Yali Kaneko, Yuji Yu, Seong Jin Yang, Tianlun Fang, Li Xie, Xiumei TI Systemic delivery of umbilical cord blood cells for stroke therapy: A review SO RESTORATIVE NEUROLOGY AND NEUROSCIENCE LA English DT Review DE Cerebral ischemia; adult stem cells; transplantation; neuroprotection; neurorestoration ID MESENCHYMAL STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; NEURAL PROGENITOR CELLS; CEREBRAL-ISCHEMIA MODEL; MARROW STROMAL CELLS; HUMAN HEMATOPOIETIC STEM; BONE-MARROW; RAT MODEL; IN-VITRO; NEURONAL DIFFERENTIATION AB Purpose: This review paper summarizes relevant studies, discusses potential mechanisms of transplanted cell-mediated neuroprotection, and builds a case for the need to establish outcome parameters that are critical for transplantation success. In particular, we outline the advantages and disadvantages of systemic delivery of human umbilical cord blood (HUCB) cells in the field of cellular transplantation for treating ischemic stroke. Methods: A MEDLINE/PubMed systematic search of published articles in peer-reviewed journals over the last 25 years was performed focusing on the theme of HUCB as donor graft source for transplantation therapy in neurological disorders with emphasis on stroke. Results: Ischemic stroke remains a leading cause of human death and disability. Although stroke survivors may gain spontaneous partial functional recovery, they often suffer from sensory-motor dysfunction, behavioral/neurological alterations, and various degrees of paralysis. Currently, limited clinical intervention is available to prevent ischemic damage and restore lost function in stroke victims. Stem cells from fetal tissues, bone marrow, and HUCB has emerged in the last few years as a potential cell transplant cell source for ischemic stroke, because of their capability to differentiate into multiple cell types and the possibility that they may provide trophic support for cell survival, tissue repair, and functional recovery. Conclusion: A growing number of studies highlight the potential of systemic delivery of HUCB cells as a novel therapeutic approach for stroke. However, additional preclinical studies are warranted to reveal the optimal HUCB transplant regimen that is safe and efficacious prior to proceeding to large-scale clinical application of these cells for stroke therapy. C1 [Yu, Guolong; Ou, Yali; Yang, Tianlun; Fang, Li; Xie, Xiumei] Cent S Univ, Xiangya Hosp, Dept Cardiol, Changsha 410008, Hunan, Peoples R China. [Borlongan, Cesar V.; Hess, David C.; Kaneko, Yuji; Yu, Seong Jin] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA. [Stahl, Christine E.] Dwight D Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA USA. RP Yu, GL (reprint author), Cent S Univ, Xiangya Hosp, Dept Cardiol, Changsha 410008, Hunan, Peoples R China. EM yuguolong123@yahoo.com.cn; cborlongan@mail.mcg.edu RI Kaneko, Yuji/J-6447-2012; OI Borlongan, Cesar/0000-0002-2966-9782 FU National Natural Science Foundation of China; NIH [NINDS 1U01NS055914-01, NINDS 2R42NS055606-02]; MCG Department of Neurology Funds FX Drs. Yu, Ou, Yang, and Fang were funded by the National Natural Science Foundation of China, whereas Drs. Borlongan and Hess were supported by NIH NINDS 1U01NS055914-01, NIH NINDS 2R42NS055606-02, and the MCG Department of Neurology Funds. NR 92 TC 19 Z9 25 U1 0 U2 6 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0922-6028 J9 RESTOR NEUROL NEUROS JI Restor. Neurol. Neurosci. PY 2009 VL 27 IS 1 BP 41 EP 54 DI 10.3233/RNN-2009-0460 PG 14 WC Neurosciences SC Neurosciences & Neurology GA 400NV UT WOS:000262876000004 PM 19164852 ER PT J AU Gumz, JE AF Gumz, Jonathan E. BA Gumz, JE BF Gumz, JE TI The Resurrection and Collapse of Empire in Habsburg Serbia, 1914-1918 Introduction SO RESURRECTION AND COLLAPSE OF EMPIRE IN HABSBURG SERBIA, 1914-1918 SE Cambridge Military Histories LA English DT Editorial Material; Book Chapter C1 [Gumz, Jonathan E.] USN, War Coll, Stennis Space Ctr, MS USA. [Gumz, Jonathan E.] Univ Wisconsin Milwaukee, Milwaukee, WI USA. [Gumz, Jonathan E.] Univ Chicago, Chicago, IL 60637 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-89627-6 J9 CAMBRIDGE MIL HIST PY 2009 BP 1 EP + PG 44 WC History SC History GA BBU11 UT WOS:000308168900001 ER PT J AU Gumz, JE AF Gumz, Jonathan E. BA Gumz, JE BF Gumz, JE TI Facing a Serb Levee en Masse: The Habsburg Army and War on Civilians in 1914 SO RESURRECTION AND COLLAPSE OF EMPIRE IN HABSBURG SERBIA, 1914-1918 SE Cambridge Military Histories LA English DT Article; Book Chapter C1 [Gumz, Jonathan E.] USN, War Coll, Stennis Space Ctr, MS USA. [Gumz, Jonathan E.] Univ Wisconsin Milwaukee, Milwaukee, WI USA. [Gumz, Jonathan E.] Univ Chicago, Chicago, IL 60637 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-89627-6 J9 CAMBRIDGE MIL HIST PY 2009 BP 27 EP 61 PG 35 WC History SC History GA BBU11 UT WOS:000308168900002 ER PT J AU Gumz, JE AF Gumz, Jonathan E. BA Gumz, JE BF Gumz, JE TI Eradicating National Politics in Occupied Serbia SO RESURRECTION AND COLLAPSE OF EMPIRE IN HABSBURG SERBIA, 1914-1918 SE Cambridge Military Histories LA English DT Article; Book Chapter C1 [Gumz, Jonathan E.] USN, War Coll, Stennis Space Ctr, MS USA. [Gumz, Jonathan E.] Univ Wisconsin Milwaukee, Milwaukee, WI USA. [Gumz, Jonathan E.] Univ Chicago, Chicago, IL 60637 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-89627-6 J9 CAMBRIDGE MIL HIST PY 2009 BP 62 EP 104 PG 43 WC History SC History GA BBU11 UT WOS:000308168900003 ER PT J AU Gumz, JE AF Gumz, Jonathan E. BA Gumz, JE BF Gumz, JE TI Legal Severity, International Law, and the Tottering Empire in Occupied Serbia SO RESURRECTION AND COLLAPSE OF EMPIRE IN HABSBURG SERBIA, 1914-1918 SE Cambridge Military Histories LA English DT Article; Book Chapter C1 [Gumz, Jonathan E.] USN, War Coll, Stennis Space Ctr, MS USA. [Gumz, Jonathan E.] Univ Wisconsin Milwaukee, Milwaukee, WI USA. [Gumz, Jonathan E.] Univ Chicago, Chicago, IL 60637 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-89627-6 J9 CAMBRIDGE MIL HIST PY 2009 BP 105 EP 141 PG 37 WC History SC History GA BBU11 UT WOS:000308168900004 ER PT J AU Gumz, JE AF Gumz, Jonathan E. BA Gumz, JE BF Gumz, JE TI Food as Salvation: Food Supply, the Monarchy, and Serbia, 1916-1918 SO RESURRECTION AND COLLAPSE OF EMPIRE IN HABSBURG SERBIA, 1914-1918 SE Cambridge Military Histories LA English DT Article; Book Chapter C1 [Gumz, Jonathan E.] USN, War Coll, Stennis Space Ctr, MS USA. [Gumz, Jonathan E.] Univ Wisconsin Milwaukee, Milwaukee, WI USA. [Gumz, Jonathan E.] Univ Chicago, Chicago, IL 60637 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-89627-6 J9 CAMBRIDGE MIL HIST PY 2009 BP 142 EP 192 PG 51 WC History SC History GA BBU11 UT WOS:000308168900005 ER PT J AU Gumz, JE AF Gumz, Jonathan E. BA Gumz, JE BF Gumz, JE TI A Levee en Masse Nation No More? Guerrilla War in Habsburg Serbia SO RESURRECTION AND COLLAPSE OF EMPIRE IN HABSBURG SERBIA, 1914-1918 SE Cambridge Military Histories LA English DT Article; Book Chapter C1 [Gumz, Jonathan E.] USN, War Coll, Stennis Space Ctr, MS USA. [Gumz, Jonathan E.] Univ Wisconsin Milwaukee, Milwaukee, WI USA. [Gumz, Jonathan E.] Univ Chicago, Chicago, IL 60637 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-89627-6 J9 CAMBRIDGE MIL HIST PY 2009 BP 193 EP 230 PG 38 WC History SC History GA BBU11 UT WOS:000308168900006 ER PT J AU Gumz, JE AF Gumz, Jonathan E. BA Gumz, JE BF Gumz, JE TI The Resurrection and Collapse of Empire in Habsburg Serbia, 1914-1918 Conclusion SO RESURRECTION AND COLLAPSE OF EMPIRE IN HABSBURG SERBIA, 1914-1918 SE Cambridge Military Histories LA English DT Editorial Material; Book Chapter C1 [Gumz, Jonathan E.] USN, War Coll, Stennis Space Ctr, MS USA. [Gumz, Jonathan E.] Univ Wisconsin Milwaukee, Milwaukee, WI USA. [Gumz, Jonathan E.] Univ Chicago, Chicago, IL 60637 USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-89627-6 J9 CAMBRIDGE MIL HIST PY 2009 BP 231 EP 248 PG 18 WC History SC History GA BBU11 UT WOS:000308168900007 ER PT J AU Adams, BD Jones, RJ Delgado, RE Larkin, GL AF Adams, Bruce D. Jones, Robert J. Delgado, Roxana E. Larkin, Gregory Luke CA Amer Heart Assoc Natl Registr TI Cardiac arrests of hospital staff and visitors: Experience from the national registry of cardiopulmonary resuscitation SO RESUSCITATION LA English DT Article DE Automated external defibrillator (AED); Cardiopulmonary resuscitation (CPR); Emergency treatment; Medical Emergency Team; Return of spontaneous circulation; Tracheal intubation; Utstein template; Witnessed cardiac arrest ID PUBLIC-ACCESS DEFIBRILLATION; AUTOMATED EXTERNAL DEFIBRILLATORS; MINUTES COUNT; SURVIVAL; PROGRAM; NURSES; CARE; PROFESSIONALS; AREAS; TEAMS AB Aim of the study: Approximately 750,000 in-hospital cardiac arrests occur annually in the United States. Many will occur to visitors or staff members within the hospital's public areas. We sought to provide a descriptive analysis of visitor cardiac arrests in hospitals and to compare survival outcomes to matching inpatient arrests. Methods: We queried the National Registry of Cardiopulmonary Resuscitation (NRCPR (R)) for all adult cardiac arrests from January 2000 to May 2006 that occurred to visitors or employees anywhere within the hospital. Visitors were matched to inpatient cardiac arrests from within the same NRCPR database for age, gender, race, prior residence and functional status, and presenting rhythms. The compared outcomes were return of spontaneous circulation (ROSC), survival to 24 h (S24), and survival to discharge (SHD). Results: 147 visitors suffered a cardiac arrest during the study period. S24 (48% vs. 37%, p=0.011) and SHD (42% vs. 24%, p<0.0001) were both higher in the visitor cohort. However, ROSC did not significantly differ between visitors and controls (57% vs. 51%). Visitor cardiac arrests occurred in a wide variety of locations. Conclusion: Cardiac arrest among hospital visitors is a relatively common event. The survival outcomes of hospital visitors compared unfavorably to that of recently published experience with out-of-hospital cardiac arrest victims. Published by Elsevier Ireland Ltd C1 [Adams, Bruce D.; Delgado, Roxana E.] William Beaumont Army Med Ctr, Dept Clin Invest, El Paso, TX 79920 USA. [Jones, Robert J.] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA. [Larkin, Gregory Luke] Yale Univ, Sch Med, Dept Surg, Emergency Med Sect, New Haven, CT 06510 USA. RP Adams, BD (reprint author), William Beaumont Army Med Ctr, Dept Clin Invest, 5005 N Piedras St, El Paso, TX 79920 USA. EM bruce.adams@amedd.army.mil NR 39 TC 5 Z9 6 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD JAN PY 2009 VL 80 IS 1 BP 65 EP 68 DI 10.1016/j.resuscitation.2008.09.016 PG 4 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA 395SC UT WOS:000262542800015 PM 19081663 ER PT J AU Bakari, M Aboud, S Nilsson, C Francis, J Buma, D Moshiro, C Aris, EA Lyamuya, E Janabi, M Mbwana, J Mwanyika, L Stout, R Hejdeman, B Brave, A Robb, M Marovich, M Michael, N Earl, P Moss, B Wahren, B Biberfeld, G Pallangyo, K Mhalu, F Sandstrom, E AF Bakari, M. Aboud, S. Nilsson, C. Francis, J. Buma, D. Moshiro, C. Aris, E. A. Lyamuya, E. Janabi, M. Mbwana, J. Mwanyika, L. Stout, R. Hejdeman, B. Brave, A. Robb, M. Marovich, M. Michael, N. Earl, P. Moss, B. Wahren, B. Biberfeld, G. Pallangyo, K. Mhalu, F. Sandstrom, E. TI A low dose of multigene, multiclade HIV DNA given intradermally induces strong and broad immune responses after boosting with heterologous HIV MVA SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Bakari, M.; Aboud, S.; Francis, J.; Moshiro, C.; Lyamuya, E.; Mbwana, J.; Pallangyo, K.; Mhalu, F.] MUHAS, Dar Es Salaam, 20892, Tanzania. [Nilsson, C.; Brave, A.; Wahren, B.; Biberfeld, G.] Swedish Inst Infect Dis Control, Stockholm, Sweden. [Nilsson, C.; Brave, A.; Wahren, B.; Biberfeld, G.] Karolinska Inst, Stockholm, Sweden. [Buma, D.; Aris, E. A.; Janabi, M.] Muhimbili Natl Hosp, Dar Es Salaam, Tanzania. [Mwanyika, L.] Tanzania Police Force, Dar Es Salaam, Tanzania. [Hejdeman, B.; Sandstrom, E.] Soder Sjukhuset, KI, Stockholm, Sweden. [Robb, M.; Marovich, M.; Michael, N.] Walter Reed Army Inst Res, Rockville, MD USA. [Earl, P.; Moss, B.] NIAID, NIH, Bethesda, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P403 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300454 ER PT J AU Beck, Z Karasavvas, N Matyas, GR Alving, CR AF Beck, Z. Karasavvas, N. Matyas, G. R. Alving, C. R. TI Membrane-specific antibodies that simultaneously bind to gp41 of HIV-1 and membrane lipid epitopes are induced by immunization with liposomes SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Beck, Z.] Henry M Jackson Fdn US Mil HIV Res Program, Div Retrovirol, Dept Adjuvant & Antigen Res, Rockville, MD USA. [Karasavvas, N.; Matyas, G. R.; Alving, C. R.] US Mil HIV Res Program, Walter Reed Army Inst Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P174 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300225 ER PT J AU Eller, L Ouma, B Oballah, P Eller, MA de Souza, MS Wabwire-Mangen, F Laeyendecker, O Quinn, T Kiwanuka, N Serwadda, D Sewankambo, N Wawer, M Gray, R Michael, NL Robb, ML Montefiori, D Brown, BK Polonis, VR AF Eller, L. Ouma, B. Oballah, P. Eller, M. A. de Souza, M. S. Wabwire-Mangen, F. Laeyendecker, O. Quinn, T. Kiwanuka, N. Serwadda, D. Sewankambo, N. Wawer, M. Gray, R. Michael, N. L. Robb, M. L. Montefiori, D. Brown, B. K. Polonis, V. R. TI Breadth and magnitude of neutralizing antibody responses in subjects infected with HIV-1 subtype D or recombinants in Rakai district, Uganda SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Eller, L.; Eller, M. A.; Michael, N. L.; Robb, M. L.; Brown, B. K.; Polonis, V. R.] Makerere Univ, Walter Reed Project, US Mil HIV Res Program, Kampala, Uganda. [de Souza, M. S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Wabwire-Mangen, F.; Kiwanuka, N.; Serwadda, D.] Makerere Univ, Walter Reed Makerere Univ, Sch Publ Hlth, Kampala, Uganda. [Laeyendecker, O.; Quinn, T.; Wawer, M.; Gray, R.] NIAID, Johns Hopkins Sch Med, NIH, Baltimore, MD USA. [Sewankambo, N.] Makerere Univ, Coll Hlth Sci, Kampala, Uganda. [Montefiori, D.] Duke Univ, Durham, NC USA. RI Laeyendecker, Oliver/B-9331-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P56 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300109 ER PT J AU Eller, MA Eller, L Koehler, RN Kijak, GH Guwatudde, D Marovich, MA Michael, NL de Souza, MS Wabwire-Mangen, F Robb, ML Currier, JR Sandberg, JK AF Eller, M. A. Eller, L. Koehler, R. N. Kijak, G. H. Guwatudde, D. Marovich, M. A. Michael, N. L. de Souza, M. S. Wabwire-Mangen, F. Robb, M. L. Currier, J. R. Sandberg, J. K. TI Altered NK cell phenotype and function in Ugandans with chronic HIV-1 infection SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Eller, M. A.; Eller, L.] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Koehler, R. N.; Kijak, G. H.; Marovich, M. A.; Michael, N. L.; Robb, M. L.; Currier, J. R.] US Mil HIV Res Program MHRP, Rockville, MD USA. [Guwatudde, D.; Wabwire-Mangen, F.] Makerere Univ, Sch Publ Hlth, Makerere Univ Walter Reed, Kampala, Uganda. [de Souza, M. S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Sandberg, J. K.] Karolinska Inst, Ctr Infect Med, Stockholm, Sweden. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P143 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300195 ER PT J AU Kaewkungwal, J Pitisuttithum, P Nitayapan, S Khamboonruang, C Khamboonruang, C Thongchareon, P Kunasol, P Benenson, M Kim, J AF Kaewkungwal, J. Pitisuttithum, P. Nitayapan, S. Khamboonruang, C. Khamboonruang, C. Thongchareon, P. Kunasol, P. Benenson, M. Kim, J. TI Assuring data quality of the phase III vaccine trial of ALVAC vaccine priming and AIDSVAX vaccine boosting in Thailand SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Kaewkungwal, J.; Pitisuttithum, P.; Thongchareon, P.] Mahidol Univ, Fac Trop Med, Dept Trop Hyg, Bangkok, Thailand. [Nitayapan, S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Khamboonruang, C.; Khamboonruang, C.; Kunasol, P.] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Benenson, M.; Kim, J.] US Mil HIV Res Program, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P215 PG 2 WC Virology SC Virology GA 509KL UT WOS:000271015300266 ER PT J AU Matyas, GR Wieczorek, L Beck, Z Ochsenbauer-Jambor, C Kappes, JC Michael, NL Polonis, VR Alving, CR AF Matyas, G. R. Wieczorek, L. Beck, Z. Ochsenbauer-Jambor, C. Kappes, J. C. Michael, N. L. Polonis, V. R. Alving, C. R. TI Neutralizing antibodies induced by immunization with liposomal gp41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Matyas, G. R.; Michael, N. L.; Polonis, V. R.; Alving, C. R.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. [Wieczorek, L.; Beck, Z.] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. [Ochsenbauer-Jambor, C.; Kappes, J. C.] Univ Alabama, Vet Affairs Med Ctr, Birmingham, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P80 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300132 ER PT J AU Nilsson, C Aboud, S Karlen, K Marovich, M Wahren, B Sandstrom, E Gaines, H Biberfeld, G Godoy-Ramirez, K AF Nilsson, C. Aboud, S. Karlen, K. Marovich, M. Wahren, B. Sandstrom, E. Gaines, H. Biberfeld, G. Godoy-Ramirez, K. TI Strong HIV-specific CD4 and CD8 T-lymphocyte proliferation in HIV-1 DNA prime/modified vaccinia virus Ankara (MVA) SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Nilsson, C.; Karlen, K.; Wahren, B.; Gaines, H.; Biberfeld, G.; Godoy-Ramirez, K.] Karolinska Inst, Swedish Inst Infect Dis Control, Solna, Sweden. [Aboud, S.] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Marovich, M.] Walter Reed Army Inst Res, Rockville, MD USA. [Sandstrom, E.] Venhalsan & Karolinska Inst, Stockholm, Sweden. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR O26 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300027 ER PT J AU Peachman, K Wieczorek, L Polonis, VR Alving, CR Rao, M AF Peachman, K. Wieczorek, L. Polonis, V. R. Alving, C. R. Rao, M. TI Analysis of the binding of multiple clades of HIV-1 by a modified virus capture assay SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Peachman, K.; Wieczorek, L.] Henry M Jackson Fdn USMHRP, DAAR, Rockville, MD USA. [Polonis, V. R.; Alving, C. R.; Rao, M.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P47 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300100 ER PT J AU Weaver, KL Peachman, KK Boonnak, K Wieczorek, L Matyas, GR Asher, LM Polonis, VR Marovich, M Alving, CR Rao, M AF Weaver, K. L. Peachman, K. K. Boonnak, K. Wieczorek, L. Matyas, G. R. Asher, L. M. Polonis, V. R. Marovich, M. Alving, C. R. Rao, M. TI Multispecific monoclonal antibodies bind to primary human macrophages and induce the production of protective chemokines, MIP-1 alpha and MIP-1 beta SO RETROVIROLOGY LA English DT Meeting Abstract C1 [Weaver, K. L.; Peachman, K. K.; Boonnak, K.; Wieczorek, L.; Asher, L. M.] US Mil HIV Res Program, Rockville, MD USA. [Matyas, G. R.; Polonis, V. R.; Marovich, M.; Alving, C. R.; Rao, M.] Walter Reed Army Inst Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-4690 J9 RETROVIROLOGY JI Retrovirology PY 2009 VL 6 AR P50 PG 1 WC Virology SC Virology GA 509KL UT WOS:000271015300103 ER PT S AU Brush, ER Adams, DE Zwink, BR Walsh, S AF Brush, E. R. Adams, D. E. Zwink, B. R. Walsh, S. BE Thompson, DO Chimenti, DE TI PASSIVE HEALTH MONITORING COUPLED WITH FULL-FIELD ACTIVE INSPECTION OF MULTI-LAYERED COMPOSITE ARMOR STRUCTURES SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOLS 28A AND 28B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 35th Annual Review of Progress in Quantitative Nondestructive Evaluation CY JUL 20-25, 2008 CL Univ Chicago, Chicago, IL HO Univ Chicago DE Structural Health Monitoring; Passive Damage Detection; Impact Identification; Nonlinear Frequency Modulation AB This paper presents the results of implementing vibration based damage detection techniques for in situ monitoring and offline nondestructive evaluation of composite armor materials. It is shown that exogenous impact forces can be passively detected, located, and quantified for specimens that were fabricated using woven S-2 glass, elastomer, and carbon fiber sandwich simulated multi-layered armor. Damaging impact energies are applied to test specimens and the passively measured frequency response of the armor is used to update the dynamic model of the specimen and subsequently estimate the level of damage incurred. The forced response of the material at the damaged region is investigated. It is shown that the material damping and stiffness in the damaged region exhibit nonlinearities. A laser Doppler vibrometer is also utilized to show that nonlinear frequency modulation techniques are useful for damage inspection. C1 [Brush, E. R.; Adams, D. E.; Zwink, B. R.] Purdue Univ, Dept Mech Engn, W Lafayette, IN 47906 USA. [Walsh, S.] US Army, Res Lab, APG, Aberdeen Proving Ground, MD USA. RP Brush, ER (reprint author), Purdue Univ, Dept Mech Engn, W Lafayette, IN 47906 USA. FU Army Research Office FX The authors acknowledge the Army Research Office with Dr. Bruce LaMattina as program manager for supporting this work. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0629-2 J9 AIP CONF PROC PY 2009 VL 1096 BP 1083 EP + PG 2 WC Materials Science, Characterization & Testing; Physics, Applied SC Materials Science; Physics GA BKO01 UT WOS:000268740800137 ER PT S AU Brennan, RE Green, WH Sands, JM Yu, JH AF Brennan, R. E. Green, W. H. Sands, J. M. Yu, J. H. BE Thompson, DO Chimenti, DE TI NONDESTRUCTIVE EVALUATION (NDE) OF DAMAGED STRUCTURAL CERAMICS SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOLS 28A AND 28B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 35th Annual Review of Progress in Quantitative Nondestructive Evaluation CY JUL 20-25, 2008 CL Univ Chicago, Chicago, IL HO Univ Chicago DE Nondestructive Evaluation; Ultrasound; Digital Radiography; Imaging; Impact Damage AB A combination of destructive and nondestructive testing methods was utilized to evaluate the impact velocity and energy conditions that caused fracture in alumina structural ceramics. Drop tower testing was used for low velocity impact with a high mass indenter and fragment simulating projectile testing was used for high velocity impact with a low mass projectile. The damaged samples were nondestructively evaluated using digital radiography and ultrasound C-scan imaging. The bulk damage detected by these techniques was compared to surface damage observed by visual inspection. C1 [Brennan, R. E.; Green, W. H.; Sands, J. M.; Yu, J. H.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Brennan, RE (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0629-2 J9 AIP CONF PROC PY 2009 VL 1096 BP 1091 EP 1098 PG 8 WC Materials Science, Characterization & Testing; Physics, Applied SC Materials Science; Physics GA BKO01 UT WOS:000268740800138 ER PT S AU Green, WH Carter, RH AF Green, W. H. Carter, R. H. BE Thompson, DO Chimenti, DE TI EVALUATION OF BALLISTIC DAMAGE IN AN ENCAPSULATED CERAMIC PANEL VIA X-RAY COMPUTED TOMOGRAPHY SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOLS 28A AND 28B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 35th Annual Review of Progress in Quantitative Nondestructive Evaluation CY JUL 20-25, 2008 CL Univ Chicago, Chicago, IL HO Univ Chicago DE Computed Tomography; Nondestructive Evaluation/Testing (NDE/NDT); Ceramics; Encapsulated; Damage AB X-ray computed tomography (XCT) is an important non-destructive evaluation technique for revealing the spatial distribution of ballistically-induced damage in ceramics. The level of detection and resolution of damage depends on the size of the sample and the parameters of the XCT approach (e.g., focal spot size, magnification, etc.). Previous and ongoing work in this area includes assessment of ballistically induced damage in both individual ceramic targets and ceramic armor panels. Ballistic damage in an encapsulated ceramic armor panel with a metal backing has been scanned and extensively evaluated using XCT 2-D and 3-D analysis. The purpose of using XCT evaluation in this study was to better characterize and understand all of the detectable damage. This information can be used to correlate damage features and types with the physical processes of damage initiation and growth. XCT scans and analyses of damage in the panel will be shown and discussed. This will include virtual 3-D solid visualizations and some quantitative analysis of damage features. C1 [Green, W. H.; Carter, R. H.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Green, WH (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 2 TC 0 Z9 0 U1 2 U2 3 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0629-2 J9 AIP CONF PROC PY 2009 VL 1096 BP 1099 EP 1106 PG 8 WC Materials Science, Characterization & Testing; Physics, Applied SC Materials Science; Physics GA BKO01 UT WOS:000268740800139 ER PT S AU Schmidt, KF Little, JR Ellingson, WA Green, W AF Schmidt, K. F., Jr. Little, J. R., Jr. Ellingson, W. A. Green, W. BE Thompson, DO Chimenti, DE TI A PORTABLE MICROWAVE INTERFERENCE SCANNING SYSTEM FOR NONDESTRUCTIVE TESTING OF MULTI-LAYERED DIELECTRIC MATERIALS SO REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION, VOLS 28A AND 28B SE AIP Conference Proceedings LA English DT Proceedings Paper CT 35th Annual Review of Progress in Quantitative Nondestructive Evaluation CY JUL 20-25, 2008 CL Univ Chicago, Chicago, IL HO Univ Chicago DE Microwave; NDT; Ceramics; Composites AB A portable, microwave interference scanning system, that can be used in situ, with one-sided, non-contact access, has been developed. It has demonstrated capability of damage detection on composite ceramic armor. Specimens used for validation included specially fabricated surrogates, and non-ballistic impact-damaged specimens. Microwave data results were corroborated with high resolution direct-digital x-ray imaging. Microwave interference scanning detects cracks, laminar features and material properties variations. This paper will present details of the system and discuss results obtained. C1 [Schmidt, K. F., Jr.; Little, J. R., Jr.] Evisive Inc, Baton Rouge, LA USA. [Ellingson, W. A.] Argonne Natl Lab, Argonne, IL USA. [Green, W.] Army Res Lab, Aberdeen Proving Ground, MD USA. RP Schmidt, KF (reprint author), Evisive Inc, Baton Rouge, LA USA. FU US Army RDECOM ARL; US Army RDECOM TARDEC FX This work is supported by the US Army RDECOM ARL and US Army RDECOM TARDEC whose staffs insight and technical contribution is much appreciated. NR 8 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0629-2 J9 AIP CONF PROC PY 2009 VL 1096 BP 1107 EP + PG 2 WC Materials Science, Characterization & Testing; Physics, Applied SC Materials Science; Physics GA BKO01 UT WOS:000268740800140 ER PT S AU Weiss, CA Morefield, SW Malone, PG Koenigstein, ML AF Weiss, Charles A., Jr. Morefield, Sean W. Malone, Philip G. Koenigstein, Michael L. BE LHostis, V Gens, R Galle, C TI ROLE OF REACTIVE VITREOUS COATINGS IN REINFORCED CONCRETE IN NUCLEAR PLANT CONSTRUCTION SO RILEM WORKSHOP ON LONG-TERM PERFORMANCE OF CEMENTITIOUS BARRIERS AND REINFORCED CONCRETE IN NUCLEAR POWER PLANTS AND WASTE MANAGEMENT SE RILEM Proceedings LA English DT Proceedings Paper CT RILEM Workshop on Long-Term Performance of Cementitious Barriers and Reinforced Concrete in Nuclear Power Plants CY MAR 30-APR 02, 2009 CL Cadarache, FRANCE SP RILEM, European Federat Corrision, OECD, Nucl Energy Agcy AB Reinforced concrete is the basic construction material in commercial nuclear power plants in the United States. The continued performance of these critical concrete structures is necessary to ensure the safety of plant personnel and the public in the surrounding area. Designs for complex concrete and steel structures such as containment domes, where steel frames and steel reinforcement have to bond securely to the surrounding concrete, encounter the problem making concrete adhere to steel. Concrete condition surveys conducted at nuclear power plants have shown that problems can develop at nuclear plants during operations that are typical of aging reinforced concrete structural members. Corrosion of the embedded steel is especially a problem where the concrete is exposed to moisture and oxygen can diffuse down to the concrete-steel interface and cause rust formation, expansion and cracking. The recent development of new engineered coatings for reinforcing steel that are based on using an alkali-resistant vitreous enamel to coat the steel and to fuse reactive calcium silicates and aluminates to the surface of the steel can be used to address both the bonding and the corrosion problem in reinforced concrete C1 [Weiss, Charles A., Jr.] USA, Corps Engineers, Engineers Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Weiss, CA (reprint author), USA, Corps Engineers, Engineers Engineer Res & Dev Ctr, Vicksburg, MS USA. NR 19 TC 0 Z9 0 U1 0 U2 2 PU R I L E M PUBLICATIONS PI BAGNEUX PA 157 RUE DES BLAINS, 92220 BAGNEUX, FRANCE SN 1461-1147 BN 978-2-35158-072-1 J9 RILEM PROC PY 2009 VL 64 BP 287 EP 294 PG 8 WC Construction & Building Technology; Engineering, Environmental; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA BVJ48 UT WOS:000291665400031 ER PT S AU Ashby, S AF Ashby, S. BE Brebbia, CA TI Impacts of hydrology and hydropower on water quality in reservoir tailwaters SO RIVER BASIN MANAGEMENT V SE WIT Transactions on Ecology and the Environment LA English DT Proceedings Paper CT 5th International Conference on River Basin Management CY 2009 CL MALTA DE dams; reservoirs; tailwaters; water quality AB Reservoirs alter riverine dynamics and can impact the water quality of the natural system. As demands for surface water Supplies and hydropower increase, Understanding the potential changes to riverine systems with construction and operation of darns is critical for decision-making in river basin management. This paper will utilize information from selected case studies to 1) overview the impacts of darns on river hydrology and water quality, and 2) provide tools used to mitigate impacts. For example, major changes to the natural hydrograph (e.g., dampening of storms, flow fluctuations associated with hydropower) will be summarized using examples of alterations to the downstream floodplain and channel hydrology and tools used in restoration actions. Changes in water quality in reservoir releases associated with retention and outlet works (e.g., temperature modifications, decreases in dissolved oxygen, and mobilization of nutrients and metals) will be reviewed. Case studies are used to describe downstream dissolved oxygen dynamics Such as sag and recovery and associated impacts on the kinetics of nutrients and metals. Transport, oxidation kinetics, and fate of dissolved nitrogen species (ammonia and nitrate) and metals (iron and manganese) are summarized using data from field and laboratory, studies Techniques such as selective withdrawal, aeration, oxygenation, and use of weirs to mitigate water quality impacts are presented. Lastly, effects throughout the river system associated with Multiple reservoirs (e.g. heat budgets and water supply) are discussed. C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Ashby, S (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. NR 8 TC 0 Z9 0 U1 5 U2 18 PU WIT PRESS PI SOUTHAMPTON PA ASHURST LODGE, SOUTHAMPTON SO40 7AA, ASHURST, ENGLAND SN 1743-3541 BN 978-1-84564-198-6 J9 WIT TRANS ECOL ENVIR JI WIT Trans. Ecol. Environ. PY 2009 VL 124 BP 55 EP 66 DI 10.2495/RM090061 PG 12 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA BMU65 UT WOS:000273610400006 ER PT J AU Blank, S AF Blank, Stephen TI Putin's Presidency and Russian History SO RUSSIAN HISTORY-HISTOIRE RUSSE LA English DT Article DE Hellie; service state; patrimonial autocracy; Muscovite; Russian military; FSB; succession struggless AB The regime crafted by Vladimir Putin and extended now with the election of Dmitry Medvedev in many ways represents a continuation of the Muscovite paradigm delineated by Professor Hellie in his earlier work. Indeed, we are witnessing the consolidation of a fourth version of the Muscovite service state and in the military a kind of serfdom still reigns. This continuity is not just a question of the autocracy of the Tsar but also of the tenuous situation regarding property rights which are not fully established. Furthermore, it is quite clear that government is still a service state where officials' income, power and status derive from the service they render the Tsar and their ability to provide the state's requirements in key industries. just as this elite may be considered a rent-seeking elite, so may the state be considered a rent-granting state that grants them rents in the form of office so that they can provide for themselves at the same time as they serve the Tsar. C1 USA, War Coll, Strateg Studies Inst, Washington, DC USA. RP Blank, S (reprint author), USA, War Coll, Strateg Studies Inst, Washington, DC USA. EM stephen.blank@us.army.mil NR 84 TC 1 Z9 1 U1 1 U2 5 PU BRILL ACADEMIC PUBLISHERS PI LEIDEN PA PLANTIJNSTRAAT 2, P O BOX 9000, 2300 PA LEIDEN, NETHERLANDS SN 0094-288X J9 RUSS HIST-HIST RUSS JI Russ. Hist.-Hist. Russe PY 2009 VL 36 IS 1 BP 88 EP 116 DI 10.1163/187633109X412311 PG 29 WC History SC History GA 490UW UT WOS:000269533800006 ER PT S AU Ohs, RR Schuster, JW Fung, TY AF Ohs, R. Ryan Schuster, Joseph W. Fung, Tat Y. GP IEEE TI Full Wave Simulation of Radiowave Propagation in Unattended Ground Sensor Networks SO RWS: 2009 IEEE RADIO AND WIRELESS SYMPOSIUM SE IEEE Radio and Wireless Symposium LA English DT Proceedings Paper CT IEEE Radio and Wireless Symposium CY JAN 18-22, 2009 CL San Diego, CA SP IEEE DE Propagation; Simulation; Unattended ground sensors; FDTD AB The moving window finite difference time domain (MWFDTD) method is used to analyze propagation between low to the ground antennas commonly used in wireless unattended ground sensor networks. The propagation path loss at 300 MHz is computed for several terrains exhibiting different degrees of roughness. From the pathloss results, the mean and standard deviation of the path loss distribution are determined as functions of distance from the transmitter. The mean loss is shown to be close to the loss over a flat ground for all roughness values, and the standard deviation is shown to increase with the roughness of the terrain. C1 [Ohs, R. Ryan; Schuster, Joseph W.; Fung, Tat Y.] Remcom Inc, State Coll, PA 16801 USA. [Ohs, R. Ryan; Schuster, Joseph W.; Fung, Tat Y.] US Army RDECOM, CERDEC, Ft Monmouth, NJ 07703 USA. RP Ohs, RR (reprint author), Remcom Inc, State Coll, PA 16801 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2164-2958 BN 978-1-4244-2698-0 J9 IEEE RADIO WIRELESS PY 2009 BP 175 EP + PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BMY58 UT WOS:000273914400045 ER PT J AU Danko, JR Gilliland, WR Miller, RS Decker, CF AF Danko, Janine R. Gilliland, William R. Miller, R. Scott Decker, Catherine F. TI Disseminated Mycobacterium marinum infection in a patient with rheumatoid arthritis receiving infliximab therapy SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SKIN INFECTIONS AB Tumor necrosis factor- inhibitors are important adjunctive therapies for rheumatologic diseases. These agents increase the risk for granulomatous disease. We present a case of a woman with severe rheumatoid arthritis on infliximab who developed multiple nodular skin lesions. Biopsies grew Mycobacterium marinum. New lesions developed through therapy, necessitating surgical debulking. C1 [Danko, Janine R.] USN, Infect Dis Directorate, Viral Rickettsial Dis Dept, Med Res Ctr, Silver Spring, MD 20910 USA. [Gilliland, William R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Miller, R. Scott] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Decker, Catherine F.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. RP Danko, JR (reprint author), USN, Infect Dis Directorate, Viral Rickettsial Dis Dept, Med Res Ctr, 503 Robert Grant Ave,Room 3N25, Silver Spring, MD 20910 USA. EM janine.danko@med.navy.mil NR 16 TC 15 Z9 15 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0036-5548 EI 1651-1980 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 2009 VL 41 IS 4 BP 252 EP 255 AR PII 909259105 DI 10.1080/00365540902774599 PG 4 WC Infectious Diseases SC Infectious Diseases GA 418GP UT WOS:000264137000002 PM 19266397 ER PT J AU Fowler, JE Resio, DT AF Fowler, Jimmy E. Resio, Donald T. TI Cooperation and Innovation Lead to New Causeway System to Offload Vessels SO SEA TECHNOLOGY LA English DT Article C1 [Fowler, Jimmy E.; Resio, Donald T.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Washington, DC USA. RP Fowler, JE (reprint author), USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COMPASS PUBLICATIONS, INC PI ARLINGTON PA 1501 WILSON BLVD., STE 1001, ARLINGTON, VA 22209-2403 USA SN 0093-3651 J9 SEA TECHNOL JI Sea Technol. PD JAN PY 2009 VL 50 IS 1 BP 16 EP + PG 2 WC Engineering, Ocean SC Engineering GA 404KV UT WOS:000263151400005 ER PT S AU Haynes, A Gouma, PI AF Haynes, Aisha Gouma, Pelagia-Irene BE Baraton, MI TI POLYANILINE-BASED ENVIRONMENTAL GAS SENSORS SO SENSORS FOR ENVIRONMENT, HEALTH AND SECURITY: ADVANCED MATERIALS AND TECHNOLOGIES SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Study Institute on Sensors for Environment, Health and Security - Advanced Materials and Technology CY SEP 16-27, 2007 CL Vichy, FRANCE SP NATO DE conducting polymer; environmental sensor; polyaniline ID CELLULOSE-ACETATE; THIN-FILM; ELECTRICAL-CONDUCTIVITY; SENSING CHARACTERISTICS; POLYMER-FILM; COMPOSITES; SENSITIVITY; BLENDS; CO; FABRICATION AB Polyaniline (PANl) is an intrinsically conducting gas sensitive polymer. The responsive nature of PANl to environmental pollutants Such as NO2, CO, SO2 and other greenhouse gases, is highly dependent oil the processing techniques employed. The quality and stability of PANl based sensors have been evaluated by many researchers using various nano-manufacturing techniques to discern the effects oil electrical conductivity, selectivity, and sensitivity to various gas analytes. The focus of this work is to provide a brief review of these sensor technologies and the application of polyaniline for environmental monitoring applications. C1 [Haynes, Aisha] US Army, Res Dev & Engn Command, Fuze Precis & Armanments Technol, Anal & Evaluat Technol, Picatinny Arsenal, NJ 07806 USA. [Gouma, Pelagia-Irene] SUNY Stony Brook, Dept Mat Sci & Engn, Stony Brook, NY 11794 USA. RP Haynes, A (reprint author), US Army, Res Dev & Engn Command, Fuze Precis & Armanments Technol, Anal & Evaluat Technol, Picatinny Arsenal, NJ 07806 USA. EM aisha.s.haynes@us.army.mil FU U.S. Army Research Development and Engineering Command, Benet Laboratories FX The authors would like to thank the U.S. Army Research Development and Engineering Command, Benet Laboratories for supporting our current efforts on developing a polyaniline-based chemical sensor. NR 35 TC 4 Z9 4 U1 2 U2 5 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-1-4020-9008-0 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2009 BP 451 EP + DI 10.1007/978-1-4020-9009-7_30 PG 4 WC Environmental Sciences; Remote Sensing SC Environmental Sciences & Ecology; Remote Sensing GA BIS94 UT WOS:000262475800030 ER PT S AU Johnsen, R Golde, MF Rosati, RE Pappas, D Skrzypkowski, MP AF Johnsen, R. Golde, M. F. Rosati, R. E. Pappas, D. Skrzypkowski, M. P. BE VanDerZande, WJ TI Optical emissions from the dissociative recombination of N2H+, HCO+, HOC+, and HNC+ SO SEVENTH INTERNATIONAL CONFERENCE ON DISSOCIATIVE RECOMBINATION: THEORY, EXPERIMENTS AND APPLICATIONS (DR2007) SE Journal of Physics Conference Series LA English DT Proceedings Paper CT 7th International Conference on Dissociative Recombination: Theory, Experiments and Applications CY JUL 18-23, 2007 CL Radboud Univ Nijmegen, Ameland, NETHERLANDS SP Fdn Fundamental Res Matter, Fdn PHYSICA, Netherlands Royal Acad Sci HO Radboud Univ Nijmegen ID ELECTRON-ION RECOMBINATION; VIBRATIONAL-EXCITATION; MERGED-BEAM; CO2+ IONS; PRODUCTS; HCN+; COEFFICIENTS; DEPENDENCE; YIELD; H-3+ AB We present recent flowing-afterglow measurements of branching fractions for electronically and vibrationally excited products arising from the dissociative recombination of N2H+, HCO+, HOC+, and HNC+ ions with thermal electrons. State-specific yields were derived by fitting the observed, spatially resolved emission band intensities to models that simulate all ion-chemical processes, recombination, diffusion, and gas mixing. C1 [Johnsen, R.] Univ Pittsburgh, Dept Phys & Astron, Pittsburgh, PA 15260 USA. [Golde, M. F.] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Rosati, R. E.] Smithsonian Astrophys Observ, Cambridge, MA 02138 USA. [Pappas, D.] Army Res Lab, Aberdeen Proving Ground, MD USA. [Skrzypkowski, M. P.] Prometheus Energy Co, Seattle, WA 98168 USA. RP Johnsen, R (reprint author), Univ Pittsburgh, Dept Phys & Astron, Pittsburgh, PA 15260 USA. EM rj@pitt.edu FU NASA Planetary Atmospheres Program FX This work was, in part, supported by the NASA Planetary Atmospheres Program. NR 31 TC 2 Z9 2 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1742-6588 J9 J PHYS CONF SER PY 2009 VL 192 AR UNSP 012009 DI 10.1088/1742-6596/192/1/012009 PG 9 WC Chemistry, Physical; Physics, Fluids & Plasmas SC Chemistry; Physics GA BTQ61 UT WOS:000287793300009 ER PT J AU Mace, JE Schwacha, MG White, CE Park, MS Chung, KK Holcomb, JB Wolf, SE Wade, CE AF Mace, J. E. Schwacha, M. G. White, C. E. Park, M. S. Chung, K. K. Holcomb, J. B. Wolf, S. E. Wade, C. E. TI THROMBOELASTOGRAPHY AND PLASMA CYTOKINE LEVELS AFTER BURN AND TRAUMA SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 [Mace, J. E.; Schwacha, M. G.; White, C. E.; Park, M. S.; Chung, K. K.; Holcomb, J. B.; Wolf, S. E.; Wade, C. E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 37 EP 38 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000113 ER PT J AU McGrath, S Ryan, K Wendleken, S Rickards, C Convertino, V AF McGrath, S. Ryan, K. Wendleken, S. Rickards, C. Convertino, V. TI PHOTOPLETHYSMOGRAM FEATURES TRACK REDUCTIONS IN CENTRAL BLOOD VOLUME IN A HUMAN MODEL OF PRE-SHOCK HEMORRHAGE SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 [McGrath, S.; Ryan, K.; Wendleken, S.; Rickards, C.; Convertino, V.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 43 EP 44 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000130 ER PT J AU Rickards, C Ryan, K Convertino, V AF Rickards, C. Ryan, K. Convertino, V. TI LIMITATIONS OF HEART PERIOD VARIABILITY FOR MONITORING INDIVIDUAL TRAUMA PATIENTS IN THE PRE-HOSPITAL SETTING SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 [Rickards, C.; Ryan, K.; Convertino, V.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 44 EP 45 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000133 ER PT J AU Ryan, K Rickards, C Ludwig, D Convertino, V AF Ryan, K. Rickards, C. Ludwig, D. Convertino, V. TI TRACKING CENTRAL HYPOVOLEMIA WITH HEART PERIOD VARIABILITY (HPV) IN HUMANS: IMPLICATIONS FOR PATIENT MONITORING SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 [Ryan, K.; Rickards, C.; Ludwig, D.; Convertino, V.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 44 EP 44 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000132 ER PT J AU Darlington, D Scherer, M Miranda, N Kheirabadi, B Dubick, M AF Darlington, D. Scherer, M. Miranda, N. Kheirabadi, B. Dubick, M. TI HYPOCOAGULATION CAUSED BY METABOLIC RESPIRATORY-INDUCED ACIDOSIS IS NOT REVERSED BY PH CORRECTION SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 [Darlington, D.; Scherer, M.; Miranda, N.; Kheirabadi, B.; Dubick, M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 45 EP 46 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000136 ER PT J AU Sethuraman, G Ryan, K Rickards, C Convertino, V AF Sethuraman, G. Ryan, K. Rickards, C. Convertino, V. TI ECTOPIC BEATS IN HEALTHY HUMANS AND TRAUMA PATIENTS: IMPLICATIONS FOR USE OF HEART PERIOD VARIABILITY INDICES IN MEDICAL MONITORING SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 [Sethuraman, G.; Ryan, K.; Rickards, C.; Convertino, V.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 45 EP 45 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000134 ER PT J AU Navarro, L Lima, R Kinsky, M Voigt, R Sondeen, J Dubick, M Salinas, J Kramer, G AF Navarro, L. Lima, R. Kinsky, M. Voigt, R. Sondeen, J. Dubick, M. Salinas, J. Kramer, G. TI VITAL SIGNS MONITORING TO PREDICT BLOOD LOSS DURING ACUTE HEMORRHAGE IN ANESTHETIZED SWINE SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 UTMB, Galveston, TX 77555 USA. USA, Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 47 EP 48 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000141 ER PT J AU Stern, S Rice, J Philbin, N McGwin, G Arnaud, F Johnson, T Flournoy, WS Ahlers, S Pearce, LB McCarron, R Freilich, D AF Stern, Susan Rice, Jennifer Philbin, Nora McGwin, Gerald Arnaud, Francoise Johnson, Todd Flournoy, W. Shannon Ahlers, Stephen Pearce, L. Bruce McCarron, Richard Freilich, Daniel TI RESUSCITATION WITH THE HEMOGLOBIN-BASED OXYGEN CARRIER, HBOC-201, IN A SWINE MODEL OF SEVERE UNCONTROLLED HEMORRHAGE AND TRAUMATIC BRAIN INJURY SO SHOCK LA English DT Article DE Hemoglobin-based oxygen carrier; HBOC-201; hemorrhagic shock; traumatic brain injury; resuscitation ID BOVINE POLYMERIZED HEMOGLOBIN; CEREBRAL-BLOOD-FLOW; HYPERTONIC SALINE DEXTRAN; LACTATED RINGERS SOLUTION; LOW-VOLUME RESUSCITATION; CROSS-LINKED HEMOGLOBIN; CLOSED-HEAD TRAUMA; INTRACRANIAL-PRESSURE; INTRAVASCULAR MACROPHAGES; HYPOTENSIVE RESUSCITATION AB The purpose of this investigation was to compare the effects of initial resuscitation with HBOC-201 to that of lactated Ringer (LR) solution in the setting of uncontrolled hemorrhage and traumatic brain injury (TBI). Anesthetized immature swine underwent fluid-percussion TBI and liver laceration. During a 75-min "prehospital phase," the animals were resuscitated with HBOC-201, LR solution, or nothing (NON). Upon "hospital arrival," the animals were provided blood and 0.9% NaCl as needed, and the liver injury was repaired. Surviving animals were killed 6 h after injury. Brain tissue was processed for blood flow, and gross, light microscopic, and immunohistochemical analyses. Mean TBI force (2.6 +/- 0.6 atm) and blood loss (64.4 +/- 3.4 mL/kg) were similar between groups. Six-hour survival was significantly greater in HBOC-201 (8 of 13 [62%]) versus LR solution (1 of 11 [9%]) and NON (11 of 8 [3%]) animals (P < 0.02). Mean arterial pressures, cardiac indices, cerebral perfusion pressures, and brain tissue oxygen tension were significantly greater, and lactate and base deficit were lower in HBOC-201 as compared with LR solution animals. Blood transfusion requirements were reduced in HBOC-201 (3.6 +/- 0.6 mL/kg per survival hour) as compared to 7.1 +/- 1.2 mL/kg per survival hour. Severity of subarachnoid and intraparenchymal hemorrhages was statistically greater in LR solution-treated animals, but these differences were not likely to be clinically significant. There were no differences in glial fibrillary acidic protein and microtubule-associated protein 2. In this model of combined uncontrolled hemorrhage and TBI, initial resuscitation with HBOC-201 resulted in significant improvements in survival and systemic and cerebrovascular physiological parameters, as well as a reduction in transfusion requirements. C1 [Stern, Susan] Univ Michigan, Dept Emergency Med, Ann Arbor, MI 48109 USA. [Rice, Jennifer; Philbin, Nora; Arnaud, Francoise; Johnson, Todd; Ahlers, Stephen; McCarron, Richard; Freilich, Daniel] Naval Med Res Ctr, Silver Spring, MD USA. [McGwin, Gerald] Univ Alabama, Birmingham, AL USA. [Flournoy, W. Shannon] Walter Reed Army Inst Res, Silver Spring, MD USA. [Pearce, L. Bruce] Biopure Corp, Cambridge, MA USA. RP Stern, S (reprint author), Univ Michigan, Dept Emergency Med, TC B1 354,Box 0303,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA. EM suestern@umich.edu FU US Government (Office of Naval Research) [604771N.9595.001.A0315] FX D.F. is a military service member (or employee of the US government). This work was prepared as part of my official duties. Title 17 U.S.C 105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. NR 91 TC 29 Z9 30 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JAN PY 2009 VL 31 IS 1 BP 64 EP 79 DI 10.1097/SHK.0b013e3181778dc3 PG 16 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 385LO UT WOS:000261815900010 PM 18497706 ER PT J AU Cho, SD Holcomb, JB Tieu, BH Englehart, MS Morris, MS Karahan, ZA Underwood, SA Muller, PJ Prince, MD Medina, L Sondeen, J Shults, C Duggan, M Tabbara, M Alam, HB Schreiber, MA AF Cho, S. David Holcomb, John B. Tieu, Brandon H. Englehart, Michael S. Morris, Melanie S. Karahan, Z. Ayhan Underwood, Samantha A. Muller, Patrick J. Prince, M. Dale Medina, Leticia Sondeen, Jill Shults, Christian Duggan, Michael Tabbara, Malek Alam, Hasan B. Schreiber, Martin A. TI REPRODUCIBILITY OF AN ANIMAL MODEL SIMULATING COMPLEX COMBAT-RELATED INJURY IN A MULTIPLE-INSTITUTION FORMAT SO SHOCK LA English DT Article DE Resuscitation; trauma; preclinical trial; shock; femur fracture; multicenter; swine; coagulopathy ID UNCONTROLLED HEMORRHAGIC-SHOCK; FRESH-FROZEN PLASMA; PROTHROMBIN TIME; LACTATED RINGERS; NORMAL SALINE; EARLY COAGULOPATHY; ACUTE TRAUMA; SWINE MODEL; BLOOD-LOSS; RESUSCITATION AB We developed a complex combat-relevant model of abdominal and extremity trauma, hemorrhagic shock, hypothermia, and acidosis. We then simulated injury, preoperative, and operative phases. We hypothesized that this model is reproducible and useful for randomized multicenter preclinical trials. Yorkshire swine were anesthetized, intubated, and instrumented. They then underwent femur fracture, 60% total blood volume hemorrhage, a 30-min shock period, induced hypothermia to 33 degrees C, and hemorrhage volume replacement with 3:1 isotonic sodium chloride solution (NS) at each of three centers. Hemodynamic parameters were measured continuously. Thromboelastography, arterial blood gas, and laboratory values were collected at baseline, after the shock period, and after NS replacement. Thirty-seven animals were used for model development. Eight (21%) died before completion of the study period. Twenty-nine survivors were included in the analysis. MAP (+/- SEM) after the shock period was 32 +/- 2 mmHg and was similar between centers (P = 0.4). Mean pH, base deficit, and lactate levels were 7.29 +/- 0.02, 8.20 +/- 0.65 mmol/L, and 5.29 +/- 0.44 mmol/L, respectively, after NS replacement. These were similar between centers (P > 0.05). Prothrombin time values increased significantly over time at all centers, reflecting a progressive coagulopathy (P < 0.02). Thromboelastography maximum amplitude values were similar among centers (P > 0.05) and demonstrated progressively weakened platelet interaction over time (P < 0.03). Hematocrit was similar after controlled hemorrhage (P = 0.15) and dilution (P = 0.9). The pH, lactate, base deficit, and coagulation tests reflect a severely injured state. A complex porcine model of polytrauma and shock can be used for multi-institutional study with excellent reproducibility. A consistent severe injury profile was achieved, after which experimental interventions can be applied. This is the first report of a reproducible multicenter trauma and resuscitation-related animal model. C1 [Cho, S. David; Tieu, Brandon H.; Englehart, Michael S.; Morris, Melanie S.; Karahan, Z. Ayhan; Underwood, Samantha A.; Muller, Patrick J.; Schreiber, Martin A.] Oregon Hlth & Sci Univ, Div Trauma & Crit Care, Portland, OR 97239 USA. [Holcomb, John B.; Prince, M. Dale; Medina, Leticia; Sondeen, Jill] USA, Inst Surg Res, Houston, TX USA. [Shults, Christian; Duggan, Michael; Tabbara, Malek; Alam, Hasan B.] Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA. RP Cho, SD (reprint author), Oregon Hlth & Sci Univ, Div Trauma & Crit Care, 3181 SW Sam Jackson Pk Rd,L611, Portland, OR 97239 USA. EM chos@ohsu.edu OI Tabbara, Malek/0000-0003-1046-7803 NR 42 TC 40 Z9 41 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JAN PY 2009 VL 31 IS 1 BP 87 EP 96 DI 10.1097/SHK.0b013e3181777ffb PG 10 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 385LO UT WOS:000261815900012 PM 18497710 ER PT J AU Batchinsky, A Black, I Necsoiu, C Jones, J Cancio, L AF Batchinsky, A. Black, I. Necsoiu, C. Jones, J. Cancio, L. TI HEART RATE COMPLEXITY IS DECREASED DURING APNEA AND RESPIRATORY ACIDOSIS SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 [Batchinsky, A.; Black, I.; Necsoiu, C.; Jones, J.; Cancio, L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 89 EP 89 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000258 ER PT J AU Spinella, P Holcomb, J Wade, C Blackbourne, L AF Spinella, P. Holcomb, J. Wade, C. Blackbourne, L. TI PREDICTORS OF MORTALITY FOR PENETRATING INJURIES EXCLUDING ISOLATED HEAD INJURY SO SHOCK LA English DT Meeting Abstract CT 32nd Annual Conference on Shock CY JUN 06-09, 2009 CL San Antonio, TX SP Shock Soc C1 [Spinella, P.; Holcomb, J.; Wade, C.; Blackbourne, L.] USA, Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PY 2009 VL 31 BP 91 EP 92 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 463ND UT WOS:000267438000264 ER PT J AU Stites, N White, J Adams, DE Triplett, M AF Stites, Nick White, Jonathan Adams, Douglas E. Triplett, Matt TI Minimal-sensing, passive force identification techniques for a composite structural missile component SO SHOCK AND VIBRATION LA English DT Article DE Passive; active; load; force; damage; identification; estimation; quantification; frequency response ID IMPACT FORCE; DOMAIN; LOADS AB Structural health monitoring systems are often limited to the use of one sensor due to cost, complexity, and weight restrictions. Therefore, there is a need to develop load and damage identification techniques that utilize only one sensor. Two passive force estimation techniques are investigated in this work. The techniques focus on either the shape or the amplitude of the magnitude of the applied force in the frequency domain. Both techniques iteratively reduce an underdetermined set of equations of motion into many overdetermined systems of equations to solve for the force estimates. The techniques are shown to locate and quantify impulsive impacts with over 97% accuracy and non-impulsive impacts with at least 87% accuracy. A filament-wound rocket motor casing is used as a test structure. Impacts not acting at a specific input degree of freedom are also accurately located depending on the distance away from the modeled input degrees of freedom, and damaging impact forces are quantified by making assumptions about the impulsive nature of the applied force. C1 [Stites, Nick; White, Jonathan; Adams, Douglas E.] Purdue Univ, Ray W Herrick Labs, W Lafayette, IN 47906 USA. [Triplett, Matt] USA, RDECOM, AMSRD AMR PS AM, Redstone Arsenal, AL 35898 USA. RP Adams, DE (reprint author), Purdue Univ, Ray W Herrick Labs, 140 S Intramural Dr, W Lafayette, IN 47906 USA. EM deadams@purdue.edu NR 20 TC 1 Z9 1 U1 1 U2 6 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1070-9622 J9 SHOCK VIB JI Shock Vib. PY 2009 VL 16 IS 2 BP 117 EP 142 DI 10.3233/SAV-2009-0456 PG 26 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 421SC UT WOS:000264377600001 ER PT J AU Su, ZB Peng, W Zhang, ZY Gogos, G Skaggs, R Cheeseman, B Yen, CF AF Su, Zhenbi Peng, Wen Zhang, Zhaoyan Gogos, George Skaggs, Reed Cheeseman, Bryan Yen, Chian Fong TI Experimental investigation of a novel blast wave mitigation device SO SHOCK AND VIBRATION LA English DT Article DE Shock wave; mitigation device; Hopkinson bar ID ATTENUATION; EXPLOSIVES; PROTECTION; AIRBLAST; WALLS AB A novel blast wave mitigation device was investigated experimentally in this paper. The device consists of a piston-cylinder assembly. A shock wave is induced within the cylinder when a blast wave impacts on the piston. The shock wave propagates inside the device and is reflected repeatedly. The shock wave propagation process inside the device lengthens the duration of the force on the base of the device to several orders of magnitude of the duration of the blast wave, while it decreases the maximum pressure over an order of magnitude. Two types of experiments were carried out to study the blast wave mitigation device. The first type of experiments was done with honeycomb structures protected by the blast wave mitigation device. Experimental results show that the device can adequately protect the honeycomb structure. A second type of experiments was done using a Hopkinson bar to measure the pressure transmitted through the blast wave mitigation device. The experimental results agree well with results from a theoretical model. C1 [Su, Zhenbi; Peng, Wen; Zhang, Zhaoyan; Gogos, George] Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. [Skaggs, Reed; Cheeseman, Bryan; Yen, Chian Fong] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, ZY (reprint author), Univ Nebraska, Dept Mech Engn, Lincoln, NE 68588 USA. EM zzhang5@unl.edu FU Army Research Office [W911NF-04-2-0011] FX Financial support for this study by Army Research Office Contract W911NF-04-2-0011 is gratefully acknowledged. NR 15 TC 3 Z9 3 U1 2 U2 9 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1070-9622 J9 SHOCK VIB JI Shock Vib. PY 2009 VL 16 IS 6 BP 543 EP 553 DI 10.3233/SAV-2009-0487 PG 11 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 533AI UT WOS:000272793600001 ER PT S AU Cheeseman, BA Dandekar, DP AF Cheeseman, B. A. Dandekar, D. P. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI NUMERICAL SIMULATIONS OF LATERAL STRESS PROFILES SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE Numerical simulations; coupled eulerian-lagrangian; lateral stress profiles; silicon carbide ID SILICON-CARBIDE; PIEZORESISTANCE GAUGES; COMPRESSION; STRENGTH AB A series of numerical simulations have been conducted to provide insight into the observed lateral stress profiles in shocked silicon carbide reported in [1]. Utilizing a coupled Euler-Lagrange simulation approach, the thin epoxy layer has been included in the model. When utilizing the Johnson-Holmquist ceramic model with the constants published in [2], the two-step structure of the lateral stress measurement has been successfully reproduced. The influence of the epoxy layer on the development of the stress profile will be discussed. Additional simulations of specimens having buffer plates will be performed to simulate the lateral stress profile. C1 [Cheeseman, B. A.; Dandekar, D. P.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Cheeseman, BA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 83 EP 86 PG 4 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100017 ER PT S AU Grinfeld, MA AF Grinfeld, M. A. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI VOIDS AS TRIGGERS OF HOT SPOTS IN SOLIDS SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE hot spots; ignition; solids; insensitive munition AB A characteristic feature of solid agglomerates as compared with liquid energetic materials is the possibility of localizing dissipation and adiabatic heating near inhomogeneities, especially, at crack tips, sharp corners, etc. Inhomogeneities of macroscopic size can be modeled by using a continuum approach which studies the reversible and irreversible effects responsible for generating hot spots. We explore the appearance of stress driven hot spots in a systematic quantitative way. A closed-form analytical solution is obtained for ellipsoidal inclusions in isotropic media. Our model shows that the rate of thermomechanical dissipation of work essentially increases around penny-shaped elliptical voids. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Grinfeld, MA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 7 TC 1 Z9 1 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 201 EP 204 PG 4 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100046 ER PT S AU Baer, MR Root, S Dattelbaum, D Hooks, DE Gustavsen, RL Orler, B Pierce, T Garcia, F Vandersall, K De Fisher, S Travers, B AF Baer, M. R. Root, S. Dattelbaum, D. Hooks, D. E. Gustavsen, R. L. Orler, B. Pierce, T. Garcia, F. Vandersall, K. De Fisher, S. Travers, B. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI SHOCKLESS COMPRESSION STUDIES OF HMX-BASED EXPLOSIVES SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE Isentropic compression; Z accelerator; polymer binders; energetic composites; CTH modeling AB Several HMX-based explosive samples were subjected to shockless compression using Sandia's Z magnetic compression accelerator. A multi-panel ICE configuration containing various thicknesses of energetic composites PBX9501, PBXN9, LX-10 was subjected to ramp loading up to 320 Kbar over 500 ns. A Velocity Interferometer System for Any Reflector (VISAR) was used to measure transmitted wave profile data of particle velocity and forward and backward procedures were used with an optimization method to determine appropriate EOS data. C1 [Baer, M. R.; Root, S.] Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. [Dattelbaum, D.; Hooks, D. E.; Gustavsen, R. L.; Orler, B.; Pierce, T.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA. [Garcia, F.; Vandersall, K.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [De Fisher, S.; Travers, B.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Baer, MR (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. FU US Dept of Energy's NNSA [DE-AC04-94AL85000]; DoD/DOE MOU IMP program FX The authors thank M. Hobbs for his help with the optimization used in the modeling and the assistance of the personnel at the Sandia Z facility. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the US Dept of Energy's NNSA under contract DE-AC04-94AL85000 and funding for this work was supported by the DoD/DOE MOU IMP program. NR 7 TC 2 Z9 2 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 699 EP + PG 2 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100165 ER PT S AU Raftenberg, MN Scheidler, MJ AF Raftenberg, M. N. Scheidler, M. J. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI GAP FORMATIONS IN SIMULATIONS OF SHPB TESTS ON ELASTIC MATERIALS SOFT IN SHEAR SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE split Hopkinson pressure bar; ballistic gelatin; LS-DYNA; interfacial gaps AB The LS-DYNA code was applied to split Hopkinson pressure bar tests on a material at least two orders of magnitude stiffer in dilatation than in shear. Two constitutive models were applied, linear elasticity and a compressible form of Mooney-Rivlin elasticity. The latter was fitted to data from ballistic gelatin. The incident and transmission bars were aluminum. The nominal strain rate was 2500/s. Gaps appeared at the interfaces between the specimen and both bars. Unloading of the specimen and bars accompanied these gaps. The input-velocity rise time was varied to observe pulse shaping effects. Mesh sensitivity and contact-parameter sensitivity studies were performed. C1 [Raftenberg, M. N.; Scheidler, M. J.] USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. RP Raftenberg, MN (reprint author), USA, Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD 21005 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 715 EP 718 PG 4 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100169 ER PT S AU Florando, JN Jiao, T Grunschel, SE Clifton, RJ Lassila, DH Ferranti, L Becker, RC Minich, RW Bazan, G AF Florando, J. N. Jiao, T. Grunschel, S. E. Clifton, R. J. Lassila, D. H. Ferranti, L. Becker, R. C. Minich, R. W. Bazan, G. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI HIGH RATE PLASTICITY UNDER PRESSURE USING A WINDOWED PRESSURE-SHEAR IMPACT EXPERIMENT SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE transverse waves; vanadium; strength ID COMPRESSION; ALUMINUM AB An experimental technique has been developed to study the strength of materials under conditions of moderate pressures and high shear strain rates. The technique is similar to the traditional pressure-shear plate-impact experiments except that window interferometry is used to measure both the normal and transverse particle velocities at a sample-window interface. Experimental and simulation results on vanadium samples backed with a sapphire window show the utility of the technique to measure the flow strength under dynamic loading conditions. The results show that the strength of the vanadium is approximately 600 MPa at a pressure of 4.5 GPa and a plastic strain of 1.7%. C1 [Florando, J. N.; Lassila, D. H.; Ferranti, L.; Becker, R. C.; Minich, R. W.; Bazan, G.] Lawrence Livermore Natl Lab, 7000 E Ave, Livermore, CA 94551 USA. [Jiao, T.; Grunschel, S. E.; Clifton, R. J.] Brown Univ, Div Engn, Providence, RI 02912 USA. [Grunschel, S. E.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Florando, JN (reprint author), Lawrence Livermore Natl Lab, 7000 E Ave, Livermore, CA 94551 USA. RI Becker, Richard/I-1196-2013 FU LLNL Laboratory Directed Research and Development; WCI "Dynamics of Metals" program FX Funding was provided by the LLNL Laboratory Directed Research and Development and the WCI "Dynamics of Metals" programs. The authors would like to thank Hoang Nguyen and Tom Carlson for lithography and etching of the gratings, Johann Lotscher and Philip Ramsey for the vanadium coatings, and Tien Shen for discussions regarding application of the Steinberg-Lund model to vanadium. NR 12 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 723 EP + PG 2 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100171 ER PT S AU Grunschel, SE Clifton, RJ Jiao, T AF Grunschel, S. E. Clifton, R. J. Jiao, T. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI HIGH STRAIN-RATE RESPONSE OF HIGH-PURITY ALUMINUM AT TEMPERATURES APPROACHING MELT SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE Aluminum; high strain rate; high temperature; plasticity ID METALS AB High-temperature, pressure-shear plate impact experiments were conducted to investigate the rate-controlling mechanisms of the plastic response of high-purity aluminum at high strain rates (10(6) s(-1)) and at temperatures approaching melt. Since the melting temperature of aluminum is pressure dependent, and a typical pressure-shear plate impact experiment subjects the sample to large pressures (2 - 7 GPa), a pressure-release type experiment was used to reduce the pressure in order to measure the shearing resistance at temperatures up to 95% of the current melting temperature. The measured shearing resistance was remarkably large (50 MPa at a shear strain of 2.5) for temperatures this near melt. Numerical simulations conducted using a version of the Nemat-Nasser/Isaacs [1] constitutive equation, modified to model the mechanism of geometric softening, appear to capture adequately the hardening/softening behavior observed experimentally. C1 [Grunschel, S. E.; Clifton, R. J.; Jiao, T.] Brown Univ, Div Engn, Providence, RI 02912 USA. [Grunschel, S. E.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Grunschel, SE (reprint author), Brown Univ, Div Engn, Providence, RI 02912 USA. FU NSFMRSEC at Brown University; Lawrence Livermore National Labs FX The authors are grate fill for the support of NSFMRSEC at Brown University and Lawrence Livermore National Labs. NR 5 TC 2 Z9 2 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 949 EP + PG 2 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100225 ER PT S AU Casem, DT Dandekar, DP AF Casem, D. T. Dandekar, D. P. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI RESPONSE OF ALUMINUM 2139-T8 TO SHOCK LOADING SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE 2139 Aluminum; Hugoniot Elastic Limit; shear strength; spall strength AB Plane shock wave experiments have been conducted on an aluminum alloy, Al 2139-T8, to determine its response under high rates of loading. The alloying elements, copper, magnesium, and silver, have been found to increase the strength, fatigue life, and fracture toughness of Al 2139-T8 and mitigate impact induced damage. The present experiments provide measurements of the Hugoniot Elastic Limit (HEL), shear strength, and spall threshold to almost 5 GPa. Longitudinal measurements are made with a VISAR system and shear strength is determined through direct measurements of lateral stress with embedded manganin gages. Preliminary results indicate an HEL of approximately 0.85 GPa and a constant spall-induced pull-back velocity of approximately 180 m/s. The results also show that 2139-T8 aluminum retains its shear strength under shock loading like other aluminum alloys. C1 [Casem, D. T.; Dandekar, D. P.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Casem, DT (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 973 EP 976 PG 4 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100231 ER PT S AU Dandekar, DP Casem, DT Motoyashiki, Y Sato, E AF Dandekar, D. P. Casem, D. T. Motoyashiki, Y. Sato, E. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI SHOCK RESPONSE OF SILICON NITRIDE SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE Shock response; silicon nitride; Hugoniot Elastic Limit; spall strength AB Silicon nitride is suitable for varied applications because its properties can be tailored through processing and doping. The current work presents shock response of silicon nitride marketed as SN282. The density of this material, 3.4 Mg/m(3), exceeds its single crystal density, 3.2 Mg/m(3), due to the presence of lutetium oxide as an additive around 5% by weight in the material. While the average grain size is 3.4 microns, the aspect ratio of the grains exceed 3. Preliminary results of shock wave experiments may be summarized as follows: (1) The Hugoniot Elastic Limit (HEL) of SN282 lies between 10.8 and 11.9 GPa. (2) The magnitude of the inelastic wave velocity just above the HEL is 8.73 km/s, suggesting that inelastic deformation above the HEL is due to shock induced plasticity in the material. (3) The value of the spall strength lies between 0.57 and 0.65 GPa. The spall strength of SN282 remains unchanged even when shocked beyond the HEL to at least 19.2 GPa unlike other brittle ceramics. C1 [Dandekar, D. P.; Casem, D. T.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Motoyashiki, Y.; Sato, E.] Inst Space & Astronaut Sci, Kanagawa 2298510, Japan. RP Dandekar, DP (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 985 EP + PG 2 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100234 ER PT S AU Ciezak, JA Dandekar, DP AF Ciezak, J. A. Dandekar, D. P. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI COMPRESSION AND ASSOCIATED PROPERTIES OF BORON CARBIDE (B4C) SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE boron carbide; diamond anvil cell; shock compression AB The observed loss of shear strength of boron carbide near 22 GPa has been attributed to presence of amorphous material in the shock recovered, and statically/dynamically indented B4C. This work shows presence of amorphization in boron carbide under triaxial stress compression. This evidence is obtained from in-situ measurement of Raman, and infrared vibrational spectra of B4C under hydrostatic and non-hydrostatic pressures. On the other hand, x-ray diffraction measurements show a shift in the compression of B4C around 27 GPa, but no evidence of a loss of crystallinity in the recorded diffraction pattern of B4C to 47 GPa. Our results indicate that shear plays a very dominant role in the stress-induced amorphization of B4C. C1 [Ciezak, J. A.; Dandekar, D. P.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak, JA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 11 TC 1 Z9 1 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 1287 EP 1290 PG 4 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100304 ER PT S AU Ciezak, JA Jenkins, TA Hemley, RJ AF Ciezak, Jennifer A. Jenkins, Timothy A. Hemley, Russell J. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI OPTICAL AND RAMAN MICROSPECTROSCOPY OF NITROGEN AND HYDROGEN MIXTURES AT HIGH PRESSURES SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE nitrogen-hydrogen mixture; diamond anvil cell; Raman spectroscopy ID HELIUM; GPA AB Optical and Raman microspectroscopy measurements performed on N-2:H-2 mixtures to 83 GPa reveal unusual phase behavior and bonding signatures. To pressures of 30 GPa, large deviations in the internal molecular stretching modes (vibrons) of a 2:1 N-2:H-2, mixture relative to those of the pure materials are found. An unusual phase separation is observed near 35 GPa, involving the formation of two distinct solid phases, one rich in both nitrogen and hydrogen and the other an amorphous nitrogen phase. Raman bands attributed to N-N single bonds or polymerized nitrogen were observed at high pressures. C1 [Ciezak, Jennifer A.] USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. [Jenkins, Timothy A.] NIST, Ctr Neutron Res, Gaithersburg, MD 20899 USA. [Hemley, Russell J.] Carnegie Inst Sci, Geophys Lab, Washington, DC 20015 USA. RP Ciezak, JA (reprint author), USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. FU Carnegie/DOE Alliance Center; National Science Foundation FX Support for this project comes in part from the Carnegie/DOE Alliance Center and the National Science Foundation. NR 14 TC 5 Z9 5 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 1291 EP + PG 2 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100305 ER PT S AU Cazamias, JU Bilyk, SR AF Cazamias, J. U. Bilyk, S. R. BE Elert, ML Buttler, WT Furnish, MD Anderson, WW Proud, WG TI CALIBRATING THE JOHNSON-HOLMQUIST CERAMIC MODEL FOR SIC USING CTH SO SHOCK COMPRESSION OF CONDENSED MATTER - 2009, PTS 1 AND 2 SE AIP Conference Proceedings LA English DT Proceedings Paper CT 16th Conference of the American-Physical-Society-Topical-Group on Shock Compression of Condensed Matter CY JUN 28-JUL 03, 2009 CL Nashville, TN SP Amer Phys Soc, Topical Grp DE Silicon carbide; CTH; ceramic; penetration; constitutive models ID PENETRATION; IMPACT AB The Johnson-Holmquist ceramic material model has been calibrated and successfully applied to numerically simulate ballistic events using the Lagrangian code EPIC. While the majority of the constants are "physics" based, two of the constants for the failed material response are calibrated using ballistic experiments conducted on a confined cylindrical ceramic target. The maximum strength of the failed ceramic is calibrated by matching the penetration velocity. The second refers to the equivalent plastic strain at failure under constant pressure and is calibrated using the dwell time. Use of these two constants in the CTH Eulerian hydrocode does not predict the ballistic response. This difference may be due to the phenomenological nature of the model and the different numerical schemes used by the codes. This paper determines the aforementioned material constants for SiC suitable for simulating ballistic events using CTH. C1 [Cazamias, J. U.] Univ Alabama Birmingham, Birmingham, AL 35294 USA. [Bilyk, S. R.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Cazamias, JU (reprint author), Univ Alabama Birmingham, Birmingham, AL 35294 USA. NR 18 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0732-9 J9 AIP CONF PROC PY 2009 VL 1195 BP 1405 EP + PG 2 WC Physics, Condensed Matter SC Physics GA BOG48 UT WOS:000276574100331 ER PT J AU Velo, AP Gazonas, GA Ameya, T AF Velo, Ani P. Gazonas, George A. Ameya, Takanobu TI z-TRANSFORM METHODS FOR THE OPTIMAL DESIGN OF ONE-DIMENSIONAL LAYERED ELASTIC MEDIA SO SIAM JOURNAL ON APPLIED MATHEMATICS LA English DT Article DE Goupillaud-type layered media; transient loading; wave propagation; shock wave; characteristic curves; palindromic polynomial; periodic optimization; validation of numerical codes ID MULTILAYER STRUCTURES; WAVES; INVERSION; EQUATIONS; SYSTEMS; MEMS AB In this work, we develop a finite trigonometric series representation for the stress in a multilayered Goupillaud-type elastic strip subjected to transient Heaviside loading on one end while the other end is held fixed. This representation is achieved by means of the z-transform method and involves the so-called base angles. Generally, different layered designs could share the same set of base angles, and the more layers the design has, the more base angles are expected. Necessary conditions for the base angles and design parameters for any given design are described. As a result of the stress representation, we are able to identify optimal layered designs which provide the smallest stress amplitude. For two- and three-layered designs, for which the coefficients of the stress representation are easy to find, the optimization results are achieved using a custom-made discrete optimization technique applied in [A.P. Velo and G. A. Gazonas, Int. J. Solids Structures, 40 (2003), pp. 6417-6428]. For other layered designs, the optimality conditions are predicted heuristically using pattern recognition and the necessary conditions for the base angles and design parameters. Applications of these optimization results include design improvement in making a nonoptimal design optimal. They are also extended to non-Goupillaud-type layered media with integer layer length ratios. Our results are supported by numerical experiments and provide means to validate numerical optimization codes. C1 [Velo, Ani P.; Ameya, Takanobu] Univ San Diego, Dept Math & Comp Sci, San Diego, CA 92110 USA. [Gazonas, George A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen, MD 21005 USA. RP Velo, AP (reprint author), Univ San Diego, Dept Math & Comp Sci, 5998 Alcala Pk, San Diego, CA 92110 USA. EM avelo@sandiego.edu; gazonas@arl.army.mil; tameya@sandiego.edu OI Gazonas, George/0000-0002-2715-016X FU Short Term Analysis Services (STAS); Faculty Research and Engineering Program (FREP) FX Received by the editors March 4, 2009; accepted for publication (in revised form) May 5, 2009; published electronically July 22, 2009. This research effort was partially sponsored by the Short Term Analysis Services (STAS) and Faculty Research and Engineering Program (FREP), administered by the Battelle Memorial Institute in North Carolina for the U.S. Army Research Laboratory. This work was performed in part by an employee of the U.S. Government or under U.S. Government contract. The U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes. Copyright is owned by SIAM to the extent not limited by these rights. NR 36 TC 10 Z9 10 U1 0 U2 3 PU SIAM PUBLICATIONS PI PHILADELPHIA PA 3600 UNIV CITY SCIENCE CENTER, PHILADELPHIA, PA 19104-2688 USA SN 0036-1399 EI 1095-712X J9 SIAM J APPL MATH JI SIAM J. Appl. Math. PY 2009 VL 70 IS 3 BP 762 EP 788 DI 10.1137/090751608 PG 27 WC Mathematics, Applied SC Mathematics GA 499CC UT WOS:000270193200007 ER PT J AU Chang, MH Pang, T Yong, JM AF Chang, Mou-Hsiung Pang, Tao Yong, Jiongmin TI OPTIMAL STOPPING PROBLEM FOR STOCHASTIC DIFFERENTIAL EQUATIONS WITH RANDOM COEFFICIENTS SO SIAM JOURNAL ON CONTROL AND OPTIMIZATION LA English DT Article DE optimal stopping; random coefficients; dynamic programming principle; backward stochastic partial differential variational inequality; verification theorem ID CONTINUOUS PARAMETER; SYSTEMS AB An optimal stopping problem for stochastic differential equations with random coefficients is considered. The dynamic programming principle leads to a Hamiltion-Jacobi-Bellman equation, which, for the current case, is a backward stochastic partial differential variational inequality (BSPDVI, for short) for the value function. Well-posedness of such a BSPDVI is established, and a veri. cation theorem is proved. C1 [Chang, Mou-Hsiung] USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. [Pang, Tao] N Carolina State Univ, Dept Math, Ctr Res Sci Computat, Raleigh, NC 27695 USA. [Yong, Jiongmin] Univ Cent Florida, Dept Math, Orlando, FL 32816 USA. RP Chang, MH (reprint author), USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. EM mouhsiung.chang@us.army.mil; tpang@unity.ncsu.edu; jyong@mail.ucf.edu FU U. S. Army Research Office [W911NF04-D-0003]; NSF [DMS-0604309] FX This work is supported in part by grant W911NF04-D-0003 from the U. S. Army Research Office and by NSF grant DMS-0604309. NR 29 TC 8 Z9 8 U1 0 U2 2 PU SIAM PUBLICATIONS PI PHILADELPHIA PA 3600 UNIV CITY SCIENCE CENTER, PHILADELPHIA, PA 19104-2688 USA SN 0363-0129 J9 SIAM J CONTROL OPTIM JI SIAM J. Control Optim. PY 2009 VL 48 IS 2 BP 941 EP 971 DI 10.1137/070705726 PG 31 WC Automation & Control Systems; Mathematics, Applied SC Automation & Control Systems; Mathematics GA 441OM UT WOS:000265778500024 ER PT B AU Mentis, AS AF Mentis, Alexander S. GP ACM TI A Robotics API Dialect for Type-Safe Robots: Translating Myro to Ada SO SIGADA 2009: PROCEEDINGS OF THE ACM INTERNATIONAL CONFERENCE ON ADA AND RELATED TECHNOLOGIES LA English DT Proceedings Paper CT ACM International Conference on Ada and Related Technologies CY NOV 01-05, 2009 CL St Petersburg, FL SP ACM SIGAda, ACM SIGCSE, ACM SIGAPP, ACM SIGBED, ACM SIGCAS, ACM SIGPLAN, Ada-Europe, AdaCore, Ellidiss Software & Lockheed Martin DE Undergraduate computer science education; Myro; Scribbler AB In this paper, we present an Ada robotics API designed to be used in teaching undergraduate-level computer science. Our API is inspired by Myro, a Python-based API, but we improve upon Myro's usability, readability, modularity, and documentation by using features of the Ada programming language and the GNAT Programming Studio's documentation generation tool. The encapsulation, abstraction, and data hiding provided by Ada's packages make it easy for beginning programmers to use the API for advanced tasks, while Ada's syntax and readability allow educators to use the underlying code later in a course or curriculum to illustrate more advanced concepts to the same students as their knowledge and experience grow. C1 US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Mentis, AS (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM alexander.mentis@usma.edu NR 4 TC 0 Z9 0 U1 0 U2 0 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036-9998 USA BN 978-1-60558-475-1 PY 2009 BP 91 EP 101 PG 11 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA BQR20 UT WOS:000281598400020 ER PT S AU Jones, K Zheleva, T Vispute, R Hullavarad, S Ervin, M Dhar, S AF Jones, K. Zheleva, T. Vispute, R. Hullavarad, S. Ervin, M. Dhar, S. BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI Epitaxial TAC Films for the Selective Area Growth of SiC SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT 12th International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl Phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE TaC; SiC; selective area growth; AlGaN ID DIODES AB At sufficiently high temperatures PLD deposited TaC films can be grown epitaxially on 4H-SiC (0001) substrates; at lower temperatures the films recrystallize and ball up forming a large number of pinholes. The growth temperature for epitaxy was found to be 1000 degrees C, and it was facilitated by the epitaxial growth of a thin (2 nm) transition layer of hexagonal Ta2C. High temperature annealing produced changes in the surface morphology, caused grain growth, and created pin holes through a recrystallization process in the films deposited at the lower temperatures, while the films deposited at the higher temperatures remained virtually unchanged. Using TEM it is shown that the (0001) basal planes of the hexagonal 4H-SiC and Ta2C phases are aligned, and they were also parallel to the (111) plane in the cubic TaC with the [10 (1) over bar] cubic direction being parallel to the hexagonal [2 (11) over bar0] hexagonal direction. The Ta2C interlayer most likely is formed because its lattice parameter in the basel plane (3.103 angstrom) is intermediate between that of the 4H-SiC (3.08 angstrom) and the TaC (3.150 angstrom). Given that Al.5Ga.5N is lattice matched to TaC, it could be an excellent substrate for the growth of GaN/AlGaN heterostructures. C1 [Jones, K.; Zheleva, T.; Ervin, M.] Army Res Lab SEDD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Vispute, R.; Hullavarad, S.; Dhar, S.] Univ Maryland, Dept Phys, College Pk, MD 20742 USA. RP Jones, K (reprint author), Army Res Lab SEDD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kajones@arl.army.mil; tzheleva@arl.army.mil; vispute@squid.umd.edu; shiva@squid.umd.edu; mervin@arl.army.mil; sdhar@squid.umd.edu NR 3 TC 1 Z9 1 U1 1 U2 1 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 183 EP + PN 1-2 PG 2 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300044 ER PT S AU Jones, KA AF Jones, K. A. BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI Structural Analysis of Off-Axis SiC Planes for the Growth of SiC and AlGaN Films SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE AlGaN films; SiC films; SiC substrates; misfit dislocations; stacking faults ID LIGHT-EMITTING-DIODES AB An orientation relationship between the cubic 3C and nH hexagonal structures was developed to identify low surface energy, close packed, conducive to growth hexagonal semi-polar planes. This was done to identify planes on which micropipe free SiC crystals, and/or hetero-epitaxial AlGaN structures with a reduced piezoelectric field and a smaller lattice mismatch could be grown. The nH (3 (3) over bar 0 2n)(H) and (3 (3) over bar 0 (n) over bar)(H) hexagonal planes, which correspond to the (100)(C) and (11 (1) over bar)(C) cubic planes are identified, and equations are developed to determine their planar structure and packing density to assess whether there is a reasonable chance that high quality material can be grown on these surfaces and whether it is likely that stacking faults will be formed. It is shown that stacking faults will likely form in SiC crystals; it is also shown that good epitaxy of AlGaN films should be possible on these planes although it is likely stacking faults will be formed. C1 Army Res Lab SEDD, Adelphi, MD 20783 USA. RP Jones, KA (reprint author), Army Res Lab SEDD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM kajones@arl.army.mil NR 4 TC 1 Z9 1 U1 0 U2 0 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 369 EP 372 PG 4 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300087 ER PT S AU Cochrane, CJ Lenahan, PM Lelis, AJ AF Cochrane, C. J. Lenahan, P. M. Lelis, A. J. BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI Electrically Detected Magnetic Resonance Studies of Processing Variations in 4H SiC Based MOSFETs SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT 12th International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl Phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE magnetic resonance; device reliability; MOSFET ID SEMICONDUCTORS; RECOMBINATION AB We apply electrically detected magnetic resonance (EDMR) to variously processed 4H SiC MOSFETs from two vendors. Although, the EDMR line shapes observed are nearly the same for vendor I devices subjected to a nitric oxide (NO) anneal and devices without it, the relationship between EDMR and gate voltage differs greatly between these samples. Furthermore, the EDMR response versus gate bias varies dramatically. EDMR results from a third device produced by a second vendor are very different from those provided by the first vendor. This result implies that significantly different defect populations are present in devices fabricated by different vendors. C1 [Cochrane, C. J.; Lenahan, P. M.] Penn State Univ, 101 EES Bldg, University Pk, PA 16802 USA. [Lelis, A. J.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Cochrane, CJ (reprint author), Penn State Univ, 101 EES Bldg, University Pk, PA 16802 USA. EM cjc203@psu.edu; pmlesm@engr.psu.edu; alelis@arl.army.mil NR 6 TC 5 Z9 5 U1 1 U2 3 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 719 EP + PN 1-2 PG 2 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300172 ER PT S AU Habersat, DB Lelis, AJ McGarrity, JM McLean, FB Potbhare, S AF Habersat, D. B. Lelis, A. J. McGarrity, J. M. McLean, F. B. Potbhare, S. BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI The Effect of Nitridation on SiC MOS Oxides as Evaluated by Charge Pumping SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT 12th International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl Phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE MOS; MOSFET; interface traps; oxide traps; charge pumping; nitridation ID TRANSISTORS; INTERFACE AB We have analyzed the effect of post-oxidation nitride anneals (usually with either NO or N2O gases) on SiC MOSFETs. Two 4H:SiC wafers were identically prepared except that one wafer had a nitridation anneal after the gate oxide was formed, while the other was tested as-oxidized. We compared the two processes by making measurements on lateral MOSFETs and MOS capacitors using I-D-V-GS, C-V, and charge pumping. There was no change in either flatband voltage or interface trap density near the valence band, suggesting that the net fixed charge remained constant (within a few 10(11) cm(-2)). However, there was a large shift in the threshold voltage which, when combined with the C-V results, indicates a strong reduction of interface traps near the conduction band of roughly 6.0 x 10(12) cm(-2) by using the nitridation process. The charge pumping measurements also showed a strong reduction of interface traps. Charge pumping measured a trapping density of 2.5 x 10(12) cm(-2) for the as-oxidized samples and 5.3 x 10(11) cm(-2) for the nitrided samples. The frequency-dependence of the charge pumping signal also indicates a spatial distribution of traps, with volumetric trap densities of roughly 1.3 x 10(19) cm(-3) over 25 angstrom on as-oxidized and 3.8 x 10(18) cm(-3) over 19 angstrom for nitrided. C1 [Habersat, D. B.; Lelis, A. J.] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [McGarrity, J. M.; McLean, F. B.] Berkeley Res Associates Inc, Springfield, VA 22150 USA. [Potbhare, S.] Univ Maryland, College Pk, MD 20742 USA. RP Habersat, DB (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dhabersat@arl.army.mil; alelis@arl.army.mil; jmcgarrityarl@yahoo.com; fbarrymc@verizon.net; potbhare@glue.umd.edu NR 15 TC 11 Z9 11 U1 0 U2 4 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 743 EP + PN 1-2 PG 2 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300178 ER PT S AU Lelis, AJ Habersat, D Green, R Goldsman, N AF Lelis, A. J. Habersat, D. Green, R. Goldsman, N. BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI Temperature-Dependence of SiC MOSFET Threshold-Voltage Instability SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT 12th International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl Phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE MOSFET reliability; threshold voltage instability; oxide charge AB We have observed variations in the instability in the threshold voltage, V-T, of SiC metaloxide semiconductor field-effect transistors (MOSFETs) from various sources and/or processes due to gate-bias stressing as a function of temperature. In some cases we see a dramatic increase in the instability with increasing temperature, consistent with interfacial charge trapping or de-trapping. In other cases the temperature response is very slight, and in still other cases we actually see VT instabilities that move in the opposite direction with bias, indicating the presence of mobile ions. C1 [Lelis, A. J.; Habersat, D.; Green, R.] USA, Res Lab, Adelphi, MD 20783 USA. [Goldsman, N.] Univ Maryland, College Pk, MD 20742 USA. RP Lelis, AJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM alelis@arl.army.mil; dhabersat@arl.army.mil; rgreen@arl.army.mil; neil@umd.edu NR 4 TC 20 Z9 20 U1 1 U2 3 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 807 EP + PN 1-2 PG 3 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300194 ER PT S AU Veliadis, V McNutt, T Mccoy, M Hearne, H DeSalvo, G Clarke, C Potyraj, P Scozzie, C AF Veliadis, Victor McNutt, Ty McCoy, Megan Hearne, Harold DeSalvo, Gregory Clarke, Chris Potyraj, Paul Scozzie, Charles BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI 1200-V, 50-A, Silicon Carbide Vertical Junction Field Effect Transistors for Power Switching Applications SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT 12th International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl Phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE JFET; large area; normally-on; high voltage; high current; high power AB High-voltage normally-on VJFETs of 0.19 cm(2) and 0.096 cm(2) areas were manufactured in seven photolithographic levels with no epitaxial regrowth and a single ion implantation event. A self aligned guard ring structure provided edge termination. At a gate bias of -36 V the 0.096 cm(2) VJFET blocks 1980 V, which corresponds to 91% of the 12 mu m drift layer's avalanche breakdown voltage limit. It outputs 25 A at a forward drain voltage drop of 2 V (368 A/cm(2), 735 W/cm(2)) and a gate current of 4 mA. The specific on-resistance is 5.4 m Omega cm(2). The 0.19 cm(2) VJFET blocks 1200 V at a gate bias of -26 V. It outputs 54 A at a forward drain voltage drop of 2 V (378 A/cm(2), 755 W/cm(2)) and a gate current of 12 mA, with a specific on-resistance of 5.6 m Omega cm(2). The VJFETs demonstrated low gate-to-source leakage currents with sharp onsets of avalanche breakdown. C1 [Veliadis, Victor; McNutt, Ty; McCoy, Megan; Hearne, Harold; DeSalvo, Gregory; Clarke, Chris; Potyraj, Paul] Northrop Grumman Adv Technol Lab, Linthicum, MD 21090 USA. [Scozzie, Charles] Army Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Adv Technol Lab, Linthicum, MD 21090 USA. EM victor.veliadis@ngc.com; ty.mcnutt@ngc.com; megan.mccoy@ngc.com; harold.hearne@ngc.com; greg.desalvo@ngc.com; chris.clarke@ngc.com; paul.potyraj@ngc.com; sscozzie@arl.army.mil NR 11 TC 6 Z9 8 U1 2 U2 2 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 1047 EP + PN 1-2 PG 2 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300250 ER PT S AU Green, R Ogunniyi, A Ibitayo, D Koebke, G Morgenstern, M Lelis, A Dickens, C Hull, B AF Green, Ronald Ogunniyi, Aderinto Ibitayo, Dimeji Koebke, Gail Morgenstern, Mark Lelis, Aivars Dickens, Corey Hull, Brett BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI Evaluation of 4H-SiC DMOSFETs for High-Power Electronics Applications SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT 12th International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl Phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE 4H-SiC; DMOSFET; Power Devices; Switching Loss AB In this paper, large area (0.18cm(2)) SiC DMOSFETs with 1.2 kV and 20 A rating are evaluated for power electronic switching applications. A drain-to-source voltage drop V-DS of 2 V at a forward drain current of 20 A (J(D) = 110 A/cm(2)) was obtained and a specific on-resistance of 18 m Omega-cm(2) was extracted at room temperature. The device on-resistance was measured up to 150 degrees C and initially decreases with increasing temperature, but remains relatively flat over the entire temperature range, demonstrating stable device behavior. High voltage blocking of 1.2 kV between 25 degrees C and 150 degrees C is also demonstrated with a gate-to-source voltage V-GS = 0 V. The drain leakage current under reverse bias and high temperature stress is shown to increase from 10 mu A at 25 degrees C to 27 mu A at 150 degrees C while maintaining the full blocking rating of the device. Experimental results from double-pulse clamped inductive load tests are presented demonstrating fast high voltage and high current switching capability. High voltage resistive-switching measurements on parallel connected SiC DMOSFETs were performed with V-DS having rise and fall times of 49 and 74 ns respectively. Thermal camera images taken of parallel connected DMOSFET die during repetitive switching operation with V-DS = 420 V, I-DS = 25 A and a 40% duty cycle shows a 2 degrees C difference in die temperature, which suggests even current sharing and temperature stable device operation. C1 [Green, Ronald; Ogunniyi, Aderinto; Ibitayo, Dimeji; Koebke, Gail; Morgenstern, Mark; Lelis, Aivars] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Dickens, Corey] Morgan State Univ, Baltimore, MD 21251 USA. [Hull, Brett] Cree Inc, Durham, NC 27703 USA. RP Green, R (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM argreen@arl.army.mil; baderinto.ogunniyi@arl.army.mil; cdibitayo@arl.army.mil; dgkoebke@arl.army.mil; emmorgenstern@ari.army.mil; falelis@arl.army.mil; gcdicken1@eng.morgan.edu; hbrett_hull@cree.com NR 4 TC 1 Z9 1 U1 0 U2 1 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 1135 EP + PN 1-2 PG 2 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300272 ER PT S AU Zhang, QC Jonas, C Burk, A Capell, C Young, J Callanan, R Agarwal, A Palmour, J Geil, B Scozzie, C AF Zhang, Qingchun (Jon) Jonas, Charlotte Burk, Al Capell, Craig Young, Jonathan Callanan, Robert Agarwal, Anant Palmour, John Geil, Bruce Scozzie, Charles BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI 4H-SiC Bipolar Junction Transistors with A Current Gain of 108 SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT 12th International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl Phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE SiC; Bipolar Junction Transistor; Current Gain; On-resistance; BVCEO; BVCBO AB 4H-SiC BJTs with a common emitter current gain (beta) of 108 at 25 degrees C have been demonstrated. The high current gain was accomplished by using a base as thin as 0.25 mu m. The current gain decreases at high temperatures but is still greater than 40 at 300 degrees C. The device demonstrates an open emitter breakdown voltage (BVCBO) of 1150 V, and an open base breakdown voltage (BVCEO) of 250 V. A low specific on-resistance of 3.6 m Omega.cm(2) at 25 degrees C was achieved. The BJTs have shown blocking capabilities over a wide range of operating temperatures up to 300 degrees C. C1 [Zhang, Qingchun (Jon); Jonas, Charlotte; Burk, Al; Capell, Craig; Young, Jonathan; Callanan, Robert; Agarwal, Anant; Palmour, John] Cree Inc, 3026 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA. [Geil, Bruce; Scozzie, Charles] Army Res Lab, Adelphi, MD 20783 USA. RP Zhang, QC (reprint author), Cree Inc, 3026 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA. EM Jon_Zhang@cree.com FU Army Research Laboratory in Adelphi, Md [W911NF-04-2-0022] FX This research was funded through the Cooperative Agreement W911NF-04-2-0022 program supported by the Army Research Laboratory in Adelphi, Md. Authors are grateful to Dr. S-H. Ryu for the valuable technical discussion and manuscript reviewing. NR 5 TC 1 Z9 1 U1 0 U2 0 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 1159 EP + PN 1-2 PG 2 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300278 ER PT S AU Kaplan, SL Ogunniyi, A AF Kaplan, Steven L. Ogunniyi, Aderinto BE Suzuki, A Okumura, H Kimoto, T Fuyuki, T Fukuda, K Nishizawa, S TI Reliability Testing of 4H-SiC Bipolar Junction Transistors in Continuous Switching Applications SO SILICON CARBIDE AND RELATED MATERIALS 2007, PTS 1 AND 2 SE Materials Science Forum LA English DT Proceedings Paper CT International Conference on Silicon Carbide and Related Materials CY OCT 14-19, 2007 CL Otsu, JAPAN SP Japan Soc Appl phys, Assoc Promot Elect, Elect & Informat Engn, Ceram Soc Japan, IEEE EDS, Kansai Chapter, IEEJ, Inst Elect, Informat & Commun Engineers, Japanese Assoc Crystal Growth, Surface Sci Soc Japan, Vacuum Soc Japan DE silicon carbide; bipolar; junction; transistor; reliability; switching AB Continued improvement in silicon carbide (SiC) material processing has allowed development of efficient high temperature devices which are uniquely suited to power electronics circuit designs. The 4H-SiC structure has several intrinsic characteristics that facilitate optimal speed and power handling during high temperature device operation. These characteristics include wide bandgap (3.2 eV), high dielectric breakdown (3.5 MV/cm), and high thermal conductivity (4.9 W/cm-K)[1,2]. By combining these properties, SiC bipolar junction transistors (BJTs) can achieve fast, low impedance switching at high voltages (1.2 kV). New generation devices are being developed with increased current handling capability, as well as improved forward voltage characteristics. The device considered here, along with its on-state DC characteristic, is shown in figure 1. The BJTs are approximately 5mm by 5mm, and are nominally rated for a maximum I., of 50A. Measurements on the Tektronix 371 B curve-tracer indicate current gains over 60 at 25 degrees C and roughly 40 at 150 degrees C. These results were obtained at collector currents up to 20A. The base current for BJTs is typically 300 to 800 mA, depending on device temperature and the maximum device current required. In order to meet current handling requirements of up to 80A, as required for power conversion in modern military systems such as the hybrid-electric vehicle (HEV), it is necessary to configure these devices in parallel with minimal external cooling. The resulting switching circuits must therefore be validated for operation at high temperatures (package temperatures of 90 degrees C, and junction temperatures to 150 degrees C). Validation includes characterization of the devices in clamped inductive circuits with devices configured both alone and in parallel over time. Figure 4 shows measurement waveforms obtained during continuous clamped inductive switching. The primary focus of this work is to establish the overall performance and reliability of these newer generation SiC BJTs in power conversion circuits. Failure analysis and critical performance issues, such as current sharing, energy loss, and total reverse recovery charge are addressed. The initial results of the experiments indicate that these SiC switches have the potential to perform reliably in high temperature power conversion. C1 [Kaplan, Steven L.; Ogunniyi, Aderinto] USA, Res Lab, Adelphi, MD 20783 USA. RP Kaplan, SL (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM skaplan@arl.army.mil; aderinto.ogunniyi@arl.army.mil NR 2 TC 0 Z9 0 U1 0 U2 3 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 600-603 BP 1167 EP 1170 PG 4 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA BIX26 UT WOS:000263555300280 ER PT S AU Cochrane, CJ Lenahan, PM Lelis, AJ AF Cochrane, C. J. Lenahan, P. M. Lelis, A. J. BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI Direct Observation of Lifetime Killing Defects in 4H SiC Epitaxial Layers via Spin Dependent Recombination in Transistors SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE recombination centers; lifetime killing defects; ESR; EPR; SDR AB We have identified a magnetic resonance spectrum associated with minority carrier lifetime killing defects in device quality 4H SiC. C1 [Cochrane, C. J.; Lenahan, P. M.] Penn State Univ, University Pk, PA 16802 USA. [Lelis, A. J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Cochrane, CJ (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM pmlesm@engr.psu.edu NR 20 TC 0 Z9 0 U1 0 U2 0 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 299 EP 302 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100071 ER PT S AU Veliadis, V Hearne, H McNutt, T Snook, M Potyraj, P Scozzie, C AF Veliadis, Victor Hearne, Harold McNutt, Ty Snook, Megan Potyraj, Paul Scozzie, Charles BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI VJFET based all-SiC Normally-Off Cascode Switch for High Temperature Power Handling Applications SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE silicon carbide; vertical-channel junction field-effect transistor; cascode switch; normally-off; high temperature; threshold voltage; transconductance AB High-voltage vertical-junction-field-effect-transistors (VJFETs) are typically designed normally-on to ensure low-resistance voltage-control operation at high current-gain. To exploit the high-voltage/temperature capabilities of VJFETs in a normally-off voltage-controlled switch, high-voltage normally-on and low-voltage normally-off VJFETs were connected in the cascode configuration. The cascode gate's threshold voltage decreases from 2.5 V to 2 V as the temperature increases from 25 degrees C to 225 degrees C, while its breakdown voltage increases from -23 V to -19 V. At 300 degrees C. the drain current of the cascode switch is 21.4% of its 25 degrees C value, which agrees well with the reduction of the 4H-SiC electron mobility with temperature. The VJFET based all-SiC cascode switch is normally-off at 300 degrees C, with its threshold voltage shifting from 1.6 V to 0.9 V as the temperature increases from 25 degrees C to 300 degrees C. This agrees well with the measured reduction in VJFET built-in potential. Finally, the reduction in cascode transconductance with temperature follows that of the theoretical 4H-SiC electron mobility. Overall, the measured thermally-induced cascode parameter shifts are in excellent agreement with theory, which signifies fabrication of robust SiC VJFETs for power switching applications C1 [Veliadis, Victor; Hearne, Harold; McNutt, Ty; Snook, Megan; Potyraj, Paul] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Elect Syst, 1212 Winterson Rd, Linthicum, MD 21090 USA. EM victor.veliadis@ngc.com; harold.hearne@ngc.com; ty.mcnutt@ngc.com; megan.snook@ngc.com; paul.potyraj@ngc.com; sscozzie@arl.army.mil NR 6 TC 6 Z9 6 U1 0 U2 1 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 711 EP 714 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100172 ER PT S AU Veliadis, V Hearne, H Stewart, EJ Caldwell, JD Snook, M McNutt, T Potyraj, P Scozzie, C AF Veliadis, Victor Hearne, Harold Stewart, Eric J. Caldwell, Joshua D. Snook, Megan McNutt, Ty Potyraj, Paul Scozzie, Charles BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI Effect of Bipolar Gate-to-drain Current on the Electrical Properties of Vertical Junction Field Effect Transistors SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE silicon carbide; stacking faults; reliability; power JFETs; stressing; degradation; annealing; stacking fault shrinking ID CASCODE AB Electron-hole recombination-induced stacking faults have been shown to degrade the I-V characteristics of SiC power p-n diodes and DMOSFETs with thick drift epitaxial layers. In this paper, we investigate the effect of bipolar gate-to-drain Current on vertical-channel JFETs. The devices have n(-) drift epitaxial layers of 12-mu m and 100-mu m thicknesses, and were stressed at a Fixed gate-to-drain current density of 100 A/cm(2) for 500 hrs and 5 hrs, respectively. Significant gate-to-drain and on-state conduction current degradations were observed after stressing the 100-mu m drift VJFET. Annealing at 350 degrees C reverses the stress induced degradations. After 500 hours of stressing,. the gate-to-source, gate-to-drain, and blocking voltage characteristics of the 12-mu m VJFET remain unaffected. However, the on-state drain Current was 79% of its pro-stress value. Annealing at 350 degrees C has no impact on the post-stress on-state drain Current of the 12-mu m VJFET. This leads us 10 attribute the degradation to a "burn-in" effect. C1 [Veliadis, Victor; Hearne, Harold; Stewart, Eric J.; Snook, Megan; McNutt, Ty; Potyraj, Paul] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Caldwell, Joshua D.] USN, Res Lab, Washington, DC 20375 USA. [Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Elect Syst, 1212 Winterson Rd, Linthicum, MD 21090 USA. EM victor.veliadis@ngc.com; harold.hearne@ngc.com; eric.j.stewart@ngc.com; joshua.caldwell@nrl.navy.mil; megan.snook@ngc.com; ty.mcnutt@ngc.com; gpaul.potyraj@ngc.com; sscozzie@arl.army.mil RI Caldwell, Joshua/B-3253-2008 OI Caldwell, Joshua/0000-0003-0374-2168 NR 11 TC 6 Z9 6 U1 0 U2 0 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 719 EP 722 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100174 ER PT S AU Ryu, SH Dhar, S Haney, S Agarwal, A Lelis, A Geil, B Scozzie, C AF Ryu, Sei-Hyung Dhar, Sarit Haney, Sarah Agarwal, Anant Lelis, Aivars Geil, Bruce Scozzie, Charles BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI Critical Issues for MOS Based Power Devices in 4H-SiC SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE power DMOSFET; threshold voltage; MOS channel; field effect mobility ID DMOSFETS AB In this paper, we present the effects of MOS channel processing on the threshold voltage and the MOS field effect mobility of 4H-SiC MOSFETs. By increasing the p-well doping concentration by two orders of magnitude, the threshold voltage could be shifted positive from 0V to 5 V when a thermal oxide layer with NO post oxidation anneal Was used as the gate dielectric layer. However, a severe degradation of MOS field effect mobility, decreasing from 37 cm(2)/Vs to 5 cm(2)/Vs, was also observed. Using a different processing technique, which uses a deposited oxide layer with an NO anneal, a threshold voltage of 7.5 V and a MOS field effect mobility of 15 cm(2)/Vs could be achieved. A 10 kV, 1 A power DMOSFET was demonstrated with this technique. A DMOSFET turn-off voltage of 5.25 V was measured at room temperature. which shifted to 3.0 V at 250 degrees C, providing acceptable noise margins throughout the operating temperature range. C1 [Ryu, Sei-Hyung; Dhar, Sarit; Haney, Sarah; Agarwal, Anant] Cree Inc, Durham, NC 27703 USA. [Lelis, Aivars; Geil, Bruce; Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. RP Ryu, SH (reprint author), Cree Inc, 4600 Silicon Dr, Durham, NC 27703 USA. EM sei-hyung_ryu@cree.com NR 6 TC 26 Z9 26 U1 0 U2 0 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 743 EP 748 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100180 ER PT S AU Hull, BA Jonas, C Ryu, SH Das, M O'Loughlin, M Husna, F Callanan, R Richmond, J Agarwal, A Palmour, J Scozzie, C AF Hull, Brett A. Jonas, Charlotte Ryu, Sei-Hyung Das, Mrinal O'Loughlin, Michael Husna, Fatima Callanan, Robert Richmond, Jim Agarwal, Anant Palmour, John Scozzie, Charles BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI Performance of 60 A, 1200 V 4H-SiC DMOSFETs SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE power DMOSFET; power semiconductor device; MOS transistor AB Large area (8 mm x 7 mm) 1200 V 4H-SiC DMOSFETs with a specific on-resistance as low as 9 m Omega(.)cm(2) 2 (at V(GS) = 20 V) able to conduct 60 A at a power dissipation of 200 W/cm(2) are presented. On-resistance is fairly stable with temperature, increasing from 11.5 (at VGS 15 V) at 25 degrees C to 14 m Omega(.)cm(2) at 150 degrees C. The DMOSFETs exhibit avalanche breakdown at 1600 V with the gate shorted to the source, although sub-breakdown leakage currents up to 50 mu A are observed at 1200 V and 200 degrees C due to the threshold voltage lowering with temperature. When switched with a clamped inductive load circuit from 65 A conducting to 750 V blocking the turn-on and turn-off energies at 150 degrees C were less than 4.5 mJ. C1 [Hull, Brett A.; Jonas, Charlotte; Ryu, Sei-Hyung; Das, Mrinal; O'Loughlin, Michael; Husna, Fatima; Callanan, Robert; Richmond, Jim; Agarwal, Anant; Palmour, John] Cree Inc, Durham, NC 27703 USA. [Scozzie, Charles] Army Res Lab, Adelphi, MD 20783 USA. RP Hull, BA (reprint author), Cree Inc, 4600 Silicon Dr, Durham, NC 27703 USA. EM brett_hull@cree.com NR 5 TC 17 Z9 17 U1 0 U2 1 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 749 EP 752 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100181 ER PT S AU Habersat, DB Lelis, AJ Potbhare, S Goldsman, N AF Habersat, D. B. Lelis, A. J. Potbhare, S. Goldsman, N. BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI Improvements In SiC MOS Processing As Revealed By Studies of Fixed and Oxide Trap Charge SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE MOSFET; charge separation; interface trap; oxide trap; fixed charge ID INTERFACE TRAPS; TRANSISTORS; RADIATION; MOSFETS; SILICON; VOLTAGE AB In order to improve Silicon Carbide MOSFET device performance, it is important to minimize the on-state losses by improving the effective channel mobility, which can be done by decreasing interfacial charge consisting of interface traps. fixed charge, and oxide traps, which degrade mobility due to Coulombic scattering. This paper considers a method for distinguishing between oxide traps and fixed charge, and discusses how this charge has varied with processing over the last several years. Our results show that, over the period of study, N(F) has trended downward. Also, the number of switching oxide traps, which gives a lower bound for N(ot) appears to have decreased considerably. The trends For improvement in N(F) and Delta N(ot) are promising, but out data suggests that N(F) and N(ot) remain much too high and need to be reduced further to realize significant gains in SiC MOSFET performance. C1 [Habersat, D. B.; Lelis, A. J.] USA, Res Lab, Adelphi, MD 20783 USA. [Potbhare, S.; Goldsman, N.] Univ Maryland, College Pk, MD 20742 USA. RP Habersat, DB (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM daniel.habersat@us.army.mil NR 16 TC 3 Z9 3 U1 1 U2 2 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 769 EP 772 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100186 ER PT S AU Potbhare, S Goldsman, N Akturk, A Lelis, A Green, R AF Potbhare, Siddharth Goldsman, Neil Akturk, Akin Lelis, Aivars Green, Ronald BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI Investigation of On and Off State Characteristics of 4H-SiC DMOSFETs SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE 4H-SiC DMOSFET; on-resistance; device modeling; impact-ionization; avalanche breakdown ID CARBIDE AB We build upon our previous work on 4H SiC lateral MOSFETs to present physics based numerical modeling and characterization of a 4H-SiC DMOSFET operating in ON state, Comparison of simulated ON state characteristics to experiment shows that surface roughness scattering dominates at the operating bias of V(GS)=15V, whereas interface trap density contributes to reducing the inversion charge in the channel and thereby increasing the ON resistance. OFF state performance of the DMOSFET was modeled by considering impact ionization in the device. Excellent leakage characteristics were observed with the device blocking 2kV drain voltage. Impact ionization related breakdown was observed at 2048V drain bias. C1 [Potbhare, Siddharth; Goldsman, Neil; Akturk, Akin] Univ Maryland, College Pk, MD 20742 USA. [Lelis, Aivars; Green, Ronald] USA, Res Lab, Adelphi, MD 20783 USA. RP Potbhare, S (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM potbhare@umd.edu; neil@umd.edu; akturka@umd.edu; alelis@arl.army.mil; rgreen@arl.army.mil NR 4 TC 1 Z9 1 U1 0 U2 1 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 805 EP 808 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100195 ER PT S AU Lelis, AJ Habersat, D Green, R Goldsman, N AF Lelis, A. J. Habersat, D. Green, R. Goldsman, N. BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI Implications of Threshold-Voltage Instability on SiC DMOSFET Operation SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE charge trapping; MOSFET; leakage current; on-state resistance ID MOSFETS AB Although recent fast I-V measurements and Subthreshold analysis reveal that the threshold-voltage instability due to low-field bias stressing at roorn temperature is greater than previously reported when calculated using slower, standard measurements by a parameter analyzer-a result that is consistent with electrons directly tunneling into and out near interfacial oxide traps, this effect will not prevent the use of power SiC DMOSFET switches in power converter applications if certain precautions are followed. Namely, if the threshold voltage is set high enough so that a negative shift in threshold voltage will not increase the leakage current in the off-state, then the primary effect will be to increase the oil-state resistance by decreasing the effective gate voltage. The instability due to ON-state stressing is greater than that for bias stressing alone, but not significantly. For a well behaved device, a 1-hour ON-state stress will result in about a 7 percent increase in conduction losses, which is manageable for power converter applications. C1 [Lelis, A. J.; Habersat, D.; Green, R.] USA, Res Lab, Adelphi, MD 20783 USA. [Goldsman, N.] Univ Maryland, College Pk, MD 20742 USA. RP Lelis, AJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM alelis@arl.army.mil; dahabersat@arl.army.mil; rgreen@arl.army.mil; neil@umd.edu NR 11 TC 5 Z9 5 U1 0 U2 0 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 809 EP 812 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100196 ER PT S AU Yu, LC Cheung, KP Suehle, JS Campbell, JP Sheng, K Lelis, AJ Ryu, SH AF Yu, Liangchun Cheung, Kin P. Suehle, John S. Campbell, Jason P. Sheng, Kuang Lelis, Aivars J. Ryu, Sei-Hyung BE PerezTomas, A Godignon, P Vellvehi, M Brosselard, P TI Channel Hot-Carrier Effect of 4H-SiC MOSFET SO SILICON CARBIDE AND RELATED MATERIALS 2008 SE Materials Science Forum LA English DT Proceedings Paper CT 7th European Conference on Silicon Carbide and Related Materials CY SEP 07-11, 2008 CL Barcelona, SPAIN SP Minist Educ & Cienc, ACCIO, Generalitat Catalunya, ACREO, Aixtron, Cree Inc, Dow Corning, D plus T Microelect, Ion Beam Serv, SiCED, SiCrystal AG DE channel hot-carrier effect; MOSFET; 4H-SiC ID DEPENDENCE AB SiC MOSFET, as power device, can be expected to operate with high drain and high gate voltages, possibly leading to hot-carrier effect. However, hot-carrier degradation in a SiC MOSFET is difficult to detect because the as fabricated devices contain high level of defects. We report, for the first time, evidence of hot-carrier effect in 4H-SiC MOSFET. The result Suggests that hot hole from impact ionization trapped in the oxide is the cause of the channel hot-carrier effect. C1 [Yu, Liangchun; Cheung, Kin P.; Suehle, John S.; Campbell, Jason P.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Yu, Liangchun; Sheng, Kuang] Rutgers State Univ, Piscataway, NJ 08854 USA. [Lelis, Aivars J.] Army Res Lab, Adelphi, MD 20783 USA. [Ryu, Sei-Hyung] Cree Inc, Durham, NC 27703 USA. RP Cheung, KP (reprint author), Natl Inst Stand & Technol, 100 Bur Dr, Gaithersburg, MD 20899 USA. EM liangchun.yu@nist.gov; kpckpc@ieee.org; john.suehle@nist.gov; jason.campbell@nist.gov; ksheng@ece.rutgers.edu; alelis@arl.army.mil; sei-hyung_ryu@cree.com NR 4 TC 2 Z9 2 U1 2 U2 2 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 0255-5476 J9 MATER SCI FORUM PY 2009 VL 615-617 BP 813 EP 816 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Ceramics; Materials Science, Multidisciplinary SC Engineering; Materials Science GA BJH84 UT WOS:000265961100197 ER PT J AU Pierson, JC DiCaudo, DJ AF Pierson, Joseph C. DiCaudo, David J. BE Hall, JC Hall, BJ TI INFECTIONS IN THE DESERT SO SKIN INFECTIONS: DIAGNOSIS AND TREATMENT LA English DT Article; Book Chapter ID CUTANEOUS LEISHMANIASIS; PULMONARY COCCIDIOIDOMYCOSIS; CLINICAL-DIAGNOSIS; LESIONS C1 [Pierson, Joseph C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Pierson, Joseph C.] US Mil Acad, West Point, NY 10996 USA. [DiCaudo, David J.] Mayo Clin, Dept Dermatol & Pathol, Scottsdale, AZ USA. RP Pierson, JC (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-0-521-89729-7 PY 2009 BP 135 EP 149 PG 15 WC Dermatology; Infectious Diseases SC Dermatology; Infectious Diseases GA BCH85 UT WOS:000310222400013 ER PT J AU Andrada, T Lettieri, C Khramtsov, A Holley, A Roop, S Patterson, H AF Andrada, T. Lettieri, C. Khramtsov, A. Holley, A. Roop, S. Patterson, H. TI ACCURACY OF PRESSURE TRANSDUCER AIRFLOW FOR THE DIAGNOSIS OF UPPER AIRWAY RESISTANCE SYNDROME SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Andrada, T.; Lettieri, C.; Khramtsov, A.; Holley, A.; Roop, S.; Patterson, H.] Walter Reed Army Med Ctr, Sleep Disorders Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 1180 BP A385 EP A386 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542001526 ER PT J AU Coddington, N Carr, W Picchioni, D Horovitz, SG Fukunaga, M Duyn, JH Braun, AR Balkin, TJ AF Coddington, N. Carr, W. Picchioni, D. Horovitz, S. G. Fukunaga, M. Duyn, J. H. Braun, A. R. Balkin, T. J. TI ACTIVATION DIFFERENCES DURING ASCENDING AND DESCENDING TRENDS IN A-WAVE POWER WHILE SLEEPING SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Coddington, N.] Thomas Jefferson High Sch Sci & Technol, Alexandria, VA USA. [Coddington, N.; Carr, W.] USN, Med Res Ctr, Silver Spring, MI USA. [Carr, W.; Picchioni, D.; Braun, A. R.] Natl Inst Deafness & Other Commun Disorders, Bethesda, MD USA. [Picchioni, D.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Horovitz, S. G.; Fukunaga, M.; Duyn, J. H.] Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA. RI Duyn, Jozef/F-2483-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 0061 BP A20 EP A20 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542000063 ER PT J AU Collen, J Holley, A Lettieri, C Shah, A Kelly, W Roop, S AF Collen, J. Holley, A. Lettieri, C. Shah, A. Kelly, W. Roop, S. TI IMPACT OF SPLIT-NIGHT VERSUS TRADITIONAL SLEEP STUDIES ON CPAP COMPLIANCE SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Collen, J.; Holley, A.; Lettieri, C.; Shah, A.; Kelly, W.; Roop, S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 0552 BP A181 EP A182 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542000554 ER PT J AU Eliasson, AH Kashani, M Lettieri, C Vernalis, M AF Eliasson, A. H. Kashani, M. Lettieri, C. Vernalis, M. TI CORRELATIONS BETWEEN ACTIVITY AND SLEEP SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Eliasson, A. H.; Kashani, M.; Vernalis, M.] Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, Washington, DC 20307 USA. [Eliasson, A. H.; Kashani, M.; Vernalis, M.] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. [Lettieri, C.] Walter Reed Army Med Ctr, Sleep Disorders Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 1277 BP A417 EP A417 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542001623 ER PT J AU Holley, AB Shah, A Roop, S Kelly, W Lettieri, C AF Holley, A. B. Shah, A. Roop, S. Kelly, W. Lettieri, C. TI A PROSPECTIVE EVALUATION OF TREATMENT OUTCOMES IN MILD OSAS SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Holley, A. B.; Shah, A.; Roop, S.; Kelly, W.; Lettieri, C.] Walter Reed Army Med Ctr, Med Pulm Sleep & Crit Care Serv, Washington, DC 20307 USA. [Kelly, W.] Uniformed Serv Univ Hlth Sci, Gainesville, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 712 BP A232 EP A232 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542001062 ER PT J AU Killgore, DB Killgore, WD Grugle, NL Balkin, TJ AF Killgore, D. B. Killgore, W. D. Grugle, N. L. Balkin, T. J. TI EXECUTIVE FUNCTIONS PREDICT THE ABILITY TO SUSTAIN PSYCHOMOTOR VIGILANCE DURING SLEEP LOSS SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Killgore, D. B.; Killgore, W. D.; Grugle, N. L.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Killgore, W. D.] Harvard Univ, Sch Med, Belmont, MA 02178 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 477 BP A158 EP A158 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542000479 ER PT J AU Killgore, WD Killgore, DB Kamimori, GH Balkin, TJ AF Killgore, W. D. Killgore, D. B. Kamimori, G. H. Balkin, T. J. TI CAFFEINE PROTECTS AGAINST INCREASED RISK-TAKING BEHAVIOR DURING SEVERE SLEEP DEPRIVATION SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Killgore, W. D.; Killgore, D. B.; Kamimori, G. H.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Killgore, W. D.] Harvard Univ, Sch Med, Belmont, MA 02178 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 0473 BP A156 EP A157 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542000475 ER PT J AU Picchioni, D Horovitz, SG Fukunaga, M Carr, WS Balkin, TJ Duyn, JH Braun, AR AF Picchioni, D. Horovitz, S. G. Fukunaga, M. Carr, W. S. Balkin, T. J. Duyn, J. H. Braun, A. R. TI HOW SLOW CAN YOU GO? UNIQUE FMRI CORRELATIONS WITH EEG ACTIVITY BELOW 0.1 HZ DURING SLEEP SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Picchioni, D.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Horovitz, S. G.; Fukunaga, M.; Duyn, J. H.; Braun, A. R.] NIH, Bethesda, MD 20892 USA. [Carr, W. S.] USN, Med Res Ctr, Silver Spring, MD USA. RI Duyn, Jozef/F-2483-2010; Fukunaga, Masaki/F-6441-2013 OI Fukunaga, Masaki/0000-0003-1010-2644 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 0033 BP A11 EP A11 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542000035 ER PT J AU Russo, M Stetz, M Stetz, T AF Russo, M. Stetz, M. Stetz, T. TI THE PREVALENCE OF SLEEP/WAKE DISTURBANCES IN MILD TRAUMATIC BRAIN INJURY PATIENTS SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Russo, M.] Tripler Army Med Ctr, Tripler, HI USA. [Russo, M.] Univ Hawaii, Sch Med, Dept Med, Honolulu, HI 96822 USA. [Russo, M.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Neurol, Bethesda, MD USA. [Stetz, T.] Natl Geospatial Intelligence Agcy, Honolulu, HI USA. [Stetz, M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RI Sanguansri, Luz/B-6630-2011 OI Sanguansri, Luz/0000-0003-1908-7604 NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 SU S MA 0954 BP A311 EP A311 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542001301 ER PT J AU Russo, M Stetz, M Swanson, E Stetz, T AF Russo, M. Stetz, M. Swanson, E. Stetz, T. TI EXCESSIVE DAYTIME SLEEPINESS IN MILD TRAUMATIC BRAIN INJURY (MTBI) PATIENTS SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Russo, M.; Swanson, E.] Tripler Army Med Ctr, Tripler, HI USA. [Russo, M.] Univ Hawaii, Sch Med, Honolulu, HI 96822 USA. [Russo, M.] USUHS Sch Med, Dept Neurol, Bethesda, MD USA. [Stetz, M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Stetz, T.] Natl Geospatial Intelligence Agcy, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 SU S MA 0955 BP A311 EP A311 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542001302 ER PT J AU Shah, A Lettieri, C Holley, A Kelly, W Roop, S AF Shah, A. Lettieri, C. Holley, A. Kelly, W. Roop, S. TI ESZOPICLONE IMPROVES SHORT AND INTERMEDIATE TERM CONTINUOUS POSITIVE AIRWAY PRESSURE COMPLIANCE SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Shah, A.; Lettieri, C.; Holley, A.; Kelly, W.; Roop, S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 0561 BP A184 EP A185 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542000563 ER PT J AU Stetz, A Russo, M Stetz, T AF Stetz, A. Russo, M. Stetz, T. TI A SLEEP SCREENING TOOL FOR MILITARY PERSONNEL: THE POST TRAUMATIC STRESS DISORDER CHECKLIST SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Stetz, A.] Tripler Army Med Ctr, Tripler, HI USA. [Stetz, T.] Natl Geospatial Intelligence Agcy, Honolulu, HI USA. [Russo, M.] Univ Hawaii, Sch Med, Honolulu, HI 96822 USA. [Russo, M.] USUHS Sch Med, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 1087 BP A354 EP A355 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542001434 ER PT J AU Stetz, M Stetz, T Cuff, P Russo, M AF Stetz, M. Stetz, T. Cuff, P. Russo, M. TI INSOMNIA IN MILD TRAUMATIC BRAIN INJURY (MTBI) PATIENTS SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Russo, M.] Tripler Army Med Ctr, Tripler, HI USA. [Russo, M.] Univ Hawaii, Dept Med, Sch Med, Honolulu, HI 96822 USA. [Russo, M.] USUHS Dept Neurol, Dept Neurol, Bethesda, MD USA. [Stetz, T.] Natl Geospatial Intelligence Agcy, Honolulu, HI USA. [Stetz, M.; Cuff, P.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 952 BP A310 EP A310 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542001299 ER PT J AU Torch, W Cardillo, C Russo, M Publicover, N Gutierrez, E McMullen, S Martin, M Parseghian, Z AF Torch, W. Cardillo, C. Russo, M. Publicover, N. Gutierrez, E. McMullen, S. Martin, M. Parseghian, Z. TI OCULOMETRIC INDICES ASSOCIATED WITH DROWSINESS AND PERFORMANCE VIGILANCE IMPAIRMENT IN SLEEP-DEPRIVED NORMAL, SLEEP APNEA, NARCOLEPSY AND ADD/ADHD SUBJECTS SO SLEEP LA English DT Meeting Abstract CT 23rd Annual Meeting of the Associated-Professional-Sleep-Societies CY JUN 06-11, 2009 CL Seattle, WA SP Associated Profess Sleep Soc C1 [Torch, W.; Cardillo, C.; Publicover, N.; Gutierrez, E.; McMullen, S.; Parseghian, Z.] Eye Com Corp, Reno, NV USA. [Torch, W.; Gutierrez, E.; Martin, M.] Washoe Sleep Disorders Ctr, Reno, NV USA. [Russo, M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Publicover, N.] Univ Nevada, Reno, NV 89557 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PY 2009 VL 32 MA 0406 BP A134 EP A135 PG 2 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 438FT UT WOS:000265542000408 ER PT S AU Currano, LJ Gee, D Churaman, W Dubey, M Amirtharaj, P Yu, M Balachandran, B AF Currano, Luke J. Gee, Danny Churaman, Wayne Dubey, Madan Amirtharaj, Paul Yu, Miao Balachandran, Balakumar BE Vincenzini, P Darrigo, G TI MEMS Rotational Actuator for High Force and Large Displacement SO SMART MATERIALS & MICRO/NANOSYSTEMS SE Advances in Science and Technology LA English DT Proceedings Paper CT 3rd International Conference on Smart Materials, Structures and Systems CY JUN 08-13, 2008 CL Acireale, ITALY DE MEMS; actuator; thermal; rotation; rotary; torsion; in-plane ID THERMAL ACTUATORS; DESIGN AB A MEMS thermal actuator that provides rotational or near-linear translational displacements is investigated. This actuator provides a solution to applications that require high-forces and large displacements. Output moments up to 7x10(-7) N-m and free rotations of up to 3 degrees were measured. These correspond to forces of up to 1.44mN at a displacement of 23.7 mu m, yielding a work of 3.41 x 10(-8) N-m. An electrothermal-mechanical model that considers temperature dependence of material properties is presented, and the model predictions show good agreement with actuator test data. C1 [Currano, Luke J.; Gee, Danny; Churaman, Wayne; Dubey, Madan; Amirtharaj, Paul; Yu, Miao; Balachandran, Balakumar] USA, Res Lab, Adelphi, MD 20783 USA. RP Currano, LJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM lcurrano@arl.army.mil; danny.gee@arl.army.mil; wayne.churaman@arl.army.mil; mdubey@arl.army.mil; pamirtharaj@arl.army.mil; mmyu@umd.edu; balab@umd.edu NR 15 TC 0 Z9 0 U1 1 U2 3 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 1662-0356 BN 978-3-908158-20-2 J9 ADV SCI TECH PY 2009 VL 54 BP 372 EP 377 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA BJD42 UT WOS:000265012100056 ER PT S AU Churaman, WA Currano, L Gee, D Zakar, E AF Churaman, Wayne A. Currano, Luke Gee, Danny Zakar, Eugene BE Vincenzini, P Darrigo, G TI Three-Axis MEMS Threshold Accelerometer Switch for Enhanced Power Conservation of MEMS Sensors SO SMART MATERIALS & MICRO/NANOSYSTEMS SE Advances in Science and Technology LA English DT Proceedings Paper CT 3rd International Conference on Smart Materials, Structures and Systems CY JUN 08-13, 2008 CL Acireale, ITALY DE MEMS; accelerometers; threshold; switch; sensor; 3-axis ID DESIGN AB A no-power 3-axis bidirectional MEMS threshold accelerometer is presented in this paper. Threshold accelerometers of 25g, 50g, and 100g were designed and fabricated on a single 3mm chip. The design is based on a conductive spring-mass system made of Au metal layers that close a switch between two metal contacts when the designed threshold is exceeded. We present the MEMS threshold accelerometer switch fabrication process and provide an analytical and experimental framework for the device performance C1 [Churaman, Wayne A.; Currano, Luke; Gee, Danny; Zakar, Eugene] USA, Res Lab, Adelphi, MD 20783 USA. RP Churaman, WA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM wayne.churaman@arl.army.mil; lcurrano@arl.army.mil; danny.gee@arl.army.mil; ezakar@arl.army.mil NR 5 TC 0 Z9 0 U1 2 U2 2 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 1662-0356 BN 978-3-908158-20-2 J9 ADV SCI TECH PY 2009 VL 54 BP 384 EP 389 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA BJD42 UT WOS:000265012100058 ER PT S AU Pellegrino, JM AF Pellegrino, John M. BE Vincenzini, P Darrigo, G TI The Promise of Nano and Micro Systems for Meeting the Emerging Demands of the US Army SO SMART MATERIALS & MICRO/NANOSYSTEMS SE Advances in Science and Technology LA English DT Proceedings Paper CT 3rd International Conference on Smart Materials, Structures and Systems CY JUN 08-13, 2008 CL Acireale, ITALY DE Sensors; MEMS; PZT; nanostrucutres ID FILM PIEZOELECTRIC ACTUATORS AB The rapidly changing defense landscape and the exponential increase in complex challenges and threats faced by our warfighters demand revolutionary advances across the spectrum and even a rethinking of current combat doctrine. Sensors and Electron devices are critical elements in a number of application form providing situational awareness to battlefield operations. Enabling nano and micro system approaches offer the potential to fulfill Army needs in applications such as chemical and biological sensors, high-frequency and low-power electronics, micro autonomous systems, micro power generation, specialized optical sources and detectors and much more. A large part of the advances thus far originate in insights and understanding of the underlying materials. I will review some emerging needs with recent illustrative examples from the field and will follow up with potential solutions that are being developed within ARL and our Army partners. These include RF MEMS for electronically scanned antennas, carbon nanotube and other nanostructure based chemical/biological sensors, biomimetic approaches to materials development for power storage applications and nanostructured semiconductors for integrated electronics and energetics. C1 USA, Res Lab, Adelphi, MD USA. RP Pellegrino, JM (reprint author), USA, Res Lab, Adelphi, MD USA. EM john.m.pellegrino@us.army.mil NR 8 TC 0 Z9 0 U1 1 U2 4 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 1662-0356 BN 978-3-908158-20-2 J9 ADV SCI TECH PY 2009 VL 54 BP 396 EP 400 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA BJD42 UT WOS:000265012100060 ER PT S AU Zakar, E Wikner, D Dubey, M Amirtharaj, P AF Zakar, E. Wikner, D. Dubey, M. Amirtharaj, Paul BE Vincenzini, P Darrigo, G TI Thin Film YBCO Pixels for MMW Detector SO SMART MATERIALS & MICRO/NANOSYSTEMS SE Advances in Science and Technology LA English DT Proceedings Paper CT 3rd International Conference on Smart Materials, Structures and Systems CY JUN 08-13, 2008 CL Acireale, ITALY DE YBCO; etch; MMW; sensor ID BOLOMETERS; SILICON AB This research addresses the fabrication of crack-free 40-nm thin film YBa(2)Cu(3)O(7) (YBCO) Pixel structures based on high temperature superconductor (HTSC) microbolometers for highly sensitive thermal detectors that can be miniaturized for affordable passive millimeter-wave (MMW) imaging. A completely dry etch process is described for suspended transition edge bolometers by removing (releasing) the silicon substrate underneath a 3 micrometer wide pixel using gaseous plasma sulfurhexafluoride (SF(6)) chemical reaction. This is an improvement over conventional selective wet chemical etching techniques that are both harsh on the YBCO and require additional complex alignment steps to the substrate material leading to very poor device yields and performance. Issues relating to material roughness, etch redeposition, and silicon undercutting will be analyzed and methodologies to overcome/minimize such problems will be explained in detail. C1 [Zakar, E.; Wikner, D.; Dubey, M.; Amirtharaj, Paul] USA, Res Lab, Adelphi, MD 20783 USA. RP Zakar, E (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ezakar@arl.army.mil; dwikner@arl.army.mil; mdubey@arl.army.mil; pamirtharaj@arl.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU TRANS TECH PUBLICATIONS LTD PI STAFA-ZURICH PA LAUBLSRUTISTR 24, CH-8717 STAFA-ZURICH, SWITZERLAND SN 1662-0356 BN 978-3-908158-20-2 J9 ADV SCI TECH PY 2009 VL 54 BP 434 EP 438 PG 5 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA BJD42 UT WOS:000265012100067 ER PT B AU Snyder, JF O'Brien, DJ Baechle, DM Mattson, DE Wetzel, ED AF Snyder, James F. O'Brien, Daniel J. Baechle, Daniel M. Mattson, Daniel E. Wetzel, Eric D. GP ASME TI STRUCTURAL COMPOSITE CAPACITORS, SUPERCAPACITORS, AND BATTERIES FOR US ARMY APPLICATIONS SO SMASIS2008: PROCEEDINGS OF THE ASME CONFERENCE ON SMART MATERIALS, ADAPTIVE STRUCTURES AND INTELLIGENT SYSTEMS - 2008, VOL 1 LA English DT Proceedings Paper CT Conference on Smart Materials, Adaptive Structures and Intelligent Systems CY OCT 28-30, 2008 CL Ellicot, MD SP ASME, Nanotechnol Inst ID DIELECTRIC-PROPERTIES; SYSTEMS; DESIGN AB Structural capacitors, supercapacitors, and batteries are fabricated and tested, using modified materials and processes based on conventional fiber-reinforced polymer matrix composites. Printed circuit board prepregs are used to create structural capacitors that demonstrate good dielectric energy density and mechanical stiffness and strength. Structural supercapacitors are created using carbon fabric electrodes and a liquid-plasticized, epoxy polymer electrolyte. A similar construction is used to create structural batteries, by substituting LiFePO(4)-coated carbon fiber fabric as cathodes opposed to unmodified carbon fiber anodes. Structural batteries and supercapacitors show basic electrochemical and mechanical functionality. However, significant additional work is required to improve their quantitative performance to values of practical engineering value. C1 [Snyder, James F.; O'Brien, Daniel J.; Baechle, Daniel M.; Wetzel, Eric D.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Snyder, JF (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 25 TC 0 Z9 0 U1 2 U2 5 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4331-4 PY 2009 BP 1 EP 8 PG 8 WC Computer Science, Artificial Intelligence; Engineering, Mechanical; Materials Science, Multidisciplinary SC Computer Science; Engineering; Materials Science GA BJE63 UT WOS:000265211900001 ER PT J AU Castro, CC AF Castro, Colonel Carl TI Impact of Combat on the Mental Health and Well-Being of Soldiers and Marines SO SMITH COLLEGE STUDIES IN SOCIAL WORK LA English DT Article DE PTSD; Battlemind Training; DSM-IVTR; Combat exposure; risks AB This presentation introduces a summary of leading edge research and recommendations for a number of changes regarding mental health needs and services for Veterans. Those Veterans who experienced combat exposure and those who have perceived their leadership negatively have greater risks for developing subsequent PTSD. Research data provide support for the use of Battlemind Training as a useful approach to prevent mental health issues at all phases of the deployment cycle. The author also challenges the current use of DSM-IVTR diagnoses with combat Veterans. C1 USA, Mil Operat Med Res Program, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Castro, CC (reprint author), USA, Mil Operat Med Res Program, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM castro.carl1@gmail.com NR 4 TC 5 Z9 5 U1 1 U2 4 PU HAWORTH PRESS INC PI BINGHAMTON PA 10 ALICE ST, BINGHAMTON, NY 13904-1580 USA SN 0037-7317 J9 SMITH COLL STUD SOC JI Smith Coll. Stud. Soc. Work PY 2009 VL 79 IS 3-4 BP 247 EP 262 AR PII 916163794 DI 10.1080/00377310903130290 PG 16 WC Social Work SC Social Work GA 524IL UT WOS:000272136900002 ER PT J AU Leiner, B AF Leiner, Barbara TI The Legacy of War: An Intergenerational Perspective SO SMITH COLLEGE STUDIES IN SOCIAL WORK LA English DT Article DE Veterans; combat trauma; intergenerational effects; family relationships ID CHILDREN; VETERANS; HOLOCAUST; SURVIVORS AB Children of combat veterans are affected to varying extents by the physical and psychological aftermath of war as experienced by the parent. Traumatic experiences exist on a continuum; trauma related messages can be communicated by a parent who does not have Post Traumatic Stress Disorder. An intergenerational perspective explores the complex family processes by which those who did not experience the actual events come to exhibit varying degress of emotional, psychological and behavioral manifestations of their parents' traumatic experiences. C1 Walter Reed Army Med Ctr, Child & Adolescent Psychiat Serv, LCSW C, Washington, DC 20307 USA. RP Leiner, B (reprint author), Walter Reed Army Med Ctr, Child & Adolescent Psychiat Serv, LCSW C, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM BARBARA.LEINER@US.ARMY.MIL NR 16 TC 2 Z9 2 U1 0 U2 4 PU HAWORTH PRESS INC PI BINGHAMTON PA 10 ALICE ST, BINGHAMTON, NY 13904-1580 USA SN 0037-7317 J9 SMITH COLL STUD SOC JI Smith Coll. Stud. Soc. Work PY 2009 VL 79 IS 3-4 BP 375 EP 391 AR PII 916163815 DI 10.1080/00377310903249884 PG 17 WC Social Work SC Social Work GA 524IL UT WOS:000272136900013 ER PT J AU Grace, JK Yamamoto, RT AF Grace, J. Kenneth Yamamoto, Robin T. TI Food Utilization and Fecal Pellet Production by Drywood Termites (Isoptera: Kalotermitidae) SO SOCIOBIOLOGY LA English DT Article ID CRYPTOTERMES-BREVIS ISOPTERA AB Cryptotermes brevis (Walker) and Incisitermes immigrans (Light) nymphs were held either individually or in groups of ten for an eight-week period, and fed either filter paper, Douglas-fir, or Ponderosapine. Total consumption was noted; and fecal pellet number, mass, and volume were recorded weekly. Solitary individuals defecated more and produced smaller fecal pellets than nymphs maintained in groups, although the total individual mass of feces produced was similar. Diet affected feeding, food utilization, and fecal pellet number and mass. Consumption and defecation reflected cellulose and lignin content of the substrate, with less ingestion of filter paper than wood on a weight basis, but greater utilization of the ingested paper (98%) and less fecal mass. The percentages of the ingested wood utilized (not excreted) were virtually equivalent for Douglas-fir and pine: 63% and 65%, respectively, with C. brevis, and 71% and 72% with I. immigrans. Each I. immigrans nymph consumed about 0.2 mg of wood each day, while each C. brevis nymph consumed slightly less than 0.15 mg of wood per day. On the average, nymphs of both termite species deposited from 0.7 to 1.0 fecal pellets per day, equivalent to a daily average fecal mass of 0.06 mg when fed Douglas-fir, and 0.05 mg when fed pine. Correlation of these data with population growth curves could permit estimation of the size and age of drywood termite colonies. C1 [Grace, J. Kenneth] Univ Hawaii Manoa, Dept Plant & Environm Protect Sci, Honolulu, HI 96822 USA. [Yamamoto, Robin T.] US Army Garrison Hawaii, Environm Div, Directorate Publ Works, Schofield Barracks, HI 96857 USA. RP Grace, JK (reprint author), Univ Hawaii Manoa, Dept Plant & Environm Protect Sci, 3050 Maile Way, Honolulu, HI 96822 USA. EM kennethg@hawaii.edu; robin.yamamoto@us.army.mil FU USDA-ARS Specific Cooperative Agreement [58-6615-4-237]; College of Tropical Agriculture and Human Resources, University of Hawaii at Mano FX This research was supported by USDA-ARS Specific Cooperative Agreement 58-6615-4-237, and McIntire-Stennis funds for forestry research administered by the College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa. NR 10 TC 4 Z9 4 U1 1 U2 2 PU CALIFORNIA STATE UNIV PI CHICO PA DEPT BIOL SCI, CHICO, CA 95929 USA SN 0361-6525 J9 SOCIOBIOLOGY JI Sociobiology PY 2009 VL 53 IS 3 BP 903 EP 911 PG 9 WC Entomology SC Entomology GA 507NI UT WOS:000270860800022 ER PT J AU Clausen, J Korte, N AF Clausen, Jay Korte, Nic TI The Distribution of Metals in Soils and Pore Water at Three US Military Training Facilities SO SOIL & SEDIMENT CONTAMINATION LA English DT Article DE antimony; copper; lead; pore-water sampling; soil contamination; zinc ID SHOOTING RANGE SOIL; TRACE-METALS; LEAD SHOT; SPECIATION; CONTAMINATION; SPECTROSCOPY; BULLETS AB Small arms firing ranges at military training facilities can have enormous heavy metal burdens (percent level) in soils. Currently there are few published works that quantify the metal content of soils and waters at military installations or speculate on the potential for migration of these contaminants into groundwater. This article documents metals in soils and waters at nine small arms training ranges at three military installations in the U. S. Soil samples were collected from the surface and shallow subsurface. The results demonstrated that lead, antimony, copper, and zinc were the principal contaminants of interest and mapping a site's lead and copper surface distributions would adequately define the extent of impacted soil. Lower metal concentrations at three of the ranges reflected previous remediation by means of physical separation and mechanical removal of metallic fragments followed by fixation treatment with Maectite (TM). Except for the treated ranges where mixing had occurred, subsurface soil samples indicated limited vertical migration. Several of the ranges were also monitored for trace element migration in the vadose zone by means of suction-cup lysimeters. This pore-water sampling indicated ceramic suction-cup lysimeters are useful for assessing relative concentrations but require care in evaluation because of potential sorption losses. Monitoring of soil water at ranges should include antimony and zinc; the former because, in contrast to the other metals, it is typically soluble in an anionic form, and the latter because of its greater solubility and mobility. C1 [Clausen, Jay] ERDC CRREL, Hanover, NH 03755 USA. RP Clausen, J (reprint author), ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM Jay.L.Clausen@erdc.usace.army.mil NR 34 TC 21 Z9 22 U1 1 U2 18 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1532-0383 J9 SOIL SEDIMENT CONTAM JI Soil. Sediment. Contam. PY 2009 VL 18 IS 5 BP 546 EP 563 DI 10.1080/15320380903085683 PG 18 WC Environmental Sciences SC Environmental Sciences & Ecology GA 495XJ UT WOS:000269928600002 ER PT J AU Lehman, RA Helgeson, MD Keeler, KA Bunmaprasert, T Riew, KD AF Lehman, Ronald A., Jr. Helgeson, Melvin D. Keeler, Kathryn A. Bunmaprasert, Torphong Riew, K Daniel TI Comparison of Magnetic Resonance Imaging and Computed Tomography in Predicting Facet Arthrosis in the Cervical Spine SO SPINE LA English DT Article DE cervical disc arthroplasty; disc replacement; facet joint anklyosis; cervical spine imaging; MRI ID CT MYELOGRAPHY; OSTEOARTHRITIS; JOINTS; MR AB Study Design. Retrospective review. Objective. To determine the ability of magnetic resonance imaging (MRI) and computed tomography (CT) to predict the presence of cervical facet arthrosis. Summary of Background Data. In the Food and Drug Administration Investigational Device Exemption trials of cervical disc arthroplasty (CDA), the presence of facet arthrosis on CT was a contraindication to the insertion of a CDA. Most surgeons routinely obtain an MRI, but not necessarily a CT before performing surgery in the cervical spine. We sought to determine if the MRI alone is adequate to assess for the presence of facet arthrosis. Methods. Three experienced spine surgeons retrospectively evaluated CT scans and MRIs of the same patients, obtained within 30 days of each other in a blinded, random fashion. Reviewers graded each of the MRI and CT scan as normal or abnormal on 3 separate occasions and if the facet was abnormal, each reviewer graded the degree of arthrosis. The radiologist's evaluation for each study was compared with our results. Results. Of 594 facets analyzed, 43.1% were categorized as normal on CT, and of those, MRI concordance was only 63.7% with moderate/substantial intermethod agreement. Furthermore, MRI was concordant only 15.9% of the time in patients with ankylosed facet joints on CT. CT inter-rater reliability showed substantial agreement for diagnoses of both normal and ankylosis and fair agreement for lesser degrees of facet arthrosis. MRI inter-rater reliability showed fair/moderate agreement in normal and ankylosed segments and only slight agreement with lesser degrees of facet arthrosis. CT intrarater reliability showed substantial agreement in normal or ankylosed joints, but only fair agreement for all other categories; MRI showed only fair agreement. Conclusion. The ability of MRI to adequately determine the presence or amount of facet arthrosis is not reliable. Additionally, for abnormal facets, MRI was not reliable in adequately determining the degree of arthrosis. Our data suggest that computed tomography remains necessary in diagnosing facet arthrosis before CDA. C1 [Lehman, Ronald A., Jr.; Helgeson, Melvin D.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Keeler, Kathryn A.; Riew, K Daniel] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA. [Bunmaprasert, Torphong] Chiang Mai Univ, Dept Orthopaed, Fac Med, Chiang Mai, Thailand. RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. EM armyspine@yahoo.com NR 10 TC 10 Z9 10 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD JAN 1 PY 2009 VL 34 IS 1 BP 65 EP 68 DI 10.1097/BRS.0b013e3181919526 PG 4 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 405YV UT WOS:000263261000011 PM 19127162 ER PT S AU LeSueur, KG Jovanov, E AF LeSueur, Kenneth G. Jovanov, Emil GP IEEE TI Performance Analysis of the Augmented Wireless Sensor Network Testbed SO SSST: 2009 41ST SOUTHEASTERN SYMPOSIUM ON SYSTEM THEORY SE Southeastern Symposium on System Theory LA English DT Proceedings Paper CT 41st Southeastern Symposium on System Theory CY MAR 15-17, 2009 CL Tullahoma, TN DE Modeling & Simulation; Wireless Systems; Network & Communications AB Existing testing systems are not suited for testing of tactical hardware in complex battlefield configurations due to the increased complexity of sensors that include network interfaces and sensor fusion algorithms. We are developing a system for augmented testing of wireless sensor networks that supports virtual system configurations interacting with the real-time hardware in the loop. The testbed provides a realistic simulated representation of a tactical network that allows faithful testing of networked systems focusing on hardware in the loop sensors and sensor fusion systems. Systems can be tested using this method in a controlled repeatable environment not feasible in field testing. The system design combines dedicated High Performance Computing (HPC) resources with a scalable, high fidelity network emulation and a Computer Generated Forces (CGF) model to virtually represent the tactical network, force movement, interactions, and communication loads to systems under test. The system is implemented using QualNet network emulation and OneSAF CGF running on a parallel Linux blade system and integrates sensors to the simulated virtual environment through wireless gateways and Ethernet connections. This paper presents the design framework, current implementation of the system, and real-time performance measurements. C1 [LeSueur, Kenneth G.] USA, Redstone Tech Test Ctr, Subsyst Test & Anal Branch, Redstone Arsenal, AL 35898 USA. [Jovanov, Emil] Univ Alabama, Dept Elect & Comp Engn, Huntsville, AL 35899 USA. RP LeSueur, KG (reprint author), USA, Redstone Tech Test Ctr, Subsyst Test & Anal Branch, Redstone Arsenal, AL 35898 USA. EM Ken.lesueur@us.army.mil; jovanov@ece.uah.edu OI Jovanov, Emil/0000-0001-6754-3518 NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0094-2898 BN 978-1-4244-3324-7 J9 SE SYM SYS THRY PY 2009 BP 319 EP + DI 10.1109/SSST.2009.4806836 PG 2 WC Computer Science, Artificial Intelligence; Computer Science, Hardware & Architecture; Computer Science, Theory & Methods; Robotics SC Computer Science; Robotics GA BKN37 UT WOS:000268672400064 ER PT J AU Hromadka, T Whitley, R Horton, S Smith, M Lindquist, J AF Hromadka, T. V., II Whitley, R. J. Horton, S. B. Smith, M. J. Lindquist, J. M. TI Generous statistical tests SO STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT LA English DT Article DE Testing unlikely events; Extreme deviations; PCB contamination AB A common statistical problem is deciding which of two possible sources, A and B, of a contaminant is most likely the actual source. The situation considered here, based on an actual problem of polychlorinated biphenyl contamination discussed below, is one in which the data strongly supports the hypothesis that source A is responsible. The problem approach here is twofold: One, accurately estimating this extreme probability. Two, since the statistics involved will be used in a legal setting, estimating the extreme probability in such a way as to be as generous as is possible toward the defendant's claim that the other site B could be responsible; thereby leaving little room for argument when this assertion is shown to be highly unlikely. The statistical testing for this problem is modeled by random variables {X (i) } and the corresponding sample mean for a given number a (0). Under the hypothesis that the random variables {X (i) } satisfy E(X (i) ) mu, for some 0 < mu < 1, statistical tests are given, described as "generous", because is maximized. The intent is to be able to reject the hypothesis that a (0) is a value of the sample mean while eliminating any possible objections to the model distributions chosen for the {X (i) } by choosing those distributions which maximize the value of for the test used. C1 [Hromadka, T. V., II; Horton, S. B.; Smith, M. J.; Lindquist, J. M.] US Mil Acad, Dept Math Sci, West Point, NY 10096 USA. RP Whitley, R (reprint author), POB 11133, Bainbridge Isl, WA 98110 USA. EM ted@phdphdphd.com; rwhitley@math.uci.edu; steve.horton@usma.edu; Mick.Smith@usma.edu; aj0558@usma.edu NR 5 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1436-3240 J9 STOCH ENV RES RISK A JI Stoch. Environ. Res. Risk Assess. PD JAN PY 2009 VL 23 IS 1 BP 9 EP 12 DI 10.1007/s00477-007-0190-6 PG 4 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences; Statistics & Probability; Water Resources SC Engineering; Environmental Sciences & Ecology; Mathematics; Water Resources GA 371UR UT WOS:000260857400002 ER PT B AU Macik-Frey, M Quick, JC Shinoda, P Mack, DA Gray, DA Keller, N Cooper, CL AF Macik-Frey, Marilyn Quick, James Campbell Shinoda, Phillip Mack, David A. Gray, David A. Keller, Nathan Cooper, Cary L. BE Rossi, AM Quick, JC Perrewe, PL TI LEADERSHIP FROM A POSITIVE HEALTH PERSPECTIVE A Qualitative Study SO STRESS AND QUALITY OF WORKING LIFE: THE POSITIVE AND THE NEGATIVE SE Stress and Quality of Working Life Series LA English DT Article; Book Chapter ID BEHAVIOR; STRESS; WORK C1 [Macik-Frey, Marilyn] Nicholls State Univ, Thibodaux, LA 70310 USA. [Quick, James Campbell] Univ Texas Arlington, Arlington, TX 76019 USA. [Quick, James Campbell; Cooper, Cary L.] Univ Lancaster, Sch Management, Lancaster LA1 4YW, England. [Mack, David A.] Univ Texas Arlington, Goolsby Leadership Acad, Coll Business, Arlington, TX 76019 USA. [Keller, Nathan] USA, Mental Hlth Cavalry Div 1, Washington, DC USA. RP Macik-Frey, M (reprint author), Nicholls State Univ, Thibodaux, LA 70310 USA. NR 40 TC 1 Z9 1 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-058-0 J9 STRESS QUAL WORK LIF PY 2009 BP 95 EP 121 PG 27 WC Psychology, Applied; Management SC Psychology; Business & Economics GA BKM47 UT WOS:000268494300006 ER PT J AU Helfstein, S Meese, MJ Rassler, D Sawyer, R Schnack, T Sheiffer, M Silverstone, S Taylor, S AF Helfstein, Scott Meese, Michael J. Rassler, Don Sawyer, Reid Schnack, Troy Sheiffer, Mathew Silverstone, Scott Taylor, Scott TI White Paper Prepared for The Secretary of Defense Task Force on DoD Nuclear Weapons Management: Tradeoffs and Paradoxes: Terrorism, Deterrence and Nuclear Weapons SO STUDIES IN CONFLICT & TERRORISM LA English DT Review ID SUICIDE TERRORISM; RESOURCES; SANCTIONS; ATTACKS AB This article was written at the request of the Secretary of Defense Task Force on DoD Nuclear Weapons Management. While this analysis suggests that certain types of terrorists can be deterred from certain types of attacks, it is less optimistic about the use of nuclear weapons in a terrorist deterrent strategy. A broad approach to deterrence may be effective against certain types of terrorist groups and attacks, making it crucially important to disaggregate the terrorist threat when setting policy. The article goes on to address two types of terrorist groups with a oglobal reacho that pose a serious threat to the United States: non-state actors driven by doctrines permitting catastrophic attacks and state-sponsored groups capable of carrying out catastrophic attacks. The analysis reveals a number of previously unappreciated tradeoffs and paradoxes associated with the deterrence of terrorists. C1 [Helfstein, Scott; Meese, Michael J.; Rassler, Don; Sawyer, Reid; Schnack, Troy; Sheiffer, Mathew; Silverstone, Scott; Taylor, Scott] US Mil Acad, Dept Social Sci, Combating Terrorism Ctr, West Point, NY 10996 USA. RP Helfstein, S (reprint author), US Mil Acad, Dept Social Sci, Combating Terrorism Ctr, Lincoln Hall, West Point, NY 10996 USA. EM scott.helfstein@usma.edu NR 104 TC 1 Z9 1 U1 0 U2 8 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1057-610X J9 STUD CONFL TERROR JI Stud. Confl. Terror. PY 2009 VL 32 IS 9 BP 776 EP 801 AR PII 914014634 DI 10.1080/10576100903124049 PG 26 WC International Relations; Political Science SC International Relations; Government & Law GA 485DE UT WOS:000269100200002 ER PT J AU Vittori, J Bremer, K Vittori, P AF Vittori, Jodi Bremer, Kristin Vittori, Pasquale TI Islam in Tanzania and Kenya: Ally or Threat in the War on Terror? SO STUDIES IN CONFLICT & TERRORISM LA English DT Article AB This article explores the historical emergence of Islam in East Africa, details the political background of Tanzania and Kenya, the role of Islam in each country, and U.S. foreign policy in the region. The recent U.S. strategy of intelligence-sharing with Kenya, training and military support to both Kenya and Tanzania, and air strikes in Somalia are assessed. In addition to the current military emphasis, the United States should incorporate more osofto options, such as the promotion of democratic governance in these nascent democracies through political assistance in constitutional, judicial, and law-enforcement reform, as well as encouraging greater inclusion of Muslims in the political system. C1 [Vittori, Jodi] USAF, Washington, DC 20330 USA. [Bremer, Kristin] Kutztown State Univ, Dept Polit Sci, Kutztown, PA USA. [Vittori, Pasquale] USA, Washington, DC 20310 USA. RP Vittori, J (reprint author), USAF, Washington, DC 20330 USA. EM jodimat@hotmail.com NR 35 TC 1 Z9 1 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1057-610X J9 STUD CONFL TERROR JI Stud. Confl. Terror. PY 2009 VL 32 IS 12 BP 1075 EP 1099 AR PII 917321509 DI 10.1080/10576100903319805 PG 25 WC International Relations; Political Science SC International Relations; Government & Law GA 528XP UT WOS:000272480600004 ER PT J AU Todd, CS Abed, AMS Scott, PT Safi, N Earhart, KC Strathdee, SA AF Todd, Catherine S. Abed, Abdullah M. S. Scott, Paul T. Safi, Naqibullah Earhart, Kenneth C. Strathdee, Steffanie A. TI A Cross-Sectional Assessment of Utilization of Addiction Treatment among Injection Drug Users in Kabul, Afghanistan SO SUBSTANCE USE & MISUSE LA English DT Article DE Afghanistan; detoxification; injecting drug user; addiction treatment; needle exchange program ID METHADONE-MAINTENANCE; COST-EFFECTIVENESS; HARM REDUCTION; HIV; PREVENTION; PREVALENCE; PROGRAMS; COHORT; CHINA; RISK AB The purpose of this study was to describe prior use of detoxification and addiction-treatment programs among injection drug users (IDUs) in Kabul, Afghanistan. From 2005-2006, IDUs (n = 464) recruited into this cross-sectional study completed an interviewer-administered questionnaire and whole blood rapid testing with fingerstick samples for HIV, syphilis, and hepatitis C antibody and B surface antigen testing. Participants were predominantly male (99.8%), Afghan (98.9%), and had little formal education. Correlates of detoxification and addiction treatment were identified with logistic regression. The majority (94.0%, n = 435) felt great/urgent need for treatment, of whom 56.3% (n = 245) reported inability to access treatment. Prior detoxification was associated with new needle use with each injection (AOR = 1.91, 95% CI: 1.12-3.26) and prior incarceration (AOR = 1.81, 95% CI: 1.04-3.13). The study's limitations are noted. Rapid scale-up and subsidy of needle and syringe programs and opioid agonist treatment is urgently needed in Kabul. C1 [Todd, Catherine S.; Strathdee, Steffanie A.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA. [Abed, Abdullah M. S.; Safi, Naqibullah] Minist Publ Hlth, Natl HIV AIDS Control Program, Kabul, Afghanistan. [Scott, Paul T.] US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD USA. [Earhart, Kenneth C.] USN, Med Res Unit 3, Virol Res Program, Cairo, Egypt. [Todd, Catherine S.] Univ Calif San Diego, Div Int Hlth & Cross Cultural Med, San Diego, CA 92103 USA. [Strathdee, Steffanie A.] Univ Calif San Diego, Sch Med, Dept Family & Prevent Med, Harold Simon Chair, La Jolla, CA 92093 USA. [Strathdee, Steffanie A.] Univ Calif San Diego, Sch Med, Dept Family & Prevent Med, Div Int Hlth & Cross Cultural Med, La Jolla, CA 92093 USA. RP Todd, CS (reprint author), 9500 Gilman Dr,Mailstop 0622, La Jolla, CA 92093 USA. EM cstodd@ucsd.edu RI Strathdee, Steffanie/B-9042-2009 FU FIC NIH HHS [K01TW007408] NR 34 TC 4 Z9 4 U1 0 U2 3 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1082-6084 J9 SUBST USE MISUSE JI Subst. Use Misuse PY 2009 VL 44 IS 3 BP 416 EP 430 AR PII 905008207 DI 10.1080/10826080802347669 PG 15 WC Substance Abuse; Psychiatry; Psychology SC Substance Abuse; Psychiatry; Psychology GA 406JW UT WOS:000263291800008 PM 18979391 ER PT J AU Rotmann, P Tohn, D Wharton, J AF Rotmann, Philipp Tohn, David Wharton, Jaron TI Learning Under Fire: Progress and Dissent in the US Military SO SURVIVAL LA English DT Article AB After initial successes, the US military suffered many painful years in Afghanistan and Iraq before undertaking the most significant retooling of any military while in active combat since the German Army in 1917. The change to a counter-insurgency posture was catalysed by a combination of junior leadership responding to the tactical problems that confronted them and senior institutional dissidents driving deep, controversial changes in doctrine and culture to meet the new requirements. Both components were necessary, but neither was sufficient on its own. They were the product of an institutional culture that strove to be self-learning, with varying levels of success. Specific recommendations recognise, preserve and advance this dynamic in anticipation of future requirements for rapid change in response to the next conflict. C1 [Rotmann, Philipp] Harvard Univ, John F Kennedy Sch Govt, Cambridge, MA 02138 USA. [Tohn, David; Wharton, Jaron] USA, Washington, DC USA. RP Rotmann, P (reprint author), Harvard Univ, John F Kennedy Sch Govt, Cambridge, MA 02138 USA. NR 28 TC 3 Z9 3 U1 0 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0039-6338 J9 SURVIVAL JI Survival PY 2009 VL 51 IS 4 BP 31 EP 48 AR PII 913357015 DI 10.1080/00396330903168824 PG 18 WC International Relations; Political Science SC International Relations; Government & Law GA 552KM UT WOS:000274288700004 ER PT J AU Gentile, GP Rid, T Rotmann, P Tohn, D Wharton, J AF Gentile, Gian P. Rid, Thomas Rotmann, Philipp Tohn, David Wharton, Jaron TI Progress, Dissent and Counter-Insurgency: An Exchange SO SURVIVAL LA English DT Editorial Material AB In the August-September 2009 issue of Survival (vol. 51, no. 4, pp. 31-48), Philipp Rotmann, David Tohn and Jaron Wharton argued that the US military's change to a counterinsurgency posture in the on-going conflicts in Afghanistan and Iraq was catalysed by two products of an institutional culture that strove to be self-learning: the response of junior leadership to tactical problems and senior institutional dissidents driving deep, controversial changes in doctrine and culture. In this Survival Exchange two experts offer US and European perspectives on the authors' argument and recommendations to preserve and advance this dynamic in anticipation of future requirements for rapid change. A response from Rotmann, Tohn and Wharton concludes the debate. C1 [Rotmann, Philipp] Harvard Univ, John F Kennedy Sch Govt, Cambridge, MA 02138 USA. [Tohn, David; Wharton, Jaron] USA, Washington, DC USA. RI Popova, Olga/A-8099-2012 NR 20 TC 2 Z9 2 U1 0 U2 1 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0039-6338 J9 SURVIVAL JI Survival PY 2009 VL 51 IS 6 BP 189 EP + AR PII 917062983 DI 10.1080/00396330903461724 PG 16 WC International Relations; Political Science SC International Relations; Government & Law GA 552KO UT WOS:000274288900012 ER PT S AU Thodos, WT Mathur, NG Lin, CF AF Thodos, William T. Mathur, Navin G. Lin, Ching-Fang BE Trommer, GF TI Modeling, Design, Analysis, Simulation, and Evaluation (MDASE) for Far-Target Location (FTL) Systems SO SYMPOSIUM GYRO TECHNOLOGY 2009 SE SYMPOSIUM GYRO TECHNOLOGY LA English DT Proceedings Paper CT Symposium Gyro Technology 2009 CY SEP 22-23, 2009 CL Karlsruhe, GERMANY SP Univ Karlsruhe, Inst Syst Optimizat, German Inst Navigat AB This paper describes aspects of Modeling, Design, Analysis, Simulation, and Evaluation (MDASE) in relation to gyrocompassing for Far-Target Location (FTL) systems. FTL systems provide an extensive support for many joint operations efforts, which are critical for a variety of defense users. The basic principle of gyrocompassing is to establish azimuth based on the measurement of the earth's angular velocity vector and the local gravity force vector. The US Army needs a suite of effective Modeling, Analysis, Simulation, and Evaluation tools for the design, development, implementation and validation of the gyrocompass based azimuth and attitude determination modules for the FTL systems. C1 [Thodos, William T.] USA, Component Technol Branch, RDECOM, CERDEC,Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP Thodos, WT (reprint author), USA, Component Technol Branch, RDECOM, CERDEC,Night Vis & Elect Sensors Directorate, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU UNIV STUTTGART INST A FUR MECHANIK PI 70550 STUTTGART PA PFAFFENWALDRING 9, 70550 STUTTGART, GERMANY SN 1439-4502 J9 SYMPOSIUM GYRO TECHN PY 2009 PG 10 WC Automation & Control Systems; Engineering, Electrical & Electronic; Instruments & Instrumentation SC Automation & Control Systems; Engineering; Instruments & Instrumentation GA BSM38 UT WOS:000284917000020 ER PT J AU Duddu, R Dave, PR Damavarapu, R Surapaneni, R Parrish, D AF Duddu, Raja Dave, Paritosh R. Damavarapu, Reddy Surapaneni, Rao Parrish, Damon TI Nucleophilic Substitution Reactions of 1-Methyl-2,4,5-trinitroimidazole (MTNI) SO SYNTHETIC COMMUNICATIONS LA English DT Article DE Aminoimidazoles; azido compounds; nitroimidazoles; triazole ID ENERGETIC MATERIALS; DERIVATIVES AB Nucleophilic substitution reactions on 1-methyl-2,4,5-trinitroimidazole (MTNI) are described. C1 [Duddu, Raja; Dave, Paritosh R.] USA, SAIC, ARDEC, Picatinny Arsenal, NJ 07806 USA. [Parrish, Damon] USN, Res Lab, Struct Matter Lab, Washington, DC 20375 USA. RP Duddu, R (reprint author), USA, SAIC, ARDEC, Bldg 3028, Picatinny Arsenal, NJ 07806 USA. EM raja.duddu@us.army.mil NR 18 TC 15 Z9 19 U1 2 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0039-7911 J9 SYNTHETIC COMMUN JI Synth. Commun. PY 2009 VL 39 IS 23 BP 4282 EP 4288 AR PII 916369132 DI 10.1080/00397910902898635 PG 7 WC Chemistry, Organic SC Chemistry GA 525HY UT WOS:000272207100013 ER PT J AU Salerno, SM Arnett, MV Domanski, JP AF Salerno, Stephen M. Arnett, Michael V. Domanski, Jeremy P. TI Standardized Sign-Out Reduces Intern Perception of Medical Errors on the General Internal Medicine Ward SO TEACHING AND LEARNING IN MEDICINE LA English DT Article ID PATIENT-CARE; COMMUNICATION; SUGGESTIONS; SAFETY; SYSTEM; IMPACT AB Background: Prior research on reducing variation in housestaff handoff procedures have depended on proprietary checkout software. Use of low-technology standardization techniques has not been widely studied. Purpose: We wished to determine if standardizing the process of intern sign-out using low-technology sign-out tools could reduce perception of errors and missing handoff data. Methods: We conducted a pre-post prospective study of a cohort of 34 interns on a general internal medicine ward. Night interns coming off duty and day interns reassuming care were surveyed on their perception of erroneous sign-out data, mistakes made by the night intern overnight, and occurrences unanticipated by sign-out. Trainee satisfaction with the sign-out process was assessed with a 5-point Likert survey. Results: There were 399 intern surveys performed 8 weeks before and 6 weeks after the introduction of a standardized sign-out form. The response rate was 95% for the night interns and 70% for the interns reassuming care in the morning. After the standardized form was introduced, night interns were significantly (p .003) less likely to detect missing sign-out data including missing important diseases, contingency plans, or medications. Standardized sign-out did not significantly alter the frequency of dropped tasks or missed lab and X-ray data as perceived by the night intern. However, the day teams thought there were significantly less perceived errors on the part of the night intern (p = .001) after introduction of the standardized sign-out sheet. There was no difference in mean Likert scores of resident satisfaction with sign-out before and after the intervention. Conclusion: Standardized written sign-out sheets significantly improve the completeness and effectiveness of handoffs between night and day interns. Further research is needed to determine if these process improvements are related to better patient outcomes. C1 [Salerno, Stephen M.; Arnett, Michael V.; Domanski, Jeremy P.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. RP Salerno, SM (reprint author), Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. EM stephen.salerno@us.army.mil NR 16 TC 28 Z9 28 U1 0 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1040-1334 J9 TEACH LEARN MED JI Teach. Learn. Med. PY 2009 VL 21 IS 2 BP 121 EP 126 AR PII 909979899 DI 10.1080/10401330902791354 PG 6 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA 425OG UT WOS:000264646400008 PM 19330690 ER PT J AU Goodwin, GF Burke, CS Wildman, JL Salas, E AF Goodwin, Gerald F. Burke, C. Shawn Wildman, Jessica L. Salas, Eduardo BE Salas, E Goodwin, GF Burke, CS TI Team Effectiveness in Complex Organizations: An Overview SO TEAM EFFECTIVENESS IN COMPLEX ORGANIZATIONS: CROSS-DISCIPLINARY PERSPECTIVES AND APPROACHES SE SIOP Organizational Frontiers Series LA English DT Article; Book Chapter ID WORK TEAMS; TRAINING WORK; MODEL; EXTENSION; BEHAVIOR; TIME C1 [Goodwin, Gerald F.] USA, Res Inst Behav & Social Sci, Washington, DC USA. [Salas, Eduardo] Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, Orlando, FL 32816 USA. [Wildman, Jessica L.] Univ Cent Florida, Ind & Org Psychol Program, Orlando, FL 32816 USA. [Wildman, Jessica L.] USA, Res Lab, Washington, DC USA. [Salas, Eduardo] Amer Psychol Assoc, New York, NY USA. RP Goodwin, GF (reprint author), USA, Res Inst Behav & Social Sci, Washington, DC USA. NR 47 TC 5 Z9 6 U1 0 U2 3 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH ROAD, HOVE BN3 2FA, E SUSSEX, ENGLAND BN 978-0-8058-5881-5 J9 SIOP ORGAN FRONT SER PY 2009 BP 3 EP 16 PG 14 WC Psychology, Applied; Management SC Psychology; Business & Economics GA BUY94 UT WOS:000290753500003 ER PT J AU Salas, E Goodwin, GF Burke, CS AF Salas, Eduardo Goodwin, Gerald F. Burke, C. Shawn BE Salas, E Goodwin, GF Burke, CS TI Team Effectiveness in Complex Organizations Cross-Disciplinary Perspectives and Approaches Preface SO TEAM EFFECTIVENESS IN COMPLEX ORGANIZATIONS: CROSS-DISCIPLINARY PERSPECTIVES AND APPROACHES SE SIOP Organizational Frontiers Series LA English DT Editorial Material; Book Chapter C1 [Salas, Eduardo] Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, Orlando, FL 32816 USA. [Goodwin, Gerald F.] USA, Res Inst, Washington, DC USA. [Goodwin, Gerald F.] USA, Res Inst Behav & Social Sci, Washington, DC USA. [Salas, Eduardo] Amer Psychol Assoc, New York, NY USA. RP Salas, E (reprint author), Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, Orlando, FL 32816 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH ROAD, HOVE BN3 2FA, E SUSSEX, ENGLAND BN 978-0-8058-5881-5 J9 SIOP ORGAN FRONT SER PY 2009 BP XV EP XVI PG 2 WC Psychology, Applied; Management SC Psychology; Business & Economics GA BUY94 UT WOS:000290753500002 ER PT J AU Salas, E Rosen, MA Burke, CS Goodwin, GF AF Salas, Eduardo Rosen, Michael A. Burke, C. Shawn Goodwin, Gerald F. BE Salas, E Goodwin, GF Burke, CS TI The Wisdom of Collectives in Organizations: An Update of the Teamwork Competencies SO TEAM EFFECTIVENESS IN COMPLEX ORGANIZATIONS: CROSS-DISCIPLINARY PERSPECTIVES AND APPROACHES SE SIOP Organizational Frontiers Series LA English DT Article; Book Chapter ID SHARED MENTAL MODELS; RELATIONSHIP CONFLICT; SITUATION AWARENESS; WORK TEAMS; TRANSACTIVE MEMORY; COGNITIVE-ABILITY; GROUP-PERFORMANCE; MANAGEMENT TEAMS; DECISION-MAKING; TASK C1 [Salas, Eduardo] Univ Cent Florida, Human Syst Integrat Res Dept, Inst Simulat & Training, Orlando, FL 32816 USA. [Salas, Eduardo] UCF, Appl Expt & Human Factors Ph D Program, Orlando, FL USA. [Salas, Eduardo] NAWC TSD, Training Technol Dev Branch, Orlando, FL USA. [Salas, Eduardo] Amer Psychol Assoc, Washington, DC USA. [Salas, Eduardo] Human Factors & Ergon Soc, Santa Monica, CA USA. [Rosen, Michael A.] Univ Cent Florida, Appl Expt & Human Factors Psychol Program, Orlando, FL 32816 USA. [Goodwin, Gerald F.] USA, Res Inst Behav & Social Sci, Washington, DC USA. [Goodwin, Gerald F.] Dept Def, Washington, DC USA. [Goodwin, Gerald F.] Amer Inst Res, Washington, DC USA. RP Salas, E (reprint author), Univ Cent Florida, Human Syst Integrat Res Dept, Inst Simulat & Training, Orlando, FL 32816 USA. NR 157 TC 42 Z9 44 U1 1 U2 4 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH ROAD, HOVE BN3 2FA, E SUSSEX, ENGLAND BN 978-0-8058-5881-5 J9 SIOP ORGAN FRONT SER PY 2009 BP 39 EP 79 PG 41 WC Psychology, Applied; Management SC Psychology; Business & Economics GA BUY94 UT WOS:000290753500005 ER PT J AU DeChurch, LA Mathieu, JE AF DeChurch, Leslie A. Mathieu, John E. BE Salas, E Goodwin, GF Burke, CS TI Thinking in Terms of Multiteam Systems SO TEAM EFFECTIVENESS IN COMPLEX ORGANIZATIONS: CROSS-DISCIPLINARY PERSPECTIVES AND APPROACHES SE SIOP Organizational Frontiers Series LA English DT Article; Book Chapter ID TEAM EFFECTIVENESS; WORK TEAMS; EMPOWERMENT; TASK; INTERDEPENDENCE; PERFORMANCE; ANTECEDENTS; MODEL; DIMENSIONS; MANAGEMENT C1 [DeChurch, Leslie A.] Univ Cent Florida, DELTA Res Lab, Orlando, FL 32816 USA. [DeChurch, Leslie A.] USA, Res Inst Behav & Social Sci, Washington, DC USA. [Mathieu, John E.] Univ Connecticut, Storrs, CT 06269 USA. [Mathieu, John E.] Amer Psychol Assoc, New York, NY USA. RP DeChurch, LA (reprint author), Univ Cent Florida, DELTA Res Lab, Orlando, FL 32816 USA. NR 50 TC 12 Z9 12 U1 2 U2 7 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH ROAD, HOVE BN3 2FA, E SUSSEX, ENGLAND BN 978-0-8058-5881-5 J9 SIOP ORGAN FRONT SER PY 2009 BP 267 EP 292 PG 26 WC Psychology, Applied; Management SC Psychology; Business & Economics GA BUY94 UT WOS:000290753500012 ER PT J AU Essens, PJMD Vogelaar, ALW Mylle, JJC Blendell, C Paris, C Halpin, SM Baranski, JV AF Essens, Peter J. M. D. Vogelaar, Ad L. W. Mylle, Jacques J. C. Blendell, Carol Paris, Carol Halpin, Stanley M. Baranski, Joseph V. BE Salas, E Goodwin, GF Burke, CS TI Team Effectiveness in Complex Settings: A Framework SO TEAM EFFECTIVENESS IN COMPLEX ORGANIZATIONS: CROSS-DISCIPLINARY PERSPECTIVES AND APPROACHES SE SIOP Organizational Frontiers Series LA English DT Article; Book Chapter ID PERSON-ENVIRONMENT FIT; LEADERSHIP; PERFORMANCE; ORGANIZATIONS C1 [Mylle, Jacques J. C.] Royal Mil Acad, Dept Psychol, Brussels, Belgium. [Halpin, Stanley M.] Kansas State Univ, Grad Sch, Manhattan, KS 66506 USA. [Halpin, Stanley M.] USA, Res Inst, Res Grp, Ft Leavenworth, KS USA. [Baranski, Joseph V.] Def Res & Dev Canada, Collaborat Performance & Learning Sect, Toronto, ON, Canada. NR 58 TC 9 Z9 10 U1 0 U2 0 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH ROAD, HOVE BN3 2FA, E SUSSEX, ENGLAND BN 978-0-8058-5881-5 J9 SIOP ORGAN FRONT SER PY 2009 BP 293 EP 320 PG 28 WC Psychology, Applied; Management SC Psychology; Business & Economics GA BUY94 UT WOS:000290753500013 ER PT J AU Salas, E Wildman, JL AF Salas, Eduardo Wildman, Jessica L. BE Salas, E Goodwin, GF Burke, CS TI Ten Critical Research Questions: The Need for New and Deeper Explorations SO TEAM EFFECTIVENESS IN COMPLEX ORGANIZATIONS: CROSS-DISCIPLINARY PERSPECTIVES AND APPROACHES SE SIOP Organizational Frontiers Series LA English DT Article; Book Chapter ID TEAM MENTAL MODELS; TRANSACTIVE MEMORY; WORK GROUPS; SOFTWARE-DEVELOPMENT; SITUATION AWARENESS; MULTITEAM SYSTEMS; COGNITIVE-ABILITY; MANAGEMENT TEAMS; PERFORMANCE; KNOWLEDGE C1 [Salas, Eduardo] Univ Cent Florida, Human Syst Integrat Res Dept, Inst Simulat & Training, Orlando, FL 32816 USA. [Salas, Eduardo] UCF, Appl Expt & Human Factors Ph D Program, Orlando, FL USA. [Salas, Eduardo] Amer Psychol Assoc, New York, NY USA. [Wildman, Jessica L.] Univ Cent Florida, Ind & Org Psychol Program, Orlando, FL 32816 USA. [Wildman, Jessica L.] USA, Res Lab, Washington, DC USA. RP Salas, E (reprint author), Univ Cent Florida, Human Syst Integrat Res Dept, Inst Simulat & Training, Orlando, FL 32816 USA. NR 114 TC 4 Z9 5 U1 1 U2 3 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH ROAD, HOVE BN3 2FA, E SUSSEX, ENGLAND BN 978-0-8058-5881-5 J9 SIOP ORGAN FRONT SER PY 2009 BP 525 EP 546 PG 22 WC Psychology, Applied; Management SC Psychology; Business & Economics GA BUY94 UT WOS:000290753500022 ER PT S AU Dwight, LW Jensen, JO AF Woolard, Dwight L. Jensen, James O. BE Linden, KJ Sadwick, LP OSullivan, CMM TI Advanced nanoelectronic architectures for THz-based biological agent detection SO TERAHERTZ TECHNOLOGY AND APPLICATIONS II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Terahertz Technology and Applications II CY JAN 28-29, 2009 CL San Jose, CA SP SPIE DE nanoscale; electronic architectures; terahertz signatures; biological agents; detection AB The U.S. Army Research Office (ARO) and the U.S. Army Edgewood Chemical Biological Center (ECBC) jointly lead and support novel research programs that are advancing the state-of-the-art in nanoelectronic engineering in application areas that have relevance to national defense and security. One fundamental research area that is presently being emphasized by ARO and ECBC is the exploratory investigation of new bio-molecular architectural concepts that can be used to achieve rapid, reagent-less detection and discrimination of biological warfare (BW) agents, through the control of multi-photon and multi-wavelength processes at the nanoscale. This paper will overview an ARO/ECBC led multidisciplinary research program presently under the support of the U.S. Defense Threat Reduction Agency (DTRA) that seeks to develop new devices and nanoelectronic architectures that are effective for extracting THz signatures from target bio-molecules. Here, emphasis will be placed on the new nanosensor concepts and THz/Optical measurement methodologies for spectral-based sequencing/identification of genetic molecules. C1 [Woolard, Dwight L.] USA, Res Off, Durham, NC 27709 USA. RP Dwight, LW (reprint author), USA, Res Off, Durham, NC 27709 USA. EM dwight.woolard@us.army.mil NR 13 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7461-2 J9 PROC SPIE PY 2009 VL 7215 AR 72150K DI 10.1117/12.809127 PG 15 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Optics; Spectroscopy SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Optics; Spectroscopy GA BST70 UT WOS:000285751800015 ER PT B AU Gooch, W Showalter, D Burkins, M Montgomery, J Squillacioti, R Nichols, A Martin, L Bailey, R Swiatek, G AF Gooch, William Showalter, Dwight Burkins, Matthew Montgomery, Jonathan Squillacioti, Richard Nichols, Andrew Martin, Larry Bailey, Ronald Swiatek, Glenn GP TMS TI DEVELOPMENT AND BALLISTIC TESTING OF A NEW CLASS OF AUTO-TEMPERED HIGH HARD STEELS UNDER MILITARY SPECIFICATION MIL-DTL-46100E SO TMS 2009 138TH ANNUAL MEETING & EXHIBITION - SUPPLEMENTAL PROCEEDINGS, VOL 3: GENERAL PAPER SELECTIONS LA English DT Proceedings Paper CT 138th TMS Annual Meeting and Exhibition CY FEB 15-19, 2009 CL San Francisco, CA DE High Hard Steel; MIL-DTL46100E; Auto-tempered; Ballistic Testing; Armor AB The US Army Research Laboratory (ARL) was directed to investigate various ways to expand current steel armor plate production as the large military demand for armor plate exceeded the current production capacity at US steel facilities for quench and tempered high hard armor (HHA) steel plate. The solution was to expand the availability of HHA steels under the current HHA military specification (MIL-DTL-46100) to include a new class of air-quenched, auto-tempered steels that do not use existing water quench and temper facilities. Allegheny Technologies Incorporated (ATI) developed an auto-tempered steel alloy ATI 500-MIL (TM) that has physical and mechanical properties that meet the current HHA specification. ARL procured sufficient amounts of ATI 500-MIL (TM) plate to allow acceptance testing and subsequent certification of ATI 500-MIL (TM) plate as complying with the First Article requirements of the newly revised MIL-DTL-46100E specification. This paper documents the development of ATI 500-MIL (TM) plate and subsequent ballistic testing and inclusion into the specification as Class 2 auto-tempered HHA steel. C1 [Gooch, William; Showalter, Dwight; Burkins, Matthew; Montgomery, Jonathan; Squillacioti, Richard] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gooch, W (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 5 TC 2 Z9 2 U1 1 U2 3 PU MINERALS, METALS & MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086-7514 USA BN 978-0-87339-740-7 PY 2009 BP 321 EP 328 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy GA BJC17 UT WOS:000264675200041 ER PT J AU Woo, S Pham, D Muhin, I Du, N Wintz, H Guan, X PerKins, E Vulpe, C AF Woo, Seonock Pham, Don Muhin, Irma Du, Nick Wintz, Henri Guan, Xin PerKins, Edward Vulpe, Chris TI Screening of Differentially Expressed Genes of Fathead Minnow Exposed to Hexahydro-1,3,5-Trinitro-1,3,5-Triazine Using Microarray SO TOXICOLOGIC PATHOLOGY LA English DT Meeting Abstract C1 [Woo, Seonock; Pham, Don; Muhin, Irma; Du, Nick; Wintz, Henri; Vulpe, Chris] UC Berkeley, Berkeley, CA USA. [Guan, Xin; PerKins, Edward] USA, Corps Engineer Res & Dev Ctr, Vicksburg, MS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0192-6233 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD JAN PY 2009 VL 37 IS 1 MA P69 BP 144 EP 144 PG 1 WC Pathology; Toxicology SC Pathology; Toxicology GA 463XE UT WOS:000267466500082 ER PT J AU Brimfield, AA Mancebo, AM Mason, RP Jiang, JJ Siraki, AG Novak, MJ AF Brimfield, A. A. Mancebo, A. M. Mason, R. P. Jiang, J. J. Siraki, A. G. Novak, M. J. TI Free radical production from the interaction of 2-chloroethyl vesicants (mustard gas) with pyridine nucleotide-driven flavoprotein electron transport systems SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Chemical warfare; Flavoenzyme; Chloroethyl mustards; Onium ion; Enzymatic reduction; Electron transport; Free radical; EPR ID NITRIC-OXIDE SYNTHASE; SULFUR MUSTARD; THIOREDOXIN REDUCTASE; SULFONIUM SALTS; IN-VITRO; MECHANISM; TOXICITY; DRUG; IDENTIFICATION; PROCARBAZINE AB The biochemical sequelae to chloroethyl mustard exposure correspond very well to toxic processes initiated by free radicals. Additionally, mustard solutions contain spontaneously formed cyclic onium ions which produce carbon free radicals when reduced electrochemically. Therefore, we hypothesized that the onium ions of sulfur or nitrogen mustards might produce carbon free radicals upon being reduced enzymatically, and that these radicals might constitute a metabolic activation. We set out to document radical production using an in vitro metabolic system and electron paramagnetic resonance (EPR). Our system consisted of NADPH, one of several pyridine nucleotide-driven flavoprotein reductases, cytochrome c as a terminal electron acceptor, various sulfur or nitrogen mustards and the spin trap alpha-[4-pyridyl-1-oxide]-N-tertbutylnitrone in buffer. Reactions were started by adding the reductase to the other materials, vortexing and immediately transferring the mixture to a 10 mm EPR flat cell. Repeated scans on a Bruker ESP 300E EPR spectrometer produced a triplet of doublets with hyperfine splitting constants of a(N) = 15.483 G and a(H)=2.512 G. The outcome supported our hypothesis that carbon-centered free radicals are produced when mustard-related onium ions are enzymatically reduced. The EPR results varied little with the chloroethyl compound used or with porcine or human cytochrome P450 reductase, the reductase domain of rat brain neuronal nitric oxide synthase or rat liver thioredoxin reductase. Our results offer new insight into the basis for mustard-induced vesication and the outcome of exposure to different mustards. The free radical model provides an explanation for similarities in the lesions arising from mustard exposure and energy-based lesions such as those from heat, ultraviolet and nuclear radiation as well as damage across tissue types such as skin, eyes or airway epithelium. Published by Elsevier Inc. C1 [Brimfield, A. A.; Mancebo, A. M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Mason, R. P.; Jiang, J. J.; Siraki, A. G.] NIEHS, Lab Pharmacol & Chem, Res Triangle Pk, NC 27709 USA. [Novak, M. J.] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA. RP Brimfield, AA (reprint author), USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. EM alan.a.brimfield@us.army.mil FU Defense Threat Reduction Agency; Joint Science and Technology Office; U.S. Army Medical Research and Materiel Command; Intramural Research Program of the NIH; [17-00-2-008] FX This work was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S and T Division and, in part, by award number DAMD 17-00-2-008 from the U.S. Army Medical Research and Materiel Command. This research was also Supported in part by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences. Thanks are due to Dr. Carmen Arroyo and Mr. Brendon Gallagher of USAMRICD for helping to get this work started. We are grateful to Professor Bettie Sue Masters of the Department of Biochemistry, University of Texas Health Sciences Center, San Antonio, for the kind gift of recombinant rat brain nNOS reductase domain and recombinant porcine liver NADPHcytochrome P450 redUctase and to Dr. Thomas M. Shea of that laboratory for generous advice. And finally, we would like to express our thanks to Dr. MarkA. Zottola and Dr. Sunil D. Soni of USAMRICD for discussions that were inevitably helpful and enlightening. NR 43 TC 16 Z9 17 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X EI 1096-0333 J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD JAN 1 PY 2009 VL 234 IS 1 BP 128 EP 134 DI 10.1016/j.taap.2008.10.002 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 397SL UT WOS:000262682300014 PM 18977373 ER PT J AU Quinn, MJ McFarland, CA Johnson, MS AF Quinn, Michael J., Jr. McFarland, Craig A. Johnson, Mark S. TI Unsuitability of the Northern Bobwhite as a Model Species for the Assessment of Reproductive Behavior in Toxicological Studies SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Avian; reproduction; behavior; toxicology; quail ID JAPANESE-QUAIL; DISRUPTING CHEMICALS; ENDOCRINE; EXPOSURE; TOXICITY AB The northern bobwhite (Colinus virginianus) is used in numerous wildlife toxicity studies, however no published reports could be located that mention the measurement of reproductive behavior in this species. Changes in reproductive behavior can be potentially more sensitive to environmental contaminant exposures and less resilient than more traditional physiological responses. Male bobwhite copulatory behaviors were measured similarly to those that are well established for use in Japanese quail (Coturnix japonica). Time to initiate mating, time to achieve a successful copulation, the number of mating attempts, and the number of successful copulations were recorded daily for four consecutive days over a period of 3 min for each male/female pair of birds per day. When females were introduced to male cages, males were more occupied with shows of aggression towards neighboring males than attempts to mate with the female sharing their space. Only one male successfully mated with a female over the entire 4 days of the test. Future attempts at assessing reproductive behavior in this species may be more successful if birds are separated from the rest of the group when paired. The Japanese quail seems to be a more appropriate species for overall reproductive tests due to: willingness of males to copulate in the presence of other males, consistent egg laying ability, and the short time required for embryonic development and reproductive maturity. C1 [Quinn, Michael J., Jr.; McFarland, Craig A.; Johnson, Mark S.] USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Directorate Toxicol, Aberdeen Proving Ground, MD 21222 USA. RP Quinn, MJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Directorate Toxicol, Edgewood Area,Bldg E-2100, Aberdeen Proving Ground, MD 21222 USA. EM micheal.james.quinn@us.army.mil NR 11 TC 0 Z9 0 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1537-6516 EI 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PY 2009 VL 19 IS 1 BP 40 EP 43 DI 10.1080/15376510802226482 PG 4 WC Toxicology SC Toxicology GA 378CX UT WOS:000261299800005 PM 19778231 ER PT J AU Guarisco, JA O'Donnell, JC Skovira, JW McDonough, JH Shih, TM AF Guarisco, John A. O'Donnell, John C. Skovira, Jacob W. McDonough, John H. Shih, Tsung-Ming TI In vivo oxime administration does not influence Ellman acetylcholinesterase assay results SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Acetylcholinesterase; acetylthiocholine; Ellman assay; in vivo; oxime ID ORGANOPHOSPHORUS NERVE AGENTS; CARBOXYLESTERASE INHIBITION; CHOLINESTERASE ACTIVITY; PRALIDOXIME CHLORIDE; SOMAN TOXICITY; HYDROLYSIS; PLASMA; 2-PAM; INTOXICATION; REACTIVATOR AB Organophosphorus compounds (OPs) are potent inhibitors of acetylcholinesterase (AChE). Treatment for OP poisoning is by administration of atropine sulfate, an oxime, and diazepam. Oximes such as 2-PAM are used to reactivate OP-inhibited AChE so as to restore normal enzymatic function and serve as a true antidote. There are reports of non-enzymatic hydrolysis by oximes of acetylthiocholine in in vitro preparations in the widely used Ellman assay for AChE activity, which may confound the interpretation of AChE activity by producing elevated results. The purpose of this experiment was to determine if there is appreciable interference by therapeutic levels of oximes on the results of the Ellman assay in assessing AChE reactivation by oxime compounds in vivo. When therapeutic doses of oximes (2-PAM, HI-6, MMB-4, or MINA) were administered intramuscularly to guinea pigs and samples collected 60 min later, there was no statistical difference between oxime and saline control groups in measured AChE activity in various tissue samples, including blood. With appropriate dilution of samples prior to spectrophotometric assay, the Ellman assay is an acceptable method to measure in vivo oxime reactivation of inhibited AChE. Inclusion of an oxime control group to insure that this particular type of interference is not causing false readings in the assay is a prudent step. C1 [Shih, Tsung-Ming] USA, Med Res Inst Chem Def, ATTN MCMR CDR P, Pharmacol Branch,Res Div, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), USA, Med Res Inst Chem Def, ATTN MCMR CDR P, Pharmacol Branch,Res Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil FU Defense Threat Reduction AgencyJoint Service and Technology Office, Medical Science and Technology Division FX The opinions or assertions contained herein are the private views of the authors, and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense. NR 42 TC 3 Z9 3 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PY 2009 VL 19 IS 6-7 BP 379 EP 385 DI 10.1080/15376510903234773 PG 7 WC Toxicology SC Toxicology GA 502JW UT WOS:000270456100001 PM 19778238 ER PT J AU Shih, TM Skovira, JW O'Donnell, JC McDonough, JH AF Shih, Tsung -Ming Skovira, Jacob W. O'Donnell, John C. McDonough, John H. TI Evaluation of nine oximes on in vivo reactivation of blood, brain, and tissue cholinesterase activity inhibited by organophosphorus nerve agents at lethal dose SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Acetylcholinesterase; cholinesterase inhibitors; cholinesterase reactivation; cyclosarin; guinea pig; HI-6; HLo7; methoxime; nerve agents; organophosphorus compounds; oximes; pralidoxime; sarin; trimedoxime; VR; VX ID PINACOLYL METHYLPHOSPHONOFLUORIDATE; CRYSTAL-STRUCTURES; PYRIDINIUM OXIMES; ACETYLCHOLINESTERASE; SOMAN; VITRO; HI-6; 2-PAM; HYDROLYSIS; MECHANISM AB The capability of several oximes (HI-6, HLo7, MMB-4, TMB-4, carboxime, ICD 585, ICD 692, ICD 3805, and 2-PAM) to reactivate in vivo AChE inhibited by the nerve agents sarin, cyclosarin, VX, or VR in blood, brain regions, and peripheral tissues in guinea pigs was examined and compared. Animals were injected subcutaneously with 1.0 LD(50) of sarin, cyclosarin, VR, or VX, and treated intramuscularly 5 min later with one of these compounds. Toxic signs and lethality were monitored, and tissue AChE activities were determined at 60 min after nerve agent. The animals exposed to sarin or cyclosarin, alone or with non-oxime treatment, some died within 60 min; however, when treated with an oxime, no animal died. For VR or VX, all animals survived for 60 min after exposure, with or without non-oxime or oxime therapy. These nerve agents caused differential degrees of inhibition: in whole blood sarin = cyclosarin > VR = VX; in brain regions sarin > cyclosarin > VX > VR; and in peripheral tissues sarin > VX > cyclosarin > VR. These oximes exhibited differential potency in reactivating nerve agent-inhibited AChE in various peripheral tissues, but not AChE activity in the brain regions. There was no difference in the AChE reactivating potency between the dichloride and dimethanesulfonate salts of HI-6. AChE inhibited by sarin was the most and cyclosarin the least susceptible to oxime reactivation. Overall, MMB-4 appeared to be, among all oximes tested, the most effective in vivo AChE reactivator against the broadest spectrum of nerve agents. C1 [Shih, Tsung -Ming] USA, Med Res Inst Chem Def, ATTN MCMR CDR P, Pharmacol Branch,Res Div, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), USA, Med Res Inst Chem Def, ATTN MCMR CDR P, Pharmacol Branch,Res Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil FU Defense Threat Reduction Agency-Joint Service and Technology Office, Medical Science and Technology Division FX The authors recognized the excellent technical assistance of Laura Gildner, Megan Lyman, Emily Mason, Maura Pannell, and Tami Rowland. This research was supported by the Defense Threat Reduction Agency-Joint Service and Technology Office, Medical Science and Technology Division. NR 48 TC 25 Z9 28 U1 1 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1537-6524 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PY 2009 VL 19 IS 6-7 BP 386 EP 400 DI 10.1080/15376510903213892 PG 15 WC Toxicology SC Toxicology GA 502JW UT WOS:000270456100002 PM 19778239 ER PT B AU Howell, RA Weerasooriya, T Van Aken, DC AF Howell, R. A. Weerasooriya, T. Van Aken, D. C. GP American Foundry Society TI Tensile, High Strain Rate Compression and Microstructural Evaluation of Lightweight Age Hardenable Cast Fe-30Mn-9Al-XSi-0.9C-0.5Mo Steel SO TRANSACTIONS OF THE AMERICAN FOUNDRY SOCIETY, VOL 117 SE Transactions of the American Foundry Society LA English DT Proceedings Paper CT 113th Metalcasting Congress CY APR 07-10, 2009 CL Las Vegas, NV SP Amer Foundry Soc ID AL-C ALLOYS; PHASE-TRANSFORMATIONS; MECHANICAL-PROPERTIES; AUSTENITIC STEELS; SI AB Age hardenable, castable, and lightweight Fe-Mn-Al-C steels are currently being developed and evaluated for substitution of high strength low alloy steel and to meet MIL-PRF-32269 criteria. Two nominal Fe-30Mn-9Al-0.9C-0.5Mo steels were cast and modified with 1 and 1.4 wt.% silicon. Ageing, tensile, and high strain rate compression testing were performed on solution treated and aged samples of both chemistries. Each alloy was solution treated at 1050 C for 2 hours. Microstructures of the solution treated and aged alloys show primary austenite with less than 8 volume % ferrite. The solution treated hardness of the low silicon steel was 230 BHN and the high silicon alloy was 225 BHN. Specimens were aged at 530 C for up to 60 hours. Peak ageing occurs after 30 hours with a peak hardness of 371 BHN for the 1%o silicon containing alloy and 377 BHN for the high silicon alloy. Tensile strengths of the 30 hour aged specimens were 1065 MPa (154 ksi) and 1080 MPa (156 ksi) for the low and high silicon alloys. High strain rate compression testing was conducted on solution treated and 10 hour aged 1% Si containing alloy. Compressive strength of the 1 wt.% Si alloy exceeded 1,500 MPa (217 ksi) at a strain rate of 3000 s(-1). C1 [Howell, R. A.; Weerasooriya, T.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Howell, RA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. NR 26 TC 11 Z9 11 U1 1 U2 2 PU AMER FOUNDRY SOCIETY, INC PI SCHAUMBURG PA 1695 N PENNY LANE, SCHAUMBURG, IL 60173 USA BN 978-0-87433-340-4 J9 TRAN AMER F PY 2009 VL 117 BP 751 EP 763 PG 13 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA BMA20 UT WOS:000271639500063 ER PT J AU Al-Smadi, YM Russell, K Lee, WT Sodhi, RS AF Al-Smadi, Yahia M. Russell, Kevin Lee, Wen-Tzong Sodhi, Raj S. TI AN EXTENSION OF AN ALGORITHM FOR PLANAR FOUR-BAR PATH GENERATION WITH OPTIMIZATION SO TRANSACTIONS OF THE CANADIAN SOCIETY FOR MECHANICAL ENGINEERING LA English DT Article ID MOTION GENERATION; MECHANISMS; LINKAGES AB This work is an extension of the authors' published work on a planar four-bar motion generation search algorithm with Grashof, transmission angle and linkage perimeter conditions [1]. This latest work considers planar four-bar path generation with a coupler point load, crank static torque, crank transverse deflection and follower buckling in a modified search algorithm. As demonstrated in the example, a conventional methodology used in kinematic path generation has been expanded to consider static loading, elastic deflection and buckling in path. generation. These factors must be considered in mechanical design, but are not the focus in traditional kinematic synthesis. C1 [Al-Smadi, Yahia M.] AECOM Special Struct Grp, New York, NY 10005 USA. [Russell, Kevin] USA, Res Dev & Engn Ctr, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [Lee, Wen-Tzong] Leader Univ, Dept Comp Sci & Applicat, Tainan 70970, Taiwan. [Sodhi, Raj S.] New Jersey Inst Technol, Dept Mech Engn, Newark, NJ 07102 USA. RP Al-Smadi, YM (reprint author), AECOM Special Struct Grp, New York, NY 10005 USA. EM yahia.al-smadi@aecom.com NR 21 TC 2 Z9 2 U1 0 U2 0 PU CSME TRANS. PI MONTREAL PA C/O P J ZSOMBOR-MURRAY, MC GILL UNIV, RM 454 THOMAS WORKMAN ENG BLDG 817 SHERBROOKE ST W, MONTREAL, PQ H3A 2K6, CANADA SN 0315-8977 J9 T CAN SOC MECH ENG JI Trans. Can. Soc. Mech. Eng. PY 2009 VL 33 IS 3 BP 443 EP 458 PG 16 WC Engineering, Mechanical SC Engineering GA 542CJ UT WOS:000273468700007 ER PT J AU Jersey, SR Edwards, L AF Jersey, Sarah R. Edwards, Lulu TI Stiffness-Based Assessment of Pavement Foundation Materials Using Portable Tools SO TRANSPORTATION RESEARCH RECORD LA English DT Article ID DEFLECTOMETER AB Traditional pavement quality assurance has focused on soil density and moisture content. Implementation of new mechanistic design methods calls for measuring the resilient modulus of constructed layers to determine whether it matches the modulus used during the pavement design process. Several tools have been marketed for this purpose in recent years. Eleven soil test beds were constructed at the U.S. Army Engineer Research and Development Center to evaluate three of these tools. The study showed that the tools were simple to use and generally obtained repeatable results, but additional information regarding the true nature of the modulus measured by these tools was required to implement their use. C1 [Jersey, Sarah R.; Edwards, Lulu] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Jersey, SR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM sarah.r.jersey@usace.army.mil NR 16 TC 1 Z9 1 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSP RES RECORD JI Transp. Res. Record PY 2009 IS 2116 BP 26 EP 34 DI 10.3141/2116-04 PG 9 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 536TL UT WOS:000273066600004 ER PT J AU Alexander, DR Gilbert, RB AF Alexander, Don R. Gilbert, Robert B. TI Infrastructure Assessment Decision Making During a Crisis SO TRANSPORTATION RESEARCH RECORD LA English DT Article AB Engineers are being challenged to make critical decisions in response to crisis situations occurring around the globe on a seemingly daily basis. The nature of these crises varies widely and can include military missions as well as humanitarian operations in response to hurricanes, tsunamis, fires, and earthquakes. With thousands of lives hanging in the balance, timely and successful responses to these emergencies often depend on the optimal use of the existing horizontal infrastructure, such as roads, airfields, and railroads, in the affected area. Engineers must provide solutions quickly on the basis of limited data, particularly for unanticipated emergency situations. For military operations, options and alternatives are imperative to the success of a mission. This paper describes an analytical approach to the management of uncertainty because of limited data that provides a solution based on seasonal variability in material strengths, spatial variability in material strengths, and spatial variability in pavement layer thicknesses. An example scenario for an airfield is presented to illustrate techniques for analysis of the structural capacity of pavements of marginal quality and quantification of the uncertainty of the results. C1 [Alexander, Don R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Gilbert, Robert B.] Univ Texas Austin, Dept Civil Engn, Cockrell Sch Engn, Austin, TX 78712 USA. RP Alexander, DR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd CEERD GM R, Vicksburg, MS 39180 USA. EM don.r.alexander@usace.army.mil FU U.S. Army Engineer Research and Development Center (ERDC) FX The authors gratefully acknowledge the support of the U.S. Army Engineer Research and Development Center (ERDC) for providing financial support for collaboration with the University of Texas at Austin. NR 3 TC 0 Z9 0 U1 2 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSP RES RECORD JI Transp. Res. Record PY 2009 IS 2093 BP 93 EP 98 DI 10.3141/2093-11 PG 6 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 527ZE UT WOS:000272409000011 ER PT J AU Tingle, JS Jersey, SR AF Tingle, Jeb S. Jersey, Sarah R. TI Full-Scale Evaluation of Geosynthetic-Reinforced Aggregate Roads SO TRANSPORTATION RESEARCH RECORD LA English DT Article ID UNPAVED ROADS AB A full-scale test section was constructed and trafficked by the US. Army Engineer Research and Development Center to evaluate the performance of geosynthetic reinforced aggregate road sections constructed with marginal base materials over a typical subgrade. Eight instrumented aggregate road sections-including three different aggregate base materials and two different geosynthetics-were constructed. The mechanistic response and permanent surface deformation of each pavement section were monitored at selected intervals during trafficking, and the data were analyzed to determine the benefit of using geotextiles or geogrids to reinforce aggregate roads. The test section's results indicated that the geosynthetics improved the performance of the reinforced pavement sections compared with unreinforced sections for all aggregate base materials. The mechanistic response in terms of surface deflection, deflection at the top of the subgrade, and vertical stress at the top of the subgrade was favorably consistent with the observed permanent deformation of the individual test items. C1 [Tingle, Jeb S.; Jersey, Sarah R.] USA, Engineer Res & Dev Ctr, CEERD GM A, Vicksburg, MS 39180 USA. RP Tingle, JS (reprint author), USA, Engineer Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Jeb.S.Tingle@usace.army.mil FU U.S. Army Engineering Research and Development Center, Waterways Experiment Station; Chief of Engineers FX The experiment described here, unless otherwise noted, was conducted under the Lines-of-Communication program of the U.S. Army Corps of Engineers by the U.S. Army Engineering Research and Development Center, Waterways Experiment Station. Permission was granted by the Chief of Engineers to publish this information. NR 8 TC 3 Z9 3 U1 0 U2 5 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSP RES RECORD JI Transp. Res. Record PY 2009 IS 2116 BP 96 EP 107 DI 10.3141/2116-13 PG 12 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 536TL UT WOS:000273066600013 ER PT J AU Priddy, LP Jersey, SR Freeman, RB AF Priddy, Lucy P. Jersey, Sarah R. Freeman, Reed B. TI Determining Rapid-Setting Material Suitability for Expedient Pavement Repairs Full-Scale Traffic Tests and Laboratory Testing Protocol SO TRANSPORTATION RESEARCH RECORD LA English DT Article AB Numerous commercial off-the-shelf products have become available for small surface repairs in portland cement concrete (PCC) pavements, providing short set times, high early strengths, and good durability to withstand heavy loads. These materials have been used successfully for both small repairs in the transportation industry and industrial applications in which the repair was less than 0.03 m(3) (1 ft(3)). Applying these products for larger-volume repairs while still achieving a traffickable surface within 3 h of pavement repair has been a challenge. Experience gained from testing these products for full-depth repairs provides guidance for repair techniques that will expedite opening airfield or highway pavements to traffic and minimize the frequency of maintenance activities. An investigation conducted at the U.S. Army Engineer Research and Development Center, in Vicksburg, Mississippi, examined nine rapid-setting materials for repair of PCC pavements through laboratory characterization and full-scale traffic tests. Standard laboratory tests were performed to characterize the material properties over time and to provide a mechanism for assessing the material suitability for field repairs. Repairs with approximate volumes of 0.7 m(3) (1.5 yd(3)) were constructed and evaluated under controlled traffic conditions to determine the ability of the repairs to support 100 simulated passes of an F-15E aircraft within 3 h of repair. Results of traffic tests identified seven repair materials that met these criteria. A laboratory protocol for selection of rapid-setting materials was developed based on the laboratory and full-scale test results. Use of the protocol will help prevent the selection of materials that are unlikely to meet performance expectations. C1 [Priddy, Lucy P.; Jersey, Sarah R.; Freeman, Reed B.] USA, Engineer Res & Dev Ctr, CEERD GM A, Vicksburg, MS 39180 USA. RP Priddy, LP (reprint author), USA, Engineer Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Lucy.p.priddy@usace.army.mil NR 13 TC 4 Z9 4 U1 1 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSP RES RECORD JI Transp. Res. Record PY 2009 IS 2113 BP 140 EP 148 DI 10.3141/2113-17 PG 9 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 536XJ UT WOS:000273076900017 ER PT J AU Morales, W Handschuh, RF Krantz, TL AF Morales, Wilfredo Handschuh, Robert F. Krantz, Timothy L. TI Feasibility Study of Vapor-Mist Phase Reaction Lubrication using a Thioether Liquid SO TRIBOLOGY TRANSACTIONS LA English DT Article DE Gears; Vapor Phase Lubrication ID IRON AB Aerospace drive systems are required to survive a loss-of-lubrication test for qualification. In many cases emergency lubrication systems need to be designed and utilized to permit the drive system to pass this difficult requirement. The weight of emergency systems can adversely affect the mission capabilities of the aircraft. The possibility to reduce the emergency system weight using vapor-mist phase lubrication (VMPL) technology has been considered by NASA and the Army Research Laboratory (ARL). Phosphate esters have been the lubricant of choice in most VMPL studies primarily because they do provide adequate lubrication for short periods of time. However, during the lubrication process, the phosphate esters react continuously with the surface iron in gears and bearings, resulting in excessive wear. To minimize this problem an alternative non-phosphate liquid, a thioether, was used to mist phase lubricate a spur gearbox rig operating at 10,000 rpm under highly loaded conditions. After 21 million shaft revolutions of operation the gears exhibited only minor wear. C1 [Morales, Wilfredo] NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. [Handschuh, Robert F.; Krantz, Timothy L.] US Army Res Lab, Glenn Res Ctr, Cleveland, OH 44135 USA. RP Morales, W (reprint author), NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. NR 11 TC 1 Z9 2 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1040-2004 J9 TRIBOL T JI Tribol. Trans. PY 2009 VL 52 IS 3 BP 370 EP 375 DI 10.1080/10402000802563448 PG 6 WC Engineering, Mechanical SC Engineering GA 424GS UT WOS:000264554700004 ER PT J AU Sescu, A Sescu, C Dimofte, F Cioc, S Afjeh, AA Handschuh, R AF Sescu, Adrian Sescu, Carmen Dimofte, Florin Cioc, Sorin Afjeh, Abdollah A. Handschuh, Robert TI A Study of the Steady-State Performance of a Pressurized Air Wave Bearing at Concentric Position SO TRIBOLOGY TRANSACTIONS LA English DT Article DE Air Bearings; Fluid Mechanics Methods; Turbulent Flow in Hydrodynamics ID HYBRID JOURNAL BEARINGS; RESTRICTORS AB The steady-state performance of a pressurized air wave bearing in concentric position is predicted using a commercial computational fluid dynamics (CFD) code. This code solves the three-dimensional compressible Navier-Stokes equations in the turbulent regime, taking into account the real geometry of both the bearing fluid film and the supply regions. The code can provide detailed information about the flow (pressure, turbulent kinetic energy distributions, velocity profiles, etc.) in all bearing regions including the supply holes. This approach does not involve a correction of the flow rate with an empirical discharge coefficient. The predicted values of the supply flow rates are compared to the experimental values obtained with a dedicated wave bearing test rig located at NASA Glenn Research Center in Cleveland, Ohio. C1 [Sescu, Adrian; Sescu, Carmen; Dimofte, Florin; Cioc, Sorin; Afjeh, Abdollah A.] Univ Toledo, MIME Dept, Toledo, OH 43606 USA. [Handschuh, Robert] USA, Res Lab, Cleveland, OH 44135 USA. RP Sescu, A (reprint author), Univ Toledo, MIME Dept, 2801 W Bancroft St,MS 312, Toledo, OH 43606 USA. NR 24 TC 6 Z9 6 U1 0 U2 5 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1040-2004 J9 TRIBOL T JI Tribol. Trans. PY 2009 VL 52 IS 4 BP 544 EP 552 DI 10.1080/10402000902774275 PG 9 WC Engineering, Mechanical SC Engineering GA 474JH UT WOS:000268279100007 ER PT B AU Collamer, AN Battafarano, DF AF Collamer, Angelique N. Battafarano, Daniel F. BE Rossard, TP TI Tumor Necrosis Factor Antagonist Induced Psoriatic Skin Lesions SO TUMOR NECROSIS FACTOR SE Cell Biology Research Progress LA English DT Article; Book Chapter ID NEW-ONSET PSORIASIS; FACTOR-ALPHA ANTAGONISTS; TNF-ALPHA; PALMOPLANTAR PUSTULOSIS; RHEUMATOID-ARTHRITIS; INFLIXIMAB TREATMENT; CROHNS-DISEASE; CASE SERIES; CUTANEOUS MANIFESTATIONS; GUTTATE PSORIASIS C1 [Collamer, Angelique N.; Battafarano, Daniel F.] Brooke Army Med Ctr, Dept Rheumatol, Ft Sam Houston, TX 78234 USA. RP Collamer, AN (reprint author), Brooke Army Med Ctr, Dept Rheumatol, Ft Sam Houston, TX 78234 USA. NR 78 TC 0 Z9 0 U1 0 U2 0 PU NOVA SCIENCE PUBLISHERS, INC PI HAUPPAUGE PA 400 OSER AVE, STE 1600, HAUPPAUGE, NY 11788-3635 USA BN 978-1-60741-708-8 J9 CELL BIO RES PROG PY 2009 BP 133 EP 141 PG 9 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA BPY76 UT WOS:000280375000005 ER PT J AU Fishman, B Forest, JJF AF Fishman, Brian Forest, James J. F. BE Normark, M Ranstorp, M TI WMD and the four dimensions of al-Qaeda SO UNCONVENTIONAL WEAPONS AND INTERNATIONAL TERRORISM: CHALLENGES AND NEW APPROACHES SE Cass Series on Political Violence LA English DT Article; Book Chapter C1 [Fishman, Brian; Forest, James J. F.] US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA. RP Fishman, B (reprint author), US Mil Acad, Combating Terrorism Ctr, West Point, NY 10996 USA. NR 28 TC 0 Z9 0 U1 0 U2 0 PU ROUTLEDGE PI NEW YORK PA 29 W 35TH ST, NEW YORK, NY 10001 USA BN 978-0-203-88195-8 J9 CASS SER POLIT VIOLE PY 2009 BP 29 EP 49 D2 10.4324/9780203881958 PG 21 WC International Relations; Political Science SC International Relations; Government & Law GA BMJ75 UT WOS:000272594700003 ER PT S AU Baran, D Fung, N Ho, S Sherman, J AF Baran, David Fung, Nick Ho, Sean Sherman, James BE Gerhart, GR Gage, DW Shoemaker, CM TI Detecting and tracking humans using a man-portable robot SO UNMANNED SYSTEMS TECHNOLOGY XI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology XI CY APR 17-17, 2009 CL Orlando, FL SP SPIE DE human detection; human tracking; Packbot; image processing; man-portable ID FEATURES AB Large gains in the automation of human detection and tracking techniques have been made over the past several years. Several of these techniques have been implemented on larger robotic platforms, in order to increase the situational awareness provided by the platform. Further integration onto a smaller robotic platform that already has obstacle detection and avoidance capabilities would allow these algorithms to be utilized in scenarios that are not plausible for larger platforms, such as entering a building and surveying a room for human occupation with limited operator intervention. However, transitioning these algorithms to a man-portable robot imparts several unique constraints, including limited power availability, size and weight restrictions, and limited processor ability. Many imaging sensors, processing hardware, and algorithms fail to adequately address one or more of these constraints. In this paper, we describe the design of a payload suitable for our chosen man-portable robot, the iRobot Packbot. While the described payload was built for a Packbot, it was carefully designed in order to be platform agnostic, so that it can be used on any man-portable robot. Implementations of several existing motion and face detection algorithms that have been chosen for testing on this payload are also discussed in some detail. C1 [Baran, David; Fung, Nick; Ho, Sean; Sherman, James] USA, Res Lab, Adelphi, MD 20783 USA. RP Baran, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7598-5 J9 PROC SPIE PY 2009 VL 7332 AR 733215 DI 10.1117/12.818813 PG 11 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Robotics; Optics SC Computer Science; Robotics; Optics GA BVS50 UT WOS:000292646300028 ER PT S AU O'Brien, BJ Sadler, L AF O'Brien, Barry J. Sadler, Laurel BE Gerhart, GR Gage, DW Shoemaker, CM TI Implementation of Small Robot Autonomy in an Integrated Environment SO UNMANNED SYSTEMS TECHNOLOGY XI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology XI CY APR 17-17, 2009 CL Orlando, FL SP SPIE DE autonomous mobility; SUGV; architecture; robotics; obstacle detection; obstacle avoidance; SLAM AB The U. S. Army Research Laboratory's (ARL) Computational and Information Sciences Directorate (CISD) has long been involved in autonomous asset control, specifically as it relates to small robots. Over the past year, CISD has been making strides in the implementation of three areas of small robot autonomy, namely platform autonomy, Soldier-robot interface, and tactical behaviors. It is CISD's belief that these three areas must be considered as a whole in order to provide Soldiers with useful capabilities. In addressing these areas, CISD has integrated a COTS LADAR into the head of an iRobot PackBot Explorer, providing ranging information with minimal disruption to the physical characteristics of the platform. Using this range data is an implementation of obstacle detection and avoidance (OD/OA), leveraged from an existing autonomy software suite, running on the platform's native processor. These capabilities will serve as the foundation of our targeted behavior-based control methodologies. The first behavior is guarded tele-operation that augments the existing ARL robotic control infrastructure. The second is the implementation of a multi-robot cooperative mapping behavior. Developed at ARL, collaborative simultaneous localization and mapping (CSLAM) will allow multiple robots to build a common map of an area, providing the Soldier operator with a singular view of that area. This paper will describe the hardware and software integration of the LADAR sensor into the ARL robotic control system. Further, the paper will discuss the implementation of the small robot OD/OA and CSLAM software components performed by ARL, as well as results on their performance and benefits to the Soldier. C1 [O'Brien, Barry J.; Sadler, Laurel] USA, Res Lab, Adelphi, MD 20783 USA. RP O'Brien, BJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7598-5 J9 PROC SPIE PY 2009 VL 7332 AR 73321U DI 10.1117/12.818494 PG 10 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Robotics; Optics SC Computer Science; Robotics; Optics GA BVS50 UT WOS:000292646300047 ER PT S AU O'Brien, BJ Karan, C Young, SH AF O'Brien, Barry J. Karan, Cem Young, Stuart H. BE Gerhart, GR Gage, DW Shoemaker, CM TI FOCU:S - Future Operator Control Unit: Soldier SO UNMANNED SYSTEMS TECHNOLOGY XI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology XI CY APR 17-17, 2009 CL Orlando, FL SP SPIE DE small robot; autonomy; OCU; touch-screen AB The U.S. Army Research Laboratory's (ARL) Computational and Information Sciences Directorate (CISD) has long been involved in autonomous asset control, specifically as it relates to small robots. Over the past year, CISD has been making strides in the implementation of three areas of small robot autonomy, namely platform autonomy, Soldier-robot interface, and tactical behaviors. It is CISD's belief that these three areas must be considered as a whole in order to provide Soldiers with useful capabilities. In addressing the Soldier-robot interface aspect, CISD has begun development on a unique dismounted controller called the Future Operator Control Unit: Soldier (FOCU:S) that is based on an Apple iPod Touch. The iPod Touch's small form factor, unique touch-screen input device, and the presence of general purpose computing applications such as a web browser combine to give this device the potential to be a disruptive technology. Setting CISD's implementation apart from other similar iPod or iPhone-based devices is the ARL software that allows multiple robotic platforms to be controlled from a single OCU. The FOCU:S uses the same Agile Computing Infrastructure (ACI) that all other assets in the ARL robotic control system use, enabling automated asset discovery on any type of network. Further, a custom ad hoc routing implementation allows the FOCU:S to communicate with the ARL ad hoc communications system and enables it to extend the range of the network. This paper will briefly describe the current robotic control architecture employed by ARL and provide short descriptions of existing capabilities. Further, the paper will discuss FOCU:S specific software developed for the iPod Touch, including unique capabilities enabled by the device's unique hardware. C1 [O'Brien, Barry J.; Karan, Cem; Young, Stuart H.] USA, Res Lab, Adelphi, MD 20783 USA. RP O'Brien, BJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 14 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7598-5 J9 PROC SPIE PY 2009 VL 7332 AR 73320P DI 10.1117/12.818495 PG 10 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Robotics; Optics SC Computer Science; Robotics; Optics GA BVS50 UT WOS:000292646300017 ER PT S AU Rogers, JR Korpela, C Quigley, K AF Rogers, John R. Korpela, Christopher Quigley, Kevin BE Gerhart, GR Gage, DW Shoemaker, CM TI Ten-kilogram vehicle autonomous operations SO UNMANNED SYSTEMS TECHNOLOGY XI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Unmanned Systems Technology XI CY APR 17-17, 2009 CL Orlando, FL SP SPIE DE unmanned ground vehicle; robot; low-cost; autonomy; high-speed AB A low-cost unmanned ground vehicle designed to benchmark high-speed performance is presented. The E-Maxx four-wheel-drive radio-controlled vehicle equipped with a Robostix controller is proposed as a low-cost, high-speed robotic platform useful for military operations. The vehicle weighs less than ten kilograms making it easily portable by one person. Keeping cost low is a major consideration in the design with the aim of providing a disposable military robot. The suitability of the platform was evaluated and results are presented. Commercial-Off-The-Shelf (COTS) upgrades to the basic vehicle are recommended for durability. A procedure was established for bird's-eye-view video recording to document vehicle dynamics. Driver/vehicle performance is quantified by entry velocity, exit velocity and total time through a 90 turn on low-friction terrain. A setup for measuring these values is presented. Expert drivers use controlled skidding to minimize time through turns and the long term goal of the project is to automate such expert behaviors. Results of vehicle performance under human control are presented and stand as a reference for future autonomy. C1 [Rogers, John R.; Korpela, Christopher; Quigley, Kevin] US Mil Acad, West Point, NY 10996 USA. RP Rogers, JR (reprint author), US Mil Acad, West Point, NY 10996 USA. EM john.rogers@usma.edu NR 13 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7598-5 J9 PROC SPIE PY 2009 VL 7332 AR 73321X DI 10.1117/12.818199 PG 8 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Robotics; Optics SC Computer Science; Robotics; Optics GA BVS50 UT WOS:000292646300049 ER PT J AU Alving, CR AF Alving, Carl R. BE Barrett, ADT Stanberry, LR TI Vaccine Adjuvants SO VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES LA English DT Article; Book Chapter ID ALUMINUM-CONTAINING ADJUVANTS; TOLL-LIKE RECEPTORS; CYTOTOXIC T-LYMPHOCYTES; PLASMODIUM-FALCIPARUM MALARIA; PROTEOSOME-INFLUENZA VACCINE; HYDROPHILE-LIPOPHILE BALANCE; ANTHRAX PROTECTIVE ANTIGEN; WATER LIPOSOMAL EMULSIONS; B SURFACE-ANTIGEN; DENDRITIC CELLS AB It is widely believed that adjuvants are important, and in some cases critical, for the success of most modern vaccines, particularly for new types of vaccines that have highly purified or synthetic antigens. Although aluminum salts are the most commonly used type of adjuvant for human vaccines, they are weak adjuvants that have complex mechanisms that favor induction of antibodies rather than cellular immunity. Aluminum salts do have a long record of relative safety, but they are also often responsible for local reactions at the site of injection, particularly for reactions that are associated with subcutaneous administration. Adjuvant selection for human vaccines still relies strongly on direct empirical testing of candidate adjuvants for safety and efficacy in humans. However, principles of innate immunity have been developed that provide some guidance for rational selection of adjuvants. New forms of vaccine adjuvants that have been proposed for various vaccines feature oil-based emulsions; bacterial products, such as lipid A, heat-labile E. coli enterotoxin, or CpG nucleotides; viral products, such as virus-like particles; plant products, such as saponin derivatives; biodegradable particles, such as liposomes; molecular adjuvants; and synthetic adjuvants. Adjuvant mechanisms include depot effects, recruitment of innate immunity mechanisms, specific targeting mechanisms, and carrier functions that hold the antigen in an appropriate conformation. The safety of proposed adjuvants is a primary consideration, and for this purpose it is often necessary to devise methods to reduce or eliminate the reactogenic effects of an adjuvant while preserving the efficacy. The most effective use of adjuvants for certain types of vaccines, particularly for stimulating mucosal immunity, may be to combine the adjuvant with a particular mode of delivery, such as oral, intranasal, or transcutaneous immunization. Carriers that carry and combine both the adjuvant and the antigen in a single formulation can serve as the basis for creation of important formulations for improved vaccines. C1 Walter Reed Army Inst Res, Dept Adjuvant & Antigen Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, Dept Adjuvant & Antigen Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. NR 136 TC 3 Z9 3 U1 1 U2 5 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-091902-7 PY 2009 BP 115 EP 129 DI 10.1016/B978-0-12-369408-9.00009-3 PG 15 WC Public, Environmental & Occupational Health; Immunology; Infectious Diseases SC Public, Environmental & Occupational Health; Immunology; Infectious Diseases GA BCR60 UT WOS:000311106000011 ER PT J AU Vaughn, DW Whitehead, SS Durbin, AP AF Vaughn, David W. Whitehead, Stephen S. Durbin, Anna P. BE Barrett, ADT Stanberry, LR TI Dengue SO VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES LA English DT Article; Book Chapter ID T-CELL RESPONSES; NEUTRALIZING ANTIBODY-RESPONSE; RECOMBINANT VACCINIA VIRUS; HUMAN ENDOTHELIAL-CELLS; DISSEMINATED INTRAVASCULAR COAGULATION; CLINICAL LABORATORY RESPONSES; RESPIRATORY SYNCYTIAL VIRUS; JAPANESE-ENCEPHALITIS-VIRUS; PERIPHERAL-BLOOD LEUKOCYTES; INTERFERON GAMMA-PRODUCTION AB Molecular evolution studies suggest that dengue virus (DENV) evolved 1000 years ago and entered a sustained human-mosquito cycle between 125 and 320 years ago. While it is unlikely that DENV would be used as a biothreat agent, DENV has emerged since World War II as the most important mosquito-borne viral pathogen infecting an estimated 100 million persons each year. Infection with any of the four DENV serotypes (DENV-1, 2, 3, and 4) can be inapparent, result in classic dengue fever with high fever, headache, eye pain and muscle ache, or progress at the time of defervescence to dengue hemorrhagic fever (DHF) characterized by hemorrhagic manifestations and plasma leakage that can lead to shock and death. The immunopathological mechanisms by which DENV causes the clinical features of DHF are intricate and include aberrant humoral and cellular immune responses. Previous DENV infections may predispose to more severe disease by the induction of enhancing antibody and cross-reactive T cells. Treatment is supportive relying upon careful fluid management which can be lifesaving. Prevention currently depends on vector control which has been largely unsuccessful. Several dengue vaccine candidates have advanced to clinical trials to include classically and molecularly attenuated live virus vaccines, chimeric vaccines using dengue and yellow fever virus backbones, and DNA vaccines. Whole virus inactivated and recombinant subunit vaccine candidates should soon enter into clinical testing. Live attenuated DENV vaccines offer the most promise in terms of broad, long-lasting protection, and although they are economical to produce, they may carry the risks of enhanced reactogenicity in recipients with preexisting flavivirus antibodies, adverse events among the immunocompromised, vaccine virus transmission by vector mosquitoes, and the risk of adventitious agents. Chimeric vaccine approaches use the same gene sequence for the nonstructural proteins for each of the four DENV serotypes avoiding the need for attenuating mutations in the structural genes and potentially reducing interference in the replication of the four virus vaccine components within the multivalent vaccine recipient. DNA vaccines, in combination with other approaches, may increase the complexity and effectiveness of the immune response. Whole inactivated virus approaches have been used successfully for other viral diseases, reduce interference issues in multivalent vaccines, and have protected nonhuman primates from viremia following challenge with wild-type virus. Recombinant subunit vaccines have also protected nonhuman primates from viremia and offer a more focused approach in an attempt to tailor antibody and cell-mediated immure responses. While pathogenesis studies seek to dissect immune responses in an attempt to avoid vaccine-related disease enhancement, these risks, which apply to all vaccine approaches, may need to be evaluated empirically. C1 [Vaughn, David W.] USA, Mil Infect Dis Res Program, Med Res & Dev Command, Ft Detrick, MD USA. [Whitehead, Stephen S.] NIAID, Infect Dis Lab, Bethesda, MD 20892 USA. [Durbin, Anna P.] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Immunizat Res, Dept Int Hlth, Baltimore, MD USA. RP Vaughn, DW (reprint author), USA, Mil Infect Dis Res Program, Med Res & Dev Command, Ft Detrick, MD USA. NR 356 TC 1 Z9 1 U1 1 U2 3 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-091902-7 PY 2009 BP 287 EP 324 PG 38 WC Public, Environmental & Occupational Health; Immunology; Infectious Diseases SC Public, Environmental & Occupational Health; Immunology; Infectious Diseases GA BCR60 UT WOS:000311106000021 ER PT B AU Hammerbeck, CD Wahl-Jensen, V Hooper, JW AF Hammerbeck, Christopher D. Wahl-Jensen, Victoria Hooper, Jay W. BE Barrett, ADT Stanberry, LR TI Hantavirus SO VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES LA English DT Article; Book Chapter ID SIN-NOMBRE-VIRUS; NECROSIS-FACTOR-ALPHA; KOREAN HEMORRHAGIC-FEVER; TO-PERSON TRANSMISSION; NEUTRALIZING ANTIBODY-RESPONSE; ENDOTHELIAL-CELL MIGRATION; PULMONARY-SYNDROME; HANTAAN-VIRUS; RENAL SYNDROME; NUCLEOCAPSID PROTEIN AB Hantaviruses are known to cause diseases of military and public health concern. The association of hantaviruses and war can be attributed to the fact that these viruses are carried by rodents and are transmitted to humans via rodent excreta. During sustained ground combat operations, human-rodent contact inevitably increases due to an increased number of personnel working and sleeping in the rodents' habitat, environmental disruption, and a breakdown in hygiene. During the Korean War, casualties caused by hantaviruses impacted military operations and spurred research aimed at identifying the etiological agent responsible for what was then known as Korean hemorrhagic fever, and developing countermeasures to prevent and treat the disease. This research resulted in the identification of multiple hantaviruses responsible for hemorrhagic fever with renal syndrome (HFRS), including Hantaan virus, Seoul virus, Dobrava virus, and Puumala virus. An ongoing effort to develop vaccines against these viruses has resulted in inactivated-virus vaccines that have been licensed in Asia. In addition, efforts to develop safe, effective molecular subunit vaccines against these viruses have shown promise. The only drug to show any clinical efficacy against HFRS is ribavirin used soon after the first symptoms of the disease. Ribavirin has not been licensed by the Food and Drug Administration (FDA) for use as a treatment for HFRS. The viruses associated with HFRS pose a relatively low threat as biological weapons because the viruses are difficult to grow to high titer, HFRS is not contagious, and the case-fatality rates range between 0.1% and 15%. However, starting in 1993, several previously unknown, highly pathogenic hantaviruses were discovered in the Americas. At least one of these viruses poses a substantial bioterrorism threat. Andes virus grows to levels ten times higher than the HFRS-associated hantaviruses, can spread from person to person under close-contact conditions, and is highly pathogenic (30-50% cases are fatal). Andes virus and several other newly emerging hantaviruses in the Americas are associated with rapid onset of pulmonary edema followed by cardiogenic shock. There are no vaccines or effective drugs to prevent or treat hantavirus pulmonary syndrome (HPS). Here, we review the viruses associated with HFRS and HPS with an emphasis on ongoing efforts to develop vaccines against these dangerous pathogens. C1 [Hammerbeck, Christopher D.; Wahl-Jensen, Victoria; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Hammerbeck, CD (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. OI Hooper, Jay/0000-0002-4475-0415 NR 249 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-091902-7; 978-0-12-369408-9 PY 2009 BP 379 EP 411 DI 10.1016/B978-0-12-369408-9.00023-8 PG 33 WC Public, Environmental & Occupational Health; Immunology; Infectious Diseases SC Public, Environmental & Occupational Health; Immunology; Infectious Diseases GA BCR60 UT WOS:000311106000025 ER PT J AU Venkatesan, M Kaminski, RW Ranallo, RT AF Venkatesan, Malabi Kaminski, Robert W. Ranallo, Ryan T. BE Barrett, ADT Stanberry, LR TI Shigellosis SO VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES LA English DT Article; Book Chapter ID O-SPECIFIC POLYSACCHARIDE; NF-KAPPA-B; ENTEROINVASIVE ESCHERICHIA-COLI; VACCINE CANDIDATE STRAINS; SHIGA-BACILLUS DYSENTERY; III SECRETION APPARATUS; LARGE VIRULENCE PLASMID; 2 ATTENUATING MARKERS; DELETED AROD GENE; FORM-I ANTIGEN AB Shigellosis is an acute, inflammatory gastrointestinal disease of humans and primates, characterized by diarrhea, fever, nausea, tenesmus, and often dysentery, which is excretion of bloody, small volume stool with mucus. It is caused by a gram-negative, nonmotile bacterium that is orally ingested in contaminated food and water. There are four major serogroups each with one or more serotypes that are differentiated by the structure of the LPS-linked O antigen. Shigella is a Category B pathogen and the ricin-like Shiga toxin produced by Shigella dysenteriae 1 strains can cause significant toxicity and sometimes hemolytic uremic syndrome which can be fatal. All virulent strains of Shigella carry a large nonconjugative similar to 220 kb plasmid, which encodes determinants that induce a phagocytic uptake within the colonic epithelial layer. Invasion is followed by intercellular spread within the tissue, resulting in necrosis and release of proinflammatory cytokines and chemokines. Eventually this leads to an infiltration of neutrophils at the site of inflammation and resolution of infection. Shigella infections lead to systemic and mucosal responses that are primarily against the LPS O-antigen polysaccharide. Hence, immunity is serotype-specific although some responses are also seen against the major plasmid-encoded invasion plasmid antigens. Over the last 50 years subunit vaccines based on presenting LPS to the mucosal system as well as live-attenuated noninvasive and invasive vaccines have been tested in Phase I and field trials. Many lessons have been learnt from these trials and today, a more complete understanding of the molecular details of pathogenesis has helped to design specific mutated Shigella strains that have shown promise as live oral vaccine candidates. At the same time, novel ways of introducing the LPS antigen to the host strains are being evaluated as subunit vaccine candidates with significant success. Currently, only a single live, noninvasive bivalent Shigella vaccine exists in China which provides similar to 60% efficacy in adults. In the next few years a mixture of the current crop of vaccine candidates, both live and subunit, as well as combinations of the two types of vaccines will undergo testing in Phase I, II, and possibly Phase III trials. Data from these studies is expected to provide for a safe and effective vaccine development strategy that will protect against the predominant circulating serotypes of Shigella seen worldwide. C1 [Venkatesan, Malabi; Kaminski, Robert W.; Ranallo, Ryan T.] Walter Reed Army Inst Res, Dept Pediat, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP Venkatesan, M (reprint author), Walter Reed Army Inst Res, Dept Pediat, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. NR 222 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-091902-7 PY 2009 BP 1163 EP 1192 DI 10.1016/B978-0-12-369408-9.00058-5 PG 30 WC Public, Environmental & Occupational Health; Immunology; Infectious Diseases SC Public, Environmental & Occupational Health; Immunology; Infectious Diseases GA BCR60 UT WOS:000311106000060 ER PT J AU Richie, TL Parekh, FK AF Richie, Thomas L. Parekh, Falgunee K. BE Barrett, ADT Stanberry, LR TI Malaria SO VACCINES FOR BIODEFENSE AND EMERGING AND NEGLECTED DISEASES LA English DT Article; Book Chapter ID PLASMODIUM-FALCIPARUM MALARIA; BLOOD-STAGE MALARIA; MEROZOITE SURFACE PROTEIN-3; APICAL MEMBRANE ANTIGEN-1; YOELII CIRCUMSPOROZOITE PROTEIN; HUMORAL IMMUNE-RESPONSES; GLUTAMATE-RICH PROTEIN; VACCINIA VIRUS ANKARA; PRIME-BOOST IMMUNIZATION; DUFFY-BINDING-PROTEIN AB Malaria is the most important parasitic disease with its vast distribution across the tropics and subtropics, immense public health burden, and tremendous economic impact on affected populations. Efforts to control malaria are being conducted on multiple fronts including vector control through residual house spraying, distribution of insecticide-treated bednets and improved diagnosis and treatment, including the development of new drugs and drug combinations effective against resistant strains. Despite these efforts, malaria remains prevalent in at least 87 countries with approximately 40% of the world's population living at risk; the greatest burden of malaria falls on young children with one child dying from malaria every 30s. Civil disturbance, inadequate health infrastructure, and poverty contribute to the lack of effective control. Experience with other infections such as smallpox, measles, and polio demonstrates that vaccines can be a highly effective and cost-efficient method of controlling an infectious agent with global impact. The complexity of the malarial parasite has made the task of developing an efficacious vaccine difficult. Malaria is a vector-borne disease caused by a protozoan parasite of the genus Plasmodium, and transmitted by the bite of an Anopheles mosquito. The Plasmodium parasite has a complex life cycle with multiple stages, differential expression of antigens with each stage, and a high degree of antigenic variability. Additionally, unlike smallpox, measles, and many other infectious agents, protective immunity develops slowly, requires repeated infections, is never strong enough to prevent reinfection, and is quickly lost in the absence of exposure. Despite these challenges, there are two models of immunity that support the feasibility of developing a malaria vaccine: (1) immunization with radiation-attenuated sporozoites, which induces sterile protection against the sporozoite and liver stages of the parasite and (2) naturally acquired immunity, which is characterized by partial protection against the asexual blood stages. These models provide the basis for many of the malaria vaccine candidates currently under development, including vaccines designed to prevent infection (targeting sporozoite and liver stages) or to prevent disease (targeting blood stages). In addition, the sexual stages of the parasite can be targeted by vaccines designed to prevent transmission, an intriguing approach aimed at communitywide as opposed to individual benefit. Currently, over 50 malaria vaccine candidates have reached various stages of clinical development. Most are subunit vaccines based on one or few antigens, and target one particular stage of the parasite life cycle. The subunit vaccines are constructed using a variety of platforms, including synthetic peptides or recombinant protein in adjuvant, viral vectors, DNA plasmids, and prime-boost combinations of these platforms. As it has become more apparent that a single antigen may not be sufficient to induce strong protective immunity against such a complex organism, a multiantigen, multistage approach is also being explored. More recently, there is focus on the attenuated whole parasite approach, which precludes the need to identify the antigens or immune mechanisms associated with protection. This chapter will provide a summary of the history, biology, epidemiology, and clinical pathology of this important disease, and will then review progress in developing an effective malaria vaccine for widespread use. C1 [Richie, Thomas L.; Parekh, Falgunee K.] USN, US Mil Malaria Vaccine Program, Med Res Ctr, Walter Reed Army Inst Res, Silver Spring, MD USA. RP Richie, TL (reprint author), USN, US Mil Malaria Vaccine Program, Med Res Ctr, Walter Reed Army Inst Res, Silver Spring, MD USA. OI Richie, Thomas/0000-0002-2946-5456 NR 489 TC 2 Z9 2 U1 4 U2 14 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-08-091902-7 PY 2009 BP 1309 EP 1364 DI 10.1016/B978-0-12-369408-9.00065-2 PG 56 WC Public, Environmental & Occupational Health; Immunology; Infectious Diseases SC Public, Environmental & Occupational Health; Immunology; Infectious Diseases GA BCR60 UT WOS:000311106000067 ER PT J AU McCary, JA AF McCary, John A. TI The Anbar Awakening: An Alliance of Incentives SO WASHINGTON QUARTERLY LA English DT Article C1 USA, Washington, DC 20310 USA. RP McCary, JA (reprint author), USA, Washington, DC 20310 USA. EM john@writtenlife.com NR 31 TC 19 Z9 19 U1 0 U2 3 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0163-660X J9 WASH QUART JI Wash. Q. PD JAN PY 2009 VL 32 IS 1 BP 43 EP 59 PG 17 WC International Relations; Law SC International Relations; Government & Law GA 387CK UT WOS:000261929100003 ER PT J AU Foster, JR AF Foster, J. R. TI Do Texas groundwater conservation districts matter? SO WATER POLICY LA English DT Article DE Fixed effects; Groundwater conservation districts; Groundwater depletion; Panel data ID PROPERTY-RIGHTS REGIME; EXHAUSTIBLE RESOURCES; COMMON PROPERTY; PRIVATE; MANAGEMENT; ECONOMICS; AQUIFER; SYSTEM; POLICY; WATER AB Texas faces a number of issues in an attempt to balance the water needs of a growing population while at the same time trying to conserve its water resources. Some of these issues include infrastructure improvements and provision of new supplies, changing patterns of use, water marketing and aquifer depletion. With aquifers providing 60% of all the water used in Texas, protecting and keeping these sources viable in the future is a key priority in addressing the state's water issues. With the state's emphasis on local control and the existence of between 80 and 90 groundwater districts state-wide, this research seeks to answer the question "Do groundwater districts in the State of Texas make a difference in groundwater depletion?" We use panel data from a set of 8,110 observations in a fixed effects regression to help us answer this question. We find evidence to suggest that groundwater districts do make a difference. After taking into consideration a couple of potential threats to validity, we run our model on a per district basis and by groundwater management areas. We also run it on a per aquifer basis and compare results with recommendations in the 2007 Texas Water Plan as a reality check. If we successfully answer the question that districts do in fact matter, the next logical step is to investigate what it is that districts do that makes a difference. C1 [Foster, J. R.] Univ Texas Dallas, Sch Econ Polit & Policy Sci, Richardson, TX 75083 USA. [Foster, J. R.] USA, Corps Engineers, Planning Branch, Ft Worth, TX 76102 USA. RP Foster, JR (reprint author), Univ Texas Dallas, Sch Econ Polit & Policy Sci, Richardson, TX 75083 USA. EM Jodie.R.Foster@usace.army.mil NR 35 TC 0 Z9 0 U1 0 U2 4 PU I W A PUBLISHING PI LONDON PA ALLIANCE HOUSE, 12 CAXTON ST, LONDON SW1H0QS, ENGLAND SN 1366-7017 J9 WATER POLICY JI Water Policy PY 2009 VL 11 IS 3 BP 379 EP 399 DI 10.2166/wp.2009.015 PG 21 WC Water Resources SC Water Resources GA 456XH UT WOS:000266885700008 ER PT S AU Ashby, S Richards, D Wallace, R AF Ashby, S. Richards, D. Wallace, R. BE Brebbia, CA Popov, V TI Simple to complex tools for sustainable water resource management SO WATER RESOURCES MANAGEMENT V SE WIT Transactions on Ecology and the Environment LA English DT Proceedings Paper CT 5th International Conference on Sustainable Water Resources Management CY SEP 09-11, 2009 CL MALTA SP Wessex Inst Technol, WIT Transact Ecol & Environm DE watersheds; geospatial; modeling; habitat; visualization AB The U.S. Army Corps of Engineers has developed a system of tools to improve environmental forecasting and decision-making in comprehensive water resources management. Currently available tools include geospatial assessment techniques, habitat and index-based models, single- and multi-dimensional numerical models, and ecological models based on concepts of bioenergetics, individual-based response, and trophic structure. Applications of these models for sustainable water resource management provide opportunities to assess and predict landscape changes, owing to activities such as urbanization, ecosystem restoration, water resource project operations, etc. at various temporal and spatial scales. Since resources (e.g., data, time, expertise, funding, etc) are often limited, a tiered or hierarchical approach to water resources management is recommended. For example, geospatial technologies can be used to develop land cover and land use data layers for applications in habitat-based models or numerical models for watershed runoff predictions. Index-based models can be used in conjunction with stakeholder-developed performance criteria to forecast potential adaptive management trajectories for sustained and multi-purpose use of water resources. Another level of water resource assessment combines predictions of land use changes and subsequent changes in material loadings with potential biological response in aquatic systems using multi-dimensional models. This suite of tools has been developed within a framework to "customize" comprehensive tool selection in the decision-making process, thus ultimately allowing user communities to maintain databases, conduct alternative analyses, and transfer information in a user-friendly format. Selected case study applications are presented to demonstrate this concept. C1 [Ashby, S.; Richards, D.; Wallace, R.] USA, Engineer Res & Dev Ctr, Washington, DC USA. RP Ashby, S (reprint author), USA, Engineer Res & Dev Ctr, Washington, DC USA. NR 5 TC 0 Z9 0 U1 1 U2 5 PU WIT PRESS PI SOUTHAMPTON PA ASHURST LODGE, SOUTHAMPTON SO40 7AA, ASHURST, ENGLAND SN 1743-3541 BN 978-1-84564-199-3 J9 WIT TRANS ECOL ENVIR PY 2009 VL 125 BP 47 EP 54 DI 10.2495/WRM090051 PG 8 WC Ecology; Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA BMM56 UT WOS:000272819300005 ER PT J AU Wilson, DK Ostashev, VE Lewis, MS AF Wilson, D. Keith Ostashev, Vladimir E. Lewis, Matthew S. TI Moment-screen method for wave propagation in a refractive medium with random scattering SO WAVES IN RANDOM AND COMPLEX MEDIA LA English DT Article ID RANDOM INTERNAL WAVES; SOUND-PROPAGATION; PARABOLIC-EQUATION; TURBULENT ATMOSPHERE; OCEAN; FIELD; MODEL; FLUCTUATIONS; STATISTICS; GUIDE AB Direct numerical solution of a parabolic equation (PE) for the second moment of the sound field in a refracting medium with random scattering is described. The method determines the mean-square sound pressure without requiring generation of random realizations of the propagation medium. The second-moment matrix is factored into components that are independently propagated with a conventional PE algorithm. A moment screen is periodically applied to attenuate the coherence of the wavefield, much as phase screens are often applied in the method of random realizations. An example involving upwind and downwind propagation in the near-ground atmosphere shows that the new direct method converges to an accurate solution faster than the method of random realizations and is particularly well suited to calculations at low frequencies. C1 [Wilson, D. Keith; Lewis, Matthew S.] USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Ostashev, Vladimir E.] NOAA, Earth Syst Res Lab, Boulder, CO 80305 USA. [Ostashev, Vladimir E.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. RP Wilson, DK (reprint author), USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. EM d.keith.wilson@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU US Army Engineer Research and Development Center FX This research was sponsored by the US Army Engineer Research and Development Center. We thank the reviewers for their insightful comments on the initial version of this article. NR 24 TC 4 Z9 4 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1745-5030 J9 WAVE RANDOM COMPLEX JI Waves Random Complex Media PY 2009 VL 19 IS 3 BP 369 EP 391 AR PII 910562379 DI 10.1080/17455030802647462 PG 23 WC Physics, Multidisciplinary SC Physics GA 558NO UT WOS:000274750800001 ER PT J AU Tong, MS Ting, LY Chew, WC White, MJ AF Tong, Mei Song Ting, Leon Yeow Chew, Weng Cho White, Michael J. TI A study for sound wave scattering by corrugated ground with complex trench structures SO WAVES IN RANDOM AND COMPLEX MEDIA LA English DT Article ID BLAST NOISE; LARGE FIREARMS; SNOW COVER; PROPAGATION; PREDICTION; ATMOSPHERE; REDUCTION; SURFACES; ARTILLERY; IMPEDANCE AB Several trench structures in corrugated ground are investigated for the possibility of mitigating gun blast noise by numerical simulations. The blast noise usually includes large explosive energy with nonlinearity in the near field and exhibits a very low-frequency spectrum. In this study, the linearity approximation for the noise is taken because the nonlinearity of the wave reaching the scatterer is not serious for many proved guns and the low-frequency characteristic is concentrated. The structures are designed based on the surface impedance design approach proposed in our previous work and arbitrary three-dimensional (3D) geometries within a truncated ground are now assumed. The acoustic characteristic of the structures is evaluated by using a fast numerical solver. The solver employs the multilevel fast multipole algorithm (MLFMA) as an accelerator and can solve very large acoustic wave scattering problems with millions of unknowns on workstations within several days. This tool allows us to truncate the ground as large as needed for accurate modeling. Four structures are mainly considered in the design, namely, concentric trenches, sectorial trapezoidal trenches, interlaced arc trenches and parabolic reflectors. Some of them may have a sloped inner wall or tilted surface as a means of adjustment. Numerical simulations show that the concentric trench design has a very good mitigation behavior for linear and continuous noise sources and the structure is further studied for mitigating real-world gun blast noise. C1 [Tong, Mei Song; Ting, Leon Yeow; Chew, Weng Cho] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. [White, Michael J.] US Army Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Chew, WC (reprint author), Univ Illinois, Dept Elect & Comp Engn, 1406 W Green St, Urbana, IL 61801 USA. EM w-chew@uiuc.edu RI White, Michael/B-3612-2009; Chew, Weng Cho/C-1792-2009 OI White, Michael/0000-0001-8450-9135; FU Construction Engineering Research Laboratory (CERL), US Army [W9132T-06-2-0006] FX This work was supported by Construction Engineering Research Laboratory (CERL), US Army, under the grant W9132T-06-2-0006. NR 39 TC 0 Z9 0 U1 0 U2 3 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1745-5030 J9 WAVE RANDOM COMPLEX JI Waves Random Complex Media PY 2009 VL 19 IS 3 BP 392 EP 408 AR PII 910562218 DI 10.1080/17455030902725630 PG 17 WC Physics, Multidisciplinary SC Physics GA 558NO UT WOS:000274750800002 ER PT J AU Ostashev, VE Collier, SL Wilson, DK AF Ostashev, Vladimir E. Collier, Sandra L. Wilson, D. Keith TI Transverse-longitudinal coherence function of a sound field for line-of-sight propagation in a turbulent atmosphere SO WAVES IN RANDOM AND COMPLEX MEDIA LA English DT Article ID WAVES; PLANE; PERFORMANCE; ARRAYS AB Using the narrow-angle and Markov approximations, a formula for the transverse-longitudinal coherence function of a sound field propagating in a turbulent atmosphere with temperature and wind velocity fluctuations is derived. This function, which applies to observation points that are arbitrarily located in space, generalizes the transverse coherence function (coherence when the observation points are in a plane perpendicular to the sound propagation path), which has been studied extensively. The new result is expressed in terms of the transverse coherence function and the extinction coefficient of the mean sound field. The transverse-longitudinal coherence function of a plane sound wave is then calculated and studied in detail for the Gaussian and von Karman spectra of temperature and wind velocity fluctuations. It is shown, for relatively small propagation distances, that the magnitude of the coherence function decreases in the longitudinal direction but remains almost constant in the transverse direction. On the other hand, for moderate and large propagation distances, the magnitude of the coherence decreases faster in the transverse direction than in the longitudinal. For some parameters of the problem, the coherence function has relatively large local maxima and minima as the transverse and longitudinal coordinates are varied. With small modifications, many results obtained in the paper can be applied to studies of electromagnetic wave propagation in a turbulent atmosphere. C1 [Ostashev, Vladimir E.] NOAA, Earth Syst Res Lab, Boulder, CO 80305 USA. [Ostashev, Vladimir E.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. [Collier, Sandra L.] USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. [Wilson, D. Keith] USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Ostashev, VE (reprint author), NOAA, Earth Syst Res Lab, 325 Broadway, Boulder, CO 80305 USA. EM vladimir.ostashev@noaa.gov RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 25 TC 2 Z9 2 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1745-5030 J9 WAVE RANDOM COMPLEX JI Waves Random Complex Media PY 2009 VL 19 IS 4 BP 670 EP 691 DI 10.1080/17455030903038504 PG 22 WC Physics, Multidisciplinary SC Physics GA 558NQ UT WOS:000274751000006 ER PT J AU Mudge, CR Haller, WT AF Mudge, Christopher R. Haller, William T. TI Ornamental and Row Crop Susceptibility to Flumioxazin in Overhead Irrigation Water SO WEED TECHNOLOGY LA English DT Article DE Aquatic; nontarget injury; herbicide injury; EC(10); effective concentration 10 ID PEANUT ARACHIS-HYPOGAEA; WEED MANAGEMENT; PROTOPORPHYRINOGEN OXIDASE; PLANT TOLERANCES; STRIP-TILLAGE; ENDOTHALL; HERBICIDES; FLURIDONE; PREPLANT; DIQUAT AB The effects of flumioxazin in irrigation water were evaluated on four row crop species (corn, cotton, soybean, and wheat) and three ornamental species (begonia, impatiens, and snapdragon). Plants were overhead irrigated one time with flumioxazin at concentrations of 0, 10, 25, 50, 100, 200, 400, 800, 1,600, and 3,200 mu g ai/L in water equivalent to 1.27 cm. Ornamental plant tolerances on the basis of a 10% reduction in dry weight (effective concentration 10 [EC(10)]) were as follows: impatiens (40) < begonia (103) < snapdragon (7,024). The EC(10) values of flumioxazin on the basis of dry weight values for row crop species were wheat (35) < corn experiment 1 (53) < cotton. (106) < corn experiment 2 (181) < soybean (193). EC(10) values for plant height were similar to values for plant dry weight for ornamental and crop species. Snapdragon was the only plant evaluated that was mature at the time of treatment; consequently, all other species were moderately to highly sensitive to irrigation water containing flumioxazin. These data show that flumioxazin can injure and kill immature ornamental and crop species within the potential maximum concentration of 400 mu g/L; however, the very short half-life of this herbicide in water with pH 7.0 to 9.0 (ca. 16 h to 17 min) could result in less injury than suggested in this study. C1 [Mudge, Christopher R.; Haller, William T.] Univ Florida, Inst Food & Agr Sci, Ctr Aquat & Invas Plants, Gainesville, FL 32611 USA. RP Mudge, CR (reprint author), USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Christopher.R.Mudge@usace.army.mil FU Aquatic Ecosystem Restoration Foundation; Valent U.S.A. Corporation FX We thank the Aquatic Ecosystem Restoration Foundation and Valent U.S.A. Corporation for partial funding of this research. NR 38 TC 3 Z9 3 U1 0 U2 4 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0890-037X J9 WEED TECHNOL JI Weed Technol. PD JAN-MAR PY 2009 VL 23 IS 1 BP 89 EP 93 DI 10.1614/WT-08-024.1 PG 5 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA 423CG UT WOS:000264473400015 ER PT B AU Meghanathan, N Milton, LC AF Meghanathan, Natarajan Milton, Leslie C. GP IEEE TI A Simulation Based Performance Comparison Study of Stability-Based Routing, Power-Aware Routing and Load-Balancing On-Demand Routing Protocols for Mobile Ad hoc Networks SO WONS 2009: SIXTH INTERNATIONAL CONFERENCE ON WIRELESS ON-DEMAND NETWORK SYSTEMS AND SERVICES LA English DT Proceedings Paper CT 6th International Conference on Wireless On-Demand Network Systems and Services CY FEB 02-04, 2009 CL Snowbird, UT AB The high-level contribution of this paper is a simulation-based detailed performance comparison of three different classes of on-demand routing protocols for mobile ad hoc networks: stability-based routing, power-aware routing and load-balanced routing. We choose the Flow-Oriented Routing protocol (FOR-P), Min-Max Battery Cost Routing (MMBCR) and the traffic interference based Load Balancing Routing (LBR) protocol as representatives of the stability-based routing, power-aware routing and load-balancing routing protocols respectively. FORP incurs the least number of route transitions; while LBR incurs the smallest hop count and lowest end-to end delay per data packet. Energy consumed per data packet is the least for LBR, closely followed by MMBCR. FORP incurs the maximum energy consumed per data packet, both in the absence and presence of power control. Nevertheless, in the presence of power control, the end-to-end delay per data packet and energy consumed per data packet incurred by FORP are significantly reduced compared to the scenario without power control. MMBCR is the most fair in terms of node usage and incurs the largest time for first node failure. FORP tends to repeatedly use nodes lying on the stable path and hence is the most unfair of the three routing protocols. FORP also incurs the smallest value for the time of first node failure. C1 [Meghanathan, Natarajan] Jackson State Univ, Jackson, MS 39217 USA. [Milton, Leslie C.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Meghanathan, N (reprint author), Jackson State Univ, Jackson, MS 39217 USA. EM nmeghanathan@jsums.edu; Leslie.C.Milton@usace.anny.mil NR 20 TC 0 Z9 0 U1 2 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3374-2 PY 2009 BP 1 EP + PG 2 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA BKQ21 UT WOS:000268929600001 ER PT J AU Rice, VJB Mays, MZ Gable, C AF Rice, Valerie J. Berg Mays, Mary Z. Gable, Clayton TI Self-reported health status of students in-processing into military medical advanced individual training SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE Musculoskeletal injury; risk factors; screening; stress; fitness ID RISK-FACTORS; INJURIES; ARMY; EPIDEMIOLOGY; WOMEN; MEN AB It is important to be aware of the health and injury status of students in military training settings in order to adequately plan for their progression through required physical training and provision of health care to meet their needs. This paper describes the self-reported health status of students arriving in two medical training Battalions at Ft. Sam Houston. The results revealed that 43% of arriving soldiers had musculoskeletal symptoms and 35% had symptoms that interfered with their ability to accomplish the normal daily activities required as students. The most common sites of symptoms were knee (17 and 18%), foot/toe (16 and 13%), ankle (9 and 10%), and lower leg (9 and 12%) for the 232(nd) and 187(th) Medical Battalions respectively. Risk factors for those with musculoskeletal injury (MSI) symptoms that interfere with their abilities to do their jobs include gender, past history of injury, and self-reported stress and fitness levels. Other risk factors for medical specialties other than combat medic include being older (over 24 yrs of age), active duty status, being overweight, and use of smokeless tobacco. This information can help identify soldiers considered at risk of incurring a MSI during AIT. With this knowledge, physical training can be designed to help soldiers achieve fitness without additional injury and health care facilities can be designed to provide appropriate staffing of the health care professionals needed for evaluation and treatment. C1 [Rice, Valerie J. Berg] Army Med Dept Ctr, Human Res & Engn Directorate, Army Res Lab, Ft Sam Houston, TX 78234 USA. [Rice, Valerie J. Berg] Sch Field Element, Ft Sam Houston, TX 78234 USA. [Mays, Mary Z.] Arizona State Univ, Coll Nursing & Hlth Innovat, Phoenix, AZ USA. [Gable, Clayton] Headquarters US Army Med Command, Hlth Policy & Serv, Behav Hlth Div, Army Cent Registry, Ft Sam Houston, TX USA. RP Rice, VJB (reprint author), Army Med Dept Ctr, Human Res & Engn Directorate, Army Res Lab, 2421 FSH Hood St, Ft Sam Houston, TX 78234 USA. EM Valerie.Rice@amedd.army.mil NR 19 TC 1 Z9 1 U1 0 U2 2 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2009 VL 34 IS 4 BP 387 EP 400 DI 10.3233/WOR-2009-0939 PG 14 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 545SE UT WOS:000273756200002 PM 20075516 ER PT J AU Rice, VJ Vu, T Butler, J Marra, D Merullo, D Banderet, L AF Rice, Valerie J. Vu, Tan Butler, Jenny Marra, Diane Merullo, Donna Banderet, Louis TI Fear of failure: Implications for military health care specialist student training SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article ID CLAIMED SELF-HANDICAPS; DEFENSIVE PESSIMISM; PERFORMANCE FAILURE; APPRAISAL INVENTORY; MOTIVATION; ACHIEVEMENT; CONSEQUENCES; RESPONSES; OPTIMISM; ANXIETY AB During scholastic or physical performance testing, individuals who fear failure tend to focus on their fears instead of the task and often perform poorly. This study examined the relationship between fear-of-failure (FoF) and performance among 200 students (male = 140, female = 60) attending Health Care Specialist Advanced Individual Training (AIT) at Ft. Sam Houston. Performance measures included grade point average, pass/fail status, Army Physical Fitness Test scores, and number of musculoskeletal injuries. Pearson Product Moment Correlations revealed that Soldiers who scored higher on a FoF scale also had higher final grades (r = 0.16, p = 0.02, r(2) = 0.026). No significant correlations were found between FoF and other performance measures. While the variation in GPA accounted for by FoF was small (2.6%), this finding demonstrates a positive relationship that differs from previous studies. This finding may be explained by the concepts of failure avoidance and success orientation (self confidence and motivation), as well as the unique military setting. Suggestions for designing military educational interventions during AIT and throughout one's military career are offered. C1 [Rice, Valerie J.] Army Med Dept Ctr, Human Res & Engn Directorate, Army Res Lab, Ft Sam Houston, TX 78234 USA. [Rice, Valerie J.] Sch Field Element, Ft Sam Houston, TX 78234 USA. [Merullo, Donna; Banderet, Louis] USA, Environm Med Res Inst, Washington, DC 20310 USA. RP Rice, VJ (reprint author), Army Med Dept Ctr, Human Res & Engn Directorate, Army Res Lab, 1750 Greely Rd,STE 219, Ft Sam Houston, TX 78234 USA. EM Valerie.Rice@amedd.army.mil NR 38 TC 1 Z9 1 U1 1 U2 7 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 EI 1875-9270 J9 WORK JI Work PY 2009 VL 34 IS 4 BP 465 EP 474 DI 10.3233/WOR-2009-0947 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 545SE UT WOS:000273756200010 PM 20075524 ER PT J AU Shuping, E Canham-Chervak, M Amoroso, PJ Jones, BH AF Shuping, Eric Canham-Chervak, Michelle Amoroso, Paul J. Jones, Bruce H. TI Identifying modifiable causes of fall-related injury: An analysis of US Army safety data SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION LA English DT Article DE Injury; epidemiology; occupational; falls; elevation; height; military; safety ID CONSTRUCTION FALLS; UNION CARPENTERS; PATTERNS; ALCOHOL; SLIPS; TEXT AB Details on fall-related circumstances, a leading cause of occupational injury, are scarce. This study aimed to identify modifiable causes of falls using data from safety reports. Coded and narrative data on injured persons, event locations, and circumstances associated with falls sustained by U. S. Army personnel were obtained from safety reports dated September 1994 September 2002. Descriptive statistics are presented for injury outcomes and risk factors, with a focus on falls from elevation. On average, 59 fall-related injuries/100,000 person-years were reported. Higher rates occurred among whites, single persons, and 20-24 year-olds. Falls from elevation resulted in more severe outcomes, longer hospitalizations, and more lost work time compared to falls from the same level. Most falls from elevation occurred in training (32%) and housing (18%) areas. Leading causes included routine activities (e. g., walking, entering/exiting vehicles) (35%), physical training (12%), and sports (12%). Interventions to prevent falls from elevation in this population should focus on reducing risks from routine activities, specifically in training and housing areas. Safety reports provided details necessary for prioritizing and planning fall prevention efforts that are not available from other sources. C1 [Shuping, Eric] Ireland Army Community Hosp, Ft Knox, KY 40121 USA. [Canham-Chervak, Michelle; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, Bethesda, MD USA. [Amoroso, Paul J.] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Shuping, E (reprint author), Ireland Army Community Hosp, 851 Ireland Loop, Ft Knox, KY 40121 USA. EM eric.e.shuping@us.army.mil NR 37 TC 2 Z9 2 U1 0 U2 1 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1051-9815 J9 WORK JI Work PY 2009 VL 33 IS 1 BP 23 EP 34 DI 10.3233/WOR-2009-0840 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 480FD UT WOS:000268716800004 PM 19597282 ER PT J AU Case, FH Brennan, J Chaka, A Dobbs, KD Friend, DG Gordon, PA Moore, JD Mountain, RD Olson, JD Ross, RB Schiller, M Shen, VK Stahlberg, EA AF Case, Fiona H. Brennan, John Chaka, Anne Dobbs, Kerwin D. Friend, Daniel G. Gordon, Peter A. Moore, Jonathan D. Mountain, Raymond D. Olson, James D. Ross, Richard B. Schiller, Martin Shen, Vincent K. Stahlberg, Eric A. TI The fourth industrial fluid properties simulation challenge SO FLUID PHASE EQUILIBRIA LA English DT Article DE Force field; Intermolecular potential; Molecular simulation; Simulation challenge ID MOLECULAR-DYNAMICS SIMULATION; VAPOR-LIQUID-EQUILIBRIA; HENRYS LAW CONSTANTS; MONTE-CARLO SIMULATIONS; BUBBLE POINT PRESSURE; ETHYLENE-OXIDE; FORCE-FIELD; ESTABLISHING BENCHMARKS; CARBON-DIOXIDE; PREDICTION AB The primary goal of the fourth industrial fluid properties simulation challenge was to test the transferability of molecular simulation methods and intermolecular potentials (force fields) when applied to a wide variety of physical properties for a given industrially relevant small molecule. Force field parameters are often developed for, tested with, and applied to a relatively limited range property types. Methods that are able to predict a broad range of properties may be more useful for practical application in an industrial setting. To address this primary goal, entrants were challenged to develop new intermolecular potential models for ethylene oxide (EO) and to us they predict a variety of physical properties. The predictions were judged by comparison to a set of benchmark values established based on peer-reviewed scientific literature and highly regarded property databases, and the results were generally excellent. A secondary objective was to assess the variability of those property predictions when performed by different researchers using the same force field (a "round-robin" experiment). To address this goal, entrants were challenged to calculate the same set of properties for a specific EO potential model from the literature, and good consistency was found between the predictions of most of the entrants. (c) 2008 Elsevier B.V. All rights reserved. C1 [Chaka, Anne; Mountain, Raymond D.; Shen, Vincent K.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. [Case, Fiona H.] Case Sci, Essex Jct, VT USA. [Brennan, John] USA, Res Lab, Aberdeen Proving Ground, MD USA. DuPont Co Inc, Wilmington, DE USA. [Friend, Daniel G.] NIST, Boulder, CO USA. [Gordon, Peter A.] ExxonMobil, Annandale, NJ USA. [Moore, Jonathan D.] Dow Chem Co USA, Midland, MI 48674 USA. [Olson, James D.] Dow Chem Co USA, S Charleston, WV USA. [Ross, Richard B.] 3M Co, St Paul, MN 55144 USA. [Stahlberg, Eric A.] Ohio Supercomp Ctr, Columbus, OH USA. RP Mountain, RD (reprint author), Natl Inst Stand & Technol, 100 Bur Dr Stop 8380, Gaithersburg, MD 20899 USA. EM Raymond.Mountain@nist.gov RI Moore, Jonathan/B-8201-2009 NR 37 TC 26 Z9 26 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3812 J9 FLUID PHASE EQUILIBR JI Fluid Phase Equilib. PD DEC 25 PY 2008 VL 274 IS 1-2 BP 2 EP 9 DI 10.1016/j.fluid.2008.05.009 PG 8 WC Thermodynamics; Chemistry, Physical; Engineering, Chemical SC Thermodynamics; Chemistry; Engineering GA 381WG UT WOS:000261566000002 ER PT J AU Mulligan, CP Blanchet, TA Gall, D AF Mulligan, C. P. Blanchet, T. A. Gall, D. TI CrN-Ag nanocomposite coatings: Effect of growth temperature on the microstructure SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 35th International Conference on Metallurgical Coatings and Thin Films CY APR 28-MAY 02, 2008 CL San Diego, CA SP Amer Vacuum Soc, Adv Surf Engn Div DE Nanocomposite coating; Lubrication; Solid lubricant; High-temperature lubrication; CrN-Ag ID YTTRIA-STABILIZED ZIRCONIA; SURFACE MORPHOLOGICAL EVOLUTION; TRIBOLOGICAL PROPERTIES; FILMS; DEPOSITION; FRICTION; MGO(001); BEHAVIOR; CRALN; GOLD AB CrN-Ag composite layers, 5-mu m-thick and containing 22 at.% Ag, were co-deposited by reactive magnetron sputtering on Si(001) substrates in a 0.4 Pa pure nitrogen atmosphere at growth temperatures T(s)=500, 600, and 700 degrees C. A combination of X-ray diffraction and cross-sectional microscopy analyses show that Ag segregates to form precipitates with an average size that increases from < 25 nm to similar to 300x300x 100 nm(3) to similar to 600x600x200 nm(3) for T(s) = 500, 600, and 700 degrees C respectively. At high T(s) the precipitates extend along the surface plane to form horizontal lamellae that cause grain re-nucleation and, in turn, a disruption of the columnar microstructure and a transition from a strong 002 texture for pure CrN to a mixed preferred orientation for the composite coatings. In addition, Ag segregates to form mounds on the growing layer surface that result in the nucleation of nodules which exhibit an increased growth rate and extend up to I and 5 mu m above the surface for T(s)=600 and 700 degrees C, respectively, but are absent for T(s)=500 degrees C. The cross-sectional microhardness increases with T(s) from 17 to 20 to 24 GPa for T(s)=500, 600, and 700 degrees C, respectively, which is attributed to a decrease in the effective Ag concentration associated with temperature-activated segregation. The measured hardness for pure CrN is 28 GPa. (c) 2008 Elsevier B.V. All rights reserved. C1 [Mulligan, C. P.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Blanchet, T. A.] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. [Mulligan, C. P.] USA, Armament Res & Dev Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Gall, D (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. EM galld@rpi.edu RI Gall, Daniel/B-1060-2008 OI Gall, Daniel/0000-0002-5762-9307 NR 23 TC 32 Z9 35 U1 3 U2 13 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD DEC 25 PY 2008 VL 203 IS 5-7 BP 584 EP 587 DI 10.1016/j.surfcoat.2008.06.052 PG 4 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 383DK UT WOS:000261654100038 ER PT J AU Pappas, DD Bujanda, AA Orlicki, JA Jensen, RE AF Pappas, D. Daphne Bujanda, Andres A. Orlicki, Joshua A. Jensen, Robert E. TI Chemical and morphological modification of polymers under a helium-oxygen dielectric barrier discharge SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 35th International Conference on Metallurgical Coatings and Thin Films CY APR 28-MAY 02, 2008 CL San Diego, CA SP Amer Vacuum Soc, Adv Surf Engn Div DE Dialectric barrier discharge; Polymers; XPS; SEM; Wettability ID SURFACE OXIDATION AB In this work, the surface modifications of various polymer films due to helium-oxygen dielectric barrier discharge (DBD) exposure operating under atmospheric pressure are reported. The polymer films studied include ultra high molecular weight polyethylene, polyamide, polytetrafluoroethylene and polyimide. Experimental results reveal increased hydrophilicity and surface energy of the plasma exposed polymers. This is attributed to the presence of oxygen containing groups grafted onto the surface during plasma treatment, as confirmed by X-ray photoelectron spectroscopy (XPS) analysis. Scanning electron microscopy (SEM) data show the appearance of micro depressions, the size of which depends on the chemical structure and the treatment time, suggesting that mild etching occurs in a predicted fashion. Most importantly, this uniform modification occurs within a few seconds of exposure, time comparable to continuous on-line industrial processing. Published by Elsevier B.V. C1 [Pappas, D. Daphne; Bujanda, Andres A.; Orlicki, Joshua A.; Jensen, Robert E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pappas, DD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM daphne.pappas@us.army.mil OI Pappas, Daphne/0000-0002-5746-8873 NR 15 TC 24 Z9 25 U1 1 U2 5 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD DEC 25 PY 2008 VL 203 IS 5-7 BP 830 EP 834 DI 10.1016/j.surfcoat.2008.05.029 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 383DK UT WOS:000261654100090 ER PT J AU Illick, MM Branco, LM Fair, JN Illick, KA Matschiner, A Schoepp, R Garry, RF Guttieri, MC AF Illick, Megan M. Branco, Luis M. Fair, Joseph N. Illick, Kerry A. Matschiner, Alex Schoepp, Randal Garry, Robert F. Guttieri, Mary C. TI Uncoupling GP1 and GP2 expression in the Lassa virus glycoprotein complex: implications for GP1 ectodomain shedding SO VIROLOGY JOURNAL LA English DT Article ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; STABLE SIGNAL PEPTIDE; EBOLA-VIRUS; MONOCLONAL-ANTIBODIES; FEVER; IDENTIFICATION; INFECTION; PROTEINS; VECTORS; SYSTEMS AB Background: Sera from convalescent Lassa fever patients often contains antibodies to Lassa virus (LASV) glycoprotein 1 (GP1), and glycoprotein 2 (GP2); Immunization of non-human primates with viral vectors expressing the arenaviral glycoprotein complex (GPC) confers full protective immunity against a lethal challenge with LASV. Thus, the development of native or quasi native recombinant LASV GP1 and GP2 as soluble, uncoupled proteins will improve current diagnostics, treatment, and prevention of Lassa fever. To this end, mammalian expression systems were engineered for production and purification of secreted forms of soluble LASV GP1 and GP2 proteins. Results: Determinants for mammalian cell expression of secreted uncoupled Lassa virus (LASV) glycoprotein 1 (GP1) and glycoprotein 2 (GP2) were established. Soluble GP1 was generated using either the native glycoprotein precursor (GPC) signal peptide (SP) or human IgG signal sequences (s.s.). GP2 was secreted from cells only when (1) the transmembrane (TM) domain was deleted, the intracellular domain (IC) was fused to the ectodomain, and the gene was co-expressed with a complete GP1 gene in cis; (2) the TM and IC domains were deleted and GP1 was co-expressed in cis; (3) expression of GP1 was driven by the native GPC SP. These data implicate GP1 as a chaperone for processing and shuttling GP2 to the cell surface. The soluble forms of GP1 and GP2 generated through these studies were secreted as homogeneously glycosylated proteins that contained high mannose glycans. Furthermore, observation of GP1 ectodomain shedding from cells expressing wild type LASV GPC represents a novel aspect of arenaviral glycoprotein expression. Conclusion: These results implicate GP1 as a chaperone for the correct processing and shuttling of GP2 to the cell surface, and suggest that native GPC SP plays a role in this process. In the absence of GP1 and GPC SP the GP2 protein may be processed by an alternate pathway that produces heterogeneously glycosylated protein, or the polypeptide may not fully mature in the secretory cascade in mammalian cells. The expression constructs developed in these studies resulted in the generation and purification of soluble, uncoupled GP1 and GP2 proteins from mammalian cells with quasinative properties. The observation of GP1 ectodomain shedding from cells expressing wild type LASV GPC establishes new correlates of disease progression and highlights potential opportunities for development of diagnostics targeting the early stages of Lassa fever. C1 [Branco, Luis M.; Fair, Joseph N.; Garry, Robert F.] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. [Illick, Megan M.; Illick, Kerry A.; Matschiner, Alex] BioFactura Inc, Rockville, MD USA. [Fair, Joseph N.] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA 70118 USA. [Fair, Joseph N.; Guttieri, Mary C.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Illick, Kerry A.] Cedar Crest Muhlenberg Coll, Dept Sci, Allentown, PA 18104 USA. [Schoepp, Randal] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Garry, RF (reprint author), Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. EM millick@biofactura.com; lbranco@tulane.edu; fair@southernresearch.org; kaillick@cedarcrest.edu; amatschiner@biofactura.com; randal.schoepp@amedd.army.mil; rfgarry@tulane.edu; marycguttieri@aol.com RI Valle, Ruben/A-7512-2013 FU NIAID NIH HHS [1 UC1 AI067188-01, UC1 AI067188] NR 31 TC 10 Z9 10 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD DEC 23 PY 2008 VL 5 AR 161 DI 10.1186/1743-422X-5-161 PG 17 WC Virology SC Virology GA 414CA UT WOS:000263840300001 PM 19105844 ER PT J AU Lim, W Douglas, EA Kim, SH Norton, DP Pearton, SJ Ren, F Shen, H Chang, WH AF Lim, Wantae Douglas, E. A. Kim, S.-H. Norton, D. P. Pearton, S. J. Ren, F. Shen, H. Chang, W. H. TI Low-temperature-fabricated InGaZnO4 thin film transistors on polyimide clean-room tape SO APPLIED PHYSICS LETTERS LA English DT Article DE carrier density; carrier mobility; flexible electronics; gallium compounds; indium compounds; polymers; semiconductor growth; semiconductor thin films; sputter deposition; substrates; ternary semiconductors; thin film transistors; zinc compounds ID AMORPHOUS OXIDE SEMICONDUCTORS AB Amorphous (alpha-)InGaZnO4 thin film transistors (TFTs) were fabricated on polyimide clean-room tape at low temperature (< 100 degrees C). The alpha-InGaZnO4 films with an n-type carrier concentration of similar to 10(16) cm(-3) were deposited by rf-magnetron sputtering in a mixed ambient of Ar/O-2. The bottom-gate-type TFTs showed good saturation mobility (similar to 5.3 cm(2) V-1 s(-1)), drain current on-to-off ratio of approximately 10(5), threshold voltage of 1.1 V, and subthreshold gate-voltage swing of 0.55 V decade(-1). These results were comparable to those of the same oxide TFTs that we have fabricated on either glass or polyethylene terephthalate substrates. The results demonstrate that even polyimide clean-room tape can be an appropriate substrate for inexpensive-flexible-adhesive-transparent electronic devices. C1 [Lim, Wantae; Douglas, E. A.; Kim, S.-H.; Norton, D. P.; Pearton, S. J.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Ren, F.] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. [Shen, H.; Chang, W. H.] Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Lim, W (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Douglas, Erica/J-3732-2014 OI Douglas, Erica/0000-0003-1873-0223 NR 23 TC 34 Z9 35 U1 2 U2 13 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 22 PY 2008 VL 93 IS 25 AR 252103 DI 10.1063/1.3054167 PG 3 WC Physics, Applied SC Physics GA 388GQ UT WOS:000262008700023 ER PT J AU Cohen, SP Argoff, CE Carragee, EJ AF Cohen, Steven P. Argoff, Charles E. Carragee, Eugene J. TI Management of low back pain SO BRITISH MEDICAL JOURNAL LA English DT Review ID CLINICAL-PRACTICE GUIDELINE; PRIMARY-CARE; FACET JOINT; DIAGNOSIS; PHYSICIANS; IDENTIFY; THERAPY; COLLEGE; NECK C1 [Cohen, Steven P.] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Pain Management Div, Baltimore, MD 21205 USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Argoff, Charles E.] Albany Med Coll, Dept Neurol, Comprehens Pain Program, Albany, NY 12208 USA. [Carragee, Eugene J.] Stanford Univ, Sch Med, Dept Orthoped Surg, Div Spine Surg, Stanford, CA 94305 USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 23 TC 52 Z9 52 U1 1 U2 7 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0959-8146 J9 BRIT MED J JI Br. Med. J. PD DEC 22 PY 2008 VL 337 AR a2718 DI 10.1136/bmj.a2718 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA 394EI UT WOS:000262428100001 PM 19103627 ER PT J AU Folkes, PA AF Folkes, Patrick A. TI Interband cascade laser photon noise SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article ID INTENSITY FLUCTUATIONS; SEMICONDUCTOR-LASERS; QUANTUM-WELLS; MODEL AB We report measurements of the low-frequency photon noise and the relative intensity noise of an interband cascade laser as a function of laser current at 30 and 100 K. Away from threshold, the laser primarily exhibits a frequency-independent photon noise spectral density in agreement with theory. At threshold, the observed photon noise spectral density exhibits large fluctuations at closely spaced discrete frequencies. Thermal effects at 100 K result in a large increase in the photon noise above threshold. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Folkes, PA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 27 TC 2 Z9 2 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0022-3727 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD DEC 21 PY 2008 VL 41 IS 24 AR 245109 DI 10.1088/0022-3727/41/24/245109 PG 4 WC Physics, Applied SC Physics GA 379GC UT WOS:000261383700016 ER PT J AU Grujicic, M Arakere, G He, T Bell, WC Cheeseman, BA Yen, CF Scott, B AF Grujicic, M. Arakere, G. He, T. Bell, W. C. Cheeseman, B. A. Yen, C. -F. Scott, B. TI A ballistic material model for cross-plied unidirectional ultra-high molecular-weight polyethylene fiber-reinforced armor-grade composites SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Flexible armor; Armor-grade composites; Material model; High-performance fibers; Ballistic performance ID LAMINATED KEVLAR; IMPACT; PENETRATION; PROJECTILES; MECHANISMS; FAILURE; EPOXY AB The known fiber and polymeric-matrix material properties, unit-cell microstructural characteristics and unit-cell level finite-element analyses are used to construct a new ballistic material model for 0 degrees/90 degrees crossplied oriented polyethylene fiber-based armor-grade composite laminates. The model is constructed in such a way that it can be readily integrated into commercial finite-element programs like ANSYS/Autodyn [ANSYS/Autodyn version 11.0, User Documentation, Century Dynamics Inc., a subsidiary of ANSYS Inc., 20071 and ABAQUS/Explicit [ABAQUS version 6.7, User Documentation, Dessault Systems, 2007] as a user material subroutine. To validate the model, a series of transient non-linear dynamics simulations of the transverse impact of armor-grade composite laminates with two types of bullets/projectiles is carried out. The results obtained are next compared with their experimental counterparts. This comparison revealed that a relatively good agreement is obtained between the experimental and the computational analysis relative to: (a) the success of the armor panels of different areal densities in defeating the bullets at different initial bullet velocities; (b) post-mortem spatial distribution of damage within the panels; (c) the temporal evolution of a bulge at the back-face of the armor; and (d) the existence of three distinct armor-penetration stages (i.e. an initial filament shearing/cutting dominated stage, an intermediate stage characterized by pronounced filament/matrix de-bonding/decohesion and the final stage associated with the extensive bulging of the armor panel). (C) 2008 Elsevier B.V. All rights reserved. C1 [Grujicic, M.; Arakere, G.; He, T.; Bell, W. C.] Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.; Yen, C. -F.; Scott, B.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U.S. Army/Clemson University [W911 NF-04-2-0024, W911 NF-06-2-0042] FX The material presented in this paper is based on work supported by the U.S. Army/Clemson University Cooperative Agreements W911 NF-04-2-0024 and W911 NF-06-2-0042. NR 36 TC 45 Z9 47 U1 2 U2 23 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD DEC 20 PY 2008 VL 498 IS 1-2 SI SI BP 231 EP 241 DI 10.1016/j.msea.2008.07.056 PG 11 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 379UA UT WOS:000261420500033 ER PT J AU Taylor, WRJ Widjaja, H Basri, H Ohrt, C Taufik, T Tjitra, E Baso, S Fryauff, D Hoffman, SL Richie, TL AF Taylor, Walter R. J. Widjaja, Hendra Basri, Hasan Ohrt, Colin Taufik, Taufik Tjitra, Emiliana Baso, Samuel Fryauff, David Hoffman, Stephen L. Richie, Thomas L. TI Changes in the total leukocyte and platelet counts in Papuan and non Papuan adults from northeast Papua infected with acute Plasmodium vivax or uncomplicated Plasmodium falciparum malaria SO MALARIA JOURNAL LA English DT Article ID CLINICAL-FEATURES; PERIPHERAL-BLOOD; GAMBIAN CHILDREN; IMPORTED MALARIA; IRIAN-JAYA; THROMBOCYTOPENIA; COMBINATION; MECHANISMS; INDONESIA; SOLDIERS AB Background: There are limited data on the evolution of the leukocyte and platelet counts in malaria patients. Methods: In a clinical trial of chloroquine vs. chloroquine plus doxycycline vs. doxycycline alone against Plasmodium vivax (n = 64) or Plasmodium falciparum (n = 98) malaria, the total white cell (WCC) and platelet (PLT) counts were measured on Days 0, 3, 7 and 28 in 57 indigenous Papuans with life long malaria exposure and 105 non Papuan immigrants from other parts of Indonesia with limited malaria exposure. Results: The mean Day 0 WCC (n = 152) was 6.492 (range 2.1-13.4) x 10(9)/L and was significantly lower in the Papuans compared to the non Papuans: 5.77 x 10(9)/L vs. 6.86 x 10(9)/L, difference = -1.09 [(95% CI -0.42 to -1.79 x 10(9)/L), P = 0.0018]. 14 (9.2%) and 9 (5.9%) patients had leukopaenia (<4.0 x 10(9)/L) and leukocytosis (>10.0 x 10(9)/L), respectively. By Day 28, the mean WCC increased significantly (P = 0.0003) from 6.37 to 7.47 x 10(9)/L (73 paired values) and was similar between the two groups. Ethnicity was the only WCC explanatory factor and only on Day 0. The mean Day 0 platelet count (n = 151) was 113.0 (range 8.0-313.0) x 10(9)/L and rose significantly to 186.308 x 10(9)/L by Day 28 (P < 0.0001). There was a corresponding fall in patient proportions with thrombocytopaenia (< 150 x 10(9)/L): 119/151 (78.81%) vs. 16/73 (21.92%, P < 0.00001). Papuan and non Papuan mean platelet counts were similar at all time points. Only malaria species on Day 0 was a significant platelet count explanatory factor. The mean D0 platelet counts were significantly lower (P = 0.025) in vivax (102.022 x 10(9)/L) vs. falciparum (122.125 x 10(9)/L) patients. Conclusion: Changes in leukocytes and platelets were consistent with other malaria studies. The Papuan non Papuan difference in the mean Day 0 WCC was small but might be related to the difference in malaria exposure. C1 [Taylor, Walter R. J.; Widjaja, Hendra; Basri, Hasan; Fryauff, David; Richie, Thomas L.] US Navy Med Res Unit 2, Jakarta, Indonesia. [Taylor, Walter R. J.] Tulane Univ, Sch Publ Hlth, Dept Trop Med, New Orleans, LA 70118 USA. [Ohrt, Colin] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. [Taufik, Taufik] Indonesian Naval Hosp, Jayapura, Papua, Indonesia. [Tjitra, Emiliana] Natl Inst Hlth, Ctr Hlth Res & Dev, Jakarta, Indonesia. [Baso, Samuel] Rumah Sakit Umum, Jayapura, Papua, Indonesia. [Hoffman, Stephen L.] USN, Med Res Ctr, Bethesda, MD USA. RP Taylor, WRJ (reprint author), US Navy Med Res Unit 2, Jakarta, Indonesia. EM btaylor@oucru.org; Hwidjaja@fhi.or.id; Hbasri@fhi.or.id; Cohrt@wrair.mil.gov; Taufik@yahoo.com; emilt@litbang.depkes.go.id; Sbaso@yahoo.com; FryauffD@NMRC.NAVY.MIL; slhoffman@sanaria.com; RichieT@NMRC.NAVY.MIL OI Richie, Thomas/0000-0002-2946-5456 FU US Naval Medical Research and Development Command [DoD 63002A M00101 HEX 2406] FX This study was funded by the US Naval Medical Research and Development Command (DoD 63002A M00101 HEX 2406) NR 45 TC 14 Z9 15 U1 0 U2 0 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 18 PY 2008 VL 7 AR 259 DI 10.1186/1475-2875-7-259 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 409ZI UT WOS:000263543900001 PM 19094197 ER PT J AU Ramkumar, SS Love, AH Sata, UR Koester, CJ Smith, WJ Keating, GA Hobbs, LW Cox, SB Lagna, WM Kendall, RJ AF Ramkumar, Seshadri S. Love, Adam H. Sata, Utkarsh R. Koester, Carolyn J. Smith, William J. Keating, Garrett A. Hobbs, Lawrence W. Cox, Stephen B. Lagna, William M. Kendall, Ronald J. TI Next-Generation Nonparticulate Dry Nonwoven Pad for Chemical Warfare Agent Decontamination SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID CARBON FABRICS AB New, nonparticulate decontamination materials promise to reduce both military and civilian casualties by enabling individuals to decontaminate themselves and their equipment within minutes of exposure to chemical warfare agents or other toxic materials. One of the most promising decontaminating materials has been developed using a needle-punching nonwoven process to construct a nonparticulate composite fabric of multiple layers, including an inner layer of activated carbon fabric, which is well-suited for the decontamination of both personnel and equipment. This paper describes the development of a composite nonwoven pad and compares efficacy test results for this pad with results from testing other decontamination systems. The efficacy of the dry nonwoven fabric pad was demonstrated specifically for decontamination of the chemical warfare blister agent bis(2-chloroethyl)sulfide (HD or sulfur mustard). Gas chromatography/mass spectroscopy (GC/MS) results indicate that the composite fabric was capable of significantly reducing the vapor hazard from mustard liquid absorbed into the nonwoven dry fabric pad. The mustard adsorption efficiency of the nonwoven pad was significantly higher than that of particulate activated carbon and was similar to the currently fielded U.S. military M291 kit. The nonwoven pad has several advantages over other materials, especially its nonparticulate, yet flexible, construction. This composite fabric was also shown to be chemically compatible with potential toxic and hazardous liquids, which span a range of hydrophilic and hydrophobic chemicals, including a concentrated acid, an organic solvent, and a mild oxidant (bleach). C1 [Ramkumar, Seshadri S.; Sata, Utkarsh R.; Cox, Stephen B.; Kendall, Ronald J.] Texas Tech Univ, Inst Environm & Human Hlth, Lubbock, TX 79409 USA. [Love, Adam H.; Koester, Carolyn J.; Smith, William J.; Keating, Garrett A.] Lawrence Livermore Natl Lab, Forens Sci Ctr, Livermore, CA 94550 USA. [Hobbs, Lawrence W.] Hobbs Bonded Fibers, Waco, TX 76710 USA. [Lagna, William M.] USA, Edgewood Chem Biol Ctr, Res Dev & Engn Command, AMSRD ECB RT D, Aberdeen Proving Ground, MD 21010 USA. RP Ramkumar, SS (reprint author), Texas Tech Univ, Inst Environm & Human Hlth, Lubbock, TX 79409 USA. EM s.ramkumar@ttu.edu RI Cox, Stephen/A-5037-2010 FU U.S. Department of Energy by University of California; Lawrence Livermore National Laboratory [W-7405-Eng-48]; Food and Fibers Research Grant Program of Texas FX The evaluation of this composite wipe was part of a DHS-funded project, managed by the Technical Support Working Group (TSWG), to develop a Low-Cost Personal Decontamination System. The project was performed under the auspices of the U.S. Department of Energy by University of California, Lawrence Livermore National Laboratory (under Contract W-7405-Eng-48). S.R. gratefully acknowledges the U.S. Army Research, the Development and Engineering Command of the U.S. Department of Defense, for broad-based support of his research on nonwoven fabrics for personal protection and decontamination. S.R. also acknowledges the Food and Fibers Research Grant Program of Texas, The CH Foundation of Lubbock, Cotton Foundation, South Plains Foundation, Lubbock, ICRC of CASNR-TTU and Plains Cotton Growers, Inc. for supporting his nonwovens research at Texas Tech University. Garfield Purdon and Andrew Burczyk of Defence Research and Development Canada-Suffield, Philip O'Dell of O'Dell Engineering, and Nayla Feghali of E-Z-EM, Inc., provided valuable insights into the design and performance requirements for the dry pad. NR 23 TC 7 Z9 7 U1 1 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD DEC 17 PY 2008 VL 47 IS 24 BP 9889 EP 9895 DI 10.1021/ie801223b PG 7 WC Engineering, Chemical SC Engineering GA 382TU UT WOS:000261629100011 ER PT J AU He, H Pandey, R Karna, SP AF He, Haiying Pandey, Ravindra Karna, Shashi P. TI Electronic conduction in a model three-terminal molecular transistor SO NANOTECHNOLOGY LA English DT Article ID NEGATIVE DIFFERENTIAL RESISTANCE; CARBON NANOTUBE; SINGLE; TRANSPORT; DENSITY; WIRES AB The electronic conduction of a novel, three-terminal molecular architecture, analogous to a heterojunction bipolar transistor, is studied. In this architecture, two diode arms consisting of donor-acceptor molecular wires fuse through a ring, while a gate modulating wire is a pi-conjugated wire. The calculated results show the enhancement or depletion mode of a transistor on applying a gate field along the positive or negative direction. A small gate field is required to switch on the current in the proposed architecture. The changes in the electronic conduction can be attributed to the intrinsic dipolar molecular architecture in terms of the evolution of molecular wavefunctions, specifically the one associated with the terphenyl group of the modulating wire in the presence of the gate field. C1 [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Multi Scale Technol Inst, Houghton, MI 49931 USA. [Karna, Shashi P.] USA, Res Lab, Weapons & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; skarna@arl.army.mil OI He, Haiying/0000-0002-3493-2784 FU DARPA [ARL-DAAD17-03-C-0115]; ARL-Director's Research [FY05-WMR01] FX The work at Michigan Technological University was performed under support by the DARPA through contract number ARL-DAAD17-03-C-0115. The work at Army Research Laboratory (ARL) was supported by the DARPA MoleApps program and ARL-Director's Research Initiative-FY05-WMR01. Helpful discussions with G Mallick, S Gowtham, K C Lau and R Pati are gratefully acknowledged. NR 31 TC 10 Z9 10 U1 0 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0957-4484 J9 NANOTECHNOLOGY JI Nanotechnology PD DEC 17 PY 2008 VL 19 IS 50 AR 505203 DI 10.1088/0957-4484/19/50/505203 PG 6 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 376TK UT WOS:000261205700007 PM 19942764 ER PT J AU Anderson, GP Liu, JL Hale, ML Bernstein, RD Moore, M Swain, MD Goldman, ER AF Anderson, George P. Liu, Jinny L. Hale, Martha L. Bernstein, Rachael D. Moore, Martin Swain, Maria D. Goldman, Ellen R. TI Development of Antiricin Single Domain Antibodies Toward Detection and Therapeutic Reagents SO ANALYTICAL CHEMISTRY LA English DT Article ID RICIN; FRAGMENTS; BIOSENSOR; IDENTIFICATION; EXPRESSION; STABILITY; SELECTION; PROTEINS; SEQUENCE; ANTIGEN AB Single domain antibodies (sdAb) that bind ricin with high affinity and specificity were selected from a phage display library derived from the mRNA of heavy chain antibodies obtained from lymphocytes of immunized llamas. The sdAb were found to recognize three distinct epitopes on ricin. Representative sdAb were demonstrated to function as both capture and tracer elements in fluid array immunoassays, a limit of detection of 1.6 ng/mL was obtained. One sdAb pair in particular was found to be highly specific for ricin. While polyclonal antibodies cross react strongly with RCA120, the sdAb pair had minimal cross reactivity. In addition, the binders were found to be thermal stable, regaining their ricin binding activity following heating to 85 T for an hour. Cycles of thermally induced unfolding of the sdAb and their subsequent refolding upon cooling was monitored by circular dichroism. As several of the sdAb were observed to bind to ricin's A chain, cell free translation assays were performed to monitor the ability of the sdAbs to inhibit ricin's biological activity. One of the sdAb (C8) was particularly effective and blocked ricin's biological activity with an effectiveness equal to that of a mouse antiricin antibody. These results indicate that antiricin sdAb have great potential for both diagnostic and therapeutic applications. C1 [Anderson, George P.; Liu, Jinny L.; Moore, Martin; Swain, Maria D.; Goldman, Ellen R.] USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. [Hale, Martha L.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD 21702 USA. [Bernstein, Rachael D.] Nova Res Inc, Alexandria, VA 22308 USA. RP Goldman, ER (reprint author), USN, Res Lab, Ctr Biomol Sci & Engn, 4555 Overlook Ave SW, Washington, DC 20375 USA. EM ellen.goldman@nrl.navy.mil RI Anderson, George/D-2461-2011 OI Anderson, George/0000-0001-7545-9893 FU JSTO-CBD/DTRA; U.S. Navy, the U.S. Department of Defense, or the U.S. government FX This work was supported by JSTO-CBD/DTRA. The opinions expressed here are those of the authors and do not represent those of the U.S. Navy, the U.S. Department of Defense, or the U.S. government. NR 33 TC 35 Z9 35 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD DEC 15 PY 2008 VL 80 IS 24 BP 9604 EP 9611 DI 10.1021/ac8019398 PG 8 WC Chemistry, Analytical SC Chemistry GA 384FE UT WOS:000261728900029 PM 19072267 ER PT J AU Chen, XJJ West, AC Cropek, DM Banta, S AF Chen, Xiaojun J. West, Alan C. Cropek, Donald M. Banta, Scott TI Detection of the Superoxide Radical Anion Using Various Alkanethiol Monolayers and Immobilized Cytochrome c SO ANALYTICAL CHEMISTRY LA English DT Article ID SELF-ASSEMBLED MONOLAYER; 3RD-GENERATION BIOSENSOR; NITRIC-OXIDE; DISMUTASE; ELECTRODES; REPERFUSION; ISCHEMIA; COPPER AB The superoxide radical anion (SO) is a critical biomarker for monitoring cellular stress responses. Electrochemical SO biosensors are frequently constructed through the covalent immobilization of cytochrome c (Cyt c) onto self-assembled monolayers (SAMs); however, a detailed comparison of these systems as well as configuration influence on SO detection is needed to enable robust applications. Two reaction pathways, oxidation of SO by the SAM-modified gold electrode or electron transfer through a protein and monolayer relay, may be involved during the electrochemical detection of SO with Cyt c, depending on the SAM that is used. Although electrodes with SAMs alone can exhibit a high sensitivity and low limit of detection (LOD) for the SO, they can suffer from a strong response to the presence of interferents such as hydrogen peroxide and ascorbic acid. Electrodes with immobilized Cyt c show decreased sensitivity, but exhibit better selectivity and resistance to fouling in complex media. Considering the trade-offs between sensitivity, selectivity, and LOD for SO detection, a bioelectrode made with Cyt c immobilized on dithiobis(succinimidyl)propionate (DISP) appears to be the most suitable configuration. In phosphate buffer, the DTSP/Cyt c electrode has a sensitivity of 410 nA mu M(-1) cm(-1) and an LOD for SO of 73 nM. Results are also presented for the detection of SO in a complex tissue culture media (MEM) with and without serum, and the sensitivity of the DTSP/Cyt c in MEM in the absence of serum increased to 640 nA mu M(-1) cm(-1). By measuring SO with a DTSP/Cyt c electrode before and after the addition of a bolus of the superoxide dismutase (SOD) enzyme, the specificity of the SOD enzyme can be combined with the sensitivity of Cyt c system. C1 [Chen, Xiaojun J.; West, Alan C.; Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. [Chen, Xiaojun J.; Cropek, Donald M.] USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Banta, S (reprint author), Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. EM sbanta@cheme.columbia.edu FU U.S: Army Applied Research FX This research was supported by the U.S: Army Applied Research Program. We thank Lt. Col. Robert Bozic for helpful discussions and assistance. NR 32 TC 37 Z9 37 U1 3 U2 38 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD DEC 15 PY 2008 VL 80 IS 24 BP 9622 EP 9629 DI 10.1021/ac800796b PG 8 WC Chemistry, Analytical SC Chemistry GA 384FE UT WOS:000261728900031 PM 19072268 ER PT J AU Alhamadsheh, MM Waters, NC Sachdeva, S Lee, P Reynolds, KA AF Alhamadsheh, Mamoun M. Waters, Norman C. Sachdeva, Sarbjot Lee, Patricia Reynolds, Kevin A. TI Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE FabH; Fatty acid biosynthesis; SAR; Plasmodium falciparum; Inhibition ID PROTEIN SYNTHASE-III; FATTY-ACID BIOSYNTHESIS; MYCOBACTERIUM-TUBERCULOSIS; CRYSTAL-STRUCTURE; DISCOVERY AB A series of analogs of 2-tosylnaphthalene-1,4-diol were prepared and were found to be potent 10-20 nM reversible inhibitors of the Escherichia coli FabH enzyme. The inhibitors were also effective but to a lesser degree (30 nM-5 mu M), against the Mycobacterium tuberculosis and Plasmodium falciparum FabH enzymes. Preliminary SAR studies demonstrated that the sulfonyl group and naphthalene-1,4 diol were required for activity against all enzymes but the toluene portion could be significantly altered and leads to either modest increases or decreases in activity against the three enzymes. The in vitro activity of the analogs against E. coli FabH parallel the in vivo activity against E. coli TolC strain and many of the compounds were also shown to have antimalarial activity against P. falciparum. (C) 2008 Published by Elsevier Ltd. C1 [Alhamadsheh, Mamoun M.; Sachdeva, Sarbjot; Reynolds, Kevin A.] Portland State Univ, Dept Chem, Portland, OR 97207 USA. [Waters, Norman C.; Lee, Patricia] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Reynolds, KA (reprint author), Portland State Univ, Dept Chem, Portland, OR 97207 USA. EM reynoldsk@pdx.edu OI Reynolds, Kevin/0000-0003-0270-9809 FU National Institutes of Health [AI52230] FX Funding for this research was generously provided by the National Institutes of Health (AI52230). We thank Dr Martin Smilkstein (Portland Veterans Affairs Medical Center) for performing the in vitro antimalarial assay. NR 16 TC 24 Z9 24 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD DEC 15 PY 2008 VL 18 IS 24 BP 6402 EP 6405 DI 10.1016/j.bmcl.2008.10.097 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 375VE UT WOS:000261141100022 PM 18996691 ER PT J AU Hashisho, Z Emamipour, H Rood, MJ Hay, KJ Kim, BJ Thurston, D AF Hashisho, Zaher Emamipour, Hamidreza Rood, Mark J. Hay, K. James Kim, Byung J. Thurston, Deborah TI Concomitant Adsorption and Desorption of Organic Vapor in Dry and Humid Air Streams using Microwave and Direct Electrothermal Swing Adsorption SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID CARBON LOAD EQUALIZATION; ACTIVATED CARBON; BIOFILTRATION; TOLUENE; CLOTH; BIOFILTER; REMOVAL; CAPTURE AB Industrial gas streams can contain highly variable organic vapor concentrations that need to be processed before they are emitted to the atmosphere. Fluctuations in organic vapor concentrations make it more difficult to operate a biofilter when compared to a constant vapor concentration. Hence, there is a need to stabilize the concentration of rapidly fluctuating gas streams for optimum operation of biofilters. This paper describes new concomitant adsorption desorption (CAD) systems used with variable organic vapor concentration gas streams to provide the same gas stream, but at a user-selected constant vapor concentration that can then be more readily processed by a secondary air pollution control device such as a biofilter. The systems adsorb organic vapor from gas streams and simultaneously heat the adsorbent using microwave or direct electrothermal energy to desorb the organic vapor at a user-selected set-point concentration. Both systems depicted a high degree of concentration stabilization with a mean relative deviation between set-point and stabilized concentration of 0.3-0.4%. The direct electrothermal CAD system was also evaluated to treat a humid gas stream (relative humidity = 85%) that contained a variable organic vapor concentration. The high humidity did not interfere with CAD operation as water vapor did not adsorb but penetrated through the adsorbent These results are important because they demonstrate the ability of CAD to effectively dampen concentration fluctuation in gas streams. C1 [Hashisho, Zaher] Univ Alberta, Dept Civil & Environm Engn, Edmonton, AB T6G 2W2, Canada. [Emamipour, Hamidreza; Rood, Mark J.; Thurston, Deborah] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Hay, K. James; Kim, Byung J.] USA, Construct Engn Res Lab, Ctr Res Dev & Engn, Champaign, IL 61826 USA. RP Hashisho, Z (reprint author), Univ Alberta, Dept Civil & Environm Engn, Edmonton, AB T6G 2W2, Canada. EM hashisho@ualberta.ca FU Department of Defense [W9132T-04-2-0006, A5639 FA8651-04-1-0004]; National Science Foundation [DMI-02-17491, BES-05-04385] FX Financial support is acknowledged from the Department of Defense under contracts W9132T-04-2-0006 and A5639 FA8651-04-1-0004, and from the National Science Foundation grants DMI-02-17491 and BES-05-04385. NR 23 TC 16 Z9 16 U1 1 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD DEC 15 PY 2008 VL 42 IS 24 BP 9317 EP 9322 DI 10.1021/es801285v PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 383MX UT WOS:000261678800052 PM 19174910 ER PT J AU Qin, WD Li, J Kou, H Gu, X Kecskes, L Chang, H Zhou, L AF Qin, Weidong Li, Jinshan Kou, Hongchao Gu, Xiaofeng Kecskes, Laszlo Chang, Hui Zhou, Lian TI Effects of Zn addition on the improvement of glass forming ability and plasticity of Mg-Cu-Tb bulk metallic glasses SO JOURNAL OF NON-CRYSTALLINE SOLIDS LA English DT Article DE Alloys; Glass formation ID ALLOYS; COMPOSITES; TRANSITION; VISCOSITY; STRENGTH; LIQUIDS; GD AB The effects of Zn addition on the glass forming ability and mechanical properties of Mg(65)Cu(25-x)Zn(x)Tb(10) (x = 0, 2.5, 5, and 7.5) have been investigated. We show that small amounts of Zn addition improve the glass forming ability, strength, and ductility of the Mg-Cu-Tb bulk metallic glass. For the best glass forming composition, amorphous rods of Mg(65)Cu(20)Zn(5)Tb(10) with a diameter of at least 7 mm have been prepared by a conventional copper mold casting method. Additionally, this composition exhibits obvious yielding and plastic deformation upon quasi-static compressive loading. The fracture strength. total strain to failure, and the plastic strain of the Mg(65)Cu(20)Zn(5)Tb(10) bulk metallic glass reaches 1025 MPa, 2.05% and 0.15%, respectively. This is significantly superior compared to that exhibited by the original Zn-free Mg-Cu-Tb amorphous alloy. (C) 2008 Elsevier B.V. All rights reserved. C1 [Qin, Weidong; Li, Jinshan; Kou, Hongchao; Chang, Hui; Zhou, Lian] NW Polytech Univ, State Key Lab Solidificat Proc, Xian 710072, Peoples R China. [Gu, Xiaofeng] Jiangnan Univ, Sch Informat Technol, Wuxi 214122, Jiangsu, Peoples R China. [Kecskes, Laszlo] USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Qin, WD (reprint author), NW Polytech Univ, State Key Lab Solidificat Proc, 127 Youyixi Road, Xian 710072, Peoples R China. EM qinweidong2000@yahoo.com.cn RI Gu, Xiaofeng/E-8287-2013; Kecskes, Laszlo/F-6880-2014; OI Gu, Xiaofeng/0000-0001-8299-6451; Kecskes, Laszlo/0000-0002-1342-3729; KOU, Hongchao/0000-0003-4960-9477; Li, Jinshan/0000-0002-6894-9760 FU National Natural Science Foundation of China [50601011, 50432020]; Fundamental Research Project of National Defense of China [A 2720060295]; NSF of Jiangsu Province Program for NCETs in University and Science [BK2006533]; DPOP in Northwestern Polytechnical University FX This work is supported by National Natural Science Foundation of China (Nos. 50601011, 50432020), Fundamental Research Project of National Defense of China (A 2720060295), NSF of Jiangsu Province (BK2006533), Program for NCETs in University and Science, and DPOP in Northwestern Polytechnical University. NR 26 TC 6 Z9 7 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3093 J9 J NON-CRYST SOLIDS JI J. Non-Cryst. Solids PD DEC 15 PY 2008 VL 354 IS 52-54 BP 5368 EP 5371 DI 10.1016/j.jnoncrysol.2008.09.032 PG 4 WC Materials Science, Ceramics; Materials Science, Multidisciplinary SC Materials Science GA 383YP UT WOS:000261710700005 ER PT J AU Bairavarasu, SR Edwards, ME Sastry, MD Kochary, F Kommidi, P Reddy, BR Lianos, D Aggarwal, MD AF Bairavarasu, Sundar R. Edwards, Matthew E. Sastry, Medury D. Kochary, Faris Kommidi, Praveena Reddy, B. Rami Lianos, Dimitrious Aggarwal, Manmohan D. TI Photomagnetism and photoluminescence (PL) of (Pb-Fe-e(-)) complex in lead magnesium niobate-lead titanate (PMN-PT) crystals containing beta-PbO nanoclusters SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY LA English DT Article DE PMN-PT; Photoluminescence; Magnetic polaron ID SINGLE-CRYSTALS; RESONANCE; TEMPERATURE; DEFECTS; EPR AB We present electron paramagnetic resonance (EPR)-evidence of photomagnetism under the conditions of in situ green laser illumination (photo-EPR) in lead magnesium niobate-lead titanate, Pb(Mg,Nb)O(3)-PbTiO(3) (PMN-PT), containing nanoparticles/wires of orthorhombic beta-PbO as identified by Raman spectroscopy. Photo-EPR studies of the sample containing beta-PbO, brownish red in color, have shown intense line at g=2.00, and its yield increased when produced in the presence of 7.5 kG external magnetic field suggesting the formation of magnetic polaron. This was identified as due to interaction between Fe(3+), photoinduced Pb(3+) and unpaired electron trapped at oxygen vacancies. The photoinduced growth and decay of magnetic polaron has shown a non-exponential behavior. Photoluminescence (PL) studies were conducted with excitation at 308 nm (XeCl laser) and also at 454.5,488 and 514.5 nm using At(+) laser. The excitation with 308 nm gave broad PL centered at 500 and 710 nm the latter being quite prominent in beta-PbO containing crystals, along with cooperative luminescence at 350 nm involving two emitting centers. The excitation with Ar(+) laser lines, close to the electronic absorption in samples containing beta-PbO gave richer and sharp PL emission in red region from the constituents of the magnetic polaron and also intense anti-Stokes emission on excitation with 514.5 nm radiation. This appears to be due to phototransfer optically stimulated luminescence (PT-OSL) involving electron-hole recombination at photoinduced magnetic polaron site. (C) 2008 Elsevier B.V. All rights reserved. C1 [Bairavarasu, Sundar R.; Edwards, Matthew E.; Sastry, Medury D.; Kochary, Faris; Kommidi, Praveena; Reddy, B. Rami; Aggarwal, Manmohan D.] Alabama A&M Univ, Dept Phys, Normal, AL 35762 USA. [Lianos, Dimitrious] USA, Space & Missile Def Command, Huntsville, AL 35805 USA. RP Bairavarasu, SR (reprint author), Alabama A&M Univ, Dept Phys, Normal, AL 35762 USA. EM sundarbairavarasu@gmail.com FU U.S. Army Missile and Defense [W9113M-04-C-0005]; HBCU-RISE National Science Foundation [HRD-0531183]; NASA Administrator's Fellowship Program (NAFP); United Negro College Fund Special Programs (UNCFSP)Corporation [NNG06GC58A] FX This work was supported by U.S. Army Missile and Defense contract #W9113M-04-C-0005 and HBCU-RISE National Science Foundation HRD-0531183 project. Authors wish to thank Dr. Josh Herring of the Department of Food Science, for his help with electron microscopy measurements. Thanks are also due to Sandesh Mane and Mahesh Gaonkar GII, Mumbai, for recording Raman and FT-IR spectra. One of the authors (MDA) would like to acknowledge the support from NASA Administrator's Fellowship Program (NAFP) through United Negro College Fund Special Programs (UNCFSP)Corporation under their contract #NNG06GC58A. NR 40 TC 2 Z9 2 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1386-1425 J9 SPECTROCHIM ACTA A JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. PD DEC 15 PY 2008 VL 71 IS 4 BP 1581 EP 1587 DI 10.1016/j.saa.2008.06.004 PG 7 WC Spectroscopy SC Spectroscopy GA 377KC UT WOS:000261249100068 PM 18644744 ER PT J AU Cardoso, MJ Dmitriev, AE Helgeson, M Lehman, RA Kuklo, TR Rosner, MK AF Cardoso, Mario J. Dmitriev, Anton E. Helgeson, Melvin Lehman, Ronald A. Kuklo, Timothy R. Rosner, Michael K. TI Does Superior-Segment Facet Violation or Laminectomy Destabilize the Adjacent Level in Lumbar Transpedicular Fixation? SO SPINE LA English DT Article DE Adjacent level disease; facet violation; laminectomy; transpedicular lumbar fixation ID PEDICLE SCREW FIXATION; INTERBODY FUSION; JOINT VIOLATION; SPINAL-FUSION; FOLLOW-UP; INSTRUMENTATION; COMPLICATIONS; DEGENERATION; INSTABILITY; SPONDYLOLISTHESIS AB Study Design. This is an in vitro biomechanical study. Objective. The current investigation was performed to evaluate adjacent level kinematic change following unilateral and bilateral facet violation and laminectomy following 1-, 2-, and 3-level reconstruction. Summary of Background Data. The incidence of superior-segment facet violation with lumbar transpedicular fixation has been reported as high as 35%; however, its contribution to biomechanical instability at the supradjacent level is unknown. In addition, superior-segment laminectomy has been implicated as a risk factor for the development of adjacent level disease. The authors assess the acute biomechanical effects of proximal facet violation and subsequent laminectomy in an instrumented posterior fusion model in 10 cadaveric specimens. Methods. Biomechanical testing was performed on 10 human cadaveric spines under axial rotation (AR), flexion-extension (FE), and lateral bending (LB) loading. After intact analysis, pedicle screws were inserted from L5-S1 and testing repeated with: (1) preserved L4-L5 facets, (2) unilateral facet breach, (3) bilateral breach, and (4) L5 laminectomy. Following biomechanical analysis, instrumentation was extended to L4, then L3 and biomechanical testing repeated. Full range of motion (ROM) at the proximal adjacent levels were recorded and normalized to intact (100%). Results. Supradjacent level ROM was increased for all groups under all loading methods relative to intact (P < 0.05). However, AR testing revealed progressive instability at the adjacent level in groups 3 and 4, relative to group 1, following 1-, 2- and 3-level fixation (P < 0.05). During FE, supradjacent level ROM was significantly increased for group 4 specimens compared with group 1 after L5-S1 fixation (P < 0.05), and was greater than all other groups for L3-S1 constructs (P < 0.05). Interestingly, under lateral bending, facet joint destabilization did not change adjacent segment ROM. Conclusion. There were significant changes in proximal level ROM immediately after posterior stabilization. However, an additional increase in supradjacent segment ROM was recorded during AR after bilateral facet breach. Subsequent complete laminectomy at the uppermost-fixation level further destabilized the supradjacent segment in FE and AR. Therefore, meticulous preservation of the cephalad-most segment facet joints-is paramount to ensure stability. C1 [Cardoso, Mario J.; Rosner, Michael K.] Walter Reed Army Med Ctr, Neurosurg Serv, Washington, DC 20307 USA. [Dmitriev, Anton E.; Helgeson, Melvin; Lehman, Ronald A.] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. [Kuklo, Timothy R.] WA Univ St Louis, Dept Orthoped Surg, St Louis, MO USA. RP Cardoso, MJ (reprint author), Walter Reed Army Med Ctr, Neurosurg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM mtcardoso@comcast.net NR 31 TC 31 Z9 39 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD DEC 15 PY 2008 VL 33 IS 26 BP 2868 EP 2873 DI 10.1097/BRS.0b013e31818c63d3 PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 405YT UT WOS:000263260800004 PM 19092616 ER PT J AU Noedl, H Se, Y Schaecher, K Smith, BL Socheat, D Fukuda, MM AF Noedl, Harald Se, Youry Schaecher, Kurt Smith, Bryan L. Socheat, Duong Fukuda, Mark M. CA ARC1 Study Consortium TI Evidence of Artemisinin-Resistant Malaria in Western Cambodia SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Noedl, Harald] Med Univ Vienna, A-1090 Vienna, Austria. [Se, Youry; Schaecher, Kurt; Smith, Bryan L.; Fukuda, Mark M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Socheat, Duong] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. RP Noedl, H (reprint author), Med Univ Vienna, A-1090 Vienna, Austria. EM harald.noedl@meduniwien.ac.at NR 0 TC 692 Z9 710 U1 7 U2 67 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD DEC 11 PY 2008 VL 359 IS 24 BP 2619 EP 2620 DI 10.1056/NEJMc0805011 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 381KG UT WOS:000261534200032 PM 19064625 ER PT J AU Eller, LA Eller, MA Ouma, B Kataaha, P Kyabaggu, D Tumusiime, R Wandege, J Sanya, R Sateren, WB Wabwire-Mangen, F Kibuuka, H Robb, ML Michael, NL de Souza, MS AF Eller, Leigh Anne Eller, Michael A. Ouma, Benson Kataaha, Peter Kyabaggu, Denis Tumusiime, Richard Wandege, Joseph Sanya, Ronald Sateren, Warren B. Wabwire-Mangen, Fred Kibuuka, Hannah Robb, Merlin L. Michael, Nelson L. de Souza, Mark S. TI Reference Intervals in Healthy Adult Ugandan Blood Donors and Their Impact on Conducting International Vaccine Trials SO PLOS ONE LA English DT Article AB Background: Clinical trials are increasingly being conducted internationally. In order to ensure enrollment of healthy participants and proper safety evaluation of vaccine candidates, established reference intervals for clinical tests are required in the target population. Methodology/Principal Findings: We report a reference range study conducted in Ugandan adult blood bank donors establishing reference intervals for hematology and clinical chemistry parameters. Several differences were observed when compared to previously established values from the United States, most notably in neutrophils and eosinophils. Conclusions/Significance: In a recently conducted vaccine trial in Uganda, 31 percent (n = 69) of volunteers screened (n = 223) were excluded due to hematologic abnormalities. If local reference ranges had been employed, 83% of those screened out due to these abnormalities could have been included in the study, drastically reducing workload and cost associated with the screening process. In addition, toxicity tables used in vaccine and drug trial safety evaluations may need adjustment as some clinical reference ranges determined in this study overlap with grade 1 and grade 2 adverse events. C1 [Eller, Michael A.; Sateren, Warren B.; Robb, Merlin L.; de Souza, Mark S.] US Mil HIV Res Program, Rockville, MD USA. [Eller, Leigh Anne; Eller, Michael A.; Ouma, Benson; Kyabaggu, Denis; Tumusiime, Richard; Wandege, Joseph; Sanya, Ronald; Wabwire-Mangen, Fred; Kibuuka, Hannah] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Kataaha, Peter] Uganda Natl Blood Transfus Serv, Kampala, Uganda. [Michael, Nelson L.] Walter Reed Army Inst Res, Rockville, MD USA. [de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok, Thailand. RP Eller, LA (reprint author), US Mil HIV Res Program, Rockville, MD USA. EM leller@muwrp.org FU U.S. Army Medical Research and Materiel Command [W81XWH-04-02-0005]; Henry M. Jackson Foundation for the Advancement of Military Medicine; DAIDS [1Y-A1-26-42-07] FX This work was supported by the U.S. Army Medical Research and Materiel Command and its Cooperative Agreement (W81XWH-04-02-0005) with the Henry M. Jackson Foundation for the Advancement of Military Medicine and with an Inter Agency Agreement (1Y-A1-26-42-07) with DAIDS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 18 TC 25 Z9 26 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 11 PY 2008 VL 3 IS 12 AR e3919 DI 10.1371/journal.pone.0003919 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 436ZU UT WOS:000265455900006 PM 19079547 ER PT J AU Smith, TA AF Smith, Troy Alvin TI Analysis of axisymmetric shell structures under axisymmetric loading by the flexibility method SO JOURNAL OF SOUND AND VIBRATION LA English DT Article ID ROTATIONALLY SYMMETRIC SHELLS; FINITE-DIFFERENCE ANALYSIS; NUMERICAL-ANALYSIS; DYNAMIC-ANALYSIS; REVOLUTION; VIBRATION AB A method is developed for the static stress and deformation analysis of axisymmetric shells under axisymmetric loading by reduction of the shell to ring sections. In particular, the wall thickness of the shell may vary and the method is applicable to the analysis of shells with irregular meridional geometry. Explicit expressions for the influence coefficients for each ring element are derived. In the development of these expressions, exact evaluation of stresses in the circumferential direction of the ring is used. The distribution of stresses in the meridional direction of the ring element is assumed to be linear with each element. By using the derived influence coefficients, the unknown forces at the junctures of the ring elements are found by the standard flexibility method of indeterminate structural analysis. Subsequently, the displacements and internal stresses are determined. Example solutions for a flat circular plate under transverse loading and for a cylindrical shell under a boundary edge loading show excellent agreement with solutions found by solving the governing differential equations. (c) 2008 Elsevier Ltd. All rights reserved. C1 USA, Res Dev & Engn Command, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. RP Smith, TA (reprint author), USA, Res Dev & Engn Command, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA. NR 33 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-460X J9 J SOUND VIB JI J. Sound Vibr. PD DEC 9 PY 2008 VL 318 IS 3 BP 428 EP 460 DI 10.1016/j.jsv.2008.02.056 PG 33 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 356CE UT WOS:000259755500003 ER PT J AU Geisbert, TW Daddario-DiCaprio, KM Geisbert, JB Reed, DS Feldmann, F Grolla, A Stroher, U Fritz, EA Hensley, LE Jones, SM Feldmann, H AF Geisbert, Thomas W. Daddario-DiCaprio, Kathleen M. Geisbert, Joan B. Reed, Douglas S. Feldmann, Friederike Grolla, Allen Stroeher, Ute Fritz, Elizabeth A. Hensley, Lisa E. Jones, Steven M. Feldmann, Heinz TI Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses SO VACCINE LA English DT Article DE Ebola virus; Marburg virus; Filovirus; Nonhuman primates; Aerosol; Vaccines ID ATTENUATED RECOMBINANT VACCINE; HEMORRHAGIC-FEVER; POSTEXPOSURE PROTECTION; EXPERIMENTAL-INFECTION; CYNOMOLGUS MACAQUES; RHESUS-MONKEYS; VECTORS; LIVE; RESPONSES; STRAINS AB Considerable progress has been made over the last decade in developing candidate preventive vaccines that can protect nonhuman primates against Ebola and Marburg viruses. A vaccine based oil recombinant vesicular stomatitis virus (VSV) seems to be particularly robust as it can also confer protection when administered as a postexposure treatment. While filoviruses are not thought to be transmitted by aerosol in nature the inhalation route is among the most likely portals of entry ill the setting of a bioterrorist event. At present, all candidate filoviral vaccines have been evaluated against parenteral challenges but none have been tested against an aerosol exposure. Here, we evaluated our recombinant VSV-based Zaire ebolavirus (ZEBOV) and Marburg Virus (MARV) vaccines against aerosol challenge ill cynomolgus macaques. All monkeys vaccinated with a VSV vector expressing the glycoprotein of ZEBOV were completely protected against an aerosol exposure of ZEBOV. Likewise, all monkeys vaccinated with a VSV vector expressing the glycoprotein of MARV were completely protected against all aerosol exposure of MARV. All control animals challenged by the aerosol route with either ZEBOV or MARV succumbed. Interestingly, disease in control animals appeared to progress slower than previously seen in macaques exposed to comparable doses by intramuscular injection. Published by Elsevier Ltd. C1 [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Geisbert, Thomas W.; Geisbert, Joan B.] Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA. [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA. [Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.; Geisbert, Joan B.; Fritz, Elizabeth A.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. [Reed, Douglas S.] Univ Pittsburgh, Ctr Vaccine Res, Pittsburgh, PA USA. [Feldmann, Friederike; Grolla, Allen; Stroeher, Ute; Jones, Steven M.; Feldmann, Heinz] Publ Hlth Agcy Canada, Special Pathogens Program, Natl Microbiol Lab, Winnipeg, MB, Canada. [Stroeher, Ute; Jones, Steven M.; Feldmann, Heinz] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada. [Jones, Steven M.] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Dept Microbiol, 715 Albany St,R514, Boston, MA 02118 USA. EM geisbert@bu.edu OI Reed, Douglas/0000-0003-0076-9023 FU Defense Threat Reduction Agency [04-4-7J-012]; Public Health Agency of Canada; Canadian Institutes of Health Research [MOP-39321]; Chemical, Biological, Radiological, and Nuclear (CBRN) Research and Technology Initiative (CRTI) FX From USAMRIID, the authors thank John Crarripton and Carlton Rice for animal care and Matthew Lackerneyer and Adam Hedge for assistance with aerosol exposures. From the National Microbiology Laboratory (NML) of the Public Health Agency of Canada (PHAC) the authors thankJason Gren and Anders Leung for technical assistance in biocontainment. We are grateful to John Rose (Yale University) for kindly providing us with the vesicular stornatitis virus reverse genetics system. Work oil filoviruses at LISAMRIID was funded by the Defense Threat Reduction Agency (project number 04-4-7J-012). Work on filoviruses at the National Microbiology Laboratory was Supported by Public Health Agency of Canada, a grant awarded to HF from the Canadian Institutes of Health Research (MOP-39321), and a grant awarded to SMJ from Chemical, Biological, Radiological, and Nuclear (CBRN) Research and Technology Initiative (CRTI). Opinions, interpretations, conclusions, and recornmendations are those of the authors and are not necessarily endorsed by Boston University, the U.S. Army, or the Public Health Agency of Canada. NR 41 TC 93 Z9 99 U1 2 U2 14 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD DEC 9 PY 2008 VL 26 IS 52 BP 6894 EP 6900 DI 10.1016/j.vaccine.2008.09.082 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 386QT UT WOS:000261898400025 PM 18930776 ER PT J AU Chandrahalim, H Bhave, SA Polcawich, R Pulskamp, J Judy, D Kaul, R Dubey, M AF Chandrahalim, Hengky Bhave, Sunil A. Polcawich, Ronald Pulskamp, Jeff Judy, Daniel Kaul, Roger Dubey, Madan TI Performance comparison of Pb(Zr0.52Ti0.48)O-3-only and Pb(Zr0.52Ti0.48)O-3-on-silicon resonators SO APPLIED PHYSICS LETTERS LA English DT Article DE dielectric resonators; lead compounds; micromechanical resonators; oscillators; Q-factor; radiofrequency filters; silicon; zirconium compounds ID PIEZOELECTRIC RESONATORS AB This paper provides a quantitative comparison and explores the design space of lead zirconium titanate (PZT)-only and PZT-on-silicon length-extensional mode resonators for incorporation into radio frequency microelectromechanical system filters and oscillators. We experimentally measured the correlation of motional impedance (R-X) and quality factor (Q) with the resonators' silicon layer thickness (t(Si)). For identical lateral dimensions and PZT-layer thicknesses (t(PZT)), the PZT-on-silicon resonator has higher resonant frequency (f(C)), higher Q (5100 versus 140), lower R-X (51 Omega versus 205 Omega), and better linearity [third-order input intercept point (IIP3) of +43.7 dBm versus +23.3 dBm]. In contrast, the PZT-only resonator demonstrated much wider frequency tuning range (5.1% versus 0.2%). C1 [Chandrahalim, Hengky; Bhave, Sunil A.] Cornell Univ, OxideMEMS Lab, Ithaca, NY 14853 USA. [Polcawich, Ronald; Pulskamp, Jeff; Judy, Daniel; Kaul, Roger; Dubey, Madan] USA, Res Lab, Adelphi, MD 20783 USA. RP Chandrahalim, H (reprint author), Cornell Univ, OxideMEMS Lab, Ithaca, NY 14853 USA. EM hc287@cornell.edu RI Chandrahalim, Hengky/F-1475-2016 OI Chandrahalim, Hengky/0000-0003-1930-1359 NR 13 TC 30 Z9 30 U1 0 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 8 PY 2008 VL 93 IS 23 AR 233504 DI 10.1063/1.3046717 PG 3 WC Physics, Applied SC Physics GA 383UP UT WOS:000261699700080 ER PT J AU Chen, MK Kim, JH Yang, CE Yin, SS Hui, RQ Ruffin, P AF Chen, Meng-Ku Kim, Jae Hun Yang, Chia-En Yin, Stuart Shizhuo Hui, Rongqing Ruffin, Paul TI Terahertz generation in multiple laser-induced air plasmas SO APPLIED PHYSICS LETTERS LA English DT Article DE plasma production by laser; plasma waves; submillimetre wave generation ID COHERENT CONTROL AB An investigation of the terahertz wave generation in multiple laser-induced air plasmas is presented. First, it is demonstrated that the intensity of the terahertz wave increases as the number of air plasmas increases. Second, the physical mechanism of this enhancement effect of the terahertz generation is studied by quantitatively measuring the intensity of the generated terahertz wave as a function of phase difference between adjacent air plasmas. It is found out that the superposition is the main mechanism to cause this enhancement. Thus, the results obtained in this paper not only provide a technique to generate stronger terahertz wave but also enable a better understanding of the mechanism of the terahertz generation in air plasma. C1 [Chen, Meng-Ku; Kim, Jae Hun; Yang, Chia-En; Yin, Stuart Shizhuo] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Hui, Rongqing] Univ Kansas, Dept Elect Engn & Comp Sci, Lawrence, KS 66045 USA. [Ruffin, Paul] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Yin, SS (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM muc202@psu.edu; sxy105@psu.edu OI Kim, Jae-Hun/0000-0001-6537-0350 FU Office of Naval Research [N00014-08-1-0538] FX Partial financial support of this work by Office of Naval Research (Grant No. N00014-08-1-0538) is greatly appreciated. The authors also gratefully acknowledge helpful discussions and technical support from Zhiwen Liu and Peng Li. NR 9 TC 15 Z9 15 U1 3 U2 9 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 8 PY 2008 VL 93 IS 23 AR 231102 DI 10.1063/1.3046122 PG 3 WC Physics, Applied SC Physics GA 383UP UT WOS:000261699700002 ER PT J AU Engler, RJM Nelson, MR Klote, MM VanRaden, MJ Huang, CY Cox, NJ Klimov, A Keitel, WA Nichol, KL Carr, WW Treanor, JJ AF Engler, Renata J. M. Nelson, Michael R. Klote, Mary M. VanRaden, Mark J. Huang, Chiung-Yu Cox, Nancy J. Klimov, Alexander Keitel, Wendy A. Nichol, Kristin L. Carr, Warner W. Treanor, John J. CA Walter Reed Hlth Care Syst Influen TI Half- vs Full-Dose Trivalent Inactivated Influenza Vaccine (2004-2005) Age, Dose, and Sex Effects on Immune Responses SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID HEALTH-CARE WORKERS; RANDOMIZED CONTROLLED-TRIAL; LONG-TERM-CARE; ANTIBODY-RESPONSES; COST-EFFECTIVENESS; ELDERLY PERSONS; WORKING ADULTS; VIRUS; SERUM; MORTALITY AB Background: Optimal public health strategies for managing influenza vaccine shortages are not yet defined. Our objective was to determine the effects of age, sex, and dose on the immunogenicity of intramuscular trivalent inactivated vaccine (TIV). Methods: Healthy adults aged 18 to 64 years, stratified by age (18-49 and 50-64 years) and sex, were randomized to receive full- or half-dose TIV. Hemagglutination inhibition titers against vaccine antigens were measured before and 21 days after immunization. A primary outcome of noninferiority was defined as a difference of less than 20% in the upper 95% confidence interval (CI) of the proportion of subjects with strain-specific hemagglutination inhibition antibody titers of 1:40 or higher after vaccination. Secondary outcomes included geometric mean titers, after vaccination side effects, and occurrences of influenza-like illnesses. Results: Among previously immunized subjects (N=1114) receiving half- vs full-dose TIV (age, 18-49 years, n=284 [half] and n=274 [full]; and age 50-64 years, n=276 [half] and n=280 [full]), CIs for proportions of subjects with hemagglutination inhibition antibody titers of 1:40 or higher excluded substantial reduction for all antigens in the 18- to 49-year age group and for B/Shanghai/361/2002 (B) and A/Fujian/411/2002 (A/H3N2) in the 50- to 64-year age group. Geometric mean titer in the female 18- to 49-year age group exceeded male responses for all strains: responses to half- dose TIV that were comparable with male full- dose responses for A/ New Caledonia/20/99 (A/H1N1) antigen, 25.4 (95% CI, 20.9-30.9) vs 25.6 (95% CI, 21.3-30.9); A/H3N2 antigen, 60.8 (95% CI, 50.8-72.7) vs 44.1 (95% CI, 37.6-51.8); and B antigen, 64.4 (95% CI, 53.9-76.9) vs 60.7 (95% CI, 51.4-71.7) (findings were similar for the 50- to 64- year age group). Some injection site and systemic reactions (myalgias and/or arthralgias [P<.05], headache [P<.001], and impact of fatigue [P<.05]) were significantly lower in men. The relative risk of medical visits and hospitalizations for influenza-like illnesses were similar in the half- and full- dose groups regardless of age. Conclusions: Antibody responses to intramuscular half-dose TIV in healthy, previously immunized adults were not substantially inferior to the full- dose vaccine, particularly for ages 18 to 49 years. Significantly higher geometric mean titer responses in women were identified for all ages, regardless of dose or influenza strain. Half-dose vaccination may be an effective strategy for healthy adults younger than 50 years in the setting of an influenza vaccine shortage. Trial Registration: clinicaltrials.gov Identifier: NCT00283283 C1 [Engler, Renata J. M.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Allergy Immunol Dept, Washington, DC 20307 USA. [VanRaden, Mark J.; Huang, Chiung-Yu] NIAID, NIH, Bethesda, MD 20892 USA. [Cox, Nancy J.; Klimov, Alexander] Ctr Dis Control & Prevent, Influenza Branch, Atlanta, GA USA. [Keitel, Wendy A.] Baylor Coll Med, Houston, TX 77030 USA. [Nichol, Kristin L.] Univ Minnesota, Sch Med, VA Med Ctr, Minneapolis, MN 55455 USA. [Nichol, Kristin L.] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA. [Treanor, John J.] Univ Rochester, Dept Med, Infect Dis Unit, Rochester, NY USA. RP Engler, RJM (reprint author), Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Allergy Immunol Dept, 6900 Georgia Ave NW,Bldg 41,Ste 21, Washington, DC 20307 USA. EM renata.engler@gmail.com FU Office of the Army Surgeon General in collaboration with Walter Reed Army Medical Center(WRAMC); Healthcare System; North Atlantic Regional Medical Command; US Army Medical Research and Materiel Command; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Influenza Branch of the Centers for Disease Control and Prevention FX This study was supported by the Office of the Army Surgeon General in collaboration with Walter Reed Army Medical Center(WRAMC) and Healthcare System; the North Atlantic Regional Medical Command; the US Army Medical Research and Materiel Command; the National Institute of Allergy and Infectious Diseases, National Institutes of Health; and the Influenza Branch of the Centers for Disease Control and Prevention. NR 34 TC 68 Z9 68 U1 0 U2 6 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD DEC 8 PY 2008 VL 168 IS 22 BP 2405 EP 2414 DI 10.1001/archinternmed.2008.513 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 380SX UT WOS:000261486600004 PM 19064822 ER PT J AU Drew, C Bosselman, S Ziegler, D AF Drew, Christopher Bosselman, Suzanne Ziegler, David TI Mixed Morphology by the Extrusion of Phase-Separated Blends of a Melt-Processed Polymer and Polymer Solution SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article DE block copolymers; compatibilization; composites; phase separation; self-organization ID BLOCK-COPOLYMER; MICROEMULSION; PRESSURE; FILMS; RATIO AB The phase behavior and structure development in immiscible blends of melt-extruded polycaprolactone and a viscous aqueous poly(ethylene oxide) solution were investigated. The coextrusion of an aqueous polymer solution and a molten polymer is a largely unexplored technique and offers exciting potential for creating new materials via the execution of chemical reactions in the aqueous phase. Samples were prepared both with and without a block copolymer acting as a surface-active agent. The resulting morphology was characterized with scanning electron microscopy after the removal of the watersoluble phase. Spheres, rods, fibers, and cocontinuous gyroidal structures were observed, yet the exact phase inversion was not observed, and the changes in the feature shape depended on which component composed the major phase. Significant orientation in the flow direction was observed when the less viscous poly(ethylene oxide) was the major phase, whereas orientation was minimal when polycaprolactone was the major phase. These observations indicate that control of the feature shape and orientation may be accomplished through the control of the viscosity. The spontaneous formation of an outer layer of polycaprolactone in all samples was observed, suggesting that the morphology could be induced by control of the material interaction with the extruder die wall. The inclusion of a diblock copolymer significantly reduced the feature size but did not alter the morphology type. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 110: 2841-2848, 2008 C1 [Drew, Christopher; Bosselman, Suzanne; Ziegler, David] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Drew, C (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, Kansas St, Natick, MA 01760 USA. EM christopher.p.drew@us.army.mil FU Natick Soldier Research; Development and Engineering Center-In-House Laboratory Independent Research FX Contract grant sponsor: Natick Soldier Research, Development and Engineering Center-In-House Laboratory Independent Research. NR 26 TC 0 Z9 0 U1 2 U2 5 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD DEC 5 PY 2008 VL 110 IS 5 BP 2841 EP 2848 DI 10.1002/app.28799 PG 8 WC Polymer Science SC Polymer Science GA 361BP UT WOS:000260102800041 ER PT J AU Ramsey, JJ Pan, E Chung, PW AF Ramsey, J. J. Pan, E. Chung, P. W. TI Modelling of strain fields in quantum wires with continuum methods and molecular statics SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID ELASTIC PROPERTIES; SIMULATION; DYNAMICS; SEMICONDUCTORS; PROFILES; GROWTH; SCALE; INAS; DOTS AB The maximum and minimum principal strains of an InAs quantum wire (QWR) buried in a GaAs matrix are computed using the boundary element method (BEM), the inclusion method, and molecular statics, and the results from each method are compared with each other. The first two methods are based on continuum mechanics and linear elasticity, while the third is atomistic. The maximum principal strains are largely in agreement among the different methods, especially outside the QWR, though in the centre of the QWR, the discrepancy between the continuum and atomistic methods can be as large as 11.9%. The gradients of the strain tensor are in agreement among the methods. The inclusion method is faster than the BEM, and both continuum methods are an order of magnitude faster than molecular statics. Although the inclusion method, unlike the BEM, ignores the difference in material properties between the QWR and its surrounding matrix, its results are in better agreement with the molecular statics results than the results from the BEM. The rough quantitative and qualitative agreements indicate the utility of classical continuum methods for estimating strain profiles in nanoscale structures. C1 [Ramsey, J. J.; Pan, E.] Univ Akron, Dept Civil Engn, Akron, OH 44325 USA. [Ramsey, J. J.; Pan, E.] Univ Akron, Dept Appl Math, Akron, OH 44325 USA. [Chung, P. W.] USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Ramsey, JJ (reprint author), Univ Akron, Dept Civil Engn, 302 E Buchtel Mall, Akron, OH 44325 USA. EM jjr19@uakron.edu; pan2@uakron.edu; pchung@arl.army.mil RI Pan, Ernian/F-4504-2011 OI Pan, Ernian/0000-0001-6640-7805 FU Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) [W911NF-06-2-0038] FX This work was supported by the Defense Threat Reduction Agency Joint Science and Technology Office (DTRA-JSTO) under the grant W911NF-06-2-0038. Also, while the final molecular statics calculations were done on our own PCs, preliminary molecular statics calculations were supported in part by an allocation of computing time from the Ohio Supercomputing Center. NR 34 TC 3 Z9 3 U1 0 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD DEC 3 PY 2008 VL 20 IS 48 AR 485215 DI 10.1088/0953-8984/20/48/485215 PG 12 WC Physics, Condensed Matter SC Physics GA 370JP UT WOS:000260758800025 ER PT J AU Miklossy, J Steele, JC Yu, S McCall, S Sandberg, G McGeer, EG McGeer, PL AF Miklossy, Judith Steele, John C. Yu, Sheng McCall, Sherman Sandberg, Glenn McGeer, Edith G. McGeer, Patrick L. TI Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC) SO ACTA NEUROPATHOLOGICA LA English DT Article DE Alzheimer's disease; alpha-Synuclein; beta-Amyloid protein; Coiled body; Neurofibrillary tangles; Parkinsonism; Tau; TDP-43 ID PROGRESSIVE SUPRANUCLEAR PALSY; PARKINSONISM-DEMENTIA; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; NEURODEGENERATIVE DISORDERS; A-BETA; CLINICAL-FEATURES; ENDEMIC DISEASE; SCLEROSIS; PROTEIN AB Guam ALS/PDC is a severe tangle forming disorder endemic to Guam with features overlapping such neurodegenerative disorders as Alzheimer disease (AD), Parkinson disease (PD), progressive supranuclear palsy (PSP), ALS, corticobasal degeneration (CBD) and pallido-ponto-nigral degeneration (PPND). Since the prevalence is declining, we examined brain tissue from 35 clinically diagnosed Chamorro patients with ALS/PDC and two Chamorro controls autopsied between 1946 and 2006, to determine if distinct variations in the pathology could be identified up to this time. Although the age at autopsy increased by 4.5-5 years per decade, we identified no qualitative differences in pathological deposits with antibodies against tau, ubiquitin, A beta, alpha-synuclein and TDP-43, indicating that these more recently identified proteins have been involved in the neuropathogenesis over the past 6 decades. Tau and TDP-43 positive neuronal, oligodendroglial and astrocytic inclusions involving multiple nerve fiber tracts occurred in both the ALS and PDC types, reinforcing the concept that these forms are part of the same disorder. The results obtained may help to define the commonality of the Guam disease with other tangle forming disorders and may help in monitoring the epidemiological changes that are taking place. C1 [Miklossy, Judith; Yu, Sheng; McGeer, Edith G.; McGeer, Patrick L.] Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V6T IZ3, Canada. [Steele, John C.] Guam Mem Hosp, Tamuning, GU USA. [McCall, Sherman] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Sandberg, Glenn] Armed Forces Inst Pathol, Washington, DC 20306 USA. RP McGeer, PL (reprint author), Univ British Columbia, Kinsmen Lab Neurol Res, 2255 Wesbrook Mall, Vancouver, BC V6T IZ3, Canada. EM mcgeerpl@interchange.ubc.ca FU Pacific Alzheimer Research Foundation FX This paper was supported by a Grant from the Pacific Alzheimer Research Foundation. We thank H. Akiyama, L. Binder, B. Giasson, H. Mori and K. Obi for their generous gifts of key antibodies and H. Martin and J. P. Guo for technical assistance in preparing figures. NR 45 TC 39 Z9 39 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0001-6322 J9 ACTA NEUROPATHOL JI Acta Neuropathol. PD DEC PY 2008 VL 116 IS 6 BP 625 EP 637 DI 10.1007/s00401-008-0439-2 PG 13 WC Clinical Neurology; Neurosciences; Pathology SC Neurosciences & Neurology; Pathology GA 374EH UT WOS:000261025200005 PM 18843496 ER PT J AU Seyedabbasi, MA Farthing, MW Imhoff, PT Miller, CT AF Seyedabbasi, Mir Ahmad Farthing, Matthew W. Imhoff, Paul T. Miller, Cass T. TI The influence of wettability on NAPL dissolution fingering SO ADVANCES IN WATER RESOURCES LA English DT Article DE Nonaqueous phase liquids; Mass transfer; Preferential flow; Upscaling ID NONAQUEOUS PHASE LIQUID; SATURATED POROUS-MEDIA; MASS-TRANSFER RATES; FRACTIONAL WETTABILITY; HYDRAULIC CONDUCTIVITY; RESIDUAL TETRACHLOROETHYLENE; RELATIVE PERMEABILITIES; SUBSURFACE SYSTEMS; MODEL; 2-FLUID AB Laboratory experiments and numerical simulations in homogeneous porous media were used to investigate the influence of porous medium wettability on the formation and growth of preferential dissolution pathways, dissolution fingers, during nonaqueous phase liquid (NAPL) dissolution. As the porous medium became increasingly NAPL-wet, dissolution fingers grew wider and slower. This result was observed in physical experiments with 0% and 100% NAPL-wet conditions and confirmed with numerical simulations at these and intermediate wettabilities. A previously derived expression for an upscaled mass transfer rate coefficient that accounts for the growth of dissolution fingers was used to quantify the effect of fingering on overall NAPL removal rates. For the test cases evaluated, NAPL dissolution fingering controlled the overall rate of NAPL dissolution after the dissolution front moved 4 cm, in 0% NAPL-wet conditions and 18 cm in 100% NAPL-wet conditions. Thus, even in completely NAPL-wet media dissolution fingering may control the overall rate of NAPL dissolution after relatively short travel distances. The importance of NAPL dissolution fingering in heterogeneous systems with spatially varying NAPL saturations, though, remains an important question for future work. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Seyedabbasi, Mir Ahmad; Imhoff, Paul T.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Farthing, Matthew W.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Miller, Cass T.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27515 USA. RP Imhoff, PT (reprint author), Univ Delaware, Dept Civil & Environm Engn, 301 DuPont Hall, Newark, DE 19716 USA. EM ahmad@udel.edu; matthew.w.farthing@erdc.usace.army.mil; imhoff@udel.edu; casey_mil-ler@unc.edu RI Miller, Cass T./I-6613-2012 OI Miller, Cass T./0000-0001-6082-9273 FU National Science Foundation [0440236] FX Nathan Kiracofe provided considerable assistance in relative permeability measurements at the University of Delaware. For the numerical simulations permission was granted by the Chief of Engineers to publish this information. This work was supported by National Science Foundation Grant 0440236. NR 44 TC 14 Z9 14 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1708 J9 ADV WATER RESOUR JI Adv. Water Resour. PD DEC PY 2008 VL 31 IS 12 BP 1687 EP 1696 DI 10.1016/j.advwatres.2008.08.003 PG 10 WC Water Resources SC Water Resources GA 388NP UT WOS:000262026800013 ER PT J AU Orio, PF Merick, GS Grimm, P Blasko, J Sylvester, J Allen, ZA Butler, WM Chaudhry, UUH AF Orio, Peter F., III Merick, Gregory S. Grimm, Peter Blasko, John Sylvester, John Allen, Zachariah A. Butler, Wayne M. Chaudhry, Usman-ul-Haq TI Effects of the Time Interval Between Prostate Brachytherapy and Postimplant Dosimetric Evaluation in Community Practice Analysis of the Pro-Qura Database SO AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS LA English DT Article DE prostate; brachytherapy; quality; dosimetry ID EDEMA; I-125; IMPLANTS; IMPACT; PD-103; CANCER; DEPENDENCE; CARCINOMA; OUTCOMES; QUALITY AB Objective: To evaluate the influence of postimplant dosimetric timing on prostate brachytherapy quality in community practice. Materials and Methods: The Pro-Qura database was stratified by multiple time intervals between the implant and postimplant dosimetric analysis. Postimplant dosimetry was performed in a standardized fashion. Criteria for implant adequacy included V-100 >80%, D-90 >90%, and V-150 <60% for I-125 and <75% for Pd-103. Implants with V-100 <80% and D-90 <90% were deemed "too cool." Implants were considered "too hot" if D-90 >140% of prescription dose and/or V-150 >150% for I-125 and >75% for Pd-103. Results: For I-125, the average V-100 and D-90 increased from 88.6% to 89.8%, and 102.8% to 103.1 % for day 0 and day 30 dosimetry. For Pd-103 implants the change was more pronounced, with V-100 and D-90 increasing front 81.6% to 87.8% (P < 0.001) and 88.7% to 100.0% (P < 0.001) for day 0, and day 30, respectively. The percentage of implants considered too cool based on a V-100 and D-90 criteria decreased from 18.8% and 26.9% on day 0 to 11.0% and 19.7% on day 30, respectively. Implants determined to be too hot based on a V-150 >60% (I-125)/>75% (Pd-103) or D-90 >140% were 16.4% and 2.2% on day 0 and 16.0% and 0.7% on day 30, respectively. Conclusion: In community-based brachytherapy programs, postimplant dosimetry performed at day 30 resulted in a statistically and clinically significant improvement in postimplant dosimetry cornpared with day 0. The influence of timing is Substantially greater for Pd-103 than I-125. C1 [Merick, Gregory S.] Wheeling Hosp, Schiffler Canc Ctr, Wheeling, WV 26003 USA. [Merick, Gregory S.; Allen, Zachariah A.; Butler, Wayne M.; Chaudhry, Usman-ul-Haq] Wheeling Jesuit Univ, Wheeling, WV USA. [Orio, Peter F., III] Brooke Army Med Ctr, Dept Radiat Oncol, Ft Sam Houston, TX 78234 USA. [Grimm, Peter; Blasko, John; Sylvester, John] Swedish Med Ctr, Seattle Prostate Inst, Seattle, WA USA. RP Merick, GS (reprint author), Wheeling Hosp, Schiffler Canc Ctr, 1 Med Pk, Wheeling, WV 26003 USA. EM gmerrick@urologicresearchinstitute.org NR 28 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0277-3732 EI 1537-453X J9 AM J CLIN ONCOL-CANC JI Am. J. Clin. Oncol.-Cancer Clin. Trials PD DEC PY 2008 VL 31 IS 6 BP 523 EP 531 DI 10.1097/COC.0b013e31816fc95a PG 9 WC Oncology SC Oncology GA 382CN UT WOS:000261582700001 PM 19060582 ER PT J AU Nevin, RL Carbonell, I Thurmond, V AF Nevin, Remington L. Carbonell, Ivan Thurmond, Veronica TI Device-specific rates of needlestick injury at a large military teaching hospital SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article ID HEALTH-CARE WORKERS AB The device-specific needlestick injury (NSI) rate provides a means of comparing rates of injury between work sites and institutions over time. We performed a retrospective study of intravenous and percutaneous injection NSI at a large military teaching hospital using electronic purchase records and occupational NSI exposure forms to define action levels for process improvements. A rate of 2.25 NSI per 100,000 intravenous needles and 2.21 NSI per 100,000 percutaneous needles was found. (Am J infect Control 2008;36:750-2.) C1 [Nevin, Remington L.] USA, Silver Spring, MD 20910 USA. [Carbonell, Ivan] Walter Reed Army Med Ctr, Occupat Hlth Clin, Washington, DC 20307 USA. [Thurmond, Veronica] Womack Army Med Ctr, Dept Res, Ft Bragg, NC USA. RP Nevin, RL (reprint author), USA, 2900 Linden Lane,Suite 200, Silver Spring, MD 20910 USA. EM remington.nevin@us.army.mil OI Nevin, Remington/0000-0002-0534-1889 NR 10 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD DEC PY 2008 VL 36 IS 10 BP 750 EP 752 DI 10.1016/j.ajic.2008.02.006 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 385FY UT WOS:000261801300012 PM 18834746 ER PT J AU Mcllwain, DS Gates, K Ciliax, D AF Mcllwain, D. Scott Gates, Kathy Ciliax, Donald TI Heritage of Army Audiology and the Road Ahead: The Army Hearing Program SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article AB Noise-induced hearing loss has been documented as early as the 16th century, when a French surgeon, Ambroise Pare, wrote of the treatment of injuries sustained by firearms and described acoustic trauma in great detail. Even so, the protection of hearing would not be addressed for three more centuries, when the jet engine was invented and resulted in a long overdue whirlwind of policy development addressing the prevention of hearing loss. We present a synopsis of hearing loss prevention in the US Army and describe the current Army Hearing Program, which aims to prevent noise-induced hearing loss in soldiers and to ensure their maximum combat effectiveness. (Am J Public Health. 2008;98:2167-2172. doi:10.2105/AJPH.2007.128504) C1 [Mcllwain, D. Scott] USA, Dept Med, Ctr & Sch, Dept Prevent Hlth Serv, Ft Sam Houston, TX USA. [Gates, Kathy] USA, Proponency Off Prevent Med, Falls Church, VA USA. [Ciliax, Donald] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. RP Mcllwain, DS (reprint author), Hearwell LLC, 6100 Neil Rd,Suite 500, Reno, NV 89511 USA. EM scott@hearwell.org NR 20 TC 5 Z9 5 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 EI 1541-0048 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2008 VL 98 IS 12 BP 2167 EP 2172 DI 10.2105/AJPH.2007.128504 PG 6 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 378GP UT WOS:000261309500015 ER PT J AU Riddle, MS Tribble, DR Putnam, SD Mostafa, M Brown, TR Letizia, A Armstrong, AW Sanders, JW AF Riddle, Mark S. Tribble, David R. Putnam, Shannon D. Mostafa, Manal Brown, Theodore R. Letizia, Andrew Armstrong, Adam W. Sanders, John W. TI Past Trends and Current Status of Self-Reported Incidence and Impact of Disease and Nonbattle Injury in Military Operations in Southwest Asia and the Middle East SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID ENDURING FREEDOM; IRAQI FREEDOM; DESERT-SHIELD; US MILITARY; TRAVELERS DIARRHEA; EPIDEMIOLOGY; POPULATIONS; AFGHANISTAN; PERSONNEL; ETIOLOGY AB Objectives. To evaluate the evolutional changes in disease and nonbattle injury in a long-term deployment setting, we investigated trends of selected disease and nonbattle injury (NBI) incidence among US military personnel deployed in ongoing military operations in Southwest Asia and the Middle East. Methods. Participants completed an anonymous questionnaire concerning diarrhea, acute respiratory illness (ARI), and NBIs. We compared incidence, morbidity, and risk associations of disease and NBI incidence with historical data. We analyzed a clinic screening form to describe trends in diarrhea incidence over a 3-year period. Results. Between April 2006 and March 2007, 3374 troops completed deployment questionnaires. Incidence of diarrhea was higher than that of ARI and NBI (12.1, 7.1, and 2.5 episodes per 100 person-months, respectively), but ARI and NBI resulted in more-frequent health system utilization (both P<.001) and decreased work performance (P<.001 and P=.05, respectively) than did diarrhea. Compared with historical disease and NBI incidence rates, diarrhea and NBI incidence declined over a 4-year period, whereas ARI remained relatively constant. Conclusions. Diarrhea, ARI, and NBI are important health concerns among deployed military personnel. Public health and preventive measures are needed to mitigate this burden. (Am J Public Health. 2008;98:2199-2206. doi:10.2105/AJPH.2007.131680) C1 [Riddle, Mark S.] USN, Enter Dis Dept, Med Res Ctr, Silver Spring, MD 20910 USA. [Tribble, David R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Putnam, Shannon D.] USN, Med Res Unit 2, Jakarta, Indonesia. [Mostafa, Manal; Armstrong, Adam W.] USN, Med Res Unit 3, Cairo, Egypt. [Brown, Theodore R.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Letizia, Andrew] Branch Med Clin, Capodichino, Italy. [Sanders, John W.] USN, Med Res Ctr Detachment, Lima, Peru. RP Riddle, MS (reprint author), USN, Enter Dis Dept, Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM markriddemd@hotmail.com RI Riddle, Mark/A-8029-2011 FU Military Infectious Disease Research Program and Department of Defense [6000.Rad1.D.E0301] FX This study was funded by the Military Infectious Disease Research Program and Department of Defense under work unit no. 6000.Rad1.D.E0301. NR 26 TC 22 Z9 22 U1 0 U2 1 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD DEC PY 2008 VL 98 IS 12 BP 2199 EP 2206 DI 10.2105/AJPH.2007.131680 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 378GP UT WOS:000261309500022 PM 18923114 ER PT J AU Boyle, K Whittington, J Deriso, E Alefantis, T Bergmann-Leitner, ES Grewal, P DelVecchio, V Angov, E AF Boyle, Katharine Whittington, Jessica Deriso, Elizabeth Alefantis, Timothy Bergmann-Leitner, Elke S. Grewal, Paul DelVecchio, Vito Angov, Evelina TI IMMUNITY INDUCED BY PLASMODIUM BERGHEI CSP EXPRESSION FROM VARIOUS CELLULAR LOCALIZATIONS AND DELIVERY BY INACTIVATED ESCHERICHIA COLI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Boyle, Katharine; Deriso, Elizabeth; Bergmann-Leitner, Elke S.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Whittington, Jessica; Alefantis, Timothy; Grewal, Paul; DelVecchio, Vito] Vital Probes Inc, Mayfield, PA USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 2 BP 1 EP 1 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600003 ER PT J AU Patterson, NB Bruder, JT Limbach, K Moretz, SE Zhou, H Diouf, A King, CR Gowda, K Chen, P Konovalova, S Bergmann-Leitner, ES Locke, E Soisson, L Diggs, C Angov, E Long, CA Richie, TL Doolan, DL AF Patterson, Noelle B. Bruder, Joseph T. Limbach, Keith Moretz, Samuel E. Zhou, Hong Diouf, Ababacar King, C. Richter Gowda, Kalpana Chen, Ping Konovalova, Svetlana Bergmann-Leitner, Elke S. Locke, Emily Soisson, Lorraine Diggs, Carter Angov, Evelina Long, Carole A. Richie, Thomas L. Doolan, Denise L. TI THE FIRST GENERATION PLASMODIUM FALCIPARUM AMA-1 BASED MONOVALENT ADENOVECTOR VACCINE AND THE SECOND GENERATION BIVALENT ADENOVECTOR VACCINE EXPRESSING PLASMODIUM FALCIPARUM AMA-1 AND MSP1-42 ELICIT ROBUST FUNCTIONAL ANTIBODIES IN NZW RABBIT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Patterson, Noelle B.; Limbach, Keith; Gowda, Kalpana; Bergmann-Leitner, Elke S.; Angov, Evelina; Richie, Thomas L.; Doolan, Denise L.] Naval Med Res Ctr, US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Patterson, Noelle B.; Limbach, Keith; Gowda, Kalpana; Bergmann-Leitner, Elke S.; Angov, Evelina; Richie, Thomas L.; Doolan, Denise L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Bruder, Joseph T.; King, C. Richter; Chen, Ping; Konovalova, Svetlana] GenVec Inc, Gaithersburg, MD USA. [Moretz, Samuel E.; Zhou, Hong; Diouf, Ababacar; Long, Carole A.] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD USA. [Locke, Emily] PATH Malaria Vaccine Initiat, Bethesda, MD USA. [Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. RI Bergmann-Leitner, Elke/B-3548-2011; Doolan, Denise/F-1969-2015 OI Bergmann-Leitner, Elke/0000-0002-8571-8956; NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 5 BP 2 EP 2 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600006 ER PT J AU Tamminga, C Chuang, I Regis, D Mendoza-Silveiras, J Epstein, JE Parekh, F Reyes, S Steinbeiss, V Fedders, C Maiolatesi, S Smith, K Williams, F Sedegah, M Doolan, DL Limbach, K Patterson, NB Spring, M Bruder, JT King, CR Soisson, L Diggs, C Ockenhouse, CF Richie, T AF Tamminga, Cindy Chuang, Ilin Regis, David Mendoza-Silveiras, Jose Epstein, Judith E. Parekh, Falgunee Reyes, Sharina Steinbeiss, Victoria Fedders, Charlotte Maiolatesi, Santina Smith, Kathryn Williams, Francis Sedegah, Martha Doolan, Denise L. Limbach, Keith Patterson, Noelle B. Spring, Michele Bruder, Joseph T. King, C. R. Soisson, Lorraine Diggs, Carter Ockenhouse, Christian F. Richie, Thomas TI SAFETY AND TOLERABILITY OF A MULTI-STAGE, MULTI-ANTIGEN ADENOVIRUS-VECTORED PLASMODIUM FALCIPARUM MALARIA VACCINE, IN HEALTHY, MALARIA-NAIVE ADULTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Tamminga, Cindy; Chuang, Ilin; Regis, David; Mendoza-Silveiras, Jose; Epstein, Judith E.; Parekh, Falgunee; Reyes, Sharina; Steinbeiss, Victoria; Fedders, Charlotte; Maiolatesi, Santina; Smith, Kathryn; Sedegah, Martha; Doolan, Denise L.; Limbach, Keith; Patterson, Noelle B.; Spring, Michele; Ockenhouse, Christian F.; Richie, Thomas] Naval Med Res Ctr, Walter Reed Army Inst Res, Silver Spring, MD USA. [Williams, Francis] Natl Naval Med Ctr, Bethesda, MD USA. [Bruder, Joseph T.; King, C. R.] GenVec Inc, Gaithersburg, MD USA. [Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Washington, DC 20523 USA. RI Doolan, Denise/F-1969-2015 NR 0 TC 0 Z9 0 U1 2 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 7 BP 3 EP 3 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600008 ER PT J AU Thera, MA Doumbo, OK Coulibaly, D Laurens, MB Kone, AK Guindo, AB Diallo, DA Traore, K Diarra, I Niangaly, A Dolo, A Daou, M Sissoko, M Sissoko, MS Kouriba, B Traore, D Lyke, KE Takala, SL Godeaux, O Diggs, C Dutta, S Stewart, VA House, B Heppner, DG Plowe, CV Cohen, J Ballou, WR Thonnard, J Dubois, MC Soisson, L Ware, LA Lanar, DE AF Thera, Mahamadou A. Doumbo, Ogobara K. Coulibaly, Drissa Laurens, Matthew B. Kone, Abdoulaye K. Guindo, Ando B. Diallo, Dapa A. Traore, Karim Diarra, Issa Niangaly, Amadou Dolo, Amagana Daou, Modibo Sissoko, Mady Sissoko, Mahamadou S. Kouriba, Bourema Traore, Drissa Lyke, Kirsten E. Takala, Shannon L. Godeaux, Olivier Diggs, Carter Dutta, Sheetij Stewart, V. Ann House, Brent Heppner, D. Gray Plowe, Christopher V. Cohen, Joe Ballou, W. Ripley Thonnard, Joelle Dubois, Marie-Claude Soisson, Lorraine Ware, Lisa A. Lanar, David E. TI RANDOMIZED, CONTROLLED, PHASE 2B CLINICAL TRIAL TO EVALUATE THE SAFETY, IMMUNOGENICITY AND EFFICACY OF WALTER REED ARMY INSTITUTE OF RESEARCH'S AMA-1 MALARIA VACCINE (FMP2.1) ADJUVANTED IN GSK BIOLOGICALS' AS02 VS. RABIES VACCINE IN 1-6 YEAR OLD CHILDREN IN BANDIAGARA, MALI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Thera, Mahamadou A.; Doumbo, Ogobara K.; Coulibaly, Drissa; Kone, Abdoulaye K.; Guindo, Ando B.; Diallo, Dapa A.; Traore, Karim; Diarra, Issa; Niangaly, Amadou; Dolo, Amagana; Daou, Modibo; Sissoko, Mady; Sissoko, Mahamadou S.; Kouriba, Bourema; Traore, Drissa] Univ Bamako, Fac Med, Bamako, Mali. [Laurens, Matthew B.; Lyke, Kirsten E.; Takala, Shannon L.; Plowe, Christopher V.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Godeaux, Olivier; Cohen, Joe; Ballou, W. Ripley; Dubois, Marie-Claude] GlaxoSmithKline Biol, Rixensart, Belgium. [Diggs, Carter] US Agcy Int Dev, Washington, DC 20523 USA. [Dutta, Sheetij; Stewart, V. Ann; House, Brent; Heppner, D. Gray; Ware, Lisa A.; Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Lanar, David/B-3560-2011 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 25 BP 8 EP 8 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600026 ER PT J AU Parker, M Fine, D Glass, P Terpening, S Mallory, R Helbers, S AF Parker, Michael Fine, Donald Glass, Pamela Terpening, Sara Mallory, Rayburn Helbers, Sarah TI PHASE I CLINICAL TRIAL OF V3526, VIROLOGICAL AND SEROLOGICAL ANALYSES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Parker, Michael; Glass, Pamela; Mallory, Rayburn] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Fine, Donald; Terpening, Sara] Dymport Vaccine Co LLC, Frederick, MD USA. [Helbers, Sarah] Commonwealth Biotechnol Inc, Richmond, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 62 BP 19 EP 19 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600063 ER PT J AU Campagna, JD Nemmers, ST AF Campagna, John D. Nemmers, Suzie T. TI OPHTHALMOMYIASIS BY CALLIPHORIDAE LARVAE IN A 16-YEAR-OLD FEMALE FROM HAWAII SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Campagna, John D.; Nemmers, Suzie T.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 69 BP 21 EP 21 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600070 ER PT J AU Hartzell, JD Gleeson, T Ockenhouse, C Wortmann, G AF Hartzell, Joshua D. Gleeson, Todd Ockenhouse, Chris Wortmann, Glenn TI Q FEVER COMPLICATED BY OGILVIE'S SYNDROME IN A US SOLDIER SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Hartzell, Joshua D.; Wortmann, Glenn] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Gleeson, Todd] Natl Naval Med Ctr, Bethesda, MD USA. [Ockenhouse, Chris] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 95 BP 28 EP 28 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600096 ER PT J AU Thomas, S Nisalak, A Libraty, D Sahasakmontri, N Kalayanarooj, S Vaughn, D Putnak, R Endy, T AF Thomas, Stephen Nisalak, Ananda Libraty, Daniel Sahasakmontri, Nongnard Kalayanarooj, Siripen Vaughn, David Putnak, Robert Endy, Timothy TI PERFORMANCE OF THE DENGUE PLAQUE REDUCTION NEUTRALIZATION TEST (PRNT) IN PRIMARY AND SECONDARY DENGUE VIRUS (DENV) INFECTIONS ACROSS A SPECTRUM OF TEST CONDITIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Thomas, Stephen; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Libraty, Daniel] Univ Massachusetts, Sch Med, Worcester, MA USA. [Sahasakmontri, Nongnard; Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Vaughn, David] GlaxoSmithKline Biol, King Of Prussia, PA USA. [Putnak, Robert] Walter Reed Army Inst Res, Silver Spring, MD USA. [Endy, Timothy] SUNY Upstate Med Univ, Syracuse, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 120 BP 36 EP 36 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600121 ER PT J AU Jarman, RG Klungthong, C Holmes, EC Chinnawirotpisan, P Rodpradit, P Pimgate, C Scott, TW Rothman, AL Yoon, IK Gibbons, RV AF Jarman, Richard G. Klungthong, Chonticha Holmes, Edward C. Chinnawirotpisan, Piyawan Rodpradit, Prinyada Pimgate, Chusak Scott, Thomas W. Rothman, Alan L. Yoon, In-Kyu Gibbons, Robert V. TI GENETIC ANALYSIS OF DENGUE VIRUSES COLLECTED FROM MOSQUITOES AND HUMANS DURING DENGUE CLUSTER INVESTIGATIONS IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Jarman, Richard G.; Klungthong, Chonticha; Chinnawirotpisan, Piyawan; Rodpradit, Prinyada; Pimgate, Chusak; Yoon, In-Kyu; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Holmes, Edward C.] Penn State Univ, University Pk, PA 16802 USA. [Scott, Thomas W.] Univ Calif Davis, Davis, CA 95616 USA. [Rothman, Alan L.] Univ Massachusetts, Sch Med, Worcester, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 125 BP 37 EP 37 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600126 ER PT J AU Vithessonthi, K Pancharoen, C Thisyakorn, C Nisalak, A Thisyakorn, U AF Vithessonthi, Kanyalak Pancharoen, Chitsanu Thisyakorn, Chule Nisalak, Ananda Thisyakorn, Usa TI SEROEPIDEMIOLOGY OF DENGUE VIRUS INFECTION IN HIV-INFECTED CHILDREN IN COMPARISON TO HEALTHY CHILDREN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Vithessonthi, Kanyalak; Pancharoen, Chitsanu; Thisyakorn, Chule; Thisyakorn, Usa] King Chulalongkorn Mem Hosp, Bangkok, Thailand. [Nisalak, Ananda] US Army Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 147 BP 44 EP 44 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600148 ER PT J AU Milhous, WK Gerena, L O'Neil, M Ahumada, A Hoffman, S AF Milhous, Wilbur K. Gerena, Lucia O'Neil, Mike Ahumada, Adriana Hoffman, Stephen TI CHEMOTHERAPEUTIC EVALUATION OF WHOLE CELL MALARIA VACCINE CANDIDATES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Milhous, Wilbur K.] Univ S Florida, Tampa, FL USA. [Gerena, Lucia; O'Neil, Mike] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ahumada, Adriana] Sanaria Inc, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 176 BP 52 EP 52 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600177 ER PT J AU Macareo, L Li, QG Smith, B Polhemus, M Miller, S AF Macareo, Louis Li, Qigui Smith, Bryan Polhemus, Mark Miller, Scott TI AREA UNDER THE EFFICACY CURVE ANALYSIS OF INTRAVENOUS ARTESUNATE IN TREATMENT OF SEVERE MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Macareo, Louis; Li, Qigui; Miller, Scott] Walter Reed Army Inst Res, Silver Spring, MD USA. [Smith, Bryan] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Polhemus, Mark] USA, Med Res Unit, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 178 BP 53 EP 53 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600179 ER PT J AU Li, QG Cantilena, LR Leary, KJ Saviolakis, GA Miller, RS Melendez, V Weina, PJ AF Li, Qigui Cantilena, Louis R. Leary, Kevin J. Saviolakis, George A. Miller, R. Scott Melendez, Victor Weina, Peter J. TI PHARMACOKINETIC EVALUATION OF ARTESUNATE FOLLOWING SINGLE INTRAVENOUS INJECTION OF 0.5, 1, 2, 4, AND 8 MG/KG IN NORMAL, HEALTHY VOLUNTEERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Li, Qigui; Miller, R. Scott; Melendez, Victor; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Cantilena, Louis R.; Leary, Kevin J.; Saviolakis, George A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 182 BP 54 EP 54 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600183 ER PT J AU Li, QG Weina, PJ AF Li, Qigui Weina, Peter J. TI COMPARTMENTAL MODEL-DEPENDENT ANALYSIS OF PHARMACOKINETIC DATA OF ARTESUNATE FOLLOWING SHORT-TERM INFUSION IN HEALTH VOLUNTEERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Li, Qigui; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 183 BP 54 EP 54 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600184 ER PT J AU Zhang, J Xie, LH Zeng, Q Peacock, E Li, QG O'Neil, MT AF Zhang, Jing Xie, Lisa H. Zeng, Qiang Peacock, Erin Li, Qigui O'Neil, Michael T. TI EFFECTS OF PLASMODIUM BERGHEI AND P. YOELII SPOROZOITE NUMBER ON IN VIVO INFECTION RATES AND TIME TO PATENCY IN C57BL/6 MICE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Zhang, Jing; Xie, Lisa H.; Zeng, Qiang; Peacock, Erin; Li, Qigui; O'Neil, Michael T.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 184 BP 54 EP 55 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600185 ER PT J AU Gu, YC Li, QG Meledez, V Weina, PJ AF Gu, Yuanchao C. Li, Qigui Meledez, Victor Weina, Peter J. TI COMPARISON OF HPLC WITH ELECTROCHEMICAL DETECTION AND LC-MS/MS FOR THE SEPARATION AND VALIDATION OF ARTESUNATE AND DIHYDROARTEMISININ IN ANIMAL AND HUMAN PLASMA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Gu, Yuanchao C.; Li, Qigui; Meledez, Victor; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 185 BP 55 EP 55 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600186 ER PT J AU Myint, HY Ohrt, C Sampath, A Walker, L White, N Magill, A AF Myint, Hla Y. Ohrt, Colin Sampath, Aruna Walker, Larry White, Nick Magill, Alan TI CLINICAL SAFETY AND DRUG INTERACTIONS WITH 8-AMINOQUINOLINES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Myint, Hla Y.; Ohrt, Colin; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sampath, Aruna; Walker, Larry] Univ Mississippi, University, MS 38677 USA. [White, Nick] Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok, Thailand. RI White, Nicholas/I-4629-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 188 BP 55 EP 56 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600189 ER PT J AU Xie, LH Li, QG Zhang, J Weina, PJ AF Xie, Lisa H. Li, Qigui Zhang, Jing Weina, Peter J. TI TISSUE DISTRIBUTION, METABOLIC PROFILES AND PROTEIN BINDING OF (C-14) DIHYDROARTEMISININ FOLLOWING SINGLE INTRAVENOUS ADMINISTRATION IN RATS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Xie, Lisa H.; Li, Qigui; Zhang, Jing; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 186 BP 55 EP 55 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600187 ER PT J AU Rothstein, Y Myer, J Dow, G Wasson, P Walker, L Magill, A Ohrt, CK AF Rothstein, Yarrow Myer, James Dow, Geoffrey Wasson, Peggy Walker, Larry Magill, Alan Ohrt, Colin K. TI EVIDENCE OF HEMOLYTIC ANEMIA IN TAFENOQUINE AND PRIMAQUINE ANIMAL STUDIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Rothstein, Yarrow; Dow, Geoffrey; Wasson, Peggy; Walker, Larry; Magill, Alan; Ohrt, Colin K.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Myer, James] GlaxoSmithKline Inc, Res Triangle Pk, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 189 BP 56 EP 56 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600190 ER PT J AU Zhu, GD Gao, Q Zhou, HY Li, JL Lu, F Liu, YB Jetsumon, S AF Zhu, Guoding Gao, Qi Zhou, Huayun Li, Julin Lu, Feng Liu, Yaobao Jetsumon, Sattabongkot TI SUSCEPTIBILITY OF PLASMODIUM VIVAX TO ANOPHELES ANTHROPOPHAGUS FROM DIFFERENT AREAS IN CHINA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Zhu, Guoding; Gao, Qi; Zhou, Huayun; Li, Julin; Lu, Feng; Liu, Yaobao] Jiangsu Inst Parasit Dis, Wuxi, Peoples R China. [Jetsumon, Sattabongkot] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 245 BP 72 EP 72 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600246 ER PT J AU Turell, MJ Wilson, WC Bennett, K AF Turell, Michael J. Wilson, William C. Bennett, Kristine TI POTENTIAL FOR NORTH AMERICAN MOSQUITOES TO TRANSMIT RIFT VALLEY FEVER VIRUS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Turell, Michael J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Wilson, William C.; Bennett, Kristine] ARS, USDA, Arthropod Borne Anim Dis Res Lab, Laramie, WY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 257 BP 75 EP 75 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600258 ER PT J AU Jeamwattanalert, P Ruang-Areerate, T Sunyakumthorn, P Mason, CJ Gaywee, J AF Jeamwattanalert, Pimmada Ruang-areerate, Toon Sunyakumthorn, Piyanate Mason, Carl J. Gaywee, Jariyanart TI GENETIC DIVERSITY OF ORIENTIA TSUTSUGAMUSHI FROM FEBRILE PATIENT IN UPPER REGIONS OF THAILAND DURING 2004-2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Jeamwattanalert, Pimmada; Ruang-areerate, Toon; Sunyakumthorn, Piyanate; Mason, Carl J.; Gaywee, Jariyanart] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 267 BP 78 EP 78 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600268 ER PT J AU Murray, CK Pimentel, G Parker, T Beckius, ML Samir, A Rhman, BA Mende, K Galloway, RL Hospenthal, DR AF Murray, Clinton K. Pimentel, Guillermo Parker, Tina Beckius, Miriam L. Samir, Ahmed Rhman, Bassern Abdel Mende, Katrin Galloway, Renee L. Hospenthal, Duane R. TI ANTIMICROBIAL SUSCEPTIBILITIES OF CLINICAL HUMAN ISOLATES OF LEPTOSPIRA FROM EGYPT SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Murray, Clinton K.; Beckius, Miriam L.; Hospenthal, Duane R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Pimentel, Guillermo; Rhman, Bassern Abdel] US NAMRU3, Cairo, Egypt. [Parker, Tina] NIH, Bethesda, MD 20892 USA. [Samir, Ahmed] Cairo Univ, Cairo, Egypt. [Mende, Katrin] Infect Dis Clin Res Program, Ft Sam Houston, TX USA. [Galloway, Renee L.] Ctr Dis Control & Prevent, Atlanta, GA USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 266 BP 78 EP 78 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600267 ER PT J AU Hinkle, MK Green, JA Martin, GJ Kochel, TJ Hall, ER Villaran, M Garcia, J Scott, P Bautista, CT Sateren, WB Gray, M Murray, CK Hospenthal, DR Maves, RC AF Hinkle, Mary K. Green, Justin A. Martin, Gregory J. Kochel, Tacleusz J. Hall, Eric R. Villaran, Manuel Garcia, Josefina Scott, Paul Bautista, Christian T. Sateren, Warren B. Gray, Michael Murray, Clinton K. Hospenthal, Duane R. Maves, Ryan C. TI SEROSURVEY OF LEPTOSPIROSIS IN PERUVIAN MILITARY PERSONNEL DEPLOYED TO HAITI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Hinkle, Mary K.; Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, San Antonio, TX USA. [Green, Justin A.; Kochel, Tacleusz J.; Hall, Eric R.; Villaran, Manuel; Garcia, Josefina; Maves, Ryan C.] Naval Med Res Ctr Detachment, Lima, Peru. [Martin, Gregory J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Scott, Paul; Bautista, Christian T.; Sateren, Warren B.] Walter Reed Army Inst Res, Rockville, MD USA. RI Bautista, Christian/B-2812-2011 NR 0 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 269 BP 79 EP 79 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600270 ER PT J AU Woodring, JV Srijan, A Mason, C AF Woodring, Joseph V. Srijan, Apichai Mason, Carl TI PREVALENCE OF VIBRIO, AEROMONAS AND SALMONELLA SPECIES IN VARIOUS SEAFOODS FROM SUPERMARKETS AND FRESH MARKETS IN BANGKOK, THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Woodring, Joseph V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Srijan, Apichai; Mason, Carl] USA, Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 270 BP 79 EP 79 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600271 ER PT J AU Robertson, JL Becker, SJ Yu, X Hawley, JA Griffith, ME Bekius, ML Hospenthal, DR Mende, K Murray, CK AF Robertson, Jainelle L. Becker, Sara J. Yu, Xin Hawley, Joshua A. Griffith, Matthew E. Bekius, Miriam L. Hospenthal, Duane R. Mende, Katrin Murray, Clinton K. TI DETECTION OF LEPTOSPIRAL DNA FROM INOCULATED BLOOD AND URINE SAMPLES USING FIVE PCR PRIMERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Robertson, Jainelle L.; Becker, Sara J.; Hawley, Joshua A.; Griffith, Matthew E.; Hospenthal, Duane R.; Murray, Clinton K.] Brooke Army Med Ctr, San Antonio, TX USA. [Yu, Xin; Bekius, Miriam L.; Mende, Katrin] Infect Dis Clin Res Program, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 275 BP 80 EP 80 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600276 ER PT J AU Schoepp, RJ McKinney, MD Moon, SJ Kulesh, DA Larsen, T AF Schoepp, Randal J. McKinney, Michelle D. Moon, Steven J. Kulesh, David A. Larsen, Thomas TI DETECTION OF VIRAL RNA FROM PARAFFIN-EMBEDDED TISSUES AFTER PROLONGED FORMALIN FIXATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Schoepp, Randal J.; Moon, Steven J.; Kulesh, David A.; Larsen, Thomas] USA, Med Res Inst Infect Dis, Frederick, MD USA. [McKinney, Michelle D.] Geocenters Inc, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 314 BP 92 EP 92 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600314 ER PT J AU Dent, AE Bergmann-Leitner, E Wilson, D Tisch, D Kimmel, R Vulule, J Sumba, P Beeson, J Angov, E Moormann, A Kazura, J AF Dent, Arlene E. Bergmann-Leitner, Elke Wilson, Danny Tisch, Daniel Kimmel, Rhonda Vulule, John Sumba, Peter Beeson, James Angov, Evelina Moormann, Ann Kazura, James TI IMMUNITY TO PLASMODIUM FALCIPARUM MEASURED BY GROWTH INHIBITION ASSAY DECREASES WITH AGE AND IS ASSOCIATED WITH DELAYED TIME TO BLOOD STAGE INFECTION IN NATURALLY EXPOSED PERSONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Dent, Arlene E.; Tisch, Daniel; Moormann, Ann; Kazura, James] Case Western Reserved Univ, Cleveland, OH USA. [Bergmann-Leitner, Elke; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wilson, Danny; Beeson, James] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia. [Kimmel, Rhonda] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Vulule, John; Sumba, Peter] Kenya Govt Med Res Ctr, Kisumu, Kenya. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 326 BP 95 EP 96 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600326 ER PT J AU Kayatani, AK Fukuda, MM Leke, RG Taylor, DW AF Kayatani, Alexander K. Fukuda, Mark M. Leke, Rose G. Taylor, Diane W. TI COMPARISON OF SEROLOGICAL PROFILES AND ANTIBODY AVIDITIES TO EIGHT MAJOR CANDIDATE VACCINE ANTIGENS IN THAI AND CAMEROON ADULTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kayatani, Alexander K.; Taylor, Diane W.] Univ Hawaii, Honolulu, HI 96822 USA. [Fukuda, Mark M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Leke, Rose G.] Univ Yaounde 1, Yaounde, Cameroon. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 327 BP 96 EP 96 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600327 ER PT J AU Cummings, DA Iamsirithaworn, S Lessler, J Prasanthong, R Jarman, RG Burke, DS Gibbons, RV AF Cummings, Derek A. Iamsirithaworn, Sopon Lessler, Justin Prasanthong, Rungnapa Jarman, Richard G. Burke, Donald S. Gibbons, Robert V. TI DENGUE AND THE DEMOGRAPHIC TRANSITION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Cummings, Derek A.; Lessler, Justin] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Iamsirithaworn, Sopon; Prasanthong, Rungnapa] Minist Publ Hlth, Nonthaburi, Thailand. [Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Burke, Donald S.] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 385 BP 113 EP 114 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600385 ER PT J AU Libraty, DH Capeding, RM Acosta, L Tallo, V Mercado, E Bautista, A Jarman, RG Yoon, IK Gibbons, RV Brion, JD AF Libraty, Daniel H. Capeding, Rosario M. Acosta, Luz Tallo, Veronica Mercado, Edel Bautista, Analisa Jarman, Richard G. Yoon, In-Kyu Gibbons, Robert V. Brion, Job D. TI A PROSPECTIVE STUDY OF PRIMARY DENGUE VIRUS INFECTIONS DURING INFANCY: PRELIMINARY FINDINGS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Libraty, Daniel H.] Univ Massachusetts, Sch Med, Worcester, MA USA. [Capeding, Rosario M.; Acosta, Luz; Tallo, Veronica; Mercado, Edel; Bautista, Analisa] Res Inst Trop Med, Manila, Philippines. [Jarman, Richard G.; Yoon, In-Kyu; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Brion, Job D.] San Pablo City Hlth Off, San Pablo, Philippines. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 389 BP 115 EP 115 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600389 ER PT J AU Kosoy, MY Bai, Y Lerdthusnee, K Richardson, JH Boonmar, S Peruski, LF Suttirattana, S Maloney, SA AF Kosoy, Michael Y. Bai, Ying Lerdthusnee, Kriangkrai Richardson, Jason H. Boonmar, Sumalee Peruski, Leonard F. Suttirattana, Saithip Maloney, Susan A. TI PHYLOGENETIC RELATIONS BETWEEN BARTONELLA STRAINS IDENTIFIED IN ANIMALS AND HUMANS FROM THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kosoy, Michael Y.; Bai, Ying] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Lerdthusnee, Kriangkrai; Richardson, Jason H.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Boonmar, Sumalee] Kasetsart Univ, Fac Med Vet, Bangkok, Thailand. [Peruski, Leonard F.; Suttirattana, Saithip; Maloney, Susan A.] Thailand MOPH US CDC Collaborat, Int Emerging Infect Program, Nonthaburi, Thailand. RI Richardson, Jason/A-9441-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 416 BP 123 EP 123 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600416 ER PT J AU Deye, G Remich, S Ntoburi, S Cook, E Apollo, D House, B Ohrt, C AF Deye, Gregory Remich, Shon Ntoburi, Stephen Cook, Earnest Apollo, Duncan House, Brent Ohrt, Colin TI THE USE OF ANTI-MSP1 ELISA TO IDENTIFY NON-IMMUNE INDIVIDUALS FOR INCLUSION IN MALARIA PROPHYLAXIS TRIALS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Deye, Gregory; House, Brent; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Remich, Shon] Walter Reed Army Med Ctr, Silver Spring, MD USA. [Ntoburi, Stephen] Wellcome Trust Res Programme, Kenya Med Res Inst, Nairobi, Kenya. [Cook, Earnest; Apollo, Duncan] Kenya Govt Med Res Ctr, Clin Res Ctr, Malaria Diagnost Ctr Excellence, Kisumu, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 458 BP 135 EP 135 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600457 ER PT J AU Sharlow, ER Grieser, H Yellow-Duke, A Leimgruber, S Close, D Barrett, R Johnson, J O'Neil, M Magill, A Lazo, JS AF Sharlow, Elizabeth R. Grieser, Heather Yellow-Duke, Archibong Leimgruber, Stephanie Close, David Barrett, Rebecca Johnson, Jacob O'Neil, Michael Magill, Alan Lazo, John S. TI DEVELOPMENT AND IMPLEMENTATION OF A LIFE CYCLE-DEPENDENT, PHENOTYPIC HIGH THROUGHPUT LEISHMANIA MAJOR PROMASTIGOTE DRUG SUSCEPTIBILITY ASSAYS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Sharlow, Elizabeth R.; Lazo, John S.] Univ Pittsburgh, Drug Discovery Inst, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA. [Johnson, Jacob; O'Neil, Michael; Magill, Alan] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 472 BP 139 EP 139 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600471 ER PT J AU Potts, JA Kalayanarooj, S Nimmannitya, S Srikiatkhachorn, A Nisalak, A Vaughn, DW Endys, TP Libraty, DH Green, S Rothman, AL AF Potts, James A. Kalayanarooj, Siripen Nimmannitya, Suchitra Srikiatkhachorn, Anon Nisalak, Ananda Vaughn, David W. Endys, Timothy P. Libraty, Daniel H. Green, Sharone Rothman, Alan L. TI CLASSIFICATION AND REGRESSION TREE (CART) ANALYSIS USING CLINICAL LABORATORY VARIABLES KNOWN TO BE ASSOCIATED WITH DENGUE TO ESTABLISH EARLY DISEASE CLASSIFICATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Potts, James A.; Srikiatkhachorn, Anon; Libraty, Daniel H.; Green, Sharone; Rothman, Alan L.] Univ Massachusetts, Sch Med, Worcester, MA USA. [Kalayanarooj, Siripen; Nimmannitya, Suchitra] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Vaughn, David W.] USA, Med Res & Mat Command, Ft Detrick, MD USA. [Endys, Timothy P.] Upstate Med Univ, NYU, Syracuse, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 484 BP 143 EP 143 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600483 ER PT J AU Haraoui, LP Koles, N Howard, RS Wortmann, GW Polhemus, M Aronson, NE AF Haraoui, Louis-Patrick Koles, Nancy Howard, Robin S. Wortmann, Glenn W. Polhemus, Mark Aronson, Naomi E. TI SERUM NITRIC OXIDE (NO) LEVELS IN CUTANEOUS LEISHMANIASIS (CL): CORRELATIONS WITH TREATMENT OUTCOME AND THE ADVERSE EVENT OF PANCREATITIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Haraoui, Louis-Patrick] McGill Univ, Dept Med, Internal Med Residency Training Program, Montreal, PQ, Canada. [Koles, Nancy; Aronson, Naomi E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Howard, Robin S.; Wortmann, Glenn W.; Polhemus, Mark] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 544 BP 160 EP 160 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600543 ER PT J AU Sampath, A Tekwani, B Rochford, R Ray, P Friedman, J McMillan, D Bhonsle, J Rothstein, Y Magill, A Walker, L Ohrt, C AF Sampath, Aruna Tekwani, Babu Rochford, Rosemary Ray, Prabhati Friedman, Jeffery McMillan, David Bhonsle, Jayendra Rothstein, Yarrow Magill, Alan Walker, Larry Ohrt, Colin TI IDENTIFICATION OF MODELS TO PREDICT A NON-HEMOLYTIC 8-AMINOQUINOLINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Sampath, Aruna; Tekwani, Babu; Walker, Larry] Univ Mississippi, University, MS 38677 USA. [Rochford, Rosemary] SUNY Upstate Med Univ, Syracuse, NY USA. [Ray, Prabhati; Bhonsle, Jayendra; Rothstein, Yarrow; Magill, Alan; Ohrt, Colin] Walter Reed Army Inst Res, Silver Spring, MD USA. [Friedman, Jeffery] Scripps Res Inst, La Jolla, CA USA. [McMillan, David] Univ Nebraska Med Ctr, Omaha, NE USA. RI Bhonsle, Jayendra/A-9139-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 581 BP 171 EP 172 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600580 ER PT J AU Gutteridge, CE Major, JW Nin, DA Bhattacharjee, AK Gerena, L AF Gutteridge, Clare E. Major, Joshua W. Nin, Daniel A. Bhattacharjee, Apurba K. Gerena, Lucia TI ANTIMALARIAL ACTIVITY OF ARYL-SUBSTITUTED 2-ETHOXYACETAMIDES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Gutteridge, Clare E.; Major, Joshua W.; Nin, Daniel A.] USN Acad, Annapolis, MD USA. [Bhattacharjee, Apurba K.; Gerena, Lucia] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 583 BP 172 EP 172 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600582 ER PT J AU Saunders, D Kozar, M Victor, M Li, QQ Teja-Isavadharm, P Montip, G O'Neill, M Ohrt, C Magill, A Lin, AJ AF Saunders, David Kozar, Michael Victor, Melendez Li, Qiqui Teja-Isavadharm, Paktiya Montip, Gettayacamin O'Neill, Michael Ohrt, Colin Magill, Alan Lin, Ai J. TI PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS OF IMIDAZOLIDINEDIONE DERIVATIVES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Saunders, David; Kozar, Michael; Victor, Melendez; Li, Qiqui; Teja-Isavadharm, Paktiya; Montip, Gettayacamin; O'Neill, Michael; Ohrt, Colin; Magill, Alan; Lin, Ai J.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Kozar, Michael/A-9155-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 589 BP 174 EP 174 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644600588 ER PT J AU Bergmann-Leitner, ES Mease, RM Laquer, KM Duncan, EH Savranskaya, T Williams, JL Ockenhouse, CF Angov, E AF Bergmann-Leitner, Elke S. Mease, Ryan M. Laquer, Kari M. Duncan, Elizabeth H. Savranskaya, Tatiana Williams, Jack L. Ockenhouse, Christian F. Angov, Evelina TI EVALUATION OF HUMORAL AND CELLULAR RESPONSES INDUCED BY PLASMODIUM BERGHEI CELTOS ADMINISTERED BY RECOMBINANT PROTEIN AND GENE-GUN DELIVERY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Bergmann-Leitner, Elke S.; Mease, Ryan M.; Laquer, Kari M.; Duncan, Elizabeth H.; Savranskaya, Tatiana; Williams, Jack L.; Ockenhouse, Christian F.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 643 BP 190 EP 190 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601008 ER PT J AU McGrath, S Cummings, J Kortepeter, M Nielsen, R Tierney, E Ware, L Ofori-Anyinam, O Dutta, S Lanar, D Sedegah, M Kester, K Malkin, E Diggs, C Soisson, L Dubois, MC Ballou, R Cohen, J Krzych, U Ockenhouse, C Heppner, G Spring, M AF McGrath, Shannon Cummings, James Kortepeter, Mark Nielsen, Robin Tierney, Ev Ware, Lisa Ofori-Anyinam, Opokua Dutta, Sheetij Lanar, David Sedegah, Martha Kester, Kent Malkin, Elissa Diggs, Carter Soisson, Lorraine Dubois, Marie-Claude Ballou, Ripley Cohen, Joe Krzych, Urszula Ockenhouse, Chris Heppner, Gray Spring, Michele TI MULTI-FUNCTIONAL T-CELL RESPONSES INDUCED BY THE AS01 OR AS02 ADJUVANTED MALARIA VACCINE CANDIDATE APICAL MEMBRANE ANTIGEN-1 (AMA-1) ADMINISTERED TO MALARIA-NAIVE ADULTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [McGrath, Shannon; Cummings, James; Nielsen, Robin; Ware, Lisa; Dutta, Sheetij; Lanar, David; Sedegah, Martha; Krzych, Urszula; Ockenhouse, Chris; Heppner, Gray; Spring, Michele] US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Kortepeter, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Tierney, Ev; Malkin, Elissa] PATH Malaria Vaccine Initiat, Bethesda, MD USA. [Ofori-Anyinam, Opokua; Dubois, Marie-Claude; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Kester, Kent] Walter Reed Army Inst Res, Silver Spring, MD USA. [Diggs, Carter; Soisson, Lorraine] US Agcy Int Dev, Washington, DC 20523 USA. [Ballou, Ripley] Bill & Melinda Gates Fdn, Seattle, WA USA. RI Kester, Kent/A-2114-2011; Lanar, David/B-3560-2011 OI Kester, Kent/0000-0002-5056-0802; NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 646 BP 191 EP 191 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601011 ER PT J AU Spring, M Bergmann-Leitner, E James, C House, B Krzych, U Tosh, D Miller, L Ware, L Godeaux, O Dubois, MC Lyons, J Ballou, R Soisson, L Diggs, C Cohen, J Heppner, G Ockenhouse, C Angov, E AF Spring, Michele Bergmann-Leitner, Elke James, Cummings House, Brent Krzych, Urszula Tosh, Donna Miller, Lori Ware, Lisa Godeaux, Olivier Dubois, Marie-Claude Lyons, Jeffrey Ballou, Ripley Soisson, Lorraine Diggs, Carter Cohen, Joe Heppner, Gray Ockenhouse, Chris Angov, Evelina TI PHASE 1A OPEN-LABEL DOSE ESCALATION STUDY TO EVALUATE THE SAFETY, REACTOGENICITY, AND IMMUNOGENICITY OF THE CANDIDATE PLASMODIUM FALCIPARUM MEROZOITE SURFACE PROTEIN-1 (MSP-1(42)) ADMINISTERED INTRAMUSCULARLY WITH GSK BIOLOGICALS' ADJUVANT SYSTEM AS01B IN HEALTHY MALARIA-NAIVE ADULTS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Spring, Michele; Bergmann-Leitner, Elke; James, Cummings; House, Brent; Krzych, Urszula; Tosh, Donna; Ware, Lisa; Heppner, Gray; Ockenhouse, Chris; Angov, Evelina] US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Miller, Lori; Lyons, Jeffrey] Walter Reed Army Inst Res, Silver Spring, MD USA. [Godeaux, Olivier; Dubois, Marie-Claude; Cohen, Joe] GlaxoSmithKline Biol, Rixensart, Belgium. [Ballou, Ripley] Bill & Melinda Gates Fdn, Seattle, WA USA. [Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Washington, DC 20523 USA. RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 647 BP 191 EP 192 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601012 ER PT J AU Brando, C Kaba, S Guo, Q Steele, M Mittelholzer, C Raman, S Burkhard, P Lanar, DE AF Brando, Clara Kaba, Stephen Guo, Qin Steele, Molly Mittelholzer, Christian Raman, Senthilkumar Burkhard, Peter Lanar, David E. TI ADJUVANT AND CARRIER EFFECT OF SELF-ASSEMBLING POLYPEPTIDE NANOPARTICLES (SAPN) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Brando, Clara; Kaba, Stephen; Guo, Qin; Steele, Molly; Lanar, David E.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Mittelholzer, Christian; Raman, Senthilkumar] ME Muller Inst Biomech, Basel, Switzerland. [Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT USA. RI Kaba, Stephen/B-3555-2011; Lanar, David/B-3560-2011 OI Kaba, Stephen/0000-0003-1509-2975; NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 648 BP 192 EP 192 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601013 ER PT J AU Lascano, M Leistner, C Wojno, A Romoser, M Dohm, D Trudel, R Tomc, C Romoser, WS AF Lascano, Mauricio Leistner, Christine Wojno, Abbey Romoser, Margaret Dohm, David Trudel, Richard Tomc, Christa Romoser, William S. TI CHARACTERIZATION OF WATER-HOLDING CONTAINERS AS MOSQUITO-HABITATS, AND DENGUE-PREVENTION COMMUNITY EDUCATION IN RURAL ECUADORIAN COMMUNITIES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Lascano, Mauricio; Romoser, William S.] Ohio Univ, Coll Osteopath Med, Trop Dis Inst, Athens, OH 45701 USA. [Leistner, Christine] Ohio Univ, Int Dev Studies, Athens, OH 45701 USA. [Wojno, Abbey; Romoser, Margaret] Ohio Univ, Scripps Coll Commun, Commun Studies, Athens, OH 45701 USA. [Dohm, David] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Trudel, Richard] SOPFIM, Soc Protec Forets Insectes & Maladies, Quebec City, PQ, Canada. [Tomc, Christa] Ohio Univ, Coll Osteopath Med, Athens, OH 45701 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 695 BP 204 EP 205 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601060 ER PT J AU Vaughan, JA Mehus, JO Bell, JA Turell, MJ AF Vaughan, Jefferson A. Mehus, Joseph O. Bell, Jeffrey A. Turell, Michael J. TI MICROFILARIAL UPTAKE AND PENETRATION OF THE MIDGUT AMONG DIFFERENT MOSQUITO SPECIES FED SIMULTANEOUSLY ON THE SAME MICROFILAREMIC HOST SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Vaughan, Jefferson A.; Mehus, Joseph O.; Bell, Jeffrey A.] Univ N Dakota, Grand Forks, ND 58201 USA. [Turell, Michael J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 696 BP 205 EP 205 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601061 ER PT J AU Brown, TR Martinez, LJ Llanos, JK Lynch, JA Coldren, RL AF Brown, Theodore R. Martinez, Luis J. Llanos, Joseph K. Lynch, Julia A. Coldren, Rodney L. TI ADENOVIRUS 21 OUTBREAK AT THE COAST GUARD TRAINING CENTER IN CAPE MAY, NEW JERSEY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Brown, Theodore R.; Llanos, Joseph K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Martinez, Luis J.; Lynch, Julia A.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Coldren, Rodney L.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 700 BP 206 EP 206 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601065 ER PT J AU Coberly, JS Wojcik, R Chretien, JP Lewis, S AF Coberly, Jacqueline S. Wojcik, Richard Chretien, Jean-Paul Lewis, Sheri TI SURVEILLANCE OF EMERGING DISEASE IN RESOURCE LIMITED SETTINGS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Coberly, Jacqueline S.; Wojcik, Richard; Lewis, Sheri] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD USA. [Chretien, Jean-Paul] Walter Reed Army Inst Res, Global Emerging Infect Syst, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 710 BP 209 EP 209 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601075 ER PT J AU Fair, J Guttieri, M Branco, L Geske, J Khan, H Schoepp, R Goba, A Geisbert, J Garry, R Bausch, D AF Fair, Joseph Guttieri, Mary Branco, Luis Geske, Jon Khan, Humarr Schoepp, Randal Goba, Augustine Geisbert, Joan Garry, Robert Bausch, Daniel TI DEVELOPMENT AND EVALUATION OF RECOMBINANT ARENAVIRUS PROTEINS FOR USE IN DIAGNOSTIC, PROPHYLACTIC AND THERAPEUTIC APPLICATIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Fair, Joseph; Garry, Robert; Bausch, Daniel] Tulane Univ, New Orleans, LA 70118 USA. [Guttieri, Mary; Schoepp, Randal] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Branco, Luis] Biofactura INC, Rockville, MD USA. [Geske, Jon] Corgenix, Denver, CO USA. [Khan, Humarr; Goba, Augustine] Kenema Govt Hosp, Kenema, Sierra Leone. [Geisbert, Joan] Boston Univ, Boston, MA 02215 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 714 BP 210 EP 211 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601079 ER PT J AU Martin, SS Parker, MD Bakken, R Price, JL Hart, MK Fine, DL AF Martin, Shannon S. Parker, Michael D. Bakken, Russell Price, Jessica L. Hart, Mary Kate Fine, Donald L. TI DETECTION OF FEBRILE RESPONSES IN VENEZUELAN EQUINE ENCEPHALITIS VIRUS (VEEV) INFECTED MICE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Martin, Shannon S.; Price, Jessica L.; Hart, Mary Kate; Fine, Donald L.] DynPort Vaccine Co, Frederick, MD USA. [Parker, Michael D.; Bakken, Russell] USA, Med Res Inst Infect Dis, Frederick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 720 BP 212 EP 212 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601085 ER PT J AU Scott, TW Carey, JR Fansiri, T Richardson, J AF Scott, Thomas W. Carey, James R. Fansiri, Thanyalak Richardson, Jason TI A RESIDUAL DEMOGRAPHY METHOD FOR ESTIMATING AGE STRUCTURE OF WILD MOSQUITO VECTOR POPULATIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Scott, Thomas W.; Carey, James R.] Univ Calif Davis, Davis, CA 95616 USA. [Fansiri, Thanyalak; Richardson, Jason] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RI Richardson, Jason/A-9441-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 734 BP 217 EP 217 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601099 ER PT J AU Kelly, JX Smilkstein, M Melendez, V Cooper, R Winter, R Hinrichs, D Riscoe, M AF Kelly, Jane X. Smilkstein, Martin Melendez, Victor Cooper, Roland Winter, Rolf Hinrichs, Dave Riscoe, Mike TI OPTIMIZATION OF DUAL-FUNCTION ACRIDONE ANTIMALARIALS: IMPROVED EFFICACY AND SYNERGY WITH PIPERAQUINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Kelly, Jane X.; Smilkstein, Martin; Winter, Rolf; Hinrichs, Dave; Riscoe, Mike] Portland VA Med Ctr, Portland, OR USA. [Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD USA. [Cooper, Roland] Old Dominion Univ, Norfolk, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 760 BP 224 EP 224 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601125 ER PT J AU Smith, BL Polhemus, ME Jongsakul, K Ogutu, B Weina, PJ Miller, RS AF Smith, Bryan L. Polhemus, Mark E. Jongsakul, Krisada Ogutu, Bernhards Weina, Peter J. Miller, R. Scott TI PHASE II, RANDOMIZED, OPEN-LABEL, DOSE-RANGING STUDY OF GMP INTRAVENOUS ARTESUNATE FOR OPTIMIZING PARASITE CLEARANCE IN UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Smith, Bryan L.; Polhemus, Mark E.; Weina, Peter J.; Miller, R. Scott] Walter Reed Army Inst Res, Silver Spring, MD USA. [Jongsakul, Krisada] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Ogutu, Bernhards] USA, Med Res Unit Kenya, Nairobi, Kenya. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 763 BP 225 EP 225 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601128 ER PT J AU Gaywee, J Sirisopana, N Eamsila, C Watcharapichat, P Chuenchitra, T Vudtakanok, J Jangyodsuk, V Boonlikit, S Srichantrapunt, W Paonin, S Pattanarangsan, R Arthayapan, T Bodhidatta, L Jarman, RG Pavlin, JA Mason, CJ AF Gaywee, Jariyanart Sirisopana, Narongrid Eamsila, Chirapa Watcharapichat, Pochaman Chuenchitra, Thippawan Vudtakanok, Judpon Jangyodsuk, Vim Boonlikit, Smin Srichantrapunt, Wisuth Paonin, Surat Pattanarangsan, Rattaporn Arthayapan, Thongdang Bodhidatta, Ladaporn Jarman, Richard G. Pavlin, Julie A. Mason, Carl J. TI RESPIRATORY DISEASE SURVEILLANCE IN 6 ROYAL THAI ARMY HOSPITALS ALONG THAI BORDERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Gaywee, Jariyanart; Sirisopana, Narongrid; Eamsila, Chirapa; Watcharapichat, Pochaman; Chuenchitra, Thippawan; Bodhidatta, Ladaporn; Jarman, Richard G.; Pavlin, Julie A.; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Vudtakanok, Judpon] Ft Surasi Hosp, Kanchanaburi, Thailand. [Jangyodsuk, Vim; Boonlikit, Smin] Ft Surasinghanath Hosp, Sa Kaew, Thailand. [Srichantrapunt, Wisuth] Ft Sunpasitthiprasong Hosp, Ubon Ratchathani, Thailand. [Paonin, Surat] Ft Mengraimaharat Hosp, Chiangrai, Thailand. [Pattanarangsan, Rattaporn] Ft Khetudomsak Hosp, Chumphon, Thailand. [Arthayapan, Thongdang] Ft Ingkayuthaborihan Hosp, Pattani, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 801 BP 236 EP 237 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601166 ER PT J AU Narum, DL Haynes, JD Moch, JK Dutta, S AF Narum, David L. Haynes, J. David Moch, J. Kathleen Dutta, Sheetij TI ISOLATION OF INVASIVE LONG LIVED PLASMODIUM FALCIPARUM MEROZOITES BY CELL SIEVING SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Narum, David L.] Natl Inst Hlth, Rockville, MD USA. [Haynes, J. David; Moch, J. Kathleen; Dutta, Sheetij] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 839 BP 247 EP 248 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601204 ER PT J AU Anderson, KB Chunsuttiwat, S Nisalak, A Jarman, RG Libraty, DH Srikiatkhachorn, A Mammen, MP Rothman, AL Gibbons, RV Endy, TP AF Anderson, Kathryn B. Chunsuttiwat, Supamit Nisalak, Ananda Jarman, Richard G. Libraty, Daniel H. Srikiatkhachorn, Anon Mammen, Mammen P., Jr. Rothman, Alan L. Gibbons, Robert V. Endy, Timothy P. TI PATTERNS OF CROSS-REACTIVITY AND SPECIFICITY IN THE SEROLOGICAL RESPONSE TO DENGUE INFECTION IN KAMPHAENG PHET, THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Anderson, Kathryn B.] Emory Univ, Atlanta, GA 30322 USA. [Chunsuttiwat, Supamit] Minist Publ Hlth, Dept Dis Control, Bangkok, Thailand. [Nisalak, Ananda; Jarman, Richard G.; Srikiatkhachorn, Anon; Mammen, Mammen P., Jr.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Libraty, Daniel H.; Rothman, Alan L.] Univ Massachusetts, Sch Med, Worcester, MA USA. [Endy, Timothy P.] Upstate Med Univ, Syracuse, NY USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 891 BP 262 EP 262 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601256 ER PT J AU Ghosh, K Mendez, J Braig, HR Weina, PJ AF Ghosh, Kashinath Mendez, Juan Braig, Henk R. Weina, Peter J. TI GENETIC POLYMORPHISM IN THE VISCERALIZING GENE SEQUENCE OF LEISHMANIA TROPICA ISOLATED FROM THE SOLDIERS RETURNING FROM IRAQ SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Ghosh, Kashinath; Mendez, Juan; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Braig, Henk R.] Bangor Univ, Sch Biol Sci, Bangor, Wales. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 925 BP 272 EP 272 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601290 ER PT J AU Dow, GS Chen, YF Andrews, KT Gerena, L Gettayacamin, M Johnson, J Li, Q Melendez, V Obaldia, N Tran, TN Kozikowski, A AF Dow, Geoffrey S. Chen, Yufeng Andrews, Katherine T. Gerena, Lucia Gettayacamin, Montip Johnson, Jacob Li, Qigui Melendez, Victor Obaldia, Nicanor, III Tran, Thanh N. Kozikowski, Alan TI ANTIMALARIAL ACTIVITY OF PHENYLTHIAZOLYL-HYDROXAMATE-BASED HISTONE DEACETYLASE INHIBITORS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Dow, Geoffrey S.; Gerena, Lucia; Johnson, Jacob; Li, Qigui; Melendez, Victor] Walter Reed Army Inst Res, Silver Spring, MD USA. [Chen, Yufeng] Univ Illinois, Chicago, IL USA. [Andrews, Katherine T.; Tran, Thanh N.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Gettayacamin, Montip] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Obaldia, Nicanor, III] Gorgas Mem Inst, Panama City, Panama. RI Obaldia, Nicanor/O-8460-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 970 BP 285 EP 285 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601335 ER PT J AU Tucker, K Diggs, C Heppner, DG Malkin, E Ockenhouse, CF Ogutu, BR Polhemus, ME Soisson, LA Withers, MR Wittes, J AF Tucker, Kathryn Diggs, Carter Heppner, D. Gray Malkin, Elissa Ockenhouse, Christian F. Ogutu, Bernhards R. Polhemus, Mark E. Soisson, Lorraine A. Withers, Mark R. Wittes, Janet TI MALARIA SLIDE-READING FOR QUANTITATION OF PARASITEMIA IN MALARIA INTERVENTION TRIALS: A BETTER TRANSITION POINT FROM THICK TO THIN FILMS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Tucker, Kathryn; Wittes, Janet] Stat Collaborat Inc, Washington, DC USA. [Diggs, Carter; Soisson, Lorraine A.] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA. [Heppner, D. Gray; Ockenhouse, Christian F.; Polhemus, Mark E.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Malkin, Elissa] PATH Malaria Vaccine Initiat, Bethesda, MD USA. [Ogutu, Bernhards R.] Kenya Govt Med Res Ctr, US Army Med Res Unit Kenya, Nairobi, Kenya. [Ogutu, Bernhards R.] Kenya Govt Med Res Ctr, Clin Res Ctr, Nairobi, Kenya. [Withers, Mark R.] USA, Med Res Inst Infect Dis, Div Med, Operat Med Dept, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 969 BP 285 EP 285 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601334 ER PT J AU Schiehser, GA Terpinski, J Ager, AL McGill, AJ Milhous, WK Kyle, DE Edstein, MD Rieckmann, KH Shanks, GD Sibley, CH Canfield, CJ Jacobus, LR Jacobus, DP AF Schiehser, Guy A. Terpinski, Jacek Ager, Arba L. McGill, Alan J. Milhous, Wilbur K. Kyle, Dennis E. Edstein, Michael D. Rieckmann, Karl H. Shanks, G. Dennis Sibley, Carol H. Canfield, Craig J. Jacobus, Laura R. Jacobus, David P. TI PRE-CLINICAL MOUSE TOXICITY STUDY OF THE THIRD GENERATION ANTIFOLATE, JPC-2056-I SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Schiehser, Guy A.; Terpinski, Jacek; Jacobus, Laura R.; Jacobus, David P.] Jacobus Pharmaceut Co Inc, Princeton, NJ USA. [Ager, Arba L.] Univ Miami, Sch Med, Miami, FL USA. [McGill, Alan J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Milhous, Wilbur K.; Kyle, Dennis E.] Univ S Florida, Tampa, FL USA. [Edstein, Michael D.; Rieckmann, Karl H.; Shanks, G. Dennis] Australiam Army Malaria Inst, Enoggera, Australia. [Sibley, Carol H.] Univ Washington, Seattle, WA 98195 USA. [Canfield, Craig J.] Pharmaceut Syst Inc, Talent, OR USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 973 BP 286 EP 286 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601338 ER PT J AU Jin, XN Sousa, J Carroll, D Olmeda, R Reese, N Asher, C Anova, L Kozar, MF Melendez, V AF Jin, Xiannu Sousa, Jason Carroll, Dustin Olmeda, Raul Reese, Necole Asher, Constance Anova, Lalaine Kozar, Michael F. Melendez, Victor TI IN VITRO HEPATIC METABOLISM STUDIES OF PRIMAQUINE AND RELATED ANTIMALARIAL COMPOUNDS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Jin, Xiannu; Sousa, Jason; Carroll, Dustin; Olmeda, Raul; Reese, Necole; Asher, Constance; Anova, Lalaine; Kozar, Michael F.; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RI Kozar, Michael/A-9155-2011; Sousa, Jason/A-9177-2011 NR 0 TC 0 Z9 0 U1 2 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 978 BP 287 EP 287 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601343 ER PT J AU Sousa, J Milner, E Jin, XN Kozar, MF McCalmont, W Lanteri, C Asher, C Olmeda, R Carroll, D Reese, N Anova, L Roncal, N Gerena, L Obaldia, N Dow, G Melendez, V AF Sousa, Jason Milner, Erin Jin, Xiannu Kozar, Michael F. McCalmont, William Lanteri, Charlotte Asher, Constace Olmeda, Raul Carroll, Dustin Reese, Necole Anova, Lalaine Roncal, Normal Gerena, Lucia Obaldia, Nicanor Dow, Geoffrey Melendez, Victor TI IN VITRO AND IN VIVO EVALUATIONS OF NEW QUINOLINE METHANOL ANALOGS OF MEFLOQUINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Sousa, Jason; Milner, Erin; Jin, Xiannu; Kozar, Michael F.; McCalmont, William; Lanteri, Charlotte; Asher, Constace; Olmeda, Raul; Carroll, Dustin; Reese, Necole; Anova, Lalaine; Roncal, Normal; Gerena, Lucia; Dow, Geoffrey; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Obaldia, Nicanor] Trop Med Res Gorgas Mem Res Inst, Panama City, Panama. RI Kozar, Michael/A-9155-2011; Sousa, Jason/A-9177-2011; Obaldia, Nicanor/O-8460-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 979 BP 287 EP 287 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601344 ER PT J AU Akala, H Eyase, F Omondi, A Cheruiyot, A Waitumbi, J Polhemus, M Ogutu, B Waters, N Johnson, J Schnabel, D Walsh, D AF Akala, Hoseah Eyase, Fred Omondi, Angela Cheruiyot, Agnes Waitumbi, John Polhemus, Mark Ogutu, Bernhards Waters, Norman Johnson, Jacob Schnabel, David Walsh, Douglas TI IN VITRO ANTIMALARIAL DRUG SENSITIVITY TRENDS IN KENYAN PLASMODIUM FALCIPARIUM ISOLATES USING NON-RADIOISOTOPIC SYBR GREEN I FLUORESCENCE ASSAY AND PFMDR COPY NUMBER ESTIMATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract C1 USAMRU Kenya, Walter Reed Project, kisumu, Kenya. Australian Army Malaria Inst, Enoggera, Australia. Walter Reed Army Inst Res, Silver Spring, MD USA. USAMRU Kenya, Water Reed Project, Nairobi, Kenya. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 SU S MA 983 BP 288 EP 289 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601607 ER PT J AU Ubalee, R Jin, XN Asher, C Carrol, D Jenwithisuk, R Sattabongkot, J Richardson, J Kozar, MP Melendez, V AF Ubalee, Ratawan Jin, Xiannu Asher, Constance Carrol, Dustin Jenwithisuk, Rachaneeporn Sattabongkot, Jetsumon Richardson, Jason Kozar, Michael P. Melendez, Victor TI METABOLISM OF CYP450 MARKERS OF ENZYMATIC ACTIVITY AND PRIMAQUINE BY THE INDUCED HC-04 IMMORTALIZED HEPATIC CELL LINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Ubalee, Ratawan; Jenwithisuk, Rachaneeporn; Sattabongkot, Jetsumon; Richardson, Jason] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand. [Jin, Xiannu; Asher, Constance; Carrol, Dustin; Kozar, Michael P.; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RI Kozar, Michael/A-9155-2011; Richardson, Jason/A-9441-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 980 BP 288 EP 288 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601345 ER PT J AU Sedegah, M McGrath, S Regis, D Chuang, I Ganeshan, H Abot, S Banania, G Manohar, N Doolan, D Limbach, K House, B Aguiarl, J Long, C Bruder, J King, C Patterson, N Tamminga, C Epstein, J Mendoza-Silveiras, J Williams, F Soisson, L Diggs, C Ockenhouse, C Richie, T AF Sedegah, Martha McGrath, Shannon Regis, David Chuang, Ilin Ganeshan, Harini Abot, Stephen Banania, Glena Manohar, Nalini Doolan, Denise Limbach, Keith House, Brent Aguiarl, Joao Long, Carole Bruder, Joseph King, Christopher Patterson, Noelle Tamminga, Cindy Epstein, Judith Mendoza-Silveiras, Jose Williams, Frank Soisson, Lorraine Diggs, Carter Ockenhouse, Christopher Richie, Thomas TI IMMUNOGENICITY OF TWO DOSES OF A MULTI-STAGE, MULTI-ANTIGEN ADENOVIRUS-VECTORED PLASMODIUM FALCIPARUM MALARIA VACCINE IN A PHASE 1 TRIAL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Sedegah, Martha; Regis, David; Chuang, Ilin; Ganeshan, Harini; Abot, Stephen; Banania, Glena; Manohar, Nalini; Doolan, Denise; Limbach, Keith; House, Brent; Aguiarl, Joao; Patterson, Noelle; Tamminga, Cindy; Epstein, Judith; Richie, Thomas] USN, Med Res Ctr, Silver Spring, MD USA. [McGrath, Shannon; Ockenhouse, Christopher] Walter Reed Army Inst Res, Silver Spring, MD USA. [Long, Carole] NIH, Bethesda, MD 20892 USA. [Bruder, Joseph; King, Christopher] GenVec, Gaithersburg, MD USA. [Williams, Frank] Natl Naval Med Ctr, Bethesda, MD USA. [Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Washington, DC 20523 USA. RI Doolan, Denise/F-1969-2015 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1034 BP 304 EP 304 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601398 ER PT J AU Thera, MA Doumbo, OK Coulibaly, D Laurens, MB Kone, AK Guindo, AB Diallo, DA Traore, K Diarra, I Niangaly, A Dolo, A Daou, M Sissoko, M Sagara, I Sissoko, MS Kouriba, B Lyke, KE Takala, SL Godeaux, O Soisson, L Lanar, DE Dutta, S House, B Heppner, DG Plowe, CV Baby, M Thonnard, J Leach, A Dubois, MC Cohen, J Ballou, WR Diggs, C Ware, LA Cummings, JF Stewart, VA AF Thera, Mahamadou A. Doumbo, Ogobara K. Coulibaly, Drissa Laurens, Matthew B. Kone, Abdoulaye K. Guindo, Ando B. Diallo, Dapa A. Traore, Karim Diarra, Issa Niangaly, Amadou Dolo, Amagana Daou, Modibo Sissoko, Mady Sagara, Issaka Sissoko, Mahamadou S. Kouriba, Bourema Lyke, Kirsten E. Takala, Shannon L. Godeaux, Olivier Soisson, Lorraine Lanar, David E. Dutta, Sheetij House, Brent Heppner, D. Gray Plowe, Christopher V. Baby, Mounirou Thonnard, Joelle Leach, Amanda Dubois, Marie-Claude Cohen, Joe Ballou, W. Ripley Diggs, Carter Ware, Lisa A. Cummings, James F. Stewart, V. Ann TI RANDOMIZED, CONTROLLED, DOSE ESCALATION PHASE 1 CLINICAL TRIAL TO EVALUATE THE SAFETY AND IMMUNOGENICITY OF WALTER REED ARMY INSTITUTE OF RESEARCH'S AMA-1 MALARIA VACCINE (FMP2.1) ADJUVANTED IN GSK BIOLOGICALS' AS02 VS. RABIES VACCINE IN 1-6 YEAR OLD CHILDREN IN BANDIAGARA, MALI SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Thera, Mahamadou A.; Doumbo, Ogobara K.; Coulibaly, Drissa; Kone, Abdoulaye K.; Guindo, Ando B.; Diallo, Dapa A.; Traore, Karim; Diarra, Issa; Niangaly, Amadou; Dolo, Amagana; Daou, Modibo; Sissoko, Mady; Sagara, Issaka; Sissoko, Mahamadou S.; Kouriba, Bourema; Baby, Mounirou] Univ Bamako, Fac Med, Bamako, Mali. [Laurens, Matthew B.; Lyke, Kirsten E.; Takala, Shannon L.; Plowe, Christopher V.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Godeaux, Olivier; Leach, Amanda; Dubois, Marie-Claude; Cohen, Joe; Ballou, W. Ripley] GlaxoSmithKline Biol, Rixensart, Belgium. [Soisson, Lorraine; Diggs, Carter] US Agcy Int Dev, Washington, DC 20523 USA. [Lanar, David E.; Dutta, Sheetij; House, Brent; Heppner, D. Gray; Ware, Lisa A.; Cummings, James F.; Stewart, V. Ann] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Lanar, David/B-3560-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1036 BP 304 EP 305 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601400 ER PT J AU Patterson, NB Ganeshan, H Abot, E Banania, J Lejano, JN Manohar, N Gowda, K Limbach, K McGrath, S Marshall, SA Ferrari, ME Bruder, JT King, CR Doolan, DL Richie, TL Sedegah, M AF Patterson, Noelle B. Ganeshan, Harini Abot, Esteban Banania, JoGlenna Lejano, Jennylynn N. Manohar, Nalini Gowda, Kalpana Limbach, Keith McGrath, Shannon Marshall, Stephanie A. Ferrari, Marilyn E. Bruder, Joseph T. King, C. Richter Doolan, Denise L. Richie, Thomas L. Sedegah, Martha TI A PLASMODIUM FALCIPARUM MULTI-ANTIGEN MULTI-STAGE PLASMID DNA PRIME/ADENOVECTOR BOOST VACCINE, NMRC-M3V-D/AD-PFCA, IS IMMUNOGENIC IN BALB/C MICE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Patterson, Noelle B.; Ganeshan, Harini; Abot, Esteban; Banania, JoGlenna; Lejano, Jennylynn N.; Manohar, Nalini; Gowda, Kalpana; Limbach, Keith; McGrath, Shannon; Marshall, Stephanie A.; Richie, Thomas L.; Sedegah, Martha] US Mil Malaria Vaccine Program, Naval Med Res Ctr, Silver Spring, MD USA. [Patterson, Noelle B.; Ganeshan, Harini; Abot, Esteban; Banania, JoGlenna; Lejano, Jennylynn N.; Manohar, Nalini; Gowda, Kalpana; Limbach, Keith; McGrath, Shannon; Marshall, Stephanie A.; Richie, Thomas L.; Sedegah, Martha] US Mil Malaria Vaccine Program, Walter Reed Army Inst Res, Silver Spring, MD USA. [Ferrari, Marilyn E.] Vical Inc, San Diego, CA USA. [Bruder, Joseph T.; King, C. Richter] GenVec Inc, Gaithersburg, MD USA. [Doolan, Denise L.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. RI Doolan, Denise/F-1969-2015 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1037 BP 305 EP 305 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601401 ER PT J AU Dutta, S Clayton, JW Spring, MD Chow, LH AF Dutta, Sheetij Clayton, Joshua W. Spring, Michele D. Chow, Lin H. TI RATIONAL DESIGN OF A PAN-REACTIVE APICAL MEMBRANE ANTIGEN-1 BASED MALARIA VACCINE USING SEROTYPES AND EPITOPE MAPS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Dutta, Sheetij; Clayton, Joshua W.; Spring, Michele D.; Chow, Lin H.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Spring, Michele/B-3564-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1040 BP 306 EP 306 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601404 ER PT J AU Husain, T Richie, TL Weiss, W AF Husain, Tupur Richie, Thomas L. Weiss, Walter TI ASSESSING PARASITE BURDEN IN PLASMODIUM KNOWLESI/RHESUS MONKEY SPOROZOITE CHALLENGE MODEL BY QUANTITATIVE REAL-TIME PCR AND HISTOLOGY SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Husain, Tupur; Richie, Thomas L.; Weiss, Walter] USN, Med Res Ctr, Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1046 BP 307 EP 308 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601410 ER PT J AU Tachibana, M Iriko, H Muratova, O Song, G Wu, Y Sattabongkot, J Takeo, S Otsuki, H Torii, M Tsuboi, T AF Tachibana, Mayumi Iriko, Hideyuki Muratova, Olga Song, Guanhong Wu, Yimin Sattabongkot, Jetsumon Takeo, Satoru Otsuki, Hitoshi Torii, Motomi Tsuboi, Takafumi TI IMMUNIZATION WITH RECOMBINANT PROTEINS OF A GAMETOCYTE PROTEIN PFS230 EXPRESSED USING WHEAT GERM CELL-FREE SYSTEM SUCCESSFULLY INDUCE TRANSMISSION-BLOCKING ANTIBODIES AGAINST PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Tachibana, Mayumi; Otsuki, Hitoshi; Torii, Motomi] Ehime Univ, Grad Sch Med, Dept Mol Parasitol, Toon, Ehime, Japan. [Iriko, Hideyuki] Tottori Univ, Fac Med, Dept Microbiol & Immunol, Tottori 680, Japan. [Muratova, Olga; Song, Guanhong; Wu, Yimin] NIAID, Malaria Vaccine Dev Branch, Rockville, MD USA. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Takeo, Satoru; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime, Japan. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1043 BP 307 EP 307 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601407 ER PT J AU Tucker, MS Peters, J Nau, M Wang, ZN Cheng, Q Vahey, M Lukas, S Azizan, A Kyle, DE AF Tucker, Matthew S. Peters, Jennifer Nau, Martin Wang, Zhinning Cheng, Qin Vahey, Maryanne Lukas, Susan Azizan, Azliyati Kyle, Dennis E. TI EXAMINATION OF THE MOLECULAR BASIS OF RESISTANCE TO ARTEMISININ DRUGS IN PLASMODIUM FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Tucker, Matthew S.; Lukas, Susan; Azizan, Azliyati; Kyle, Dennis E.] Univ S Florida, Tampa, FL USA. [Peters, Jennifer] Queensland Inst Med Res, Brisbane, Qld 4006, Australia. [Nau, Martin; Wang, Zhinning; Vahey, Maryanne] Walter Reed Army Inst Res, Rockville, MD USA. RI Azizan, Azliyati/A-6774-2009 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1122 BP 329 EP 329 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601485 ER PT J AU Saunders, D Li, QQ Misty, C Xie, L Zheng, Q Zhang, J Mendez, J Tally, J Magill, A Max, G Jiang, S Weina, P AF Saunders, David Li, Qiqui Misty, Carlson Xie, Lisa Zheng, Qiang Zhang, Jing Mendez, Juan Tally, John Magill, Alan Max, Grogl Jiang, Suping Weina, Peter TI ANTILEISHMANIAL ACTIVITY OF SELECTED FDA-APPROVED DRUGS IN A MURINE CUTANEOUS LEISHMANIASIS MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY DEC 07-11, 2008 CL New Orleans, LA SP Amer Soc Trop Med & Hyg C1 [Saunders, David; Li, Qiqui; Misty, Carlson; Xie, Lisa; Zheng, Qiang; Zhang, Jing; Mendez, Juan; Tally, John; Magill, Alan; Max, Grogl; Jiang, Suping; Weina, Peter] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 MA 1207 BP 355 EP 355 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZT UT WOS:000261644601570 ER PT J AU Hartzell, JD Aronson, NE Weina, PJ Howard, RS Yadava, A Wortmann, GW AF Hartzell, Joshua D. Aronson, Naomi E. Weina, Peter J. Howard, Robin S. Yadava, Anjali Wortmann, Glenn W. TI Positive rK39 Serologic Assay Results in US Servicemen with Cutaneous Leishmaniasis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID AMERICAN VISCERAL LEISHMANIASIS; DIRECT AGGLUTINATION-TEST; STRIP-TEST; IDENTIFICATION; DIAGNOSIS; DIPSTICK; ANTIBODY; CHAGASI; ANTIGEN AB The rK39 test is a serologic assay for the rapid diagnosis of visceral leishmaniasis (VL). Serum from a North American cohort of 59 otherwise asymptomatic soldiers with cutaneous leishmaniasis (CL) was tested with the rK39 dipstick and ELISA assays, and 10.2%, and 28.8% had positive results, respectively. CL is associated with a reactive rK39 assay result in sonic patients without clinical evidence of VL. C1 Walter Reed Army Med Ctr, Div Infect Dis, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Div Infect Dis, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Hartzell, JD (reprint author), Walter Reed Army Med Ctr, Div Infect Dis, BLD 2,Ward 63,0900 Georgia Ave NW, Washington, DC 20307 USA. EM joshua.hartzell@amedd.army.mil RI Weina, Peter/A-2120-2011 FU Infectious Disease Clinical Research Program and Military Infectious Disease Research Program FX This study was supported by the Infectious Disease Clinical Research Program and Military Infectious Disease Research Program. NR 13 TC 9 Z9 9 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 BP 843 EP 846 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZR UT WOS:000261644400007 PM 19052290 ER PT J AU Hillesland, H Read, A Subhadra, B Hurwitz, I McKelvey, R Ghosh, K Das, P Durvasula, R AF Hillesland, Heidi Read, Amber Subhadra, Bobban Hurwitz, Ivy McKelvey, Robin Ghosh, Kashinath Das, Pradeep Durvasula, Ravi TI Identification of Aerobic Gut Bacteria from the Kala Azar Vector, Phlebotomus argentipes: A Platform for Potential Paratransgenic Manipulation of Sand Flies SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID BREVIBACTERIUM-CASEI; GORDONIA-TERRAE; STAPHYLOCOCCUS-COHNII; HOSPITALIZED-PATIENTS; LEISHMANIA-DONOVANI; BACILLUS-SUBTILIS; INFECTION; DISEASE; CHOLANGITIS; SEPTICEMIA AB Visceral leishmaniasis is an understudied parasitic disease responsible for significant global morbidity and mortality. We are presently investigating a method of disease prevention termed paratransgenesis. In this approach, symbiotic or commensal bacteria are transformed to produce anti-Leishmania molecules. The transformed bacteria are delivered back to sand flies to inactivate the parasite within the vector itself. In this study, we identified 28 distinct gut microorganisms from Phlebotomus argentipes trapped from four visceral leishmaniasis-endemic sites in India. A significant percent of Staphylococcus spp., environmental bacteria, and Enterobacteriaceae were identified. Two non-pathogenic organisms. Bacillus megaterium and Brevibacterium linens, were also isolated. Both organisms are also Used extensively in industry. Our results indicate that B. megaterium and B. linens are possible candidates for use in a model of paratransgenesis to prevent transmission of Leishmania. C1 Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA. Rajendra Mem Res Inst Med Sci, Patna, Bihar, India. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Durvasula, R (reprint author), Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA. EM ravi.durvasula@va.gov NR 45 TC 30 Z9 31 U1 2 U2 10 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2008 VL 79 IS 6 BP 881 EP 886 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 382ZR UT WOS:000261644400014 PM 19052297 ER PT J AU Szpisjak, DF Javernick, EN Kyle, RR Austin, PN AF Szpisjak, Dale F. Javernick, Elizabeth N. Kyle, Richard R. Austin, Paul N. TI Oxygen Consumption of a Pneumatically Controlled Ventilator in a Field Anesthesia Machine SO ANESTHESIA AND ANALGESIA LA English DT Article ID MECHANICAL VENTILATION AB BACKGROUND: Field anesthesia machines (FAM) have been developed for remote locations where reliable supplies of compressed medical gases or electricity may be absent. In place of electricity, pneumatically controlled ventilators use compressed gas to power timing circuitry and actuate valves. We sought to determine the total O(2) consumption and ventilator gas Consumption (drive gas [DG] plus pneumatic control [PC] gas) of a FAM's Pneumatically controlled ventilator in mechanical models of high (HC) and low (LC) total thoracic compliance. METHODS: The amount of total O(2) consumed by the Magellan-2200 (Oceanic Medical Products, Atchison, KS) FAM with pneumatically controlled ventilator was calculated using the ideal gas law and the measured mass of O(2) consumed from E cylinders. DG to the bellows canister assembly was measured with the Wright Respirometer Mk 8 (Ferraris Respiratory Europe, Hertford, UK). PC gas consumption was calculated by subtracting DG and fresh gas flow (FGF) from the total O(2) Consumed from the E cylinder. The delivered tidal volume (V(T)) was measured with a pneumotach (Hans Rudolph, KS City, MO). Three different V, were tested (500, 750, and 1.000 mL) with two lung models (HC and LC) using the Vent Aid Training Test Lung (MI Instruments, Grand Rapids, MI). Respiratory variables included all I:E of 1:2, FGF of 1 L/min, and respiratory rate of 10 breaths/min. RESULTS: Total O(2) consumption was directly proportional to V(T) and inversely proportional to compliance. The smallest total O(2) consumption rate (including FGF) was 9.3 +/- 0.4 L/min in the HC-500 model and the largest was 15.9 +/- 0.5 L/min in the LC-1000 model (P < 0.001.). The mean PC circuitry consumption was 3.9 +/- 0.24 L/min or 390 mL +/- 24 mL/breath. CONCLUSIONS: To prepare for loss of central DG supply, patient safety will be improved by estimating cylinder duration for low total thoracic compliance. Using data from the smaller compliance and greatest V(T) model (LC-1000), a full O(2) E cylinder Would be depleted in <42 min, whereas a full H cylinder would last approximately 433 min. C1 [Szpisjak, Dale F.] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. [Javernick, Elizabeth N.] Walter Reed Army Med Ctr, Dept Anesthesiol, Washington, DC 20307 USA. [Kyle, Richard R.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Austin, Paul N.] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. RP Szpisjak, DF (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM dszpisjak@usuhs.mil FU Defense Advanced Research Projects Agency, Arlington, VA FX Supported by a grant from the Defense Advanced Research Projects Agency, Arlington, VA. NR 6 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD DEC PY 2008 VL 107 IS 6 BP 1907 EP 1911 DI 10.1213/ane.0b013e31818a04da PG 5 WC Anesthesiology SC Anesthesiology GA 376PZ UT WOS:000261196800024 PM 19020137 ER PT J AU Stojadinovic, A Elster, EA Anam, K Tadaki, D Amare, M Zins, S Davis, TA AF Stojadinovic, Alexander Elster, Eric A. Anam, Khairul Tadaki, Douglas Amare, Mihret Zins, Stephen Davis, Thomas A. TI Angiogenic response to extracorporeal shock wave treatment in murine skin isografts SO ANGIOGENESIS LA English DT Article DE Angiogenesis; Extracorporeal shock wave therapy; Skin graft; Wound healing ID ENDOTHELIAL PROGENITOR CELLS; VACUUM-ASSISTED CLOSURE; GROWTH-FACTOR-BETA; FLAP SURVIVAL; GENE-THERAPY; BONE-MARROW; ELECTRICAL-STIMULATION; ISCHEMIC NECROSIS; MODEL; ULTRASOUND AB Skin grafts are commonly utilized and proven effective methods of open wound coverage. Revascularization through neoangiogenesis is a pivotal mechanism for skin graft integration and durability. Extracorporeal shock-wave treatment (ESWT) has been demonstrated to accelerate wound repair; however, its mechanism-of-action is unclear. We investigated the role of ESWT in early revascularization of full-thickness skin isografts in a murine model. Cohorts of mice were euthanized and skin grafts were harvested 6 h, 2, 4, and 7 days post grafting +/- A ESWT. Various aspects of graft neovascularization were measured including gross morphology, quantitative microscopy (vessel number, density), immunohistochemistry (CD31), cDNA SuperArrays for 84 angiogenesis-specific genes, and custom-designed 'Wound Repair' TaqMan(A (R)) Low Density Array (TLDA) cards to assess expression of 188 wound repair genes. We demonstrate that a single administration of ESWT immediately following skin grafting significantly enhances recipient graft revascularization (increased vessel number, size, and density). An augmented early pro-angiogenic and suppressed delayed pro-inflammatory response to ESWT was accompanied by significantly increased expression of both skin graft CD31 and angiogenesis pathway-specific genes, including ELR-CXC chemokines (CXCL1, CXCL2, CXCL5), CC chemokines (CCL2, CCL3, CCL4), cytokines (IL-1 beta, IL-6, G-CSF, VEGF-A), matrix metalloproteinases (MMP3, MMP9, MMP13), hypoxia-inducible factors (HIF-1 alpha), and vascular remodeling kinase (Mst1), as early as 6 h and up to 7 days post grafting and treatment. These findings suggest that early pro-angiogenic and anti-inflammatory effects of ESWT promote tissue revascularization and wound healing by augmenting angiogenesis and dampening inflammation. C1 [Elster, Eric A.; Anam, Khairul; Tadaki, Douglas; Amare, Mihret; Zins, Stephen; Davis, Thomas A.] USN, Regenerat Med Dept, Med Res Ctr, Silver Spring, MD 20910 USA. [Elster, Eric A.] Natl Naval Med Ctr, Combat Wound Initiat Program, Dept Surg, Bethesda, MD USA. [Stojadinovic, Alexander; Davis, Thomas A.] Walter Reed Army Med Ctr, Dept Surg, Combat Wound Initiat Program, Washington, DC 20307 USA. [Stojadinovic, Alexander; Elster, Eric A.; Tadaki, Douglas] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Davis, TA (reprint author), USN, Regenerat Med Dept, Med Res Ctr, Room 2A10,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM thomas.davis1@med.navy.mil FU ONR [602236N.42237, W160.A0806]; Henry M. Jackson Foundation FX This work was supported by ONR work unit 602236N.42237. W160.A0806 and by the Combat Wound Initiative Program, a Congressionally funded program of the Henry M. Jackson Foundation for the Advancement of Military Medicine. NR 54 TC 54 Z9 55 U1 2 U2 4 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0969-6970 J9 ANGIOGENESIS JI Angiogenesis PD DEC PY 2008 VL 11 IS 4 BP 369 EP 380 DI 10.1007/s10456-008-9120-6 PG 12 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 392NP UT WOS:000262309700006 PM 18998221 ER PT J AU Abadie, JM Koelsch, AA AF Abadie, Jude M. Koelsch, Angela A. TI Performance of the Roche second generation hemoglobin A1c immunoassay in the presence of Hb-S or Hb-C traits SO ANNALS OF CLINICAL AND LABORATORY SCIENCE LA English DT Article DE hemoglobin A1c; hemoglobinopathies; HbS; HbC; diabetes mellitus; HbA1c immunoassay ID GLYCOHEMOGLOBIN METHODS; HBA(1C); VARIANTS; DERIVATIVES; ANALYZER; A(1C); HPLC AB Blood HbA1c determination is a powerful tool for the evaluation and management of patients with diabetes mellitus. Many HbA1c analytical methods demonstrate bias in samples from patients with hemoglobinopathies. This study evaluated the analytical performance of Roche Diagnostics' 1st and 2nd generation HbA1c assays in patients with or without hemoglobinopathies whose HbA1c levels were elevated or normal, respectively. Boronate-affinity high performance liquid chromatography (HPLC) served as the reference method. Whole blood samples were collected from 80 patients with HbS or HbC whose group mean HbA1c value was elevated and also from 80 patients without hemoglobinopathy whose HbA1c values were in the well-controlled range. Each sample was assayed for HbA1c by the Primus boronate-affinity HPLC technique and by Roche's 1st and 2nd generation immunoassays using a Cobas Integra 800 analytical system. Results by the HPLC technique were compared with the results of both Roche assays by linear regression and Bland-Altman analysis. The 1st and 2nd generation assays yielded regression lines and correlation values vs HPLC assay of y = 1.43x - 1.59; R-2 = 0.83, and y = 0.94x + 0.10; R-2 = 0.92, respectively, in the 80 patients with hemoglobinopathies. The mean difference and the +/- 2SD range were greater in the 1st than in the 2nd generation assay (2.68, +/- 2.07 vs -0-54, +/- 0.86, respectively). The 2nd generation assay also showed better performance than the 1st generation assay in samples from the 80 patients without hemoglobinopathy. In conclusion, this study validates the accuracy of Roche's 2nd generation assay, which is substantially improved over Roche's 1st generation HbA1c assay. C1 [Abadie, Jude M.; Koelsch, Angela A.] Walter Reed Army Med Ctr, Core Lab, Dept Pathol, Washington, DC 20307 USA. RP Abadie, JM (reprint author), Walter Reed Army Med Ctr, Core Lab, Dept Pathol, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM jude.abadie@amedd.army.mil NR 21 TC 16 Z9 18 U1 1 U2 2 PU ASSOC CLINICAL SCIENTISTS PI MIDDLEBURY PA PO BOX 1287, MIDDLEBURY, VT 05753 USA SN 0091-7370 J9 ANN CLIN LAB SCI JI Ann. Clin. Lab. Sci. PD WIN PY 2008 VL 38 IS 1 BP 31 EP 36 PG 6 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 267ER UT WOS:000253492800006 PM 18316779 ER PT J AU Moran, ML Greenfield, RJ Wilson, DK AF Moran, Mark L. Greenfield, Roy J. Wilson, D. Keith TI Acoustic array tracking performance under moderately complex environmental conditions (vol 68, pg 1241, 2007) SO APPLIED ACOUSTICS LA English DT Correction C1 [Moran, Mark L.; Greenfield, Roy J.; Wilson, D. Keith] USA, Corps Engineers, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Moran, ML (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM mark.l.moran@erdc.usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X J9 APPL ACOUST JI Appl. Acoust. PD DEC PY 2008 VL 69 IS 12 BP 1368 EP 1368 DI 10.1016/j.apacoust.2007.11.003 PG 1 WC Acoustics SC Acoustics GA 369QI UT WOS:000260708600025 ER PT J AU Vanderploeg, RD Schwab, K Walker, WC Fraser, JA Sigford, BJ Date, ES Scott, SG Curtiss, G Salazar, AM Warden, DL AF Vanderploeg, Rodney D. Schwab, Karen Walker, William C. Fraser, Jamie A. Sigford, Barbara J. Date, Elaine S. Scott, Steven G. Curtiss, Glenn Salazar, Andres M. Warden, Deborah L. CA Defense Vet Brain Injury Ctr Study TI Rehabilitation of Traumatic Brain Injury in Active Duty Military Personnel and Veterans: Defense and Veterans Brain Injury Center Randomized Controlled Trial of Two Rehabilitation Approaches SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Brain injuries; Cognition; Rehabilitation; Treatment outcome ID COGNITIVE REHABILITATION; HEAD-INJURY; UNITED-STATES; RATING-SCALE; INTERVENTION; DISABILITY; INTENSITY; CLINICIAN; EFFICACY; MODERATE AB Objectives: To determine the relative efficacy of 2 different acute traumatic brain injury (TBI) rehabilitation approaches: cognitive didactic versus functional-experiential and secondarily to determine relative efficacy for different patient subpopulations. Design: Randomized, controlled, intent-to-treat trial comparing 2 alternative TBI treatment approaches. Setting: Four Veterans Administration acute inpatient TBI rehabilitation programs. Participants: Adult veterans or active duty military service members (N=360) with moderate to severe TBI. Interventions: One and a half to 2.5 hours of protoco specific cognitive-didactic versus functional-experiential rehabilitation therapy integrated into interdisciplinary acute Commission for Accreditation of Rehabilitation Facilities-accredited inpatient TBI rehabilitation programs with another 2 to 2.5 hours daily of occupational and physical therapy. Duration of protocol treatment varied from 20 to 60 days depending on the clinical needs and progress of each participant. Main Outcome Measures: The 2 primary outcome measures were functional independence in living and return to work and/or school assessed by independent evaluators at 1-year follow-up. Secondary outcome measures consisted of the FIM, Disability Rating Scale score, and items from the Present State Exam, Apathy Evaluation Scale, and Neurobehavioral Rating Scale. Results: The cognitive-didactic and functional-experiential treatments did not result in overall group differences in the broad 1-year primary outcomes. However, analysis of secondary outcomes found differentially better immediate posttreatment cognitive function (mean +/- SD cognitive FIM) in participants randomized to cognitive-didactic treatment (27.3 +/- 6.2) than to functional treatment (25.6 +/- 6.0, t(332)=2.56, P=.01). Exploratory subgroup analyses found that younger participants in the cognitive arm had a higher rate of returning to work or school than younger patients in the functional arm, whereas participants older than 30 years and those with more years of education in the functional arm had higher rates of independent living status at 1 year posttreatment than similar patients in the cognitive arm. Conclusions: Results from this large multicenter randomized controlled trial comparing cognitive-didactic and functional-experiential approaches to brain injury rehabilitation indicated improved but similar long-term global functional outcome. Participants in the cognitive treatment arm achieved better short-term functional cognitive performance than patients in the functional treatment arm. The current increase in war-related brain injuries provides added urgency for rigorous study of rehabilitation treatments. (http://ClinicalTrials.gov ID# NCT00540020.) C1 [Vanderploeg, Rodney D.; Curtiss, Glenn] James A Haley Vet Affairs Med Ctr, Dept Mental Hlth & Behav Sci, Tampa, FL 33612 USA. [Vanderploeg, Rodney D.; Curtiss, Glenn] James A Haley Vet Affairs Med Ctr, Def & Vet Brain Injury Ctr, Tampa, FL 33612 USA. [Vanderploeg, Rodney D.; Curtiss, Glenn] Univ S Florida, Dept Psychiat & Behav Med, Tampa, FL USA. [Vanderploeg, Rodney D.] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. [Schwab, Karen; Fraser, Jamie A.; Warden, Deborah L.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. [Schwab, Karen; Warden, Deborah L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Walker, William C.] Hunter H McGuire Vet Affairs Med Ctr, Def & Vet Brain Injury Ctr, Richmond, VA USA. [Walker, William C.] Virginia Commonwealth Univ, Sch Med, Dept Phys Med & Rehabil, Richmond, VA USA. [Sigford, Barbara J.] Minneapolis Vet Affairs Med Ctr, Minneapolis, MN USA. [Date, Elaine S.] Vet Affairs Palo Alto Hlth Care Syst, Comprehens Rehabil Ctr, Palo Alto, CA USA. [Date, Elaine S.] Stanford Univ, Sch Med, Dept Orthopaed Surg, Stanford, CA 94305 USA. [Scott, Steven G.] James A Haley Vet Affairs Med Ctr, Polytrauma Rehabil Ctr, Phys Med & Rehabil Serv, Tampa, FL 33612 USA. [Scott, Steven G.] Univ S Florida, Coll Med, Dept Internal Med, Phys Med & Rehabil Sect, Tampa, FL 33612 USA. [Salazar, Andres M.] Oncovir Inc, Washington, DC USA. RP Vanderploeg, RD (reprint author), James A Haley Vet Affairs Med Ctr, Dept Mental Hlth & Behav Sci, 116B,13000 N Bruce B Downs Blvd, Tampa, FL 33612 USA. EM Rodney.Vanderploeg@va.gov RI Walker, William/N-3162-2014 NR 49 TC 61 Z9 61 U1 5 U2 23 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD DEC PY 2008 VL 89 IS 12 BP 2227 EP 2238 DI 10.1016/j.apmr.2008.06.015 PG 12 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 385GY UT WOS:000261803900001 PM 19061734 ER PT J AU Chinnawirotpisan, P Mammen, MP Nisalak, A Thaisomboonsuk, B Narupiti, S Thirawuth, V Putnak, R Zhang, CL AF Chinnawirotpisan, P. Mammen, M. P., Jr. Nisalak, A. Thaisomboonsuk, B. Narupiti, S. Thirawuth, V. Putnak, R. Zhang, Chunlin TI Detection of concurrent infection with multiple dengue virus serotypes in Thai children by ELISA and nested RT-PCR assay SO ARCHIVES OF VIROLOGY LA English DT Article ID POLYMERASE CHAIN-REACTION; CO-CIRCULATION; MOSQUITO; IDENTIFICATION; BANGKOK; DENV-3; TYPE-2; FEVER AB The prevailing global spread of four dengue virus (DENV) serotypes and the resultant co-circulation of multiple serotypes in the same region have invariably led to conditions supporting the periodic occurrence of simultaneous infection of individuals with more than one DENV serotype. This raises the issue of how best to detect concurrent multiple infections. We report here the use of a nested reverse transcription-polymerase chain reaction (RT-PCR) assay, which detected concurrent infection with three DENV serotypes (DENV-1/DENV-2/DENV-3) and two serotypes (DENV-1/DENV-2 and DENV-2/DENV-4), respectively, in three serum specimens from Thai children hospitalized during the dengue epidemic of 2000-2001. In contrast, an enzyme-linked immunosorbent assay used previously for virus serotype identification failed to detect multiple DENV serotypes in these specimens. Serotype identification by RT-PCR was confirmed by sequence analysis of each amplified PCR product. Phylogenetic analyses performed on PCR-amplified DNA fragments further supported the occurrence of concurrent infections with multiple DENV serotypes in these children. Although the sample set was small, our data suggest that nested RT-PCR is an effective method for the detection of concurrent DENV infections. C1 [Putnak, R.; Zhang, Chunlin] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Chinnawirotpisan, P.; Mammen, M. P., Jr.; Nisalak, A.; Thaisomboonsuk, B.; Narupiti, S.; Thirawuth, V.; Zhang, Chunlin] USA, Med Component Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. RP Zhang, CL (reprint author), Walter Reed Army Inst Res, Div Viral Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM chunlin.zhang@amedd.army.mil FU US Military Infectious Disease Research Program, Fort Detrick, Maryland, USA FX We thank the doctors and nurses of QSNICH/AFRIMS for specimen collection and clinical grading. We gratefully acknowledge Dr. Yuxin Tang, Tao Li and Richard Zhao for assistance with the manuscript preparation. This research was supported by the US Military Infectious Disease Research Program, Fort Detrick, Maryland, USA. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the official views of the US Army or the Department of Defense. NR 28 TC 15 Z9 17 U1 0 U2 3 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0304-8608 J9 ARCH VIROL JI Arch. Virol. PD DEC PY 2008 VL 153 IS 12 BP 2225 EP 2232 DI 10.1007/s00705-008-0249-9 PG 8 WC Virology SC Virology GA 391KJ UT WOS:000262231900006 PM 19011729 ER PT J AU Vogt, DS Proctor, SP King, DW King, LA Vasterling, JJ AF Vogt, Dawne S. Proctor, Susan P. King, Daniel W. King, Lynda A. Vasterling, Jennifer J. TI Validation of Scales From the Deployment Risk and Resilience Inventory in a Sample of Operation Iraqi Freedom Veterans SO ASSESSMENT LA English DT Article DE war-zone exposure; military deployments; veterans; Operation Iraqi Freedom; psychometric evaluation ID POSTTRAUMATIC-STRESS-DISORDER; MALE VIETNAM VETERANS; MENTAL-HEALTH PROBLEMS; WAR-ZONE STRESSORS; LIFE-EVENTS; PSYCHOLOGICAL-ASSESSMENT; MILITARY PERSONNEL; CONSTRUCT-VALIDITY; MEDICAL OUTCOMES; NATIONAL SAMPLE AB The Deployment Risk and Resilience Inventory (DRRI) is a suite of scales that can be used to assess deployment-related factors implicated in the health and well-being of military veterans. Although initial evidence for the reliability and validity of DRRI scales based on Gulf War veteran samples is encouraging, evidence with respect to a more contemporary cohort of Operation Iraqi Freedom (OIF) veterans is not available. Therefore, the primary goal of the present study was to validate scales from the DRRI in a large sample of OIF army personnel diversified in occupational and demographic characteristics. In general, results supported the use of these DRRI scales in this population. Internal consistency reliability estimates were quite strong. Additionally, support was obtained for criterion-related validity, as demonstrated by associations with mental and physical health measures, and discriminative validity, as demonstrated by differences between key military subgroups. C1 [Vogt, Dawne S.] Boston Univ, Natl Ctr PTSD, Womens Hlth Sci Div, VA Boston Healthcare Syst,Dept Psychiat,Sch Med, Boston, MA 02215 USA. [King, Lynda A.] Boston Univ, Natl Ctr PTSD, Womens Hlth Sci Div, VA Boston Healthcare Syst,Dept Psychol, Boston, MA 02215 USA. [King, Daniel W.] Boston Univ, Natl Ctr PTSD, VA Boston Healthcare Syst, Behav Sci Div,Dept Psychol, Boston, MA 02215 USA. [Vasterling, Jennifer J.] Boston Univ, Natl Ctr PTSD, VA Boston Healthcare Syst, Behav Sci Div,Dept Psychiat,Sch Med,Psychol Serv, Boston, MA 02215 USA. [Proctor, Susan P.] Boston Univ, VA Boston Healthcare Syst, Dept Environm Hlth,Sch Publ Hlth,Res Serv, USA,Res Inst Environm Med,Mil Performance Div, Boston, MA 02215 USA. RP Vogt, DS (reprint author), VA Boston Healthcare Syst 116B5, Womens Hlth Sci Div, 150 S Huntington Ave, Boston, MA 02130 USA. EM dawne.vogt@va.gov NR 67 TC 34 Z9 34 U1 3 U2 12 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1073-1911 J9 ASSESSMENT JI Assessment PD DEC PY 2008 VL 15 IS 4 BP 381 EP 403 DI 10.1177/1073191108316030 PG 13 WC Psychology, Clinical SC Psychology GA 373TN UT WOS:000260996500001 ER PT J AU Yeh, IC Olson, MA Lee, MS Wallqvist, A AF Yeh, In-Chul Olson, Mark A. Lee, Michael S. Wallqvist, Anders TI Free-Energy Profiles of Membrane Insertion of the M2 Transmembrane Peptide from Influenza A Virus SO BIOPHYSICAL JOURNAL LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; HISTOGRAM ANALYSIS METHOD; COMPUTER-SIMULATIONS; REPLICA-EXCHANGE; LIPID-BILAYERS; PROTON CHANNELS; SIDE-CHAINS; PROTEINS; MODEL; RECOGNITION AB The insertion of the M2 transmembrane peptide from influenza A virus into a membrane has been studied with molecular-dynamics simulations. This system is modeled by an atomically detailed peptide interacting with a continuum representation of a membrane bilayer in aqueous solution. We performed replica-exchange molecular-dynamics simulations with umbrella-sampling techniques to characterize the probability distribution and conformation preference of the peptide in the solution, at the membrane interface, and in the membrane. The minimum in the calculated free-energy surface of peptide insertion corresponds to a fully inserted, helical peptide spanning the membrane. The free-energy profile also shows that there is a significant barrier for the peptide to enter into this minimum in a nonhelical conformation. The sequence of the peptide is such that hydrophilic amino acid residues at the ends of the otherwise primarily hydrophobic peptide create a trapped, U-shaped conformation with the hydrophilic residues associated with the aqueous phase and the hydrophobic residues embedded in the membrane. Analysis of the free energy shows that the barrier to insertion is largely enthalpic in nature, whereas the membrane-spanning global minimum is favored by entropy. C1 [Yeh, In-Chul; Lee, Michael S.; Wallqvist, Anders] USA, Biotechnol HPC Software Applicat Inst, Med Res & Mat Command, Telemed & Adv Technol Res Ctr,ATTN MCMR TT, Ft Detrick, MD 21702 USA. [Olson, Mark A.; Lee, Michael S.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. [Lee, Michael S.] USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD USA. RP Yeh, IC (reprint author), USA, Biotechnol HPC Software Applicat Inst, Med Res & Mat Command, Telemed & Adv Technol Res Ctr,ATTN MCMR TT, Bldg 363 Miller Dr, Ft Detrick, MD 21702 USA. EM icy@bioanalysis.org OI wallqvist, anders/0000-0002-9775-7469 NR 52 TC 9 Z9 9 U1 0 U2 10 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 EI 1542-0086 J9 BIOPHYS J JI Biophys. J. PD DEC 1 PY 2008 VL 95 IS 11 BP 5021 EP 5029 DI 10.1529/biophysj.108.133579 PG 9 WC Biophysics SC Biophysics GA 373UR UT WOS:000260999500004 PM 18676651 ER PT J AU Casadevall, A Ehrlich, SA Franz, DR Imperiale, MJ Keim, PS AF Casadevall, Arturo Ehrlich, Susan A. Franz, David R. Imperiale, Michael J. Keim, Paul S. TI BIODEFENSE RESEARCH: A WIN-WIN CHALLENGE SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Editorial Material C1 [Casadevall, Arturo] Yeshiva Univ, Albert Einstein Coll Med, Div Infect Dis, Bronx, NY USA. [Ehrlich, Susan A.] Arizona Court Appeals, Phoenix, AZ USA. [Franz, David R.] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Imperiale, Michael J.] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA. [Keim, Paul S.] No Arizona Univ, Dept Biol, Flagstaff, AZ 86011 USA. [Keim, Paul S.] Translat Genom Res Inst, Pathogen Genom Div, Flagstaff, AZ USA. RP Casadevall, A (reprint author), Yeshiva Univ, Albert Einstein Coll Med, Div Infect Dis, Bronx, NY USA. RI Keim, Paul/A-2269-2010 FU NIAID NIH HHS [U54 AI057158] NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD DEC PY 2008 VL 6 IS 4 BP 291 EP 292 DI 10.1089/bsp.2008.1114 PG 2 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 389YB UT WOS:000262130400005 PM 19090664 ER PT J AU Parnell, GS Borio, LL Brown, GG Banks, D Wilson, AG AF Parnell, Gregory S. Borio, Luciana L. Brown, Gerald G. Banks, David Wilson, Alyson G. TI SCIENTISTS URGE DHS TO IMPROVE BIOTERRORISM RISK ASSESSMENT SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article AB In 2006, the Department of Homeland Security (DHS) completed its first Bioterrorism Risk Assessment (BTRA), intended to be the foundation for DHS's subsequent biennial risk assessments mandated by Homeland Security Presidential Directive 10 (HSPD-10). At the request of DHS, the National Research Council established the Committee on Methodological Improvements to the Department of Homeland Security's Biological Agent Risk Analysis to provide an independent, scientific peer review of the BTRA. The Committee found a number of shortcomings in the BTRA, including a failure to consider terrorists as intelligent adversaries in their models, unnecessary complexity in threat and consequence modeling and simulations, and a lack of focus on risk management. The Committee unanimously concluded that an improved BTRA is needed to provide a more credible foundation for risk-informed decision making. C1 [Parnell, Gregory S.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Borio, Luciana L.] Univ Pittsburgh, Med Ctr, Ctr Biosecur, Baltimore, MD USA. [Brown, Gerald G.] USN, Postgrad Sch, Dept Operat Res, Monterey, CA USA. [Banks, David] Duke Univ, Dept Stat & Decis Sci, Durham, NC USA. [Wilson, Alyson G.] Iowa State Univ, Dept Stat, Ames, IA USA. RP Parnell, GS (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM gregory.parnell@usma.edu OI Wilson, Alyson/0000-0003-1461-6212 NR 7 TC 7 Z9 7 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD DEC PY 2008 VL 6 IS 4 BP 353 EP 356 DI 10.1089/bsp.2008.0930 PG 4 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 389YB UT WOS:000262130400012 PM 18976117 ER PT J AU Wolf, SE AF Wolf, Steven E. TI The year in burns 2007 SO BURNS LA English DT Review DE Burn research articles; Topics of clinical burn care ID PARTIAL-THICKNESS BURNS; ACUTE LUNG INJURY; INHALATION INJURY; RISK-FACTORS; DONOR-SITE; RANDOMIZED-TRIAL; HEALING-PROCESS; THERMAL-INJURY; BASE DEFICIT; YOUNG-ADULTS AB In the year 2007, approximately 1000 original burn research articles were published in scientific journals using the English language. This article reviews approximately 90 of these which were deemed by the author to be the most important in terms of clinical burn care. Relevant topics include epidemiology, wound characterisation, critical care physiology, inhalation injury, infection, metabolism and nutrition, psychological considerations, pain management, rehabilitation, and burn reconstruction. Each selected article is mentioned briefly with editorial comment. Published by Elsevier Ltd and ISBI C1 [Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA. [Wolf, Steven E.] USA, Inst Surg Res, San Antonio, TX 78229 USA. RP Wolf, SE (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl, San Antonio, TX 78229 USA. EM wolfs@uthscsa.edu OI Wolf, Steven/0000-0003-2972-3440 NR 88 TC 7 Z9 8 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD DEC PY 2008 VL 34 IS 8 BP 1059 EP 1071 DI 10.1016/j.burns.2008.05.029 PG 13 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 380IP UT WOS:000261459700001 PM 18786767 ER PT J AU Murray, CK Loo, FL Hospenthal, DR Cancio, LC Jones, JA Kim, SH Holcomb, JB Wade, CE Wolf, SE AF Murray, Clinton K. Loo, Florence L. Hospenthal, Duane R. Cancio, Leopoldo C. Jones, John A. Kim, Seung H. Holcomb, John B. Wade, Charles E. Wolf, Steven E. TI Incidence of systemic fungal infection and related mortality following severe burns SO BURNS LA English DT Article DE Fungus; Mortality; Burn; Attributable mortality ID SURGICAL PATIENTS; WOUND-INFECTION; COLONIZATION AB Advancements in burn care therapy have extended survival of seriously burned patients, exposing burn patients to increased risk of infectious complications, notably fungal infections. We performed a 12-year review of autopsied patients with severe bums for the presence of fungal infection at the US Army Institute of Surgical Research Burn Center between February 1991 and November 2003. The primary goal was to identify the relationship between fungal element noted in autopsy and mortality, and to determine contributing factors that increase a patient's susceptibility to fungal infection. A total of 228 deaths (6.1%) resulted from the 3751 admissions of which 97 underwent autopsy. Fungal elements were identified on histopathology in 44% (43 of 97) of autopsied patients with an attributable mortality of 33% (14 of 43). Aspergillus and Candida were the most frequently recovered fungi, but Aspergillus was recovered in 13 of the 14 cases with fungus identified as an attributable cause of death. The most common sites of infections with attributable mortality were wounds (86%) and the pulmonary system (14%). Total body surface area (TBSA) burn and length of stay (survival after burn) were identified as contributing factors for the incidence of fungal element in autopsy on ROC curve analysis. More severely injured patients with greater %TBSA burn injury and full-thickness burns require a longer recovery period resulting in a longer hospital stay. The propensity for fungal infection increases the longer the wound is present. Therefore, the development of products to close the wound more rapidly, improvement in topical antifungal therapy with mold activity for treating wounds, and implementation of appropriate systemic antifungal therapy may improve outcome for severely injured burn victims susceptible to fungal infections. Published by Elsevier Ltd and ISBI C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Loo, Florence L.; Cancio, Leopoldo C.; Jones, John A.; Kim, Seung H.; Holcomb, John B.; Wade, Charles E.; Wolf, Steven E.] USA, Inst Surg Res, Washington, DC USA. [Murray, Clinton K.; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 10 TC 47 Z9 48 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD DEC PY 2008 VL 34 IS 8 BP 1108 EP 1112 DI 10.1016/j.burns.2008.04.007 PG 5 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 380IP UT WOS:000261459700007 PM 18691821 ER PT J AU Keefer, ML Wertheimer, RH Evans, AF Boggs, CT Peery, CA AF Keefer, Matthew L. Wertheimer, Robert H. Evans, Allen F. Boggs, Charles T. Peery, Christopher A. TI Iteroparity in Columbia River summer-run steelhead (Oncorhynchus mykiss): implications for conservation SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID SALMON SALMO-SALAR; LIFE-HISTORY CHARACTERISTICS; JUVENILE CHINOOK SALMON; ATLANTIC SALMON; SALVELINUS-ALPINUS; DELAYED MORTALITY; HYDROELECTRIC DAM; ADULT STEELHEAD; SOCKEYE-SALMON; BYPASS SYSTEM AB We used ultrasound imaging and passive integrated transponder (PIT)-tagging programs to assess maturation status and iteroparity patterns in summer-run steelhead (anadromous rainbow trout, Oncorhynchus mykiss) of the interior Columbia River Basin (Pacific Northwest, USA). Postspawn kelts examined in downstream fish bypass systems at Columbia River and Snake River dams were disproportionately female (> 80%) and majorities were of wild origin, unlike prespawn steelhead at these sites. Annual repeat migration estimates varied from 2.9% to 9.0% for kelts tagged at lower Columbia River dams (n = 2542) and from 0.5% to 1.2% for Snake River kelts (n = 3762). Among-site differences reflected greater outmigration distance and additional dam passage hazards for Snake River kelts. There was also strong evidence for condition-dependent mortality, with returns an order of magnitude higher for good-versus poor-condition kelts. Disproportionately more females and wild fish also returned, providing potentially valuable genetic and demographic benefits for the Columbia River's threatened steelhead populations. Results overall provide baseline data for evaluating kelt mortality mitigation efforts and basic life history information for steelhead conservation planning. C1 [Keefer, Matthew L.; Boggs, Charles T.; Peery, Christopher A.] Univ Idaho, Dept Fish & Wildlife Resources, Moscow, ID 83844 USA. [Wertheimer, Robert H.] USA, Corps Engineers, Portland, OR 97208 USA. [Evans, Allen F.] Real Time Res Inc, Bend, OR 97702 USA. RP Keefer, ML (reprint author), Univ Idaho, Dept Fish & Wildlife Resources, Moscow, ID 83844 USA. EM mkeefer@uidaho.edu NR 79 TC 31 Z9 31 U1 2 U2 20 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 0706-652X EI 1205-7533 J9 CAN J FISH AQUAT SCI JI Can. J. Fish. Aquat. Sci. PD DEC PY 2008 VL 65 IS 12 BP 2592 EP 2605 DI 10.1139/F08-160 PG 14 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 386UT UT WOS:000261908800004 ER PT J AU Amin, A Benavides, LC Holmes, JP Gates, JD Carmichael, MG Hueman, MT Mittendorf, EA Storrer, CE Jama, YH Craig, D Stojadinovic, A Ponniah, S Peoples, GE AF Amin, Asna Benavides, Linda C. Holmes, Jarrod P. Gates, Jeremy D. Carmichael, Mark G. Hueman, Matthew T. Mittendorf, Elizabeth A. Storrer, Catherine E. Jama, Yusuf H. Craig, Dianna Stojadinovic, Alex Ponniah, Sathibalan Peoples, George E. TI Assessment of immunologic response and recurrence patterns among patients with clinical recurrence after vaccination with a preventive HER2/neu peptide vaccine: from US Military Cancer Institute Clinical Trials Group Study I-01 and I-02 SO CANCER IMMUNOLOGY IMMUNOTHERAPY LA English DT Article DE vaccine; E75 peptide; preventive; recurrence; pathologic patterns; immunologic response ID HER2-POSITIVE BREAST-CANCER; ADJUVANT CHEMOTHERAPY; METASTATIC BREAST; OVARIAN-CANCER; E75 VACCINE; T-CELLS; HER-2/NEU; IMMUNITY; IMMUNIZATION; TRASTUZUMAB AB Background E75, a HER2/neu immunogenic peptide, is expressed in breast cancer (BCa). We have performed clinical trials of E75 + GM-CSF vaccine in disease-free, node-positive and node-negative BCa patients at high recurrence risk and recurrences were noted in both control and vaccine groups. Methods Among the 186 BCa patients enrolled, 177 completed the study. Patients were HLA typed; the HLA-A2(+)/A3(+) patients were vaccinated; HLA-A2(-)/A3(-) patients were followed as controls. Standard clinicopathological factors, immunologic response to the vaccine, and recurrences were collected and assessed. Results The control group recurrence rate was 14.8 and 8.3% in the vaccinated group (P = 0.17). Comparing the 8 vaccinated recurrences (V-R) to the 88 vaccinated nonrecurrent patients (V-NR), the V-R group had higher nodal stage (>= N2: 75 vs. 5%, P = 0.0001) and higher grade tumors (% grade 3: 88 vs. 31%, P = 0.003). The V-R group did not fail to respond immunologically as noted by equivalent dimer responses and post-DTH responses. Compared to control recurrent patients (C-R), V-R patients trended toward higher-grade tumors and hormone-receptor negativity. C-R patients had 50% bone-only recurrences, compared to V-R patients with no bone-only recurrences (P = 0.05). Lastly, V-R mortality rate was 12.5% compared with 41.7% for the C-R group (P = 0.3). Conclusions The vaccinated patients who recurred had more aggressive disease compared to V-NR patients. V-R patients had no difference in immune response to the vaccine either in vitro or in vivo. V-R patients, when compared to C-R patients, trended towards more aggressive disease, decreased recurrence rates, decreased mortality, and no bone-only recurrences. C1 [Benavides, Linda C.; Gates, Jeremy D.; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Amin, Asna; Stojadinovic, Alex] Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, Washington, DC 20307 USA. [Holmes, Jarrod P.] USN, San Diego Med Ctr, Div Hematol & Med Oncol, Dept Med, San Diego, CA 92152 USA. [Carmichael, Mark G.; Hueman, Matthew T.; Storrer, Catherine E.; Jama, Yusuf H.; Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD 20814 USA. [Mittendorf, Elizabeth A.] UTMD Anderson Canc Ctr, Houston, TX USA. [Craig, Dianna] Windber Med Ctr, Joyce Murtha Breast Care Ctr, Windber, PA USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil NR 33 TC 18 Z9 19 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0340-7004 J9 CANCER IMMUNOL IMMUN JI Cancer Immunol. Immunother. PD DEC PY 2008 VL 57 IS 12 BP 1817 EP 1825 DI 10.1007/s00262-008-0509-2 PG 9 WC Oncology; Immunology SC Oncology; Immunology GA 351GI UT WOS:000259412300007 PM 18392824 ER PT J AU Hermone, AR Burnett, JC Nuss, JE Tressler, LE Nguyen, TL Solaja, BA Vennerstrom, JL Schmidt, JJ Wipf, P Bavari, S Gussio, R AF Hermone, Ann R. Burnett, James C. Nuss, Jonathan E. Tressler, Lyal E. Nguyen, Tam L. Solaja, Bogdan A. Vennerstrom, Jonathan L. Schmidt, James J. Wipf, Peter Bavari, Sina Gussio, Rick TI Three-Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three-Zone Pharmacophore SO CHEMMEDCHEM LA English DT Article DE molecular modeling; screening; drug discovery; biologically active compounds; botulinum neurotoxin ID TOXIN TYPE-A; ZINC ENDOPEPTIDASE; NEUROTRANSMITTER RELEASE; CLOSTRIDIUM-BOTULINUM; PROTEOLYTIC ACTIVITY; PROTEASE INHIBITORS; UNLABELED USES; VAMP/SYNAPTOBREVIN; CHEMISTRY; THERAPY AB A search query consisting of two aromatic centers and two cationic centers was defined based on previously identified small molecule inhibitors of the botulinum neurotoxin serotype A light chain (BoNT/A LC) and used to mine the National Cancer Institute Open Repository. Ten small molecule hits were identified, and upon testing, three demonstrated inhibitory activity. Of these, one was structurally unique, possessing a rigid diazochrysene scaffold. The steric limitations of the diazachrysene imposed a separation between the overlaps of previously identified inhibitors, revealing an extended binding mode. As a result, the pharmacophore for BoNT/A LC inhibition has been modified to encompass three zones. To demonstrate the utility of this model, a novel three-zone inhibitor was mined and its activity was confirmed. C1 [Hermone, Ann R.; Burnett, James C.; Nguyen, Tam L.] NCI, SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Frederick, MD 21702 USA. [Nuss, Jonathan E.; Tressler, Lyal E.; Schmidt, James J.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade 11001, Serbia. [Vennerstrom, Jonathan L.] Univ Nebraska Med Ctr, Coll Pharm, Omaha, NE 68198 USA. [Wipf, Peter] Univ Pittsburgh, Combinatorial Chem Ctr, Pittsburgh, PA 15260 USA. [Gussio, Rick] NCI, Informat Technol Branch, Dev Therapeut Program, Frederick, MD 21702 USA. RP Hermone, AR (reprint author), NCI, SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, POB 8, Frederick, MD 21702 USA. EM sina.bavari@us.army.mil; gussio@ncifcrf.gov OI Solaja, Bogdan/0000-0002-9975-2725 FU Defense Threat Reduction Agency [3.10024 06]; MRMC; NCI; National Institutes of Health; National Cancer Institute [N01-CO-12400] FX This research was funded by Defense Threat Reduction Agency project 3.10024 06 RD B and Interagency Agreement Y3 CM 100505 (MRMC and NCI, National Institutes of Health). Additionally, this project has been funded in whole or in port with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported [in part] by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. NR 46 TC 28 Z9 28 U1 0 U2 3 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1860-7179 J9 CHEMMEDCHEM JI ChemMedChem PD DEC PY 2008 VL 3 IS 12 BP 1905 EP 1912 DI 10.1002/cmdc.200800241 PG 8 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 386IO UT WOS:000261877100011 PM 19006141 ER PT J AU Ricart, AD Tolcher, AW Liu, G Holen, K Chwartz, GS Albertini, M Weiss, G Yazji, S Ng, C Wilding, G AF Ricart, Alejandro D. Tolcher, Anthony W. Liu, Glenn Holen, Kyle Schwartz, Garry Albertini, Mark Weiss, Geoffrey Yazji, Salim Ng, Chee Wilding, George TI Volociximab, a Chimeric Monoclonal Antibody that Specifically Binds alpha(5)beta(1) Integrin: A Phase I, Pharmacokinetic, and Biological Correlative Study SO CLINICAL CANCER RESEARCH LA English DT Article; Proceedings Paper CT 16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics CY SEP 28-OCT 01, 2004 CL Geneva, SWITZERLAND SP EORTC, NCI, AACR ID CYTOPLASMIC DOMAIN; MELANOMA-CELLS; FIBRONECTIN; EXPRESSION; ALPHA-5-BETA-1; ANGIOGENESIS; TRASTUZUMAB; ENVIRONMENT; INHIBITION; SURVIVAL AB Purpose: This study aimed to assess the safety and feasibility of administering volociximab, a chimeric monoclonal antibody that specifically binds to alpha(5)beta(1) integrin, and to determine the pharmacokinetics, pharmacodynamics, and preliminary evidence of antitumor activity. Experimental Design: Patients with advanced solid malignancies were treated with escalating doses of volociximab i.v. administered over 60 minutes. Blood samples were assayed to determine plasma pharmacokinetic parameters, detect human antichimeric antibody formation, and determine the saturation of alpha(5)beta(1) sites on peripheral blood monocytes. Results: Twenty-one patients received 223 infusions of volociximab at doses ranging from 0.5 to 15 mg/kg i.v. on days 1, 15, 22, 29, and 36; and weekly thereafter. Treatment was well tolerated, and dose-limiting toxicity was not identified over the range examined. Mild (grade 1 or 2), reversible fatigue was the principal toxicity of volociximab at the highest dose levels of 10 and 15 mg/kg. Nausea, fever, anorexia, headache, vomiting, and myalgias were mild and infrequent, and there was no hematologic toxicity. Volociximab had biexponential distribution; clearance was inversely related to increasing dose, and the half-life at 15 mg/kg was estimated as being 30 days. Three patients tested positive for anti-volociximab antibodies. Saturation of monocyte alpha(5)beta(1) integrin sites was dose-dependent up to 15 mg/kg. There was one minor response (renal, 7 months) and one durable stable disease (melanoma, 14 months). Conclusions: Volociximab can be safely administered at 15 mg/kg i.v. per week. The absence of severe toxicities and preliminary activity at the highest dose level warrants further disease-directed studies. C1 [Ricart, Alejandro D.; Tolcher, Anthony W.; Weiss, Geoffrey; Ng, Chee] Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA. [Ricart, Alejandro D.; Tolcher, Anthony W.; Weiss, Geoffrey; Ng, Chee] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Schwartz, Garry] Brooke Army Med Ctr, San Antonio, TX USA. [Liu, Glenn; Holen, Kyle; Albertini, Mark; Wilding, George] Univ Wisconsin, Paul P Carbone Comprehens Canc Ctr, Madison, WI USA. [Yazji, Salim] PDL Biopharma Inc, Fremont, CA USA. RP Tolcher, AW (reprint author), START Inst S Texas Accelerated Res Therapeut, 4319 Med Dr,Suite 205, San Antonio, TX 78229 USA. EM atolcher@start.stoh.com FU NCI NIH HHS [P30 CA014520-36, P30 CA014520-37, P30 CA014520, P30 CA014520-38] NR 28 TC 77 Z9 79 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD DEC 1 PY 2008 VL 14 IS 23 BP 7924 EP 7929 DI 10.1158/1078-0432.CCR-08-0378 PG 6 WC Oncology SC Oncology GA 379JK UT WOS:000261392300043 PM 19047123 ER PT J AU Brown, JM Berkey, BD Brooks, JA AF Brown, Jerry M. Berkey, Bryan D. Brooks, John A. TI Discovery of a Renal Medullary Carcinoma in an Adolescent Male With Sickle Cell Trait by Tc-99m Methylene Disphosponate Bone Scintigraphy SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE renal medullary carcinoma; sickle cell trait; hemoglobin SC disease; bone scintigraphy ID SCANS AB The renal excretion of Tc-99m bone imaging agents often permits the identification of urinary tract abnormalities on bone scans. In this case report, identification of focal intrarenal stasis of the excreted bone imaging agent led to additional anatomic imaging and the identification of a renal medullary carcinoma (RMC) in an adolescent black male undergoing evaluation for back pain. RMC is a rare, highly aggressive renal neoplasm found almost exclusively in young individuals with sickle cell trait (SCT) or hemoglobin SC disease. The prognosis of RMC is poor because the malignancy is usually refractory to chemotherapy and radiotherapy, with metastatic disease commonly present at the time of diagnosis. C1 [Brown, Jerry M.; Berkey, Bryan D.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. [Brooks, John A.] Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA. RP Brown, JM (reprint author), Tripler Army Med Ctr, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jerry.brown@amedd.army.mil NR 8 TC 1 Z9 1 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD DEC PY 2008 VL 33 IS 12 BP 896 EP 900 DI 10.1097/RLU.0b013e31818bf31d PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 376VS UT WOS:000261211700024 PM 19033803 ER PT J AU Banks, KP Song, WS AF Banks, Kevin P. Song, Won S. TI Acetabular Impingement on Planar and SPECT Bone Scintigraphy SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE scintigraphy; hip pain; femoroacetabular impingement (FAI) ID MR ARTHROGRAPHIC FINDINGS; FEMOROACETABULAR IMPINGEMENT; HIP; CAM AB A 37-year-old male presented with 4 months of atraumatic left hip pain. Onset of symptoms began during basic military training and pain was exacerbated by physical activity. Plain film radiographs of the hip were reported as normal. Because of the concern for a potential stress fracture, the patient was referred to nuclear medicine for bone scintigraphy. Planar and SPECT imaging revealed the presence of abnormal scintigraphic activity involving both hips (left greater than right) in a distribution atypical for stress injury and more consistent with bilateral femoral acetabular impingement (FAI). Subsequent MR examination was confirmed the diagnosis. This case illustrates a novel method for evaluating the physiologic process of FAI. C1 [Banks, Kevin P.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Nucl Med, Ft Sam Houston, TX 78234 USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM KPBanks@gmail.com NR 9 TC 1 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD DEC PY 2008 VL 33 IS 12 BP 916 EP 919 DI 10.1097/RLU.0b013e31818c4e6c PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 376VS UT WOS:000261211700030 PM 19033809 ER PT J AU Potter, BK Adams, SC Pitcher, JD Temple, HT AF Potter, Benjamin K. Adams, Sheila C. Pitcher, J. David, Jr. Temple, H. Thomas TI Local Recurrence of Disease after Unplanned Excisions of High-grade Soft Tissue Sarcomas SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID LIMB-SPARING SURGERY; RADIATION-THERAPY; RE-EXCISION; SUBCUTANEOUS SARCOMA; SURGICAL RESECTION; ANATOMIC LOCATION; RESIDUAL DISEASE; LOWER-EXTREMITY; SURVIVAL; MANAGEMENT AB Unplanned excisions of soft tissue sarcomas occur with alarming frequency and result in high rates of residual disease, potentially affecting patient prognosis. To determine if unplanned excisions and residual disease status at tumor bed excision increased local recurrence rates and predicted disease-specific patient survival, we retrospectively reviewed 203 consecutive patients with highgrade soft tissue sarcomas treated operatively and followed for at least 2 years (mean, 4.8 years) or until patient death. Among the 64 patients (32%) who had undergone previous unplanned excisions, six had gross residual disease and 40 of the remaining 58 (69%) had microscopic residual disease in the tumor bed. We observed subsequent local recurrence in nine of the 139 patients (6%) after planned excision compared with 22 patients (34%) after unplanned excision. More patients with unplanned excisions who underwent limb salvage procedures required flap coverage and/or skin grafting with their definitive resection (30% versus 5%). In the unplanned excision cohort, residual disease status at tumor bed excision predicted increased rates of local recurrence and decreased disease-specific survival. Unplanned excisions of high-grade soft tissue sarcomas resulted in increased rates of local recurrence but not disease-specific survival. Residual disease at reexcision predicted the likelihood of local recurrence. C1 [Potter, Benjamin K.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Temple, H. Thomas] Univ Miami, Miller Sch Med, Dept Orthopaed, Miami, FL 33136 USA. RP Potter, BK (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, 6900 Georgia Ave NW,Bldg 2A,Room 205, Washington, DC 20307 USA. EM Benjamin.potter@amedd.army.mil OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 46 TC 35 Z9 35 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD DEC PY 2008 VL 466 IS 12 BP 3093 EP 3100 DI 10.1007/s11999-008-0529-4 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 383RG UT WOS:000261690500026 PM 18818981 ER PT J AU Uzarski, JR Tannous, A Morris, JR Mello, CM AF Uzarski, Joshua R. Tannous, Abla Morris, John R. Mello, Charlene M. TI The effects of solution structure on the surface conformation and orientation of a cysteine-terminated antimicrobial peptide cecropin P1 SO COLLOIDS AND SURFACES B-BIOINTERFACES LA English DT Article DE Antimicrobial peptide; Surface structure ID INFRARED REFLECTION ABSORPTION; VIBRATIONAL SPECTROSCOPY; GOLD SURFACE; HYDROPHOBIC POLYSTYRENE; MOLECULAR-CONFORMATION; HYDROPHILIC SILICA; PROTEIN-STRUCTURE; ESCHERICHIA-COLI; ADSORPTION; MONOLAYERS AB The surface structure of an antimicrobial peptide, cecropin P1, immobilized to a gold surface via a terminal cysteine residue was investigated. Using reflection-absorption infrared spectroscopy, surface plasmon resonance, and X-ray photoelectron spectroscopy, the effects of pH,solution conformation, and concentration on the immobilized peptide conformation, average orientation, and surface density were determined. Under all conditions investigated, the immobilized peptides were a-helical in a predominately flat, random orientation. The addition of the reducing agent Tris(2-carboxyethyl) phosphine hydrochloride to the buffer resulted in a twofold increase in immobilized peptide surface density. Published by Elsevier B.V. C1 [Mello, Charlene M.] USA, NSRDEC, Biosci & Technol Team, Natick, MA 01760 USA. [Uzarski, Joshua R.; Morris, John R.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA. [Tannous, Abla; Mello, Charlene M.] Univ Massachusetts, Dept Chem & Biochem, Dartmouth, MA 02743 USA. RP Mello, CM (reprint author), USA, NSRDEC, Biosci & Technol Team, Kansas St, Natick, MA 01760 USA. EM charlene.mello@us.army.mil FU U.S. Army NSRDEC [AH52] FX We respectfully thank Professors Bal Ram Singh and Shuowei Cai for the use of Jasco J-715 spectropolarimeter and valuable discussions. Special gratitude is alos extended to Dr. Jennifer Becker from the Army Research Office for technical and programmatic support. This research was supported by the U.S. Army NSRDEC AH52 basic research program. This manuscript has been approved for unlimited distribution by the U.S. Army Natick Soldier Research, Development and Engineering Center [PAO#08-208]. NR 52 TC 22 Z9 22 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-7765 J9 COLLOID SURFACE B JI Colloid Surf. B-Biointerfaces PD DEC 1 PY 2008 VL 67 IS 2 BP 157 EP 165 DI 10.1016/j.colsurfb.2008.07.011 PG 9 WC Biophysics; Chemistry, Physical; Materials Science, Biomaterials SC Biophysics; Chemistry; Materials Science GA 383HV UT WOS:000261665600002 PM 18945601 ER PT J AU Ahmad, FH Castellane, RM Miller, EL AF Ahmad, Falih H. Castellane, Ray M. Miller, Ernest L. TI On the applicability of the pseudospectral Legendre method for edge detection SO COMMUNICATIONS IN NUMERICAL METHODS IN ENGINEERING LA English DT Article DE pseudospectral method; gradient detector; edge detection AB The pseudospectral Legendre method is utilized to develop a gradient detector. This detector is proposed in this communication for the detection of edges in discrete images. The detector can be applied in both the horizontal and vertical directions. It is a separable detector where the smoothing orthogonal part resembles a one-dimensional notch filter. Discrete Canny's criteria values of the detector are similar to those of other known basic derivative filters. An example is given in which this detector is utilized and its applicability and validity are supported using comparison results from the use of the Sobel filter. Copyright (C) 2007 John Wiley & Sons, Ltd. C1 [Ahmad, Falih H.] Tarleton State Univ, Dept Math Phys & Engn, Stephenville, TX 76402 USA. [Castellane, Ray M.; Miller, Ernest L.] Engineer Res & Dev Ctr, Dept Army, Vicksburg, MS 39180 USA. RP Ahmad, FH (reprint author), Tarleton State Univ, Dept Math Phys & Engn, Box T-390, Stephenville, TX 76402 USA. EM ahmad@tarleton.edu FU Department of Defense, Engineering Research and Development Center. ERDC [W912HZ-06-P-0007] FX This work was Supported by the Department of Defense, Engineering Research and Development Center. ERDC, Vicksburg, Mississippi, U.S.A. under contract W912HZ-06-P-0007. The authors Would like to C extend their sincere thanks to Mrs Pamela Kinnebrew, Chief, Survivability Engineering Branch, ERDC. Z, C Permission was granted by the Chief of Engineers from ERDC to publish this information. NR 8 TC 0 Z9 0 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1069-8299 J9 COMMUN NUMER METH EN JI Commun. Numer. Methods Eng. PD DEC PY 2008 VL 24 IS 12 BP 1805 EP 1810 DI 10.1002/cnm.1068 PG 6 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA 384XY UT WOS:000261778700014 ER PT J AU Ku, BC Kim, DW Steeves, D Nagarajan, R Blumstein, A Kumar, J Gibson, PW Ratto, JA Samuelson, LA AF Ku, Bon-Cheol Kim, Dong Wook Steeves, Diane Nagarajan, Ramaswamy Blumstein, Alexandre Kumar, Jayant Gibson, Philip W. Ratto, Jo An Samuelson, Lynne A. TI Molecularly ordered structure and permeability properties of amphiphilic polyacetylene-multilayer nanocomposites SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Multilayer nanocomposites; Barrier membranes; Layer-by-layer assembly; Ionic polyacetylenes ID CONJUGATED IONIC POLYACETYLENES; LAYERED SILICATE NANOCOMPOSITES; ALUMINOSILICATE NANOPLATELETS; POLYMERIZATION; SYSTEMS AB Nanocomposite films consisting of. amphiphilic ionic polyacetylenes, (P2EPy-R) and layered aluminosilicates (saponite) have been prepared through electrostatic layer-by-layer assembly. The water vapor barrier properties of the nanocomposite films coated on Nafion (TM) film have been studied. The Nafion film coated with poly(N-octadecyl-2-ethynyloyridinium bromide) (P2EPy-C18) and aluminosilicates showed 22 times higher diffusion resistance to water vapor and 95% reduction in water vapor permeability when compared with the pristine Nafion control film. The X-ray diffraction data, UV-vis absorption spectroscopy, transmission electron microscopy (TEM), and atomic force microscopy (AFM) suggest a strong tendency of micellization of P2EPy-C18 polymer and ordered structure on the surface of aluminosilicate nanosheets compared to short alkyl side chains, C12, C6, and C0. The micellized and ordered structure of P2EPy-C18 between alummosilicate could explain the improved hydrophobic barrier properties of P2EPy-C18/aluminosilicate nanocomposites. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Kumar, Jayant] Univ Massachusetts, Dept Phys, Polymer Sci Plast Engn Program, Ctr Adv Mat, Lowell, MA 01854 USA. [Ku, Bon-Cheol; Nagarajan, Ramaswamy; Blumstein, Alexandre] Univ Massachusetts, Dept Chem, Polymer Sci Plast Engn Program, Ctr Adv Mat, Lowell, MA 01854 USA. [Kim, Dong Wook] Korea Res Inst Chem Technol, Adv Mat Div, Taejon 305600, South Korea. [Steeves, Diane; Gibson, Philip W.; Ratto, Jo An; Samuelson, Lynne A.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Dept Phys, Polymer Sci Plast Engn Program, Ctr Adv Mat, Lowell, MA 01854 USA. EM Jayant_Kumar@uml.edu RI Gibson, Phillip/D-2398-2010; OI Gibson, Phillip/0000-0002-6172-4438; KIM, DONG WOOK/0000-0002-0752-5366 FU US Army Natick Soldier Research, Development & Engineering Center FX We acknowledge the financial support of US Army Natick Soldier Research, Development & Engineering Center. The authors would like to thank M. Downey and A. Jain for technical advice for X-ray diffraction and atomic force microscopy. NR 26 TC 4 Z9 4 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 EI 1879-1050 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD DEC PY 2008 VL 68 IS 15-16 BP 3215 EP 3219 DI 10.1016/j.compscitech.2008.08.009 PG 5 WC Materials Science, Composites SC Materials Science GA 383JR UT WOS:000261670400021 ER PT J AU Tezduyar, TE Sathe, S Pausewang, J Schwaab, M Christopher, J Crabtree, J AF Tezduyar, Tayfun E. Sathe, Sunil Pausewang, Jason Schwaab, Matthew Christopher, Jason Crabtree, Jason TI Interface projection techniques for fluid-structure interaction modeling with moving-mesh methods SO COMPUTATIONAL MECHANICS LA English DT Article; Proceedings Paper CT Fluid-Structure Interaction Minisymposium CY JUN 05-07, 2007 CL Barcelona, SPAIN DE interface projection techniques; air-fabric interaction; fluid-structure interaction; space-time FSI technique; sails; parachutes ID FINITE-ELEMENT COMPUTATIONS; INCOMPRESSIBLE-FLOW COMPUTATIONS; NAVIER-STOKES EQUATIONS; SPACE-TIME PROCEDURE; BOUNDARY FLOWS; FORMULATION; PARACHUTE; SIMULATION; SYSTEMS; GEOMETRIES AB The stabilized space-time fluid-structure interaction (SSTFSI) technique developed by the Team for Advanced Flow Simulation and Modeling (T*AFSM) was applied to a number of 3D examples, including arterial fluid mechanics and parachute aerodynamics. Here we focus on the interface projection techniques that were developed as supplementary methods targeting the computational challenges associated with the geometric complexities of the fluid-structure interface. Although these supplementary techniques were developed in conjunction with the SSTFSI method and in the context of air-fabric interactions, they can also be used in conjunction with other moving-mesh methods, such as the Arbitrary Lagrangian-Eulerian (ALE) method, and in the context of other classes of FSI applications. The supplementary techniques currently consist of using split nodal values for pressure at the edges of the fabric and incompatible meshes at the air-fabric interfaces, the FSI Geometric Smoothing Technique (FSI-GST), and the Homogenized Modeling of Geometric Porosity (HMGP). Using split nodal values for pressure at the edges and incompatible meshes at the interfaces stabilizes the structural response at the edges of the membrane used in modeling the fabric. With the FSI-GST, the fluid mechanics mesh is sheltered from the consequences of the geometric complexity of the structure. With the HMGP, we bypass the intractable complexities of the geometric porosity by approximating it with an "equivalent", locally-varying fabric porosity. As test cases demonstrating how the interface projection techniques work, we compute the air-fabric interactions of windsocks, sails and ringsail parachutes. C1 [Tezduyar, Tayfun E.; Sathe, Sunil; Pausewang, Jason; Schwaab, Matthew; Christopher, Jason] Rice Univ, Houston, TX 77005 USA. [Crabtree, Jason] US Mil Acad, West Point, NY 10996 USA. RP Tezduyar, TE (reprint author), Rice Univ, MS 321,6100 Main St, Houston, TX 77005 USA. EM tezduyar@rice.edu RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 64 TC 86 Z9 86 U1 0 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0178-7675 J9 COMPUT MECH JI Comput. Mech. PD DEC PY 2008 VL 43 IS 1 BP 39 EP 49 DI 10.1007/s00466-008-0261-7 PG 11 WC Mathematics, Interdisciplinary Applications; Mechanics SC Mathematics; Mechanics GA 352RB UT WOS:000259514000003 ER PT J AU Tezduyar, TE Sathe, S Schwaab, M Pausewang, J Christopher, J Crabtree, J AF Tezduyar, Tayfun E. Sathe, Sunil Schwaab, Matthew Pausewang, Jason Christopher, Jason Crabtree, Jason TI Fluid-structure interaction modeling of ringsail parachutes SO COMPUTATIONAL MECHANICS LA English DT Article; Proceedings Paper CT Fluid-Structure Interaction Minisymposium CY JUN 05-07, 2007 CL Barcelona, SPAIN DE ringsail parachute; orion space vehicle; fluid-structure interaction; offloading; drifting ID FINITE-ELEMENT COMPUTATIONS; INCOMPRESSIBLE-FLOW COMPUTATIONS; NAVIER-STOKES EQUATIONS; MOVING BOUNDARY FLOWS; SPACE-TIME PROCEDURE; FORMULATION; SIMULATION; INTERFACES; SYSTEMS; GEOMETRIES AB In this paper, we focus on fluid-structure interaction (FSI) modeling of ringsail parachutes, where the geometric complexity created by the "rings" and "sails" used in the construction of the parachute canopy poses a significant computational challenge. It is expected that NASA will be using a cluster of three ringsail parachutes, referred to as the "mains", during the terminal descent of the Orion space vehicle. Our FSI modeling of ringsail parachutes is based on the stabilized space-time FSI (SSTFSI) technique and the interface projection techniques that address the computational challenges posed by the geometric complexities of the fluid-structure interface. Two of these interface projection techniques are the FSI Geometric Smoothing Technique and the Homogenized Modeling of Geometric Porosity. We describe the details of how we use these two supplementary techniques in FSI modeling of ringsail parachutes. In the simulations we report here, we consider a single main parachute, carrying one third of the total weight of the space vehicle. We present results from FSI modeling of offloading, which includes as a special case dropping the heat shield, and drifting under the influence of side winds. C1 [Tezduyar, Tayfun E.; Sathe, Sunil; Schwaab, Matthew; Pausewang, Jason; Christopher, Jason] Rice Univ, Houston, TX 77005 USA. [Crabtree, Jason] US Mil Acad W Point, New York, NY 10996 USA. RP Tezduyar, TE (reprint author), Rice Univ, MS 321,6100 Main St, Houston, TX 77005 USA. EM tezduyar@rice.edu RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 63 TC 65 Z9 67 U1 0 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0178-7675 J9 COMPUT MECH JI Comput. Mech. PD DEC PY 2008 VL 43 IS 1 BP 133 EP 142 DI 10.1007/s00466-008-0260-8 PG 10 WC Mathematics, Interdisciplinary Applications; Mechanics SC Mathematics; Mechanics GA 352RB UT WOS:000259514000012 ER PT J AU Thorp, KR DeJonge, KC Kaleita, AL Batchelor, WD Paz, JO AF Thorp, Kelly R. DeJonge, Kendall C. Kaleita, Amy L. Batchelor, William D. Paz, Joel O. TI Methodology for the use of DSSAT models for precision agriculture decision support SO COMPUTERS AND ELECTRONICS IN AGRICULTURE LA English DT Article DE Precision farming; Crop models; Prescriptions; DSSAT; Decision support system ID INCREASING CARBON-DIOXIDE; OCEAN-ATMOSPHERE MODEL; TRANSIENT-RESPONSE; YIELD VARIABILITY; MANAGEMENT; NITROGEN; CLIMATE; CORN; STRATEGIES; SOYBEANS AB A prototype decision support system (DSS) called Apollo was developed to assist researchers in using the Decision Support System for Agrotechnology Transfer (DSSAT) crop growth models to analyze precision farming datasets. Because the DSSAT models are written to simulate crop growth and development within a homogenous unit of land, the Apollo DSS has specialized functions to manage running the DSSAT models to simulate and analyze spatially variable land and management. The DSS has modules that allow the user to build model input files for spatial simulations across predefined management zones, calibrate the models to simulate historic spatial yield variability, validate the models for seasons not used for calibration, and estimate the crop response and environmental impacts of nitrogen, plant population, cultivar, and irrigation prescriptions. This paper details the functionality of Apollo, and presents the results of an example application. (C) 2008 Elsevier B.V. All rights reserved. C1 [Kaleita, Amy L.] Iowa State Univ, Dept Agr & Biosyst Engn, Ames, IA 50011 USA. [Thorp, Kelly R.] ARS, USDA, Maricopa, AZ USA. [DeJonge, Kendall C.] USA, Corps Engineers, Omaha, NE USA. [Batchelor, William D.] Mississippi State Univ, Mississippi State, MS 39762 USA. [Paz, Joel O.] Univ Georgia, Griffin, GA USA. RP Kaleita, AL (reprint author), Iowa State Univ, Dept Agr & Biosyst Engn, 211 Davidson Hall, Ames, IA 50011 USA. EM kaleita@iastate.edu RI Paz, Joel/F-7685-2010; Thorp, Kelly/C-2013-2009; Kaleita, Amy/J-8363-2016; OI Thorp, Kelly/0000-0001-9168-875X; Kaleita, Amy/0000-0002-8906-3408; Paz, Joel/0000-0003-0193-3681 NR 22 TC 25 Z9 26 U1 5 U2 32 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0168-1699 J9 COMPUT ELECTRON AGR JI Comput. Electron. Agric. PD DEC PY 2008 VL 64 IS 2 BP 276 EP 285 DI 10.1016/j.compag.2008.05.022 PG 10 WC Agriculture, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Agriculture; Computer Science GA 374WN UT WOS:000261074500020 ER PT J AU Dubick, MA Scherer, MR Darlington, DN Delgado, AV Martini, WZ Kheirabadi, BS AF Dubick, Michael A. Scherer, Michael R. Darlington, Daniel N. Delgado, Angel V. Martini, Wenjun Z. Kheirabadi, Bijan S. TI HEMOSTATIC EFFECTS OF RECOMBINANT ACTIVATED FACTOR VII (RFVIIA) IN ACIDOTIC AND PH CORRECTED SWINE. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 38th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 31-FEB 04, 2009 CL Nashville, TN SP Soc Crit Care Med C1 [Dubick, Michael A.; Scherer, Michael R.; Darlington, Daniel N.; Delgado, Angel V.; Martini, Wenjun Z.; Kheirabadi, Bijan S.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2008 VL 36 IS 12 SU S MA 445 BP A110 EP A110 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 376WM UT WOS:000261213700410 ER PT J AU Holt, DB Delaney, RR Hashim, G Sato, A Hernandez, C Uyehara, CF AF Holt, Danielle B. Delaney, Richard R. Hashim, Glenn Sato, Aileen Hernandez, Claudia Uyehara, Catherine F. TI ADRENAL INSUFFICIENCY MAY PREDICT NON-RESPONSIVENESS TO DOBUTAMINE STRESS TEST IN SEPTIC SHOCK. SO CRITICAL CARE MEDICINE LA English DT Meeting Abstract CT 38th Critical Care Congress of the Society-of-Critical-Care-Medicine CY JAN 31-FEB 04, 2009 CL Nashville, TN SP Soc Crit Care Med C1 [Holt, Danielle B.; Delaney, Richard R.; Hashim, Glenn; Sato, Aileen; Hernandez, Claudia; Uyehara, Catherine F.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2008 VL 36 IS 12 SU S MA 176 BP A40 EP A40 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA 376WM UT WOS:000261213700144 ER PT J AU Logemann, JA Rademaker, A Pauloski, BR Antinoja, J Bacon, M Bernstein, M Gaziano, J Grande, B Kelchner, L Kelly, A Klaben, B Lundy, D Newman, L Santa, D Stachowiak, L Stangl-McBreen, C Atkinson, C Bassani, H Czapla, M Farquharson, J Larsen, K Lewis, V Logan, H Nitschke, T Veis, S AF Logemann, Jeri A. Rademaker, Alfred Pauloski, Barbara Roa Antinoja, Jodi Bacon, Mary Bernstein, Michelle Gaziano, Joy Grande, Barbara Kelchner, Lisa Kelly, Amy Klaben, Bernice Lundy, Donna Newman, Lisa Santa, Daphne Stachowiak, Linda Stangl-McBreen, Carrie Atkinson, Cory Bassani, Heidi Czapla, Melissa Farquharson, Julie Larsen, Kristin Lewis, Vicki Logan, Heather Nitschke, Teri Veis, Sharon TI What Information Do Clinicians Use in Recommending Oral versus Nonoral Feeding in Oropharyngeal Dysphagic Patients? SO DYSPHAGIA LA English DT Article DE Oral feeding; Nonoral feeding; Videofluoroscopy; Oropharyngeal dysphagia; Deglutition; Deglutition disorders ID RELATIVE RISK; PNEUMONIA; ASPIRATION; STROKE AB There is little evidence regarding the type(s) of information clinicians use to make the recommendation for oral or nonoral feeding in patients with oropharyngeal dysphagia. This study represents a first step toward identifying data used by clinicians to make this recommendation and how clinical experience may affect the recommendation. Thirteen variables were considered critical in making the oral vs. nonoral decision by the 23 clinicians working in dysphagia. These variables were then used by the clinicians to independently recommend oral vs. nonoral feeding or partial oral with nonoral feeding for the 20 anonymous patients whose modified barium swallows were sent on a videotape to each clinician. Clinicians also received data on the 13 variables for each patient. Results of clinician agreement on the recommendation of full oral and nonoral only were quite high, as measured by Kappa statistics. In an analysis of which of the 13 criteria clinicians used in making their recommendations, amount of aspiration was the criterion with the highest frequency. Recommendations for use of postures and maneuvers and the effect of clinician experience on these choices were also analyzed. C1 [Logemann, Jeri A.; Pauloski, Barbara Roa] Northwestern Univ, Dept Commun Sci & Disorders, Evanston, IL 60208 USA. [Rademaker, Alfred] Northwestern Univ, Dept Prevent Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA. [Antinoja, Jodi] Froedtert Mem Lutheran Hosp, Milwaukee, WI 53226 USA. [Bacon, Mary] Edward Hines Vet Adm Med Ctr, Hines, IL 60141 USA. [Bernstein, Michelle; Lundy, Donna] Univ Miami, Hosp Med Ctr, Dept Otolaryngol, Miami, FL 33136 USA. [Gaziano, Joy; Stachowiak, Linda; Czapla, Melissa; Lewis, Vicki] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA. [Grande, Barbara] St Joseph Reg Med Ctr, Milwaukee, WI 53210 USA. [Kelchner, Lisa] Univ Cincinnati, CAHS Commun Sci & Disorders, Cincinnati, OH 45267 USA. [Kelly, Amy] Evanston NW Healthcare, Speech Pathol Dept, Evanston, IL 60201 USA. [Klaben, Bernice] Blaine Block Inst Voice Anal & Rehabil, Dayton, OH 45402 USA. [Newman, Lisa; Bassani, Heidi] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Santa, Daphne] Miami VA Med Ctr, Miami, FL 33125 USA. [Stangl-McBreen, Carrie; Atkinson, Cory; Farquharson, Julie; Larsen, Kristin; Logan, Heather; Veis, Sharon] NW Mem Hosp, Chicago, IL 60611 USA. [Nitschke, Teri] Zablocki Vet Adm Med Ctr, Milwaukee, WI 53295 USA. RP Logemann, JA (reprint author), Northwestern Univ, Dept Commun Sci & Disorders, 2240 N Campus Dr,Room 3-358, Evanston, IL 60208 USA. EM j-logemann@northwestern.edu FU NCRR NIH HHS [UL1 RR031973]; NIDDK NIH HHS [R01 DK062178, R01 DK062178-03] NR 11 TC 5 Z9 6 U1 1 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0179-051X J9 DYSPHAGIA JI Dysphagia PD DEC PY 2008 VL 23 IS 4 BP 378 EP 384 DI 10.1007/s00455-008-9152-5 PG 7 WC Otorhinolaryngology SC Otorhinolaryngology GA 372YT UT WOS:000260938900005 PM 18670808 ER PT J AU VanNimwegen, RE Kretzer, J Cully, JF AF VanNimwegen, Ron E. Kretzer, Justin Cully, Jack F., Jr. TI ECOSYSTEM ENGINEERING BY A COLONIAL MAMMAL: HOW PRAIRIE DOGS STRUCTURE RODENT COMMUNITIES SO ECOLOGY LA English DT Article DE black-tailed prairie dogs; community composition; Cynomys spp.; ecosystem engineer; nonmetric multidimensional scaling; ordination; rodents; vegetation structure ID BLACK-TAILED PRAIRIE; MIXED-GRASS PRAIRIE; SHORTGRASS-PRAIRIE; SPECIES-DIVERSITY; ORGANISMS; LANDSCAPE AB As ecosystem engineers, prairie dogs (Cynomys spp.) physically alter their environment, but the mechanism by which these alterations affect associated faunal composition is not well known. We examined how rodent and vegetation communities responded to prairie dog colonies and landcover at the Cimarron National Grassland in southwest Kansas, USA. We trapped rodents and measured vegetation structure on and off colonies in 2000 and 2003. We plotted two separate ordinations of trapping grids: one based on rodent counts and a second based on vegetation variables. We regressed three factors on each ordination: (1) colony (on-colony and off-colony), (2) cover (shortgrass and sandsage), and (3) habitat (factorial cross of colony X cover). Rodent communities differed by colony but not cover. Vegetation differed across both gradients. Rodent responses to habitat reflected those of colony and cover, but vegetation was found to differ across cover only in the sandsage prairie. This interaction suggested that rodent composition responded to prairie dog colonies, but independently of vegetation differences. We conclude that burrowing and soil disturbance are more important than vegetation cropping in structuring rodent communities. C1 [VanNimwegen, Ron E.; Cully, Jack F., Jr.] Kansas State Univ, Div Biol, Manhattan, KS 66506 USA. [Kretzer, Justin] ITAM, Ft Sill, OK 73503 USA. [Cully, Jack F., Jr.] Kansas State Univ, US Geol Survey, Kansas Cooperat Fish & Wildlife Res Unit, Manhattan, KS 66506 USA. RP VanNimwegen, RE (reprint author), Kansas State Univ, Div Biol, Ackert Hall, Manhattan, KS 66506 USA. EM vanron@ksu.edu FU U. S. Fish and Wildlife Service; U. S. Forest Service; Kansas Cooperative Fish and Wildlife Research Unit; Division of Biology of Kansas State University FX Funding for this report was funded by the U. S. Fish and Wildlife Service, U. S. Forest Service, Kansas Cooperative Fish and Wildlife Research Unit, and the Division of Biology of Kansas State University. E. Agner, P. Lemons, D. Martin, S. Meyers, M. Wong, J. Wertz, D. Winslow, S. Winter, and B. Thiagarajan provided extensive field assistance and data entry. P. Stapp, C. Paukert, and two anonymous reviewers provided reviews and valuable comments. NR 35 TC 22 Z9 22 U1 6 U2 29 PU ECOLOGICAL SOC AMER PI WASHINGTON PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA SN 0012-9658 J9 ECOLOGY JI Ecology PD DEC PY 2008 VL 89 IS 12 BP 3298 EP 3305 DI 10.1890/07-1511.1 PG 8 WC Ecology SC Environmental Sciences & Ecology GA 381GP UT WOS:000261524000006 PM 19137937 ER PT J AU Veerappan, GR Koff, JM Smith, MT AF Veerappan, G. R. Koff, J. M. Smith, M. T. TI Enteryx polymer migration to lymph nodes and beyond SO ENDOSCOPY LA English DT Editorial Material C1 [Veerappan, G. R.; Koff, J. M.; Smith, M. T.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. RP Veerappan, GR (reprint author), Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM ganesh.veerappan@amedd.army.mil NR 3 TC 1 Z9 1 U1 0 U2 0 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0013-726X EI 1438-8812 J9 ENDOSCOPY JI Endoscopy PD DEC PY 2008 VL 40 SU 2 BP E10 EP E11 DI 10.1055/s-2007-995391 PG 2 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA V42SV UT WOS:000209634400006 PM 18278711 ER PT J AU Best, EPH Tatem, HE Geter, KN Wells, ML Lane, BK AF Best, Elly P. H. Tatem, Henry E. Geter, Kaaren N. Wells, Melissa L. Lane, Brian K. TI EFFECTS, UPTAKE, AND FATE OF 2,4,6-TRINITROTOLUENE AGED IN SOIL IN PLANTS AND WORMS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE 2,4,6-Trinitrotoluene; Aged; Bioavailability; Plants; Worms ID ARMY AMMUNITION PLANT; SANDY LOAM SOIL; EISENIA-ANDREI; TNT; RDX; PHYTOTOXICITY; EXPLOSIVES; TOXICITY AB The present study was aimed at providing data to be used at predicting exposure-based effects of 2,4,6-trinitrotoluene (TNT) aged in soil on endpoint organisms representing two trophic levels. These data can be used to define criteria or reference values for environmental management and conducting specific risk assessment. Long-term exposure tests were conducted to evaluate sublethal toxicity and uptake of aged soil-based explosives, with TNT as the main contaminant. In these tests, plants were exposed for 55 d, and biomass and explosives residues were determined. Worms were exposed for 28 and 42 d, and biomass, number, and tissue residues were determined. Biomass of Lolium perenne significantly decreased with soil-TNT concentration, and an effective concentration causing a 20% decrease in biomass (EC20) for TNT metabolites of 3.75 mg/kg was calculated. The concentrations of TNT metabolites in shoots and roots were significantly related to concentrations in soil, as were concentrations of hexahydro-1,3,5-trinitro-1,3,5 triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). The mean bioconcentration factors, indicating the potential of a chemical to accumulate in an organism, were 0.9 for TNT metabolites, 71.8 for RDX, and 12.2 for HMX in L. perenne shoots. Biomass of Eisenia fetida adults significantly decreased with soil-TNT concentration, and an EC20 for TNT of 3.70 mg/kg was calculated. The TNT, RDX, and HMX levels in E. fetida were below detection. C1 [Best, Elly P. H.; Tatem, Henry E.; Wells, Melissa L.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Geter, Kaaren N.] Analyt Serv, Vicksburg, MS 39180 USA. RP Best, EPH (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM elly.p.best@erdc.usace.army.mil FU U. S. Army Corps of Engineers Environmental Quality Technology Program; Army Environmental Research and Development Center's Project Bioavailability, Uptake, Toxicity; Transfer Across Trophic Levels of TNT; RDX in Aged Soil; Margaret Richmond (Analytical Services) FX This research was funded by the U. S. Army Corps of Engineers Environmental Quality Technology Program. The present work was part of the Army Environmental Research and Development Center's Project Bioavailability, Uptake, Toxicity, and Transfer Across Trophic Levels of TNT and RDX in Aged Soil. Margaret Richmond (Analytical Services) provided partial technical NR 33 TC 14 Z9 14 U1 0 U2 9 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD DEC PY 2008 VL 27 IS 12 BP 2539 EP 2547 DI 10.1897/08-017.1 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 393UQ UT WOS:000262399300016 PM 18620472 ER PT J AU Best, EPH Hintelmann, H Dimock, B Bednar, AJ AF Best, Elly P. H. Hintelmann, Holger Dimock, Brian Bednar, Anthony J. TI Natural Cycles and Transfer of Mercury Through Pacific Coastal Marsh Vegetation Dominated by Spartina foliosa and Salicornia virginica SO ESTUARIES AND COASTS LA English DT Article DE Mercury; Monomethylmercury; Salt marsh; Estuarine; Spartina; Salicornia ID SAN-FRANCISCO-BAY; SALT-MARSH; FOOD-WEBS; PHRAGMITES-AUSTRALIS; ALTERNIFLORA LOISEL; STABLE-ISOTOPES; DETRITUS; ESTUARY; WETLAND; PLANTS AB The potential for marsh plants to be vectors in the transport of mercury species was studied in the natural, mature, tidal China Camp salt marsh on San Pablo Bay. The fluxes of organic matter, mercury (THg), and monomethylmercury (MeHg) were studied in natural stands of Spartina foliosa and Salicornia virginica. Seasonal fluxes from the sediment into aboveground biomass of live plants and subsequent transfer into the dead plant community by mortality were measured. Loss of THg and MeHg from the dead plant community through fragmentation, leaching, and excretion were calculated and were similar to net uptake. Seasonal data were added up to calculate annual mass balances. In S. foliosa, annual net production was 1,757 g DW m2, and the annual net uptakes in the aboveground biomass were 305 mu g THg m2 and 5.720 mu g MeHg m-2. In S. virginica, annual net production was 2,117 g DW m2, and the annual net uptakes in aboveground biomass were 99.120 mu g THg m-2 and 1.990 mu g MeHg m-2. Of both plant species studied, S. foliosa had a slightly lower production rate but greater mercury species uptake and loss rates than S. virginica, and, consequently, it is to be expected that S. foliosa matter may affect the local and possibly the regional food web relatively more than S. virginica. However, the actual effects of the input of mercury-species-containing plant-derived particulate matter into the food webs would depend on trophic level, food preference, seasonal cycle of the consumer, total sediment surface area vegetated, location of the vegetation in the marsh landscape, and estuary bay landscape. Since the levels of mercury species in dead plant material greatly exceed those in live plant material (on a dry weight basis), detritivores would ingest greater mercury species concentrations than herbivores, and consumers of S. foliosa would ingest more than consumers of S. virginica. The greatest THg and MeHg losses of both plant species due to mortality and to fragmentation-leaching-excretion occurred in late spring and early autumn, which corresponds to peak MeHg levels observed in sediments of coastal systems of previous studies, suggesting enhanced THg-MeHg export from the marsh to the nearshore sediment. C1 [Best, Elly P. H.; Bednar, Anthony J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Hintelmann, Holger; Dimock, Brian] Trent Univ, Dept Chem, Peterborough, ON K9J 7B8, Canada. RP Best, EPH (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM elly.p.best@usace.army.mil OI Hintelmann, Holger/0000-0002-5287-483X FU Long-Term Management Strategy; US Army Corps of Engineers (USACE) FX This research was supported by the Long-Term Management Strategy, administered by the US Army Corps of Engineers (USACE) San Francisco District, awarded for the project "Transfer of mercury from primary producers to consumers-quantifying the entry of mercury into the aquatic food web" to E. P. H. Best. Best has full control of all primary data and agrees to allow the journal to review the data if requested. No potential conflict of interest exists. NR 58 TC 4 Z9 5 U1 2 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1559-2723 J9 ESTUAR COAST JI Estuaries Coasts PD DEC PY 2008 VL 31 IS 6 BP 1072 EP 1088 DI 10.1007/s12237-008-9086-z PG 17 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 369IA UT WOS:000260686700005 ER PT J AU Webb, HE Weldy, ML Fabianke-Kadue, EC Orndorff, GR Kamimori, GH Acevedo, EO AF Webb, Heather E. Weldy, Michael L. Fabianke-Kadue, Emily C. Orndorff, G. R. Kamimori, Gary H. Acevedo, Edmund O. TI Psychological stress during exercise: cardiorespiratory and hormonal responses SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Exercise; physiology; Exercise; psychology; Mental processes; physiology; Stress; psychological; physiopathology ID MENTAL STRESS; AEROBIC EXERCISE; PLASMA; CHALLENGE; INTENSITY; INCREASES; BLOOD AB The purpose of this study was to examine the cardiorespiratory (CR) and stress hormone responses to a combined physical and mental stress. Eight participants with participants responding to a computerized mental challenge dual stress condition (DSC) and a control condition of the same duration and intensity without the mental challenge exercise alone condition (EAC). Significant interactions across time were found for CR responses, with heart rate, ventilation, and respiration rate demonstrating higher increases in the DSC. Additionally, norepinephrine was significantly greater in the DSC at the end of the combined challenge. Furthermore, cortisol area-under-the-curve (AUC) was also significantly elevated during the DSC. These results demonstrate that a mental challenge during exercise can exacerbate the stress response, including the release of hormones that have been linked to negative health consequences (cardiovascular, metabolic, autoimmune illnesses). C1 [Webb, Heather E.] Mississippi State Univ, Dept Kinesiol, Mississippi State, MS 39762 USA. [Weldy, Michael L.; Fabianke-Kadue, Emily C.; Orndorff, G. R.] Univ Mississippi, Dept Hlth Exercise Sci & Recreat Management, Oxford, MS USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Acevedo, Edmund O.] Virginia Commonwealth Univ, Dept Hlth & Human Performance, Richmond, VA USA. RP Webb, HE (reprint author), Mississippi State Univ, Dept Kinesiol, 121 McCarthy Gymnasium, Mississippi State, MS 39762 USA. EM hwebb@colled.msstate.edu RI Webb, Heather/A-4219-2010 OI Webb, Heather/0000-0002-3925-9613 NR 33 TC 19 Z9 19 U1 3 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD DEC PY 2008 VL 104 IS 6 BP 973 EP 981 DI 10.1007/s00421-008-0852-1 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 368QB UT WOS:000260636500004 PM 18762969 ER PT J AU Kenefick, RW St Pierre, A Riel, NA Cheuvront, SN Castellani, JW AF Kenefick, Robert William St Pierre, A. Riel, N. A. Cheuvront, S. N. Castellani, J. W. TI Effect of increased plasma osmolality on cold-induced thirst attenuation SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Dehydration; Thirst; NaCl load; Cold exposure ID VASOPRESSIN RELEASE; OSMOTIC THIRST; DEHYDRATION; EXERCISE; HYPOHYDRATION; DRINKING; HUMANS; THERMOREGULATION; TEMPERATURE; STIMULATION AB The effects of elevating plasma osmolality (P (osm)) on thirst ratings was studied in eight dehydrated males during exposure to 4C. On two occasions, subjects were dehydrated (DH; 3-4% body mass) via 90 min exercise-heat exposure and overnight fluid restriction (day 1). On a third occasion, subjects were exposed to heat but were given fluid (EU). On day 2, subjects consumed NaCl (NaCl; 0.1 g NaCl kg-1 body mass in 500 ml H(2)O; DH only) or Placebo (P; 500 ml H(2)O; DH and EU). Subjects stood for 30 min at 24C and for 45 min at 4C (75 min post-dose). P (osm) was elevated (P < 0.05) 30 and 75 min after NaCl administration in DH + NaCl versus DH + P and EU + P treatments. Thirst ratings remained elevated (P < 0.05) in the DH + NaCl treatment 30 min after dosing and 45 min at 4C versus DH + P and EU + P. Attenuation of thirst when dehydrated in the cold can be over-ridden by increasing P (osm). C1 [Kenefick, Robert William; Cheuvront, S. N.; Castellani, J. W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [St Pierre, A.; Riel, N. A.] Univ New Hampshire, Dept Kinesiol, Durham, NH 03824 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Robert.Kenefick@us.army.mil OI van Riel, Natal/0000-0001-9375-4730 NR 27 TC 2 Z9 2 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD DEC PY 2008 VL 104 IS 6 BP 1013 EP 1019 DI 10.1007/s00421-008-0857-9 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 368QB UT WOS:000260636500009 PM 18758804 ER PT J AU Kunz, AN Englund, JA Kuypers, J Maranich, A Fairchok, MP AF Kunz, A. N. Englund, J. A. Kuypers, J. Maranich, A. Fairchok, M. P. TI Detection of multiple respiratory viruses by real-time polymerase chain reaction in infants attending an outpatient clinic SO EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES LA English DT Editorial Material ID YOUNG-CHILDREN; TRACT DISEASE; PCR ASSAYS; CORONAVIRUS C1 [Kunz, A. N.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Kuypers, J.] Univ Washington, Dept Lab Med, Seattle, WA 98105 USA. [Englund, J. A.; Fairchok, M. P.] Univ Washington, Childrens Hosp & Reg Med Ctr, Seattle, WA 98105 USA. [Kunz, A. N.; Maranich, A.; Fairchok, M. P.] Madigan Army Med Ctr, Dept Pediat, Tacoma, WA 98431 USA. RP Kunz, AN (reprint author), Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. EM kdocs2002@verizon.net NR 9 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0934-9723 J9 EUR J CLIN MICROBIOL JI Eur. J. Clin. Microbiol. Infect. Dis. PD DEC PY 2008 VL 27 IS 12 BP 1245 EP 1248 DI 10.1007/s10096-008-0558-7 PG 4 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 373EB UT WOS:000260952700014 PM 18560910 ER PT J AU Blakely, JN Corron, J AF Blakely, J. N. Corron, J. TI Time shifting chaotic signals using synchronization SO EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS LA English DT Article; Proceedings Paper CT Conference on Chaos and Nonlinear Dynamics CY 2007 CL Univ Aberdeen, Aberdeen, SCOTLAND HO Univ Aberdeen ID LAG SYNCHRONIZATION; OSCILLATOR ARRAYS; PHASE AB In this paper we examine couplings that produce time-shifted synchronization. We find a surprising variety of time-shifted states can be attained without including an explicit time-delay term in the coupling. We characterize the observed synchronization by determining the dependence of the time shift and cross correlation between the drive and response oscillators on a tunable parameter. Our observations agree well with a recently introduced method for estimating the time shift and cross correlation using a transfer function. C1 [Blakely, J. N.; Corron, J.] USA, RDECOM, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. RP Blakely, JN (reprint author), USA, RDECOM, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. EM jonathan.blakely@us.army.mil; ned.corron@us.army.mil OI Blakely, Jonathan/0000-0002-9772-582X; Corron, Ned/0000-0002-3232-5024 NR 13 TC 2 Z9 2 U1 0 U2 0 PU EDP SCIENCES S A PI LES ULIS CEDEX A PA 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE SN 1951-6355 J9 EUR PHYS J-SPEC TOP JI Eur. Phys. J.-Spec. Top. PD DEC PY 2008 VL 165 BP 111 EP 117 DI 10.1140/epjst/e2008-00854-0 PG 7 WC Physics, Multidisciplinary SC Physics GA 383UC UT WOS:000261698100012 ER PT J AU Oudkerk, M Stillman, AE Halliburton, SS Kalender, WA Mohlenkamp, S McCollough, CH Vliegenthart, R Shaw, LJ Stanford, W Taylor, AJ van Ooijen, PMA Wexler, L Raggi, P AF Oudkerk, Matthijs Stillman, Arthur E. Halliburton, Sandra S. Kalender, Willi A. Moehlenkamp, Stefan McCollough, Cynthia H. Vliegenthart, Rozemarijn Shaw, Leslee J. Stanford, William Taylor, Allen J. van Ooijen, Peter M. A. Wexler, Lewis Raggi, Paolo TI Coronary artery calcium screening: current status and recommendations from the European Society of Cardiac Radiology and North American Society for Cardiovascular Imaging SO EUROPEAN RADIOLOGY LA English DT Review DE Coronary artery calcium; Coronary artery atherosclerosis; Coronary risk assessment; Coronary artery CT ID BEAM COMPUTED-TOMOGRAPHY; ALL-CAUSE MORTALITY; HEART-DISEASE EVENTS; STAGE RENAL-DISEASE; ACUTE MYOCARDIAL-INFARCTION; EXPERT CONSENSUS DOCUMENT; LIPID-LOWERING THERAPY; ACUTE CHEST-PAIN; RISK-FACTORS; PROGNOSTIC VALUE AB Current guidelines and literature on screening for coronary artery calcium for cardiac risk assessment are reviewed for both general and special populations. It is shown that for both general and special populations a zero score excludes most clinically relevant coronary artery disease. The importance of standardization of coronary artery calcium measurements by multidetector CT is discussed. C1 [Oudkerk, Matthijs; Vliegenthart, Rozemarijn; van Ooijen, Peter M. A.] Univ Groningen Hosp, Dept Radiol, NL-9700 RB Groningen, Netherlands. [Stillman, Arthur E.; Shaw, Leslee J.; Raggi, Paolo] Emory Univ, Dept Radiol, Atlanta, GA 30322 USA. [Stillman, Arthur E.; Shaw, Leslee J.; Raggi, Paolo] Emory Univ, Dept Cardiol, Atlanta, GA 30322 USA. [Halliburton, Sandra S.] Cleveland Clin Fdn, Imaging Inst, Cardiovasc Imaging Lab, Cleveland, OH 44195 USA. [Kalender, Willi A.] Univ Erlangen Nurnberg, Inst Med Phys, Nurnberg, Germany. [Moehlenkamp, Stefan] Univ Duisburg Essen, W German Heart Ctr Essen, Essen, Germany. [McCollough, Cynthia H.] Mayo Clin, Dept Radiol, Rochester, MN USA. [Stanford, William] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA. [Taylor, Allen J.] Walter Reed Army Med Ctr, Div Cardiol, Washington, DC 20307 USA. [Wexler, Lewis] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA. RP van Ooijen, PMA (reprint author), Univ Groningen Hosp, Dept Radiol, Hanzepl 1, NL-9700 RB Groningen, Netherlands. EM p.m.a.van.ooyen@rad.azg.nl RI van Ooijen, Peter/G-1146-2012; van Ooijen, Peter/B-9150-2008 OI van Ooijen, Peter/0000-0002-8995-1210; van Ooijen, Peter/0000-0002-8995-1210 NR 142 TC 56 Z9 57 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0938-7994 J9 EUR RADIOL JI Eur. Radiol. PD DEC PY 2008 VL 18 IS 12 BP 2785 EP 2807 DI 10.1007/s00330-008-1095-6 PG 23 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 371NF UT WOS:000260837300012 PM 18651153 ER PT J AU Jeka, JJ Oie, KS Kiemel, T AF Jeka, John J. Oie, Kelvin S. Kiemel, Tim TI Asymmetric adaptation with functional advantage in human sensorimotor control SO EXPERIMENTAL BRAIN RESEARCH LA English DT Article DE Sensory re-weighting; Multisensory fusion; Vision; Adaptive control; Posture ID HUMAN POSTURAL CONTROL; MULTISENSORY INTEGRATION; SENSORY INTEGRATION; VISUAL ENVIRONMENT; SWAY; INFORMATION; DYNAMICS; VISION; STANCE; ADULTS AB Human movement control is inherently stochastic, requiring continuous estimation of self-motion based upon noisy sensory inputs. The nervous system must determine which sensory signals are relevant on a time scale that enables successful behavior. In human stance control, failure to effectively adapt to changing sensory contexts could lead to injurious falls. Nonlinear changes in postural sway amplitude in response to changes in sensory environmental motion have indicated a dynamic changing of the weighting of the nervous system's multiple sensory inputs so that estimates are based upon the most relevant and accurate information available. However, the time scale of these changes is virtually unknown. Results here show systematic changes in postural gain when visual scene motion amplitude is increased or decreased abruptly, consistent with sensory re-weighting. However, this re-weighting displayed a temporal asymmetry. When visual motion increased, gain decreased within 5 s to a value near its asymptotic value. In contrast, when visual motion decreased, it took an additional 5 s for gain to increase by a similar absolute amount. Suddenly increasing visual motion amplitude threatens balance if gain remains high, and rapid down-weighting of the sensory signal is required to avoid falling. By contrast, slow up-weighting suggests a conservative CNS strategy. It may not be functional to rapidly up-weight with transient changes in the sensory environment. Only sustained changes necessitate the slower up-weighting process. Such results add to our understanding of adaptive processing, identifying a temporal asymmetry in sensory re-weighting dynamics that could be a general property of adaptive estimation in the nervous system. C1 [Jeka, John J.; Oie, Kelvin S.; Kiemel, Tim] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA. [Jeka, John J.; Oie, Kelvin S.] Univ Maryland, Neurosci & Cognit Sci Program, College Pk, MD 20742 USA. [Jeka, John J.] Univ Maryland, Bioengn Grad Program, College Pk, MD 20742 USA. [Oie, Kelvin S.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Jeka, JJ (reprint author), Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA. EM jjeka@umd.edu FU National Institutes of Health [NIH 2RO1NS35070, 1RO1NS046065] FX We would like to thank Dr. Jose Barela at the Universidade Estadual Paulista in Rio Claro, Brazil for fruitful discussions of data on reweighting dynamics acquired in his laboratory. Kelvin S Oie is currently with the U. S. Army Research Laboratory, Human Research and Engineering Directorate, Aberdeen Proving Ground, MD 21005. These results were presented in preliminary form at the 17th meeting of the International Society of Posture and Gait, Marseille, France ( Oie et al. 2005). Funding for this research was provided by National Institutes of Health grants NIH 2RO1NS35070 and 1RO1NS046065, John J. Jeka, P. I. NR 42 TC 26 Z9 27 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4819 J9 EXP BRAIN RES JI Exp. Brain Res. PD DEC PY 2008 VL 191 IS 4 BP 453 EP 463 DI 10.1007/s00221-008-1539-x PG 11 WC Neurosciences SC Neurosciences & Neurology GA 366GV UT WOS:000260469600006 PM 18719898 ER PT J AU Mallozzi, M Bozue, J Giorno, R Moody, KS Slack, A Cote, C Qiu, DL Wang, R McKenney, P Lai, EM Maddock, JR Friedlander, A Welkos, S Eichenberger, P Driks, A AF Mallozzi, Michael Bozue, Joel Giorno, Rebecca Moody, Krishna-Sulayman Slack, Alex Cote, Christopher Qiu, Dengli Wang, Rong McKenney, Peter Lai, Erh-Min Maddock, Janine R. Friedlander, Arthur Welkos, Susan Eichenberger, Patrick Driks, Adam TI Characterization of a Bacillus anthracis spore coat-surface protein that influences coat-surface morphology SO FEMS MICROBIOLOGY LETTERS LA English DT Article DE Bacillus anthracis; coat; germination; spore assembly; anthrax ID STRUCTURAL DYNAMICS; BACTERIAL-SPORES; SUBTILIS SPORES; GENE-EXPRESSION; MORPHOGENESIS; SPORULATION; RESISTANCE; VIRULENCE; COTE AB Bacterial spores are encased in a multilayered proteinaceous shell, called the coat. In many Bacillus spp., the coat protects against environmental assault and facilitates germination. In Bacillus anthracis, the spore is the etiological agent of anthrax, and the functions of the coat likely contribute to virulence. Here, we characterize a B. anthracis spore protein, called Cot beta, which is encoded only in the genomes of the Bacillus cereus group. We found that Cot beta is synthesized specifically during sporulation and is assembled onto the spore coat surface. Our analysis of a cot beta null mutant in the Sterne strain reveals that Cot beta has a role in determining coat-surface morphology but does not detectably affect germination. In the fully virulent Ames strain, a cot beta null mutation has no effect on virulence in a murine model of B. anthracis infection. C1 [Mallozzi, Michael; Giorno, Rebecca; Slack, Alex; Driks, Adam] Loyola Univ, Med Ctr, Dept Microbiol & Immunol, Maywood, IL 60153 USA. [Bozue, Joel; Moody, Krishna-Sulayman; Cote, Christopher; Welkos, Susan] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. [Qiu, Dengli; Wang, Rong] IIT, Dept Biol Chem & Phys Sci, Chicago, IL 60616 USA. [McKenney, Peter; Eichenberger, Patrick] NYU, Dept Biol, New York, NY 10003 USA. [McKenney, Peter; Eichenberger, Patrick] NYU, Ctr Genom & Syst Biol, New York, NY 10003 USA. [Lai, Erh-Min] Acad Sinica, Inst Plant & Microbial Biol, Taipei 115, Taiwan. [Maddock, Janine R.] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI USA. [Friedlander, Arthur] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Driks, A (reprint author), Loyola Univ, Med Ctr, Dept Microbiol & Immunol, 2160 S 1st Ave,Bldg 105,Rm 3820, Maywood, IL 60153 USA. EM adriks@lumc.edu FU National Institutes of Health (NIH) [GM53989, AI53365]; Department of the Army [W81XWH-0401-0307]; United States Army Medical Research and Materiel Command [02-4-5C018, 02-4-5C-023, 04-0-IL-002] FX This work was supported by grants GM53989 and AI53365 from the National Institutes of Health (NIH) (A. D.), Department of the Army Award Number W81XWH-0401-0307 (P.E.), and the United States Army Medical Research and Materiel Command under Projects 02-4-5C018 (J.A.B.), 02-4-5C-023 (S.W.) and 04-0-IL-002 (S.W.). Research was onducted in compliance with the Animal Welfare Act, and other federal statutes and regulations relating to animals and experiments involving animals, and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the United States Army. We thank the Michigan Proteome Consortium for the identification of Cotb. NR 42 TC 11 Z9 11 U1 0 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0378-1097 J9 FEMS MICROBIOL LETT JI FEMS Microbiol. Lett. PD DEC PY 2008 VL 289 IS 1 BP 110 EP 117 DI 10.1111/j.1574-6968.2008.01380.x PG 8 WC Microbiology SC Microbiology GA 362GJ UT WOS:000260185900016 PM 19054101 ER PT J AU Levens, ED Whitcom, BW Hennessy, S James, AN Yauger, BJ Larsen, FW AF Levens, Eric D. Whitcom, Brian W. Hennessy, Sasha James, Aidita N. Yauger, Belinda J. Larsen, Frederick W. TI Blastocyst development rate impacts outcome in cryopreserved blastocyst transfer cycles SO FERTILITY AND STERILITY LA English DT Article DE Frozen-thawed blastocyst cycle; embryo transfer; day 5 versus day 6 ID IN-VITRO FERTILIZATION; EMBRYO-TRANSFER; PREGNANCY RATES; CULTURE; DAY-5; SUCCESS; IMPLANTATION; NUMBER AB Objective: To assess cycle outcome among day 5 and day 6 cryopreserved frozen-thawed blastocyst embryo transfers (FBET). Design: Retrospective cohort study. Setting: Military-based assisted reproduction technology (ART) center. Patient(s): One hundred seventy-two nondonor, programmed cryopreserved embryo cycles. Intervention(s): Fully expanded blastocysts on day 5 were cryopreserved on day 5, and those achieving this state on day 6 were cryopreserved on day 6. Leuprolide acetate was given for ovulation inhibition, and endometrial supplementation was by oral and vaginal estradiol. Progesterone in oil was administered, and blastocyst transfer occurred in the morning of the sixth day of progesterone. Main Outcome Measure(s): Implantation, pregnancy, and live-birth rates. Result(s): Fresh and frozen cycle characteristics were similar between groups. Day-5 FBET had statistically significantly higher implantation rates (32.2% vs. 19.2%), which remained significant even when adjusting for covariates (odds ratio: 1.91; 95% confidence interval, 1.00, 3.67). Live-birth rates trended toward improvement after adjusting for covariates (odds ratio: 1.18; 95% confidence interval, 0.61, 2.30). Conclusion(s): Cryopreserved day-5 blastocysts have higher implantation rates and trend toward improved pregnancy outcomes compared with cryopreserved day-6 blastocysts. This suggests that embryo development rate may, in part, predict implantation and subsequent FBET outcomes, although embryos not achieving the blastocyst stage until day 6 still demonstrate acceptable outcomes. (Fertil Steril(R) 2008;90:2138-43. (C) 2008 by American Society for Reproductive Medicine.) C1 [Levens, Eric D.; Yauger, Belinda J.] NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. [Whitcom, Brian W.] NICHHD, Epidemiol Branch, NIH, Bethesda, MD 20892 USA. [Levens, Eric D.; Yauger, Belinda J.; Larsen, Frederick W.] Walter Reed Army Med Ctr, ART Program, Washington, DC 20307 USA. [Levens, Eric D.; Yauger, Belinda J.; Larsen, Frederick W.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Levens, Eric D.; Yauger, Belinda J.; Larsen, Frederick W.] NIH, Combined Fed Fellowship Program Reprod Endocrinol, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20892 USA. [Hennessy, Sasha; James, Aidita N.] Wasington Inc, ART Inst, Washington, DC USA. RP Levens, ED (reprint author), NICHHD, Reprod Biol & Med Branch, NIH, Bldg 10,CRC,Room E1-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM levense@mail.nih.gov FU Reproductive Biology and Medicine Branch, NICHD, NIH, Bethesda, MD FX Research supported, in part, by the Reproductive Biology and Medicine Branch, NICHD, NIH, Bethesda, MD. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of Health and Human Services, the Department of the Army or the Department of Defense. NR 19 TC 18 Z9 18 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD DEC PY 2008 VL 90 IS 6 BP 2138 EP 2143 DI 10.1016/j.fertnstert.2007.10.029 PG 6 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 381WO UT WOS:000261566800015 PM 18178191 ER PT J AU Sun, WJ Stegmann, BJ Henne, M Cwherino, WH Segars, JH AF Sun, Wenjie Stegmann, Barbara J. Henne, Melinda Cwherino, Williain H. Segars, James H. TI A new approach to ovarian reserve testing SO FERTILITY AND STERILITY LA English DT Article DE Ovarian reserve; ovarian insufficiency; FSH; CC challenge test; inhibin; diminished ovarian reserve; assisted reproduction; in vitro fertilization (IVF); assisted reproductive technologies (ART) ID IN-VITRO FERTILIZATION; FOLLICLE-STIMULATING-HORMONE; ASSISTED REPRODUCTIVE TECHNOLOGY; CITRATE CHALLENGE TEST; RECURRENT PREGNANCY LOSS; ANTI-MULLERIAN HORMONE; INHIBIN-B; PREDICTIVE-VALUE; DOWNS-SYNDROME; BASAL MARKERS AB Objective: To critically examine ovarian reserve testing before assisted reproduction. Design: A PUBMED computer search to identify relevant literature. Setting: Multiple sites. Patient(s): Patients undergoing assisted reproduction. Intervention(S): Testing for ovarian reserve. Main Outcome Measure(S): Assisted reproductive technology (ART) and pregnancy outcomes. Result(S): The prevalence of ovarian insufficiency varies significantly for women aged 30-45 years. Gerieralization or averaging of threshold values across different aged women leads to very poor sensitivity, specificity, and positive predictive value for all tests of ovarian reserve. Because of the changing prevalence of ovarian insufficiency, there is no single, suitable threshold value for any screening test of ovarian reserve. Our analysis supports dividing impaired ovarian reserve into two groups: age-dependent ovarian aging (physiologic) and premature (non-physiologic) reductions in the oocyte pool. Interpretation of any screening test used requires that age is considered as a variable. To guide clinical interpretation of test results, We suggest using a nomogram of FSH values versus expected delivery rate-per-cycle-start with ART for a given age. Conclusion(s): Proper interpretation of screening tests for ovarian insufficiency in couples considering ART is important as the presence of impaired ovarian reserve is associated with a low likelihood of pregnancy. The condition of premature (nonphysiologic) ovarian insufficiency warrants additional research. (Fertil Steril(R) 2008;90:2196202. (C)2008 by American Society for Reproductive Medicine.) C1 [Stegmann, Barbara J.; Segars, James H.] NICHHD, Reprod Biol & Med Branch, Bethesda, MD 20892 USA. [Sun, Wenjie] Wake Forest Univ, Baptist Med Ctr, Dept Obstet & Gynecol, Winston Salem, NC 27109 USA. [Stegmann, Barbara J.; Henne, Melinda; Cwherino, Williain H.; Segars, James H.] Walter Reed Army Med Ctr, Walter Reed ART Program, Washington, DC 20307 USA. [Cwherino, Williain H.; Segars, James H.] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. RP Segars, JH (reprint author), NICHD, RBMB, NIH, Bldg 10,CRC,Room 1E-3140,MSC 1109,10 Ctr Dr, Bethesda, MD 20892 USA. EM segarsj@mail.nih.gov FU Reproductive Biology and Medicine Branch of National Institute of Child Health and Human Development, National Institutes of Health FX Supported, in part, by the Reproductive Biology and Medicine Branch of National Institute of Child Health and Human Development, National Institutes of Health. NR 44 TC 23 Z9 28 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD DEC PY 2008 VL 90 IS 6 BP 2196 EP 2202 DI 10.1016/j.fertnstert.2007.10.080 PG 7 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 381WO UT WOS:000261566800023 PM 18433750 ER PT J AU Hamilton, CA Maxwell, GL Chemofsky, MR Bernstein, SA Farley, JH Rose, GS AF Hamilton, Chad A. Maxwell, G. Larry Chemofsky, Mildred R. Bernstein, Sarah A. Farley, John H. Rose, G. Scott TI Intraperitoneal bevacizumab for the palliation of malignant ascites in refractory ovarian cancer SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Bevacizumab; Intraperitoneal; Ovarian cancer; Ascites; Palliation ID ENDOTHELIAL GROWTH-FACTOR; PHASE-II; TUMOR BURDEN; MODEL; IMMUNONEUTRALIZATION; THERAPY; TRIAL AB Background. Malignant ascites often has a profound impact on the quality of life of patients with refractory ovarian cancer. Current treatments, including dietary, medical, and procedural are often temporary and unsatisfactory options in patients approaching the end of life. Case. We present a case of an 88 year-old receiving home hospice care with refractory ovarian cancer and severe symptomatic ascites. We performed a paracentesis and treated her with intraperitoneal bevacizumab with dramatic improvement in her ascites and the quality of her final weeks of life. Conclusion. Intraperitoneal bevacizumab may be a useful 1001 in the palliation of malignant ascites and is worthy of further study. Published by Elsevier Inc. C1 [Hamilton, Chad A.; Maxwell, G. Larry; Chemofsky, Mildred R.; Bernstein, Sarah A.; Farley, John H.; Rose, G. Scott] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. RP Hamilton, CA (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM chad.hamilton@comcast.net NR 15 TC 48 Z9 50 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD DEC PY 2008 VL 111 IS 3 BP 530 EP 532 DI 10.1016/j.ygyno.2008.04.028 PG 3 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 384PZ UT WOS:000261758000026 PM 18561992 ER PT J AU Jones, JE Muza, SR Fulco, CS Beidleman, BA Tapia, ML Cymerman, A AF Jones, Juli E. Muza, Stephen R. Fulco, Charles S. Beidleman, Beth A. Tapia, Michael L. Cymerman, Allen TI Intermittent Hypoxic Exposure Does Not Improve Sleep at 4300 m SO HIGH ALTITUDE MEDICINE & BIOLOGY LA English DT Article DE sleep; altitude; altitude acclimatization; arterial oxygen saturation; desaturation ID ACUTE MOUNTAIN-SICKNESS; HIGH-ALTITUDE; WAKE IDENTIFICATION; ACCLIMATIZATION; PERFORMANCE; ACTIGRAPHY AB Jones, Juli E., Stephen R. Muza, Charles S. Fulco, Beth A. Beidleman, Michael L. Tapia, and Allen Cyerman. Intermittent hypoxic exposure does not improve sleep at 4300 m. High Alt. Med. Biol. 9: 281-288, 2008.-The purpose of this study was to determine in sea-level residents if 6 to 7 consecutive days of normobaric intermittent hypoxic exposure (IHE) (hypoxia room: 2-h ambient PO(2) = 90 mmHg sedentary and 1-h ambient PO(2) = 110 mmHg exercising at 80 +/- 5% of maximum heart rate) improved sleep quality (awakenings per hour) and quantity at altitude (4300 m). We hypothesized that IHE would improve sleep arterial oxygen saturation (SaO(2)) levels and decrease desaturation events, thereby contributing to improvements in sleep quality and quantity during subsequent exposure to high altitude. Ten sea-level residents (mean +/- SE: 22 +/- 1 yr, 179 +/- 2 cm, 79 +/- 3 kg) were assigned to an IHE group and six to a SHAM group (20 +/- 0.5 yr, 180 +/- 3 cm, 77 +/- 4 kg). Sleep quantity, SaO2, and heart rate ( HR) were monitored at sea level and during high altitude (i.e., 4300 m in a hypobaric chamber) before pretest ( PRE-T) and 60 h after posttest (POST-T) for the last IHE or SHAM treatment. Over the 6 to 7 days of IHE, resting SaO(2) increased from 75 +/- 1% to 81 +/- 3% in the IHE group, while the SHAM group remained at 98 +/- 1%. From PRE- T to POST-T at 4300-m exposure, both the IHE and SHAM groups had significantly higher sleep SaO(2), fewer desaturation events per hour, and an increase in the percentage of time asleep while sleeping (sleep percent). The IHE group, but not the SHAM group, had significantly lower sleep HR and a trend to more awakenings during the POST-T 4300-m exposure. These results indicate that although IHE treatment induced significant ventilatory acclimatization, relative to the SHAM group, IHE did not further improve sleep SaO(2) quality and quantity following rapid ascent to 4300 m. Rather, it is likely that the acquired ventilatory acclimatization was lost in the 60 h between the last IHE session and the POST-T altitude exposure. C1 [Jones, Juli E.; Muza, Stephen R.; Fulco, Charles S.; Beidleman, Beth A.; Tapia, Michael L.; Cymerman, Allen] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Muza, SR (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM stephen.muza@us.army.mil FU Army Medical Research and Materiel Command [ATO IV.MD.2006.01] FX Funding was provided by U. S. Army Medical Research and Materiel Command ATO IV.MD.2006.01. NR 28 TC 6 Z9 6 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1527-0297 J9 HIGH ALT MED BIOL JI High Alt. Med. Biol. PD DEC PY 2008 VL 9 IS 4 BP 281 EP 287 DI 10.1089/ham.2008.1039 PG 7 WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences GA 389IG UT WOS:000262085500004 PM 19115911 ER PT J AU Salas, E DiazGranados, D Klein, C Burke, CS Stagl, KC Goodwin, GF Halpin, SM AF Salas, Eduardo DiazGranados, Deborah Klein, Cameron Burke, C. Shawn Stagl, Kevin C. Goodwin, Gerald F. Halpin, Stanley M. TI Does Team Training Improve Team Performance? A Meta-Analysis SO HUMAN FACTORS LA English DT Review ID CORRELATION-COEFFICIENTS; DECISION-MAKING; WORK; IMPACT; PROGRAM; MODEL; INTERDEPENDENCE; ORGANIZATIONS; INTEGRATION; LEADERSHIP AB Objective: This research effort leveraged the science of training to guide a taxonomic integration and a series of meta-analyses to gauge the effectiveness and boundary conditions of team training interventions for enhancing team outcomes. Background: Disparate effect sizes across primary studies have made it difficult to determine the true strength of the relationships between team training techniques and team Outcomes. Method: Several meta-analytic integrations were conducted to examine the relationships between team training interventions and team functioning. Specifically, we assessed the relative effectiveness of these interventions on team cognitive, affective, process,and performance outcomes. Training content, team membership stability, and team size were investigated as potential moderators of the relationship between team training and outcomes. In total, the database consisted of 93 effect sizes representing 2,650 teams. Results: The results Suggested that moderate, positive relationships exist between team training interventions and each of the outcome types. The findings of moderator analyses indicated that training content, team membership stability, and team size moderate the effectiveness of these interventions. Conclusion: Our findings suggest that team training interventions are a viable approach organizations can take in order to enhance team outcomes. They are useful for improving cognitive Outcomes, affective outcomes, teamwork processes, and performance outcomes. Moreover, results suggest that training content, team membership stability, and team size moderate the effectiveness of team training interventions. Application: Applications of the results from this research are numerous. Those who design and administer training can benefit from these findings in order to improve the effectiveness of their team training interventions. C1 [Salas, Eduardo; DiazGranados, Deborah; Burke, C. Shawn] Univ Cent Florida, Inst Simulat & Training, Orlando, FL 32826 USA. [Salas, Eduardo; DiazGranados, Deborah; Klein, Cameron] Univ Cent Florida, Dept Psychol, Orlando, FL 32826 USA. [Stagl, Kevin C.] Talent Threshold LLC, Orlando, FL USA. [Goodwin, Gerald F.] Army Res Inst, Basic Res Unit, Arlington, VA USA. [Halpin, Stanley M.] Army Res Inst, Leader Dev Unit, Ft Leavenworth Res Unit, Ft Leavenworth, KS USA. RP Salas, E (reprint author), Univ Cent Florida, Inst Simulat & Training, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM esalas@ist.ucf.edu FU U.S. Army Research Institute for the Behavioral and Social Sciences [W74V8H-04-C0025] FX This work was supported by funding from the U.S. Army Research Institute for the Behavioral and Social Sciences (Contract W74V8H-04-C0025). The views, opinions, and/or findings contained in this paper are those of the authors and should not be construed as an official position, policy, or decision of the Department of the Army or the University of Central Florida.; We would like to thank Huy Le, John Mathieu, and Florian Jentsch for their insightful guidance during the course of this project. We would also like to acknowledge Shannon Scielzo and Samuel Wooten for their assistance during the early coding portions of the project. NR 157 TC 155 Z9 157 U1 14 U2 90 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD DEC PY 2008 VL 50 IS 6 BP 903 EP 933 DI 10.1518/001872008X375009 PG 31 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 410LB UT WOS:000263577400005 PM 19292013 ER PT J AU Veliadis, V Snook, M McNutt, T Hearne, H Potyraj, P Lelis, A Scozzie, C AF Veliadis, V. Snook, M. McNutt, T. Hearne, H. Potyraj, P. Lelis, Aivars Scozzie, C. TI A 2055-V (at 0.7 mA/cm(2)) 24-A (at 706 W/cm(2)) Normally On 4H-SiC JFET With 6.8-mm(2) Active Area and Blocking-Voltage Capability Reaching the Material Limit SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Edge termination; guard rings; high current; high power; high voltage; junction field-effect transistor (JFET); large area; normally on; vertical channel; 4H-SiC ID TEMPERATURE AB A normally on 4H-SiC vertical-junction field-effect transistor (VJFET) of 6.8-mm(2) active area was manufactured in seven photolithographic levels with no epitaxial regrowth and a single masked ion-implantation event. The VJFET exhibits low leakage currents with very sharp onsets of voltage breakdowns. At a forward gate bias of 2.5 V, the VJFET outputs 24 A (353 A/cm(2)) at a forward drain-voltage drop of 2 V (706 W/cm(2)), with a current gain of I-D/I-G = 21818, and a specific ON-state resistance of 5.7 m Omega center dot cm(2). Self-aligned floating guard rings provide edge termination that blocks 2055 V at a gate bias of -37 V and a drain-current density of 0.7 mA/cm(2). This blocking voltage corresponds to 94.4% of the VJFET's 11.7-mu m/3.46 x 10(15)-cm(3) SiC drift layer limit and is the highest reported blocking-voltage efficiency of any SiC power device under similar drain-current-density conditions. C1 [Veliadis, V.; Snook, M.; McNutt, T.; Hearne, H.; Potyraj, P.] Northrop Grumman Adv Technol Lab, Linthicum, MD 21090 USA. [Lelis, Aivars; Scozzie, C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Adv Technol Lab, Linthicum, MD 21090 USA. FU U.S. Army Research Laboratory [W91INF-06-2-0002] FX This work was supported by the U.S. Army Research Laboratory under Cooperative Agreement W91INF-06-2-0002. The review of this letter was arranged by Editor S.-H. Ryu. NR 12 TC 26 Z9 30 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD DEC PY 2008 VL 29 IS 12 BP 1325 EP 1327 DI 10.1109/LED.2008.2006766 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 389AL UT WOS:000262062000012 ER PT J AU Masrur, MA AF Masrur, M. Abul TI Penalty for Fuel Economy-System Level Perspectives on the Reliability of Hybrid Electric Vehicles During Normal and Graceful Degradation Operation SO IEEE SYSTEMS JOURNAL LA English DT Article DE Controller area network (CAN) controller; graceful degradation; hybrid electric vehicle (HEV); inverter; motor; multiplex system; power electronics; reliability AB Generally people tend to think only in terms of fuel economy and additional cost premium on vehicle price while discussing about hybrid electric vehicles (HEV). This paper tries to emphasize that the overall acceptability of a vehicle also has to do with its system level reliability. It discusses the issue of system level reliability in hybrid electric vehicles from a quantitative point of view. It also introduces a quantitative meaning to the concept of graceful degradation and mode of operation under graceful degradation condition. All these are discussed in stages, starting from a regular internal combustion engine based vehicle, and later transition of those to hybrid electric vehicles. This paper intends to drive the point that in HEV, one of the penalties for fuel economy that has to be paid comes in terms of reliability. C1 USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Masrur, MA (reprint author), USA, RDECOM TARDEC, Warren, MI 48397 USA. EM md.abul.masrur@us.army.mil NR 7 TC 8 Z9 8 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1932-8184 J9 IEEE SYST J JI IEEE Syst. J. PD DEC PY 2008 VL 2 IS 4 BP 476 EP 483 DI 10.1109/JSYST.2008.2005714 PG 8 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Operations Research & Management Science; Telecommunications SC Computer Science; Engineering; Operations Research & Management Science; Telecommunications GA V10NF UT WOS:000207470000004 ER PT J AU Ho, J Jow, TR Boggs, SA AF Ho, Janet Jow, T. Richard Boggs, Steven A. TI Implications of Advanced Capacitor Dielectrics for Performance of Metallized Film Capacitor Windings SO IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION LA English DT Article; Proceedings Paper CT Volta Colloquium on Partial Discharge Measuements CY 2007 CL Como, ITALY DE Metallized film capacitors; pulsed discharge; ESL; ESR; dielectric constant; capacitor design ID ENERGY-STORAGE CAPACITORS AB A range of high dielectric capacitor films is under development with the objective of improving the energy density of pulsed discharge capacitors. A substantial change in capacitor film dielectric constant has implications for capacitor design and function. This paper develops formulas for equivalent series resistance (ESR) and equivalent series inductance (ESL) of a cylindrical capacitor winding as a function of material properties and winding design. A numerical approach is used to investigate the frequency-dependent ESR and ESL, after which formulas are developed for winding inductance based on a resistive current distribution in the winding. Analyses are carried out for a cylindrical metallized film winding in which the return conductor is brought either through the center of the core on which the film is wound or coaxially up the outside of the winding, so that both connections are made from the same end of the capacitor with minimal inductance. The implications of moving to high dielectric constant film are investigated on the basis of this analysis. C1 [Ho, Janet; Jow, T. Richard] USA, Res Lab, Adelphi, MD 20783 USA. [Boggs, Steven A.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06268 USA. [Boggs, Steven A.] Univ Connecticut, Dept Elect Engn, Storrs, CT 06268 USA. [Boggs, Steven A.] Univ Connecticut, Dept Phys, Storrs, CT 06268 USA. RP Ho, J (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 4 TC 9 Z9 9 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1070-9878 J9 IEEE T DIELECT EL IN JI IEEE Trns. Dielectr. Electr. Insul. PD DEC PY 2008 VL 15 IS 6 BP 1754 EP 1760 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 378GI UT WOS:000261308800034 ER PT J AU Toonen, RC Haselby, CC Blick, RH AF Toonen, Ryan Christopher Haselby, Cyrus C. Blick, Robert H. TI An Ultrawideband Cross-Correlation Radiometer for Mesoscopic Experiments SO IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT LA English DT Article DE Correlation; correlators; microwave radiometry; noise; noise measurement; quantum-effect semiconductor devices; radiometry; temperature measurement ID HANBURY-BROWN AB We have designed, built, and tested a cross-correlation radiometer for detecting quantum statistical fluctuations in mesoscopic experiments. We present the details of our design and the results of our characterization. Our instrument operates over the X- and Ku-bands (8-18 GHz). Digital signal processing techniques are used to provide robustness against instrumentation drifts and offsets. The economized version of our instrument can detect, with sufficient correlation efficiency, noise signals having power levels as low as 10 fW. The modularity of our design allows one to easily alter the specifications (such as the bandwidth and the sensitivity) by simply replacing individual components. Index Terms-Correlation, correlators, microwave radiometry, noise, noise measurement, quantum-effect semiconductor devices, radiometry, temperature measurement. C1 [Toonen, Ryan Christopher] Natl Inst Stand & Technol, Boulder, CO 80305 USA. [Haselby, Cyrus C.] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA. [Blick, Robert H.] Univ Wisconsin, Madison, WI 53706 USA. RP Toonen, RC (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 22 TC 1 Z9 1 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9456 EI 1557-9662 J9 IEEE T INSTRUM MEAS JI IEEE Trans. Instrum. Meas. PD DEC PY 2008 VL 57 IS 12 BP 2874 EP 2879 DI 10.1109/TIM.2008.925011 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 373YF UT WOS:000261008700023 ER PT J AU Darwish, AM Bayba, AJ Hung, HA AF Darwish, Ali M. Bayba, Andrew J. Hung, H. Alfred TI Utilizing Diode Characteristics for GaN HEMT Channel Temperature Prediction SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE Channel temperature; field-effect transistor (FET); GaN; high-electron mobility transistor (HEMT); reliability; thermal resistance ID FIELD-EFFECT TRANSISTORS; THERMAL-RESISTANCE; RAMAN-SPECTROSCOPY; PERFORMANCE; DEVICES AB Measuring channel temperature in GaN high-electron mobility transistors (HEMTs) is challenging due to the submicrometer dimensions of the gate fingers. The HEMT characteristics are electrically and thermally dependent. The channel temperature is measured using the Schottky gate-diode forward characteristics and compared with results of simulation, theory, and experimental evidence. The pulsed gate-diode forward resistance and threshold voltage predict channel temperatures that agree well with other methods. The technique presented provides a fast, easily implementable methodology for estimating channel temperature. C1 [Darwish, Ali M.; Bayba, Andrew J.; Hung, H. Alfred] USA, Res Lab, Adelphi, MD 20783 USA. RP Darwish, AM (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 20 TC 13 Z9 14 U1 0 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD DEC PY 2008 VL 56 IS 12 BP 3188 EP 3192 DI 10.1109/TMTT.2008.2007364 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA 386PS UT WOS:000261895700022 ER PT J AU Matveev, IB Serbin, SI Lux, SM AF Matveev, Igor B. Serbin, Serhiy I. Lux, Scott M. TI Efficiency of a Hybrid-Type Plasma-Assisted Fuel Reformation System SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Coal; combustion; liquid fuel; plasma; reformation; waste processing AB The major advantages of a new plasma-assisted fuel reformation system are its cost effectiveness and technical efficiency. Applied Plasma Technologies has proposed its new highly efficient hybrid-type plasma-assisted system for organic fuel combustion and gasification. The system operates as a multimode multipurpose reactor in a wide range of plasma feedstock gases and turndown ratios. This system also has convenient and simultaneous feeding of several reagents in the reaction zone such as liquid fuels, coal, steam, and air. A special methodology has been developed for such a system in terms of heat balance evaluation and optimization. This methodology considers all existing and possible energy streams, which could influence the system's efficiency . The developed hybrid-type plasma system could be suitable for combustion applications, mobile and autonomous small- to mid-size liquid fuel and coal gasification modules, hydrogen-rich gas generators, waste-processing facilities, and plasma chemical reactors. C1 [Matveev, Igor B.] Appl Plasma Technol, Mclean, VA 22101 USA. [Serbin, Serhiy I.] Natl Univ Shipbldg, Turbine Units Dept, UA-54025 Mykolayiv, Ukraine. [Lux, Scott M.] USA, Ctr Res Dev & Engn, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Matveev, IB (reprint author), Appl Plasma Technol, Mclean, VA 22101 USA. EM i.matveev@att.net; serhiy@serbin.mk.ua; Scott.M.Lux@usace.army.mil RI Serbin, Serhiy/E-9056-2016; OI Serbin, Serhiy/0000-0002-3423-2681 NR 17 TC 12 Z9 13 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD DEC PY 2008 VL 36 IS 6 BP 2940 EP 2946 DI 10.1109/TPS.2008.2006843 PG 7 WC Physics, Fluids & Plasmas SC Physics GA 389AK UT WOS:000262061900010 ER PT J AU Torrieri, D Valenti, MC AF Torrieri, Don Valenti, Matthew C. TI Constellation Labeling Maps for Low Error Floors SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article; Proceedings Paper CT IEEE Military Communications Conference (MILCOM 2007) CY OCT 29-31, 2007 CL Orlando, FL SP IEEE DE Constellation; labeling map; error floor; iterative decoding; bit-interleaved coded modulation ID INTERLEAVED CODED MODULATION; DESIGN; BICM AB A constellation labeling map is the assignment of a bit pattern to each symbol in a signal-set constellation. In a system with iterative decoding and demodulation, the error floor of the bit error rate is highly dependent on the labeling map. A simple class of labeling maps that significantly lower the error floors is presented. Examples show the applications of the proposed mapping to multiple phase-shift keying (MPSK), quadrature amplitude modulation (QAM), and continuous-phase frequency-shift keying (CPFSK). Simulation results indicate that the proposed labeling maps are comparable to or better than other labeling maps in providing a low error floor. A major advantage of the proposed labeling maps is that they are easily generated even when the alphabet size is large. C1 [Torrieri, Don] USA, Res Lab, Adelphi, MD 20783 USA. [Valenti, Matthew C.] W Virginia Univ, Morgantown, WV 26506 USA. RP Torrieri, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dtorr@arl.army.mil OI Valenti, Matthew/0000-0001-6089-0509 NR 12 TC 4 Z9 4 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD DEC PY 2008 VL 7 IS 12 BP 5401 EP 5407 DI 10.1109/T-WC.2008.071276 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 387AM UT WOS:000261924100035 ER PT J AU Mi, C Bai, H Wang, C Gargies, S AF Mi, C. Bai, H. Wang, C. Gargies, S. TI Operation, design and control of dual H-bridge-based isolated bidirectional DC DC converter SO IET POWER ELECTRONICS LA English DT Article AB The operation, design and control of an isolated bidirectional DC-DC converter for hybrid electric vehicle energy management applications are discussed. Different operation modes and boundary conditions are distinguished by phase-shift angle and load conditions. The absolute and relative output voltage ripple was derived. The dead-band effect and safe operational area are further investigated. The relations between output power and leakage inductance and switching frequency are also presented. The proposed converter was simulated and a prototype was built and tested. Experiments on the converter's steady state and transient operations validated the design and simulation. C1 [Mi, C.; Bai, H.] Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. [Wang, C.] NW Polytech Univ, Coll Marine Engn, Xian 710072, Shaanxi, Peoples R China. [Gargies, S.] USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Mi, C (reprint author), Univ Michigan, Dept Elect & Comp Engn, 4901 Evergreen Rd, Dearborn, MI 48128 USA. EM chrismi@umich.edu NR 21 TC 56 Z9 66 U1 1 U2 8 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1755-4535 J9 IET POWER ELECTRON JI IET Power Electron. PD DEC PY 2008 VL 1 IS 4 BP 507 EP 517 DI 10.1049/iet-pel:20080004 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA V11BW UT WOS:000207508100009 ER PT J AU Poly, F Read, TD Chen, YH Monteiro, MA Serichantalergs, O Pootong, P Bodhidatta, L Mason, CJ Rockabrand, D Baqar, S Porter, CK Tribble, D Darsley, M Guerry, P AF Poly, Frederic Read, Timothy D. Chen, Yu-Han Monteiro, Mario A. Serichantalergs, Oralak Pootong, Piyarat Bodhidatta, Ladaporn Mason, Carl J. Rockabrand, David Baqar, Shahida Porter, Chad K. Tribble, David Darsley, Michael Guerry, Patricia TI Characterization of Two Campylobacter jejuni Strains for Use in Volunteer Experimental-Infection Studies SO INFECTION AND IMMUNITY LA English DT Article ID GUILLAIN-BARRE-SYNDROME; MILLER-FISHER-SYNDROME; GENOME SEQUENCE; TETRACYCLINE RESISTANCE; PHASE VARIATION; LIPOOLIGOSACCHARIDE; BIOSYNTHESIS; CARBOHYDRATE; LIPOPOLYSACCHARIDES; IDENTIFICATION AB The development of vaccines against Campylobacter jejuni would be facilitated by the ability to perform phase II challenge studies. However, molecular mimicry of the lipooligosaccharide (LOS) of most C. jejuni strains with human gangliosides presents safety concerns about the development of Guillain-Barre syndrome. Clinical isolates of C. jejuni that appeared to lack genes for the synthesis of ganglioside mimics were identified by DNA probe analyses. Two clinical isolates from Southeast Asia (strains BH-01-0142 and CG8421) were determined to express the LOS type containing N-acetyl quinovosamine. No ganglioside structures were observed to be present in the LOSs of these strains, and pyrosequence analyses of the genomes of both strains confirmed the absence of genes involved in ganglioside mimicry. The capsule polysaccharide (CPS) of BH-01-0142 was determined to be composed of galactose (Gal), 6-deoxy-ido-heptose, and, in smaller amounts, D-glycero-D-ido-heptose, and the CPS of CG8421 was observed to contain Gal, 6-deoxy-altro-heptose, N-acetyl-glucosamine, and minor amounts of 6-deoxy-3-O-Me-altro-heptose. Both CPSs were shown to carry O-methyl-phosphoramidate. The two genomes contained strain-specific zones, some of which could be traced to a plasmid origin, and both contained a large chromosomal insertion related to the CJEI3 element of C. jejuni RM1221. The genomes of both strains shared a high degree of similarity to each other and, with the exception of the capsule locus of CG8421, to the type strain of the HS3 serotype, TGH9011. C1 [Guerry, Patricia] Naval Med Res Ctr, Enter Dis Dept, Silver Spring, MD 20910 USA. [Chen, Yu-Han; Monteiro, Mario A.] Univ Guelph, Guelph, ON N1G 2W1, Canada. [Serichantalergs, Oralak; Pootong, Piyarat; Bodhidatta, Ladaporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Tribble, David] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Darsley, Michael] ACE Biosci, Odense, Denmark. RP Guerry, P (reprint author), Naval Med Res Ctr, Enter Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM patricia.guerry@med.navy.mil RI Porter, Chad/A-8026-2011; Read, Timothy/E-6240-2011; Guerry, Patricia/A-8024-2011; OI MASON, CARL/0000-0002-3676-2811 FU Military Infectious Diseases Research Program Work Unit [6000.RAD1.DA3.A308]; NSERC; ACE Biosciences FX We thank Nicci Nolan, Shannon Lentz, Cheryl Ewing, Gary Majam, Julie Phan, and Lisa Applebee at the NMRC for their contributions to this study; Helen Tabor of the Canadian Microbiology Reference Laboratory in Winnipeg for Penner serotyping; and Michael Prouty for his comments on the manuscript.; Work at the NMRC was funded by the Military Infectious Diseases Research Program Work Unit 6000.RAD1.DA3.A308. M. A. M. was funded by the NSERC and ACE Biosciences.; The views expressed in this work are those of the authors and do not necessarily reflect the official policy or position of the Navy, the Department of Defense, or the U. S. government. NR 64 TC 28 Z9 28 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2008 VL 76 IS 12 BP 5655 EP 5667 DI 10.1128/IAI.00780-08 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 373WJ UT WOS:000261003900023 PM 18809665 ER PT J AU Caserta, JA Hale, ML Popoff, MR Stiles, BG McClane, BA AF Caserta, Justin A. Hale, Martha L. Popoff, Michel R. Stiles, Bradley G. McClane, Bruce A. TI Evidence that Membrane Rafts Are Not Required for the Action of Clostridium perfringens Enterotoxin SO INFECTION AND IMMUNITY LA English DT Article ID TIGHT-JUNCTION PROTEINS; CACO-2 CELLS; LIPID RAFTS; PORE FORMATION; ANTHRAX TOXIN; IOTA-TOXIN; CHOLESTEROL; MICRODOMAINS; OCCLUDIN; BINDING AB The action of bacterial pore-forming toxins typically involves membrane rafts for binding, oligomerization, and/or cytotoxicity. Clostridium perfringens enterotoxin (CPE) is a pore-forming toxin with a unique, multistep mechanism of action that involves the formation of complexes containing tight junction proteins that include claudins and, sometimes, occludin. Using sucrose density gradient centrifugation, this study evaluated whether the CPE complexes reside in membrane rafts and what role raft microdomains play in complex formation and CPE-induced cytotoxicity. Western blot analysis revealed that the small CPE complex and the CPE hexamer 1 (CH-1) complex, which is sufficient for CPE-induced cytotoxicity, both localize outside of rafts. The CH-2 complex was also found mainly in nonraft fractions, although a small pool of raft-associated CH-2 complex that was sensitive to cholesterol depletion with methyl-beta-cyclodextrin (M beta CD) was detected. Pretreatment of Caco-2 cells with M beta CD had no appreciable effect on CPE-induced cytotoxicity. Claudin-4 was localized to Triton X-100-soluble gradient fractions of control or CPE-treated Caco-2 cells, indicating a raft-independent association for this CPE receptor. In contrast, occludin was present in raft fractions of control Caco-2 cells. Treatment with either M beta CD or CPE caused most occludin molecules to shift out of lipid rafts, possibly due (at least in part) to the association of occludin with the CH-2 complex. Collectively, these results suggest that CPE is a unique pore-forming toxin for which membrane rafts are not required for binding, oligomerization/pore formation, or cytotoxicity. C1 [McClane, Bruce A.] Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, Pittsburgh, PA 15261 USA. [Caserta, Justin A.; McClane, Bruce A.] Univ Pittsburgh, Sch Med, Mol Virol & Microbiol Grad Program, Pittsburgh, PA 15261 USA. [Hale, Martha L.; Stiles, Bradley G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Popoff, Michel R.] Inst Pasteur, Unite Bacteries Anaerobies & Toxines, Paris, France. RP McClane, BA (reprint author), Univ Pittsburgh, Sch Med, Dept Microbiol & Mol Genet, E1240 BSTWR, Pittsburgh, PA 15261 USA. EM bamcc@pitt.edu FU National Institute of Allergy and Infectious Diseases [R37-AI019844-24, AI060525] FX This work was supported by Public Health Service grant R37-AI019844-24 and T32 predoctoral training grant AI060525 from the National Institute of Allergy and Infectious Diseases. NR 37 TC 13 Z9 13 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2008 VL 76 IS 12 BP 5677 EP 5685 DI 10.1128/IAI.00854-08 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 373WJ UT WOS:000261003900025 PM 18809663 ER PT J AU Noland, GS Hendel-Paterson, B Min, XM Moormann, AM Vulule, JM Narum, DL Lanar, DE Kazura, JW John, CC AF Noland, Gregory S. Hendel-Paterson, Brett Min, Xinan M. Moormann, Ann M. Vulule, John M. Narum, David L. Lanar, David E. Kazura, James W. John, Chandy C. TI Low Prevalence of Antibodies to Preerythrocytic but Not Blood-Stage Plasmodium falciparum Antigens in an Area of Unstable Malaria Transmission Compared to Prevalence in an Area of Stable Malaria Transmission SO INFECTION AND IMMUNITY LA English DT Article ID MEROZOITE SURFACE-ANTIGEN; CLINICAL MALARIA; CIRCUMSPOROZOITE PROTEIN; WESTERN KENYA; HIGHLAND AREA; ADHESIVE PROTEIN; ENDEMIC AREA; RESPONSES; PROTECTION; CHILDREN AB In areas where levels of transmission of Plasmodium falciparum are high and stable, the age-related acquisition of high-level immunoglobulin G (IgG) antibodies to preerythrocytic circumsporozoite protein (CSP) and liver-stage antigen 1 (LSA-1) has been associated with protection from clinical malaria. In contrast, age-related protection from malaria develops slowly or not at all in residents of epidemic-prone areas with unstable low levels of malaria transmission. We hypothesized that this suboptimal clinical and parasitological immunity may in part be due to reduced antibodies to CSP or LSA-1 and/or vaccine candidate blood-stage antigens. Frequencies and levels of IgG antibodies to CSP, LSA-1, thrombospondin-related adhesive protein ( TRAP), apical membrane antigen 1 (AMA-1), erythrocyte binding antigen 175 (EBA-175), and merozoite surface protein 1 (MSP-1) were compared in 243 Kenyans living in a highland area of unstable transmission and 210 residents of a nearby lowland area of stable transmission. Levels of antibodies to CSP, LSA-1, TRAP, and AMA-1 in the oldest age group (>40 years) in the unstable transmission area were lower than or similar to those of children 2 to 6 years old in the stable transmission area. Only 3.3% of individuals in the unstable transmission area had high levels of IgG (>2 arbitrary units) to both CSP and LSA-1, compared to 43.3% of individuals in the stable transmission area. In contrast, antibody levels to and frequencies of MSP-1 and EBA-175 were similar in adults in areas of stable and unstable malaria transmission. Suboptimal immunity to malaria in areas of unstable malaria transmission may relate in part to infrequent high-level antibodies to preerythrocytic antigens and AMA-1. C1 [John, Chandy C.] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA. [Moormann, Ann M.; Kazura, James W.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Vulule, John M.] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Narum, David L.] NIH, Bethesda, MD 20892 USA. [Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP John, CC (reprint author), Univ Minnesota, Dept Pediat, 717 Delaware St,SE Room 363,MC1932, Minneapolis, MN 55455 USA. EM ccj@umn.edu RI John, Chandy/B-4164-2008; Lanar, David/B-3560-2011 FU National Institutes of Allergy and Infectious Diseases [AI01572, AI056270, AI43906] FX This study was supported by grants from the National Institutes of Allergy and Infectious Diseases, AI01572 and AI056270 (C. C. J.) and AI43906 (J. W. K.).; We thank the study participants for their involvement in this study. We thank David Koech, Jackson Abuya, and Livingstone Wanyama for their work in the field collection of these samples and microscopy testing. The sample collection, field work, and initial testing for this study were performed while C. C. J. was at Case Western Reserve University.; This work is published with the permission of the Office of the Director of the Kenya Medical Research Institute. NR 33 TC 22 Z9 22 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2008 VL 76 IS 12 BP 5721 EP 5728 DI 10.1128/IAI.00591-08 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 373WJ UT WOS:000261003900030 PM 18809666 ER PT J AU Rossi, CA Ulrich, M Norris, S Reed, DS Pitt, LM Leffel, EK AF Rossi, Cynthia A. Ulrich, Melanie Norris, Sarah Reed, Douglas S. Pitt, Louise M. Leffel, Elizabeth K. TI Identification of a Surrogate Marker for Infection in the African Green Monkey Model of Inhalation Anthrax SO INFECTION AND IMMUNITY LA English DT Article ID EQUINE ENCEPHALITIS-VIRUS; EXPERIMENTAL RESPIRATORY ANTHRAX; BACILLUS-ANTHRACIS; CYNOMOLGUS MACAQUES; CERCOPITHECUS-AETHIOPS; PROTECTIVE ANTIGEN; AEROSOL EXPOSURE; MACACA MULATTA; RHESUS-MONKEYS; ENTEROTOXIN-B AB In 2001, a bioterrorism attack involving Bacillus anthracis spore-laced letters resulted in 22 cases of inhalation anthrax, with five fatalities. This incident identified gaps in our health care system and precipitated a renewed interest in identifying both therapeutics and rapid diagnostic assays. To address those gaps, well-characterized animal models that resemble the human disease are needed. In addition, a rapid assay for a reliable diagnostic marker is key to the success of these efforts. In this study, we exposed African green monkeys to B. anthracis spores; examined clinical signs and physiological parameters, including fever, heart rate, complete blood count, and bacteremia; and evaluated the PCR assay and electrochemiluminescence (ECL) immunoassay for the biomarkers protective antigen and capsule. The results demonstrated that although there were neither objective clinical nor physiological signs that consistently identified either infection or the onset of clinical anthrax disease, the African green monkey is a suitable animal model exhibiting a disease course similar to that observed in the rhesus model and humans. We also demonstrated that detection of the biomarkers protective antigen and capsule correlated with bacterial loads in the blood of these nonhuman primates. The ECL immunoassay described here is simple and sensitive enough to provide results in one to two hours, making this assay a viable option for use in the diagnosis of anthrax, leading to timely initiation of treatment, which is a key component of B. anthracis therapeutic development. C1 [Rossi, Cynthia A.; Ulrich, Melanie] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Norris, Sarah] USA, Med Res Inst Infect Dis, Res Support Div, Ft Detrick, MD 21702 USA. [Reed, Douglas S.; Pitt, Louise M.; Leffel, Elizabeth K.] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. RP Leffel, EK (reprint author), Natl Biodef Anal & Countermeasures Ctr, Battelle Natl Biodef Inst, 110 Thomas Johnson Dr,Suite 200, Frederick, MD 21702 USA. EM leffele@nbacc.net OI Reed, Douglas/0000-0003-0076-9023 FU National Institute of Allergy and Infectious Diseases, Bethesda,; Joint Science and Technology Office for Chemical and Biological Defense Program, Defense Threat Reduction Agency. FX This research was sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD. Assay development was funded by the Joint Science and Technology Office for Chemical and Biological Defense Program, Defense Threat Reduction Agency.; The views, opinions, and/or findings contained herein are those of the authors and should not be construed as an official Department of Army position, policy, or decision unless so designated by other documentation. The authors do not have a commercial or other association that would pose a conflict of interest.; We are grateful to D. Norwood, P. Hobart, and K. Kenyon for critically reviewing the manuscript, and we thank D. Dyer, S. Coyne, and B. Kearney for their excellent technical assistance. NR 55 TC 23 Z9 23 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 2008 VL 76 IS 12 BP 5790 EP 5801 DI 10.1128/IAI.00520-08 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 373WJ UT WOS:000261003900038 PM 18852240 ER PT J AU Lerdthusnee, K Nigro, J Monkanna, T Leepitakrat, W Leepitakrat, S Insuan, S Charoensongsermkit, W Khlaimanee, N Akkagraisee, W Chayapum, K Jones, JW AF Lerdthusnee, Kriangkrai Nigro, Joseph Monkanna, Taweesak Leepitakrat, Warisa Leepitakrat, Surachai Insuan, Sucheera Charoensongsermkit, Weerayut Khlaimanee, Nittaya Akkagraisee, Wilasinee Chayapum, Kwanta Jones, James W. TI Surveys of rodent-borne disease in Thailand with a focus on scrub typhus assessment SO INTEGRATIVE ZOOLOGY LA English DT Article DE GIS model; rodent-borne diseases; scrub typhus; surveillance surveys AB The epidemiology of many rodent-borne diseases in South-East Asia remains ill-defined. Scrub typhus and leptospirosis are common and medically significant, while other zoonotic diseases, such as spotted fever group Rickettsiae have been identified, but their overall medical significance is unknown. Rodent surveillance was conducted from June 2002 to July 2004 in 18 provinces from Thailand. Traps were set up for one to three nights. Blood and serum samples and animal tissue samples (liver, spleen, kidney and urinary bladder) were collected. Chiggermites, ticks and fleas were removed from captured rodents. A total of 4536 wild-caught rodents from 27 species were captured over two years of animal trapping. Rattus rattus was the dominant species, followed by Rattus exulans and Bandicota indica. Almost 43 000 ectoparasites were removed from the captured animals. Approximately 98% of the ectoparasites were chigger-mites, of which 46% belonged to the genus Leptotrombidium (scrub typhus vector). Other genera included Schoengastia and Blankaartia. Tick and flea specimens together comprised less than 1% of the sample. Among the five species of ticks collected, Haemaphysalis bandicota was the predominant species caught, followed by Ixodes granulatus other Haemaphysalis spp., Rhipicephalus spp. and Dermacentor spp. Only two species of fleas were collected and Xenopsylla cheopis (rat flea) was the predominant species. Using both commercial diagnostic kits and in-house molecular assays, animal tissue samples were examined and screened for zoonotic diseases. Seven zoonotic diseases were detected: scrub typhus, leptospirosis, murine typhus, tick typhus, bartonella, babesiosis and trypanosomiasis. Most samples were positive for scrub typhus. Other zoonotic diseases still under investigation include borrelosis, ehrlichiosis, the plague, and other rickettsial diseases. Using geographic information systems, global positioning systems and remote sensing technology, epidemiological and environmental data were combined to assess the relative risk in different biotopes within highly endemic areas of scrub typhus in Thailand. C1 [Lerdthusnee, Kriangkrai; Monkanna, Taweesak; Leepitakrat, Warisa; Leepitakrat, Surachai; Insuan, Sucheera; Charoensongsermkit, Weerayut; Khlaimanee, Nittaya; Akkagraisee, Wilasinee; Chayapum, Kwanta; Jones, James W.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Nigro, Joseph] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. RP Lerdthusnee, K (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM kriangkrail@afrims.org FU US. Army Medical and Material Command, Fort Detrick, MD, USA FX All animal procedures, field activities and experiments were conducted under the strict guidelines of the Approved Animal Use-Protocols and were approved by AFRIMS's Institutional Animal Care and Use Committee. Funding for this project was provided by the Military Infectious Diseases Research Program of the US. Army Medical and Material Command, Fort Detrick, MD, USA. The views expressed in this paper are those of the authors and do not purport to represent the position and/or reflect the official policy of the Department of the Army, the Department of Defense or the US Government. NR 13 TC 12 Z9 14 U1 1 U2 15 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1749-4877 J9 INTEGR ZOOL JI Integr. Zool. PD DEC PY 2008 VL 3 IS 4 BP 267 EP 273 DI 10.1111/j.1749-4877.2008.00100.x PG 7 WC Zoology SC Zoology GA V15GF UT WOS:000207789800002 PM 21396076 ER PT J AU Hoover, NG Heard, M Reid, C Wagoner, S Rogers, K Foland, J Paden, ML Fortenberry, JD AF Hoover, Nancy G. Heard, Michael Reid, Christopher Wagoner, Scott Rogers, Kristine Foland, Jason Paden, Matthew L. Fortenberry, James D. TI Enhanced fluid management with continuous venovenous hemofiltration in pediatric respiratory failure patients receiving extracorporeal membrane oxygenation support SO INTENSIVE CARE MEDICINE LA English DT Article DE Respiratory failure; Continuous venovenous hemofiltration; Extracorporeal; Hemofiltration; ECMO; Renal failure; Pediatrics; Continuous renal replacement therapy ID RENAL REPLACEMENT THERAPY; PULMONARY-EDEMA; HEARING-LOSS; ILL PATIENTS; DETERMINANTS; CHILDREN; BALANCE AB Background/purpose: Children receiving extracorporeal membrane oxygenation (ECMO) for respiratory failure can have significant fluid overload and renal insufficiency. Addition of inline continuous venovenous hemofiltration (CVVH) could provide additional benefits in fluid management compared to use of standard medical therapies with ECMO. Methods: Patients with pediatric respiratory failure receiving ECMO with CVVH were case-matched to similar patients receiving ECMO without CVVH to compare fluid balance, medication use, and clinical outcomes. Results: Twenty-six of eighty-six patients with pediatric respiratory failure on ECMO (30%) received CVVH for > 24 h (median 7.5 days on CVVH). Survival was not significantly different between patients receiving CVVH and those who did not receive CVVH (P = 0.51). For ECMO survivors receiving CVVH, overall fluid balance was less than that in non-CVVH survivors (median 25.1 ml kg(-1) stop day(-1); range -40.2 to 71.2 vs. 40.2, 1.1 to 134.9; P = 0.028). Time to desired caloric intake was faster in patients receiving CVVH (1 day, 1-5) than in patients who did not receive CVVH (5 days; 1-11; P < 0.001). Patients receiving CVVH-ECMO also received less furosemide (0.67 vs. 2.11 mg kg(-1) day (-1); P = 0.009). Conclusions: Use of CVVH in ECMO was associated with improved fluid balance and caloric intake and less diuretics than in case-matched ECMO controls. C1 [Paden, Matthew L.; Fortenberry, James D.] Childrens Healthcare Atlanta Egleston, Div Crit Care Med, Atlanta, GA 30322 USA. [Hoover, Nancy G.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Paden, Matthew L.; Fortenberry, James D.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA. [Heard, Michael; Reid, Christopher; Wagoner, Scott] Childrens Healthcare Atlanta Egleston, Div ECMO & Adv Technol, Atlanta, GA 30322 USA. RP Fortenberry, JD (reprint author), Childrens Healthcare Atlanta Egleston, Div Crit Care Med, 1405 Clifton Rd NE, Atlanta, GA 30322 USA. EM james.fortenberry@choa.org NR 24 TC 48 Z9 49 U1 0 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0342-4642 J9 INTENS CARE MED JI Intensive Care Med. PD DEC PY 2008 VL 34 IS 12 BP 2241 EP 2247 DI 10.1007/s00134-008-1200-y PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 374SA UT WOS:000261062800017 PM 18629472 ER PT J AU Nicolaides, A Goldhaber, SZ Maxwell, GL Labropoulos, N Clarke-Pearson, DL Tyllis, TH Griffin, MB AF Nicolaides, A. Goldhaber, S. Z. Maxwell, G. L. Labropoulos, N. Clarke-Pearson, D. L. Tyllis, T. H. Griffin, M. B. TI Cost benefit of intermittent pneumatic compression for venous thromboembolism prophylaxis in general surgery SO INTERNATIONAL ANGIOLOGY LA English DT Article DE Venous thrombosis; Thromboembolism; Cost-benefit analysis ID DEEP-VEIN THROMBOSIS; SUSPECTED PULMONARY-EMBOLISM; 3 SIMPLE DECISIONS; DIAGNOSIS; PREVENTION; ULTRASOUND; GUIDELINES; MANAGEMENT; TRIAL AB Aim. In moderate to high-risk general surgical patients, the cost effectiveness of mechanical prophylaxis for venous thromboembolism (VTE) is uncertain. Therefore, we determined the costs and savings of intermittent pneumatic compression (IPC) plus graduated compression stockings (GCS). Methods. Postoperative VTE events in the absence of prophylaxis, efficacy of prophylaxis and costs of prophylaxis have been obtained from the English literature and Medicare 2004 reimbursement schedule. Results. In 1000 moderate to high risk general surgical patients, in the absence of prophylaxis, the cost of investigating and treating 72 patients with clinical suspicion of DVT and 32 with PE is calculated to be $ 263 779. This corresponds to a cost of $ 263 per surgical patient. The cost of IPC combined with TED stockings in 1000 similar patients would be $ 66 760, and the cost of diagnosis and treatment of the reduced numbers (69% reduction) of clinical VTE is $ 83 574 making a total of $ 150 344. This means a saving of $ 133 435 ($ 263 779-$ 150 344) per 1 000 patients. This corresponds to a saving of $ 113 per surgical patient. Sensitivity analysis demonstrates that despite variation in costs or efficacy for IPC plus GCS, marked savings persist. Conclusion. Prophylaxis with IPC not only prevents VTE but also saves money. C1 [Nicolaides, A.; Tyllis, T. H.] Vasc Screening & Diagnost Ctr, CY-2368 Nicosia, Cyprus. [Nicolaides, A.] Univ London Imperial Coll Sci Technol & Med, Dept Vasc Surg, London, England. [Nicolaides, A.] Univ Cyprus, Dept Biol Sci, Nicosia, Cyprus. [Goldhaber, S. Z.] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA. [Maxwell, G. L.] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. [Labropoulos, N.] Univ Med & Dent New Jersey, Dept Vasc Surg, Newark, NJ 07103 USA. [Labropoulos, N.] Univ Med & Dent New Jersey, Vasc Lab, Newark, NJ 07103 USA. [Clarke-Pearson, D. L.] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA. [Griffin, M. B.] Vasc Screening & Diagnost Ctr, London, England. RP Nicolaides, A (reprint author), Vasc Screening & Diagnost Ctr, 2 Ayios Dhometios, CY-2368 Nicosia, Cyprus. EM anicolai@cytanet.com.cy NR 36 TC 10 Z9 14 U1 0 U2 4 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0392-9590 EI 1827-1839 J9 INT ANGIOL JI Int. Angiol. PD DEC PY 2008 VL 27 IS 6 BP 500 EP 506 PG 7 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 410BZ UT WOS:000263552200008 PM 19078913 ER PT J AU Huang, LH Xie, J Chen, RR Chu, D Chu, W Hsu, AT AF Huang, Lihong Xie, Jian Chen, Rongrong Chu, Deryn Chu, Wei Hsu, Andrew T. TI Effect of iron on durability of nickel-based catalysts in auto-thermal reforming of ethanol for hydrogen production SO INTERNATIONAL JOURNAL OF HYDROGEN ENERGY LA English DT Article DE Durability; Iron promoter; Nickel catalyst; Hydrogen production; Auto-thermal reforming; Ethanol ID BIO-ETHANOL; FUEL-CELL; SUPPORTED CATALYSTS; RH/AL2O3 CATALYST; METAL-CATALYSTS; H-2 PRODUCTION; STEAM; NI; TEMPERATURE; PERFORMANCE AB iron-promoted nickel-based catalysts were prepared by impregnation, tested in auto-thermal reforming (ATR) of ethanol for hydrogen production, and characterized by TPR, XRD, BET, TEM, and XPS. With the introduction of iron, mixed crystals of NiAl(2)O(4)-FeAl(2)O(4) spinel phase are formed, which results in modifications of its structural and electronic properties. The reaction results show a remarkable improvement on durability in catalytic activity as well as selectivity to hydrogen in ATR: over the 10 wt.% iron-loading nickel catalyst, conversion of ethanol at 99.61% and selectivity of hydrogen around 115% are kept at 600 degrees C during a 30-h test, while that of iron-free sample decreases sharply from 85.10% to 19.71% on hydrogen selectivity within a 26-h test. The improved durability is attributed to the synergistic effect of the NiAl(2)O(4)-FeAl(2)O(4) mixed crystals that are more resistant to sintering and oxidation in the oxidative atmosphere of ATR. (C) 2008 International Association for Hydrogen Energy. Published by Elsevier Ltd. All rights reserved. C1 [Huang, Lihong; Xie, Jian; Chen, Rongrong; Chu, Wei; Hsu, Andrew T.] Indiana Univ Purdue Univ, Purdue Sch Engn & Technol, Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Hsu, AT (reprint author), Indiana Univ Purdue Univ, Purdue Sch Engn & Technol, Lugar Ctr Renewable Energy, 799 W Michigan St,ET 215, Indianapolis, IN 46202 USA. EM anhsu@iupui.edu RI Chu, Wei/I-4486-2013; Chu, Wei/C-6140-2011 OI Chu, Wei/0000-0002-7166-5443 FU U.S. Army Research Lab [W911NF-07-2-0036] FX The research work is partially supported by the U.S. Army Research Lab (Grant No. W911NF-07-2-0036). The authors wish to thank Dr. Jeffrey Swope of Department of Geography Science at 1UPUI for XRD test, and to Dr. Dmitry Zemlyanov of Birck Nanotechnology Center of Purdue University for XPS characterizations, and acknowledge the useful discussions provided by Drs. Muhua Chen, Dong Xie, Guigui Wang, Luhua Jiang and Mr. Michael Reed. NR 32 TC 32 Z9 32 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-3199 J9 INT J HYDROGEN ENERG JI Int. J. Hydrog. Energy PD DEC PY 2008 VL 33 IS 24 BP 7448 EP 7456 DI 10.1016/j.ijhydene.2008.09.062 PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels SC Chemistry; Electrochemistry; Energy & Fuels GA 389FX UT WOS:000262077900017 ER PT J AU Alexander, CS Chhabildas, LC Reinhart, WD Templeton, DW AF Alexander, C. S. Chhabildas, L. C. Reinhart, W. D. Templeton, D. W. TI Changes to the shock response of fused quartz due to glass modification SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article; Proceedings Paper CT 10th Hypervelocity Impact Symposium (HVIS 2007) CY SEP 23-27, 2007 CL Williamsburg, VA DE Shock; Glass; Random network model; Glass modifiers; Fused silica ID SODA-LIME GLASS; WAVE COMPRESSION; STISHOVITE; BEHAVIOR; RELEASE AB Silica based glasses are commonly used as window material in applications which are subject to high velocity impacts. Thorough understanding of the response to shock loading in these materials is crucial to the development of new designs. Despite the lack of long range order in amorphous glasses, the structure can be described statistically by the random network model. Changes to the network structure alter the response to shock loading. Results indicate that in fused silica, substitution of boron as a network former does not have a large effect on the shock loading properties while modifying the network with sodium and calcium changes the dynamic response. These initial results suggest the potential of a predictive capability to determine the effects of other network substitutions. Published by Elsevier Ltd. C1 [Alexander, C. S.; Chhabildas, L. C.; Reinhart, W. D.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Templeton, D. W.] US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI 48397 USA. RP Alexander, CS (reprint author), Sandia Natl Labs, Albuquerque, NM 87185 USA. EM calexa@sandia.gov NR 26 TC 37 Z9 39 U1 1 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2008 VL 35 IS 12 BP 1376 EP 1385 DI 10.1016/j.ijimpeng.2008.07.019 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 392YQ UT WOS:000262338500004 ER PT J AU McFarland, C Papados, P Giltrud, M AF McFarland, C. Papados, P. Giltrud, M. TI Hypervelocity impact penetration mechanics SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article; Proceedings Paper CT 10th Hypervelocity Impact Symposium (HVIS 2007) CY SEP 23-27, 2007 CL Williamsburg, VA DE Penetration; Tungsten; Strength; Erosion; Limestone AB Inert dense metal penetrators having a mass and geometry capable of missile delivery offer significant potential for countering underground facilities at depths of tens of meters in hard rock. The proliferation of such facilities among countries whose support for terrorism and potential possession of Weapons of Mass Destruction (WMD) constitutes threats to world peace and U.S. Security. The Defense Threat Reduction Agency (DTRA), in cooperation with the U.S. Army Corps of Engineers, the Department of Energy National Laboratories and private sector R&D firms have pursued an aggressive research effort to explore the attributes of high velocity impact penetrators for countering such facilities. The penetration of crustal rocks with metal rods (such as tungsten or steel alloys) at high velocities involves complex wave propagation phenomena within the rod and inelastic response of both the penetrator and target material. In this paper we examine the sensitivity of penetration depth (for a fixed tungsten alloy mass impacting a limestone target) to impactor velocity, strength and geometry. Analyses are based upon a matrix of first principle finite difference calculations using the Sandia CTH (release 7.1) Shock Physics Code. Results indicate that impact velocity, penetrator yield strength and target yield strength strongly influence the penetration depth. Maximum penetration depth is achieved by a delicate trade off between penetrator kinetic energy and penetrator inelastic deformation (erosion). Numerical analyses for the parameter variations exercised in this study (impact velocities 1-3.5 km/s and penetrator yield strengths of 1-4 GPa) produced penetration depths of a tungsten alloy rod (length 200 cm, diameter 20 cm) which varied from 5.1 m to 28 m in a homogeneous limestone target. (C) 2008 Elsevier Ltd. All rights reserved. C1 [McFarland, C.] SAIC Inc, Alexandria, VA 22304 USA. [Papados, P.] US Army Corps Engn, Engn Res & Dev Ctr, Alexandria, VA 22315 USA. [Giltrud, M.] Def Threat Reduct Agcy, Ft Belvoir, VA 22060 USA. RP McFarland, C (reprint author), SAIC Inc, 4875 Eisenhower Ave, Alexandria, VA 22304 USA. EM clifton.b.mcfarland@saic.com NR 10 TC 1 Z9 1 U1 2 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2008 VL 35 IS 12 BP 1654 EP 1660 DI 10.1016/j.ijimpeng.2008.07.080 PG 7 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 392YQ UT WOS:000262338500046 ER PT J AU Raftenberg, MN Mock, W Kirby, GC AF Raftenberg, M. N. Mock, W., Jr. Kirby, G. C. TI Modeling the impact deformation of rods of a pressed PTFE/Al composite mixture SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article; Proceedings Paper CT 10th Hypervelocity Impact Symposium (HVIS 2007) CY SEP 23-27, 2007 CL Williamsburg, VA DE Polytetrafluoroethylene; PTFE/Al; Split Hopkinson bar; Taylor anvil; Johnson-Cook strength AB Finite element simulations have been performed for the impact onto steel anvils of solid rods of a pressed composite mixture of polytetrafluoroethylene (PTFE) and aluminum powders. Photographs of the reactive rods prior to significant impact initiation for three previously performed experiments at impact velocities of 104, 222, and 466 m/s have been digitized for comparison with the simulations Simulations. were performed using the Johnson-Cook and PSDam strength models Parameters for the PSDam model. have been previously determined for this PTFE/Al mixture. The results of Instron compression tests and high-rate slit Hopkinson bar experiments were used to determine the parameters for the Johnson-Cook model. The Johnson-Cook model produced reasonable agreement with the experimental specimen shape at 104 m/s. PSDam produced reasonable agreement at early times for the 222 m/s experiment. Published by Elsevier Ltd. C1 [Raftenberg, M. N.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Mock, W., Jr.; Kirby, G. C.] USN, Ctr Surface Warfare, Dahlgren Div, Dahlgren, VA 22448 USA. RP Raftenberg, MN (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mnr@arl.army.mil NR 11 TC 16 Z9 26 U1 8 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2008 VL 35 IS 12 BP 1735 EP 1744 DI 10.1016/j.ijimpeng.2008.07.041 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 392YQ UT WOS:000262338500059 ER PT J AU Sorensen, BR Kimsey, KD Love, BM AF Sorensen, B. R. Kimsey, K. D. Love, B. M. TI High-velocity impact of low-density projectiles on structural aluminum armor SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article; Proceedings Paper CT 10th Hypervelocity Impact Symposium (HVIS 2007) CY SEP 23-27, 2007 CL Williamsburg, VA DE Hypervelocity impact; KE projectiles; Low-density projectiles; Aluminum armor ID LONG-ROD PENETRATION; MODEL AB The US Army Research Laboratory has been studying the impact physics of low-density projectiles on urban and light-armor structures for use in electro-magnetic cannons. In this paper, results of low-aspect ratio projectiles of nylon, aluminum and steel impacting aluminum armor at velocities above 2000 m/s will be presented. Both computational solid mechanics and analytic modeling techniques were used to supplement experiments to derive a toolkit for assessing target response and character of the debris created from different constant energy impact conditions. Published by Elsevier Ltd. C1 [Sorensen, B. R.; Kimsey, K. D.; Love, B. M.] USA, Res Lab, AMSRD ARL WM TC, Aberdeen Proving Ground, MD 21005 USA. RP Sorensen, BR (reprint author), USA, Res Lab, AMSRD ARL WM TC, Aberdeen Proving Ground, MD 21005 USA. EM sorensen@arl.army.mil NR 7 TC 6 Z9 6 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2008 VL 35 IS 12 BP 1808 EP 1815 DI 10.1016/j.ijimpeng.2008.07.077 PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 392YQ UT WOS:000262338500068 ER PT J AU Garcon, N Van Mechelen, M Leroux-Roels, G Stanberry, L Osterhaus, A Heppner, G Kester, KE Polhemus, M Horsmans, Y Cohen, J AF Garcon, N. Van Mechelen, M. Leroux-Roels, G. Stanberry, L. Osterhaus, A. Heppner, G. Kester, K. E. Polhemus, M. Horsmans, Y. Cohen, J. TI Vaccines Adjuvanted with Adjuvant Systems - from Concept to Clinical Evidence SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Garcon, N.; Van Mechelen, M.; Cohen, J.] GlaxoSmithKline Biol, Rixensart, 10027, Belgium. [Leroux-Roels, G.] Ghent Univ & Hosp, Ctr Vaccinol, Ghent, Belgium. [Stanberry, L.] Columbia Univ, Dept Pediat, New York, NY USA. [Osterhaus, A.] Erasmus MC, Dept Virol, Rotterdam, Netherlands. [Heppner, G.; Kester, K. E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Polhemus, M.] Walter Reed Project, Kisumu, Kenya. [Horsmans, Y.] St Luc Univ Hosp, Brussels, Belgium. RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 SU 1 BP E151 EP E151 DI 10.1016/j.ijid.2008.05.374 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800373 ER PT J AU Klein, T Baek, L Kim, H O'Guinn, M Lee, J Turell, M Richards, A Sames, W Chong, S Graf, P Song, J AF Klein, T. Baek, L. Kim, H. O'Guinn, M. Lee, J. Turell, M. Richards, A. Sames, W. Chong, S. Graf, P. Song, J. TI Rodent-borne Disease Surveillance at US Military Training Sites Near the Demilitarized Zone, Republic of Korea SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES LA English DT Meeting Abstract C1 [Klein, T.; Kim, H.; Chong, S.] 18th Med Command, Seoul, South Korea. [Baek, L.; Song, J.] Korea Univ, Dept Microbiol, Seoul, South Korea. [O'Guinn, M.; Lee, J.; Turell, M.] USA, Med Res Inst Infect Dis, Dept Virol, Frederick, MD USA. [Richards, A.; Graf, P.] Dept Naval Med Res Ctr, Silver Spring, MD USA. [Sames, W.] Def Logist Agcy, Ft Belvoir, VA USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1201-9712 J9 INT J INFECT DIS JI Int. J. Infect. Dis. PD DEC PY 2008 VL 12 BP E86 EP E86 DI 10.1016/j.ijid.2008.05.214 PG 1 WC Infectious Diseases SC Infectious Diseases GA 406II UT WOS:000263287800213 ER PT J AU Kalb, SR Smith, TJ Moura, H Hill, K Lou, JL Geren, IN Garcia-Rodriguez, C Marks, JD Smith, LA Pirkle, JL Barr, JR AF Kalb, Suzanne R. Smith, Theresa J. Moura, Hercules Hill, Karen Lou, Jianlong Geren, Isin N. Garcia-Rodriguez, Consuelo Marks, James D. Smith, Leonard A. Pirkle, James L. Barr, John R. TI The use of Endopep-MS to detect multiple subtypes of botulinum neurotoxins A, B, E, and F SO INTERNATIONAL JOURNAL OF MASS SPECTROMETRY LA English DT Article DE Botulinum neurotoxin; Botulism; Mass spectrometry ID CLOSTRIDIUM-BOTULINUM; NUCLEOTIDE-SEQUENCE; MASS-SPECTROMETRY; INFANT BOTULISM; BINDING DOMAIN; ANTIBODY; TOXIN; GENE; STRAINS; CHAIN AB Botulinum neurotoxins (BoNTs) cause the disease botulism, which can be lethal if untreated. Rapid determination of exposure to BoNT is an important public health goal. Previous work in our laboratory focused on the development of Endopep-MS, a mass spectrometry-based endopeptidase method for detecting and differentiating BoNT A-G in buffer and BoNT A, B, E, and F in clinical samples. We introduce here the use of Endeopep-MS to detect non-commercial subtypes of BoNT A, B, E, and F which have been associated with botulism outbreaks. We have now tested and successfully detected 15 of the 17 known subtypes of BoNT A, B, E, and F by Endopep-MS. Extraction of BoNT A and B from a complex mixture prior to analysis is accomplished by using monoclonal antibodies specific for the catalytically inactive heavy chain of the toxin. These antibodies have high-binding affinities and do not interfere with the catalytic activity of the light chain resulting in a lower limit of detection for BoNT A and B than previously reported. We also report for the first time limits of detection for BoNT A2, A3, B2, and bivalent B using Endopep-MS. Published by Elsevier B.V. C1 [Kalb, Suzanne R.; Moura, Hercules; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, NCEH, DLS, Atlanta, GA 30341 USA. [Smith, Theresa J.; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Hill, Karen] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Lou, Jianlong; Geren, Isin N.; Garcia-Rodriguez, Consuelo; Marks, James D.] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Anesthesia & Pharmaceut Chem, San Francisco, CA 94110 USA. RP Barr, JR (reprint author), Ctr Dis Control & Prevent, NCEH, DLS, 4770 Buford Highway NE,Mailstop F-44, Atlanta, GA 30341 USA. EM jbarr@cdc.gov FU NIAID cooperative [U01 A1056493, 200-2006-16697]; CDC [200-2006-16697] FX The authors acknowledge several funding sources for the production of monoclonal antibodies: NIAID cooperative agreement U01 A1056493 (JDM), DoD contract DAMD17-03-C-0076 UDM), UC MEXUS-CONACYT Faculty Visit Fellowship (CG), and CDC contract 200-2006-16697 UDM). NR 33 TC 29 Z9 29 U1 1 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1387-3806 J9 INT J MASS SPECTROM JI Int. J. Mass Spectrom. PD DEC 1 PY 2008 VL 278 IS 2-3 BP 101 EP 108 DI 10.1016/j.ijms.2008.04.004 PG 8 WC Physics, Atomic, Molecular & Chemical; Spectroscopy SC Physics; Spectroscopy GA 378EM UT WOS:000261304000002 ER PT J AU Keller, CB AF Keller, Christian B. TI Counter-Thrust: From the Peninsula to the Antietam. SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Keller, Christian B.] USA, Command & Gen Staff Coll, Ft Belvoir, VA 22060 USA. RP Keller, CB (reprint author), USA, Command & Gen Staff Coll, Ft Belvoir, VA 22060 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD DEC PY 2008 VL 95 IS 3 BP 857 EP 858 PG 2 WC History SC History GA 383GC UT WOS:000261661100064 ER PT J AU Andrade, D AF Andrade, Dale TI Vietnam's Forgotten Army: Heroism and Betrayal in the ARVN SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Andrade, Dale] USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Andrade, D (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD DEC PY 2008 VL 95 IS 3 BP 918 EP 919 PG 2 WC History SC History GA 383GC UT WOS:000261661100135 ER PT J AU Chen, Y Farrell, S Brill, G Wijewarnasuriya, P Dhar, N AF Chen, Y. Farrell, S. Brill, G. Wijewarnasuriya, P. Dhar, N. TI Dislocation reduction in CdTe/Si by molecular beam epitaxy through in-situ annealing SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Dislocation; Molecular beam epitaxy; CdTe; HgCdTe; Si; Etched pit density; Annealing ID DENSITY REDUCTION; INFRARED HGCDTE; MBE GROWTH; SILICON; DETECTORS; CDZNTE; ZNTE AB The relatively high dislocation density of HgCdTe material grown on CdTe/Si by MBE has become a major roadblock toward achieving high operability of LWIR HgCdTe/Si FPAs. One approach to mitigate this problem is to reduce the dislocation density of the underlying CdTe/Si composite substrate, which is currently about two orders higher than that of bulk CdZnTe. In this paper, we will report on our systematic study of in-situ cyclic annealing of CdTe/Si and its impact on dislocation density. We observed a two orders of magnitude reduction of dislocation density on in-situ annealed CdTe/Si with respect to un-annealed CdTe/Si. The degree of reduction is proportional to the number of annealing cycles applied during the growth run. Depth profiling of the dislocation density of CdTe/Si layers with and without in-situ cyclic annealing has also been investigated. We do not observe the conventional 1/h behavior of the dislocation density for layers grown without any thermal treatment. In contrast, for the layer grown with in-situ cyclic annealing, we observe an exponential decay of dislocation density as a function of layer thickness. However, we also observe a saturation of dislocation density in low to mid 10(5) cm(-2), regardless of the annealing temperature and number of the cycles used during annealing. Published by Elsevier B.V. C1 [Chen, Y.; Brill, G.; Wijewarnasuriya, P.; Dhar, N.] USA, Res Lab, Adelphi, MD 20783 USA. [Farrell, S.] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. RP Chen, Y (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yuanping.chen@us.army.mil RI Brill, Gregory/G-4877-2013 FU Penn State Electro-Optics Center [N00024-02-D-6604]; Army Research Office [W911NF-07-2-0055] FX Authors would like to thank J. G. Tischler at Naval Research Laboratory for measuring low-temperature photoluminescence on our samples. One of us, Mr. Stuart Farrell, would like to acknowledge helpful discussions with Prof. Mulpuri at George Mason University and financial support provided by Penn State Electro-Optics Center under contract N00024-02-D-6604 and Army Research Office under grant W911NF-07-2-0055. NR 16 TC 43 Z9 47 U1 2 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD DEC 1 PY 2008 VL 310 IS 24 BP 5303 EP 5307 DI 10.1016/j.jcrysgro.2008.09.023 PG 5 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 390WH UT WOS:000262193900012 ER PT J AU Bernier-Rodriguez, JA Sidow, SJ Joyce, AP McNally, K McPherson, JC AF Bernier-Rodriguez, Joseph A. Sidow, Stephanie J. Joyce, Anthony P. McNally, Kathleen McPherson, James C., III TI Radiographic Interpretation of Experimental Lesions in Radicular Tooth Structure of Human Maxillary Anterior Teeth SO JOURNAL OF ENDODONTICS LA English DT Article DE External resorption; radicular; radiograph; radiographic detection ID BONY LESIONS; PERIAPICAL LESIONS AB External resorption is often first detected radiographically. Early detection can lead to timely intervention and improvement of treatment outcome. The purpose of this study was to determine the minimal radicular defect size in maxillary anterior teeth that is radiographically detectable. Six teeth were selected in a cadaver maxilla (#6-11) and extracted. The teeth were then replanted in the maxilla, and three horizontally angled radiographs (0 degrees, 30 degrees from the mesial, and 30 degrees from the distal) were exposed as a baseline. Then, a sequence of tooth removal, placement of a 0.1-mm deep defect in the interproximal and midroot surface, tooth replantation, and radiograph exposure was begun and repeated eight times. Each time the defect depth was increased by 0.1 mm. Ten clinicians interpreted the subsequent radiographs to determine if they visualized a defect on each tooth and the location of the defect. The evaluators' ability to detect experimental lesions according to the depth of the defect was shown to be statistically significant for both tooth type and location of the radicular defect (analysis of variance, p < 0.05). The average size of defect needed for radiographic visualization was as follows: central incisor (0.28 mm on the interproximal [IP] and 0.74 mm on the midroot [MR] [palatal], lateral incisor (0.39 mm on the IP and 0.55 mm on the MR); and canine [0.45 mm on the IP and 0.71 mm on the MR). Based on the results of this study, the minimal defect size detected was 0.28 mm to 0.74 mm depending on defect location and tooth selected. (J Endod 2008;34:1466-1469) C1 [Bernier-Rodriguez, Joseph A.; Sidow, Stephanie J.; McNally, Kathleen] USA, Endodont Residency Program, Ft Gordon, GA USA. [Joyce, Anthony P.] USA, Dent Activ, Schofield Barracks, HI USA. [McPherson, James C., III] USA, Dept Clin Invest, Ft Gordon, GA USA. RP Bernier-Rodriguez, JA (reprint author), Ft Campbell Dent Act, 2441 21st St, Ft Campbell, KY 42223 USA. EM joseph.bernier@us.army.mil NR 24 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD DEC PY 2008 VL 34 IS 12 BP 1466 EP 1469 DI 10.1016/j.joen.2008.09.009 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 382RN UT WOS:000261623200007 PM 19026875 ER PT J AU Davis, RE Painter, TH Cline, D Armstrong, R Haran, T McDonald, K Forster, R Elder, K AF Davis, Robert E. Painter, Thomas H. Cline, Don Armstrong, Richard Haran, Terry McDonald, Kyle Forster, Rick Elder, Kelly TI NASA Cold Land Processes Experiment (CLPX 2002/03): Spaceborne Remote Sensing SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID SNOW WATER EQUIVALENT; THEMATIC MAPPER; GRAIN-SIZE; COVER; RESOLUTION; RETRIEVAL AB This paper describes satellite data collected as part of the 2002/03 Cold Land Processes Experiment (CLPX). These data include multispectral and hyperspectral optical imaging, and passive and active microwave observations of the test areas. The CLPX multispectral optical data include the Advanced Very High Resolution Radiometer (AVHRR), the Landsat Thematic Mapper/Enhanced Thematic Mapper Plus (TM/ETM +), the Moderate Resolution Imaging Spectroradiometer ( MODIS), and the Multi-angle Imaging Spectroradiometer (MISR). The spaceborne hyperspectral optical data consist of measurements acquired with the NASA Earth Observing-1 (EO-1) Hyperion imaging spectrometer. The passive microwave data include observations from the Special Sensor Microwave Imager (SSM/I) and the Advanced Microwave Scanning Radiometer (AMSR) for Earth Observing System (EOS; AMSR-E). Observations from the Radarsat synthetic aperture radar and the SeaWinds scatterometer flown on QuikSCAT make up the active microwave data. C1 [Davis, Robert E.] USACE, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Painter, Thomas H.; Forster, Rick] Univ Utah, Dept Geog, Salt Lake City, UT USA. [Cline, Don] Natl Weather Serv, Natl Operat Remote Sensing Hydrol Ctr, Chanhassen, MN USA. [Armstrong, Richard; Haran, Terry] Univ Colorado, Natl Snow & Ice Data Ctr, Boulder, CO 80309 USA. [McDonald, Kyle] CALTECH, Jet Prop Lab, Pasadena, CA USA. [Elder, Kelly] US Forest Serv, Rocky Mt Res Stn, USDA, Ft Collins, CO USA. RP Davis, RE (reprint author), USACE, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM robert.e.davis@erdc.usace.army.mil RI Painter, Thomas/B-7806-2016 FU National Aeronautics and Space Administration (NASA) Earth Science Enterprise; Terrestrial Hydrology Program; Earth Observing System Program; Airborne Science Program; National Oceanic and Atmospheric Administration Office of Global Programs; U. S. Army Corps of Engineers Civil Works Remote Sensing Research Program; the U. S. Army Basic Research Program; National Space Development Agency of Japan (NASDA); Japan Science and Technology Corporation; National Assembly for Wales; Science Research Investment Fund; Cardiff University; Jet Propulsion Laboratory at the California Institute of Technology FX This work was funded through the cooperation of many agencies and organizations including the National Aeronautics and Space Administration (NASA) Earth Science Enterprise, Terrestrial Hydrology Program, Earth Observing System Program, and Airborne Science Program; the National Oceanic and Atmospheric Administration Office of Global Programs; the U. S. Army Corps of Engineers Civil Works Remote Sensing Research Program; the U. S. Army Basic Research Program; the National Space Development Agency of Japan (NASDA); the Japan Science and Technology Corporation; and the National Assembly for Wales, Science Research Investment Fund, Cardiff University. A portion of this work was conducted at the Jet Propulsion Laboratory at the California Institute of Technology, under contract to NASA. More than 200 people participated in the planning and execution of CLPX 2002/03. Their efforts are very much appreciated. We would also like to thank the two anonymous and thorough reviewers who helped to improve the manuscript. NR 30 TC 4 Z9 4 U1 0 U2 5 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD DEC PY 2008 VL 9 IS 6 BP 1427 EP 1433 DI 10.1175/2008JHM926.1 PG 7 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 386DD UT WOS:000261861600019 ER PT J AU Hardy, J Davis, R Koh, Y Cline, D Elder, K Armstrong, R Marshall, HP Painter, T Saint-Martin, GC Deroo, R Sarabandi, K Graf, T Koike, T McDonald, K AF Hardy, Janet Davis, Robert Koh, Yeohoon Cline, Don Elder, Kelly Armstrong, Richard Marshall, Hans-Peter Painter, Thomas Saint-Martin, Gilles Castres Deroo, Roger Sarabandi, Kamal Graf, Tobias Koike, Toshio McDonald, Kyle TI NASA Cold Land Processes Experiment (CLPX 2002/03): Local Scale Observation Site SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article AB The local scale observation site (LSOS) is the smallest study site (0.8 ha) of the 2002/03 Cold Land Processes Experiment (CLPX) and is located within the Fraser mesocell study area. It was the most intensively measured site of the CLPX, and measurements here had the greatest temporal component of all CLPX sites. Measurements made at the LSOS were designed to produce a comprehensive assessment of the snow, soil, and vegetation characteristics viewed by the ground-based remote sensing instruments. The objective of the ground-based microwave remote sensing was to collect time series of active and passive microwave spectral signatures over snow, soil, and forest, which is coincident with the intensive physical characterization of these features. Ground-based remote sensing instruments included frequency modulated continuous wave (FMCW) radars operating over multiple microwave bandwidths; the Ground-Based Microwave Radiometer (GBMR-7) operating at channels 18.7, 23.8, 36.5, and 89 GHz; and in 2003, an L-, C-, X- and Ku-band scatterometer radar system. Snow and soil measurements included standard snow physical properties, snow wetness, snow depth transects, and soil moisture. The stem and canopy temperature and xylem sap flux of several trees were monitored continuously. Five micrometeorological towers monitored ambient conditions and provided forcing datasets for 1D snow and soil models. Arrays of pyranometers (0.3-3 mu m) and a scanning thermal radiometer (8-12 mu m) characterized the variability of radiative receipt in the forests. A field spectroradiometer measured the hyperspectral hemispherical-directional reflectance of the snow surface. These measurements, together with the ground-based remote sensing, provide the framework for evaluating and improving microwave radiative transfer models and coupling them to land surface models. The dataset is archived at the National Snow and Ice Data Center (NSIDC) in Boulder, Colorado. C1 [Hardy, Janet; Davis, Robert; Koh, Yeohoon] US Army Corps Engineers, Engn Res & Dev Ctr, CRREL, Hanover, NH 03755 USA. [Cline, Don] NOAA, NWS, Natl Operat Hydrol Remote Sensing Ctr, Chanhassen, MN USA. [Elder, Kelly] US Forest Serv, USDA, Ft Collins, CO USA. [Armstrong, Richard; Marshall, Hans-Peter] Univ Colorado, Boulder, CO 80309 USA. [Painter, Thomas] Univ Utah, Salt Lake City, UT USA. [Saint-Martin, Gilles Castres; Deroo, Roger; Sarabandi, Kamal] Univ Michigan, Ann Arbor, MI 48109 USA. [Graf, Tobias; Koike, Toshio] Univ Tokyo, Tokyo, Japan. [McDonald, Kyle] CALTECH, Jet Prop Lab, NASA, Pasadena, CA USA. RP Hardy, J (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM janet.p.hardy@usace.army.mil RI Marshall, Hans-Peter/A-2374-2010; De Roo, Roger/J-2208-2012; Painter, Thomas/B-7806-2016 OI Marshall, Hans-Peter/0000-0002-4852-5637; De Roo, Roger/0000-0001-8391-2950; FU National Aeronautics and Space Administration (NASA); U. S. Army Corps of Engineers Civil Works Remote Sensing Research Program; U. S. Army Basic Research Program; Japan Aerospace Exploration Agency (JAXA); Japan Science and Technology Agency; National Assembly for Wales; Strategic Research Investment Fund, Cardiff; Jet Propulsion Laboratory at the California Institute of Technology FX This work was funded through cooperation of many agencies and organizations including the National Aeronautics and Space Administration (NASA), the U. S. Army Corps of Engineers Civil Works Remote Sensing Research Program, the U. S. Army Basic Research Program, the Japan Aerospace Exploration Agency (JAXA), the Japan Science and Technology Agency, and the National Assembly for Wales, Strategic Research Investment Fund, Cardiff. A portion of this work was conducted at the Jet Propulsion Laboratory at the California Institute of Technology, under contract to NASA. NR 12 TC 6 Z9 8 U1 0 U2 5 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD DEC PY 2008 VL 9 IS 6 BP 1434 EP 1442 DI 10.1175/2008JHM875.1 PG 9 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 386DD UT WOS:000261861600020 ER PT J AU Frankenstein, S Sawyer, A Koeberle, J AF Frankenstein, Susan Sawyer, Anne Koeberle, Julie TI Comparison of FASST and SNTHERM in Three Snow Accumulation Regimes SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID ENERGY-BALANCE; BOREAL FOREST; STAND-SCALE; MODEL; COVER; ABLATION; BASIN; HEAT; PARAMETERIZATION; SIMULATION AB Numerical experiments of snow accumulation and depletion were carried out as well as surface energy fluxes over four Cold Land Processes Experiment (CLPX) sites in Colorado using the Snow Thermal model (SNTHERM) and the Fast All-Season Soil Strength model (FASST). SNTHERM is a multilayer snow model developed to describe changes in snow properties as a function of depth and time, using a one-dimensional mass and energy balance. The model is intended for seasonal snow covers and addresses conditions found throughout the winter, from initial ground freezing in the fall to snow ablation in the spring. It has been used by many researchers over a variety of terrains. FASST is a newly developed one-dimensional dynamic state-of-the-ground model. It calculates the ground's moisture content, ice content, temperature, and freeze-thaw profiles as well as soil strength and surface ice and snow accumulation/depletion. Because FASST is newer and not as well known, the authors wanted to determine its use as a snow model by comparing it with SNTHERM, one of the most established snow models available. It is demonstrated that even though FASST is only a single-layer snow model, the RMSE snow depth compared very favorably against SNTHERM, often performing better during the accumulation phase. The surface energy fluxes calculated by the two models were also compared and were found to be similar. C1 [Frankenstein, Susan] USA, ERDC CRREL, Hanover, NH 03755 USA. [Sawyer, Anne] NOAA NWS NOHRSC, Chanhassen, MN USA. [Koeberle, Julie] Natl Resources Conservat Serv, Snow Survey Off, USDA, Boise, ID USA. RP Frankenstein, S (reprint author), USA, ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM susan.frankenstein@erdc.usace.army.mil NR 37 TC 7 Z9 8 U1 1 U2 8 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD DEC PY 2008 VL 9 IS 6 BP 1443 EP 1463 DI 10.1175/2008JHM865.1 PG 21 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 386DD UT WOS:000261861600021 ER PT J AU Pomeroy, J Rowlands, A Hardy, J Link, T Marks, D Essery, R Sicart, JE Ellis, C AF Pomeroy, John Rowlands, Aled Hardy, Janet Link, Tim Marks, Danny Essery, Richard Sicart, Jean Emmanuel Ellis, Chad TI Spatial Variability of Shortwave Irradiance for Snowmelt in Forests SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID BOREAL FOREST; THEORETICAL ANALYSIS; COVER DEPLETION; ENERGY-BALANCE; MELT RATE; CANOPY; RADIATION; ABLATION; STANDS; MODEL AB The spatial variation of melt energy can influence snow cover depletion rates and in turn be influenced by the spatial variability of shortwave irradiance to snow. The spatial variability of shortwave irradiance during melt under uniform and discontinuous evergreen canopies at a U. S. Rocky Mountains site was measured, analyzed, and then compared to observations from mountain and boreal forests in Canada. All observations used arrays of pyranometers randomly spaced under evergreen canopies of varying structure and latitude. The spatial variability of irradiance for both overcast and clear conditions declined dramatically, as the sample averaging interval increased from minutes to 1 day. At daily averaging intervals, there was little influence of cloudiness on the variability of subcanopy irradiance; instead, it was dominated by stand structure. The spatial variability of irradiance on daily intervals was higher for the discontinuous canopies, but it did not scale reliably with canopy sky view. The spatial variation in irradiance resulted in a coefficient of variation of melt energy of 0.23 for the set of U. S. and Canadian stands. This variability in melt energy smoothed the snow-covered area depletion curve in a distributed melt simulation, thereby lengthening the duration of melt by 20%. This is consistent with observed natural snow cover depletion curves and shows that variations in melt energy and snow accumulation can influence snow-covered area depletion under forest canopies. C1 [Pomeroy, John; Ellis, Chad] Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK S7N 5CB, Canada. [Rowlands, Aled; Essery, Richard] Univ Wales, Inst Geog & Earth Sci, Aberystwyth, Ceredigion, Wales. [Hardy, Janet] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Link, Tim] Univ Idaho, Dept Forest Resources, Moscow, ID 83843 USA. [Marks, Danny] Agr Res Serv, NW Watershed Res Ctr, USDA, Boise, ID USA. [Sicart, Jean Emmanuel] Inst Rech Dev, Montpellier, France. RP Pomeroy, J (reprint author), Univ Saskatchewan, Ctr Hydrol, 117 Sci Pl, Saskatoon, SK S7N 5CB, Canada. EM john.pomeroy@usask.ca RI Link, Timothy/G-5556-2012; Pomeroy, John/A-8589-2013; OI Pomeroy, John/0000-0002-4782-7457; Essery, Richard/0000-0003-1756-9095 FU NOAA GEWEX Americas Prediction Project (GAPP); U. S. Army Corps of Engineers; Cold Regions Research and Engineering Laboratory; USDA Agricultural Research Service; Canadian Foundation for Climate and Atmospheric Sciences; Natural Sciences and Engineering Research Council of Canada FX The financial support of the NOAA GEWEX Americas Prediction Project (GAPP), U. S. Army Corps of Engineers, Cold Regions Research and Engineering Laboratory, USDA Agricultural Research Service, Canadian Foundation for Climate and Atmospheric Sciences, and the Natural Sciences and Engineering Research Council of Canada is greatly appreciated. The authors thank three anonymous reviewers and the guest editor for comments that improved this manuscript. NR 32 TC 21 Z9 22 U1 0 U2 10 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD DEC PY 2008 VL 9 IS 6 BP 1482 EP 1490 DI 10.1175/2008JHM867.1 PG 9 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 386DD UT WOS:000261861600023 ER PT J AU Krishnan, S Juang, YT Chowdhury, B Magilavy, A Fisher, CU Nguyen, H Nambiar, MP Kyttaris, V Weinstein, A Bahjat, R Pine, P Rus, V Tsokos, GC AF Krishnan, Sandeep Juang, Yuang-Taung Chowdhury, Bhabadeb Magilavy, Abigail Fisher, Carolyn U. Nguyen, Hang Nambiar, Madhusoodana P. Kyttaris, Vasileios Weinstein, Arthur Bahjat, Rena Pine, Polly Rus, Violeta Tsokos, George C. TI Differential Expression and Molecular Associations of Syk in Systemic Lupus Erythematosus T Cells SO JOURNAL OF IMMUNOLOGY LA English DT Article ID RECEPTOR ZETA-CHAIN; PROTEIN-TYROSINE KINASES; SIGNAL-TRANSDUCTION; ACTIVATION; DEFECTS; COMPLEX; VAV; AUTOIMMUNITY; INHIBITOR; DISEASE AB Diminished expression of TCR zeta and reciprocal up-regulation and association of FcR gamma with the TCR/CD3 complex is a hallmark of systemic lupus erythematosus (SLE) T cells. In this study we explored whether differential molecular associations of the spleen tyrosine kinase Syk that preferentially binds to FcR gamma contribute to pathological amplification of signals downstream of this "rewired TCR" in SLE. We detected higher amounts of Syk expression and activity in SLE compared with normal T cells. Selective inhibition of the activity of Syk reduced the strength of T CR-induced calcium responses and slowed the rapid kinetics of actin polymerization exclusively in SLE T cells. Syk and ZAP-70 also associated differently with key molecules involved in cytoskeletal and calcium signaling in SLE T cells. Thus, while Vav-1 and LAT preferentially bound to Syk, phospholipase C-gamma 1 bound to both Syk and ZAP-70. Our results show that differential associations of Syk family kinases contribute to the enhanced TCR-induced signaling responses in SLE T cells. Thus, we propose molecular targeting of Syk as a measure to control abnormal T cell responses in SLE. The Journal of Immunology, 2008, 181: 8145-8152. C1 [Tsokos, George C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Rheumatol, Boston, MA 02115 USA. [Krishnan, Sandeep; Chowdhury, Bhabadeb; Fisher, Carolyn U.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. [Nguyen, Hang] Walter Reed Army Med Ctr, Rheumatol Serv, Washington, DC 20307 USA. [Weinstein, Arthur] Washington Hosp Ctr, Rheumatol Sect, Washington, DC 20010 USA. [Bahjat, Rena; Pine, Polly] Rigel Pharmaceut, San Francisco, CA 94080 USA. [Rus, Violeta] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA. RP Tsokos, GC (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Rheumatol, Boston, MA 02115 USA. EM gtsokos@bidmic.harvard.edu FU National Institutes of Health [R01 A142269] FX This work Was Supported by National Institutes of Health Grants R01 A142269. The opinions expressed herin are the private ones of the authors and they do not represent those of the Department of Defense or the Department of the Army. NR 24 TC 58 Z9 60 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 2008 VL 181 IS 11 BP 8145 EP 8152 PG 8 WC Immunology SC Immunology GA 376YX UT WOS:000261220000080 PM 19018007 ER PT J AU Ned, RM Price, AE Crawford, SB Ayisi, JG van Eijk, AM Otieno, JA Nahlen, BL Steketee, RW Slutsker, L Shi, YP Lanar, DE Udhayakumar, V AF Ned, Renee M. Price, April E. Crawford, Sara B. Ayisi, John G. van Eijk, Anna Maria Otieno, Juliana A. Nahlen, Bernard L. Steketee, Richard W. Slutsker, Laurence Shi, Ya Ping Lanar, David E. Udhayakumar, Venkatachalam TI Effect of Placental Malaria and HIV Infection on the Antibody Responses to Plasmodium falciparum in Infants SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; IMMUNODEFICIENCY-VIRUS-INFECTION; ASYMPTOMATIC PREGNANT-WOMEN; LIVER-STAGE ANTIGEN-1; WESTERN KENYA; MATERNAL HIV; IMMUNE-RESPONSES; RISK-FACTORS; HUMORAL IMMUNITY; TRANSMISSION AB Background. Placental malaria (PM) and maternal infection with human immunodeficiency virus (HIV) type 1 have been shown to affect infant morbidity and immune responses to Plasmodium falciparum. We studied the effects of PM and HIV infection on the antimalarial antibody responses and morbidity outcomes of infants throughout the first year of life. Methods. A total of 411 Kenyan infants who were born to mothers who were singly or dually infected with PM and/or HIV had their levels of immunoglobulin G antibody to 6 P. falciparum antigens/epitopes (apical membrane antigen-1, erythrocyte-binding antigen-175; liver-stage antigen-1 [LSA-1], circumsporozoite protein [CSP], merozoite surface protein-2, and rhoptry-associated protein-1 [RAP-1]) and to tetanus toxoid (TT) tested using enzyme-linked immunosorbent assay. Results. PM had little effect on the antibody responses of infants, whereas maternal HIV infection resulted in decreased levels of antibody to LSA-1, CSP, and RAP-1 epitopes at birth, compared with the absence of PM and maternal HIV infection (P < .0063). Levels of antibodies to TT were significantly reduced in infants born to mothers coinfected with HIV and PM, compared with the levels noted in infants born to HIV-negative mothers (P < .0003). In HIV-infected infants, levels of antibody to TT were reduced, but levels of antibody to malarial antigens were not. Antimalarial antibody levels were positively associated with malaria-related morbidity outcomes. Conclusion. Infant HIV infection and maternal coinfection with HIV and PM negatively influence antibody responses to TT, but not those to malarial antigens, in infants. Antimalarial antibodies rarely showed protective associations with morbidity in infants and were more often a marker for malaria exposure and risk of infection. C1 [Ned, Renee M.; Price, April E.; Steketee, Richard W.; Slutsker, Laurence; Shi, Ya Ping; Udhayakumar, Venkatachalam] Ctr Dis Control & Prevent, Malaria Branch, Chamblee, GA 30341 USA. [Crawford, Sara B.] Ctr Dis Control & Prevent, Div Parasit Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Coordinating Ctr Infect Dis, Chamblee, GA 30341 USA. [Crawford, Sara B.] Atlanta Res & Educ Fdn, Decatur, GA USA. [Lanar, David E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Ayisi, John G.; van Eijk, Anna Maria] Kenya Govt Med Res Ctr, Kisumu, Kenya. [Otieno, Juliana A.] New Nyanza Prov Hosp, Kisumu, Kenya. [Nahlen, Bernard L.] WHO, CH-1211 Geneva, Switzerland. RP Udhayakumar, V (reprint author), Ctr Dis Control & Prevent, Malaria Branch, 4770 Buford Highway,Mail Stop F-12, Chamblee, GA 30341 USA. EM vxu0@cdc.gov RI Ned, Renee/D-3746-2009; Lanar, David/B-3560-2011 FU Atlanta Research and Educational Foundation; Centers for Disease Control and Prevention (CDC)/Division of HIV and AIDS Prevention [CDC IAA 98FED09325]; Emerging Infectious Diseases (EID) Postdoctoral Fellowship Program FX Financial support: Atlanta Research and Educational Foundation and Centers for Disease Control and Prevention (CDC)/Division of HIV and AIDS Prevention (grant CDC IAA 98FED09325). R.M.N. was supported by an appointment to the Emerging Infectious Diseases (EID) Postdoctoral Fellowship Program, and A. E. P. was supported by an appointment to the EID Training Fellowship Program; both programs were administered by the Association of Public Health Laboratories and funded by the CDC. NR 41 TC 11 Z9 11 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC 1 PY 2008 VL 198 IS 11 BP 1609 EP 1619 DI 10.1086/593066 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 374NY UT WOS:000261052200006 PM 18928377 ER PT J AU Shin, SJ Cesnik, CES Wilkie, WK Wilbur, ML AF Shin, Sang Joon Cesnik, Carlos E. S. Wilkie, W. Keats Wilbur, Matthew L. TI Design and Manufacturing of a Model-scale Active Twist Rotor Prototype Blade SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article DE active twist rotor; blade integral actuation; piezoelectric composite actuator; helicopter vibration control ID REDUCTION; BEAMS AB The design and manufacturing of an active twist rotor blade for vibration reduction in helicopters are presented. The rotor blade is integrally twisted by direct strain actuation through embedded piezoelectric fiber composite actuators distributed along the span of the blade. Highlights of the analysis formulation used to design this type of active blade are presented. The requirements for the prototype blade, along with the final design results are also presented. Detailed aspects of its manufacturing are described. Experimental structural characteristics of the prototype blade compare well with design goals, and bench actuation tests characterize its basic actuation performance. The design and manufacturing processes permit the realization of an active blade that satisfies a given set of design requirements. This is used to later develop a fully active rotor blade system. C1 [Shin, Sang Joon] Seoul Natl Univ, Inst Adv Aerosp Technol, Seoul 151742, South Korea. [Cesnik, Carlos E. S.] Univ Michigan, Dept Aerosp Engn, Ann Arbor, MI 48109 USA. [Wilkie, W. Keats] NASA, Jet Prop Lab, Mech Syst Div, Pasadena, CA 91109 USA. [Wilbur, Matthew L.] USA, Res Lab, NASA, Langley Res Ctr, Hampton, VA 23681 USA. RP Shin, SJ (reprint author), Seoul Natl Univ, Inst Adv Aerosp Technol, Seoul 151742, South Korea. EM ssjoon@snu.ac.kr FU NASA [NCC 1-323] FX The authors acknowledge the financial support and technical assistance from Mr. Paul H. Mirick (formerly U. S. Army Vehicle Technology Directorate, NASA Langley Research Center). The authors are also thankful to Dr. John P. Rodgers (Starboard Innovation Inc.) for his support to the blade fabrication, and to Mr. Gary Fleming and Ms. Emily Pryputniewics (NASA Langley's Advanced Measurement and Diagnostics Branch) for conducting the PMI tests. This work was sponsored by NASA Langley Research Center under cooperative agreement NCC 1-323. NR 38 TC 11 Z9 11 U1 0 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1045-389X J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD DEC PY 2008 VL 19 IS 12 BP 1443 EP 1456 DI 10.1177/1045389X07088051 PG 14 WC Materials Science, Multidisciplinary SC Materials Science GA 375JP UT WOS:000261110300007 ER PT J AU Lin, T Yang, Q Tan, CH Liu, B McDonald, A AF Lin, Timothy (Zhigang) Yang, Quan Tan, Chuhu Liu, Bob McDonald, Adolphus TI Processing and ballistic performance of lightweight armors based on ultra-fine-grain aluminum composites SO JOURNAL OF MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT 5th International Symposium on Ultrafine-Grained Materials CY MAR 09-13, 2008 CL New Orleans, LA ID BEHAVIOR; STRAIN; RATES AB Over last few decades, Al-based metal matrix composites (MMCs) have become a promising material of choice for lightweight armors in vehicles. Recent development in ultra-fine-grain and nanostructured material technology provides a new opportunity for the substantial strength enhancement of MMCs unattainable with the conventional microstructure of microscale, leading to significant weight reduction in armor packages. In this article, we will present the latest development of a novel class of nanostructured metal matrix composites (NMMCs) based on submicron SiC particulates reinforced nanocrystalline Al alloys. The successful fabrication of large-dimension NMMCs plates with a cost-effective synthesis and consolidation process that can be scaled up for mass production will be demonstrated. The microstructure, processing, mechanical properties, and their correlations of this class of NMMCs will also be reported. The ballistic performance of the NMMCs is investigated through a real test of high-speed machinegun bullets, and a numerical modeling as well. C1 [Lin, Timothy (Zhigang); Yang, Quan; Tan, Chuhu; Liu, Bob] Aegis Technol Inc, Santa Ana, CA 92703 USA. [McDonald, Adolphus] USA, Aviat & Missile Command, Huntsville, AL 35898 USA. RP Lin, T (reprint author), Aegis Technol Inc, 3300-A Westminster Ave, Santa Ana, CA 92703 USA. EM timlin@aegistech.net NR 9 TC 10 Z9 10 U1 1 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD DEC PY 2008 VL 43 IS 23-24 BP 7344 EP 7348 DI 10.1007/s10853-008-2977-3 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA 387LD UT WOS:000261952800015 ER PT J AU Pan, Z Guo, YZ Mathaudhu, SN Kecskes, LJ Hartwig, KT Wei, Q AF Pan, Z. Guo, Y. Z. Mathaudhu, S. N. Kecskes, L. J. Hartwig, K. T. Wei, Q. TI Quasi-static and dynamic mechanical properties of commercial-purity tungsten processed by ECAE at low temperatures SO JOURNAL OF MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT 5th International Symposium on Ultrafine-Grained Materials CY MAR 09-13, 2008 CL New Orleans, LA ID STRAIN-RATE; POLYCRYSTALLINE TUNGSTEN; ULTRAFINE GRAIN; NANOCRYSTALLINE; COMPRESSION; FAILURE; METALS AB In this work, we have processed commercial purity tungsten (W) via different routes of equal-channel angular extrusion (ECAE) at temperatures as low as 600 A degrees C. We have systematically evaluated the quasi-static and dynamic compressive behaviors of the processed W. Quasi-static compression tests were performed using an MTS hydro-servo system at room temperature. It is observed that samples ECAE processed at 800 A degrees C show higher yield and flow stresses than those processed at other temperatures; no obvious strain hardening is observed in the quasi-static stress-strain curves. Quasi-static strain rate jump tests show that the strain rate sensitivity of ECAE W is in the range of 0.02 to 0.03, smaller than that of coarse-grained W. Uni-axial dynamic compressive tests were performed using the Kolsky bar (or split-Hopkinson pressure bar, SHPB) system. Post-loading SEM observations revealed that under dynamic compression, the competition between cracking at pre-existing extrinsic surface defects, grain boundaries, and uniform plastic deformation of the individual grains control the overall plastic deformation of the ECAE W. The existence of flow softening under dynamic loading has been established for all of the ECAE W specimens. C1 [Pan, Z.; Guo, Y. Z.; Wei, Q.] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. [Mathaudhu, S. N.; Kecskes, L. J.] USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM MB, Aberdeen Proving Ground, MD 21005 USA. [Hartwig, K. T.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn & Engn Sci, 9201 Univ City Blvd, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Pan, Zhiliang/A-8061-2009; Mathaudhu, Suveen/B-4192-2009; Kecskes, Laszlo/F-6880-2014; Guo, Yazhou/E-3318-2016 OI Pan, Zhiliang/0000-0003-3899-8761; Kecskes, Laszlo/0000-0002-1342-3729; NR 19 TC 6 Z9 6 U1 1 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD DEC PY 2008 VL 43 IS 23-24 BP 7379 EP 7384 DI 10.1007/s10853-008-2788-6 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA 387LD UT WOS:000261952800021 ER PT J AU Lin, T Tan, CH Liu, B McDonald, A AF Lin, Timothy (Zhigang) Tan, Chunhu Liu, Bob McDonald, Adolphus TI Microstructure of AA2024-SiC nanostructured metal matrix composites SO JOURNAL OF MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT 5th International Symposium on Ultrafine-Grained Materials CY MAR 09-13, 2008 CL New Orleans, LA ID MECHANICAL-BEHAVIOR; ALLOYS AB Nanostructured metal matrix composites (NMMCs) in large-dimension billets were fabricated by hot isostatic pressing (HIPing) of cryomilled powders consisting of AA2024 alloy reinforced by 25 wt.% SiC particles. Microstructure of the bulk nanostructured composites and cryomilled powders was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). In addition, mechanical properties of the bulk nanocomposites were also addressed. C1 [Lin, Timothy (Zhigang); Tan, Chunhu; Liu, Bob] Aegis Technol Inc, Santa Ana, CA 92703 USA. [McDonald, Adolphus] USA, Aviat & Missile Command, Redstone Arsenal, AL 35898 USA. RP Lin, T (reprint author), Aegis Technol Inc, 3300 A Westminster Ave, Santa Ana, CA 92703 USA. EM timlin@aegistech.net NR 9 TC 2 Z9 2 U1 1 U2 4 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD DEC PY 2008 VL 43 IS 23-24 BP 7507 EP 7512 DI 10.1007/s10853-008-2726-7 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA 387LD UT WOS:000261952800040 ER PT J AU Wallace, SM Szabo, KA Schlabritz-Loutsevitch, NE Dick, EJ Blanchard, TW Hubbard, GB AF Wallace, Shannon M. Szabo, Kathleen A. Schlabritz-Loutsevitch, Natalia E. Dick, Edward J. Blanchard, Terrell W. Hubbard, Gene B. TI Myxomatous neoplasms in the perineal region of baboons SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE Aggressive angiomyxoma; angiomyofibroblastoma; cdk4; estrogen receptor; MDM2; progesterone receptor ID FEMALE GENITAL-TRACT; AGGRESSIVE ANGIOMYXOMA; ANGIOMYOFIBROBLASTOMA; EXPRESSION; VULVA; COW AB Background In baboons, Papio sp. neoplasms tend to affect the hematopoietic system most commonly, with rare documentation of myxomatous neoplasms. In contrast, women can develop myxomatous masses within deep peripelvic tissues with some frequency during their reproductive years. Methods We have identified and examined, retrospectively, myxomatous perineal masses in twelve female baboons within one research facility and compared their histopathologic, immunohistochemical and electron microscopic features to their human variants. Results Our results indicate that these myxomatous neoplasms, in humans and non-human primates, share common features. Conclusion Further research, particularly molecular genetic analysis, may be needed to identify the baboon as a true animal model for myxomatous perineal neoplasms. C1 [Wallace, Shannon M.; Szabo, Kathleen A.] Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD 20910 USA. [Schlabritz-Loutsevitch, Natalia E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Blanchard, Terrell W.] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Dick, Edward J.; Hubbard, Gene B.] SW Fdn Biomed Res, SW Natl Primate Res Ctr, San Antonio, TX 78284 USA. RP Wallace, SM (reprint author), Walter Reed Army Inst Res, Dept Pathol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM shannon.m.wallace@us.army.mil FU NCRR NIH HHS [P51 RR013986] NR 33 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0047-2565 J9 J MED PRIMATOL JI J. Med. Primatol. PD DEC PY 2008 VL 37 IS 6 BP 261 EP 270 DI 10.1111/j.1600-0684.2008.00293.x PG 10 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 367FW UT WOS:000260538900001 PM 19017193 ER PT J AU Thatch, KA Schwartz, MZ Yoo, EY Mendelson, KG Duke, DS AF Thatch, Keith A. Schwartz, Marshall Z. Yoo, Edward Y. Mendelson, Kim G. Duke, Duane S. TI Modulation of the inflammatory response and apoptosis using epidermal growth factor and hepatocyte growth factor in a liver injury model: a potential approach to the management and treatment of cholestatic liver disease SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article; Proceedings Paper CT 41st Annual Meeting of the Pacific-Association-of-Pediatric-Surgeons CY JUN 29-JUL 03, 2008 CL Grand Teton Natl Pk, WY SP Pacific Assoc Pediat Surg DE Short bowel syndrome; TPN; Liver injury; Liver disease; alpha-Naphtylisocyocyanate; Hepatocyte growth factor; Epithelial growth factor ID TOTAL PARENTERAL-NUTRITION; SHORT-BOWEL SYNDROME; INTESTINAL ADAPTATION; REGENERATION; PREVENTION; GLUCAGON; CHILDREN; RECEPTOR; FAILURE; RATS AB Background/Purpose: The major side effect of total parenteral nutrition is liver injury leading to liver failure. This Study was designed to assess specific growth factors in modulating the hepatic response in an ANIT-induced liver-injury model. Methods: Sprague-Dawley rats were divided into four groups: control (n = 5), liver-injury control (alpha-naphtylisocyocyanate [ANIT], 100 mg/kg, n = 8), ANIT + epidermal growth factor(EGF, 150 mu g/kg per (Jay, n = 10), and ANIT + hepatocyte growth factor (HGF, 250 mu g/kg per clay, n = 9). Rats were given intraperitoneal injections of saline (control) or ANIT and implantation of an osmotic mini-pump for 7 days of continuous intravenous Saline (liver injury control), EGF, or FIGF. Seven and 14 days later, liver biopsies were obtained and evaluated for interleukin (IL)-6 and tumor necrosis factor a expression by immunofluorescent staining, and for apoptosis, by the terminal transferase dUTP nick end labeling (TUNEL) technique. All animals were euthanized at 14 clays. Results: Epidermal growth factor (P < .025) and HGF (P < .001) groups induced less IL-6 expression at day 14 compared to liver-injury controls. In addition, the interval decrease in IL-6 expression between days 7 and 14 was greater in EGF (P < .001) and HGF (P <.001) groups compared to liver-injury controls. At clay 14, FIGF also demonstrated decreased tumor necrosis factor cl expression (P <.005). Apoptotic activity was significantly less for the EGF (P < .011) and HGF (P < .0012) groups. Conclusion: Epidermal growth factor and HGF modulated the hepatic inflammatory response and apoptotic index in this established liver-injury model and may diminish or prevent liver damage in patients with total parenteral nutrition-induced liver injury. (C) 2009 Published by Elsevier Inc. C1 [Thatch, Keith A.; Schwartz, Marshall Z.; Yoo, Edward Y.; Mendelson, Kim G.] St Christophers Hosp Children, Philadelphia, PA 19134 USA. [Thatch, Keith A.; Schwartz, Marshall Z.; Yoo, Edward Y.; Mendelson, Kim G.] Drexel Univ, Coll Med, Philadelphia, PA 19102 USA. [Duke, Duane S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Schwartz, MZ (reprint author), St Christophers Hosp Children, Philadelphia, PA 19134 USA. EM mzschwartz@msn.com NR 25 TC 11 Z9 12 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD DEC PY 2008 VL 43 IS 12 BP 2169 EP 2173 DI 10.1016/j.jpedsurg.2008.08.045 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA 386AC UT WOS:000261853700007 PM 19040928 ER PT J AU Resio, DT Perrie, W AF Resio, Donald T. Perrie, William TI A Two-Scale Approximation for Efficient Representation of Nonlinear Energy Transfers in a Wind Wave Spectrum. Part I: Theoretical Development SO JOURNAL OF PHYSICAL OCEANOGRAPHY LA English DT Article ID FINITE DEPTH WATER; EQUILIBRIUM RANGE; GENERATED WAVES; GRAVITY-WAVES; MODEL; PARAMETERIZATIONS; COMPUTATIONS; SIMILARITY; PREDICTION AB A new method for estimating the transfer rates in wind wave spectra is derived and tested, based on a two-scale approximation (TSA) to the total integral for quadruplet wave-wave interactions. Comparisons of this new estimation method to the full integral are given for several idealized spectra, including Joint North Sea Wave Project spectra with different peakednesses, a finite depth case, and cases with perturbations added to underlying parametric spectra. In particular, these comparisons show that the TSA is a significant improvement over the discrete interaction approximation (DIA) in deep water and an even greater improvement in shallow water. C1 [Perrie, William] Fisheries & Oceans Canada, Bedford Inst Oceanog, Dartmouth, NS BZY 4AZ, Canada. [Resio, Donald T.] ERDC Coastal & Hydraul Lab, Vicksburg, MS USA. RP Perrie, W (reprint author), Fisheries & Oceans Canada, Bedford Inst Oceanog, Dartmouth, NS BZY 4AZ, Canada. EM perriew@dfo-mpo.gc.ca FU U.S. Army Corps of Engineers MORPHOS; Canadian Panel on Energy Research and Development; ONR (U. S. Office of Naval Research) through the Gulf of Maine Ocean Observing System (GoMOOS); Southeast University Research Association Coastal Ocean Observing and Prediction (SCOOP); Canada Foundation for Climate and Atmospheric Studies FX The authors would like to acknowledge the valuable contributions of the anonymous reviewers to this paper. Their detailed reviews greatly improved both the content and accuracy of this manuscript. Support for this research comes from the U.S. Army Corps of Engineers MORPHOS program, the Canadian Panel on Energy Research and Development (PERD-Offshore Environmental Factors Program), ONR (U. S. Office of Naval Research) through the Gulf of Maine Ocean Observing System (GoMOOS), the Southeast University Research Association Coastal Ocean Observing and Prediction (SCOOP) program, and the Canada Foundation for Climate and Atmospheric Studies. The authors also wish to acknowledge the Office, Chief of Engineers, U. S. Army Corps of Engineers for permission to publish this paper. NR 32 TC 14 Z9 14 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0022-3670 J9 J PHYS OCEANOGR JI J. Phys. Oceanogr. PD DEC PY 2008 VL 38 IS 12 BP 2801 EP 2816 DI 10.1175/2008JPO3713.1 PG 16 WC Oceanography SC Oceanography GA 386ZJ UT WOS:000261921200012 ER PT J AU Zhang, X Mi, CC Masrur, A Daniszewski, D AF Zhang, Xi Mi, Chris Chunting Masrur, Abul Daniszewski, David TI Wavelet-transform-based power management of hybrid vehicles with multiple on-board energy sources including fuel cell, battery and ultracapacitor SO JOURNAL OF POWER SOURCES LA English DT Article DE Hybrid electric vehicle; Wavelet transform; Wavelet decomposition; Power management; Power demand; Powerflow ID LITHIUM-ION BATTERY; ELECTRIC VEHICLES; HAAR WAVELET; MODEL; SYSTEM; SUPERCAPACITOR; SIMULATION AB A wavelet-transform-based strategy is proposed for the power management of hybrid electric vehicles (HEV) with multiple on-board energy sources and energy storage systems including a battery, a fuel cell, and an ultra-capacitor. The proposed wavelet-transform algorithm is capable of identifying the high-frequency transient and real time power demand of the HEV, and allocating power components with different frequency contents to corresponding sources to achieve an optimal power management control algorithm. By using the wavelet decomposition algorithm, a proper combination can be achieved with a properly sized Ultra-capacitor dealing with the chaotic high-frequency components of the total power demand, while the fuel cell and battery deal with the low and medium frequency power demand. Thus the system efficiency and life expectancy can be greatly extended. Simulation and experimental results validated the effectiveness of wavelet-transform-based power management algorithm. (C) 2008 Elsevier B.V. All rights reserved. C1 [Zhang, Xi; Mi, Chris Chunting] Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. [Masrur, Abul; Daniszewski, David] USA, RDECOM TARDEC, Warren, MI USA. RP Mi, CC (reprint author), Univ Michigan, Dept Elect & Comp Engn, 4901 Evergreen Rd, Dearborn, MI 48128 USA. EM chrismi@umich.edu RI Mi, Chunting/E-3769-2013 OI Mi, Chunting/0000-0002-5471-8953 NR 28 TC 57 Z9 59 U1 5 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD DEC 1 PY 2008 VL 185 IS 2 BP 1533 EP 1543 DI 10.1016/j.jpowsour.2008.08.046 PG 11 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 384MM UT WOS:000261748900138 ER PT J AU Rupp, TL Macauslan, J Boyce, S Balkin, TJ AF Rupp, T. L. Macauslan, J. Boyce, S. Balkin, T. J. TI Speech degradation with sleep restriction and recovery SO JOURNAL OF SLEEP RESEARCH LA English DT Meeting Abstract CT 19th Congress of the European-Sleep-Research-Society CY SEP 09-13, 2008 CL Glasgow, SCOTLAND SP European Sleep Res Soc C1 [Rupp, T. L.; Balkin, T. J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Macauslan, J.; Boyce, S.] STAR Analyt Serv, Bedford, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD DEC PY 2008 VL 17 BP 226 EP 226 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 400EH UT WOS:000262850300637 ER PT J AU Jernajczyk, W Ignaccolo, M Latka, M West, BJ AF Jernajczyk, W. Ignaccolo, M. Latka, M. West, B. J. TI Diffusion entropy analysis of sleep EEG SO JOURNAL OF SLEEP RESEARCH LA English DT Meeting Abstract CT 19th Congress of the European-Sleep-Research-Society CY SEP 09-13, 2008 CL Glasgow, SCOTLAND SP European Sleep Res Soc C1 [Jernajczyk, W.] Inst Psychiat & Neurol, Dept Clin Neurophysiol, Warsaw, Poland. [Ignaccolo, M.] Duke Univ, Durham, NC USA. [Latka, M.] Wroclaw Univ Technol, PL-50370 Wroclaw, Poland. [West, B. J.] USA, Res Off, Math & Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD DEC PY 2008 VL 17 BP 229 EP 229 PG 1 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 400EH UT WOS:000262850300647 ER PT J AU Yasuda, T Brechue, WF Fujita, T Sato, Y Abe, T AF Yasuda, Tomohiro Brechue, William F. Fujita, Taku Sato, Yoshiaki Abe, Takashi TI Muscle activation during low-intensity muscle contractions with varying levels of external limb compression SO JOURNAL OF SPORTS SCIENCE AND MEDICINE LA English DT Article DE Neuromuscular function; EMG; cuff pressure; biceps brachii; ischemia ID MODERATE VASCULAR OCCLUSION; RESISTANCE EXERCISE; BLOOD-FLOW; MUSCULAR FUNCTION; FATIGUE; RESTRICTION; RESPONSES; STRENGTH; HORMONE; HUMANS AB The purpose was to investigate muscle activation during low-intensity muscle contractions with various levels of external limb compression to reduce muscle perfusion/outflow. A series of unilateral elbow flexion muscle contractions (30 repetitive contractions followed by 3 sets x 15 contractions) was performed at 20% of 1RM with varying levels of external compression (0 (without compression), 98, 121, and 147 mmHg external compression) around the upper arm. Electromyography (EMG) signals were recorded from surface electrodes placed on the biceps brachii muscle and analyzed for integrated EMG (iEMG). Maximal voluntary isometric contraction (MVC) decreased similarly during the control (0 mmHg) and 98 mmHg external compression bout (similar to 18%); the decline in MVC with 121 and 147 mmHg external compression was significantly greater (similar to 37%). Muscle activation increased progressively throughout the contraction bout with each level of external compression, but iEMG was significantly greater during 147 mmHg external compression. In conclusion, low-intensity muscle contractions performed with external compression of 147 mmHg appears to alter muscle perfusion/outflow leading to increased muscle activation without decrements in work performed during the contraction bout. C1 [Yasuda, Tomohiro] Univ Tokyo, Grad Sch Med, Dept Ischem Circulatory Physiol, Bunkyo Ku, Tokyo 1138655, Japan. [Yasuda, Tomohiro; Fujita, Taku] Tokyo Metropolitan Univ, Grad Sch Sci, Dept Exercise & Sport Sci, Tokyo 158, Japan. [Brechue, William F.] US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA. [Abe, Takashi] Univ Tokyo, Grad Sch Frontier Sci, Inst Environm Studies, Chiba, Japan. RP Yasuda, T (reprint author), Univ Tokyo, Grad Sch Med, Dept Ischem Circulatory Physiol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan. EM yasuda-tomohiro@umin.ac.jp; bill.brechue@usma.edu; fujitaku_high_low@hotmail.co.jp; info@satosports.co.jp; abe@k.u-tokyo.ac.jp FU Japan Ministry of Education, Culture, Sports, Science, and Technology [15300221 from the] FX The authors thank the students who participated in this study. We also thank Dr. Toshiaki Nakajima, Dr. Satoshi Fujita, and Miwa Kurano (The University of Tokyo) for helpful discussion. This study was supported by Grant-in-aid 15300221 from the Japan Ministry of Education, Culture, Sports, Science, and Technology. NR 27 TC 21 Z9 21 U1 2 U2 10 PU JOURNAL SPORTS SCIENCE & MEDICINE PI BURSA PA MEDICAL FACULTY ULUDAG UNIV, DEPT SPORTS MEDICINE, BURSA, 16059, TURKEY SN 1303-2968 J9 J SPORT SCI MED JI J. Sport. Sci. Med. PD DEC PY 2008 VL 7 IS 4 BP 467 EP 474 PG 8 WC Sport Sciences SC Sport Sciences GA 403IX UT WOS:000263077400007 PM 24149952 ER PT J AU Ostashev, VE Scanlon, MV Wilson, DK Vecherin, SN AF Ostashev, Vladimir E. Scanlon, Michael V. Wilson, D. Keith Vecherin, Sergey N. TI Source localization from an elevated acoustic sensor array in a refractive atmosphere SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article AB Localization of sound sources on the ground from an acoustic sensor array elevated on a tethered aerostat is considered. To improve estimation of the source coordinates, one should take into account refraction of sound rays due to atmospheric stratification. Using a geometrical acoustics approximation for a stratified moving medium, formulas for the source coordinates are derived that account for sound refraction. The source coordinates are expressed in terms of the direction of sound propagation as measured by the sensor array, its coordinates, and the vertical profiles of temperature and wind velocity. Employing these formulas and typical temperature and wind velocity profiles in the atmosphere, it is shown numerically that sound refraction is important for accurate predictions of the source coordinates. Furthermore, it is shown that the effective sound speed approximation, which is widely used in atmospheric acoustics, fails to correctly predict the source coordinates if the grazing angle of sound propagation is relatively large. (C) 2008 Acoustical Society of America. [DOI: 10.1121/1.3003085] C1 [Ostashev, Vladimir E.] NOAA, Earth Syst Res Lab, Boulder, CO 80303 USA. [Scanlon, Michael V.] USA, Res Lab, AMSRD ARL SE SP, Adelphi, MD 20783 USA. [Wilson, D. Keith] USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Vecherin, Sergey N.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. RP Ostashev, VE (reprint author), NOAA, Earth Syst Res Lab, Boulder, CO 80303 USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU Army Research Laboratory [W911NF-06-2-0015] FX This research was supported by the Army Research Laboratory via a subagreement with the DoD Center for Geosciences/Atmospheric Research at Colorado State University under Cooperative Agreement W911NF-06-2-0015. NR 10 TC 11 Z9 11 U1 0 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD DEC PY 2008 VL 124 IS 6 BP 3413 EP 3420 DI 10.1121/1.3003085 PG 8 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 398XS UT WOS:000262765600008 PM 19206770 ER PT J AU Vertrees, A Greer, L Pickett, C Nelson, J Wakefield, M Stojadinovic, A Shriver, C AF Vertrees, Amy Greer, Lauren Pickett, Chris Nelson, Jeffery Wakefield, Matthew Stojadinovic, Alexander Shriver, Craig TI Modern Management of Complex Open Abdominal Wounds of War: A 5-Year Experience SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article; Proceedings Paper CT 93rd Annual Clinical Congress of the American-College-of-Surgeons CY OCT 07-11, 2007 CL New Orleans, LA SP Amer Coll Surg ID ACELLULAR DERMAL MATRIX; DAMAGE CONTROL; OPEN ABDOMEN; VENTRAL HERNIA; CLOSURE; MILITARY; IRAQ AB BACKGROUND: Optimal management of the open abdomen remains controversial. STUDY DESIGN: Retrospective review of patients injured during Operations Enduring Freedom and Iraqi Freedom returning to Walter Reed Army Medical Center (WRAMC) from January 2003 to October 2007 for treatment of open abdomen. RESULTS: Three hundred fifty-four patients were evacuated to WRAMC after laparotomy, including 86 patients (24%) with open abdomen. Three transferred patients were excluded. Eighty-three patients, mean age 26 years (range 18 to 54 years), sustaining injury from secondary blast (n = 47), gunshot (n = 29), and blunt trauma (n = 7) were studied. Surgical management included early definitive abdominal closure (EDAC, n = 56; 67%), primary fascial closure (n = 15; 18%), planned ventral hernia (PVH, n = 9; 11 %) and vacuum-assisted closure with AlloDerm (n = 3; 4%). EDAC closure involves serial closure with Gore-Tex Dualmesh and final closure supplemented with polypropylene mesh (62%) or AlloDerm (31%). There was no substantial difference in injury mechanism, age, length of evacuation to WRAMC, or Injury Severity Score (average 30) according to closure type. Complications included removal of infected prosthetic mesh in 4 EDAC closure patients (5%). Overall morbidity was lowest (60%) in primary repair patients (p = 0.01). Rates of deep venous thrombosis, pulmonary embolism, abdominal wall hematoma, and infection did not differ between groups. Fistula rate was increased with PVH (20%). Two patients with PVH died. PVH and EDAC mesh complications have been minimized in the last 2 years of the study. CONCLUSIONS: Primary closure of fascia is ideal but not always possible. Early definitive closure has avoided PVH. Mesh-related complications have decreased with time. (J Am Coll Surg 2008;207:801-809. (C) 2008 by the American College of Surgeons) C1 [Vertrees, Amy; Greer, Lauren; Pickett, Chris; Nelson, Jeffery; Wakefield, Matthew; Stojadinovic, Alexander; Shriver, Craig] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Vertrees, A (reprint author), Walter Reed Army Med Ctr, Bldg 2,5th Floor,6900 Georgia Ave NW, Washington, DC 20307 USA. EM amy.vertrees@amedd.army.mil NR 16 TC 40 Z9 42 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD DEC PY 2008 VL 207 IS 6 BP 801 EP 809 DI 10.1016/j.jamcollsurg.2008.08.014 PG 9 WC Surgery SC Surgery GA 382GE UT WOS:000261592800002 PM 19183525 ER PT J AU Turell, MJ Dohm, DJ Mores, CN Terracina, L Wallette, DL Hribar, LJ Pecor, JE Blow, JA AF Turell, Michael J. Dohm, David J. Mores, Christopher N. Terracina, Lucas Wallette, Dennis L., Jr. Hribar, Lawrence J. Pecor, James E. Blow, Jamie A. TI POTENTIAL FOR NORTH AMERICAN MOSQUITOES TO TRANSMIT RIFT VALLEY FEVER VIRUS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Rift Valley fever; vector; transmission; North America ID VECTOR COMPETENCE; CULEX-PIPIENS; SAUDI-ARABIA; PHLEBOTOMUS-DUBOSCQI; SOUTH-AFRICA; SAND FLY; EPIDEMIC; DIPTERA; EGYPT; DISSEMINATION AB The rapid spread of West Nile viral activity across North America since its discovery in 1999 illustrates the potential for an exotic arbovirus to be introduced and widely established across North America. Rift Valley fever virus (RVFV) has been responsible for large outbreaks in Africa that have resulted in hundreds of thousands of human infections and major economic disrubpiton due to loss of livestock and to trade restrictions. However, little is known about the potential for North American mosquitoes to transmit this virus should it be introduced into North America. Therefore, we evaluated selected mosquito species from the southeastern United States for their ability to serve as potential vectors for RVFV. Mosquitoes were fed on adult hamsters inoculated 1 day previously with RVFV. These mosquitoes were tested for infection and ability to transmit RVFV after incubation at 26 degrees C for 7-21 days. None of the species tested (Aedes taeniorhynchus. Ae. vexans. Culex erraticus. Cx. nigripalpus, Cx. quinquefasciatus, and Cx. Salinarius) were efficient vectors after they fed on hamsters with viremias ranging from 10(4.1) to 10(6.9) plaque-forming units (PFU)/ml. However, Ae, taeniorhynchus, Ae, vexans, and Cx, erraticus all developed disseminated infections after they fed on hamsters with viremias between 10(8.5) and 10(10.2) PFU/ml, and both Ae, vexans and Cx, erraticus transmitted RVFV by bite. These studies illustrate the need to identify the ability of individual mosquito species to transmit RVFV so that appropriate decisions can be made concerning the application of control measures during an outbreak. C1 [Turell, Michael J.; Dohm, David J.; Mores, Christopher N.; Blow, Jamie A.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Terracina, Lucas] Calcasieu Parish Police Jury, Dept Mosquito & Rodent Control, Lake Charles, LA 70615 USA. [Wallette, Dennis L., Jr.] Tangipahoa Mosquito Abatement Dist, Hammond, LA 70403 USA. [Hribar, Lawrence J.] Florida Keys Mosquito Control Dist, Marathon, FL 33050 USA. [Pecor, James E.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20907 USA. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. FU National Biodefense Analysis and Countermeasures Center [04-0-DI-1009] FX This work was supported by a g-rant (04-0-DI-1009) from the National Biodefense Analysis and Countermeasures Center. NR 35 TC 62 Z9 65 U1 0 U2 8 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2008 VL 24 IS 4 BP 502 EP 507 DI 10.2987/08-5791.1 PG 6 WC Entomology SC Entomology GA 388GJ UT WOS:000262008000005 PM 19181056 ER PT J AU Klun, JA Kramer, M Zhang, AJ Wang, SF Debboun, M AF Klun, Jerome A. Kramer, Matthew Zhang, Aijun Wang, Shifa Debboun, Mustapha TI A QUANTITATIVE IN VITRO ASSAY FOR CHEMICAL MOSQUITO-DETERRENT ACTIVITY WITHOUT HUMAN BLOOD CELLS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes aegypti; Anopheles stephensi; N,N-diethyl-3-methylbenzamide; ATP; mosquito biting; isolongifolenone; CPDA-1 ID AEDES-AEGYPTI; CALLICARPA-AMERICANA; ATP; PHAGOSTIMULANTS; CULICIDAE AB We report that an aqueous solution containing 10(-3) M adenosine triphosphate (ATP) and citrate-phosphate-dextrose-adenine (CPDA-1) can effectively replace transfusable human red blood cells in an in vitro Klun and DEbboun bioassay system for evaluating chemicals for mosquito feeding-deterrent activity, using either Aedes aegypti or Anopoheles stephensi. These species fed with similar avidity through collagen membrane covering aqueous 10(-3) M ATP plus CPDA-1 or red blood cells in CPDA-1 supplemented with ATP. In a 2nd experiment, we evaluated the feeding-deterrent activity of N,N-diethyl-3-methylbenzamide and a newly discovered natural product chemical, (-)-isolongifolenone, against these 2 mosquito species. We found that the feeding-deterrent efficacy of the 2 chemicals was similar whether the feeding stimulant was red blood cells supplemented with ATP or ATP alone with CPDA-1. Since the use of human red blood cells in bioassays raises important health and logistic issues, aqueous ATP with CPDA-1 is a reasonable alternative to human blood cells for routine in vitoro chemical screening. C1 [Klun, Jerome A.; Zhang, Aijun] ARS, USDA, Insect Biocontrol & Behav Lab, Beltsville, MD 20705 USA. [Kramer, Matthew] ARS, USDA, Biometr Consulting Serv, Beltsville, MD 20705 USA. [Wang, Shifa] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China. [Debboun, Mustapha] USA, Med Dept Ctr & Sch, Acad Hlth Sci, Dept Prevent Hlth Serv,Med Zool Branch, Ft Sam Houston, TX 78234 USA. RP Klun, JA (reprint author), ARS, USDA, Insect Biocontrol & Behav Lab, Beltsville, MD 20705 USA. NR 18 TC 15 Z9 15 U1 1 U2 7 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2008 VL 24 IS 4 BP 508 EP 512 DI 10.2987/08-5755.1 PG 5 WC Entomology SC Entomology GA 388GJ UT WOS:000262008000006 PM 19181057 ER PT J AU Hughes, TH Irwin, PM Kaufman, A Sage, H Pagac, BB Paskewitz, SM AF Hughes, Tony H. Irwin, Patrick M. Kaufman, Andrew Sage, Heather Pagac, Benedict B., Jr. Paskewitz, Susan M. TI FIRST RECORDS OF AEDES JAPONICUS JAPONICUS IN WISCONSIN SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes japonicus japonicus; first record; human landing catch; vector ID LA-CROSSE VIRUS; OCHLEROTATUS-JAPONICUS; CULICIDAE; DIPTERA; MOSQUITOS; THEOBALD AB Aedes japonicus japonicus was collected via gravid trapping in Wisconsin in the summers of 2004 and 2005 at Fort McCoy, Monroe County, Subsequently, in summer of 2007, Ae. japonicus was captured in a human landing catch in Dane County, Madison, WI. Additional collections were made at this site in the spring of 2008. Invasion is in progress, but significant population increases have not yet been confirmed. C1 [Hughes, Tony H.; Irwin, Patrick M.; Kaufman, Andrew; Sage, Heather; Paskewitz, Susan M.] Univ Wisconsin, Dept Entomol, Madison, WI 53706 USA. [Pagac, Benedict B., Jr.] USA, Entomol Sci Div, Ctr Hlth Promot & Prevent Med N, Ft George G Meade, MD 20755 USA. RP Paskewitz, SM (reprint author), Univ Wisconsin, Dept Entomol, 237 Russell Labs,1630 Linden Dr, Madison, WI 53706 USA. NR 14 TC 12 Z9 12 U1 3 U2 4 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2008 VL 24 IS 4 BP 583 EP 584 DI 10.2987/5735.1 PG 2 WC Entomology SC Entomology GA 388GJ UT WOS:000262008000017 PM 19181068 ER PT J AU Weiss, BM Shumway, NM Howard, RS Ketchum, LK Reid, TJ AF Weiss, Brendan M. Shumway, Nathan M. Howard, Robin S. Ketchum, Lloyd K. Reid, Thomas J. TI Optical density values correlate with the clinical probability of heparin induced thrombocytopenia SO JOURNAL OF THROMBOSIS AND THROMBOLYSIS LA English DT Article; Proceedings Paper CT 2nd Annual Meeting of the International-Society-of-the-Cardiovascular-Translational-Research CY FEB 27-28, 2009 CL San Diego, CA SP Int Soc Cardiovasc Translat Res, Catholic Healthcare W DE Heparin-induced thrombocytopenia; Enzyme linked immunosorbent assay; Predictive value of tests ID D-DIMER; DIAGNOSIS; ANTIBODIES; MANAGEMENT; THROMBOSIS; SCORE AB Introduction Heparin induced thrombocytopenia is a clinicopathologic syndrome that may result in severe thrombotic sequelae without prompt diagnosis and treatment. A clinical scoring system to assess the pre-test probability of heparin-induced thrombocytopenia, the 4 T's, has been reported to correlate with the serotonin release assay. Materials and methods We performed a single-center, retrospective study correlating the 4 T's score with the commercial heparin-PF4 ELISA. Results One hundred forty four cases were identified. The pre-test probability scores were: low probability 45.8%, moderate probability 41.0% and high probability 13.2%. The median optical density was 0.148, 0.223 and 0.470 for low probability, moderate probability and high probability, respectively (P < 0.0005). The frequencies of obtaining an optical density > 1.00 for these probability scores were 1.5%, 6.8%, and 36.8%, respectively (P < 0.0005). Conclusions Heparin-PF4 ELISA optical density values increase with increasing probability of heparin induced thrombocytopenia. C1 [Weiss, Brendan M.; Shumway, Nathan M.; Howard, Robin S.; Ketchum, Lloyd K.; Reid, Thomas J.] Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA. RP Weiss, BM (reprint author), Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM brendan.weiss@us.army.mil NR 12 TC 16 Z9 17 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0929-5305 J9 J THROMB THROMBOLYS JI J. Thromb. Thrombolysis PD DEC PY 2008 VL 26 IS 3 BP 243 EP 247 DI 10.1007/s11239-007-0162-1 PG 5 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 371NQ UT WOS:000260838400011 PM 17982734 ER PT J AU Sidawy, AN Aidinian, G Johnson, ON White, PW DeZee, KJ Henderson, WG AF Sidawy, Anton N. Aidinian, Gilbert Johnson, Owen N., III White, Paul W. DeZee, Kent J. Henderson, William G. TI Effect of chronic renal insufficiency on outcomes of carotid endarterectomy SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 21st Annual Meeting of the Eastern-Vascular-Society CY SEP 27-29, 2007 CL Baltimore, MD SP Eastern Vasc Soc ID GLOMERULAR-FILTRATION-RATE; CHRONIC KIDNEY-DISEASE; HIGH-RISK; SERUM CREATININE; SYMPTOMATIC PATIENTS; MORTALITY; STENOSIS; DYSFUNCTION; PROTOCOLS; TRIAL AB Objective: Conflicting data exist regarding the effect of chronic renal insufficiency (CRI) on carotid endarterectomy (CEA) outcomes. A large database was used to analyze the effect of CRI, defined by glomerular filtration rate (GFR), as an independent risk factor of CEA. Methods: Prospectively collected data regarding CEAs performed at 123 Veterans Affairs Medical Centers as part of the National Surgical Quality Improvement Program were retrospectively analyzed. Renal function was used to divide patients into three CRI groups: normal or mild (control; GFR >= 60 mL/min/1.73 m(2)), moderate (GFR 30 to 59), and severe (GFR <30). Bivariate analysis and multivariate logistic regression were used to characterize risk factors and their associations with 30-day morbidity and mortality. Results: Between Jan 1, 1996, and Dec 31, 2003, 22,080 patients underwent CEA. Patients missing creatinine levels, already dialysis-dependent, or in acute renal failure just before surgery were excluded. This left 20,899 available for analysis, of which 13,965 had a GFR of >= 60, 6,423 had a GFR of 30 to 59, and 511 had a GFR of <30. The incidence of neurologic complications did not differ significantly (control, 1.7%; moderate CRI, 1.9%; severe CRI, 2.7%). The moderate CRI group experienced significantly more cardiac events (1.7% vs 0.9% for controls, P < .001). This remained predictive in the multivariate model even adjusting for all other risk factors (adjusted odds ratio [AOR], 1.6; 95% confidence interval [CI] 1.1-2.3; P = .009). The moderate CRI group also had higher rates of pulmonary complications (2.1% vs 1.3% control; P < .001; AOR, 1.3; 95% CI, 1.0-1.7; P = .031) but not 30-day mortality (P = .269). Those with severe CRI had a much higher mortality (3.1% vs 1.0% control, P < .001), which remained significant in the multivariate model (AOF, 2.7; 95% CI, 1.6-4.8; P < .001). Conclusion: Although impaired renal function does not independently increase the risk of neurologic or infections complications, CRI is a significant negative independent risk factor in predicting other outcomes after CEA. Patients with moderate CRI (GFR, 30-59 mL/min/1.73 m(2)) are at increased risk for cardiac and pulmonary morbidity, but not death, and those with severe CRI (GFR <30 mL/min/1.73 m(2)) have a much higher operative mortality. Patients with CRI should be carefully evaluated before CEA to optimize existing cardiac and pulmonary disease. Understanding this increased risk may assist the surgeon in preoperative counseling and perioperative management. (J Vasc Surg 2008;48:1423-30.) C1 [Sidawy, Anton N.] George Washington Univ, Dept Surg, Washington, DC USA. [Sidawy, Anton N.; Aidinian, Gilbert; Johnson, Owen N., III; White, Paul W.] Vet Affairs Med Ctr, Surg Serv, Washington, DC 20422 USA. [Sidawy, Anton N.; Henderson, William G.] Georgetown Univ, Washington, DC 20057 USA. [Aidinian, Gilbert; Johnson, Owen N., III; White, Paul W.; DeZee, Kent J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Sidawy, Anton N.; Henderson, William G.] Univ Colorado, Hlth Outcomes Program, Denver, CO 80202 USA. RP Sidawy, AN (reprint author), 50 Irving St,NW 112, Washington, DC 20422 USA. EM ansidawy@aol.com OI Johnson III, Owen/0000-0001-6497-1285 NR 32 TC 33 Z9 34 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD DEC PY 2008 VL 48 IS 6 BP 1423 EP 1430 DI 10.1016/j.jvs.2008.07.006 PG 8 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 388FX UT WOS:000262006800011 PM 18829214 ER PT J AU O'Guinn, ML Klein, TA Lee, JS Kim, HC Baek, LJ Chong, ST Turell, MJ Burkett, DA Schuster, A Lee, IY Yi, SH Sames, WJ Song, KJ Song, FW AF O'Guinn, Monica L. Klein, Terry A. Lee, John S. Kim, Heung-Chul Baek, Luck-Ju Chong, Sung-Tae Turell, Michael J. Burkett, Douglas A. Schuster, Anthony Lee, In-Yong Yi, Suk-Hee Sames, William J. Song, Ki-Joon Song, Fin-Won TI Ecological surveillance of small mammals at Firing Points 10 and 60, Gyeonggi Province, Republic of Korea, 2001-2005 SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Rodents; insectivores; ecology; Korea; Apodemus; Rattus; Micromys; Microtus; Myodes (= Eothenomys); Tscherskia (= Cricetulus) ID SIN-NOMBRE-VIRUS; APODEMUS-AGRARIUS; RODENT POPULATIONS; HEMORRHAGIC-FEVER; ETIOLOGIC AGENT; SOUTH-KOREA; INFECTION; TRANSMISSION; SEOUL; RATS AB Throughout Korea, small mammals are hosts to a number of disease-causing agents that pose a health threat to US. and Korean military forces while they conduct field-training exercises. A seasonal rodent-borne disease surveillance program was established at two firing points (FP), FP-10, and FP-60, and conducted over five years from 2001 through 2005 in response to hantavirus cases among US. soldiers. The ecology of these sites consisted primarily of tall grasses associated with semi-permanent and temporary water sources (drainage ditches and a small stream) and dry-land agriculture farming. Eight species of rodents and one species of insectivore were collected, including Apodemus agrarius, Micromys minutus, Mus musculus, Rattus norvegicus, Tscherskia triton, Microtus fortis, Myodes regulus, and Crocidura lasiura. The striped field mouse, A. agrarius, (primary reservoir for Hantaan virus, the causative agent of Korean hemorrhagic fever), was the most frequently collected, representing 90.6% of the 1,288 small mammals captured at both sites. Reported herein are the ecological parameters, seasonal population densities, and seasonal population characteristics associated with small mammals collected at two military training sites in the Republic of Korea. Journal of Vector Ecology 33 (2): 370-384. 2008. C1 [Baek, Luck-Ju; Song, Ki-Joon; Song, Fin-Won] Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea. [O'Guinn, Monica L.; Lee, John S.; Turell, Michael J.] USA, Dept Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Klein, Terry A.; Yi, Suk-Hee] 18 Med Command, Unit 15281, APO, AP 96205 USA. [Kim, Heung-Chul; Song, Fin-Won] 18 Med Command, Unit 15247, APO, AP 96205 USA. [Burkett, Douglas A.] Air Force Inst Operat Hlth, Unit 5213, Okinawa, Japan. [Schuster, Anthony] US Ctr Hlth Promot & Prevent Med S, Atlanta, GA 30330 USA. [Lee, In-Yong] Yonsei Univ, Coll Med, Dept Environm Med Biol, Seoul 120749, South Korea. [Sames, William J.] Def Logist Agcy, Ft Belvoir, VA 22060 USA. RP Song, FW (reprint author), Korea Univ, Coll Med, Dept Microbiol, 126-1,5Ka, Seoul 136705, South Korea. RI Valle, Ruben/A-7512-2013 FU US. Department of Defense Global Emerging Infections Surveillance and Response System (GEIS); Armed Forces Medical Intelligence Center, Fort Detrick FX We acknowledge the assistance of Wan-Young Kim, Edwin Huertas, and Kerry McKinley for their support in coordinating personnel for conducting rodent surveillance. We also thank the many soldiers of the Preventive Medicine Detachments, 168th Multifunctional Medical Battalion, for their support in conducting rodent surveillance throughout the five-year surveillance program. We especially thank Se-Hun Gu, So-Hee Shim, Hae-Ji Kang, and other graduate students and staff of Korea University for their support in handling and gathering of small mammal bionomics in the laboratory. We are grateful for the support and encouragement that the 18th MEDCOM commanders, Phillip Volpe and Brian Allgood (deceased), and their preventive medicine consultant Hee-Choon Lee provided throughout this study.; Research was performed in compliance with the Animal Welfare Act and other federal statues and regulations relating to animals and experiments involving animals and adhered to principles stated in the guide for the Care and Use of Laboratory Animals, National Research Council, 1996. Funding for portions of this work was provided by the US. Department of Defense Global Emerging Infections Surveillance and Response System (GEIS), Silver Spring, MD, and the Armed Forces Medical Intelligence Center, Fort Detrick, MD. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of Defense, the Department of the Army, or the U.S. Government. NR 51 TC 17 Z9 19 U1 1 U2 2 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 EI 1948-7134 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2008 VL 33 IS 2 BP 370 EP 384 PG 15 WC Entomology SC Entomology GA 395LB UT WOS:000262524500020 PM 19263858 ER PT J AU Rueda, LM Pecor, JE Lowen, RG Carder, M AF Rueda, Leopoldo M. Pecor, James E. Lowen, Robert G. Carder, Mark TI New record and updated checklists of the mosquitoes of Afghanistan and Iraq SO JOURNAL OF VECTOR ECOLOGY LA English DT Article C1 [Rueda, Leopoldo M.; Pecor, James E.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Div Entomol, Silver Spring, MD 20910 USA. [Lowen, Robert G.] USA, Ctr Hlth Promot & Prevent Med, Attn MCHB AN ES, Ft George G Meade, MD 20755 USA. [Carder, Mark] US AMEDD Ctr & Sch, Attn MCCS HPM, Acad Hlth Sci, Med Zool Branch, Ft Sam Houston, TX 78234 USA. RP Rueda, LM (reprint author), Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Div Entomol, Silver Spring, MD 20910 USA. NR 23 TC 3 Z9 3 U1 0 U2 3 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2008 VL 33 IS 2 BP 397 EP 402 PG 6 WC Entomology SC Entomology GA 395LB UT WOS:000262524500024 PM 19263862 ER PT J AU Klungthong, C Putnak, R Mammen, MP Li, T Zhang, C AF Klungthong, C. Putnak, R. Mammen, M. P. Li, T. Zhang, C. TI Molecular genotyping of dengue viruses by phylogenetic analysis of the sequences of individual genes SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Dengue viruses; Diversity; Genotyping; Individual genes ID NATURAL-POPULATIONS; CRYSTAL-STRUCTURE; TYPE-2 VIRUS; EVOLUTION; EPIDEMIOLOGY; RECOMBINATION; VENEZUELA; THAILAND AB The prevalence of four serotypes of dengue virus (DENV) has risen dramatically in recent years accompanied by an increase in viral genetic diversity. The evolution of DENV has had a major impact on their virulence for humans and on the epidemiology of dengue disease around the world. In order to perform disease surveillance and understand DENV evolution and its effects on virus transmission and disease, an efficient and accurate method for genotype identification is required. Phylogenetic analysis of viral gene sequences is the method used most commonly, with envelope (E) gene the most frequently selected target. To determine which gene might be suitable targets for genotyping DENV, phylogenetic analysis was performed on 10 individual coding genes plus the T-non-translated region (TNTR) for 56 geographically divergent DENV strains representing all identified genotypes. These were reflected in eleven maximum likelihood phylogenetic trees. Based on the bootstrap values (over 90%) supporting the major nodes, the best target genes were identified for each serotype: for DENV-1, the sequences of all coding genes except non-structural gene 4A (NS4A), for DENV-2, PrM/M, E, NS1, NS3, NS4A and NS5, for DENV-3, all coding genes and the TNTR, and for DENV-4, C, PrM/M, E, NS1, NS2A, NS2B, NS4A and NS5. Published by Elsevier B.V. C1 [Putnak, R.; Li, T.; Zhang, C.] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Klungthong, C.; Mammen, M. P.; Zhang, C.] USA, Med Component Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand. RP Zhang, C (reprint author), Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. EM chunlin.zhang@amedd.army.mil FU Military Infectious Disease Research Program (MIDRP); United States Army Medical Research and Materiel Command, Fort Detrick FX This work was funded by the Military Infectious Disease Research Program (MIDRP) and the United States Army Medical Research and Materiel Command, Fort Detrick, MD. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the official views of the United States Army or the Department of Defense. NR 32 TC 27 Z9 28 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD DEC PY 2008 VL 154 IS 1-2 BP 175 EP 181 DI 10.1016/j.jviromet.2008.07.021 PG 7 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 385UJ UT WOS:000261838800025 PM 18778736 ER PT J AU Redden, ES Elliott, LR Pettitt, RA Carstens, CB AF Redden, Elizabeth S. Elliott, Linda R. Pettitt, Rodger A. Carstens, Christian B. TI A tactile option to reduce robot controller size SO JOURNAL ON MULTIMODAL USER INTERFACES LA English DT Article DE Robot control; Mobile computing; Haptic; design; Human-computer interface; Tactile display; Split screen displays AB In response to operational requirements for smaller robotic controller devices for use by dismounted US Army soldiers, three types of robot controller navigation map display configurations were evaluated for effects on beyond line-of-sight robotic navigation tasks. We predicted better performance with the larger split screen display that presents both a map display and a camera-based driving display on a 6.5 inch screen. Two smaller alternatives were also evaluated. One alternative was a 3.5 inch display that allowed the operator to toggle back and forth between the driving display and the map display. The third option added a torso-mounted tactile display to the toggle-based display in order to provide direction information simultaneously with the camera display and thus reduce the need to toggle as frequently to the map display. Each display option was evaluated based on objective performance data, expert-based observations, and scaled subjective soldier questionnaire items. Findings indicated that operators' navigation performance with the multimodal 3.5 inch toggle display was as effective as their performance with a 6.5 inch split screen display. Operator performance was significantly lower with the 3.5 inch toggle display that did not have the tactile display. C1 [Redden, Elizabeth S.; Elliott, Linda R.; Pettitt, Rodger A.; Carstens, Christian B.] USA, Res Lab, USAIC Human Res & Engn Field Element, Ft Benning, GA USA. RP Elliott, LR (reprint author), USA, Res Lab, USAIC Human Res & Engn Field Element, Bldg 4,Rm 59, Ft Benning, GA USA. EM Linda.r.elliott@us.army.mil NR 29 TC 1 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1783-7677 J9 J MULTIMODAL USER IN JI J. Multimodal User Interfaces PD DEC PY 2008 VL 2 IS 3-4 BP 205 EP 216 DI 10.1007/s12193-009-0019-3 PG 12 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Computer Science GA V26HO UT WOS:000208536900006 ER PT J AU Hannah, ST Avolio, BJ Luthans, F Harms, PD AF Hannah, Sean T. Avolio, Bruce J. Luthans, Fred Harms, P. D. TI Leadership efficacy: Review and future directions SO LEADERSHIP QUARTERLY LA English DT Review DE Leader efficacy; Agency; Collective efficacy; Means efficacy; Leadership ID SOCIAL-COGNITIVE THEORY; POSITIVE ORGANIZATIONAL-BEHAVIOR; COMPLEX DECISION-MAKING; PERCEIVED SELF-EFFICACY; TRANSFORMATIONAL LEADERSHIP; COLLECTIVE-EFFICACY; GOAL ORIENTATION; CHARISMATIC LEADERSHIP; PERFORMANCE FEEDBACK; PERSONALITY-TRAITS AB The concept of leader efficacy has received relatively little attention in the leadership literature. This is somewhat surprising given that effective leadership requires high levels of agency (i.e., deliberately or intentionally exerting positive influence) and confidence. This review uses existing theory and research on leader efficacy as a point of departure for proposing an expanded and multi-level framework for understanding the domain of leadership efficacy that includes leader, follower, and collective efficacies. The primary goals are to provide a conceptual framework to stimulate future theory and research on building efficacious leadership and to understand how such leadership develops and has implications for effective performance. Published by Elsevier Inc. C1 [Hannah, Sean T.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Avolio, Bruce J.] Univ Washington, Foster Business Sch, Dept Management & Org, Seattle, WA 98195 USA. [Luthans, Fred; Harms, P. D.] Univ Nebraska, Coll Business Adm, Dept Management, Lincoln, NE 68588 USA. RP Hannah, ST (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. EM Sean.hannah@usma.edu NR 220 TC 67 Z9 68 U1 6 U2 94 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 EI 1873-3409 J9 LEADERSHIP QUART JI Leadersh. Q. PD DEC PY 2008 VL 19 IS 6 BP 669 EP 692 DI 10.1016/j.leaqua.2008.09.007 PG 24 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 379AJ UT WOS:000261366300004 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI My Private War: Liberated Body, Captive Mind; A World War II POW's Journey SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD DEC PY 2008 VL 133 IS 20 BP 135 EP 136 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 382KJ UT WOS:000261604400200 ER PT J AU Stephenson, LD Kumar, A AF Stephenson, L. D. Kumar, Ashok TI CASE HISTORY Advanced Coatings for Water Treatment Plant Components SO MATERIALS PERFORMANCE LA English DT Article AB Components of water treatment plants (WTPs) are susceptible to corrosion from constant immersion in water A case history of corrosion and proximity to chlorine. problems and their treatment at an Army WTP is presented Solutions included using high micro-silica restoration mortar and advanced coal tar epoxy coatings. C1 [Stephenson, L. D.; Kumar, Ashok] USA, Erdc, CERL, Champaign, IL 61826 USA. RP Stephenson, LD (reprint author), USA, Erdc, CERL, POB 9005, Champaign, IL 61826 USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD DEC PY 2008 VL 47 IS 12 BP 40 EP 45 PG 6 WC Materials Science, Characterization & Testing SC Materials Science GA 381NT UT WOS:000261543900009 ER PT J AU Vecherin, SN Ostashev, VE Wilson, DK Ziemann, A AF Vecherin, Sergey N. Ostashev, Vladimir E. Wilson, D. Keith Ziemann, A. TI Time-dependent stochastic inversion in acoustic tomography of the atmosphere with reciprocal sound transmission SO MEASUREMENT SCIENCE AND TECHNOLOGY LA English DT Article DE travel-time tomography; inverse problems; acoustic imaging; remote sensing; tomography of the atmosphere; stochastic inversion ID KALMAN FILTER; VECTOR-FIELDS; SURFACE-LAYER; RECONSTRUCTION; TEMPERATURE; RESTORATION; TURBULENCE; FLOW AB Time-dependent stochastic inversion (TDSI) was recently developed for acoustic travel-time tomography of the atmosphere. This type of tomography allows reconstruction of temperature and wind-velocity fields given the location of sound sources and receivers and the travel times between all source-receiver pairs. The quality of reconstruction provided by TDSI depends on the geometry of the transducer array. However, TDSI has not been studied for the geometry with reciprocal sound transmission. This paper is focused on three aspects of TDSI. First, the use of TDSI in reciprocal sound transmission arrays is studied in numerical and physical experiments. Second, efficiency of time-dependent and ordinary stochastic inversion ( SI) algorithms is studied in numerical experiments. Third, a new model of noise in the input data for TDSI is developed that accounts for systematic errors in transducer positions. It is shown that (i) a separation of the travel times into temperature and wind-velocity components in tomography with reciprocal transmission does not improve the reconstruction, (ii) TDSI yields a better reconstruction than SI and (iii) the developed model of noise yields an accurate reconstruction of turbulent fields and estimation of errors in the reconstruction. C1 [Vecherin, Sergey N.; Ostashev, Vladimir E.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. [Vecherin, Sergey N.] USA, Signature Phys Branch, Erdc, CRREL, Hanover, NH 03755 USA. [Ostashev, Vladimir E.] NOAA, Earth Syst Res Lab, Boulder, CO 80305 USA. [Ziemann, A.] Univ Leipzig, Inst Meteorol, D-04103 Leipzig, Germany. RP Vecherin, SN (reprint author), USA, Signature Phys Branch, Erdc, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM Sergey.N.Vecherin@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 39 TC 4 Z9 4 U1 1 U2 3 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-0233 EI 1361-6501 J9 MEAS SCI TECHNOL JI Meas. Sci. Technol. PD DEC PY 2008 VL 19 IS 12 AR 125501 DI 10.1088/0957-0233/19/12/125501 PG 12 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 370JR UT WOS:000260759000015 ER PT J AU Desyatova, AS Zhigalov, MV Krys'ko, VA Saltykova, OA AF Desyatova, A. S. Zhigalov, M. V. Krys'ko, V. A. Saltykova, O. A. TI Dissipative dynamics of geometrically nonlinear Bernoulli-Euler beams SO MECHANICS OF SOLIDS LA English DT Article ID COMPLEX PARAMETRIC VIBRATIONS; PLATES; BIFURCATIONS AB We consider nonlinear dissipative vibrations of the Bernoulli-Euler beam. We find that, under the action of a transverse alternating load, the vibrations may become chaotic. We study a scenario in which harmonic vibrations become chaotic, namely, the Feigenbaum scenario, and find the Feigenbaumconstant. In the present paper, we paymuch attention to the reliability of the results obtained. To this end, we use two methods, the finite difference O(h (2)) method and the finite element method in the Bubnov-Galerkin form, and verify the convergence of these methods. C1 [Desyatova, A. S.] USA, Washington, DC 20310 USA. [Zhigalov, M. V.; Krys'ko, V. A.; Saltykova, O. A.] Saratov State Tech Univ, Saratov 410054, Russia. RP Desyatova, AS (reprint author), USA, Washington, DC 20310 USA. EM desyatova@mail.ru; ZhigalovM@yandex.ru; tak@san.ru; olga_a_saltykova@mail.ru OI Krysko, V.A./0000-0002-4914-764X FU Russian Foundation for Basic Research [06-08-01357a] FX The research was supported by the Russian Foundation for Basic Research, grant no. 06-08-01357a. NR 15 TC 1 Z9 1 U1 1 U2 7 PU ALLERTON PRESS INC PI NEW YORK PA 18 WEST 27TH ST, NEW YORK, NY 10001 USA SN 0025-6544 J9 MECH SOLIDS+ JI Mech. Sol. PD DEC PY 2008 VL 43 IS 6 BP 948 EP 956 DI 10.3103/S0025654408060125 PG 9 WC Mechanics SC Mechanics GA 397QB UT WOS:000262676100012 ER PT J AU Nelson, MWJ AF Nelson, Major William J. TI A RIGHT WAY AND A WRONG WAY: REMEDYING EXCESSIVE POST-TRIAL DELAY IN LIGHT OF TARDIF, MORENO, AND TOOHEY SO MILITARY LAW REVIEW LA English DT Article C1 USA, Washington, DC 20310 USA. RP Nelson, MWJ (reprint author), USA, Washington, DC 20310 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2008 VL 198 BP 1 EP 66 PG 66 WC Law SC Government & Law GA 405DD UT WOS:000263201900001 ER PT J AU Kiel, JL AF Kiel, John Lopan, Jr. TI CROSSING THE LINE: RECONCILING THE RIGHT TO PICKET MILITARY FUNERALS WITH THE FIRST AMENDMENT SO MILITARY LAW REVIEW LA English DT Article C1 USA, Washington, DC 20310 USA. RP Kiel, JL (reprint author), USA, Washington, DC 20310 USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2008 VL 198 BP 67 EP 115 PG 49 WC Law SC Government & Law GA 405DD UT WOS:000263201900002 ER PT J AU Marsh, JJ AF Marsh, J. Jeremy TI LEX LATA OR LEX FERENDA? RULE 45 OF THE ICRC STUDY ON CUSTOMARY INTERNATIONAL HUMANITARIAN LAW SO MILITARY LAW REVIEW LA English DT Article RP Marsh, JJ (reprint author), USA, TJAGLCS, Int & Operat Law Dept, Charlottesville, VA USA. NR 11 TC 2 Z9 2 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2008 VL 198 BP 116 EP 164 PG 49 WC Law SC Government & Law GA 405DD UT WOS:000263201900003 ER PT J AU Lowery, TE AF Lowery, Tyesha E. TI ONE "GET OUT OF JAIL FREE" CARD: SHOULD PROBATION BE AN AUTHORIZED COURTS-MARTIAL PUNISHMENT? SO MILITARY LAW REVIEW LA English DT Article C1 USA, TJAGLCS, Washington, DC 20310 USA. RP Lowery, TE (reprint author), USA, TJAGLCS, Washington, DC 20310 USA. NR 15 TC 3 Z9 3 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2008 VL 198 BP 165 EP 209 PG 45 WC Law SC Government & Law GA 405DD UT WOS:000263201900004 ER PT J AU Gavula, BP AF Gavula, Brian P. TI THE TERROR PRESIDENCY: LAW AND JUDGMENT INSIDE THE BUSH ADMINISTRATION SO MILITARY LAW REVIEW LA English DT Article C1 USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 57, Charlottesville, VA USA. RP Gavula, BP (reprint author), USA, Judge Advocate Gen Legal Ctr & Sch, Judge Advocate Officer Grad Course 57, Charlottesville, VA USA. NR 8 TC 0 Z9 0 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2008 VL 198 BP 210 EP 218 PG 9 WC Law SC Government & Law GA 405DD UT WOS:000263201900005 ER PT J AU Kwon, WH AF Kwon, Walter H. TI THE POST-AMERICAN WORLD SO MILITARY LAW REVIEW LA English DT Article C1 USA, Judge Advocate Officer Grad Course 57, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. RP Kwon, WH (reprint author), USA, Judge Advocate Officer Grad Course 57, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2008 VL 198 BP 219 EP 226 PG 8 WC Law SC Government & Law GA 405DD UT WOS:000263201900006 ER PT J AU Hutchinson, JW Greene, JP Hansen, SL AF Hutchinson, Jeffrey W. Greene, Jeffery P. Hansen, Shana L. TI Evaluating Active Duty Risk-Taking: Military Home, Education, Activity, Drugs, Sex, Suicide, and Safety Method SO MILITARY MEDICINE LA English DT Article AB Psychosocial screening tools are routinely used by adolescent medicine providers to evaluate risk-taking behaviors and resiliency. A large number of U.S. military service members are adolescents, and many engage in behaviors that cause morbidity and death, such as tobacco use and binge drinking. Health care providers should consider the regular use of a psychosocial screening method to evaluate risk-taking behavior. The Home, Education, Activity, Drugs, Sex, Suicide, and Safety method is used to evaluate the home environment, educational and employment situations, activities, drug use, sexual activity, suicide, and safety during health care visits. This technique, originally created for a civilian adolescent population, can be used with minimal adjustments to evaluate behaviors of military service members. C1 [Hutchinson, Jeffrey W.] Walter Reed Army Med Ctr, Adolescent Med Dept, Washington, DC 20307 USA. [Greene, Jeffery P.] Tripler Army Med Ctr, Adolescent Med Dept, Honolulu, HI 96859 USA. [Hansen, Shana L.] Brooke Army Med Ctr, Adolescent Med Dept, Ft Sam Houston, TX 78234 USA. RP Hutchinson, JW (reprint author), Walter Reed Army Med Ctr, Adolescent Med Dept, Washington, DC 20307 USA. NR 39 TC 7 Z9 7 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2008 VL 173 IS 12 BP 1164 EP 1167 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA V11ZO UT WOS:000207569700006 PM 19149332 ER PT J AU Ivins, BJ Crowley, JS Johnson, J Warden, DL Schwab, KA AF Ivins, Brian J. Crowley, John S. Johnson, Jeffrey Warden, Deborah L. Schwab, Karen A. TI Traumatic Brain Injury Risk While Parachuting: Comparison of the Personnel Armor System for Ground Troops Helmet and the Advanced Combat Helmet SO MILITARY MEDICINE LA English DT Article AB Military paratroopers are inherently at risk for a variety of injuries when they jump, including traumatic brain injuries (TBIs). U.S. Army paratroopers rely on their ballistic helmets for protection against TBIs when jumping. Currently, two different helmets are available to Army paratroopers, that is, the personnel armor system for ground troops helmet and the advanced combat helmet. This study compared the incidence of self-reported, jump-related TBIs in a small sample of paratroopers (N = 585) using each type of helmet. Data were obtained from surveys of soldiers at Fort Bragg, North Carolina. The overall relative risk of sustaining a TBI while jumping was 2.3 times (95% confidence interval, 1.3-4.3) higher for personnel armor system for ground troops helmet users. Most of the increase in risk was accounted for by the most-minor TBIs (American Academy of Neurology grade I or 2 concussion). C1 [Ivins, Brian J.; Warden, Deborah L.; Schwab, Karen A.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. [Crowley, John S.] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. [Johnson, Jeffrey] Irwin Army Community Hosp, Ft Riley, KS 66442 USA. RP Ivins, BJ (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. NR 19 TC 3 Z9 3 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2008 VL 173 IS 12 BP 1168 EP 1172 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V11ZO UT WOS:000207569700007 PM 19149333 ER PT J AU Bir, C Barbir, A Dosquett, F Wilhelm, M van der Horst, M Wolfe, G AF Bir, Cynthia Barbir, Ana Dosquett, Frank Wilhelm, Marianne van der Horst, Marike Wolfe, Greg TI Validation of Lower Limb Surrogates as Injury Assessment Tools in Floor Impacts due to Anti-Vehicular Land Mines SO MILITARY MEDICINE LA English DT Article AB The aim of this study was to assess the ability of lower limb surrogates to predict injury due to floor/foot plate impact in military vehicles during anti-vehicular land mine explosions. Testing was conducted using two loading conditions simulated to represent those conditions created in the field. The lower condition was represented by a 24-kg mass impactor with a velocity of 4.7 m/s. The higher loading condition was represented by a 37-kg mass impactor with a velocity of 8.3 m/s. Two biomechanical surrogates were evaluated using the loading conditions: 50th percentile Hybrid III foot/ankle and Test Device for Human Occupant Restraint THOR-Lx. Comparisons of the force-time response were made to established corridors. Results show a better correlation to the corridors with the THOR-Lx; however, future improvements to the THOR-Lx are recommended. C1 [Bir, Cynthia; Barbir, Ana; Wilhelm, Marianne] Wayne State Univ, Detroit, MI 48201 USA. [Dosquett, Frank] Tech Ctr Weap & Ammunit, WTD 91, D-49716 Meppen, Germany. [van der Horst, Marike] TNO Def Secur & Safety, NL-2280 AA Rijswijk, Netherlands. [Wolfe, Greg] USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Bir, C (reprint author), Wayne State Univ, 818 W Hancock, Detroit, MI 48201 USA. FU U.S. Army TACOM [W56HZV-05-P-L511] FX Funding for this study was in part from U.S. Army TACOM Contract W56HZV-05-P-L511. NR 15 TC 9 Z9 10 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2008 VL 173 IS 12 BP 1180 EP 1184 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA V11ZO UT WOS:000207569700009 PM 19149335 ER PT J AU Fulton, L Starnes, W Caouette, M Whittaker, D Ivanitskaya, L AF Fulton, Larty Starnes, William Caouette, Marc Whittaker, Donna Ivanitskaya, Lana TI Explaining and Forecasting Attrition in the Army Pharmacy Technician Course SO MILITARY MEDICINE LA English DT Article AB The Army pharmacy technician (68Q) course trains similar to 260 students per year, with a mean graduation rate of 71.3%. In support of this course, a research team conducted a study using multiple analytical methods to evaluate, to explain, and potentially to forecast failures, because the 28.7% of students who do not graduate are associated with both opportunity and real costs. Results of this study indicated that largely uncontrollable population demographic characteristics, such as rank and enrollment status, along with controllable Armed Services Vocational Aptitude Battery skilled technical test scores, were related to graduation rates. The results of this study may be used to assist individuals at risk of failure or to establish additional admission criteria to increase the likelihood of success. C1 [Fulton, Larty; Starnes, William; Caouette, Marc; Whittaker, Donna] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Ivanitskaya, Lana] Cent Michigan Univ, Mt Pleasant, MI 48859 USA. RP Fulton, L (reprint author), USA, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RI Ivanitskaya, Lana/G-5385-2011 NR 5 TC 1 Z9 1 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2008 VL 173 IS 12 BP 1219 EP 1224 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA V11ZO UT WOS:000207569700017 PM 19149343 ER PT J AU Query, P AF Query, Patrick TI Crooked Europe: The Verse Drama of W.H. Auden (and Company) SO MODERN DRAMA LA English DT Article DE W.H. Auden; verse drama; ritual; Europe; collaboration AB In this essay I argue that the trajectory of W.H. Auden's short career in verse drama describes the impossibility of its own objective: the use of ritual to represent a coherent idea of Europe without invoking an objective historical or spiritual tradition. His verse plays, born out of a commitment to drama's ritual origins and potential, offer a useful measure of the difficulty of imagining European cultural cohesion in the interwar period. Auden's plays employ a host of formal strategies to recreate the conditions of ritual, with some success. Moreover, Auden's plays, especially those written in collaboration with Christopher Isherwood, also wrestle with the problem of European political and cultural atomization. The solutions the plays offer, while often dramatically compelling, ultimately do not move beyond the political limitations and cultural disorders they describe, a shortcoming Auden later came to see in terms of the absence of tradition. C1 US Mil Acad, West Point, NY 10996 USA. RP Query, P (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 33 TC 1 Z9 1 U1 0 U2 0 PU UNIV TORONTO PRESS INC PI TORONTO PA JOURNALS DIVISION, 5201 DUFFERIN ST, DOWNSVIEW, TORONTO, ON M3H 5T8, CANADA SN 0026-7694 J9 MOD DRAMA JI Mod. Drama PD WIN PY 2008 VL 51 IS 4 BP 579 EP 604 DI 10.3138/md.51.4.579 PG 26 WC Theater SC Theater GA 415ND UT WOS:000263939700007 ER PT J AU Evans, AF Wertheimer, RH Keefer, ML Boggs, CT Peery, CA Collis, K AF Evans, Allen F. Wertheimer, Robert H. Keefer, Matthew L. Boggs, Charles T. Peery, Christopher A. Collis, Ken TI Transportation of Steelhead Kelts to Increase Iteroparity in the Columbia and Snake Rivers SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Article ID LIFE-HISTORY CHARACTERISTICS; TROUT SALMO-GAIRDNERI; ATLANTIC SALMON; ONCORHYNCHUS-MYKISS; HATCHERY; SALAR; FISH; WILD; VARIABILITY; WASHINGTON AB We tested the feasibility of transporting steelhead Oncorhynchus mykiss kelts (postspawned adults) around hydroelectric dams on the Snake and Columbia rivers to increase the returns of repeat spawners. Altogether, 5,878 kelts were collected, tagged with passive integrated transponder tags, and assigned to transported or in-river treatment groups at Lower Granite Dam (n = 5,320 [2002-2004]) on the Snake River and John Day Dam (n = 558 [2002]) on the Columbia River. Returns of repeat spawners differed by site and year: 11.1% (62/558) for the John Day Dam sample and 1.4% (27/1,959), 0.5% (6/1,24 1), and 0.8% (17/2,120) for the Lower Granite Darn samples in 2002, 2003, and 2004. respectively. Transportation tests indicated that kelts transported from the Snake River were approximately 2.3 times more likely to return than fish allowed to migrate in-river. Transport benefits were greatest for wild-origin female kelts, a demographic with high conservation value. There was no significant benefit for kelts transported from John Day Dam, although transported fish returned at a slighter higher rate (1.1 times). Comparisons between treatment groups (in-river versus transport) and locations (Snake River versus Columbia River) indicated that the greatest potential transport benefit may be for Snake River kelts owing to the population's low overall iteroparity rate and numerous potential kelt collection sites. The small sample sizes of returning fish limited our ability to examine more complex trends and environmental effects on return rates. Additional research is needed to fully evaluate the efficacy of kelt transportation in the context of regional steelhead recovery efforts. C1 [Evans, Allen F.; Collis, Ken] Real Time Res Inc, Bend, OR 97702 USA. [Wertheimer, Robert H.] USA, Corps Engineers, Portland, OR 97208 USA. [Keefer, Matthew L.; Boggs, Charles T.; Peery, Christopher A.] Univ Idaho, Dept Fish & Wildlife Resources, Idaho Cooperat Fish & Wildlife Res Unit, Moscow, ID 83844 USA. RP Evans, AF (reprint author), Real Time Res Inc, 52 SW Roosevelt Ave, Bend, OR 97702 USA. EM aevans@realtimeresearch.org FU U.S. Army Corps of' Engineers, Walla Walla District FX This project was funded by the U.S. Army Corps of' Engineers, Walla Walla District. We thank T. Wik and M. Shutters for their assistance, as well as M. Halter, J. Harmon, and the staff at Lower Granite Dam, and R. Cordie, M. Zyndol and the staff at John Day Darn. We are grateful to J. Dalen, P. Madson, M. Jonas, B. Winans, E. O'Brien, C. Naumann, and J. Sandquist for their fieldwork, G. Nardacci (Norniandeau Associates) for project oversight, and R. Beaty (Bonneville Power Administration) for his innovative ideas regarding this research. Finally, we thank the staff of the Columbia River Inter-Tribal Fish Commission for their involvement in this work. NR 36 TC 9 Z9 9 U1 2 U2 8 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD DEC PY 2008 VL 28 IS 6 BP 1818 EP 1827 DI 10.1577/M08-043.1 PG 10 WC Fisheries SC Fisheries GA 477FS UT WOS:000268504700017 ER PT J AU Weichel, ED Colyer, MH Ludlow, SE Bower, KS Eiseman, AS AF Weichel, Eric D. Colyer, Marcus H. Ludlow, Spencer E. Bower, Kraig S. Eiseman, Andrew S. TI Combat Ocular Trauma Visual Outcomes during Operations Iraqi and Enduring Freedom SO OPHTHALMOLOGY LA English DT Article ID OPEN-GLOBE INJURIES; CLASSIFYING MECHANICAL INJURIES; UNITED-STATES; EYE INJURIES; PROGNOSTIC FACTORS; DESERT-SHIELD; BRAIN-INJURY; WAR; SURVIVAL; EPIDEMIOLOGY AB Objective: To report the visual and anatomic outcomes as well as to predict the visual prognosis of combat ocular trauma (COT) during Operations Iraqi and Enduring Freedom. Design: Retrospective, noncomparative, interventional, consecutive case series. Participants: Five hundred twenty-three consecutive globe or adnexal combat injuries, or both, sustained by 387 United States soldiers treated at Walter Reed Army Medical Center between March 2003 and October 2006. Methods: Two hundred one ocular trauma variables were collected on each injured soldier. Best-corrected visual acuity (BCVA) was categorized using the ocular trauma score (OTS) grading system and was analyzed by comparing initial and 6-month postinjury BCVA. Main Outcome Measures: Best-corrected visual acuity, OTS, and globe, oculoplastic, neuro-ophthalmic, and associated nonocular injuries. Results: The median age was 25 7 years (range, 18-57 years), with the median baseline OTS of 70 25 (range, 12-100). The types of COT included closed-globe (n = 234; zone 1+2, n = 103; zone 3, n = 131), open-globe (n = 198; intraocular foreign body, n = 86; perforating, n = 61; penetrating, n = 32; and rupture, n = 19), oculoplastic (n = 324), and neuro-ophthalmic (n = 135) injuries. Globe trauma was present in 432 eyes, with 253 eyes used for visual acuity analysis. Comparing initial versus 6-month BCVA, 42% of eyes achieved a BCVA of 20/40 or better, whereas 32% of eyes had a BCVA of no light perception. Closed-globe injuries accounted for 65% of BCVA of 20/40 or better, whereas 75% of open-globe injuries had a BCVA of 20/200 or worse. The ocular injuries with the worst visual outcomes included choroidal hemorrhage, globe perforation or rupture, retinal detachment, submacular hemorrhage, and traumatic optic neuropathy. Additionally, COT that combined globe injury with oculoplastic or neuro-ophthalmologic injury resulted in the highest risk of final BCVA worse than 20/200 (odds ratio, 11.8; 95% confidence interval, 4.0-34.7; P<0.0005). Nonocular injuries occurred in 85% of cases and included traumatic brain injury (66%) and facial injury (58%). Extremity injuries were 44% (170 of 387 soldiers). Amputation is a subset of extremity injury with 12% (46 of 387) having sustained a severe extremity injury causing amputation. Conclusions: Combat ocular trauma has high rates of nonocular injuries with better visual outcomes in closed-globe compared with open-globe trauma. The OTS is a valid classification scheme for COT and correlates the severity of injury with the final visual acuity and prognosis. Globe combined with oculoplastic or neuro-ophthalmologic injuries have the worst visual prognosis. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2008;115:2235-2245 (C) 2008 by the American Academy of Ophthalmology. C1 [Weichel, Eric D.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. RP Weichel, ED (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM eweichel@hotmail.com NR 68 TC 68 Z9 74 U1 2 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD DEC PY 2008 VL 115 IS 12 BP 2235 EP 2245 DI 10.1016/j.ophtha.2009.08.033 PG 11 WC Ophthalmology SC Ophthalmology GA 381PK UT WOS:000261548200017 PM 19041478 ER PT J AU Merkle, LD Newburgh, GA Ter-Gabrielyan, N Michael, A Dubinskii, M AF Merkle, Larry D. Newburgh, G. Alex Ter-Gabrielyan, Nikolay Michael, Arockiasamy Dubinskii, Mark TI Temperature-dependent lasing and spectroscopy of Yb:Y(2)O(3) and Yb:Sc(2)O(3) SO OPTICS COMMUNICATIONS LA English DT Article DE Laser materials; Condensed matter spectroscopy ID YB-Y2O3 CERAMIC LASER; ND-YAG; YB-YAG; SESQUIOXIDES; YB3+-SC2O3; OPERATION; EMISSION; CRYSTALS AB Spectroscopic and laser properties of Yb(3+) in ceramic Y(2)O(3) have been studied at room and cryogenic temperatures. Laser performance is very substantially improved by cooling to liquid nitrogen temperature, primarily due to the great reduction in ground state absorption that permits laser operation on the much stronger 1030-nm emission line rather than the 1077-nm line. The 976-nm "zero line" is observed to become much weaker as the temperature is reduced. Several models for this behavior are considered, but none adequately explains this surprising result. Spectroscopy of Yb:Sc(2)O(3) indicates that it is likely to be an even better cryogenic gain material, given samples of comparable optical quality. (C) 2008 Elsevier B.V. All rights reserved. C1 [Merkle, Larry D.; Newburgh, G. Alex; Ter-Gabrielyan, Nikolay; Michael, Arockiasamy; Dubinskii, Mark] Attn AMSRD ARL SE EO, Army Res Lab, Adelphi, MD 20783 USA. RP Merkle, LD (reprint author), Attn AMSRD ARL SE EO, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM larry.d.merkle@us.army.mil FU High Energy Lasers Joint Technology Office FX The authors wish to thank Thomas Backes for his careful contributions to the early spectroscopic phases of this study, and to gratefully acknowledge financial support from the High Energy Lasers Joint Technology Office. NR 20 TC 17 Z9 17 U1 4 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD DEC 1 PY 2008 VL 281 IS 23 BP 5855 EP 5861 DI 10.1016/j.optcom.2008.08.043 PG 7 WC Optics SC Optics GA 378AS UT WOS:000261294100039 ER PT J AU Gentlesk, PJ Sauer, WH Peele, ME Eckart, RE AF Gentlesk, Philip J. Sauer, William H. Peele, Mark E. Eckart, Robert E. TI Spontaneous Premature Atrial Depolarization Proving the Mechanism of a Wide Complex Tachycardia SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY LA English DT Article DE catheter ablation; WPW; AVRT; cardiac mapping; electrogram analysis ID MAHAIM FIBER C1 [Gentlesk, Philip J.] Brooke Army Med Ctr, Div Cardiol MCHE MDC, Ft Sam Houston, TX 78234 USA. [Sauer, William H.] Univ Colorado Hosp, Denver, CO USA. RP Gentlesk, PJ (reprint author), Brooke Army Med Ctr, Div Cardiol MCHE MDC, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Philip.Gentlesk@amedd.army.mil NR 4 TC 2 Z9 2 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0147-8389 J9 PACE JI PACE-Pacing Clin. Electrophysiol. PD DEC PY 2008 VL 31 IS 12 BP 1625 EP 1627 DI 10.1111/j.1540-8159.2008.01236.x PG 3 WC Cardiac & Cardiovascular Systems; Engineering, Biomedical SC Cardiovascular System & Cardiology; Engineering GA 374YJ UT WOS:000261079300016 PM 19067817 ER PT J AU McAdams, RM Ellis, MW Trevino, S Rajnik, M AF McAdams, Ryan M. Ellis, Michael W. Trevino, Sherry Rajnik, Michael TI Spread of methicillin-resistant Staphylococcus aureus USA300 in a neonatal intensive care unit SO PEDIATRICS INTERNATIONAL LA English DT Article DE infant; infection control; methicillin-resistant Staphylococcus aureus; USA300 ID FIELD GEL-ELECTROPHORESIS; PANTON-VALENTINE LEUKOCIDIN; NOSOCOMIAL TRANSMISSION; INFECTION; CHILDREN; EMERGENCE; STRAINS; COLONIZATION; SURVEILLANCE; HOUSEHOLDS AB Reports of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in neonatal intensive care units (NICU) and in otherwise healthy patients without obvious risk factors have been increasing in frequency. Described herein is a cluster of cases of CA-MRSA USA300 strains in an NICU affecting infants, health-care workers and the health-care workers' families. Infants and health-care workers with infection and colonization due to MRSA between 1 January 2004 and 30 June 2005 in a tertiary care center NICU in San Antonio, TX were studied. Antimicrobial susceptibility testing and polymerase chain reaction detection of the mecA gene characterized the MRSA isolates. All MRSA cases were reviewed for clinical severity of infection and outcome. During the 18 months studied, a total of four (0.6%) of 676 infants had CA-MRSA bacteremia or colonization. One infant with necrotizing pneumonia died and three health-care workers who directly cared for the infected infants developed soft-tissue infections caused by CA-MRSA. Four family members of two health-care workers subsequently developed soft-tissue infections. All of the analyzed isolates (eight of nine) belonged to pulsed-field type USA300 and possessed Panton-Valentine leukocidin genes, which have been associated with severe skin and soft-tissue infections, and necrotizing pneumonia. It is likely that the CA-MRSA USA300 strain can be transmitted between NICU patients to health-care workers and their family members. The CA-MRSA cases reported here reinforce the virulence of CA-MRSA USA300 strains and emphasize the need to embrace infection control practices designed to protect hospitalized patients, health-care workers and their family members. C1 [McAdams, Ryan M.] US Naval Hosp Okinawa, Dept Neonatol, Fpo, AP 963621600, Japan. [McAdams, Ryan M.] 18th Med Grp, Kadena Air Base, Japan. [McAdams, Ryan M.; Rajnik, Michael] Wilford Hall USAF Med Ctr, Dept Pediat, San Antonio, TX 78236 USA. [Trevino, Sherry] Wilford Hall USAF Med Ctr, Dept Pathol, San Antonio, TX 78236 USA. [Ellis, Michael W.] Brooke Army Med Ctr, Dept Infect Dis, San Antonio, TX USA. [Rajnik, Michael] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP McAdams, RM (reprint author), US Naval Hosp Okinawa, Dept Neonatol, PSC 482, Fpo, AP 963621600, Japan. EM ryan.mcadams@.med.navy.mil NR 48 TC 22 Z9 24 U1 1 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1328-8067 J9 PEDIATR INT JI Pediatr. Int. PD DEC PY 2008 VL 50 IS 6 BP 810 EP 815 DI 10.1111/j.1442-200X.2008.02646.x PG 6 WC Pediatrics SC Pediatrics GA 374YU UT WOS:000261080400004 PM 19067897 ER PT J AU Schnall, BL Baum, BS Andrews, AM AF Schnall, Barri L. Baum, Brian S. Andrews, Anne M. TI Gait Characteristics of a Soldier With a Traumatic Hip Disarticulation SO PHYSICAL THERAPY LA English DT Article ID ENERGY-EXPENDITURE; KNEE STABILITY; AMPUTEES; AMPUTATION; WALKING; SPEED AB Background and Purpose. No reports have analyzed the temporal-spatial, kinematic, or kinetic components of gait coupled with a metabolic analysis of patients with hip disarticulations. Most of the research on this population is based on older adults. As a result, guidelines for reasonable functional outcomes for patients with hip disarticulations who are Young, premorbidly fit, and goal oriented are lacking. This report describes quantitative measures of energy cost and gait characteristics of a young soldier with a unilateral traumatic hip disarticulation. Case Description. One patient, a soldier with a unilateral hip disarticulation, was evaluated in the Gait and Motion Analysis Laboratory at 3 months and 38 months postinjury. Outcomes. The patient progressed from use of crutches at 3 months postinjury to independent ambulation at the follow-up visit at 38 months postinjury. At 38 months postinjury, lie wore his prosthesis 12 hours per day and achieved step-length symmetry, and his oxygen consumption was 14.49 mL/kg/min at self-selected walking speed. Self-selected walking speed increased from 0.57 m/s at 3 months to 0.86 m/s at 38 months postinjury. During both visits, support time remained greater on the intact limb (72%) than the involved limb (57%), compensator), trunk and pelvic motions were used to advance the prosthetic limb, and the vertical ground reaction force profile was within 2 standard deviations of the data for an uninjured comparison group on the prosthetic side and plateaued on the sound limb. Discussion. Young individuals with traumatic hip disarticulations can achieve and maintain functional independent ambulation with gait deviations. However, metabolic demands may not be as great as previously expected. C1 [Schnall, Barri L.; Baum, Brian S.] Walter Reed Army Med Ctr, Mil Adv Training Ctr, Ctr Performance & Clin Res, Washington, DC 20307 USA. [Andrews, Anne M.] Walter Reed Army Med Ctr, Nutr Care Directorate, Div Res & Educ, Washington, DC USA. RP Schnall, BL (reprint author), Walter Reed Army Med Ctr, Mil Adv Training Ctr, Ctr Performance & Clin Res, Bldg 2A,Room 146,6900 Georgia Ave NW, Washington, DC 20307 USA. EM barri.schnall@na.amedd.army.mil RI Baum, Brian/K-2737-2012 OI Baum, Brian/0000-0003-0692-1962 FU Military Amputee Research Program FX The authors thank the Military Amputee Research Program for support of this project. NR 20 TC 6 Z9 7 U1 0 U2 3 PU AMER PHYSICAL THERAPY ASSOC PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD DEC PY 2008 VL 88 IS 12 BP 1568 EP 1577 DI 10.2522/ptj.20070337 PG 10 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA 381PU UT WOS:000261549200015 PM 18849481 ER PT J AU Buller, MJ Latzka, WA Yokota, M Tharion, WJ Moran, DS AF Buller, Mark J. Latzka, William A. Yokota, Miyo Tharion, William J. Moran, Daniel S. TI A real-time heat strain risk classifier using heart rate and skin temperature SO PHYSIOLOGICAL MEASUREMENT LA English DT Article DE heat strain classification; real-time physiological monitoring; physiological strain index; heart rate and skin temperature; risk-based classification ID EXERCISE; STRESS; HYPERHYDRATION; RESPONSES; TOLERANCE; WOMEN AB Heat injury is a real concern to workers engaged in physically demanding tasks in high heat strain environments. Several real-time physiological monitoring systems exist that can provide indices of heat strain, e. g. physiological strain index ( PSI), and provide alerts to medical personnel. However, these systems depend on core temperature measurement using expensive, ingestible thermometer pills. Seeking a better solution, we suggest the use of a model which can identify the probability that individuals are 'at risk' from heat injury using non-invasive measures. The intent is for the system to identify individuals who need monitoring more closely or who should apply heat strain mitigation strategies. We generated a model that can identify 'at risk' (PSI >= 7.5) workers from measures of heart rate and chest skin temperature. The model was built using data from six previously published exercise studies in which some subjects wore chemical protective equipment. The model has an overall classification error rate of 10% with one false negative error (2.7%), and outperforms an earlier model and a least squares regression model with classification errors of 21% and 14%, respectively. Additionally, the model allows the classification criteria to be adjusted based on the task and acceptable level of risk. We conclude that the model could be a valuable part of a multifaceted heat strain management system. C1 [Buller, Mark J.; Latzka, William A.; Yokota, Miyo; Tharion, William J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, Inst Mil Physiol, IL-52621 Tel Hashomer, Israel. RP Buller, MJ (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM mark.j.buller@us.army.mil NR 21 TC 9 Z9 10 U1 1 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 0967-3334 J9 PHYSIOL MEAS JI Physiol. Meas. PD DEC PY 2008 VL 29 IS 12 BP N79 EP N85 DI 10.1088/0967-3334/29/12/N01 PG 7 WC Biophysics; Engineering, Biomedical; Physiology SC Biophysics; Engineering; Physiology GA 377OK UT WOS:000261260300008 PM 18946156 ER PT J AU Reddy, AS Kalyani, S Kumar, NS Boddu, VM Krishnaiah, A AF Reddy, A. Subba Kalyani, S. Kumar, N. Siva Boddu, Veera M. Krishnaiah, A. TI Dehydration of 1,4-dioxane by pervaporation using crosslinked calcium alginate-chitosan blend membranes SO POLYMER BULLETIN LA English DT Article ID ACETIC ACID MIXTURES; SODIUM ALGINATE; COMPOSITE MEMBRANES; POLY(VINYL ALCOHOL); DIOXANE MIXTURES; AQUEOUS MIXTURES; SEPARATION; WATER; ISOPROPANOL; PERFORMANCE AB Sodium alginate (SA) and chitosan (CS) blended membranes were crosslinked with maleic anhydride (MA) for the separation of 1,4-dioxane/water mixtures at 30 degrees C by pervaporation (PV). The membranes were characterized by Fourier transform infrared (FTIR) analysis and Ion Exchange Capacity (IEC) to verify the crosslinking. Thermogravimetric analysis (TGA) and X-ray diffraction (XRD) pattern were used to observe the thermal degradation and crystalline nature of the membrane respectively. The membrane performance was studied by calculating flux, selectivity, and pervaporation separation index. Sorption studies were carried out to evaluate the extent of interaction and degree of swelling of the membranes in pure liquids as well as in binary mixtures. The effects of experimental parameters such as feed composition, membrane thickness, and permeate pressure on separation performance of the crosslinked membranes were determined. The experimental result suggested that the membrane has a good potential for breaking the aqueous azeotrope 1,4-dioxane. C1 [Reddy, A. Subba; Kalyani, S.; Kumar, N. Siva; Krishnaiah, A.] Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Labs, Tirupati 517502, Andhra Pradesh, India. [Boddu, Veera M.] USA, Erdc, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Krishnaiah, A (reprint author), Sri Venkateswara Univ, Dept Chem, Biopolymers & Thermophys Labs, Tirupati 517502, Andhra Pradesh, India. EM abburikrishnaiah@gmail.com RI Dr., Nadavala Siva Kumar /D-5404-2011; swayampakula, kalyani/D-6233-2011 OI Dr., Nadavala Siva Kumar /0000-0003-3210-8254; FU Council of Scientific and Industrial Research (CSIR), New Delhi FX The authors are thankful to the Council of Scientific and Industrial Research (CSIR), New Delhi for financial support. NR 24 TC 14 Z9 14 U1 1 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0170-0839 J9 POLYM BULL JI Polym. Bull. PD DEC PY 2008 VL 61 IS 6 BP 779 EP 790 DI 10.1007/s00289-008-1003-x PG 12 WC Polymer Science SC Polymer Science GA 382BL UT WOS:000261579700012 ER PT J AU Qiu, JJ Li, J Zhang, C Liang, R Lin, SS Wang, B Walsh, S AF Qiu, Jingjing Li, Jing Zhang, Chuck Liang, Richard Lin, Shui-Shun Wang, Ben Walsh, Shawn TI Influence of Alcohol Pre-Infusion on the Quality of VARTM Composites SO POLYMER COMPOSITES LA English DT Article ID TRANSFER MOLDING PROCESS/; FLOW; SIMULATION; MODEL; RTM AB In the vacuum assisted resin transfer molding (VARTM) process, part-to-part variations such as the uncertainty in the permeability and race tracking phenomenon make it difficult to achieve consistent mold filling and ensure part quality of composites. Alcohol pre-infusion was presented in this study as a novel real-time monitoring and control approach for the flow process in the VARTM process, alcohol test fluid is infused before the actual resin infusion to locate the potential dry spots without using the large quantity of sensors. Then corresponding process control strategy is designed, such as opening the auxiliary gate at specific moment on those predicted dry spot locations to compensate flow defects. Moreover, alcohol can be easily removed by heat without changing the local permeability. The influence of alcohol pre-infusion on the quality of VARTM composites were investigated in this study. The mechanical tests were conducted to verify that the alcohol pre-infusion approach has no significant effect on composite properties because alcohol can be removed from fiber by heat and air flow. Specifically, DMA, TGA, and FTIR spectrum proved that negligible difference existed on the resin-fiber interface between the composites with or without alcohol pre-infusion. Finally, the microscopy results revealed a similar failure path in a resin matrix. TMA results also demonstrated similar dimension stability. This alcohol pre-infusion approach was effective when compared with computer simulation and could eliminate the occurrence of dry spots and voids without using sensors or data-acquisition system. The control schemes were shown in a case study to be capable of compensating the flow defects and achieving desired fill patterns in the face of permeability uncertainty. POLYM. COMPOS., 29:1310-1320, 2008. (C) 2008 Society of Plastics Engineers C1 [Qiu, Jingjing; Li, Jing; Zhang, Chuck; Liang, Richard; Lin, Shui-Shun; Wang, Ben] Florida State Univ, Florida A&M Univ, High Performance Mat Inst, Dept Ind & Mfg Engn,Coll Engn, Tallahassee, FL 32310 USA. [Walsh, Shawn] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, C (reprint author), Florida State Univ, Florida A&M Univ, High Performance Mat Inst, Dept Ind & Mfg Engn,Coll Engn, Tallahassee, FL 32310 USA. EM chzhang@eng.fsu.edu RI Qiu, Jingjing/E-9248-2015 OI Qiu, Jingjing/0000-0001-9643-5452 FU Army Research Laboratory; Office of Naval Research; Siemens Power Generation; National Science Foundation [0224612] FX This research work has been supported by Army Research Laboratory, Office of Naval Research, Siemens Power Generation, and National Science Foundation I/UCRC Program (Award #: 0224612). NR 17 TC 0 Z9 0 U1 1 U2 10 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0272-8397 J9 POLYM COMPOSITE JI Polym. Compos. PD DEC PY 2008 VL 29 IS 12 BP 1310 EP 1320 DI 10.1002/pc.20514 PG 11 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA 377BV UT WOS:000261227600005 ER PT J AU Calvano, TP Sill, JM Kemp, KR Chung, KK AF Calvano, Tatjana P. Sill, Joshua M. Kemp, Kenneth R. Chung, Kevin K. TI Use of a High-Flow Oxygen Delivery System in a Critically Ill Patient With Dementia SO RESPIRATORY CARE LA English DT Article DE high-flow oxygen; palliative care; hypoxemia ID CARE-ASSOCIATED PNEUMONIA; OBSTRUCTIVE PULMONARY-DISEASE; COMMUNITY-ACQUIRED PNEUMONIA; NASAL CANNULA; INDUCED ASTHMA; EXERCISE; EPIDEMIOLOGY; VENTILATION; OUTCOMES; O2 AB We used a high-flow nasal cannula with a patient who required a high fraction of inspired oxygen but could not tolerate a nasal or facial mask. We saw a 92-year-old woman with delirium and dementia in the intensive care unit for multi-lobar pneumonia with severe hypoxemia. Attempts to oxygenate the patient failed because she was unable to tolerate various facial and nasal masks. We then tried a high-flow nasal cannula (Vapotherm 2000i), which she tolerated well, and she had marked improvement in gas exchange and quality of life. The patient had severe health-care-associated pneumonia, accompanied by delirium and hypoxemia. It became apparent that the patient's death was imminent, and the goal of therapy was palliative. She had previously clearly expressed a desire not to undergo intubation and mechanical ventilation. In a situation where the patient was agitated and unable to tolerate a mask, the high-flow cannula reduced her agitation and improved her dyspnea, oxygenation, tolerance of oxygen therapy, and comfort at the end of life. Oxygen via high-flow cannula may enhance quality of life by reducing hypoxemia in patients who are unable to tolerate a mask but need a high oxygen concentration. C1 [Calvano, Tatjana P.] Brooke Army Med Ctr, Dept Internal Med, Ft Sam Houston, TX 78234 USA. [Sill, Joshua M.; Kemp, Kenneth R.] Brooke Army Med Ctr, Dept Pulm Med, Ft Sam Houston, TX 78234 USA. [Chung, Kevin K.] Brooke Army Med Ctr, Burn Ctr, Ft Sam Houston, TX 78234 USA. RP Calvano, TP (reprint author), Brooke Army Med Ctr, Dept Internal Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM tatjana.calvano@amedd.army.mil NR 28 TC 11 Z9 11 U1 2 U2 2 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD DEC PY 2008 VL 53 IS 12 BP 1739 EP 1743 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 381BZ UT WOS:000261511100017 PM 19025711 ER PT J AU Rosenstein, JE AF Rosenstein, Judith E. TI Individual threat, group threat, and racial policy: Exploring the relationship between threat and racial attitudes SO SOCIAL SCIENCE RESEARCH LA English DT Article; Proceedings Paper CT 101st Annual Meeting of the American-Sociological-Association CY AUG 11-14, 2006 CL Montreal, CANADA SP Amer Sociol Assoc DE racial threat; prejudice; racial attitudes ID PUBLIC-OPINION; SYMBOLIC RACISM; GROUP POSITION; AFFIRMATIVE-ACTION; PERCEIVED THREAT; WESTERN-EUROPE; UNITED-STATES; LABOR-MARKET; PREJUDICE; SOUTH AB Racial threat scholars have long argued that racial prejudice is motivated by threat. This literature identifies two types of threat: individual threat and group threat; however, actual arguments tend to focus on only one of the two types of threat. Consequently, there has been no assessment of whether both threats are simultaneously associated with prejudice. This paper uses data from the 1994 General Social Survey (GSS) to examine the relationship between perceptions of individual threat, perceptions of group threat, and opposition to policies aiding blacks. Results from multinomial logits demonstrate that both threats are associated with opposition to race-equalizing policies, suggesting that single-threat theories should be reevaluated and that studies incorporating racial threat should include both types of threat. (c) 2008 Elsevier Inc. All rights reserved. C1 US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Rosenstein, JE (reprint author), US Mil Acad, Dept Behav Sci & Leadership, 601 Cullum Rd, West Point, NY 10996 USA. EM jer33@cornell.edu NR 59 TC 15 Z9 15 U1 1 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0049-089X J9 SOC SCI RES JI Soc. Sci. Res. PD DEC PY 2008 VL 37 IS 4 BP 1130 EP 1146 DI 10.1016/j.ssresearch.2008.04.001 PG 17 WC Sociology SC Sociology GA 355BY UT WOS:000259685100006 PM 19227695 ER PT J AU Grujicic, M Pandurangan, B Courtis, N Cheeseman, BA Roy, WN Skaggs, RR AF Grujicic, M. Pandurangan, B. Courtis, N. Cheeseman, B. A. Roy, W. N. Skaggs, R. R. TI Computer-simulations based development of a high strain-rate, large-deformation, high-pressure material model for STANAG 4569 sandy gravel SO SOIL DYNAMICS AND EARTHQUAKE ENGINEERING LA English DT Article DE Sandy gravel; Material model; STANAG 4569 ID STRENGTH; SOILS AB The NATO Standard Agreement [STANAG 4569, Protection for occupants of logistics and light-armored vehicles] defines the make-up and the conditions of sandy-gravel soil which is used for testing the ability of various armor systems to provide the necessary level of protection. In this paper. all effort is made to develop it high strain-rate, large-strain, high-pressure material model for sandy gravel which can be used in transient non-linear dynamic simulations of the interactions between landmine detonation gaseous products. landmine-casing fragments and soil ejecta and the target military vehicles. The material model for sandy gravel has been developed by extending the CU-ARL sand model [Grujicic M, Pandurangan B, Cheeseman BA, Roy WN, Skaggs RR, Gupta R. Parameterization of the porous-material model for sand with various degrees of water Saturation. Soil Dyn Earthquake Eng 2008,28(1):20-35] in order to include the effects of gravel particles on the equation of state. strength. failure and erosion behavior. Parametrization of the sandy gravel soil model has been done by carrying out a series of computational experiments pertaining to the deformation and fracture behavior of the two-phase (sand plus gravel) material. Experimental tests which should be carried out in order to validate the proposed model have been identified and described. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Grujicic, M.; Pandurangan, B.; Courtis, N.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Roy, W. N.; Skaggs, R. R.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU US Army/Clemson University Cooperative Agreements [W91 1NF-04-2-0024, W91 1NF-06-20042]; US Army [DAAD19-01-10661] FX The material presented in this paper is based on work supported by the US Army/Clemson University Cooperative Agreements W91 1NF-04-2-0024 and W91 1NF-06-20042 and by the US Army Grant number DAAD19-01-10661. The authors are indebted to Dr. Fred Stanton for the support and a continuing interest in the present work. NR 27 TC 13 Z9 13 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0267-7261 J9 SOIL DYN EARTHQ ENG JI Soil Dyn. Earthq. Eng. PD DEC PY 2008 VL 28 IS 12 BP 1045 EP 1062 DI 10.1016/j.soildyn.2007.11.008 PG 18 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 373XP UT WOS:000261007100009 ER PT J AU Nelson, JD Richard, RL Barillo, DJ Quick, CD Hedman, TL Wolf, S AF Nelson, Joy D. Richard, Reginald L. Barillo, David J. Quick, Charles D. Hedman, Travis L. Wolf, Steven TI Regaining Function, Improving Life SO SOUTHERN MEDICAL JOURNAL LA English DT Meeting Abstract C1 [Nelson, Joy D.; Richard, Reginald L.; Barillo, David J.; Quick, Charles D.; Hedman, Travis L.; Wolf, Steven] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD DEC PY 2008 VL 101 IS 12 BP S30 EP S30 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 384XT UT WOS:000261778200032 ER PT J AU Ashman, CR Pennington, G AF Ashman, Christopher R. Pennington, Gary TI Nitrogen adsorption phases on the 4H-SiC(0001) Si-face SO SURFACE SCIENCE LA English DT Article DE Density functional calculations; Chemisorption; Growth; Interface states; Surface structure; SiC; Nitrogen ID 4H-SIC/SIO2 INTERFACE; CONDUCTION-BAND; SURFACES; DENSITY; PASSIVATION; OXYNITRIDES; GENERATION; OXIDATION; STATES; LAYERS AB Using the density functional theory this paper identifies two phases of nitrogen which form on the 4H-SiC(0001) Si-face. At 1/3 ML, N-adatoms occupy the sites between three surface silicon atoms bonding to each of the three available half-filled silicon dangling bonds. This passivates the surface dangling bonds and removes states from the upper half of the band gap. Above this coverage nitrogen atoms pair on the surface to form dimers with a corresponding. change in the chemical potential. The nitrogen dimers reintroduce states into the SiC band gap. Between 1/3 ML and 1 ML coverage, the nitrogen redistributes in patches corresponding to regions of 1/3 ML coverage and 1 ML coverage. At 1 ML the nitrogen dimers populate all the silicon dangling bonds, thus forming a new surface phase. Above 1 ML a third bonding configuration appears in which the nitrogen dimers are only a singly bonded to the surface. This configuration saturates at 2 ML. (C) 2008 Elsevier B.V. All rights reserved. C1 [Ashman, Christopher R.] High Performance Technol Inc, Reston, VA 20190 USA. [Pennington, Gary] USA, Res Lab, Adelphi, MD 20783 USA. RP Ashman, CR (reprint author), High Performance Technol Inc, 11955 Freedom Dr,Suite 1100, Reston, VA 20190 USA. EM ashman@nrl.navy.mil FU Department-of Defense High performance Computing Modernization Office FX Simulations were performed on computers at the Army Research Laboratory with the assistance of the PET program of the Department-of Defense High performance Computing Modernization Office. We thank those institutions for their valuable support. NR 31 TC 5 Z9 5 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 EI 1879-2758 J9 SURF SCI JI Surf. Sci. PD DEC 1 PY 2008 VL 602 IS 23 BP 3617 EP 3622 DI 10.1016/j.susc.2008.10.013 PG 6 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA 383UK UT WOS:000261699000010 ER PT J AU Kim, SH Nam, MH Roh, KH Park, HC Nam, DH Park, GH Han, ET Klein, TA Lim, CS AF Kim, Sun Hyung Nam, Myung-Hyun Roh, Kyoung Ho Park, Hae Chul Nam, Deok Hwa Park, Gli Hong Han, Eun Taek Klein, Terry A. Lim, Chae Seung TI Evaluation of a rapid diagnostic test specific for Plasmodium vivax SO TROPICAL MEDICINE & INTERNATIONAL HEALTH LA English DT Article DE Plasmodium vivax; OptiMAL; parasite lactate dehydrogenase; SD Malaria Antigen P; v ID SUSPECTED MALARIA PATIENTS; ANTIGEN-CAPTURE ASSAY; FALCIPARUM-MALARIA; EXPERT MICROSCOPY; GENETIC DIVERSITY; PERFORMANCE AB Plasmodium vivax is the only human malaria indigenous to the Republic of Korea (ROK). A rapid and sensitive diagnostic test (RDT) that detects P. vivax is appropriate for evaluating suspected malaria patients with no travel history abroad. The RDTs, SD Malaria Antigen P.v (SD diagnostic, Kyonggi, ROK) specific for P. vivax and the well documented OptiMAL (DiaMed, Cressier, Switzerland) were compared among 282 volunteers for specificity and sensitivity of P. vivax and Plasmodium falciparum malaria infections against Giemsa-stained blood smears read by an experienced microscopist. A total of 137 volunteers were diagnosed with P. vivax, 45 cases (returned travellers from overseas) were diagnosed with P. falciparum and 100 healthy volunteers were diagnosed as negative for malaria. Correspondingly, the SD Malaria Antigen P.v test identified P. vivax infections in 128/137 malaria patients (93.4%) and 0/100 (0%) healthy volunteers. Three patients identified with P. falciparum also were interpreted as P. vivax by the SD Malaria Antigen P.v test; however, these patients were later confirmed as mixed infections of P. vivax and P. falciparum by polymerase chain reaction. OptiMAL interpreted the three mixed infections only as P. falciparum and detected 130/137 (94.9%) patients with P. vivax. The sensitivity of the SD Malaria Antigen P.v test decreased from 100% (> 5000 parasite/mu l) to 81.3% (1-100 parasites/mu l) as parasitaemia levels declined. For the regions where P. vivax is the primary malaria parasite, the SD P. vivax-specific rapid diagnostic test may be useful for screening suspected malaria patients when sufficient material and human resources (e.g. trained microscopists) are unavailable for malaria diagnosis. C1 [Kim, Sun Hyung; Nam, Myung-Hyun; Roh, Kyoung Ho; Nam, Deok Hwa; Lim, Chae Seung] Korea Univ, Coll Med, Dept Lab Med, Seoul 136705, South Korea. [Roh, Kyoung Ho] Konyang Univ, Coll Med, Dept Lab Med, Taejon, South Korea. [Park, Hae Chul] Korea Univ, Coll Med, Neurophysiol Lab, Seoul 136705, South Korea. [Park, Gli Hong] Korea Univ, Coll Med, Dept Biochem, Seoul 136705, South Korea. [Han, Eun Taek] Kangwon Univ, Coll Med, Dept Parasitol, Chunchon, Kangwon Prov, South Korea. [Klein, Terry A.] US Army, Med Command 18, Seoul, South Korea. RP Lim, CS (reprint author), Korea Univ, Ansan Hosp, Coll Med, Dept Lab Med, 516 Gojan Dong, Ansan 425707, Gyeonggi Prov, South Korea. EM malarim@korea.ac.kr FU Korea University Medical Center; Seoul R BD program FX The authors would like to thank Dr Dae Won Park and In Keun Choi at the Korea university Ansan hospital. The authors are grateful for the cooperation of the non-malaria and malaria patients who volunteered for this study. This work was supported by the U-health program of the Korea University Medical Center, Seoul R & BD program (2007). SD Malaria Antigen P. v and SD Malaria Antigen P.f kits were donated for evaluation by SD Diagnostic Corporation. NR 26 TC 12 Z9 12 U1 1 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1360-2276 J9 TROP MED INT HEALTH JI Trop. Med. Int. Health PD DEC PY 2008 VL 13 IS 12 BP 1495 EP 1500 DI 10.1111/j.1365-3156.2008.02163.x PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 376UW UT WOS:000261209500010 PM 18983278 ER PT J AU Le Fer, D Fraser, JD Kruse, CD AF Le Fer, Danielle Fraser, James D. Kruse, Casey D. TI Piping Plover Foraging-Site Selection on the Missouri River SO WATERBIRDS LA English DT Article DE Charadrius melodus; epilimnetc; foraging; habitat; hypolimnetic; Missouri River; Piping Plover; shorebird ID MISSISSIPPI RIVER; HABITAT USE; SURVIVAL; ISLANDS AB Selection of a foraging site entails costs and benefits which are reflected in survival and reproductive success. We studied Piping Plover (Charadrius melodus) foraging-site selection during the breeding season (2001-2003) On the Missouri River and examined the relationship between site selection and invertebrate abundance indices within habitats. Foraging adult plovers selected protected shoreline (inter-sandbar channels, inlets, and backwater areas) more often than expected based on availability (use: 92% +/- 3%; availability: 58% +/- 5%). Invertebrate biomass and numbers along exposed shoreline did not. differ among reaches. Along the protected shoreline, invertebrate biomass and numbers were higher below a dam with an epilimnetic release and a relatively constant release rate (epilimnetic reach) than at the other two reaches. On the epilimnetic river reach, invertebrate biomass and numbers were higher along the protected shoreline than on the main channel shoreline. On a reach below a dam with a hypolimnetic release and diel flow pulse (hypolimnetic reach) and a cold water reservoir, invertebrate indices were similar on the protected and exposed shoreline. Invertebrate numbers were higher in saturated and moist habitats than in vegetated and dry habitats (P < 0.05). At the epilimnetic and hypolimnetic reaches, foraging Piping Plover chicks used saturated and moist habitats more than vegetated and dry habitats, based on availability. On the Missouri River, protected shorelines were important foraging sites for Piping Plovers during the breeding season, and sandbars with low-lying moist habitat were important to foraging chicks. Piping Plovers will benefit from increased availability of these habitats on managed or created sandbars on the Missouri River. Received 9 September 2007, accepted June 2008. C1 [Le Fer, Danielle; Fraser, James D.] Virginia Tech, Dept Fisheries & Wildlife Sci, Blacksburg, VA 24061 USA. [Kruse, Casey D.] USA, Corps Engineers, Yankton, SD 57078 USA. RP Le Fer, D (reprint author), San Francisco Bay Bird Observ, 524 Valley Way, Milpitas, CA 95035 USA. EM dlefer@sfbbo.org FU U.S. Army Corps of Engineers; U.S. Fish and Wildlife Service; South Dakota Department of Fish and Game FX We thank the U.S. Army Corps of Engineers, U.S. Fish and Wildlife Service, and South Dakota Department of Fish and Game for their funding. Special thanks to the inany technicians who helped NNrith the research. NR 22 TC 9 Z9 10 U1 2 U2 8 PU WATERBIRD SOC PI WASHINGTON PA NATL MUSEUM NATURAL HISTORY SMITHSONIAN INST, WASHINGTON, DC 20560 USA SN 1524-4695 J9 WATERBIRDS JI Waterbirds PD DEC PY 2008 VL 31 IS 4 BP 587 EP 592 PG 6 WC Ornithology SC Zoology GA 401II UT WOS:000262934000009 ER PT J AU Yeh, IC Lee, MS Olson, MA AF Yeh, In-Chul Lee, Michael S. Olson, Mark A. TI Calculation of Protein Heat Capacity from Replica-Exchange Molecular Dynamics Simulations with Different Implicit Solvent Models SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID GENERALIZED BORN MODEL; HISTOGRAM ANALYSIS METHOD; FREE-ENERGY LANDSCAPE; CENTERED DIELECTRIC FUNCTIONS; ALPHA-HELICAL PEPTIDES; EXPLICIT SOLVENT; SH3 DOMAIN; FOLDING KINETICS; BETA-HAIRPIN; SOLVATION AB The heat capacity has played a major role in relating microscopic and macroscopic properties of proteins and their disorder-order phase transition of folding. Its calculation by atomistic simulation methods remains a significant challenge due to the complex and dynamic nature of protein structures, their solvent environment, and configurational averaging. To better understand these factors on calculating a protein heat capacity, we provide a comparative analysis of simulation models that differ in their implicit solvent description and force-field resolution. Our model protein system is the src Homology 3 (SH3) domain of alpha-spectrin, and we report a series of 10 ns replica-exchange molecular dynamics simulations performed at temperatures ranging from 298 to 550 K, starting from the SH3 native structure. We apply the all-atom CHARMM22 force field with different modified analytical generalized Born solvent models (GBSW and GBMV2) and compare these simulation models with the distance-dependent dielectric screening of charge-charge interactions. A further comparison is provided with the united-atom CHARMM19 plus a pairwise GB model. Unfolding-folding transition temperatures of SH3 were estimated from the temperature-dependent profiles of the heat capacity, root-mean-square distance from the native structure, and the fraction of native contacts, each calculated from the density of states by using the weighted histogram analysis method. We observed that, for CHARMM22, the unfolding transition and energy probability density were quite sensitive to the implicit solvent description, in particular, the treatment of the protein-solvent dielectric boundary in GB models and their surface-area-based hydrophobic term. Among the solvent models tested, the calculated melting temperature varied in the range 353-438 K and was higher than the experimental value near 340 K. A reformulated GBMV2 model of employing a smoother molecular-volume dielectric interface was the most accurate in reproducing the native conformation and a two-state folding landscape, although the melting transition temperature did not show the smallest deviation from experiment. For the lower-resolution CHARMM19/GB model, the simulations failed to yield a bimodal energy distribution, yet the melting temperature was observed to be a good estimate of higher-resolution simulation models. We also demonstrate that a careful analysis of a relatively long simulation is necessary to avoid trapping in local minima and to find a true thermodynamic transition temperature. C1 [Lee, Michael S.; Olson, Mark A.] USA, Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Ft Detrick, MD 21702 USA. [Yeh, In-Chul; Lee, Michael S.] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Frederick, MD 21702 USA. [Lee, Michael S.] USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Olson, MA (reprint author), USA, Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Ft Detrick, MD 21702 USA. EM molson@ncifcrf.gov FU Department of Defense High Performance Computing (HPC) Modernization Program Office [21248, 132259] FX Acknowledgment. We thank Dr. M. Feig and Dr. A. Wallqvist for helpful discussions, and also Dr. E. Gallicchio and Dr. R. Levy for making their software code available to us for estimating statistical uncertainties. Funding support for this work came from the Department of Defense High Performance Computing (HPC) Modernization Program Office, under the HPC Software Application Institute initiative, and the Army Medical Research and Materiel Command (Project Nos. 21248 and 132259). Computational time was provided by the U.S. Army Research Laboratory Major Shared Resource Center and the Advanced Biomedical Computing Center at the National Cancer Institute. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 61 TC 20 Z9 20 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD NOV 27 PY 2008 VL 112 IS 47 BP 15064 EP 15073 DI 10.1021/jp802469g PG 10 WC Chemistry, Physical SC Chemistry GA 374PO UT WOS:000261056400047 PM 18959439 ER PT J AU Liu, CH He, HY Pandey, R Hussain, S Karna, SP AF Liu, Chunhui He, Haiying Pandey, Ravindra Hussain, Saber Karna, Shashi P. TI Interaction of Metallic Nanoparticles with a Biologically Active Molecule, Dopamine SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID AUGMENTED-WAVE METHOD; AQUEOUS-SOLUTION; CLUSTERS; NANOMATERIALS; CONFORMATION; DYNAMICS AB We present the results of first-principles molecular orbital calculations describing the interaction of metallic nanoparticles, represented by Mn-13, Ag-13, and Al-13 atomic clusters, with a biologically active molecule, dopamine. The interaction strength, determined in terms of the nanoparticle-molecule complex binding energy, is found to be higher for Mn than either Ag or Al and can be explained in terms of the degree of the hybridization of the (metal) atomic orbitals with the molecular orbitals in the complex. Furthermore, smaller interaction strength of these metallic nanoparticles with water compared to that with dopamine predicts the preference of forming a complex of dopamine with the metallic nanoparticles in the aqueous solution. The calculated results may therefore suggest that the presence of these metallic nanoparticles could induce different levels of dopamine depletion in solution. C1 [Liu, Chunhui; He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Liu, Chunhui; He, Haiying; Pandey, Ravindra] Michigan Technol Univ, Multiscale Technol Inst, Houghton, MI 49931 USA. [Hussain, Saber] USAF, Res Lab, Dayton, OH USA. [Karna, Shashi P.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu FU DARPA [ARL-DAAD 17-03-C-0115] FX Helpful discussions with R. Scheicher, S. Gowtham, and K. C. Lau are acknowledged. The work at Michigan Technological University was supported by DARPA (contract No. ARL-DAAD 17-03-C-0115). NR 29 TC 9 Z9 10 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD NOV 27 PY 2008 VL 112 IS 47 BP 15256 EP 15259 DI 10.1021/jp808009t PG 4 WC Chemistry, Physical SC Chemistry GA 374PO UT WOS:000261056400068 PM 18983187 ER PT J AU Neff, RT Hurst, FP Falta, EM Bohen, EM Lentine, KL Dharnidharka, VR Agodoa, LY Jindal, RM Yuan, CM Abbott, KC AF Neff, Robert T. Hurst, Frank P. Falta, Edward M. Bohen, Erin M. Lentine, Krista L. Dharnidharka, Vikas R. Agodoa, Lawrence Y. Jindal, Rahul M. Yuan, Christina M. Abbott, Kevin C. TI Progressive Multifocal Leukoencephalopathy and Use of Mycophenolate Mofetil After Kidney Transplantation SO TRANSPLANTATION LA English DT Article DE Kidney transplant; Mycophenolate mofetil; Progressive multifocal leukoencephalopathy ID VIRUS VP1 POLYPEPTIDES; RENAL-TRANSPLANTATION; BK VIRUS; RECIPIENT; NEPHROPATHY; PATIENT; DISEASE; PML AB Mycophenolate mofetil (MMF) use may be associated with progressive multifocal leukoencephalopathy (PML). We conducted a retrospective cohort study of 32,757 renal transplant recipients using the United States Renal Data System kidney transplant files for the incidence, prognosis, and clinical features associated with PML Occurring after kidney transplant. Subjects were transplanted from January 1, 2000 to July 31, 2004 and followed through December 31, 2004. The incidence density of PML in MMF users was 14.4 cases/100,000 person-years at risk versus 0 for non-MMF users (P=0.11) by log rank test. Factors significantly associated with PML were BK virus infection (22.2% vs. 1.1%), pretransplant transfusion (75% vs. 34%), panel reactive antibody more than 20% (56% vs. 14%), and use of antirejection medications in the first year (33% vs. 9.2%), all P less than 0.05. PML is rare in the renal transplant population. There was no significant association between PML and MMF, but MMF use in this cohort is too high to accurately assess an association. C1 [Neff, Robert T.; Hurst, Frank P.; Bohen, Erin M.; Yuan, Christina M.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Falta, Edward M.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. [Lentine, Krista L.] St Louis Univ, Sch Med, Ctr Outcomes Res, Div Nephrol, St Louis, MO USA. [Dharnidharka, Vikas R.] Univ Florida, Coll Med, Dept Pediat, Gainesville, FL USA. [Agodoa, Lawrence Y.] NIDDKD, NIH, Bethesda, MD 20892 USA. [Jindal, Rahul M.] Brookdale Univ Hosp, Dept Surg, Brooklyn, NY USA. RP Neff, RT (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM robert.neff@amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 26 TC 77 Z9 77 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD NOV 27 PY 2008 VL 86 IS 10 BP 1474 EP 1478 DI 10.1097/TP.0b013e31818b62c8 PG 5 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 377XL UT WOS:000261285600023 PM 19034021 ER PT J AU Klein, RJ Cole, SM Belcher, ME Schroeder, JL Cole, PJ Lenhart, JL AF Klein, Robert J. Cole, Shannon M. Belcher, Michael E. Schroeder, John L. Cole, Phillip J. Lenhart, Joseph L. TI Radiation tolerance in polymeric dielectrics by small-molecule doping, Part I: Dopant uptake as a function of temperature, time, and chemistry SO POLYMER LA English DT Article DE Radiation; Polymer; Conductivity ID INDUCED CONDUCTIVITY; POLYETHYLENE TEREPHTHALATE; HETEROGENEOUS SYSTEMS; SORPTION-DIFFUSION; ELECTRON-TRANSPORT; AMORPHOUS POLYMERS; FILMS; ADSORPTION; BATTERIES; MEMBRANES AB The doping of Mylar (R) film (composed of semi-crystalline poly(ethylene terephthalate)) with small-molecule electron traps results in a high-quality dielectric film with excellent radiation tolerance. This paper, the first of two, investigates the doping process as small molecules are implanted into the film from a solution of ethylene glycol over time. A series of fluorenone-based dopants are investigated, functionalized by nitro or cyano groups. The concentration of dopant in the Mylar (R) is a strong function of time, temperature, and solution concentration. Doping is ineffective below the glass transition temperature of the polymer. The chemical functionality of the dopant had a strong effect on the doping process, with additional nitro or cyano groups leading to enhanced film concentrations. (C) 2008 Published by Elsevier Ltd. C1 [Cole, Phillip J.] Sandia Natl Labs, NNSA Satellite Programs 5732, Albuquerque, NM 87185 USA. [Klein, Robert J.; Schroeder, John L.; Lenhart, Joseph L.] Sandia Natl Labs, Organ Mat Dept 1821, Albuquerque, NM 87185 USA. [Cole, Shannon M.; Belcher, Michael E.] Sandia Natl Labs, Organ Mat Dept 2453, Albuquerque, NM 87185 USA. [Lenhart, Joseph L.] USA, Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Cole, PJ (reprint author), Sandia Natl Labs, NNSA Satellite Programs 5732, POB 5800, Albuquerque, NM 87185 USA. EM pjcole@sandia.gov; joseph.lenhart1@arl.army.mil FU Sandia Corporation; Lockheed Martin Company; United States Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Thanks to Mark Stavig for his assistance with the DSC and DMA. NR 44 TC 2 Z9 4 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD NOV 24 PY 2008 VL 49 IS 25 BP 5541 EP 5548 DI 10.1016/j.polymer.2008.08.067 PG 8 WC Polymer Science SC Polymer Science GA 380JU UT WOS:000261462800024 ER PT J AU Weiss, BM Verma, P Abadie, J Howard, R Kuehl, M AF Weiss, Brendan M. Verma, Pramvir Abadie, Jude Howard, Robin Kuehl, Michael TI A Pre-Existing Plasma Cell Disorder Occurs in Most Patients with Multiple Myeloma SO BLOOD LA English DT Meeting Abstract CT 50th Annual Meeting of the American-Society-of-Hematology CY DEC 06-09, 2008 CL San Francisco, CA SP Amer Soc Hematol C1 [Weiss, Brendan M.] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. [Verma, Pramvir] Womack Army Med Ctr, Hematol Oncol Serv, Ft Bragg, NC USA. [Abadie, Jude] Walter Reed Army Med Ctr, Pathol & Area Lab Serv, Washington, DC 20307 USA. [Howard, Robin] Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. [Kuehl, Michael] Natl Canc Inst, Genet Branch, Ctr Canc Res, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 16 PY 2008 VL 112 IS 11 BP 598 EP 598 PG 1 WC Hematology SC Hematology GA 389OP UT WOS:000262104702027 ER PT J AU Okatan, MB Cole, MW Alpay, SP AF Okatan, M. B. Cole, M. W. Alpay, S. P. TI Dielectric tunability of graded barium strontium titanate multilayers: Effect of thermal strains SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE barium compounds; ferroelectric materials; multilayers; numerical analysis; permittivity; strontium compounds; tensile strength; thermal expansion; thermodynamics ID FERROELECTRIC THIN-FILMS; PHASE-TRANSITIONS; TECHNOLOGY; COMPONENTS; PARAMETER; DIAGRAMS; STRESSES; SRTIO3 AB A thermodynamic model was developed to analyze the effect of the difference in the thermal expansion coefficient (TEC) of a multilayered barium strontium titanate Ba1-ySryTiO3 (BST) ferroelectric heterostructure and a passive substrate on the dielectric properties by taking into account electrostatic and electromechanical interactions between the ferroelectric layers. Results show that the dielectric constant and tunability can be maximized by minimizing the TEC mismatch. Furthermore, lower processing temperatures lead to lower thermal strains and thus to better dielectric properties. We also provide a numerical analysis describing the effect of thermal strains on dielectric properties of a compositionally graded trilayer consisting of BST 60/40, BST 75/25, and BST 90/10 on a variety of substrates including Si, sapphire (alpha-Al2O3), SrTiO3, MgO, and LaAlO3. The multilayer BST heterostructure on Si is expected to experience high in-plane tensile strains due to the large TEC mismatch, resulting in dielectric permittivities and tunabilities lower compared to the same multilayer on SrTiO3 or LaAlO3 for which there is a better TEC match. For BST multilayers on MgO, SrTiO3, Si, and sapphire, higher processing temperatures lead to lower dielectric response and tunability. C1 [Okatan, M. B.; Alpay, S. P.] Univ Connecticut, Mat Sci & Engn Program, Dept Chem Mat & Biomol Engn, Storrs, CT 06269 USA. [Okatan, M. B.; Alpay, S. P.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Cole, M. W.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Alpay, SP (reprint author), Univ Connecticut, Mat Sci & Engn Program, Dept Chem Mat & Biomol Engn, Storrs, CT 06269 USA. EM mcole@arl.army.mil; p.alpay@ims.uconn.edu RI Alpay, Pamir/E-2666-2013; Okatan, M. Baris/E-1913-2016 OI Okatan, M. Baris/0000-0002-9421-7846 FU U. S. Army Research Office [W911NF-05-1-0528, W911NF-08-C-0124] FX The work at UConn was supported by the U. S. Army Research Office through Grant Nos. W911NF-05-1-0528 and W911NF-08-C-0124. NR 34 TC 29 Z9 29 U1 6 U2 30 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 15 PY 2008 VL 104 IS 10 AR 104107 DI 10.1063/1.3026719 PG 7 WC Physics, Applied SC Physics GA 396QI UT WOS:000262605800110 ER PT J AU Sandstrom, E Nilsson, C Hejdeman, B Brave, A Bratt, G Robb, M Cox, J VanCott, T Marovich, M Stout, R Aboud, S Bakari, M Pallangyo, K Ljungberg, K Moss, B Earl, P Michael, N Birx, D Mhalu, F Wahren, B Biberfeld, G AF Sandstrom, Eric Nilsson, Charlotta Hejdeman, Bo Brave, Andreas Bratt, Goran Robb, Merlin Cox, Josephine VanCott, Thomas Marovich, Mary Stout, Richard Aboud, Said Bakari, Muhammad Pallangyo, Kisali Ljungberg, Karl Moss, Bernard Earl, Patricia Michael, Nelson Birx, Deborah Mhalu, Fred Wahren, Britta Biberfeld, Gunnel CA HIV Immunogenicity Study 01 02 Tea TI Broad Immunogenicity of a Multigene, Multiclade HIV-1 DNA Vaccine Boosted with Heterologous HIV-1 Recombinant Modified Vaccinia Virus Ankara SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 6th Annual International AIDS Vaccine Conference CY AUG 20-23, 2007 CL Seattle, WA ID CD8(+) T-CELL; COLONY-STIMULATING FACTOR; HEPATITIS-B VACCINATION; CANDIDATE VACCINE; IMMUNE-RESPONSES; PHASE-1 SAFETY; AIDS RESEARCH; EPITOPES; REGIMEN; CLADE AB Background. A human immunodeficiency virus (HIV) vaccine that limits disease and transmission is urgently needed. This clinical trial evaluated the safety and immunogenicity of an HIV vaccine that combines a plasmid-DNA priming vaccine and a modified vaccinia virus Ankara (MVA) boosting vaccine. Methods. Forty healthy volunteers were injected with DNA plasmids containing gp160 of HIV-1 subtypes A, B, and C; rev B; p17/p24 gag A and B, and RTmut B by use of a needle-free injection system. The vaccine was administered intradermally or intramuscularly, with or without recombinant granulocyte macrophage colony-stimulating factor, and boosted with a heterologousMVAcontaining env, gag, and pol of CRF01A_ E. Immune responses were monitored with HIV-specific interferon (IFN)-gamma and interleukin (IL)-2 ELISpot and lymphoproliferative assays (LPAs). Results. Vaccine-related adverse events were mild and tolerable. After receipt of the DNA priming vaccine, 11 (30%) of 37 vaccinees had HIV-specific IFN-gamma responses. After receipt of the MVA boosting vaccine, ELISpot assays showed that 34 (92%) of 37 vaccinees had HIV-specific IFN-gamma responses, 32 (86%) to Gag and 24 ( 65%) to Env. IFN-gamma production was detected in both the CD8(+) T cell compartment ( 5 of 9 selected vaccinees) and the CD4(+) T cell compartment ( 9 of 9). ELISpot results showed that 25 ( 68%) of 37 vaccinees had a positive IL-2 response and 35 ( 92%) of 38 had a positive LPA response. Of 38 subjects, a total of 37 (97%) were responders. One milligram of HIV-1 DNA administered intradermally was as effective as 4mg administered intramuscularly in priming for the MVA boosting vaccine. Conclusion. This HIV-DNA priming-MVA boosting approach is safe and highly immunogenic. C1 [Ljungberg, Karl] Karolinska Inst, Dept Oncol Pathol, S-11883 Stockholm, Sweden. [Nilsson, Charlotta; Brave, Andreas; Wahren, Britta; Biberfeld, Gunnel] Karolinska Inst, Swedish Inst Infect Dis Control, S-11883 Stockholm, Sweden. [Robb, Merlin; Cox, Josephine; VanCott, Thomas; Marovich, Mary; Michael, Nelson; Birx, Deborah] Walter Reed Army Inst Res, Dept Retrovirol, Rockville, MD USA. [Moss, Bernard; Earl, Patricia] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA. [Stout, Richard] Bioject, Portland, OR USA. [Aboud, Said; Bakari, Muhammad; Pallangyo, Kisali; Mhalu, Fred] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Nilsson, Charlotta; Brave, Andreas; Wahren, Britta; Biberfeld, Gunnel] Karolinska Inst, Dept Microbiol & Tumor & Cell Biol, S-11883 Stockholm, Sweden. [Sandstrom, Eric; Hejdeman, Bo; Bratt, Goran] Karolinska Inst, Soder Sjukhuset, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden. RP Wahren, B (reprint author), Karolinska Inst, Soder Sjukhuset, Dept Clin Sci & Educ, S-11883 Stockholm, Sweden. EM Eric.sandstrom@sodersjukhuset.se; Britta.Wahren@smi.ki.se OI Ljungberg, Karl/0000-0001-7192-6204 FU Intramural NIH HHS [Z01 AI000416-25] NR 34 TC 99 Z9 100 U1 2 U2 9 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2008 VL 198 IS 10 BP 1482 EP 1490 DI 10.1086/592507 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 366HW UT WOS:000260472400010 PM 18808335 ER PT J AU Cardoso, MJ Dmitriev, AE Lehman, RA Helgeson, M Cooper, P Rosner, MK AF Cardoso, Mario J. Dmitriev, Anton E. Lehman, Ronald A. Helgeson, Melvin Cooper, Patrick Rosner, Michael K. TI Computed Tomography and Biomechanical Evaluation of Screw Fixation Options at the Cervicothoracic Junction Intralamina Versus Intrapedicular Techniques SO SPINE LA English DT Article DE cervicothoracic junction; lamina screw; pedicle screw; salvage technique ID BONE-MINERAL DENSITY; UPPER THORACIC SPINE; PEDICLE SCREWS; STRAIGHT-FORWARD; PLACEMENT; VERTEBRAE; FAILURE AB Study Design. In vitro cadaveric biomechanical analysis. Objective. Define the T1 and T2 anatomic lamina size and evaluate the bone-screw interface strength of various pedicle screw options and intralamina techniques. Summary of Background Data. Transpedicular instrumentation is well accepted, but salvage techniques in the proximal thoracic spine are limited. Intralamina fixation has been described at C2 with favorable biomechanical characteristics. In addition, this technique has been introduced clinically in the proximal thoracic spine. However, the biomechanical potential has not been evaluated. Methods. Fourteen fresh-frozen cervicothoracic cadaveric specimens were scanned using dual-energy radiograph absorptiometry for bone mineral density, imaged under computed tomography, and then instrumented in the following configuration: (1) Right-sided pedicle screws in a straight-forward trajectory, (2) "salvage anatomic trajectory pedicle screws, and (3) "salvage" intralamina screws into the contralateral lamina. Insertional torque (IT) was recorded with each revolution and screws were pulled out in-line (POS) with the screw axis to simulate intraoperative failure of fixation. Results. Lamina screws as a salvage technique generated statistically greater peak IT (P = 0.002) and relative POS (P < 0.05) in comparison with straight-forward transpedicular screws as the initial fixation type. Furthermore, lamina screws, when compared to the salvage anatomic trajectory pedicle screws, had a significantly greater peak IT (P = 0.011). The peak IT showed a stronger correlation with POS in lamina screws than straight-forward or anatomic pedicle screws with a similar trend noted in mean IT. Bone mineral density correlated with POS in all methods of fixation. The mean lamina width measured on computed tomography at the thinnest point was 5.9 +/- 0.7 mm (range, 4.9-7.9). Conclusion. Our results suggest that lamina screws, used as a salvage technique in the proximal thoracic spine, provide stronger fixation than transpedicular screws when using standard 4.5-mm cervical screws. Intralamina screws appear to be a biomechanically sound salvage technique in the region, and appear to be a safe, effective technique for instrumenting the proximal thoracic spine. C1 [Cardoso, Mario J.; Cooper, Patrick; Rosner, Michael K.] Walter Reed Army Med Ctr, Neurosurg Serv, Dept Surg, Washington, DC 20307 USA. [Dmitriev, Anton E.; Lehman, Ronald A.; Helgeson, Melvin] Walter Reed Army Med Ctr, Dept Orthoped & Rehabil, Washington, DC 20307 USA. RP Cardoso, MJ (reprint author), Walter Reed Army Med Ctr, Neurosurg Serv, Dept Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM mtcardoso@comcast.net NR 19 TC 11 Z9 14 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD NOV 15 PY 2008 VL 33 IS 24 BP 2612 EP 2617 DI 10.1097/BRS.0b013e31818ce3ac PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 373ZG UT WOS:000261011400006 PM 19011542 ER PT J AU Leon, LR AF Leon, Lisa R. TI Thermoregulatory responses to environmental toxicants: The interaction of thermal stress and toxicant exposure SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Review DE Toxicology; Hypothermia; Fever; Heat stress; Organophosphates ID BROWN ADIPOSE-TISSUE; TUMOR-NECROSIS-FACTOR; METAL FUME FEVER; BODY-TEMPERATURE; PERCUTANEOUS-ABSORPTION; INDUCED HYPOTHERMIA; HEAT-STROKE; IN-VITRO; DIISOPROPYL FLUOROPHOSPHATE; CHOLINESTERASE-INHIBITORS AB Thermal stress can have a profound impact on the physiological responses that are elicited following environmental toxicant exposure. The efficacy by which toxicants enter the body is directly influenced by thermoregulatory effector responses that are evoked in response to high ambient temperatures. In mammals, the thermoregulatory response to heat stress consists of an increase in skin blood flow and moistening of the skin surface to dissipate core heat to the environment. These physiological responses may exacerbate chemical toxicity due to increased permeability of the skin, which facilitates the cutaneous absorption of many environmental toxicants. The core temperature responses that are elicited in response to high ambient temperatures, toxicant exposure or both can also have a profound impact on the ability of an organism to survive the insult. In small rodents. the thermoregulatory response to thermal stress and many environmental toxicants (such as organophosphate compounds) is often biphasic in nature, consisting initially of a regulated reduction in core temperature (i.e., hypothermia) followed by fever. Hypothermia is an important thermoregulatory survival stratey that is used by small rodents to diminish the effect of severe environmental insults on tissue homeostasis. The protective effect of hypothermia is realized by its effects on chemical toxicity as molecular and cellular processes, such as lipid peroxidation and the formation of reactive oxygen species, are minimized at reduced core temperatures. The beneficial effects of fever are unknown under these conditions. Perspective is provided on the applicability of data obtained in rodent models to the human condition. Published by Elsevier Inc. C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Leon, LR (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM lisa.r.leon@us.army.mil NR 151 TC 19 Z9 20 U1 1 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD NOV 15 PY 2008 VL 233 IS 1 BP 146 EP 161 DI 10.1016/j.taap.2008.01.012 PG 16 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 380PO UT WOS:000261477800024 PM 18313713 ER PT J AU Mahajan, B Selvapandiyan, A Gerald, NJ Majam, V Zheng, H Wickramarachchi, T Tiwari, J Fujioka, H Moch, JK Kumar, N Aravind, L Nakhasi, HL Kumar, S AF Mahajan, Babita Selvapandiyan, Angamuthu Gerald, Noel J. Majam, Victoria Zheng, Hong Wickramarachchi, Thilan Tiwari, Jawahar Fujioka, Hisashi Moch, J. Kathleen Kumar, Nirbhay Aravind, L. Nakhasi, Hira L. Kumar, Sanjai TI Centrins, Cell Cycle Regulation Proteins in Human Malaria Parasite Plasmodium falciparum SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID SPINDLE POLE BODY; CHLAMYDOMONAS-REINHARDTII; CALCIUM-BINDING; SACCHAROMYCES-CEREVISIAE; LEISHMANIA-DONOVANI; MAXIMUM-LIKELIHOOD; TRYPANOSOMA-BRUCEI; MURINE CENTRIN; GENE; DUPLICATION AB Molecules and cellular mechanisms that regulate the process of cell division in malaria parasites remain poorly understood. In this study we isolate and characterize the four Plasmodium falciparum centrins (PfCENs) and, by growth complementation studies, provide evidence for their involvement in cell division. Centrins are cytoskeleton proteins with key roles in cell division, including centrosome duplication, and possess four Ca2+-binding EF hand domains. By means of phylogenetic analysis, we were able to decipher the evolutionary history of centrins in eukaryotes with particular emphasis on the situation in apicomplexans and other alveolates. Plasmodium possesses orthologs of four distinct centrin paralogs traceable to the ancestral alveolate, including two that are unique to alveolates. By real time PCR and/or immunofluorescence, we determined the expression of PfCEN mRNA or protein in sporozoites, asexual blood forms, gametocytes, and in the oocysts developing inside mosquito mid-gut. Immunoelectron microscopy studies showed that centrin is expressed in close proximity with the nucleus of sporozoites and asexual schizonts. Furthermore, confocal and widefield microscopy using the double staining with alpha-tubulin and centrin antibodies strongly suggested that centrin is associated with the parasite centrosome. Following the episomal expression of the four PfCENs in a centrin knock-out Leishmania donovani parasite line that exhibited a severe growth defect, one of the PfCENs was able to partially restore Leishmania growth rate and overcome the defect in cytokinesis in such mutant cell line. To our knowledge, this study is the first characterization of a Plasmodium molecule that is involved in the process of cell division. These results provide the opportunity to further explore the role of centrins in cell division in malaria parasites and suggest novel targets to construct genetically modified, live attenuated malaria vaccines. C1 [Kumar, Sanjai] US FDA, CBER, DETTD, OBRR, Rockville, MD 20852 USA. [Tiwari, Jawahar] US FDA, Ctr Biol Evaluat & Res, Div Biostat, Rockville, MD 20852 USA. [Fujioka, Hisashi] Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA. [Moch, J. Kathleen] Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. [Kumar, Nirbhay] Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. [Aravind, L.] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20892 USA. RP Kumar, S (reprint author), US FDA, CBER, DETTD, OBRR, 1401 Rockville Pike HFM-313, Rockville, MD 20852 USA. EM sanjai.kumar@fda.hhs.gov NR 64 TC 19 Z9 20 U1 0 U2 3 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD NOV 14 PY 2008 VL 283 IS 46 BP 31871 EP 31883 DI 10.1074/jbc.M800028200 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 370KJ UT WOS:000260760800070 PM 18693242 ER PT J AU Winemiller, MD Bae, SY AF Winemiller, Mark D. Bae, Sue Y. TI Liquid chromatography-time-of-flight mass spectrometry analysis of 1-(2-chloroethoxy)-2-[(2-chloroethyl)thio] ethane and related compounds: Separation of an eleven component mixture SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE Liquid chromatography; Mass spectrometry; Sulfur mustard; Hydrolysis ID CHEMICAL WARFARE AGENTS; ELECTROSPRAY-IONIZATION; DEGRADATION-PRODUCTS; 2-CHLOROETHYL SULFIDES; MUSTARD; IDENTIFICATION; HYDROLYSIS; SOIL; GAS AB A method of separation for an eleven component mixture comprised of 1-(2-chloroethoxy)-2-[(2-chloroethyl)thiol] ethane (4) and its derivatives has been developed using LC-time-of-flight-MS. All analytical figures of merit for compounds 1-11 have been determined. Compound 4 was examined in a substrate extraction study consisting of different sand and soil matrices, and a hydrolysis study of 4 on sand revealed an extremely complex degradation pathway which appeared to be concentration dependent. Substrate extraction and hydrolysis results where compared with sulfur mustard (HD). Published by Elsevier B.V. C1 [Winemiller, Mark D.; Bae, Sue Y.] US Army Edgewood Res, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Bae, SY (reprint author), US Army Edgewood Res, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM sue.bae@us.army.mil NR 17 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD NOV 14 PY 2008 VL 1210 IS 2 BP 185 EP 192 DI 10.1016/j.chroma.2008.09.050 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 374WL UT WOS:000261074300008 PM 18834989 ER PT J AU Brooks, MC Wood, AL Annable, MD Hatfield, K Cho, J Holbert, C Rao, RSC Enfield, CG Lynch, K Smith, RE AF Brooks, Michael C. Wood, A. Lynn Annable, Michael D. Hatfield, Kirk Cho, Jaehyun Holbert, Charles Rao, R. Suresh C. Enfield, Carl G. Lynch, Kira Smith, Richard E. TI Changes in contaminant mass discharge from DNAPL source mass depletion: Evaluation at two field sites SO JOURNAL OF CONTAMINANT HYDROLOGY LA English DT Article DE DNAPL; Source-zone remediation; Remediation performance metrics; Contaminant flux; Flux reduction; Passive flux meters; Integral pumping test ID AQUIFER REMEDIATION SYSTEMS; SOURCE STRENGTH FUNCTIONS; NONAQUEOUS PHASE LIQUIDS; UNIFORM-FLOW FIELDS; SOURCE ZONES; GROUNDWATER CONTAMINATION; CONCENTRATION RESPONSE; SCALE EVALUATION; POROUS-MEDIA; FLUX AB Changes in contaminant fluxes resulting from aggressive remediation of dense nonaqueous phase liquid (DNAPL) source zone were investigated at two sites, one at Hill Air Force Base (AFB). Utah, and the other at Ft. Lewis Military Reservation, Washington. Passive Flux Meters (PFM) and a variation of the Integral Pumping Test (IPT) were used to measure fluxes in ten wells installed along a transect down-gradient of the trichloroethylene (TCE) source zone, and perpendicular to the mean groundwater flow direction. At both sites, groundwater and contaminant fluxes were measured before and after the source-zone treatment. The measured contaminant fluxes (J; ML(-2)T(-1)) were integrated across the well transect to estimate contaminant mass discharge (M(D); MT(-1)) from the source zone. Estimated MD before source treatment, based on both PFM and IPT methods, were similar to 76 g/day for TCE at the Hill AFB site; and similar to 640 g/day for TCE, and similar to 206 g/day for cis-dichloroethylene (DCE) at the R. Lewis site. TCE flux measurements made 1 year after source treatment at the Hill AFB site decreased to similar to 5 g/day. On the other hand, increased fluxes of DCE, a degradation byproduct of TCE, in tests subsequent to remediation at the Hill AFB site suggest enhanced microbial degradation after surfactant flooding. At the Ft. Lewis site, TCE mass discharge rates subsequent to remediation decreased to similar to 3 g/day for TCE and similar to 3 g/day for DCE similar to 1.8 years after remediation. At both field sites, PFM and IPT approaches provided comparable results for contaminant mass discharge rates, and show significant reductions (> 90%) in TCE mass discharge as a result of DNAPL mass depletion from the source zone. Published by Elsevier B.V. C1 [Brooks, Michael C.; Wood, A. Lynn] US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA. [Annable, Michael D.; Hatfield, Kirk; Cho, Jaehyun] Univ Florida, Interdisciplinary Program Hydrol Sci, Gainesville, FL 32611 USA. [Holbert, Charles] CH2M Hill Inc, Salt Lake City, UT 84111 USA. [Rao, R. Suresh C.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA. [Enfield, Carl G.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Lynch, Kira] US EPA, Seattle, WA 98101 USA. [Smith, Richard E.] USA, Corps Engineers, Seattle, WA 98124 USA. RP Brooks, MC (reprint author), US EPA, Natl Risk Management Res Lab, Ada, OK 74820 USA. EM Brooks.Michael@epamail.epa.gov FU Strategic Environmental Research and Development Program (SERDP) FX The work upon which this paper is based was supported by the U.S. Environmental Protection Agency through its Office of Research and Development with funding provided by the Strategic Environmental Research and Development Program (SERDP), a collaborative effort involving the U.S. Environmental Protection Agency (EPA), the U.S. Department of Energy (DOE), and the U.S. Department of Defense (DoD). This paper has not been subjected to Agency review and, therefore, does not necessarily reflect the views of the Agency and no official endorsement should be inferred. The authors are grateful to Irene C. Poyer, Purdue University, for the analysis of groundwater samples collected during the IPTs; to Dr. Jimi Lee, now at the University of California-Riverside, for providing an estimate of the stainless steel well screen hydraulic conductivity; and to Jefferey Powers, US Army Corps of Engineers, for assistance with data collected by US Army Corps of Engineers. Review comments from Dr. Eva Davis, Kerr Research Center (EPA) and two anonymous reviewers are greatly appreciated. NR 56 TC 30 Z9 30 U1 4 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-7722 J9 J CONTAM HYDROL JI J. Contam. Hydrol. PD NOV 14 PY 2008 VL 102 IS 1-2 BP 140 EP 153 DI 10.1016/j.jconhyd.2008.05.008 PG 14 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA 381IK UT WOS:000261529100012 PM 18632182 ER PT J AU Abbott, KC Bohen, EM Hurst, FP AF Abbott, Kevin C. Bohen, Erin M. Hurst, Frank P. TI Oral Sodium Phosphate Drug Products and Renal Function SO ARCHIVES OF INTERNAL MEDICINE LA English DT Letter ID KIDNEY INJURY; RISK C1 [Abbott, Kevin C.] Walter Reed Army Med Ctr, Dialysis & Nephrol Serv, Washington, DC 20307 USA. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Dialysis & Nephrol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM kevin.abbott@amedd.army.mil NR 5 TC 0 Z9 0 U1 0 U2 3 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD NOV 10 PY 2008 VL 168 IS 20 BP 2285 EP 2285 DI 10.1001/archinte.168.20.2285-a PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 370XS UT WOS:000260797000017 PM 19001210 ER PT J AU Price, JA Rogers, JV McDougal, JN Shaw, MQ Reid, FM Kiser, RC Graham, JS AF Price, Jennifer A. Rogers, James V. McDougal, James N. Shaw, Morgan Q. Reid, Frances M. Kiser, Robyn C. Graham, John S. TI Gene expression analysis of bromine-induced burns in porcine skin SO TOXICOLOGY LETTERS LA English DT Article DE Bromine; Skin; Porcine; Microarray ID TOLL-LIKE RECEPTORS; GROWTH-FACTOR; CHEMOKINE RECEPTORS; CHEMICAL BURNS; SULFUR MUSTARD; PLASMINOGEN-ACTIVATOR; MICROARRAY ANALYSIS; DIABETIC-RATS; HIV-INFECTION; IMMUNE CELLS AB Bromine is an industrial chemical that is irritating to the skin and causes Cutaneous burns. An important factor in selecting or developing an effective treatment is to understand the underlying molecular mechanisms of tissue damage and wound healing. This study used a weanling swine burn mode) and microarray analysis to evaluate the effect of exposure length and sampling times on the transcriptional changes in response to cutaneous bromine injury. Ventral abdominal sites (N= 4/treatment group) were exposed to 600 mu L undiluted bromine for 45 s or 8 min. At 24 h and 7 d post-exposure, total RNA front skin samples was isolated, processed, and hybridized to Affymetrix GeneChip (R) Porcine Genome Arrays. Expression analysis revealed that bromine exposure duration appeared to have less effect on the transcript changes than the sampling time. The percent transcripts changed at 24 h were similar (30%) whether having a 45 s or 8 min bromine exposure; percent transcripts changed at 7 d were also similar (62%) regardless of exposure length. However, only 13-14% of the transcripts were similar when comparing samples analyzed at 24 h and 7 d. Ingenuity Pathways Analysis (IPA) revealed six common biological functions among the top 10 functions of each experimental group, while canonical pathway analysis revealed I I genes that were commonly shared among 24 significantly altered signaling pathways. Additionally, there were 11 signaling pathways in which there were no commonly shared transcripts. The present study is an initial assessment of the transcriptional responses to cutaneous bromine exposure identifying molecular networks and genes that could serve as targets for developing therapeutics for bromine-induced skin injury. (C) 2008 Elsevier Ireland Ltd. All rights reserved. C1 [Price, Jennifer A.; Rogers, James V.; Shaw, Morgan Q.; Reid, Frances M.; Kiser, Robyn C.] Battelle Mem Inst, Biomed Res Ctr, Columbus, OH 43201 USA. [McDougal, James N.] Wright State Univ, Dept Pharmacol & Toxicol, Dayton, OH 45435 USA. [Graham, John S.] USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Rogers, JV (reprint author), Battelle Mem Inst, Biomed Res Ctr, 505 King Ave JM-7, Columbus, OH 43201 USA. EM rogersjv@battelle.org FU DTRA/CBMS/MRMC [W81XWH-05-D-0001] FX This work was Supported by DTRA/CBMS/MRMC Contract W81XWH-05-D-0001, Task Order 0010. The authors thank Erin McGuinness for her excellent technical assistance. NR 73 TC 8 Z9 8 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD NOV 10 PY 2008 VL 182 IS 1-3 BP 69 EP 78 DI 10.1016/j.toxlet.2008.08.007 PG 10 WC Toxicology SC Toxicology GA 377XN UT WOS:000261285800012 PM 18790026 ER PT J AU Patch, JR Han, ZY McCarthy, SE Yan, LY Wang, LF Harty, RN Broder, CC AF Patch, Jared R. Han, Ziying McCarthy, Sarah E. Yan, Lianying Wang, Lin-Fa Harty, Ronald N. Broder, Christopher C. TI The YPLGVG sequence of the Nipah virus matrix protein is required for budding SO VIROLOGY JOURNAL LA English DT Article ID INFECTIOUS-ANEMIA VIRUS; UBIQUITIN-PROTEASOME SYSTEM; VESICULAR STOMATITIS-VIRUS; LATE ASSEMBLY DOMAIN; HOST PROTEINS; C-PROTEIN; BINDING PARTNER; FLYING-FOXES; VP40 PROTEIN; PARTICLES AB Background: Nipah virus (NiV) is a recently emerged paramyxovirus capable of causing fatal disease in a broad range of mammalian hosts, including humans. Together with Hendra virus (HeV), they comprise the genus Henipavirus in the family Paramyxoviridae. Recombinant expression systems have played a crucial role in studying the cell biology of these Biosafety Level-4 restricted viruses. Henipavirus assembly and budding occurs at the plasma membrane, although the details of this process remain poorly understood. Multivesicular body (MVB) proteins have been found to play a role in the budding of several enveloped viruses, including some paramyxoviruses, and the recruitment of MVB proteins by viral proteins possessing late budding domains (L-domains) has become an important concept in the viral budding process. Previously we developed a system for producing NiV virus-like particles (VLPs) and demonstrated that the matrix (M) protein possessed an intrinsic budding ability and played a major role in assembly. Here, we have used this system to further explore the budding process by analyzing elements within the M protein that are critical for particle release. Results: Using rationally targeted site-directed mutagenesis we show that a NiV M sequence YPLGVG is required for M budding and that mutation or deletion of the sequence abrogates budding ability. Replacement of the native and overlapping Ebola VP40 L-domains with the NiV sequence failed to rescue VP40 budding; however, it did induce the cellular morphology of extensive filamentous projection consistent with wild-type VP40-expressing cells. Cells expressing wild-type NiV M also displayed this morphology, which was dependent on the YPLGVG sequence, and deletion of the sequence also resulted in nuclear localization of M. Dominant-negative VPS4 proteins had no effect on NiV M budding, suggesting that unlike other viruses such as Ebola, NiV M accomplishes budding independent of MVB cellular proteins. Conclusion: These data indicate that the YPLGVG motif within the NiV M protein plays an important role in M budding; however, involvement of any specific components of the cellular MVB sorting pathway in henipavirus budding remains to be demonstrated. Further investigation of henipavirus assembly and budding may yet reveal a novel mechanism(s) of viral assembly and release that could be applicable to other enveloped viruses or have therapeutic implications. C1 [Patch, Jared R.; Yan, Lianying; Broder, Christopher C.] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA. [Han, Ziying; McCarthy, Sarah E.; Harty, Ronald N.] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA. [Wang, Lin-Fa] CSIRO Livestock Ind, Australian Anim Hlth Lab, Geelong, Vic 3220, Australia. [Patch, Jared R.] ARS, USDA, Plum Isl Anim Dis Ctr, Greenport, NY 11944 USA. [Han, Ziying] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. [McCarthy, Sarah E.] USA, Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Broder, CC (reprint author), Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA. EM Jared.Patch@ARS.USDA.GOV; Ziying.Han@fccc.edu; Sarah.E.Mccarthy@us.army.mil; lyan@usuhs.mil; Linfa.Wang@csiro.au; rharty@vet.upenn.edu; cbroder@usuhs.mil FU NIH [AI054715] FX This work was supported by NIH grant AI054715 to C.C.B. NR 57 TC 37 Z9 40 U1 1 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD NOV 10 PY 2008 VL 5 AR 137 DI 10.1186/1743-422X-5-137 PG 12 WC Virology SC Virology GA 395MN UT WOS:000262528300001 PM 19000317 ER PT J AU Stebulis, JA Johnson, DR Rossetti, RG Burstein, SH Zurier, RB AF Stebulis, Judith A. Johnson, David R. Rossetti, Ronald G. Burstein, Sumner H. Zurier, Robert B. TI Ajulemic acid, a synthetic cannabinoid acid, induces an antiinflammatory profile of eicosanoids in human synovial cells SO LIFE SCIENCES LA English DT Article DE Inflammation; Synovial cells; Prostaglandins; Cannabinoids; Cyclooxygenase 2 ID ACTIVATED RECEPTOR-GAMMA; NITRIC-OXIDE SYNTHASE; PROSTAGLANDIN E-2 SYNTHASE-1; ARTHRITIS-LIKE DISEASE; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); RHEUMATOID-ARTHRITIS; PPAR-GAMMA; CYCLOPENTENONE PROSTAGLANDINS; JOINT DESTRUCTION; GENE-EXPRESSION AB Aims: To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS). Main methods: FLS isolated from tissue obtained at joint replacement surgery or cultured from synovial fluid were treated for 60 min with AjA (10-30 mu M), then stimulated with tumor necrosis factor alpha (TNF alpha). COX2 mRNA was measured by hybridization/colorimetric assay of whole cell lysates collected 4 h after Stimulation. To determine FLS were incubated with C-14-arachidonic acid for 20 h then treated with AjA (8-effects on arachidonic acid release, 32 mu M). Arachidonic acid release was measured by scintillation counting. Prostaglandins (PC) were measured by enzyme linked immunosorbent assay (ELISA) in cell supernatants collected 4 and 24 h after stimulation. Key findings: AjA increased the steady state levels of COX2 mRNA in and arachidonic acid release from FLS. Treatment of FLS with AjA increased 15-deoxy-delta(12,14)-PGJ(2) (15d-PGJ(2)) production in a concentration dependent manner, but did not affect PGE(2) production significantly. Significance: The capacity of AjA to increase selectively and markedly 15d-PGJ2, all eicosanoid which facilitates resolution of inflammation, suggests that AjA may have value as a therapeutic agent for the treatment of rheumatoid arthritis (RA) and other diseases characterized by acute and chronic inflammation. (C) 2008 Elsevier Inc. All rights reserved. C1 [Stebulis, Judith A.] UMass Mem Med Ctr, Div Rheumatol, Worcester, MA 01605 USA. [Rossetti, Ronald G.; Burstein, Sumner H.; Zurier, Robert B.] Univ Massachusetts, Sch Med, Worcester, MA 01655 USA. [Johnson, David R.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Stebulis, JA (reprint author), UMass Mem Med Ctr, Div Rheumatol, 119 Belmont St, Worcester, MA 01605 USA. EM judith.stebulis@umassmed.edu FU NIH [T32 AR07572]; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) US; National Center for Complementary and Alternative Medicine (NCCAM) [R01 AT000309]; National Institute on Drug Abuse (NIDA) [R01 DA13691]; NIAID [AI056362] FX We gratefully acknowledge Ann Skulas and Francisco J. Atez for their excellent technical assistance with FLS culture maintenance. This study was supported by NIH grants T32 AR07572 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) US, Trainee), R01 AT000309 from the National Center for Complementary and Alternative Medicine (NCCAM), R01 DA13691 from the National Institute on Drug Abuse (NIDA), and AI056362 (NIAID). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the National Institutes of Health. NR 52 TC 14 Z9 15 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0024-3205 J9 LIFE SCI JI Life Sci. PD NOV 7 PY 2008 VL 83 IS 19-20 BP 666 EP 670 DI 10.1016/j.lfs.2008.09.004 PG 5 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 373EE UT WOS:000260953000006 PM 18840450 ER PT J AU Fan, SA Wu, F Martiniuk, F Hale, ML Ellington, AD Tchou-Wong, KM AF Fan, Shaoan Wu, Feng Martiniuk, Frank Hale, Martha L. Ellington, Andrew D. Tchou-Wong, Kam-Meng TI Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Ricin inhibitor; RNA aptamer; Luciferase assay ID RIBOSOME-INACTIVATING PROTEINS; IN-VITRO; TOXINS; MODEL; INHIBITION; ANTIBODIES; MECHANISM; ASSAY AB AIM: To investigate the therapeutic potential of an RNA ligand (aptamer) specific for the catalytic ricin A-chain (RTA), the protective effects of a 31-nucleotide RNA aptamer (31RA), which formed a high affinity complex with RTA, against ricin-induced toxicity in cell-based luciferase translation and cell cytotoxicity assays were evaluated. METHODS: To test the therapeutic potential of anti-RTA aptamers in Chinese hamster ovary (CHO) AA8 cells stably transfected with a tetracycline regulatable promoter, ricin ribotoxicity was measured using luciferase and ricin-induced cytotoxicity was ascertained by MTS cell proliferation assay with tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H- tetrazolium]. RESULTS: Inhibition of protein synthesis by ricin in CHO AA8 cells resulted in diminished luciferase activity and treatment with polyclonal antibody against degly-cosylated RTA (dgA) neutralized the inhibitory effects of ricin on luciferase activity and protected against ricin-induced cytotoxicity as measured by MTS assay. The 31RA anti-RTA aptamer inhibited the translation of luciferase mRNA in cell-free reticulocyte translation assay. 31RA aptamer also partially neutralized the inhibitory effects of ricin on luciferase activity and partially protected against ricin-induced cytotoxicity in CHO AA8 cells. CONCLUSION: We have shown that anti-RTA RNA aptamer can protect against ricin ribotoxicity in cell-based luciferase and cell cytotoxicity assays. Hence, RNA aptamer that inhibits RTA enzymatic activity represents a novel class of nucleic acid inhibitor that has the potential to be developed as a therapeutic agent for the treatment of ricin intoxication. (C) 2008 The WJG Press. All rights reserved. C1 [Fan, Shaoan; Wu, Feng; Tchou-Wong, Kam-Meng] NYU, Sch Med, Dept Environm Med, Tuxedo Pk, NY 10987 USA. [Martiniuk, Frank] NYU, Sch Med, Dept Med, New York, NY 10016 USA. [Hale, Martha L.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. [Ellington, Andrew D.] Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78712 USA. RP Tchou-Wong, KM (reprint author), NYU, Sch Med, Dept Environm Med, 57 Old Forge Rd, Tuxedo Pk, NY 10987 USA. EM tchouk02@nyumc.org FU National Institutes of Health (Tchou-Wong) [ES-000260, AI-059476] FX Grant from the National Institutes of Health (Tchou-Wong), No. ES-000260 and No. AI-059476 NR 20 TC 7 Z9 9 U1 1 U2 12 PU W J G PRESS PI BEIJING PA APT 1066, YISHOU GARDEN, NO 58, NORTH LANGXINZHUANG RD, PO BOX 2345, BEIJING 100023, PEOPLES R CHINA SN 1007-9327 J9 WORLD J GASTROENTERO JI World J. Gastroenterol. PD NOV 7 PY 2008 VL 14 IS 41 BP 6360 EP 6365 DI 10.3748/wjg.14.6360 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 374PX UT WOS:000261057300016 PM 19009652 ER PT J AU Alvarez-Aviles, L Simpson, WR Douglas, TA Sturm, M Perovich, D Domine, F AF Alvarez-Aviles, Laura Simpson, William R. Douglas, Thomas A. Sturm, Matthew Perovich, Donald Domine, Florent TI Frost flower chemical composition during growth and its implications for aerosol production and bromine activation SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID LAYER OZONE DEPLETION; SEA-SALT AEROSOL; POLAR SUNRISE; ICE; SNOW; SURFACE; REGIONS; TEMPERATURE AB Frost flowers have been proposed to be the major source of sea-salt aerosol to the atmosphere during polar winter and a source of reactive bromine during polar springtime. However little is known about their bulk chemical composition or microstructure, two important factors that may affect their ability to produce aerosols and provide chemically reactive surfaces for exchange with the atmosphere. Therefore, we chemically analyzed 28 samples of frost flowers and parts of frost flowers collected from sea ice off of northern Alaska. Our results support the proposed mechanism for frost flower growth that suggests water vapor deposition forms an ice skeleton that wicks brine present on newly grown sea ice. We measured a high variability in sulfate enrichment factors (with respect to chloride) in frost flowers and seawater from the vicinity of freezing sea ice. The variability in sulfate indicates that mirabilite precipitation (Na2SO4 center dot 10 H2O) occurs during frost flower growth. Brine wicked up by frost flowers is typically sulfate depleted, in agreement with the theory that frost flowers are related to sulfate-depleted aerosol observed in Antarctica. The bromide enrichment factors we measured in frost flowers are within error of seawater composition, constraining the direct reactive losses of bromide from frost flowers. We combined the chemical composition measurements with temperature observations to create a conceptual model of possible scenarios for frost flower microstructure development. C1 [Alvarez-Aviles, Laura; Simpson, William R.] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. [Alvarez-Aviles, Laura; Simpson, William R.] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [Domine, Florent] CNRS, Lab Glaciol & Geophys Environm, F-38402 St Martin Dheres, France. [Domine, Florent] Univ Grenoble 1, F-38402 St Martin Dheres, France. [Douglas, Thomas A.; Sturm, Matthew] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Perovich, Donald] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Alvarez-Aviles, L (reprint author), Univ Alaska Fairbanks, Inst Geophys, 900 Yukon Dr,Room 186, Fairbanks, AK 99775 USA. EM ffwrs@uaf.edu RI Domine, Florent/E-8699-2011; Simpson, William/I-2859-2014 OI Simpson, William/0000-0002-8596-7290 NR 39 TC 33 Z9 34 U1 0 U2 13 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD NOV 5 PY 2008 VL 113 IS D21 AR D21304 DI 10.1029/2008JD010277 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 370UL UT WOS:000260788500010 ER PT J AU Yu, L Putnak, JR Pletnev, AG Markoff, L AF Yu, Li Putnak, J. Robert Pletnev, Alexander G. Markoff, Lewis TI Attenuated West Nile viruses bearing 3 ' SL and envelope gene substitution mutations SO VACCINE LA English DT Article DE Live West Nile vaccine; Flavivirus 3 ' SL mutation; Attenuation of neurovirulence ID JAPANESE ENCEPHALITIS-VIRUS; CD8(+) T-CELLS; LETHAL CHALLENGE; MOLECULAR-BASIS; UNITED-STATES; NY99 STRAIN; GENOMIC RNA; VACCINE; FLAVIVIRUS; NEUROVIRULENCE AB Four viable West Nile (WN) 3'SL-mutant Viruses were evaluated for neuroinvasiveness and neurovirulence in mice. All mutants were highly attenuated for neuroinvasiveness. However, only one of these four (WNmutE virus) was significantly attenuated for neurovirulence. To attenuate WNmutE virus further, we introduced five substitution mutations into the envelope (env) gene segment in wild-type (wt) WN and WNmutE genomes, based on differences in the env gene Sequence between the live Japanese encephalitis vaccine (SA14-14-2) and its virulent parent. The env gene mutations had an attenuating effect in the context of the wt WNV genome but only a Marginal enhancing effect on the attenuation of WNmutE virus. Published by Elsevier Ltd. C1 [Yu, Li; Markoff, Lewis] US FDA, Div Viral Prod, Lab Vector Borne Virus Dis, Bethesda, MD 20892 USA. [Putnak, J. Robert] Walter Reed Army Inst Res, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. [Pletnev, Alexander G.] NIAID, Infect Dis Lab, NIH, Bethesda, MD 20892 USA. RP Yu, L (reprint author), Bg 29A,Room 1B18,NIH Campus,8800 Rockville Pike, Bethesda, MD 20892 USA. EM Li.Yu@fda.hhs.gov FU National Vaccine Program FX The authors thank Dr. V. Yamshchikov for the gift of the West Nile Virus strain B956 infectious DNA. This work was partially supported by a grant from the National Vaccine Program. NR 36 TC 19 Z9 20 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 5 PY 2008 VL 26 IS 47 BP 5981 EP 5988 DI 10.1016/j.vaccine.2008.08.064 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 384MZ UT WOS:000261750200014 PM 18805457 ER PT J AU Li, QG Xie, LS Zhang, J Weina, PJ AF Li, Qigui Xie, Lisa Zhang, Jing Weina, Peter J. TI The distribution pattern of intravenous [C-14] artesunate in rat tissues by quantitative whole-body autoradiography and tissue dissection techniques SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS LA English DT Article DE [C-14] Artesunate; Dihydroartemisinin; QWBA; LSC; Tissue distribution; Pharmacokinetics; Rats ID ENTEROHEPATIC CIRCULATION; BILIARY-EXCRETION; RADIOLUMINOGRAPHY; PHARMACOKINETICS; METABOLISM; ARTELINATE; ANIMALS AB Quantitative whole-body autoradiography (QWBA) and liquid scintillation counting (LSC) have been conducted to determine the metabolic profiles and tissue distribution of [C-14] labeled artesunate (AS) injection in rats. The QWBA technique showed more accurate results in the quantification of radioactivity in 40 organs and tissues, compared to 19 organs with the LSC technique. The benefit of QWBA was especially apparent on measurements of bile, bone marrow, and gland organs; however, the LSC method produced more relevant findings than QWBA. Particularly, the LSC method allowed access to the following distribution patterns that were unavailable via QWBA performance: such as pharmacokinetic evaluation of radiolabeled AS in blood and plasma, tissue/plasma partition coefficients, conversion pathway of AS to dihydroartemisinin (DHA, an active and major metabolite of AS), unchanged AS and DHA in plasma, mass balance assessment, urinary and faecal eliminations, drug pathway with conjugation, [14C] AS binding with RBC and plasma protein, and metabolites identification. Even though the each method has its own advantages, common profiles were obtained from the two processes as shown in the results of the biliary metabolism, long-lasting metabolites, tissue distribution profiles, and multiple concentration peaks, which indicate a [C-14] AS enterohepatic circulation. (c) 2008 Elsevier B.V. All rights reserved. C1 [Li, Qigui; Xie, Lisa; Zhang, Jing; Weina, Peter J.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Dept Pharmacol, Silver Spring, MD 20307 USA. RP Li, QG (reprint author), Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Div Expt Therapeut, Dept Pharmacol, 503 Robert Grant Ave, Silver Spring, MD 20307 USA. EM qigui.li@amedd.army.mil RI Weina, Peter/A-2120-2011 FU United States Army Research and Materiel Command FX This study was supported by the United States Army Research and Materiel Command. The opinions or assertions contained herein are the private views of the author and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 33 TC 6 Z9 7 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0731-7085 J9 J PHARMACEUT BIOMED JI J. Pharm. Biomed. Anal. PD NOV 4 PY 2008 VL 48 IS 3 BP 876 EP 884 DI 10.1016/j.jpba.2008.07.015 PG 9 WC Chemistry, Analytical; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA 362KL UT WOS:000260196500052 PM 18762400 ER PT J AU Parthasarathy, N Saksena, R Kovac, P DeShazer, D Peacock, SJ Wuthiekanun, V Heine, HS Friedlander, AM Cote, CK Welkos, SL Adamovicz, JJ Bavari, S Waag, DM AF Parthasarathy, N. Saksena, R. Kovac, P. DeShazer, D. Peacock, S. J. Wuthiekanun, V. Heine, H. S. Friedlander, A. M. Cote, C. K. Welkos, S. L. Adamovicz, J. J. Bavari, S. Waag, D. M. TI Application of carbohydrate microarray technology for the detection of Burkholderia pseudomallei, Bacillus anthracis and Francisella tularensis antibodies SO CARBOHYDRATE RESEARCH LA English DT Article DE Carbohydrate microarray; Burkholderia pseudomallei (melioidosis); Bacillus anthracis (anthrax); Francisella tularensis (tularemia); Serum antibodies ID GLYCAN ARRAYS; O-ANTIGEN; EXOSPORIUM; LIPOPOLYSACCHARIDE; MELIOIDOSIS; BCLA; OLIGOSACCHARIDE; GLYCOMICS; IDENTIFICATION; GLYCOPROTEIN AB We developed a microarray platform by immobilizing bacterial 'signature' carbohydrates onto epoxide modified glass slides. The carbohydrate microarray platform was probed with sera from non-melioidosis and melioidosis (Burkholderia pseudomallei) individuals. The platform was also probed with sera from rabbits vaccinated with Bacillus anthracis spores and Francisella tularensis bacteria. By employing this microarray platform, we were able to detect and differentiate B. pseudomallei, B. anthracis and F. tularensis antibodies in infected patients, and infected or vaccinated animals. These antibodies were absent in the sera of naive test subjects. The advantages of the carbohydrate microarray technology over the traditional indirect hemagglutination and microagglutination tests for the serodiagnosis of melioidosis and tularemia are discussed. Furthermore, this array is a multiplex carbohydrate microarray for the detection of all three biothreat bacterial infections including melioidosis, anthrax and tularemia with one, multivalent device. The implication is that this technology could be expanded to include a wide array of infectious and biothreat agents. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Parthasarathy, N.; DeShazer, D.; Heine, H. S.; Cote, C. K.; Welkos, S. L.; Adamovicz, J. J.; Bavari, S.; Waag, D. M.] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. [Saksena, R.; Kovac, P.] NIDDK, LBC, NIH, Bethesda, MD 20892 USA. [Peacock, S. J.; Wuthiekanun, V.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand. RP Parthasarathy, N (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. EM Narayanan.Parthasarathy@us.army.mil FU US Army Medical Research and Materiel Command [2.10018_06 _RD-B, 2.10019_07_RD-B, 5.10023_08_RD-B]; Welcome Trust Career Development fellowship in Clinical Tropical Medicine; Human Use Committee [FY 06-36, HP-06-36] FX The research described herein was sponsored by the US Army Medical Research and Materiel Command under projects 2.10018_06 _RD-B, 2.10019_07_RD-B and 5.10023_08_RD-B. The authors thank Sarah L. Norris for statistical analysis. The authors also thank Dr. Sharan VedBrat (KamTek Inc., Gaithersburg, MD) for carbohydrate printing. The support of staff at Sappasithiprasong Hospital, Ubon Ratchathani, and the Mahidol Oxford Tropical Medicine Research Unit, particularly Dr. Direk Limmathurotsakul and Dr. Allen Chang, is gratefully acknowledged. S.P. is funded by a Welcome Trust Career Development fellowship in Clinical Tropical Medicine. The use of human serum samples was approved by the Human Use Committee (FY 06-36, HP-06-36). Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. Opinions, interpretations, conclusions and recommendations are those of the authors and not endorsed by the US Army. NR 38 TC 19 Z9 19 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0008-6215 J9 CARBOHYD RES JI Carbohydr. Res. PD NOV 3 PY 2008 VL 343 IS 16 BP 2783 EP 2788 DI 10.1016/j.carres.2008.05.021 PG 6 WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Organic SC Biochemistry & Molecular Biology; Chemistry GA 370AU UT WOS:000260735900010 PM 18558401 ER PT J AU Peterson, JA AF Peterson, James A. TI Ten Common Mistakes Individuals Who Are Trying to Lose Weight Make SO ACSMS HEALTH & FITNESS JOURNAL LA English DT Editorial Material C1 [Peterson, James A.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1091-5397 J9 ACSMS HEALTH FIT J JI ACSMS Health Fit. J. PD NOV-DEC PY 2008 VL 12 IS 6 BP 52 EP 52 PG 1 WC Sport Sciences SC Sport Sciences GA 372FJ UT WOS:000260887200012 ER PT J AU Signore, C Aros, S Morrow, JD Troendle, J Conley, MR Flanigan, EY Cassorla, F Mills, JL AF Signore, Caroline Aros, Sofia Morrow, Jason D. Troendle, James Conley, Mary R. Flanigan, Elizabeth Y. Cassorla, Fernando Mills, James L. TI Markers of Oxidative Stress and Systemic Vasoconstriction in Pregnant Women Drinking >= 48 g of Alcohol per Day SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH LA English DT Article DE Alcohol; Pregnancy; Isoprostanes; Prostacyclin; Thromboxane; Fetal Alcohol Spectrum Disorders ID CHROMATOGRAPHY MASS-SPECTROMETRY; LIPID-PEROXIDATION; OXIDANT STRESS; IN-VIVO; 8-ISO-PROSTAGLANDIN F2-ALPHA; MATERNAL THROMBOXANE; BIOACTIVE PRODUCTS; BIOLOGICAL-FLUIDS; HUMAN PLACENTA; BLOOD-FLOW AB Background: The precise pathway by which alcohol causes the characteristic features of fetal alcohol spectrum disorders is unknown. Proposed mechanisms for fetal injury from maternal alcohol use include cellular damage from oxidative stress and impaired fetal oxygenation related to maternal systemic vasoconstriction. Our objective was to compare the levels of urinary markers of oxidative stress and systemic vasoconstriction between women consuming large amounts of alcohol during pregnancy and women who did not drink alcohol during pregnancy. Methods: Pregnant women consuming >= 48 g alcohol per day (n = 29) on average and pregnant women who abstained from alcohol use (n = 39) were identified using detailed interviews and home visits. Random maternal urine specimens were collected. Urinary levels of the oxidative stress marker, 8-isoprostane F2 alpha, and of the vasoactive prostaglandin metabolites, 2,3-dinor-6-keto-prostaglandin F1 alpha (a vasodilator) and 11-dehydro-thromboxane B2 (a vasoconstrictor), were measured using mass spectrometric methods. All analyte levels were corrected for urinary creatinine. Results: In crude analyses, there was no significant difference in 8-isoprostane F2 alpha between pregnant drinkers and nondrinkers (2.16 vs. 2.08 ng/mg creatinine, respectively, p = 0.87). There were no significant differences between the drinking and nondrinking groups in levels of 2,3-dinor-6-keto-prostaglandin F1 alpha (1.03 vs. 1.17 ng/mg creatinine, repectively, p = 0.50), 11-dehydro-thromboxane B2 (0.72 vs. 0.59 ng/mg creatinine, respectively, p = 0.21), or the ratio of vasodilatory metabolite to vasoconstrictive metabolite (1.73 vs. 2.72, respectively, p = 0.14). Adjusting for maternal age, marital status, smoking, and gestational age at sampling did not substantially alter the results. Conclusion: Our results show no difference in levels of urinary eicosanoid markers of oxidative stress and systemic vasoconstriction between pregnant women who drink heavily and pregnant women who abstain. These findings speak against a role for maternal oxidative stress or systemic vasoconstriction in the pathogenesis of alcohol damage to the fetus. C1 [Mills, James L.] NICHD, Epidemiol Branch, Div Epidemiol Stat & Prevent Res,NIH,US Dept Hlth, Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD 20892 USA. [Aros, Sofia] Univ Chile, San Borja Arriaran Clin Hosp, Sch Med, Dept Pediat, Santiago, Chile. [Morrow, Jason D.] Vanderbilt Univ, Sch Med, Div Clin Pharmacol, Dept Med, Nashville, TN 37212 USA. [Morrow, Jason D.] Vanderbilt Univ, Sch Med, Div Clin Pharmacol, Dept Pharmacol, Nashville, TN 37212 USA. [Troendle, James] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Biometry & Math Stat Branch, Div Epidemiol Stat & Prevent Res, NIH,US Dept Hlth & Human Serv, Bethesda, MD USA. [Flanigan, Elizabeth Y.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Washington, DC USA. [Flanigan, Elizabeth Y.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Cassorla, Fernando] Univ Chile, Inst Maternal & Child Res, Dept Pediat, Div Pediat Endocrinol, Santiago, Chile. RP Mills, JL (reprint author), NICHD, Epidemiol Branch, Div Epidemiol Stat & Prevent Res,NIH,US Dept Hlth, Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD 20892 USA. EM MillsJ@mail.nih.gov FU Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institutes of Health [GM15431, DK48831, ES13125] FX This research was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development and by National Institutes of Health grants GM15431, DK48831 and ES13125. NR 47 TC 8 Z9 9 U1 2 U2 6 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0145-6008 J9 ALCOHOL CLIN EXP RES JI Alcoholism (NY) PD NOV PY 2008 VL 32 IS 11 BP 1893 EP 1898 DI 10.1111/j.1530-0277.2008.00773.x PG 6 WC Substance Abuse SC Substance Abuse GA 362FK UT WOS:000260183400005 PM 18715278 ER PT J AU Hoge, CW AF Hoge, Charles W. TI RE: "PSYCHIATRIC DIAGNOSES IN HISTORIC AND CONTEMPORARY MILITARY COHORTS: COMBAT DEPLOYMENT AND THE HEALTHY WARRIOR EFFECT SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Letter ID POSTTRAUMATIC-STRESS-DISORDER; IRAQ; AFGHANISTAN; WAR C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM charles.hoge@us.army.mil NR 9 TC 10 Z9 10 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD NOV 1 PY 2008 VL 168 IS 9 BP 1095 EP U12 DI 10.1093/aje/kwn261 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 365BM UT WOS:000260380900021 PM 18775923 ER PT J AU Van Uitert, RL Summers, RM White, JM Deshpande, KK Choi, JR Pickhardt, PJ AF Van Uitert, Robert L. Summers, Ronald M. White, Jacob M. Deshpande, Keshav K. Choi, J. Richard Pickhardt, Perry J. TI Temporal and Multiinstitutional Quality Assessment of CT Colonography SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE colon; colonography; CT; quality; virtual colonoscopy ID COMPUTED TOMOGRAPHIC COLONOGRAPHY; OPTIMIZING COLONIC DISTENSION; COLORECTAL NEOPLASIA; VIRTUAL COLONOSCOPY; CARBON-DIOXIDE; RESIDUAL FLUID; INSUFFLATION; VALIDATION; EXPERIENCE AB OBJECTIVE. The purpose of this study was to investigate the variability of CT colonography (CTC) scan quality obtained within and between institutions by using previously validated automated quality assessment (QA) software that assesses colonic distention and surface area obscured by residual fluid. MATERIALS AND METHODS. The CTC scans of 120 patients were retrospectively selected, 30 from each of four institutions. The bowel preparation included oral contrast material for fecal and fluid tagging. Patients at one institution (institution 4) drank half the amount of oral contrast material compared with the patients at the other three institutions. Fifteen of the CTC scans were from the beginning of the protocol studied at each institution and 15 scans were from the same protocol acquired approximately 1 year later in the study. We used previously validated QA software to automatically measure the mean distention and residual fluid of each of five colonic segments (ascending, transverse, descending, sigmoid, and rectum). Adequate distention was defined as a colonic diameter of at least 2 cm. Residual fluid was determined by the percentage of colonic surface area covered by fluid. We compared how the quality varied across multiple institutions and over time within the same institution. RESULTS. No significant difference in the amount of colonic distention among the four institutions was found (p = 0.19). However, the distention in the prone position was significantly greater than the distention in the supine position (p < 0.001). Patients at institution 4 had about half the amount of residual colonic fluid compared with patients at the other three institutions (p < 0.01). The sigmoid and descending colons were the least distended segments, and the transverse and descending colons contained the most fluid on the prone and supine scans, respectively. More recently acquired studies had greater distention and less residual fluid, but the differences were not statistically significant (p = 0.30 and p = 0.96, respectively). CONCLUSION. Across institutions, a significant difference can exist in bowel preparation quality for CTC. This study reaffirms the need for standardized bowel preparation and quality monitoring of CTC examinations to reduce poor CTC performance. C1 [Van Uitert, Robert L.; Summers, Ronald M.; White, Jacob M.; Deshpande, Keshav K.] Natl Inst Hlth Clin Ctr, Bethesda, MD 20892 USA. [Choi, J. Richard] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Choi, J. Richard] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. [Pickhardt, Perry J.] Univ Wisconsin, Sch Med, Dept Radiol, Madison, WI USA. RP Summers, RM (reprint author), Natl Inst Hlth Clin Ctr, Bldg 10,Rm 1C368X MSC 1182, Bethesda, MD 20892 USA. EM rms@nih.gov FU National Institutes of Health Clinical Center FX This study was supported by the Intramural Research Program of the National Institutes of Health Clinical Center. NR 25 TC 6 Z9 6 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X EI 1546-3141 J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD NOV PY 2008 VL 191 IS 5 BP 1503 EP 1508 DI 10.2214/AJR.07.3591 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 363DQ UT WOS:000260246700034 PM 18941092 ER PT J AU Tyler, JA McDermott, D Levoyer, T AF Tyler, Joshua A. McDermott, Dustin Levoyer, Thomas TI Sterile Intra-Abdominal Fluid Collection Associated with Seprafilm Use SO AMERICAN SURGEON LA English DT Article ID ADHESIONS; SURGERY; COMPLICATION; PREVENTION; EFFICACY; BARRIER; SAFETY AB Postoperative abdominal adhesions are a significant cause of morbidity and expenditure of healthcare resources. As a result, numerous substances have been studied in an effort to reduce the incidence of adhesive disease. Seprafilm, a hyaluronate-based bioresorbable membrane, has been the subject of considerable research and has been found to be both safe and effective in reducing postoperative adhesions. We report three cases of the development of sterile abdominal fluid collection after the use of Seprafilm in colorectal surgery. C1 [Tyler, Joshua A.] Brooke Army Med Ctr, ATTN MCHE SDG, Dept Gen Surg, Ft Sam Houston, TX 78234 USA. RP Tyler, JA (reprint author), Brooke Army Med Ctr, ATTN MCHE SDG, Dept Gen Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Josh.Tyler@amedd.army.mil NR 17 TC 5 Z9 5 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD NOV PY 2008 VL 74 IS 11 BP 1107 EP 1110 PG 4 WC Surgery SC Surgery GA 373WX UT WOS:000261005300014 PM 19062671 ER PT J AU Haymore, BR Yoon, J Mikita, CP Klote, MM DeZee, KJ AF Haymore, Bret R. Yoon, Jiun Mikita, Cecilia P. Klote, Mary M. DeZee, Kent J. TI Risk of angioedema with angiotensin receptor blockers in patients with prior angioedema associated with angiotensin-converting enzyme inhibitors: a meta-analysis SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID ANTAGONISTS AB Background: Patients who have angioedema after taking angiotensin-converting enzyme inhibitors (ACE-Is) have been reported to develop angioedema when taking an angiotensin receptor blocker (ARB), but few studies quantify the risk. Objective: To perform a systematic review of the literature. Methods: A literature search was performed in MEDLINE, EMBASE, BIOSIS, and Current Contents, with no limitations from January 1990 to May 2007. Any article that described a cohort of patients who had angioedema after taking an ACE-I, were subsequently exposed to an ARB, and were followed for a least I month were included. The percentage of patients who had angioedema was abstracted from each article, and confidence intervals were calculated using the exact binomial method. The pooled percentage was calculated with the inverse variance method. Results: Two-hundred fifty-four unique articles were identified, and 3 articles met inclusion criteria, which described 71 patients with the outcome of interest. One was a randomized controlled trial and 2 were retrospective cohorts. These articles described both confirmed and possible cases of angioedema. The risk of angioedema was 9.4% (95% confidence interval, 1.6%-17%) for possible cases and 3.5% (95% confidence interval, 0.0%-9.2%) for confirmed cases. No fatal events were reported. No statistical heterogeneity was reported between trials (P >.3). Conclusions: Limited evidence suggests that for patients who develop angioedema when taking an ACE-I, the risk of development of any subsequent angioedema when taking an ARB is between 2% and 17%; for confirmed angioedema, the risk is 0% to 9.2%. This information will aid clinicians in counseling patients regarding therapy options after development of angioedema due to ACE-Is. C1 [Haymore, Bret R.; Yoon, Jiun; Mikita, Cecilia P.; Klote, Mary M.] Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. [DeZee, Kent J.] William Beaumont Army Med Ctr, Dept Internal Med, El Paso, TX 79920 USA. RP Haymore, BR (reprint author), 5213 Flanders Ave, Kensington, MD 20895 USA. EM bret.haymore@amedd.army.mil NR 14 TC 50 Z9 52 U1 0 U2 1 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD NOV PY 2008 VL 101 IS 5 BP 495 EP 499 PG 5 WC Allergy; Immunology SC Allergy; Immunology GA 369WY UT WOS:000260725800009 PM 19055203 ER PT J AU Asplund, CA Seehusen, DA Callahan, TL Olsen, C AF Asplund, Chad A. Seehusen, Dean A. Callahan, Terra L. Olsen, Cara TI Percentage Change in Antenatal Body Mass Index as a Predictor of Neonatal Macrosomia SO ANNALS OF FAMILY MEDICINE LA English DT Article DE Fetal macrosomia; body mass index; pregnancy ID ESTIMATED FETAL WEIGHT; MATERNAL CHARACTERISTICS; BIRTH-WEIGHT; FETUS; RISK; PREGNANCIES; MANAGEMENT; OUTCOMES AB PURPOSE We wanted to evaluate the predictive value of percentage change in antenatal maternal body mass index (BMI) as it relates to macrosomia, as well as to compare change in pregnancy BMI with existing weight gain guidelines. METHODS We analyzed data from 6 months of consecutive deliveries, focusing on first visit (first trimester) BMI, last visit (37 weeks or later) BMI, and fetal birth weight. Using regression and chi(2) analyses, we evaluated the relationship between change in BMI and macrosomia. RESULTS Of the 238 consecutive deliveries, we were able to analyze data from 186, of which 15.6% (n = 29) of the infants were macrosomic. Among macrosomic infants, 86.2% (25/29) of their mothers had a 25% or greater increase in BMI compared with 6.6% (10/157) of mothers of normal-weight infants (P <.001), for a relative risk 13.5% (95% confidence interval [0], 7.3%-25.1%). Percentage change in BMI of 25% or greater had a sensitivity of 86.2% (95% Cl, 68.3%-96.1%), a specificity of 93.6% (95% Cl, 88.6%-96.9%), a positive predictive value of 71.4% (95% Cl, 53.7%-85.4%), and a negative predictive value 97.4% (95% Cl, 93.4%-99.3%) for macrosomia. Logistic regression adjusted for maternal age, race, parity, and gravidity showed that those women whose BMI increased 25% or greater were more than 200 times more likely (odds ratio [OR] = 219.3; 95% Cl, 38.8-1,238.6; P <.001) to give birth to a macrosomic infant. Further adjusting for initial BMI strengthened the association (OR = 1,062.4; 95% Cl, 83.2-13,572.2; P < 001). Regardless of weight gain, when compared with Institute of Medicine weight gain recommendations, change in BMI or 25% or greater was associated with macrosomia (P <.001). CONCLUSION Independent of initial pregnancy BMI or absolute weight gain, an increase in maternal BMI of 25% or greater during pregnancy is highly predictive of macrosomia. Ann Fam Med 2008:6;550-554. DOI: 10.1370/afm.903. C1 [Asplund, Chad A.; Seehusen, Dean A.; Callahan, Terra L.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA. [Olsen, Cara] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Asplund, CA (reprint author), Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA. EM chad.asplund@osumc.edu NR 20 TC 14 Z9 14 U1 0 U2 1 PU ANNALS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, LEAWOOD, KS 66211-2672 USA SN 1544-1709 J9 ANN FAM MED JI Ann. Fam. Med. PD NOV-DEC PY 2008 VL 6 IS 6 BP 550 EP 554 DI 10.1370/afm.903 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 374GJ UT WOS:000261031500012 PM 19001308 ER PT J AU Shanti, RM Janjanin, S Li, WJ Nesti, LJ Mueller, MB Tzeng, MB Tuan, RS AF Shanti, Rabie M. Janjanin, Sasa Li, Wan-Ju Nesti, Leon J. Mueller, Michael B. Tzeng, Megan B. Tuan, Rocky S. TI In Vitro Adipose Tissue Engineering Using an Electrospun Nanofibrous Scaffold SO ANNALS OF PLASTIC SURGERY LA English DT Article DE adipose tissue engineering; electrospinning; nanofibers; mesechymal stem cells; tissue engineering ID MESENCHYMAL STEM-CELLS; COLLAGEN IMPLANT; AUGMENTATION; VIVO; PREADIPOCYTES; MATRIX; DIFFERENTIATION; TRANSPLANTATION; PROLIFERATION; LIPOSUCTION AB Electrospun 3-dimensional nanofibrous scaffolds share morphologic similarities to collagen fibrils, and promote favorable biologic responses of seeded cells. In this Study, we have fabricated a 3-dimensional nanofibrous scaffold made of poly L-lactic acid, and examined its ability to support and maintain the adipogenic differentiation of human bone marrow-derived mesenchymal stem cells in vitro. After a 21-day incubation, on red O staining of constructs treated with adipogenic supplements revealed positive adipose-like staining, compared with lack of staining in untreated cultures. Semi-quantitative RT-PCR analysis of human bone marrow-derived mesenchymal stern Cells Cultured in adipogenic medium revealed highly elevated levels of adipogenesis-associated genes (1797-fold for lipoprotein lipase, and 5.6-fold for peroxisome proliferator-activated receptor gamma). Immunofluorescence staining of cellular constructs in adipogenic culture media showed the presence of lipoprotein lipase vesicles, a characteristic feature of adipose tissue. These results suggest that the poly L-lactic acid-based nanofibrous scaffold is a promising candidate for adult stern cell-based engineering of adipose tissue. C1 [Shanti, Rabie M.; Janjanin, Sasa; Li, Wan-Ju; Mueller, Michael B.; Tzeng, Megan B.; Tuan, Rocky S.] NIAMSD, Dept Hlth & Human Serv, Cartilage Biol & Orthopaed Branch, NIH, Bethesda, MD 20892 USA. [Shanti, Rabie M.] NIH, Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20892 USA. [Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Tuan, RS (reprint author), NIAMSD, Dept Hlth & Human Serv, Cartilage Biol & Orthopaed Branch, NIH, Bldg 50,Room 1523,MSC 8022, Bethesda, MD 20892 USA. EM shanti.rabie@gmail.com FU Intramural Research Program of NIAMS [NIH Z01 AR 41131] FX The authors thank the Light Imaging Section of the Intramural Research National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Dr. James A. Cooper for aid in confocal laser scanning microscopy and scanning electron microscopy, respectively. This work is supported by the Intramural Research Program of NIAMS (NIH Z01 AR 41131). NR 43 TC 23 Z9 25 U1 0 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-7043 J9 ANN PLAS SURG JI Ann. Plast. Surg. PD NOV PY 2008 VL 61 IS 5 BP 566 EP 571 DI 10.1097/SAP.0b013e31816d9579 PG 6 WC Surgery SC Surgery GA 364VP UT WOS:000260363800022 PM 18948788 ER PT J AU Drusano, GL Okusanya, OO Okusanya, A Van Scoy, B Brown, DL Kulawy, R Soergel, F Heine, HS Louie, A AF Drusano, G. L. Okusanya, Olanrewaju O. Okusanya, Adedoyin Van Scoy, Brian Brown, D. L. Kulawy, Robert Soergel, Fritz Heine, Henry S. Louie, Arnold TI Is 60 Days of Ciprofloxacin Administration Necessary for Postexposure Prophylaxis for Bacillus anthracis? SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID NEW-YORK-CITY; ANTIBIOTIC-PROPHYLAXIS AB Sixty days of ciprofloxacin administration at 500 mg every 12 h is currently recommended for the prophylaxis of inhalational exposure to Bacillus anthracis. We examined Bacillus anthracis (Delta-Sterne strain) in our hollow-fiber infection model. We measured the ciprofloxacin concentrations achieved and the number of organisms present before heat shock ( total population) and after heat shock ( spore population). We fit a mathematical model to these data. Monte Carlo simulation with differing initial spore burdens (3, 5, and 6.9 log(10) CFU/ml) demonstrated that 35 days of this regimen would completely clear the spore burden in 95% of patients. Durations of 110 days did not achieve 99.9% eradication, irrespective of initial burden, because of between-patient variance in drug pharmacokinetics. Given the absence of person-to-person transmission for Bacillus anthracis, adverse drug effects with long-term ciprofloxacin administration, and the possibility of engendering resistance in bodily flora, shorter prophylaxis duration should be given consideration, along with careful monitoring of all exposed individuals. C1 [Drusano, G. L.; Okusanya, Adedoyin; Van Scoy, Brian; Brown, D. L.; Kulawy, Robert; Louie, Arnold] Ordway Res Inst, Lab Emerging Infect, Albany, NY 12208 USA. [Okusanya, Olanrewaju O.] Ordway Res Inst, Inst Clin Pharmacodynam, Albany, NY 12208 USA. [Soergel, Fritz] Inst Biomed & Pharmaceut Res, Nurnberg, Germany. [Heine, Henry S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Drusano, GL (reprint author), Ordway Res Inst, Lab Emerging Infect, 150 New Scotland Ave, Albany, NY 12208 USA. EM Gdrusano@ordwayresearch.org FU "Choosing Drug Doses for Biodefense Pathogens." [1 PO1 AI060908- 01A1] FX This study was funded by 1 PO1 AI060908- 01A1, "Choosing Drug Doses for Biodefense Pathogens."; All the authors state that they have no conflicts of interest. NR 13 TC 11 Z9 11 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD NOV PY 2008 VL 52 IS 11 BP 3973 EP 3979 DI 10.1128/AAC.00453-08 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 363ZI UT WOS:000260305600021 PM 18725437 ER PT J AU Brunye, TT Taylor, HA Rapp, DN AF Brunye, Tad T. Taylor, Holly A. Rapp, David N. TI Repetition and Dual Coding in Procedural Multimedia Presentations SO APPLIED COGNITIVE PSYCHOLOGY LA English DT Article ID COGNITIVE LOAD; ANNOTATED ILLUSTRATIONS; INSTRUCTIONAL-DESIGN; SEDUCTIVE DETAILS; WORKING-MEMORY; TEXT; PICTURES; ADULTS AB Students learned toy assembly sequences presented in Picture, text, or one of three multimedia formats, and completed order verification, recall, and object assembly tasks. Experiment I compared repetitious (i.e. dual format presentations each conveying similar information) with complementary (i.e. dual format presentations each conveying different information) Multimedia presentations. Repetitious, presentations appear to provide learning benefits as a function of their inherent redundancy: complementary presentations provide benefits as a result of users actively integrating Picture and text elements into a cohesive mental model. Experiment 2 compared repetitious With interleaved (i.e. assembly steps presented in alternating picture-text formats) multimedia presentations. Again. multimedia presentations led to overall learning advantages relative to single-format presentations. with an emphasis on both repetition and integrative working memory processes. Object assembly performance consistently demonstrated the utility of picture learning, with or without accompanying text. Results are considered relative to classic and contemporary learning theory. and inform educational design. Copyright (C) 2007 John Wiley & Son, Ltd. C1 [Brunye, Tad T.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.] USA, RDEC, Natick, MA USA. [Rapp, David N.] Northwestern Univ, Sch Educ & Social Policy, Evanston, IL 60208 USA. [Rapp, David N.] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tbruny01@tufts.edu NR 35 TC 9 Z9 9 U1 2 U2 6 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0888-4080 J9 APPL COGNITIVE PSYCH JI Appl. Cogn. Psychol. PD NOV PY 2008 VL 22 IS 7 BP 877 EP 895 DI 10.1002/acp.1396 PG 19 WC Psychology, Experimental SC Psychology GA 381FT UT WOS:000261521800002 ER PT J AU Seely, JF Holland, GE Hudson, LT Henins, A AF Seely, John F. Holland, Glenn E. Hudson, Lawrence T. Henins, Albert TI X-ray modulation transfer functions of photostimulable phosphor image plates and scanners SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT 1st North American Symposium, on Laser Induced Breakdown Spectroscopy CY OCT 08-10, 2007 CL New Orleans, LA SP Mississippi State Univ ID CRYSTAL SPECTROMETER; TRANSMISSION; SYSTEMS; LASER AB The modulation transfer functions of two types of photostimulable phosphor image plat were determined in the 10 keV to 50 keV x-ray energy range using a resolution test pattern with up to 10 line pairs per mm (LP/mm) and a wavelength dispersive x-ray spectrometer. Techniques were developed for correcting For the partial transmittance of the high energy x-rays through the lead bars of the resolution test pattern, and the modulation transfer function (MTF) was determined from the measured change in contrast with LP/mm values. The MTF was convolved with the slit function of the image plate scanner, and the resulting point spread functions (PSFs) were in good agreement with the observed shapes and widths of x-ray spectral lines and with the PSF derived from edge spread functions. The shapes and the full width at half-maximum (FWHM) values of the PSF curves of the Fuji Superior Resolution (SR) and Fuji Maximum Sensitivity (MS) image plate detectors, consisting of the image plate and the scanner, determined by the three methods gave consistent results: The SR PSF is Gaussian with 0.13 mm FWHM, and the MS PSF is Lorentzian with 0.19 mm FWHM. These techniques result in the accurate determination of the spatial resolution achievable using image plate and scanner combinations and enable the optimization of spatial resolution for x-ray spectroscopy and radiography (C) 2008 Optical Society of America C1 [Seely, John F.] USA, Res Lab, Div Space Sci, Washington, DC 20375 USA. [Holland, Glenn E.] SFA Inc, Crofton, MD 21114 USA. [Hudson, Lawrence T.; Henins, Albert] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. RP Seely, JF (reprint author), USA, Res Lab, Div Space Sci, Washington, DC 20375 USA. EM john.seely@nrl.navy.mil NR 14 TC 15 Z9 16 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2008 VL 47 IS 31 BP 5753 EP 5761 DI 10.1364/AO.47.005753 PG 9 WC Optics SC Optics GA 374AD UT WOS:000261013700027 PM 19122716 ER PT J AU Nguyen, DT Sheng, C Thomas, J Norwood, R Kimball, B Steeves, DM Peyghambarian, N AF Nguyen, Dan T. Sheng, Chuanxiang Thomas, Jayan Norwood, Robert Kimball, Brian Steeves, Diane M. Peyghambarian, Nasser TI Observation of nonlinear transmission enhancement in cavities filled with nonlinear organic materials SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT 1st North American Symposium, on Laser Induced Breakdown Spectroscopy CY OCT 08-10, 2007 CL New Orleans, LA SP Mississippi State Univ ID CARBON NANOTUBES; OPTICAL LIMITER; FABRY-PEROT; SEMICONDUCTORS; BISTABILITY; PULSES AB We show experimental and theoretical results for enhancement of nonlinear transmission (NT) in moderate finesse cavities filled with nonlinear organic materials (NLOM). Our design for enhancement of nonlinear transmission using micro NLOM cavities compared with reference samples of the same material show that single cavities can enhance the nonlinear response by a factor of 10 or greater under high-absorption conditions. Further enhancement can be achieved in multiple-cavity structures. Other advantages of the cavity structures for nonlinear transmission, such as a higher damage threshold and a broader NT band, are also discussed. Our initial experimental results show a threefold reduction in the nonlinear threshold fluence in a single cavity device compared directly to an identical sample without mirrors, in qualitative agreement With our calculations. (C) 2008 Optical Society of America C1 [Nguyen, Dan T.; Sheng, Chuanxiang; Thomas, Jayan; Norwood, Robert; Peyghambarian, Nasser] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Kimball, Brian; Steeves, Diane M.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Nguyen, DT (reprint author), Univ Arizona, Coll Opt Sci, 1630 E Univ Blvd, Tucson, AZ 85721 USA. EM dnguyen@optics.arizona.edu OI Nguyen, Dan/0000-0002-5244-8304 NR 25 TC 5 Z9 5 U1 0 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2008 VL 47 IS 31 BP 5777 EP 5783 DI 10.1364/AO.47.005777 PG 7 WC Optics SC Optics GA 374AD UT WOS:000261013700030 PM 19122719 ER PT J AU De Lucia, FC Gottfried, JL Munson, CA Miziolek, AW AF De Lucia, Frank C., Jr. Gottfried, Jennifer L. Munson, Chase A. Miziolek, Andrzej W. TI Multivariate analysis of standoff laser-induced breakdown spectroscopy spectra for classification of explosive-containing residues SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT 1st North American Symposium, on Laser Induced Breakdown Spectroscopy CY OCT 08-10, 2007 CL New Orleans, LA SP Mississippi State Univ ID DISCRIMINANT-ANALYSIS; STRATEGIES; SENSOR AB A technique being evaluated for standoff explosives detection is laser-induced breakdown spectroscopy (LIBS). LIBS is a real-time sensor technology that uses components that can be configured into a ruggedized standoff instrument. The U.S. Army Research Laboratory has been coupling standoff LIBS spectra with chemometrics for several years now in order to discriminate between explosives and nonexplosives. We have investigated the use of partial least squares discriminant analysis (PLS-DA) for explosives detection. We have extended our study of PLS-DA to more complex sample types, including binary mixtures, different types of explosives, and samples not included in the model. We demonstrate the importance of building the PLS-DA model by iteratively testing it against sample test sets. Independent test sets are used to test the robustness of the final model. (C) 2008 Optical Society of America C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.; Munson, Chase A.; Miziolek, Andrzej W.] USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. RP De Lucia, FC (reprint author), USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. EM fdelucia@arl.army.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012; Munson, Chase/H-1667-2012 NR 24 TC 72 Z9 73 U1 3 U2 21 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2008 VL 47 IS 31 BP G112 EP G121 DI 10.1364/AO.47.00G112 PG 10 WC Optics SC Optics GA 374AD UT WOS:000261013700016 PM 19122692 ER PT J AU McManus, CE McMillan, NJ Harmon, RS Whitmore, RC De Lucia, FC Miziolek, AW AF McManus, Catherine E. McMillan, Nancy J. Harmon, Russell S. Whitmore, Robert C. De Lucia, Frank C., Jr. Miziolek, Andrzej W. TI Use of laser induced breakdown spectroscopy in the determination of gem provenance: beryls SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT 1st North American Symposium, on Laser Induced Breakdown Spectroscopy CY OCT 08-10, 2007 CL New Orleans, LA SP Mississippi State Univ ID LA-ICP-MS; PEGMATITES; MAINE; AREA AB The provenance of gem stones has been of interest to geologists, gemologists, archeologists, and historians for centuries. Laser induced breakdown spectroscopy (LIBS) provides a minimally destructive tool for recording the rich chemical signatures of gem beryls (aquamarine, goshenite, heliodor, and morganite). Broadband LIBS spectra of 39 beryl (Be3Al2Si6O18) specimens from 11 pegmatite mines in New Hampshire, Connecticut, and Maine (USA) are used to assess the potential of using principal component analysis of LIBS spectra to determine specimen provenance. Using this technique, beryls from the three beryl-bearing zones in the Palermo #1 pegmatite (New Hampshire) can be recognized. However, the compositional variation within this single mine is comparable to that in beryls from all three states. Thus, a very large database with detailed location metadata will be required to routinely determine gem beryl provenance. (C) 2008 Optical Society of America C1 [McManus, Catherine E.; McMillan, Nancy J.] New Mexico State Univ, Dept Geol Sci, Las Cruces, NM 88003 USA. [Harmon, Russell S.] USA, Res Off, Div Environm Sci, Res Triangle Pk, NC 27709 USA. [Whitmore, Robert C.] Palermo Min Inc, Weare, NH 03281 USA. [De Lucia, Frank C., Jr.; Miziolek, Andrzej W.] USA, Res Lab, Weap & Mat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP McManus, CE (reprint author), New Mexico State Univ, Dept Geol Sci, MSC 3AB, Las Cruces, NM 88003 USA. EM katedowe@aol.com RI De Lucia, Frank/D-5630-2012 NR 16 TC 19 Z9 19 U1 1 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2008 VL 47 IS 31 BP G72 EP G79 DI 10.1364/AO.47.000G72 PG 8 WC Optics SC Optics GA 374AD UT WOS:000261013700011 PM 19122706 ER PT J AU Munson, CA Gottfried, JL Snyder, EG De Lucia, FC Gullett, B Miziolek, AW AF Munson, Chase A. Gottfried, Jennifer L. Snyder, Emily Gibb De Lucia, Frank C., Jr. Gullett, Brian Miziolek, Andrzej W. TI Detection of indoor biological hazards using the man-portable laser induced breakdown spectrometer SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT 1st North American Symposium, on Laser Induced Breakdown Spectroscopy CY OCT 08-10, 2007 CL New Orleans, LA SP Mississippi State Univ ID SPECTROSCOPY; DISCRIMINATION; CLASSIFICATION; STRATEGIES; SURFACES; SENSOR; SPORES; LIBS AB The performance of a man-portable laser induced breakdown spectrometer was evaluated for the detection of biological powders on indoor office surfaces and wipe materials. Identification of pure unknown powders was performed by comparing against a library of spectra containing biological agent surrogates and confusant materials, such as dusts, diesel soot, natural and artificial sweeteners, and drink powders, using linear correlation analysis. Simple models constructed using a second technique, partial least squares discriminant analysis, successfully identified Bacillus subtilis (BG) spores on wipe materials and office surfaces. Furthermore, these models were able to identify BG on materials not used in the training of the model. (C) 2008 Optical Society of America C1 [Munson, Chase A.; Gottfried, Jennifer L.; De Lucia, Frank C., Jr.; Miziolek, Andrzej W.] USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. [Snyder, Emily Gibb] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [Gullett, Brian] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. RP Munson, CA (reprint author), USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. EM cmunson@arl.army.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012; Munson, Chase/H-1667-2012 NR 23 TC 23 Z9 23 U1 3 U2 10 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2008 VL 47 IS 31 BP G48 EP G57 DI 10.1364/AO.47.000G48 PG 10 WC Optics SC Optics GA 374AD UT WOS:000261013700008 PM 19122702 ER PT J AU Snyder, EG Munson, CA Gottfried, JL De Lucia, FC Gullett, B Miziolek, A AF Snyder, Emily Gibb Munson, Chase A. Gottfried, Jennifer L. De Lucia, Frank C., Jr. Gullett, Brian Miziolek, Andrzej TI Laser-induced breakdown spectroscopy for the classification of unknown powders SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT 1st North American Symposium, on Laser Induced Breakdown Spectroscopy CY OCT 08-10, 2007 CL New Orleans, LA SP Mississippi State Univ ID INDUCED FLUORESCENCE; SPORES; STATISTICS; LIBS AB Laser-induced breakdown spectroscopy (LIBS) was used to discern between two biological agent surrogates (Bacillus atrophaeus and ovalbumin) and potential interferent compounds (mold spores, humic acid, house dust, and Arizona road dust), Multiple linear regression and neural network analysis models were constructed by using B. atrophaeus and ovalbumin spectra, and limits of detection were calculated. Classification of the agent surrogates' LIBS spectra was attempted by using a neural network model. False negative rates of 0%, were observed for B. atrophaeus (100 colony forming units) spore spectra with the neural network model used for classification. (C) 2008 Optical Society of America C1 [Snyder, Emily Gibb] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [Munson, Chase A.; Gottfried, Jennifer L.; De Lucia, Frank C., Jr.; Miziolek, Andrzej] USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. [Gullett, Brian] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. RP Snyder, EG (reprint author), US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, E343-06,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA. EM snyder.emily@epa.gov RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012; Munson, Chase/H-1667-2012 NR 26 TC 18 Z9 19 U1 1 U2 10 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2008 VL 47 IS 31 BP G80 EP G87 DI 10.1364/AO.47.000G80 PG 8 WC Optics SC Optics GA 374AD UT WOS:000261013700012 PM 19122707 ER PT J AU Singh, JP Martin, MZ Miziolek, AW AF Singh, Jagdish P. Martin, Madhavi Z. Miziolek, Andrzej W. TI North American Symposium on Laser-Induced Breakdown Spectroscopy: introduction to the feature issue SO APPLIED OPTICS LA English DT Editorial Material AB This feature issue highlights the topics of the 2007 North American Symposium oil Laser-Induced Breakdown Spectroscopy (LIBS), which includes LIBS application to security and forensics, biomedical and environmental, liquid analysis, and fundamentals of LIBS, instrumentation and commercialization, fusion with LIBS, and new frontiers. (C) 2008 Optical Society of America C1 [Singh, Jagdish P.] Mississippi State Univ, Inst Clean Energy Technol, Starkville, MS 39759 USA. [Martin, Madhavi Z.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Miziolek, Andrzej W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Singh, JP (reprint author), Mississippi State Univ, Inst Clean Energy Technol, 205 Res Blvd, Starkville, MS 39759 USA. EM singh@icet.msstate.edu RI Martin, Madhavi/A-5268-2011 NR 0 TC 0 Z9 0 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 2008 VL 47 IS 31 BP LIBS1 EP LIBS1 DI 10.1364/AO.47.0LIBS1 PG 1 WC Optics SC Optics GA 374AD UT WOS:000261013700001 ER PT J AU Lo, E Fountain, AW Ingram, J AF Lo, Edisanter Fountain, Augustus W., III Ingram, John TI Statistical Modeling of Spatial Distortion in Hyperspectral Calibration SO APPLIED SPECTROSCOPY LA English DT Article DE Spectral calibration; Hyperspectral imaging; Statistical modeling ID INFORMATION AB This paper describes a statistically based efficient algorithm for the laboratory spectral calibration of a low-resolution terrestrial hyperspectral imaging camera operating in the visible range. Didymium oxide is used as a wavelength standard. The observed periodic spatial distortion in the wavelength abscissa of the hypercube is removed automatically through statistical modeling and the calibration of the wavelength abscissa is determined using a numerical method. The performance and cost of this algorithm in removing the spatial distortion are assessed quantitatively. C1 [Fountain, Augustus W., III] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Lo, Edisanter] Susquehanna Univ, Dept Math Sci, Selinsgrove, PA 17870 USA. [Ingram, John] US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. RP Fountain, AW (reprint author), Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM augustus.w.fountain@us.army.mil FU Anny Research Office; United States Military, Academy FX This research was sponsored by Dr. Paul Wilson, ARDEC, Picatinny Arsenal, NJ. The authors wish to graciously acknowledge additional Support by the Anny Research Office and the United States Military, Academy. Dr. Lo would like to thank the National Research Council and their support of his Senior Post Doctorate fellowship at the United States Military Academy. NR 14 TC 0 Z9 0 U1 0 U2 3 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD NOV PY 2008 VL 62 IS 11 BP 1189 EP 1199 PG 11 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 376QO UT WOS:000261198300005 PM 19007459 ER PT J AU Darling, MJ Bauer, A AF Darling, Matthew J. Bauer, Andrew TI Picture of the Month - Denouement and Discussion - Osteoma Cutis Associated With Pseudohypoparathyroidism Type 1a SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Editorial Material ID PROGRESSIVE OSSEOUS HETEROPLASIA; FIBRODYSPLASIA OSSIFICANS PROGRESSIVA; HETEROTOPIC OSSIFICATION; HEREDITARY OSTEODYSTROPHY; GNAS1 GENE C1 [Darling, Matthew J.; Bauer, Andrew] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Bauer, Andrew] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. RP Bauer, A (reprint author), Walter Reed Army Med Ctr, Dept Pediat, 6900 Georgia Ave, Washington, DC 20307 USA. EM abauer@usuhs.mil NR 12 TC 1 Z9 1 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD NOV PY 2008 VL 162 IS 11 BP 1091 EP 1092 DI 10.1001/archpedi.162.11.1091 PG 2 WC Pediatrics SC Pediatrics GA 368DD UT WOS:000260600600014 PM 18981359 ER PT J AU Brose, SW Boninger, ML Fullerton, B McCann, T Collinger, JL Impink, BG Dyson-Hudson, TA AF Brose, Steven W. Boninger, Michael L. Fullerton, Bradley McCann, Thane Collinger, Jennifer L. Impink, Bradley G. Dyson-Hudson, Trevor A. TI Shoulder Ultrasound Abnormalities, Physical Examination Findings, and Pain in Manual Wheelchair Users With Spinal Cord Injury SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Rehabilitation; Shoulder; Spinal cord injuries; Ultrasonography; Wheelchairs ID ROTATOR CUFF TEARS; IMPINGEMENT SYNDROME; SUBACROMIAL BURSA; UPPER EXTREMITY; LABRAL TEARS; TENDON TEARS; INDEX WUSPI; DIAGNOSIS; ULTRASONOGRAPHY; INDIVIDUALS AB Objectives: To investigate the presence of ultrasound (US) abnormalities in manual wheelchair users with spinal cord injury (SCI) using a quantitative Ultrasound Shoulder Pathology Rating Scale (USPRS). To investigate physical examination (PE) findings using a quantitative Physical Examination of the Shoulder Scale (PESS), and to obtain data about pain and other subject characteristics such as age, years with SCI, and weight. Design: Case series. Setting: National Veterans' Wheelchair Games 2005 and 2006. Participants: Volunteer sample of manual wheelchair users with SCI participating in the National Veterans' Wheelchair Games. Interventions: Not applicable. Main Outcome Measures: Presence of relationships between US findings, PE findings, pain, and subject characteristics. Results: The USPRS correlated with age, duration of SCI, and weight (all P <.01), and showed a positive trend with the total Wheelchair User's Shoulder Pain Index (WUSPI) score (r=.258, P=.073). Several US findings related to presence of PE findings for specific structures. The PESS score correlated with the WUSPI (r=.679, P <.001) and duration of SCI (P <.05). The presence of untreated shoulder pain that curtailed activity was noted in 24.5% of subjects, and this was related to increased WUSPI scores (P=.002). Conclusions: PE and US abnormalities are common in manual wheelchair users with SCL The USPRS and PESS demonstrated evidence for external validity and hold promise as research tools. Untreated shoulder pain is common in manual wheelchair users with SCI, and further investigation of this pain is indicated. C1 [Brose, Steven W.; Boninger, Michael L.; Collinger, Jennifer L.] Univ Pittsburgh, Med Ctr, Dept Phys Med & Rehabil, Pittsburgh, PA 15213 USA. [Boninger, Michael L.; Collinger, Jennifer L.; Impink, Bradley G.] Vet Affairs Pittsburgh Healthcare Syst, Human Engn Res Labs, Pittsburgh, PA USA. [Fullerton, Bradley] Patient Phys Partnership, Austin, TX USA. [Fullerton, Bradley] Childrens Hosp Austin, Austin, TX USA. [McCann, Thane] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [McCann, Thane] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Dyson-Hudson, Trevor A.] Kessler Med Rehabil Res & Educ Ctr, W Orange, NJ USA. [Dyson-Hudson, Trevor A.] Univ Med & Dent New Jersey, Dept Phys Med & Rehabil, Sch Med, Newark, NJ 07103 USA. RP Brose, SW (reprint author), Univ Pittsburgh, Med Ctr, Dept Phys Med & Rehabil, 3471 5th Ave,Ste 201, Pittsburgh, PA 15213 USA. EM brosesw@upmc.edu OI Boninger, Michael/0000-0001-6966-919X FU Veterans Affairs Center of Excellence for Wheelchairs; Associated Rehabilitation [B3142C]; National Science Foundation [DGE0333420]; National Institute on Disability and Rehabilitation [H133N000019]; Paralyzed Veterans of America FX Supported by the Veterans Affairs Center of Excellence for Wheelchairs and Associated Rehabilitation (grant no. B3142C), the National Science Foundation (grant no. DGE0333420), the National Institute on Disability and Rehabilitation (grant no. H133N000019), and the Paralyzed Veterans of America. NR 44 TC 28 Z9 29 U1 1 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD NOV PY 2008 VL 89 IS 11 BP 2086 EP 2093 DI 10.1016/j.apmr.2008.05.015 PG 8 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 373PY UT WOS:000260985600006 PM 18996236 ER PT J AU Pirooznia, M Habib, T Perkins, EJ Deng, Y AF Pirooznia, Mehdi Habib, Tanwir Perkins, Edward J. Deng, Youping TI GOfetcher: a database with complex searching facility for gene ontology SO BIOINFORMATICS LA English DT Article ID ANNOTATION; TOOL AB Motivation: An important contribution to the Gene Ontology (GO) project is to develop tools that facilitate the creation, maintenance and use of ontologies. Several tools have been created for communicating and using the GO project. However, a limitation with most of these tools is that they suffer from lack of a comprehensive search facility. We developed a web application, GOfetcher, with a very comprehensive search facility for the GO project and a variety of output formats for the results. GOfetcher has three different levels for searching the GO: Quick Search, Advanced Search and Upload Files for searching. The application includes a unique search option which generates gene information given a nucleotide or protein accession number which can then be used in generating GO information. The output data in GOfetcher can be saved into several different formats; including spreadsheet, comma-separated values and the extensible markup language (XML) format. The database is available at http://mcbc.usm.edu/gofetcher/. C1 [Pirooznia, Mehdi; Habib, Tanwir; Deng, Youping] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. [Perkins, Edward J.] USA, Ctr Res Dev & Engn, Environm Lab, Vicksburg, MS 39180 USA. RP Pirooznia, M (reprint author), Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. OI Pirooznia, Mehdi/0000-0002-4210-6458 FU Mississippi Functional Genomics Networks and Mississippi Computational Biology Consortium (NSF) [EPS-0556308]; US Army Environmental Quality Program [W912HZ-05-P-0145] FX Funding: Mississippi Functional Genomics Networks and Mississippi Computational Biology Consortium (NSF Grant # EPS-0556308); US Army Environmental Quality Program (contract # W912HZ-05-P-0145). NR 8 TC 8 Z9 8 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1367-4803 J9 BIOINFORMATICS JI Bioinformatics PD NOV 1 PY 2008 VL 24 IS 21 BP 2561 EP 2563 DI 10.1093/bioinformatics/btn441 PG 3 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Statistics & Probability SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Computer Science; Mathematical & Computational Biology; Mathematics GA 365BP UT WOS:000260381200028 PM 18728045 ER PT J AU Wu, HX Bynum, JA Stavchansky, S Bowman, PD AF Wu, Haoxiang Bynum, James A. Stavchansky, Salomon Bowman, Phillip D. TI Reuse of cDNA microarrays hybridized with cRNA by stripping with RNase H SO BIOTECHNIQUES LA English DT Article ID REPRODUCIBILITY AB DNA microarrays are powerful tools for global analysis of gene transcript expression. However their high cost and the need for replication have limited their use. Here, we report a new stripping technique applicable to microarrays hybridized with cRNA with RNase H that is reproducible, leaving the DNA oligonucleotide probes intact and available for adding two additional uses. A Pearson correlation was used to assess the agreement between the first-round hybridization and the second- and third-round hybridizations. Significant cord relations (R(2), 0.9893 and 0.975: P < 0.001) were observed among virgin arrays and stripped arrays hybridized with the same sample. Additionally, statistical class comparison analysis globally indicated that there were essentially no differences detected following three hybridizations. Dye-swapped microarrays produced similar results. However arrays stripped with RNase H exhibited decreased efficiency, of hybridization signal with increasing use. In the present study, the oligonucleotide microarrays can be used three times. C1 [Wu, Haoxiang; Bynum, James A.; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX USA. [Wu, Haoxiang; Stavchansky, Salomon] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA. RP Bowman, PD (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM phillip.bowman@amedd.army.mil FU U.S. Army Medical Research and Material Command FX The U.S. Army Medical Research and Material Command is gratefully acknowledged for funding this research. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 7 TC 3 Z9 3 U1 0 U2 0 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 0736-6205 J9 BIOTECHNIQUES JI Biotechniques PD NOV PY 2008 VL 45 IS 5 BP 573 EP 575 DI 10.2144/000112952 PG 3 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 411GL UT WOS:000263637200008 PM 19007341 ER PT J AU Figueroa, JD Sakoda, LC Graubard, BI Chanock, S Rubertone, MV Erickson, RL McGlynn, KA AF Figueroa, Jonine D. Sakoda, Lori C. Graubard, Barry I. Chanock, Stephen Rubertone, Mark V. Erickson, R. Loren McGlynn, Katherine A. TI Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors SO CANCER CAUSES & CONTROL LA English DT Article DE testicular cancer; hormone metabolism; genetic polymorphisms ID BREAST-CANCER RISK; POLYCHLORINATED-BIPHENYLS; ANDROGEN RECEPTOR; CYP1A1 POLYMORPHISMS; CYTOCHROME-P450 1A1; HSD17B1 GENE; IN-UTERO; ESTROGEN; WOMEN; EXPOSURE AB Testicular germ cell tumors (TGCT) that arise in young men are composed of two histologic types, seminomas and nonseminomas. Risk patterns for the two types appear to be similar and may be related to either endogenous or exogenous hormonal exposures in utero. Why similar risk patterns would result in different histologic types is unclear, but could be related to varying genetic susceptibility profiles. Genetic variation in hormone metabolizing genes could potentially modify hormonal exposures, and thereby affect which histologic type a man develops. To examine this hypothesis, 33 single nucleotide polymorphisms (SNPs) in four hormone metabolism candidate genes (CYP1A1, CYP17A1, HSD17B1, HSD17B4) and the androgen receptor gene (AR) were genotyped. Associations with TGCT were evaluated among 577 TGCT cases (254 seminoma, 323 nonseminoma) and 707 controls from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) study. There were no significant associations with TGCT overall based on a test using an additive model. However, compared to homozygotes of the most common allele, two nonredundant SNPs in CYP1A1 were inversely associated with nonseminoma: CYP1A1 promoter SNP rs4886605 OR = 0.75 (95% CI = 0.54-1.04) among the heterozygotes and OR = 0.37, 95% CI = 0.12-1.11 among the homozygotes with a p-value for trend = 0.02; rs2606345 intron 1 SNP, OR = 0.69 (95% CI = 0.51-0.93) among heterozygotes and OR = 0.70 (95% CI = 0.42-1.17) among homozygotes, with a p-value for trend = 0.02. Caution in interpretation is warranted until findings are replicated in other studies; however, the results suggest that genetic variation in CYP1A1 may be associated with nonseminoma. C1 [Figueroa, Jonine D.; Graubard, Barry I.; Chanock, Stephen; McGlynn, Katherine A.] NCI, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Figueroa, Jonine D.] NCI, Canc Prevent Fellowship Program, Off Prevent Oncol, NIH, Bethesda, MD 20892 USA. [Sakoda, Lori C.] Univ Washington, Dept Epidemiol, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA. [Chanock, Stephen] NCI, Dept Hlth & Human Serv, Core Genotyping Facil, Adv Technol Ctr, Bethesda, MD 20892 USA. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD USA. [Erickson, R. Loren] Walter Reed Army Inst Res, Global Emerging Infect Syst, Silver Spring, MD USA. RP Figueroa, JD (reprint author), NCI, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. EM figueroaj@mail.nih.gov FU NCI Cancer Prevention Fellowship program FX The authors wish to thank Emily Steplowski of IMS for her contributions to data management and Sabah Quraishi for her contributions to data analysis. In addition, Jonine Figueroa would like to thank Victoria Chia and Michael Cook for discussions about data presentation and the NCI Cancer Prevention Fellowship program for their support. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 60 TC 20 Z9 23 U1 1 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD NOV PY 2008 VL 19 IS 9 BP 917 EP 929 DI 10.1007/s10552-008-9153-6 PG 13 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 351WR UT WOS:000259457100003 PM 18415690 ER PT J AU Collen, J Greenburg, D Holley, A King, CS Hnatiuk, O AF Collen, Jacob Greenburg, David Holley, Aaron King, Christopher S. Hnatiuk, Oleh TI Discordance in Spirometric Interpretations Using Three Commonly Used Reference Equations vs National Health and Nutrition Examination Study III SO CHEST LA English DT Article DE airways; pulmonary function test; spirometry ID FLOW-VOLUME CURVE; PULMONARY-FUNCTION; UNITED-STATES; LUNG; OBSTRUCTION; MANAGEMENT; STANDARDS; VALUES; ADULTS; AGE AB Background: Spirometry plays an essential role in the diagnosis and management of pulmonary diseases. The accurate interpretation of spirometric data depends on comparison to a reference population to identify abnormalities in ventilatory function. National guidelines recommended the use of the National Health and Nutrition Examination Study (NHANES) III data set as the preferred reference population for those persons 8 to 80 years of age in the United States. Objectives: To determine the effect of using NHANES III reference equations, compared to those of Crapo et al (Crapo), Knudson et al (Knudson), or Morris et al (Morris), on spirometric interpretations in non-Hispanic white patients. Methods: We conducted a cross-sectional study of all white patients undergoing spirometry testing at our hospital from January 2000 through May 2007. Patients were classified as normal, restricted, obstructed, or mixed, based on the American Thoracic Society (ATS)/European Respiratory Society (ERS) guidelines, using the Crapo, Knudson, Morris, and NHANES III prediction equations. Differences in the classifications based on the reference data set were evaluated. Results: At total of 8,733 subjects (62.4% male subjects) were identified, with a mean age of 53 years. Discordance was most common when the results from prediction equations by Knudson and Mortis were compared to those of NHANES 111 (45.5% and 35.3%, respectively). Diagnostic recategorizations occurred less frequently when the prediction equations by Crapo were compared with those of NHANES 111 (15.9%). Relative to NHANES 111, the prediction equations by Knudson, Crapo, and Morris tend to overclassify obstruction and underclassify restriction. Conclusions: There is significant discordance between the prediction equations put forth by Crapo, Knudson, Morris, and the NHANES III. Our data suggest that the diagnostic reclassification of many patients undergoing pulmonary function testing will occur when ATS/ERS guidelines are implemented. Pulmonologists and other physicians interpreting spirometry need to be aware of the presence and nature of these changes. (CHEST 2008; 134:1009-1016) C1 [Collen, Jacob; Greenburg, David] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20350 USA. [Holley, Aaron; King, Christopher S.; Hnatiuk, Oleh] Walter Reed Army Med Ctr, Dept Pulm Crit Care Med, Washington, DC 20350 USA. RP King, CS (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20350 USA. EM christopher.king@na.amedd.army.mil RI Osborne, Nicholas/N-4915-2015 OI Osborne, Nicholas/0000-0002-6700-2284 NR 21 TC 25 Z9 25 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 2008 VL 134 IS 5 BP 1009 EP 1016 DI 10.1378/chest.08-0614 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 372RF UT WOS:000260918500020 PM 18988777 ER PT J AU Welch, CR Marcuson, WF Adiguzel, I AF Welch, Charles R. Marcuson, William F., III Adiguzel, Ilker TI Will Supermolecules and Supercomputers Lead to Super Construction Materials? SO CIVIL ENGINEERING LA English DT Article C1 [Welch, Charles R.] USA, ERDC, Shock & Vibrat Informat Anal Ctr, Washington, DC USA. RP Welch, CR (reprint author), USA, ERDC, Shock & Vibrat Informat Anal Ctr, Washington, DC USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD NOV PY 2008 VL 78 IS 11 BP 42 EP 52 PG 11 WC Engineering, Civil SC Engineering GA 369NS UT WOS:000260701800015 ER EF